Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FANCE	2178	broad.mit.edu	37	6	35423757	35423757	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:35423757A>G	ENST00000229769.2	+	2	667	c.482A>G	c.(481-483)cAg>cGg	p.Q161R		NM_021922.2	NP_068741.1	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	161	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)|skin(2)	13						GAAAGATGCCAGAGACAGCTC	0.612000			"""N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				17	13					0	0	0.219247	0	0
ACTC1	70	broad.mit.edu	37	15	35082644	35082644	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:35082644C>T	ENST00000290378.4	-	7	1758	c.1103G>A	c.(1102-1104)gGc>gAc	p.G368D	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	368					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AATGGATGGGCCTGCCTCATC	0.507000													103	9					0	0	0.323286	0	0
HLA-B	3106	broad.mit.edu	37	6	31324088	31324088	+	Missense_Mutation	SNP	C	C	A	rs41540612		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31324088C>A	ENST00000412585.2	-	3	503	c.475G>T	c.(475-477)Gcc>Tcc	p.A159S		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						GTGTCCGCGGCGGTCCAGGAG	0.706000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				8	55					2.17888e-05	2.30937e-05	0.058154	1	0
SPTBN2	6712	broad.mit.edu	37	11	66468181	66468181	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66468181T>G	ENST00000533211.1	-	17	3720	c.3389A>C	c.(3388-3390)gAg>gCg	p.E1130A	SPTBN2_ENST00000309996.2_Missense_Mutation_p.E1130A|SPTBN2_ENST00000529997.1_Missense_Mutation_p.E1130A			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1130					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CCGGGTCACCTCCTCGCCCAG	0.697000													12	7					0	0	0.119110	0	0
CNOT4	4850	broad.mit.edu	37	7	135047791	135047791	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:135047791T>C	ENST00000541284.1	-	12	2318	c.1988A>G	c.(1987-1989)cAg>cGg	p.Q663R	CNOT4_ENST00000423368.2_Missense_Mutation_p.Q592R|CNOT4_ENST00000473470.1_5'UTR|CNOT4_ENST00000361528.4_Missense_Mutation_p.Q589R|CNOT4_ENST00000451834.1_Missense_Mutation_p.Q660R	NM_001190849.1|NM_001190850.1	NP_001177778.1|NP_001177779.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	329					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						CAGCGGGATCTGTGTGCTGAA	0.602000													119	188					0	0	0.323286	0	0
RAG1	5896	broad.mit.edu	37	11	36597979	36597979	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:36597979A>G	ENST00000299440.5	+	2	3237	c.3125A>G	c.(3124-3126)gAa>gGa	p.E1042G		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	1042					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				GATTCAATGGAATTTTAAGTA	0.448000									Familial Hemophagocytic Lymphohistiocytosis				63	226					0	0	0.323286	0	0
HEATR5B	54497	broad.mit.edu	37	2	37280662	37280662	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:37280662C>A	ENST00000233099.5	-	17	2583	c.2488G>T	c.(2488-2490)Gtt>Ttt	p.V830F	HEATR5B_ENST00000354531.2_Missense_Mutation_p.V830F	NM_019024.1	NP_061897.1	Q9P2D3	HTR5B_HUMAN	HEAT repeat containing 5B	830							binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|pancreas(1)|prostate(1)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	77		all_hematologic(82;0.21)				GCACTAAGAACAGCAGTAAAT	0.308000													10	20					3.07112e-06	3.29908e-06	0.080935	1	0
KRTAP4-3	85290	broad.mit.edu	37	17	39324252	39324252	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39324252C>G	ENST00000391356.2	-	1	172	c.173G>C	c.(172-174)aGc>aCc	p.S58T		NM_033187.1	NP_149443.1	Q9BYR4	KRA43_HUMAN	keratin associated protein 4-3	58	29 X 5 AA repeats of C-C-[GIKRQVH]-[SPT]- [STA].					keratin filament				breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			tttgcagcagctggagataca	0.632000													16	7					0	0	0.235728	0	0
GDF15	9518	broad.mit.edu	37	19	18497006	18497006	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:18497006G>T	ENST00000595973.1	+	2	558	c.7G>T	c.(7-9)Ggg>Tgg	p.G3W	GDF15_ENST00000252809.3_Missense_Mutation_p.G3W			Q99988	GDF15_HUMAN	growth differentiation factor 15	3					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			kidney(2)|large_intestine(1)|liver(1)|lung(5)|prostate(2)|skin(1)	12						AGCCATGCCCGGGCAAGAACT	0.647000													14	30					8.04996e-18	1.04225e-17	0.234183	1	0
TAS2R60	338398	broad.mit.edu	37	7	143141421	143141421	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:143141421C>A	ENST00000332690.1	+	1	876	c.876C>A	c.(874-876)caC>caA	p.H292Q	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	292					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					CAGCAGTTCACCCCATCATTC	0.493000													251	337					3.32933e-147	6.16682e-147	0.323286	1	0
GP6	51206	broad.mit.edu	37	19	55526377	55526377	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:55526377G>T	ENST00000417454.1	-	8	959	c.932C>A	c.(931-933)cCc>cAc	p.P311H	CTC-550B14.7_ENST00000586845.1_RNA|GP6_ENST00000333884.2_Missense_Mutation_p.P293H|CTC-550B14.7_ENST00000593060.1_RNA|GP6_ENST00000310373.3_Silent_p.A312A	NM_016363.4	NP_057447.4	Q9HCN6	GPVI_HUMAN	glycoprotein VI (platelet)	311					enzyme linked receptor protein signaling pathway|leukocyte migration|platelet activation	integral to plasma membrane	collagen binding|transmembrane receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19			BRCA - Breast invasive adenocarcinoma(297;0.156)	GBM - Glioblastoma multiforme(193;0.0515)		GGGCGGGAGGGGCGGAAGCGG	0.652000													4	7					7.03913e-09	7.85309e-09	0.093190	1	0
MPHOSPH9	10198	broad.mit.edu	37	12	123694650	123694650	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:123694650C>A	ENST00000606320.1	-	8	1353	c.1147G>T	c.(1147-1149)Gag>Tag	p.E383*	MPHOSPH9_ENST00000302349.5_Nonsense_Mutation_p.E231*|MPHOSPH9_ENST00000541076.2_Nonsense_Mutation_p.E353*|MPHOSPH9_ENST00000392425.3_Nonsense_Mutation_p.E231*			Q99550	MPP9_HUMAN	M-phase phosphoprotein 9	231					M phase of mitotic cell cycle	centriole|Golgi membrane				NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(18)|prostate(2)|skin(1)	33	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000182)|Epithelial(86;0.00046)|BRCA - Breast invasive adenocarcinoma(302;0.169)		AACGTCTTCTCTAAAGTTTCA	0.438000													30	54					6.00712e-18	7.79391e-18	0.163468	1	0
CYP4F24P	388514	broad.mit.edu	37	19	15880824	15880824	+	RNA	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:15880824T>G	ENST00000595525.1	+	0	529				CYP4F24P_ENST00000587443.2_RNA																							TCCCCCAAATTTACTATCTCT	0.468000													14	14					0	0	0.160694	0	0
TNXB	7148	broad.mit.edu	37	6	32052312	32052312	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:32052312A>T	ENST00000375244.3	-	8	3524	c.3323T>A	c.(3322-3324)gTg>gAg	p.V1108E	TNXB_ENST00000375247.2_Missense_Mutation_p.V1108E			P22105	TENX_HUMAN	tenascin XB	1195	Fibronectin type-III 3.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GGGTCCTTCCACGGGCACCAC	0.612000													34	50					0	0	0.235728	0	0
LINC00458	100507428	broad.mit.edu	37	13	54705056	54705056	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:54705056G>T	ENST00000423442.2	-	0	254																											gatggtctagggggcttccaa	0.547000													8	4					0.000274275	0.000286389	0.307466	1	0
STON1	11037	broad.mit.edu	37	2	48808697	48808697	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:48808697A>C	ENST00000309835.3	+	1	935	c.925A>C	c.(925-927)Atg>Ctg	p.M309L	STON1_ENST00000404752.1_Missense_Mutation_p.M309L|STON1_ENST00000406226.1_Missense_Mutation_p.M309L|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.M309L|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.M309L|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.M309L|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.M309L|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.M309L					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			AATTTTGCAGATGTATTATGA	0.398000													15	71					0	0	0.189662	0	0
ZBTB26	57684	broad.mit.edu	37	9	125682054	125682054	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:125682054C>A	ENST00000373656.3	-	2	233	c.160G>T	c.(160-162)Ggt>Tgt	p.G54C	ZBTB26_ENST00000373654.1_Missense_Mutation_p.G54C	NM_020924.2	NP_065975.1	Q9HCK0	ZBT26_HUMAN	zinc finger and BTB domain containing 26	54	BTB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)	11						AAGGGGGAACCTGCAGCAAAC	0.358000													20	19					6.33239e-15	7.88874e-15	0.219247	1	0
SEC14L4	284904	broad.mit.edu	37	22	30899719	30899719	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:30899719G>C	ENST00000255858.7	-	2	158	c.75C>G	c.(73-75)gaC>gaG	p.D25E	SEC14L4_ENST00000392772.2_5'UTR|SEC14L4_ENST00000381982.3_Missense_Mutation_p.D25E|SEC14L4_ENST00000540456.1_5'UTR	NM_001161368.1|NM_174977.3	NP_001154840.1|NP_777637.1	Q9UDX3	S14L4_HUMAN	SEC14-like 4 (S. cerevisiae)	25						integral to membrane|intracellular	lipid binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|pancreas(1)|skin(1)	21					Vitamin E(DB00163)	TGGGCAGCAGGTCCTGGAGGT	0.632000													6	29					0	0	0.058154	0	0
PCNXL2	80003	broad.mit.edu	37	1	233134101	233134101	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:233134101C>T	ENST00000258229.8	-	32	5921	c.5687G>A	c.(5686-5688)gGc>gAc	p.G1896D	PCNXL2_ENST00000344698.2_Missense_Mutation_p.G548D	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1896						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				GGCATTGTTGCCACCTGTCGT	0.622000													28	80					0	0	0.193644	0	0
RERE	473	broad.mit.edu	37	1	8425950	8425950	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:8425950C>A	ENST00000337907.3	-	14	2003	c.1369G>T	c.(1369-1371)Gcc>Tcc	p.A457S	RERE_ENST00000377464.1_Missense_Mutation_p.A189S|RERE_ENST00000460659.1_5'UTR|RERE_ENST00000400907.2_Missense_Mutation_p.A457S|RERE_ENST00000400908.2_Missense_Mutation_p.A457S|RERE_ENST00000476556.1_5'UTR	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	457					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CTGAACACGGCCTGCCTGCGG	0.587000													36	31					6.33695e-27	9.16653e-27	0.257332	1	0
CST9L	128821	broad.mit.edu	37	20	23548946	23548946	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:23548946G>T	ENST00000376979.3	-	1	440	c.142C>A	c.(142-144)Cct>Act	p.P48T		NM_080610.2	NP_542177.1	Q9H4G1	CST9L_HUMAN	cystatin 9-like	48						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8	Colorectal(13;0.0431)|Lung NSC(19;0.235)					ACTGTGGCAGGGAGGTAACGA	0.517000													21	21					2.37509e-13	2.88344e-13	0.219247	1	0
WNK1	65125	broad.mit.edu	37	12	936338	936338	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:936338A>G	ENST00000537687.1	+	3	1706	c.1063A>G	c.(1063-1065)Atc>Gtc	p.I355V	WNK1_ENST00000530271.2_Missense_Mutation_p.I355V|WNK1_ENST00000447667.2_Missense_Mutation_p.I355V|WNK1_ENST00000315939.6_Missense_Mutation_p.I355V|WNK1_ENST00000535572.1_Missense_Mutation_p.I355V	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	355	Protein kinase.				intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ATGTGACAACATCTTTATCAC	0.468000													102	315					0	0	0.323286	0	0
EPB41L2	2037	broad.mit.edu	37	6	131277553	131277553	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:131277553C>T	ENST00000337057.3	-	2	254	c.73G>A	c.(73-75)Gaa>Aaa	p.E25K	EPB41L2_ENST00000529208.1_Missense_Mutation_p.E25K|EPB41L2_ENST00000445890.2_Missense_Mutation_p.E25K|EPB41L2_ENST00000527659.1_Missense_Mutation_p.E25K|EPB41L2_ENST00000392427.3_Missense_Mutation_p.E25K|EPB41L2_ENST00000530148.1_Intron|EPB41L2_ENST00000530481.1_Missense_Mutation_p.E25K|EPB41L2_ENST00000528282.1_Missense_Mutation_p.E25K|EPB41L2_ENST00000525193.1_Missense_Mutation_p.E25K|EPB41L2_ENST00000525271.1_Missense_Mutation_p.E25K|EPB41L2_ENST00000368128.2_Missense_Mutation_p.E25K|EPB41L2_ENST00000527411.1_Missense_Mutation_p.E25K	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	25					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		TTAGGTTTTTCCTTGGTTGCA	0.458000													17	212					0	0	0.204396	0	0
OR9G1	390174	broad.mit.edu	37	11	56468742	56468742	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56468742T>C	ENST00000312153.1	+	1	879	c.879T>C	c.(877-879)aaT>aaC	p.N293N		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						GCCTAAGGAATAAGGATGTGA	0.378000													21	173					0	0	0.116897	0	0
ADCY10	55811	broad.mit.edu	37	1	167825445	167825445	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:167825445C>A	ENST00000367848.1	-	17	2350	c.1853G>T	c.(1852-1854)tGt>tTt	p.C618F	ADCY10_ENST00000545172.1_Missense_Mutation_p.C557F|ADCY10_ENST00000367851.4_Missense_Mutation_p.C710F			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	710					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						GAGGTCAAGACAGATCTTGTT	0.468000													130	344					2.81813e-70	5.01019e-70	0.323286	1	0
CD200R1L	344807	broad.mit.edu	37	3	112545933	112545933	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:112545933T>G	ENST00000488794.1	-	6	1112	c.523A>C	c.(523-525)Agt>Cgt	p.S175R	CD200R1L_ENST00000398214.1_Missense_Mutation_p.S196R|CD200R1L_ENST00000448932.1_Missense_Mutation_p.S175R			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	196	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						GGGCATGTACTCTTAACCGTC	0.517000													19	125					0	0	0.189662	0	0
ZAK	51776	broad.mit.edu	37	2	174128549	174128549	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:174128549T>G	ENST00000375213.3	+	19	1706	c.1628T>G	c.(1627-1629)gTg>gGg	p.V543G	MLK7-AS1_ENST00000423106.2_RNA|MLTK_ENST00000409176.2_Missense_Mutation_p.V543G|MLK7-AS1_ENST00000422703.1_RNA	NM_016653.2	NP_057737.2																					CAGGATGAAGTGAAAGCAGTC	0.408000													15	122					0	0	0.132662	0	0
FCRL1	115350	broad.mit.edu	37	1	157771714	157771714	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157771714T>G	ENST00000358292.3	-	5	928	c.877A>C	c.(877-879)Aac>Cac	p.N293H	FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.N293H|FCRL1_ENST00000368176.3_Missense_Mutation_p.N293H	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	293						integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			CCTGTGAAGTTGAGTGTCACC	0.552000													22	200					0	0	0.294199	0	0
SATB2	23314	broad.mit.edu	37	2	200188558	200188558	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:200188558G>T	ENST00000443023.1	-	8	2798	c.1333C>A	c.(1333-1335)Ctg>Atg	p.L445M	SATB2_ENST00000428695.1_Missense_Mutation_p.L386M|SATB2_ENST00000260926.5_Missense_Mutation_p.L504M|SATB2_ENST00000417098.1_Missense_Mutation_p.L504M|SATB2_ENST00000457245.1_Missense_Mutation_p.L504M			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	504						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTGGCAAACAGGGCTTGAGAC	0.458000													24	175					0.000147802	0.000155167	0.116897	1	0
POGZ	23126	broad.mit.edu	37	1	151400443	151400443	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:151400443C>A	ENST00000271715.2	-	7	1248	c.934G>T	c.(934-936)Gaa>Taa	p.E312*	POGZ_ENST00000491586.1_Nonsense_Mutation_p.E259*|POGZ_ENST00000409503.1_Nonsense_Mutation_p.E303*|POGZ_ENST00000540984.1_Intron|POGZ_ENST00000368863.2_Nonsense_Mutation_p.E217*|POGZ_ENST00000392723.1_Nonsense_Mutation_p.E259*|POGZ_ENST00000361398.3_Nonsense_Mutation_p.E259*|POGZ_ENST00000531094.1_Nonsense_Mutation_p.E250*	NM_001194937.1|NM_015100.3	NP_001181866.1|NP_055915.2	Q7Z3K3	POGZ_HUMAN	pogo transposable element with ZNF domain	312					cell division|kinetochore assembly|mitotic sister chromatid cohesion|regulation of transcription, DNA-dependent	cytoplasm|nuclear chromatin	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(10)|kidney(3)|large_intestine(10)|liver(2)|lung(11)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	47	Lung SC(34;0.00471)|Ovarian(49;0.00672)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTGCTATTTTCGCCTGTAACA	0.532000													68	40					2.6465e-34	4.10838e-34	0.323286	1	0
BIRC5	332	broad.mit.edu	37	17	76210464	76210464	+	Nonstop_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:76210464A>G	ENST00000600484.1	-	8	1008	c.1009T>C	c.(1009-1011)Tga>Cga	p.*337R	BIRC5_ENST00000590449.1_Missense_Mutation_p.K23E|BIRC5_ENST00000374948.2_Missense_Mutation_p.K23E|BIRC5_ENST00000350051.3_Missense_Mutation_p.K23E|BIRC5_ENST00000301633.4_Missense_Mutation_p.K23E|BIRC5_ENST00000592734.1_Missense_Mutation_p.K23E																							CTCTACATTCAAGAACTGGCC	0.706000													4	18					0	0	0.248553	0	0
CNIH3	149111	broad.mit.edu	37	1	224922383	224922383	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:224922383C>A	ENST00000272133.3	+	5	1312	c.430C>A	c.(430-432)Ctc>Atc	p.L144I		NM_152495.1	NP_689708.1	Q8TBE1	CNIH3_HUMAN	cornichon family AMPA receptor auxiliary protein 3	144					intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane				large_intestine(5)|lung(4)	9	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		CTTCTATCTCCTCTCCTTCTT	0.517000													95	259					1.64877e-56	2.85424e-56	0.323286	1	0
EXOC3L4	91828	broad.mit.edu	37	14	103574772	103574772	+	Missense_Mutation	SNP	G	G	T	rs142666277	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:103574772G>T	ENST00000380069.3	+	10	1970	c.1894G>T	c.(1894-1896)Gtg>Ttg	p.V632L		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	632										cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						CATCCAGTGCGTGGCTGAGAT	0.622000													89	168					1.76565e-42	2.88257e-42	0.323286	1	0
TRBV4-2	28616	broad.mit.edu	37	7	142045611	142045611	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142045611G>T	ENST00000390392.3	+	0	250																											ACAACATCTGGGGCATAACGC	0.458000													103	302					4.58063e-37	7.25637e-37	0.323286	1	0
COL4A5	1287	broad.mit.edu	37	X	107863584	107863584	+	Missense_Mutation	SNP	G	G	A	rs104886355		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:107863584G>A	ENST00000328300.6	+	31	2849	c.2605G>A	c.(2605-2607)Gga>Aga	p.G869R	COL4A5_ENST00000361603.2_Missense_Mutation_p.G869R	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	869	Triple-helical region.		G -> R (in APSX; juvenile type).|Missing (in APSX).		axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						AGGGATCCCCGGAGCACCTGG	0.517000									Alport syndrome with Diffuse Leiomyomatosis				34	8					0	0	0.225048	0	0
OR51B4	79339	broad.mit.edu	37	11	5322897	5322897	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:5322897C>A	ENST00000380224.1	-	1	329	c.280G>T	c.(280-282)Gcc>Tcc	p.A94S	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_033179.2	NP_149419.2	Q9Y5P0	O51B4_HUMAN	olfactory receptor, family 51, subfamily B, member 4	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGAAACAGGCAGCATGGGCA	0.512000													178	15					2.52987e-95	4.60072e-95	0.323286	1	0
TRIM48	79097	broad.mit.edu	37	11	55032609	55032609	+	Missense_Mutation	SNP	C	C	A	rs146290222	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55032609C>A	ENST00000417545.2	+	2	364	c.278C>A	c.(277-279)gCc>gAc	p.A93D		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	77						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GCTTCCCTTGCCAGAAAAGCC	0.448000													39	24					4.67007e-22	6.42238e-22	0.268233	1	0
LMOD1	25802	broad.mit.edu	37	1	201869593	201869593	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:201869593A>G	ENST00000367288.4	-	2	794	c.548T>C	c.(547-549)gTg>gCg	p.V183A		NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	183	8 X approximate tandem repeats.				muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						cttggtggccactgccctctc	0.557000													17	65					0	0	0.189662	0	0
TKTL2	84076	broad.mit.edu	37	4	164394574	164394574	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:164394574G>T	ENST00000280605.3	-	1	473	c.313C>A	c.(313-315)Cac>Aac	p.H105N		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	105						cytoplasm	metal ion binding|transketolase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				AAGTCGCTGTGAAGTTTCCTC	0.537000													12	32					6.40141e-05	6.75935e-05	0.080935	1	0
H1FNT	341567	broad.mit.edu	37	12	48723814	48723814	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:48723814A>C	ENST00000335017.1	+	1	1052	c.740A>C	c.(739-741)aAg>aCg	p.K247T		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	247					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						CAGGAGCCCAAGAAGCCCGCA	0.612000													5	16					0	0	0.278610	0	0
UMOD	7369	broad.mit.edu	37	16	20357559	20357559	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:20357559G>T	ENST00000396134.2	-	6	1293	c.1170C>A	c.(1168-1170)gtC>gtA	p.V390V	UMOD_ENST00000424589.1_Silent_p.V390V|UMOD_ENST00000396142.2_Silent_p.V357V|UMOD_ENST00000302509.4_Silent_p.V357V|UMOD_ENST00000396138.4_Silent_p.V406V|UMOD_ENST00000570689.1_Silent_p.V357V	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	357	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GGTACATGAAGACCTTGTCGA	0.592000													17	40					1.67942e-08	1.86622e-08	0.175082	1	0
GRIK2	2898	broad.mit.edu	37	6	102134198	102134198	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:102134198C>A	ENST00000369138.1	+	6	1411	c.921C>A	c.(919-921)ccC>ccA	p.P307P	GRIK2_ENST00000358361.3_Silent_p.P307P|GRIK2_ENST00000369137.3_Silent_p.P307P|GRIK2_ENST00000421544.1_Silent_p.P307P|GRIK2_ENST00000369134.4_Silent_p.P258P|GRIK2_ENST00000318991.6_Silent_p.P307P|GRIK2_ENST00000413795.1_Silent_p.P307P	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	307					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CTCCGAAACCCGATTCAGGTT	0.393000													51	142					2.17126e-26	3.12908e-26	0.323286	1	0
CCNB3	85417	broad.mit.edu	37	X	50056876	50056876	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:50056876T>G	ENST00000376042.1	+	8	3742	c.3444T>G	c.(3442-3444)gaT>gaG	p.D1148E	CCNB3_ENST00000376038.1_Intron|CCNB3_ENST00000276014.7_Missense_Mutation_p.D1148E|CCNB3_ENST00000348603.2_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	1148					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TACTTACAGATTACATGAACA	0.393000													3	88					0	0	0.115264	0	0
BCAR3	8412	broad.mit.edu	37	1	94140198	94140198	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:94140198C>A	ENST00000370244.1	-	4	577	c.289G>T	c.(289-291)Gac>Tac	p.D97Y	BCAR3_ENST00000260502.6_Missense_Mutation_p.D97Y|BCAR3_ENST00000370243.1_Missense_Mutation_p.D97Y	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	97					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CCGTGCCGGTCCTGCCATGGG	0.517000													24	16					1.77063e-15	2.22822e-15	0.324025	1	0
EIF4G3	8672	broad.mit.edu	37	1	21220026	21220026	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:21220026C>A	ENST00000602326.1	-	16	2670	c.2087G>T	c.(2086-2088)gGt>gTt	p.G696V	EIF4G3_ENST00000536266.1_Missense_Mutation_p.G294V|EIF4G3_ENST00000537738.1_Missense_Mutation_p.G143V|EIF4G3_ENST00000544689.1_Missense_Mutation_p.G233V|EIF4G3_ENST00000264211.8_Missense_Mutation_p.G690V|EIF4G3_ENST00000374937.3_Missense_Mutation_p.G696V|EIF4G3_ENST00000374933.3_5'UTR|EIF4G3_ENST00000374935.3_Missense_Mutation_p.G410V|EIF4G3_ENST00000400422.1_Missense_Mutation_p.G690V	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	690					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GCCTCTTCCACCAGGTGTCTG	0.488000													41	110					4.44401e-20	5.95033e-20	0.290176	1	0
FAF1	11124	broad.mit.edu	37	1	50941260	50941260	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:50941260C>A	ENST00000396153.2	-	18	2196	c.1745G>T	c.(1744-1746)aGt>aTt	p.S582I	FAF1_ENST00000545823.1_Missense_Mutation_p.S340I|FAF1_ENST00000371778.4_Missense_Mutation_p.S582I	NM_007051.2	NP_008982.1	Q9UNN5	FAF1_HUMAN	Fas (TNFRSF6) associated factor 1	582	UBX.				apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			breast(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		GAACTCGCCACTGGGGGTCCG	0.532000													128	80					2.31934e-59	4.05132e-59	0.323286	1	0
CATSPERB	79820	broad.mit.edu	37	14	92139240	92139240	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:92139240C>A	ENST00000256343.3	-	13	1255	c.1099G>T	c.(1099-1101)Ggt>Tgt	p.G367C		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	367					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				ACTCCAGTACCACGCTCTTGG	0.358000													208	191					1.19097e-125	2.19811e-125	0.323286	1	0
LPPR4	9890	broad.mit.edu	37	1	99762312	99762312	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:99762312A>G	ENST00000370185.3	+	3	924	c.427A>G	c.(427-429)Att>Gtt	p.I143V	LPPR4_ENST00000457765.1_Missense_Mutation_p.I143V	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		143							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AGGAGAAGGAATTCTCTACTG	0.423000													60	147					0	0	0.323286	0	0
RNF8	9025	broad.mit.edu	37	6	37336267	37336267	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:37336267A>T	ENST00000373479.4	+	3	441	c.248A>T	c.(247-249)aAt>aTt	p.N83I	RNF8_ENST00000469731.1_Missense_Mutation_p.N83I|RNF8_ENST00000479516.1_3'UTR	NM_003958.3|NM_183078.2	NP_003949.1|NP_898901.1	O76064	RNF8_HUMAN	ring finger protein 8, E3 ubiquitin protein ligase	83	FHA.				cell division|double-strand break repair|histone H2A ubiquitination|histone H2B ubiquitination|mitosis|positive regulation of DNA repair|response to ionizing radiation	midbody|nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	13						CAGAGTCTAAATGGTGTTTGG	0.423000													60	155					0	0	0.323286	0	0
WNT2	7472	broad.mit.edu	37	7	116955360	116955360	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:116955360C>A	ENST00000265441.3	-	3	652	c.353G>T	c.(352-354)gGa>gTa	p.G118V	AC002465.2_ENST00000436097.1_RNA	NM_003391.2	NP_003382.1	P09544	WNT2_HUMAN	wingless-type MMTV integration site family member 2	118					atrial cardiac muscle tissue morphogenesis|canonical Wnt receptor signaling pathway|cardiac epithelial to mesenchymal transition|cellular response to retinoic acid|cellular response to transforming growth factor beta stimulus|dorsal/ventral axis specification|iris morphogenesis|labyrinthine layer blood vessel development|lens development in camera-type eye|lung induction|mammary gland epithelium development|neuron differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of fibroblast proliferation|positive regulation of mesenchymal cell proliferation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|proteinaceous extracellular matrix	cytokine activity|frizzled binding|frizzled-2 binding|signal transducer activity			breast(2)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|ovary(3)|prostate(1)|skin(2)	31	all_epithelial(6;2.24e-06)|Lung NSC(10;0.000936)|all_lung(10;0.00109)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		AAATACAACTCCAGCTGAGGA	0.443000													25	48					1.2476e-16	1.59201e-16	0.116897	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147336298	147336298	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:147336298C>A	ENST00000361727.3	+	13	2514	c.1998C>A	c.(1996-1998)agC>agA	p.S666R		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	666	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCGTTTACAGCGCCTCCATGG	0.498000										HNSCC(39;0.1)			43	169					3.05275e-18	3.97911e-18	0.312237	1	0
RBM15	64783	broad.mit.edu	37	1	110884807	110884807	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:110884807A>C	ENST00000369784.3	+	1	3680	c.2780A>C	c.(2779-2781)gAg>gCg	p.E927A	RBM15_ENST00000487146.2_Missense_Mutation_p.E927A|RBM15_ENST00000602849.1_Missense_Mutation_p.E927A	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	927	SPOC.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		CCACCTTGTGAGTTCTCCCAG	0.532000			T	MKL1	acute megakaryocytic leukemia								24	74					0	0	0.249174	0	0
TNS1	7145	broad.mit.edu	37	2	218712332	218712332	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:218712332G>C	ENST00000171887.4	-	17	2985	c.2533C>G	c.(2533-2535)Cag>Gag	p.Q845E	TNS1_ENST00000419504.1_Missense_Mutation_p.Q845E|TNS1_ENST00000430930.1_Missense_Mutation_p.Q845E	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	845						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		AGCAGAGGCTGAGCAGTGAGG	0.622000													17	176					0	0	0.204396	0	0
FGF19	9965	broad.mit.edu	37	11	69514322	69514322	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:69514322C>A	ENST00000294312.3	-	3	1124	c.359G>T	c.(358-360)tGt>tTt	p.C120F		NM_005117.2	NP_005108.1	O95750	FGF19_HUMAN	fibroblast growth factor 19	120					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of bile acid biosynthetic process|nervous system development|positive regulation of cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of glucose import|positive regulation of JNK cascade	extracellular region	fibroblast growth factor receptor binding|growth factor activity			large_intestine(2)|lung(2)|skin(2)	6	all_cancers(3;5.53e-114)|all_epithelial(3;1.34e-121)|Breast(3;9.28e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;6.15e-15)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;3.05e-56)|all cancers(3;2.69e-50)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)			CTCGAAAGCACAGTCTTCCTC	0.572000													11	19					1.61879e-10	1.86788e-10	0.093190	1	0
PDZD2	23037	broad.mit.edu	37	5	31799691	31799691	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:31799691T>A	ENST00000438447.1	+	2	724	c.336T>A	c.(334-336)ccT>ccA	p.P112P	PDZD2_ENST00000282493.3_Silent_p.P112P			O15018	PDZD2_HUMAN	PDZ domain containing 2	112	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						ACCAGGGTCCTGTGCTGGATG	0.572000													75	80					0	0	0.323286	0	0
PCLO	27445	broad.mit.edu	37	7	82579666	82579666	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:82579666C>A	ENST00000423517.2	-	6	10575	c.10238G>T	c.(10237-10239)aGa>aTa	p.R3413I	PCLO_ENST00000333891.8_Missense_Mutation_p.R3413I|PCLO_ENST00000437081.1_Missense_Mutation_p.R133I	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3344					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCCAGAACTTCTCTTTTTGGG	0.418000													80	142					5.86298e-51	9.9385e-51	0.323286	1	0
FAT1	2195	broad.mit.edu	37	4	187522509	187522509	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:187522509C>A	ENST00000441802.2	-	21	11763	c.11554G>T	c.(11554-11556)Gag>Tag	p.E3852*		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3852	Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						AGTTTCATCTCTAATTTGTTT	0.423000										HNSCC(5;0.00058)			28	22					1.30897e-18	1.71629e-18	0.144211	1	0
AHCTF1	25909	broad.mit.edu	37	1	247048798	247048798	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247048798T>C	ENST00000366508.1	-	21	2898	c.2762A>G	c.(2761-2763)aAt>aGt	p.N921S	AHCTF1_ENST00000326225.3_Missense_Mutation_p.N895S|AHCTF1_ENST00000391829.2_Missense_Mutation_p.N886S|AHCTF1_ENST00000470300.1_5'UTR			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	886	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			TACTTACCTATTAAAAAGCAA	0.378000													47	43					0	0	0.323286	0	0
TRDN	10345	broad.mit.edu	37	6	123714767	123714767	+	Splice_Site	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:123714767A>G	ENST00000334268.4	-	13	1423		c.e13+1		TRDN_ENST00000398178.3_Splice_Site			Q13061	TRDN_HUMAN	triadin						muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		TTTATTGCTTACCTTGTGCTG	0.338000													11	14					0	0	0.093190	0	0
AGBL1	123624	broad.mit.edu	37	15	86697684	86697684	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:86697684C>A	ENST00000441037.2	+	3	243	c.148C>A	c.(148-150)Cta>Ata	p.L50I	AGBL1_ENST00000421325.2_Missense_Mutation_p.L50I	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	50					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						ACGGAAGGCCCTAGAATTGGA	0.448000													40	89					4.07013e-28	5.96837e-28	0.268233	1	0
CHID1	66005	broad.mit.edu	37	11	903072	903072	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:903072C>A	ENST00000449825.1	-	3	507	c.151G>T	c.(151-153)Gtc>Ttc	p.V51F	CHID1_ENST00000336845.5_Missense_Mutation_p.V76F|CHID1_ENST00000436108.2_Missense_Mutation_p.V51F|CHID1_ENST00000429789.2_Missense_Mutation_p.V51F|CHID1_ENST00000526714.1_5'UTR|CHID1_ENST00000454838.2_Missense_Mutation_p.V76F|CHID1_ENST00000323541.7_Missense_Mutation_p.V81F|CHID1_ENST00000323578.8_Missense_Mutation_p.V51F|CHID1_ENST00000528581.1_Missense_Mutation_p.V76F	NM_001142675.1	NP_001136147.1	Q9BWS9	CHID1_HUMAN	chitinase domain containing 1	51					chitin catabolic process|innate immune response	extracellular region|lysosome	cation binding|chitinase activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	13		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.48e-25)|Epithelial(43;3.75e-24)|BRCA - Breast invasive adenocarcinoma(625;4.65e-05)|Lung(200;0.0624)|LUSC - Lung squamous cell carcinoma(625;0.0735)		TCCGTCACGACCAAACCCCGG	0.527000													5	11					4.096e-09	4.59946e-09	0.217242	1	0
SBNO1	55206	broad.mit.edu	37	12	123782558	123782558	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:123782558G>A	ENST00000420886.2	-	30	4005	c.4006C>T	c.(4006-4008)Cgg>Tgg	p.R1336W	SBNO1_ENST00000602398.1_Missense_Mutation_p.R1336W|SBNO1_ENST00000602750.1_Missense_Mutation_p.R1335W|SBNO1_ENST00000267176.4_Missense_Mutation_p.R1335W	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1336							ATP binding|DNA binding|hydrolase activity	p.R1335W(1)		NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GTTCTTAGCCGCACGATCTGC	0.423000													52	79					0	0	0.323286	0	0
DDX56	54606	broad.mit.edu	37	7	44608743	44608743	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:44608743G>A	ENST00000258772.5	-	10	1385	c.1279C>T	c.(1279-1281)Cgc>Tgc	p.R427C	DDX56_ENST00000431640.1_Missense_Mutation_p.R387C|DDX56_ENST00000485367.1_5'UTR	NM_001257189.1|NM_019082.3	NP_001244118.1|NP_061955.1	Q9NY93	DDX56_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 56	427					rRNA processing	nucleolus	ATP binding|ATP-dependent RNA helicase activity|identical protein binding|RNA binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|upper_aerodigestive_tract(1)	16						CAGCGATAGCGGAAGCCCTCG	0.627000													3	44					0	0	0.184627	0	0
FOLH1	2346	broad.mit.edu	37	11	49207376	49207376	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:49207376C>G	ENST00000340334.7	-	7	994	c.626G>C	c.(625-627)gGa>gCa	p.G209A	FOLH1_ENST00000533034.1_Missense_Mutation_p.G209A|FOLH1_ENST00000256999.2_Missense_Mutation_p.G224A|FOLH1_ENST00000343844.4_Intron|FOLH1_ENST00000356696.3_Missense_Mutation_p.G224A	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	224					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GAGAATGACTCCTTTGGCCCC	0.453000													26	112					0	0	0.144211	0	0
OR10H5	284433	broad.mit.edu	37	19	15905496	15905496	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:15905496T>G	ENST00000308940.8	+	1	736	c.638T>G	c.(637-639)cTc>cGc	p.L213R		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						GGCTGTTTTCTCCTCATCCTC	0.577000													33	82					0	0	0.323286	0	0
REN	5972	broad.mit.edu	37	1	204130499	204130499	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:204130499G>T	ENST00000367195.2	-	3	337	c.294C>A	c.(292-294)acC>acA	p.T98T	REN_ENST00000272190.8_Silent_p.T98T			P00797	RENI_HUMAN	renin	98					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(4)|urinary_tract(1)	19	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	CGACTTTGAAGGTCTGGGGTG	0.577000													6	26					0.000274275	0.000286389	0.307466	1	0
HRG	3273	broad.mit.edu	37	3	186394883	186394883	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:186394883C>A	ENST00000232003.4	+	7	869	c.789C>A	c.(787-789)ttC>ttA	p.F263L		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	263					fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		GACATCCCTTCCACTGGGGTG	0.478000													136	232					1.20797e-82	2.17758e-82	0.323286	1	0
PDE6A	5145	broad.mit.edu	37	5	149324063	149324063	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:149324063G>A	ENST00000255266.5	-	1	293	c.174C>T	c.(172-174)agC>agT	p.S58S		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	58					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AGATGATTTCGCTCTCCTCCA	0.542000													27	43					0	0	0.173368	0	0
BICD1	636	broad.mit.edu	37	12	32458750	32458750	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:32458750A>T	ENST00000548411.1	+	4	880	c.699A>T	c.(697-699)gaA>gaT	p.E233D	BICD1_ENST00000281474.5_Missense_Mutation_p.E233D	NM_001003398.1	NP_001003398.1	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	233					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			AACTGGAAGAAGCCCTCGAGA	0.463000													32	24					0	0	0.173368	0	0
TMEM55B	90809	broad.mit.edu	37	14	20926799	20926799	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20926799G>A	ENST00000250489.4	-	7	1039	c.753C>T	c.(751-753)atC>atT	p.I251I	TMEM55B_ENST00000398020.4_Silent_p.I258I|TMEM55B_ENST00000554028.1_Silent_p.I84I			Q86T03	TM55B_HUMAN	transmembrane protein 55B	251						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)	11	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		CAGCCAACAGGATGACAAATG	0.522000													64	57					0	0	0.323286	0	0
MARK2	2011	broad.mit.edu	37	11	63670188	63670188	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:63670188A>T	ENST00000402010.2	+	13	1929	c.1350A>T	c.(1348-1350)acA>acT	p.T450T	MARK2_ENST00000377809.4_Silent_p.T450T|MARK2_ENST00000361128.5_Silent_p.T450T|MARK2_ENST00000315032.8_Silent_p.T450T|MARK2_ENST00000350490.7_Silent_p.T449T|MARK2_ENST00000509502.2_Silent_p.T416T|MARK2_ENST00000425897.2_Silent_p.T416T|MARK2_ENST00000408948.3_Silent_p.T416T|MARK2_ENST00000502399.3_Silent_p.T449T|MARK2_ENST00000513765.2_Silent_p.T417T|MARK2_ENST00000508192.1_Silent_p.T449T|MARK2_ENST00000413835.2_Silent_p.T450T|MARK2_ENST00000377810.3_Silent_p.T416T	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	450					cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						CCAGCAGCACAGCCAAGGTGC	0.602000													33	65					0	0	0.214465	0	0
PLA2R1	22925	broad.mit.edu	37	2	160813101	160813101	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:160813101C>T	ENST00000283243.7	-	21	3148	c.2942G>A	c.(2941-2943)tGg>tAg	p.W981*	PLA2R1_ENST00000392771.1_Nonsense_Mutation_p.W981*	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	981	C-type lectin 6.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						CCAGTTCTTCCAACTGCTTGG	0.418000													71	190					0	0	0.323286	0	0
NSUN3	63899	broad.mit.edu	37	3	93845234	93845234	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:93845234G>T	ENST00000314622.4	+	6	1134	c.923G>T	c.(922-924)gGc>gTc	p.G308V		NM_022072.3	NP_071355.1	Q9H649	NSUN3_HUMAN	NOP2/Sun domain family, member 3	308							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						GCTCCCACTGGCCAGGAATGT	0.458000													6	92					4.096e-09	4.59946e-09	0.217242	1	0
FYB	2533	broad.mit.edu	37	5	39135002	39135002	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:39135002C>A	ENST00000351578.6	-	8	1820	c.1630G>T	c.(1630-1632)Gac>Tac	p.D544Y	FYB_ENST00000515010.1_Missense_Mutation_p.D544Y|FYB_ENST00000512982.1_Missense_Mutation_p.D544Y|FYB_ENST00000540520.1_Missense_Mutation_p.D554Y|FYB_ENST00000505428.1_Missense_Mutation_p.D544Y	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	544	SH3.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TCTGGGTTGTCTGTGATGCGG	0.423000													232	218					4.47166e-102	8.17035e-102	0.323286	1	0
ACBD4	79777	broad.mit.edu	37	17	43214816	43214816	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:43214816G>T	ENST00000431281.1	+	8	966	c.497G>T	c.(496-498)aGc>aTc	p.S166I	ACBD4_ENST00000586346.1_Missense_Mutation_p.S166I|ACBD4_ENST00000592162.1_Missense_Mutation_p.S166I|ACBD4_ENST00000591859.1_Missense_Mutation_p.S166I|ACBD4_ENST00000398322.3_Missense_Mutation_p.S166I|ACBD4_ENST00000591136.1_3'UTR|ACBD4_ENST00000376955.4_Missense_Mutation_p.S166I|ACBD4_ENST00000321854.8_Missense_Mutation_p.S166I	NM_001135704.1	NP_001129176.1	Q8NC06	ACBD4_HUMAN	acyl-CoA binding domain containing 4	166				S -> G (in Ref. 2; BAC11403).			fatty-acyl-CoA binding			kidney(1)|lung(3)|ovary(1)	5						GCACCCCCAAGCCCAGGTTAG	0.617000													9	18					0.000673444	0.000698011	0.069234	1	0
COPG2	26958	broad.mit.edu	37	7	130295855	130295855	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:130295855C>G	ENST00000445977.2	-	9	795	c.706G>C	c.(706-708)Gcc>Ccc	p.A236P				Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2	236					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity			large_intestine(1)	1	Melanoma(18;0.0435)					AAGCGACTGGCAATTCGGATC	0.383000													88	153					0	0	0.323286	0	0
CST9L	128821	broad.mit.edu	37	20	23548945	23548945	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:23548945G>T	ENST00000376979.3	-	1	441	c.143C>A	c.(142-144)cCt>cAt	p.P48H		NM_080610.2	NP_542177.1	Q9H4G1	CST9L_HUMAN	cystatin 9-like	48						extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8	Colorectal(13;0.0431)|Lung NSC(19;0.235)					CACTGTGGCAGGGAGGTAACG	0.512000													22	22					5.26018e-13	6.34623e-13	0.234183	1	0
FAM114A2	10827	broad.mit.edu	37	5	153414481	153414481	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:153414481C>G	ENST00000351797.4	-	2	109	c.33G>C	c.(31-33)ctG>ctC	p.L11L	FAM114A2_ENST00000520667.1_Silent_p.L11L|FAM114A2_ENST00000520313.1_Silent_p.L11L|FAM114A2_ENST00000522858.1_Silent_p.L11L	NM_018691.2	NP_061161.2	Q9NRY5	F1142_HUMAN	family with sequence similarity 114, member A2	11							purine nucleotide binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)|urinary_tract(1)	18						CTTCAGTTAGCAGTGGAGTCT	0.398000													23	35					0	0	0.249174	0	0
COL28A1	340267	broad.mit.edu	37	7	7572451	7572451	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:7572451T>C	ENST00000399429.3	-	2	196	c.56A>G	c.(55-57)cAa>cGa	p.Q19R		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	19					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGATACTGTTTGACTCGTAAA	0.338000													166	167					0	0	0.323286	0	0
DHRS7B	25979	broad.mit.edu	37	17	21075495	21075495	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:21075495C>G	ENST00000395511.3	+	2	505	c.185C>G	c.(184-186)tCa>tGa	p.S62*	DHRS7B_ENST00000579303.1_Nonsense_Mutation_p.S47*	NM_015510.4	NP_056325.2	Q6IAN0	DRS7B_HUMAN	dehydrogenase/reductase (SDR family) member 7B	62						integral to membrane|peroxisomal membrane	binding|oxidoreductase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|pancreas(2)	7						GGCGCCACCTCAGGGCTGGGC	0.687000													9	14					0	0	0.080935	0	0
ETNPPL	64850	broad.mit.edu	37	4	109684040	109684040	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:109684040G>C	ENST00000296486.3	-	1	169	c.15C>G	c.(13-15)taC>taG	p.Y5*	ETNPPL_ENST00000512646.1_5'UTR|ETNPPL_ENST00000510706.1_5'UTR|ETNPPL_ENST00000411864.2_Nonsense_Mutation_p.Y5*	NM_001146590.1|NM_031279.3	NP_001140062.1|NP_112569.2			ethanolamine-phosphate phospho-lyase																		CCCGCTTACTGTACAGCTCGC	0.647000													35	17					0	0	0.235728	0	0
TNFRSF9	3604	broad.mit.edu	37	1	7998852	7998852	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:7998852C>T	ENST00000377507.3	-	3	303	c.137G>A	c.(136-138)aGt>aAt	p.S46N		NM_001561.5	NP_001552.2	Q07011	TNR9_HUMAN	tumor necrosis factor receptor superfamily, member 9	46					induction of apoptosis|negative regulation of cell proliferation	integral to plasma membrane	binding|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Ovarian(185;0.0634)|all_lung(157;0.151)	all_epithelial(116;9.63e-21)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.000625)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;2.93e-71)|GBM - Glioblastoma multiforme(8;3.72e-37)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;7.71e-06)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000419)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00103)|READ - Rectum adenocarcinoma(331;0.0649)		AGGACAGGGACTGCAAATCTG	0.438000													59	131					0	0	0.323286	0	0
UMOD	7369	broad.mit.edu	37	16	20362075	20362075	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:20362075C>A	ENST00000396138.4	-	2	198	c.132G>T	c.(130-132)gcG>gcT	p.A44A	UMOD_ENST00000424589.1_5'UTR|UMOD_ENST00000396142.2_5'UTR|UMOD_ENST00000302509.4_5'UTR|UMOD_ENST00000396134.2_5'UTR|UMOD_ENST00000570689.1_5'UTR			P07911	UROM_HUMAN	uromodulin	0	EGF-like 1.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						CTGCTCTTCCCGCTACTTCAG	0.517000													8	19					2.27111e-07	2.481e-07	0.093190	1	0
TNN	63923	broad.mit.edu	37	1	175048527	175048527	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:175048527C>A	ENST00000239462.4	+	3	581	c.468C>A	c.(466-468)caC>caA	p.H156Q		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	156					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCAGCTGCCACTGCGAAGAGG	0.697000													3	1					8.12818e-05	8.55061e-05	0.248553	1	0
PSG7	5676	broad.mit.edu	37	19	43433783	43433783	+	RNA	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:43433783G>C	ENST00000446844.3	-	0	609				PSG7_ENST00000406070.2_RNA			Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				CTTGCATCTGGAGTCTCAGGA	0.527000													513	194					0	0	0.323286	0	0
CSTF1	1477	broad.mit.edu	37	20	54974030	54974030	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:54974030A>G	ENST00000217109.4	+	5	1005	c.653A>G	c.(652-654)gAa>gGa	p.E218G	CSTF1_ENST00000493039.1_3'UTR	NM_001033521.1|NM_001324.2	NP_001028693.1|NP_001315.1	Q05048	CSTF1_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa	218					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	15			Colorectal(105;0.202)			CAGGAAGCTGAAATGTTACGT	0.388000													58	70					0	0	0.323286	0	0
CD1B	910	broad.mit.edu	37	1	158300659	158300659	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158300659C>T	ENST00000368168.3	-	2	362	c.255G>A	c.(253-255)gaG>gaA	p.E85E		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	85					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					GGAATATCTCCTCTAACTCAG	0.458000													659	454					0	0	0.323286	0	0
ZNF831	128611	broad.mit.edu	37	20	57766770	57766770	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:57766770C>A	ENST00000371030.2	+	1	696	c.696C>A	c.(694-696)agC>agA	p.S232R		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	232						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGGGCGAGAGCAGGTGCCAGG	0.692000													24	26					3.01185e-09	3.38573e-09	0.294199	1	0
PAPPA	5069	broad.mit.edu	37	9	119124899	119124899	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:119124899G>A	ENST00000328252.3	+	18	4745	c.4376G>A	c.(4375-4377)cGg>cAg	p.R1459Q	PAPPA_ENST00000534838.1_Missense_Mutation_p.R497Q	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1459	Sushi 4.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						ATTCATTGCCGGAAAGATGGC	0.502000													5	180					0	0	0.184627	0	0
KCNH3	23416	broad.mit.edu	37	12	49948152	49948152	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:49948152C>G	ENST00000257981.6	+	11	2211	c.1951C>G	c.(1951-1953)Cgg>Ggg	p.R651G		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	651					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						TGAGCTGCCCCGGCGGGAGCA	0.642000													12	35					0	0	0.160694	0	0
DSG4	147409	broad.mit.edu	37	18	28980940	28980940	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:28980940T>A	ENST00000359747.4	+	10	1403	c.1374T>A	c.(1372-1374)taT>taA	p.Y458*	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG4_ENST00000308128.4_Nonsense_Mutation_p.Y458*	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	458	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGTCAAAATATATTATCAATG	0.289000													6	80					0	0	0.217242	0	0
ADNP	23394	broad.mit.edu	37	20	49510781	49510781	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:49510781G>T	ENST00000396029.3	-	5	1037	c.470C>A	c.(469-471)gCt>gAt	p.A157D	ADNP_ENST00000396032.3_Missense_Mutation_p.A157D|ADNP_ENST00000371602.4_Missense_Mutation_p.A157D|ADNP_ENST00000349014.3_Missense_Mutation_p.A157D	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	157						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						TACACTGTCAGCCTGCTTAGG	0.403000													17	269					2.39187e-15	3.00269e-15	0.204396	1	0
UXT	8409	broad.mit.edu	37	X	47517012	47517012	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:47517012C>A	ENST00000335890.2	-	3	396	c.243G>T	c.(241-243)atG>atT	p.M81I	UXT_ENST00000333119.3_Missense_Mutation_p.M69I	NM_153477.2	NP_705582.1	Q9UBK9	UXT_HUMAN	ubiquitously-expressed, prefoldin-like chaperone	69					centrosome organization|mitochondrion transport along microtubule|protein folding	centrosome|nucleus|prefoldin complex	beta-tubulin binding|microtubule binding|unfolded protein binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(1)	6						AATCCACCTGCATATATAACT	0.542000													84	9					2.16136e-38	3.45393e-38	0.323286	1	0
SIGLEC12	89858	broad.mit.edu	37	19	52002708	52002708	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:52002708G>T	ENST00000291707.3	-	3	1126	c.1071C>A	c.(1069-1071)gtC>gtA	p.V357V	SIGLEC12_ENST00000598614.1_Silent_p.V239V	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	357	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TGTTGAGTCGGACAGCCCTGG	0.607000													50	39					8.81991e-31	1.32792e-30	0.323286	1	0
HEATR6	63897	broad.mit.edu	37	17	58150535	58150535	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:58150535A>C	ENST00000184956.6	-	4	590	c.574T>G	c.(574-576)Tta>Gta	p.L192V	HEATR6_ENST00000585976.1_Missense_Mutation_p.L192V	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	192							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			CTGAGACATAAGTTTGCCATA	0.483000													10	117					0	0	0.058154	0	0
OR2M3	127062	broad.mit.edu	37	1	248367108	248367108	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248367108G>T	ENST00000456743.1	+	1	777	c.739G>T	c.(739-741)Gtg>Ttg	p.V247L		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCACCTCTTGGTGGTGGGAAT	0.483000													343	167					2.99587e-157	5.5558e-157	0.323286	1	0
SPTBN1	6711	broad.mit.edu	37	2	54855368	54855368	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:54855368G>T	ENST00000333896.5	+	12	2125	c.1740G>T	c.(1738-1740)aaG>aaT	p.K580N	SPTBN1_ENST00000356805.4_Missense_Mutation_p.K593N	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	593					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			CCGCCCAGAAGTTCGCAACAG	0.512000													17	33					7.45023e-12	8.82346e-12	0.219247	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84657463	84657463	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:84657463G>T	ENST00000286744.5	+	22	3961	c.3737G>T	c.(3736-3738)gGg>gTg	p.G1246V	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.G1246V	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1246	Ig-like C2-type 2.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GATGGAACTGGGAAGATACAG	0.378000													35	69					1.59361e-14	1.97495e-14	0.246493	1	0
SVEP1	79987	broad.mit.edu	37	9	113168921	113168921	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:113168921T>G	ENST00000401783.2	-	38	9295	c.8959A>C	c.(8959-8961)Aga>Cga	p.R2987R	SVEP1_ENST00000374469.1_Silent_p.R2964R|SVEP1_ENST00000297826.5_Silent_p.R913R	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2987	Sushi 26.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AGGCACCTTCTTGATGAATTT	0.468000													30	28					0	0	0.144211	0	0
BAI1	575	broad.mit.edu	37	8	143561119	143561119	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:143561119G>T	ENST00000517894.1	+	9	2686	c.1792G>T	c.(1792-1794)Gag>Tag	p.E598*	BAI1_ENST00000323289.5_Nonsense_Mutation_p.E598*			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	598					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCCAGCGGGAGAGGTGGCTGC	0.647000													14	24					6.49762e-13	7.81784e-13	0.175082	1	0
GPR52	9293	broad.mit.edu	37	1	174417408	174417408	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:174417408G>C	ENST00000367685.2	+	1	197	c.159G>C	c.(157-159)ctG>ctC	p.L53L	RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000251507.4_Intron|RABGAP1L_ENST00000357444.6_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	53						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						TGACATTTCTGATCATTGCTG	0.443000													47	104					0	0	0.312237	0	0
C1QB	713	broad.mit.edu	37	1	22986051	22986051	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:22986051C>A	ENST00000509305.1	+	2	442	c.96C>A	c.(94-96)ccC>ccA	p.P32P	C1QB_ENST00000314933.6_Silent_p.P34P			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	34					complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCACCGGGCCCCCAGCCATCC	0.597000													65	135					2.09306e-48	3.50012e-48	0.323286	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5186188	5186188	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:5186188G>T	ENST00000274181.7	+	5	925	c.787G>T	c.(787-789)Gac>Tac	p.D263Y	ADAMTS16_ENST00000511368.1_Missense_Mutation_p.D263Y	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	263					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						TCCCAAGGAAGACCTCTTCAT	0.488000													133	156					5.48206e-51	9.29788e-51	0.323286	1	0
CAPRIN2	65981	broad.mit.edu	37	12	30863016	30863016	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:30863016T>A	ENST00000251071.5	-	18	3954	c.3204A>T	c.(3202-3204)gaA>gaT	p.E1068D	CAPRIN2_ENST00000308433.5_Missense_Mutation_p.E734D|CAPRIN2_ENST00000298892.5_Missense_Mutation_p.E1018D|CAPRIN2_ENST00000395805.2_3'UTR	NM_001002259.1|NM_032156.3	NP_001002259.1|NP_115532.3	Q6IMN6	CAPR2_HUMAN	caprin family member 2	1068	C1q.				negative regulation of cell growth|negative regulation of translation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of dendrite morphogenesis|positive regulation of dendritic spine morphogenesis|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of transcription from RNA polymerase II promoter	mitochondrion|receptor complex	receptor binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(4)|large_intestine(13)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	48	all_lung(12;1.13e-09)|Lung NSC(12;7.98e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					CCAAGACCTCTTCATTCTTCA	0.438000													63	6					0	0	0.323286	0	0
FBXO8	26269	broad.mit.edu	37	4	175180957	175180957	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:175180957C>A	ENST00000393674.2	-	3	1211	c.349G>T	c.(349-351)Ggt>Tgt	p.G117C	FBXO8_ENST00000503293.1_Missense_Mutation_p.G76C	NM_012180.2	NP_036312.2	Q9NRD0	FBX8_HUMAN	F-box protein 8	117					regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|urinary_tract(1)	14		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		GAACAGTGACCCCAAGTGGAT	0.343000													63	17					2.18329e-32	3.34404e-32	0.323286	1	0
CSRP2BP	57325	broad.mit.edu	37	20	18143407	18143407	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:18143407G>T	ENST00000278816.2	+	7	2139	c.1489G>T	c.(1489-1491)Gtc>Ttc	p.V497F	CSRP2BP_ENST00000435364.2_Missense_Mutation_p.V497F|CSRP2BP_ENST00000377681.2_Missense_Mutation_p.V496F|CSRP2BP_ENST00000489634.2_Missense_Mutation_p.V369F			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	497					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						CAAACTGATTGTCAGACAAGC	0.478000													109	7					2.91707e-64	5.14475e-64	0.323286	1	0
FAM205A	259308	broad.mit.edu	37	9	34729283	34729283	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:34729283G>A	ENST00000378788.3	-	1	181	c.142C>T	c.(142-144)Cgg>Tgg	p.R48W		NM_001141917.1	NP_001135389.1	Q6ZU69	CI14B_HUMAN	family with sequence similarity 205, member A	48						integral to membrane				breast(1)|endometrium(2)|kidney(1)	4						AGCCCTACCCGGCAGCAGCTC	0.423000													9	33					0	0	0.307466	0	0
PCDH8	5100	broad.mit.edu	37	13	53422150	53422150	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:53422150G>T	ENST00000377942.3	-	1	625	c.422C>A	c.(421-423)cCg>cAg	p.P141Q	PCDH8_ENST00000338862.4_Missense_Mutation_p.P141Q	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	141	Cadherin 2.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CACCTCTACCGGGATCTGGGC	0.697000													7	14					2.17888e-05	2.30937e-05	0.058154	1	0
UBE3A	7337	broad.mit.edu	37	15	25601071	25601071	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:25601071C>T	ENST00000232165.3	-	9	2748	c.2092G>A	c.(2092-2094)Gat>Aat	p.D698N	UBE3A_ENST00000428984.2_Missense_Mutation_p.D678N|UBE3A_ENST00000438097.1_Missense_Mutation_p.D678N|UBE3A_ENST00000566215.1_Missense_Mutation_p.D678N|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000397954.2_Missense_Mutation_p.D701N	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	701					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GGAATTTTATCACCATTTTCC	0.313000													22	37					0	0	0.264190	0	0
CD163L1	283316	broad.mit.edu	37	12	7531839	7531839	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:7531839T>G	ENST00000313599.3	-	9	2163	c.2106A>C	c.(2104-2106)aaA>aaC	p.K702N	CD163L1_ENST00000544331.1_5'UTR|CD163L1_ENST00000396630.1_Missense_Mutation_p.K702N|CD163L1_ENST00000416109.2_Missense_Mutation_p.K712N			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	702	SRCR 7.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						TCACCTCAACTTTTCCAGCAC	0.478000													7	51					0	0	0.307466	0	0
CLDN17	26285	broad.mit.edu	37	21	31538616	31538616	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:31538616C>A	ENST00000286808.3	-	1	355	c.320G>T	c.(319-321)tGc>tTc	p.C107F		NM_012131.2	NP_036263.1	P56750	CLD17_HUMAN	claudin 17	107					calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(2)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	23						AGAGCCTGTGCACTGGACCTG	0.572000													80	110					3.76144e-29	5.56844e-29	0.323286	1	0
MYO18B	84700	broad.mit.edu	37	22	26306919	26306919	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:26306919C>A	ENST00000335473.7	+	33	5516	c.5266C>A	c.(5266-5268)Cag>Aag	p.Q1756K	MYO18B_ENST00000536101.1_Missense_Mutation_p.Q1756K|MYO18B_ENST00000407587.2_Missense_Mutation_p.Q1757K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1756	Gln-rich.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						ACAGCTTCATCAGCTGGAAAT	0.493000													54	6					2.02796e-37	3.22081e-37	0.323286	1	0
MON1B	22879	broad.mit.edu	37	16	77232114	77232114	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:77232114G>C	ENST00000248248.3	+	6	1903	c.1553G>C	c.(1552-1554)cGg>cCg	p.R518P	MON1B_ENST00000545553.1_Missense_Mutation_p.R372P|MON1B_ENST00000439557.2_Missense_Mutation_p.R409P	NM_014940.2	NP_055755.1	Q7L1V2	MON1B_HUMAN	MON1 secretory trafficking family member B	518							protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	17						GAGGAGGACCGGCTCTTCATT	0.537000													162	361					0	0	0.323286	0	0
SCN11A	11280	broad.mit.edu	37	3	38889099	38889099	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:38889099A>T	ENST00000450244.1	-	26	4660	c.4462T>A	c.(4462-4464)Ttt>Att	p.F1488I	SCN11A_ENST00000456224.3_Missense_Mutation_p.F1450I|SCN11A_ENST00000302328.3_Missense_Mutation_p.F1488I			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1488					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATCAGAGCAAAGAGGAGAGTC	0.483000													24	37					0	0	0.279207	0	0
MGAM	8972	broad.mit.edu	37	7	141730529	141730529	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:141730529C>G	ENST00000475668.2	+	12	1496	c.1442C>G	c.(1441-1443)tCa>tGa	p.S481*	MGAM_ENST00000549489.2_Nonsense_Mutation_p.S481*			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	481	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTGAATAGTTCAGATGGAGTG	0.478000													91	283					0	0	0.323286	0	0
HOXB13	10481	broad.mit.edu	37	17	46804345	46804345	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:46804345A>T	ENST00000290295.7	-	2	1246	c.662T>A	c.(661-663)aTt>aAt	p.I221N		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	221					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						GCTGTACGGAATGCGTTTCTT	0.627000													43	71					0	0	0.323286	0	0
RIMS1	22999	broad.mit.edu	37	6	72806843	72806843	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:72806843G>A	ENST00000264839.7	+	3	437	c.437G>A	c.(436-438)cGc>cAc	p.R146H	RIMS1_ENST00000517960.1_Missense_Mutation_p.R146H|RIMS1_ENST00000491071.2_Missense_Mutation_p.R146H|RIMS1_ENST00000522291.1_Missense_Mutation_p.R146H|RIMS1_ENST00000520567.1_Missense_Mutation_p.R146H|RIMS1_ENST00000521978.1_Missense_Mutation_p.R146H|RIMS1_ENST00000348717.5_Missense_Mutation_p.R146H|RIMS1_ENST00000518273.1_Missense_Mutation_p.R146H			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	146	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				TGCGGAGGCCGCGTGTCTCTA	0.488000													7	98					0	0	0.248553	0	0
AOX1	316	broad.mit.edu	37	2	201534460	201534460	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:201534460A>G	ENST00000374700.2	+	34	4202	c.3961A>G	c.(3961-3963)Aaa>Gaa	p.K1321E	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	1321					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CAAGTTCACAAAAATGGTACG	0.453000													27	237					0	0	0.324025	0	0
ACVR1C	130399	broad.mit.edu	37	2	158412629	158412629	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:158412629C>G	ENST00000243349.7	-	3	880	c.520G>C	c.(520-522)Gtg>Ctg	p.V174L	ACVR1C_ENST00000409680.3_Missense_Mutation_p.V124L|ACVR1C_ENST00000348328.5_Intron|ACVR1C_ENST00000335450.7_Intron	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	174	GS.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						GAGGCGGTCACATCATAAATC	0.348000													40	49					0	0	0.268233	0	0
HYAL2	8692	broad.mit.edu	37	3	50357134	50357134	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:50357134G>C	ENST00000447092.1	-	1	3079	c.787C>G	c.(787-789)Cat>Gat	p.H263D	HYAL2_ENST00000395139.3_Missense_Mutation_p.H263D|HYAL2_ENST00000357750.4_Missense_Mutation_p.H263D|HYAL2_ENST00000442581.1_Missense_Mutation_p.H263D			Q12891	HYAL2_HUMAN	hyaluronoglucosaminidase 2	263						anchored to membrane|lysosome|plasma membrane	hyalurononglucosaminidase activity|receptor activity			breast(1)|endometrium(2)|kidney(1)|ovary(1)|prostate(1)|skin(1)	7				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)	Hyaluronidase(DB00070)	TTGCGGCCATGGCGGGAGGAA	0.617000													6	8					0	0	0.278610	0	0
PKD1L1	168507	broad.mit.edu	37	7	47840434	47840434	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:47840434C>A	ENST00000289672.2	-	54	8056	c.8006G>T	c.(8005-8007)cGa>cTa	p.R2669L	C7orf69_ENST00000418326.2_Intron|C7orf69_ENST00000258776.4_Intron	NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2669					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GAGCAGAAATCGGTGCAGGTG	0.552000													24	123					1.55469e-16	1.98144e-16	0.279207	1	0
FCRL6	343413	broad.mit.edu	37	1	159779402	159779402	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:159779402G>T	ENST00000321935.6	+	6	922	c.836G>T	c.(835-837)gGg>gTg	p.G279V	FCRL6_ENST00000392235.3_Missense_Mutation_p.G177V|FCRL6_ENST00000368106.3_Missense_Mutation_p.G272V|FCRL6_ENST00000339348.5_Missense_Mutation_p.G272V			Q6DN72	FCRL6_HUMAN	Fc receptor-like 6	272	Ig-like C2-type 3.					integral to membrane				NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	24	all_hematologic(112;0.0597)					CAGGATGCTGGGAACTACTCC	0.517000													126	244					6.51928e-57	1.13047e-56	0.323286	1	0
GIMAP1	170575	broad.mit.edu	37	7	150417295	150417295	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:150417295C>T	ENST00000307194.5	+	3	343	c.203C>T	c.(202-204)aCg>aTg	p.T68M		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCCTGCACCACGGGCAGCCGC	0.627000													21	107					0	0	0.309145	0	0
MGAT5B	146664	broad.mit.edu	37	17	74944047	74944047	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:74944047C>A	ENST00000569840.2	+	17	2633	c.2059C>A	c.(2059-2061)Cac>Aac	p.H687N	MGAT5B_ENST00000301618.4_Missense_Mutation_p.H685N|MGAT5B_ENST00000428789.2_Missense_Mutation_p.H696N	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	687						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCCCCCCGCGCACGCCCTGCG	0.711000													17	4					2.27525e-19	3.01776e-19	0.294199	1	0
NCKAP5	344148	broad.mit.edu	37	2	133540444	133540444	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:133540444G>T	ENST00000409261.1	-	14	4313	c.3940C>A	c.(3940-3942)Cgg>Agg	p.R1314R	NCKAP5_ENST00000317721.6_Silent_p.R1314R|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1314							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GAGTTCTGCCGGGTAAGAGAA	0.587000													27	89					1.06647e-15	1.34591e-15	0.193644	1	0
CCDC150	284992	broad.mit.edu	37	2	197504376	197504376	+	Translation_Start_Site	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:197504376A>T	ENST00000389175.4	+	0	21				CCDC150_ENST00000272831.7_De_novo_Start_OutOfFrame	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150											breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						ATGCCCTGCCACGGGTGCGCC	0.667000													7	4					0	0	0.248553	0	0
ERV3-1	2086	broad.mit.edu	37	7	64453398	64453398	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:64453398C>A	ENST00000394323.2	-	2	507	c.7G>T	c.(7-9)Ggt>Tgt	p.G3C		NM_001007253.3	NP_001007254.2	Q14264	ENR1_HUMAN		3						virion				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(8)	16						atgttcatacccagcatggac	0.448000													15	113					2.32078e-09	2.61839e-09	0.132662	1	0
SIGLEC16	400709	broad.mit.edu	37	19	50475128	50475128	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:50475128C>A	ENST00000602139.1	+	0	1074									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						AACGGCACATCCCTCCGGGTC	0.657000													23	25					4.22769e-11	4.94642e-11	0.116897	1	0
DOCK11	139818	broad.mit.edu	37	X	117810668	117810668	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:117810668G>T	ENST00000276204.6	+	48	5502	c.5428G>T	c.(5428-5430)Gag>Tag	p.E1810*	DOCK11_ENST00000276202.7_Nonsense_Mutation_p.E1810*			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1810	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						GTTTGGTACGGAGAATGTCAA	0.368000													16	4					9.7654e-05	0.000102694	0.189662	1	0
DDX25	29118	broad.mit.edu	37	11	125780320	125780320	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:125780320T>A	ENST00000263576.6	+	7	724	c.569T>A	c.(568-570)aTg>aAg	p.M190K	DDX25_ENST00000525943.1_3'UTR|RP11-680F20.9_ENST00000533033.2_RNA	NM_013264.4	NP_037396.3	Q9UHL0	DDX25_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 25	190	Helicase ATP-binding.				mRNA export from nucleus|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|nucleus	ATP binding|ATP-dependent RNA helicase activity|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)	10	all_hematologic(175;0.177)	Breast(109;0.0021)|all_lung(97;0.0203)|Lung NSC(97;0.0203)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.14e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.046)		GTTGAGCAGATGGGAAAATTC	0.478000													75	188					0	0	0.323286	0	0
NES	10763	broad.mit.edu	37	1	156642581	156642581	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:156642581C>G	ENST00000368223.3	-	4	1531	c.1399G>C	c.(1399-1401)Gca>Cca	p.A467P		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	467	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGGGTGGTGCCAAGGAGGCA	0.627000													11	58					0	0	0.160694	0	0
C3orf56	285311	broad.mit.edu	37	3	126915964	126915964	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:126915964G>T	ENST00000398112.1	+	2	676	c.436G>T	c.(436-438)Ggc>Tgc	p.G146C		NM_001007534.2	NP_001007535.1			chromosome 3 open reading frame 56											breast(1)|endometrium(2)|kidney(1)|lung(5)	9				GBM - Glioblastoma multiforme(114;0.142)		TCCCACTCTGGGCGGGGCCAC	0.632000													17	58					7.07596e-05	7.4589e-05	0.175082	1	0
EXPH5	23086	broad.mit.edu	37	11	108381673	108381673	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:108381673C>A	ENST00000265843.4	-	6	4671	c.4561G>T	c.(4561-4563)Gag>Tag	p.E1521*	EXPH5_ENST00000443411.1_Nonsense_Mutation_p.E1333*|EXPH5_ENST00000525344.1_Nonsense_Mutation_p.E1514*|EXPH5_ENST00000428840.1_Nonsense_Mutation_p.E1445*	NM_015065.2	NP_055880.2	Q149M6	Q149M6_HUMAN	exophilin 5	1521					intracellular protein transport		Rab GTPase binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(13)|liver(1)|lung(34)|ovary(3)|pancreas(2)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(1)	91		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TGAGTCTCCTCACCAAGCTGT	0.423000													45	26					3.68337e-26	5.29592e-26	0.323286	1	0
MDGA2	161357	broad.mit.edu	37	14	47504285	47504285	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:47504285C>A	ENST00000426342.1	-	8	1600	c.854G>T	c.(853-855)aGa>aTa	p.R285I	MDGA2_ENST00000357362.3_Missense_Mutation_p.R285I|MDGA2_ENST00000439988.2_Missense_Mutation_p.R514I|MDGA2_ENST00000399232.2_Missense_Mutation_p.R583I	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	514	Ig-like 3.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						GGTCTGACATCTGTACATTCC	0.408000													85	72					1.07134e-49	1.80126e-49	0.323286	1	0
ITIH2	3698	broad.mit.edu	37	10	7745435	7745435	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:7745435T>G	ENST00000358415.4	+	1	204	c.38T>G	c.(37-39)cTt>cGt	p.L13R	ITIH2_ENST00000480387.1_3'UTR|ITIH2_ENST00000379587.4_Missense_Mutation_p.L13R	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	13					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TGCTTCTTTCTTTCTGAAGTA	0.428000													55	176					0	0	0.323286	0	0
KIAA1045	23349	broad.mit.edu	37	9	34971409	34971409	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:34971409T>A	ENST00000242315.3	+	2	196	c.114T>A	c.(112-114)ggT>ggA	p.G38G	KIAA1045_ENST00000476115.2_Intron|KIAA1045_ENST00000544237.1_Silent_p.G38G	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	38							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			GACGCACAGGTGAGCTGCCAG	0.617000													56	76					0	0	0.323286	0	0
S100A8	6279	broad.mit.edu	37	1	153362656	153362656	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:153362656G>A	ENST00000368733.3	-	3	374	c.205C>T	c.(205-207)Cag>Tag	p.Q69*	S100A8_ENST00000368732.1_Nonsense_Mutation_p.Q69*	NM_002964.4	NP_002955.2	P05109	S10A8_HUMAN	S100 calcium binding protein A8	69	EF-hand 2.				chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding			breast(1)|endometrium(1)|lung(1)|urinary_tract(1)	4	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGAACTCCTGGAAGTTAACT	0.468000													53	156					0	0	0.323286	0	0
RYR2	6262	broad.mit.edu	37	1	237831190	237831190	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:237831190C>T	ENST00000366574.2	+	58	8839	c.8522C>T	c.(8521-8523)gCa>gTa	p.A2841V	RYR2_ENST00000360064.6_Missense_Mutation_p.A2839V|RYR2_ENST00000542537.1_Missense_Mutation_p.A2825V	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2841	4 X approximate repeats.|Modulator (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAGGCTATGGCAGAAATGATG	0.259000													15	5					0	0	0.189662	0	0
RTN4RL1	146760	broad.mit.edu	37	17	1840809	1840809	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:1840809C>T	ENST00000331238.5	-	2	325	c.307G>A	c.(307-309)Gag>Aag	p.E103K		NM_178568.2	NP_848663.1	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1	103					axon regeneration	anchored to plasma membrane	receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|prostate(2)|skin(1)	11						TCCAGCTCCTCCAGGTGCACG	0.637000													11	27					0	0	0.132662	0	0
FRMD4B	23150	broad.mit.edu	37	3	69225773	69225773	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:69225773G>A	ENST00000542259.1	-	23	3175	c.2724C>T	c.(2722-2724)acC>acT	p.T908T	FRMD4B_ENST00000478263.1_Silent_p.T614T|FRMD4B_ENST00000398540.3_Silent_p.T962T			Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	962						cytoplasm|cytoskeleton	binding			NS(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(2)	19		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TGGTTAACTGGGTCCTCCAGT	0.388000													28	45					0	0	0.116897	0	0
GRIA1	2890	broad.mit.edu	37	5	153054124	153054124	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:153054124T>A	ENST00000285900.5	+	6	1107	c.764T>A	c.(763-765)cTg>cAg	p.L255Q	GRIA1_ENST00000518783.1_Missense_Mutation_p.L265Q|GRIA1_ENST00000518142.1_Missense_Mutation_p.L175Q|GRIA1_ENST00000521843.2_Missense_Mutation_p.L186Q|GRIA1_ENST00000340592.5_Missense_Mutation_p.L255Q|GRIA1_ENST00000448073.4_Missense_Mutation_p.L265Q	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	255					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	GGTTTCCAGCTGGTGAACTAC	0.512000													195	186					0	0	0.323286	0	0
ZAP70	7535	broad.mit.edu	37	2	98349367	98349367	+	Missense_Mutation	SNP	G	G	T	rs56186053		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:98349367G>T	ENST00000264972.5	+	5	800	c.585G>T	c.(583-585)caG>caT	p.Q195H	ZAP70_ENST00000442208.1_Missense_Mutation_p.Q69H|ZAP70_ENST00000463643.1_3'UTR	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	195	SH2 2.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						GGAAGGAGCAGGGCACATACG	0.632000													15	29					1.45105e-14	1.80044e-14	0.175082	1	0
FASLG	356	broad.mit.edu	37	1	172629278	172629278	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:172629278T>C	ENST00000367721.2	+	2	576	c.392T>C	c.(391-393)aTa>aCa	p.I131T	FASLG_ENST00000340030.3_Intron	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	131					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						GAGAAGCAAATAGGTGAGTCT	0.358000													43	116					0	0	0.323286	0	0
EPAS1	2034	broad.mit.edu	37	2	46607812	46607812	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:46607812G>T	ENST00000263734.3	+	12	2511	c.2001G>T	c.(1999-2001)ttG>ttT	p.L667F		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	667					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CAGCGCCGTTGGGGCCCCCTG	0.597000													68	77					2.32478e-39	3.7363e-39	0.323286	1	0
PELP1	27043	broad.mit.edu	37	17	4577819	4577819	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:4577819G>A	ENST00000301396.4	-	13	2225	c.2000C>T	c.(1999-2001)gCg>gTg	p.A667V	PELP1_ENST00000572293.1_Missense_Mutation_p.A573V|PELP1_ENST00000269230.7_Intron|PELP1_ENST00000436683.2_Missense_Mutation_p.A376V|PELP1_ENST00000574876.1_Missense_Mutation_p.A523V			Q8IZL8	PELP1_HUMAN	proline, glutamate and leucine rich protein 1	523	Pro-rich.				transcription, DNA-dependent	cytoplasm|MLL1 complex	protein binding			breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	15						GAGTGCAGCCGCACACACGTC	0.617000													4	94					0	0	0.217242	0	0
COL5A2	1290	broad.mit.edu	37	2	189914108	189914108	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:189914108C>A	ENST00000374866.3	-	44	3386	c.3112G>T	c.(3112-3114)Ggc>Tgc	p.G1038C		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	1038					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCATTGGAGCCTGGGGGCCCC	0.453000													19	22					1.10513e-12	1.32402e-12	0.249174	1	0
ITGA11	22801	broad.mit.edu	37	15	68606130	68606130	+	Missense_Mutation	SNP	C	C	A	rs141749560	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:68606130C>A	ENST00000423218.2	-	23	2964	c.2869G>T	c.(2869-2871)Gtc>Ttc	p.V957F	ITGA11_ENST00000315757.7_Missense_Mutation_p.V957F			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	957					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GTGAAGAGGACGTCAGCCTCG	0.642000													14	35					1.05317e-09	1.19563e-09	0.119110	1	0
OGG1	4968	broad.mit.edu	37	3	9792631	9792631	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:9792631G>T	ENST00000302036.7	+	2	483	c.140G>T	c.(139-141)tGg>tTg	p.W47L	OGG1_ENST00000449570.2_Missense_Mutation_p.W47L|OGG1_ENST00000302008.8_Missense_Mutation_p.W47L|OGG1_ENST00000349503.5_Missense_Mutation_p.W47L|OGG1_ENST00000302003.7_Missense_Mutation_p.W47L|OGG1_ENST00000344629.7_Missense_Mutation_p.W47L|OGG1_ENST00000436092.1_3'UTR|OGG1_ENST00000339511.5_Missense_Mutation_p.W47L|OGG1_ENST00000383826.5_Missense_Mutation_p.W47L	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	47				W -> WW (in Ref. 9; CAA10351).	depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					GGGCTCAGGTGGAGGGAGCAA	0.522000								Base excision repair (BER), DNA glycosylases					16	42					6.94344e-10	7.90582e-10	0.175082	1	0
MVK	4598	broad.mit.edu	37	12	110034265	110034265	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:110034265G>T	ENST00000228510.3	+	11	1150	c.1074G>T	c.(1072-1074)caG>caT	p.Q358H	MVK_ENST00000392727.3_Missense_Mutation_p.Q306H|MVK_ENST00000541384.1_Missense_Mutation_p.Q164H|MVK_ENST00000539696.1_Missense_Mutation_p.Q77H|MVK_ENST00000539575.1_Missense_Mutation_p.Q306H	NM_000431.2|NM_001114185.1	NP_000422.1|NP_001107657.1	Q03426	KIME_HUMAN	mevalonate kinase	358					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|peroxisome	ATP binding|identical protein binding|mevalonate kinase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8						CCACGAAGCAGGCCCTGACCA	0.627000													23	4					1.04121e-07	1.14633e-07	0.324025	1	0
GPR112	139378	broad.mit.edu	37	X	135428676	135428676	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:135428676T>C	ENST00000394143.1	+	6	3102	c.2811T>C	c.(2809-2811)taT>taC	p.Y937Y	GPR112_ENST00000287534.4_Silent_p.Y874Y|GPR112_ENST00000412101.1_Silent_p.Y732Y|GPR112_ENST00000394141.1_Silent_p.Y732Y|GPR112_ENST00000370652.1_Silent_p.Y937Y	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	937					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ACCACACCTATGTAGCACATT	0.428000													457	51					0	0	0.323286	0	0
LOC100129345	100129345	broad.mit.edu	37	14	98099916	98099916	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:98099916G>T	ENST00000355909.3	-	0	737					NR_033943.1																						GTGTGCTGGGGACTGGGAATA	0.433000													8	39					6.40141e-05	6.75935e-05	0.080935	1	0
AHCTF1	25909	broad.mit.edu	37	1	247025437	247025437	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247025437T>G	ENST00000366508.1	-	28	3800	c.3664A>C	c.(3664-3666)Atg>Ctg	p.M1222L	AHCTF1_ENST00000326225.3_Missense_Mutation_p.M1196L|AHCTF1_ENST00000391829.2_Missense_Mutation_p.M1187L|AHCTF1_ENST00000470300.1_5'UTR			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	1187	Necessary for nuclear localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			GTAACTGACATGGCCAAACTT	0.468000													20	32					0	0	0.264190	0	0
KIAA0895	23366	broad.mit.edu	37	7	36423521	36423521	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:36423521C>G	ENST00000297063.6	-	2	175	c.125G>C	c.(124-126)aGa>aCa	p.R42T		NM_001100425.1	NP_001093895.1	Q8NCT3	K0895_HUMAN	KIAA0895	42	Arg-rich.									breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						ATGATTAGGTCTTGGCCTTTT	0.289000													14	53					0	0	0.175082	0	0
MGAT5	4249	broad.mit.edu	37	2	135099322	135099322	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:135099322G>T	ENST00000409645.1	+	8	1221	c.969G>T	c.(967-969)gaG>gaT	p.E323D	MGAT5_ENST00000281923.2_Missense_Mutation_p.E323D			Q09328	MGT5A_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase	323					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|pancreas(1)|skin(3)	36				BRCA - Breast invasive adenocarcinoma(221;0.0964)		CACTGGCTGAGCTCAAGGAGT	0.338000													73	50					1.45978e-39	2.35098e-39	0.323286	1	0
NUP205	23165	broad.mit.edu	37	7	135307617	135307617	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:135307617G>T	ENST00000285968.6	+	31	4449	c.4423G>T	c.(4423-4425)Gcc>Tcc	p.A1475S		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1475					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						AAGTTATGGCGCCGCCCTCAT	0.403000													36	43					5.48756e-27	7.96018e-27	0.301197	1	0
SERPINB11	89778	broad.mit.edu	37	18	61379924	61379924	+	RNA	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:61379924T>C	ENST00000544088.1	+	0	416				SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000489748.1_RNA|SERPINB11_ENST00000382749.5_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				TGGCATTTCATCAGGTAAGTC	0.438000													275	22					0	0	0.323286	0	0
FBN2	2201	broad.mit.edu	37	5	127693085	127693085	+	Missense_Mutation	SNP	T	T	A	rs148598779		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:127693085T>A	ENST00000508053.1	-	26	3531	c.2557A>T	c.(2557-2559)Ata>Tta	p.I853L	FBN2_ENST00000262464.4_Missense_Mutation_p.I853L|FBN2_ENST00000508989.1_Missense_Mutation_p.I820L			P35556	FBN2_HUMAN	fibrillin 2	853	EGF-like 13; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CATTCATTTATATCTACAATC	0.418000													37	49					0	0	0.214465	0	0
LRRN2	10446	broad.mit.edu	37	1	204588546	204588546	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:204588546T>C	ENST00000367175.1	-	1	2787	c.575A>G	c.(574-576)gAg>gGg	p.E192G	LRRN2_ENST00000367177.3_Missense_Mutation_p.E192G|LRRN2_ENST00000367176.3_Missense_Mutation_p.E192G			O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2	192					cell adhesion	integral to membrane	receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|liver(1)|lung(22)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	38	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			CATGAGTATCTCCAAGTTGGG	0.572000													47	122					0	0	0.323286	0	0
OR4A15	81328	broad.mit.edu	37	11	55136265	55136265	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55136265T>A	ENST00000314706.3	+	1	906	c.906T>A	c.(904-906)gtT>gtA	p.V302V		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						TGACTGTAGTTCTAACTTTTA	0.388000													230	144					0	0	0.323286	0	0
ZNF107	51427	broad.mit.edu	37	7	64168335	64168335	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:64168335C>A	ENST00000395391.1	+	4	3028	c.1653C>A	c.(1651-1653)ccC>ccA	p.P551P	ZNF107_ENST00000423627.1_Silent_p.P551P|ZNF107_ENST00000344930.3_Silent_p.P551P			Q9UII5	ZN107_HUMAN	zinc finger protein 107	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				GAGAGAAACCCTACAAATGTG	0.348000													28	84					1.04121e-07	1.14633e-07	0.324025	1	0
ZNF675	171392	broad.mit.edu	37	19	23836621	23836621	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:23836621C>A	ENST00000359788.4	-	4	1282	c.1114G>T	c.(1114-1116)Gaa>Taa	p.E372*	ZNF675_ENST00000601935.1_Intron|ZNF675_ENST00000600313.1_Intron|ZNF675_ENST00000596211.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	372					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTGCCGCATTCCTCACATTTG	0.378000													30	80					5.09552e-08	5.62797e-08	0.153744	1	0
EPAS1	2034	broad.mit.edu	37	2	46609131	46609131	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:46609131C>T	ENST00000263734.3	+	14	2700	c.2190C>T	c.(2188-2190)ggC>ggT	p.G730G		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	730					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CACCTGGTGGCAGCACCTCAC	0.587000													6	40					0	0	0.217242	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19856990	19856990	+	RNA	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:19856990T>C	ENST00000548109.1	+	0	72																											CACAGTGCTCTAAAAGCTCTG	0.398000													34	88					0	0	0.279185	0	0
CD97	976	broad.mit.edu	37	19	14515372	14515372	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:14515372G>A	ENST00000242786.5	+	13	1707	c.1627G>A	c.(1627-1629)Gag>Aag	p.E543K	CD97_ENST00000358600.3_Missense_Mutation_p.E450K|CD97_ENST00000357355.3_Missense_Mutation_p.E494K|CTC-548K16.5_ENST00000590626.1_RNA	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	543					cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TTATGACGTGGAGGTAAGTAG	0.577000													6	18					0	0	0.217242	0	0
SPARCL1	8404	broad.mit.edu	37	4	88415261	88415261	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:88415261T>G	ENST00000418378.1	-	5	1262	c.691A>C	c.(691-693)Agc>Cgc	p.S231R	SPARCL1_ENST00000503414.1_Missense_Mutation_p.S106R|SPARCL1_ENST00000282470.6_Missense_Mutation_p.S231R	NM_001128310.1	NP_001121782.1	Q14515	SPRL1_HUMAN	SPARC-like 1 (hevin)	231					signal transduction	extracellular space|proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(2)|stomach(2)	21				OV - Ovarian serous cystadenocarcinoma(123;0.00118)		TCCTGCTTGCTGTTAGCATGC	0.433000													21	190					0	0	0.219247	0	0
CASP7	840	broad.mit.edu	37	10	115485261	115485261	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:115485261A>C	ENST00000369321.2	+	6	936	c.616A>C	c.(616-618)Acc>Ccc	p.T206P	CASP7_ENST00000345633.4_Missense_Mutation_p.T173P|CASP7_ENST00000369331.4_Intron|CASP7_ENST00000369318.3_Missense_Mutation_p.T173P|CASP7_ENST00000452490.2_Missense_Mutation_p.T148P|CASP7_ENST00000369315.1_Missense_Mutation_p.T173P	NM_033338.5	NP_203124.1	P55210	CASP7_HUMAN	caspase 7, apoptosis-related cysteine peptidase	173					activation of caspase activity by cytochrome c|cellular component disassembly involved in apoptosis|induction of apoptosis by intracellular signals|proteolysis	cytosol|endoplasmic reticulum membrane|mitochondrial membrane|nucleoplasm	cysteine-type endopeptidase activity|protein binding			kidney(1)|large_intestine(1)|lung(5)|ovary(1)	8		Colorectal(252;0.0946)|Breast(234;0.188)		Epithelial(162;0.012)|all cancers(201;0.014)		TAGATGCAAAACCCTTTTAGA	0.408000													27	34					0	0	0.134883	0	0
PCDH17	27253	broad.mit.edu	37	13	58207066	58207066	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:58207066C>A	ENST00000377918.3	+	1	412	c.386C>A	c.(385-387)gCg>gAg	p.A129E		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	129	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AACGACAACGCGCCCTCCTTC	0.612000													16	19					2.94398e-08	3.26208e-08	0.189662	1	0
SIMC1	375484	broad.mit.edu	37	5	175717056	175717056	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:175717056C>T	ENST00000443967.1	+	4	879	c.472C>T	c.(472-474)Cag>Tag	p.Q158*	SIMC1_ENST00000503595.1_3'UTR|SIMC1_ENST00000430704.2_Intron|SIMC1_ENST00000341199.6_Intron|SIMC1_ENST00000429602.2_Nonsense_Mutation_p.Q177*					SUMO-interacting motifs containing 1																		GGCAAGTCTACAGCTGTCTTC	0.507000													19	24					0	0	0.309145	0	0
PGBD5	79605	broad.mit.edu	37	1	230468654	230468654	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:230468654C>A	ENST00000321327.2	-	7	1298	c.1299G>T	c.(1297-1299)ttG>ttT	p.L433F	PGBD5_ENST00000391860.1_Missense_Mutation_p.L288F|PGBD5_ENST00000530424.1_5'UTR|PGBD5_ENST00000525115.1_Missense_Mutation_p.L334F			Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	334						integral to membrane				biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(2)|skin(1)	33	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		ACCAGCAGATCAAGGACATGT	0.617000													49	142					4.1673e-28	6.10508e-28	0.323286	1	0
PCDH9	5101	broad.mit.edu	37	13	67205351	67205351	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:67205351G>T	ENST00000544246.1	-	4	4022	c.3331C>A	c.(3331-3333)Ccc>Acc	p.P1111T	PCDH9_ENST00000456367.1_Missense_Mutation_p.P1077T|PCDH9_ENST00000328454.5_Missense_Mutation_p.P1077T|PCDH9_ENST00000377865.2_Missense_Mutation_p.P1111T	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1111					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		CCAGAGTTGGGATCAGAGTTG	0.478000													36	61					3.33393e-15	4.1718e-15	0.214465	1	0
CCDC147	159686	broad.mit.edu	37	10	106139908	106139908	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:106139908G>T	ENST00000369704.3	+	9	1429	c.1295G>T	c.(1294-1296)aGa>aTa	p.R432I	CCDC147_ENST00000369703.1_Missense_Mutation_p.R54I|CCDC147_ENST00000312902.5_Missense_Mutation_p.R54I	NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	432										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		CAGAAGCAGAGAAAGATCATC	0.498000													160	23					5.43602e-54	9.32189e-54	0.323286	1	0
ZNF556	80032	broad.mit.edu	37	19	2877559	2877559	+	Missense_Mutation	SNP	A	A	C	rs144140574		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:2877559A>C	ENST00000586426.1	+	4	687	c.600A>C	c.(598-600)aaA>aaC	p.K200N	ZNF556_ENST00000307635.2_Missense_Mutation_p.K201N			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K201K(1)		endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGAGAGAAACCCTATGCCT	0.463000													6	85					0	0	0.248553	0	0
C10orf137	26098	broad.mit.edu	37	10	127408457	127408457	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:127408457G>T	ENST00000337623.3	+	1	186	c.81G>T	c.(79-81)caG>caT	p.Q27H	C10orf137_ENST00000356792.4_Missense_Mutation_p.Q27H	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	27					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TCCTGTCCCAGGGAGAATCCG	0.706000													5	3					0.184627	0.186433	0.184627	1	0
LYNX1	66004	broad.mit.edu	37	8	143846158	143846158	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:143846158C>A	ENST00000335822.5	-	5	888	c.259_splice	c.e5-1	p.R87_splice	LYNX1_ENST00000317543.7_Splice_Site_p.R53_splice|RP11-706C16.7_ENST00000523657.1_RNA|LYNX1_ENST00000523332.1_Intron	NM_023946.2	NP_076435.1	Q86SR0	SLUR2_HUMAN	Ly6/neurotoxin 1	53	UPAR/Ly6.					extracellular region				endometrium(1)|lung(2)|skin(1)	4	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					TGCTGAGGACCCCTGAGTGGG	0.627000													11	12					7.93312e-07	8.60556e-07	0.119110	1	0
SUMF1	285362	broad.mit.edu	37	3	4418015	4418015	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:4418015C>A	ENST00000272902.5	-	8	1048	c.1014_splice	c.e8+1	p.R338_splice	SUMF1_ENST00000458465.2_Splice_Site_p.R206_splice|SUMF1_ENST00000383843.5_Splice_Site_p.R313_splice|SUMF1_ENST00000534863.1_Splice_Site_p.R338_splice|SUMF1_ENST00000405420.2_Intron	NM_182760.3	NP_877437.2	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1	338						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(3)	13		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		ATGACTTACCCTATGGCACAT	0.423000													404	248					4.23829e-209	7.90247e-209	0.323286	1	0
PPP1R15A	23645	broad.mit.edu	37	19	49378904	49378904	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:49378904C>T	ENST00000200453.5	+	3	1968	c.1699C>T	c.(1699-1701)Ctg>Ttg	p.L567L		NM_014330.3	NP_055145.3	O75807	PR15A_HUMAN	protein phosphatase 1, regulatory subunit 15A	567	Interaction with SMARCB1.				apoptosis|cell cycle arrest|regulation of translation|response to DNA damage stimulus	endoplasmic reticulum	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(8)|skin(2)|urinary_tract(1)	23		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000244)|all cancers(93;0.000694)|GBM - Glioblastoma multiforme(486;0.0222)|Epithelial(262;0.033)		TGTCCATTTCCTGGCTGTCTG	0.697000													107	6					0	0	0.323286	0	0
KRTAP6-2	337967	broad.mit.edu	37	21	31971052	31971052	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:31971052A>C	ENST00000334897.3	-	1	167	c.142T>G	c.(142-144)Ttc>Gtc	p.F48V		NM_181604.1	NP_853635.1	Q3LI66	KRA62_HUMAN	keratin associated protein 6-2	48						intermediate filament				endometrium(2)|kidney(1)|large_intestine(4)|lung(4)	11						CCACAGAAGAAGCGGGAGCCG	0.552000													13	65					0	0	0.189662	0	0
C4orf45	152940	broad.mit.edu	37	4	159836423	159836423	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:159836423G>T	ENST00000434826.2	-	4	529	c.445C>A	c.(445-447)Cag>Aag	p.Q149K	C4orf45_ENST00000508011.1_5'UTR	NM_152543.2	NP_689756.2	Q96LM5	CD045_HUMAN	chromosome 4 open reading frame 45	149										large_intestine(2)|lung(3)	5						GAATTTCTCTGATCAGTGTCC	0.448000													33	6					6.00712e-18	7.79391e-18	0.163468	1	0
TAT	6898	broad.mit.edu	37	16	71604270	71604270	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:71604270G>T	ENST00000355962.4	-	9	1076	c.943C>A	c.(943-945)Cgc>Agc	p.R315S	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	315					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CCCAAAATGCGCTGACTCAGC	0.473000													39	83					5.2432e-18	6.81418e-18	0.323286	1	0
SI	6476	broad.mit.edu	37	3	164760931	164760931	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:164760931T>C	ENST00000264382.3	-	17	1982	c.1920A>G	c.(1918-1920)gaA>gaG	p.E640E		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	640	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTTCTGTGGTTTCAGCCACAA	0.363000										HNSCC(35;0.089)			37	109					0	0	0.246493	0	0
SPTBN4	57731	broad.mit.edu	37	19	41071434	41071434	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:41071434T>A	ENST00000352632.3	+	28	6107	c.6021T>A	c.(6019-6021)tcT>tcA	p.S2007S	SPTBN4_ENST00000392025.1_Silent_p.S750S|SPTBN4_ENST00000598249.1_Silent_p.S2007S|SPTBN4_ENST00000338932.3_Silent_p.S2007S			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2007					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGGGCGATCTCTGCTGCTCA	0.632000													32	1					0	0	0.257332	0	0
PCDH17	27253	broad.mit.edu	37	13	58207348	58207348	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:58207348G>T	ENST00000377918.3	+	1	694	c.668G>T	c.(667-669)cGt>cTt	p.R223L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	223	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GAGCCTCCACGTTCCGCCACC	0.587000													20	21					7.87624e-14	9.64139e-14	0.264190	1	0
GBE1	2632	broad.mit.edu	37	3	81720077	81720077	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:81720077T>C	ENST00000429644.2	-	3	984	c.341A>G	c.(340-342)tAc>tGc	p.Y114C	GBE1_ENST00000489715.1_Missense_Mutation_p.Y73C|GBE1_ENST00000477426.1_5'UTR	NM_000158.3	NP_000149.3	Q04446	GLGB_HUMAN	glucan (1,4-alpha-), branching enzyme 1	114					glucose metabolic process|glycogen biosynthetic process	cytosol	1,4-alpha-glucan branching enzyme activity|cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			breast(1)|endometrium(5)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Lung NSC(201;0.0117)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0654)|Epithelial(33;0.00305)|LUSC - Lung squamous cell carcinoma(29;0.00646)|BRCA - Breast invasive adenocarcinoma(55;0.00813)|Lung(72;0.0129)|KIRC - Kidney renal clear cell carcinoma(39;0.212)|Kidney(39;0.247)		CAGTTTTTTGTATGGGTACGA	0.348000									Glycogen Storage Disease, type IV				20	42					0	0	0.219247	0	0
ABCB5	340273	broad.mit.edu	37	7	20691042	20691042	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:20691042G>T	ENST00000404938.2	+	13	1984		c.e13-1		ABCB5_ENST00000443026.2_Splice_Site|ABCB5_ENST00000406935.1_Splice_Site|ABCB5_ENST00000477094.1_Splice_Site|ABCB5_ENST00000258738.6_Splice_Site	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5						regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TGGATTGGCAGATCATGGTGG	0.393000													23	63					1.22574e-08	1.36502e-08	0.249174	1	0
PCDHGB2	56103	broad.mit.edu	37	5	140740768	140740768	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140740768C>A	ENST00000522605.1	+	1	1066	c.1066C>A	c.(1066-1068)Cta>Ata	p.L356I	PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTACTCCCCTACCGGAGGA	0.458000													46	48					1.32667e-27	1.93351e-27	0.323286	1	0
TTBK1	84630	broad.mit.edu	37	6	43220497	43220497	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:43220497G>T	ENST00000259750.4	+	3	212	c.129G>T	c.(127-129)ggG>ggT	p.G43G	TTBK1_ENST00000304139.5_5'UTR	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	43	Protein kinase.					cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			TCGGGGGCGGGGGCTTTGGTG	0.587000													48	24					2.48254e-18	3.24133e-18	0.323286	1	0
SOX14	8403	broad.mit.edu	37	3	137483920	137483920	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:137483920C>A	ENST00000306087.1	+	1	342	c.294C>A	c.(292-294)taC>taA	p.Y98*		NM_004189.3	NP_004180.1	O95416	SOX14_HUMAN	SRY (sex determining region Y)-box 14	98					negative regulation of transcription from RNA polymerase II promoter|nervous system development|transcription, DNA-dependent	nucleus	sequence-specific DNA binding			large_intestine(2)|lung(12)	14						CCTTGCCCTACCTGGGCGACA	0.677000													36	89					7.63091e-17	9.76971e-17	0.257332	1	0
SIRPA	140885	broad.mit.edu	37	20	1902267	1902267	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:1902267C>A	ENST00000358771.4	+	3	815	c.663C>A	c.(661-663)gaC>gaA	p.D221E	SIRPA_ENST00000400068.3_Missense_Mutation_p.D221E|SIRPA_ENST00000356025.3_Missense_Mutation_p.D221E	NM_001040023.1	NP_001035112.1	P78324	SHPS1_HUMAN	signal-regulatory protein alpha	221	Ig-like C1-type 1.				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	21				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		CCCGCGAGGACGTTCACTCTC	0.592000													17	20					4.59853e-10	5.24554e-10	0.324025	1	0
NRXN1	9378	broad.mit.edu	37	2	50282164	50282164	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:50282164C>G	ENST00000404971.1	-	21	5196	c.3857G>C	c.(3856-3858)cGc>cCc	p.R1286P	NRXN1_ENST00000402717.3_Missense_Mutation_p.R1238P|NRXN1_ENST00000406316.2_Intron|NRXN1_ENST00000342183.5_Intron|NRXN1_ENST00000405472.3_Missense_Mutation_p.R1238P|NRXN1_ENST00000401669.2_Missense_Mutation_p.R1246P|NRXN1_ENST00000406859.3_Intron|NRXN1_ENST00000401710.1_Intron	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1239	Laminin G-like 6.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.R1287H(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AATCGCCAGGCGCTCGTTATC	0.338000													7	21					0	0	0.058154	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276782	71276782	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:71276782A>C	ENST00000398531.1	+	1	174	c.149A>C	c.(148-150)aAg>aCg	p.K50T	KRTAP5-10_ENST00000376536.4_Missense_Mutation_p.K50T	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	50	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGCTGCTGCAAGCCCGTGTGC	0.687000													39	122					0	0	0.323286	0	0
PLAG1	5324	broad.mit.edu	37	8	57078967	57078967	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:57078967C>T	ENST00000316981.3	-	5	1817	c.1338G>A	c.(1336-1338)caG>caA	p.Q446Q	PLAG1_ENST00000429357.2_Silent_p.Q446Q|PLAG1_ENST00000423799.2_Silent_p.Q364Q	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	446	Activates transcription; Inhibition of nuclear import due to lack of NLS and KPNA2 interaction.|Massively activates transcription.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GTGCTTCTTCCTGGGAATAGC	0.463000			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								64	65					0	0	0.323286	0	0
COL19A1	1310	broad.mit.edu	37	6	70897851	70897851	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:70897851G>T	ENST00000322773.4	+	47	3031	c.2929G>T	c.(2929-2931)Ggg>Tgg	p.G977W	COL19A1_ENST00000393344.1_Missense_Mutation_p.G599W	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	977	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						AGGCATGAAGGGGGCCATCGG	0.557000													146	70					2.05974e-71	3.66609e-71	0.323286	1	0
GBP5	115362	broad.mit.edu	37	1	89729611	89729611	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:89729611C>T	ENST00000343435.5	-	9	1706	c.1170G>A	c.(1168-1170)caG>caA	p.Q390Q	GBP5_ENST00000370459.3_Silent_p.Q390Q|RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000481145.1_5'UTR	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	390						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		AAATGTCATTCTGTTTTGCAT	0.368000													64	166					0	0	0.323286	0	0
CXorf40B	541578	broad.mit.edu	37	X	149101928	149101928	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:149101928C>A	ENST00000370406.3	-	4	993	c.165G>T	c.(163-165)gaG>gaT	p.E55D	CXorf40B_ENST00000462691.1_Missense_Mutation_p.E55D|CXorf40B_ENST00000355203.2_Missense_Mutation_p.E55D|CXorf40B_ENST00000370404.1_Missense_Mutation_p.E55D			Q96DE9	CX04B_HUMAN	chromosome X open reading frame 40B	55										endometrium(1)|lung(4)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CCACCAGCAGCTCCCGACAGG	0.587000													33	7					3.54561e-26	5.1002e-26	0.279185	1	0
RYR1	6261	broad.mit.edu	37	19	39018332	39018332	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:39018332G>A	ENST00000355481.4	+	72	10848	c.10717G>A	c.(10717-10719)Ggc>Agc	p.G3573S	RYR1_ENST00000359596.3_Missense_Mutation_p.G3578S|AC067969.1_ENST00000597015.1_RNA|RYR1_ENST00000360985.3_Missense_Mutation_p.G3578S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3578					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCTGTACCGGGGCGTCCCGGG	0.657000													14	24					0	0	0.175082	0	0
CORT	1325	broad.mit.edu	37	1	10510335	10510335	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:10510335G>T	ENST00000377049.3	+	1	560	c.55G>T	c.(55-57)Gct>Tct	p.A19S	APITD1-CORT_ENST00000400900.2_Intron|CORT_ENST00000320498.4_Missense_Mutation_p.A69S|APITD1_ENST00000602296.1_Intron|APITD1-CORT_ENST00000470413.2_Intron|APITD1-CORT_ENST00000465026.1_Intron|APITD1_ENST00000602787.1_Intron	NM_001302.4	NP_001293.3			cortistatin											breast(1)|endometrium(1)|stomach(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0487)		CACGGCCACCGCTGCCCTGCC	0.672000													5	6					0.0477658	0.0484859	0.307466	1	0
PPP3CC	5533	broad.mit.edu	37	8	22355572	22355572	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:22355572G>T	ENST00000240139.5	+	4	758	c.431G>T	c.(430-432)cGg>cTg	p.R144L	PPP3CC_ENST00000289963.8_Missense_Mutation_p.R144L|PPP3CC_ENST00000518852.1_Missense_Mutation_p.R144L|PPP3CC_ENST00000397775.3_Missense_Mutation_p.R144L	NM_005605.4	NP_005596.2	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma isozyme	144					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		TTTCTGCTTCGGGGAAATCAT	0.343000													30	9					1.56442e-22	2.16876e-22	0.163468	1	0
RAB4A	5867	broad.mit.edu	37	1	229424496	229424496	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:229424496A>T	ENST00000366690.4	+	3	341	c.133A>T	c.(133-135)Aca>Tca	p.T45S	RAB4A_ENST00000473894.1_Intron	NM_004578.2	NP_004569.2	P20338	RAB4A_HUMAN	RAB4A, member RAS oncogene family	40							GDP binding|GTP binding|GTPase activity			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.178)				CTCAAATCATACAATAGGAGT	0.303000													17	100					0	0	0.189662	0	0
DDX39B	7919	broad.mit.edu	37	6	31499075	31499075	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31499075C>A	ENST00000417556.2	-	9	1650	c.1020G>T	c.(1018-1020)gaG>gaT	p.E340D	DDX39B_ENST00000458640.1_Missense_Mutation_p.E325D|ATP6V1G2-DDX39B_ENST00000376185.1_3'UTR|DDX39B_ENST00000396172.1_Missense_Mutation_p.E325D|DDX39B_ENST00000376177.2_Missense_Mutation_p.E325D|DDX39B_ENST00000415382.2_Missense_Mutation_p.E247D			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	325	Helicase C-terminal.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						CAGCTCACCTCTCCTCCTGGG	0.483000													52	117					3.90926e-44	6.43303e-44	0.323286	1	0
SOX6	55553	broad.mit.edu	37	11	16010602	16010602	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:16010602C>T	ENST00000352083.6	-	14	1984	c.1907G>A	c.(1906-1908)aGg>aAg	p.R636K	SOX6_ENST00000527619.1_Missense_Mutation_p.R612K|SOX6_ENST00000316399.6_Missense_Mutation_p.R616K|SOX6_ENST00000528429.1_Missense_Mutation_p.R636K|SOX6_ENST00000528252.1_Missense_Mutation_p.R609K|SOX6_ENST00000396356.3_Missense_Mutation_p.R616K			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	636					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						GATTTTTCTCCTCTCATCCTT	0.527000											OREG0020800	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	56	116					0	0	0.323286	0	0
LAMA3	3909	broad.mit.edu	37	18	21474271	21474271	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:21474271A>G	ENST00000313654.9	+	43	5661	c.5420A>G	c.(5419-5421)aAc>aGc	p.N1807S	LAMA3_ENST00000269217.6_Missense_Mutation_p.N198S|LAMA3_ENST00000399516.3_Missense_Mutation_p.N1807S|LAMA3_ENST00000587184.1_Missense_Mutation_p.N198S	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1807	Domain III A.|Laminin EGF-like 15; truncated.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GACTGCATAAACCAAGAACCC	0.378000													125	175					0	0	0.323286	0	0
KCNH6	81033	broad.mit.edu	37	17	61615426	61615426	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:61615426C>A	ENST00000583023.1	+	7	1513	c.1501_splice	c.e7-1	p.S501_splice	KCNH6_ENST00000581784.1_Splice_Site_p.S448_splice|KCNH6_ENST00000314672.5_Splice_Site_p.S501_splice|KCNH6_ENST00000456941.2_Splice_Site_p.S448_splice	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	501					regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	CCGCCCCCAGCCCTGATGTAC	0.667000													8	17					0.000274275	0.000286389	0.307466	1	0
OSGEPL1	64172	broad.mit.edu	37	2	190619989	190619989	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:190619989A>T	ENST00000519810.1	-	4	861	c.519T>A	c.(517-519)ggT>ggA	p.G173G	OSGEPL1_ENST00000522700.1_Silent_p.G173G|OSGEPL1_ENST00000264151.5_Silent_p.G173G			Q9H4B0	OSGP2_HUMAN	O-sialoglycoprotein endopeptidase-like 1	173					proteolysis|tRNA processing		metalloendopeptidase activity			large_intestine(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0293)|all cancers(119;0.0831)			ACAGACAGTGACCTCCAGAAA	0.383000													14	140					0	0	0.119110	0	0
C20orf24	55969	broad.mit.edu	37	20	35238010	35238010	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:35238010C>T	ENST00000344795.3	+	3	443	c.225C>T	c.(223-225)tgC>tgT	p.C75C	C20orf24_ENST00000373852.5_Silent_p.C75C|C20orf24_ENST00000342422.3_Intron|TGIF2-C20orf24_ENST00000558530.1_Silent_p.C101C	NM_001199534.1|NM_018840.4	NP_001186463.1|NP_061328.1			chromosome 20 open reading frame 24											breast(1)|kidney(1)|lung(2)	4	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CCAGATTCTGCCTGATCAATG	0.478000													40	63					0	0	0.301197	0	0
CALCRL	10203	broad.mit.edu	37	2	188211006	188211006	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:188211006C>A	ENST00000409998.1	-	16	2072	c.1291G>T	c.(1291-1293)Ggt>Tgt	p.G431C	CALCRL_ENST00000392370.3_Missense_Mutation_p.G431C|AC007319.1_ENST00000412276.1_RNA|CALCRL_ENST00000410068.1_Missense_Mutation_p.G431C|AC007319.1_ENST00000453517.1_RNA			Q16602	CALRL_HUMAN	calcitonin receptor-like	431						integral to plasma membrane				endometrium(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(96;0.227)			TGACTATAACCTGGACCATCA	0.338000													18	77					1.37522e-17	1.77535e-17	0.189662	1	0
KIF15	56992	broad.mit.edu	37	3	44839103	44839103	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:44839103G>T	ENST00000326047.4	+	9	1059	c.910G>T	c.(910-912)Gac>Tac	p.D304Y		NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	304					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AGCACTTGTCGACGTGGGTAA	0.433000													141	94					9.55952e-61	1.67833e-60	0.323286	1	0
FH	2271	broad.mit.edu	37	1	241672065	241672065	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:241672065G>A	ENST00000366560.3	-	5	614	c.576C>T	c.(574-576)ccC>ccT	p.P192P		NM_000143.3	NP_000134.2	P07954	FUMH_HUMAN	fumarate hydratase	192					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(2)	26	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		GCATTGCTGTGGGAAAAGTAT	0.338000			"""Mis, N, F"""			"""lieomyomatosis, renal"""			Hereditary Leiomyomatosis and Renal Cell Cancer				23	83					0	0	0.279207	0	0
LRFN1	57622	broad.mit.edu	37	19	39805629	39805629	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:39805629C>A	ENST00000248668.4	-	1	347	c.348G>T	c.(346-348)cgG>cgT	p.R116R	CTC-246B18.8_ENST00000601911.1_RNA	NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	116						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GGTGCAGGGCCCGGAGGGCAC	0.682000													13	4					2.31682e-05	2.45474e-05	0.132662	1	0
KRTAP10-7	386675	broad.mit.edu	37	21	46021344	46021344	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:46021344T>G	ENST00000380102.2	+	1	848	c.823T>G	c.(823-825)Tgc>Ggc	p.C275G	TSPEAR_ENST00000323084.4_Intron	NM_198689.2	NP_941962.1	P60409	KR107_HUMAN	keratin associated protein 10-7	275	30 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						CGTGCCCGTCTGCTGTAAGCC	0.627000													90	148					0	0	0.323286	0	0
CDH12	1010	broad.mit.edu	37	5	21975417	21975417	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:21975417G>T	ENST00000382254.1	-	6	1395	c.309C>A	c.(307-309)acC>acA	p.T103T	CDH12_ENST00000522262.1_Silent_p.T103T|CDH12_ENST00000504376.2_Silent_p.T103T	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	103	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TTTCATCAATGGTAAAAACGG	0.483000										HNSCC(59;0.17)			152	198					4.8658e-77	8.70057e-77	0.323286	1	0
LAMP1	3916	broad.mit.edu	37	13	113960865	113960865	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:113960865A>G	ENST00000332556.4	+	2	321	c.127A>G	c.(127-129)Atg>Gtg	p.M43V	LAMP1_ENST00000397181.3_Missense_Mutation_p.M43V	NM_005561.3	NP_005552.3	P11279	LAMP1_HUMAN	lysosomal-associated membrane protein 1	43	First lumenal domain.					endosome membrane|integral to plasma membrane|lysosomal membrane|membrane fraction				NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(2)|prostate(1)|skin(1)|stomach(2)	16	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0482)|all_epithelial(44;0.0148)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			CGCGTGCATAATGGCCAACTT	0.507000													27	106					0	0	0.125774	0	0
APOB	338	broad.mit.edu	37	2	21226177	21226177	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:21226177G>T	ENST00000233242.1	-	29	12244	c.12117C>A	c.(12115-12117)ttC>ttA	p.F4039L		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4039					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACTCAGTTTTGAATATGGTGA	0.363000													116	199					9.0444e-51	1.52896e-50	0.323286	1	0
DNTT	1791	broad.mit.edu	37	10	98087245	98087245	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:98087245C>A	ENST00000419175.1	+	7	1065	c.895C>A	c.(895-897)Ctt>Att	p.L299I	DNTT_ENST00000371174.2_Missense_Mutation_p.L299I	NM_001017520.1|NM_004088.3	NP_001017520.1|NP_004079.3	P04053	TDT_HUMAN	DNA nucleotidylexotransferase	299	Mediates interaction with DNTTIP2.			L -> P (in Ref. 4; BAD97037).	DNA modification	nucleus	DNA binding|DNA nucleotidylexotransferase activity|DNA-directed DNA polymerase activity|metal ion binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	27		Colorectal(252;0.0815)|all_hematologic(284;0.224)		Epithelial(162;7.97e-08)|all cancers(201;1.89e-06)		TTATGAAGACCTTGTCAGCTG	0.512000													298	34					2.98194e-177	5.53994e-177	0.323286	1	0
ARIH2	10425	broad.mit.edu	37	3	48965034	48965034	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:48965034G>T	ENST00000356401.4	+	3	382	c.43G>T	c.(43-45)Gag>Tag	p.E15*	ARIH2_ENST00000449376.1_Nonsense_Mutation_p.E15*|ARIH2_ENST00000490095.1_Intron	NM_006321.2	NP_006312.1	O95376	ARI2_HUMAN	ariadne RBR E3 ubiquitin protein ligase 2	15	Asp/Glu-rich (acidic).				developmental cell growth|hemopoietic stem cell proliferation|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(193;9.42e-05)|Kidney(197;0.00258)|KIRC - Kidney renal clear cell carcinoma(197;0.00269)		CAGCAATGAAGAGGACTATGA	0.507000													20	29					2.89027e-11	3.38931e-11	0.249174	1	0
SYNRG	11276	broad.mit.edu	37	17	35898474	35898474	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:35898474C>A	ENST00000339208.6	-	18	3609	c.3469G>T	c.(3469-3471)Gtt>Ttt	p.V1157F	SYNRG_ENST00000394378.2_Missense_Mutation_p.V1079F|SYNRG_ENST00000591288.1_Missense_Mutation_p.V951F|SYNRG_ENST00000502449.2_Missense_Mutation_p.V1034F|SYNRG_ENST00000345615.4_Missense_Mutation_p.V1079F|SYNRG_ENST00000346661.4_Missense_Mutation_p.V1157F|SYNRG_ENST00000585472.1_Missense_Mutation_p.V1078F	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	1157					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TCTGTGCAAACAGAACTACTA	0.323000													77	188					1.11057e-38	1.77784e-38	0.323286	1	0
LAMA2	3908	broad.mit.edu	37	6	129835579	129835579	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:129835579C>A	ENST00000421865.2	+	64	9099	c.9050C>A	c.(9049-9051)cCa>cAa	p.P3017Q		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	3017	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GCTGGGGTTCCAGGGCATTTG	0.478000													46	112					2.13384e-23	2.98622e-23	0.323286	1	0
POTEE	445582	broad.mit.edu	37	2	131984435	131984435	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:131984435A>T	ENST00000356920.5	+	4	944	c.850A>T	c.(850-852)Aaa>Taa	p.K284*	PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_Nonsense_Mutation_p.K294*|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	284							ATP binding										ACATGAGCAAAAACAGCAAGT	0.328000													13	253					0	0	0.160694	0	0
ARSI	340075	broad.mit.edu	37	5	149677043	149677043	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:149677043G>A	ENST00000328668.7	-	2	2023	c.1444C>T	c.(1444-1446)Cct>Tct	p.P482S		NM_001012301.2	NP_001012301.1	Q5FYB1	ARSI_HUMAN	arylsulfatase family, member I	482						endoplasmic reticulum|extracellular region	arylsulfatase activity|metal ion binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	23			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ACCACATCAGGCCGCTGGCCA	0.627000													14	11					0	0	0.219247	0	0
GALNTL6	442117	broad.mit.edu	37	4	172735867	172735867	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:172735867C>A	ENST00000506823.1	+	2	793	c.136C>A	c.(136-138)Cag>Aag	p.Q46K	GALNTL6_ENST00000511251.1_Missense_Mutation_p.Q46K	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	46						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						CGGGGAGCAGCAGGTAAGTGC	0.542000													16	2					1.56452e-12	1.87078e-12	0.189662	1	0
RNF14	9604	broad.mit.edu	37	5	141354434	141354434	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:141354434G>T	ENST00000394520.2	+	4	529	c.220G>T	c.(220-222)Gtg>Ttg	p.V74L	RNF14_ENST00000394514.2_Intron|AC005740.5_ENST00000520882.1_RNA|RNF14_ENST00000394515.3_Missense_Mutation_p.V74L|RNF14_ENST00000356143.1_Missense_Mutation_p.V74L|RNF14_ENST00000347642.3_Missense_Mutation_p.V74L|RNF14_ENST00000540015.1_Intron|RNF14_ENST00000394519.1_Missense_Mutation_p.V74L|RNF14_ENST00000502341.1_Intron	NM_001201365.1|NM_004290.4	NP_001188294.1|NP_004281.1	Q9UBS8	RNF14_HUMAN	ring finger protein 14	74	RWD.				androgen receptor signaling pathway|positive regulation of transcription, DNA-dependent|protein ubiquitination|regulation of androgen receptor signaling pathway|regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|small conjugating protein ligase activity|transcription coactivator activity|zinc ion binding			cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15		all_hematologic(541;0.0536)|Ovarian(839;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.0407)		GCCTCCACTTGTGCTGAACTT	0.428000													65	81					5.98616e-33	9.23724e-33	0.323286	1	0
FOXG1	2290	broad.mit.edu	37	14	29237837	29237837	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:29237837T>A	ENST00000382535.3	+	2	1721	c.1352T>A	c.(1351-1353)cTg>cAg	p.L451Q	FOXG1_ENST00000313071.4_Missense_Mutation_p.L451Q			P55316	FOXG1_HUMAN	forkhead box G1	451					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CCCTCGACCCTGCCCTGTGAG	0.592000													20	36					0	0	0.249174	0	0
MYOD1	4654	broad.mit.edu	37	11	17741777	17741777	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:17741777C>A	ENST00000250003.3	+	1	663	c.448C>A	c.(448-450)Ctg>Atg	p.L150M		NM_002478.4	NP_002469.2	P15172	MYOD1_HUMAN	myogenic differentiation 1	150	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	17						GGTGGAGATCCTGCGCAACGC	0.672000													12	15					1.05317e-09	1.19563e-09	0.119110	1	0
LCT	3938	broad.mit.edu	37	2	136564957	136564957	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:136564957A>C	ENST00000264162.2	-	9	3924	c.3914T>G	c.(3913-3915)cTc>cGc	p.L1305R		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1305	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TATACCATCGAGCCTGTAGGC	0.527000													26	43					0	0	0.309145	0	0
SIGLEC15	284266	broad.mit.edu	37	18	43405708	43405708	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:43405708C>T	ENST00000389474.3	+	1	232	c.15C>T	c.(13-15)atC>atT	p.I5I		NM_213602.2	NP_998767.1	Q6ZMC9	SIG15_HUMAN	sialic acid binding Ig-like lectin 15	5						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4						AAAAGTCCATCTGGCTGCTGG	0.607000													111	9					0	0	0.323286	0	0
ZNF169	169841	broad.mit.edu	37	9	97062816	97062816	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:97062816G>T	ENST00000395395.2	+	5	1066	c.976G>T	c.(976-978)Ggc>Tgc	p.G326C	ZNF169_ENST00000340911.4_3'UTR	NM_194320.2	NP_919301.2	Q14929	ZN169_HUMAN	zinc finger protein 169	326						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	24		Acute lymphoblastic leukemia(62;0.136)				GTGTGGGCGAGGCTTTCGCCA	0.552000													67	62					6.07461e-23	8.46292e-23	0.323286	1	0
PCYT1B	9468	broad.mit.edu	37	X	24580058	24580058	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:24580058C>A	ENST00000492876.1	-	5	565		c.e5-1		PCYT1B_ENST00000356768.4_3'UTR|PCYT1B_ENST00000379144.2_3'UTR|PCYT1B_ENST00000379145.1_3'UTR			Q9Y5K3	PCY1B_HUMAN	phosphate cytidylyltransferase 1, choline, beta							endoplasmic reticulum	choline-phosphate cytidylyltransferase activity			breast(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	17					Choline(DB00122)	ACAGCCGCTGCCACAGGTGGT	0.537000													15	6					3.99206e-14	4.91001e-14	0.189662	1	0
AURKB	9212	broad.mit.edu	37	17	8110582	8110582	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:8110582C>A	ENST00000316199.6	-	5	390	c.313G>T	c.(313-315)Gcg>Tcg	p.A105S	AURKB_ENST00000578549.1_Intron|AURKB_ENST00000585124.1_Missense_Mutation_p.A104S|AURKB_ENST00000535053.1_Missense_Mutation_p.A105S|AURKB_ENST00000534871.1_Missense_Mutation_p.A63S			Q96GD4	AURKB_HUMAN	aurora kinase B	104	Protein kinase.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|mitotic prometaphase|protein localization to kinetochore	chromosome passenger complex|condensed nuclear chromosome, centromeric region|cytosol|spindle	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|lung(2)	4						ACCTTGAGCGCCACGATGAAA	0.522000													27	37					9.80776e-20	1.30363e-19	0.116897	1	0
CORIN	10699	broad.mit.edu	37	4	47788873	47788873	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:47788873C>A	ENST00000273857.4	-	3	277	c.278G>T	c.(277-279)gGg>gTg	p.G93V	CORIN_ENST00000505909.1_Missense_Mutation_p.G93V|CORIN_ENST00000508498.1_5'UTR|CORIN_ENST00000502252.1_Intron|CORIN_ENST00000504584.1_Missense_Mutation_p.G93V	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	93					peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						AACATCGGACCCTTGGATTTC	0.403000													26	24					2.44723e-14	3.02921e-14	0.309145	1	0
RP11-467H10.2	0	broad.mit.edu	37	7	76681186	76681186	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:76681186G>T	ENST00000459742.1	+	0	58																											ATCTCCCCTGGGTCCGGTGTT	0.468000													5	115					1.06961e-07	1.17509e-07	0.278610	1	0
SLC30A3	7781	broad.mit.edu	37	2	27480055	27480055	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:27480055C>A	ENST00000233535.4	-	5	1096	c.744G>T	c.(742-744)ggG>ggT	p.G248G	SLC30A3_ENST00000447008.2_Silent_p.G243G	NM_003459.4	NP_003450.2	Q99726	ZNT3_HUMAN	solute carrier family 30 (zinc transporter), member 3	248					regulation of sequestering of zinc ion	cell junction|integral to plasma membrane|late endosome|membrane fraction|synaptic vesicle membrane	zinc transporting ATPase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(11)|pancreas(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCCAGTACCCCAAAGCTCT	0.637000													4	42					0.000602214	0.000625229	0.184627	1	0
LCE5A	254910	broad.mit.edu	37	1	152484228	152484228	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152484228G>T	ENST00000334269.2	+	2	394	c.218G>T	c.(217-219)aGg>aTg	p.R73M		NM_178438.4	NP_848525.1	Q5TCM9	LCE5A_HUMAN	late cornified envelope 5A	73	Cys-rich.				keratinization					lung(3)|ovary(1)|prostate(3)	7	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCCACCACAGGCCCCGCCAG	0.672000													7	12					2.23348e-06	2.40595e-06	0.146539	1	0
TAF3	83860	broad.mit.edu	37	10	8006869	8006869	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:8006869A>G	ENST00000344293.5	+	3	1602	c.1396A>G	c.(1396-1398)Atg>Gtg	p.M466V		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	466					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CTCATGGACAATGGATGCCTC	0.473000													173	216					0	0	0.323286	0	0
DSC3	1825	broad.mit.edu	37	18	28574419	28574419	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:28574419C>A	ENST00000434452.1	-	16	2691		c.e16+1		DSC3_ENST00000360428.4_Intron	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3						homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			tttttatttaCCTTTTATGTT	0.249000													20	84					2.39187e-15	3.00269e-15	0.204396	1	0
PREX1	57580	broad.mit.edu	37	20	47266655	47266655	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:47266655G>A	ENST00000396220.1	-	24	2929	c.2907C>T	c.(2905-2907)ccC>ccT	p.P969P	PREX1_ENST00000371941.3_Silent_p.P969P			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	969					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGCAATTGGTGGGGCAGAAGT	0.597000													112	121					0	0	0.323286	0	0
MYH3	4621	broad.mit.edu	37	17	10539076	10539076	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:10539076C>A	ENST00000583535.1	-	29	4038	c.3951G>T	c.(3949-3951)aaG>aaT	p.K1317N	MYH3_ENST00000226209.7_Missense_Mutation_p.K1317N	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1317					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						CCAGCTGCCTCTTGAGCTCTT	0.433000													115	108					1.50762e-44	2.48488e-44	0.323286	1	0
PDCD4	27250	broad.mit.edu	37	10	112653952	112653952	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:112653952A>T	ENST00000393104.2	+	10	1421	c.1061A>T	c.(1060-1062)tAt>tTt	p.Y354F	PDCD4_ENST00000280154.7_Missense_Mutation_p.Y365F	NM_145341.3	NP_663314.1	Q53EL6	PDCD4_HUMAN	programmed cell death 4 (neoplastic transformation inhibitor)	365	MI 2.				apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	13		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GAGCTTGTATATGAAGTAAGA	0.333000													77	7					0	0	0.323286	0	0
LRP1B	53353	broad.mit.edu	37	2	141208192	141208192	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:141208192C>A	ENST00000389484.3	-	63	10973	c.10002G>T	c.(10000-10002)tgG>tgT	p.W3334C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3334	LDL-receptor class A 21.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTCACATTTCCACCAGAATG	0.338000										TSP Lung(27;0.18)			49	116					3.93605e-18	5.12183e-18	0.323286	1	0
SPEG	10290	broad.mit.edu	37	2	220326769	220326769	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220326769C>A	ENST00000312358.7	+	7	2738	c.2606C>A	c.(2605-2607)cCc>cAc	p.P869H	SPEG_ENST00000396698.1_Missense_Mutation_p.P765H|SPEG_ENST00000396688.1_Missense_Mutation_p.P20H|SPEG_ENST00000396686.1_Missense_Mutation_p.P20H|SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396689.2_Missense_Mutation_p.P20H|SPEG_ENST00000396695.2_Missense_Mutation_p.P77H	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	869	Ig-like 3.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AAGGCACCCCCCACCTTCAAG	0.647000													13	21					2.4624e-09	2.77512e-09	0.204396	1	0
CSRNP3	80034	broad.mit.edu	37	2	166532870	166532870	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:166532870C>G	ENST00000314499.7	+	6	833	c.457C>G	c.(457-459)Ctg>Gtg	p.L153V	CSRNP3_ENST00000342316.4_Missense_Mutation_p.L153V|CSRNP3_ENST00000409420.1_Missense_Mutation_p.L185V	NM_001172173.1	NP_001165644.1	Q8WYN3	CSRN3_HUMAN	cysteine-serine-rich nuclear protein 3	153					apoptosis|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(9)|lung(15)|ovary(3)|skin(2)	33						CACTCTTACACTGGATGACAT	0.408000													96	825					0	0	0.323286	0	0
NOD2	64127	broad.mit.edu	37	16	50756606	50756606	+	Missense_Mutation	SNP	A	A	G	rs75934273		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:50756606A>G	ENST00000300589.2	+	8	2893	c.2788A>G	c.(2788-2790)Agg>Ggg	p.R930G		NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	930					activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				CCAGAGCTTGAGGTGGCTCAG	0.542000													3	123					0	0	0.115264	0	0
DCUN1D1	54165	broad.mit.edu	37	3	182665025	182665025	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:182665025C>A	ENST00000292782.4	-	6	854		c.e6+1		DCUN1D1_ENST00000469954.1_Splice_Site	NM_020640.2	NP_065691.2	Q96GG9	DCNL1_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 1							ubiquitin ligase complex	protein binding			endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			ATTTTCATTACCTTCTTCATC	0.343000													19	25					5.35267e-07	5.83089e-07	0.189662	1	0
ITGB2	3689	broad.mit.edu	37	21	46310029	46310029	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:46310029T>A	ENST00000397850.2	-	13	1973	c.1521A>T	c.(1519-1521)tcA>tcT	p.S507S	ITGB2_ENST00000397854.3_Silent_p.S450S|ITGB2_ENST00000302347.5_Silent_p.S507S|ITGB2_ENST00000397852.1_Silent_p.S507S|ITGB2_ENST00000355153.4_Silent_p.S507S|ITGB2_ENST00000397857.1_Silent_p.S507S			P05107	ITB2_HUMAN	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	507	Cysteine-rich tandem repeats.				apoptosis|blood coagulation|cell-cell signaling|cell-matrix adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|multicellular organismal development|neutrophil chemotaxis|regulation of cell shape|regulation of immune response|regulation of peptidyl-tyrosine phosphorylation	integrin complex	glycoprotein binding|protein kinase binding|receptor activity			breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(4)|skin(3)	35				Colorectal(79;0.0669)	Simvastatin(DB00641)	CCCCCAGCCCTGAGCAGATGA	0.597000													10	0					0	0	0.080935	0	0
HTATSF1	27336	broad.mit.edu	37	X	135593311	135593311	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:135593311G>T	ENST00000535601.1	+	10	1829	c.1407G>T	c.(1405-1407)gaG>gaT	p.E469D	HTATSF1_ENST00000218364.4_Missense_Mutation_p.E469D	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	469	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					AATCTGAAGAGGGCTGCCCCA	0.463000													97	19					1.90545e-35	2.98341e-35	0.323286	1	0
STIM2	57620	broad.mit.edu	37	4	27019446	27019446	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:27019446G>T	ENST00000382009.3	+	12	2155	c.1888G>T	c.(1888-1890)Gcc>Tcc	p.A630S	STIM2_ENST00000412829.2_Missense_Mutation_p.A622S|STIM2_ENST00000237364.5_Missense_Mutation_p.A622S|STIM2_ENST00000465503.1_Missense_Mutation_p.A543S|STIM2_ENST00000467087.1_Missense_Mutation_p.A535S|STIM2_ENST00000467011.1_Missense_Mutation_p.A535S	NM_001169118.1	NP_001162589.1	Q9P246	STIM2_HUMAN	stromal interaction molecule 2	535					activation of store-operated calcium channel activity|calcium ion transport|cellular calcium ion homeostasis|negative regulation of calcium ion transport via store-operated calcium channel activity	endoplasmic reticulum membrane|integral to membrane|plasma membrane	calcium channel regulator activity|calcium ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	25		Breast(46;0.0503)				TGCTCCACACGCCCCCCACCC	0.622000													55	212					1.13205e-32	1.73906e-32	0.323286	1	0
NPAP1	23742	broad.mit.edu	37	15	24921603	24921603	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:24921603G>T	ENST00000329468.2	+	1	1063	c.589G>T	c.(589-591)Gac>Tac	p.D197Y		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CACCCAGGGAGACGTGGCCTC	0.592000													30	39					1.74807e-11	2.05612e-11	0.153744	1	0
MSX1	4487	broad.mit.edu	37	4	4864782	4864782	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:4864782C>A	ENST00000382723.4	+	2	1058	c.824C>A	c.(823-825)tCt>tAt	p.S275Y		NM_002448.3	NP_002439.2	P28360	MSX1_HUMAN	msh homeobox 1	269					apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		TACGGTGCCTCTGGCCCCTTC	0.706000													7	4					1.06961e-07	1.17509e-07	0.278610	1	0
SLIT2	9353	broad.mit.edu	37	4	20469422	20469422	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:20469422G>T	ENST00000504154.1	+	5	695	c.443G>T	c.(442-444)cGt>cTt	p.R148L	SLIT2_ENST00000273739.5_Missense_Mutation_p.R148L|SLIT2_ENST00000503823.1_Missense_Mutation_p.R148L|SLIT2_ENST00000503837.1_Missense_Mutation_p.R148L	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	148					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AAAGCTTTCCGTGGGGCAGTT	0.269000													6	31					0.00198382	0.00204251	0.248553	1	0
TRIOBP	11078	broad.mit.edu	37	22	38155175	38155175	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:38155175G>T	ENST00000406386.3	+	17	6483	c.6228G>T	c.(6226-6228)cgG>cgT	p.R2076R	TRIOBP_ENST00000407319.2_Silent_p.R363R|TRIOBP_ENST00000403663.2_Silent_p.R363R|RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2076					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					AGGCTCTTCGGGCCCAGCTGG	0.647000													15	1					1.99824e-07	2.18522e-07	0.160694	1	0
UBE3A	7337	broad.mit.edu	37	15	25601070	25601070	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:25601070T>A	ENST00000232165.3	-	9	2749	c.2093A>T	c.(2092-2094)gAt>gTt	p.D698V	UBE3A_ENST00000428984.2_Missense_Mutation_p.D678V|UBE3A_ENST00000438097.1_Missense_Mutation_p.D678V|UBE3A_ENST00000566215.1_Missense_Mutation_p.D678V|SNHG14_ENST00000554726.1_RNA|UBE3A_ENST00000397954.2_Missense_Mutation_p.D701V	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	701					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		TGGAATTTTATCACCATTTTC	0.308000													21	35					0	0	0.234183	0	0
C8orf74	203076	broad.mit.edu	37	8	10557834	10557834	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:10557834C>A	ENST00000304519.5	+	4	767	c.738C>A	c.(736-738)gcC>gcA	p.A246A	RP1L1_ENST00000329335.3_Intron	NM_001040032.1	NP_001035121.1	Q6P047	CH074_HUMAN	chromosome 8 open reading frame 74	246										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	13				COAD - Colon adenocarcinoma(149;0.0811)		ACACATTCGCCATCTTGGACC	0.602000													28	11					2.65835e-16	3.37829e-16	0.125774	1	0
APOBR	55911	broad.mit.edu	37	16	28508886	28508886	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:28508886G>T	ENST00000564831.1	+	2	2557	c.2524G>T	c.(2524-2526)Gag>Tag	p.E842*	APOBR_ENST00000431282.1_Nonsense_Mutation_p.E833*|APOBR_ENST00000328423.5_Nonsense_Mutation_p.E833*	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	833	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						AGGGCGGGTAGAGGCCGAGGA	0.647000													34	34					1.74807e-11	2.05612e-11	0.153744	1	0
CPN2	1370	broad.mit.edu	37	3	194062982	194062982	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:194062982G>T	ENST00000323830.3	-	2	539	c.450C>A	c.(448-450)ctC>ctA	p.L150L	CPN2_ENST00000429275.1_Silent_p.L150L	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	150					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		CCTGCAGGTGGAGGGACTCCA	0.632000													43	17					2.77807e-22	3.83408e-22	0.312237	1	0
SIRT4	23409	broad.mit.edu	37	12	120741790	120741790	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:120741790C>T	ENST00000202967.4	+	2	485	c.426C>T	c.(424-426)acC>acT	p.T142T	SIRT4_ENST00000537892.1_3'UTR	NM_012240.2	NP_036372.1	Q9Y6E7	SIRT4_HUMAN	sirtuin 4	142	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTTGGTGACCCAAAATGTGG	0.572000													9	32					0	0	0.093190	0	0
OR2G6	391211	broad.mit.edu	37	1	248685463	248685463	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248685463C>T	ENST00000343414.4	+	1	548	c.516C>T	c.(514-516)cgC>cgT	p.R172R		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	172					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGGTCATCGCACACTGGATC	0.552000													54	154					0	0	0.323286	0	0
KCNH8	131096	broad.mit.edu	37	3	19554502	19554502	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:19554502C>A	ENST00000328405.2	+	13	2386	c.2120C>A	c.(2119-2121)cCa>cAa	p.P707Q		NM_144633.2	NP_653234.2	Q96L42	KCNH8_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 8	707						integral to membrane	two-component sensor activity			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(3)|lung(37)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	77						AAGCGACTCCCATCCATTGTg	0.483000													42	110					1.02687e-29	1.52601e-29	0.312237	1	0
RSRC2	65117	broad.mit.edu	37	12	122992897	122992897	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:122992897G>A	ENST00000331738.7	-	8	1048	c.903C>T	c.(901-903)gcC>gcT	p.A301A	RSRC2_ENST00000354654.2_Silent_p.A253A|RSRC2_ENST00000392442.2_5'UTR	NM_023012.5	NP_075388.2	Q7L4I2	RSRC2_HUMAN	arginine/serine-rich coiled-coil 2	301								p.A301A(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|urinary_tract(2)	24	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.14e-05)|Epithelial(86;0.000183)|BRCA - Breast invasive adenocarcinoma(302;0.201)		TAGCTTGCAGGGCTGCCATCT	0.473000													33	24					0	0	0.214465	0	0
WNT5B	81029	broad.mit.edu	37	12	1755323	1755323	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:1755323G>T	ENST00000397196.2	+	5	1217	c.985G>T	c.(985-987)Gtg>Ttg	p.V329L	WNT5B_ENST00000545747.1_3'UTR|WNT5B_ENST00000537031.1_Missense_Mutation_p.V329L|WNT5B_ENST00000310594.3_Missense_Mutation_p.V329L	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	329					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			GTTCAAGAGCGTGCAGGTGGA	0.602000													3	21					0.00116845	0.00120784	0.217242	1	0
NCAM2	4685	broad.mit.edu	37	21	22664427	22664427	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:22664427G>T	ENST00000400546.1	+	5	734	c.485G>T	c.(484-486)cGg>cTg	p.R162L	NCAM2_ENST00000535285.1_Missense_Mutation_p.R187L|NCAM2_ENST00000486367.1_3'UTR|NCAM2_ENST00000284894.7_Missense_Mutation_p.R20L	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	162	Ig-like C2-type 2.				neuron cell-cell adhesion	integral to membrane|plasma membrane		p.R162P(1)		breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TTTCCAGATCGGTTCGCTATG	0.398000													47	65					1.67211e-32	2.56489e-32	0.323286	1	0
TVP23C	201158	broad.mit.edu	37	17	15441469	15441469	+	Splice_Site	SNP	C	C	T	rs139351610	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:15441469C>T	ENST00000584811.1	-	7	1815		c.e7-2		TVP23C_ENST00000428082.2_Splice_Site|TVP23C-CDRT4_ENST00000522212.2_Intron|TVP23C_ENST00000438826.3_Splice_Site|TVP23C_ENST00000519970.1_Intron|TVP23C_ENST00000225576.3_Intron					trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)																		TCCAGTGTTCCGCAAAAGACA	0.393000													3	59					0	0	0.115264	0	0
FGA	2243	broad.mit.edu	37	4	155506864	155506864	+	Missense_Mutation	SNP	G	G	T	rs121909613		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:155506864G>T	ENST00000302053.3	-	5	1795	c.1717C>A	c.(1717-1719)Cgt>Agt	p.R573S	FGA_ENST00000403106.3_Missense_Mutation_p.R573S	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	573			R -> C (in Dusart/Paris-5).|R -> L (in AMYL8).		platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GATTTACCACGGGAAGGGAAT	0.428000													43	25					1.03325e-14	1.28461e-14	0.301197	1	0
LRRC4B	94030	broad.mit.edu	37	19	51022252	51022252	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51022252G>T	ENST00000599957.1	-	3	915	c.718C>A	c.(718-720)Cgg>Agg	p.R240R	LRRC4B_ENST00000389201.3_Silent_p.R240R			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	240						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AGGTCCAGCCGGTTGCCCGAC	0.657000													16	8					5.26018e-13	6.34623e-13	0.234183	1	0
SYN1	6853	broad.mit.edu	37	X	47432343	47432343	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:47432343G>C	ENST00000295987.7	-	13	2162	c.2038C>G	c.(2038-2040)Ccc>Gcc	p.P680A	SYN1_ENST00000340666.4_Missense_Mutation_p.A667G	NM_006950.3	NP_008881.2	P17600	SYN1_HUMAN	synapsin I	680	E.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(6)|lung(6)|ovary(1)	21						CTAAGGCTGGGCCTGGGCGGG	0.597000													36	34					0	0	0.279185	0	0
ZEB2	9839	broad.mit.edu	37	2	145147418	145147418	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:145147418T>A	ENST00000558170.2	-	10	4429	c.3245A>T	c.(3244-3246)aAg>aTg	p.K1082M	ZEB2_ENST00000539609.3_Missense_Mutation_p.K1058M|ZEB2_ENST00000409487.3_Missense_Mutation_p.K1082M|ZEB2_ENST00000303660.4_Missense_Mutation_p.K1082M	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	1082						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		CGCCTCCCGCTTGCAGTAGGA	0.607000													34	68					0	0	0.301197	0	0
PON1	5444	broad.mit.edu	37	7	95024020	95024020	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:95024020C>A	ENST00000542556.1	-	2	91	c.81G>T	c.(79-81)agG>agT	p.R27S	PON3_ENST00000265627.5_Missense_Mutation_p.R27S|PON3_ENST00000475439.1_5'UTR|PON3_ENST00000427422.1_Missense_Mutation_p.R27S			P27169	PON1_HUMAN	paraoxonase 1	27					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	AGGCATTCACCCTTTCTCTGT	0.438000													20	76					4.35082e-09	4.87499e-09	0.219247	1	0
PCDHB7	56129	broad.mit.edu	37	5	140552680	140552680	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140552680G>A	ENST00000231137.3	+	1	438	c.264G>A	c.(262-264)gaG>gaA	p.E88E		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		88	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCTAAATGAGAAATTGGACC	0.463000													38	60					0	0	0.246493	0	0
NBN	4683	broad.mit.edu	37	8	90958406	90958406	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:90958406C>A	ENST00000265433.3	-	13	2186	c.2032G>T	c.(2032-2034)Gat>Tat	p.D678Y	NBN_ENST00000409330.1_Missense_Mutation_p.D596Y	NM_002485.4	NP_002476.2	O60934	NBN_HUMAN	nibrin	678					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(11;0.0344)			TGACCATAATCATCATTTATG	0.328000								Homologous recombination					42	42					2.45108e-15	3.06831e-15	0.268233	1	0
OCA2	4948	broad.mit.edu	37	15	28211920	28211920	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:28211920G>A	ENST00000354638.3	-	15	1707	c.1552C>T	c.(1552-1554)Ctt>Ttt	p.L518F	OCA2_ENST00000353809.5_Missense_Mutation_p.L494F|OCA2_ENST00000382996.2_Missense_Mutation_p.L518F	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	518					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGGAGAACAAGGCAAATCCCA	0.488000									Oculocutaneous Albinism				17	24					0	0	0.146539	0	0
RBAK	57786	broad.mit.edu	37	7	5104121	5104121	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:5104121A>T	ENST00000396912.1	+	5	1553	c.1034A>T	c.(1033-1035)tAc>tTc	p.Y345F	RBAK_ENST00000353796.3_Missense_Mutation_p.Y345F|RBAK_ENST00000396904.2_Intron|RBAK_ENST00000407184.1_Intron	NM_021163.3	NP_066986.1	Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	345					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		GAGAAACCCTACGAATGTAGC	0.438000													93	284					0	0	0.323286	0	0
KDM5C	8242	broad.mit.edu	37	X	53222185	53222185	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:53222185C>G	ENST00000375401.3	-	26	5179	c.4647G>C	c.(4645-4647)ctG>ctC	p.L1549L	KDM5C_ENST00000375379.3_Silent_p.L1546L|KDM5C_ENST00000375383.3_Silent_p.L1505L|KDM5C_ENST00000452825.3_Intron|KDM5C_ENST00000404049.3_Silent_p.L1548L	NM_004187.3	NP_004178.2	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	1549					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						GTGGGCAGGGCAGATGCAGCC	0.637000			"""N, F, S"""		clear cell renal carcinoma								40	2					0	0	0.323286	0	0
OR3A4P	390756	broad.mit.edu	37	17	3213964	3213964	+	RNA	SNP	C	C	A	rs145453911	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:3213964C>A	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							TGCTGACCATCATGGCCTATG	0.557000													99	18					4.85316e-53	8.29026e-53	0.323286	1	0
SLC39A12	221074	broad.mit.edu	37	10	18331665	18331665	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:18331665G>T	ENST00000377369.2	+	13	2252	c.1979G>T	c.(1978-1980)cGa>cTa	p.R660L	SLC39A12_ENST00000377371.3_Missense_Mutation_p.R659L|SLC39A12_ENST00000539911.1_Missense_Mutation_p.R526L|SLC39A12_ENST00000377374.4_Missense_Mutation_p.R623L	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	660					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						CAAACACAACGACCCTGGATG	0.368000													28	132					5.6714e-07	6.17593e-07	0.153744	1	0
MPDZ	8777	broad.mit.edu	37	9	13133860	13133860	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:13133860C>A	ENST00000319217.7	-	32	4674	c.4427G>T	c.(4426-4428)aGt>aTt	p.S1476I	MPDZ_ENST00000538841.1_Missense_Mutation_p.S335I|MPDZ_ENST00000381022.2_Missense_Mutation_p.S1476I|MPDZ_ENST00000536827.1_Missense_Mutation_p.S1443I|MPDZ_ENST00000381015.4_Missense_Mutation_p.S1476I|MPDZ_ENST00000541093.1_5'UTR|MPDZ_ENST00000447879.1_Missense_Mutation_p.S1443I|MPDZ_ENST00000546205.1_Missense_Mutation_p.S1490I|MPDZ_ENST00000541718.1_Missense_Mutation_p.S1476I	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	1476					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		TTTAAATGAACTGAGGTCCAC	0.393000													87	174					4.90379e-48	8.18708e-48	0.323286	1	0
NLGN4X	57502	broad.mit.edu	37	X	6069310	6069310	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:6069310G>T	ENST00000381095.3	-	2	825	c.198C>A	c.(196-198)atC>atA	p.I66I	NLGN4X_ENST00000469740.1_5'UTR|NLGN4X_ENST00000381092.1_Silent_p.I66I|NLGN4X_ENST00000381093.2_Silent_p.I66I|NLGN4X_ENST00000538097.1_Silent_p.I66I|NLGN4X_ENST00000275857.6_Silent_p.I66I	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	66					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						CTGGACCCAAGATCTCATTGG	0.552000													62	61					6.75472e-32	1.02848e-31	0.323286	1	0
EPPK1	83481	broad.mit.edu	37	8	144942206	144942206	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:144942206T>C	ENST00000525985.1	-	2	5287	c.5216A>G	c.(5215-5217)tAc>tGc	p.Y1739C				P58107	EPIPL_HUMAN	epiplakin 1	1739						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AAGCTGCAGGTACGTGAGGTT	0.577000													7	3					0	0	0.307466	0	0
LAMB3	3914	broad.mit.edu	37	1	209789870	209789870	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:209789870T>C	ENST00000391911.1	-	21	3717	c.3328A>G	c.(3328-3330)Aca>Gca	p.T1110A	LAMB3_ENST00000356082.4_Missense_Mutation_p.T1110A|LAMB3_ENST00000367030.3_Missense_Mutation_p.T1110A	NM_001017402.1	NP_001017402.1	Q13751	LAMB3_HUMAN	laminin, beta 3	1110	Domain I.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		TCTGCCTCTGTCTTCACACTC	0.512000													112	286					0	0	0.323286	0	0
LRRC23	10233	broad.mit.edu	37	12	7014888	7014888	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:7014888G>T	ENST00000007969.8	+	2	311	c.91G>T	c.(91-93)Gac>Tac	p.D31Y	LRRC23_ENST00000323702.5_Missense_Mutation_p.D31Y|LRRC23_ENST00000449039.1_3'UTR|LRRC23_ENST00000443597.2_Missense_Mutation_p.D31Y|LRRC23_ENST00000436789.1_Missense_Mutation_p.D31Y|LRRC23_ENST00000429740.1_Missense_Mutation_p.D31Y|LRRC23_ENST00000433346.1_Missense_Mutation_p.D31Y	NM_001135217.1|NM_201650.2	NP_001128689.1|NP_964013.1	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	31										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						ggagggggaggactacagaaa	0.542000													30	108					2.81731e-10	3.22678e-10	0.153744	1	0
DGKK	139189	broad.mit.edu	37	X	50167246	50167246	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:50167246C>A	ENST00000376025.2	-	0	815							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TATACATTACCGCGGGATGGT	0.413000													67	81					8.07507e-42	1.31209e-41	0.323286	1	0
FPR3	2359	broad.mit.edu	37	19	52327466	52327466	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:52327466C>A	ENST00000339223.4	+	2	644	c.465C>A	c.(463-465)gtC>gtA	p.V155V	FPR3_ENST00000595991.1_Silent_p.V155V	NM_002030.3	NP_002021.3	P25089	FPR3_HUMAN	formyl peptide receptor 3	155					cellular component movement|chemotaxis	integral to membrane|plasma membrane	N-formyl peptide receptor activity			NS(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(3)	35						TCACCATAGTCCTTACCTTAC	0.478000													114	331					6.34794e-51	1.07488e-50	0.323286	1	0
SCN7A	6332	broad.mit.edu	37	2	167327161	167327161	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:167327161T>G	ENST00000409855.1	-	6	754	c.628A>C	c.(628-630)Act>Cct	p.T210P		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	210					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						ATTCTCAAAGTTCTTGCAGTT	0.299000													6	55					0	0	0.278610	0	0
SYNE1	23345	broad.mit.edu	37	6	152782765	152782765	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:152782765C>G	ENST00000367255.5	-	21	2962	c.2361G>C	c.(2359-2361)gcG>gcC	p.A787A	SYNE1_ENST00000448038.1_Silent_p.A794A|SYNE1_ENST00000265368.4_Silent_p.A787A|SYNE1_ENST00000367248.3_Silent_p.A777A|SYNE1_ENST00000423061.1_Silent_p.A794A|SYNE1_ENST00000367253.4_Silent_p.A787A|SYNE1_ENST00000495090.2_Silent_p.A354A|SYNE1_ENST00000341594.5_Silent_p.A794A|SYNE1_ENST00000413186.2_Silent_p.A787A	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	787					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTGACATGGTCGCAAACATTT	0.443000										HNSCC(10;0.0054)			35	108					0	0	0.246493	0	0
VPS13B	157680	broad.mit.edu	37	8	100182286	100182286	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:100182286G>T	ENST00000395996.1	+	16	2339	c.2228G>T	c.(2227-2229)gGa>gTa	p.G743V	VPS13B_ENST00000357162.2_Missense_Mutation_p.G743V|VPS13B_ENST00000355155.1_Missense_Mutation_p.G743V|VPS13B_ENST00000521932.1_3'UTR|VPS13B_ENST00000358544.2_Missense_Mutation_p.G743V			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	743					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTCCAGGCAGGACTGACGTCT	0.398000													40	52					4.16155e-14	5.11441e-14	0.268233	1	0
IGSF21	84966	broad.mit.edu	37	1	18554472	18554472	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:18554472G>A	ENST00000251296.1	+	2	534	c.151G>A	c.(151-153)Gat>Aat	p.D51N		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	51	Ig-like 1.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CTTCAAGACAGATGGGCGCAT	0.567000													46	106					0	0	0.323286	0	0
SLITRK4	139065	broad.mit.edu	37	X	142717183	142717183	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:142717183G>T	ENST00000381779.4	-	2	1967	c.1742C>A	c.(1741-1743)cCc>cAc	p.P581H	SLITRK4_ENST00000356928.1_Missense_Mutation_p.P581H|SLITRK4_ENST00000338017.4_Missense_Mutation_p.P581H	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	581	LRRCT 2.					integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TAAAAGTTTGGGACATAAGAT	0.463000													50	6					8.72198e-27	1.25989e-26	0.323286	1	0
CDH5	1003	broad.mit.edu	37	16	66424346	66424346	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:66424346C>A	ENST00000341529.3	+	6	970	c.822C>A	c.(820-822)ggC>ggA	p.G274G	CDH5_ENST00000563425.2_Silent_p.G274G	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	274	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		CCCGTGTGGGCACCTCTGTGG	0.547000													15	39					2.23348e-06	2.40595e-06	0.146539	1	0
ZNF101	94039	broad.mit.edu	37	19	19790269	19790269	+	Silent	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19790269A>C	ENST00000592502.1	+	4	581	c.471A>C	c.(469-471)gcA>gcC	p.A157A	ZNF101_ENST00000444249.2_3'UTR|ZNF101_ENST00000415784.2_Silent_p.A37A			Q8IZC7	ZN101_HUMAN	zinc finger protein 101	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(2)|prostate(1)	17						GTAGTGGTGCACGGCGCACAG	0.478000													53	222					0	0	0.323286	0	0
TMEM132B	114795	broad.mit.edu	37	12	126135490	126135490	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:126135490C>A	ENST00000299308.3	+	7	1898	c.1890C>A	c.(1888-1890)acC>acA	p.T630T	TMEM132B_ENST00000535886.1_Silent_p.T142T	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	630						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CGGGAATAACCACGGTGCAGG	0.567000													52	5					2.73361e-28	4.01423e-28	0.323286	1	0
HEPHL1	341208	broad.mit.edu	37	11	93806538	93806538	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:93806538G>A	ENST00000315765.9	+	8	1445	c.1437G>A	c.(1435-1437)aaG>aaA	p.K479K		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	479	Plastocyanin-like 3.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				AAGCCGACAAGGTCTATAGCA	0.473000													34	74					0	0	0.183431	0	0
EEPD1	80820	broad.mit.edu	37	7	36327312	36327312	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:36327312A>T	ENST00000242108.4	+	6	1959	c.1241A>T	c.(1240-1242)gAg>gTg	p.E414V	EEPD1_ENST00000534978.1_Missense_Mutation_p.E414V	NM_030636.2	NP_085139.2	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family domain containing 1	414					DNA repair		DNA binding			endometrium(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|skin(1)	18						CTGGGGAGCGAGAATCCCAGC	0.552000													130	138					0	0	0.323286	0	0
MYBPC1	4604	broad.mit.edu	37	12	102078204	102078204	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:102078204T>A	ENST00000549145.1	+	30	3594		c.e30+2		MYBPC1_ENST00000441232.1_Splice_Site|MYBPC1_ENST00000553190.1_Splice_Site|MYBPC1_ENST00000541119.1_Splice_Site|MYBPC1_ENST00000550501.1_Splice_Site|MYBPC1_ENST00000547509.1_Splice_Site|MYBPC1_ENST00000547405.1_Splice_Site|MYBPC1_ENST00000361466.2_Splice_Site|MYBPC1_ENST00000551300.1_Splice_Site|MYBPC1_ENST00000360610.2_Splice_Site|MYBPC1_ENST00000452455.2_Intron|MYBPC1_ENST00000545503.2_Splice_Site|MYBPC1_ENST00000392934.3_Intron|MYBPC1_ENST00000361685.2_Splice_Site|MYBPC1_ENST00000536007.1_Splice_Site			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type						cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						TCATCTAAGGTAAGCTTTCAT	0.348000													21	34					0	0	0.249174	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43625222	43625222	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:43625222T>C	ENST00000332857.6	-	4	3493	c.3465A>G	c.(3463-3465)tcA>tcG	p.S1155S		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		AGTGGCTTACTGAAGGAGGCT	0.443000													73	488					0	0	0.323286	0	0
AZGP1P1	646282	broad.mit.edu	37	7	99578430	99578430	+	RNA	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:99578430T>A	ENST00000425474.1	+	0	46					NR_036679.1																						CTGTCTCTGCTGCTGCTTCTG	0.582000													37	122					0	0	0.268233	0	0
THRAP3	9967	broad.mit.edu	37	1	36757120	36757120	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:36757120A>T	ENST00000354618.5	+	6	2115	c.1891A>T	c.(1891-1893)Ata>Tta	p.I631L	THRAP3_ENST00000466743.1_3'UTR|THRAP3_ENST00000469141.2_Missense_Mutation_p.I631L	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	631					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGCCCAACATATAGTGACCAT	0.468000			T	USP6	aneurysmal bone cysts								105	76					0	0	0.323286	0	0
PKD1L1	168507	broad.mit.edu	37	7	47879177	47879177	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:47879177T>C	ENST00000289672.2	-	36	5686	c.5636A>G	c.(5635-5637)cAc>cGc	p.H1879R		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1879	PLAT.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CACCATCACGTGGCTGATGAA	0.662000													4	13					0	0	0.184627	0	0
C8A	731	broad.mit.edu	37	1	57347195	57347195	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:57347195A>T	ENST00000361249.3	+	5	638	c.542A>T	c.(541-543)tAc>tTc	p.Y181F		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	181	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GAGACGGTATACAATGGGGAA	0.463000													83	186					0	0	0.323286	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993473	140993473	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:140993473C>T	ENST00000285879.4	+	4	569	c.283C>T	c.(283-285)Cct>Tct	p.P95S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	95							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CACCCAGTCTCCTCTCCAGAA	0.577000										HNSCC(15;0.026)			258	26					0	0	0.323286	0	0
SAMD3	154075	broad.mit.edu	37	6	130505333	130505333	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:130505333C>A	ENST00000532763.1	-	6	693		c.e6-1		SAMD3_ENST00000457563.2_Splice_Site|SAMD3_ENST00000368134.2_Splice_Site|SAMD3_ENST00000324172.6_Splice_Site|SAMD3_ENST00000439090.2_Splice_Site|SAMD3_ENST00000533296.1_Splice_Site|SAMD3_ENST00000437477.2_Splice_Site			Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3											breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(15)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	29				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		GCTGGGGTACCTGTTCACCAA	0.453000													62	136					2.32817e-41	3.77505e-41	0.323286	1	0
FCRL5	83416	broad.mit.edu	37	1	157497566	157497566	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157497566A>G	ENST00000361835.3	-	9	1958	c.1801T>C	c.(1801-1803)Tat>Cat	p.Y601H	FCRL5_ENST00000368190.3_Missense_Mutation_p.Y601H|FCRL5_ENST00000356953.4_Missense_Mutation_p.Y601H|FCRL5_ENST00000368191.3_Missense_Mutation_p.Y516H	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	601	Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TCCTCATGATAAAACCAGTAC	0.582000													46	423					0	0	0.323286	0	0
CYTH4	27128	broad.mit.edu	37	22	37695348	37695348	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:37695348G>T	ENST00000248901.6	+	6	621		c.e6+1		CYTH4_ENST00000402997.1_Splice_Site|CYTH4_ENST00000439667.1_Splice_Site|CYTH4_ENST00000405206.3_Splice_Site	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4						regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						AGGCCCTCAGGTGAGTAGTCC	0.642000													42	3					8.4772e-36	1.33133e-35	0.323286	1	0
DGKB	1607	broad.mit.edu	37	7	14378218	14378218	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:14378218G>T	ENST00000403951.2	-	23	2466	c.2047C>A	c.(2047-2049)Cat>Aat	p.H683N	DGKB_ENST00000402815.1_Missense_Mutation_p.H682N|DGKB_ENST00000407950.1_Missense_Mutation_p.H675N|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000444700.2_Missense_Mutation_p.H664N|DGKB_ENST00000399322.3_Missense_Mutation_p.H683N|DGKB_ENST00000258767.5_Missense_Mutation_p.H683N|DGKB_ENST00000406247.3_Missense_Mutation_p.H683N			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	683					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	ATTCGTCGATGGCTTCGTCTT	0.393000													66	129					6.20995e-33	9.56827e-33	0.323286	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873626	91873626	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:91873626G>A	ENST00000373094.1	+	7	4576	c.3731G>A	c.(3730-3732)tGc>tAc	p.C1244Y	PCDH11X_ENST00000373097.1_Missense_Mutation_p.C1234Y|PCDH11X_ENST00000373088.1_Missense_Mutation_p.C1207Y|PCDH11X_ENST00000361655.2_Missense_Mutation_p.C1226Y|PCDH11X_ENST00000298274.8_Missense_Mutation_p.C1207Y|PCDH11X_ENST00000504220.1_3'UTR|PCDH11X_ENST00000406881.1_Missense_Mutation_p.C1236Y	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1244					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TCAGCCCTCTGCTACAGCCCT	0.577000													117	165					0	0	0.323286	0	0
MREG	55686	broad.mit.edu	37	2	216809647	216809647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:216809647C>A	ENST00000263268.6	-	5	879	c.584G>T	c.(583-585)gGg>gTg	p.G195V		NM_018000.2	NP_060470.2	Q8N565	MREG_HUMAN	melanoregulin	195						apical plasma membrane				large_intestine(1)|lung(2)	3		Renal(323;0.0328)		Epithelial(149;4.64e-07)|all cancers(144;5.56e-05)|LUSC - Lung squamous cell carcinoma(224;0.00832)|Lung(261;0.0111)		GCATGGAACCCCAGGCTTCTT	0.488000													64	63					2.69673e-31	4.07603e-31	0.323286	1	0
CNGA3	1261	broad.mit.edu	37	2	99012599	99012599	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:99012599T>C	ENST00000393504.1	+	8	1383	c.966T>C	c.(964-966)ttT>ttC	p.F322F	CNGA3_ENST00000272602.2_Silent_p.F322F|CNGA3_ENST00000436404.2_Silent_p.F304F|CNGA3_ENST00000409937.1_Silent_p.F326F	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	322					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						GCATCTACTTTGCCATTTCCA	0.478000													43	100					0	0	0.323286	0	0
EEPD1	80820	broad.mit.edu	37	7	36327311	36327311	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:36327311G>T	ENST00000242108.4	+	6	1958	c.1240G>T	c.(1240-1242)Gag>Tag	p.E414*	EEPD1_ENST00000534978.1_Nonsense_Mutation_p.E414*	NM_030636.2	NP_085139.2	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family domain containing 1	414					DNA repair		DNA binding			endometrium(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|skin(1)	18						CCTGGGGAGCGAGAATCCCAG	0.552000													130	139					1.42363e-81	2.56187e-81	0.323286	1	0
PRUNE	58497	broad.mit.edu	37	1	150997137	150997137	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:150997137C>A	ENST00000271620.3	+	4	542	c.386C>A	c.(385-387)cCc>cAc	p.P129H	PRUNE_ENST00000368937.1_Intron|PRUNE_ENST00000368935.1_Intron|PRUNE_ENST00000368936.1_5'UTR|PRUNE_ENST00000467771.1_3'UTR|PRUNE_ENST00000271619.8_Intron	NM_021222.1	NP_067045.1	Q86TP1	PRUNE_HUMAN	prune exopolyphosphatase	129						cytoplasm|focal adhesion|nucleus	inorganic diphosphatase activity|manganese ion binding|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	14	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GACCATCGACCCATCGAGCCG	0.577000											OREG0013792	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	57	51					1.80625e-27	2.62998e-27	0.323286	1	0
CCNY	219771	broad.mit.edu	37	10	35842023	35842023	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:35842023C>T	ENST00000374704.4	+	8	836	c.656C>T	c.(655-657)gCg>gTg	p.A219V	CCNY_ENST00000492478.1_3'UTR|CCNY_ENST00000265375.9_Missense_Mutation_p.A165V|CCNY_ENST00000374706.1_Missense_Mutation_p.A165V|CCNY_ENST00000339497.5_Missense_Mutation_p.A194V	NM_145012.4	NP_659449.3	Q8ND76	CCNY_HUMAN	cyclin Y	219	Cyclin N-terminal.				cell division|G2/M transition of mitotic cell cycle|positive regulation of cyclin-dependent protein kinase activity|regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasmic cyclin-dependent protein kinase holoenzyme complex|nucleus|plasma membrane	cyclin-dependent protein kinase regulator activity|protein kinase binding			cervix(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	8						GTTTTAGGGGCGATCCTGCTG	0.502000													47	123					0	0	0.323286	0	0
LARP6	55323	broad.mit.edu	37	15	71128757	71128757	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:71128757C>T	ENST00000299213.8	-	2	358	c.288G>A	c.(286-288)ctG>ctA	p.L96L		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	96	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						TCTGATCCACCAGTTTCTTGA	0.507000													49	131					0	0	0.323286	0	0
FRG2B	441581	broad.mit.edu	37	10	135440180	135440180	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:135440180G>T	ENST00000443774.1	-	1	116	c.67C>A	c.(67-69)Cct>Act	p.P23T	FRG2B_ENST00000425520.1_Missense_Mutation_p.P23T			Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	23						nucleus				endometrium(2)|kidney(2)|lung(14)|ovary(1)|prostate(1)	20		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TGTTGGAAAGGGGGCTGGTCA	0.498000													21	156					1.42536e-11	1.67909e-11	0.309145	1	0
OPRD1	4985	broad.mit.edu	37	1	29185797	29185797	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:29185797G>T	ENST00000234961.2	+	2	801	c.559G>T	c.(559-561)Gct>Tct	p.A187S		NM_000911.3	NP_000902.3	P41143	OPRD_HUMAN	opioid receptor, delta 1	187					immune response|protein import into nucleus, translocation	integral to plasma membrane	delta-opioid receptor activity|protein binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;0.000947)|all_lung(284;0.00131)|Renal(390;0.00758)|Breast(348;0.00765)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-07)|COAD - Colon adenocarcinoma(152;7.51e-06)|STAD - Stomach adenocarcinoma(196;0.00306)|BRCA - Breast invasive adenocarcinoma(304;0.0241)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)	Butorphanol(DB00611)|Codeine(DB00318)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Loperamide(DB00836)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pimozide(DB01100)|Propoxyphene(DB00647)	CATGGTCATGGCTGTGACCCG	0.612000													16	22					7.07596e-05	7.4589e-05	0.175082	1	0
SLC38A11	151258	broad.mit.edu	37	2	165802212	165802212	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:165802212T>G	ENST00000303735.4	-	3	417	c.87A>C	c.(85-87)aaA>aaC	p.K29N	SLC38A11_ENST00000409662.1_Missense_Mutation_p.K29N|SLC38A11_ENST00000409149.3_Missense_Mutation_p.K29N|SLC38A11_ENST00000409058.1_Missense_Mutation_p.K60N	NM_173512.2	NP_775783.1	Q08AI6	S38AB_HUMAN	solute carrier family 38, member 11	29					amino acid transport|sodium ion transport	integral to membrane				endometrium(2)|large_intestine(4)|lung(8)|ovary(1)	15						GGGCCCCTCCTTTTATCAATA	0.358000													71	224					0	0	0.323286	0	0
TGFBR3	7049	broad.mit.edu	37	1	92184870	92184870	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:92184870G>T	ENST00000212355.4	-	10	2030	c.1566_splice	c.e10+1	p.S522_splice	TGFBR3_ENST00000370399.2_Splice_Site_p.S521_splice|TGFBR3_ENST00000525962.1_Splice_Site_p.S522_splice	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	522	ZP.				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		AACACTCACGGAGTTATAGTA	0.488000													55	132					4.17463e-26	5.99389e-26	0.323286	1	0
CXorf66	347487	broad.mit.edu	37	X	139038576	139038576	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:139038576C>T	ENST00000370540.1	-	3	588	c.565G>A	c.(565-567)Gaa>Aaa	p.E189K		NM_001013403.2	NP_001013421.1	Q5JRM2	CX066_HUMAN	chromosome X open reading frame 66	189						integral to membrane				breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|skin(1)|stomach(1)	26						CATAATTTTTCTAGGCTGCCT	0.413000													91	12					0	0	0.323286	0	0
ASCC3	10973	broad.mit.edu	37	6	101090599	101090599	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:101090599C>A	ENST00000369162.2	-	24	4103	c.3759G>T	c.(3757-3759)ctG>ctT	p.L1253L		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1253	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTGTAAATACCAGTAGTTGGG	0.353000													82	54					9.35349e-44	1.53757e-43	0.323286	1	0
OTOGL	283310	broad.mit.edu	37	12	80651726	80651726	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:80651726A>T	ENST00000458043.2	+	17	1812	c.1806A>T	c.(1804-1806)aaA>aaT	p.K602N	OTOGL_ENST00000547103.1_Missense_Mutation_p.K602N	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GCGCATGGAAAAGAAGAACAT	0.333000													37	45					0	0	0.268233	0	0
ROBO1	6091	broad.mit.edu	37	3	78680311	78680311	+	Splice_Site	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:78680311C>G	ENST00000436010.2	-	23	4506	c.3509_splice	c.e23+1	p.S1170_splice	ROBO1_ENST00000467549.1_Splice_Site_p.S1109_splice|ROBO1_ENST00000464233.1_Splice_Site_p.S1209_splice|ROBO1_ENST00000495273.1_Splice_Site_p.S1164_splice			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1209					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		CTCCTCTTACCTTTCATCTAC	0.443000													17	42					0	0	0.189662	0	0
PTPRN	5798	broad.mit.edu	37	2	220161477	220161477	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220161477G>T	ENST00000295718.2	-	16	2544	c.2304C>A	c.(2302-2304)agC>agA	p.S768R	PTPRN_ENST00000409251.3_Missense_Mutation_p.S739R|PTPRN_ENST00000497977.1_5'UTR|PTPRN_ENST00000423636.2_Missense_Mutation_p.S678R	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	768	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		TCACAATGGGGCTGGCGTTGA	0.607000													11	83					1.08611e-07	1.19026e-07	0.080935	1	0
IMPG1	3617	broad.mit.edu	37	6	76660737	76660737	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:76660737T>A	ENST00000369950.3	-	13	1555	c.1366A>T	c.(1366-1368)Atc>Ttc	p.I456F	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	456					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AGAGAGAAGATGCTTGATGCC	0.478000													39	89					0	0	0.279185	0	0
TP53	7157	broad.mit.edu	37	17	7579375	7579375	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:7579375C>A	ENST00000420246.2	-	4	444	c.312G>T	c.(310-312)caG>caT	p.Q104H	TP53_ENST00000359597.4_Missense_Mutation_p.Q104H|TP53_ENST00000269305.4_Missense_Mutation_p.Q104H|TP53_ENST00000413465.2_Missense_Mutation_p.Q104H|TP53_ENST00000445888.2_Missense_Mutation_p.Q104H|TP53_ENST00000455263.2_Missense_Mutation_p.Q104H	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	104	Interaction with HIPK1 (By similarity).|Interaction with WWOX.		Q -> H (in sporadic cancers; somatic mutation).|Q -> L (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.Q100fs*37(3)|p.G59fs*23(3)|p.G105fs*18(2)|p.V73fs*9(1)|p.Q104H(1)|p.W91fs*13(1)|p.Y103_G112>C(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.Y103_L111>L(1)|p.Y103fs*15(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGTAGCTGCCCTGGTAGGTTT	0.632000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			90	126					3.52255e-68	6.2482e-68	0.323286	1	0
SSH2	85464	broad.mit.edu	37	17	27958698	27958698	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:27958698C>A	ENST00000269033.3	-	15	3584	c.3433G>T	c.(3433-3435)Gag>Tag	p.E1145*	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Nonsense_Mutation_p.E1172*	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	1145					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CTGCTCTGCTCTGTGAAGCCC	0.522000													36	95					1.60099e-16	2.03875e-16	0.214465	1	0
PKN2	5586	broad.mit.edu	37	1	89250387	89250387	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:89250387G>A	ENST00000370521.3	+	7	1410	c.1051G>A	c.(1051-1053)Gca>Aca	p.A351T	PKN2_ENST00000316005.7_Missense_Mutation_p.A351T|PKN2_ENST00000544045.1_Missense_Mutation_p.A25T|PKN2_ENST00000370513.5_Missense_Mutation_p.A351T|PKN2_ENST00000370505.3_Missense_Mutation_p.A194T	NM_006256.2	NP_006247.1	Q16513	PKN2_HUMAN	protein kinase N2	351	C2.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(1)	33		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		ACGGTCAAAAGCAACATCAGT	0.423000													21	68					0	0	0.234183	0	0
UBE2T	29089	broad.mit.edu	37	1	202304773	202304773	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:202304773C>A	ENST00000367274.4	-	2	259		c.e2+1			NM_014176.3	NP_054895.1	Q9NPD8	UBE2T_HUMAN	ubiquitin-conjugating enzyme E2T (putative)						DNA repair|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	nucleoplasm	ATP binding|ubiquitin-protein ligase activity			large_intestine(1)|lung(3)|skin(1)	5						TTGATACCTACGAGCTCGCAG	0.418000													42	155					1.7489e-18	2.28731e-18	0.301197	1	0
FAF1	11124	broad.mit.edu	37	1	51049383	51049383	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:51049383T>A	ENST00000396153.2	-	11	1423	c.972A>T	c.(970-972)ccA>ccT	p.P324P	FAF1_ENST00000371778.4_Silent_p.P324P|FAF1_ENST00000472808.1_5'UTR|FAF1_ENST00000545823.1_Silent_p.P82P	NM_007051.2	NP_008982.1	Q9UNN5	FAF1_HUMAN	Fas (TNFRSF6) associated factor 1	324					apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(1)		breast(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		CTGCGTTTTCTGGCACTAAAA	0.289000													19	29					0	0	0.219247	0	0
OR2L13	284521	broad.mit.edu	37	1	248263072	248263072	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248263072C>A	ENST00000366478.2	+	3	732	c.395C>A	c.(394-396)cCt>cAt	p.P132H	OR2L13_ENST00000358120.2_Missense_Mutation_p.P132H	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	132					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTCTATTATCCTATCCGCATG	0.483000													104	318					6.75489e-45	1.11454e-44	0.323286	1	0
DUSP11	8446	broad.mit.edu	37	2	74001052	74001052	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:74001052T>A	ENST00000443070.1	-	4	456		c.e4-2		DUSP11_ENST00000377706.4_Splice_Site|DUSP11_ENST00000272444.3_Splice_Site|DUSP11_ENST00000480948.1_Splice_Site			O75319	DUS11_HUMAN	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)						RNA processing	nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|skin(1)	12						TGGCAAATCCTATAAAGCAAA	0.313000													30	26					0	0	0.144211	0	0
SEPSECS	51091	broad.mit.edu	37	4	25160709	25160709	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:25160709G>A	ENST00000382103.2	-	2	207	c.135C>T	c.(133-135)ggC>ggT	p.G45G	SEPSECS_ENST00000302922.3_Intron	NM_016955.3	NP_058651.3	Q9HD40	SPCS_HUMAN	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	45					selenocysteine incorporation	cytoplasm|nucleus	pyridoxal phosphate binding|transferase activity, transferring selenium-containing groups|tRNA binding			endometrium(1)|large_intestine(4)|lung(2)|stomach(1)	8		Breast(46;0.173)			Pyridoxal Phosphate(DB00114)	TTTCATCCCAGCCATTCTCTG	0.353000													38	20					0	0	0.225048	0	0
TMEM177	80775	broad.mit.edu	37	2	120438478	120438478	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:120438478A>G	ENST00000424086.1	+	2	522	c.49A>G	c.(49-51)Aca>Gca	p.T17A	TMEM177_ENST00000496203.1_Intron|TMEM177_ENST00000401466.1_Missense_Mutation_p.T17A|TMEM177_ENST00000409951.1_Missense_Mutation_p.T17A|TMEM177_ENST00000272521.6_Missense_Mutation_p.T17A	NM_001105198.1	NP_001098668.1	Q53S58	TM177_HUMAN	transmembrane protein 177	17						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	13	Colorectal(110;0.196)					GAGACACAGGACAGGCCTCTT	0.572000													16	69					0	0	0.144211	0	0
ZNF365	22891	broad.mit.edu	37	10	64136068	64136068	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:64136068G>A	ENST00000395254.3	+	2	396	c.116G>A	c.(115-117)aGc>aAc	p.S39N	ZNF365_ENST00000410046.3_Missense_Mutation_p.S39N|ZNF365_ENST00000395255.3_Missense_Mutation_p.S39N|ZNF365_ENST00000466727.1_Intron	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					AGATTTAGAAGCTTGTCATCC	0.493000													11	10					0	0	0.069234	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167097	140167097	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140167097G>A	ENST00000504120.2	+	1	1222	c.1222G>A	c.(1222-1224)Gtg>Atg	p.V408M	PCDHA1_ENST00000378133.3_Missense_Mutation_p.V408M|PCDHA1_ENST00000394633.3_Missense_Mutation_p.V408M	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACTCGTTGGTGTTGGACAG	0.627000													65	78					0	0	0.323286	0	0
NYNRIN	57523	broad.mit.edu	37	14	24878083	24878083	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:24878083G>T	ENST00000382554.3	+	4	1401	c.1083G>T	c.(1081-1083)ccG>ccT	p.P361P		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	361					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						CATTGTGGCCGGGGGCTATTG	0.582000													37	44					8.73648e-17	1.11621e-16	0.203993	1	0
TAF1L	138474	broad.mit.edu	37	9	32631925	32631925	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:32631925G>T	ENST00000242310.4	-	1	3742	c.3653C>A	c.(3652-3654)aCt>aAt	p.T1218N		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1218					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		ATCTTTTGTAGTCCGTATGCG	0.433000													96	362					1.25439e-55	2.16184e-55	0.323286	1	0
FAT1	2195	broad.mit.edu	37	4	187630266	187630266	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:187630266C>A	ENST00000441802.2	-	2	925	c.716G>T	c.(715-717)aGc>aTc	p.S239I		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	239	Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CTTGGCCATGCTGCTGATGCC	0.512000										HNSCC(5;0.00058)			72	113					2.43199e-30	3.64563e-30	0.323286	1	0
ZNF521	25925	broad.mit.edu	37	18	22807491	22807491	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:22807491T>C	ENST00000361524.3	-	4	539	c.391A>G	c.(391-393)Agc>Ggc	p.S131G	ZNF521_ENST00000538137.2_Missense_Mutation_p.S131G|ZNF521_ENST00000584787.1_5'UTR	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	131					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TTTAGGTAGCTGAGGCGGCTA	0.522000			T	PAX5	ALL								100	383					0	0	0.323286	0	0
ANKRD30BP2	149992	broad.mit.edu	37	21	14414913	14414913	+	RNA	SNP	C	C	A	rs2821610	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:14414913C>A	ENST00000507941.1	+	0	95																											TCCTTGATGGCGAAAACAGGA	0.423000													4	45					0.150653	0.152375	0.150653	1	0
ESR2	2100	broad.mit.edu	37	14	64727411	64727411	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:64727411G>T	ENST00000557772.1	-	4	707	c.708C>A	c.(706-708)gaC>gaA	p.D236E	ESR2_ENST00000555483.1_5'UTR|ESR2_ENST00000555278.1_Missense_Mutation_p.D236E|ESR2_ENST00000554572.1_Missense_Mutation_p.D236E|ESR2_ENST00000553796.1_Missense_Mutation_p.D236E|ESR2_ENST00000542956.1_Missense_Mutation_p.D236E|ESR2_ENST00000358599.5_Missense_Mutation_p.D236E|ESR2_ENST00000357782.2_Missense_Mutation_p.D236E|ESR2_ENST00000341099.4_Missense_Mutation_p.D236E|ESR2_ENST00000353772.3_Missense_Mutation_p.D236E|ESR2_ENST00000267525.6_Missense_Mutation_p.D236E	NM_001214903.1	NP_001201832.1	Q92731	ESR2_HUMAN	estrogen receptor 2 (ER beta)	236	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	23				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	GCAGCTGCTCGTCGGCACTTC	0.637000													40	46					2.51966e-14	3.11761e-14	0.323286	1	0
PHOX2B	8929	broad.mit.edu	37	4	41749393	41749393	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:41749393C>G	ENST00000226382.2	-	2	761	c.402G>C	c.(400-402)aaG>aaC	p.K134N		NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	134					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						TGAGGTCGATCTTCAGGGCCA	0.657000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				12	42					0	0	0.093190	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2408556	2408556	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:2408556G>A	ENST00000332578.3	+	7	943	c.943G>A	c.(943-945)Gct>Act	p.A315T		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	315	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGCCTCCCGGCTGCCACACA	0.627000													12	32					0	0	0.132662	0	0
CCDC87	55231	broad.mit.edu	37	11	66358815	66358815	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66358815A>G	ENST00000333861.3	-	1	1739	c.1672T>C	c.(1672-1674)Tcc>Ccc	p.S558P		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	558										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						TTAGTATTGGACTGTAAAGTG	0.478000													48	29					0	0	0.323286	0	0
OPHN1	4983	broad.mit.edu	37	X	67283936	67283936	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:67283936T>A	ENST00000355520.5	-	21	2559	c.1918A>T	c.(1918-1920)Att>Ttt	p.I640F	OPHN1_ENST00000484842.1_5'UTR|OPHN1_ENST00000540071.1_Intron	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	640	Pro-rich.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						CTCCTCTGAATAGGTAGTTTG	0.522000													79	84					0	0	0.323286	0	0
ITIH5	80760	broad.mit.edu	37	10	7618494	7618494	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:7618494C>A	ENST00000256861.6	-	10	1978	c.1900G>T	c.(1900-1902)Gag>Tag	p.E634*	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397146.2_Nonsense_Mutation_p.E634*|ITIH5_ENST00000298441.6_Nonsense_Mutation_p.E420*|ITIH5_ENST00000446830.2_Nonsense_Mutation_p.E416*|ITIH5_ENST00000397145.2_Nonsense_Mutation_p.E634*	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	634					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						TGGGCCTCCTCCAGGCCATCC	0.697000													7	29					2.27111e-07	2.481e-07	0.093190	1	0
PRR21	643905	broad.mit.edu	37	2	240981395	240981395	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:240981395G>T	ENST00000408934.1	-	1	1004	c.1005C>A	c.(1003-1005)ttC>ttA	p.F335L		NM_001080835.1	NP_001074304.1	Q8WXC7	PRR21_HUMAN	proline rich 21	335										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(5)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	29						AGGCATGGATGAAGGGCCGTG	0.577000													118	97					2.22427e-50	3.74787e-50	0.323286	1	0
EGF	1950	broad.mit.edu	37	4	110884342	110884342	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:110884342C>T	ENST00000265171.5	+	9	1771	c.1326C>T	c.(1324-1326)ccC>ccT	p.P442P	EGF_ENST00000509793.1_Silent_p.P400P|EGF_ENST00000503392.1_Silent_p.P442P	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	442	EGF-like 4.				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity	p.P442P(2)		breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	GTTCCTCACCCGATAATGGTG	0.423000													95	85					0	0	0.323286	0	0
FAT3	120114	broad.mit.edu	37	11	92085369	92085369	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:92085369C>A	ENST00000298047.6	+	1	108	c.91C>A	c.(91-93)Cag>Aag	p.Q31K	FAT3_ENST00000541502.1_Missense_Mutation_p.Q31K|FAT3_ENST00000409404.2_Missense_Mutation_p.Q31K			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	31					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CACTGTCTCCCAGGGGCTGCC	0.517000										TCGA Ovarian(4;0.039)			33	16					2.09667e-21	2.85298e-21	0.193644	1	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338206	13338206	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:13338206C>A	ENST00000602906.1	+	0	224																				kidney(3)|lung(1)	4						ACCTTCTATTCCAACAAGGAG	0.448000													43	59					2.24722e-20	3.02199e-20	0.323286	1	0
BTBD11	121551	broad.mit.edu	37	12	107713182	107713182	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:107713182C>A	ENST00000280758.5	+	1	993	c.465C>A	c.(463-465)gcC>gcA	p.A155A	BTBD11_ENST00000420571.2_Silent_p.A155A|BTBD11_ENST00000490090.2_Silent_p.A155A	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	155						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TGCGCTTCGCCAAGTGCACCA	0.692000													4	6					0.00909568	0.00927843	0.150653	1	0
HFE2	148738	broad.mit.edu	37	1	145416854	145416854	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:145416854A>T	ENST00000336751.5	+	4	1437	c.1199A>T	c.(1198-1200)gAt>gTt	p.D400V	HFE2_ENST00000357836.5_Missense_Mutation_p.D287V|HFE2_ENST00000497365.1_Missense_Mutation_p.D174V|HFE2_ENST00000475797.1_Missense_Mutation_p.D174V	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	400					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCCCCTCAGATGCTGGGGTT	0.537000													20	42					0	0	0.249174	0	0
TM2D2	83877	broad.mit.edu	37	8	38848892	38848892	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:38848892G>A	ENST00000412303.1	-	4	869	c.475C>T	c.(475-477)Ctg>Ttg	p.L159L	TM2D2_ENST00000522434.1_5'UTR|TM2D2_ENST00000456397.2_Silent_p.L202L|TM2D2_ENST00000456845.2_Silent_p.L159L|TM2D2_ENST00000397070.2_Silent_p.L159L	NM_001024380.1|NM_001024381.1|NM_031940.3	NP_001019551.1|NP_001019552.1|NP_114146.3	Q9BX73	TM2D2_HUMAN	TM2 domain containing 2	202						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(2)	6		all_lung(54;0.00338)|Lung NSC(58;0.0133)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			CTTGGCATCAGCCCTCCAGTA	0.507000													19	4					0	0	0.175082	0	0
NMNAT2	23057	broad.mit.edu	37	1	183230190	183230190	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:183230190C>A	ENST00000287713.6	-	10	1102	c.768G>T	c.(766-768)gtG>gtT	p.V256V	NMNAT2_ENST00000294868.4_Silent_p.V251V	NM_015039.3	NP_055854.1	Q9BZQ4	NMNA2_HUMAN	nicotinamide nucleotide adenylyltransferase 2	256					water-soluble vitamin metabolic process	Golgi membrane|nucleus	ATP binding|nicotinamide-nucleotide adenylyltransferase activity|nicotinate-nucleotide adenylyltransferase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(7)|skin(2)	18						catccttcaccaccatgatgt	0.483000													127	89					1.40947e-82	2.53934e-82	0.323286	1	0
TRAV8-4	28682	broad.mit.edu	37	14	22362738	22362738	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:22362738G>T	ENST00000390438.2	+	0	126																											CCACTGCTCAGCCATGCTCCT	0.552000											OREG0022572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	90	137					4.70087e-54	8.07017e-54	0.323286	1	0
TXNDC11	51061	broad.mit.edu	37	16	11782228	11782228	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:11782228C>G	ENST00000356957.3	-	10	2162	c.2055G>C	c.(2053-2055)caG>caC	p.Q685H	TXNDC11_ENST00000570917.1_5'UTR|TXNDC11_ENST00000283033.5_Missense_Mutation_p.Q658H			Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	685	Thioredoxin 2.				cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						GAGACGGGAACTGGGCAGAGC	0.398000													48	9					0	0	0.323286	0	0
GAREM	64762	broad.mit.edu	37	18	29972987	29972987	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:29972987C>A	ENST00000399218.4	-	2	188	c.133G>T	c.(133-135)Gaa>Taa	p.E45*	GAREM_ENST00000269209.6_Nonsense_Mutation_p.E45*	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		CGCAGCCCTTCTACGCACTCT	0.423000													57	165					2.22609e-26	3.20511e-26	0.323286	1	0
ZNF430	80264	broad.mit.edu	37	19	21239530	21239530	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:21239530G>C	ENST00000261560.5	+	5	597	c.416G>C	c.(415-417)gGa>gCa	p.G139A		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						GGAAAATGTGGACATGAAGAT	0.373000													55	19					0	0	0.323286	0	0
PLEKHB1	58473	broad.mit.edu	37	11	73372606	73372606	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:73372606G>T	ENST00000354190.5	+	8	1122	c.691G>T	c.(691-693)Gcg>Tcg	p.A231S	PLEKHB1_ENST00000543085.1_Missense_Mutation_p.A126S|PLEKHB1_ENST00000535129.1_Missense_Mutation_p.A177S|PLEKHB1_ENST00000398492.4_Missense_Mutation_p.A196S|PLEKHB1_ENST00000398494.4_Missense_Mutation_p.A212S|PLEKHB1_ENST00000227214.6_Missense_Mutation_p.A177S	NM_021200.2	NP_067023.1	Q9UF11	PKHB1_HUMAN	pleckstrin homology domain containing, family B (evectins) member 1	231					multicellular organismal development|phototransduction	cytoplasm|integral to membrane	signal transducer activity			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	7						CGCCACTGGGGCGGCGCTGGG	0.682000											OREG0021217	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	46	76					1.78197e-24	2.51768e-24	0.323286	1	0
URB1	9875	broad.mit.edu	37	21	33756771	33756771	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:33756771C>G	ENST00000382751.3	-	3	400	c.285G>C	c.(283-285)acG>acC	p.T95T		NM_014825.2	NP_055640.2	O60287	NPA1P_HUMAN	URB1 ribosome biogenesis 1 homolog (S. cerevisiae)	95						nucleolus	protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(3)|skin(1)|stomach(1)	19						ATATTAACATCGTCTGCAAAG	0.383000													10	0					0	0	0.058154	0	0
RLF	6018	broad.mit.edu	37	1	40697321	40697321	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:40697321A>T	ENST00000372771.4	+	7	1107	c.1080A>T	c.(1078-1080)atA>atT	p.I360I		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	360					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			TTAGAGTTATACAAACTGAAG	0.393000													43	34					0	0	0.323286	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69094994	69094994	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:69094994C>T	ENST00000332644.5	-	8	1088	c.927G>A	c.(925-927)tgG>tgA	p.W309*		NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B	309	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						AAAGTGTTCCCCAACCTGTAA	0.328000													38	8					0	0	0.235728	0	0
RASAL2	9462	broad.mit.edu	37	1	178412287	178412287	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:178412287C>A	ENST00000448150.3	+	8	2169	c.1351C>A	c.(1351-1353)Cca>Aca	p.P451T	RASAL2_ENST00000367649.3_Missense_Mutation_p.P469T|RASAL2_ENST00000462775.1_Missense_Mutation_p.P321T	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	321	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						TGTCCTTGAGCCAGTAATTAG	0.433000													42	108					2.77807e-22	3.83408e-22	0.312237	1	0
CCDC88A	55704	broad.mit.edu	37	2	55563918	55563918	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:55563918G>A	ENST00000436346.1	-	14	2396	c.1555C>T	c.(1555-1557)Caa>Taa	p.Q519*	AC012358.8_ENST00000600219.1_RNA|AC012358.8_ENST00000599352.1_RNA|CCDC88A_ENST00000413716.2_Nonsense_Mutation_p.Q519*|CCDC88A_ENST00000336838.6_Nonsense_Mutation_p.Q519*|CCDC88A_ENST00000263630.8_Nonsense_Mutation_p.Q519*|AC012358.8_ENST00000599475.1_RNA|AC012358.8_ENST00000594078.1_RNA	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	519					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						TGAAGACTTTGCTTTTCTTGA	0.308000													11	17					0	0	0.080935	0	0
ZNF473	25888	broad.mit.edu	37	19	50549719	50549719	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:50549719C>T	ENST00000595661.1	+	6	2514	c.2019C>T	c.(2017-2019)ccC>ccT	p.P673P	ZNF473_ENST00000601364.1_Intron|ZNF473_ENST00000391821.2_Silent_p.P673P|ZNF473_ENST00000445728.3_Silent_p.P661P|ZNF473_ENST00000270617.3_Silent_p.P673P|CTD-2126E3.3_ENST00000599914.1_RNA|CTD-2126E3.3_ENST00000599410.1_RNA			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	673					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GAGAGAATCCCTTTAAATGTA	0.443000													55	45					0	0	0.323286	0	0
FER	2241	broad.mit.edu	37	5	108290505	108290505	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:108290505G>T	ENST00000281092.4	+	12	1789	c.1405G>T	c.(1405-1407)Gaa>Taa	p.E469*	FER_ENST00000438717.2_Nonsense_Mutation_p.E294*|FER_ENST00000536402.1_3'UTR	NM_005246.2	NP_005237.2	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	469	SH2.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			NS(2)|biliary_tract(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	32		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		TCCCAGAATAGAAGCTCAAGA	0.383000													32	27					4.4194e-11	5.16681e-11	0.173368	1	0
FLG2	388698	broad.mit.edu	37	1	152323416	152323416	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152323416T>G	ENST00000388718.5	-	3	6918	c.6846A>C	c.(6844-6846)caA>caC	p.Q2282H	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2282							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCTGTCTTTGTTGAGATCCAG	0.507000													124	333					0	0	0.323286	0	0
FOCAD	54914	broad.mit.edu	37	9	20912888	20912888	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:20912888G>A	ENST00000380249.1	+	25	3106	c.2742G>A	c.(2740-2742)ttG>ttA	p.L914L	FOCAD_ENST00000338382.6_Silent_p.L914L|FOCAD_ENST00000605086.1_Silent_p.L350L	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	914						integral to membrane	binding										AGCTGGAGTTGCAGTTAAAAC	0.418000													130	168					0	0	0.323286	0	0
TMEM104	54868	broad.mit.edu	37	17	72784942	72784942	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:72784942C>T	ENST00000335464.5	+	4	344	c.182C>T	c.(181-183)aCc>aTc	p.T61I	TMEM104_ENST00000417024.2_Missense_Mutation_p.T74I|TMEM104_ENST00000582330.1_Missense_Mutation_p.T61I|TMEM104_ENST00000582773.1_Missense_Mutation_p.T61I	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	61						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					GTGACCACCACCTTTGTGATA	0.592000													21	91					0	0	0.163468	0	0
CHRNA1	1134	broad.mit.edu	37	2	175618462	175618462	+	Missense_Mutation	SNP	C	C	G	rs145421881		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:175618462C>G	ENST00000348749.5	-	6	624	c.547G>C	c.(547-549)Gac>Cac	p.D183H	CHRNA1_ENST00000409219.1_Missense_Mutation_p.D183H|CHRNA1_ENST00000409323.1_Missense_Mutation_p.D183H|CHRNA1_ENST00000409542.1_Missense_Mutation_p.D101H|CHRNA1_ENST00000261007.5_Missense_Mutation_p.D208H|AC018890.6_ENST00000442996.1_RNA	NM_000079.3	NP_000070.1	P02708	ACHA_HUMAN	cholinergic receptor, nicotinic, alpha 1 (muscle)	208					muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(3)|prostate(3)|skin(4)	37						TCTGGCTGGTCGCTTTCCTGA	0.572000													28	29					0	0	0.134883	0	0
COL6A3	1293	broad.mit.edu	37	2	238283544	238283544	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:238283544G>A	ENST00000295550.4	-	8	3642	c.3190C>T	c.(3190-3192)Cgg>Tgg	p.R1064W	COL6A3_ENST00000346358.4_Missense_Mutation_p.R864W|COL6A3_ENST00000392004.3_Missense_Mutation_p.R858W|COL6A3_ENST00000472056.1_Missense_Mutation_p.R457W|COL6A3_ENST00000409809.1_Missense_Mutation_p.R858W|COL6A3_ENST00000392003.2_Missense_Mutation_p.R657W|COL6A3_ENST00000347401.3_Missense_Mutation_p.R863W|COL6A3_ENST00000353578.4_Missense_Mutation_p.R858W	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1064	Nonhelical region.|VWFA 6.		R -> Q (in UCMD).		axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.R1064W(2)|p.R858W(1)		breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACGCGGACCCGGTCCTGGCCC	0.592000													38	76					0	0	0.257332	0	0
SP4	6671	broad.mit.edu	37	7	21469849	21469849	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:21469849G>T	ENST00000222584.3	+	3	1284	c.1066G>T	c.(1066-1068)Gaa>Taa	p.E356*		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	356					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						CAGTAGTTCTGAACGCACCAT	0.488000													41	72					2.93687e-30	4.39821e-30	0.323286	1	0
SLC26A3	1811	broad.mit.edu	37	7	107415236	107415236	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:107415236G>C	ENST00000340010.5	-	16	1943	c.1759C>G	c.(1759-1761)Cta>Gta	p.L587V	SLC26A3_ENST00000422236.2_Missense_Mutation_p.L552V	NM_000111.2	NP_000102.1	P40879	S26A3_HUMAN	solute carrier family 26 (anion exchanger), member 3	587	STAS.				excretion	integral to membrane|membrane fraction	inorganic anion exchanger activity|secondary active sulfate transmembrane transporter activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(18)|ovary(4)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	46						GTCACTTGTAGCAAGCCTTGC	0.408000													48	158					0	0	0.323286	0	0
WDR35	57539	broad.mit.edu	37	2	20173448	20173448	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:20173448C>A	ENST00000345530.3	-	8	873	c.758G>T	c.(757-759)gGc>gTc	p.G253V	WDR35_ENST00000416055.2_5'UTR|WDR35_ENST00000281405.4_Missense_Mutation_p.G253V	NM_001006657.1	NP_001006658.1	Q9P2L0	WDR35_HUMAN	WD repeat domain 35	253										breast(1)|endometrium(5)|kidney(8)|large_intestine(8)|lung(16)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TACGTACATGCCAGTGTCAAT	0.448000													25	38					1.77063e-15	2.22822e-15	0.324025	1	0
SH3PXD2A	9644	broad.mit.edu	37	10	105372657	105372657	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:105372657T>A	ENST00000369774.4	-	12	1487	c.1211A>T	c.(1210-1212)cAg>cTg	p.Q404L	SH3PXD2A_ENST00000540321.1_Missense_Mutation_p.Q271L|SH3PXD2A_ENST00000427662.2_Missense_Mutation_p.Q266L|SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.Q376L|SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000538130.1_Missense_Mutation_p.Q239L			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	404					cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		TGGAGAGCCCTGGGCCAGCCT	0.612000													12	1					0	0	0.080935	0	0
RPL4	6124	broad.mit.edu	37	15	66794968	66794968	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:66794968C>G	ENST00000307961.6	-	4	495	c.403G>C	c.(403-405)Gca>Cca	p.A135P	RPL4_ENST00000568588.1_Missense_Mutation_p.A41P	NM_000968.3	NP_000959.2	P36578	RL4_HUMAN	ribosomal protein L4	135					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|stomach(1)|urinary_tract(1)	17						ATGACCAGTGCTGGTAGGGCT	0.428000													17	53					0	0	0.219247	0	0
WNT8B	7479	broad.mit.edu	37	10	102242450	102242450	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:102242450C>A	ENST00000343737.5	+	6	1061	c.933C>A	c.(931-933)tgC>tgA	p.C311*		NM_003393.3	NP_003384.2	Q93098	WNT8B_HUMAN	wingless-type MMTV integration site family, member 8B	311					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|determination of dorsal identity|endoderm development|eye development|gastrulation|hypothalamus development|negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway|otic placode formation|positive regulation of gene expression|response to estradiol stimulus|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|large_intestine(1)|ovary(1)|skin(1)	4		Colorectal(252;0.117)		Epithelial(162;1.87e-10)|all cancers(201;1.64e-08)		GCTGCAACTGCAAGTTCCACT	0.736000											OREG0020440	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	10					1.06961e-07	1.17509e-07	0.278610	1	0
CAPN9	10753	broad.mit.edu	37	1	230916350	230916350	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:230916350C>T	ENST00000354537.1	+	10	1381	c.1299C>T	c.(1297-1299)ttC>ttT	p.F433F	RP11-99J16__A.2_ENST00000412344.1_RNA|CAPN9_ENST00000366666.2_Silent_p.F396F|RP11-99J16__A.2_ENST00000428480.1_RNA|CAPN9_ENST00000271971.2_Silent_p.F459F|RP11-99J16__A.2_ENST00000452640.1_RNA	NM_016452.1	NP_057536.1	O14815	CAN9_HUMAN	calpain 9	459	Domain III.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity	p.F433L(1)		autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	25	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				CCGACCGGTTCAAGCTGCCCC	0.493000													86	238					0	0	0.323286	0	0
ABCB4	5244	broad.mit.edu	37	7	87076410	87076410	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:87076410G>T	ENST00000265723.4	-	9	1056	c.945C>A	c.(943-945)gcC>gcA	p.A315A	ABCB4_ENST00000545634.1_Silent_p.A315A|ABCB4_ENST00000453593.1_Silent_p.A315A|ABCB4_ENST00000359206.3_Silent_p.A315A|ABCB4_ENST00000358400.3_Silent_p.A315A	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	315	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CATACCAGAAGGCCAGTGCAT	0.328000													7	55					0.000157383	0.000164723	0.278610	1	0
UBAC1	10422	broad.mit.edu	37	9	138838168	138838168	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:138838168T>A	ENST00000371756.3	-	5	708	c.491A>T	c.(490-492)cAg>cTg	p.Q164L		NM_016172.2	NP_057256.2	Q9BSL1	UBAC1_HUMAN	UBA domain containing 1	164						Golgi apparatus|plasma membrane	protein binding			NS(1)|biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(2)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.1e-06)|Epithelial(140;7.79e-06)		TAACAGCTTCTGCGCCACCTC	0.498000													48	3					0	0	0.323286	0	0
MAGI1	9223	broad.mit.edu	37	3	65342156	65342156	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:65342156C>A	ENST00000402939.2	-	23	4285	c.4286G>T	c.(4285-4287)aGg>aTg	p.R1429M	MAGI1_ENST00000330909.8_3'UTR	NM_001033057.1	NP_001028229.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1458					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		CGCCTCTTCCCTTTCTCGGTG	0.602000													110	247					2.48225e-49	4.16894e-49	0.323286	1	0
AKAP4	8852	broad.mit.edu	37	X	49961636	49961636	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:49961636G>A	ENST00000376056.2	-	4	305	c.155C>T	c.(154-156)gCt>gTt	p.A52V	AKAP4_ENST00000376058.2_Missense_Mutation_p.A52V|AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000376064.3_Missense_Mutation_p.A52V|AKAP4_ENST00000358526.2_Missense_Mutation_p.A61V			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	61					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					GCTGGAACTAGCAGCATCCTA	0.413000													159	5					0	0	0.323286	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719148	140719148	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140719148G>C	ENST00000394576.2	+	1	610	c.610G>C	c.(610-612)Gaa>Caa	p.E204Q	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGACCGCGAGGAAGAGGCTGT	0.597000													59	63					0	0	0.323286	0	0
GCAT	23464	broad.mit.edu	37	22	38211699	38211699	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:38211699G>C	ENST00000323205.6	+	7	985	c.922G>C	c.(922-924)Gtg>Ctg	p.V308L	GCAT_ENST00000248924.6_Missense_Mutation_p.V282L	NM_001171690.1	NP_001165161.1	O75600	KBL_HUMAN	glycine C-acetyltransferase	282					biosynthetic process|cellular amino acid metabolic process		glycine C-acetyltransferase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	12	Melanoma(58;0.045)				Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	TGGGCCCCTGGTGTCCCTGCT	0.662000													27	6					0	0	0.225048	0	0
COL4A1	1282	broad.mit.edu	37	13	110822021	110822021	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:110822021G>T	ENST00000375820.4	-	43	3952	c.3831C>A	c.(3829-3831)ccC>ccA	p.P1277P		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1277	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTGGGACACCGGGTGCTCCTG	0.522000													31	112					1.414e-09	1.59999e-09	0.193644	1	0
CHRNB4	1143	broad.mit.edu	37	15	78917398	78917398	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:78917398C>A	ENST00000412074.2	-	5	706	c.595G>T	c.(595-597)Gat>Tat	p.D199Y	CHRNB4_ENST00000261751.3_3'UTR	NM_001256567.1	NP_001243496.1	P30926	ACHB4_HUMAN	cholinergic receptor, nicotinic, beta 4 (neuronal)	0					regulation of neurotransmitter secretion|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			endometrium(7)|kidney(1)|lung(13)|prostate(1)	22						AGGGCCTCATCAGCCACAACC	0.602000													21	57					1.10923e-09	1.25789e-09	0.264190	1	0
BIRC6	57448	broad.mit.edu	37	2	32724733	32724733	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:32724733T>C	ENST00000421745.2	+	46	8722	c.8588T>C	c.(8587-8589)gTt>gCt	p.V2863A		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	2863					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					ATAGAATCGGTTACATTTTTA	0.448000													10	135					0	0	0.160694	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20496622	20496622	+	RNA	SNP	A	A	T	rs2601530	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:20496622A>T	ENST00000555186.1	+	0	675					NR_038836.1																						AAGTGGCCTCATGAAGGGGAA	0.438000													9	62					0	0	0.069234	0	0
COL9A3	1299	broad.mit.edu	37	20	61468494	61468494	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:61468494C>G	ENST00000343916.3	+	30	1666	c.1663C>G	c.(1663-1665)Cgg>Ggg	p.R555G	COL9A3_ENST00000462700.1_3'UTR	NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	555	Triple-helical region 2 (COL2).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					GTCCATTGGTCGGCCCGGTCC	0.642000													36	121					0	0	0.279185	0	0
ATN1	1822	broad.mit.edu	37	12	7050065	7050065	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:7050065C>G	ENST00000356654.4	+	8	3474	c.3237C>G	c.(3235-3237)ctC>ctG	p.L1079L	ATN1_ENST00000396684.2_Silent_p.L1079L	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	1079					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						TGCACCCTCTCATTGACCCCC	0.597000													17	82					0	0	0.249174	0	0
SPZ1	84654	broad.mit.edu	37	5	79616340	79616340	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:79616340T>A	ENST00000296739.4	+	1	551	c.306T>A	c.(304-306)atT>atA	p.I102I		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAACCAATATTACTGAGGATG	0.333000													17	34					0	0	0.219247	0	0
NLRP4	147945	broad.mit.edu	37	19	56369394	56369394	+	Missense_Mutation	SNP	C	C	A	rs147162207	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:56369394C>A	ENST00000301295.6	+	3	1057	c.635C>A	c.(634-636)cCc>cAc	p.P212H	NLRP4_ENST00000346986.5_Missense_Mutation_p.P212H|NLRP4_ENST00000587891.1_Missense_Mutation_p.P137H	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	212	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TGGCCTGACCCCGCTGCTCCT	0.542000													104	9					1.45418e-49	2.44362e-49	0.323286	1	0
ZNF252P	286101	broad.mit.edu	37	8	146220352	146220352	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:146220352C>A	ENST00000426361.2	-	0	245					NR_023392.1															endometrium(1)	1						TGGGCCCCAGCTTGGTCCTCG	0.552000													29	38					4.3181e-19	5.70527e-19	0.173368	1	0
DPPA4	55211	broad.mit.edu	37	3	109050771	109050771	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:109050771G>T	ENST00000335658.6	-	3	340	c.286C>A	c.(286-288)Cgg>Agg	p.R96R	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	96						nucleus	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						AGAATGTCCCGGTGAATCAGA	0.542000													62	149					5.82218e-30	8.68559e-30	0.323286	1	0
GPR75	10936	broad.mit.edu	37	2	54081076	54081076	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:54081076C>A	ENST00000394705.2	-	2	1088	c.818G>T	c.(817-819)aGg>aTg	p.R273M	ASB3_ENST00000406625.2_Intron|ASB3_ENST00000498475.2_Intron|GPR75-ASB3_ENST00000352846.3_Intron	NM_006794.3	NP_006785.1	O95800	GPR75_HUMAN	G protein-coupled receptor 75	273						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ATTCTGGTTCCTATACAGAGC	0.552000													20	30					1.01871e-10	1.17942e-10	0.204396	1	0
OR51V1	283111	broad.mit.edu	37	11	5221133	5221133	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:5221133G>T	ENST00000321255.1	-	1	797	c.798C>A	c.(796-798)agC>agA	p.S266R		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCATTGTGAGGCTAATGATAG	0.488000													113	10					1.19107e-50	2.01132e-50	0.323286	1	0
ZNF385D	79750	broad.mit.edu	37	3	21478514	21478514	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:21478514C>A	ENST00000281523.2	-	5	1139	c.621G>T	c.(619-621)tcG>tcT	p.S207S	ZNF385D_ENST00000494118.1_5'UTR	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	207						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						CCTTGCATAGCGAACAGTAAA	0.478000													49	140					4.78724e-31	7.22167e-31	0.323286	1	0
HLA-B	3106	broad.mit.edu	37	6	31323175	31323175	+	Missense_Mutation	SNP	C	C	T	rs41558116		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31323175C>T	ENST00000412585.2	-	4	842	c.814G>A	c.(814-816)Gtg>Atg	p.V272M		NM_005514.6	NP_005505.2			major histocompatibility complex, class I, B											endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(4)|lung(4)|prostate(1)|upper_aerodigestive_tract(2)	27						GAAGGCACCACCACAGCTGCC	0.587000									Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of				4	132					0	0	0.307466	0	0
PTGS1	5742	broad.mit.edu	37	9	125154487	125154487	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:125154487A>G	ENST00000362012.2	+	11	1469	c.1464A>G	c.(1462-1464)gcA>gcG	p.A488A	PTGS1_ENST00000373698.5_Silent_p.A379A|PTGS1_ENST00000223423.4_Silent_p.A451A|PTGS1_ENST00000540753.1_Silent_p.A426A	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	488					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	AGATGGCAGCAGAGTTGGAGG	0.493000													25	14					0	0	0.116897	0	0
FAT4	79633	broad.mit.edu	37	4	126370776	126370776	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:126370776G>T	ENST00000394329.3	+	9	8618	c.8605G>T	c.(8605-8607)Gct>Tct	p.A2869S	FAT4_ENST00000335110.5_Missense_Mutation_p.A1167S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	2869	Cadherin 27.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAATGACAATGCTCCAAGATT	0.413000													55	32					7.77372e-23	1.08106e-22	0.323286	1	0
KIAA1755	85449	broad.mit.edu	37	20	36870209	36870209	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:36870209T>G	ENST00000279024.4	-	3	595	c.324A>C	c.(322-324)caA>caC	p.Q108H		NM_001029864.1	NP_001025035.1	Q5JYT7	K1755_HUMAN	KIAA1755	108										breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(5)|pancreas(2)|skin(4)|stomach(1)	54		Myeloproliferative disorder(115;0.00874)				GGGGCTCCACTTGGAGGTAGA	0.567000													151	513					0	0	0.323286	0	0
TRAV8-4	28682	broad.mit.edu	37	14	22362751	22362751	+	RNA	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:22362751T>C	ENST00000390438.2	+	0	139																											ATGCTCCTGCTGCTCGTCCCA	0.527000											OREG0022572	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	242					0	0	0.175082	0	0
OR51D1	390038	broad.mit.edu	37	11	4661117	4661117	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:4661117G>A	ENST00000357605.2	+	1	173	c.97G>A	c.(97-99)Ggg>Agg	p.G33R		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCTGGCCTGGGGCCTACCAT	0.512000													281	219					0	0	0.323286	0	0
TTN	7273	broad.mit.edu	37	2	179473550	179473550	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179473550A>G	ENST00000589042.1	-	274	52412	c.52188T>C	c.(52186-52188)gaT>gaC	p.D17396D	TTN_ENST00000342175.6_Silent_p.D8523D|TTN_ENST00000359218.5_Silent_p.D8456D|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Silent_p.D15755D|TTN_ENST00000460472.2_Silent_p.D8331D|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Silent_p.D14828D|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15755	Fibronectin type-III 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CACTGCCACCATCATCAAGGG	0.388000													163	180					0	0	0.323286	0	0
IRAK4	51135	broad.mit.edu	37	12	44180237	44180237	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:44180237G>T	ENST00000431837.1	+	10	1160	c.852G>T	c.(850-852)aaG>aaT	p.K284N	IRAK4_ENST00000448290.2_Missense_Mutation_p.K408N|IRAK4_ENST00000440781.2_Missense_Mutation_p.K284N|IRAK4_ENST00000551736.1_Missense_Mutation_p.K408N	NM_001145256.1|NM_001145257.1	NP_001138728.1|NP_001138729.1	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	408	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity					all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		ATGAAGAAAAGACAATTGAAG	0.274000													49	31					4.86159e-25	6.91293e-25	0.323286	1	0
DPP3	10072	broad.mit.edu	37	11	66262853	66262853	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66262853G>T	ENST00000532677.1	+	14	1928	c.1527G>T	c.(1525-1527)cgG>cgT	p.R509R	DPP3_ENST00000531863.1_Silent_p.R510R|DPP3_ENST00000360510.2_Silent_p.R490R|DPP3_ENST00000530165.1_Silent_p.R460R|DPP3_ENST00000453114.1_Silent_p.R490R|DPP3_ENST00000541961.1_Silent_p.R490R|DPP3_ENST00000533799.1_3'UTR	NM_001256670.1|NM_005700.4|NM_130443.3	NP_001243599.1|NP_005691.2|NP_569710.2	Q9NY33	DPP3_HUMAN	dipeptidyl-peptidase 3	490					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)	23						GCTGGTATCGGAGCGGGGAGA	0.622000													9	20					9.70103e-10	1.10294e-09	0.069234	1	0
ZNF527	84503	broad.mit.edu	37	19	37880419	37880419	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:37880419A>G	ENST00000436120.2	+	5	1575	c.1468A>G	c.(1468-1470)Aga>Gga	p.R490G	ZNF527_ENST00000587349.1_Intron	NM_032453.1	NP_115829.1	Q8NB42	ZN527_HUMAN	zinc finger protein 527	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	33			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCGACATCATAGAATTCACAC	0.398000													60	131					0	0	0.323286	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100537704	100537704	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:100537704G>C	ENST00000268070.4	-	19	2787	c.2682C>G	c.(2680-2682)aaC>aaG	p.N894K		NM_139057.2	NP_620688.2	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 17	894	TSP type-1 3.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)	50	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		CGTGTGTGCCGTTCTGCAGCT	0.697000													14	13					0	0	0.132662	0	0
TTYH1	57348	broad.mit.edu	37	19	54940550	54940550	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:54940550C>A	ENST00000301194.4	+	6	922	c.800C>A	c.(799-801)aCg>aAg	p.T267K	TTYH1_ENST00000391739.3_Missense_Mutation_p.T316K|TTYH1_ENST00000376531.3_Missense_Mutation_p.T267K|TTYH1_ENST00000489425.1_3'UTR|TTYH1_ENST00000376530.3_Missense_Mutation_p.T267K			Q9H313	TTYH1_HUMAN	tweety family member 1	267					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		GAGGCAGCCACGGCCGTGGTG	0.627000													22	23					4.4004e-07	4.79692e-07	0.279207	1	0
ACER2	340485	broad.mit.edu	37	9	19424711	19424711	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:19424711C>A	ENST00000340967.2	+	3	263	c.237C>A	c.(235-237)gtC>gtA	p.V79V	ACER2_ENST00000380376.1_Silent_p.V30V	NM_001010887.2	NP_001010887.2	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	79					ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	13						TTGGATCCGTCTACTTCCATG	0.423000													181	388					5.33936e-108	9.79621e-108	0.323286	1	0
NELL2	4753	broad.mit.edu	37	12	45171087	45171087	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:45171087T>A	ENST00000429094.2	-	6	1121	c.617A>T	c.(616-618)cAa>cTa	p.Q206L	NELL2_ENST00000437801.2_Missense_Mutation_p.Q256L|NELL2_ENST00000549027.1_Missense_Mutation_p.Q205L|NELL2_ENST00000551601.1_Missense_Mutation_p.Q205L|NELL2_ENST00000395487.2_Missense_Mutation_p.Q205L|NELL2_ENST00000452445.2_Missense_Mutation_p.Q206L|NELL2_ENST00000333837.4_Missense_Mutation_p.Q229L	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	206	TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TTGGACATCTTGCATTATACC	0.363000													86	55					0	0	0.323286	0	0
RYR3	6263	broad.mit.edu	37	15	34123242	34123242	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:34123242G>A	ENST00000389232.4	+	86	11483	c.11413G>A	c.(11413-11415)Gct>Act	p.A3805T	RYR3_ENST00000415757.3_Missense_Mutation_p.A3800T	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3805					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTTTTCCAAAGCTCTGGCAGT	0.373000													49	9					0	0	0.323286	0	0
COL4A2	1284	broad.mit.edu	37	13	111143618	111143618	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:111143618G>T	ENST00000360467.5	+	37	3691	c.3385G>T	c.(3385-3387)Gac>Tac	p.D1129Y		NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1129	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			AACAGAAGGTGACATCGGCTT	0.547000													3	16					0.014758	0.0150347	0.184627	1	0
GRK4	2868	broad.mit.edu	37	4	3029698	3029698	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:3029698C>T	ENST00000398052.4	+	11	1373	c.1030C>T	c.(1030-1032)Cga>Tga	p.R344*	GRK4_ENST00000509545.1_3'UTR|GRK4_ENST00000398051.4_Nonsense_Mutation_p.R312*|GRK4_ENST00000504933.1_Nonsense_Mutation_p.R344*|GRK4_ENST00000345167.6_Nonsense_Mutation_p.R312*	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	344	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity	p.R344*(1)		lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACAGAGGGTTCGAGGAAGAGT	0.522000													7	57					0	0	0.278610	0	0
KCNMB1	3779	broad.mit.edu	37	5	169810651	169810651	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:169810651A>C	ENST00000521859.1	-	3	737	c.338T>G	c.(337-339)cTt>cGt	p.L113R	KCNIP1_ENST00000377360.4_Intron|KCNIP1_ENST00000518527.1_Intron|KCNMB1_ENST00000274629.4_Intron			Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 1	0					platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			endometrium(1)|large_intestine(1)|lung(7)|ovary(2)	11	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		ACAGGGATAAAGGGATGTGTC	0.572000													21	22					0	0	0.249174	0	0
DHRS7	51635	broad.mit.edu	37	14	60619815	60619815	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:60619815T>C	ENST00000216500.5	-	5	930	c.475A>G	c.(475-477)Ata>Gta	p.I159V	DHRS7_ENST00000536410.2_Missense_Mutation_p.I109V|DHRS7_ENST00000553986.1_5'UTR|DHRS7_ENST00000557185.1_Missense_Mutation_p.I159V|PCNXL4_ENST00000406949.1_Intron|PCNXL4_ENST00000553898.1_Intron			Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7	159							binding|oxidoreductase activity			endometrium(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(108;0.121)		TTAAGCTCTATTAGCTTTCTG	0.423000													56	167					0	0	0.323286	0	0
MAP3K14	9020	broad.mit.edu	37	17	43350986	43350986	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:43350986C>A	ENST00000344686.2	-	0	1658							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TGCCAGGCCGCCCCGGGGAGG	0.622000													14	8					5.01169e-05	5.30277e-05	0.160694	1	0
RANBP17	64901	broad.mit.edu	37	5	170668068	170668068	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:170668068G>T	ENST00000523189.1	+	23	2723	c.2559G>T	c.(2557-2559)ttG>ttT	p.L853F	RANBP17_ENST00000521759.1_3'UTR	NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	853					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTTCAAGTTGTATGGGGACA	0.438000			T	TRD@	ALL								127	184					1.12488e-73	2.00909e-73	0.323286	1	0
CNTN3	5067	broad.mit.edu	37	3	74350660	74350660	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:74350660C>G	ENST00000263665.6	-	15	2011	c.1984G>C	c.(1984-1986)Gta>Cta	p.V662L		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	662	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		AACTCAACTACAGTGGCTGTG	0.428000													54	40					0	0	0.323286	0	0
BMP5	653	broad.mit.edu	37	6	55739649	55739649	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:55739649T>C	ENST00000370830.3	-	1	713	c.15A>G	c.(13-15)gtA>gtG	p.V5V	BMP5_ENST00000446683.2_Silent_p.V5V	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	5					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TAAGTAAAAATACAGTCAGAT	0.373000													120	280					0	0	0.323286	0	0
NEGR1	257194	broad.mit.edu	37	1	72241943	72241943	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:72241943G>T	ENST00000357731.4	-	3	686	c.447C>A	c.(445-447)acC>acA	p.T149T	NEGR1_ENST00000467479.1_5'UTR|NEGR1_ENST00000434200.1_Silent_p.T147T|NEGR1_ENST00000306821.3_Silent_p.T21T	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	149	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		CTTCATTGACGGTCATATCAT	0.388000													8	35					0.0477658	0.0484859	0.307466	1	0
TBL3	10607	broad.mit.edu	37	16	2026110	2026110	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:2026110G>A	ENST00000568546.1	+	12	1311	c.1183G>A	c.(1183-1185)Gcc>Acc	p.A395T		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	395					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						TGCCAGCTGTGCCAAGGTGAG	0.627000													3	8					0	0	0.150653	0	0
OR1A1	8383	broad.mit.edu	37	17	3119443	3119443	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:3119443T>G	ENST00000304094.1	+	1	529	c.529T>G	c.(529-531)Ttc>Gtc	p.F177V		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						AGTGGCCAACTTCTACTGTGA	0.493000													22	166					0	0	0.249174	0	0
DISC1	27185	broad.mit.edu	37	1	231829629	231829629	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:231829629G>T	ENST00000439617.2	+	2	178	c.125G>T	c.(124-126)aGg>aTg	p.R42M	DISC1_ENST00000602873.1_Intron|DISC1_ENST00000535983.1_Missense_Mutation_p.R42M|DISC1_ENST00000366633.3_Missense_Mutation_p.R42M|TRAX_ENST00000602962.1_3'UTR|DISC1_ENST00000366636.4_Missense_Mutation_p.R42M|DISC1_ENST00000539444.1_Missense_Mutation_p.R42M|DISC1_ENST00000366637.3_5'UTR|DISC1_ENST00000317586.4_Missense_Mutation_p.R42M|DISC1_ENST00000602281.1_Missense_Mutation_p.R42M|DISC1_ENST00000537876.1_Missense_Mutation_p.R42M	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	42	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				CTGGCACGGAGGCCGGGCTAC	0.602000													57	19					3.36121e-32	5.13803e-32	0.323286	1	0
KRT38	8687	broad.mit.edu	37	17	39597007	39597007	+	Missense_Mutation	SNP	C	C	A	rs113218990		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39597007C>A	ENST00000246646.3	-	1	166	c.167G>T	c.(166-168)cGt>cTt	p.R56L		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	56	Head.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				GGACCCCACACGGACTCGGTT	0.632000													25	44					9.39395e-14	1.1472e-13	0.116897	1	0
CYP4F24P	388514	broad.mit.edu	37	19	15882930	15882930	+	RNA	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:15882930C>G	ENST00000587443.2	-	0	747					NR_033864.1																						CATGTCCAGACGACTGCTGCC	0.567000													29	25					0	0	0.144211	0	0
KIRREL2	84063	broad.mit.edu	37	19	36353436	36353436	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:36353436G>T	ENST00000360202.5	+	12	1750	c.1552G>T	c.(1552-1554)Gcc>Tcc	p.A518S	KIRREL2_ENST00000347900.6_Missense_Mutation_p.A468S|KIRREL2_ENST00000586102.2_Missense_Mutation_p.A498S|KIRREL2_ENST00000262625.7_Missense_Mutation_p.A518S|NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000592409.1_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	518					cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGTGGCCGCTGCCACCACAAC	0.672000													57	60					1.8615e-32	2.85399e-32	0.323286	1	0
PTER	9317	broad.mit.edu	37	10	16528617	16528617	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:16528617G>T	ENST00000378000.1	+	4	944		c.e4+1		PTER_ENST00000423462.2_Splice_Site|PTER_ENST00000485788.1_3'UTR|PTER_ENST00000535784.2_Splice_Site|PTER_ENST00000298942.3_Splice_Site	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related						catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding	p.?(1)		endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						ACCTGGATAGGTAAGTAGGCT	0.418000													101	137					1.87388e-53	3.20807e-53	0.323286	1	0
COL9A1	1297	broad.mit.edu	37	6	71004046	71004046	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:71004046A>T	ENST00000357250.6	-	5	678	c.520T>A	c.(520-522)Tcc>Acc	p.S174T	COL9A1_ENST00000370496.3_Missense_Mutation_p.S174T	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	174	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						TCAAACAAGGAGGACAAATTC	0.408000													73	136					0	0	0.323286	0	0
CENPT	80152	broad.mit.edu	37	16	67862626	67862626	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:67862626A>G	ENST00000562787.1	-	14	1949	c.1401T>C	c.(1399-1401)ttT>ttC	p.F467F	CENPT_ENST00000440851.2_Silent_p.F467F|CENPT_ENST00000564817.1_Silent_p.F412F|CENPT_ENST00000219172.3_Silent_p.F467F	NM_025082.3	NP_079358.3	Q96BT3	CENPT_HUMAN	centromere protein T	467					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding			NS(1)|breast(2)|lung(6)|urinary_tract(1)	10		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CATAGAAGCTAAAGAGTTTCA	0.607000													9	314					0	0	0.058154	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25251549	25251549	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:25251549T>A	ENST00000328086.7	-	7	3295	c.2492A>T	c.(2491-2493)tAc>tTc	p.Y831F		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	831					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		TCCGCATCTGTAGGGTTTCTC	0.443000													161	18					0	0	0.323286	0	0
LRRK1	79705	broad.mit.edu	37	15	101598268	101598268	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:101598268G>T	ENST00000284395.5	+	30	4992	c.4592G>T	c.(4591-4593)tGt>tTt	p.C1531F	LRRK1_ENST00000388948.3_Missense_Mutation_p.C1534F|RP11-505E24.2_ENST00000559857.1_RNA			Q38SD2	LRRK1_HUMAN	leucine-rich repeat kinase 1	1534					small GTPase mediated signal transduction	mitochondrion	ATP binding|GTP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(25)|ovary(4)|prostate(1)|skin(1)	72	Melanoma(26;0.00505)|Lung NSC(78;0.00793)|all_lung(78;0.0094)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			GAACTGTGCTGTGGGAAGCAG	0.577000													71	44					4.49761e-31	6.79138e-31	0.323286	1	0
GAS2L2	246176	broad.mit.edu	37	17	34072633	34072633	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:34072633C>A	ENST00000254466.6	-	6	1910	c.1883G>T	c.(1882-1884)gGg>gTg	p.G628V	GAS2L2_ENST00000587565.1_Missense_Mutation_p.G612V	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	628					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGGGATGACCCCAGACCTTGT	0.577000													38	72					2.35958e-20	3.17034e-20	0.279185	1	0
FBXL18	80028	broad.mit.edu	37	7	5540452	5540452	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:5540452G>A	ENST00000382368.3	-	3	1571	c.1448C>T	c.(1447-1449)cCc>cTc	p.P483L	FBXL18_ENST00000453700.3_Missense_Mutation_p.P483L	NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	483									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		TTCCAGGAAGGGCAGGTTCTT	0.657000													4	7					0	0	0.150653	0	0
PTPRS	5802	broad.mit.edu	37	19	5239041	5239041	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:5239041C>T	ENST00000372412.4	-	13	1974	c.1741G>A	c.(1741-1743)Gtg>Atg	p.V581M	PTPRS_ENST00000348075.2_Missense_Mutation_p.V567M|PTPRS_ENST00000587303.1_Missense_Mutation_p.V580M|PTPRS_ENST00000357368.4_Missense_Mutation_p.V580M|PTPRS_ENST00000353284.2_Missense_Mutation_p.V567M|PTPRS_ENST00000588012.1_Missense_Mutation_p.V567M|PTPRS_ENST00000592099.1_Missense_Mutation_p.V567M|PTPRS_ENST00000262963.6_Missense_Mutation_p.V576M|PTPRS_ENST00000588552.1_5'UTR			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	580	Fibronectin type-III 3.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		TCCTCCACCACGTAGGAAGTC	0.672000													16	55					0	0	0.204396	0	0
ZNF17	7565	broad.mit.edu	37	19	57929296	57929296	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:57929296A>G	ENST00000307658.7	+	3	301	c.38A>G	c.(37-39)gAg>gGg	p.E13G	ZNF17_ENST00000595206.1_Intron|AC003002.6_ENST00000596400.1_Missense_Mutation_p.E23G|AC004076.7_ENST00000597410.1_Intron|ZNF17_ENST00000601808.1_Missense_Mutation_p.E11G			P17021	ZNF17_HUMAN	zinc finger protein 17	11	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		ATGGTTTTTGAGGACGTGGCC	0.393000													288	206					0	0	0.323286	0	0
TRIM9	114088	broad.mit.edu	37	14	51561429	51561429	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:51561429C>A	ENST00000298355.3	-	1	1350	c.229G>T	c.(229-231)Ggc>Tgc	p.G77C	TRIM9_ENST00000338969.5_Missense_Mutation_p.G77C|TRIM9_ENST00000360392.4_Missense_Mutation_p.G77C	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	77					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					GAGCCATAGCCGCTGTCCGCC	0.677000													11	9					2.48551e-13	3.01158e-13	0.160694	1	0
BRE	9577	broad.mit.edu	37	2	28467721	28467721	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:28467721T>G	ENST00000344773.2	+	10	1064	c.926T>G	c.(925-927)cTt>cGt	p.L309R	BRE_ENST00000342045.2_Missense_Mutation_p.L309R|BRE_ENST00000379624.1_Missense_Mutation_p.L309R|BRE_ENST00000379632.2_Missense_Mutation_p.L309R|BRE_ENST00000361704.2_Missense_Mutation_p.L309R	NM_004899.4	NP_004890.2	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A modulator)	309	UEV-like 2.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(2)	23	Acute lymphoblastic leukemia(172;0.155)					TTTTGTTTTCTTGTACACAGT	0.363000													38	43					0	0	0.235728	0	0
PTCRA	171558	broad.mit.edu	37	6	42883813	42883813	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:42883813C>A	ENST00000304672.1	+	1	87	c.6C>A	c.(4-6)gcC>gcA	p.A2A	PTCRA_ENST00000441198.1_Silent_p.A2A|PTCRA_ENST00000446507.1_Silent_p.A2A	NM_001243168.1|NM_138296.2	NP_001230097.1|NP_612153.2	Q6ISU1	PTCRA_HUMAN	pre T-cell antigen receptor alpha	2						integral to membrane	receptor activity	p.A2A(1)		large_intestine(2)|lung(4)|ovary(2)	8	Colorectal(47;0.196)		all cancers(41;0.000731)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			GGGCCATGGCCGGTACATGGC	0.642000													11	30					1.3612e-06	1.47349e-06	0.132662	1	0
DDX21	9188	broad.mit.edu	37	10	70726924	70726924	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:70726924A>T	ENST00000354185.4	+	6	1153	c.1055A>T	c.(1054-1056)cAa>cTa	p.Q352L		NM_001256910.1|NM_004728.3	NP_001243839.1|NP_004719.2	Q9NR30	DDX21_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 21	352	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(6)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	20						TTTGCTGATCAAGTGGAAGAG	0.408000													36	6					0	0	0.203993	0	0
PCDHGA12	26025	broad.mit.edu	37	5	140811613	140811613	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140811613C>T	ENST00000252085.3	+	1	1429	c.1287C>T	c.(1285-1287)acC>acT	p.T429T	PCDHGA11_ENST00000518882.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGGGGAACCCCGCCCCTAT	0.517000													20	25					0	0	0.324025	0	0
CASS4	57091	broad.mit.edu	37	20	55027392	55027392	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:55027392G>T	ENST00000371336.3	+	5	1361	c.1160G>T	c.(1159-1161)cGg>cTg	p.R387L	CASS4_ENST00000360314.3_Missense_Mutation_p.R387L|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	387	Ser-rich.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						TTCTCCAGACGGACAACTTCC	0.537000													17	60					5.26018e-13	6.34623e-13	0.234183	1	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77510163	77510163	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:77510163G>T	ENST00000477717.1	+	3	771	c.536G>T	c.(535-537)cGg>cTg	p.R179L		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	179					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						TACATGCGGCGGGACGGCAAG	0.602000													123	73					1.23122e-68	2.18641e-68	0.323286	1	0
WNT9B	7484	broad.mit.edu	37	17	44949909	44949909	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:44949909C>T	ENST00000393461.2	+	2	157	c.104C>T	c.(103-105)cCc>cTc	p.P35L	WNT9B_ENST00000290015.2_Missense_Mutation_p.P35L			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	35					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GTCCTGACGCCCTTCCCAGGA	0.667000													169	90					0	0	0.323286	0	0
OR2M4	26245	broad.mit.edu	37	1	248402462	248402462	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248402462C>A	ENST00000306687.1	+	1	232	c.232C>A	c.(232-234)Cta>Ata	p.L78I		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	78					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CTGCACCACTCTACCCAAGAT	0.478000													270	123					3.05604e-136	5.65049e-136	0.323286	1	0
SLC26A10	65012	broad.mit.edu	37	12	58018915	58018915	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:58018915A>T	ENST00000320442.4	+	11	1665	c.1354A>T	c.(1354-1356)Aag>Tag	p.K452*	SLC26A10_ENST00000379218.2_3'UTR|SLC26A10_ENST00000490243.1_3'UTR	NM_133489.2	NP_597996.2	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	452	STAS.					integral to membrane	antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)	19	Melanoma(17;0.122)					GGAGACTTCAAAGCCAGATGG	0.522000													172	317					0	0	0.323286	0	0
SKP2	6502	broad.mit.edu	37	5	36153042	36153042	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:36153042G>T	ENST00000274255.6	+	2	374	c.178G>T	c.(178-180)Ggc>Tgc	p.G60C	SKP2_ENST00000508514.1_Missense_Mutation_p.G60C|SKP2_ENST00000274254.5_Missense_Mutation_p.G60C|SKP2_ENST00000546211.1_5'UTR	NM_005983.3	NP_005974.2	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	60					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			breast(1)|central_nervous_system(2)|ovary(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CTCAAACCTGGGCCACCCGGA	0.567000													47	63					1.07234e-20	1.44771e-20	0.323286	1	0
NLGN3	54413	broad.mit.edu	37	X	70389250	70389250	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:70389250G>A	ENST00000374051.3	+	7	2112	c.1790G>A	c.(1789-1791)cGg>cAg	p.R597Q	NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000536169.1_Missense_Mutation_p.R577Q|NLGN3_ENST00000358741.3_Missense_Mutation_p.R617Q	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	617					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity	p.R597Q(1)|p.R617Q(1)		biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					GATCATTACCGGGCCACTAAG	0.547000													20	15					0	0	0.249174	0	0
FNBP4	23360	broad.mit.edu	37	11	47774472	47774472	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:47774472T>A	ENST00000263773.5	-	4	645	c.633A>T	c.(631-633)gcA>gcT	p.A211A	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	211										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						GTTTACCTCCTGCCAGTGAAC	0.368000													86	49					0	0	0.323286	0	0
SLC16A10	117247	broad.mit.edu	37	6	111543326	111543326	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:111543326A>T	ENST00000368850.3	+	5	980	c.494A>T	c.(493-495)gAg>gTg	p.E165V	SLC16A10_ENST00000368851.5_Missense_Mutation_p.E479V			Q8TF71	MOT10_HUMAN	solute carrier family 16 (aromatic amino acid transporter), member 10	479					aromatic amino acid transport|cellular nitrogen compound metabolic process|ion transport	basolateral plasma membrane|integral to membrane	amino acid transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)	12		all_cancers(87;0.00172)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.0313)|Colorectal(196;0.0466)		OV - Ovarian serous cystadenocarcinoma(136;0.0703)|Epithelial(106;0.12)|all cancers(137;0.132)		AAGCAAAGAGAGATCAGTAAA	0.438000													61	159					0	0	0.323286	0	0
EPB41L3	23136	broad.mit.edu	37	18	5397212	5397212	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:5397212C>A	ENST00000341928.2	-	18	3026	c.2686G>T	c.(2686-2688)Gcc>Tcc	p.A896S	EPB41L3_ENST00000542652.2_5'UTR|EPB41L3_ENST00000542146.1_Missense_Mutation_p.A201S|EPB41L3_ENST00000427684.2_Missense_Mutation_p.A193S|EPB41L3_ENST00000400111.3_Missense_Mutation_p.A674S|EPB41L3_ENST00000342933.3_Missense_Mutation_p.A896S|EPB41L3_ENST00000544123.1_Missense_Mutation_p.A727S|EPB41L3_ENST00000540638.2_Missense_Mutation_p.A674S	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	896	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity	p.A896S(1)		breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						TCCGTCAAGGCAGAGCCCTCT	0.602000													76	15					1.72036e-36	2.71696e-36	0.323286	1	0
AGO1	26523	broad.mit.edu	37	1	36358858	36358858	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:36358858T>C	ENST00000373204.4	+	4	704	c.491T>C	c.(490-492)aTg>aCg	p.M164T	AGO1_ENST00000373206.1_Missense_Mutation_p.M89T	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		GATGTGGCCATGAGGCACCTG	0.562000													20	202					0	0	0.116897	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43856708	43856708	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:43856708C>A	ENST00000389420.3	-	11	1603	c.1604G>T	c.(1603-1605)gGt>gTt	p.G535V	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.G535V	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	535	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CATTCCAGGACCGCAGTCTGT	0.443000													5	20					0.000602214	0.000625229	0.184627	1	0
CASK	8573	broad.mit.edu	37	X	41604855	41604855	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:41604855C>A	ENST00000318588.9	-	4	324		c.e4-1		CASK_ENST00000378158.1_Splice_Site|CASK_ENST00000378163.1_Splice_Site|CASK_ENST00000421587.2_Splice_Site|CASK_ENST00000378154.1_Splice_Site|CASK_ENST00000442742.2_Splice_Site|CASK_ENST00000378166.4_Splice_Site|CASK_ENST00000361962.4_Splice_Site			O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein kinase (MAGUK family)						cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|ovary(3)|prostate(1)|stomach(1)	32						TCCATCCATACTGTAAAAAAA	0.353000													9	16					9.05144e-12	1.07075e-11	0.105934	1	0
BCAR3	8412	broad.mit.edu	37	1	94140199	94140199	+	Silent	SNP	C	C	T	rs112584760	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:94140199C>T	ENST00000370244.1	-	4	576	c.288G>A	c.(286-288)caG>caA	p.Q96Q	BCAR3_ENST00000260502.6_Silent_p.Q96Q|BCAR3_ENST00000370243.1_Silent_p.Q96Q	NM_001261408.1	NP_001248337.1	O75815	BCAR3_HUMAN	breast cancer anti-estrogen resistance 3	96					response to drug|small GTPase mediated signal transduction	intracellular	guanyl-nucleotide exchange factor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)	25		all_lung(203;0.00145)|Lung NSC(277;0.00662)		all cancers(265;0.0126)|GBM - Glioblastoma multiforme(16;0.0467)|Epithelial(280;0.166)		CGTGCCGGTCCTGCCATGGGC	0.517000													25	16					0	0	0.116897	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460148	107460148	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:107460148G>A	ENST00000409382.3	-	2	896	c.286C>T	c.(286-288)Ctg>Ttg	p.L96L	ST6GAL2_ENST00000361686.4_Silent_p.L96L|ST6GAL2_ENST00000409087.3_Silent_p.L96L	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	96					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CATTTCTGCAGGTCTCCAGGC	0.617000													59	43					0	0	0.323286	0	0
POM121L2	94026	broad.mit.edu	37	6	27277865	27277865	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:27277865A>T	ENST00000444565.1	-	1	2084	c.2085T>A	c.(2083-2085)acT>acA	p.T695T	POM121L2_ENST00000377451.2_Silent_p.T631T	NM_033482.3	NP_258443.2	C9J1I7	C9J1I7_HUMAN	POM121 transmembrane nucleoporin-like 2	695										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|skin(1)	7						CTGTATGCACAGTAGGAATTG	0.532000													4	13					0	0	0.150653	0	0
PRSS58	136541	broad.mit.edu	37	7	141952058	141952058	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:141952058C>A	ENST00000552471.1	-	5	1028	c.709G>T	c.(709-711)Gta>Tta	p.V237L	PRSS58_ENST00000547058.2_Missense_Mutation_p.V237L			Q8IYP2	PRS58_HUMAN	protease, serine, 58	237	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						TTTTGGATTACATTTTCAATC	0.388000													46	37					4.86159e-25	6.91293e-25	0.323286	1	0
MUTYH	4595	broad.mit.edu	37	1	45796910	45796910	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:45796910G>A	ENST00000450313.1	-	14	1635	c.1420C>T	c.(1420-1422)Cgc>Tgc	p.R474C	MUTYH_ENST00000354383.6_Missense_Mutation_p.R447C|MUTYH_ENST00000456914.2_Missense_Mutation_p.R446C|MUTYH_ENST00000372098.3_Missense_Mutation_p.R471C|MUTYH_ENST00000372100.5_Missense_Mutation_p.R457C|MUTYH_ENST00000372104.1_Missense_Mutation_p.R446C|MUTYH_ENST00000488731.2_Missense_Mutation_p.R141C|MUTYH_ENST00000372110.3_Missense_Mutation_p.R461C|MUTYH_ENST00000355498.2_Missense_Mutation_p.R446C|MUTYH_ENST00000531105.1_Intron|MUTYH_ENST00000372115.3_Missense_Mutation_p.R460C|MUTYH_ENST00000529984.1_Missense_Mutation_p.R141C|MUTYH_ENST00000528332.2_Missense_Mutation_p.R155C|MUTYH_ENST00000448481.1_Missense_Mutation_p.R457C	NM_001128425.1|NM_012222.2	NP_001121897.1|NP_036354.1	Q9UIF7	MUTYH_HUMAN	mutY homolog	471	Nudix hydrolase.				depurination|mismatch repair	nucleoplasm	4 iron, 4 sulfur cluster binding|DNA N-glycosylase activity|endonuclease activity|metal ion binding|MutSalpha complex binding	p.R471C(1)		NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					GTCAGCCAGCGAGCACCTGGT	0.522000			Mis			colorectal		Base excision repair (BER), DNA glycosylases	MUTYH-associated polyposis				10	163					0	0	0.119110	0	0
AGAP1	116987	broad.mit.edu	37	2	236659003	236659003	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:236659003A>G	ENST00000409538.1	+	6	1835	c.1339A>G	c.(1339-1341)Ata>Gta	p.I447V	AGAP1_ENST00000428334.2_Missense_Mutation_p.I21V|AGAP1_ENST00000409457.1_Missense_Mutation_p.I182V|AGAP1_ENST00000336665.5_Missense_Mutation_p.I182V|AGAP1_ENST00000304032.7_Missense_Mutation_p.I182V			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	182	PH.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						TCCAGATGCCATAAGTTCTGC	0.507000													16	108					0	0	0.234183	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68703791	68703791	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:68703791C>A	ENST00000255078.3	+	13	1954	c.1843C>A	c.(1843-1845)Cgt>Agt	p.R615S	IGHMBP2_ENST00000541229.1_3'UTR	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	615					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding	p.R615S(1)|p.R615C(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			CTGTGACTCCCGTACTGTCAA	0.532000													54	136					7.92265e-33	1.21829e-32	0.323286	1	0
NIPBL	25836	broad.mit.edu	37	5	36962301	36962301	+	Missense_Mutation	SNP	G	G	T	rs142923613	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:36962301G>T	ENST00000282516.8	+	6	1034	c.535G>T	c.(535-537)Gcc>Tcc	p.A179S	NIPBL_ENST00000504430.1_3'UTR|NIPBL_ENST00000448238.2_Missense_Mutation_p.A179S	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	179					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			TAGTCCATACGCCCCACAAAG	0.453000													175	526					3.04991e-78	5.46302e-78	0.323286	1	0
COL3A1	1281	broad.mit.edu	37	2	189856422	189856422	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:189856422G>T	ENST00000304636.3	+	13	1095	c.925G>T	c.(925-927)Gga>Tga	p.G309*	COL3A1_ENST00000317840.5_Nonsense_Mutation_p.G309*	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	309	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.A304_G309delAPGERG(1)		NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TGGTGAGCGAGGACGGCCAGG	0.463000													76	91					2.08528e-44	3.43517e-44	0.323286	1	0
PTCHD4	442213	broad.mit.edu	37	6	47846647	47846647	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:47846647G>T	ENST00000339488.4	-	3	1966	c.1933C>A	c.(1933-1935)Ccc>Acc	p.P645T		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	645						integral to membrane	hedgehog receptor activity										ACAAAGGAGGGGTTGAACACG	0.478000													73	217					4.92877e-23	6.87275e-23	0.323286	1	0
DNAH12	201625	broad.mit.edu	37	3	57356409	57356409	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:57356409C>G	ENST00000351747.2	-	50	8062	c.7882G>C	c.(7882-7884)Gat>Cat	p.D2628H	DNAH12_ENST00000344804.4_Missense_Mutation_p.D261H	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	2628	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						AACTCAGGATCAGAAACTGGA	0.378000													14	5					0	0	0.132662	0	0
GOLGA5	9950	broad.mit.edu	37	14	93299644	93299644	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:93299644A>G	ENST00000163416.2	+	10	2153	c.1897A>G	c.(1897-1899)Agt>Ggt	p.S633G	GOLGA5_ENST00000355976.2_Missense_Mutation_p.S633G	NM_005113.2	NP_005104.2	Q8TBA6	GOGA5_HUMAN	golgin A5	633					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		CTCTGGAAGTAGTAGTAATGG	0.423000			T	RET	papillary thyroid								143	269					0	0	0.323286	0	0
PTGIR	5739	broad.mit.edu	37	19	47127354	47127354	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:47127354C>T	ENST00000291294.2	-	2	262	c.129G>A	c.(127-129)ccG>ccA	p.P43P	PTGIR_ENST00000594275.1_Intron|PTGIR_ENST00000598865.1_Intron|PTGIR_ENST00000597185.1_Intron|PTGIR_ENST00000596260.1_Silent_p.P43P	NM_000960.3	NP_000951.1	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	43					cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	13		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	AGGGGCGCGCCGGTCGCCGTG	0.741000													4	2					0	0	0.184627	0	0
DMRT2	10655	broad.mit.edu	37	9	1056572	1056572	+	Missense_Mutation	SNP	G	G	A	rs142906421		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:1056572G>A	ENST00000382251.3	+	5	1314	c.985G>A	c.(985-987)Gcc>Acc	p.A329T	DMRT2_ENST00000302441.6_Missense_Mutation_p.A329T|DMRT2_ENST00000259622.6_3'UTR|DMRT2_ENST00000358146.2_Missense_Mutation_p.A329T|DMRT2_ENST00000382255.3_3'UTR			Q9Y5R5	DMRT2_HUMAN	doublesex and mab-3 related transcription factor 2	329				A -> G (in Ref. 2; AAF86292/AAF86294).	male gonad development|sex determination	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(1)|prostate(2)	4		all_lung(10;1.49e-09)|Lung NSC(10;1.86e-09)		Lung(218;0.0195)|GBM - Glioblastoma multiforme(50;0.0388)		TGTCAGCGTGGCCACAACTTA	0.448000													133	240					0	0	0.323286	0	0
PROL1	58503	broad.mit.edu	37	4	71275470	71275470	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:71275470C>T	ENST00000399575.2	+	3	599	c.425C>T	c.(424-426)cCc>cTc	p.P142L	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	142	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				AACCCTGAGCCCCAAATAAAC	0.438000													98	53					0	0	0.323286	0	0
SLC25A21	89874	broad.mit.edu	37	14	37641526	37641526	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:37641526C>T	ENST00000331299.5	-	1	545	c.30G>A	c.(28-30)gtG>gtA	p.V10V	SLC25A21-AS1_ENST00000556667.1_5'UTR|SLC25A21_ENST00000557611.1_5'UTR|SLC25A21_ENST00000555449.1_Silent_p.V10V	NM_030631.3	NP_085134.1	Q9BQT8	ODC_HUMAN	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21	10					lysine catabolic process	integral to membrane|mitochondrial inner membrane	alpha-ketoglutarate transmembrane transporter activity|binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|pancreas(1)|prostate(1)|skin(1)	9	Esophageal squamous(585;0.164)|Breast(36;0.179)|Hepatocellular(127;0.213)		Lung(8;2.16e-08)|LUAD - Lung adenocarcinoma(9;2.16e-07)|Epithelial(34;0.0112)|all cancers(34;0.0274)|LUSC - Lung squamous cell carcinoma(13;0.149)	GBM - Glioblastoma multiforme(112;0.00204)		AAGCCTCGCGCACTAAGCTGA	0.652000													9	14					0	0	0.080935	0	0
HERC2	8924	broad.mit.edu	37	15	28520107	28520107	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:28520107C>A	ENST00000261609.7	-	6	695	c.587G>T	c.(586-588)gGa>gTa	p.G196V		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	196					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGCTCGGGATCCCACTCTGGC	0.607000													20	26					2.21704e-12	2.64592e-12	0.264190	1	0
DNAH7	56171	broad.mit.edu	37	2	196699047	196699047	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:196699047T>G	ENST00000312428.6	-	48	9083	c.8983A>C	c.(8983-8985)Agt>Cgt	p.S2995R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2995	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TTAGCCTGACTTTGAGGATCT	0.388000													38	79					0	0	0.312237	0	0
MYB	4602	broad.mit.edu	37	6	135520132	135520132	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:135520132T>A	ENST00000341911.5	+	11	1852	c.1653T>A	c.(1651-1653)acT>acA	p.T551T	MYB_ENST00000528774.1_Silent_p.T548T|MYB_ENST00000442647.2_Silent_p.T427T|MYB_ENST00000531845.1_3'UTR|MYB_ENST00000367814.4_Silent_p.T430T|MYB_ENST00000534044.1_Silent_p.T430T|MYB_ENST00000527615.1_Silent_p.T430T|MYB_ENST00000534121.1_Silent_p.T535T|MYB_ENST00000533624.1_Silent_p.T395T|MYB_ENST00000316528.8_Silent_p.T430T|MYB_ENST00000525369.1_Silent_p.T345T	NM_001130173.1|NM_001161656.1|NM_001161658.1	NP_001123645.1|NP_001155128.1|NP_001155130.1	P10242	MYB_HUMAN	v-myb avian myeloblastosis viral oncogene homolog	487					blood coagulation|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone H3-K4 methylation|positive regulation of histone H3-K9 methylation|positive regulation of T-helper cell differentiation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear matrix	DNA binding|protein binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	28	all_epithelial(2;0.109)|Breast(56;0.158)|Colorectal(23;0.221)	Lung NSC(302;3.08e-05)|Ovarian(999;0.208)		OV - Ovarian serous cystadenocarcinoma(155;0.0079)|GBM - Glioblastoma multiforme(68;0.0117)		ACAAATTGACTGTTACAACAC	0.353000			T	NFIB	adenoid cystic carcinoma								53	26					0	0	0.323286	0	0
ZP1	22917	broad.mit.edu	37	11	60635067	60635067	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:60635067C>G	ENST00000278853.5	+	1	33	c.33C>G	c.(31-33)taC>taG	p.Y11*		NM_207341.2	NP_997224.2	P60852	ZP1_HUMAN	zona pellucida glycoprotein 1 (sperm receptor)	11					single fertilization	integral to membrane|plasma membrane|proteinaceous extracellular matrix				breast(3)|endometrium(2)|large_intestine(8)|lung(8)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						CCTGGGGTTACCCTGTGGCCC	0.672000													6	16					0	0	0.307466	0	0
SLC5A5	6528	broad.mit.edu	37	19	17988772	17988772	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:17988772G>T	ENST00000222248.3	+	7	1186		c.e7-1			NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5						cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						TCTTCCCCCAGGGCCCTGCTC	0.612000													11	35					0.00136819	0.00141243	0.093190	1	0
TTN	7273	broad.mit.edu	37	2	179611074	179611074	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179611074T>A	ENST00000360870.5	-	46	16275	c.16053A>T	c.(16051-16053)ccA>ccT	p.P5351P	TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8864	Ig-like 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAAATTAAATGGAAGAACAT	0.338000													30	94					0	0	0.153744	0	0
RPIA	22934	broad.mit.edu	37	2	89049591	89049591	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:89049591G>A	ENST00000283646.4	+	9	987	c.932G>A	c.(931-933)tGt>tAt	p.C311Y		NM_144563.2	NP_653164.2	P49247	RPIA_HUMAN	ribose 5-phosphate isomerase A	311					pentose-phosphate shunt, non-oxidative branch	cytosol	ribose-5-phosphate isomerase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18		Acute lymphoblastic leukemia(2;0.000456)|all_hematologic(2;0.00287)				AAGCCTTTCTGTTGACCCTGC	0.537000													25	46					0	0	0.116897	0	0
SASH1	23328	broad.mit.edu	37	6	148795358	148795358	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:148795358G>T	ENST00000367467.3	+	7	1102	c.627_splice	c.e7+1	p.R209_splice		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	209							protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CACTTGCTAGGGTAAGCATGC	0.423000													13	28					4.36969e-10	4.98818e-10	0.105934	1	0
SLC27A6	28965	broad.mit.edu	37	5	128320926	128320926	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:128320926A>C	ENST00000262462.4	+	2	1592	c.582A>C	c.(580-582)aaA>aaC	p.K194N	SLC27A6_ENST00000506176.1_Missense_Mutation_p.K194N|SLC27A6_ENST00000395266.1_Missense_Mutation_p.K194N			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	194					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TTTCACTCAAAGAAAAACTGA	0.438000													9	55					0	0	0.058154	0	0
SORL1	6653	broad.mit.edu	37	11	121491932	121491932	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:121491932A>G	ENST00000260197.7	+	44	6178	c.6049A>G	c.(6049-6051)Ata>Gta	p.I2017V	SORL1_ENST00000532694.1_Missense_Mutation_p.I863V|SORL1_ENST00000525532.1_Missense_Mutation_p.I961V|SORL1_ENST00000527934.1_Missense_Mutation_p.I632V|SORL1_ENST00000534286.1_Missense_Mutation_p.I927V	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2017	Fibronectin type-III 5.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		AGATTCCAGCATAAAAATTAC	0.488000													21	72					0	0	0.249174	0	0
SLC4A3	6508	broad.mit.edu	37	2	220505152	220505152	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220505152G>T	ENST00000358055.3	+	21	3790	c.3277_splice	c.e21-1	p.G1093_splice	SLC4A3_ENST00000273063.6_Splice_Site_p.G1120_splice|SLC4A3_ENST00000317151.3_Splice_Site_p.G1093_splice|SLC4A3_ENST00000373760.2_Splice_Site_p.G1093_splice|SLC4A3_ENST00000373762.3_Splice_Site_p.G1120_splice			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	1093	Membrane (anion exchange).				bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTCCTCCAGGCCTGTCCATC	0.612000													22	81					1.5548e-18	2.03431e-18	0.324025	1	0
SACS	26278	broad.mit.edu	37	13	23907231	23907231	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:23907231A>C	ENST00000382298.3	-	10	11372	c.10784T>G	c.(10783-10785)cTt>cGt	p.L3595R	SACS_ENST00000402364.1_Missense_Mutation_p.L2845R|SACS_ENST00000382292.3_Missense_Mutation_p.L3595R	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3595					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTGCTGAGAAAGTATGTATTT	0.328000													10	19					0	0	0.119110	0	0
ATP6V0A4	50617	broad.mit.edu	37	7	138453945	138453945	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:138453945T>A	ENST00000310018.2	-	4	451	c.169A>T	c.(169-171)Agg>Tgg	p.R57W	ATP6V0A4_ENST00000483139.1_5'UTR|ATP6V0A4_ENST00000353492.4_Missense_Mutation_p.R57W|ATP6V0A4_ENST00000393054.1_Missense_Mutation_p.R57W	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	57					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GATTCACACCTTCTGACTTCA	0.378000													42	101					0	0	0.290176	0	0
SNRNP48	154007	broad.mit.edu	37	6	7601747	7601747	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:7601747A>T	ENST00000342415.5	+	5	644	c.585A>T	c.(583-585)aaA>aaT	p.K195N		NM_152551.3	NP_689764.3	Q6IEG0	SNR48_HUMAN	small nuclear ribonucleoprotein 48kDa (U11/U12)	195					mRNA processing	cytoplasm|U12-type spliceosomal complex	metal ion binding			kidney(2)|lung(5)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	10						TGGCTGCCAAAATCAATCAAG	0.353000													33	106					0	0	0.290176	0	0
WSCD1	23302	broad.mit.edu	37	17	5993787	5993787	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:5993787T>C	ENST00000574946.1	+	4	1079	c.689T>C	c.(688-690)gTg>gCg	p.V230A	WSCD1_ENST00000574232.1_Missense_Mutation_p.V230A|WSCD1_ENST00000539421.1_Missense_Mutation_p.V230A|WSCD1_ENST00000317744.5_Missense_Mutation_p.V230A|WSCD1_ENST00000573634.1_Missense_Mutation_p.V114A			Q658N2	WSCD1_HUMAN	WSC domain containing 1	230	WSC 1.					integral to membrane	sulfotransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						CGGCTCTCCGTGTACCGTGTG	0.652000													13	15					0	0	0.105934	0	0
LSM14A	26065	broad.mit.edu	37	19	34706522	34706522	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:34706522G>T	ENST00000544216.3	+	6	814	c.737G>T	c.(736-738)aGg>aTg	p.R246M	LSM14A_ENST00000540746.2_Missense_Mutation_p.R205M|LSM14A_ENST00000433627.5_Missense_Mutation_p.R246M	NM_015578.2	NP_056393.2	Q8ND56	LS14A_HUMAN	LSM14A, SCD6 homolog A (S. cerevisiae)	246					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					AAAGTTTCAAGGCCAGAAAAT	0.358000													67	146					3.25985e-27	4.73535e-27	0.323286	1	0
KIAA1045	23349	broad.mit.edu	37	9	34971551	34971551	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:34971551C>A	ENST00000242315.3	+	2	338	c.256C>A	c.(256-258)Cgc>Agc	p.R86S	KIAA1045_ENST00000476115.2_Intron|KIAA1045_ENST00000544237.1_Missense_Mutation_p.R86S	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	86							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			CCGAGATGGGCGCGGCGTGGA	0.617000													145	134					5.82429e-73	1.03785e-72	0.323286	1	0
ZBP1	81030	broad.mit.edu	37	20	56191317	56191317	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:56191317A>T	ENST00000340462.4	-	2	522	c.242T>A	c.(241-243)cTg>cAg	p.L81Q	ZBP1_ENST00000343535.4_Missense_Mutation_p.L81Q|ZBP1_ENST00000371173.3_Missense_Mutation_p.L81Q|ZBP1_ENST00000395822.3_Intron|ZBP1_ENST00000538947.1_5'UTR|ZBP1_ENST00000541799.1_Missense_Mutation_p.L81Q			Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	81						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GGACAAGGCCAGCTCTGCAGG	0.607000													27	59					0	0	0.116897	0	0
ZFYVE9	9372	broad.mit.edu	37	1	52704428	52704428	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:52704428C>A	ENST00000287727.3	+	4	1511	c.1339C>A	c.(1339-1341)Cta>Ata	p.L447I	ZFYVE9_ENST00000361625.1_Missense_Mutation_p.L447I|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.L447I|ZFYVE9_ENST00000357206.2_Missense_Mutation_p.L447I	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	447					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						AGATGCAGGTCTAGATTTAAA	0.393000													43	105					1.57945e-13	1.92506e-13	0.301197	1	0
MORF4L2	9643	broad.mit.edu	37	X	102931491	102931491	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:102931491T>A	ENST00000423833.2	-	3	1690	c.465A>T	c.(463-465)gtA>gtT	p.V155V	MORF4L2_ENST00000360458.1_Silent_p.V155V|MORF4L2_ENST00000451301.1_Silent_p.V155V|MORF4L2_ENST00000433176.2_Silent_p.V155V|MORF4L2_ENST00000441076.2_Silent_p.V155V|MORF4L2_ENST00000422154.2_Silent_p.V155V|MORF4L2_ENST00000372620.1_Silent_p.V37V			Q15014	MO4L2_HUMAN	mortality factor 4 like 2	155					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)	13						GAATTGCATCTACATTTTTCT	0.398000													133	18					0	0	0.323286	0	0
GHRHR	2692	broad.mit.edu	37	7	31015438	31015438	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:31015438A>T	ENST00000409904.3	+	7	995	c.737A>T	c.(736-738)aAa>aTa	p.K246I	GHRHR_ENST00000409316.1_Missense_Mutation_p.E76D|GHRHR_ENST00000326139.2_Missense_Mutation_p.K310I|GHRHR_ENST00000461424.1_3'UTR			Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	310					activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			biliary_tract(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35					Sermorelin(DB00010)	CTGGTGAGGAAACTGGAGCCA	0.517000													37	41					0	0	0.268233	0	0
GABBR2	9568	broad.mit.edu	37	9	101056158	101056158	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:101056158G>C	ENST00000259455.2	-	18	3028	c.2569C>G	c.(2569-2571)Cac>Gac	p.H857D		NM_005458.7	NP_005449.5	O75899	GABR2_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 2	857					negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity		NOTCH1_ENST00000277541/GABBR2(2)	breast(4)|endometrium(4)|large_intestine(12)|lung(21)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	49		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	TGATCGAGGTGATTTTTTAAA	0.373000													61	8					0	0	0.323286	0	0
ACTRT1	139741	broad.mit.edu	37	X	127186093	127186093	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:127186093G>T	ENST00000371124.3	-	1	289	c.93C>A	c.(91-93)ccC>ccA	p.P31P		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	31						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						TGACATGGCGGGGTCCAATCT	0.448000													74	8					2.6465e-34	4.10838e-34	0.323286	1	0
DCAF8L2	347442	broad.mit.edu	37	X	27766465	27766465	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:27766465G>T	ENST00000451261.2	+	5	1852	c.1453G>T	c.(1453-1455)Gta>Tta	p.V485L		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						GAGTGAGTTTGTAGTGAGCGG	0.443000													17	33					1.5739e-10	1.81947e-10	0.146539	1	0
CPA5	93979	broad.mit.edu	37	7	130007797	130007797	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:130007797C>A	ENST00000485477.1	+	11	2218	c.1089C>A	c.(1087-1089)atC>atA	p.I363I	CPA5_ENST00000474905.1_Silent_p.I363I|CPA5_ENST00000466363.2_Silent_p.I363I|CPA5_ENST00000461828.1_Silent_p.I363I|CPA5_ENST00000431780.2_Intron|CPA5_ENST00000393213.3_Silent_p.I363I|CPA5_ENST00000355388.3_Silent_p.I363I			Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5	363					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(2)|breast(2)|endometrium(2)|large_intestine(7)|lung(4)|ovary(3)|pancreas(1)|skin(2)	23	Melanoma(18;0.0435)					TCCATGGGATCGAGTACATTT	0.602000													20	79					3.01185e-09	3.38573e-09	0.294199	1	0
OR6C1	390321	broad.mit.edu	37	12	55715252	55715252	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55715252T>A	ENST00000379668.2	+	1	907	c.869T>A	c.(868-870)cTa>cAa	p.L290Q		NM_001005182.1	NP_001005182.1	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C, member 1	290					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|liver(2)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	25						ATTTACAGCCTAAGAAATCAG	0.413000													70	164					0	0	0.323286	0	0
ZP4	57829	broad.mit.edu	37	1	238048069	238048069	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:238048069G>T	ENST00000366570.4	-	10	1548	c.1390_splice	c.e10+1	p.R464_splice	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	464	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGTTACTCACGACTGAGATCA	0.493000													11	39					2.61681e-11	3.07096e-11	0.119110	1	0
GABRB3	2562	broad.mit.edu	37	15	26866647	26866647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:26866647C>A	ENST00000541819.2	-	5	545	c.443G>T	c.(442-444)tGg>tTg	p.W148L	GABRB3_ENST00000545868.1_Missense_Mutation_p.W7L|GABRB3_ENST00000400188.3_Missense_Mutation_p.W21L|GABRB3_ENST00000299267.4_Missense_Mutation_p.W92L|GABRB3_ENST00000311550.5_Missense_Mutation_p.W92L			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	92					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTTATCTCTCCAATATTGTTG	0.443000													34	48					1.36615e-20	1.84195e-20	0.173368	1	0
HIVEP2	3097	broad.mit.edu	37	6	143091672	143091672	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:143091672C>A	ENST00000367603.2	-	5	4946	c.4204G>T	c.(4204-4206)Gag>Tag	p.E1402*	HIVEP2_ENST00000367604.1_Nonsense_Mutation_p.E1402*|HIVEP2_ENST00000012134.2_Nonsense_Mutation_p.E1402*	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1402					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GGGTACTTCTCCAAGCCCGCA	0.547000													38	31					1.04594e-18	1.37199e-18	0.235728	1	0
HAP1	9001	broad.mit.edu	37	17	39883692	39883692	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39883692C>A	ENST00000310778.5	-	9	1298	c.1289G>T	c.(1288-1290)gGt>gTt	p.G430V	JUP_ENST00000540235.1_Intron|HAP1_ENST00000393939.2_Intron|HAP1_ENST00000341193.5_Intron|HAP1_ENST00000347901.4_Intron			P54257	HAP1_HUMAN	huntingtin-associated protein 1	430	Glu-rich.|HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			CAGCTGGGAACCCACCCACAC	0.622000													13	27					3.41278e-10	3.90158e-10	0.160694	1	0
OR1C1	26188	broad.mit.edu	37	1	247920886	247920886	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247920886T>G	ENST00000408896.2	-	1	1096	c.823A>C	c.(823-825)Acc>Ccc	p.T275P		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TACATGATGGTTGACAGAGTG	0.498000													31	252					0	0	0.225048	0	0
ZNF730	100129543	broad.mit.edu	37	19	23329342	23329342	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:23329342A>C	ENST00000597761.2	+	4	1695	c.1496A>C	c.(1495-1497)aAg>aCg	p.K499T		NM_001277403.1	NP_001264332.1			zinc finger protein 730											endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						ACTAGGCATAAGACAATTCAT	0.338000													5	29					0	0	0.184627	0	0
SYNE1	23345	broad.mit.edu	37	6	152706953	152706953	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:152706953T>A	ENST00000367255.5	-	55	9109	c.8508A>T	c.(8506-8508)gaA>gaT	p.E2836D	SYNE1_ENST00000448038.1_Missense_Mutation_p.E2843D|SYNE1_ENST00000265368.4_Missense_Mutation_p.E2836D|SYNE1_ENST00000423061.1_Missense_Mutation_p.E2843D|SYNE1_ENST00000341594.5_Missense_Mutation_p.E2875D	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2836					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCACAATCTCTTCCACTTTCC	0.408000										HNSCC(10;0.0054)			15	209					0	0	0.189662	0	0
CES1	1066	broad.mit.edu	37	16	55862837	55862837	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:55862837C>G	ENST00000422046.2	-	2	380	c.99G>C	c.(97-99)gtG>gtC	p.V33V	CES1_ENST00000361503.4_Silent_p.V33V|CES1_ENST00000360526.3_Silent_p.V34V			P23141	EST1_HUMAN	carboxylesterase 1	33					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	ACTTCCCCAGCACTTTGCCAT	0.552000													17	67					0	0	0.175082	0	0
GTF2I	2969	broad.mit.edu	37	7	74113371	74113371	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:74113371G>C	ENST00000324896.4	+	4	708	c.319G>C	c.(319-321)Gta>Cta	p.V107L	AC083884.8_ENST00000450426.2_RNA|GTF2I_ENST00000416070.1_Missense_Mutation_p.V107L|GTF2I_ENST00000353920.4_Missense_Mutation_p.V107L|GTF2I_ENST00000443166.1_Missense_Mutation_p.V107L|GTF2I_ENST00000346152.4_Missense_Mutation_p.V107L	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	107					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						TGTAGATGCTGTAGAAATTGA	0.294000													21	19					0	0	0.309145	0	0
TAF7	6879	broad.mit.edu	37	5	140698996	140698996	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140698996C>A	ENST00000313368.5	-	1	1334	c.616G>T	c.(616-618)Ggt>Tgt	p.G206C		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	206					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCCTGTGACCAGACATTCCT	0.473000													24	26					8.4185e-14	1.0297e-13	0.163468	1	0
PSG9	5678	broad.mit.edu	37	19	43762557	43762557	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:43762557C>T	ENST00000244293.7	-	4	827	c.761G>A	c.(760-762)gGa>gAa	p.G254E	PSG9_ENST00000291752.5_Missense_Mutation_p.G161E|PSG9_ENST00000270077.3_Missense_Mutation_p.G347E|PSG9_ENST00000418820.2_Missense_Mutation_p.G254E|PSG9_ENST00000443718.3_Missense_Mutation_p.G254E|PSG9_ENST00000593948.1_Missense_Mutation_p.G254E|PSG9_ENST00000596730.1_Missense_Mutation_p.G161E			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	252	Ig-like C2-type 2.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				GAGGTTTTCTCCTGAACGGTA	0.463000													232	31					0	0	0.323286	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129030496	129030496	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:129030496A>C	ENST00000274487.4	+	19	3029	c.2884A>C	c.(2884-2886)Acc>Ccc	p.T962P	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	962	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CAAATACTTAACCAAGCCAGA	0.383000													17	64					0	0	0.175082	0	0
ERVFRD-1	405754	broad.mit.edu	37	6	11105476	11105476	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:11105476G>T	ENST00000472091.1	-	2	443	c.68C>A	c.(67-69)cCg>cAg	p.P23Q	SMIM13_ENST00000416247.2_Intron|ERVFRD-1_ENST00000542862.1_Missense_Mutation_p.P23Q	NM_207582.2	NP_997465.1	P60508	EFRD1_HUMAN		23						integral to membrane|plasma membrane|virion				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(4)|stomach(1)	15						TTCCAATAACGGGAAATCAGG	0.502000													25	66					9.57634e-11	1.11037e-10	0.279207	1	0
ZDBF2	57683	broad.mit.edu	37	2	207172478	207172478	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:207172478G>T	ENST00000374423.3	+	5	3612	c.3226G>T	c.(3226-3228)Ggt>Tgt	p.G1076C		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1076							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CAGTAAATCAGGTGATTCTAA	0.338000													31	59					8.58068e-18	1.1105e-17	0.125774	1	0
SLC17A8	246213	broad.mit.edu	37	12	100811813	100811813	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:100811813A>C	ENST00000323346.5	+	11	1617	c.1304A>C	c.(1303-1305)aAt>aCt	p.N435T	SLC17A8_ENST00000392989.3_Missense_Mutation_p.N385T|SLC17A8_ENST00000552697.1_3'UTR	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	435					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						GTAGGTTTTAATGTCAACCAC	0.463000													16	124					0	0	0.175082	0	0
RAB30	27314	broad.mit.edu	37	11	82708265	82708265	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:82708265C>A	ENST00000533486.1	-	3	378		c.e3+1		RAB30_ENST00000534141.1_Splice_Site|RAB30_ENST00000260056.2_Splice_Site|RAB30_ENST00000532548.1_Splice_Site|RAB30_ENST00000525117.1_Splice_Site|RAB30_ENST00000527633.1_Splice_Site|RP11-659G9.3_ENST00000527550.1_RNA	NM_014488.3	NP_055303.2	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family						protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						agttcccttacCTGAGTGAAT	0.473000													48	94					2.12129e-23	2.97268e-23	0.323286	1	0
CPED1	79974	broad.mit.edu	37	7	120906837	120906837	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:120906837C>A	ENST00000310396.5	+	20	3075	c.2608C>A	c.(2608-2610)Caa>Aaa	p.Q870K		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		CAATCACCTGCAAATTATTCA	0.358000													128	152					3.60366e-59	6.29116e-59	0.323286	1	0
ZNF516	9658	broad.mit.edu	37	18	74154036	74154036	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:74154036C>A	ENST00000443185.2	-	3	1292	c.975G>T	c.(973-975)gaG>gaT	p.E325D	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	325					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CGACGATCACCTCCTCCTGGA	0.607000													19	57					5.45024e-15	6.79251e-15	0.279207	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140755818	140755818	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140755818G>T	ENST00000517434.1	+	1	2168	c.2168G>T	c.(2167-2169)cGc>cTc	p.R723L	PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACAAGTCACGCCTGCTGCAG	0.647000													30	33					1.68508e-10	1.94148e-10	0.279185	1	0
CHST11	50515	broad.mit.edu	37	12	105151495	105151495	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:105151495G>T	ENST00000303694.5	+	3	1412	c.973G>T	c.(973-975)Gag>Tag	p.E325*	CHST11_ENST00000549260.1_Nonsense_Mutation_p.E320*	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	325					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						CATCAGCTCAGAGCACCAAAC	0.463000													42	41					3.77016e-25	5.36589e-25	0.312237	1	0
RYR1	6261	broad.mit.edu	37	19	38980058	38980058	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:38980058A>G	ENST00000355481.4	+	35	5920	c.5789A>G	c.(5788-5790)aAg>aGg	p.K1930R	RYR1_ENST00000359596.3_Missense_Mutation_p.K1930R|RYR1_ENST00000360985.3_Missense_Mutation_p.K1930R	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1930	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTCCAGATGAAGTTGCCAGAG	0.537000													59	29					0	0	0.323286	0	0
CHD6	84181	broad.mit.edu	37	20	40033947	40033947	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:40033947C>T	ENST00000373233.3	-	37	7611	c.7434G>A	c.(7432-7434)ctG>ctA	p.L2478L	CHD6_ENST00000480022.1_5'UTR	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	2478					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GAAGTCCTACCAGGTCCATCC	0.567000													11	79					0	0	0.093190	0	0
FH	2271	broad.mit.edu	37	1	241677012	241677012	+	Splice_Site	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:241677012G>A	ENST00000366560.3	-	3	307	c.267_splice	c.e3-1	p.T90_splice	FH_ENST00000493477.1_5'UTR	NM_000143.3	NP_000134.2	P07954	FUMH_HUMAN	fumarate hydratase	90					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(2)	26	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		AATAACTGGGGTCTAAAATTA	0.328000			"""Mis, N, F"""			"""lieomyomatosis, renal"""			Hereditary Leiomyomatosis and Renal Cell Cancer				22	134					0	0	0.279207	0	0
GRAMD3	65983	broad.mit.edu	37	5	125824489	125824489	+	Splice_Site	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:125824489A>T	ENST00000285689.3	+	13	1624		c.e13-1		GRAMD3_ENST00000513040.1_Splice_Site|GRAMD3_ENST00000502348.1_Splice_Site|RP11-517I3.1_ENST00000515808.1_RNA|GRAMD3_ENST00000515200.1_Splice_Site|GRAMD3_ENST00000511134.1_Splice_Site|GRAMD3_ENST00000542322.1_Splice_Site|GRAMD3_ENST00000543198.1_Intron|RP11-517I3.1_ENST00000512500.1_RNA|GRAMD3_ENST00000544396.1_Splice_Site	NM_023927.2	NP_076416.2	Q96HH9	GRAM3_HUMAN	GRAM domain containing 3											breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0401)|OV - Ovarian serous cystadenocarcinoma(64;0.0604)|all cancers(49;0.108)		TTTTTCTTACAGACAGGCAGC	0.358000													22	35					0	0	0.294199	0	0
AARS2	57505	broad.mit.edu	37	6	44270607	44270607	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:44270607T>A	ENST00000244571.4	-	17	2298	c.2296A>T	c.(2296-2298)Atc>Ttc	p.I766F	TMEM151B_ENST00000438774.2_Intron	NM_020745.3	NP_065796.1	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	766					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CGGTCCCCGATGATAACCAGG	0.617000													5	18					0	0	0.248553	0	0
OR6C3	254786	broad.mit.edu	37	12	55725638	55725638	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55725638C>T	ENST00000379667.1	+	1	154	c.154C>T	c.(154-156)Ctg>Ttg	p.L52L		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						GGACTCCCATCTGCAGACACC	0.393000													100	220					0	0	0.323286	0	0
RFX6	222546	broad.mit.edu	37	6	117243247	117243247	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:117243247A>C	ENST00000332958.2	+	13	1386	c.1370A>C	c.(1369-1371)aAg>aCg	p.K457T		NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	457					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						GATCTCCTTAAGAAGAATGCC	0.338000													21	81					0	0	0.309145	0	0
SCN11A	11280	broad.mit.edu	37	3	38941498	38941498	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:38941498A>C	ENST00000450244.1	-	13	2107	c.1909T>G	c.(1909-1911)Ttt>Gtt	p.F637V	SCN11A_ENST00000456224.3_Missense_Mutation_p.F637V|SCN11A_ENST00000444237.2_Missense_Mutation_p.F637V|SCN11A_ENST00000302328.3_Missense_Mutation_p.F637V			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	637					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCTCGGCGAAAGTAGTGGTAG	0.423000													10	109					0	0	0.093190	0	0
WWC3	55841	broad.mit.edu	37	X	10066580	10066580	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:10066580G>T	ENST00000380861.4	+	8	1083	c.692G>T	c.(691-693)cGa>cTa	p.R231L	WWC3_ENST00000454666.1_Missense_Mutation_p.R231L	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	231										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						CTTGTAGACCGAGTCAGACTT	0.368000													17	25					5.26018e-13	6.34623e-13	0.234183	1	0
TMEM133	83935	broad.mit.edu	37	11	100863141	100863141	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:100863141G>T	ENST00000303130.2	+	1	331	c.102G>T	c.(100-102)ttG>ttT	p.L34F		NM_032021.2	NP_114410.1	Q9H2Q1	TM133_HUMAN	transmembrane protein 133	34						integral to membrane				kidney(2)|large_intestine(1)|lung(1)|prostate(1)	5		Acute lymphoblastic leukemia(157;0.000869)|all_hematologic(158;0.014)		BRCA - Breast invasive adenocarcinoma(274;0.0675)		CTTTCCCCTTGACTAAAGGTT	0.418000													46	112					2.13384e-23	2.98622e-23	0.323286	1	0
ENPEP	2028	broad.mit.edu	37	4	111441430	111441430	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:111441430T>A	ENST00000265162.5	+	10	1977	c.1635T>A	c.(1633-1635)ccT>ccA	p.P545P		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	545					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TGGGTTATCCTGTGCTTAACG	0.428000													15	53					0	0	0.146539	0	0
FAM3B	54097	broad.mit.edu	37	21	42720533	42720533	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:42720533C>T	ENST00000398652.3	+	8	683	c.617C>T	c.(616-618)gCc>gTc	p.A206V	FAM3B_ENST00000479810.2_3'UTR|FAM3B_ENST00000357985.2_Missense_Mutation_p.A167V|FAM3B_ENST00000398646.3_Missense_Mutation_p.A190V|FAM3B_ENST00000398647.3_Missense_Mutation_p.A119V			P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	167					apoptosis|insulin secretion	extracellular space	cytokine activity	p.A167G(1)		central_nervous_system(2)|endometrium(1)|lung(2)	5		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				AATAACGATGCCAAGAATGCC	0.468000													44	52					0	0	0.323286	0	0
RYR2	6262	broad.mit.edu	37	1	237791135	237791135	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:237791135C>T	ENST00000366574.2	+	41	6512	c.6195C>T	c.(6193-6195)acC>acT	p.T2065T	RYR2_ENST00000360064.6_Silent_p.T2063T|RYR2_ENST00000542537.1_Silent_p.T2049T	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2065	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTTCTGAGACCATGGTCCGAT	0.468000													29	73					0	0	0.153744	0	0
ARV1	64801	broad.mit.edu	37	1	231115007	231115007	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:231115007G>T	ENST00000310256.2	+	1	213	c.156G>T	c.(154-156)gtG>gtT	p.V52V	ARV1_ENST00000497753.1_3'UTR|ARV1_ENST00000366658.2_Silent_p.V52V	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	52					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		ACCACGGTGTGCTGAAGATAA	0.572000													52	184					9.53978e-28	1.39296e-27	0.323286	1	0
TTN	7273	broad.mit.edu	37	2	179471967	179471967	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179471967G>T	ENST00000589042.1	-	278	53586	c.53362C>A	c.(53362-53364)Cca>Aca	p.P17788T	TTN_ENST00000342175.6_Missense_Mutation_p.P8915T|TTN_ENST00000359218.5_Missense_Mutation_p.P8848T|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P16147T|TTN_ENST00000460472.2_Missense_Mutation_p.P8723T|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.P15220T|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16147	Ig-like 104.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATCTTCTGGATCAGACCAG	0.373000													156	188					1.05211e-58	1.83467e-58	0.323286	1	0
ZNF208	7757	broad.mit.edu	37	19	22156942	22156942	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:22156942C>G	ENST00000397126.4	-	4	1042	c.894G>C	c.(892-894)tcG>tcC	p.S298S	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAGTAAGAGTCGAGACCTTAC	0.383000													79	86					0	0	0.323286	0	0
MAS1L	116511	broad.mit.edu	37	6	29454895	29454895	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:29454895A>C	ENST00000377127.3	-	1	843	c.785T>G	c.(784-786)gTc>gGc	p.V262G		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	262						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						CACCGCATAGACCCTGGTGGC	0.537000													4	58					0	0	0.184627	0	0
UBA3	9039	broad.mit.edu	37	3	69105182	69105182	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:69105182A>G	ENST00000361055.4	-	16	1271	c.1217T>C	c.(1216-1218)cTa>cCa	p.L406P	UBA3_ENST00000349511.4_Missense_Mutation_p.L392P|UBA3_ENST00000415609.2_Missense_Mutation_p.L365P|CTD-2013N24.2_ENST00000595925.1_RNA|UBA3_ENST00000540295.1_Missense_Mutation_p.L229P	NM_003968.3	NP_003959.3	Q8TBC4	UBA3_HUMAN	ubiquitin-like modifier activating enzyme 3	406	Interaction with UBE2M core domain.				protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		TTTTCCCTCTAGGGTGGCTGT	0.269000													4	39					0	0	0.150653	0	0
CRISP1	167	broad.mit.edu	37	6	49803073	49803073	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:49803073G>C	ENST00000335847.4	-	8	807	c.706C>G	c.(706-708)Cta>Gta	p.L236V	CRISP1_ENST00000505118.1_Missense_Mutation_p.L236V|CRISP1_ENST00000507853.1_3'UTR|CRISP1_ENST00000355791.2_Missense_Mutation_p.L236V|CRISP1_ENST00000329411.5_3'UTR|CRISP1_ENST00000536021.1_3'UTR	NM_001131.2	NP_001122.2	P54107	CRIS1_HUMAN	cysteine-rich secretory protein 1	236					fusion of sperm to egg plasma membrane	extracellular space				endometrium(1)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0358)					TTACAGAATAGGATAGTTGTT	0.393000													167	93					0	0	0.323286	0	0
KRT71	112802	broad.mit.edu	37	12	52943834	52943834	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:52943834A>G	ENST00000267119.5	-	2	704	c.635T>C	c.(634-636)gTa>gCa	p.V212A		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	212	Coil 1B.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		GTCCTCCACTACGTCCCGCAC	0.607000													85	171					0	0	0.323286	0	0
PAX4	5078	broad.mit.edu	37	7	127255363	127255363	+	Translation_Start_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:127255363G>T	ENST00000463946.1	-	0	361				PAX4_ENST00000341640.2_Intron|PAX4_ENST00000338516.3_Intron|PAX4_ENST00000378740.2_Intron			O43316	PAX4_HUMAN	paired box 4						cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						GAAGCCCTCAGAGCCTGCAAC	0.582000													24	59					3.65163e-15	4.56196e-15	0.116897	1	0
NPEPPS	9520	broad.mit.edu	37	17	45668161	45668161	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:45668161G>T	ENST00000322157.4	+	10	1411	c.1174G>T	c.(1174-1176)Gag>Tag	p.E392*	NPEPPS_ENST00000525037.1_3'UTR|NPEPPS_ENST00000544660.1_Nonsense_Mutation_p.E312*|NPEPPS_ENST00000530173.1_Nonsense_Mutation_p.E388*	NM_006310.3	NP_006301.3	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	392					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	27						CTGCTTCCCAGAGTATGATAT	0.408000													25	127					9.39024e-22	1.28566e-21	0.279185	1	0
SLC22A6	9356	broad.mit.edu	37	11	62747341	62747341	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:62747341T>G	ENST00000377871.3	-	7	1383	c.1117A>C	c.(1117-1119)Atc>Ctc	p.I373L	SLC22A6_ENST00000360421.4_Missense_Mutation_p.I373L|SLC22A6_ENST00000537349.1_5'UTR|SLC22A6_ENST00000421062.2_Missense_Mutation_p.I373L|SLC22A6_ENST00000458333.2_Missense_Mutation_p.I373L	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	373					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GCACCAAAGATCACCTGGATT	0.572000													21	95					0	0	0.219247	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263698	140263698	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140263698G>T	ENST00000289272.2	+	1	1845	c.1845G>T	c.(1843-1845)gcG>gcT	p.A615A	PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.A615A|PCDHA4_ENST00000530339.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTGGCGGCGGTCGGCGCGC	0.697000													42	45					8.52529e-16	1.07635e-15	0.323286	1	0
PAG1	55824	broad.mit.edu	37	8	81888954	81888954	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:81888954G>A	ENST00000220597.4	-	9	1834	c.1124C>T	c.(1123-1125)cCa>cTa	p.P375L		NM_018440.3	NP_060910.3	Q9NWQ8	PAG1_HUMAN	phosphoprotein associated with glycosphingolipid microdomains 1	375					epidermal growth factor receptor signaling pathway|intracellular signal transduction|T cell receptor signaling pathway	integral to membrane|intracellular|membrane raft|plasma membrane	SH2 domain binding|SH3/SH2 adaptor activity			breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(2)	11	Lung NSC(7;5.76e-06)|all_lung(9;2e-05)		BRCA - Breast invasive adenocarcinoma(6;0.0567)|Epithelial(68;0.0634)|all cancers(69;0.197)			CCTCCCTGCTGGTGGAAGTGT	0.527000													55	62					0	0	0.323286	0	0
FAM78B	149297	broad.mit.edu	37	1	166039936	166039936	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:166039936C>G	ENST00000338353.3	-	3	917	c.328G>C	c.(328-330)Gtg>Ctg	p.V110L	FAM78B_ENST00000354422.3_Missense_Mutation_p.V110L			Q5VT40	FA78B_HUMAN	family with sequence similarity 78, member B	110										central_nervous_system(1)|endometrium(5)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(923;0.0813)|Acute lymphoblastic leukemia(8;0.155)					GGGTAGCTCACCCCATCTGAG	0.512000													62	173					0	0	0.323286	0	0
TRIM10	10107	broad.mit.edu	37	6	30128459	30128459	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:30128459G>T	ENST00000449742.2	-	1	252	c.177C>A	c.(175-177)ctC>ctA	p.L59L	TRIM10_ENST00000376704.3_Silent_p.L59L	NM_006778.3	NP_006769.2	Q9UDY6	TRI10_HUMAN	tripartite motif containing 10	59						cytoplasm	zinc ion binding			ovary(1)	1						GTTCTTTGCAGAGTGGGCAAG	0.612000													107	263					6.00419e-47	9.97585e-47	0.323286	1	0
PLCL1	5334	broad.mit.edu	37	2	198949433	198949433	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:198949433C>A	ENST00000428675.1	+	2	1590	c.1192C>A	c.(1192-1194)Caa>Aaa	p.Q398K	PLCL1_ENST00000437704.2_Missense_Mutation_p.Q300K	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	398	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GAAGGTTGCCCAAGATATGAC	0.418000													81	127					5.42381e-49	9.09942e-49	0.323286	1	0
ZNF549	256051	broad.mit.edu	37	19	58048848	58048848	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:58048848A>G	ENST00000376233.3	+	4	657	c.476A>G	c.(475-477)cAc>cGc	p.H159R	ZNF549_ENST00000602149.1_Intron|ZNF549_ENST00000594943.1_Intron|ZNF550_ENST00000601415.1_Intron|ZNF549_ENST00000240719.3_Missense_Mutation_p.H146R	NM_001199295.1	NP_001186224.1	Q6P9A3	ZN549_HUMAN	zinc finger protein 549	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGAGAGAAACACATCAGAAAG	0.458000													66	78					0	0	0.323286	0	0
FREM1	158326	broad.mit.edu	37	9	14859441	14859441	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:14859441C>A	ENST00000380881.4	-	5	1186	c.371G>T	c.(370-372)tGg>tTg	p.W124L	FREM1_ENST00000422223.2_Missense_Mutation_p.W124L|FREM1_ENST00000380880.3_Missense_Mutation_p.W124L			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	124					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GAGATAGACCCACAGGATAAA	0.403000													370	602					6.87349e-169	1.27545e-168	0.323286	1	0
ENC1	8507	broad.mit.edu	37	5	73931166	73931166	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:73931166C>A	ENST00000302351.4	-	2	2275	c.1145G>T	c.(1144-1146)gGc>gTc	p.G382V	ENC1_ENST00000537006.1_Missense_Mutation_p.G382V|ENC1_ENST00000510316.1_Missense_Mutation_p.G309V	NM_003633.3	NP_003624.1	O14682	ENC1_HUMAN	ectodermal-neural cortex 1 (with BTB domain)	382					nervous system development	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	20		all_lung(232;0.0154)|Lung NSC(167;0.0331)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;1.45e-59)		TTCAGCAGAGCCATGGCCAAA	0.587000													16	34					5.03518e-11	5.88008e-11	0.189662	1	0
VCAM1	7412	broad.mit.edu	37	1	101188704	101188704	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:101188704C>G	ENST00000294728.2	+	3	570	c.469C>G	c.(469-471)Cat>Gat	p.H157D	VCAM1_ENST00000370115.1_Missense_Mutation_p.H157D|VCAM1_ENST00000347652.2_Missense_Mutation_p.H157D|VCAM1_ENST00000370119.4_Missense_Mutation_p.H95D	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	157	Ig-like C2-type 2.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	GAAAGGAGATCATCTCATGAA	0.473000													47	23					0	0	0.323286	0	0
ZNF346	23567	broad.mit.edu	37	5	176468840	176468840	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:176468840A>T	ENST00000503039.1	+	4	420	c.416A>T	c.(415-417)aAg>aTg	p.K139M	ZNF346_ENST00000503425.1_Intron|ZNF346_ENST00000261948.4_Missense_Mutation_p.K139M|ZNF346_ENST00000358149.3_Missense_Mutation_p.K114M|ZNF346_ENST00000506693.1_Intron|ZNF346_ENST00000511834.1_Missense_Mutation_p.K114M|ZNF346_ENST00000512315.1_Intron			Q9UL40	ZN346_HUMAN	zinc finger protein 346	114						cytoplasm|nucleolus	double-stranded RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|prostate(1)|urinary_tract(1)	14	all_cancers(89;6.3e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGACATTAAAGGGGGAAACG	0.448000													8	13					0	0	0.307466	0	0
DBN1	1627	broad.mit.edu	37	5	176894570	176894570	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:176894570C>A	ENST00000292385.5	-	6	1004	c.395G>T	c.(394-396)gGg>gTg	p.G132V	DBN1_ENST00000393565.1_Missense_Mutation_p.G130V|DBN1_ENST00000309007.5_Missense_Mutation_p.G130V	NM_080881.2	NP_543157.1	Q16643	DREB_HUMAN	drebrin 1	130	ADF-H.				actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGCCGCTGCCCGATGGCACC	0.642000													3	1					1.23904e-05	1.31776e-05	0.184627	1	0
MMP16	4325	broad.mit.edu	37	8	89179959	89179959	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:89179959A>G	ENST00000286614.6	-	4	929	c.648T>C	c.(646-648)atT>atC	p.I216I	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	216					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						TATCTCCTCCAATTCCTGGTC	0.408000													24	33					0	0	0.294199	0	0
FERD3L	222894	broad.mit.edu	37	7	19184523	19184523	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:19184523C>G	ENST00000275461.3	-	1	521	c.463G>C	c.(463-465)Gag>Cag	p.E155Q	AC003986.5_ENST00000452700.1_RNA	NM_152898.2	NP_690862.1	Q96RJ6	FER3L_HUMAN	Fer3-like bHLH transcription factor	155					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(4)|large_intestine(8)|lung(16)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	35						TCCAAGAGCTCGGTCATGAAG	0.592000													38	114					0	0	0.323286	0	0
SPTA1	6708	broad.mit.edu	37	1	158641213	158641213	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158641213A>T	ENST00000368148.3	-	12	1699	c.1519T>A	c.(1519-1521)Tca>Aca	p.S507T	SPTA1_ENST00000368147.3_Missense_Mutation_p.S507T	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	507					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTGCCCAGTGAGTTTCCCAGA	0.468000													26	70					0	0	0.125774	0	0
SYNE1	23345	broad.mit.edu	37	6	152772294	152772294	+	Missense_Mutation	SNP	T	T	C	rs143093185	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:152772294T>C	ENST00000367255.5	-	26	3675	c.3074A>G	c.(3073-3075)gAt>gGt	p.D1025G	SYNE1_ENST00000448038.1_Missense_Mutation_p.D1032G|SYNE1_ENST00000265368.4_Missense_Mutation_p.D1025G|SYNE1_ENST00000367248.3_Missense_Mutation_p.D1015G|SYNE1_ENST00000423061.1_Missense_Mutation_p.D1032G|SYNE1_ENST00000367253.4_Missense_Mutation_p.D1025G|SYNE1_ENST00000341594.5_Missense_Mutation_p.D1091G|SYNE1_ENST00000413186.2_Missense_Mutation_p.D1025G	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1025					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTTCTCCACATCAATCTTCAG	0.413000										HNSCC(10;0.0054)			5	190					0	0	0.184627	0	0
FAT1	2195	broad.mit.edu	37	4	187521300	187521300	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:187521300A>C	ENST00000441802.2	-	22	12064	c.11855T>G	c.(11854-11856)tTt>tGt	p.F3952C		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	3952	Laminin G-like.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GTGGCCACCAAAAAACACATA	0.478000										HNSCC(5;0.00058)			5	103					0	0	0.307466	0	0
GAL3ST4	79690	broad.mit.edu	37	7	99758406	99758406	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:99758406C>A	ENST00000423751.1	-	3	557	c.302G>T	c.(301-303)gGg>gTg	p.G101V	GAL3ST4_ENST00000360039.4_Silent_p.G202G|GAL3ST4_ENST00000426974.2_Silent_p.G140G|GAL3ST4_ENST00000411994.1_Missense_Mutation_p.G101V|GAL3ST4_ENST00000413800.1_Silent_p.G202G			Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	264					cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(5)|prostate(1)|upper_aerodigestive_tract(1)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CGTAGTGGTCCCCACGGGCCC	0.562000													21	71					1.55795e-14	1.93153e-14	0.234183	1	0
DUSP27	92235	broad.mit.edu	37	1	167096180	167096180	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:167096180C>A	ENST00000361200.2	+	6	1978	c.1812C>A	c.(1810-1812)aaC>aaA	p.N604K	DUSP27_ENST00000443333.1_Missense_Mutation_p.N604K|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.N604K			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	604					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GCAGTGAGAACAAGGAGGAGG	0.612000													67	35					1.48005e-37	2.35303e-37	0.323286	1	0
CR1	1378	broad.mit.edu	37	1	207680057	207680057	+	Splice_Site	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:207680057A>T	ENST00000367049.4	+	3	301		c.e3-1		CR1_ENST00000367051.1_Splice_Site|CR1_ENST00000367052.1_Splice_Site|CR1_ENST00000400960.2_Splice_Site|CR1_ENST00000367053.1_Splice_Site|CR1_ENST00000367050.4_Splice_Site	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)						complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TCTTTCCTGTAGGTAAATCAT	0.393000													94	259					0	0	0.323286	0	0
PDE1C	5137	broad.mit.edu	37	7	31793148	31793148	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:31793148A>T	ENST00000396193.1	-	19	2753	c.2160T>A	c.(2158-2160)cgT>cgA	p.R720R	PDE1C_ENST00000396191.1_Silent_p.R660R|PDE1C_ENST00000321453.7_Silent_p.R660R	NM_001191058.1	NP_001177987.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	660					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GTTTAAAATGACGCAAAGGAG	0.488000													135	127					0	0	0.323286	0	0
COL5A3	50509	broad.mit.edu	37	19	10087928	10087928	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:10087928T>A	ENST00000264828.3	-	44	3350	c.3265A>T	c.(3265-3267)Agt>Tgt	p.S1089C		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	1089	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			TCGCCTTTACTCCCCTTGTGT	0.602000													141	17					0	0	0.323286	0	0
CACNA1C	775	broad.mit.edu	37	12	2675717	2675717	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:2675717C>T	ENST00000399655.1	+	12	1903	c.1638C>T	c.(1636-1638)taC>taT	p.Y546Y	CACNA1C_ENST00000399637.1_Silent_p.Y546Y|CACNA1C_ENST00000399597.1_Silent_p.Y546Y|CACNA1C_ENST00000344100.3_Silent_p.Y546Y|CACNA1C_ENST00000327702.7_Silent_p.Y546Y|CACNA1C_ENST00000399601.1_Silent_p.Y546Y|CACNA1C_ENST00000399621.1_Silent_p.Y546Y|CACNA1C_ENST00000399644.1_Silent_p.Y546Y|CACNA1C_ENST00000399641.1_Silent_p.Y546Y|CACNA1C_ENST00000399629.1_Silent_p.Y546Y|CACNA1C_ENST00000399617.1_Silent_p.Y546Y|CACNA1C_ENST00000399638.1_Silent_p.Y546Y|CACNA1C_ENST00000402845.3_Silent_p.Y546Y|CACNA1C_ENST00000406454.3_Silent_p.Y546Y|CACNA1C_ENST00000399591.1_Silent_p.Y546Y|CACNA1C_ENST00000399649.1_Silent_p.Y546Y|CACNA1C_ENST00000399634.1_Silent_p.Y546Y|CACNA1C_ENST00000480911.1_Silent_p.Y546Y|CACNA1C_ENST00000347598.4_Silent_p.Y546Y|CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000399606.1_Silent_p.Y546Y|CACNA1C_ENST00000335762.5_Silent_p.Y571Y|CACNA1C_ENST00000399595.1_Silent_p.Y546Y|CACNA1C_ENST00000399603.1_Silent_p.Y546Y	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	546					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CTGAGCACTACAACCAGCCCA	0.587000													4	6					0	0	0.184627	0	0
PSG3	5671	broad.mit.edu	37	19	43242948	43242948	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:43242948A>G	ENST00000327495.5	-	2	542	c.358T>C	c.(358-360)Tac>Cac	p.Y120H	PSG3_ENST00000490592.1_5'UTR|PSG3_ENST00000595140.1_Missense_Mutation_p.Y120H	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	120	Ig-like V-type.				defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				TGTAAGGTGTAGGATCCTGCG	0.478000													277	934					0	0	0.323286	0	0
MYO1E	4643	broad.mit.edu	37	15	59494582	59494582	+	Silent	SNP	C	C	G	rs142116200	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:59494582C>G	ENST00000288235.4	-	16	2040	c.1641G>C	c.(1639-1641)ccG>ccC	p.P547P		NM_004998.3	NP_004989.2	Q12965	MYO1E_HUMAN	myosin IE	547	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(6)|lung(10)|pancreas(2)|prostate(1)|urinary_tract(1)	33				all cancers(107;0.207)		GCAGATTTTCCGGAAATAAAG	0.408000													5	82					0	0	0.217242	0	0
MAGEB18	286514	broad.mit.edu	37	X	26157432	26157432	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:26157432A>C	ENST00000325250.1	+	2	517	c.330A>C	c.(328-330)aaA>aaC	p.K110N		NM_173699.3	NP_775970.1	Q96M61	MAGBI_HUMAN	melanoma antigen family B, 18	110	MAGE.						protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(17)|skin(2)|stomach(1)|urinary_tract(2)	33						TAAACAAGAAAGTAGTGTCGC	0.413000													5	33					0	0	0.184627	0	0
TAAR8	83551	broad.mit.edu	37	6	132873854	132873854	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:132873854C>A	ENST00000275200.1	+	1	23	c.23C>A	c.(22-24)cCt>cAt	p.P8H		NM_053278.1	NP_444508.1	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	8						plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		TTTTCCCAACCTGTTGTGCAG	0.403000													25	83					7.01153e-11	8.13285e-11	0.125774	1	0
CACNG5	27091	broad.mit.edu	37	17	64880797	64880797	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:64880797A>C	ENST00000169565.3	+	4	589	c.589A>C	c.(589-591)Agt>Cgt	p.S197R	CACNG5_ENST00000533854.1_Intron|CACNG5_ENST00000307139.3_Intron			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	200				SAGVMSVYLFMKRYTAEDMYRPHPGFYRPRLSNCSDYSGQF LHPDAWVRGRSPSDISSEASLQMNSNYPALLKCPDYDQMSS SPC -> VKPVTLSMDRLGLGTAPLSRGEWGWGRRDIPQPF WTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHF PPHSSCVLCRPQPREMRQAPAASPSSAVFSL (in Ref. 1; AAF03089).	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CGTCACCCTAAGTATGGATAG	0.577000													52	80					0	0	0.323286	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542197	133542197	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:133542197A>G	ENST00000409261.1	-	14	2560	c.2187T>C	c.(2185-2187)taT>taC	p.Y729Y	NCKAP5_ENST00000317721.6_Silent_p.Y729Y|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	729							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TAAAGAAAGTATAGTCTCTTG	0.423000													77	219					0	0	0.323286	0	0
CYP2S1	29785	broad.mit.edu	37	19	41712285	41712285	+	Silent	SNP	G	G	A	rs111879045	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:41712285G>A	ENST00000310054.4	+	9	1623	c.1407G>A	c.(1405-1407)ccG>ccA	p.P469P	CYP2S1_ENST00000542619.1_Silent_p.P194P	NM_030622.6	NP_085125.1	Q96SQ9	CP2S1_HUMAN	cytochrome P450, family 2, subfamily S, polypeptide 1	469					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity			breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(2)	14						CGTGCCCGCCGGACACCCTGA	0.612000													4	366					0	0	0.248553	0	0
PLXNA4	91584	broad.mit.edu	37	7	131887591	131887591	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:131887591G>T	ENST00000359827.3	-	12	3362	c.2400C>A	c.(2398-2400)caC>caA	p.H800Q	PLXNA4_ENST00000321063.4_Missense_Mutation_p.H800Q			Q9HCM2	PLXA4_HUMAN	plexin A4	800						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						ACTTGTAGAGGTGAACTGCAG	0.632000													15	36					1.3612e-06	1.47349e-06	0.132662	1	0
C15orf60	283677	broad.mit.edu	37	15	73766187	73766187	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:73766187T>A	ENST00000331090.6	+	2	202	c.174T>A	c.(172-174)aaT>aaA	p.N58K	C15orf60_ENST00000560581.1_Missense_Mutation_p.N58K	NM_001042367.1	NP_001035826.1	Q7Z4M0	CO060_HUMAN	chromosome 15 open reading frame 60	58										endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|pancreas(1)|prostate(2)	17						TTGATTCCAATGAAGAATCTG	0.318000													15	20					0	0	0.160694	0	0
GRIK1	2897	broad.mit.edu	37	21	30959695	30959695	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:30959695A>G	ENST00000399914.1	-	11	2260	c.1739T>C	c.(1738-1740)gTg>gCg	p.V580A	GRIK1_ENST00000327783.4_Missense_Mutation_p.V595A|GRIK1_ENST00000389124.2_Missense_Mutation_p.V595A|GRIK1_ENST00000399913.1_Missense_Mutation_p.V595A|GRIK1_ENST00000399907.1_Missense_Mutation_p.V595A|GRIK1_ENST00000535441.1_Missense_Mutation_p.V597A|GRIK1_ENST00000389125.3_Missense_Mutation_p.V580A|GRIK1_ENST00000399909.1_Missense_Mutation_p.V580A|GRIK1_ENST00000309434.7_Missense_Mutation_p.V597A			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	595					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CCTTGCAATCACAAAGAGTAC	0.443000													32	43					0	0	0.163468	0	0
COL7A1	1294	broad.mit.edu	37	3	48627953	48627953	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:48627953C>A	ENST00000328333.8	-	14	1952	c.1845G>T	c.(1843-1845)agG>agT	p.R615S	COL7A1_ENST00000454817.1_Missense_Mutation_p.R615S	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	615	Fibronectin type-III 5.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CCCAGGCCACCCTCACTCGCG	0.592000													8	39					3.07112e-06	3.29908e-06	0.080935	1	0
IGHV2-26	28455	broad.mit.edu	37	14	106757832	106757832	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:106757832G>T	ENST00000390611.2	-	0	198																											GGGGGCTGACGGATCCAGCTC	0.547000													43	45					4.6707e-30	6.97788e-30	0.323286	1	0
OR5W2	390148	broad.mit.edu	37	11	55681959	55681959	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55681959C>T	ENST00000344514.1	-	1	99	c.100G>A	c.(100-102)Gtt>Att	p.V34I		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						ATGATATAAACAGCCAAGAAT	0.353000													53	109					0	0	0.323286	0	0
TRPM1	4308	broad.mit.edu	37	15	31342759	31342759	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:31342759C>T	ENST00000542188.1	-	11	1654	c.1341G>A	c.(1339-1341)acG>acA	p.T447T	TRPM1_ENST00000397795.2_Silent_p.T408T|TRPM1_ENST00000256552.6_Silent_p.T430T	NM_001252020.1	NP_001238949.1	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel, subfamily M, member 1	408					cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			NS(2)|breast(3)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(15)|lung(48)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(3)	99		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		CTTTGCTGTCCGTCGGGGGTG	0.557000													12	75					0	0	0.146539	0	0
KRT81	3887	broad.mit.edu	37	12	52681806	52681806	+	Missense_Mutation	SNP	G	G	T	rs144716678	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:52681806G>T	ENST00000327741.5	-	5	930	c.862C>A	c.(862-864)Cgc>Agc	p.R288S	KRT86_ENST00000423955.2_Intron|KRT86_ENST00000544024.1_Intron	NM_002281.3	NP_002272.2	Q14533	KRT81_HUMAN	keratin 81	288	Coil 2.|Rod.					keratin filament	protein binding|structural molecule activity			breast(2)|endometrium(3)|large_intestine(3)|lung(6)|prostate(1)|stomach(1)	16				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCCGGCTGCGGGTGACAATG	0.572000													32	68					6.2361e-21	8.44848e-21	0.257332	1	0
OR4M1	441670	broad.mit.edu	37	14	20249016	20249016	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20249016T>A	ENST00000315957.4	+	1	616	c.535T>A	c.(535-537)Tgt>Agt	p.C179S		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CAGTTACTTCTGTGACATCAC	0.483000													147	639					0	0	0.323286	0	0
IGHV1-45	28466	broad.mit.edu	37	14	106963112	106963112	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:106963112C>A	ENST00000390621.2	-	0	227																											GGGGGCCTGTCGCACCCAGTG	0.552000													70	79					3.00942e-58	5.23605e-58	0.323286	1	0
SPATA31D3	389762	broad.mit.edu	37	9	84564667	84564667	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:84564667C>A	ENST00000585776.1	-	0	942				SPATA31D3_ENST00000334208.4_RNA																							CTATCTTTGTCGGCCAGAATT	0.478000													76	3					5.98988e-27	8.6807e-27	0.323286	1	0
SAGE1	55511	broad.mit.edu	37	X	134994548	134994548	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:134994548G>T	ENST00000535938.1	+	19	2757	c.2590G>T	c.(2590-2592)Gaa>Taa	p.E864*	SAGE1_ENST00000324447.3_Nonsense_Mutation_p.E864*|SAGE1_ENST00000370709.3_Nonsense_Mutation_p.E864*|SAGE1_ENST00000537770.1_Nonsense_Mutation_p.E488*	NM_018666.2	NP_061136.2	Q9NXZ1	SAGE1_HUMAN	sarcoma antigen 1	864										breast(5)|endometrium(5)|large_intestine(10)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	55	Acute lymphoblastic leukemia(192;0.000127)					ACAATTTGTTGAATTTACCAT	0.348000													74	5					5.70515e-31	8.59798e-31	0.323286	1	0
MXRA5	25878	broad.mit.edu	37	X	3241144	3241144	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:3241144G>T	ENST00000217939.6	-	5	2736	c.2582C>A	c.(2581-2583)gCc>gAc	p.A861D		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	861						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CCCCATGCTGGCTGAGGAAAT	0.473000													112	4					8.97248e-49	1.50448e-48	0.323286	1	0
PKD1L1	168507	broad.mit.edu	37	7	47968929	47968929	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:47968929C>A	ENST00000289672.2	-	7	982	c.932G>T	c.(931-933)cGt>cTt	p.R311L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	311					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						CATATGAACACGGAATCCCAG	0.502000													223	177					8.60804e-130	1.59064e-129	0.323286	1	0
IPMK	253430	broad.mit.edu	37	10	59956113	59956113	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:59956113A>G	ENST00000373935.3	-	6	1297	c.975T>C	c.(973-975)taT>taC	p.Y325Y		NM_152230.4	NP_689416.1	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	325						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)	22						GCTTTTTTGTATATATTTTCC	0.368000													86	12					0	0	0.323286	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558885	129558885	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:129558885G>T	ENST00000422113.2	-	9	3161	c.2835C>A	c.(2833-2835)taC>taA	p.Y945*	TMEM132D_ENST00000389441.4_Nonsense_Mutation_p.Y483*	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	945						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GTTTGTGTCTGTATTTTAATG	0.458000													87	159					2.68325e-40	4.33717e-40	0.323286	1	0
IGFBP1	3484	broad.mit.edu	37	7	45928285	45928285	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:45928285G>T	ENST00000275525.3	+	1	330	c.34G>T	c.(34-36)Gta>Tta	p.V12L	IGFBP1_ENST00000457280.1_Missense_Mutation_p.V12L|IGFBP1_ENST00000468955.1_Missense_Mutation_p.V12L	NM_000596.2	NP_000587.1	P08833	IBP1_HUMAN	insulin-like growth factor binding protein 1	12						extracellular space	insulin-like growth factor binding			large_intestine(2)|lung(4)	6						CGTCTGGCTGGTACTGCTCCT	0.711000													7	14					0.00621372	0.00636372	0.058154	1	0
VAC14	55697	broad.mit.edu	37	16	70721913	70721913	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:70721913T>C	ENST00000261776.5	-	19	2527	c.2267A>G	c.(2266-2268)gAg>gGg	p.E756G	VAC14_ENST00000571759.1_5'UTR|VAC14_ENST00000536184.2_Missense_Mutation_p.E188G	NM_018052.3	NP_060522.3	Q08AM6	VAC14_HUMAN	Vac14 homolog (S. cerevisiae)	756					interspecies interaction between organisms	endoplasmic reticulum|endosome membrane|microsome	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(10)|large_intestine(1)|lung(10)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Ovarian(137;0.0699)				CTGGACCTTCTCAAAGTGCTG	0.612000													8	23					0	0	0.080935	0	0
MROH7	374977	broad.mit.edu	37	1	55161094	55161094	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:55161094C>T	ENST00000414150.2	+	17	3173	c.2895C>T	c.(2893-2895)taC>taT	p.Y965Y	MROH7_ENST00000409996.1_Silent_p.Y533Y|MROH7_ENST00000339553.5_Silent_p.Y965Y|MROH7_ENST00000454855.2_Silent_p.Y483Y|MROH7_ENST00000395690.2_Silent_p.Y965Y|MROH7_ENST00000545244.1_Intron|MROH7_ENST00000421030.2_Silent_p.Y965Y					maestro heat-like repeat family member 7																		GCATCCTCTACCTGCTCATCC	0.667000													20	38					0	0	0.294199	0	0
VWA3A	146177	broad.mit.edu	37	16	22144347	22144347	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:22144347G>C	ENST00000389398.5	+	20	2095	c.1999G>C	c.(1999-2001)Gac>Cac	p.D667H	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	667	VWFA 1.					extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CAGTCACACTGACACAGCCGC	0.617000													24	20					0	0	0.116897	0	0
ITGA10	8515	broad.mit.edu	37	1	145534101	145534101	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:145534101C>G	ENST00000369304.3	+	14	1781	c.1606C>G	c.(1606-1608)Caa>Gaa	p.Q536E	ITGA10_ENST00000538811.1_Missense_Mutation_p.Q405E|ITGA10_ENST00000539363.1_Missense_Mutation_p.Q393E	NM_003637.3	NP_003628.2	O75578	ITA10_HUMAN	integrin, alpha 10	536					cell-matrix adhesion|integrin-mediated signaling pathway	integrin complex	collagen binding|receptor activity			NS(1)|breast(2)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GCTGACCCTCCAAGGAACACT	0.527000													24	373					0	0	0.134883	0	0
SMEK1	55671	broad.mit.edu	37	14	91948454	91948454	+	Silent	SNP	C	C	A	rs61757451	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:91948454C>A	ENST00000554684.1	-	4	877	c.381G>T	c.(379-381)tcG>tcT	p.S127S	SMEK1_ENST00000555462.1_Intron|SMEK1_ENST00000554943.1_Silent_p.S127S|SMEK1_ENST00000428424.2_Intron|SMEK1_ENST00000337238.4_Silent_p.S127S			Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	127						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|liver(1)|lung(1)|stomach(1)	6		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		CTAAGCCTGGCGATGACATAT	0.418000													30	83					1.88708e-17	2.4331e-17	0.134883	1	0
CD1A	909	broad.mit.edu	37	1	158224512	158224512	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158224512C>A	ENST00000289429.5	+	1	586	c.53C>A	c.(52-54)gCa>gAa	p.A18E		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	18					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GATGGCAATGCAGACGGTAAG	0.453000													107	346					8.84126e-78	1.58274e-77	0.323286	1	0
NEB	4703	broad.mit.edu	37	2	152522015	152522015	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:152522015C>A	ENST00000397345.3	-	42	5272	c.5070G>T	c.(5068-5070)ggG>ggT	p.G1690G	NEB_ENST00000172853.10_Silent_p.G1690G|NEB_ENST00000409198.1_Silent_p.G1690G|NEB_ENST00000604864.1_Silent_p.G1690G|NEB_ENST00000427231.2_Silent_p.G1690G|NEB_ENST00000603639.1_Silent_p.G1690G	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	1690					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CCCAGCCGATCCCTTTCATCC	0.443000													12	10					5.61819e-17	7.20179e-17	0.324025	1	0
HIVEP1	3096	broad.mit.edu	37	6	12120865	12120865	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:12120865A>T	ENST00000379388.2	+	4	1169	c.837A>T	c.(835-837)tcA>tcT	p.S279S		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	279					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				CAATGCAGTCAGCTTCTCATT	0.438000													75	170					0	0	0.323286	0	0
NOS2	4843	broad.mit.edu	37	17	26094792	26094792	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:26094792C>A	ENST00000313735.6	-	18	2339	c.2106G>T	c.(2104-2106)gtG>gtT	p.V702V		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	702					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GGTCCCAGGTCACATTGGAGG	0.552000													31	2					7.11191e-15	8.85272e-15	0.173368	1	0
TUBA4B	80086	broad.mit.edu	37	2	220136562	220136562	+	RNA	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220136562T>G	ENST00000490341.1	+	0	1032					NR_003063.1																						CCCCACAGGCTTTAAGGTTGA	0.532000													34	101					0	0	0.203993	0	0
RYR3	6263	broad.mit.edu	37	15	33954739	33954739	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:33954739C>A	ENST00000389232.4	+	35	5078	c.5008C>A	c.(5008-5010)Cct>Act	p.P1670T	RYR3_ENST00000415757.3_Missense_Mutation_p.P1670T	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1670	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTTCTCCACCCCTTGCTTTGT	0.572000													33	44					4.39465e-27	6.3778e-27	0.173368	1	0
LRP1B	53353	broad.mit.edu	37	2	141709464	141709464	+	Missense_Mutation	SNP	C	C	A	rs28483746		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:141709464C>A	ENST00000389484.3	-	19	3904	c.2933G>T	c.(2932-2934)gGa>gTa	p.G978V		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	978	LDL-receptor class A 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATGCATCTTCCACTTTTGCA	0.443000										TSP Lung(27;0.18)			48	105					5.82388e-19	7.67513e-19	0.323286	1	0
LRBA	987	broad.mit.edu	37	4	151849697	151849697	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:151849697T>C	ENST00000535741.1	-	4	993	c.520A>G	c.(520-522)Agt>Ggt	p.S174G	LRBA_ENST00000510413.1_Missense_Mutation_p.S174G|LRBA_ENST00000507224.1_Missense_Mutation_p.S174G|LRBA_ENST00000357115.3_Missense_Mutation_p.S174G			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	174						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TGAAGTTTACTGAAGAAAAGC	0.363000													35	4					0	0	0.323286	0	0
FKBPL	63943	broad.mit.edu	37	6	32096983	32096983	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:32096983A>C	ENST00000375156.3	-	2	845	c.575T>G	c.(574-576)tTc>tGc	p.F192C		NM_022110.3	NP_071393.2	Q9UIM3	FKBPL_HUMAN	FK506 binding protein like	192					response to radiation	membrane|nucleus	FK506 binding|peptidyl-prolyl cis-trans isomerase activity										GCCTTGAGTGAAGGATGCCAG	0.567000													51	92					0	0	0.323286	0	0
TBX22	50945	broad.mit.edu	37	X	79286131	79286131	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:79286131G>T	ENST00000442340.1	+	9	1214	c.724G>T	c.(724-726)Gca>Tca	p.A242S	TBX22_ENST00000373291.1_Missense_Mutation_p.A242S|TBX22_ENST00000373294.5_Missense_Mutation_p.A362S|TBX22_ENST00000373296.3_Missense_Mutation_p.A362S	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	362					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						CTGTCCAGAGGCATACCTGCC	0.473000													71	6					1.53134e-21	2.08923e-21	0.323286	1	0
LRRK2	120892	broad.mit.edu	37	12	40758836	40758836	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:40758836G>A	ENST00000298910.7	+	49	7432	c.7374G>A	c.(7372-7374)atG>atA	p.M2458I		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2458					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCAGAGTCATGATGACAGCAC	0.343000													60	42					0	0	0.323286	0	0
CNGA3	1261	broad.mit.edu	37	2	99013354	99013354	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:99013354C>A	ENST00000393504.1	+	8	2138	c.1721C>A	c.(1720-1722)tCa>tAa	p.S574*	CNGA3_ENST00000272602.2_Nonsense_Mutation_p.S574*|CNGA3_ENST00000436404.2_Nonsense_Mutation_p.S556*|CNGA3_ENST00000409937.1_Nonsense_Mutation_p.S578*	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	574					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						ATTGGCTACTCAGACCTGTTC	0.582000													22	46					3.93418e-24	5.54582e-24	0.203993	1	0
ZNF91	7644	broad.mit.edu	37	19	23545398	23545398	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:23545398C>A	ENST00000300619.7	-	4	588	c.383G>T	c.(382-384)aGt>aTt	p.S128I	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.S96I	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	128						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				CTCATCCACACTTTTACAACC	0.348000													114	71					1.99536e-56	3.45038e-56	0.323286	1	0
DIO2	1734	broad.mit.edu	37	14	80669222	80669222	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:80669222A>T	ENST00000557010.1	-	4	1017	c.632T>A	c.(631-633)gTg>gAg	p.V211E	DIO2_ENST00000422005.3_3'UTR|DIO2_ENST00000555750.1_Missense_Mutation_p.V247E|DIO2_ENST00000557125.1_3'UTR|DIO2_ENST00000438257.4_Missense_Mutation_p.V211E	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	211					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		GCGGTCAGCCACAACTCGGCA	0.522000											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	96	121					0	0	0.323286	0	0
OBSCN	84033	broad.mit.edu	37	1	228503557	228503557	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:228503557C>G	ENST00000570156.2	+	61	15967	c.15893C>G	c.(15892-15894)aCg>aGg	p.T5298R	OBSCN_ENST00000366707.4_Missense_Mutation_p.T1975R|OBSCN_ENST00000366709.4_Missense_Mutation_p.T1460R|OBSCN_ENST00000422127.1_Missense_Mutation_p.T4341R|OBSCN_ENST00000284548.11_Missense_Mutation_p.T4341R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4341	Ig-like 50.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCCAAGAACACGGTGGTGCGG	0.657000													28	5					0	0	0.225048	0	0
MYO3A	53904	broad.mit.edu	37	10	26455078	26455078	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:26455078C>G	ENST00000265944.5	+	27	3248	c.3082C>G	c.(3082-3084)Ctc>Gtc	p.L1028V	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1028	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AAAAGCTGGTCTCGATAACTG	0.413000													333	388					0	0	0.323286	0	0
WNK4	65266	broad.mit.edu	37	17	40939379	40939379	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:40939379G>A	ENST00000246914.5	+	7	1581	c.1560G>A	c.(1558-1560)aaG>aaA	p.K520K	WNK4_ENST00000587705.1_3'UTR	NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	520					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TCCAGCGAAAGCGTGAGAAGC	0.622000													23	78					0	0	0.309145	0	0
TTN	7273	broad.mit.edu	37	2	179583275	179583275	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179583275G>A	ENST00000589042.1	-	85	24782	c.24558C>T	c.(24556-24558)agC>agT	p.S8186S	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Silent_p.S7869S|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Silent_p.S6942S	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7869	Ig-like 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAACTATGGGGCTTCCTGTCT	0.428000													33	59					0	0	0.183431	0	0
SLC39A2	29986	broad.mit.edu	37	14	21467673	21467673	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:21467673G>T	ENST00000298681.4	+	1	225	c.68G>T	c.(67-69)gGc>gTc	p.G23V	SLC39A2_ENST00000554422.1_Missense_Mutation_p.G23V	NM_014579.3	NP_055394.2	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter), member 2	23						cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	14	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		CTGGGCTGTGGCCTTACTCCC	0.517000													112	113					1.78676e-68	3.17112e-68	0.323286	1	0
NYAP1	222950	broad.mit.edu	37	7	100085860	100085860	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100085860C>A	ENST00000423930.1	+	4	675	c.516C>A	c.(514-516)ctC>ctA	p.L172L	NYAP1_ENST00000300179.2_Silent_p.L172L|NYAP1_ENST00000454988.1_Silent_p.L115L			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	172																	ACACCCAGCTCTCTGTCTCCT	0.652000													4	93					0.00909568	0.00927843	0.150653	1	0
DSC2	1824	broad.mit.edu	37	18	28672253	28672253	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:28672253T>G	ENST00000280904.6	-	3	608	c.165A>C	c.(163-165)aaA>aaC	p.K55N	DSC2_ENST00000251081.6_Missense_Mutation_p.K55N	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	55					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			TAAAGCACTCTTTCAGGTTAA	0.343000													28	62					0	0	0.116897	0	0
SEC22B	9554	broad.mit.edu	37	1	145116811	145116811	+	RNA	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:145116811C>G	ENST00000453618.1	+	0	1897							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										GTTTGTTTTCCTCTTGCCACA	0.393000													4	24					0	0	0.184627	0	0
OR10H4	126541	broad.mit.edu	37	19	16059890	16059890	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:16059890C>T	ENST00000322107.1	+	1	73	c.73C>T	c.(73-75)Ctg>Ttg	p.L25L		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						CCAGCACCTCCTGCCCATCTT	0.478000													107	206					0	0	0.323286	0	0
LRP1B	53353	broad.mit.edu	37	2	141641395	141641395	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:141641395G>T	ENST00000389484.3	-	25	5131	c.4160C>A	c.(4159-4161)cCa>cAa	p.P1387Q		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1387					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCATATCTTGGGTCCAAAGC	0.378000										TSP Lung(27;0.18)			28	149					1.12875e-08	1.25746e-08	0.116897	1	0
SEL1L2	80343	broad.mit.edu	37	20	13858203	13858203	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:13858203T>A	ENST00000284951.5	-	11	1063	c.989A>T	c.(988-990)aAg>aTg	p.K330M	SEL1L2_ENST00000486903.1_5'UTR|SEL1L2_ENST00000378072.5_Missense_Mutation_p.K330M			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	330						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						ACTCCCGGCCTTTGCTGCCTT	0.353000													34	31					0	0	0.225048	0	0
KCNN2	3781	broad.mit.edu	37	5	113829163	113829163	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:113829163G>T	ENST00000512097.3	+	8	2464	c.1446G>T	c.(1444-1446)ttG>ttT	p.L482F	RP11-492A10.1_ENST00000514115.1_RNA|KCNN2_ENST00000503706.1_Missense_Mutation_p.L134F|KCNN2_ENST00000264773.3_Missense_Mutation_p.L482F|KCNN2_ENST00000507750.1_3'UTR			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	482	Calmodulin-binding (By similarity).					integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		TGGTGGACTTGGCAAAGGTAA	0.418000													54	65					1.53122e-18	2.00515e-18	0.323286	1	0
PLA2G4A	5321	broad.mit.edu	37	1	186925348	186925348	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:186925348G>T	ENST00000367466.3	+	14	1603	c.1451G>T	c.(1450-1452)gGa>gTa	p.G484V	PLA2G4A_ENST00000442353.2_Missense_Mutation_p.G424V	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	484	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	ACCAGAGAAGGACGTGCTGGG	0.428000													117	83					6.34794e-51	1.07488e-50	0.323286	1	0
AMER3	205147	broad.mit.edu	37	2	131520623	131520623	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:131520623C>T	ENST00000423981.1	+	2	1088	c.978C>T	c.(976-978)ggC>ggT	p.G326G	AMER3_ENST00000321420.4_Silent_p.G326G	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		CCCTCCTAGGCCCGTGGCTTT	0.662000													12	41					0	0	0.080935	0	0
ASH1L	55870	broad.mit.edu	37	1	155448223	155448223	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:155448223C>G	ENST00000368346.3	-	3	5077	c.4438G>C	c.(4438-4440)Gag>Cag	p.E1480Q	ASH1L_ENST00000392403.3_Missense_Mutation_p.E1480Q			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	1480					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TGTTTGTGCTCAACCATCCAA	0.522000													23	91					0	0	0.264190	0	0
CHML	1122	broad.mit.edu	37	1	241798502	241798502	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:241798502G>A	ENST00000366553.1	-	1	730	c.567C>T	c.(565-567)caC>caT	p.H189H	OPN3_ENST00000469376.1_Intron|OPN3_ENST00000366554.2_Intron|OPN3_ENST00000331838.5_Intron	NM_001821.3	NP_001812.2	P26374	RAE2_HUMAN	choroideremia-like (Rab escort protein 2)	189					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|ovary(4)|skin(3)|stomach(1)	26	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CTGAAACTGTGTGCATACAAG	0.348000													62	207					0	0	0.323286	0	0
SPEG	10290	broad.mit.edu	37	2	220309869	220309869	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220309869G>T	ENST00000312358.7	+	3	933	c.801G>T	c.(799-801)gcG>gcT	p.A267A	SPEG_ENST00000396698.1_Silent_p.A163A|SPEG_ENST00000396695.2_Intron	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	267					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GAGGACGGGCGCTCTCTATCC	0.617000													4	11					0.00909568	0.00927843	0.150653	1	0
IFT74	80173	broad.mit.edu	37	9	27055706	27055706	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:27055706C>A	ENST00000443698.1	+	17	1604	c.1433C>A	c.(1432-1434)aCa>aAa	p.T478K	IFT74_ENST00000380062.5_Missense_Mutation_p.T478K|IFT74_ENST00000433700.1_Missense_Mutation_p.T478K	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)	478						cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		AAGCAAATGACAACTGATCTG	0.338000													7	86					8.12818e-05	8.55061e-05	0.248553	1	0
NFATC2IP	84901	broad.mit.edu	37	16	28975070	28975070	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:28975070G>T	ENST00000320805.4	+	8	1221	c.1146G>T	c.(1144-1146)atG>atT	p.M382I	RP11-264B17.2_ENST00000569974.1_RNA|NFATC2IP_ENST00000564978.1_Missense_Mutation_p.M103I|NFATC2IP_ENST00000568148.1_Missense_Mutation_p.M90I	NM_032815.3	NP_116204.3	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein	382	Ubiquitin-like.					cytoplasm|nucleus				breast(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(2)	11						AGGAGGCCATGGGACTGTCGG	0.552000													75	9					2.35699e-46	3.91399e-46	0.323286	1	0
CROCC	9696	broad.mit.edu	37	1	17266478	17266478	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:17266478A>T	ENST00000375541.5	+	13	1767	c.1698A>T	c.(1696-1698)ctA>ctT	p.L566L	CROCC_ENST00000467938.1_3'UTR	NM_014675.3	NP_055490.3	Q5TZA2	CROCC_HUMAN	ciliary rootlet coiled-coil, rootletin	566					cell cycle|cell projection organization|centrosome organization|protein localization	actin cytoskeleton|centriole|ciliary rootlet|plasma membrane	kinesin binding|structural molecule activity			breast(3)|central_nervous_system(2)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(1)|lung(20)|ovary(3)|prostate(9)|skin(3)|urinary_tract(1)	62		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000174)|all_lung(284;0.000234)|Renal(390;0.000518)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.63e-06)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(64;0.000163)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		GGCGGGCCCTAGAGGAACAGC	0.701000													17	14					0	0	0.249174	0	0
SPNS3	201305	broad.mit.edu	37	17	4352683	4352683	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:4352683G>T	ENST00000355530.2	+	7	1203		c.e7+1		SPNS3_ENST00000576069.1_Intron|SPNS3_ENST00000333476.2_Splice_Site	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)						lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						ACCCCGACAGGTGAGGGCATC	0.657000													15	24					1.64113e-05	1.74121e-05	0.219247	1	0
LTA4H	4048	broad.mit.edu	37	12	96408740	96408740	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:96408740A>C	ENST00000228740.2	-	12	1238	c.1097T>G	c.(1096-1098)cTt>cGt	p.L366R	LTA4H_ENST00000413268.2_Missense_Mutation_p.L342R|LTA4H_ENST00000552789.1_Missense_Mutation_p.L342R|LTA4H_ENST00000548375.1_5'UTR	NM_000895.2	NP_000886.1	P09960	LKHA4_HUMAN	leukotriene A4 hydrolase	366					hormone biosynthetic process|inflammatory response|leukotriene biosynthetic process|peptide catabolic process|prostanoid metabolic process|proteolysis	cytosol|nucleus	aminopeptidase activity|epoxide hydrolase activity|leukotriene-A4 hydrolase activity|metallopeptidase activity|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(3)|lung(4)|skin(2)|stomach(1)	12						ATCAACCACAAGTTTGGTGAA	0.398000													129	111					0	0	0.323286	0	0
CD300LB	124599	broad.mit.edu	37	17	72522097	72522097	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:72522097G>A	ENST00000392621.1	-	2	275	c.271C>T	c.(271-273)Cgc>Tgc	p.R91C	CD300LB_ENST00000314401.3_Missense_Mutation_p.R91C	NM_174892.2	NP_777552.2	A8K4G0	CLM7_HUMAN	CD300 molecule-like family member b	54	Ig-like V-type.					integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(1)	21						GTATCCCAGCGCACCCCTCGG	0.547000													194	374					0	0	0.323286	0	0
CPAMD8	27151	broad.mit.edu	37	19	17057974	17057974	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:17057974C>A	ENST00000443236.1	-	21	2744	c.2713G>T	c.(2713-2715)Gtg>Ttg	p.V905L		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	858						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TTCTTGGTCACATGGCGTTTG	0.592000													114	352					3.54636e-80	6.367e-80	0.323286	1	0
WNT10A	80326	broad.mit.edu	37	2	219747107	219747107	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:219747107G>T	ENST00000258411.3	+	2	971	c.338G>T	c.(337-339)cGc>cTc	p.R113L		NM_025216.2	NP_079492.2	Q9GZT5	WN10A_HUMAN	wingless-type MMTV integration site family, member 10A	113					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to transforming growth factor beta stimulus|female gonad development|hair follicle morphogenesis|odontogenesis|regulation of odontogenesis of dentine-containing tooth|sebaceous gland development|skin development|tongue development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			breast(1)|cervix(1)|endometrium(2)|lung(6)|skin(2)	12		Renal(207;0.0474)		Epithelial(149;4.26e-07)|all cancers(144;8.8e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTGGAGACTCGCAACAAGATC	0.577000													39	120					8.20599e-20	1.09307e-19	0.301197	1	0
ZDBF2	57683	broad.mit.edu	37	2	207170388	207170388	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:207170388A>T	ENST00000374423.3	+	5	1522	c.1136A>T	c.(1135-1137)cAa>cTa	p.Q379L		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	379							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GATCAGCCCCAAGAGACTGCA	0.408000													18	88					0	0	0.204396	0	0
MS4A7	58475	broad.mit.edu	37	11	60156904	60156904	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:60156904T>C	ENST00000358246.1	+	4	439	c.246T>C	c.(244-246)acT>acC	p.T82T	MS4A14_ENST00000531787.1_Intron|MS4A7_ENST00000534016.1_Silent_p.T82T|MS4A7_ENST00000300184.3_Silent_p.T127T|MS4A7_ENST00000530234.2_Intron	NM_206938.1|NM_206940.1	NP_996821.1|NP_996823.1	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member 7	127						integral to membrane	receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(8)|ovary(1)|skin(1)	20						GTTCTGTTACTGCAGGAGCAG	0.488000													20	58					0	0	0.204396	0	0
ZNF706	51123	broad.mit.edu	37	8	102212294	102212294	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:102212294T>A	ENST00000520347.1	-	3	3123	c.167A>T	c.(166-168)cAg>cTg	p.Q56L	ZNF706_ENST00000519882.1_Missense_Mutation_p.Q56L|ZNF706_ENST00000311212.4_Missense_Mutation_p.Q56L|ZNF706_ENST00000517844.1_Missense_Mutation_p.Q56L|ZNF706_ENST00000518336.1_Missense_Mutation_p.Q56L|ZNF706_ENST00000521272.1_Missense_Mutation_p.Q56L|ZNF706_ENST00000520984.1_Missense_Mutation_p.Q56L|ZNF706_ENST00000519744.1_Intron			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	56						intracellular	zinc ion binding			large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTCAAAGTGCTGCTTGAAGGT	0.363000													39	49					0	0	0.323286	0	0
CNNM1	26507	broad.mit.edu	37	10	101136906	101136906	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:101136906C>A	ENST00000356713.4	+	7	2560	c.2271C>A	c.(2269-2271)taC>taA	p.Y757*	CNNM1_ENST00000370528.3_Nonsense_Mutation_p.Y686*|CNNM1_ENST00000370534.4_Nonsense_Mutation_p.Y413*|CNNM1_ENST00000488090.1_3'UTR|CNNM1_ENST00000446890.1_Nonsense_Mutation_p.Y686*	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	757					ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		CCCAGCTGTACAGCAGCAGCA	0.552000													32	6					3.3946e-10	3.8851e-10	0.225048	1	0
TRAV12-1	28674	broad.mit.edu	37	14	22309869	22309869	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:22309869C>A	ENST00000390433.1	+	0	253																											GTTTACAGCACAGCTCAATAG	0.478000													198	515					2.05961e-90	3.73236e-90	0.323286	1	0
FIGN	55137	broad.mit.edu	37	2	164466754	164466754	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:164466754T>C	ENST00000333129.3	-	3	1902	c.1588A>G	c.(1588-1590)Aca>Gca	p.T530A	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	530						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						GTTTTGCCTGTCCCCCGAGGT	0.507000													63	180					0	0	0.323286	0	0
THSD7A	221981	broad.mit.edu	37	7	11485945	11485945	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:11485945C>A	ENST00000423059.3	-	13	3058	c.2807G>T	c.(2806-2808)aGt>aTt	p.S936I	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	936	TSP type-1 9.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CTTCTTTTTACTTTTTCCTGT	0.343000										HNSCC(18;0.044)			237	235					6.03081e-106	1.10452e-105	0.323286	1	0
LINC01555	439927	broad.mit.edu	37	1	85097365	85097365	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:85097365G>T	ENST00000370624.1	-	2	153	c.26C>A	c.(25-27)aCt>aAt	p.T9N	C1orf180_ENST00000327308.3_Missense_Mutation_p.T9N																							CACAACTACAGTCACTTGGGC	0.463000													7	6					1.12685e-05	1.20009e-05	0.307466	1	0
OR4M1	441670	broad.mit.edu	37	14	20248915	20248915	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20248915T>G	ENST00000315957.4	+	1	515	c.434T>G	c.(433-435)gTg>gGg	p.V145G		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGTATCCTGGTGGCTCTCTCC	0.498000													31	804					0	0	0.163468	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532236	40532236	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:40532236C>A	ENST00000297737.6	-	5	710	c.564G>T	c.(562-564)atG>atT	p.M188I	ZMAT4_ENST00000315769.7_Intron	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	188						nucleus	DNA binding|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			TCAGTTCCCCCATATCCAGGG	0.458000													67	127					5.43229e-20	7.26417e-20	0.323286	1	0
ATP13A1	57130	broad.mit.edu	37	19	19770556	19770556	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19770556G>C	ENST00000357324.6	-	3	557	c.531C>G	c.(529-531)atC>atG	p.I177M	ATP13A1_ENST00000291503.5_Missense_Mutation_p.I59M	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	177					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						AGGAATACTTGATCTTCTGGA	0.557000													7	59					0	0	0.248553	0	0
CLDN9	9080	broad.mit.edu	37	16	3063874	3063874	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:3063874G>T	ENST00000445369.2	+	1	1418	c.511G>T	c.(511-513)Gct>Tct	p.A171S		NM_020982.3	NP_066192.1	O95484	CLD9_HUMAN	claudin 9	171					calcium-independent cell-cell adhesion|tight junction assembly	integral to membrane|tight junction	identical protein binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(5)|prostate(2)	10						CTGGGCGGCGGCTGCACTGCT	0.721000													13	0					0.000151284	0.000158769	0.105934	1	0
GATA2	2624	broad.mit.edu	37	3	128200750	128200750	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:128200750C>A	ENST00000341105.2	-	5	1386	c.1055G>T	c.(1054-1056)tGt>tTt	p.C352F	GATA2_ENST00000430265.2_Intron|GATA2_ENST00000489987.1_5'UTR|GATA2_ENST00000487848.1_Missense_Mutation_p.C352F	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	352					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		TGTCGTCTGACAATTTGCACA	0.637000			Mis		AML(CML blast transformation)								7	26					2.80697e-09	3.15772e-09	0.080935	1	0
ALB	213	broad.mit.edu	37	4	74280832	74280832	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:74280832C>A	ENST00000295897.4	+	9	1228	c.1139C>A	c.(1138-1140)aCt>aAt	p.T380N	ALB_ENST00000401494.3_Missense_Mutation_p.T265N|ALB_ENST00000415165.2_Missense_Mutation_p.T188N|ALB_ENST00000509063.1_Missense_Mutation_p.T380N|ALB_ENST00000503124.1_Missense_Mutation_p.T230N|ALB_ENST00000505649.1_3'UTR	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	380	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	TATGAAACCACTCTAGAGAAG	0.393000													42	20					4.49093e-37	7.11792e-37	0.323286	1	0
OR13G1	441933	broad.mit.edu	37	1	247835874	247835874	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247835874G>C	ENST00000359688.2	-	1	491	c.470C>G	c.(469-471)aCa>aGa	p.T157R	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GATAAGAGCTGTGTGCACCCA	0.468000													54	161					0	0	0.323286	0	0
ATP2A3	489	broad.mit.edu	37	17	3850917	3850917	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:3850917C>A	ENST00000309890.7	-	8	1013	c.863G>T	c.(862-864)tGg>tTg	p.W288L	ATP2A3_ENST00000352011.3_Missense_Mutation_p.W288L|ATP2A3_ENST00000397041.3_Missense_Mutation_p.W288L|ATP2A3_ENST00000397043.3_Missense_Mutation_p.W288L|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397035.3_Missense_Mutation_p.W288L|ATP2A3_ENST00000359983.3_Missense_Mutation_p.W288L	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	288					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GCCACGCAGCCAGGAGCCACC	0.662000													8	13					7.48243e-07	8.1252e-07	0.058154	1	0
WWC3	55841	broad.mit.edu	37	X	10085242	10085242	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:10085242C>T	ENST00000380861.4	+	11	1534	c.1143C>T	c.(1141-1143)tcC>tcT	p.S381S	WWC3_ENST00000454666.1_Silent_p.S381S	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	381	Ser-rich.									NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						CTCTGGCCTCCAGCCGGGGCT	0.667000													25	16					0	0	0.144211	0	0
DTHD1	401124	broad.mit.edu	37	4	36296478	36296478	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:36296478C>A	ENST00000456874.2	+	4	1143	c.1085C>A	c.(1084-1086)tCa>tAa	p.S362*	DTHD1_ENST00000357504.3_Nonsense_Mutation_p.S197*|DTHD1_ENST00000507598.1_Nonsense_Mutation_p.S402*	NM_001170700.1	NP_001164171.1	Q6ZMT9	DTHD1_HUMAN	death domain containing 1	362					signal transduction					breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|stomach(1)	8						ACTTTCTACTCAGTCCAATCC	0.373000													30	29					1.38854e-25	1.98537e-25	0.134883	1	0
OR7C1	26664	broad.mit.edu	37	19	14910548	14910548	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:14910548A>C	ENST00000248073.2	-	1	475	c.401T>G	c.(400-402)gTc>gGc	p.V134G	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	134					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						GTTCATGATGACCGTATAGTG	0.522000													49	117					0	0	0.323286	0	0
ATRNL1	26033	broad.mit.edu	37	10	117309038	117309038	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:117309038C>A	ENST00000355044.3	+	26	3913	c.3787C>A	c.(3787-3789)Cgg>Agg	p.R1263R	ATRNL1_ENST00000303745.7_Silent_p.R56R|ATRNL1_ENST00000423111.2_Silent_p.R314R	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1263						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GGCTTCTCGACGGAGAGAGGT	0.343000													20	2					1.96292e-10	2.25656e-10	0.219247	1	0
TPBG	7162	broad.mit.edu	37	6	83075627	83075627	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:83075627G>T	ENST00000369750.3	+	2	1566	c.949G>T	c.(949-951)Ggc>Tgc	p.G317C	TPBG_ENST00000543496.1_Missense_Mutation_p.G317C|TPBG_ENST00000535040.1_Missense_Mutation_p.G317C			Q13641	TPBG_HUMAN	trophoblast glycoprotein	317	LRRCT.				cell adhesion	integral to plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		GGTAGTGCAGGGCAAAGACCG	0.542000													79	40					3.37217e-29	4.99694e-29	0.323286	1	0
DLG4	1742	broad.mit.edu	37	17	7107081	7107081	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:7107081C>T	ENST00000399510.2	-	7	1246	c.394G>A	c.(394-396)Ggt>Agt	p.G132S	DLG4_ENST00000302955.6_Missense_Mutation_p.G86S|DLG4_ENST00000399506.2_Missense_Mutation_p.G89S|DLG4_ENST00000485100.1_Missense_Mutation_p.G86S	NM_001365.3	NP_001356.1	P78352	DLG4_HUMAN	discs, large homolog 4 (Drosophila)	89	PDZ 1.				axon guidance|learning|protein complex assembly|protein localization to synapse|signal transduction|synaptic transmission	cell junction|cortical cytoskeleton|endocytic vesicle membrane|neuron spine|postsynaptic density|postsynaptic membrane|synaptosome	protein binding|protein C-terminus binding	p.G132S(1)		breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)	18						GGGTCGTCACCGATGTGTGGG	0.602000													20	31					0	0	0.264190	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203776	140203776	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140203776C>A	ENST00000378126.3	+	1	2416	c.2416C>A	c.(2416-2418)Cac>Aac	p.H806N	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_031501.1	NP_113689.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTCACATTCACCCACTTTT	0.328000													13	15					0.0285812	0.0290788	0.146539	1	0
AWAT2	158835	broad.mit.edu	37	X	69264267	69264267	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:69264267G>T	ENST00000276101.3	-	2	136	c.131C>A	c.(130-132)cCa>cAa	p.P44Q		NM_001002254.1	NP_001002254.1	Q6E213	AWAT2_HUMAN	acyl-CoA wax alcohol acyltransferase 2	44						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			endometrium(3)|large_intestine(3)|lung(2)|ovary(1)	9						AGGCCAGTATGGTGTGAACAC	0.522000													36	28					3.86361e-14	4.76147e-14	0.323286	1	0
PALMD	54873	broad.mit.edu	37	1	100155365	100155365	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:100155365G>T	ENST00000263174.4	+	7	1924	c.1549G>T	c.(1549-1551)Gtc>Ttc	p.V517F	PALMD_ENST00000605497.1_Missense_Mutation_p.V517F	NM_017734.4	NP_060204.1	Q9NP74	PALMD_HUMAN	palmdelphin	517					regulation of cell shape	cytoplasm|membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(6)|pancreas(1)|prostate(2)	31		all_epithelial(167;0.000813)|all_lung(203;0.0214)|Lung NSC(277;0.0216)		Epithelial(280;0.067)|all cancers(265;0.117)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)		AGGCAGCCCTGTCCACCATTC	0.428000													60	144					1.13205e-32	1.73906e-32	0.323286	1	0
FAS	355	broad.mit.edu	37	10	90774097	90774097	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:90774097A>G	ENST00000355740.2	+	9	1118	c.898A>G	c.(898-900)Aaa>Gaa	p.K300E	FAS_ENST00000355279.2_3'UTR|FAS_ENST00000352159.4_3'UTR|FAS_ENST00000357339.2_Missense_Mutation_p.K279E	NM_000043.4|NM_152871.2|NM_152872.2	NP_000034.1|NP_690610.1|NP_690611.1	P25445	TNR6_HUMAN	Fas cell surface death receptor	300	Death.|Interaction with HIPK3 (By similarity).				activation of caspase activity|activation of pro-apoptotic gene products|anti-apoptosis|cellular response to mechanical stimulus|positive regulation of necrotic cell death	cytosol|extracellular region|integral to membrane|soluble fraction	identical protein binding|kinase binding			breast(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0161)		Colorectal(12;0.000136)|COAD - Colon adenocarcinoma(12;0.000193)		AGATCTCAAAAAAGCCAATCT	0.363000													101	16					0	0	0.323286	0	0
RAI14	26064	broad.mit.edu	37	5	34796102	34796102	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:34796102G>T	ENST00000265109.3	+	4	513	c.226G>T	c.(226-228)Ggt>Tgt	p.G76C	RAI14_ENST00000397449.1_Missense_Mutation_p.G69C|RAI14_ENST00000507276.1_3'UTR|RAI14_ENST00000512629.1_Missense_Mutation_p.G76C|RAI14_ENST00000428746.2_Missense_Mutation_p.G76C|RAI14_ENST00000503673.1_Missense_Mutation_p.G76C|RAI14_ENST00000515799.1_Missense_Mutation_p.G79C|RAI14_ENST00000506376.1_Missense_Mutation_p.G68C	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14	76						cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					GATTACACATGGTGTGGATGT	0.428000													181	164					3.44484e-87	6.22443e-87	0.323286	1	0
KCNJ2	3759	broad.mit.edu	37	17	68171862	68171862	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:68171862C>A	ENST00000243457.3	+	2	1065	c.682C>A	c.(682-684)Cga>Aga	p.R228R	KCNJ2_ENST00000535240.1_Silent_p.R228R	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	228					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					AGCTCATGTTCGAGCACAGCT	0.473000													65	46					9.65139e-37	1.5258e-36	0.323286	1	0
ELF2	1998	broad.mit.edu	37	4	140046387	140046387	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:140046387C>G	ENST00000394235.2	-	4	671	c.169G>C	c.(169-171)Gat>Cat	p.D57H	ELF2_ENST00000379550.1_Missense_Mutation_p.D57H|ELF2_ENST00000265495.4_Missense_Mutation_p.D57H	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	57					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					GTCTCATCATCATAAACCAGA	0.408000													13	49					0	0	0.105934	0	0
CXCR5	643	broad.mit.edu	37	11	118764713	118764713	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:118764713G>A	ENST00000292174.4	+	2	636	c.460G>A	c.(460-462)Gcc>Acc	p.A154T	BCL9L_ENST00000334801.3_3'UTR	NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	154					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CATTGTCCACGCCGTCCATGC	0.602000													9	35					0	0	0.069234	0	0
DPYSL5	56896	broad.mit.edu	37	2	27165429	27165429	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:27165429G>T	ENST00000288699.6	+	11	1409	c.1251G>T	c.(1249-1251)acG>acT	p.T417T	DPYSL5_ENST00000401478.1_Silent_p.T417T	NM_001253724.1|NM_020134.3	NP_001240653.1|NP_064519.2	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	417					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			breast(1)|endometrium(5)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGCCAGCACGCAGGTCCAGG	0.617000											OREG0014510	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	22					4.87955e-14	5.98731e-14	0.324025	1	0
SORCS1	114815	broad.mit.edu	37	10	108371772	108371772	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:108371772C>A	ENST00000263054.6	-	22	2937	c.2930G>T	c.(2929-2931)cGg>cTg	p.R977L	SORCS1_ENST00000478809.2_5'UTR|SORCS1_ENST00000369698.1_Missense_Mutation_p.R512L|SORCS1_ENST00000344440.6_Missense_Mutation_p.R977L	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	977						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		GCGAAGAGACCGGAATTCCTC	0.443000													71	4					1.15098e-32	1.76727e-32	0.323286	1	0
DNAH11	8701	broad.mit.edu	37	7	21826313	21826313	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:21826313G>T	ENST00000328843.6	+	60	9721	c.9690G>T	c.(9688-9690)atG>atT	p.M3230I	DNAH11_ENST00000409508.3_Missense_Mutation_p.M3223I			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3230	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CAGCCGTGATGGTCCTTCTGG	0.507000									Kartagener syndrome				30	363					8.73648e-17	1.11621e-16	0.203993	1	0
SPAG6	9576	broad.mit.edu	37	10	22676834	22676834	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:22676834C>A	ENST00000376603.2	+	6	1131	c.989C>A	c.(988-990)cCa>cAa	p.P330Q	SPAG6_ENST00000538630.1_Missense_Mutation_p.P229Q|SPAG6_ENST00000376601.1_Intron|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000313311.6_Missense_Mutation_p.P254Q|SPAG6_ENST00000376624.3_Missense_Mutation_p.P254Q			O75602	SPAG6_HUMAN	sperm associated antigen 6	254					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						GAGATTTTTCCAGTTGTACTT	0.388000													26	72					2.48779e-11	2.92066e-11	0.324025	1	0
OR2Y1	134083	broad.mit.edu	37	5	180166886	180166886	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:180166886G>T	ENST00000307832.2	-	1	213	c.173C>A	c.(172-174)cCt>cAt	p.P58H		NM_001001657.1	NP_001001657.1	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y, member 1	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAAGTACATAGGTGTGTGCAG	0.522000													52	84					2.47907e-22	3.426e-22	0.323286	1	0
DAK	26007	broad.mit.edu	37	11	61106796	61106796	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:61106796C>A	ENST00000394900.3	+	5	604	c.375C>A	c.(373-375)gcC>gcA	p.A125A		NM_015533.3	NP_056348.2	Q3LXA3	DHAK_HUMAN	dihydroxyacetone kinase 2 homolog (S. cerevisiae)	125	DhaK.				glycerol metabolic process	cytosol	ATP binding|FAD-AMP lyase (cyclizing) activity|glycerone kinase activity|metal ion binding			NS(1)|breast(3)|endometrium(3)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	23						GGGAGCAGGCCCGGGCTGAAG	0.667000													15	51					1.01871e-10	1.17942e-10	0.204396	1	0
HERC1	8925	broad.mit.edu	37	15	64067665	64067665	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:64067665T>A	ENST00000443617.2	-	2	245	c.158A>T	c.(157-159)cAa>cTa	p.Q53L		NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	53					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						GCATAAAACTTGTTGGGGCAA	0.443000													45	63					0	0	0.323286	0	0
MYH15	22989	broad.mit.edu	37	3	108135677	108135677	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:108135677C>T	ENST00000273353.3	-	30	4046	c.3990G>A	c.(3988-3990)caG>caA	p.Q1330Q		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1330						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						CCTTTTCCAGCTGCCCTCTCA	0.413000													28	58					0	0	0.309145	0	0
HOXA2	3199	broad.mit.edu	37	7	27141938	27141938	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:27141938G>T	ENST00000222718.5	-	1	492	c.182C>A	c.(181-183)cCc>cAc	p.P61H		NM_006735.3	NP_006726.1	O43364	HXA2_HUMAN	homeobox A2	61						nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|cervix(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	22						GTGACTGCCGGGGTTCAGGCT	0.667000													12	17					2.32078e-09	2.61839e-09	0.132662	1	0
GRM7	2917	broad.mit.edu	37	3	6903105	6903105	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:6903105C>A	ENST00000486284.1	+	1	304	c.30C>A	c.(28-30)gtC>gtA	p.V10V	GRM7_ENST00000389336.4_Silent_p.V10V|GRM7_ENST00000357716.4_Silent_p.V10V|GRM7_ENST00000403881.1_Silent_p.V10V|GRM7_ENST00000402647.2_Silent_p.V10V	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	10					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	TGCTCCGCGTCCTGACTTTGA	0.716000													5	17					2.0095e-06	2.16919e-06	0.248553	1	0
TINAGL1	64129	broad.mit.edu	37	1	32042825	32042825	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:32042825C>T	ENST00000271064.7	+	2	152	c.76C>T	c.(76-78)Cgt>Tgt	p.R26C	TINAGL1_ENST00000441210.2_Missense_Mutation_p.R26C|TINAGL1_ENST00000457433.2_Missense_Mutation_p.R26C|TINAGL1_ENST00000537531.1_Missense_Mutation_p.R26C|TINAGL1_ENST00000481165.1_3'UTR	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	26					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		CCAGCAGGGTCGTGGGCGCCG	0.726000													10	21					0	0	0.058154	0	0
HCK	3055	broad.mit.edu	37	20	30662476	30662476	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:30662476A>T	ENST00000534862.1	+	6	683	c.320A>T	c.(319-321)tAc>tTc	p.Y107F	HCK_ENST00000518730.1_Missense_Mutation_p.Y105F|HCK_ENST00000520553.1_Missense_Mutation_p.Y106F|HCK_ENST00000375862.2_Missense_Mutation_p.Y126F|HCK_ENST00000375852.2_Missense_Mutation_p.Y127F|HCK_ENST00000538448.1_Missense_Mutation_p.Y106F	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	127	SH3.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AAGGAGGGCTACATCCCAAGC	0.547000													78	70					0	0	0.323286	0	0
AHNAK2	113146	broad.mit.edu	37	14	105412494	105412494	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:105412494C>A	ENST00000333244.5	-	7	9413	c.9294G>T	c.(9292-9294)acG>acT	p.T3098T	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3098						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CGTCGGGGGCCGTCACGTCCG	0.627000													23	44					2.4375e-19	3.2288e-19	0.125774	1	0
TMEM163	81615	broad.mit.edu	37	2	135215631	135215631	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:135215631C>G	ENST00000281924.6	-	7	845	c.781G>C	c.(781-783)Ggc>Cgc	p.G261R		NM_030923.4	NP_112185.1	Q8TC26	TM163_HUMAN	transmembrane protein 163	261						integral to membrane				endometrium(1)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(221;0.154)		ATGGTGAGGCCGATCAGAACG	0.562000													6	530					0	0	0.248553	0	0
KLRG1	10219	broad.mit.edu	37	12	9147751	9147751	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:9147751G>T	ENST00000266551.4	+	3	239	c.224G>T	c.(223-225)tGc>tTc	p.C75F	KLRG1_ENST00000538029.1_Intron|KLRG1_ENST00000356986.3_Missense_Mutation_p.C75F|RP11-259O18.4_ENST00000545706.1_RNA	NM_005810.3	NP_005801.3	Q96E93	KLRG1_HUMAN	killer cell lectin-like receptor subfamily G, member 1	75					cell surface receptor linked signaling pathway|cellular defense response|inflammatory response|regulation of immune response	integral to membrane	receptor activity|sugar binding			breast(1)|central_nervous_system(1)|kidney(1)|lung(3)|pancreas(1)|upper_aerodigestive_tract(1)	8						TGTCCTAGCTGCCCAGACCGC	0.468000													31	65					3.11337e-16	3.95169e-16	0.173368	1	0
ASMTL	8623	broad.mit.edu	37	X	1554611	1554611	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:1554611T>A	ENST00000534940.1	-	4	365	c.140A>T	c.(139-141)cAg>cTg	p.Q47L	ASMTL_ENST00000416733.2_Intron|ASMTL_ENST00000381333.4_Missense_Mutation_p.Q89L|ASMTL_ENST00000381317.3_Missense_Mutation_p.Q105L	NM_001173473.1	NP_001166944.1	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	105	MAF-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(9)|pancreas(1)|soft_tissue(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTAGGCGTCCTGCTTGTCCAC	0.612000													11	16					0	0	0.146539	0	0
KIF13B	23303	broad.mit.edu	37	8	28981541	28981541	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:28981541C>A	ENST00000524189.1	-	27	3390	c.3352_splice	c.e27+1	p.D1118_splice	CTD-2647L4.1_ENST00000523661.1_RNA	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1118					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		TTTTTCCTACCACGTTTACTG	0.358000													17	22					1.02788e-11	1.21409e-11	0.160694	1	0
PCDHB5	26167	broad.mit.edu	37	5	140515358	140515358	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140515358G>C	ENST00000231134.5	+	1	559	c.342G>C	c.(340-342)gtG>gtC	p.V114V		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		114	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAATCCAGTGCAGTTTTTTC	0.463000													69	58					0	0	0.323286	0	0
FAM114A2	10827	broad.mit.edu	37	5	153405995	153405995	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:153405995C>A	ENST00000351797.4	-	8	953	c.877G>T	c.(877-879)Gca>Tca	p.A293S	FAM114A2_ENST00000520667.1_Missense_Mutation_p.A293S|FAM114A2_ENST00000520313.1_Missense_Mutation_p.A223S|FAM114A2_ENST00000522858.1_Missense_Mutation_p.A293S	NM_018691.2	NP_061161.2	Q9NRY5	F1142_HUMAN	family with sequence similarity 114, member A2	293							purine nucleotide binding			NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|skin(1)|urinary_tract(1)	18						CAAAATTCTGCTAGAGAAAAT	0.358000													20	27					1.28384e-07	1.40646e-07	0.234183	1	0
CCDC151	115948	broad.mit.edu	37	19	11541569	11541569	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:11541569T>A	ENST00000356392.4	-	3	481	c.394A>T	c.(394-396)Att>Ttt	p.I132F	CCDC151_ENST00000591179.1_Intron|CCDC151_ENST00000545100.1_Missense_Mutation_p.I78F|CCDC151_ENST00000586836.1_5'UTR	NM_145045.4	NP_659482.3	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	132										endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	12						CATTCGCGAATCACTGCCTGG	0.577000													75	5					0	0	0.323286	0	0
COL22A1	169044	broad.mit.edu	37	8	139629199	139629199	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:139629199G>A	ENST00000303045.6	-	54	4274	c.3828C>T	c.(3826-3828)ggC>ggT	p.G1276G	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Silent_p.G1256G	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1276	Collagen-like 12.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GTCCCTTGAAGCCCTAGAAGG	0.602000										HNSCC(7;0.00092)			20	36					0	0	0.219247	0	0
PKD1L2	114780	broad.mit.edu	37	16	81171045	81171045	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:81171045G>T	ENST00000525539.1	-	0	5715				PKD1L2_ENST00000533478.1_RNA	NM_052892.3	NP_443124.3	Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2						neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ACATTACCTGGGCCCAACAGA	0.612000													10	19					0.0809354	0.0820481	0.080935	1	0
FBN2	2201	broad.mit.edu	37	5	127744489	127744489	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:127744489A>T	ENST00000508053.1	-	14	1930	c.956T>A	c.(955-957)aTt>aAt	p.I319N	FBN2_ENST00000262464.4_Missense_Mutation_p.I319N|FBN2_ENST00000508989.1_Missense_Mutation_p.I286N			P35556	FBN2_HUMAN	fibrillin 2	319	EGF-like 5; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCACTCATCAATGTCTAATCA	0.378000													76	104					0	0	0.323286	0	0
ELOVL4	6785	broad.mit.edu	37	6	80626596	80626596	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:80626596T>C	ENST00000369816.4	-	6	974	c.674A>G	c.(673-675)cAa>cGa	p.Q225R		NM_022726.3	NP_073563.1	Q9GZR5	ELOV4_HUMAN	ELOVL fatty acid elongase 4	225					fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	CACATGGAATTGAATCTGAAA	0.423000													38	69					0	0	0.268233	0	0
COL12A1	1303	broad.mit.edu	37	6	75898087	75898087	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:75898087C>T	ENST00000322507.8	-	8	1297	c.988G>A	c.(988-990)Gga>Aga	p.G330R	COL12A1_ENST00000483888.2_Missense_Mutation_p.G330R|COL12A1_ENST00000416123.2_Missense_Mutation_p.G330R|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	330					cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CCTTCTTCTCCACTAACCAAT	0.368000													143	93					0	0	0.323286	0	0
FAM86DP	692099	broad.mit.edu	37	3	75476998	75476998	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:75476998C>A	ENST00000459803.1	-	0	440					NR_024241.1																						TGTGACCAGGCCTGTGGTACC	0.592000													21	45					7.4402e-23	1.03514e-22	0.294199	1	0
HIBCH	26275	broad.mit.edu	37	2	191155147	191155147	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:191155147C>A	ENST00000392332.3	-	5	508	c.369G>T	c.(367-369)atG>atT	p.M123I	HIBCH_ENST00000359678.5_Missense_Mutation_p.M123I			Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-CoA hydrolase	123					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding			NS(1)|breast(2)|endometrium(1)|large_intestine(1)|lung(5)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			CATTATTCAGCATATATTCTT	0.333000													9	58					0.000978159	0.00101282	0.080935	1	0
C7orf66	154907	broad.mit.edu	37	7	108524515	108524515	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:108524515C>A	ENST00000379007.2	-	1	129	c.75G>T	c.(73-75)tgG>tgT	p.W25C		NM_001024607.1	NP_001019778.1	A4D0T2	CG066_HUMAN	chromosome 7 open reading frame 66	25						integral to membrane				breast(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	15						AACTGAGGCTCCAAAGTCTCT	0.383000													62	186					9.13743e-30	1.36051e-29	0.323286	1	0
RFX2	5990	broad.mit.edu	37	19	6026250	6026250	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:6026250T>A	ENST00000303657.5	-	6	672		c.e6-2		RFX2_ENST00000359161.3_Splice_Site|RFX2_ENST00000592546.1_Intron	NM_000635.3	NP_000626.2	P48378	RFX2_HUMAN	regulatory factor X, 2 (influences HLA class II expression)						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						CATTTCAAGCTAAAGAAAATG	0.358000													46	41					0	0	0.323286	0	0
SCN4A	6329	broad.mit.edu	37	17	62034576	62034576	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:62034576G>A	ENST00000435607.1	-	13	2398	c.2322C>T	c.(2320-2322)ggC>ggT	p.G774G	SCN4A_ENST00000578147.1_Silent_p.G774G	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	774					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	ACATGGCTTGGCCGGCCACCT	0.607000													7	50					0	0	0.093190	0	0
TMEM177	80775	broad.mit.edu	37	2	120438500	120438500	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:120438500G>A	ENST00000424086.1	+	2	544	c.71G>A	c.(70-72)tGt>tAt	p.C24Y	TMEM177_ENST00000496203.1_Intron|TMEM177_ENST00000401466.1_Missense_Mutation_p.C24Y|TMEM177_ENST00000409951.1_Missense_Mutation_p.C24Y|TMEM177_ENST00000272521.6_Missense_Mutation_p.C24Y	NM_001105198.1	NP_001098668.1	Q53S58	TM177_HUMAN	transmembrane protein 177	24						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	13	Colorectal(110;0.196)					GTGGGTTCCTGTGCAGGCCTG	0.607000													32	122					0	0	0.323286	0	0
OR2G3	81469	broad.mit.edu	37	1	247769059	247769059	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247769059C>A	ENST00000320002.2	+	1	204	c.172C>A	c.(172-174)Cca>Aca	p.P58T	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TCTTCATACCCCAATGTACTT	0.433000													110	449					2.90702e-44	4.7863e-44	0.323286	1	0
E2F8	79733	broad.mit.edu	37	11	19261656	19261656	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:19261656T>C	ENST00000527884.1	-	2	245	c.13A>G	c.(13-15)Aag>Gag	p.K5E	RP11-428C19.4_ENST00000527978.1_RNA|E2F8_ENST00000250024.4_Missense_Mutation_p.K5E	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	5					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TAAAGTACCTTTTCGTTCTCC	0.318000													7	57					0	0	0.278610	0	0
FGD3	89846	broad.mit.edu	37	9	95795119	95795119	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:95795119T>C	ENST00000375482.3	+	16	2245	c.1749T>C	c.(1747-1749)tgT>tgC	p.C583C	FGD3_ENST00000337352.6_Silent_p.C583C|FGD3_ENST00000538555.1_Silent_p.C186C|FGD3_ENST00000416701.2_Silent_p.C583C	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	583					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						GCAGAGATTGTTTCCTGACAC	0.632000													21	22					0	0	0.290176	0	0
OSR2	116039	broad.mit.edu	37	8	99961477	99961477	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:99961477G>T	ENST00000297565.4	+	2	793	c.297G>T	c.(295-297)caG>caT	p.Q99H	OSR2_ENST00000522510.1_Missense_Mutation_p.Q99H|OSR2_ENST00000523368.1_Missense_Mutation_p.Q99H|OSR2_ENST00000457907.2_Missense_Mutation_p.Q220H|OSR2_ENST00000435298.2_Missense_Mutation_p.Q99H	NM_001142462.1	NP_001135934.1	Q8N2R0	OSR2_HUMAN	odd-skipped related transciption factor 2	99					bone morphogenesis|chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|eyelid development in camera-type eye|head development|mesonephros development|metanephros development|middle ear morphogenesis|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|osteoblast proliferation|palate development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Breast(36;4.14e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.0136)			ACCCCAAGCAGGGGGCCATTG	0.657000													63	79					2.72615e-36	4.29883e-36	0.323286	1	0
LRRC37A6P	387646	broad.mit.edu	37	10	27538455	27538455	+	RNA	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:27538455G>A	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							AACCTGGTCTGGATGTGGAAG	0.483000													100	373					0	0	0.323286	0	0
PCDHGB2	56103	broad.mit.edu	37	5	140739827	140739827	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140739827C>A	ENST00000522605.1	+	1	125	c.125C>A	c.(124-126)gCc>gAc	p.A42D	PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018923.2|NM_032096.1	NP_061746.1|NP_115267.1												p.A42V(2)		endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	14			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGAGCTGGCCAAAAACTCG	0.597000											OREG0016857	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	36					2.79863e-10	3.20895e-10	0.309145	1	0
TCTEX1D1	200132	broad.mit.edu	37	1	67241989	67241989	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:67241989C>G	ENST00000282670.2	+	4	367	c.239C>G	c.(238-240)aCc>aGc	p.T80S		NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	80										large_intestine(2)|lung(10)|skin(1)	13						CCTGTGGTCACCGTCAATCAT	0.363000													27	88					0	0	0.134883	0	0
GOLGA5	9950	broad.mit.edu	37	14	93263812	93263812	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:93263812G>A	ENST00000163416.2	+	2	286	c.30G>A	c.(28-30)aaG>aaA	p.K10K	GOLGA5_ENST00000355976.2_Silent_p.K10K	NM_005113.2	NP_005104.2	Q8TBA6	GOGA5_HUMAN	golgin A5	10					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		TTGCTGGAAAGGCAGAAGATC	0.413000			T	RET	papillary thyroid								22	38					0	0	0.279207	0	0
MEGF10	84466	broad.mit.edu	37	5	126770382	126770382	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:126770382G>C	ENST00000274473.6	+	16	2111	c.1844G>C	c.(1843-1845)tGc>tCc	p.C615S	MEGF10_ENST00000503335.2_Missense_Mutation_p.C615S	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	615	Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TTTTCAGTCTGCTCCCCTGGT	0.512000													15	21					0	0	0.160694	0	0
OR9K2	441639	broad.mit.edu	37	12	55524038	55524038	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55524038C>A	ENST00000305377.5	+	1	574	c.486C>A	c.(484-486)tcC>tcA	p.S162S		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						TTCAAATGTCCACACGTCTGT	0.463000													112	70					2.20518e-70	3.92272e-70	0.323286	1	0
SLC2A5	6518	broad.mit.edu	37	1	9117522	9117522	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:9117522A>T	ENST00000377424.4	-	3	457	c.278T>A	c.(277-279)gTg>gAg	p.V93E	SLC2A5_ENST00000535586.1_Intron|SLC2A5_ENST00000377414.3_Missense_Mutation_p.V93E	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	93					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		AAATTTATTCACCAAGGGGCC	0.463000													18	45					0	0	0.189662	0	0
PRKAA1	5562	broad.mit.edu	37	5	40798243	40798243	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:40798243T>C	ENST00000397128.2	-	1	57	c.49A>G	c.(49-51)Aaa>Gaa	p.K17E	PRKAA1_ENST00000354209.3_Missense_Mutation_p.K17E|PRKAA1_ENST00000296800.4_Missense_Mutation_p.K8E	NM_006251.5|NM_206907.3	NP_006242.5|NP_996790.3	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic subunit	17					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	CCGTCGTGTTTCTGCTTCTCG	0.687000													25	18					0	0	0.257332	0	0
VAV3	10451	broad.mit.edu	37	1	108185308	108185308	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:108185308G>T	ENST00000370056.4	-	20	2121	c.1847C>A	c.(1846-1848)cCt>cAt	p.P616H	VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000415432.2_Missense_Mutation_p.P56H|VAV3_ENST00000544443.1_Missense_Mutation_p.P20H|VAV3_ENST00000527011.1_Missense_Mutation_p.P616H	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	616	SH3 1.		P -> S (in dbSNP:rs12410676).		angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		GAGCTGTAAAGGGGGTCCTTC	0.478000													183	119					7.61624e-106	1.39406e-105	0.323286	1	0
CDCP1	64866	broad.mit.edu	37	3	45132961	45132961	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:45132961C>T	ENST00000296129.1	-	7	1831	c.1697G>A	c.(1696-1698)cGg>cAg	p.R566Q		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	566						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TGGCAGGCCCCGGTCCCAGTT	0.597000													22	16					0	0	0.264190	0	0
FLG	2312	broad.mit.edu	37	1	152281913	152281913	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152281913G>A	ENST00000368799.1	-	3	5484	c.5449C>T	c.(5449-5451)Cca>Tca	p.P1817S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1817	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTTGACCCTGGGTGTCCACGA	0.592000									Ichthyosis				333	229					0	0	0.323286	0	0
OR4D5	219875	broad.mit.edu	37	11	123810906	123810906	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:123810906T>C	ENST00000307033.2	+	1	657	c.583T>C	c.(583-585)Tta>Cta	p.L195L		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TACCTTTGTCTTAGAGCTTTT	0.478000													26	288					0	0	0.153744	0	0
CELSR2	1952	broad.mit.edu	37	1	109795318	109795318	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:109795318G>T	ENST00000271332.3	+	1	2678	c.2617G>T	c.(2617-2619)Gtg>Ttg	p.V873L		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	873	Cadherin 7.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		GTCAGGCATCGTGCGAACGCT	0.562000													16	39					2.4624e-09	2.77512e-09	0.204396	1	0
PSG2	5670	broad.mit.edu	37	19	43575872	43575872	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:43575872G>C	ENST00000406487.1	-	4	1042	c.944C>G	c.(943-945)tCg>tGg	p.S315W		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	315	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GACTGTCAACGATGTGGAGCT	0.463000													286	24					0	0	0.323286	0	0
AKAP3	10566	broad.mit.edu	37	12	4735925	4735925	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:4735925A>C	ENST00000545990.2	-	5	2667	c.2143T>G	c.(2143-2145)Tat>Gat	p.Y715D	AKAP3_ENST00000228850.1_Missense_Mutation_p.Y715D	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	715					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						AAGCACTCATATAAACTATCT	0.498000													45	133					0	0	0.312237	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140616274	140616274	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140616274G>T	ENST00000526308.1	+	0	2337					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						TGTGCAGGAGGAGCAGGGCGG	0.662000													40	58					3.68427e-32	5.6291e-32	0.290176	1	0
GABRB3	2562	broad.mit.edu	37	15	26866646	26866646	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:26866646C>G	ENST00000541819.2	-	5	546	c.444G>C	c.(442-444)tgG>tgC	p.W148C	GABRB3_ENST00000545868.1_Missense_Mutation_p.W7C|GABRB3_ENST00000400188.3_Missense_Mutation_p.W21C|GABRB3_ENST00000299267.4_Missense_Mutation_p.W92C|GABRB3_ENST00000311550.5_Missense_Mutation_p.W92C			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	92					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTTTATCTCTCCAATATTGTT	0.443000													35	47					0	0	0.183431	0	0
PSG8	440533	broad.mit.edu	37	19	43268390	43268390	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:43268390G>C	ENST00000404209.4	-	2	204	c.108C>G	c.(106-108)gtC>gtG	p.V36V	PSG8_ENST00000306511.4_Silent_p.V36V|PSG8_ENST00000401467.2_Silent_p.V36V|PSG8_ENST00000406636.3_Intron	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	36	Ig-like V-type.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				CTTCAATCGTGACTTGGGCAG	0.458000													359	171					0	0	0.323286	0	0
ITIH5	80760	broad.mit.edu	37	10	7614297	7614297	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:7614297G>T	ENST00000397145.2	-	12	2202	c.2097C>A	c.(2095-2097)atC>atA	p.I699I	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000256861.6_Intron|ITIH5_ENST00000397146.2_Intron|ITIH5_ENST00000298441.6_Intron|ITIH5_ENST00000446830.2_Intron	NM_001001851.2	NP_001001851.1	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	0					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						ATAGTTCCAGGATGCTGGCAA	0.383000													9	30					0.0809354	0.0820481	0.080935	1	0
WASF3	10810	broad.mit.edu	37	13	27256784	27256784	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:27256784G>T	ENST00000361042.4	+	9	1240	c.1015G>T	c.(1015-1017)Gga>Tga	p.G339*	WASF3_ENST00000335327.5_Nonsense_Mutation_p.G342*			Q9UPY6	WASF3_HUMAN	WAS protein family, member 3	342					actin filament polymerization	cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|pancreas(1)|prostate(2)|skin(2)	22	Colorectal(5;0.000247)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0114)|Epithelial(112;0.046)|OV - Ovarian serous cystadenocarcinoma(117;0.0547)|Lung(94;0.105)|LUSC - Lung squamous cell carcinoma(192;0.155)		CAACCCATCCGGACCACCTCC	0.572000													94	122					1.66795e-42	2.72449e-42	0.323286	1	0
AKNA	80709	broad.mit.edu	37	9	117129925	117129925	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:117129925G>A	ENST00000307564.4	-	6	1787	c.1626C>T	c.(1624-1626)ccC>ccT	p.P542P	AKNA_ENST00000374088.3_Silent_p.P542P|AKNA_ENST00000312033.3_Silent_p.P542P|AKNA_ENST00000374075.5_Silent_p.P461P|AKNA_ENST00000223791.3_Silent_p.P2P	NM_030767.4	NP_110394.3	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	542					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(7)|liver(2)|lung(22)|ovary(4)|stomach(2)	51						ACCCCAGGGTGGGCATGCTGG	0.612000													54	57					0	0	0.323286	0	0
GON4L	54856	broad.mit.edu	37	1	155726844	155726844	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:155726844G>A	ENST00000437809.1	-	27	5544	c.5422C>T	c.(5422-5424)Ctg>Ttg	p.L1808L	GON4L_ENST00000368331.1_Silent_p.L1808L|GON4L_ENST00000271883.5_Silent_p.L1808L			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1808					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					ACATCAGGCAGGGCCACTTCT	0.502000													20	56					0	0	0.234183	0	0
OR4K15	81127	broad.mit.edu	37	14	20444296	20444296	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20444296C>A	ENST00000305051.5	+	1	694	c.619C>A	c.(619-621)Cta>Ata	p.L207I		NM_001005486.1	NP_001005486.1	Q8NH41	OR4KF_HUMAN	olfactory receptor, family 4, subfamily K, member 15	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|ovary(1)|prostate(2)|skin(1)|stomach(1)	39	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;3.58e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGACCTTCCTCTAGTGACCAA	0.423000													190	206					6.71154e-100	1.22485e-99	0.323286	1	0
CMYA5	202333	broad.mit.edu	37	5	79028116	79028116	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:79028116A>T	ENST00000446378.2	+	2	3559	c.3528A>T	c.(3526-3528)tcA>tcT	p.S1176S		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1176						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TACCTGATTCAGTCCCTGCAA	0.423000													74	76					0	0	0.323286	0	0
SMAP2	64744	broad.mit.edu	37	1	40881913	40881913	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:40881913G>T	ENST00000539317.1	+	8	700	c.507G>T	c.(505-507)ccG>ccT	p.P169P		NM_001198980.1	NP_001185909.1	Q8WU79	SMAP2_HUMAN	small ArfGAP2	249	Interaction with clathrin heavy chains (By similarity).				regulation of ARF GTPase activity	cytoplasm|nucleus	ARF GTPase activator activity|zinc ion binding			central_nervous_system(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24	Lung NSC(20;1.56e-05)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.04e-17)			ACCTGTTTCCGGAGCCAGGGA	0.498000													115	294					8.11351e-46	1.343e-45	0.323286	1	0
LIPJ	142910	broad.mit.edu	37	10	90350367	90350367	+	Translation_Start_Site	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:90350367A>T	ENST00000371939.3	+	0	237					NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J						lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		TCTTTTCACAATGATGTATTT	0.303000													7	20					0	0	0.248553	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881944	228881944	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:228881944C>A	ENST00000392056.3	-	7	3672	c.3626G>T	c.(3625-3627)aGt>aTt	p.S1209I	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S1209I	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1209						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GGAGGAGGCACTTTCTCTGCT	0.577000													40	79					3.66854e-30	5.48599e-30	0.257332	1	0
MS4A12	54860	broad.mit.edu	37	11	60264992	60264992	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:60264992A>C	ENST00000016913.4	+	2	258	c.201A>C	c.(199-201)caA>caC	p.Q67H	MS4A12_ENST00000525951.1_3'UTR|MS4A12_ENST00000537076.1_Missense_Mutation_p.Q67H	NM_017716.2	NP_060186.2	Q9NXJ0	M4A12_HUMAN	membrane-spanning 4-domains, subfamily A, member 12	67						integral to membrane	receptor activity			breast(1)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)	17						AACCGGGTCAAGGAAATATAC	0.438000													20	41					0	0	0.219247	0	0
ASTN2	23245	broad.mit.edu	37	9	119737595	119737595	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:119737595C>A	ENST00000313400.4	-	10	1881	c.1781G>T	c.(1780-1782)tGg>tTg	p.W594L	ASTN2_ENST00000361209.2_Missense_Mutation_p.W543L|ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.W590L			O75129	ASTN2_HUMAN	astrotactin 2	594						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GACAGGAAGCCAGAGGCCTTG	0.557000													57	75					1.1362e-29	1.68687e-29	0.323286	1	0
ZBTB10	65986	broad.mit.edu	37	8	81412348	81412348	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:81412348A>T	ENST00000430430.1	+	3	2371	c.1592A>T	c.(1591-1593)tAc>tTc	p.Y531F	ZBTB10_ENST00000455036.3_Missense_Mutation_p.Y531F|ZBTB10_ENST00000426744.2_Missense_Mutation_p.Y531F|ZBTB10_ENST00000379091.4_Missense_Mutation_p.Y239F	NM_001277145.1	NP_001264074.1	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10	531					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(4)	20	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			ATAGAAAACTACCAAATGAAT	0.383000													34	27					0	0	0.183431	0	0
PACS1	55690	broad.mit.edu	37	11	65998365	65998365	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:65998365A>G	ENST00000320580.4	+	13	1613	c.1580A>G	c.(1579-1581)aAc>aGc	p.N527S	PACS1_ENST00000529757.1_Missense_Mutation_p.N63S	NM_018026.3	NP_060496.2	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	527					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding		RBM14/PACS1(2)	breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(8)|ovary(6)|skin(2)|urinary_tract(1)	37						GAGAGGACCAACAGTTCCGAC	0.622000													55	139					0	0	0.323286	0	0
MAS1L	116511	broad.mit.edu	37	6	29455665	29455665	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:29455665T>G	ENST00000377127.3	-	1	73	c.15A>C	c.(13-15)aaA>aaC	p.K5N		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	5						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						ACCAGCAAATTTTCCCCCAGA	0.562000													33	40					0	0	0.214465	0	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													5	70					0	0	0.217242	0	0
LRRTM4	80059	broad.mit.edu	37	2	76975852	76975852	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:76975852G>T	ENST00000409911.1	-	3	1968	c.1745C>A	c.(1744-1746)cCg>cAg	p.P582Q	LRRTM4_ENST00000409884.1_Missense_Mutation_p.P581Q|LRRTM4_ENST00000409093.1_Missense_Mutation_p.P581Q	NM_001134745.1	NP_001128217.1	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	581						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		GTAGATGGCCGGTGCTGCCGA	0.592000													16	109					3.99206e-14	4.91001e-14	0.189662	1	0
AGO1	26523	broad.mit.edu	37	1	36380999	36380999	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:36380999G>T	ENST00000373204.4	+	15	2097	c.1884G>T	c.(1882-1884)cgG>cgT	p.R628R	AGO1_ENST00000373206.1_Silent_p.R553R	NM_012199.2	NP_036331.1			argonaute RISC catalytic component 1																		CTACTGTGCGGGTACAGCGAC	0.527000													87	49					1.31735e-33	2.0389e-33	0.323286	1	0
CSNK2A3	283106	broad.mit.edu	37	11	11373804	11373804	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:11373804T>C	ENST00000528848.2	-	1	1100	c.863A>G	c.(862-864)gAa>gGa	p.E288G	GALNT18_ENST00000227756.4_Intron	NM_001256686.1	NP_001243615.1			casein kinase 2, alpha 3 polypeptide																		GTGCTGATTTTCACTGTGGAC	0.473000													24	157					0	0	0.324025	0	0
TNNT3	7140	broad.mit.edu	37	11	1953717	1953717	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:1953717C>A	ENST00000381558.1	+	8	399	c.120C>A	c.(118-120)atC>atA	p.I40I	TNNT3_ENST00000360603.3_Silent_p.I42I|TNNT3_ENST00000278317.6_Silent_p.I48I|TNNT3_ENST00000381589.3_Silent_p.I46I|TNNT3_ENST00000397301.1_Silent_p.I59I|TNNT3_ENST00000397304.2_Silent_p.I29I|TNNT3_ENST00000381548.3_Silent_p.I50I|TNNT3_ENST00000381549.3_Silent_p.I40I|TNNT3_ENST00000381561.4_Silent_p.I51I|TNNT3_ENST00000446240.1_Silent_p.I29I|TNNT3_ENST00000381579.3_Silent_p.I40I			P45378	TNNT3_HUMAN	troponin T type 3 (skeletal, fast)	59					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(4)|stomach(1)	19		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		CTCCTAAGATCCCAGAAGGGG	0.582000													28	3					9.17885e-22	1.25838e-21	0.183431	1	0
ASMT	438	broad.mit.edu	37	X	1743181	1743181	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:1743181G>A	ENST00000381241.3	+	3	463	c.264G>A	c.(262-264)gaG>gaA	p.E88E	ASMT_ENST00000381233.3_Silent_p.E88E|ASMT_ENST00000381229.4_Silent_p.E88E	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	88					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GAAACACAGAGCTGTCCAGCG	0.562000													104	23					0	0	0.323286	0	0
FAT1	2195	broad.mit.edu	37	4	187541170	187541170	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:187541170C>A	ENST00000441802.2	-	10	6779	c.6570G>T	c.(6568-6570)gaG>gaT	p.E2190D		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2190	Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						TCTCTGCAATCTCTGCACTGT	0.517000										HNSCC(5;0.00058)			90	66					3.05217e-42	4.97504e-42	0.323286	1	0
USH2A	7399	broad.mit.edu	37	1	216052420	216052420	+	Silent	SNP	G	G	T	rs111033506		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:216052420G>T	ENST00000366943.2	-	42	8630	c.8244C>A	c.(8242-8244)ctC>ctA	p.L2748L	USH2A_ENST00000307340.3_Silent_p.L2748L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2748	Fibronectin type-III 14.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CGTTCTGGATGAGTGGGGGTT	0.418000										HNSCC(13;0.011)			52	220					1.04682e-39	1.68678e-39	0.323286	1	0
AIM1L	55057	broad.mit.edu	37	1	26665911	26665911	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:26665911T>A	ENST00000527815.1	-	5	641	c.592A>T	c.(592-594)Acc>Tcc	p.T198S	AIM1L_ENST00000308182.5_Missense_Mutation_p.T27S	NM_001039775.3	NP_001034864.2	Q8N1P7	AIM1L_HUMAN	absent in melanoma 1-like	27	Beta/gamma crystallin 'Greek key' 4.						sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|pancreas(1)|skin(2)	12		all_cancers(24;4.67e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.51e-27)|Colorectal(126;1.61e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000792)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|STAD - Stomach adenocarcinoma(196;0.00154)|GBM - Glioblastoma multiforme(114;0.00858)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.165)|LUSC - Lung squamous cell carcinoma(448;0.239)		ATTTCCGGGGTGCTGTAGTCC	0.562000													25	22					0	0	0.116897	0	0
PEX5L	51555	broad.mit.edu	37	3	179597885	179597885	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:179597885C>A	ENST00000467460.1	-	5	667	c.337G>T	c.(337-339)Gac>Tac	p.D113Y	PEX5L_ENST00000468741.1_5'UTR|PEX5L-AS1_ENST00000466064.1_RNA|PEX5L_ENST00000465751.1_Missense_Mutation_p.D89Y|PEX5L_ENST00000485199.1_Missense_Mutation_p.D78Y|PEX5L_ENST00000476138.1_Missense_Mutation_p.D70Y|PEX5L_ENST00000467440.2_Intron|PEX5L_ENST00000472994.1_Missense_Mutation_p.D54Y|PEX5L_ENST00000464614.1_Intron|PEX5L_ENST00000392649.3_Intron|PEX5L_ENST00000263962.8_Missense_Mutation_p.D111Y	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	113					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TCACTCAGGTCGAGGAGATCT	0.428000													23	50					9.86323e-18	1.27542e-17	0.294199	1	0
C1QC	714	broad.mit.edu	37	1	22970634	22970634	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:22970634G>T	ENST00000374639.3	+	2	236	c.118G>T	c.(118-120)Ggc>Tgc	p.G40C	C1QC_ENST00000374640.4_Missense_Mutation_p.G40C|C1QC_ENST00000374637.1_Missense_Mutation_p.G40C	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	40	Collagen-like.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGGGATGCCCGGCCTGCCCGG	0.692000													8	3					1.33987e-11	1.58139e-11	0.069234	1	0
ABCC11	85320	broad.mit.edu	37	16	48212534	48212534	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:48212534C>A	ENST00000394747.1	-	23	3671	c.3322G>T	c.(3322-3324)Gta>Tta	p.V1108L	ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000356608.2_Missense_Mutation_p.V1108L|ABCC11_ENST00000353782.5_Missense_Mutation_p.V1108L|ABCC11_ENST00000394748.1_Missense_Mutation_p.V1108L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1108						integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				ATCCTCTCTACAGCCGTGAAC	0.577000													19	5					3.73148e-12	4.44305e-12	0.125774	1	0
TFAP2B	7021	broad.mit.edu	37	6	50810975	50810975	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:50810975A>T	ENST00000263046.4	+	8	1446	c.1280A>T	c.(1279-1281)cAg>cTg	p.Q427L	TFAP2B_ENST00000393655.3_Missense_Mutation_p.Q418L			Q92481	AP2B_HUMAN	transcription factor AP-2 beta (activating enhancer binding protein 2 beta)	418				QLCKEFTDLLAQDRTPIGNSRPSPILEPGIQSCLTHFSLIT HGFGAPAICAALTALQNYLTEALKGMDKMFLNNTTTNRHTS GEGPGSKTGDKEEKHRK -> GNFVKNLRIYWRRTGHR (in Ref. 1; CAA71047).	nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)	40	Lung NSC(77;0.156)					ACGGCCCTGCAGAACTATCTC	0.607000													40	139					0	0	0.268233	0	0
MAPT	4137	broad.mit.edu	37	17	44039746	44039746	+	Missense_Mutation	SNP	G	G	T	rs143210139		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:44039746G>T	ENST00000344290.5	+	2	365	c.43G>T	c.(43-45)Gct>Tct	p.A15S	MAPT_ENST00000340799.5_Missense_Mutation_p.A15S|MAPT_ENST00000262410.5_Missense_Mutation_p.A15S|MAPT_ENST00000431008.3_Missense_Mutation_p.A15S|MAPT_ENST00000571987.1_Missense_Mutation_p.A15S|MAPT_ENST00000347967.5_5'UTR|MAPT_ENST00000535772.1_Missense_Mutation_p.A15S|MAPT_ENST00000446361.3_Missense_Mutation_p.A15S|MAPT_ENST00000351559.5_Missense_Mutation_p.A15S|MAPT_ENST00000415613.2_Missense_Mutation_p.A15S|MAPT_ENST00000420682.2_Missense_Mutation_p.A15S|MAPT_ENST00000334239.8_Missense_Mutation_p.A15S|MAPT_ENST00000574436.1_Missense_Mutation_p.A15S|MAPT_ENST00000570299.1_3'UTR	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	15					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				GGAAGATCACGCTGGGACGTA	0.562000													31	57					2.47316e-13	2.99897e-13	0.183431	1	0
EIF3E	3646	broad.mit.edu	37	8	109240540	109240540	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:109240540G>A	ENST00000220849.5	-	7	740	c.678C>T	c.(676-678)ccC>ccT	p.P226P	EIF3E_ENST00000519517.1_5'UTR|EIF3E_ENST00000519030.1_Silent_p.P133P	NM_001568.2	NP_001559.1	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3, subunit E	226					negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding		EIF3E/RSPO2(6)	NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			CGCGACCTTTGGGGTGATTGA	0.363000													75	125					0	0	0.323286	0	0
LHX6	26468	broad.mit.edu	37	9	124971944	124971944	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:124971944G>T	ENST00000559895.1	-	6	1337	c.459C>A	c.(457-459)ccC>ccA	p.P153P	LHX6_ENST00000464484.2_Intron|LHX6_ENST00000541397.2_Intron|LHX6_ENST00000373755.2_Silent_p.P340P|LHX6_ENST00000340587.3_Intron|LHX6_ENST00000373754.2_Intron|LHX6_ENST00000482062.1_Silent_p.P27P|LHX6_ENST00000394319.4_Silent_p.P369P	NM_001242335.1	NP_001229264.1	Q9UPM6	LHX6_HUMAN	LIM homeobox 6	340	LIM zinc-binding 2.|Required for interaction with LBD1 (By similarity).				cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)	8						tgaggtggacggggggtgcgg	0.642000													12	4					8.28177e-16	1.04603e-15	0.189662	1	0
TRIM67	440730	broad.mit.edu	37	1	231337128	231337128	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:231337128G>T	ENST00000444294.3	+	5	2257	c.1399G>T	c.(1399-1401)Gtc>Ttc	p.V467F	TRIM67_ENST00000449018.3_Missense_Mutation_p.V405F|TRIM67_ENST00000366653.5_Missense_Mutation_p.V467F|TRIM67_ENST00000366652.2_Missense_Mutation_p.V467F	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	467	COS.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				GATCAAGCGCGTCCAGGTGTC	0.532000													5	29					0.000602214	0.000625229	0.184627	1	0
VWCE	220001	broad.mit.edu	37	11	61035004	61035004	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:61035004G>A	ENST00000335613.5	-	16	2281	c.1895C>T	c.(1894-1896)aCa>aTa	p.T632I	VWCE_ENST00000535710.1_Missense_Mutation_p.T97I	NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	632	VWFC 5.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GATTCTGCCTGTGTAGGTGCA	0.602000													136	72					0	0	0.323286	0	0
ZNF667	63934	broad.mit.edu	37	19	56953401	56953401	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:56953401T>A	ENST00000504904.3	-	7	1682	c.963A>T	c.(961-963)caA>caT	p.Q321H	ZNF667_ENST00000591790.1_3'UTR|ZNF667_ENST00000292069.6_Missense_Mutation_p.Q321H|ZNF667_ENST00000342634.3_Missense_Mutation_p.Q449H			Q5HYK9	ZN667_HUMAN	zinc finger protein 667	321					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	38		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0615)		GGTGACTTCTTTGCTGTAGAC	0.373000													106	5					0	0	0.323286	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962657	73962657	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:73962657C>A	ENST00000373468.1	-	3	2386	c.1735G>T	c.(1735-1737)Gcc>Tcc	p.A579S	KIAA2022_ENST00000055682.5_Missense_Mutation_p.A579S			Q5QGS0	K2022_HUMAN	KIAA2022	579					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GCCAGCTTGGCATATTTGTTG	0.443000													97	78					6.78028e-52	1.1525e-51	0.323286	1	0
MYH1	4619	broad.mit.edu	37	17	10399761	10399761	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:10399761C>A	ENST00000226207.5	-	34	4856	c.4762G>T	c.(4762-4764)Gac>Tac	p.D1588Y	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1588						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						TTCATCTGGTCAATTTCCTCA	0.443000													114	132					1.54771e-57	2.68832e-57	0.323286	1	0
TBC1D8B	54885	broad.mit.edu	37	X	106046140	106046140	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:106046140G>A	ENST00000357242.5	+	1	231	c.57G>A	c.(55-57)atG>atA	p.M19I	TBC1D8B_ENST00000481617.2_Missense_Mutation_p.M19I|TBC1D8B_ENST00000310452.2_Missense_Mutation_p.M19I|TBC1D8B_ENST00000276175.3_Missense_Mutation_p.M19I	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	19						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TGTGGCTGATGGAAAGGTCCA	0.617000													54	8					0	0	0.323286	0	0
BEND5	79656	broad.mit.edu	37	1	49193631	49193631	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:49193631C>A	ENST00000371833.3	-	6	1279	c.1193G>T	c.(1192-1194)tGt>tTt	p.C398F	AGBL4_ENST00000371839.1_Intron|AGBL4_ENST00000371838.1_Intron|BEND5_ENST00000476096.1_5'UTR	NM_024603.2	NP_078879.2	Q7L4P6	BEND5_HUMAN	BEN domain containing 5	398	BEN.									large_intestine(5)|lung(2)|skin(1)	8						GATTTTTTCACAGATGTACTT	0.348000													34	83					1.36615e-20	1.84195e-20	0.173368	1	0
SLC40A1	30061	broad.mit.edu	37	2	190439990	190439990	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:190439990G>A	ENST00000261024.2	-	3	594	c.168C>T	c.(166-168)aaC>aaT	p.N56N	SLC40A1_ENST00000418714.1_5'UTR	NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	56					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			AAAGGAGGCTGTTTCCATAGA	0.473000													143	232					0	0	0.323286	0	0
FAIM2	23017	broad.mit.edu	37	12	50284484	50284484	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:50284484C>A	ENST00000320634.3	-	7	601	c.507G>T	c.(505-507)ctG>ctT	p.L169L	FAIM2_ENST00000550890.1_Silent_p.L123L	NM_012306.3	NP_036438.2	Q9BWQ8	FAIM2_HUMAN	Fas apoptotic inhibitory molecule 2	169					anti-apoptosis|apoptosis	cell junction|integral to membrane|postsynaptic membrane				endometrium(2)|large_intestine(4)|lung(4)|ovary(2)|skin(2)	14						TCAGGAGAATCAGGTTCCAGG	0.587000													76	191					3.12118e-38	4.98263e-38	0.323286	1	0
FLG	2312	broad.mit.edu	37	1	152284537	152284537	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152284537T>C	ENST00000368799.1	-	3	2860	c.2825A>G	c.(2824-2826)cAg>cGg	p.Q942R	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	942	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACTGGATCCCTGGCGCCTGCT	0.562000									Ichthyosis				94	246					0	0	0.323286	0	0
PGD	5226	broad.mit.edu	37	1	10473253	10473253	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:10473253A>T	ENST00000538557.1	+	8	994	c.750A>T	c.(748-750)acA>acT	p.T250T	PGD_ENST00000270776.8_Silent_p.T263T|PGD_ENST00000541529.1_Silent_p.T241T			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	263					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		AGAAGGGCACAGGGAAGTGGA	0.527000													37	11					0	0	0.225048	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885654	88885654	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:88885654G>A	ENST00000319675.3	-	1	642	c.546C>T	c.(544-546)atC>atT	p.I182I		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	182										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						AGGCATCAGGGATCTGGAAAC	0.572000													49	76					0	0	0.323286	0	0
OR1E2	8388	broad.mit.edu	37	17	3336584	3336584	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:3336584G>T	ENST00000248384.1	-	1	551	c.552C>A	c.(550-552)ccC>ccA	p.P184P		NM_003554.1	NP_003545.1	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E, member 2	184					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)	9						AGAAAAAGTGGGGGATCACAT	0.493000													67	65					1.39921e-30	2.10459e-30	0.323286	1	0
CCDC170	80129	broad.mit.edu	37	6	151939225	151939225	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:151939225A>T	ENST00000367290.5	+	11	2201	c.2112A>T	c.(2110-2112)aaA>aaT	p.K704N	CCDC170_ENST00000239374.7_Missense_Mutation_p.K697N			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	697																	CCTGCCTCAAAGATGTGACTA	0.463000													38	85					0	0	0.301197	0	0
OTUD4	54726	broad.mit.edu	37	4	146063380	146063380	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:146063380C>A	ENST00000454497.2	-	18	1732	c.1595G>T	c.(1594-1596)tGg>tTg	p.W532L	OTUD4_ENST00000455611.2_5'UTR|OTUD4_ENST00000447906.2_Missense_Mutation_p.W597L	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	596							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					TTCACTTGGCCAGGCTGGCAC	0.458000													45	119					3.94839e-29	5.83962e-29	0.323286	1	0
SPTA1	6708	broad.mit.edu	37	1	158653253	158653253	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158653253C>A	ENST00000368148.3	-	3	478	c.298G>T	c.(298-300)Gag>Tag	p.E100*	SPTA1_ENST00000368147.3_Nonsense_Mutation_p.E100*	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	100					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTTTGCACCTCTGCTTCAAGG	0.393000													37	110					2.05212e-20	2.76202e-20	0.225048	1	0
CACNA1H	8912	broad.mit.edu	37	16	1245994	1245994	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:1245994G>T	ENST00000348261.5	+	5	862	c.614G>T	c.(613-615)cGg>cTg	p.R205L	CACNA1H_ENST00000565831.1_Missense_Mutation_p.R205L|CACNA1H_ENST00000358590.4_Missense_Mutation_p.R205L	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	205					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CGGGTGCTGCGGCCCCTCCGC	0.657000													8	2					0.307466	0.309766	0.307466	1	0
DENND5B	160518	broad.mit.edu	37	12	31566440	31566440	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:31566440T>G	ENST00000389082.5	-	13	2875	c.2611A>C	c.(2611-2613)Aga>Cga	p.R871R	DENND5B_ENST00000536562.1_Silent_p.R906R|DENND5B_ENST00000306833.6_Silent_p.R906R	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	871	RUN 1.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGAGACAGTCTTATCCACGCC	0.403000													28	5					0	0	0.324025	0	0
IKZF1	10320	broad.mit.edu	37	7	50467763	50467763	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:50467763C>T	ENST00000331340.3	+	8	1153	c.998C>T	c.(997-999)aCg>aTg	p.T333M	IKZF1_ENST00000357364.4_Missense_Mutation_p.T246M|IKZF1_ENST00000438033.1_Missense_Mutation_p.T246M|IKZF1_ENST00000346667.4_Missense_Mutation_p.T103M|IKZF1_ENST00000343574.5_Missense_Mutation_p.T246M|IKZF1_ENST00000439701.1_Missense_Mutation_p.T291M|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000349824.4_Missense_Mutation_p.T190M|IKZF1_ENST00000359197.5_Missense_Mutation_p.T291M	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	333					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				CTGGTGCAGACGCCCCCGGGC	0.657000			"""D,T"""	BCL6	"""ALL, DLBCL"""								4	37					0	0	0.184627	0	0
PSMD1	5707	broad.mit.edu	37	2	231947622	231947622	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:231947622G>T	ENST00000308696.6	+	13	1601	c.1439G>T	c.(1438-1440)gGc>gTc	p.G480V	PSMD1_ENST00000409643.1_Missense_Mutation_p.G480V|PSMD1_ENST00000373635.4_Missense_Mutation_p.G480V	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	480					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	GGCAGTCTGGGCCTTGGTTTG	0.368000													20	31					2.79863e-10	3.20895e-10	0.309145	1	0
OR10K2	391107	broad.mit.edu	37	1	158389908	158389908	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158389908A>G	ENST00000314902.2	-	1	748	c.749T>C	c.(748-750)gTc>gCc	p.V250A		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V250D(1)		NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					GCCATAGTGGACAGTGACAAT	0.438000													21	232					0	0	0.249174	0	0
MAST3	23031	broad.mit.edu	37	19	18255377	18255377	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:18255377G>T	ENST00000262811.5	+	22	2599	c.2599G>T	c.(2599-2601)Ggg>Tgg	p.G867W	AC007192.6_ENST00000600364.1_RNA	NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	867							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						CCGCCGCCTTGGGGGCCCAAG	0.701000													7	22					2.74318e-10	3.14886e-10	0.058154	1	0
MYH8	4626	broad.mit.edu	37	17	10298676	10298676	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:10298676A>T	ENST00000403437.2	-	34	4830	c.4736T>A	c.(4735-4737)aTc>aAc	p.I1579N	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1579					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CTTTTCTGCGATTTTTCTATC	0.418000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				69	12					0	0	0.323286	0	0
GCH1	2643	broad.mit.edu	37	14	55310842	55310842	+	Missense_Mutation	SNP	G	G	C	rs41298440		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:55310842G>C	ENST00000491895.2	-	6	834	c.646C>G	c.(646-648)Cga>Gga	p.R216G	GCH1_ENST00000543643.2_Intron|GCH1_ENST00000536224.2_Intron|GCH1_ENST00000254299.4_5'UTR|GCH1_ENST00000395514.1_Missense_Mutation_p.R216G	NM_000161.2	NP_000152.1	P30793	GCH1_HUMAN	GTP cyclohydrolase 1	216					dopamine biosynthetic process|GTP catabolic process|neuromuscular process controlling posture|nitric oxide biosynthetic process|positive regulation of nitric-oxide synthase activity|protein homooligomerization|response to interferon-gamma|response to lipopolysaccharide|response to pain|response to tumor necrosis factor|tetrahydrobiopterin biosynthetic process|tetrahydrofolate biosynthetic process	cytoplasmic vesicle|cytosol|nuclear membrane|protein complex	GTP binding|GTP cyclohydrolase I activity|protein homodimerization activity|zinc ion binding			endometrium(2)|lung(7)|skin(2)	11						TGTACACCTCGCATTACCATA	0.428000													86	285					0	0	0.323286	0	0
MUC16	94025	broad.mit.edu	37	19	9070919	9070919	+	Silent	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:9070919A>C	ENST00000397910.4	-	3	16730	c.16527T>G	c.(16525-16527)tcT>tcG	p.S5509S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5511	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGCACATAAGAAAAGGCAG	0.498000													98	197					0	0	0.323286	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5239336	5239336	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:5239336T>G	ENST00000274181.7	+	15	2365	c.2227T>G	c.(2227-2229)Tca>Gca	p.S743A		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	743	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						CGGGAATAACTCAGCCTGCAC	0.512000													30	451					0	0	0.203993	0	0
DMD	1756	broad.mit.edu	37	X	31224699	31224699	+	Splice_Site	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:31224699A>T	ENST00000357033.4	-	66	9855	c.9649_splice	c.e66+1	p.Y3217_splice	DMD_ENST00000378723.3_Splice_Site_p.Y149_splice|DMD_ENST00000378680.2_Splice_Site_p.Y149_splice|DMD_ENST00000361471.4_Splice_Site_p.Y149_splice|DMD_ENST00000378707.3_Splice_Site_p.Y757_splice|DMD_ENST00000474231.1_Splice_Site_p.Y757_splice|DMD_ENST00000378702.4_Splice_Site_p.Y149_splice|DMD_ENST00000359836.1_Splice_Site_p.Y757_splice|DMD_ENST00000343523.2_Splice_Site_p.Y757_splice|DMD_ENST00000541735.1_Splice_Site_p.Y757_splice|DMD_ENST00000378677.2_Splice_Site_p.Y3213_splice	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	3217	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CACGACTTACATCTGTACTTG	0.378000													54	3					0	0	0.323286	0	0
PAGE5	90737	broad.mit.edu	37	X	55248301	55248301	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:55248301T>A	ENST00000289619.5	+	3	488	c.243T>A	c.(241-243)gcT>gcA	p.A81A	PAGE5_ENST00000374955.3_Silent_p.A61A|PAGE5_ENST00000374952.1_Intron	NM_130467.3	NP_569734.2	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 (prostate associated)	81										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						GAGCACCTGCTGTTCAAGGTG	0.448000													76	5					0	0	0.323286	0	0
C20orf166-AS1	253868	broad.mit.edu	37	20	61143800	61143800	+	RNA	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:61143800T>A	ENST00000475015.1	-	0	538				C20orf166-AS1_ENST00000412495.1_RNA																							TCAGCTTGTGTGGTGAACTCC	0.672000													36	39					0	0	0.268233	0	0
PCLO	27445	broad.mit.edu	37	7	82584629	82584629	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:82584629T>A	ENST00000423517.2	-	5	5977	c.5640A>T	c.(5638-5640)gtA>gtT	p.V1880V	PCLO_ENST00000333891.8_Silent_p.V1880V	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1811					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AAACTTTTTGTACTTCTATTA	0.368000													163	149					0	0	0.323286	0	0
RYR2	6262	broad.mit.edu	37	1	237947538	237947538	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:237947538G>T	ENST00000366574.2	+	90	12843	c.12526G>T	c.(12526-12528)Gtg>Ttg	p.V4176L	RYR2_ENST00000360064.6_Missense_Mutation_p.V4182L|RYR2_ENST00000542537.1_Missense_Mutation_p.V4160L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4176					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CATATTTGACGTGGTCAACGA	0.502000													81	331					4.41824e-40	7.13043e-40	0.323286	1	0
SUPT5H	6829	broad.mit.edu	37	19	39962317	39962317	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:39962317G>T	ENST00000599117.1	+	21	2264	c.1897G>T	c.(1897-1899)Ggg>Tgg	p.G633W	SUPT5H_ENST00000402194.2_Missense_Mutation_p.G629W|SUPT5H_ENST00000598725.1_Missense_Mutation_p.G633W|SUPT5H_ENST00000432763.2_Missense_Mutation_p.G633W|SUPT5H_ENST00000359191.6_Missense_Mutation_p.G629W			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	633					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GGTGGAGAACGGGGGCATGTT	0.607000													69	10					3.27973e-32	5.02091e-32	0.323286	1	0
OR4E2	26686	broad.mit.edu	37	14	22134197	22134197	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:22134197C>G	ENST00000408935.1	+	1	901	c.901C>G	c.(901-903)Ctc>Gtc	p.L301V		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		CATGAAGCAGCTCAGGCAGAG	0.423000													33	57					0	0	0.193644	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250468	140250468	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140250468C>G	ENST00000398640.2	+	1	1780	c.1780C>G	c.(1780-1782)Cgc>Ggc	p.R594G	PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAAGGTGCGCGCAGTGGA	0.687000													24	48					0	0	0.125774	0	0
MPP4	58538	broad.mit.edu	37	2	202545734	202545734	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:202545734C>A	ENST00000409474.3	-	10	963	c.756G>T	c.(754-756)gaG>gaT	p.E252D	MPP4_ENST00000409143.1_Missense_Mutation_p.E225D|MPP4_ENST00000359962.5_Missense_Mutation_p.E252D|MPP4_ENST00000447335.2_Missense_Mutation_p.E252D|MPP4_ENST00000315506.7_Intron|MPP4_ENST00000396886.3_Missense_Mutation_p.E208D|MPP4_ENST00000428900.2_Missense_Mutation_p.E252D	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	252	SH3.					cytoplasm	protein binding			kidney(1)|lung(11)	12						GGGGCCAGTACTCAGTCATGG	0.567000											OREG0015145	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	44					5.26018e-13	6.34623e-13	0.234183	1	0
GRK4	2868	broad.mit.edu	37	4	3031023	3031023	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:3031023T>C	ENST00000398052.4	+	12	1499	c.1156T>C	c.(1156-1158)Ttc>Ctc	p.F386L	GRK4_ENST00000509545.1_3'UTR|GRK4_ENST00000398051.4_Missense_Mutation_p.F354L|GRK4_ENST00000504933.1_Missense_Mutation_p.F386L|GRK4_ENST00000345167.6_Missense_Mutation_p.F354L	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	386	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		ACATTCTCCATTCAAAAAATA	0.398000													3	51					0	0	0.115264	0	0
OR2L8	391190	broad.mit.edu	37	1	248112717	248112717	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248112717G>C	ENST00000357191.3	+	1	558	c.558G>C	c.(556-558)ctG>ctC	p.L186L	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TGGTGACTCTGGCCTGCATGG	0.473000													48	233					0	0	0.323286	0	0
OR5T2	219464	broad.mit.edu	37	11	56000231	56000231	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56000231C>A	ENST00000313264.4	-	1	506	c.431G>T	c.(430-432)tGt>tTt	p.C144F		NM_001004746.1	NP_001004746.1	Q8NGG2	OR5T2_HUMAN	olfactory receptor, family 5, subfamily T, member 2	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(1)|stomach(3)	41	Esophageal squamous(21;0.00448)					TCCAAAACTACAAGCAAGAAA	0.408000													62	177					7.37877e-41	1.19394e-40	0.323286	1	0
PDE1C	5137	broad.mit.edu	37	7	31864539	31864539	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:31864539C>A	ENST00000396184.3	-	14	1552	c.1348G>T	c.(1348-1350)Gtg>Ttg	p.V450L	PDE1C_ENST00000396193.1_Missense_Mutation_p.V510L|PDE1C_ENST00000396191.1_Missense_Mutation_p.V450L|PDE1C_ENST00000396182.2_Missense_Mutation_p.V450L|PDE1C_ENST00000321453.7_Missense_Mutation_p.V450L	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	450	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			AATGGACTCACAATCTTCTCG	0.498000													87	403					1.15966e-41	1.8833e-41	0.323286	1	0
DNAH11	8701	broad.mit.edu	37	7	21599337	21599337	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:21599337T>G	ENST00000328843.6	+	4	840	c.809T>G	c.(808-810)cTt>cGt	p.L270R	DNAH11_ENST00000409508.3_Missense_Mutation_p.L270R			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	270	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTGAATGGTCTTCACTTGTCT	0.353000									Kartagener syndrome				9	31					0	0	0.307466	0	0
REG4	83998	broad.mit.edu	37	1	120345520	120345520	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:120345520A>G	ENST00000369401.4	-	3	601	c.336T>C	c.(334-336)tcT>tcC	p.S112S	REG4_ENST00000530654.1_Intron|REG4_ENST00000256585.5_Intron|REG4_ENST00000354219.1_Intron	NM_001159353.1	NP_001152825.1	Q9BYZ8	REG4_HUMAN	regenerating islet-derived family, member 4	0	C-type lectin.					extracellular region	sugar binding			central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(2)|prostate(1)|skin(2)	15	all_cancers(5;4.81e-10)|all_epithelial(5;7.98e-11)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;8.1e-07)|Lung NSC(69;5.89e-06)|all_epithelial(167;0.000959)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0588)		caatgcttacagaattgaatg	0.488000													17	21					0	0	0.189662	0	0
SECISBP2L	9728	broad.mit.edu	37	15	49320347	49320347	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:49320347A>C	ENST00000559471.1	-	6	1176	c.913T>G	c.(913-915)Tgt>Ggt	p.C305G	SECISBP2L_ENST00000261847.3_Missense_Mutation_p.C305G	NM_001193489.1	NP_001180418.1	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	305										breast(1)|endometrium(5)|kidney(8)|large_intestine(12)|lung(11)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	46						GTACCTGCACACATAGATGAT	0.318000													9	10					0	0	0.307466	0	0
DDX23	9416	broad.mit.edu	37	12	49231390	49231390	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:49231390C>A	ENST00000308025.3	-	7	749	c.670G>T	c.(670-672)Gag>Tag	p.E224*	DDX23_ENST00000553182.1_Intron	NM_004818.2	NP_004809.2	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	224	Glu-rich.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			NS(1)|cervix(1)|kidney(4)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(3)	36						CCATTGGTCTCCCGTTCCATC	0.532000													23	61					7.01153e-11	8.13285e-11	0.125774	1	0
DHTKD1	55526	broad.mit.edu	37	10	12131232	12131232	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:12131232G>A	ENST00000263035.4	+	5	1027	c.965G>A	c.(964-966)gGg>gAg	p.G322E	DHTKD1_ENST00000465617.1_Intron	NM_018706.5	NP_061176.3	Q96HY7	DHTK1_HUMAN	dehydrogenase E1 and transketolase domain containing 1	322					glycolysis	mitochondrion	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(1)	44		Renal(717;0.228)	BRCA - Breast invasive adenocarcinoma(52;0.188)			GCCCAGCCGGGGGACAGGGTC	0.592000													37	89					0	0	0.279185	0	0
TENM3	55714	broad.mit.edu	37	4	183635306	183635306	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:183635306T>C	ENST00000511685.1	+	13	2411	c.2288T>C	c.(2287-2289)gTg>gCg	p.V763A	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.V763A					teneurin transmembrane protein 3																		TGGCATTGTGTGTGCCAGCCT	0.493000													12	59					0	0	0.105934	0	0
PAPOLA	10914	broad.mit.edu	37	14	96998700	96998700	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:96998700G>C	ENST00000216277.8	+	8	860	c.640G>C	c.(640-642)Gta>Cta	p.V214L	PAPOLA_ENST00000392990.2_Missense_Mutation_p.V214L|PAPOLA_ENST00000557320.1_Missense_Mutation_p.V214L	NM_032632.4	NP_116021.2	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	214				CRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYS -> MR KPTSFCVLQFLSDISCFYTSFVLKLFIAILLTQ (in Ref. 2; CAD61935).	mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		TTTACATCTAGTACCAAACAT	0.338000													18	69					0	0	0.160694	0	0
CNGA1	1259	broad.mit.edu	37	4	47942862	47942862	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:47942862A>T	ENST00000402813.3	-	9	931	c.789T>A	c.(787-789)tcT>tcA	p.S263S	CNGA1_ENST00000358519.4_Silent_p.S194S|CNGA1_ENST00000544810.1_Silent_p.S194S|CNGA1_ENST00000420489.2_Silent_p.S194S|CNGA1_ENST00000514170.1_Silent_p.S194S			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	194					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						CTAGGTAATCAGATTGAAGTT	0.289000													21	40					0	0	0.234183	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208439	140208439	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140208439G>T	ENST00000529310.1	+	1	877	c.763G>T	c.(763-765)Gca>Tca	p.A255S	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Missense_Mutation_p.A255S|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCGAAAATGCAGACAACGG	0.438000													25	50					5.61819e-17	7.20179e-17	0.324025	1	0
F11	2160	broad.mit.edu	37	4	187196955	187196955	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:187196955T>C	ENST00000264692.4	+	6	677	c.344T>C	c.(343-345)cTg>cCg	p.L115P	F11_ENST00000403665.2_Missense_Mutation_p.L167P			P03951	FA11_HUMAN	coagulation factor XI	167	Apple 2.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	ATTTGTCTACTGAAGCACACC	0.383000													8	50					0	0	0.058154	0	0
FAM179B	23116	broad.mit.edu	37	14	45475266	45475266	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:45475266G>A	ENST00000361462.2	+	5	2883	c.2700G>A	c.(2698-2700)tcG>tcA	p.S900S	FAM179B_ENST00000361577.3_Silent_p.S900S|KLHL28_ENST00000553817.1_Intron|FAM179B_ENST00000382233.2_Silent_p.S900S			Q9Y4F4	F179B_HUMAN	family with sequence similarity 179, member B	900							binding			endometrium(4)|kidney(5)|large_intestine(12)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	45						TGGTGAGATCGCCATCTTCCC	0.413000													112	263					0	0	0.323286	0	0
FCRL1	115350	broad.mit.edu	37	1	157771895	157771895	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157771895C>G	ENST00000358292.3	-	5	747	c.696G>C	c.(694-696)ctG>ctC	p.L232L	FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Silent_p.L232L|FCRL1_ENST00000368176.3_Silent_p.L232L	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	232	Ig-like C2-type 3.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GAGAGCCTCTCAGGGCCTCAC	0.617000													49	104					0	0	0.323286	0	0
CFHR1	3078	broad.mit.edu	37	1	196797377	196797377	+	Splice_Site	SNP	G	G	T	rs112994000		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:196797377G>T	ENST00000320493.5	+	4	695		c.e4+1		CFHR1_ENST00000367424.3_Intron|CFHR2_ENST00000367421.3_Intron	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1						complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						CAATGCAAAGGTAGAGTATTA	0.323000													68	29					1.64915e-30	2.47693e-30	0.323286	1	0
MED13	9969	broad.mit.edu	37	17	60059767	60059767	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:60059767T>C	ENST00000397786.2	-	16	3673	c.3597A>G	c.(3595-3597)ttA>ttG	p.L1199L		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1199					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						AGGGTGAAAATAAATTAGTGC	0.393000													33	94					0	0	0.193644	0	0
C15orf52	388115	broad.mit.edu	37	15	40630806	40630806	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:40630806C>A	ENST00000559313.1	-	5	590	c.575G>T	c.(574-576)gGg>gTg	p.G192V		NM_207380.2	NP_997263.2	Q6ZUT6	CO052_HUMAN	chromosome 15 open reading frame 52	192										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	19		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		TCCAGGTGACCCCTCTATGCC	0.592000											OREG0023060	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	44					1.16021e-09	1.31521e-09	0.125774	1	0
IGKV6D-21	28870	broad.mit.edu	37	2	90060771	90060771	+	RNA	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:90060771A>G	ENST00000436451.2	+	0	185																											GAAAGTCACCATCACCTGCCG	0.483000													26	35					0	0	0.183431	0	0
DENND5A	23258	broad.mit.edu	37	11	9192301	9192301	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:9192301C>T	ENST00000328194.3	-	9	2250	c.1930G>A	c.(1930-1932)Gca>Aca	p.A644T	DENND5A_ENST00000527700.1_5'UTR|DENND5A_ENST00000530044.1_Missense_Mutation_p.A644T	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	644										breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TCAATTTTTGCCAGACGCAGC	0.413000													4	181					0	0	0.150653	0	0
OR6C75	390323	broad.mit.edu	37	12	55759174	55759174	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55759174G>T	ENST00000343399.3	+	1	280	c.280G>T	c.(280-282)Ggg>Tgg	p.G94W		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G94W(1)		endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						TTCTTATAATGGGTGTGTGGC	0.453000													65	155					3.94896e-32	6.0246e-32	0.323286	1	0
ZFP90	146198	broad.mit.edu	37	16	68597847	68597847	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:68597847G>T	ENST00000570495.1	+	5	1449	c.1157G>T	c.(1156-1158)aGg>aTg	p.R386M	ZFP90_ENST00000398253.2_Missense_Mutation_p.R386M|ZFP90_ENST00000563169.2_Missense_Mutation_p.R386M|RP11-615I2.7_ENST00000571720.1_RNA			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	386					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		CAACATGAGAGGACTCATACT	0.463000													50	78					5.22555e-25	7.41684e-25	0.323286	1	0
CCDC87	55231	broad.mit.edu	37	11	66359146	66359146	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66359146C>A	ENST00000333861.3	-	1	1408	c.1341G>T	c.(1339-1341)cgG>cgT	p.R447R		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	447										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						TATCAGAGACCCGTACGGCAG	0.527000													12	36					5.50884e-06	5.89729e-06	0.093190	1	0
SYDE2	84144	broad.mit.edu	37	1	85655785	85655785	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:85655785C>T	ENST00000341460.5	-	2	1445	c.1396G>A	c.(1396-1398)Ggt>Agt	p.G466S		NM_032184.1	NP_115560.1	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	466					activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	20				all cancers(265;0.0126)|Epithelial(280;0.0336)		ACCATTATACCTTCTTGTGTC	0.388000													8	342					0	0	0.069234	0	0
RALYL	138046	broad.mit.edu	37	8	85441629	85441629	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:85441629A>T	ENST00000521268.1	+	2	1178	c.73A>T	c.(73-75)Atc>Ttc	p.I25F	RALYL_ENST00000522455.1_Missense_Mutation_p.I25F|RALYL_ENST00000518566.1_Missense_Mutation_p.I25F|RALYL_ENST00000521695.1_Missense_Mutation_p.I25F|RALYL_ENST00000517638.1_Missense_Mutation_p.I38F	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	25	RRM.						identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						CCGTGTTTTCATCGGCAATCT	0.403000													12	22					0	0	0.080935	0	0
OR6C68	403284	broad.mit.edu	37	12	55886799	55886799	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55886799T>G	ENST00000379662.1	+	1	653	c.653T>G	c.(652-654)gTt>gGt	p.V218G	RP11-110A12.2_ENST00000554049.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|OR6C68_ENST00000548615.1_Missense_Mutation_p.V213G|RP11-110A12.2_ENST00000556750.1_RNA			A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C, member 68	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15						GTATGTGTAGTTCTGTCCTAC	0.343000													11	66					0	0	0.080935	0	0
DLC1	10395	broad.mit.edu	37	8	13357088	13357088	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:13357088C>T	ENST00000276297.4	-	2	902	c.493G>A	c.(493-495)Gga>Aga	p.G165R	DLC1_ENST00000316609.5_Missense_Mutation_p.G165R|DLC1_ENST00000511869.1_Missense_Mutation_p.G165R	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	165					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CCAGCTATTCCCCAGGAGTTA	0.423000													51	18					0	0	0.323286	0	0
LOC440040	440040	broad.mit.edu	37	11	49598103	49598103	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:49598103G>T	ENST00000527477.1	+	0	707																											GCTGGCATTCGGCTGTGGCCC	0.527000													25	45					7.07758e-08	7.80323e-08	0.309145	1	0
MMS19	64210	broad.mit.edu	37	10	99225839	99225839	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:99225839T>A	ENST00000438925.2	-	17	1918	c.1583A>T	c.(1582-1584)aAg>aTg	p.K528M	MMS19_ENST00000327238.10_Missense_Mutation_p.K430M|MMS19_ENST00000370782.2_Missense_Mutation_p.K528M|MMS19_ENST00000355839.6_Missense_Mutation_p.K485M|MMS19_ENST00000327277.7_Missense_Mutation_p.K164M	NM_022362.4	NP_071757.4	Q96T76	MMS19_HUMAN	MMS19 nucleotide excision repair homolog (S. cerevisiae)	528					chromosome segregation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|response to hormone stimulus|transcription, DNA-dependent|two-component signal transduction system (phosphorelay)	cytoplasm|holo TFIIH complex|MMXD complex	estrogen receptor binding|protein binding, bridging|receptor signaling complex scaffold activity|transcription coactivator activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|stomach(1)	16		Colorectal(252;0.0846)		Epithelial(162;3.33e-10)|all cancers(201;2.74e-08)		CTCAGCGAGCTTGGGTACGAG	0.582000								Direct reversal of damage					13	18					0	0	0.132662	0	0
ASTN1	460	broad.mit.edu	37	1	177133590	177133590	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:177133590G>T	ENST00000367654.2	-	1	236	c.223C>A	c.(223-225)Ccg>Acg	p.P75T	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.P75T|ASTN1_ENST00000361833.2_Missense_Mutation_p.P75T|ASTN1_ENST00000367657.3_Missense_Mutation_p.P75T			O14525	ASTN1_HUMAN	astrotactin 1	75					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						ATTTCTCCCGGGAAGTCGTTG	0.667000													36	58					7.04047e-22	9.66505e-22	0.225048	1	0
FLJ42102	399923	broad.mit.edu	37	11	71117665	71117665	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:71117665G>T	ENST00000331301.4	-	0	1288					NR_038862.1																						CGACATCTGAGATCTTCCACG	0.517000													6	14					0.000442599	0.000461525	0.058154	1	0
ATP2B3	492	broad.mit.edu	37	X	152825187	152825187	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:152825187G>T	ENST00000370186.1	+	16	2910	c.2583_splice	c.e16-1	p.D862_splice	ATP2B3_ENST00000263519.4_Splice_Site_p.D876_splice|ATP2B3_ENST00000393842.1_Splice_Site_p.D862_splice|ATP2B3_ENST00000460549.1_3'UTR|ATP2B3_ENST00000349466.2_Splice_Site_p.D876_splice|ATP2B3_ENST00000359149.3_Splice_Site_p.D876_splice|ATP2B3_ENST00000370181.2_Splice_Site_p.D862_splice			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	876					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTCTCCATAGGACTCTCCTCT	0.607000													27	2					6.38683e-12	7.57565e-12	0.134883	1	0
LAMA2	3908	broad.mit.edu	37	6	129802528	129802528	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:129802528T>C	ENST00000421865.2	+	55	7742	c.7693T>C	c.(7693-7695)Ttg>Ctg	p.L2565L	RP1-69D17.3_ENST00000442449.1_RNA	NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2565	Laminin G-like 3.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CATCATTCTTTTGGGAAGTGG	0.483000													92	158					0	0	0.323286	0	0
NMUR2	56923	broad.mit.edu	37	5	151784488	151784488	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:151784488T>A	ENST00000255262.3	-	1	352	c.187A>T	c.(187-189)Aat>Tat	p.N63Y	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	63					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			ACCAGGACATTGCCAATGACC	0.582000													32	55					0	0	0.183431	0	0
ZFYVE1	53349	broad.mit.edu	37	14	73448514	73448514	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:73448514G>A	ENST00000556143.1	-	5	2013	c.1293C>T	c.(1291-1293)tcC>tcT	p.S431S	ZFYVE1_ENST00000394207.2_Silent_p.S16S|ZFYVE1_ENST00000555072.1_Silent_p.S16S|ZFYVE1_ENST00000553891.1_Silent_p.S431S|ZFYVE1_ENST00000318876.5_Silent_p.S431S	NM_021260.2	NP_067083.1	Q9HBF4	ZFYV1_HUMAN	zinc finger, FYVE domain containing 1	431						endoplasmic reticulum|Golgi stack|perinuclear region of cytoplasm	1-phosphatidylinositol binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(17)|ovary(1)|prostate(2)|skin(1)	35		all_lung(585;1.33e-09)		OV - Ovarian serous cystadenocarcinoma(108;1.6e-46)|BRCA - Breast invasive adenocarcinoma(234;0.00349)		TGAGGCACAAGGAGGAGCAGG	0.552000													74	117					0	0	0.323286	0	0
SNTG1	54212	broad.mit.edu	37	8	51415438	51415438	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:51415438C>A	ENST00000522124.1	+	9	1125	c.464C>A	c.(463-465)gCa>gAa	p.A155E	SNTG1_ENST00000517473.1_Missense_Mutation_p.A155E|SNTG1_ENST00000276467.5_Missense_Mutation_p.A155E|SNTG1_ENST00000518864.1_Missense_Mutation_p.A155E	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	155					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				GAAGATTGTGCATGTAAGCAT	0.323000													16	21					2.62699e-14	3.24393e-14	0.132662	1	0
ROPN1	54763	broad.mit.edu	37	3	123688964	123688964	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:123688964G>C	ENST00000184183.4	-	6	837	c.497C>G	c.(496-498)aCg>aGg	p.T166R	ROPN1_ENST00000405845.3_Missense_Mutation_p.T166R	NM_017578.2	NP_060048.2	Q9HAT0	ROP1A_HUMAN	rhophilin associated tail protein 1	166					signal transduction		cAMP-dependent protein kinase regulator activity			lung(2)|ovary(1)|skin(1)	4				GBM - Glioblastoma multiforme(114;0.148)		GGCAATATACGTGTAGAGAAA	0.453000													104	72					0	0	0.323286	0	0
OTOF	9381	broad.mit.edu	37	2	26693547	26693547	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:26693547C>T	ENST00000272371.2	-	32	4063	c.3937G>A	c.(3937-3939)Gcg>Acg	p.A1313T	OTOF_ENST00000402415.3_Missense_Mutation_p.A623T|OTOF_ENST00000339598.3_Missense_Mutation_p.A546T|OTOF_ENST00000403946.3_Missense_Mutation_p.A1313T|OTOF_ENST00000338581.6_Missense_Mutation_p.A546T	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1313					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCTCCTCCGCAGTGCCcttc	0.577000													4	66					0	0	0.150653	0	0
SERPINB13	5275	broad.mit.edu	37	18	61264337	61264337	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:61264337G>A	ENST00000344731.5	+	8	1018	c.916G>A	c.(916-918)Ggc>Agc	p.G306S	SERPINB13_ENST00000269489.5_Missense_Mutation_p.G254S	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	306					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						CATGGGGATGGGCGATGCCTT	0.562000													62	154					0	0	0.323286	0	0
PARN	5073	broad.mit.edu	37	16	14576590	14576590	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:14576590C>T	ENST00000437198.2	-	22	1716	c.1575G>A	c.(1573-1575)aaG>aaA	p.K525K	PARN_ENST00000420015.2_Silent_p.K479K|PARN_ENST00000539279.1_Silent_p.K350K|PARN_ENST00000341484.7_Silent_p.K464K	NM_001134477.2|NM_002582.3	NP_001127949.1|NP_002573.1	O95453	PARN_HUMAN	poly(A)-specific ribonuclease	525					female gamete generation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|RNA modification	cytosol|nucleolus	metal ion binding|mRNA 3'-UTR binding|nucleotide binding|poly(A)-specific ribonuclease activity|protein binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|urinary_tract(1)	21						CTTCAGTCCACTTTCTTTTGA	0.443000													51	31					0	0	0.323286	0	0
BAZ2B	29994	broad.mit.edu	37	2	160239263	160239263	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:160239263C>A	ENST00000392783.2	-	25	4307	c.3812G>T	c.(3811-3813)gGc>gTc	p.G1271V	BAZ2B_ENST00000343439.5_Missense_Mutation_p.G1171V|BAZ2B_ENST00000355831.2_Missense_Mutation_p.G1237V|BAZ2B_ENST00000392782.1_Missense_Mutation_p.G1235V	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						CAGATCAATGCCACCTGAAGT	0.433000													5	83					0.000602214	0.000625229	0.184627	1	0
PLXNA4	91584	broad.mit.edu	37	7	132193253	132193253	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:132193253G>T	ENST00000359827.3	-	2	1162	c.200C>A	c.(199-201)gCc>gAc	p.A67D	PLXNA4_ENST00000423507.2_Missense_Mutation_p.A67D|PLXNA4_ENST00000321063.4_Missense_Mutation_p.A67D|PLXNA4_ENST00000378539.5_Missense_Mutation_p.A67D			Q9HCM2	PLXA4_HUMAN	plexin A4	67	Sema.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						CCGATTGACGGCCCCCAAGTA	0.572000													55	75					2.30037e-20	3.09212e-20	0.323286	1	0
SEPT11	55752	broad.mit.edu	37	4	77952117	77952117	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:77952117A>C	ENST00000264893.6	+	9	1469	c.1268A>C	c.(1267-1269)aAg>aCg	p.K423T	SEPT11_ENST00000502584.1_Missense_Mutation_p.K423T|SEPT11_ENST00000512575.1_3'UTR|SEPT11_ENST00000510515.1_Missense_Mutation_p.K433T|SEPT11_ENST00000541121.1_Missense_Mutation_p.K433T|SEPT11_ENST00000505788.1_Missense_Mutation_p.K423T	NM_018243.2	NP_060713.1	Q9NVA2	SEP11_HUMAN	septin 11	423					cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(1)|skin(1)|stomach(1)	11						GACAAGGATAAGAAAAAGTAA	0.483000													17	71					0	0	0.175082	0	0
CADM3	57863	broad.mit.edu	37	1	159163278	159163278	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:159163278C>A	ENST00000368125.4	+	4	605	c.448C>A	c.(448-450)Cta>Ata	p.L150I	CADM3_ENST00000368124.4_Missense_Mutation_p.L184I	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	150	Ig-like C2-type 1.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					CACAGCCACCCTAAACTGTCA	0.527000													38	129					6.17242e-35	9.63507e-35	0.323286	1	0
FKBP9L	360132	broad.mit.edu	37	7	55755555	55755555	+	RNA	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:55755555T>C	ENST00000455909.1	-	0	451					NR_027340.1|NR_027342.1				FK506 binding protein 9-like											endometrium(1)|kidney(1)|lung(3)	5						GAGACCCATGTCCATCCCCAA	0.498000													63	160					0	0	0.323286	0	0
ARL14EP	120534	broad.mit.edu	37	11	30358292	30358292	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:30358292C>G	ENST00000282032.3	+	4	948	c.733C>G	c.(733-735)Caa>Gaa	p.Q245E		NM_152316.1	NP_689529.1			ADP-ribosylation factor-like 14 effector protein																		GCTGTATGAGCAAATTGAAAT	0.418000													4	185					0	0	0.150653	0	0
C17orf66	256957	broad.mit.edu	37	17	34185940	34185940	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:34185940C>G	ENST00000311880.2	-	9	1039	c.891G>C	c.(889-891)gaG>gaC	p.E297D	C17orf66_ENST00000592980.1_Missense_Mutation_p.E257D	NM_152781.2	NP_689994.2	A2RTY3	CQ066_HUMAN	chromosome 17 open reading frame 66	297							binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(6)|lung(11)|skin(2)|stomach(4)	38		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0184)		GCAACAAGAACTCTTGGACCA	0.562000													184	511					0	0	0.323286	0	0
DAB2	1601	broad.mit.edu	37	5	39383268	39383268	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:39383268G>T	ENST00000545653.1	-	9	1260	c.730C>A	c.(730-732)Ctt>Att	p.L244I	DAB2_ENST00000339788.6_Intron|DAB2_ENST00000509337.1_Missense_Mutation_p.L244I|DAB2_ENST00000320816.6_Missense_Mutation_p.L265I	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	265					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GGTCGAGGAAGAGAACAGGAG	0.438000													238	244					5.07926e-101	9.27504e-101	0.323286	1	0
GRM4	2914	broad.mit.edu	37	6	34100864	34100864	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:34100864C>A	ENST00000374181.3	-	1	579	c.410G>T	c.(409-411)gGc>gTc	p.G137V	GRM4_ENST00000538487.1_Missense_Mutation_p.G137V|GRM4_ENST00000374177.3_Intron	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	137					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	GCCGCCACTGCCACAGCGGAC	0.617000													8	11					7.07596e-05	7.4589e-05	0.175082	1	0
PRICKLE3	4007	broad.mit.edu	37	X	49034420	49034420	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:49034420G>A	ENST00000376317.3	-	7	971	c.877C>T	c.(877-879)Cgt>Tgt	p.R293C	PRICKLE3_ENST00000540849.1_Missense_Mutation_p.R225C|PRICKLE3_ENST00000536904.1_Missense_Mutation_p.R212C|PRICKLE3_ENST00000538114.1_Intron	NM_006150.3	NP_006141.2	O43900	PRIC3_HUMAN	prickle homolog 3 (Drosophila)	293	LIM zinc-binding 2.						protein binding|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|skin(2)	22						CGGCTCTGACGCATGACATAG	0.632000													70	77					0	0	0.323286	0	0
UHRF2	115426	broad.mit.edu	37	9	6504600	6504600	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:6504600T>A	ENST00000276893.5	+	15	2339	c.2171T>A	c.(2170-2172)cTg>cAg	p.L724Q	UHRF2_ENST00000485617.2_3'UTR	NM_152896.2	NP_690856.1	Q96PU4	UHRF2_HUMAN	ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase	724					cell cycle|cell differentiation|cell proliferation|protein autoubiquitination|regulation of cell cycle|ubiquitin-dependent protein catabolic process	nucleus	DNA binding|histone binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(2)|endometrium(2)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)	17		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0392)|Lung(218;0.129)		TAGAATTTTCTGAAAAAATTG	0.348000													25	33					0	0	0.324025	0	0
CLIP2	7461	broad.mit.edu	37	7	73811555	73811555	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:73811555A>T	ENST00000223398.6	+	14	3199	c.2872A>T	c.(2872-2874)Acc>Tcc	p.T958S	CLIP2_ENST00000361545.5_Missense_Mutation_p.T923S|CLIP2_ENST00000395060.1_Missense_Mutation_p.T958S	NM_003388.4	NP_003379.3	Q9UDT6	CLIP2_HUMAN	CAP-GLY domain containing linker protein 2	958						microtubule associated complex				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|pancreas(1)|prostate(2)|skin(3)	30						TGAAAAGCTGACCGGGCTGGT	0.637000													7	24					0	0	0.248553	0	0
ANKS1B	56899	broad.mit.edu	37	12	100200223	100200223	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:100200223C>A	ENST00000547776.2	-	4	627	c.628G>T	c.(628-630)Gtg>Ttg	p.V210L	ANKS1B_ENST00000329257.7_Missense_Mutation_p.V210L|ANKS1B_ENST00000547010.1_Intron	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	210						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		AGCACCTGCACGACTGCTTTG	0.488000													52	49					4.09106e-26	5.87664e-26	0.323286	1	0
FGR	2268	broad.mit.edu	37	1	27950358	27950358	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:27950358C>A	ENST00000374005.3	-	3	358	c.70G>T	c.(70-72)Gac>Tac	p.D24Y	FGR_ENST00000468038.1_5'UTR|FGR_ENST00000545953.1_Missense_Mutation_p.D24Y|FGR_ENST00000399173.1_Missense_Mutation_p.D24Y|FGR_ENST00000374004.1_Missense_Mutation_p.D24Y	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	24					platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CTTCTGAAGTCCCCTTCCAGG	0.592000													32	25					5.91797e-21	8.02801e-21	0.163468	1	0
CNGB1	1258	broad.mit.edu	37	16	57953129	57953129	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:57953129G>T	ENST00000564448.1	-	20	1873	c.1813C>A	c.(1813-1815)Cca>Aca	p.P605T	CNGB1_ENST00000251102.8_Missense_Mutation_p.P611T			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	611					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						TTTGTGTCTGGAGCTGGCTCT	0.577000													30	69					4.16155e-14	5.11441e-14	0.268233	1	0
SYNJ2	8871	broad.mit.edu	37	6	158497793	158497793	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:158497793A>G	ENST00000355585.4	+	17	2503	c.2428A>G	c.(2428-2430)Aaa>Gaa	p.K810E	SYNJ2_ENST00000367122.2_Missense_Mutation_p.K810E|SYNJ2_ENST00000367121.3_Missense_Mutation_p.K810E	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	810							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		GTGGAGGAAGAAACATCCCTT	0.567000													49	31					0	0	0.323286	0	0
SZT2	23334	broad.mit.edu	37	1	43896739	43896739	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:43896739G>T	ENST00000562955.1	+	32	4723	c.4723G>T	c.(4723-4725)Gcc>Tcc	p.A1575S	SZT2_ENST00000372442.1_Missense_Mutation_p.A733S	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1632						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						GCTCCCCACGGCCTCGGACCC	0.607000													37	69					1.00001e-27	1.45879e-27	0.279185	1	0
CDHR2	54825	broad.mit.edu	37	5	176002107	176002107	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:176002107G>A	ENST00000510636.1	+	8	792	c.518G>A	c.(517-519)aGc>aAc	p.S173N	CDHR2_ENST00000261944.5_Missense_Mutation_p.S173N|CDHR2_ENST00000506348.1_Missense_Mutation_p.S173N	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	173	Cadherin 2.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						ACTGGGGACAGCGAGCATCTC	0.602000													17	22					0	0	0.160694	0	0
CDX1	1044	broad.mit.edu	37	5	149563052	149563052	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:149563052C>T	ENST00000231656.8	+	3	689	c.607C>T	c.(607-609)Caa>Taa	p.Q203*		NM_001804.2	NP_001795.2	P47902	CDX1_HUMAN	caudal type homeobox 1	203						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|lung(1)|ovary(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GATCTGGTTCCAAAACCGGCG	0.587000													5	10					0	0	0.248553	0	0
GLI3	2737	broad.mit.edu	37	7	42262847	42262847	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:42262847C>A	ENST00000395925.3	-	2	90	c.6G>T	c.(4-6)gaG>gaT	p.E2D	GLI3_ENST00000437480.1_Missense_Mutation_p.E2D	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	2					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GGGACTGGGCCTCCATGATGT	0.433000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				69	121					1.24833e-42	2.04015e-42	0.323286	1	0
WDR88	126248	broad.mit.edu	37	19	33628604	33628604	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:33628604G>T	ENST00000361680.2	+	2	376	c.298G>T	c.(298-300)Ggg>Tgg	p.G100W	WDR88_ENST00000592765.1_Missense_Mutation_p.G100W|WDR88_ENST00000355868.3_Missense_Mutation_p.G100W			Q6ZMY6	WDR88_HUMAN	WD repeat domain 88	100										breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	25	Esophageal squamous(110;0.137)					AATTCTGAGTGGGCACGAGCA	0.458000													13	79					3.27435e-08	3.62426e-08	0.119110	1	0
LCE1B	353132	broad.mit.edu	37	1	152784985	152784985	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152784985T>A	ENST00000360090.3	+	1	539	c.63T>A	c.(61-63)ccT>ccA	p.P21P		NM_178349.1	NP_848126.1	Q5T7P3	LCE1B_HUMAN	late cornified envelope 1B	21	Pro-rich.				keratinization					breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(5)|skin(2)	18	Lung NSC(65;9.06e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ccaagtgccctcccaagtgcc	0.617000													108	303					0	0	0.323286	0	0
BPIFB4	149954	broad.mit.edu	37	20	31685514	31685514	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:31685514T>A	ENST00000375483.3	+	11	1490	c.1490T>A	c.(1489-1491)cTg>cAg	p.L497Q		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	497						cytoplasm|extracellular region	lipid binding										GACAAAGCGCTGGTGAAGGTG	0.572000													115	106					0	0	0.323286	0	0
COBL	23242	broad.mit.edu	37	7	51095861	51095861	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:51095861G>C	ENST00000395542.2	-	12	3362	c.3178C>G	c.(3178-3180)Ctg>Gtg	p.L1060V	COBL_ENST00000265136.7_Missense_Mutation_p.L978V			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	978								p.L978M(1)		NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GACTGAACCAGTGAGAAACAG	0.557000													20	77					0	0	0.279207	0	0
PDE6B	5158	broad.mit.edu	37	4	619536	619536	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:619536C>A	ENST00000255622.6	+	1	164	c.121C>A	c.(121-123)Ccg>Acg	p.P41T	PDE6B_ENST00000496514.1_Missense_Mutation_p.P41T	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	41					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						GGACGGGTGCCCGCCGGACTG	0.647000													4	9					0.000602214	0.000625229	0.184627	1	0
TUBA1C	84790	broad.mit.edu	37	12	49666756	49666756	+	Nonsense_Mutation	SNP	G	G	T	rs146417733		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:49666756G>T	ENST00000301072.6	+	4	1371	c.1096G>T	c.(1096-1098)Gga>Tga	p.G366*	TUBA1C_ENST00000541364.1_Nonsense_Mutation_p.G436*|RP11-161H23.5_ENST00000550468.2_RNA	NM_032704.3	NP_116093.1	Q9BQE3	TBA1C_HUMAN	tubulin, alpha 1c	366					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)	13						GGTGCCTGGCGGAGACCTGGC	0.557000													41	73					2.2871e-25	3.26713e-25	0.257332	1	0
LILRP2	79166	broad.mit.edu	37	19	55221374	55221374	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:55221374G>T	ENST00000413439.1	+	0	1154																											GACCCTGCAGGGCCCTGTCGT	0.607000													49	1					2.76378e-25	3.93537e-25	0.323286	1	0
HCRTR2	3062	broad.mit.edu	37	6	55113465	55113465	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:55113465C>T	ENST00000370862.3	+	2	588	c.252C>T	c.(250-252)caC>caT	p.H84H		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	84					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			AGAACCACCACATGAGGACGG	0.443000													181	130					0	0	0.323286	0	0
TNN	63923	broad.mit.edu	37	1	175048830	175048830	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:175048830G>T	ENST00000239462.4	+	3	884	c.771G>T	c.(769-771)ctG>ctT	p.L257L		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	257	EGF-like 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TCACAGGCCTGGACTGTGCCC	0.617000													9	17					0.00621372	0.00636372	0.058154	1	0
CACNA1C	775	broad.mit.edu	37	12	2659199	2659199	+	Splice_Site	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:2659199C>G	ENST00000399655.1	+	10	1746	c.1481_splice	c.e10+1	p.A494_splice	CACNA1C_ENST00000399637.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399597.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000344100.3_Splice_Site_p.A494_splice|CACNA1C_ENST00000327702.7_Splice_Site_p.A494_splice|CACNA1C_ENST00000399601.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399621.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399644.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399641.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399629.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399617.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399638.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000402845.3_Splice_Site_p.A494_splice|CACNA1C_ENST00000406454.3_Splice_Site_p.A494_splice|CACNA1C_ENST00000399591.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399649.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399634.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000480911.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000347598.4_Splice_Site_p.A494_splice|CACNA1C_ENST00000491104.1_3'UTR|CACNA1C_ENST00000399606.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000335762.5_Splice_Site_p.A519_splice|CACNA1C_ENST00000399595.1_Splice_Site_p.A494_splice|CACNA1C_ENST00000399603.1_Splice_Site_p.A494_splice	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	494					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GCCAGGCTGGCGTGAGTAGGC	0.592000													6	13					0	0	0.217242	0	0
SPTA1	6708	broad.mit.edu	37	1	158612234	158612234	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158612234A>G	ENST00000368148.3	-	33	4884	c.4704T>C	c.(4702-4704)tgT>tgC	p.C1568C	SPTA1_ENST00000368147.3_Silent_p.C1568C	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1568			C -> R (in dbSNP:rs863931).		actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CACAAGCGCTACACTCAATCA	0.463000													63	150					0	0	0.323286	0	0
CNIH3	149111	broad.mit.edu	37	1	224922382	224922382	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:224922382C>A	ENST00000272133.3	+	5	1311	c.429C>A	c.(427-429)ctC>ctA	p.L143L		NM_152495.1	NP_689708.1	Q8TBE1	CNIH3_HUMAN	cornichon family AMPA receptor auxiliary protein 3	143					intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane				large_intestine(5)|lung(4)	9	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		CCTTCTATCTCCTCTCCTTCT	0.517000													93	257					4.66267e-56	8.05371e-56	0.323286	1	0
SORCS3	22986	broad.mit.edu	37	10	107022242	107022242	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:107022242G>T	ENST00000369701.3	+	26	3824	c.3597G>T	c.(3595-3597)cgG>cgT	p.R1199R		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1199						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TGGACACGCGGGTCATAGGTA	0.532000													19	41					1.56452e-12	1.87078e-12	0.189662	1	0
MYH4	4622	broad.mit.edu	37	17	10352218	10352218	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:10352218C>A	ENST00000255381.2	-	31	4438	c.4328G>T	c.(4327-4329)tGc>tTc	p.C1443F	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1443					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GAGAGCTATGCAGGCAGCATT	0.443000													28	41					7.26314e-15	9.03734e-15	0.125774	1	0
CPN2	1370	broad.mit.edu	37	3	194062798	194062798	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:194062798C>A	ENST00000323830.3	-	2	723	c.634G>T	c.(634-636)Gtg>Ttg	p.V212L	CPN2_ENST00000429275.1_Missense_Mutation_p.V212L	NM_001080513.2	NP_001073982.2	P22792	CPN2_HUMAN	carboxypeptidase N, polypeptide 2	212					protein stabilization	extracellular region	enzyme regulator activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(5)|prostate(1)	27	all_cancers(143;5.31e-09)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.2e-17)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.65e-05)		TTGCCAAACACACCCTGGGGG	0.617000													7	39					1.08611e-07	1.19026e-07	0.080935	1	0
INHA	3623	broad.mit.edu	37	2	220439498	220439498	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220439498A>G	ENST00000243786.2	+	2	531	c.351A>G	c.(349-351)ccA>ccG	p.P117P	INHA_ENST00000489456.1_3'UTR	NM_002191.3	NP_002182.1	P05111	INHA_HUMAN	inhibin, alpha	117					cell cycle arrest|cell surface receptor linked signaling pathway|cell-cell signaling|erythrocyte differentiation|hemoglobin biosynthetic process|induction of apoptosis|negative regulation of B cell differentiation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|regulation of cell proliferation|response to external stimulus|skeletal system development	inhibin A complex|inhibin-betaglycan-ActRII complex	cytokine activity|growth factor activity|hormone activity|signal transducer activity			large_intestine(2)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	10		Renal(207;0.0183)		Epithelial(149;4.58e-07)|all cancers(144;4.31e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00802)		TGTTCCGGCCATCCCAGCATA	0.622000													41	41					0	0	0.323286	0	0
AKAP17A	8227	broad.mit.edu	37	X	1720179	1720179	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:1720179G>T	ENST00000313871.3	+	5	1976	c.1780G>T	c.(1780-1782)Ggg>Tgg	p.G594W		NM_005088.2	NP_005079.2	Q02040	AK17A_HUMAN	A kinase (PRKA) anchor protein 17A	594	Arg-rich.				B cell activation|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|signal transduction	nuclear speck|spliceosomal complex	nucleotide binding|protein binding|RNA binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)	26						CACCGGAGACGGGCTTGCTGA	0.701000													9	2					2.80697e-09	3.15772e-09	0.080935	1	0
CHRM3	1131	broad.mit.edu	37	1	240071185	240071185	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:240071185T>G	ENST00000255380.4	+	5	1213	c.434T>G	c.(433-435)cTt>cGt	p.L145R		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	145					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity	p.L145P(1)		breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GACCTCTGGCTTGCCATTGAC	0.488000													9	141					0	0	0.093190	0	0
NBN	4683	broad.mit.edu	37	8	90993627	90993627	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:90993627A>G	ENST00000265433.3	-	3	450	c.296T>C	c.(295-297)tTt>tCt	p.F99S	NBN_ENST00000409330.1_Missense_Mutation_p.F17S	NM_002485.4	NP_002476.2	O60934	NBN_HUMAN	nibrin	99					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator|DNA duplex unwinding|double-strand break repair via homologous recombination|meiosis|mitotic cell cycle G1/S transition checkpoint|mitotic cell cycle G2/M transition DNA damage checkpoint|positive regulation of kinase activity|positive regulation of protein autophosphorylation|regulation of DNA-dependent DNA replication initiation|telomere maintenance	Mre11 complex|nuclear chromosome, telomeric region|nuclear inclusion body|nucleolus|nucleoplasm	protein N-terminus binding|transcription factor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27			BRCA - Breast invasive adenocarcinoma(11;0.0344)			AAACACTCCAAAAGTAATACC	0.323000								Homologous recombination					17	71					0	0	0.175082	0	0
ADAMTS9	56999	broad.mit.edu	37	3	64672312	64672312	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:64672312A>T	ENST00000498707.1	-	2	790	c.448T>A	c.(448-450)Tgt>Agt	p.C150S	ADAMTS9-AS2_ENST00000474768.1_RNA|ADAMTS9_ENST00000459780.1_Missense_Mutation_p.C150S|ADAMTS9-AS2_ENST00000485174.1_RNA|ADAMTS9-AS2_ENST00000460833.1_RNA|ADAMTS9-AS2_ENST00000481312.1_RNA|ADAMTS9_ENST00000295903.4_Missense_Mutation_p.C150S	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	150					glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		TTGTAGAAACAGTGCTTGAGT	0.557000													8	34					0	0	0.058154	0	0
LRP4	4038	broad.mit.edu	37	11	46924422	46924422	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:46924422A>T	ENST00000378623.1	-	2	353	c.111T>A	c.(109-111)agT>agA	p.S37R		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	37	LDL-receptor class A 1.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CTCCAAGAGCACTCACTGCAC	0.592000													11	50					0	0	0.093190	0	0
SLC6A4	6532	broad.mit.edu	37	17	28548791	28548791	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:28548791A>G	ENST00000401766.2	-	2	698	c.186T>C	c.(184-186)tcT>tcC	p.S62S	SLC6A4_ENST00000261707.3_Silent_p.S62S			P31645	SC6A4_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 4	62					response to toxin|serotonin uptake|thalamus development	cytosol|endomembrane system|endosome membrane|membrane raft	actin filament binding|Rab GTPase binding|serotonin transmembrane transporter activity|serotonin:sodium symporter activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(4)	25					Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Citalopram(DB00215)|Clomipramine(DB01242)|Cocaine(DB00907)|Desipramine(DB01151)|Dexfenfluramine(DB01191)|Dextromethorphan(DB00514)|Doxepin(DB01142)|Duloxetine(DB00476)|Escitalopram(DB01175)|Fluoxetine(DB00472)|Fluvoxamine(DB00176)|Imipramine(DB00458)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Minaprine(DB00805)|Nefazodone(DB01149)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phentermine(DB00191)|Protriptyline(DB00344)|Sertraline(DB01104)|Sibutramine(DB01105)|Tegaserod(DB01079)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)|Zimelidine(DB04832)	TCGCTGGGATAGAGTGCCGTG	0.562000													81	172					0	0	0.323286	0	0
SPHK1	8877	broad.mit.edu	37	17	74383160	74383160	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:74383160A>T	ENST00000545180.1	+	8	1457	c.648A>T	c.(646-648)ggA>ggT	p.G216G	SPHK1_ENST00000590959.1_Silent_p.G230G|SPHK1_ENST00000323374.4_Silent_p.G302G|SPHK1_ENST00000592299.1_Silent_p.G216G|SPHK1_ENST00000392496.3_Silent_p.G216G			Q9NYA1	SPHK1_HUMAN	sphingosine kinase 1	216					'de novo' posttranslational protein folding|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|calcium-mediated signaling|positive regulation of angiogenesis|positive regulation of cell growth|positive regulation of cell migration|positive regulation of fibroblast proliferation|positive regulation of mitotic cell cycle|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|positive regulation of smooth muscle contraction|regulation of tumor necrosis factor-mediated signaling pathway|sphingoid catabolic process|sphingosine metabolic process	cytosol|membrane fraction|nucleus|plasma membrane|soluble fraction	ATP binding|calmodulin binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|DNA binding|magnesium ion binding|protein phosphatase 2A binding|sphinganine kinase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)	11						TCCCTGTAGGAAGAGTGGGTT	0.647000													10	13					0	0	0.058154	0	0
ABCF3	55324	broad.mit.edu	37	3	183911183	183911183	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:183911183A>T	ENST00000429586.2	+	20	2099	c.1914A>T	c.(1912-1914)acA>acT	p.T638T	ABCF3_ENST00000292808.5_Silent_p.T632T|EIF2B5_ENST00000444495.1_Intron	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	638	ABC transporter 2.						ATP binding|ATPase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATGAACCCACAAACCACCTGG	0.557000													109	81					0	0	0.323286	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564821	66564821	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:66564821A>G	ENST00000358653.5	+	8	1387	c.1270A>G	c.(1270-1272)Aaa>Gaa	p.K424E	CCDC102B_ENST00000584156.1_Intron|CCDC102B_ENST00000577772.1_3'UTR|CCDC102B_ENST00000360242.5_Intron|CCDC102B_ENST00000319445.6_Intron			Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	0										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				CTAGGATGTAAAATAACGTTC	0.378000													18	41					0	0	0.160694	0	0
FCRL5	83416	broad.mit.edu	37	1	157508979	157508979	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157508979G>T	ENST00000361835.3	-	7	1456	c.1299C>A	c.(1297-1299)gcC>gcA	p.A433A	FCRL5_ENST00000368190.3_Silent_p.A433A|FCRL5_ENST00000356953.4_Silent_p.A433A|FCRL5_ENST00000368191.3_Silent_p.A348A|FCRL5_ENST00000368189.3_Silent_p.A433A	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	433	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				AGAAGCTGATGGCCACTCCTC	0.577000													55	137					2.14255e-21	2.91413e-21	0.323286	1	0
DEFB122	245935	broad.mit.edu	37	20	30009273	30009273	+	RNA	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:30009273T>C	ENST00000433453.1	-	0	464					NR_045677.1																						CCCAGGAATCTACTGACATCA	0.378000													22	24					0	0	0.234183	0	0
MCPH1	79648	broad.mit.edu	37	8	6302908	6302908	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:6302908G>T	ENST00000344683.5	+	8	1741	c.1665G>T	c.(1663-1665)gcG>gcT	p.A555A	MCPH1_ENST00000522905.1_Silent_p.A507A|MCPH1_ENST00000519480.1_Silent_p.A555A	NM_024596.3	NP_078872.2	Q8NEM0	MCPH1_HUMAN	microcephalin 1	555						microtubule organizing center			AGPAT5/MCPH1(2)	central_nervous_system(1)|large_intestine(4)|skin(1)	6		Hepatocellular(245;0.0663)		Colorectal(4;0.0505)		TGAAAGAAGCGGTTGGTCTGA	0.423000													49	7					8.44121e-28	1.2343e-27	0.323286	1	0
COL5A2	1290	broad.mit.edu	37	2	189931133	189931133	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:189931133C>A	ENST00000374866.3	-	23	1820	c.1546G>T	c.(1546-1548)Ggg>Tgg	p.G516W		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	516					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent	p.G516W(1)		NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCCACTGGCCCTGGAGGACCA	0.463000													163	199					2.03423e-96	3.70154e-96	0.323286	1	0
KIR2DL1	3802	broad.mit.edu	37	19	55286890	55286890	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:55286890C>T	ENST00000336077.6	+	4	684	c.644C>T	c.(643-645)cCa>cTa	p.P215L	KIR2DL1_ENST00000291633.7_Missense_Mutation_p.P215L|CTB-61M7.1_ENST00000400864.3_RNA|KIR3DL1_ENST00000402254.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR2DL3_ENST00000434419.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	215					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		TCAAGTGACCCACTGCTTGTT	0.547000													259	186					0	0	0.323286	0	0
CENPE	1062	broad.mit.edu	37	4	104066267	104066267	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:104066267C>A	ENST00000265148.3	-	32	4886	c.4797G>T	c.(4795-4797)caG>caT	p.Q1599H	CENPE_ENST00000380026.3_Missense_Mutation_p.Q1574H	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1599					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		GAAGGGCCTCCTGTACTCTTT	0.328000													29	20					8.16721e-17	1.0452e-16	0.153744	1	0
FRZB	2487	broad.mit.edu	37	2	183699583	183699583	+	Missense_Mutation	SNP	C	C	A	rs138459633	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:183699583C>A	ENST00000295113.4	-	6	1580	c.971G>T	c.(970-972)cGc>cTc	p.R324L		NM_001463.3	NP_001454.2	Q92765	SFRP3_HUMAN	frizzled-related protein	324			R -> G (in hip OA susceptibility; has diminished ability to antagonize Wnt signaling, in vitro; dbSNP:rs7775).		brain development|cochlea morphogenesis|gonad development|mammary gland involution|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of hepatocyte differentiation|positive regulation of apoptosis|positive regulation of fat cell differentiation|skeletal system development|vasculature development|Wnt receptor signaling pathway	cytoplasm|extracellular space|membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(117;0.109)|Epithelial(96;0.231)			GATTTAGTTGCGTGCTTGCCG	0.428000													15	169					2.32078e-09	2.61839e-09	0.132662	1	0
RAB30	27314	broad.mit.edu	37	11	82708266	82708266	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:82708266C>A	ENST00000533486.1	-	3	377	c.93_splice	c.e3+1	p.Q31_splice	RAB30_ENST00000534141.1_Splice_Site_p.Q31_splice|RAB30_ENST00000260056.2_Splice_Site_p.Q31_splice|RAB30_ENST00000532548.1_Splice_Site_p.Q31_splice|RAB30_ENST00000525117.1_Splice_Site_p.Q31_splice|RAB30_ENST00000527633.1_Splice_Site_p.Q31_splice|RP11-659G9.3_ENST00000527550.1_RNA	NM_014488.3	NP_055303.2	Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	31					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						gttcccttacCTGAGTGAATC	0.473000													49	94					1.78197e-24	2.51768e-24	0.323286	1	0
LRRC16A	55604	broad.mit.edu	37	6	25610328	25610328	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:25610328G>T	ENST00000329474.6	+	36	4266	c.3898G>T	c.(3898-3900)Gtc>Ttc	p.V1300F		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	1300					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						TCTTCCACCTGTCCTGAAAAA	0.473000													50	150					8.44121e-28	1.2343e-27	0.323286	1	0
HYKK	123688	broad.mit.edu	37	15	78825798	78825798	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:78825798G>T	ENST00000388988.4	+	5	1021	c.908G>T	c.(907-909)gGt>gTt	p.G303V	HYKK_ENST00000569878.1_Missense_Mutation_p.G303V|HYKK_ENST00000408962.2_Intron|HYKK_ENST00000563233.1_Intron	NM_001013619.2	NP_001013641.2			hydroxylysine kinase																		GTAGAGAAGGGTGCTTTGTTT	0.443000													76	60					5.88917e-42	9.57415e-42	0.323286	1	0
GSDMA	284110	broad.mit.edu	37	17	38126822	38126822	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:38126822G>T	ENST00000301659.4	+	4	598	c.480G>T	c.(478-480)gtG>gtT	p.V160V		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	160					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						TGGAGACGGTGCAGGAGGTCA	0.572000													54	84					1.74971e-23	2.45419e-23	0.323286	1	0
LEPREL2	10536	broad.mit.edu	37	12	6946733	6946733	+	RNA	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:6946733A>G	ENST00000251761.8	+	0	1740				LEPREL2_ENST00000396725.2_RNA|LEPREL2_ENST00000606935.1_RNA	NM_014262.3	NP_055077.2			leprecan-like 2											breast(1)|cervix(1)|endometrium(2)|lung(6)	10						GCAGCGCCATAGAAGGTACGA	0.677000													10	30					0	0	0.069234	0	0
ATP7B	540	broad.mit.edu	37	13	52548913	52548913	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:52548913C>A	ENST00000242839.4	-	2	599	c.443G>T	c.(442-444)cGg>cTg	p.R148L	ATP7B_ENST00000344297.5_Missense_Mutation_p.R148L|ATP7B_ENST00000400370.3_Missense_Mutation_p.R148L|ATP7B_ENST00000418097.2_Missense_Mutation_p.R148L|ATP7B_ENST00000448424.2_Missense_Mutation_p.R148L|ATP7B_ENST00000400366.3_Missense_Mutation_p.R148L|ATP7B_ENST00000542656.1_Missense_Mutation_p.R116L	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	148	HMA 2.				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		GCCCTCCACCCGGAGCTTGAC	0.577000									Wilson disease				14	29					2.23348e-06	2.40595e-06	0.146539	1	0
ADPRHL2	54936	broad.mit.edu	37	1	36558942	36558942	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:36558942A>G	ENST00000373178.4	+	6	1077	c.1047A>G	c.(1045-1047)acA>acG	p.T349T		NM_017825.2	NP_060295.1	Q9NX46	ARHL2_HUMAN	ADP-ribosylhydrolase like 2	349						cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|pancreas(1)	8		Myeloproliferative disorder(586;0.0393)				ACGAGGAGACAGACATCCTGG	0.587000													30	53					0	0	0.163468	0	0
GRM7	2917	broad.mit.edu	37	3	7620674	7620674	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:7620674C>A	ENST00000486284.1	+	8	2355	c.2081C>A	c.(2080-2082)cCc>cAc	p.P694H	GRM7_ENST00000389336.4_Missense_Mutation_p.P694H|GRM7_ENST00000458641.2_3'UTR|GRM7_ENST00000357716.4_Missense_Mutation_p.P694H|GRM7_ENST00000403881.1_Missense_Mutation_p.P694H|GRM7_ENST00000402647.2_Missense_Mutation_p.P694H	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	694					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	GTAACAGCTCCCAGACTCATA	0.443000													45	21					2.13384e-23	2.98622e-23	0.323286	1	0
IGHV3-48	28424	broad.mit.edu	37	14	106993960	106993960	+	RNA	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:106993960A>C	ENST00000390624.2	-	0	283																											CTACTAATGTATGAAACCCAC	0.502000													269	336					0	0	0.323286	0	0
ABCB10	23456	broad.mit.edu	37	1	229676403	229676403	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:229676403T>C	ENST00000344517.4	-	5	1195	c.1153A>G	c.(1153-1155)Atg>Gtg	p.M385V		NM_012089.2	NP_036221.2	Q9NRK6	ABCBA_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 10	385	ABC transmembrane type-1.					integral to mitochondrial membrane|mitochondrial inner membrane	ATP binding|oligopeptide-transporting ATPase activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)	31	Breast(184;0.143)|Ovarian(103;0.249)	Prostate(94;0.167)				GCTAACTGCATTACATGGTCC	0.423000													49	86					0	0	0.323286	0	0
OR5T3	390154	broad.mit.edu	37	11	56020091	56020091	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56020091C>A	ENST00000303059.3	+	1	416	c.416C>A	c.(415-417)aCt>aAt	p.T139N		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					ACTTTTGGAACTACAGAATGT	0.393000													64	177					3.12118e-38	4.98263e-38	0.323286	1	0
ARHGEF12	23365	broad.mit.edu	37	11	120298878	120298878	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:120298878G>T	ENST00000397843.2	+	8	673	c.507G>T	c.(505-507)atG>atT	p.M169I	ARHGEF12_ENST00000356641.3_Missense_Mutation_p.M150I|ARHGEF12_ENST00000532993.1_Missense_Mutation_p.M66I	NM_015313.2	NP_056128.1	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	169					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(5)|endometrium(6)|kidney(5)|large_intestine(13)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(2)	61		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		TTGGACATATGTCTCCCATCA	0.507000			T	MLL	AML								184	111					2.63362e-95	4.78657e-95	0.323286	1	0
PSME4	23198	broad.mit.edu	37	2	54148067	54148067	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:54148067C>A	ENST00000404125.1	-	18	2276	c.2221G>T	c.(2221-2223)Ggt>Tgt	p.G741C	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	741					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			TCAAAGCCACCTGGCACACTG	0.393000													48	59					2.47907e-22	3.426e-22	0.323286	1	0
SIGLEC8	27181	broad.mit.edu	37	19	51961552	51961552	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51961552T>G	ENST00000321424.3	-	1	156	c.90A>C	c.(88-90)caA>caC	p.Q30H	SIGLEC8_ENST00000430817.1_Missense_Mutation_p.Q30H|SIGLEC8_ENST00000340550.5_Missense_Mutation_p.Q30H	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	30					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		GCTCCTGCACTTGCAGCAAGT	0.597000													12	170					0	0	0.132662	0	0
CP	1356	broad.mit.edu	37	3	148928163	148928163	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:148928163G>T	ENST00000264613.6	-	3	660	c.398C>A	c.(397-399)gCc>gAc	p.A133D		NM_000096.3	NP_000087.1	P00450	CERU_HUMAN	ceruloplasmin (ferroxidase)	133	F5/8 type A 1.|Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			breast(6)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	AGGGTAGATGGCCCCTAGGAA	0.373000													36	147					1.49673e-21	2.04382e-21	0.235728	1	0
ABCA4	24	broad.mit.edu	37	1	94512564	94512564	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:94512564C>T	ENST00000370225.3	-	19	2915	c.2829G>A	c.(2827-2829)cgG>cgA	p.R943R	ABCA4_ENST00000535735.1_Silent_p.R869R	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	943	ABC transporter 1.		R -> Q (in linkage disequilibrium with A- 863 in the European population; dbSNP:rs1801581).|R -> W (in STGD1 and FFM).		phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CCACAGCTGGCCGGCCACAGG	0.522000													6	397					0	0	0.278610	0	0
GPR85	54329	broad.mit.edu	37	7	112724050	112724050	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:112724050A>G	ENST00000501255.2	-	3	1350	c.727T>C	c.(727-729)Tgg>Cgg	p.W243R	GPR85_ENST00000424100.1_Missense_Mutation_p.W243R|GPR85_ENST00000297146.2_Missense_Mutation_p.W243R|GPR85_ENST00000449591.1_Missense_Mutation_p.W243R	NM_001146265.1|NM_001146266.1|NM_018970.6	NP_001139737.1|NP_001139738.1|NP_061843.3	P60893	GPR85_HUMAN	G protein-coupled receptor 85	243						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	17						CCTGCTAGCCAATTGGCAGCT	0.532000													32	63					0	0	0.323286	0	0
OR6C68	403284	broad.mit.edu	37	12	55887043	55887043	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55887043A>C	ENST00000379662.1	+	1	897	c.897A>C	c.(895-897)caA>caC	p.Q299H	RP11-110A12.2_ENST00000555138.1_RNA|OR6C68_ENST00000548615.1_Missense_Mutation_p.Q294H|RP11-110A12.2_ENST00000556750.1_RNA			A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C, member 68	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15						GGAATGAGCAAGTTAAACAAG	0.303000													7	73					0	0	0.307466	0	0
KCNT1	57582	broad.mit.edu	37	9	138669216	138669216	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:138669216G>A	ENST00000298480.5	+	21	2456	c.2382G>A	c.(2380-2382)aaG>aaA	p.K794K	KCNT1_ENST00000487664.1_Silent_p.K749K|KCNT1_ENST00000263604.3_Silent_p.K775K|KCNT1_ENST00000371757.2_Silent_p.K794K|KCNT1_ENST00000488444.2_Silent_p.K775K|KCNT1_ENST00000491806.2_Silent_p.K761K|KCNT1_ENST00000490355.2_Silent_p.K773K|KCNT1_ENST00000486577.2_Silent_p.K753K			B7ZVY4	B7ZVY4_HUMAN	potassium channel, subfamily T, member 1	794						membrane	binding|calcium-activated potassium channel activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.11e-07)|Epithelial(140;1.57e-06)|all cancers(34;9.22e-05)		AAGACGCCAAGGCCTACGGGT	0.607000													48	53					0	0	0.323286	0	0
PRSS23	11098	broad.mit.edu	37	11	86519020	86519020	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:86519020G>T	ENST00000280258.5	+	2	760	c.335G>T	c.(334-336)gGg>gTg	p.G112V	PRSS23_ENST00000441050.1_Missense_Mutation_p.G80V|PRSS23_ENST00000533902.2_Intron	NM_007173.4	NP_009104.1	O95084	PRS23_HUMAN	protease, serine, 23	112					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity	p.G112V(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				AGTGGAGATGGGGCCCAACAC	0.522000													32	46					9.65021e-13	1.1593e-12	0.153744	1	0
PCDHA7	56141	broad.mit.edu	37	5	140214162	140214162	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140214162G>T	ENST00000525929.1	+	1	194	c.194G>T	c.(193-195)cGg>cTg	p.R65L	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA7_ENST00000378125.3_Missense_Mutation_p.R65L|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCTGTTCCGGGCGGTGTGC	0.617000													33	56					3.11337e-16	3.95169e-16	0.173368	1	0
COL24A1	255631	broad.mit.edu	37	1	86529438	86529438	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:86529438A>T	ENST00000370571.2	-	8	2078	c.1712T>A	c.(1711-1713)cTc>cAc	p.L571H	COL24A1_ENST00000436319.1_Missense_Mutation_p.L571H	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	571	Collagen-like 2.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATGTCCTTTGAGACCCTGTAA	0.383000													13	141					0	0	0.146539	0	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10218214	10218214	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:10218214G>T	ENST00000428358.1	+	3	395	c.223G>T	c.(223-225)Gca>Tca	p.A75S	PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.A75S|PPAN_ENST00000253107.7_Missense_Mutation_p.A75S|PPAN_ENST00000393793.1_Missense_Mutation_p.A22S|PPAN_ENST00000556468.1_Missense_Mutation_p.A75S	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		75	Brix.				RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			GGACTGCGTGGCAGTGGCTGG	0.483000													13	13					5.45727e-16	6.90971e-16	0.134883	1	0
LMTK3	114783	broad.mit.edu	37	19	49001621	49001621	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:49001621C>G	ENST00000600059.1	-	11	2932	c.2705G>C	c.(2704-2706)gGc>gCc	p.G902A	LMTK3_ENST00000270238.3_Missense_Mutation_p.G931A					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CCTGTTCAGGCCCGGGACTTT	0.652000													7	8					0	0	0.248553	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74835229	74835229	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:74835229T>C	ENST00000370895.1	+	18	1965	c.1930T>C	c.(1930-1932)Tca>Cca	p.S644P	RP11-439H8.4_ENST00000415549.2_RNA|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.S644P|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.S644P|TNNI3K_ENST00000326637.3_Missense_Mutation_p.S543P|TNNI3K_ENST00000370891.2_Missense_Mutation_p.S644P			Q59H18	TNI3K_HUMAN		543	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										TCAATACATATCAGGGGGTTC	0.458000													128	145					0	0	0.323286	0	0
GPR12	2835	broad.mit.edu	37	13	27332968	27332968	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:27332968C>A	ENST00000405846.3	-	2	1218	c.997G>T	c.(997-999)Gat>Tat	p.D333Y	GPR12_ENST00000381436.2_Missense_Mutation_p.D333Y	NM_005288.3	NP_005279.1	P47775	GPR12_HUMAN	G protein-coupled receptor 12	333						integral to plasma membrane				endometrium(7)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		TGCTACACATCACTGGGCGAG	0.537000													5	11					2.0095e-06	2.16919e-06	0.248553	1	0
SH3PXD2B	285590	broad.mit.edu	37	5	171766420	171766420	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:171766420C>T	ENST00000311601.5	-	13	1859	c.1689G>A	c.(1687-1689)atG>atA	p.M563I	SH3PXD2B_ENST00000519643.1_Intron	NM_001017995.2	NP_001017995.1	A1X283	SPD2B_HUMAN	SH3 and PX domains 2B	563					adipose tissue development|bone development|cell communication|cell differentiation|eye development|heart development|podosome assembly	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-5-phosphate binding|SH2 domain binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(12)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0207)|all_neural(177;0.0625)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TGGCTGGCATCATCGGCAAAA	0.637000													20	23					0	0	0.309145	0	0
GPC5	2262	broad.mit.edu	37	13	92346038	92346038	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:92346038G>C	ENST00000377067.3	+	3	1295	c.923G>C	c.(922-924)gGa>gCa	p.G308A		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	308						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GCAATGCATGGAACATACGAC	0.478000													33	278					0	0	0.225048	0	0
NFASC	23114	broad.mit.edu	37	1	204945843	204945843	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:204945843A>T	ENST00000367172.4	+	16	2079	c.1751A>T	c.(1750-1752)gAg>gTg	p.E584V	NFASC_ENST00000404907.1_Missense_Mutation_p.E595V|NFASC_ENST00000367171.4_Missense_Mutation_p.E584V|NFASC_ENST00000403080.1_Missense_Mutation_p.E584V|NFASC_ENST00000338586.6_Missense_Mutation_p.E584V|NFASC_ENST00000367170.4_Missense_Mutation_p.E584V|NFASC_ENST00000339876.6_Missense_Mutation_p.E584V|NFASC_ENST00000360049.4_Missense_Mutation_p.E595V|NFASC_ENST00000367169.4_Missense_Mutation_p.E584V|NFASC_ENST00000513543.1_Missense_Mutation_p.E595V|NFASC_ENST00000539706.1_Missense_Mutation_p.E595V|NFASC_ENST00000401399.1_Missense_Mutation_p.E584V|NFASC_ENST00000404076.1_Missense_Mutation_p.E578V|NFASC_ENST00000338515.6_Missense_Mutation_p.E584V			O94856	NFASC_HUMAN	neurofascin	584	Ig-like C2-type 6.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			GGGGTGGCAGAGCGGGACCAG	0.607000													139	453					0	0	0.323286	0	0
IVD	3712	broad.mit.edu	37	15	40699843	40699843	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:40699843C>A	ENST00000249760.2	+	2	494	c.151C>A	c.(151-153)Cag>Aag	p.Q51K	IVD_ENST00000479013.2_Intron|IVD_ENST00000490194.1_3'UTR|IVD_ENST00000487418.2_Missense_Mutation_p.Q54K	NM_002225.3	NP_002216.2	P26440	IVD_HUMAN	isovaleryl-CoA dehydrogenase	51					leucine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|isovaleryl-CoA dehydrogenase activity			kidney(1)|lung(5)|ovary(2)|prostate(1)	9		all_cancers(109;1.19e-18)|all_epithelial(112;1.52e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.65e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0808)		TTAGCTTCGTCAGACCATGGC	0.527000													25	41					3.73808e-20	5.01596e-20	0.324025	1	0
POTEA	340441	broad.mit.edu	37	8	43211974	43211974	+	RNA	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:43211974A>G	ENST00000522175.2	+	0	1297							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A									p.H478R(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						AAAAATAGCCACTATGAGCAA	0.368000													19	52					0	0	0.279207	0	0
HTR1B	3351	broad.mit.edu	37	6	78172293	78172293	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:78172293G>T	ENST00000369947.2	-	1	1197	c.828C>A	c.(826-828)gaC>gaA	p.D276E		NM_000863.1	NP_000854.1	P28222	5HT1B_HUMAN	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	276					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cAMP biosynthetic process|synaptic transmission	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(2)|upper_aerodigestive_tract(2)	25		all_cancers(76;0.0867)|Acute lymphoblastic leukemia(125;0.00119)|all_hematologic(105;0.0332)		BRCA - Breast invasive adenocarcinoma(397;0.205)	Almotriptan(DB00918)|Dexfenfluramine(DB01191)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Pindolol(DB00960)|Propranolol(DB00571)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Venlafaxine(DB00285)|Zolmitriptan(DB00315)	CGCTGGGCACGTCGGGAACCC	0.607000													69	40					8.73484e-25	1.23694e-24	0.323286	1	0
BCOR	54880	broad.mit.edu	37	X	39932963	39932963	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:39932963G>A	ENST00000342274.4	-	4	1998	c.1636C>T	c.(1636-1638)Cgc>Tgc	p.R546C	BCOR_ENST00000378444.4_Missense_Mutation_p.R546C|BCOR_ENST00000378455.4_Missense_Mutation_p.R546C|BCOR_ENST00000397354.3_Missense_Mutation_p.R546C	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	546					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						CCGCCCATGCGCGGGCATGAT	0.582000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						28	28					0	0	0.173368	0	0
NXPH2	11249	broad.mit.edu	37	2	139428608	139428608	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:139428608G>A	ENST00000272641.3	-	2	785	c.679C>T	c.(679-681)Ccc>Tcc	p.P227S		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	227	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		ACCTTGAAGGGCTTGGAGCAC	0.468000													131	78					0	0	0.323286	0	0
ASNS	440	broad.mit.edu	37	7	97481701	97481701	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:97481701C>A	ENST00000175506.4	-	14	2084	c.1556G>T	c.(1555-1557)cGt>cTt	p.R519L	ASNS_ENST00000455086.1_Missense_Mutation_p.R436L|ASNS_ENST00000444334.1_Missense_Mutation_p.R498L|ASNS_ENST00000394309.3_Missense_Mutation_p.R519L|ASNS_ENST00000437628.1_Missense_Mutation_p.R436L|ASNS_ENST00000394308.3_Missense_Mutation_p.R519L|ASNS_ENST00000422745.1_Missense_Mutation_p.R498L	NM_183356.3	NP_899199.2	P08243	ASNS_HUMAN	asparagine synthetase (glutamine-hydrolyzing)	519	Asparagine synthetase.				cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding			ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	AAAGACTTGACGGTAGTAATA	0.478000													37	136					2.45108e-15	3.06831e-15	0.268233	1	0
FAM83B	222584	broad.mit.edu	37	6	54804952	54804952	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:54804952G>C	ENST00000306858.7	+	5	1299	c.1183G>C	c.(1183-1185)Gaa>Caa	p.E395Q		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	395										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					GGAACAGCCAGAAACAGTGCC	0.418000													50	161					0	0	0.323286	0	0
ZNF214	7761	broad.mit.edu	37	11	7024026	7024026	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:7024026C>A	ENST00000278314.4	-	2	356	c.41G>T	c.(40-42)tGg>tTg	p.W14L	ZNF214_ENST00000531083.1_5'UTR|ZNF214_ENST00000536068.1_Missense_Mutation_p.W14L	NM_013249.2	NP_037381.2	Q9UL59	ZN214_HUMAN	zinc finger protein 214	14	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		CCACTCCTCCCATGTAAAAAT	0.388000													81	58					6.11987e-43	1.00229e-42	0.323286	1	0
CA10	56934	broad.mit.edu	37	17	49726546	49726546	+	Missense_Mutation	SNP	T	T	C	rs71713990		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:49726546T>C	ENST00000451037.2	-	6	1571	c.631A>G	c.(631-633)Aaa>Gaa	p.K211E	CA10_ENST00000340813.6_Missense_Mutation_p.K217E|CA10_ENST00000570565.1_Missense_Mutation_p.K136E|CA10_ENST00000571918.1_5'UTR|CA10_ENST00000442502.2_Missense_Mutation_p.K211E|CA10_ENST00000285273.4_Missense_Mutation_p.K211E	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	211					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			AACTTACTTTTATATGTTATT	0.388000													21	45					0	0	0.234183	0	0
GALNT13	114805	broad.mit.edu	37	2	155295170	155295170	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:155295170A>C	ENST00000392825.3	+	12	2029	c.1462A>C	c.(1462-1464)Aat>Cat	p.N488H	GALNT13_ENST00000409237.1_Missense_Mutation_p.N488H|AC009227.2_ENST00000434635.1_RNA|GALNT13_ENST00000487047.1_3'UTR	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	488	Ricin B-type lectin.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						TTCTAGACTCAATGGACCTGT	0.318000													12	131					0	0	0.119110	0	0
ARAP1	116985	broad.mit.edu	37	11	72398509	72398509	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:72398509C>A	ENST00000359373.5	-	32	4978	c.4127G>T	c.(4126-4128)tGg>tTg	p.W1376L	ARAP1_ENST00000393605.3_Missense_Mutation_p.W1147L|ARAP1_ENST00000455638.2_Missense_Mutation_p.W1376L|ARAP1_ENST00000429686.1_Missense_Mutation_p.W1070L|ARAP1_ENST00000393609.3_Missense_Mutation_p.W1387L|ARAP1_ENST00000495878.1_5'UTR|ARAP1_ENST00000334211.8_Missense_Mutation_p.W1142L|ARAP1-AS1_ENST00000542022.1_RNA|ARAP1_ENST00000426523.1_Missense_Mutation_p.W1131L			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	1387	PH 4.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						GGTAGCGAACCACTCCCGGAG	0.582000													40	134					8.01111e-26	1.14757e-25	0.290176	1	0
KBTBD8	84541	broad.mit.edu	37	3	67054199	67054199	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:67054199C>T	ENST00000295568.4	+	3	861	c.730C>T	c.(730-732)Cca>Tca	p.P244S	KBTBD8_ENST00000417314.2_Missense_Mutation_p.P270S|KBTBD8_ENST00000469661.1_3'UTR|KBTBD8_ENST00000460576.1_Intron	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	270	BACK.									breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		AGAAAAGGGACCATCCAACAC	0.423000													61	131					0	0	0.323286	0	0
COL19A1	1310	broad.mit.edu	37	6	70745795	70745795	+	Splice_Site	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:70745795G>A	ENST00000322773.4	+	14	1236		c.e14-1			NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1						cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						ATCTATTTTAGGGAGATACAG	0.313000													24	44					0	0	0.125774	0	0
SPARC	6678	broad.mit.edu	37	5	151049241	151049241	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:151049241G>A	ENST00000231061.4	-	6	748	c.435C>T	c.(433-435)taC>taT	p.Y145Y		NM_003118.3	NP_003109.1	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich (osteonectin)	145	Kazal-like.				ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(3)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	AAGGCCCGATGTAGTCCAGGT	0.572000													27	42					0	0	0.144211	0	0
HNRNPA1	3178	broad.mit.edu	37	12	54676198	54676198	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:54676198A>G	ENST00000546500.1	+	5	1126	c.511A>G	c.(511-513)Aat>Gat	p.N171D	RP11-968A15.8_ENST00000553061.1_RNA|HNRNPA1_ENST00000330752.8_Missense_Mutation_p.N171D|HNRNPA1_ENST00000547276.1_Missense_Mutation_p.N171D|HNRNPA1_ENST00000340913.6_Missense_Mutation_p.N171D			P09651	ROA1_HUMAN	heterogeneous nuclear ribonucleoprotein A1	171	Globular B domain.|RRM 2.				interspecies interaction between organisms|mRNA transport|nuclear import	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|single-stranded DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20						CCATACTGTGAATGGCCACAA	0.383000													6	2					0	0	0.248553	0	0
SLC2A5	6518	broad.mit.edu	37	1	9097801	9097801	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:9097801G>T	ENST00000377424.4	-	12	1529	c.1350C>A	c.(1348-1350)ctC>ctA	p.L450L	SLC2A5_ENST00000535586.1_Silent_p.L335L|SLC2A5_ENST00000536305.1_Silent_p.L391L	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	450					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTGGTGAGGAGGCAGATCA	0.552000													29	18					3.1745e-13	3.8434e-13	0.134883	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18776831	18776831	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:18776831G>T	ENST00000380548.4	+	19	2943	c.2604G>T	c.(2602-2604)aaG>aaT	p.K868N		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	868	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding	p.K868N(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCGCCAGGAAGGTCTACATAC	0.672000													14	9					1.33834e-09	1.51548e-09	0.189662	1	0
OR4C12	283093	broad.mit.edu	37	11	50003201	50003201	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:50003201C>A	ENST00000335238.4	-	1	870	c.837G>T	c.(835-837)atG>atT	p.M279I		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	279					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						CGGGATTTAACATTGGGACCA	0.383000													87	149					9.01214e-43	1.47363e-42	0.323286	1	0
LAMA2	3908	broad.mit.edu	37	6	129618940	129618940	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:129618940T>C	ENST00000421865.2	+	21	3016	c.2967T>C	c.(2965-2967)ccT>ccC	p.P989P		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	989	Laminin EGF-like 10.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGTGCCAACCTGGAGTCACAG	0.478000													24	43					0	0	0.309145	0	0
DDX39B	7919	broad.mit.edu	37	6	31498927	31498927	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31498927A>G	ENST00000417556.2	-	10	1700	c.1070T>C	c.(1069-1071)gTg>gCg	p.V357A	DDX39B_ENST00000458640.1_Missense_Mutation_p.V342A|ATP6V1G2-DDX39B_ENST00000376185.1_3'UTR|DDX39B_ENST00000396172.1_Missense_Mutation_p.V342A|DDX39B_ENST00000376177.2_Missense_Mutation_p.V342A|DDX39B_ENST00000415382.2_Missense_Mutation_p.V264A			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	342	Helicase C-terminal.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						GTTGGTAGCCACAAGAATTCG	0.433000													97	70					0	0	0.323286	0	0
ZFYVE19	84936	broad.mit.edu	37	15	41102329	41102329	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:41102329A>C	ENST00000355341.4	+	5	1133	c.632A>C	c.(631-633)cAg>cCg	p.Q211P	ZFYVE19_ENST00000570108.1_Missense_Mutation_p.Q188P|ZFYVE19_ENST00000336455.5_Missense_Mutation_p.Q201P|ZFYVE19_ENST00000564258.1_Missense_Mutation_p.Q36P|ZFYVE19_ENST00000299173.10_Missense_Mutation_p.Q211P	NM_001077268.1	NP_001070736.1	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	211							zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	9		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GATGAACGTCAGGGTTCCATC	0.582000													23	22					0	0	0.264190	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73316238	73316238	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:73316238G>A	ENST00000258098.6	-	2	877	c.637C>T	c.(637-639)Cca>Tca	p.P213S	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	213					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						GCGCTGCTTGGGAGGATGGCA	0.557000													41	71					0	0	0.323286	0	0
SLC25A39	51629	broad.mit.edu	37	17	42398533	42398533	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:42398533G>T	ENST00000225308.8	-	8	734	c.560C>A	c.(559-561)tCg>tAg	p.S187*	SLC25A39_ENST00000537904.2_Nonsense_Mutation_p.S172*|SLC25A39_ENST00000377095.5_Nonsense_Mutation_p.S195*|SLC25A39_ENST00000586016.1_Nonsense_Mutation_p.S63*|SLC25A39_ENST00000590194.1_Nonsense_Mutation_p.S187*	NM_016016.2	NP_057100.1	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39	195					heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CTCCCGGTACGACACATGCTG	0.637000													6	11					0.000157383	0.000164723	0.278610	1	0
WNK4	65266	broad.mit.edu	37	17	40933114	40933114	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:40933114G>A	ENST00000246914.5	+	1	419	c.398G>A	c.(397-399)gGc>gAc	p.G133D		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	133					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TCTGCAGTGGGCCCGGGGTCC	0.682000													5	38					0	0	0.184627	0	0
EVC	2121	broad.mit.edu	37	4	5812716	5812716	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:5812716G>T	ENST00000382674.2	+	21	3115	c.2931G>T	c.(2929-2931)ggG>ggT	p.G977G	EVC_ENST00000264956.6_Silent_p.G977G			P57679	EVC_HUMAN	Ellis van Creveld syndrome	977					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				GTGAAGCTGGGGACAGTGGGA	0.478000													26	45					4.4194e-11	5.16681e-11	0.173368	1	0
KHDRBS2	202559	broad.mit.edu	37	6	62390939	62390939	+	Missense_Mutation	SNP	A	A	G	rs111625311		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:62390939A>G	ENST00000281156.4	-	9	1257	c.979T>C	c.(979-981)Tct>Cct	p.S327P	RP1-240B8.3_ENST00000511849.2_RNA	NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	327					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TTCAAGCTAGAGCGGGTTGTG	0.473000													30	72					0	0	0.183431	0	0
RIOK2	55781	broad.mit.edu	37	5	96513554	96513554	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:96513554T>A	ENST00000283109.3	-	3	274		c.e3-2		RIOK2_ENST00000508447.1_Splice_Site|CTD-2215E18.1_ENST00000509481.1_Intron	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2								ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		CCTGGACAGCTAGACAAAAAT	0.363000													50	60					0	0	0.323286	0	0
CACNA1C	775	broad.mit.edu	37	12	2721178	2721178	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:2721178A>C	ENST00000480911.1	+	29	3852	c.3827A>C	c.(3826-3828)aAg>aCg	p.K1276T	CACNA1C_ENST00000399637.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399597.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000344100.3_Splice_Site_p.K1276_splice|CACNA1C_ENST00000327702.7_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399601.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399621.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399644.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399641.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399629.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399617.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399638.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000402845.3_Splice_Site_p.K1276_splice|CACNA1C_ENST00000406454.3_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399591.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399649.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399655.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399634.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000347598.4_Splice_Site_p.K1296_splice|CACNA1C_ENST00000399606.1_Splice_Site_p.K1296_splice|CACNA1C_ENST00000335762.5_Splice_Site_p.K1301_splice|CACNA1C_ENST00000399595.1_Splice_Site_p.K1276_splice|CACNA1C_ENST00000399603.1_Splice_Site_p.K1276_splice			Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1296					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	TTCAAACCCAAGGTAGGCCTC	0.532000													16	201					0	0	0.146539	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222248	140222248	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140222248G>C	ENST00000531613.1	+	1	1342	c.1342G>C	c.(1342-1344)Gtg>Ctg	p.V448L	PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.V448L|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCCGACGTGAACGACAA	0.657000													25	52					0	0	0.225048	0	0
TTBK1	84630	broad.mit.edu	37	6	43251477	43251477	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:43251477G>T	ENST00000259750.4	+	14	3082	c.2999G>T	c.(2998-3000)gGg>gTg	p.G1000V		NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	1000						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			GCCCTGTCTGGGGCCCCCCGG	0.706000													21	57					5.35356e-11	6.23307e-11	0.264190	1	0
FBXL7	23194	broad.mit.edu	37	5	15928113	15928113	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:15928113C>A	ENST00000504595.1	+	3	723	c.242C>A	c.(241-243)aCc>aAc	p.T81N	FBXL7_ENST00000329673.7_Missense_Mutation_p.T69N|FBXL7_ENST00000510662.1_Missense_Mutation_p.T34N	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	81					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						TCCTCCATCACCGGGGAGACG	0.652000													23	59					1.64293e-13	2.00085e-13	0.279207	1	0
COL3A1	1281	broad.mit.edu	37	2	189868724	189868724	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:189868724C>A	ENST00000304636.3	+	39	2848	c.2678C>A	c.(2677-2679)cCa>cAa	p.P893Q	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	893	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.P893L(1)		NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCAGGACCCCCAGGTCCCAGC	0.438000													14	23					1.49906e-05	1.59102e-05	0.119110	1	0
OR5T1	390155	broad.mit.edu	37	11	56043691	56043691	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56043691A>G	ENST00000313033.2	+	1	663	c.577A>G	c.(577-579)Atg>Gtg	p.M193V		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	193					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					CTTTTGTAATATGCCTCCTCT	0.393000													258	147					0	0	0.323286	0	0
PDHA2	5161	broad.mit.edu	37	4	96761292	96761292	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:96761292C>A	ENST00000295266.4	+	0	54					NM_005390.4	NP_005381.1	P29803	ODPAT_HUMAN	pyruvate dehydrogenase (lipoamide) alpha 2						glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(23)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	46		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	TACAGCACTCCGTGAAGAATA	0.622000													7	13					1.12685e-05	1.20009e-05	0.307466	1	0
NUFIP2	57532	broad.mit.edu	37	17	27613887	27613887	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:27613887C>A	ENST00000225388.4	-	2	1183	c.1125G>T	c.(1123-1125)gtG>gtT	p.V375V	NUFIP2_ENST00000579665.1_Intron	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	375	Ser-rich.					nucleus|polysomal ribosome	protein binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			AAGTTGGTGACACAGAAGAGT	0.403000													48	83					6.27289e-28	9.18107e-28	0.323286	1	0
PCDHGA6	56109	broad.mit.edu	37	5	140754020	140754020	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140754020G>T	ENST00000517434.1	+	1	370	c.370G>T	c.(370-372)Gtg>Ttg	p.V124L	PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGGAAATAGTGGACATTAA	0.458000													33	44					6.84511e-11	7.95471e-11	0.183431	1	0
RPS6KB2	6199	broad.mit.edu	37	11	67200239	67200239	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:67200239G>T	ENST00000312629.5	+	7	592	c.547G>T	c.(547-549)Ggc>Tgc	p.G183C	AP003419.16_ENST00000535922.1_RNA|RPS6KB2_ENST00000524814.1_3'UTR|RPS6KB2_ENST00000539188.1_3'UTR	NM_003952.2	NP_003943.2	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 2	183	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|salivary_gland(1)|stomach(2)	25			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			GCTGGCCCTGGGCCATCTCCA	0.622000													28	44					2.09667e-21	2.85298e-21	0.193644	1	0
LINGO4	339398	broad.mit.edu	37	1	151773761	151773761	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:151773761C>T	ENST00000368820.3	-	2	2357	c.1420G>A	c.(1420-1422)Gtg>Atg	p.V474M		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	474	Ig-like C2-type.					integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CGTAGCTGCACTGAGCGGATC	0.612000													113	245					0	0	0.323286	0	0
KRT76	51350	broad.mit.edu	37	12	53165751	53165751	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:53165751C>A	ENST00000332411.2	-	6	1220	c.1167G>T	c.(1165-1167)agG>agT	p.R389S		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	389	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CATCCCCATGCCTGCCAGCTG	0.507000													36	83					2.40579e-17	3.09673e-17	0.235728	1	0
HECW1	23072	broad.mit.edu	37	7	43484518	43484518	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:43484518G>T	ENST00000395891.1	+	11	2352	c.1747G>T	c.(1747-1749)Gac>Tac	p.D583Y	HECW1_ENST00000453890.1_Missense_Mutation_p.D583Y	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	583					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						AGAGGAGGAGGACGGCGCGGA	0.697000													16	21					2.35188e-11	2.76529e-11	0.175082	1	0
OR10K1	391109	broad.mit.edu	37	1	158436204	158436204	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158436204T>G	ENST00000289451.2	+	1	933	c.853T>G	c.(853-855)Ttc>Gtc	p.F285V		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TACCCCATTGTTCAATCCAAT	0.383000													94	207					0	0	0.323286	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793318	65793318	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:65793318G>T	ENST00000312106.5	-	1	670	c.533C>A	c.(532-534)tCc>tAc	p.S178Y		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	178	His-rich.				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						GGGGAGGTAGGACCCACCATG	0.587000													19	31					7.88262e-20	1.05226e-19	0.279207	1	0
COX8C	341947	broad.mit.edu	37	14	93813686	93813686	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:93813686C>G	ENST00000342144.2	+	1	150	c.72C>G	c.(70-72)ccC>ccG	p.P24P	UNC79_ENST00000256339.4_Intron	NM_182971.2	NP_892016.1	Q7Z4L0	COX8C_HUMAN	cytochrome c oxidase subunit VIIIC	24						integral to membrane|mitochondrial inner membrane	cytochrome-c oxidase activity			large_intestine(1)|lung(1)|prostate(2)|skin(1)	5		all_cancers(154;0.083)		Epithelial(152;0.176)|all cancers(159;0.197)|COAD - Colon adenocarcinoma(157;0.202)		GCCTGCAGCCCGCTCCCCGCT	0.736000													5	8					0	0	0.249174	0	0
ZNF492	57615	broad.mit.edu	37	19	22847837	22847837	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:22847837A>T	ENST00000456783.2	+	4	1610	c.1366A>T	c.(1366-1368)Aaa>Taa	p.K456*		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				AGAATGTGGCAAAGCTTTTAA	0.388000													26	107					0	0	0.153744	0	0
MAPT	4137	broad.mit.edu	37	17	44073970	44073970	+	Missense_Mutation	SNP	G	G	T	rs141636979		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:44073970G>T	ENST00000344290.5	+	11	2089	c.1767G>T	c.(1765-1767)aaG>aaT	p.K589N	MAPT_ENST00000340799.5_Missense_Mutation_p.K225N|MAPT_ENST00000262410.5_Missense_Mutation_p.K571N|MAPT_ENST00000431008.3_Missense_Mutation_p.K254N|MAPT_ENST00000347967.5_Missense_Mutation_p.K160N|MAPT_ENST00000570299.1_3'UTR|MAPT_ENST00000571987.1_Missense_Mutation_p.K571N|MAPT_ENST00000535772.1_Missense_Mutation_p.K254N|MAPT_ENST00000446361.3_Missense_Mutation_p.K196N|MAPT_ENST00000351559.5_Missense_Mutation_p.K254N|MAPT_ENST00000334239.8_Missense_Mutation_p.K196N|MAPT_ENST00000415613.2_Missense_Mutation_p.K589N|MAPT_ENST00000420682.2_Missense_Mutation_p.K225N|MAPT_ENST00000574436.1_Missense_Mutation_p.K254N|MAPT_ENST00000576518.1_Missense_Mutation_p.K185N	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	571			G -> V (in FTD).		cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				CAGACCTGAAGAATGTCAAGT	0.652000													20	32					2.79863e-10	3.20895e-10	0.309145	1	0
ZNF318	24149	broad.mit.edu	37	6	43308232	43308232	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:43308232C>A	ENST00000361428.2	-	10	3581	c.3504G>T	c.(3502-3504)gtG>gtT	p.V1168V	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1168					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			GGTTTTCATCCACATATTTCT	0.443000													7	31					0.00621372	0.00636372	0.058154	1	0
COL17A1	1308	broad.mit.edu	37	10	105799241	105799241	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:105799241G>C	ENST00000353479.5	-	43	3148	c.2858C>G	c.(2857-2859)cCa>cGa	p.P953R	COL17A1_ENST00000369733.3_Intron	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	953	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		AGGTGGGCCTGGTGGTCCCTG	0.612000													94	4					0	0	0.323286	0	0
NID2	22795	broad.mit.edu	37	14	52520549	52520549	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:52520549T>G	ENST00000216286.5	-	5	1176	c.1177A>C	c.(1177-1179)Agc>Cgc	p.S393R	NID2_ENST00000541773.1_Missense_Mutation_p.S340R	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	393						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GGAGCTGGGCTTCTGGTCTCT	0.562000													17	249					0	0	0.175082	0	0
PLCL1	5334	broad.mit.edu	37	2	198950365	198950365	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:198950365C>T	ENST00000428675.1	+	2	2522	c.2124C>T	c.(2122-2124)agC>agT	p.S708S	PLCL1_ENST00000437704.2_Silent_p.S610S	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	708	C2.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CTTACTTCAGCGCAAATACAA	0.473000													28	290					0	0	0.125774	0	0
LRP1B	53353	broad.mit.edu	37	2	141528456	141528456	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:141528456A>T	ENST00000389484.3	-	34	6591	c.5620T>A	c.(5620-5622)Tgt>Agt	p.C1874S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1874	EGF-like 4.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATACCTTGACATGACATACGG	0.368000										TSP Lung(27;0.18)			61	156					0	0	0.323286	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329046	88329046	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:88329046G>T	ENST00000325089.6	+	2	1622	c.1403G>T	c.(1402-1404)aGg>aTg	p.R468M	SLITRK5_ENST00000400028.3_Missense_Mutation_p.R227M	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	468						integral to membrane		p.R468M(1)		breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					AATGGCAACAGGATCGAGAGG	0.552000													38	80					2.45108e-15	3.06831e-15	0.268233	1	0
PTEN	5728	broad.mit.edu	37	10	89692790	89692790	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:89692790G>T	ENST00000371953.3	+	5	1631	c.274G>T	c.(274-276)Gac>Tac	p.D92Y		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	92	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(5)|p.R55fs*1(5)|p.D92H(4)|p.Y27fs*1(2)|p.D92N(2)|p.D92Y(1)|p.Q87_P96del(1)|p.N82_P95del(1)|p.F56fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TCCTTTTGAAGACCATAACCC	0.333000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			48	71					5.22555e-25	7.41684e-25	0.323286	1	0
LGI2	55203	broad.mit.edu	37	4	25014122	25014122	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:25014122C>A	ENST00000382114.4	-	7	841		c.e7-1			NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2							extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				ACAACAAAATCTGGGGATGGG	0.458000													38	44					2.26627e-22	3.13893e-22	0.257332	1	0
PARS2	25973	broad.mit.edu	37	1	55224317	55224317	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:55224317G>C	ENST00000371279.3	-	2	600	c.518C>G	c.(517-519)tCc>tGc	p.S173C		NM_152268.3	NP_689481.2	Q7L3T8	SYPM_HUMAN	prolyl-tRNA synthetase 2, mitochondrial (putative)	173					prolyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|proline-tRNA ligase activity			breast(1)|endometrium(3)|kidney(2)|lung(4)|ovary(2)|prostate(2)|skin(1)	15					L-Proline(DB00172)	CTGCTTGTAGGACAGTTTCTT	0.522000													92	189					0	0	0.323286	0	0
CPAMD8	27151	broad.mit.edu	37	19	17039981	17039981	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:17039981C>T	ENST00000443236.1	-	24	3087	c.3056G>A	c.(3055-3057)cGc>cAc	p.R1019H		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	972						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CACATCAAAGCGGGTGAGGCG	0.587000													22	41					0	0	0.235728	0	0
KLHL40	131377	broad.mit.edu	37	3	42727276	42727276	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:42727276C>T	ENST00000287777.4	+	1	266	c.166C>T	c.(166-168)Ccc>Tcc	p.P56S		NM_152393.2	NP_689606.2			kelch-like family member 40																		CGCCTGCAGCCCCTACTTCCG	0.692000													5	3					0	0	0.248553	0	0
RNF182	221687	broad.mit.edu	37	6	13977560	13977560	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:13977560G>T	ENST00000488300.1	+	3	733	c.210G>T	c.(208-210)gaG>gaT	p.E70D	RNF182_ENST00000537388.1_Missense_Mutation_p.E70D|RNF182_ENST00000537663.1_Missense_Mutation_p.E70D|RNF182_ENST00000544682.1_Missense_Mutation_p.E70D	NM_152737.3	NP_689950.1	Q8N6D2	RN182_HUMAN	ring finger protein 182	70						cytoplasm|integral to membrane|intracellular membrane-bounded organelle	protein binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|large_intestine(7)|liver(2)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15	Breast(50;0.00405)|Ovarian(93;0.0964)	all_hematologic(90;0.135)	Epithelial(50;0.195)			GCAGGTTTGAGACGTGCCTGC	0.488000													69	195					6.20995e-33	9.56827e-33	0.323286	1	0
WISP3	8838	broad.mit.edu	37	6	112386072	112386072	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:112386072C>T	ENST00000361714.1	+	3	560	c.515C>T	c.(514-516)cCt>cTt	p.P172L	WISP3_ENST00000409166.1_5'UTR|WISP3_ENST00000230529.5_Missense_Mutation_p.P154L|WISP3_ENST00000368663.3_Missense_Mutation_p.P131L|WISP3_ENST00000368666.2_Missense_Mutation_p.P154L|WISP3_ENST00000604763.1_Missense_Mutation_p.P154L			O95389	WISP3_HUMAN	WNT1 inducible signaling pathway protein 3	154					cell-cell signaling|regulation of cell growth|signal transduction	extracellular region|soluble fraction	growth factor activity|insulin-like growth factor binding			breast(1)|central_nervous_system(1)|large_intestine(3)|lung(7)|prostate(1)	13		all_cancers(87;0.000196)|Acute lymphoblastic leukemia(125;1.18e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0283)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0827)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		GGATGCACACCTCTGTTCATA	0.507000													116	263					0	0	0.323286	0	0
OR8K3	219473	broad.mit.edu	37	11	56086192	56086192	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56086192C>A	ENST00000312711.1	+	1	410	c.410C>A	c.(409-411)tCa>tAa	p.S137*		NM_001005202.1	NP_001005202.1	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K, member 3	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S137*(1)		central_nervous_system(2)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|ovary(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	40	Esophageal squamous(21;0.00448)					GTAATCATGTCACGAAGGGTA	0.413000													44	123					5.47352e-35	8.55272e-35	0.323286	1	0
MANEA	79694	broad.mit.edu	37	6	96034506	96034506	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:96034506G>T	ENST00000358812.4	+	2	325	c.191G>T	c.(190-192)aGt>aTt	p.S64I	MANEA_ENST00000369293.1_Missense_Mutation_p.S64I	NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	64	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		TTCCAAAAGAGTGACAGAATC	0.358000													64	47					2.05175e-36	3.23867e-36	0.323286	1	0
ALDH16A1	126133	broad.mit.edu	37	19	49967889	49967889	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:49967889G>T	ENST00000293350.4	+	12	1601	c.1437_splice	c.e12-1	p.G480_splice	CTD-3148I10.9_ENST00000599536.1_Splice_Site_p.T69_splice|ALDH16A1_ENST00000540132.1_Splice_Site_p.G317_splice|ALDH16A1_ENST00000455361.2_Splice_Site_p.G429_splice|ALDH16A1_ENST00000433981.2_Splice_Site_p.G315_splice	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	480							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		CCTCTCACAGGGGCTGTATGA	0.652000													50	8					5.48297e-45	9.05157e-45	0.323286	1	0
BTBD16	118663	broad.mit.edu	37	10	124036380	124036380	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:124036380G>T	ENST00000368994.2	+	3	347	c.96G>T	c.(94-96)ggG>ggT	p.G32G	BTBD16_ENST00000260723.4_Silent_p.G31G			Q32M84	BTBDG_HUMAN	BTB (POZ) domain containing 16	31										breast(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(3)|skin(2)|stomach(1)|urinary_tract(1)	15		all_neural(114;0.107)|Lung NSC(174;0.175)|all_lung(145;0.222)|Breast(234;0.238)				CTTTCTCTGGGGACCTGCTCT	0.527000													33	44					1.08052e-11	1.27578e-11	0.203993	1	0
KIF4A	24137	broad.mit.edu	37	X	69640090	69640090	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:69640090C>T	ENST00000374403.3	+	31	3756	c.3674C>T	c.(3673-3675)tCc>tTc	p.S1225F		NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	1225	Globular.|Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						TCTGGCTGCTCCCCTATCGAA	0.498000													22	21					0	0	0.279207	0	0
MTMR8	55613	broad.mit.edu	37	X	63565051	63565051	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:63565051C>A	ENST00000374852.3	-	7	806	c.739G>T	c.(739-741)Gcc>Tcc	p.A247S	MTMR8_ENST00000453546.1_Missense_Mutation_p.A247S	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	247	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						TTGGCCATGGCATTCAACTGC	0.433000													86	6					2.75442e-36	4.34119e-36	0.323286	1	0
TTN	7273	broad.mit.edu	37	2	179640519	179640519	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179640519A>C	ENST00000589042.1	-	28	6296	c.6072T>G	c.(6070-6072)gaT>gaG	p.D2024E	TTN_ENST00000342175.6_Missense_Mutation_p.D1978E|TTN_ENST00000359218.5_Missense_Mutation_p.D1978E|TTN_ENST00000360870.5_Missense_Mutation_p.D2024E|TTN_ENST00000591111.1_Missense_Mutation_p.D2024E|TTN_ENST00000460472.2_Missense_Mutation_p.D1978E|TTN_ENST00000342992.6_Missense_Mutation_p.D2024E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1786							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATAGGATTCATCCTTCTTTC	0.463000													24	302					0	0	0.279207	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33596337	33596337	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:33596337C>A	ENST00000321505.4	+	9	3609	c.3429C>A	c.(3427-3429)acC>acA	p.T1143T	KIAA1549L_ENST00000389726.3_Silent_p.T1149T|KIAA1549L_ENST00000265654.5_Silent_p.T1149T					KIAA1549-like																		TGTTGGGGACCGCAGCTGCCA	0.532000													113	240					3.41453e-61	6.00159e-61	0.323286	1	0
LRRC6	23639	broad.mit.edu	37	8	133623603	133623603	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:133623603C>A	ENST00000519595.1	-	9	1079	c.981G>T	c.(979-981)atG>atT	p.M327I	LRRC6_ENST00000518642.1_Missense_Mutation_p.M327I|LRRC6_ENST00000250173.1_Missense_Mutation_p.M327I			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	327	CS.					cytoplasm		p.M327I(1)		breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			AAGAGGTATCCATATACCTTC	0.299000													19	25					5.35047e-06	5.73569e-06	0.279207	1	0
GPR27	2850	broad.mit.edu	37	3	71804187	71804187	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:71804187G>T	ENST00000304411.2	+	1	987	c.987G>T	c.(985-987)gcG>gcT	p.A329A		NM_018971.1	NP_061844.1	Q9NS67	GPR27_HUMAN	G protein-coupled receptor 27	329						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(1)|lung(2)|ovary(1)|prostate(1)	5		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.78e-05)|Epithelial(33;5.75e-05)|Lung(16;0.0012)|LUSC - Lung squamous cell carcinoma(21;0.00156)		TGACCTTCGCGCAGGCCGGCA	0.706000													21	14					1.42536e-11	1.67909e-11	0.309145	1	0
TIAM1	7074	broad.mit.edu	37	21	32617977	32617977	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:32617977C>A	ENST00000286827.3	-	7	1883		c.e7-1		TIAM1_ENST00000469412.1_Splice_Site|TIAM1_ENST00000541036.1_Splice_Site	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1						apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						AGCGTGCATCCTGAGGAAACA	0.512000													30	43					6.02846e-25	8.55251e-25	0.183431	1	0
SATB2	23314	broad.mit.edu	37	2	200188559	200188559	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:200188559G>T	ENST00000443023.1	-	8	2797	c.1332C>A	c.(1330-1332)gcC>gcA	p.A444A	SATB2_ENST00000428695.1_Silent_p.A385A|SATB2_ENST00000260926.5_Silent_p.A503A|SATB2_ENST00000417098.1_Silent_p.A503A|SATB2_ENST00000457245.1_Silent_p.A503A			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	503						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TGGCAAACAGGGCTTGAGACA	0.463000													24	174					0.000147802	0.000155167	0.116897	1	0
FLG	2312	broad.mit.edu	37	1	152285069	152285069	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152285069G>T	ENST00000368799.1	-	3	2328	c.2293C>A	c.(2293-2295)Cat>Aat	p.H765N	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	765	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCTGTCCATGGCCTGACACT	0.572000									Ichthyosis				93	243					3.87428e-42	6.31176e-42	0.323286	1	0
C10orf71	118461	broad.mit.edu	37	10	50531556	50531556	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:50531556C>A	ENST00000374144.3	+	3	1254	c.966C>A	c.(964-966)gtC>gtA	p.V322V	C10orf71_ENST00000323868.4_Silent_p.V322V			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	322										endometrium(1)	1						AGCGCACAGTCTCTCCCTGCC	0.582000													47	75					2.9001e-28	4.25467e-28	0.323286	1	0
SHB	6461	broad.mit.edu	37	9	37974623	37974623	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:37974623C>G	ENST00000377707.3	-	3	1615	c.1050G>C	c.(1048-1050)ctG>ctC	p.L350L	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	350	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		CCTTACCTGCCAGGGCTGGGA	0.657000													61	64					0	0	0.323286	0	0
SEMA3E	9723	broad.mit.edu	37	7	83277771	83277771	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:83277771G>T	ENST00000307792.3	-	1	555	c.88C>A	c.(88-90)Cac>Aac	p.H30N		NM_012431.2	NP_036563.1	O15041	SEM3E_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E	30					axon guidance	extracellular space|membrane	receptor activity			breast(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(19)|ovary(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	51		Medulloblastoma(109;0.109)				AACCGGGGGTGGGTAGTATCA	0.433000													31	105					2.42023e-17	3.11273e-17	0.183431	1	0
LDLRAD2	401944	broad.mit.edu	37	1	22138963	22138963	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:22138963C>T	ENST00000344642.2	+	1	206	c.19C>T	c.(19-21)Ctg>Ttg	p.L7L	LDLRAD2_ENST00000543870.1_Silent_p.L7L	NM_001013693.2	NP_001013715.2	Q5SZI1	LRAD2_HUMAN	low density lipoprotein receptor class A domain containing 2	7						integral to membrane	receptor activity			endometrium(2)|large_intestine(1)|lung(3)	6		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.00166)|all_lung(284;0.00172)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;5.2e-26)|COAD - Colon adenocarcinoma(152;1.13e-05)|GBM - Glioblastoma multiforme(114;1.36e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00598)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.197)		TTGTTGTCTTCTGCAGTTGCC	0.597000													11	27					0	0	0.093190	0	0
CXXC11	285093	broad.mit.edu	37	2	242815135	242815135	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:242815135C>A	ENST00000343216.3	+	2	1456	c.1428C>A	c.(1426-1428)ttC>ttA	p.F476L		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	476						integral to membrane											CCATCCCCTTCGCAGTCTTCG	0.627000													10	12					1.61879e-10	1.86788e-10	0.093190	1	0
ADPRH	141	broad.mit.edu	37	3	119306361	119306361	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:119306361T>C	ENST00000478399.1	+	4	2115	c.710T>C	c.(709-711)tTg>tCg	p.L237S	ADPRH_ENST00000465513.1_Missense_Mutation_p.L237S|ADPRH_ENST00000357003.3_Missense_Mutation_p.L237S|ADPRH_ENST00000471850.1_3'UTR|ADPRH_ENST00000478927.1_Missense_Mutation_p.L237S			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	237					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		AGAGGGATTTTGGATGGAGAA	0.438000													6	65					0	0	0.278610	0	0
PDZRN3	23024	broad.mit.edu	37	3	73440205	73440205	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:73440205C>T	ENST00000263666.4	-	6	1431	c.1317G>A	c.(1315-1317)acG>acA	p.T439T	PDZRN3_ENST00000479530.1_Silent_p.T156T|PDZRN3_ENST00000466780.1_Silent_p.T96T|PDZRN3_ENST00000462146.2_Silent_p.T96T|PDZRN3_ENST00000535920.1_Silent_p.T161T|PDZRN3_ENST00000466348.1_5'UTR	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	439	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CTTCATCGTCCGTCCGGTAGC	0.448000													95	230					0	0	0.323286	0	0
HOMEZ	57594	broad.mit.edu	37	14	23746319	23746319	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:23746319C>A	ENST00000357460.5	-	2	282	c.118G>T	c.(118-120)Ggg>Tgg	p.G40W	HOMEZ_ENST00000561013.1_Missense_Mutation_p.G42W|HOMEZ_ENST00000431326.2_Missense_Mutation_p.G42W	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	40						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CAGATGAGCCCCGCTGGTGAA	0.522000													51	66					6.3008e-33	9.6986e-33	0.323286	1	0
SPNS1	83985	broad.mit.edu	37	16	28993708	28993708	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:28993708G>A	ENST00000311008.11	+	8	1374	c.997G>A	c.(997-999)Gga>Aga	p.G333R	SPNS1_ENST00000352260.7_Missense_Mutation_p.G259R|RP11-264B17.3_ENST00000569969.1_RNA|SPNS1_ENST00000334536.8_Missense_Mutation_p.G281R|SPNS1_ENST00000323081.8_Missense_Mutation_p.G260R|SPNS1_ENST00000565975.1_Missense_Mutation_p.G378R	NM_032038.2	NP_114427.1	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 (Drosophila)	333					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)|urinary_tract(1)	21						CTGCCTGACCGGAGTCCTGGG	0.652000													39	53					0	0	0.257332	0	0
THSD7B	80731	broad.mit.edu	37	2	138413070	138413070	+	Splice_Site	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:138413070G>A	ENST00000409968.1	+	22	4123		c.e22-1		THSD7B_ENST00000413152.2_Splice_Site|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000272643.3_Splice_Site					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCCTCTCATAGGGTGGAGACT	0.463000													11	51					0	0	0.080935	0	0
LRRC37B	114659	broad.mit.edu	37	17	30374810	30374810	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:30374810G>T	ENST00000327564.7	+	9	2415	c.2354G>T	c.(2353-2355)gGa>gTa	p.G785V	LRRC37B_ENST00000394713.3_Missense_Mutation_p.G707V|LRRC37B_ENST00000543378.2_Missense_Mutation_p.G676V|LRRC37B_ENST00000341671.7_Missense_Mutation_p.G758V|LRRC37B_ENST00000584368.1_Missense_Mutation_p.G719V			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	758						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				AATCCAGAAGGAGCGTTCATG	0.463000													57	143					1.11718e-16	1.42677e-16	0.323286	1	0
USO1	8615	broad.mit.edu	37	4	76703978	76703978	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:76703978A>G	ENST00000538159.1	+	9	828	c.828A>G	c.(826-828)gcA>gcG	p.A276A	USO1_ENST00000514213.2_Silent_p.A259A			O60763	USO1_HUMAN	USO1 vesicle transport factor	274	Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GCTGGTCTGCACAGAAAGTGA	0.333000													25	4					0	0	0.144211	0	0
OR2W5	441932	broad.mit.edu	37	1	247654702	247654702	+	RNA	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247654702C>G	ENST00000522351.1	+	0	333							A6NFC9	OR2W5_HUMAN							sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(24)|ovary(1)|skin(4)	39	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.222)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CAGAGAAGACCATCACCTACC	0.537000													31	127					0	0	0.235728	0	0
PREX1	57580	broad.mit.edu	37	20	47266656	47266656	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:47266656G>A	ENST00000396220.1	-	24	2928	c.2906C>T	c.(2905-2907)cCc>cTc	p.P969L	PREX1_ENST00000371941.3_Missense_Mutation_p.P969L			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	969					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCAATTGGTGGGGCAGAAGTC	0.602000													111	121					0	0	0.323286	0	0
TSHR	7253	broad.mit.edu	37	14	81606050	81606050	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:81606050C>A	ENST00000541158.2	+	10	1042	c.720C>A	c.(718-720)gcC>gcA	p.A240A	RP11-114N19.3_ENST00000557775.1_RNA|TSHR_ENST00000298171.2_Silent_p.A240A			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	240					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	GTGTCACTGCCCTTCCATCCA	0.517000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						94	102					2.98183e-41	4.82735e-41	0.323286	1	0
C6orf58	352999	broad.mit.edu	37	6	127898552	127898552	+	Nonsense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:127898552T>G	ENST00000329722.7	+	1	234	c.222T>G	c.(220-222)taT>taG	p.Y74*	C6orf58_ENST00000498112.1_Intron	NM_001010905.1	NP_001010905.1	Q6P5S2	CF058_HUMAN	chromosome 6 open reading frame 58	74						extracellular region				kidney(3)|large_intestine(3)|liver(1)|lung(7)|pancreas(1)	15				GBM - Glioblastoma multiforme(226;0.0405)|all cancers(137;0.156)		CAGCCAGGTATTTTGCAAAAT	0.398000													12	149					0	0	0.080935	0	0
MYO1B	4430	broad.mit.edu	37	2	192273773	192273773	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:192273773C>T	ENST00000392318.3	+	26	2882	c.2635C>T	c.(2635-2637)Caa>Taa	p.Q879*	MYO1B_ENST00000304164.4_Nonsense_Mutation_p.Q879*|MYO1B_ENST00000392316.1_Nonsense_Mutation_p.Q850*|MYO1B_ENST00000339514.4_Nonsense_Mutation_p.Q821*|MYO1B_ENST00000439065.2_Nonsense_Mutation_p.Q124*	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	879						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			AACACAGGTGCAAAAATACTT	0.343000													19	92					0	0	0.204396	0	0
KCNMA1	3778	broad.mit.edu	37	10	78880746	78880746	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:78880746T>C	ENST00000286627.5	-	6	1821	c.869A>G	c.(868-870)aAt>aGt	p.N290S	KCNMA1_ENST00000406533.3_Missense_Mutation_p.N290S|KCNMA1_ENST00000404857.1_Missense_Mutation_p.N290S|KCNMA1_ENST00000286628.8_Missense_Mutation_p.N290S|KCNMA1_ENST00000354353.5_Missense_Mutation_p.N290S|KCNMA1_ENST00000372443.1_Missense_Mutation_p.N290S|KCNMA1_ENST00000404771.3_Missense_Mutation_p.N290S|KCNMA1_ENST00000372440.1_Missense_Mutation_p.N290S	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	290					cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TTTAAGAATATTCAGAAACTG	0.333000													13	15					0	0	0.132662	0	0
GPR65	8477	broad.mit.edu	37	14	88478017	88478017	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:88478017G>A	ENST00000267549.3	+	2	1384	c.826G>A	c.(826-828)Gtt>Att	p.V276I	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	276					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TAGAATCACGGTTGCATTAAC	0.373000													34	71					0	0	0.193644	0	0
TENM1	10178	broad.mit.edu	37	X	123517708	123517708	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:123517708G>T	ENST00000422452.2	-	30	7136	c.7073C>A	c.(7072-7074)cCt>cAt	p.P2358H	TENM1_ENST00000371130.3_Missense_Mutation_p.P2351H|STAG2_ENST00000469481.1_Intron	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		CTGAAAGTCAGGGTAAGTGTC	0.433000													52	8					8.99859e-20	1.19711e-19	0.323286	1	0
GRM4	2914	broad.mit.edu	37	6	34003480	34003480	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:34003480G>T	ENST00000374181.3	-	8	2576	c.2407C>A	c.(2407-2409)Ccc>Acc	p.P803T	GRM4_ENST00000544773.1_Missense_Mutation_p.P634T|GRM4_ENST00000538487.1_Missense_Mutation_p.P803T|GRM4_ENST00000535756.1_Missense_Mutation_p.P670T|GRM4_ENST00000455714.2_Missense_Mutation_p.P663T|GRM4_ENST00000374177.3_Missense_Mutation_p.P687T|GRM4_ENST00000545715.1_Missense_Mutation_p.P495T	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	803					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	AAGAAGATGGGGATGAAGGCC	0.622000													20	60					5.49717e-05	5.81446e-05	0.279207	1	0
VWF	7450	broad.mit.edu	37	12	6122739	6122739	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:6122739G>T	ENST00000261405.5	-	32	5782	c.5528C>A	c.(5527-5529)gCa>gAa	p.A1843E		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	1843	VWFA 3; main binding site for collagens type I and III.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	GGAGTCGCCTGCTGGGCCTGC	0.532000													54	53					3.74213e-36	5.8919e-36	0.323286	1	0
ACTN3	89	broad.mit.edu	37	11	66326838	66326838	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66326838G>T	ENST00000504911.1	-	0	220				ACTN3_ENST00000513398.1_RNA|ACTN3_ENST00000502692.1_RNA																							GCACATTGCCGCGCTGGCCCA	0.736000													6	8					5.9392e-07	6.463e-07	0.217242	1	0
IFT81	28981	broad.mit.edu	37	12	110655869	110655869	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:110655869A>C	ENST00000242591.5	+	19	2375	c.1869A>C	c.(1867-1869)aaA>aaC	p.K623N	IFT81_ENST00000552912.1_Missense_Mutation_p.K623N	NM_014055.3	NP_054774.2	Q8WYA0	IFT81_HUMAN	intraflagellar transport 81 homolog (Chlamydomonas)	623					cell differentiation|multicellular organismal development|spermatogenesis	intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)	10						AAAAACAAAAAGTTATACGAG	0.318000													8	7					0	0	0.058154	0	0
EFEMP2	30008	broad.mit.edu	37	11	65638652	65638652	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:65638652G>C	ENST00000307998.6	-	4	573	c.343C>G	c.(343-345)Ccc>Gcc	p.P115A	EFEMP2_ENST00000528176.1_Missense_Mutation_p.P115A	NM_016938.4	NP_058634.4	O95967	FBLN4_HUMAN	EGF containing fibulin-like extracellular matrix protein 2	115					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21				READ - Rectum adenocarcinoma(159;0.169)		TGATCGTCGGGCTCATAGCCT	0.647000													12	33					0	0	0.146539	0	0
IGDCC3	9543	broad.mit.edu	37	15	65623870	65623870	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:65623870G>T	ENST00000327987.4	-	8	1527	c.1276C>A	c.(1276-1278)Cct>Act	p.P426T	IGDCC3_ENST00000559231.1_5'UTR	NM_004884.3	NP_004875.2	Q8IVU1	IGDC3_HUMAN	immunoglobulin superfamily, DCC subclass, member 3	426	Fibronectin type-III 1.									breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(9)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TTGCGGGGAGGCCCGGGGAGC	0.617000													4	14					0.00116845	0.00120784	0.217242	1	0
LMX1B	4010	broad.mit.edu	37	9	129458719	129458719	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:129458719T>G	ENST00000355497.5	+	8	1217	c.1210T>G	c.(1210-1212)Ttc>Gtc	p.F404V	LMX1B_ENST00000561065.1_Missense_Mutation_p.F381V|LMX1B_ENST00000425646.2_Missense_Mutation_p.F370V|LMX1B_ENST00000373474.4_Missense_Mutation_p.F400V|LMX1B_ENST00000526117.1_Missense_Mutation_p.F393V	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	377					dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						GAGTTCCTACTTCGCCTCCTG	0.706000									Nail-Patella Syndrome				9	119					0	0	0.093190	0	0
TMEM18	129787	broad.mit.edu	37	2	675556	675556	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:675556C>A	ENST00000281017.3	-	2	225	c.132G>T	c.(130-132)ttG>ttT	p.L44F	TMEM18_ENST00000405941.3_Missense_Mutation_p.L47F|TMEM18_ENST00000355654.2_Missense_Mutation_p.L31F	NM_152834.2	NP_690047.2	Q96B42	TMM18_HUMAN	transmembrane protein 18	44					cell migration	integral to membrane|nuclear membrane				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)	10	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;5.27e-05)|all_epithelial(98;2.11e-06)|Ovarian(717;0.0253)		all cancers(51;1.95e-21)|Epithelial(75;9.47e-21)|OV - Ovarian serous cystadenocarcinoma(76;8.15e-18)|GBM - Glioblastoma multiforme(21;0.0285)		TTCGGGAGGACAAGCAGGTGA	0.542000													58	110					3.95532e-38	6.30125e-38	0.323286	1	0
LPHN3	23284	broad.mit.edu	37	4	62453099	62453099	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:62453099T>A	ENST00000512091.1	+	4	957	c.210T>A	c.(208-210)ccT>ccA	p.P70P	LPHN3_ENST00000507625.1_Silent_p.P138P|LPHN3_ENST00000506746.1_Silent_p.P138P|LPHN3_ENST00000506700.1_Silent_p.P70P|LPHN3_ENST00000508693.1_Silent_p.P138P|LPHN3_ENST00000509896.1_Silent_p.P138P|LPHN3_ENST00000514591.1_Silent_p.P70P|LPHN3_ENST00000545650.1_Silent_p.P70P|LPHN3_ENST00000504896.1_Silent_p.P70P|LPHN3_ENST00000506720.1_Silent_p.P138P|LPHN3_ENST00000507164.1_Silent_p.P138P|LPHN3_ENST00000511324.1_Silent_p.P138P|LPHN3_ENST00000514996.1_Silent_p.P70P|LPHN3_ENST00000508946.1_Silent_p.P70P|LPHN3_ENST00000514157.1_Silent_p.P70P			Q9HAR2	LPHN3_HUMAN	latrophilin 3	70	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding	p.P70P(3)		breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						ACTCTGACCCTGCTCAGATGG	0.398000													29	8					0	0	0.116897	0	0
TUBB8	347688	broad.mit.edu	37	10	94595	94595	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:94595C>A	ENST00000332708.5	-	2	158	c.128G>T	c.(127-129)gGc>gTc	p.G43V	TUBB8_ENST00000309812.4_Silent_p.G79G|TUBB8_ENST00000413237.3_5'UTR|TUBB8_ENST00000447903.2_Silent_p.G7G			Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 class VIII	357					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			NS(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(12)|ovary(2)|prostate(3)|skin(3)|stomach(1)	32		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		GCCCGAAGGGCCCCGAGCGCA	0.672000													40	97					6.3091e-27	9.13051e-27	0.323286	1	0
NUP133	55746	broad.mit.edu	37	1	229631713	229631713	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:229631713C>A	ENST00000261396.3	-	7	992	c.901G>T	c.(901-903)Gat>Tat	p.D301Y	NUP133_ENST00000366679.1_Missense_Mutation_p.D301Y|NUP133_ENST00000537506.1_Missense_Mutation_p.D285Y	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	301					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TCTGAAGAATCATCTAATTCC	0.363000													54	27					2.22609e-26	3.20511e-26	0.323286	1	0
MYO1G	64005	broad.mit.edu	37	7	45016164	45016164	+	Splice_Site	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:45016164T>C	ENST00000258787.7	-	3	533	c.398_splice	c.e3+1	p.R133_splice		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	133	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						GCCACTCACCTCTCCACCTCA	0.617000													15	12					0	0	0.189662	0	0
OR2G6	391211	broad.mit.edu	37	1	248685107	248685107	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248685107A>G	ENST00000343414.4	+	1	192	c.160A>G	c.(160-162)Aga>Gga	p.R54G		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TCTGGACTCCAGACTCCACAC	0.478000													74	264					0	0	0.323286	0	0
THSD7B	80731	broad.mit.edu	37	2	137814281	137814281	+	Missense_Mutation	SNP	G	G	A	rs147127072	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:137814281G>A	ENST00000409968.1	+	3	609	c.431G>A	c.(430-432)cGc>cAc	p.R144H	THSD7B_ENST00000413152.2_Missense_Mutation_p.R113H|THSD7B_ENST00000543459.1_Missense_Mutation_p.R3H|THSD7B_ENST00000272643.3_Missense_Mutation_p.R144H					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CGGATGGTGCGCTGCATTCAG	0.547000													51	145					0	0	0.323286	0	0
CUTC	51076	broad.mit.edu	37	10	101502997	101502997	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:101502997G>T	ENST00000370476.5	+	4	410	c.281G>T	c.(280-282)cGt>cTt	p.R94L	CUTC_ENST00000493385.1_3'UTR	NM_015960.2	NP_057044.2	Q9NTM9	CUTC_HUMAN	cutC copper transporter	94					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		TATTCAGATCGTGAAATTGAG	0.433000													28	44					1.7881e-09	2.02255e-09	0.134883	1	0
CUBN	8029	broad.mit.edu	37	10	16960652	16960652	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:16960652T>A	ENST00000377833.4	-	45	7034	c.6969A>T	c.(6967-6969)acA>acT	p.T2323T		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2323	CUB 16.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATCCCACATGTGTGGGGCTGT	0.378000													50	126					0	0	0.323286	0	0
WNT11	7481	broad.mit.edu	37	11	75907653	75907653	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:75907653G>C	ENST00000322563.3	-	2	317	c.193C>G	c.(193-195)Ctc>Gtc	p.L65V		NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	65					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						GTGTGCATGAGCTCCAGGTTG	0.647000													22	47					0	0	0.309145	0	0
NFATC4	4776	broad.mit.edu	37	14	24842929	24842929	+	Missense_Mutation	SNP	C	C	G	rs140124494		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:24842929C>G	ENST00000413692.2	+	6	1921	c.1777C>G	c.(1777-1779)Cgg>Ggg	p.R593G	NFATC4_ENST00000250373.4_Missense_Mutation_p.R530G|NFATC4_ENST00000554344.1_Missense_Mutation_p.R460G|NFATC4_ENST00000553879.1_Missense_Mutation_p.R460G|NFATC4_ENST00000556759.1_Missense_Mutation_p.R65G|NFATC4_ENST00000422617.3_Missense_Mutation_p.R518G|NFATC4_ENST00000556279.1_Missense_Mutation_p.R562G|NFATC4_ENST00000539237.2_Missense_Mutation_p.R562G|NFATC4_ENST00000554966.1_Missense_Mutation_p.R543G|NFATC4_ENST00000554591.1_Missense_Mutation_p.R593G|NFATC4_ENST00000556169.1_Missense_Mutation_p.R518G|NFATC4_ENST00000553469.1_Missense_Mutation_p.R562G|NFATC4_ENST00000424781.2_Missense_Mutation_p.R543G|NFATC4_ENST00000554050.1_Missense_Mutation_p.R530G|NFATC4_ENST00000553708.1_Missense_Mutation_p.R530G|NFATC4_ENST00000555167.1_Missense_Mutation_p.R65G|NFATC4_ENST00000557451.1_Missense_Mutation_p.R460G|NFATC4_ENST00000555590.1_Missense_Mutation_p.R543G|NFATC4_ENST00000554661.1_Missense_Mutation_p.R460G|NFATC4_ENST00000555453.1_Missense_Mutation_p.R518G|NFATC4_ENST00000554473.1_Missense_Mutation_p.R65G	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	530	IPT/TIG.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CCTGAAGCTTCGGAATTCAGA	0.567000													34	100					0	0	0.203993	0	0
ZNF41	7592	broad.mit.edu	37	X	47306910	47306910	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:47306910C>A	ENST00000377065.4	-	5	2898	c.2259G>T	c.(2257-2259)caG>caT	p.Q753H	ZNF41_ENST00000397050.2_Missense_Mutation_p.Q763H|ZNF41_ENST00000313116.7_Missense_Mutation_p.Q753H	NM_153380.2	NP_700359.1	P51814	ZNF41_HUMAN	zinc finger protein 41	795						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|upper_aerodigestive_tract(2)	24		all_lung(315;0.000129)				TAAAGGCCTTCTGACATTCTG	0.383000													34	36					8.4185e-14	1.0297e-13	0.163468	1	0
ZBED2	79413	broad.mit.edu	37	3	111312927	111312927	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:111312927G>T	ENST00000317012.4	-	2	1130	c.122C>A	c.(121-123)gCt>gAt	p.A41D	CD96_ENST00000352690.4_Intron|CD96_ENST00000438817.2_Intron|CD96_ENST00000283285.5_Intron	NM_024508.4	NP_078784.2	Q9BTP6	ZBED2_HUMAN	zinc finger, BED-type containing 2	41							DNA binding|metal ion binding			large_intestine(3)|lung(1)|skin(2)	6						AGTGGGCATAGCACTCACAAA	0.532000													20	58					3.73194e-20	5.00989e-20	0.219247	1	0
CYP4V2	285440	broad.mit.edu	37	4	187122322	187122322	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:187122322A>T	ENST00000378802.4	+	7	1117	c.813A>T	c.(811-813)gaA>gaT	p.E271D		NM_207352.3	NP_997235.3	Q6ZWL3	CP4V2_HUMAN	cytochrome P450, family 4, subfamily V, polypeptide 2	271					response to stimulus|visual perception	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(1)|stomach(2)	20		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.33e-10)|BRCA - Breast invasive adenocarcinoma(30;3.84e-05)|GBM - Glioblastoma multiforme(59;0.000132)|STAD - Stomach adenocarcinoma(60;0.000293)|LUSC - Lung squamous cell carcinoma(40;0.00242)|READ - Rectum adenocarcinoma(43;0.17)		TCATCGCTGAACGGGCCAATG	0.423000													6	85					0	0	0.248553	0	0
ICAM2	3384	broad.mit.edu	37	17	62081157	62081157	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:62081157G>T	ENST00000412356.1	-	5	850	c.496C>A	c.(496-498)Cct>Act	p.P166T	ICAM2_ENST00000579687.1_Missense_Mutation_p.P166T|ICAM2_ENST00000578892.1_Missense_Mutation_p.P142T|ICAM2_ENST00000578379.1_Missense_Mutation_p.P65T|ICAM2_ENST00000449662.2_Missense_Mutation_p.P166T|ICAM2_ENST00000418105.1_Missense_Mutation_p.P166T|C17orf72_ENST00000412177.1_3'UTR|ICAM2_ENST00000581417.1_5'UTR|ICAM2_ENST00000579788.1_Missense_Mutation_p.P166T	NM_001099786.1	NP_001093256.1	P13598	ICAM2_HUMAN	intercellular adhesion molecule 2	166	Ig-like C2-type 2.				cell-cell adhesion|regulation of immune response	integral to plasma membrane	integrin binding			large_intestine(1)|lung(2)|ovary(1)|skin(2)	6						TGCGGAGCAGGGGCTGCCTTC	0.617000													7	23					3.07112e-06	3.29908e-06	0.080935	1	0
HTR3E	285242	broad.mit.edu	37	3	183822695	183822695	+	Silent	SNP	C	C	T	rs145422207		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:183822695C>T	ENST00000415389.2	+	5	976	c.510C>T	c.(508-510)ccC>ccT	p.P170P	HTR3E_ENST00000436361.2_Silent_p.P170P|HTR3E_ENST00000425359.2_Silent_p.P155P|HTR3E_ENST00000440596.2_Silent_p.P196P|HTR3E-AS1_ENST00000431427.1_RNA|HTR3E_ENST00000335304.2_Silent_p.P185P	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	170						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TCTACTTCCCCTTCGACCAGC	0.473000													53	127					0	0	0.323286	0	0
CTNNA2	1496	broad.mit.edu	37	2	80085187	80085187	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:80085187C>A	ENST00000466387.1	+	8	1071	c.347C>A	c.(346-348)tCg>tAg	p.S116*	CTNNA2_ENST00000361291.4_Nonsense_Mutation_p.S150*|CTNNA2_ENST00000541047.1_Nonsense_Mutation_p.S116*|CTNNA2_ENST00000540488.1_Nonsense_Mutation_p.S116*|CTNNA2_ENST00000402739.4_Nonsense_Mutation_p.S116*|CTNNA2_ENST00000496558.1_Nonsense_Mutation_p.S116*			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	116					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						GACCCTTGCTCGTCGGTAAAG	0.587000													64	85					2.60599e-31	3.9408e-31	0.323286	1	0
SP1	6667	broad.mit.edu	37	12	53800476	53800476	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:53800476G>T	ENST00000426431.2	+	4	1822	c.1762G>T	c.(1762-1764)Gcc>Tcc	p.A588S	SP1_ENST00000327443.4_Missense_Mutation_p.A595S	NM_003109.1	NP_003100.1	P08047	SP1_HUMAN	Sp1 transcription factor	595	Transactivation domain C (highly charged).				positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	double-stranded DNA binding|histone deacetylase binding|HMG box domain binding|protein C-terminus binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.00527)		CCAACCCCAAGCCGGTCGGAG	0.537000													45	21					1.21353e-23	1.70291e-23	0.323286	1	0
SPACA1	81833	broad.mit.edu	37	6	88775996	88775996	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:88775996C>A	ENST00000237201.1	+	7	945	c.828C>A	c.(826-828)gaC>gaA	p.D276E	SPACA1_ENST00000462690.1_3'UTR	NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	276						integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		CTTCTCTTGACCAATTACCAA	0.408000													21	74					2.32416e-17	2.9929e-17	0.249174	1	0
TRIP12	9320	broad.mit.edu	37	2	230693988	230693988	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:230693988C>T	ENST00000283943.5	-	7	1405	c.1227G>A	c.(1225-1227)agG>agA	p.R409R	TRIP12_ENST00000389044.4_Silent_p.R457R|TRIP12_ENST00000543084.1_Intron|TRIP12_ENST00000389045.3_Silent_p.R112R	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	409					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		GGGGAAGACCCCTTGCCTCTA	0.403000													10	83					0	0	0.105934	0	0
NFATC3	4775	broad.mit.edu	37	16	68156649	68156649	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:68156649C>T	ENST00000349223.5	+	2	1087	c.863C>T	c.(862-864)tCa>tTa	p.S288L	NFATC3_ENST00000329524.4_Missense_Mutation_p.S288L|NFATC3_ENST00000575270.1_Missense_Mutation_p.S288L|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.S288L	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	288	3 X SP repeats.				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		GGGTCCCTTTCACCCCATCAC	0.582000													31	83					0	0	0.193644	0	0
SPAG6	9576	broad.mit.edu	37	10	22653940	22653940	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:22653940G>T	ENST00000376603.2	+	3	650	c.508G>T	c.(508-510)Gaa>Taa	p.E170*	SPAG6_ENST00000538630.1_Nonsense_Mutation_p.E69*|SPAG6_ENST00000376624.3_Nonsense_Mutation_p.E94*|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000376601.1_Nonsense_Mutation_p.E94*|SPAG6_ENST00000313311.6_Nonsense_Mutation_p.E94*			O75602	SPAG6_HUMAN	sperm associated antigen 6	94					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						TTCATTGGCAGAACAGAATGT	0.358000													16	28					1.5739e-10	1.81947e-10	0.146539	1	0
CAMK4	814	broad.mit.edu	37	5	110819971	110819971	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:110819971C>A	ENST00000282356.4	+	11	1627	c.1229C>A	c.(1228-1230)gCt>gAt	p.A410D	CAMK4_ENST00000512453.1_Missense_Mutation_p.A410D|CAMK4_ENST00000512890.1_3'UTR	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	410					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		GATATAAATGCTGAAGAGGCC	0.527000													30	50					9.78306e-22	1.33885e-21	0.144211	1	0
BTBD11	121551	broad.mit.edu	37	12	108011113	108011113	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:108011113G>A	ENST00000280758.5	+	9	2659	c.2131G>A	c.(2131-2133)Ggt>Agt	p.G711S	BTBD11_ENST00000420571.2_Intron|BTBD11_ENST00000490090.2_Missense_Mutation_p.G711S|RP11-128P10.1_ENST00000548473.1_RNA|BTBD11_ENST00000357167.4_Missense_Mutation_p.G248S	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	711						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						GTTGGAGCGTGGTGCCGATCC	0.478000													85	8					0	0	0.323286	0	0
HYDIN	54768	broad.mit.edu	37	16	70942679	70942679	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:70942679T>A	ENST00000393567.2	-	48	8240	c.8090A>T	c.(8089-8091)gAc>gTc	p.D2697V		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2697										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GTGACGCTTGTCTTTCTGAAT	0.468000													114	59					0	0	0.323286	0	0
FLG	2312	broad.mit.edu	37	1	152284255	152284255	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152284255C>T	ENST00000368799.1	-	3	3142	c.3107G>A	c.(3106-3108)cGc>cAc	p.R1036H	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1036	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGCTGGTGGCGGGATCCGTG	0.562000									Ichthyosis				7	407					0	0	0.307466	0	0
ABCA1	19	broad.mit.edu	37	9	107594092	107594092	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:107594092T>A	ENST00000374736.3	-	13	1920	c.1526A>T	c.(1525-1527)aAg>aTg	p.K509M		NM_005502.3	NP_005493.2	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 1	509					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(31)|liver(1)|lung(40)|ovary(5)|pancreas(2)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	115				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GGGTTCTAGCTTGTTCAGGTT	0.483000													67	115					0	0	0.323286	0	0
FCRL3	115352	broad.mit.edu	37	1	157665371	157665371	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157665371A>C	ENST00000368184.3	-	8	1450	c.1159T>G	c.(1159-1161)Ttc>Gtc	p.F387V	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Missense_Mutation_p.F387V|RP11-367J7.3_ENST00000453692.1_RNA	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	387	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GGAGCCCTGAAGGTGAGGACA	0.562000													61	128					0	0	0.323286	0	0
DDX60L	91351	broad.mit.edu	37	4	169343778	169343778	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:169343778C>A	ENST00000511577.1	-	16	2388	c.2141G>T	c.(2140-2142)gGa>gTa	p.G714V	DDX60L_ENST00000505890.1_Missense_Mutation_p.G714V|DDX60L_ENST00000260184.7_Missense_Mutation_p.G714V			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	714							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CCGAGCTGGTCCAATGTCAAT	0.338000													5	26					1.23904e-05	1.31776e-05	0.184627	1	0
PSG9	5678	broad.mit.edu	37	19	43762590	43762590	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:43762590C>T	ENST00000244293.7	-	4	794	c.728G>A	c.(727-729)aGa>aAa	p.R243K	PSG9_ENST00000291752.5_Missense_Mutation_p.R150K|PSG9_ENST00000270077.3_Missense_Mutation_p.R336K|PSG9_ENST00000418820.2_Missense_Mutation_p.R243K|PSG9_ENST00000443718.3_Missense_Mutation_p.R243K|PSG9_ENST00000593948.1_Missense_Mutation_p.R243K|PSG9_ENST00000596730.1_Missense_Mutation_p.R150K			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	241	Ig-like C2-type 2.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				AGGGTAAATTCTGGGGAGGTC	0.473000													242	34					0	0	0.323286	0	0
DARC	2532	broad.mit.edu	37	1	159176115	159176115	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:159176115C>G	ENST00000537147.1	+	3	1729	c.886C>G	c.(886-888)Cac>Gac	p.H296D	DARC_ENST00000368121.2_Missense_Mutation_p.H298D|DARC_ENST00000368122.2_Missense_Mutation_p.H296D			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	296					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity	p.H298N(1)		large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					GGCAATTTTGCACTGTGTGGC	0.597000													131	293					0	0	0.323286	0	0
NRP2	8828	broad.mit.edu	37	2	206659528	206659528	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:206659528G>T	ENST00000360409.3	+	17	3333	c.2542G>T	c.(2542-2544)Ggc>Tgc	p.G848C	NRP2_ENST00000540178.1_Missense_Mutation_p.G843C|NRP2_ENST00000412873.2_Missense_Mutation_p.G826C|NRP2_ENST00000540841.1_Missense_Mutation_p.G826C|NRP2_ENST00000357785.5_Missense_Mutation_p.G843C	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	848					angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						CTCAGGGTCTGGCGCCCCCTC	0.547000													48	160					2.84144e-21	3.86301e-21	0.323286	1	0
CCDC80	151887	broad.mit.edu	37	3	112328923	112328923	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:112328923C>A	ENST00000206423.3	-	6	3280	c.2327G>T	c.(2326-2328)cGg>cTg	p.R776L	CCDC80_ENST00000439685.2_Missense_Mutation_p.R776L	NM_199511.1|NM_199512.1	NP_955805.1|NP_955806.1	Q76M96	CCD80_HUMAN	coiled-coil domain containing 80	776										breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(21)|ovary(3)|pancreas(2)|prostate(4)	51						CCTCCTCCACCGGAACCTGGA	0.463000													61	48					9.53695e-23	1.32389e-22	0.323286	1	0
DNAJC1	64215	broad.mit.edu	37	10	22209839	22209839	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:22209839T>C	ENST00000376980.3	-	4	715	c.425A>G	c.(424-426)tAc>tGc	p.Y142C	DNAJC1_ENST00000376946.1_3'UTR	NM_022365.3	NP_071760.2	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	142					negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(13)|skin(2)|upper_aerodigestive_tract(2)	21		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				CCGCCTGTAGTAGAATACAGG	0.398000													22	78					0	0	0.225048	0	0
GJA8	2703	broad.mit.edu	37	1	147380481	147380481	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:147380481C>A	ENST00000240986.4	+	2	452	c.399C>A	c.(397-399)agC>agA	p.S133R	GJA8_ENST00000369235.1_Missense_Mutation_p.S133R	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	133					cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					AGAAGAGCAGCGGCAGCAAAG	0.622000													94	33					4.21061e-56	7.27692e-56	0.323286	1	0
ABCB6	10058	broad.mit.edu	37	2	220077171	220077171	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220077171G>C	ENST00000265316.3	-	14	2222	c.1906C>G	c.(1906-1908)Ctg>Gtg	p.L636V	ABCB6_ENST00000439002.2_Missense_Mutation_p.L590V	NM_005689.2	NP_005680.1	Q9NP58	ABCB6_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 6	636	ABC transporter.				cadmium ion transmembrane transport|cellular iron ion homeostasis|detoxification of cadmium ion|porphyrin biosynthetic process	ATP-binding cassette (ABC) transporter complex|Golgi apparatus|integral to mitochondrial outer membrane|plasma membrane|vacuolar membrane	ATP binding|efflux transmembrane transporter activity|heme binding|heme-transporting ATPase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	34		Renal(207;0.0474)		Epithelial(149;1.22e-06)|all cancers(144;0.000201)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AAGCGAAACAGCAGGCGCAAA	0.517000													18	66					0	0	0.189662	0	0
SACS	26278	broad.mit.edu	37	13	23908500	23908500	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:23908500T>C	ENST00000382298.3	-	10	10103	c.9515A>G	c.(9514-9516)aAg>aGg	p.K3172R	SACS_ENST00000402364.1_Missense_Mutation_p.K2422R|SACS_ENST00000382292.3_Missense_Mutation_p.K3172R	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	3172					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTTAGAAACTTGGGTCGTTT	0.323000													9	18					0	0	0.058154	0	0
COL6A3	1293	broad.mit.edu	37	2	238287348	238287348	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:238287348G>C	ENST00000295550.4	-	6	2880	c.2428C>G	c.(2428-2430)Cag>Gag	p.Q810E	COL6A3_ENST00000346358.4_Intron|COL6A3_ENST00000392004.3_Missense_Mutation_p.Q604E|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000409809.1_Missense_Mutation_p.Q604E|COL6A3_ENST00000392003.2_Missense_Mutation_p.Q403E|COL6A3_ENST00000347401.3_Missense_Mutation_p.Q609E|COL6A3_ENST00000353578.4_Missense_Mutation_p.Q604E	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	810	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ATCAGCTGCTGAGGCAAAGCT	0.542000													56	211					0	0	0.323286	0	0
CAPNS2	84290	broad.mit.edu	37	16	55601073	55601073	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:55601073G>A	ENST00000457326.2	+	1	490	c.405G>A	c.(403-405)acG>acA	p.T135T	LPCAT2_ENST00000565056.1_Intron|LPCAT2_ENST00000262134.5_Intron	NM_032330.1	NP_115706.1	Q96L46	CPNS2_HUMAN	calpain, small subunit 2	135	EF-hand 1.					cytoplasm|plasma membrane	calcium ion binding			central_nervous_system(1)|large_intestine(1)|lung(3)|prostate(2)	7						ACAGTGACACGACTGGTAAGC	0.428000													33	366					0	0	0.183431	0	0
FLG2	388698	broad.mit.edu	37	1	152324583	152324583	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152324583T>G	ENST00000388718.5	-	3	5751	c.5679A>C	c.(5677-5679)tcA>tcC	p.S1893S	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1893							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AATGTGTATGTGAGCCCCCTG	0.512000													128	285					0	0	0.323286	0	0
GPR18	2841	broad.mit.edu	37	13	99907330	99907330	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:99907330G>A	ENST00000340807.3	-	3	1353	c.797C>T	c.(796-798)cCc>cTc	p.P266L	GPR18_ENST00000397473.2_Missense_Mutation_p.P266L|UBAC2_ENST00000376440.2_Intron|UBAC2_ENST00000403766.3_Intron|GPR18_ENST00000397470.2_Missense_Mutation_p.P266L			Q14330	GPR18_HUMAN	G protein-coupled receptor 18	266						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(2)|large_intestine(2)|lung(6)	10	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Glycine(DB00145)	GGCTCCCCAGGGATTGTAACT	0.493000													55	279					0	0	0.323286	0	0
PDLIM3	27295	broad.mit.edu	37	4	186423597	186423597	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:186423597C>G	ENST00000284770.5	-	8	1019	c.946G>C	c.(946-948)Gag>Cag	p.E316Q	PDLIM3_ENST00000284767.5_3'UTR|PDLIM3_ENST00000284771.6_Missense_Mutation_p.E268Q	NM_014476.5	NP_055291.2	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain 3	316	LIM zinc-binding.					sarcomere	zinc ion binding			breast(2)|endometrium(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		ACGAAGCACTCAGGGTGCCGG	0.522000													103	92					0	0	0.323286	0	0
TMEM135	65084	broad.mit.edu	37	11	86868446	86868446	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:86868446G>T	ENST00000305494.5	+	5	499	c.460G>T	c.(460-462)Gaa>Taa	p.E154*	TMEM135_ENST00000340353.7_Intron|TMEM135_ENST00000532959.1_Nonsense_Mutation_p.E25*|TMEM135_ENST00000535167.1_Nonsense_Mutation_p.E15*|TMEM135_ENST00000355734.4_Intron	NM_022918.3	NP_075069.3	Q86UB9	TM135_HUMAN	transmembrane protein 135	154						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				AAGAAATGGAGAAGTAAGATG	0.274000													70	184					1.00246e-47	1.67185e-47	0.323286	1	0
DARC	2532	broad.mit.edu	37	1	159175960	159175960	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:159175960A>T	ENST00000537147.1	+	3	1574	c.731A>T	c.(730-732)aAt>aTt	p.N244I	DARC_ENST00000368121.2_Missense_Mutation_p.N246I|DARC_ENST00000368122.2_Missense_Mutation_p.N244I			Q16570	DUFFY_HUMAN	Duffy blood group, atypical chemokine receptor	244					defense response	integral to membrane|plasma membrane	C-C chemokine binding|chemokine receptor activity			large_intestine(2)|lung(1)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	8	all_hematologic(112;0.0429)					CCCTGGATGAATATCCTGTGG	0.522000													49	130					0	0	0.323286	0	0
POLA2	23649	broad.mit.edu	37	11	65048481	65048481	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:65048481G>T	ENST00000265465.3	+	8	1294	c.763G>T	c.(763-765)Ggc>Tgc	p.G255C	POLA2_ENST00000541089.1_Missense_Mutation_p.G47C	NM_002689.2	NP_002680.2	Q14181	DPOA2_HUMAN	polymerase (DNA directed), alpha 2, accessory subunit	255					DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	nucleoplasm	DNA binding			endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	11					Dacarbazine(DB00851)	CACTCTGCTGGGCCAGATTGG	0.493000													19	66					4.65686e-17	5.97692e-17	0.193644	1	0
MDGA2	161357	broad.mit.edu	37	14	47600949	47600949	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:47600949T>C	ENST00000439988.2	-	5	685	c.686A>G	c.(685-687)aAg>aGg	p.K229R	MDGA2_ENST00000357362.3_5'UTR|MDGA2_ENST00000399232.2_Missense_Mutation_p.K298R|MDGA2_ENST00000426342.1_5'UTR			Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	229	Ig-like 2.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						CGACACCATCTTATCAGGAAT	0.328000													6	100					0	0	0.307466	0	0
SNHG14	104472715	broad.mit.edu	37	15	25446528	25446528	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:25446528C>A	ENST00000424208.1	+	0	1988				SNHG14_ENST00000424333.1_RNA|SNORD115-17_ENST00000364612.1_RNA	NR_003305.1																						AAAAATCATTCTCAAAAGGAT	0.493000													34	35					2.20474e-14	2.73013e-14	0.193644	1	0
STARD6	147323	broad.mit.edu	37	18	51858163	51858163	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:51858163T>A	ENST00000581310.1	-	7	707	c.334A>T	c.(334-336)Atc>Ttc	p.I112F	STARD6_ENST00000307844.3_Missense_Mutation_p.I112F|STARD6_ENST00000580990.2_Missense_Mutation_p.Y19F			P59095	STAR6_HUMAN	StAR-related lipid transfer (START) domain containing 6	112	START.				lipid transport		lipid binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)	8				Colorectal(16;0.021)|READ - Rectum adenocarcinoma(59;0.188)		ACTAAGTCGATAAAGTCTCGA	0.388000													164	14					0	0	0.323286	0	0
TMPRSS12	283471	broad.mit.edu	37	12	51252735	51252735	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:51252735A>T	ENST00000551456.1	+	3	596	c.551A>T	c.(550-552)aAt>aTt	p.N184I	TMPRSS12_ENST00000398458.3_Missense_Mutation_p.N184I			Q86WS5	TMPSC_HUMAN	transmembrane (C-terminal) protease, serine 12	184	Peptidase S1.				proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	18						GTGAGGTATAATGACTATATT	0.313000													11	18					0	0	0.069234	0	0
MUC6	4588	broad.mit.edu	37	11	1017147	1017147	+	Missense_Mutation	SNP	G	G	T	rs71472140		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:1017147G>T	ENST00000421673.2	-	31	5704	c.5654C>A	c.(5653-5655)gCc>gAc	p.A1885D		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1885	Approximate repeats.|Thr-rich.			PTTIKA -> LTTLMN (in Ref. 5; AAA35866).	maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGACCCTGTGGCCTTGATCGT	0.567000													44	159					8.00217e-19	1.0519e-18	0.323286	1	0
CEACAM20	125931	broad.mit.edu	37	19	45024771	45024771	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:45024771G>T	ENST00000454753.1	-	0	1045							Q6UY09	CEA20_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 20							integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|prostate(1)	15		Prostate(69;0.0352)				CACGACTTGAGGCATGGTCAG	0.517000													247	33					4.62389e-141	8.55447e-141	0.323286	1	0
DCAF8L2	347442	broad.mit.edu	37	X	27766653	27766653	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:27766653C>A	ENST00000451261.2	+	5	2040	c.1641C>A	c.(1639-1641)gcC>gcA	p.A547A		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						CTAAAGCTGCCACTGAGCTTA	0.478000													27	25					6.84511e-11	7.95471e-11	0.183431	1	0
SLC45A4	57210	broad.mit.edu	37	8	142221580	142221580	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:142221580C>G	ENST00000024061.3	-	8	2665	c.2358G>C	c.(2356-2358)tgG>tgC	p.W786C	SLC45A4_ENST00000433583.2_3'UTR|SLC45A4_ENST00000519067.1_3'UTR|SLC45A4_ENST00000517878.1_3'UTR	NM_001080431.1	NP_001073900.1	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	0					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CAGCCTCCTCCCAGCTTTGGT	0.627000													20	16					0	0	0.249174	0	0
ATP13A1	57130	broad.mit.edu	37	19	19770519	19770519	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19770519G>C	ENST00000357324.6	-	3	594	c.568C>G	c.(568-570)Ctc>Gtc	p.L190V	ATP13A1_ENST00000291503.5_Missense_Mutation_p.L72V	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	190					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GCCACGGGGAGAAACTGCTTC	0.517000													8	74					0	0	0.307466	0	0
NUTM1	256646	broad.mit.edu	37	15	34640339	34640339	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:34640339G>A	ENST00000537011.1	+	3	652	c.270G>A	c.(268-270)atG>atA	p.M90I	NUTM1_ENST00000438749.3_Missense_Mutation_p.M80I|NUTM1_ENST00000333756.4_Missense_Mutation_p.M62I					NUT midline carcinoma, family member 1																		ACCCTCTGATGCTCTCTGCTT	0.582000													96	117					0	0	0.323286	0	0
C14orf166	51637	broad.mit.edu	37	14	52458077	52458077	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:52458077A>G	ENST00000261700.3	+	2	269	c.104A>G	c.(103-105)cAg>cGg	p.Q35R	C14orf166_ENST00000556760.1_Missense_Mutation_p.Q35R	NM_016039.2	NP_057123.1	Q9Y224	CN166_HUMAN	chromosome 14 open reading frame 166	35						microtubule organizing center|nucleus|perinuclear region of cytoplasm|tRNA-splicing ligase complex	identical protein binding			endometrium(1)|large_intestine(3)|lung(2)	6	Breast(41;0.0639)|all_epithelial(31;0.101)					CTTGAAGACCAGAAAATCAGG	0.358000													7	150					0	0	0.278610	0	0
FBN2	2201	broad.mit.edu	37	5	127610317	127610317	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:127610317C>A	ENST00000508053.1	-	66	8627	c.7653G>T	c.(7651-7653)ctG>ctT	p.L2551L	FBN2_ENST00000262464.4_Silent_p.L2551L			P35556	FBN2_HUMAN	fibrillin 2	2551	EGF-like 43; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TAAACCCCCCCAGGGTGTTGA	0.418000													65	82					2.36135e-34	3.67309e-34	0.323286	1	0
RC3H2	54542	broad.mit.edu	37	9	125659558	125659558	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:125659558C>A	ENST00000373670.1	-	1	831	c.231_splice	c.e1+1	p.Q77_splice	RC3H2_ENST00000373665.2_Splice_Site_p.Q77_splice|RC3H2_ENST00000471874.2_Splice_Site_p.Q77_splice|RC3H2_ENST00000478216.1_Intron|RC3H2_ENST00000335387.5_Splice_Site_p.Q77_splice|RC3H2_ENST00000423239.2_Splice_Site_p.Q77_splice|RC3H2_ENST00000357244.2_Splice_Site_p.Q77_splice			Q9HBD1	RC3H2_HUMAN	ring finger and CCCH-type domains 2	77						cell surface|endomembrane system|membrane|membrane fraction|perinuclear region of cytoplasm	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|large_intestine(4)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GAATGCTTACCTGGGCTCCAA	0.423000													21	17					7.45023e-12	8.82346e-12	0.219247	1	0
TMPRSS11E	28983	broad.mit.edu	37	4	69362485	69362485	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:69362485C>A	ENST00000305363.4	+	10	1299	c.1235C>A	c.(1234-1236)gCc>gAc	p.A412D		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	412	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						AGAGTTACGGCCTTGCGGGAC	0.423000													133	110					2.49262e-74	4.4545e-74	0.323286	1	0
LRRC16B	90668	broad.mit.edu	37	14	24528928	24528928	+	Silent	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:24528928A>C	ENST00000342740.5	+	22	2009	c.1855A>C	c.(1855-1857)Agg>Cgg	p.R619R	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	619										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GGACATCGCAAGGGCCCTGGA	0.597000													11	29					0	0	0.105934	0	0
ANKS4B	257629	broad.mit.edu	37	16	21261872	21261872	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:21261872C>A	ENST00000311620.5	+	2	1058	c.985C>A	c.(985-987)Ctg>Atg	p.L329M		NM_145865.2	NP_665872.2	Q8N8V4	ANS4B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 4B	329										NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|lung(11)|ovary(2)	20				GBM - Glioblastoma multiforme(48;0.0565)		CAAAGATGATCTGCCGTGGGA	0.522000													67	11					5.44642e-36	8.56656e-36	0.323286	1	0
FAT3	120114	broad.mit.edu	37	11	92616245	92616245	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:92616245C>A	ENST00000298047.6	+	23	12640	c.12623C>A	c.(12622-12624)cCg>cAg	p.P4208Q	FAT3_ENST00000525166.1_Missense_Mutation_p.P4058Q|FAT3_ENST00000409404.2_Missense_Mutation_p.P4208Q|FAT3_ENST00000533797.1_Missense_Mutation_p.P543Q			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4208					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AATGGCATCCCGTTCCGGAAC	0.652000										TCGA Ovarian(4;0.039)			22	46					1.85244e-09	2.0938e-09	0.279207	1	0
SLC44A5	204962	broad.mit.edu	37	1	75684994	75684994	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:75684994A>C	ENST00000370855.5	-	16	1327	c.1214T>G	c.(1213-1215)gTc>gGc	p.V405G	SLC44A5_ENST00000370859.3_Missense_Mutation_p.V405G|SLC44A5_ENST00000535611.1_Missense_Mutation_p.V275G	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	405						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						TGGAGCTATGACTTTGTATAC	0.378000													17	48					0	0	0.204396	0	0
CATSPER2P1	440278	broad.mit.edu	37	15	44028264	44028264	+	RNA	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:44028264C>G	ENST00000381680.2	-	0	1520					NR_002318.2																						catgagccaccgcacccggcc	0.527000													27	15					0	0	0.324025	0	0
DMD	1756	broad.mit.edu	37	X	32466604	32466604	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:32466604G>T	ENST00000357033.4	-	27	3961	c.3755C>A	c.(3754-3756)aCt>aAt	p.T1252N	DMD_ENST00000378677.2_Missense_Mutation_p.T1248N	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1252					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ATTCAGCCTAGTGCAGAGCCA	0.423000													99	92					1.58909e-51	2.69814e-51	0.323286	1	0
CEP350	9857	broad.mit.edu	37	1	180006108	180006108	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:180006108G>T	ENST00000367607.3	+	17	4412	c.3994G>T	c.(3994-3996)Gaa>Taa	p.E1332*		NM_014810.4	NP_055625.4	Q5VT06	CE350_HUMAN	centrosomal protein 350kDa	1332						centrosome|nucleus|spindle				central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	66						TATGGCAGCAGAACTCAGTTA	0.468000													3	7					0.000602214	0.000625229	0.184627	1	0
MMP19	4327	broad.mit.edu	37	12	56233401	56233401	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:56233401G>T	ENST00000322569.4	-	5	736	c.645C>A	c.(643-645)ggC>ggA	p.G215G	MMP19_ENST00000409200.3_Intron|MMP19_ENST00000548629.1_Silent_p.G192G	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	215					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						CCAGAGCATGGCCCACTTCAT	0.612000													20	48					6.36457e-07	6.92346e-07	0.294199	1	0
KIAA1430	57587	broad.mit.edu	37	4	186083983	186083983	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:186083983T>C	ENST00000458385.2	-	5	1687	c.1568A>G	c.(1567-1569)aAa>aGa	p.K523R		NM_020827.1	NP_065878.1	Q9P2B7	K1430_HUMAN	KIAA1430	523										endometrium(3)|kidney(2)|large_intestine(5)|upper_aerodigestive_tract(1)	11		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		ATTAGGGGGTTTAGGTCTTCT	0.458000													4	26					0	0	0.150653	0	0
GPR98	84059	broad.mit.edu	37	5	89953810	89953810	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:89953810A>C	ENST00000405460.2	+	21	4563	c.4467A>C	c.(4465-4467)aaA>aaC	p.K1489N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1489					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		ATGAGCGGAAACTGACGCTTG	0.433000													65	113					0	0	0.323286	0	0
HINFP	25988	broad.mit.edu	37	11	119003699	119003699	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:119003699G>A	ENST00000350777.2	+	8	1064	c.1001G>A	c.(1000-1002)cGc>cAc	p.R334H	HINFP_ENST00000527410.1_Missense_Mutation_p.R334H	NM_001243259.1|NM_015517.4|NM_198971.2	NP_001230188.1|NP_056332.2|NP_945322.1	Q9BQA5	HINFP_HUMAN	histone H4 transcription factor	334					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						TCCCATTACCGCAAAGTACAT	0.547000													6	175					0	0	0.248553	0	0
KIAA1804	84451	broad.mit.edu	37	1	233490644	233490644	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:233490644G>T	ENST00000366624.3	+	4	1459	c.1198G>T	c.(1198-1200)Gct>Tct	p.A400S	MLK4_ENST00000366623.3_Missense_Mutation_p.A400S	NM_032435.2	NP_115811.2																					ACAGTTGACTGCTATTGAAGG	0.378000													78	354					1.5608e-48	2.61428e-48	0.323286	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125660604	125660604	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:125660604C>A	ENST00000431078.1	+	22	3943	c.3579C>A	c.(3577-3579)acC>acA	p.T1193T		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	1193	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TCCATGGGACCTTGACGGAAT	0.547000													17	75					4.35082e-09	4.87499e-09	0.219247	1	0
PDPK1	5170	broad.mit.edu	37	16	2607912	2607912	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:2607912G>A	ENST00000342085.4	+	2	382	c.233G>A	c.(232-234)cGg>cAg	p.R78Q	PDPK1_ENST00000441549.3_Missense_Mutation_p.R78Q|PDPK1_ENST00000389224.3_Missense_Mutation_p.R51Q|PDPK1_ENST00000354836.5_Missense_Mutation_p.R78Q|PDPK1_ENST00000268673.7_Missense_Mutation_p.R78Q	NM_002613.4	NP_002604.1	O15530	PDPK1_HUMAN	3-phosphoinositide dependent protein kinase-1	78					actin cytoskeleton organization|activation of protein kinase B activity|insulin receptor signaling pathway|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|peptidyl-threonine phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|synaptic transmission|T cell costimulation|T cell receptor signaling pathway	cytosol|nucleoplasm|plasma membrane	3-phosphoinositide-dependent protein kinase activity|ATP binding			central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	7		Ovarian(90;0.17)			Celecoxib(DB00482)	CGGAAGAAGCGGCCTGAGGAC	0.627000													4	28					0	0	0.217242	0	0
EML3	256364	broad.mit.edu	37	11	62375672	62375672	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:62375672C>A	ENST00000394773.2	-	10	1514		c.e10+1		EML3_ENST00000531557.1_Splice_Site|EML3_ENST00000278845.4_Splice_Site|EML3_ENST00000494176.2_Splice_Site|EML3_ENST00000529309.1_Splice_Site	NM_153265.2	NP_694997.2	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like 3							cytoplasm|microtubule	protein binding			biliary_tract(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						GGACTCCTCACCTTGATCTCA	0.562000													70	121					4.47563e-24	6.30621e-24	0.323286	1	0
RYR1	6261	broad.mit.edu	37	19	38960104	38960104	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:38960104A>C	ENST00000355481.4	+	27	3847	c.3716A>C	c.(3715-3717)aAa>aCa	p.K1239T	RYR1_ENST00000359596.3_Missense_Mutation_p.K1239T|RYR1_ENST00000360985.3_Missense_Mutation_p.K1239T	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1239	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGGTTCAGCAAAGGCCTGCCC	0.567000													75	179					0	0	0.323286	0	0
TAS2R16	50833	broad.mit.edu	37	7	122635622	122635622	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:122635622C>A	ENST00000249284.2	-	1	132	c.67G>T	c.(67-69)Gtg>Ttg	p.V23L		NM_016945.2	NP_058641.1	Q9NYV7	T2R16_HUMAN	taste receptor, type 2, member 16	23					detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CTGCTCTGCACAATAATTGTC	0.473000													23	178					7.92952e-12	9.38392e-12	0.294199	1	0
CNNM2	54805	broad.mit.edu	37	10	104679104	104679104	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:104679104C>T	ENST00000369878.3	+	1	991	c.867C>T	c.(865-867)atC>atT	p.I289I	CNNM2_ENST00000433628.2_Silent_p.I289I|CNNM2_ENST00000369875.3_Silent_p.I289I|CNNM2_ENST00000457502.2_Silent_p.I47I	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	289	DUF21.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		AGCTGCGCATCGTGCAGAACT	0.627000													13	17					0	0	0.119110	0	0
CD1B	910	broad.mit.edu	37	1	158300748	158300748	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158300748G>T	ENST00000368168.3	-	2	273	c.166C>A	c.(166-168)Cat>Aat	p.H56N		NM_001764.2	NP_001755.1	P29016	CD1B_HUMAN	CD1b molecule	56					antigen processing and presentation|immune response	endosome membrane|integral to membrane|lysosomal membrane|plasma membrane	protein binding			breast(2)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	30	all_hematologic(112;0.0378)					TCCCAGCCATGAATCTGCAAA	0.493000													438	260					9.25978e-237	1.7286e-236	0.323286	1	0
OR5M10	390167	broad.mit.edu	37	11	56344651	56344651	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56344651G>C	ENST00000526812.2	-	1	612	c.547C>G	c.(547-549)Cct>Gct	p.P183A		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						ATGATAAGAGGAGGATCAGCG	0.458000													61	146					0	0	0.323286	0	0
PLCL1	5334	broad.mit.edu	37	2	198949322	198949322	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:198949322G>A	ENST00000428675.1	+	2	1479	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	PLCL1_ENST00000437704.2_Missense_Mutation_p.E263K	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	361					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	AAGGAGATACGAACTTTCTGA	0.388000													156	152					0	0	0.323286	0	0
AREL1	9870	broad.mit.edu	37	14	75130730	75130730	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:75130730C>A	ENST00000356357.4	-	19	2756	c.2241G>T	c.(2239-2241)gaG>gaT	p.E747D	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		GCCGAGCCAACTCCTCCTGGG	0.547000													17	34					9.04072e-19	1.18691e-18	0.183431	1	0
SALL4	57167	broad.mit.edu	37	20	50406738	50406738	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:50406738C>A	ENST00000217086.4	-	2	2395	c.2284G>T	c.(2284-2286)Gac>Tac	p.D762Y	SALL4_ENST00000371539.3_Intron|SALL4_ENST00000395997.3_Intron	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	762					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GAGGATGAGTCGTTGGTCAAG	0.572000													15	33					7.07596e-05	7.4589e-05	0.175082	1	0
DCC	1630	broad.mit.edu	37	18	50432543	50432543	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:50432543C>T	ENST00000442544.2	+	3	1158	c.542C>T	c.(541-543)aCt>aTt	p.T181I	DCC_ENST00000412726.1_Missense_Mutation_p.T29I	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	181	Ig-like C2-type 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CAAGACCTGACTCCAATCCCA	0.542000													14	106					0	0	0.146539	0	0
C12orf42	374470	broad.mit.edu	37	12	103699929	103699929	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:103699929C>A	ENST00000548048.1	-	8	749	c.253G>T	c.(253-255)Gag>Tag	p.E85*	C12orf42_ENST00000548883.1_Nonsense_Mutation_p.E152*|C12orf42_ENST00000378113.2_Nonsense_Mutation_p.E152*|C12orf42_ENST00000315192.8_Intron|C12orf42_ENST00000548789.1_5'UTR			Q96LP6	CL042_HUMAN	chromosome 12 open reading frame 42	152								p.E152Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)	22						CTGGCTCTCTCCTCAGTTTCT	0.458000													82	7					2.5963e-48	4.33932e-48	0.323286	1	0
C19orf52	90580	broad.mit.edu	37	19	11040235	11040235	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:11040235G>C	ENST00000270502.6	+	2	730	c.640G>C	c.(640-642)Gat>Cat	p.D214H		NM_138358.2	NP_612367.1	Q9BSF4	CS052_HUMAN	chromosome 19 open reading frame 52	214										prostate(1)	1						GCGGCTCTTCGATGAGAAGTA	0.617000													6	7					0	0	0.248553	0	0
DEFB115	245929	broad.mit.edu	37	20	29847318	29847318	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:29847318A>C	ENST00000400552.1	+	2	150	c.150A>C	c.(148-150)aaA>aaC	p.K50N		NM_001037730.1	NP_001032819.1	Q30KQ5	DB115_HUMAN	defensin, beta 115	50					defense response to bacterium	extracellular region				kidney(1)|lung(3)|ovary(1)|skin(1)	6			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			AATCATGCAAAGAAATTGAGA	0.338000													28	96					0	0	0.134883	0	0
SORCS3	22986	broad.mit.edu	37	10	106849559	106849559	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:106849559C>A	ENST00000369701.3	+	6	1282	c.1055C>A	c.(1054-1056)gCg>gAg	p.A352E		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	352						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GATAAGGAGGCGGACCTGGTG	0.597000													42	60					4.78724e-31	7.22167e-31	0.323286	1	0
PDGFD	80310	broad.mit.edu	37	11	103780540	103780540	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:103780540T>A	ENST00000302251.5	-	7	1428	c.977A>T	c.(976-978)cAg>cTg	p.Q326L	PDGFD_ENST00000393158.2_Missense_Mutation_p.Q332L	NM_025208.4|NM_033135.3	NP_079484.1|NP_149126.1	Q9GZP0	PDGFD_HUMAN	platelet derived growth factor D	332					positive regulation of cell division	endoplasmic reticulum lumen|extracellular region|Golgi membrane	growth factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Melanoma(852;0.0563)|all_neural(303;0.165)		BRCA - Breast invasive adenocarcinoma(274;0.00136)|Epithelial(105;0.111)		AGGCTCAAACTGTAATACCTA	0.448000													94	193					0	0	0.323286	0	0
OR10A5	144124	broad.mit.edu	37	11	6867317	6867317	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:6867317T>G	ENST00000299454.4	+	1	435	c.404T>G	c.(403-405)gTc>gGc	p.V135G	OR10A5_ENST00000379831.2_Missense_Mutation_p.V139G			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	135					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CACTACCCAGTCATCATGAAC	0.512000													52	127					0	0	0.323286	0	0
ERN1	2081	broad.mit.edu	37	17	62122776	62122776	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:62122776C>A	ENST00000433197.2	-	20	2691	c.2596G>T	c.(2596-2598)Ggg>Tgg	p.G866W		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	866	KEN.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						ACGGCTCTCCCGCCTCTCTCT	0.557000													47	32					4.13886e-29	6.1184e-29	0.323286	1	0
A2ML1	144568	broad.mit.edu	37	12	9002792	9002792	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:9002792C>A	ENST00000299698.7	+	18	2336	c.2156C>A	c.(2155-2157)aCt>aAt	p.T719N	A2ML1_ENST00000539547.1_Missense_Mutation_p.T228N	NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	563						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						GAGTCATCAACTCCTTTACAT	0.448000													180	499					1.86033e-102	3.40109e-102	0.323286	1	0
KMT2D	8085	broad.mit.edu	37	12	49420124	49420124	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:49420124C>A	ENST00000301067.7	-	48	15624	c.15625G>T	c.(15625-15627)Ggc>Tgc	p.G5209C		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GCCTCGTAGCCCACGGGATAG	0.592000													26	46					6.12954e-19	8.06422e-19	0.309145	1	0
MUC17	140453	broad.mit.edu	37	7	100678788	100678788	+	Missense_Mutation	SNP	A	A	G	rs145039008		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100678788A>G	ENST00000306151.4	+	3	4155	c.4091A>G	c.(4090-4092)aAc>aGc	p.N1364S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1364	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTTGACAACAGCACACCT	0.458000													53	262					0	0	0.323286	0	0
TPTE	7179	broad.mit.edu	37	21	10952930	10952930	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:10952930T>C	ENST00000298232.7	-	8	580	c.213A>G	c.(211-213)gtA>gtG	p.V71V	TPTE_ENST00000342420.5_Silent_p.V51V|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Silent_p.V89V	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	89					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CAAAGGATGATACAATTGAAT	0.333000													3	32					0	0	0.150653	0	0
PLA2R1	22925	broad.mit.edu	37	2	160813135	160813135	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:160813135G>T	ENST00000283243.7	-	21	3114	c.2908C>A	c.(2908-2910)Ctt>Att	p.L970I	PLA2R1_ENST00000392771.1_Missense_Mutation_p.L970I	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	970	C-type lectin 6.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						TTCAGCAGAAGGCACTATCAA	0.393000													16	201					6.94344e-10	7.90582e-10	0.175082	1	0
OR5M9	390162	broad.mit.edu	37	11	56230560	56230560	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56230560G>A	ENST00000279791.1	-	1	317	c.318C>T	c.(316-318)gtC>gtT	p.V106V		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					CCTCCACGTGGACAACGGCAA	0.473000													132	100					0	0	0.323286	0	0
NAV3	89795	broad.mit.edu	37	12	78513494	78513494	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:78513494C>T	ENST00000397909.2	+	15	3691	c.3518C>T	c.(3517-3519)gCc>gTc	p.A1173V	NAV3_ENST00000536525.2_Missense_Mutation_p.A1173V|NAV3_ENST00000228327.6_Missense_Mutation_p.A1173V|NAV3_ENST00000266692.7_Missense_Mutation_p.A1173V			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1173	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCTGCTGGGGCCACCACCTCG	0.532000										HNSCC(70;0.22)			80	9					0	0	0.323286	0	0
RIMS2	9699	broad.mit.edu	37	8	104898178	104898178	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:104898178A>T	ENST00000507740.1	+	2	1011	c.775A>T	c.(775-777)Act>Tct	p.T259S	RIMS2_ENST00000406091.3_Missense_Mutation_p.T451S|RIMS2_ENST00000436393.2_Missense_Mutation_p.T229S|RIMS2_ENST00000262231.10_Missense_Mutation_p.T259S	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	482					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CTTGAGGCGTACTGACTCACT	0.463000										HNSCC(12;0.0054)			63	65					0	0	0.323286	0	0
MYL7	58498	broad.mit.edu	37	7	44179969	44179969	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:44179969G>T	ENST00000458240.1	-	3	458	c.170C>A	c.(169-171)cCc>cAc	p.P57H	MYL7_ENST00000223364.3_Missense_Mutation_p.P84H|MYL7_ENST00000434895.1_5'UTR			Q01449	MLRA_HUMAN	myosin, light chain 7, regulatory	84	EF-hand 1.				actin filament-based movement|smooth muscle contraction	A band|myosin complex	ATPase activity, coupled|calcium ion binding|microfilament motor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	12						GAAGTTGATGGGGCCCTTGCC	0.642000													33	99					4.67007e-22	6.42238e-22	0.268233	1	0
SLC43A3	29015	broad.mit.edu	37	11	57193471	57193471	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:57193471C>A	ENST00000395123.2	-	3	479	c.175G>T	c.(175-177)Ggg>Tgg	p.G59W	SLC43A3_ENST00000395124.1_Missense_Mutation_p.G59W|SLC43A3_ENST00000529554.1_Missense_Mutation_p.G59W|SLC43A3_ENST00000352187.1_Missense_Mutation_p.G59W|SLC43A3_ENST00000528098.1_5'UTR|SLC43A3_ENST00000533524.1_Missense_Mutation_p.G59W	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	59					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						CCAGCCTGCCCTGTGGCATTG	0.542000													68	148					3.71514e-35	5.80807e-35	0.323286	1	0
ARHGAP32	9743	broad.mit.edu	37	11	128994766	128994766	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:128994766C>A	ENST00000310343.9	-	3	248	c.249G>T	c.(247-249)gaG>gaT	p.E83D	ARHGAP32_ENST00000524655.1_Missense_Mutation_p.E9D	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	83					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CTCCAGGAATCTCTGGAACAT	0.333000													52	124					7.10663e-31	1.07049e-30	0.323286	1	0
GPRIN1	114787	broad.mit.edu	37	5	176026278	176026278	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:176026278C>A	ENST00000303991.4	-	2	735	c.558G>T	c.(556-558)gaG>gaT	p.E186D		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	186						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGATTTCAGGCTCTGCCTTTC	0.502000													27	33					1.45844e-13	1.78036e-13	0.173368	1	0
PLEKHG2	64857	broad.mit.edu	37	19	39914598	39914598	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:39914598G>A	ENST00000425673.1	+	17	3063	c.2738G>A	c.(2737-2739)gGa>gAa	p.G913E	PLEKHG2_ENST00000409797.2_Intron|PLEKHG2_ENST00000378550.1_Intron|PLEKHG2_ENST00000458508.2_Missense_Mutation_p.G883E|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.G942E			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	942					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CCTGAGCAAGGAGGTTCCCGG	0.582000													74	49					0	0	0.323286	0	0
OR2G2	81470	broad.mit.edu	37	1	247752548	247752548	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247752548G>C	ENST00000320065.1	+	1	887	c.887G>C	c.(886-888)aGg>aCg	p.R296T	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	296					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TATACCTTGAGGATCAAGGAG	0.408000													89	269					0	0	0.323286	0	0
BBS10	79738	broad.mit.edu	37	12	76740920	76740920	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:76740920T>A	ENST00000393262.3	-	2	928	c.845A>T	c.(844-846)cAg>cTg	p.Q282L		NM_024685.3	NP_078961.3	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	282					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)	19						TGTCTGAAACTGTGCTTCTGA	0.363000									Bardet-Biedl syndrome				8	13					0	0	0.278610	0	0
FRYL	285527	broad.mit.edu	37	4	48569380	48569380	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:48569380A>G	ENST00000537810.1	-	28	3658	c.3054T>C	c.(3052-3054)taT>taC	p.Y1018Y	FRYL_ENST00000507711.1_Silent_p.Y1018Y|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000503238.1_Silent_p.Y1018Y|FRYL_ENST00000358350.4_Silent_p.Y1018Y			O94915	FRYL_HUMAN	FRY-like	1018					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						TTAAATCTACATATTCCAATA	0.348000													23	22					0	0	0.279207	0	0
ZNF621	285268	broad.mit.edu	37	3	40573774	40573774	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:40573774G>T	ENST00000339296.5	+	5	965	c.513G>T	c.(511-513)atG>atT	p.M171I	ZNF621_ENST00000431278.1_Missense_Mutation_p.M60I|ZNF621_ENST00000403205.2_Missense_Mutation_p.M171I|ZNF621_ENST00000490457.1_Intron|ZNF621_ENST00000310898.1_Intron	NM_198484.3	NP_940886.1	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		GGCATCAGATGAGTCATACTG	0.383000													39	87					1.07121e-22	1.48635e-22	0.246493	1	0
ZXDC	79364	broad.mit.edu	37	3	126157259	126157259	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:126157259G>C	ENST00000389709.3	-	10	2589	c.2536C>G	c.(2536-2538)Cag>Gag	p.Q846E		NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	846	Interaction with CIITA.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		CCTGGGAACTGGGTGGCCTCC	0.627000													24	23					0	0	0.294199	0	0
ITFG1	81533	broad.mit.edu	37	16	47294485	47294485	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:47294485C>A	ENST00000320640.6	-	11	1420	c.1192G>T	c.(1192-1194)Gtt>Ttt	p.V398F	ITFG1_ENST00000544001.2_Missense_Mutation_p.V285F|ITFG1_ENST00000568047.1_5'UTR	NM_030790.3	NP_110417.2	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	398						extracellular region|integral to membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	19		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				AAGGTGGCAACCATGGCATCC	0.438000													51	9					6.77423e-14	8.30225e-14	0.323286	1	0
SSX9	280660	broad.mit.edu	37	X	48163727	48163727	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:48163727A>G	ENST00000376909.1	-	3	181	c.119T>C	c.(118-120)aTg>aCg	p.M40T	SSX9_ENST00000407081.2_Missense_Mutation_p.M40T																breast(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|stomach(1)	8						CGAGGATTTCATCTTTTCCCA	0.388000													72	136					0	0	0.323286	0	0
ANKRD45	339416	broad.mit.edu	37	1	173628467	173628467	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:173628467C>T	ENST00000333279.2	-	2	151	c.91G>A	c.(91-93)Gag>Aag	p.E31K		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	47										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						CCTGTttcctctggttcttgg	0.448000													19	46					0	0	0.189662	0	0
QDPR	5860	broad.mit.edu	37	4	17510984	17510984	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:17510984C>G	ENST00000281243.5	-	2	287	c.108G>C	c.(106-108)tgG>tgC	p.W36C	QDPR_ENST00000508623.1_Missense_Mutation_p.W36C|QDPR_ENST00000428702.2_Intron|QDPR_ENST00000513615.1_Missense_Mutation_p.W36C	NM_000320.2	NP_000311.2	P09417	DHPR_HUMAN	quinoid dihydropteridine reductase	36			W -> R (in HPABH4C).		dihydrobiopterin metabolic process|L-phenylalanine catabolic process|tetrahydrobiopterin biosynthetic process	cytosol	6,7-dihydropteridine reductase activity|binding|electron carrier activity			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	13					NADH(DB00157)	CGCTGGCAACCCACTGGAAGG	0.473000													23	46					0	0	0.125774	0	0
MYOD1	4654	broad.mit.edu	37	11	17741528	17741528	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:17741528G>T	ENST00000250003.3	+	1	414	c.199G>T	c.(199-201)Gcg>Tcg	p.A67S		NM_002478.4	NP_002469.2	P15172	MYOD1_HUMAN	myogenic differentiation 1	67					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	17						GCACTTCCCCGCGGCGGTGCA	0.716000													23	2					4.22769e-11	4.94642e-11	0.116897	1	0
KLK4	9622	broad.mit.edu	37	19	51412525	51412525	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51412525G>T	ENST00000324041.1	-	2	206	c.207C>A	c.(205-207)gcC>gcA	p.A69A	KLK4_ENST00000431178.2_Silent_p.A20A	NM_004917.3	NP_004908.3	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4	69	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(8)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		AACAGTGTGCGGCTGACAGCA	0.642000													52	100					2.01871e-26	2.91059e-26	0.323286	1	0
FMR1	2332	broad.mit.edu	37	X	147024765	147024765	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:147024765G>T	ENST00000218200.8	+	13	1556	c.1327G>T	c.(1327-1329)Gat>Tat	p.D443Y	FMR1_ENST00000370477.1_Missense_Mutation_p.D443Y|FMR1_ENST00000370471.3_Intron|FMR1_ENST00000370475.4_Missense_Mutation_p.D464Y|FMR1_ENST00000439526.2_Missense_Mutation_p.D441Y|FMR1_ENST00000492846.1_3'UTR|FMR1_ENST00000440235.2_Missense_Mutation_p.D111Y|FMR1_ENST00000370470.1_Missense_Mutation_p.D464Y	NM_001185076.1|NM_001185082.1	NP_001172005.1|NP_001172011.1	Q06787	FMR1_HUMAN	fragile X mental retardation 1	464	Interaction with RANBP9.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			NS(1)|breast(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	35	Acute lymphoblastic leukemia(192;6.56e-05)					CTATGTGACTGATGATGGTCA	0.448000									Fragile X syndrome				84	5					3.76144e-29	5.56844e-29	0.323286	1	0
HMCN1	83872	broad.mit.edu	37	1	186050512	186050512	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:186050512G>T	ENST00000271588.4	+	56	9002	c.8773G>T	c.(8773-8775)Gga>Tga	p.G2925*	HMCN1_ENST00000367492.2_Nonsense_Mutation_p.G2925*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	2925	Ig-like C2-type 27.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TCTATCTAATGGACGAATTCT	0.343000													118	232					1.17312e-48	1.96599e-48	0.323286	1	0
LINC01410	103352539	broad.mit.edu	37	9	66459813	66459813	+	RNA	SNP	G	G	A	rs10752517	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:66459813G>A	ENST00000424345.1	+	0	73																											tccaggatttgtccccagtgc	0.343000													4	33					0	0	0.217242	0	0
EPHA4	2043	broad.mit.edu	37	2	222307584	222307584	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:222307584G>T	ENST00000281821.2	-	11	2080	c.2039C>A	c.(2038-2040)cCg>cAg	p.P680Q	EPHA4_ENST00000392071.4_Missense_Mutation_p.P629Q|EPHA4_ENST00000409938.1_Missense_Mutation_p.P680Q|EPHA4_ENST00000409854.1_Missense_Mutation_p.P680Q	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	680	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		AATGATGTTCGGATGGTCAAA	0.458000													47	140					4.18559e-23	5.83908e-23	0.323286	1	0
DOCK8	81704	broad.mit.edu	37	9	420997	420997	+	Silent	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:420997A>C	ENST00000432829.2	+	32	4184	c.3868A>C	c.(3868-3870)Agg>Cgg	p.R1290R	DOCK8_ENST00000469391.1_Silent_p.R1258R|DOCK8_ENST00000453981.1_Silent_p.R1358R|DOCK8_ENST00000382329.1_Silent_p.R825R|DOCK8_ENST00000493666.2_3'UTR	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1358					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GCAGAAGTCAAGGGATGTCAA	0.572000													39	160					0	0	0.312237	0	0
C2orf62	375307	broad.mit.edu	37	2	219232596	219232596	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:219232596G>A	ENST00000289388.3	+	10	1102	c.1073G>A	c.(1072-1074)cGt>cAt	p.R358H	C2orf62_ENST00000481940.1_3'UTR	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	358										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GACCCGTGGCGTCCGTCGTCA	0.721000													10	13					0	0	0.175082	0	0
GLRA1	2741	broad.mit.edu	37	5	151271938	151271938	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:151271938C>A	ENST00000274576.4	-	2	410	c.118G>T	c.(118-120)Gat>Tat	p.D40Y	GLRA1_ENST00000455880.2_Missense_Mutation_p.D40Y|GLRA1_ENST00000471351.2_5'UTR|GLRA1_ENST00000545569.1_Intron	NM_000171.3|NM_001146040.1	NP_000162.2|NP_001139512.1	P23415	GLRA1_HUMAN	glycine receptor, alpha 1	40					muscle contraction|negative regulation of transmission of nerve impulse|neuropeptide signaling pathway|positive regulation of acrosome reaction|regulation of membrane potential|startle response	cell junction|chloride channel complex|integral to plasma membrane|intracellular membrane-bounded organelle|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|protein binding|receptor activity|taurine binding|transmitter-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	23		all_hematologic(541;0.0341)|Medulloblastoma(196;0.0912)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Ethanol(DB00898)|Glycine(DB00145)|Halothane(DB01159)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCCAGGAAATCCGAGGGTGAC	0.502000													84	89					2.77303e-49	4.65478e-49	0.323286	1	0
MIA3	375056	broad.mit.edu	37	1	222803008	222803008	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:222803008C>G	ENST00000344922.5	+	4	2471	c.2446C>G	c.(2446-2448)Ctg>Gtg	p.L816V	MIA3_ENST00000344441.6_Missense_Mutation_p.L816V|MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	816					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		AGAACGCCCTCTGGCAGATAA	0.413000													45	86					0	0	0.279185	0	0
NFATC2IP	84901	broad.mit.edu	37	16	28967297	28967297	+	Splice_Site	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:28967297A>T	ENST00000320805.4	+	4	653		c.e4-1		NFATC2IP_ENST00000562977.1_Intron|NFATC2IP_ENST00000564978.1_Intron	NM_032815.3	NP_116204.3	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein							cytoplasm|nucleus				breast(1)|endometrium(2)|large_intestine(1)|lung(5)|ovary(2)	11						TTGCTTCTACAGGGATCTGGA	0.522000													4	274					0	0	0.150653	0	0
C2orf62	375307	broad.mit.edu	37	2	219222789	219222789	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:219222789G>T	ENST00000289388.3	+	4	378	c.349G>T	c.(349-351)Gaa>Taa	p.E117*	C2orf62_ENST00000481940.1_3'UTR	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	117										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGCTCATGGAACAGCACAG	0.532000													8	44					1.08611e-07	1.19026e-07	0.080935	1	0
SPANXN2	494119	broad.mit.edu	37	X	142803690	142803690	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:142803690C>A	ENST00000370498.1	-	1	826	c.73G>T	c.(73-75)Gat>Tat	p.D25Y		NM_001009615.1	NP_001009615.1	Q5MJ10	SPXN2_HUMAN	SPANX family, member N2	25										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					CTTACCTCATCATTTTTTTTG	0.443000													27	1					3.69857e-22	5.10221e-22	0.134883	1	0
NTRK2	4915	broad.mit.edu	37	9	87635234	87635234	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:87635234T>G	ENST00000376214.1	+	20	3224	c.2286T>G	c.(2284-2286)atT>atG	p.I762M	NTRK2_ENST00000376213.1_Missense_Mutation_p.I746M|NTRK2_ENST00000323115.4_Missense_Mutation_p.I746M|NTRK2_ENST00000277120.3_Missense_Mutation_p.I762M	NM_006180.3	NP_006171.2	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	746	Protein kinase.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						TGTGGGAGATTTTCACCTATG	0.557000										TSP Lung(25;0.17)			152	175					0	0	0.323286	0	0
KALRN	8997	broad.mit.edu	37	3	124165685	124165685	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:124165685A>T	ENST00000360013.3	+	21	3626	c.3499A>T	c.(3499-3501)Act>Tct	p.T1167S	KALRN_ENST00000240874.3_Missense_Mutation_p.T1167S|KALRN_ENST00000460856.1_Missense_Mutation_p.T1158S	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1167					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CACAGAGGAGACTCAGGAACT	0.512000													202	396					0	0	0.323286	0	0
ERG	2078	broad.mit.edu	37	21	39795437	39795437	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:39795437C>A	ENST00000442448.1	-	5	575	c.304G>T	c.(304-306)Ggc>Tgc	p.G102C	ERG_ENST00000398910.1_Missense_Mutation_p.G102C|ERG_ENST00000398905.1_Missense_Mutation_p.G95C|ERG_ENST00000453032.2_Missense_Mutation_p.G3C|ERG_ENST00000398911.1_Missense_Mutation_p.G102C|ERG_ENST00000398907.1_Missense_Mutation_p.G95C|ERG_ENST00000398897.1_Missense_Mutation_p.G3C|ERG_ENST00000429727.2_Missense_Mutation_p.G95C|ERG_ENST00000288319.7_Missense_Mutation_p.G95C|ERG_ENST00000417133.2_Missense_Mutation_p.G102C|ERG_ENST00000398919.2_Missense_Mutation_p.G102C	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	102					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				TCTGGGCTGCCCACCATCTTC	0.522000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								59	3					7.73544e-29	1.14079e-28	0.323286	1	0
MGAM	8972	broad.mit.edu	37	7	141719105	141719105	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:141719105T>G	ENST00000475668.2	+	4	488	c.434T>G	c.(433-435)gTc>gGc	p.V145G	MGAM_ENST00000549489.2_Missense_Mutation_p.V145G			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	145					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GGCAACCTTGTCAACACAAAT	0.537000													37	133					0	0	0.214465	0	0
FAT3	120114	broad.mit.edu	37	11	92616192	92616192	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:92616192G>T	ENST00000298047.6	+	23	12587	c.12570G>T	c.(12568-12570)acG>acT	p.T4190T	FAT3_ENST00000525166.1_Silent_p.T4040T|FAT3_ENST00000409404.2_Silent_p.T4190T|FAT3_ENST00000533797.1_Silent_p.T525T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4190					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ACAACATCACGCTAGTGCAGG	0.597000										TCGA Ovarian(4;0.039)			12	36					4.14922e-12	4.93476e-12	0.146539	1	0
RNASE10	338879	broad.mit.edu	37	14	20978700	20978700	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20978700G>T	ENST00000430083.1	+	2	558	c.154G>T	c.(154-156)Ggg>Tgg	p.G52W	RNASE10_ENST00000328444.5_Missense_Mutation_p.G24W			Q5GAN6	RNS10_HUMAN	ribonuclease, RNase A family, 10 (non-active)	24						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(2)|lung(8)|urinary_tract(1)	12	all_cancers(95;0.00123)		Epithelial(56;1.81e-07)|all cancers(55;1.86e-06)	GBM - Glioblastoma multiforme(265;0.022)|READ - Rectum adenocarcinoma(17;0.191)		gatgggcctggggttgggact	0.517000													135	91					9.82513e-110	1.80584e-109	0.323286	1	0
SPATA31C1	441452	broad.mit.edu	37	9	90535243	90535243	+	RNA	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:90535243A>C	ENST00000602681.1	+	0	1147																											GGTGGGCAAAAGAACACCTGA	0.587000													84	141					0	0	0.323286	0	0
KYNU	8942	broad.mit.edu	37	2	143742745	143742745	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:143742745C>T	ENST00000264170.4	+	9	1080	c.822C>T	c.(820-822)tcC>tcT	p.S274S	KYNU_ENST00000375773.2_Silent_p.S274S|KYNU_ENST00000409512.1_Silent_p.S274S	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	274					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	GCTGGTGTTCCTACAAGGTAC	0.393000													21	97					0	0	0.219247	0	0
OR9I1	219954	broad.mit.edu	37	11	57885982	57885982	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:57885982A>C	ENST00000302610.1	-	1	934	c.935T>G	c.(934-936)cTg>cGg	p.L312R	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				CTACATGCTCAGGGACACCTG	0.423000													43	385					0	0	0.323286	0	0
KIAA1598	57698	broad.mit.edu	37	10	118689514	118689514	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:118689514C>A	ENST00000355371.4	-	10	1356		c.e10-1		KIAA1598_ENST00000497044.1_Splice_Site|KIAA1598_ENST00000260777.10_Splice_Site|KIAA1598_ENST00000392903.2_Splice_Site|KIAA1598_ENST00000392901.4_Splice_Site	NM_001127211.2|NM_001258298.1|NM_001258299.1	NP_001120683.1|NP_001245227.1|NP_001245228.1	A0MZ66	SHOT1_HUMAN	KIAA1598						axon guidance	axon				endometrium(1)|kidney(1)|large_intestine(5)|lung(3)	10				all cancers(201;0.00494)		ATTCTTTGACCTATAAGTTAT	0.313000													47	7					6.31075e-24	8.87978e-24	0.323286	1	0
ACSS2	55902	broad.mit.edu	37	20	33513944	33513944	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:33513944T>C	ENST00000360596.2	+	16	1974	c.1763T>C	c.(1762-1764)cTt>cCt	p.L588P	ACSS2_ENST00000336325.4_Missense_Mutation_p.L538P|ACSS2_ENST00000253382.5_Missense_Mutation_p.L601P|ACSS2_ENST00000476922.1_Intron	NM_018677.3	NP_061147.1	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	588					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(9)	21					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GAGTCAGCACTTGTGGAACAT	0.567000													29	297					0	0	0.312237	0	0
MUC17	140453	broad.mit.edu	37	7	100680177	100680177	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100680177C>A	ENST00000306151.4	+	3	5544	c.5480C>A	c.(5479-5481)aCc>aAc	p.T1827N		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1827	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GAGGCTAGCACCCTTTCAACA	0.498000													88	114					5.01286e-43	8.21854e-43	0.323286	1	0
WDR49	151790	broad.mit.edu	37	3	167246875	167246875	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:167246875C>A	ENST00000308378.3	-	10	1620	c.1315G>T	c.(1315-1317)Gat>Tat	p.D439Y	WDR49_ENST00000453925.2_Missense_Mutation_p.D503Y|WDR49_ENST00000476376.1_Missense_Mutation_p.D264Y|WDR49_ENST00000479765.1_Intron	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	439										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CCATCAAGATCTCCTGTGGTA	0.343000													49	121					6.3008e-33	9.6986e-33	0.323286	1	0
ARSF	416	broad.mit.edu	37	X	3002284	3002284	+	Splice_Site	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:3002284G>C	ENST00000381127.1	+	6	628	c.406_splice	c.e6-1	p.G136_splice	ARSF_ENST00000537104.1_Splice_Site_p.G136_splice|ARSF_ENST00000359361.2_Splice_Site_p.G136_splice	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	136						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTGGTTTTAGGCAAATGGCAC	0.443000													33	4					0	0	0.183431	0	0
ADAM22	53616	broad.mit.edu	37	7	87737491	87737491	+	Splice_Site	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:87737491G>A	ENST00000398204.4	+	5	714	c.390_splice	c.e5-1	p.G131_splice	ADAM22_ENST00000398201.4_Splice_Site_p.G131_splice|ADAM22_ENST00000265727.7_Splice_Site_p.G131_splice|ADAM22_ENST00000398209.3_Splice_Site_p.G131_splice|ADAM22_ENST00000439864.1_Splice_Site_p.G131_splice|ADAM22_ENST00000315984.7_Splice_Site_p.G131_splice	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	131					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			CTGTTTTCAGGGAGGAGAGCA	0.433000													15	48					0	0	0.160694	0	0
MS4A3	932	broad.mit.edu	37	11	59834493	59834493	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:59834493C>G	ENST00000278865.3	+	5	494	c.421C>G	c.(421-423)Cta>Gta	p.L141V	MS4A3_ENST00000395032.2_Missense_Mutation_p.L18V|MS4A3_ENST00000534744.1_Missense_Mutation_p.L95V|MS4A3_ENST00000358152.2_Missense_Mutation_p.L95V	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	141						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				TTTTCTCTCACTAAATATAGC	0.353000													26	22					0	0	0.309145	0	0
MMRN1	22915	broad.mit.edu	37	4	90830522	90830522	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:90830522G>T	ENST00000394980.1	+	3	1038	c.719G>T	c.(718-720)tGg>tTg	p.W240L	MMRN1_ENST00000394981.1_Missense_Mutation_p.W206L|MMRN1_ENST00000264790.2_Missense_Mutation_p.W240L|MMRN1_ENST00000508372.1_5'UTR			Q13201	MMRN1_HUMAN	multimerin 1	240	EMI.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CCTTGTGGCTGGACCGGTGGA	0.413000													41	21					4.44401e-20	5.95033e-20	0.290176	1	0
LRRC4B	94030	broad.mit.edu	37	19	51021166	51021166	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51021166G>T	ENST00000599957.1	-	3	2001	c.1804C>A	c.(1804-1806)Cag>Aag	p.Q602K	LRRC4B_ENST00000389201.3_Missense_Mutation_p.Q602K			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	602						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		AGCTGGTGCTGCTTGCGCAGC	0.647000													21	10					2.98393e-07	3.2574e-07	0.264190	1	0
ZNF683	257101	broad.mit.edu	37	1	26691442	26691442	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:26691442G>C	ENST00000436292.1	-	4	715	c.595C>G	c.(595-597)Ctc>Gtc	p.L199V	ZNF683_ENST00000403843.1_Missense_Mutation_p.L199V|ZNF683_ENST00000374204.1_Missense_Mutation_p.L199V|ZNF683_ENST00000349618.3_Missense_Mutation_p.L199V			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGAGGCAGGAGAAGTGGGTAT	0.617000													17	42					0	0	0.175082	0	0
ITGAX	3687	broad.mit.edu	37	16	31372528	31372528	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:31372528A>T	ENST00000268296.4	+	9	1127	c.1006A>T	c.(1006-1008)Att>Ttt	p.I336F	ITGAX_ENST00000562522.1_Missense_Mutation_p.I336F	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	336	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						GATCTTTGCCATTGAGGGTGA	0.478000													51	2					0	0	0.323286	0	0
BAIAP3	8938	broad.mit.edu	37	16	1394694	1394694	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:1394694C>A	ENST00000324385.5	+	19	2015	c.1857C>A	c.(1855-1857)ttC>ttA	p.F619L	BAIAP3_ENST00000562208.1_Missense_Mutation_p.F561L|BAIAP3_ENST00000568887.1_Missense_Mutation_p.F556L|BAIAP3_ENST00000397488.2_Missense_Mutation_p.F601L|BAIAP3_ENST00000426824.3_Missense_Mutation_p.F584L|BAIAP3_ENST00000421665.2_Missense_Mutation_p.F548L|BAIAP3_ENST00000397489.1_Missense_Mutation_p.F601L	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	619					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				CCAGCCTCTTCCACAGGTGGG	0.647000													9	1					1.96292e-10	2.25656e-10	0.219247	1	0
C1orf168	199920	broad.mit.edu	37	1	57185863	57185863	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:57185863C>A	ENST00000343433.6	-	18	2194	c.2114G>T	c.(2113-2115)cGt>cTt	p.R705L		NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	705										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TTTAGAATTACGACATATCAC	0.264000													10	65					2.80697e-09	3.15772e-09	0.080935	1	0
SLC35G5	83650	broad.mit.edu	37	8	11188988	11188988	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:11188988G>T	ENST00000382435.4	+	1	592	c.373G>T	c.(373-375)Gtg>Ttg	p.V125L		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	125	DUF6 1.					integral to membrane											AGTTCAGGTGGTGCCCGCTGG	0.617000													69	10					3.28884e-47	5.47315e-47	0.323286	1	0
KLHDC10	23008	broad.mit.edu	37	7	129770407	129770407	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:129770407G>T	ENST00000335420.5	+	10	1284	c.1150G>T	c.(1150-1152)Gtg>Ttg	p.V384L		NM_014997.3	NP_055812.1	Q6PID8	KLD10_HUMAN	kelch domain containing 10	384										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|liver(2)|lung(10)|prostate(1)	17						TGGAGGAGTGGTGAACATCCA	0.483000													49	161					6.31075e-24	8.87978e-24	0.323286	1	0
ZNF10	7556	broad.mit.edu	37	12	133732556	133732556	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:133732556G>C	ENST00000248211.6	+	5	946	c.724G>C	c.(724-726)Gat>Cat	p.D242H	ZNF268_ENST00000416488.1_Intron|ZNF10_ENST00000402932.2_Intron|ZNF10_ENST00000426665.2_Missense_Mutation_p.D242H|CTD-2140B24.4_ENST00000540096.2_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	242				Missing (in Ref. 1).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CAAATGCCCTGATAATGACAA	0.368000													17	49					0	0	0.204396	0	0
LRRTM4	80059	broad.mit.edu	37	2	77745714	77745714	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:77745714G>T	ENST00000409088.3	-	3	1695	c.1281C>A	c.(1279-1281)gcC>gcA	p.A427A	LRRTM4_ENST00000409884.1_Silent_p.A427A|LRRTM4_ENST00000409911.1_Silent_p.A428A|LRRTM4_ENST00000409282.1_Silent_p.A428A|LRRTM4_ENST00000409093.1_Silent_p.A427A	NM_024993.4	NP_079269.4	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	427						integral to membrane				autonomic_ganglia(1)|endometrium(1)|large_intestine(6)|lung(49)|ovary(2)|pancreas(3)|prostate(1)|upper_aerodigestive_tract(1)	64				Colorectal(11;0.059)		CCACACTCCCGGCAATAATTT	0.488000													70	76					4.49761e-31	6.79138e-31	0.323286	1	0
HRNR	388697	broad.mit.edu	37	1	152192919	152192919	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152192919G>A	ENST00000368801.2	-	3	1261	c.1186C>T	c.(1186-1188)Cag>Tag	p.Q396*	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	396					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGAAGACTGACGTGAGCTG	0.597000													15	23					0	0	0.132662	0	0
MRTO4	51154	broad.mit.edu	37	1	19582447	19582447	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:19582447G>T	ENST00000330263.4	+	3	390	c.93G>T	c.(91-93)cgG>cgT	p.R31R	MRTO4_ENST00000493700.1_3'UTR	NM_016183.3	NP_057267.2	Q9UKD2	MRT4_HUMAN	mRNA turnover 4 homolog (S. cerevisiae)	31					ribosome biogenesis	nuclear membrane|nucleolus				breast(1)|endometrium(1)|large_intestine(1)|liver(2)|ovary(1)|pancreas(1)|stomach(1)	8		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|BRCA - Breast invasive adenocarcinoma(304;1.87e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00301)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		CACAGCTTCGGAAATGTGTGG	0.532000													3	24					0.000602214	0.000625229	0.184627	1	0
DNAH7	56171	broad.mit.edu	37	2	196729269	196729269	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:196729269C>A	ENST00000312428.6	-	41	7210	c.7110G>T	c.(7108-7110)ggG>ggT	p.G2370G		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2370	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TAGTATCATACCCCTTAGAGA	0.433000													106	110					3.00942e-58	5.23605e-58	0.323286	1	0
GIMAP2	26157	broad.mit.edu	37	7	150389579	150389579	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:150389579G>T	ENST00000223293.5	+	3	299	c.205G>T	c.(205-207)Gga>Tga	p.G69*		NM_015660.2	NP_056475.1	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	69						integral to membrane	GTP binding			kidney(1)|large_intestine(1)|lung(8)|skin(2)|urinary_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGAAGCTGGGGAAATAGAGA	0.473000													33	133					1.57351e-24	2.22519e-24	0.193644	1	0
FCRL4	83417	broad.mit.edu	37	1	157548295	157548295	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157548295G>C	ENST00000271532.1	-	10	1533	c.1398C>G	c.(1396-1398)atC>atG	p.I466M	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	466						integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GAGTAGTCTGGATCTCAGAGT	0.408000													28	108					0	0	0.163468	0	0
NTNG1	22854	broad.mit.edu	37	1	107867442	107867442	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:107867442T>A	ENST00000370067.1	+	3	1412	c.785T>A	c.(784-786)cTg>cAg	p.L262Q	NTNG1_ENST00000370065.1_Missense_Mutation_p.L262Q|NTNG1_ENST00000477948.1_3'UTR|NTNG1_ENST00000370061.3_Missense_Mutation_p.L262Q|NTNG1_ENST00000370072.3_Missense_Mutation_p.L262Q|NTNG1_ENST00000370070.2_Missense_Mutation_p.L262Q|NTNG1_ENST00000370066.1_Missense_Mutation_p.L262Q|NTNG1_ENST00000370074.4_Missense_Mutation_p.L262Q|NTNG1_ENST00000370073.2_Missense_Mutation_p.L262Q|NTNG1_ENST00000370068.1_Missense_Mutation_p.L262Q|NTNG1_ENST00000370071.2_Missense_Mutation_p.L262Q|NTNG1_ENST00000542803.1_Missense_Mutation_p.L262Q			Q9Y2I2	NTNG1_HUMAN	netrin G1	262	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GTCACAGACCTGAGGATAAGG	0.473000													81	30					0	0	0.323286	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37494471	37494471	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:37494471G>T	ENST00000381792.2	-	3	461	c.321C>A	c.(319-321)gcC>gcA	p.A107A	TMPRSS6_ENST00000442782.2_Silent_p.A116A|TMPRSS6_ENST00000406725.1_Silent_p.A107A|TMPRSS6_ENST00000406856.1_Silent_p.A107A|TMPRSS6_ENST00000346753.3_Silent_p.A116A			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	116					angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						TCTGGGCTTTGGCGGTTTCAC	0.562000													406	55					4.50054e-203	8.38135e-203	0.323286	1	0
TRPC4AP	26133	broad.mit.edu	37	20	33603840	33603840	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:33603840C>A	ENST00000252015.2	-	10	1410	c.1321G>T	c.(1321-1323)Ggt>Tgt	p.G441C	TRPC4AP_ENST00000539834.1_Missense_Mutation_p.G43C|TRPC4AP_ENST00000432634.2_Missense_Mutation_p.G402C|TRPC4AP_ENST00000451813.1_Missense_Mutation_p.G433C			Q8TEL6	TP4AP_HUMAN	transient receptor potential cation channel, subfamily C, member 4 associated protein	441					protein ubiquitination|ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex	protein binding			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|skin(1)|stomach(1)|urinary_tract(1)	32			BRCA - Breast invasive adenocarcinoma(18;0.00936)			TGGTTGTGACCATGGAGGACA	0.502000													55	49					4.1673e-28	6.10508e-28	0.323286	1	0
SGK1	6446	broad.mit.edu	37	6	134494448	134494448	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:134494448T>G	ENST00000367858.5	-	7	1263	c.666A>C	c.(664-666)aaA>aaC	p.K222N	SGK1_ENST00000413996.3_Missense_Mutation_p.K141N|SGK1_ENST00000528577.1_Missense_Mutation_p.K155N|SGK1_ENST00000367857.5_Missense_Mutation_p.K117N|SGK1_ENST00000237305.7_Missense_Mutation_p.K127N|SGK1_ENST00000475719.2_Missense_Mutation_p.K127N|SGK1_ENST00000489458.2_5'UTR	NM_001143676.1	NP_001137148.1	O00141	SGK1_HUMAN	serum/glucocorticoid regulated kinase 1	127	Protein kinase.				apoptosis|response to stress|sodium ion transport	endoplasmic reticulum|nucleus|plasma membrane	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(21)|kidney(3)|large_intestine(3)|lung(10)|ovary(1)|skin(4)|stomach(1)	46	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00317)|GBM - Glioblastoma multiforme(68;0.00847)		TCTGTAAAACTTTGACTGCAT	0.383000													23	62					0	0	0.324025	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68046582	68046582	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:68046582G>A	ENST00000329153.5	+	22	3304	c.3172G>A	c.(3172-3174)Gga>Aga	p.G1058R	PLEKHH1_ENST00000417684.2_5'UTR	NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	1058	FERM.					cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		CTGCCTGCAGGGAAGTGTCAA	0.602000													5	12					0	0	0.248553	0	0
OCLM	10896	broad.mit.edu	37	1	186370202	186370202	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:186370202T>G	ENST00000574641.1	+	1	499	c.25T>G	c.(25-27)Tta>Gta	p.L9V	C1orf27_ENST00000287859.6_Intron|C1orf27_ENST00000432021.3_Intron|C1orf27_ENST00000419367.3_Intron|C1orf27_ENST00000367470.3_Intron	NM_022375.3	NP_071770.1	Q9Y5M6	TISR_HUMAN	oculomedin	9					visual perception												ACCATTATTGTTAAAGATTTA	0.343000													31	342					0	0	0.279185	0	0
RIN2	54453	broad.mit.edu	37	20	19955660	19955660	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:19955660C>T	ENST00000255006.6	+	8	1287	c.1138C>T	c.(1138-1140)Cag>Tag	p.Q380*	RIN2_ENST00000484638.1_3'UTR|RIN2_ENST00000440354.2_Intron	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	331					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						GACTGAAACCCAGACGAGCAT	0.602000													60	43					0	0	0.323286	0	0
KRTAP10-11	386678	broad.mit.edu	37	21	46066914	46066914	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:46066914C>T	ENST00000334670.8	+	1	584	c.539C>T	c.(538-540)aCc>aTc	p.T180I	TSPEAR_ENST00000323084.4_Intron	NM_198692.2	NP_941965.2	P60411	KR109_HUMAN	keratin associated protein 10-11	174	25 X 5 AA repeats of C-C-X(3).					keratin filament				NS(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)	12						GCTTGCTGCACCTCCTCCTCC	0.597000													101	171					0	0	0.323286	0	0
ACSM4	341392	broad.mit.edu	37	12	7476108	7476108	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:7476108C>A	ENST00000399422.4	+	9	1308	c.1260C>A	c.(1258-1260)gcC>gcA	p.A420A		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	420					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						GGGAAATTGCCCTCAGACTCA	0.373000													33	134					7.11191e-15	8.85272e-15	0.173368	1	0
PDE8A	5151	broad.mit.edu	37	15	85626803	85626803	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:85626803C>T	ENST00000310298.4	+	7	815	c.563C>T	c.(562-564)cCc>cTc	p.P188L	PDE8A_ENST00000394553.1_Missense_Mutation_p.P188L|PDE8A_ENST00000339708.5_Missense_Mutation_p.P188L|PDE8A_ENST00000557957.1_Missense_Mutation_p.P116L|PDE8A_ENST00000557819.2_3'UTR			O60658	PDE8A_HUMAN	phosphodiesterase 8A	188					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	25	Colorectal(223;0.227)		BRCA - Breast invasive adenocarcinoma(143;0.0608)			GTAGAAAACCCCAACATCATG	0.398000													32	77					0	0	0.183431	0	0
IPO7	10527	broad.mit.edu	37	11	9435846	9435846	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:9435846A>T	ENST00000379719.3	+	5	666	c.524A>T	c.(523-525)cAg>cTg	p.Q175L		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	175					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		GCAGCAATGCAGCATTTTCTG	0.373000													15	44					0	0	0.132662	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140787978	140787978	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140787978C>A	ENST00000520790.1	+	1	209	c.209C>A	c.(208-210)gCg>gAg	p.A70E	PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGAGTGAGCGCGGAGAAGCTG	0.567000													22	28					4.72057e-08	5.21756e-08	0.294199	1	0
ITGAD	3681	broad.mit.edu	37	16	31422424	31422424	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:31422424T>A	ENST00000389202.2	+	13	1433	c.1384T>A	c.(1384-1386)Tgc>Agc	p.C462S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	462					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGCCTCCCTCTGCTCTGTGGA	0.662000													210	46					0	0	0.323286	0	0
OR11G2	390439	broad.mit.edu	37	14	20665805	20665805	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20665805T>G	ENST00000357366.3	+	1	311	c.311T>G	c.(310-312)tTc>tGc	p.F104C		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		CTCGCCAACTTCTCCTTCTTG	0.532000													40	165					0	0	0.301197	0	0
ADPRH	141	broad.mit.edu	37	3	119306347	119306347	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:119306347A>C	ENST00000478399.1	+	4	2101	c.696A>C	c.(694-696)aaA>aaC	p.K232N	ADPRH_ENST00000465513.1_Missense_Mutation_p.K232N|ADPRH_ENST00000357003.3_Missense_Mutation_p.K232N|ADPRH_ENST00000471850.1_3'UTR|ADPRH_ENST00000478927.1_Missense_Mutation_p.K232N			P54922	ADPRH_HUMAN	ADP-ribosylarginine hydrolase	232					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			breast(1)|kidney(1)|lung(10)|ovary(1)	13		Lung NSC(201;0.0977)		GBM - Glioblastoma multiforme(114;0.23)		ATTACCTAAAACTTAGAGGGA	0.408000													5	59					0	0	0.217242	0	0
ANKIB1	54467	broad.mit.edu	37	7	91972513	91972513	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:91972513C>A	ENST00000265742.3	+	6	1339	c.963C>A	c.(961-963)atC>atA	p.I321I		NM_019004.1	NP_061877.1	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	321							protein binding|zinc ion binding			cervix(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(19)|skin(1)	41	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CAGATGAAATCAGCTTATCTC	0.438000													31	106					2.08457e-15	2.62116e-15	0.153744	1	0
SEMA5B	54437	broad.mit.edu	37	3	122645495	122645495	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:122645495C>A	ENST00000195173.4	-	9	1183	c.880G>T	c.(880-882)Ggg>Tgg	p.G294W	SEMA5B_ENST00000451055.2_Missense_Mutation_p.G348W|SEMA5B_ENST00000357599.3_Missense_Mutation_p.G294W			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	294	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		GCAAACAGCCCAATATCATAG	0.602000													16	44					1.99824e-07	2.18522e-07	0.160694	1	0
ONECUT2	9480	broad.mit.edu	37	18	55104035	55104035	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:55104035C>T	ENST00000491143.2	+	1	1119	c.1087C>T	c.(1087-1089)Cgg>Tgg	p.R363W		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	363					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		GGTGCTGTGCCGGTCTCAGGG	0.577000													33	25					0	0	0.173368	0	0
CYP1A1	1543	broad.mit.edu	37	15	75013378	75013378	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:75013378T>G	ENST00000379727.3	-	6	1381	c.1183A>C	c.(1183-1185)Agt>Cgt	p.S395R	CYP1A1_ENST00000395048.2_Missense_Mutation_p.S395R|CYP1A1_ENST00000395049.4_Intron|CYP1A1_ENST00000567032.1_Missense_Mutation_p.S395R|CYP1A1_ENST00000564596.1_Missense_Mutation_p.S134R			P04798	CP1A1_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 1	395					cellular lipid metabolic process|drug metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding|vitamin D 24-hydroxylase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(7)|lung(13)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34					Arsenic trioxide(DB01169)|Benzphetamine(DB00865)|Bleomycin(DB00290)|Chlorzoxazone(DB00356)|Dacarbazine(DB00851)|Dactinomycin(DB00970)|Esomeprazole(DB00736)|Estrone(DB00655)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Ginseng(DB01404)|Granisetron(DB00889)|Ketoconazole(DB01026)|Menadione(DB00170)|Picrotoxin(DB00466)|Primaquine(DB01087)|Quinidine(DB00908)|Quinine(DB00468)|Thiabendazole(DB00730)	CCTTTCAAACTTGTGTCTCTT	0.512000									Endometrial Cancer, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				8	81					0	0	0.278610	0	0
TMEM185A	84548	broad.mit.edu	37	X	148690401	148690401	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:148690401C>A	ENST00000316916.8	-	3	640	c.336G>T	c.(334-336)tgG>tgT	p.W112C	TMEM185A_ENST00000507237.1_Missense_Mutation_p.W112C|TMEM185A_ENST00000536359.1_Missense_Mutation_p.W53C	NM_032508.2	NP_115897.1	Q8NFB2	T185A_HUMAN	transmembrane protein 185A	112						integral to membrane		p.W112C(1)		kidney(1)|large_intestine(3)|lung(10)|ovary(1)	15	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					AGACCAGGAGCCAGAAATGGC	0.483000													75	11					4.41824e-40	7.13043e-40	0.323286	1	0
TMEM2	23670	broad.mit.edu	37	9	74345683	74345683	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:74345683C>A	ENST00000377044.4	-	8	2250	c.1711G>T	c.(1711-1713)Ggc>Tgc	p.G571C	TMEM2_ENST00000377066.5_Missense_Mutation_p.G508C	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	571						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		ATAGACAGGCCGTCCACAAAT	0.468000													54	39					2.69953e-25	3.85097e-25	0.323286	1	0
STK11IP	114790	broad.mit.edu	37	2	220473360	220473360	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220473360G>C	ENST00000456909.1	+	15	1749	c.1659G>C	c.(1657-1659)cgG>cgC	p.R553R	STK11IP_ENST00000295641.10_Silent_p.R564R			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	564	Glu-rich.				protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGGCGTACGGGGCAGGGAAT	0.607000													8	12					0	0	0.058154	0	0
RALYL	138046	broad.mit.edu	37	8	85799977	85799977	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:85799977A>T	ENST00000521268.1	+	8	1929	c.824A>T	c.(823-825)gAg>gTg	p.E275V	RALYL_ENST00000522455.1_Missense_Mutation_p.E275V|RALYL_ENST00000518566.1_Missense_Mutation_p.E264V|RALYL_ENST00000521376.1_Intron|RALYL_ENST00000521695.1_Missense_Mutation_p.E275V|RALYL_ENST00000523850.1_Missense_Mutation_p.E202V|RALYL_ENST00000517638.1_Missense_Mutation_p.E288V	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	275							identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						GATGGGATAGAGGAGGACTTC	0.478000													111	150					0	0	0.323286	0	0
STAT5B	6777	broad.mit.edu	37	17	40369475	40369475	+	Missense_Mutation	SNP	T	T	A	rs67333182		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:40369475T>A	ENST00000293328.3	-	10	1345	c.1177A>T	c.(1177-1179)Agt>Tgt	p.S393C		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	393					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	ATCTCGCCACTGTAATCACTG	0.493000													21	40					0	0	0.219247	0	0
INTS4	92105	broad.mit.edu	37	11	77635818	77635818	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:77635818T>C	ENST00000534064.1	-	12	1526	c.1492A>G	c.(1492-1494)Act>Gct	p.T498A	INTS4_ENST00000529807.1_Missense_Mutation_p.T498A|INTS4_ENST00000525931.1_5'UTR	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	498					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			TCCCTATCAGTAGGGTACTTG	0.393000													27	57					0	0	0.144211	0	0
ZFP30	22835	broad.mit.edu	37	19	38126701	38126701	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:38126701A>G	ENST00000351218.2	-	6	1298	c.741T>C	c.(739-741)tgT>tgC	p.C247C	ZFP30_ENST00000514101.2_Silent_p.C247C|ZFP30_ENST00000589018.1_Intron|ZFP30_ENST00000392144.1_Silent_p.C247C	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AGGCTTTCCCACATTCTTTAC	0.403000													62	44					0	0	0.323286	0	0
CYP11B2	1585	broad.mit.edu	37	8	143996514	143996514	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:143996514C>A	ENST00000323110.2	-	3	545	c.543G>T	c.(541-543)cgG>cgT	p.R181R		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	181			R -> W (in CMO-2 deficiency; reduces 18- hydroxylase and abolishes 18-oxidase activities; leaves 11 beta-hydroxylase activity intact; dbSNP:rs28931609).		aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TCAGGCTCCCCCGGGCGTTCT	0.642000									Familial Hyperaldosteronism type I				8	14					9.16793e-09	1.0217e-08	0.160694	1	0
ZFP57	346171	broad.mit.edu	37	6	29643738	29643738	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:29643738C>T	ENST00000376883.1	-	4	573	c.162G>A	c.(160-162)tcG>tcA	p.S54S	ZFP57_ENST00000376881.3_Silent_p.S54S|ZFP57_ENST00000488757.1_Silent_p.S74S			Q9NU63	ZFP57_HUMAN	ZFP57 zinc finger protein	46	KRAB.				DNA methylation involved in embryo development|regulation of gene expression by genetic imprinting|transcription, DNA-dependent		DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(16)|ovary(4)|skin(4)|urinary_tract(5)	44						TAAAGGTTTCCGACATAACAT	0.527000													126	255					0	0	0.323286	0	0
SLC2A2	6514	broad.mit.edu	37	3	170736366	170736366	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:170736366G>T	ENST00000314251.3	-	2	141	c.62C>A	c.(61-63)tCc>tAc	p.S21Y	SLC2A2_ENST00000382808.4_5'UTR	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	21					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			AAACTGGAAGGAACCCAGCAC	0.473000											OREG0015920	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	218	148					1.242e-85	2.24154e-85	0.323286	1	0
CIT	11113	broad.mit.edu	37	12	120214606	120214606	+	Missense_Mutation	SNP	T	T	A	rs149250142	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:120214606T>A	ENST00000392521.2	-	14	1761	c.1706A>T	c.(1705-1707)aAt>aTt	p.N569I	CIT_ENST00000537607.1_5'UTR|CIT_ENST00000261833.7_Missense_Mutation_p.N569I	NM_001206999.1	NP_001193928.1	O14578	CTRO_HUMAN	citron (rho-interacting, serine/threonine kinase 21)	569					intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			breast(6)|endometrium(9)|kidney(4)|large_intestine(15)|liver(1)|lung(29)|ovary(7)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	86	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TTCCAACTGATTCATCATCAA	0.443000													195	325					0	0	0.323286	0	0
PRRC2A	7916	broad.mit.edu	37	6	31600616	31600616	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31600616G>A	ENST00000376033.2	+	16	4400	c.4166G>A	c.(4165-4167)cGg>cAg	p.R1389Q	PRRC2A_ENST00000376007.4_Missense_Mutation_p.R1389Q	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	1389	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						TCAAGTCAGCGGCCAGGCATG	0.637000													102	172					0	0	0.323286	0	0
ENO1	2023	broad.mit.edu	37	1	8926469	8926469	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:8926469C>A	ENST00000234590.4	-	7	655	c.536G>T	c.(535-537)aGg>aTg	p.R179M		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	179	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CATGGCTTCCCTGAAGTTTGC	0.527000													35	63					6.4771e-29	9.57041e-29	0.290176	1	0
COL11A1	1301	broad.mit.edu	37	1	103427757	103427757	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:103427757C>A	ENST00000358392.2	-	40	3442	c.3125G>T	c.(3124-3126)gGg>gTg	p.G1042V	COL11A1_ENST00000370096.3_Missense_Mutation_p.G1030V|COL11A1_ENST00000353414.4_Missense_Mutation_p.G991V|COL11A1_ENST00000512756.1_Missense_Mutation_p.G914V	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1030	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACCTCTTTCCCCTGGGAAACC	0.383000													115	70					2.94363e-73	5.2514e-73	0.323286	1	0
ZC3H10	84872	broad.mit.edu	37	12	56514389	56514389	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:56514389G>T	ENST00000257940.2	+	3	319	c.43G>T	c.(43-45)Ggt>Tgt	p.G15C	RP11-603J24.5_ENST00000550947.1_RNA	NM_032786.1	NP_116175.1	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	15	Gly-rich.						nucleic acid binding|zinc ion binding			breast(1)|endometrium(4)|large_intestine(1)|lung(2)|prostate(2)|skin(1)	11			OV - Ovarian serous cystadenocarcinoma(18;0.12)			CGGGAGCAGCGGTGGAGGCCC	0.612000													7	16					7.93312e-07	8.60556e-07	0.119110	1	0
KIF24	347240	broad.mit.edu	37	9	34310921	34310921	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:34310921G>T	ENST00000379166.2	-	2	543	c.424C>A	c.(424-426)Cca>Aca	p.P142T	KIF24_ENST00000379174.3_Missense_Mutation_p.P142T|KIF24_ENST00000402558.2_Missense_Mutation_p.P142T|KIF24_ENST00000345050.2_Missense_Mutation_p.P142T	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	142					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			GAATCATCTGGTAGCATGTGT	0.403000													223	99					5.20643e-81	9.35827e-81	0.323286	1	0
OR5J2	282775	broad.mit.edu	37	11	55944894	55944894	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55944894T>A	ENST00000312298.1	+	1	801	c.801T>A	c.(799-801)ttT>ttA	p.F267L		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					CCCAGTATTTTGTGGAACAAG	0.443000													48	124					0	0	0.323286	0	0
SP7	121340	broad.mit.edu	37	12	53722395	53722395	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:53722395C>A	ENST00000536324.2	-	3	1114	c.831G>T	c.(829-831)gaG>gaT	p.E277D	SP7_ENST00000303846.3_Missense_Mutation_p.E277D|SP7_ENST00000537210.2_Missense_Mutation_p.E259D	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	277					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						GCCGCTCTAGCTCCTGGCAAT	0.662000													9	16					9.31168e-06	9.94423e-06	0.105934	1	0
CCDC64	92558	broad.mit.edu	37	12	120502555	120502555	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:120502555C>T	ENST00000397558.2	+	4	781	c.781C>T	c.(781-783)Cgg>Tgg	p.R261W	CCDC64_ENST00000446727.2_Missense_Mutation_p.R5W	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	261					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGTCAGATCGGAAACGGGA	0.552000													140	15					0	0	0.323286	0	0
PDGFRB	5159	broad.mit.edu	37	5	149515317	149515317	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:149515317C>A	ENST00000261799.4	-	3	634	c.165G>T	c.(163-165)tcG>tcT	p.S55S		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	55	Ig-like C2-type 1.				aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GAGCTGAACCCGAGCAGGTCA	0.607000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								17	25					3.99206e-14	4.91001e-14	0.189662	1	0
ARHGAP20	57569	broad.mit.edu	37	11	110451883	110451883	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:110451883A>C	ENST00000260283.4	-	16	2071	c.1787T>G	c.(1786-1788)gTt>gGt	p.V596G	ARHGAP20_ENST00000533353.1_Missense_Mutation_p.V570G|ARHGAP20_ENST00000524756.1_Missense_Mutation_p.V573G|ARHGAP20_ENST00000529591.1_Missense_Mutation_p.V139G|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.V560G|ARHGAP20_ENST00000528829.1_Missense_Mutation_p.V560G|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.V570G	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	596					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		TGGTGCATCAACATCCTCATT	0.413000													44	109					0	0	0.323286	0	0
AGBL1	123624	broad.mit.edu	37	15	87097715	87097715	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:87097715A>G	ENST00000441037.2	+	20	2898	c.2803A>G	c.(2803-2805)Aga>Gga	p.R935G	AGBL1_ENST00000389298.3_Missense_Mutation_p.R666G|AGBL1_ENST00000421325.2_Missense_Mutation_p.R935G	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	935					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						GGGGGTGTCCAGAAGCTACAC	0.552000													9	34					0	0	0.105934	0	0
PTPN4	5775	broad.mit.edu	37	2	120709587	120709587	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:120709587A>C	ENST00000263708.2	+	19	2466	c.1695A>C	c.(1693-1695)caA>caC	p.Q565H	PTPN4_ENST00000544261.1_Missense_Mutation_p.Q198H	NM_002830.3	NP_002821.1	P29074	PTN4_HUMAN	protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)	565	PDZ.					cytoplasm|cytoskeleton|internal side of plasma membrane	cytoskeletal protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|urinary_tract(1)	30					Alendronate(DB00630)	AAGGGGACCAAGTTGTACTGA	0.433000													15	119					0	0	0.132662	0	0
MUC12	10071	broad.mit.edu	37	7	100648194	100648194	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100648194A>T	ENST00000379442.3	+	5	14779	c.14779A>T	c.(14779-14781)Agc>Tgc	p.S4927C	MUC12_ENST00000536621.1_Missense_Mutation_p.S4784C			F5GWV9	F5GWV9_HUMAN	mucin 12, cell surface associated	4784										breast(6)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)|stomach(13)	25						GTTCCCTGCCAGCACCACCAC	0.532000													4	9					0	0	0.184627	0	0
VAV3	10451	broad.mit.edu	37	1	108313276	108313276	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:108313276A>G	ENST00000370056.4	-	6	904	c.630T>C	c.(628-630)acT>acC	p.T210T	VAV3_ENST00000343258.4_5'UTR|VAV3_ENST00000527011.1_Silent_p.T210T|VAV3_ENST00000371846.4_Silent_p.T145T	NM_006113.4	NP_006104.4	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor	210	DH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(2)|breast(5)|endometrium(4)|kidney(2)|large_intestine(14)|lung(20)|ovary(6)|prostate(3)|stomach(1)|urinary_tract(1)	58		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TTGACTCCAAAGTTTCTGTAT	0.303000													57	141					0	0	0.323286	0	0
CACNA1C	775	broad.mit.edu	37	12	2656655	2656655	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:2656655A>G	ENST00000335762.5	+	10	1695	c.1430A>G	c.(1429-1431)aAg>aGg	p.K477R	CACNA1C_ENST00000399637.1_Intron|CACNA1C_ENST00000399597.1_Intron|CACNA1C_ENST00000344100.3_Intron|CACNA1C_ENST00000327702.7_Intron|CACNA1C_ENST00000399601.1_Intron|CACNA1C_ENST00000399621.1_Intron|CACNA1C_ENST00000399644.1_Intron|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000399629.1_Intron|CACNA1C_ENST00000399617.1_Intron|CACNA1C_ENST00000399638.1_Intron|CACNA1C_ENST00000402845.3_Intron|CACNA1C_ENST00000406454.3_Intron|CACNA1C_ENST00000399591.1_Intron|CACNA1C_ENST00000399649.1_Intron|CACNA1C_ENST00000399655.1_Intron|CACNA1C_ENST00000399634.1_Intron|CACNA1C_ENST00000480911.1_Intron|CACNA1C_ENST00000347598.4_Intron|CACNA1C_ENST00000491104.1_Intron|CACNA1C_ENST00000399606.1_Intron|CACNA1C_ENST00000399595.1_Intron|CACNA1C_ENST00000399603.1_Intron			Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	463					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AAGAAAGGGAAGTTTGCTTGG	0.498000													17	21					0	0	0.146539	0	0
SPRR3	6707	broad.mit.edu	37	1	152975854	152975854	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152975854C>A	ENST00000331860.3	+	3	508	c.358C>A	c.(358-360)Caa>Aaa	p.Q120K	SPRR3_ENST00000542696.1_Missense_Mutation_p.Q112K|SPRR3_ENST00000295367.4_Missense_Mutation_p.Q120K	NM_005416.2	NP_005407.1	Q9UBC9	SPRR3_HUMAN	small proline-rich protein 3	120	14 X 8 AA approximate tandem repeats.				keratinization|peptide cross-linking|wound healing	cytoplasm	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	11	Lung NSC(65;1.49e-28)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGTCCCTGACCAAGGCTTCAT	0.552000													80	170					2.05912e-35	3.22239e-35	0.323286	1	0
AGTR1	185	broad.mit.edu	37	3	148459428	148459428	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:148459428G>T	ENST00000542281.1	+	4	1052	c.606G>T	c.(604-606)ctG>ctT	p.L202L	AGTR1_ENST00000349243.3_Silent_p.L202L|AGTR1_ENST00000418473.2_Silent_p.L202L|AGTR1_ENST00000475347.1_Silent_p.L202L|AGTR1_ENST00000474935.1_Silent_p.L202L|AGTR1_ENST00000497524.1_Silent_p.L202L|AGTR1_ENST00000461609.1_Silent_p.L202L|AGTR1_ENST00000402260.1_Silent_p.L202L|AGTR1_ENST00000404754.2_Silent_p.L202L	NM_031850.3	NP_114038.4	P30556	AGTR1_HUMAN	angiotensin II receptor, type 1	202					calcium-mediated signaling|cell chemotaxis|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|kidney development|low-density lipoprotein particle remodeling|positive regulation of cellular protein metabolic process|positive regulation of cholesterol esterification|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of phospholipase A2 activity|positive regulation of reactive oxygen species metabolic process|regulation of cell growth|regulation of cell proliferation|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|Rho protein signal transduction		acetyltransferase activator activity|angiotensin type I receptor activity|angiotensin type II receptor activity|bradykinin receptor binding|protein heterodimerization activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30			LUSC - Lung squamous cell carcinoma(72;0.127)|Lung(72;0.152)		Candesartan(DB00796)|Eprosartan(DB00876)|Forasartan(DB01342)|Irbesartan(DB01029)|Losartan(DB00678)|Olmesartan(DB00275)|Saprisartan(DB01347)|Spironolactone(DB00421)|Tasosartan(DB01349)|Telmisartan(DB00966)|Valsartan(DB00177)	AAAATATACTGGGTTTCCTGT	0.373000													27	67					2.12542e-12	2.53951e-12	0.116897	1	0
MAGEC3	139081	broad.mit.edu	37	X	140983193	140983193	+	Translation_Start_Site	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:140983193G>A	ENST00000544766.1	+	0	288				MAGEC3_ENST00000536088.1_Intron|MAGEC3_ENST00000483584.1_3'UTR|MAGEC3_ENST00000448920.1_Missense_Mutation_p.G102S|MAGEC3_ENST00000443323.2_Intron|MAGEC3_ENST00000298296.1_Splice_Site_p.G350_splice	NM_177456.2	NP_803251.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3											NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					CAATCCTCAAGGTAAGGGCCC	0.577000													72	9					0	0	0.323286	0	0
DNAJC13	23317	broad.mit.edu	37	3	132172986	132172986	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:132172986A>T	ENST00000260818.6	+	9	1165	c.917A>T	c.(916-918)tAt>tTt	p.Y306F	DNAJC13_ENST00000486798.1_3'UTR	NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	306							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						GTACGGAAATATTCTTCAACA	0.323000													35	68					0	0	0.235728	0	0
C7orf66	154907	broad.mit.edu	37	7	108524516	108524516	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:108524516C>A	ENST00000379007.2	-	1	128	c.74G>T	c.(73-75)tGg>tTg	p.W25L		NM_001024607.1	NP_001019778.1	A4D0T2	CG066_HUMAN	chromosome 7 open reading frame 66	25						integral to membrane				breast(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)	15						ACTGAGGCTCCAAAGTCTCTG	0.383000													63	191					5.21738e-30	7.79085e-30	0.323286	1	0
CADM3	57863	broad.mit.edu	37	1	159161833	159161833	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:159161833G>T	ENST00000368125.4	+	2	353	c.196G>T	c.(196-198)Gct>Tct	p.A66S	CADM3_ENST00000368124.4_Missense_Mutation_p.A100S	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	66	Ig-like V-type.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					GTCTAACCCTGCTCAGCAGAC	0.522000													86	63					1.26458e-31	1.92169e-31	0.323286	1	0
UBAP2L	9898	broad.mit.edu	37	1	154207765	154207765	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:154207765G>T	ENST00000428931.1	+	6	709	c.542G>T	c.(541-543)aGa>aTa	p.R181I	UBAP2L_ENST00000271877.7_Missense_Mutation_p.R192I|UBAP2L_ENST00000343815.6_Missense_Mutation_p.R181I|UBAP2L_ENST00000361546.2_Missense_Mutation_p.R181I	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	181					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGCCGAGGCAGAGGTGATCAG	0.468000													9	18					7.48243e-07	8.1252e-07	0.058154	1	0
NRIP1	8204	broad.mit.edu	37	21	16340033	16340033	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:16340033C>T	ENST00000400202.1	-	3	1193	c.481G>A	c.(481-483)Gga>Aga	p.G161R	NRIP1_ENST00000400199.1_Missense_Mutation_p.G161R|NRIP1_ENST00000318948.4_Missense_Mutation_p.G161R			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	161	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		AGGGCATATCCTTGCTCCTTG	0.423000													101	9					0	0	0.323286	0	0
OR9I1	219954	broad.mit.edu	37	11	57886033	57886033	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:57886033T>G	ENST00000302610.1	-	1	883	c.884A>C	c.(883-885)aAa>aCa	p.K295T	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	295					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				TTTTACATCTTTGTTTCTTAA	0.448000													46	349					0	0	0.323286	0	0
OOSP2	219990	broad.mit.edu	37	11	59812175	59812175	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:59812175C>A	ENST00000278855.2	+	3	460	c.275C>A	c.(274-276)aCc>aAc	p.T92N	PLAC1L_ENST00000532905.1_Missense_Mutation_p.T61N	NM_173801.3	NP_776162.2	Q86WS3	PLACL_HUMAN		92						extracellular region				breast(1)|lung(9)|ovary(2)|prostate(2)|skin(1)	15						CTTTTTCAAACCGAGCTGTAC	0.418000													26	73					6.12954e-19	8.06422e-19	0.309145	1	0
PRPS2	5634	broad.mit.edu	37	X	12817486	12817486	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:12817486G>T	ENST00000380668.5	+	2	411	c.283G>T	c.(283-285)Gcc>Tcc	p.A95S	PRPS2_ENST00000398491.2_Missense_Mutation_p.A95S|PRPS2_ENST00000489404.1_Missense_Mutation_p.A95S	NM_001039091.2|NM_002765.4	NP_001034180.1|NP_002756.1	P11908	PRPS2_HUMAN	phosphoribosyl pyrophosphate synthetase 2	95					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	16						TTTCCCATACGCCCGACAAGA	0.468000													222	15					8.38915e-122	1.54742e-121	0.323286	1	0
GAP43	2596	broad.mit.edu	37	3	115395142	115395142	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:115395142G>T	ENST00000393780.3	+	3	889	c.421G>T	c.(421-423)Gga>Tga	p.G141*	GAP43_ENST00000305124.6_Nonsense_Mutation_p.G105*	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	105					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		CGGCAAAGCAGGAGAAACTCC	0.637000													11	43					6.49762e-13	7.81784e-13	0.175082	1	0
PCDH20	64881	broad.mit.edu	37	13	61987879	61987879	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:61987879G>T	ENST00000409186.1	-	5	2458	c.353C>A	c.(352-354)tCc>tAc	p.S118Y	PCDH20_ENST00000409204.4_Missense_Mutation_p.S118Y			Q8N6Y1	PCD20_HUMAN	protocadherin 20	91	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CAGGCTGAAGGAGAGAGGGGG	0.682000													13	22					7.45023e-12	8.82346e-12	0.219247	1	0
TMEM2	23670	broad.mit.edu	37	9	74365095	74365095	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:74365095T>C	ENST00000377044.4	-	2	734	c.195A>G	c.(193-195)gaA>gaG	p.E65E	TMEM2_ENST00000377066.5_Silent_p.E65E	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	65						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		CTTGCTGTTCTTCAGGTGAGA	0.428000													20	43					0	0	0.249174	0	0
DNMT3L	29947	broad.mit.edu	37	21	45671573	45671573	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:45671573C>A	ENST00000270172.3	-	9	1185	c.702G>T	c.(700-702)gaG>gaT	p.E234D	DNMT3L_ENST00000418993.1_Missense_Mutation_p.E234D	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	234					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		AGGGTCCCCACTCCTCCACCT	0.652000													6	12					0.0293803	0.0298723	0.248553	1	0
FAM71B	153745	broad.mit.edu	37	5	156589529	156589529	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:156589529G>T	ENST00000302938.4	-	2	1842	c.1747C>A	c.(1747-1749)Ctg>Atg	p.L583M		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	583						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATCATCTCCAGCTCCTGGCCA	0.507000													111	147					7.18566e-60	1.258e-59	0.323286	1	0
PRELP	5549	broad.mit.edu	37	1	203453258	203453258	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:203453258C>A	ENST00000343110.2	+	2	1073	c.946C>A	c.(946-948)Ctg>Atg	p.L316M		NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein	316					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCTGGAACACCTGTACCTCAA	0.567000													29	84					1.07637e-12	1.29256e-12	0.214465	1	0
UMODL1	89766	broad.mit.edu	37	21	43529799	43529799	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:43529799G>C	ENST00000400427.1	+	10	1827	c.1431G>C	c.(1429-1431)cgG>cgC	p.R477R	UMODL1_ENST00000408989.2_Silent_p.R549R|UMODL1_ENST00000408910.2_Silent_p.R549R|UMODL1_ENST00000400424.1_Silent_p.R477R	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	549	SEA 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						GCGCAGGCCGGGCCTGTGAGG	0.672000													6	4					0	0	0.307466	0	0
CMKLR1	1240	broad.mit.edu	37	12	108686013	108686013	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:108686013T>C	ENST00000397688.2	-	3	1090	c.721A>G	c.(721-723)Atc>Gtc	p.I241V	CMKLR1_ENST00000550402.1_Missense_Mutation_p.I243V|CMKLR1_ENST00000412676.1_Missense_Mutation_p.I243V|CMKLR1_ENST00000312143.7_Missense_Mutation_p.I243V|CMKLR1_ENST00000552995.1_Missense_Mutation_p.I241V	NM_004072.2	NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	243					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						TTGCACACGATGGTGAGGTAG	0.557000													51	5					0	0	0.323286	0	0
MAST3	23031	broad.mit.edu	37	19	18254702	18254702	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:18254702G>T	ENST00000262811.5	+	21	2382	c.2382G>T	c.(2380-2382)gaG>gaT	p.E794D		NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	794							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						TCTCATCAGAGGATGAGGGGG	0.632000													16	8					1.99824e-07	2.18522e-07	0.160694	1	0
NBEAP1	606	broad.mit.edu	37	15	20876598	20876598	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:20876598C>A	ENST00000556948.1	-	0	2																											CTCTTGATGACTAAGAAAGAA	0.318000													17	130					4.35082e-09	4.87499e-09	0.219247	1	0
ALK	238	broad.mit.edu	37	2	29551311	29551311	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:29551311G>C	ENST00000389048.3	-	6	2225	c.1319C>G	c.(1318-1320)tCc>tGc	p.S440C	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	440	LDL-receptor class A.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	ACAAGTGAAGGAGCTCTGCAG	0.587000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				38	58					0	0	0.279185	0	0
FOSL1	8061	broad.mit.edu	37	11	65664377	65664377	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:65664377G>T	ENST00000312562.2	-	2	386	c.200C>A	c.(199-201)cCt>cAt	p.P67H	FOSL1_ENST00000532401.1_Missense_Mutation_p.P67H|FOSL1_ENST00000531493.1_Missense_Mutation_p.P67H|FOSL1_ENST00000448083.2_Intron	NM_005438.3	NP_005429.1	P15407	FOSL1_HUMAN	FOS-like antigen 1	67					cellular defense response|chemotaxis|positive regulation of cell proliferation|response to virus|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	10				READ - Rectum adenocarcinoma(159;0.168)		GTAGGTCAGAGGCCTGGGGTA	0.622000													19	32					1.01871e-10	1.17942e-10	0.204396	1	0
SP140	11262	broad.mit.edu	37	2	231134613	231134613	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:231134613G>T	ENST00000392045.3	+	14	1503	c.1389G>T	c.(1387-1389)gaG>gaT	p.E463D	SP140_ENST00000417495.3_Missense_Mutation_p.E349D|SP140_ENST00000420434.3_Missense_Mutation_p.E436D|SP140_ENST00000343805.6_Missense_Mutation_p.E403D|SP140_ENST00000350136.5_Missense_Mutation_p.E332D|SP140_ENST00000486687.2_Missense_Mutation_p.E387D	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	463					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TCTCAGAAGAGGTGCCAGGAA	0.517000													24	158					3.28513e-13	3.97423e-13	0.294199	1	0
RNF213	57674	broad.mit.edu	37	17	78268749	78268749	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:78268749A>G	ENST00000582970.1	+	9	1845	c.1702A>G	c.(1702-1704)Att>Gtt	p.I568V	RNF213_ENST00000508628.2_Missense_Mutation_p.I617V|RNF213_ENST00000456466.1_Missense_Mutation_p.I568V|RNF213_ENST00000319921.4_Missense_Mutation_p.I568V	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	568										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ACAGCCTATGATTTATGAAGG	0.537000													29	61					0	0	0.183431	0	0
B3GALT2	8707	broad.mit.edu	37	1	193150639	193150639	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:193150639G>T	ENST00000367434.4	-	2	809	c.54C>A	c.(52-54)gcC>gcA	p.A18A	CDC73_ENST00000367435.3_Intron	NM_003783.3	NP_003774.1	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2	18					protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)	16						GAGACCTTTTGGCATTCCAGG	0.408000													25	127					2.70662e-09	3.04926e-09	0.144211	1	0
EPHA6	285220	broad.mit.edu	37	3	96706580	96706580	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:96706580G>C	ENST00000389672.5	+	3	895	c.857G>C	c.(856-858)gGg>gCg	p.G286A	EPHA6_ENST00000470610.2_Missense_Mutation_p.G286A|EPHA6_ENST00000542517.1_Missense_Mutation_p.G192A	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	191						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CAAGACATTGGGGCGTGCATT	0.458000													212	490					0	0	0.323286	0	0
ACY3	91703	broad.mit.edu	37	11	67410235	67410235	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:67410235G>A	ENST00000255082.3	-	8	1090	c.920C>T	c.(919-921)gCc>gTc	p.A307V	ACY3_ENST00000529256.1_Missense_Mutation_p.A186V	NM_080658.1	NP_542389.1	Q96HD9	ACY3_HUMAN	aspartoacylase (aminocyclase) 3	307					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding			endometrium(1)|lung(5)|prostate(2)	8					L-Aspartic Acid(DB00128)	CGCGGGCATGGCAGGCACGGT	0.587000													10	17					0	0	0.105934	0	0
SPATA7	55812	broad.mit.edu	37	14	88883135	88883135	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:88883135A>G	ENST00000556553.1	+	5	782	c.223A>G	c.(223-225)Atg>Gtg	p.M75V	SPATA7_ENST00000356583.5_Missense_Mutation_p.M75V|SPATA7_ENST00000393545.4_Missense_Mutation_p.M107V|SPATA7_ENST00000045347.7_Missense_Mutation_p.M107V			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	107					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						TAAAACTGCAATGCGAGCCAA	0.289000													9	127					0	0	0.058154	0	0
COL12A1	1303	broad.mit.edu	37	6	75798880	75798880	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:75798880T>A	ENST00000322507.8	-	64	9261	c.8952A>T	c.(8950-8952)ggA>ggT	p.G2984G	COL12A1_ENST00000483888.2_Silent_p.G2980G|COL12A1_ENST00000416123.2_Silent_p.G2908G|COL12A1_ENST00000511023.1_5'UTR|COL12A1_ENST00000345356.6_Silent_p.G1820G	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2984	Triple-helical region (COL1) with 2 imperfections.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CACCTTTCTCTCCTGGCAAAC	0.423000													21	62					0	0	0.264190	0	0
KIF3B	9371	broad.mit.edu	37	20	30898858	30898858	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:30898858G>T	ENST00000375712.3	+	2	1445	c.1278G>T	c.(1276-1278)cgG>cgT	p.R426R	KIF3B_ENST00000418717.2_Intron	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	426					anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TTGAGAAGCGGGCCATTGTAG	0.532000													34	32					1.30998e-17	1.69254e-17	0.225048	1	0
PITPNM3	83394	broad.mit.edu	37	17	6367111	6367111	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:6367111G>A	ENST00000262483.8	-	17	2334	c.2247C>T	c.(2245-2247)gcC>gcT	p.A749A	ACKR6_ENST00000421306.3_Silent_p.A713A|ACKR6_ENST00000576664.1_5'UTR	NM_031220.3	NP_112497.2																					TAGACACGCTGGCCGCGAAGG	0.607000													7	16					0	0	0.093190	0	0
DSPP	1834	broad.mit.edu	37	4	88534363	88534363	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:88534363A>G	ENST00000399271.1	+	4	1145	c.1025A>G	c.(1024-1026)gAg>gGg	p.E342G	RP11-742B18.1_ENST00000506480.1_RNA|DSPP_ENST00000282478.7_Missense_Mutation_p.E342G	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	342					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		CAAAGAATAGAGGACACCCAG	0.443000													4	39					0	0	0.150653	0	0
LTBP2	4053	broad.mit.edu	37	14	74969991	74969991	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:74969991T>G	ENST00000261978.4	-	33	5205	c.4819A>C	c.(4819-4821)Acg>Ccg	p.T1607P	LTBP2_ENST00000556690.1_Missense_Mutation_p.T1563P	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1607	TB 4.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CAGCATTCCGTGTAGGTGGTG	0.617000													17	45					0	0	0.189662	0	0
SEMA3D	223117	broad.mit.edu	37	7	84636208	84636208	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:84636208A>G	ENST00000284136.6	-	16	1861	c.1818T>C	c.(1816-1818)ttT>ttC	p.F606F	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	606	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AGGTTGAGTTAAATTCAATGC	0.383000													51	222					0	0	0.323286	0	0
SLC39A12	221074	broad.mit.edu	37	10	18242350	18242350	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:18242350G>A	ENST00000377369.2	+	2	418	c.145G>A	c.(145-147)Gtt>Att	p.V49I	SLC39A12_ENST00000377371.3_Missense_Mutation_p.V49I|SLC39A12_ENST00000539911.1_Intron|SLC39A12_ENST00000377374.4_Missense_Mutation_p.V49I	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	49					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						CCTGCTACAGGTTCTCTCTGC	0.532000													10	149					0	0	0.093190	0	0
CACNA1D	776	broad.mit.edu	37	3	53809960	53809960	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:53809960C>G	ENST00000288139.3	+	36	4428	c.4310C>G	c.(4309-4311)cCa>cGa	p.P1437R	CACNA1D_ENST00000540742.1_Missense_Mutation_p.P309R|CACNA1D_ENST00000422281.2_Missense_Mutation_p.P1402R|CACNA1D_ENST00000350061.5_Missense_Mutation_p.P1417R	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1417	Dihydropyridine binding (By similarity).|Phenylalkylamine binding (By similarity).				axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GCCTGTCTCCCAGGGAAGCTC	0.488000													20	212					0	0	0.264190	0	0
GOLGA5	9950	broad.mit.edu	37	14	93305735	93305735	+	Nonstop_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:93305735A>G	ENST00000355976.2	+	12	2258	c.2076A>G	c.(2074-2076)tgA>tgG	p.*692W	GOLGA5_ENST00000163416.2_Missense_Mutation_p.I714V			Q8TBA6	GOGA5_HUMAN	golgin A5	0					Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			large_intestine(6)|lung(1)|ovary(2)	9		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		CTGGGTCATGATTGTTCTGTT	0.428000			T	RET	papillary thyroid								33	118					0	0	0.193644	0	0
TTLL6	284076	broad.mit.edu	37	17	46847394	46847394	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:46847394C>T	ENST00000393382.3	-	14	2247	c.2106G>A	c.(2104-2106)ccG>ccA	p.P702P	TTLL6_ENST00000433608.2_Silent_p.P395P	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	654						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CCAGGGTTGGCGGAGACTTTG	0.522000													25	51					0	0	0.144211	0	0
MMP20	9313	broad.mit.edu	37	11	102482543	102482543	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:102482543T>C	ENST00000260228.2	-	3	478	c.466A>G	c.(466-468)Agc>Ggc	p.S156G	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	156					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		CTGACAAAGCTCAGAGGGACG	0.433000													4	54					0	0	0.184627	0	0
ZBED2	79413	broad.mit.edu	37	3	111312893	111312893	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:111312893G>T	ENST00000317012.4	-	2	1164	c.156C>A	c.(154-156)acC>acA	p.T52T	CD96_ENST00000352690.4_Intron|CD96_ENST00000438817.2_Intron|CD96_ENST00000283285.5_Intron	NM_024508.4	NP_078784.2	Q9BTP6	ZBED2_HUMAN	zinc finger, BED-type containing 2	52							DNA binding|metal ion binding			large_intestine(3)|lung(1)|skin(2)	6						CAGAGAACCGGGTGCCCTTGT	0.557000													49	32					5.13769e-22	7.05919e-22	0.323286	1	0
CSPG4	1464	broad.mit.edu	37	15	75983079	75983079	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:75983079G>A	ENST00000308508.5	-	3	419	c.327C>T	c.(325-327)ccC>ccT	p.P109P		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	109	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						CCACAGTGTGGGGGATGGAGT	0.607000													21	14					0	0	0.219247	0	0
PRLHR	2834	broad.mit.edu	37	10	120354228	120354228	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:120354228C>G	ENST00000239032.2	-	2	667	c.529G>C	c.(529-531)Gcc>Ccc	p.A177P	PRLHR_ENST00000369169.1_Missense_Mutation_p.A177P	NM_004248.2	NP_004239.1	P49683	PRLHR_HUMAN	prolactin releasing hormone receptor	177					female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity			large_intestine(2)|lung(8)|ovary(1)|skin(1)	12		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		ACAGCGTAGGCGCTGAGGCGC	0.687000													4	4					0	0	0.217242	0	0
PAX3	5077	broad.mit.edu	37	2	223084955	223084955	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:223084955G>T	ENST00000350526.4	-	7	1213	c.1077C>A	c.(1075-1077)acC>acA	p.T359T	PAX3_ENST00000344493.4_Silent_p.T359T|PAX3_ENST00000392070.2_Silent_p.T359T|PAX3_ENST00000392069.2_Silent_p.T359T|PAX3_ENST00000464706.1_5'UTR|PAX3_ENST00000336840.6_Silent_p.T359T|PAX3_ENST00000409551.3_Silent_p.T358T	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	359					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATCCATGCCTGGTGCTGGGGA	0.577000			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						34	100					2.20474e-14	2.73013e-14	0.193644	1	0
SEMA3F	6405	broad.mit.edu	37	3	50223738	50223738	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:50223738G>T	ENST00000002829.3	+	17	2254	c.1770G>T	c.(1768-1770)cgG>cgT	p.R590R	SEMA3F_ENST00000413852.1_Silent_p.R491R|SEMA3F_ENST00000434342.1_Silent_p.R559R	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	590					axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		AGGACGTCCGGCACGGAAACC	0.637000													4	11					0.00116845	0.00120784	0.217242	1	0
TRAV23DV6	28660	broad.mit.edu	37	14	22554927	22554927	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:22554927G>T	ENST00000390451.2	+	0	98																											CTCTAAGCAGGGGTGAGTGGC	0.393000													36	79					2.95478e-19	3.90899e-19	0.268233	1	0
FRAS1	80144	broad.mit.edu	37	4	79308821	79308821	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:79308821A>G	ENST00000264895.6	+	29	4381	c.3941A>G	c.(3940-3942)cAt>cGt	p.H1314R	FRAS1_ENST00000325942.6_Missense_Mutation_p.H1314R	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	1313					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CACTCCTTCCATAATATACTG	0.453000													6	32					0	0	0.307466	0	0
FOXD4	2298	broad.mit.edu	37	9	116941	116941	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:116941C>T	ENST00000382500.2	-	1	1476	c.1179G>A	c.(1177-1179)tcG>tcA	p.S393S		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	393					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GCAGCAGCGCCGACGCGGCCG	0.667000													7	73					0	0	0.175082	0	0
ARAP1	116985	broad.mit.edu	37	11	72418409	72418409	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:72418409C>G	ENST00000359373.5	-	12	2385	c.1534G>C	c.(1534-1536)Gac>Cac	p.D512H	ARAP1_ENST00000393605.3_Missense_Mutation_p.D272H|ARAP1_ENST00000455638.2_Missense_Mutation_p.D512H|ARAP1_ENST00000429686.1_Missense_Mutation_p.D267H|ARAP1_ENST00000393609.3_Missense_Mutation_p.D512H|ARAP1_ENST00000334211.8_Missense_Mutation_p.D267H|ARAP1_ENST00000426523.1_Missense_Mutation_p.D267H			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	512	PH 2.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						AGCTCTGAGTCAGCAGAGAAG	0.602000													5	31					0	0	0.217242	0	0
ABCF1	23	broad.mit.edu	37	6	30553991	30553991	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:30553991C>T	ENST00000326195.8	+	18	1906	c.1794C>T	c.(1792-1794)gcC>gcT	p.A598A	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Silent_p.A560A	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	598					inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						CCCAGGAGGCCCCTGAGCTCC	0.557000													78	184					0	0	0.323286	0	0
SPHKAP	80309	broad.mit.edu	37	2	228855716	228855716	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:228855716C>A	ENST00000392056.3	-	11	5005	c.4959_splice	c.e11+1	p.K1653_splice	SPHKAP_ENST00000344657.5_Splice_Site_p.K1624_splice	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1653						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TACATGATACCTTTTCAATTC	0.428000													24	97					4.26978e-12	5.07036e-12	0.279207	1	0
SLC25A39	51629	broad.mit.edu	37	17	42398532	42398532	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:42398532C>A	ENST00000225308.8	-	8	735	c.561G>T	c.(559-561)tcG>tcT	p.S187S	SLC25A39_ENST00000537904.2_Silent_p.S172S|SLC25A39_ENST00000377095.5_Silent_p.S195S|SLC25A39_ENST00000586016.1_Silent_p.S63S|SLC25A39_ENST00000590194.1_Silent_p.S187S	NM_016016.2	NP_057100.1	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39	195					heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				endometrium(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	7		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		GCTCCCGGTACGACACATGCT	0.632000													6	10					0.000157383	0.000164723	0.278610	1	0
PML	5371	broad.mit.edu	37	15	74290568	74290568	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:74290568T>A	ENST00000565898.1	+	2	437	c.353T>A	c.(352-354)gTg>gAg	p.V118E	PML_ENST00000359928.4_Missense_Mutation_p.V118E|PML_ENST00000395135.3_Missense_Mutation_p.V118E|PML_ENST00000354026.6_Missense_Mutation_p.V118E|PML_ENST00000569965.1_Missense_Mutation_p.V118E|PML_ENST00000564428.1_Missense_Mutation_p.V118E|PML_ENST00000567543.1_Missense_Mutation_p.V118E|PML_ENST00000569477.1_Missense_Mutation_p.V118E|PML_ENST00000268058.3_Missense_Mutation_p.V118E|PML_ENST00000435786.2_Missense_Mutation_p.V118E|PML_ENST00000563500.1_Missense_Mutation_p.V118E|PML_ENST00000436891.3_Missense_Mutation_p.V118E|PML_ENST00000268059.6_Missense_Mutation_p.V118E|PML_ENST00000395132.2_Missense_Mutation_p.V118E			P29590	PML_HUMAN	promyelocytic leukemia	118					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						CGCCTGTCGGTGTACCGGCAG	0.637000			T	"""RARA, PAX5"""	"""APL, ALL"""								6	33					0	0	0.080935	0	0
SLC52A3	113278	broad.mit.edu	37	20	746024	746024	+	Missense_Mutation	SNP	C	C	T	rs142157418		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:746024C>T	ENST00000381944.3	-	2	636	c.395G>A	c.(394-396)cGg>cAg	p.R132Q	SLC52A3_ENST00000473664.1_5'UTR|SLC52A3_ENST00000217254.7_Missense_Mutation_p.R132Q			Q9NQ40	RFT2_HUMAN	solute carrier family 52 (riboflavin transporter), member 3	132			R -> W (in BVVLS).		sensory perception of sound	integral to plasma membrane	riboflavin transporter activity										GGTGGGCAGCCGGCTCATGAA	0.627000													21	24					0	0	0.294199	0	0
GLIS3	169792	broad.mit.edu	37	9	3937124	3937124	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:3937124T>A	ENST00000324333.10	-	4	1504	c.1311A>T	c.(1309-1311)acA>acT	p.T437T	GLIS3_ENST00000381971.3_Silent_p.T592T|GLIS3_ENST00000461870.1_5'UTR	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	437					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCTTCTCGCCTGTGTGGCTCC	0.502000													137	211					0	0	0.323286	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39086799	39086799	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:39086799C>A	ENST00000297668.6	-	20	3341	c.3268G>T	c.(3268-3270)Gca>Tca	p.A1090S	CNTNAP3_ENST00000377656.2_Missense_Mutation_p.A1009S|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.A1002S	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	1090	Laminin G-like 4.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		AAGGTAAATGCATCAGGATTT	0.333000													44	14					6.7651e-33	1.04081e-32	0.323286	1	0
MOB3B	79817	broad.mit.edu	37	9	27455253	27455253	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:27455253C>A	ENST00000262244.5	-	2	720	c.296G>T	c.(295-297)cGg>cTg	p.R99L		NM_024761.4	NP_079037.3	Q86TA1	MOL2B_HUMAN	MOB kinase activator 3B	99							metal ion binding|protein binding										ATCCTGCCACCGATACTCATA	0.502000													44	181					2.2129e-31	3.35127e-31	0.323286	1	0
TLL1	7092	broad.mit.edu	37	4	166910616	166910616	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:166910616C>A	ENST00000061240.2	+	2	900	c.253C>A	c.(253-255)Ccc>Acc	p.P85T	TLL1_ENST00000513213.1_Missense_Mutation_p.P85T|TLL1_ENST00000507499.1_Missense_Mutation_p.P85T	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	85					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		TACGCAGAACCCCTTTGGAAA	0.323000													50	9					4.33383e-22	5.96793e-22	0.323286	1	0
PCDH17	27253	broad.mit.edu	37	13	58207777	58207777	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:58207777C>T	ENST00000377918.3	+	1	1123	c.1097C>T	c.(1096-1098)cCt>cTt	p.P366L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	366	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GAGGCCGCCCCTCCCGGCACC	0.687000													12	16					0	0	0.119110	0	0
RNF217-AS1	7955	broad.mit.edu	37	6	125232238	125232238	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:125232238C>A	ENST00000439075.1	-	0	2507					NR_026876.1																						TAGCATAACCCAGGAAGTGAC	0.333000													10	45					0.000442599	0.000461525	0.058154	1	0
ASTN1	460	broad.mit.edu	37	1	176983956	176983956	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:176983956G>T	ENST00000367654.2	-	8	1531	c.1518C>A	c.(1516-1518)tgC>tgA	p.C506*	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Nonsense_Mutation_p.C498*|ASTN1_ENST00000361833.2_Nonsense_Mutation_p.C498*|ASTN1_ENST00000367657.3_Nonsense_Mutation_p.C498*			O14525	ASTN1_HUMAN	astrotactin 1	506	EGF-like 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						CGTTCCGAATGCAAAGGTGCT	0.483000													377	989					1.21689e-121	2.24328e-121	0.323286	1	0
SLIT2	9353	broad.mit.edu	37	4	20611666	20611666	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:20611666C>A	ENST00000504154.1	+	34	3975	c.3723C>A	c.(3721-3723)caC>caA	p.H1241Q	SLIT2_ENST00000273739.5_Missense_Mutation_p.H1254Q|SLIT2_ENST00000503823.1_Missense_Mutation_p.H1233Q|SLIT2_ENST00000503837.1_Missense_Mutation_p.H1237Q	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1241	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						GAAACTTCCACATTGTGGAAC	0.388000													14	43					6.97489e-18	9.03439e-18	0.214465	1	0
TRIM51	84767	broad.mit.edu	37	11	55657435	55657435	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55657435T>A	ENST00000449290.2	+	6	871	c.779T>A	c.(778-780)cTg>cAg	p.L260Q	TRIM51_ENST00000244891.3_Missense_Mutation_p.L117Q	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	260						intracellular	zinc ion binding										TCTCTGCTGCTGCAAGTGTCT	0.468000													19	82					0	0	0.153744	0	0
KCNH7	90134	broad.mit.edu	37	2	163241388	163241388	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:163241388C>T	ENST00000332142.5	-	13	2871	c.2772G>A	c.(2770-2772)aaG>aaA	p.K924K		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	924					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	CAAAGTGTCTCTTGGAACTCT	0.363000													28	253					0	0	0.134883	0	0
SPDYE3	441272	broad.mit.edu	37	7	99905561	99905561	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:99905561C>A	ENST00000332397.6	+	1	237	c.53C>A	c.(52-54)aCc>aAc	p.T18N	SPDYE3_ENST00000437326.2_5'UTR	NM_001004351.4	NP_001004351.3	A6NKU9	SPDE3_HUMAN	speedy/RINGO cell cycle regulator family member E3	18										endometrium(10)|kidney(1)|lung(8)|urinary_tract(1)	20						CAGCGGAGCACCTCAGGGTAC	0.562000													3	15					0.004672	0.00479271	0.115264	1	0
LRRC66	339977	broad.mit.edu	37	4	52861921	52861921	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:52861921C>A	ENST00000343457.3	-	4	1273	c.1267G>T	c.(1267-1269)Gag>Tag	p.E423*		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	423						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						TAGAAGCCCTCGTTTGAATAC	0.542000													254	247					1.57988e-172	2.93339e-172	0.323286	1	0
KRT72	140807	broad.mit.edu	37	12	52986695	52986695	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:52986695T>G	ENST00000293745.2	-	3	768	c.683A>C	c.(682-684)gAg>gCg	p.E228A	KRT72_ENST00000398066.3_Missense_Mutation_p.E40A|KRT72_ENST00000354310.4_Missense_Mutation_p.E228A|KRT72_ENST00000537672.2_Missense_Mutation_p.E228A	NM_080747.2	NP_542785.1	Q14CN4	K2C72_HUMAN	keratin 72	228	Coil 1B.|Rod.					keratin filament	structural molecule activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(357;0.195)		CACCACAAACTCATTCTCAGC	0.507000													34	118					0	0	0.312237	0	0
MIR518D	574489	broad.mit.edu	37	19	54238161	54238161	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:54238161C>A	ENST00000385014.1	+	0	31					NR_030211.1																						GAGGGAAGCACTTTCTGTTGT	0.423000													129	8					5.78353e-53	9.87409e-53	0.323286	1	0
CWF19L2	143884	broad.mit.edu	37	11	107288935	107288935	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:107288935C>A	ENST00000282251.5	-	9	1539	c.1512G>T	c.(1510-1512)gaG>gaT	p.E504D	CWF19L2_ENST00000433523.1_Missense_Mutation_p.E504D	NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)	504							catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		TCCCCATCATCTCTGCTTTGA	0.368000													36	138					3.76114e-14	4.63704e-14	0.203993	1	0
CDH22	64405	broad.mit.edu	37	20	44815306	44815306	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:44815306G>T	ENST00000372262.3	-	9	1984	c.1584C>A	c.(1582-1584)ccC>ccA	p.P528P	CDH22_ENST00000537909.1_Silent_p.P528P	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	528	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GCCCGCCTTGGGGCTCGTCTC	0.587000													66	95					5.5301e-39	8.86935e-39	0.323286	1	0
ZNF804A	91752	broad.mit.edu	37	2	185802931	185802931	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:185802931C>A	ENST00000302277.6	+	4	3402	c.2808C>A	c.(2806-2808)caC>caA	p.H936Q		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	936						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGCTTGAACACAAAGAAAGAA	0.383000													147	168					1.2273e-65	2.16949e-65	0.323286	1	0
GON4L	54856	broad.mit.edu	37	1	155783541	155783541	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:155783541T>A	ENST00000437809.1	-	10	1458	c.1336A>T	c.(1336-1338)Atg>Ttg	p.M446L	GON4L_ENST00000368331.1_Missense_Mutation_p.M446L|GON4L_ENST00000361040.5_Missense_Mutation_p.M446L|GON4L_ENST00000271883.5_Missense_Mutation_p.M446L|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	446					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGGGGCCCCATGGGCACTACC	0.517000													30	12					0	0	0.163468	0	0
SYNPR	132204	broad.mit.edu	37	3	63466559	63466559	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:63466559C>A	ENST00000478300.1	+	3	547	c.136C>A	c.(136-138)Cgg>Agg	p.R46R	SYNPR_ENST00000460711.1_Silent_p.R37R|SYNPR_ENST00000479198.1_Silent_p.R26R|SYNPR_ENST00000465156.1_Silent_p.R26R|SYNPR-AS1_ENST00000488201.1_RNA|SYNPR_ENST00000478744.1_3'UTR|SYNPR_ENST00000295894.5_Silent_p.R26R	NM_001130003.1	NP_001123475.1	Q8TBG9	SYNPR_HUMAN	synaptoporin	26	MARVEL.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		TGGAGGCCTGCGGCTGAGTGT	0.453000													133	195					7.10032e-79	1.27329e-78	0.323286	1	0
CACNA1G	8913	broad.mit.edu	37	17	48703714	48703714	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:48703714T>A	ENST00000352832.5	+	34	6727	c.6355T>A	c.(6355-6357)Tgc>Agc	p.C2119S	CACNA1G_ENST00000507609.1_Missense_Mutation_p.C2146S|CACNA1G_ENST00000510366.1_Missense_Mutation_p.C2101S|CACNA1G_ENST00000502264.1_Missense_Mutation_p.C2175S|CACNA1G_ENST00000513689.2_Missense_Mutation_p.C2156S|CACNA1G_ENST00000507896.1_Missense_Mutation_p.C2063S|CACNA1G_ENST00000510115.1_Missense_Mutation_p.C2167S|CACNA1G_ENST00000360761.4_Missense_Mutation_p.C2130S|CACNA1G_ENST00000507510.2_Missense_Mutation_p.C2201S|CACNA1G_ENST00000359106.5_Missense_Mutation_p.C2246S|CACNA1G_ENST00000507336.1_Missense_Mutation_p.C2235S|CACNA1G_ENST00000514079.1_Missense_Mutation_p.C2160S|CACNA1G_ENST00000512389.1_Missense_Mutation_p.C2142S|CACNA1G_ENST00000442258.2_Missense_Mutation_p.C2112S|CACNA1G_ENST00000515165.1_Missense_Mutation_p.C2153S|CACNA1G_ENST00000503485.1_Missense_Mutation_p.C2119S|CACNA1G_ENST00000514181.1_Missense_Mutation_p.C2128S|CACNA1G_ENST00000515765.1_Missense_Mutation_p.C2190S|CACNA1G_ENST00000515411.1_Missense_Mutation_p.C2183S|CACNA1G_ENST00000514717.1_Missense_Mutation_p.C2096S|CACNA1G_ENST00000358244.5_Missense_Mutation_p.C2040S|CACNA1G_ENST00000513964.1_Missense_Mutation_p.C2108S|CACNA1G_ENST00000354983.4_Missense_Mutation_p.C2212S|CACNA1G_ENST00000505165.1_Missense_Mutation_p.C2074S|CACNA1G_ENST00000429973.2_Missense_Mutation_p.C2135S	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	2246					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCTGAAGAAGTGCTACAGCGT	0.647000											OREG0024569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	6					0	0	0.150653	0	0
CLCA4	22802	broad.mit.edu	37	1	87040320	87040320	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:87040320C>A	ENST00000370563.3	+	10	1607	c.1565C>A	c.(1564-1566)aCa>aAa	p.T522K	RP4-651E10.4_ENST00000456587.1_RNA	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	522						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TTTCTCATCACATGGAACAGT	0.428000													43	100					4.44401e-20	5.95033e-20	0.290176	1	0
FAM205BP	389715	broad.mit.edu	37	9	34837087	34837087	+	RNA	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:34837087T>G	ENST00000455647.2	-	0	319																											GAACAGCTCTTGTGGCTTCTG	0.458000													4	21					0	0	0.217242	0	0
SLAMF1	6504	broad.mit.edu	37	1	160582354	160582354	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:160582354A>C	ENST00000302035.6	-	6	1230	c.881T>G	c.(880-882)cTt>cGt	p.L294R	SLAMF1_ENST00000235739.5_Missense_Mutation_p.L264R|SLAMF1_ENST00000538290.1_Silent_p.T269T	NM_003037.2	NP_003028.1	Q13291	SLAF1_HUMAN	signaling lymphocytic activation molecule family member 1	294					interspecies interaction between organisms|lymphocyte activation|positive regulation of cell proliferation	integral to membrane	antigen binding|transmembrane receptor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(52;4.94e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			GAAGGAGTCAAGTTTCTTCTG	0.502000													24	46					0	0	0.279207	0	0
LPHN3	23284	broad.mit.edu	37	4	62542640	62542640	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:62542640A>T	ENST00000512091.1	+	5	1113	c.366A>T	c.(364-366)gaA>gaT	p.E122D	LPHN3_ENST00000507625.1_Missense_Mutation_p.E190D|LPHN3_ENST00000506746.1_Missense_Mutation_p.E190D|LPHN3_ENST00000506700.1_Missense_Mutation_p.E122D|LPHN3_ENST00000508693.1_Missense_Mutation_p.E190D|LPHN3_ENST00000509896.1_Missense_Mutation_p.E190D|LPHN3_ENST00000514591.1_Missense_Mutation_p.E122D|LPHN3_ENST00000545650.1_Missense_Mutation_p.E122D|LPHN3_ENST00000504896.1_Missense_Mutation_p.E122D|LPHN3_ENST00000506720.1_Missense_Mutation_p.E190D|LPHN3_ENST00000507164.1_Missense_Mutation_p.E190D|LPHN3_ENST00000511324.1_Missense_Mutation_p.E190D|LPHN3_ENST00000514996.1_Missense_Mutation_p.E122D|LPHN3_ENST00000508946.1_Missense_Mutation_p.E122D|LPHN3_ENST00000514157.1_Missense_Mutation_p.E122D			Q9HAR2	LPHN3_HUMAN	latrophilin 3	122	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TGCAGTATGAATGTGTCCCTT	0.393000													108	68					0	0	0.323286	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90577112	90577112	+	RNA	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:90577112C>T	ENST00000551025.1	+	0	5540							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		GGGGTGGCTTCTCCATGTCCT	0.433000													11	30					0	0	0.093190	0	0
XIRP1	165904	broad.mit.edu	37	3	39228033	39228033	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:39228033C>T	ENST00000340369.3	-	2	3132	c.2904G>A	c.(2902-2904)gaG>gaA	p.E968E	XIRP1_ENST00000396251.1_Silent_p.E968E|XIRP1_ENST00000421646.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	968							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGATGATGCTCTCAGTTGGGT	0.662000													30	94					0	0	0.183431	0	0
ZGPAT	84619	broad.mit.edu	37	20	62366088	62366088	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:62366088C>A	ENST00000328969.5	+	5	1090	c.963C>A	c.(961-963)acC>acA	p.T321T	ZGPAT_ENST00000448100.1_Silent_p.T301T|ZGPAT_ENST00000355969.6_Silent_p.T301T|ZGPAT_ENST00000490623.1_3'UTR|ZGPAT_ENST00000357119.4_Silent_p.T292T|ZGPAT_ENST00000369967.3_Silent_p.T301T	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	321					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					ACTCTGGGACCTGCAGCTCTG	0.602000													11	38					3.27435e-08	3.62426e-08	0.119110	1	0
ZP4	57829	broad.mit.edu	37	1	238048727	238048727	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:238048727G>T	ENST00000366570.4	-	8	1282	c.1124C>A	c.(1123-1125)cCc>cAc	p.P375H	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	375	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CTGACTCAGGGGGTCAGTGCT	0.547000													28	114					2.65835e-16	3.37829e-16	0.125774	1	0
TRIP12	9320	broad.mit.edu	37	2	230723819	230723819	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:230723819A>T	ENST00000283943.5	-	3	748	c.570T>A	c.(568-570)tgT>tgA	p.C190*	TRIP12_ENST00000389044.4_Nonsense_Mutation_p.C232*|TRIP12_ENST00000409677.1_Nonsense_Mutation_p.C232*|TRIP12_ENST00000543084.1_Nonsense_Mutation_p.C232*|TRIP12_ENST00000389045.3_Intron	NM_004238.1	NP_004229.1	Q14669	TRIPC_HUMAN	thyroid hormone receptor interactor 12	190					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	proteasome complex	thyroid hormone receptor binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(19)|lung(32)|ovary(5)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.126)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;4.76e-13)|all cancers(144;4.34e-10)|LUSC - Lung squamous cell carcinoma(224;0.00864)|Lung(119;0.0116)		TGATGGTGCTACACCCAGCTT	0.532000													43	51					0	0	0.323286	0	0
PZP	5858	broad.mit.edu	37	12	9344805	9344805	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:9344805A>T	ENST00000261336.2	-	13	1558	c.1530T>A	c.(1528-1530)ccT>ccA	p.P510P	PZP_ENST00000381997.2_Silent_p.P379P	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						CTGACTCCACAGGCAGAGTGT	0.473000													63	122					0	0	0.323286	0	0
PCLO	27445	broad.mit.edu	37	7	82584925	82584925	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:82584925C>A	ENST00000423517.2	-	5	5681	c.5344G>T	c.(5344-5346)Gaa>Taa	p.E1782*	PCLO_ENST00000333891.8_Nonsense_Mutation_p.E1782*	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1713					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AATTCTTCTTCCTCTCTCAAT	0.393000													163	399					1.28668e-78	2.30604e-78	0.323286	1	0
SMYD1	150572	broad.mit.edu	37	2	88396283	88396283	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:88396283G>A	ENST00000419482.2	+	6	953	c.868G>A	c.(868-870)Ggg>Agg	p.G290R	SMYD1_ENST00000444564.2_Missense_Mutation_p.G277R|SMYD1_ENST00000438570.1_Intron	NM_198274.3	NP_938015.1	Q8NB12	SMYD1_HUMAN	SET and MYND domain containing 1	290					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding	p.G290R(1)		NS(1)|breast(4)|central_nervous_system(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	41						CCTCTTCCTGGGGGTGAAAGA	0.507000													67	102					0	0	0.323286	0	0
SLC22A18	5002	broad.mit.edu	37	11	2940624	2940624	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:2940624G>T	ENST00000380574.1	+	8	1282	c.851G>T	c.(850-852)gGg>gTg	p.G284V	SLC22A18_ENST00000347936.2_Missense_Mutation_p.G284V|SLC22A18_ENST00000312221.5_Missense_Mutation_p.G284V|SLC22A18_ENST00000441077.1_3'UTR|SLC22A18_ENST00000449793.2_Missense_Mutation_p.G186V			Q96BI1	S22AI_HUMAN	solute carrier family 22, member 18	284					excretion|organic cation transport	apical plasma membrane|cytoplasmic part|integral to membrane|nuclear envelope	drug:hydrogen antiporter activity|symporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	8		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.00256)|LUSC - Lung squamous cell carcinoma(625;0.192)		TCCTTCTTCGGGCTCCTCCAG	0.647000													17	2					3.51602e-12	4.18973e-12	0.204396	1	0
SARDH	1757	broad.mit.edu	37	9	136573493	136573493	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:136573493C>A	ENST00000371872.4	-	11	1643	c.1386G>T	c.(1384-1386)gaG>gaT	p.E462D	SARDH_ENST00000439388.1_Missense_Mutation_p.E462D|SARDH_ENST00000422262.2_Missense_Mutation_p.E294D	NM_007101.3	NP_009032.2	Q9UL12	SARDH_HUMAN	sarcosine dehydrogenase	462					glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|sarcosine dehydrogenase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(13)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	44				OV - Ovarian serous cystadenocarcinoma(145;3.21e-07)|Epithelial(140;2.37e-06)|all cancers(34;2.75e-05)		TGGCGTAGGACTCATGGCTTC	0.657000													29	0					3.54561e-26	5.1002e-26	0.279185	1	0
CEP164	22897	broad.mit.edu	37	11	117278678	117278678	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:117278678G>T	ENST00000278935.3	+	28	3686	c.3539G>T	c.(3538-3540)cGg>cTg	p.R1180L	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	1180					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		TCGGCCATGCGGAAAGGCCAC	0.542000													12	20					0.00185496	0.00191366	0.105934	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798664	55798664	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55798664T>G	ENST00000313555.1	+	1	770	c.770T>G	c.(769-771)tTt>tGt	p.F257C		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					GCGCTCCTGTTTATGTACTTA	0.428000													65	115					0	0	0.323286	0	0
SMIM8	57150	broad.mit.edu	37	6	88049910	88049910	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:88049910A>T	ENST00000392863.1	+	4	301	c.212A>T	c.(211-213)cAa>cTa	p.Q71L	SMIM8_ENST00000229570.5_Missense_Mutation_p.Q71L	NM_001042493.1	NP_001035958.1			small integral membrane protein 8																		CATGCAATACAAGAGAATAAA	0.373000													48	80					0	0	0.323286	0	0
OR2M3	127062	broad.mit.edu	37	1	248366647	248366647	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248366647C>G	ENST00000456743.1	+	1	316	c.278C>G	c.(277-279)tCt>tGt	p.S93C		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	93					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AAGTCCATTTCTATGGCTGGT	0.493000													189	550					0	0	0.323286	0	0
PTPN14	5784	broad.mit.edu	37	1	214576226	214576226	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:214576226C>A	ENST00000366956.5	-	6	775	c.581_splice	c.e6+1	p.S194_splice	PTPN14_ENST00000543945.1_Splice_Site_p.R194_splice	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	194	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CCTGCCTTACCTGTGGGCTTT	0.537000													161	508					6.93e-98	1.26248e-97	0.323286	1	0
NUP43	348995	broad.mit.edu	37	6	150064774	150064774	+	Splice_Site	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:150064774C>G	ENST00000340413.2	-	3	397	c.321_splice	c.e3+1	p.Q107_splice	NUP43_ENST00000367403.3_Splice_Site_p.Q168_splice|NUP43_ENST00000463048.3_5'UTR|NUP43_ENST00000367404.4_Splice_Site_p.Q107_splice|NUP43_ENST00000460354.2_Splice_Site_p.Q107_splice	NM_198887.1	NP_942590.1	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	107					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			breast(1)|large_intestine(2)|lung(8)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		AGTTCTTTACCTGGTTATTTG	0.403000													4	12					0	0	0.184627	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74540441	74540441	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:74540441T>C	ENST00000354431.4	-	6	1092	c.901A>G	c.(901-903)Agt>Ggt	p.S301G	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.S301G	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	301										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						CTGTGTTCACTGGAATTTTTT	0.274000													16	38					0	0	0.204396	0	0
IFT74	80173	broad.mit.edu	37	9	26990194	26990194	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:26990194G>T	ENST00000443698.1	+	8	758		c.e8+1		IFT74_ENST00000429045.2_Splice_Site|IFT74_ENST00000380062.5_Splice_Site|IFT74_ENST00000433700.1_Splice_Site	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)							cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		AAAGACAAGCGTAAGTATAGC	0.269000													26	68					2.48779e-11	2.92066e-11	0.324025	1	0
CUL9	23113	broad.mit.edu	37	6	43164002	43164002	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:43164002G>T	ENST00000252050.4	+	10	2668	c.2585_splice	c.e10+1	p.G862_splice	CUL9_ENST00000372647.2_Splice_Site_p.G862_splice|CUL9_ENST00000354495.3_Splice_Site_p.G752_splice	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	862					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						GAATACTGAGGGGTCAGGGCA	0.582000													41	87					8.72198e-27	1.25989e-26	0.323286	1	0
PANX1	24145	broad.mit.edu	37	11	93912879	93912879	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:93912879G>C	ENST00000227638.3	+	4	1042	c.657G>C	c.(655-657)ctG>ctC	p.L219L	PANX1_ENST00000436171.2_Silent_p.L219L	NM_015368.3	NP_056183.2	Q96RD7	PANX1_HUMAN	pannexin 1	219					positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding			endometrium(2)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				GCCGCCTGCTGACACTCATCA	0.418000													28	53					0	0	0.144211	0	0
GRM4	2914	broad.mit.edu	37	6	34026759	34026759	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:34026759G>T	ENST00000374181.3	-	4	1188	c.1019C>A	c.(1018-1020)tCc>tAc	p.S340Y	GRM4_ENST00000544773.1_Missense_Mutation_p.S171Y|GRM4_ENST00000538487.1_Missense_Mutation_p.S340Y|GRM4_ENST00000535756.1_Missense_Mutation_p.S207Y|GRM4_ENST00000455714.2_Missense_Mutation_p.S200Y|GRM4_ENST00000374177.3_Missense_Mutation_p.S271Y|GRM4_ENST00000545715.1_Missense_Mutation_p.S32Y	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	340					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	ACCTCGTACGGACATCCTCTT	0.632000													18	11					3.99206e-14	4.91001e-14	0.189662	1	0
EPB41L1	2036	broad.mit.edu	37	20	34761755	34761755	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:34761755C>T	ENST00000338074.2	+	2	217	c.56C>T	c.(55-57)cCg>cTg	p.P19L	EPB41L1_ENST00000373941.1_Missense_Mutation_p.P19L|EPB41L1_ENST00000202028.5_Intron|EPB41L1_ENST00000373950.2_Intron|EPB41L1_ENST00000441639.1_Intron|EPB41L1_ENST00000373946.3_Intron	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	19					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					GAGGAGGCCCCGCAGCAGCCC	0.622000													21	29					0	0	0.173368	0	0
LINC00202-1	387644	broad.mit.edu	37	10	27223368	27223368	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:27223368C>A	ENST00000431296.1	-	0	3236					NR_026795.1																						TGTGTTTGGGCCTTTTCCAGA	0.498000													99	138					7.22319e-40	1.16451e-39	0.323286	1	0
PREX2	80243	broad.mit.edu	37	8	69046447	69046447	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:69046447G>T	ENST00000288368.4	+	32	4197	c.3920G>T	c.(3919-3921)tGg>tTg	p.W1307L		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1307					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AGCAGGAGGTGGCTGGACCAG	0.483000													57	77					8.72158e-25	1.23562e-24	0.323286	1	0
MFAP3	4238	broad.mit.edu	37	5	153432624	153432624	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:153432624T>C	ENST00000436816.1	+	3	659	c.440T>C	c.(439-441)aTg>aCg	p.M147T	MFAP3_ENST00000322602.5_Missense_Mutation_p.M147T|MFAP3_ENST00000439768.2_Start_Codon_SNP_p.M1T	NM_001242336.1|NM_005927.4	NP_001229265.1|NP_005918.1	P55082	MFAP3_HUMAN	microfibrillar-associated protein 3	147						integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)	7	Renal(175;0.00488)	Lung NSC(249;0.00145)|all_lung(500;0.00226)|all_neural(177;0.122)|Breast(839;0.14)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;9.69e-06)|GBM - Glioblastoma multiforme(465;0.0201)		TCGGGAGACATGAGTGTCTAT	0.473000													35	46					0	0	0.203993	0	0
TRBC2	28638	broad.mit.edu	37	7	142498826	142498826	+	RNA	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142498826G>A	ENST00000466254.1	+	0	102																											CCTGGCCACAGGCTTCTACCC	0.617000													72	340					0	0	0.323286	0	0
ICOS	29851	broad.mit.edu	37	2	204801541	204801541	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:204801541A>T	ENST00000316386.6	+	1	71	c.4A>T	c.(4-6)Aag>Tag	p.K2*	ICOS_ENST00000435193.1_Nonsense_Mutation_p.K2*	NM_012092.3	NP_036224.1	Q9Y6W8	ICOS_HUMAN	inducible T-cell co-stimulator	2					immune response|T cell costimulation	extracellular region				breast(1)|large_intestine(1)|lung(4)	6						GGCAAACATGAAGTCAGGCCT	0.383000													13	152					0	0	0.132662	0	0
NCAN	1463	broad.mit.edu	37	19	19339016	19339016	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19339016G>T	ENST00000252575.5	+	8	2630	c.2587G>T	c.(2587-2589)Gtg>Ttg	p.V863L	NCAN_ENST00000538881.1_Missense_Mutation_p.V314L	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	863					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding	p.V877L(1)|p.V863L(1)		breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GAGCCCTCAGGTGGCCCTGGA	0.587000													45	48					8.72198e-27	1.25989e-26	0.323286	1	0
DNAH11	8701	broad.mit.edu	37	7	21698650	21698650	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:21698650G>T	ENST00000328843.6	+	30	5374		c.e30+1		DNAH11_ENST00000409508.3_Splice_Site			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11						microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TAAAAAACAGGTATTACATAG	0.383000									Kartagener syndrome				43	80					1.57945e-13	1.92506e-13	0.301197	1	0
LST3	0	broad.mit.edu	37	12	21207570	21207570	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:21207570G>T	ENST00000381541.3	+	11	1747	c.1682_splice	c.e11+1	p.R561_splice	SLCO1B7_ENST00000421593.2_Splice_Site_p.R514_splice|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000554957.1_Splice_Site_p.R561_splice|SLCO1B3_ENST00000553473.1_Intron|RP11-125O5.2_ENST00000590779.1_Splice_Site_p.G15_splice																							CTGGTGATTAGGTAAGTATGA	0.308000													6	49					8.12818e-05	8.55061e-05	0.248553	1	0
CHRM2	1129	broad.mit.edu	37	7	136700640	136700640	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:136700640C>A	ENST00000445907.2	+	3	1556	c.1028C>A	c.(1027-1029)aCc>aAc	p.T343N	CHRM2_ENST00000320658.5_Missense_Mutation_p.T343N|AC009264.1_ENST00000593789.1_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.T343N|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000402486.3_Missense_Mutation_p.T343N|AC009264.1_ENST00000597642.1_RNA|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000439694.1_RNA|CHRM2_ENST00000401861.1_Missense_Mutation_p.T343N|CHRM2_ENST00000453373.1_Missense_Mutation_p.T343N	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	343					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	ACTAATACCACCGTGGAGGTA	0.458000													78	292					4.38691e-48	7.32808e-48	0.323286	1	0
WNK4	65266	broad.mit.edu	37	17	40937188	40937188	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:40937188C>A	ENST00000246914.5	+	5	1265	c.1244C>A	c.(1243-1245)aCg>aAg	p.T415K		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	415	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TGCATCCGCACGGATAAGAAC	0.617000													12	31					1.61879e-10	1.86788e-10	0.093190	1	0
B4GALNT2	124872	broad.mit.edu	37	17	47247044	47247044	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:47247044A>C	ENST00000300404.2	+	11	1714	c.1655A>C	c.(1654-1656)aAg>aCg	p.K552T	B4GALNT2_ENST00000504681.1_Missense_Mutation_p.K466T|B4GALNT2_ENST00000393354.2_Missense_Mutation_p.K492T	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	552					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			GTCCAGTTCAAGCTGGCCCTC	0.532000													5	37					0	0	0.217242	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130341208	130341208	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:130341208G>T	ENST00000299164.2	+	7	2008	c.2008G>T	c.(2008-2010)Gac>Tac	p.D670Y		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	670	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		GAAGAGATTCGACAAGTGTGG	0.577000													13	42					9.31168e-06	9.94423e-06	0.105934	1	0
CDH7	1005	broad.mit.edu	37	18	63526210	63526210	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:63526210C>A	ENST00000536984.2	+	9	2116	c.1422C>A	c.(1420-1422)gaC>gaA	p.D474E	CDH7_ENST00000323011.3_Missense_Mutation_p.D474E|CDH7_ENST00000397968.2_Missense_Mutation_p.D474E			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	474	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				CTATACTTGACATCAATGATA	0.438000													83	43					4.92795e-40	7.94888e-40	0.323286	1	0
PTPRD	5789	broad.mit.edu	37	9	8485850	8485850	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:8485850T>C	ENST00000381196.4	-	25	3510	c.2967A>G	c.(2965-2967)acA>acG	p.T989T	PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Silent_p.T989T|PTPRD_ENST00000360074.4_Silent_p.T976T|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Silent_p.T989T|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000358503.5_Silent_p.T967T	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	989	Fibronectin type-III 7.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTACATCGTATGTGGTATCTG	0.483000										TSP Lung(15;0.13)			70	75					0	0	0.323286	0	0
C1orf158	93190	broad.mit.edu	37	1	12819346	12819346	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:12819346G>T	ENST00000288048.5	+	3	545	c.329G>T	c.(328-330)gGg>gTg	p.G110V	C1orf158_ENST00000376210.3_Missense_Mutation_p.G72V	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	110										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		TACAACCCGGGGCTGCCTCCA	0.527000													65	148					2.79064e-53	4.77228e-53	0.323286	1	0
TM9SF2	9375	broad.mit.edu	37	13	100188942	100188942	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:100188942G>T	ENST00000376387.4	+	5	732	c.542G>T	c.(541-543)gGc>gTc	p.G181V	TM9SF2_ENST00000463709.1_3'UTR	NM_004800.1	NP_004791.1	Q99805	TM9S2_HUMAN	transmembrane 9 superfamily member 2	181					transport	endosome membrane|integral to plasma membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)	17	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.218)					TTTCCTATTGGCTGTTACATT	0.383000													21	144					8.10497e-08	8.93278e-08	0.219247	1	0
PCDH15	65217	broad.mit.edu	37	10	56129003	56129003	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:56129003C>A	ENST00000373965.2	-	5	745	c.351G>T	c.(349-351)caG>caT	p.Q117H	PCDH15_ENST00000395445.1_Missense_Mutation_p.Q117H|PCDH15_ENST00000395430.1_Missense_Mutation_p.Q117H|PCDH15_ENST00000437009.1_Missense_Mutation_p.Q117H|PCDH15_ENST00000395438.1_Missense_Mutation_p.Q117H|PCDH15_ENST00000395433.1_Missense_Mutation_p.Q95H|PCDH15_ENST00000373955.1_Missense_Mutation_p.Q117H|PCDH15_ENST00000395446.1_Missense_Mutation_p.Q117H|PCDH15_ENST00000320301.6_Missense_Mutation_p.Q117H|PCDH15_ENST00000414778.1_Missense_Mutation_p.Q122H|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.Q117H|PCDH15_ENST00000395442.1_Missense_Mutation_p.Q117H|PCDH15_ENST00000395440.1_Missense_Mutation_p.Q117H|PCDH15_ENST00000373957.3_Missense_Mutation_p.Q95H|PCDH15_ENST00000361849.3_Missense_Mutation_p.Q117H	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	117	Cadherin 1.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				TGCACTGGACCTGCACCACAA	0.398000										HNSCC(58;0.16)			51	3					1.84395e-34	2.86971e-34	0.323286	1	0
RPF1	80135	broad.mit.edu	37	1	84955400	84955400	+	Silent	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:84955400A>C	ENST00000370654.5	+	4	466	c.451A>C	c.(451-453)Aga>Cga	p.R151R		NM_025065.6	NP_079341.2	Q9H9Y2	RPF1_HUMAN	ribosome production factor 1 homolog (S. cerevisiae)	151	Brix.				rRNA processing|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|rRNA binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(2)|prostate(1)	14						AACATCAGATAGACCTCATGG	0.333000													50	30					0	0	0.323286	0	0
OR52K1	390036	broad.mit.edu	37	11	4510679	4510679	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:4510679C>A	ENST00000307632.3	+	1	571	c.549C>A	c.(547-549)caC>caA	p.H183Q		NM_001005171.2	NP_001005171.2	Q8NGK4	O52K1_HUMAN	olfactory receptor, family 52, subfamily K, member 1	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(18)|skin(2)|stomach(1)	32		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.76e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0836)|LUSC - Lung squamous cell carcinoma(625;0.192)		ACTGTGAACACATGGCTGTGG	0.532000													206	16					6.59115e-116	1.21288e-115	0.323286	1	0
LRP1B	53353	broad.mit.edu	37	2	141081474	141081474	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:141081474T>A	ENST00000389484.3	-	81	13473	c.12502A>T	c.(12502-12504)Aaa>Taa	p.K4168*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4168					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTAGTTGTTTATAACGATGA	0.239000										TSP Lung(27;0.18)			35	72					0	0	0.235728	0	0
POLG2	11232	broad.mit.edu	37	17	62492735	62492735	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:62492735C>A	ENST00000539111.2	-	1	419	c.352G>T	c.(352-354)Gtg>Ttg	p.V118L		NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	118				WWTSVVVFREQ -> MVDLGGGVHGA (in Ref. 5; AAC51321).	DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			AACACCACCACCGAGGTCCAC	0.612000													29	84					1.26612e-14	1.57161e-14	0.183431	1	0
WDR87	83889	broad.mit.edu	37	19	38384746	38384746	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:38384746A>G	ENST00000447313.2	-	4	1757	c.1597T>C	c.(1597-1599)Tat>Cat	p.Y533H	WDR87_ENST00000303868.5_Missense_Mutation_p.Y494H			Q6ZQQ6	WDR87_HUMAN	WD repeat domain 87	494										NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(2)|prostate(1)|skin(3)|stomach(1)	36						AGGTGCACATAGTCATCCATT	0.507000													8	13					0	0	0.307466	0	0
MYT1L	23040	broad.mit.edu	37	2	1946754	1946754	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:1946754C>A	ENST00000399161.2	-	9	1252	c.505_splice	c.e9+1	p.E169_splice	MYT1L_ENST00000428368.2_Splice_Site_p.E169_splice	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	169	Asp/Glu-rich.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TAAAGATTACCGTTTtcttct	0.453000													11	10					6.40141e-05	6.75935e-05	0.080935	1	0
IGSF10	285313	broad.mit.edu	37	3	151163146	151163146	+	Silent	SNP	G	G	A	rs146031878		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:151163146G>A	ENST00000282466.3	-	4	4622	c.4623C>T	c.(4621-4623)ttC>ttT	p.F1541F		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1541					cell differentiation|multicellular organismal development|ossification	extracellular region		p.F1541F(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TAGAGTAGATGAAGTGAGTGG	0.428000													44	134					0	0	0.323286	0	0
PLCB2	5330	broad.mit.edu	37	15	40591413	40591413	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:40591413G>T	ENST00000260402.3	-	8	848	c.599C>A	c.(598-600)cCt>cAt	p.P200H	PLCB2_ENST00000456256.2_Missense_Mutation_p.P200H|PLCB2_ENST00000557821.1_Missense_Mutation_p.P200H	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	200					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GAAGTCCTCAGGATTGATGGC	0.507000													56	12					9.40535e-28	1.37463e-27	0.323286	1	0
OR5AP2	338675	broad.mit.edu	37	11	56409188	56409188	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56409188G>A	ENST00000544374.1	-	1	759	c.731C>T	c.(730-732)gCc>gTc	p.A244V	OR5AP2_ENST00000302981.1_Missense_Mutation_p.A243V			Q8NGF4	O5AP2_HUMAN	olfactory receptor, family 5, subfamily AP, member 2	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	29						GGTGGAGAAGGCTTTGTGCCT	0.453000													107	252					0	0	0.323286	0	0
TMEM169	92691	broad.mit.edu	37	2	216964965	216964965	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:216964965G>T	ENST00000454545.1	+	4	920	c.594G>T	c.(592-594)agG>agT	p.R198S	TMEM169_ENST00000437356.2_Missense_Mutation_p.R198S|TMEM169_ENST00000406027.2_Missense_Mutation_p.R198S|TMEM169_ENST00000295658.4_Missense_Mutation_p.R198S	NM_001142310.1	NP_001135782.1	Q96HH4	TM169_HUMAN	transmembrane protein 169	198						integral to membrane				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)	13		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ATGAGGAAAGGACCTTCTGGC	0.493000													106	939					8.84886e-50	1.48859e-49	0.323286	1	0
AP4E1	23431	broad.mit.edu	37	15	51240291	51240291	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:51240291A>T	ENST00000261842.5	+	11	1357	c.1251A>T	c.(1249-1251)ttA>ttT	p.L417F	AP4E1_ENST00000560508.1_Missense_Mutation_p.L342F	NM_001252127.1|NM_007347.4	NP_001239056.1|NP_031373.2	Q9UPM8	AP4E1_HUMAN	adaptor-related protein complex 4, epsilon 1 subunit	417					intracellular protein transport|vesicle-mediated transport	COPI vesicle coat	binding|structural molecule activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(5)|skin(2)	27				all cancers(107;0.000893)|GBM - Glioblastoma multiforme(94;0.00364)		TTGAATATTTACATCAGAGCA	0.323000													27	18					0	0	0.116897	0	0
ATP8B4	79895	broad.mit.edu	37	15	50154462	50154462	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:50154462A>G	ENST00000284509.6	-	27	3418	c.3277T>C	c.(3277-3279)Tac>Cac	p.Y1093H	ATP8B4_ENST00000559829.1_Missense_Mutation_p.Y1093H	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1093					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AGGGTTGGGTATAAATCCACC	0.438000													13	34					0	0	0.105934	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101606329	101606329	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:101606329T>A	ENST00000310954.6	-	3	1087	c.802_splice	c.e3+1	p.I267_splice		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	267					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TAAACTTACCTATATAGAGAG	0.373000													70	70					0	0	0.323286	0	0
BRINP2	57795	broad.mit.edu	37	1	177250527	177250527	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:177250527G>C	ENST00000361539.4	+	8	2527	c.2215G>C	c.(2215-2217)Gac>Cac	p.D739H	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		739						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						AGTCCGACTTGACCTTTTCTC	0.542000													74	156					0	0	0.323286	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66963826	66963826	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:66963826C>A	ENST00000276570.5	+	3	331	c.44C>A	c.(43-45)aCa>aAa	p.T15K	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	15					protein folding	membrane	heat shock protein binding|unfolded protein binding			endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			ACTCTGTCAACAACAGGAGAA	0.403000													60	57					7.73544e-29	1.14079e-28	0.323286	1	0
C17orf47	284083	broad.mit.edu	37	17	56620460	56620460	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:56620460G>A	ENST00000321691.3	-	1	1269	c.1088C>T	c.(1087-1089)tCc>tTc	p.S363F	RP11-112H10.4_ENST00000580769.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580589.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	363										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AACAAACATGGATGACTTGTG	0.512000													19	71					0	0	0.249174	0	0
C1orf52	148423	broad.mit.edu	37	1	85725170	85725170	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:85725170C>A	ENST00000471115.1	-	1	155	c.147G>T	c.(145-147)agG>agT	p.R49S	C1orf52_ENST00000294661.4_5'UTR|C1orf52_ENST00000344356.5_Missense_Mutation_p.R49S	NM_198077.3	NP_932343.1	Q8N6N3	CA052_HUMAN	chromosome 1 open reading frame 52	49										endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)	10				all cancers(265;0.0105)|Epithelial(280;0.0293)		CCGCCTTGTTCCTACAGCCGC	0.627000											OREG0013580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	5					0.000157383	0.000164723	0.278610	1	0
SH3TC2	79628	broad.mit.edu	37	5	148407710	148407710	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:148407710G>T	ENST00000538184.1	-	7	1114	c.226C>A	c.(226-228)Cgt>Agt	p.R76S	SH3TC2_ENST00000512049.1_Missense_Mutation_p.R522S|SH3TC2_ENST00000515425.1_Missense_Mutation_p.R529S|SH3TC2_ENST00000394358.2_Missense_Mutation_p.R414S			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	529							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGCAGAGACGGGCATGGGCC	0.542000													79	97					1.48072e-28	2.18059e-28	0.323286	1	0
OR4D2	124538	broad.mit.edu	37	17	56247355	56247355	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:56247355C>T	ENST00000545221.1	+	1	339	c.339C>T	c.(337-339)ttC>ttT	p.F113F		NM_001004707.3	NP_001004707.1	P58180	OR4D2_HUMAN	olfactory receptor, family 4, subfamily D, member 2	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(1)|lung(19)|ovary(1)|skin(2)|stomach(1)	26						CCATGGTCTTCTTCCTCTCAG	0.542000													75	189					0	0	0.323286	0	0
DMXL2	23312	broad.mit.edu	37	15	51830521	51830521	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:51830521G>A	ENST00000251076.5	-	10	1521	c.1234C>T	c.(1234-1236)Cga>Tga	p.R412*	DMXL2_ENST00000543779.2_Nonsense_Mutation_p.R412*|DMXL2_ENST00000449909.3_Nonsense_Mutation_p.R412*	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	412						cell junction|synaptic vesicle membrane	Rab GTPase binding	p.R412*(1)		breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		GAAAGTTTTCGTAATTGATGC	0.343000													42	88					0	0	0.268233	0	0
FAM83F	113828	broad.mit.edu	37	22	40417319	40417319	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:40417319G>T	ENST00000333407.5	+	4	899	c.805G>T	c.(805-807)Gac>Tac	p.D269Y	FAM83F_ENST00000473717.1_3'UTR	NM_138435.2	NP_612444.2	Q8NEG4	FA83F_HUMAN	family with sequence similarity 83, member F	269										breast(1)|endometrium(2)|large_intestine(1)|lung(4)|skin(4)|urinary_tract(2)	14						CTCCCATGTGGACAGAAACCT	0.607000													150	13					2.05284e-59	3.58986e-59	0.323286	1	0
SMCHD1	23347	broad.mit.edu	37	18	2688415	2688415	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:2688415C>T	ENST00000320876.6	+	6	1000	c.662C>T	c.(661-663)cCa>cTa	p.P221L	SMCHD1_ENST00000261598.8_Missense_Mutation_p.P221L	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	221					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						TATGTTCGTCCAGTACCAGTG	0.363000													42	7					0	0	0.312237	0	0
ARID1A	8289	broad.mit.edu	37	1	27105553	27105553	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:27105553C>T	ENST00000324856.7	+	20	5535	c.5164C>T	c.(5164-5166)Cga>Tga	p.R1722*	ARID1A_ENST00000457599.2_Nonsense_Mutation_p.R1505*|ARID1A_ENST00000374152.2_Nonsense_Mutation_p.R1339*|ARID1A_ENST00000540690.1_Nonsense_Mutation_p.R50*	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1722					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding	p.R1722*(5)	ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		ATATTTCCGACGATGCCTGAT	0.443000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								128	285					0	0	0.323286	0	0
PHF3	23469	broad.mit.edu	37	6	64422495	64422495	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:64422495G>A	ENST00000262043.3	+	16	5351	c.5011G>A	c.(5011-5013)Gat>Aat	p.D1671N	PHF3_ENST00000393387.1_Missense_Mutation_p.D1671N			Q92576	PHF3_HUMAN	PHD finger protein 3	1671					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			CAAAGATGGAGATAGTTGCCG	0.453000													28	99					0	0	0.134883	0	0
HAUS6	54801	broad.mit.edu	37	9	19080548	19080548	+	Silent	SNP	C	C	A	rs139689694	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:19080548C>A	ENST00000380502.3	-	9	1460	c.993G>T	c.(991-993)acG>acT	p.T331T	HAUS6_ENST00000380496.1_Silent_p.T195T	NM_017645.3	NP_060115.3	Q7Z4H7	HAUS6_HUMAN	HAUS augmin-like complex, subunit 6	331					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleus|spindle				autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GAAGGTCTACCGTCAATCTTG	0.353000													76	137					2.71351e-25	3.86913e-25	0.323286	1	0
MUC16	94025	broad.mit.edu	37	19	9002505	9002505	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:9002505G>T	ENST00000397910.4	-	51	40514	c.40311C>A	c.(40309-40311)gtC>gtA	p.V13437V	MUC16_ENST00000380951.5_Silent_p.V78V	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13439	SEA 9.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCTCACCATTGACATAGAGAC	0.567000													439	595					7.31064e-103	1.33733e-102	0.323286	1	0
DPY19L3	147991	broad.mit.edu	37	19	32971438	32971438	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:32971438A>G	ENST00000342179.5	+	18	2179	c.1964A>G	c.(1963-1965)gAc>gGc	p.D655G	DPY19L3_ENST00000586987.1_Missense_Mutation_p.D655G|DPY19L3_ENST00000392250.2_Missense_Mutation_p.D655G	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	655						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					CGACTCCGGGACCTGCTGGAC	0.602000													7	28					0	0	0.307466	0	0
AHSP	51327	broad.mit.edu	37	16	31539908	31539908	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:31539908G>A	ENST00000302312.4	+	3	308	c.205G>A	c.(205-207)Gag>Aag	p.E69K	AHSP_ENST00000569954.1_3'UTR	NM_016633.2	NP_057717.1	Q9NZD4	AHSP_HUMAN	alpha hemoglobin stabilizing protein	69					hemoglobin metabolic process|hemopoiesis|protein folding|protein stabilization	hemoglobin complex	hemoglobin binding|unfolded protein binding			lung(2)	2						GGCTCTGCAGGAGCTTCGGCA	0.567000													27	36					0	0	0.163468	0	0
GP2	2813	broad.mit.edu	37	16	20335513	20335513	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:20335513G>T	ENST00000302555.5	-	3	309	c.160C>A	c.(160-162)Cca>Aca	p.P54T	GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.P54T|GP2_ENST00000341642.5_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	54						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TGAGCCTCTGGGGTGCCAGGA	0.547000													110	13					1.45828e-52	2.48284e-52	0.323286	1	0
C11orf70	85016	broad.mit.edu	37	11	101953855	101953855	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:101953855T>G	ENST00000434758.2	+	7	757	c.729T>G	c.(727-729)tcT>tcG	p.S243S		NM_032930.2	NP_116319.2	Q9BRQ4	CK070_HUMAN	chromosome 11 open reading frame 70	243										breast(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|skin(2)	12	all_epithelial(12;0.0137)	Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.0137)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0335)		AGACATTTTCTTACTTTATTG	0.328000													10	109					0	0	0.080935	0	0
RAD23B	5887	broad.mit.edu	37	9	110087176	110087176	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:110087176G>T	ENST00000358015.3	+	9	1358	c.1007G>T	c.(1006-1008)gGt>gTt	p.G336V	RAD23B_ENST00000416373.2_Missense_Mutation_p.G264V	NM_001244713.1|NM_002874.4	NP_001231642.1|NP_002865.1	P54727	RD23B_HUMAN	RAD23 homolog B (S. cerevisiae)	336	Poly-Gly.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			breast(3)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						CAAGAAGCTGGTGGTCAAGGA	0.428000								Direct reversal of damage;Nucleotide excision repair (NER)					46	38					8.86878e-18	1.14731e-17	0.323286	1	0
ZAN	7455	broad.mit.edu	37	7	100389700	100389700	+	RNA	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100389700A>G	ENST00000542585.1	+	0	7787				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CCAGGCCTGTAGGGTGCTGGC	0.667000													6	27					0	0	0.217242	0	0
TENM3	55714	broad.mit.edu	37	4	183650131	183650131	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:183650131C>T	ENST00000511685.1	+	14	2505	c.2382C>T	c.(2380-2382)gaC>gaT	p.D794D	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Silent_p.D794D					teneurin transmembrane protein 3																		GACTCATTGACTGCATGGATC	0.433000													38	14					0	0	0.268233	0	0
DNAH1	25981	broad.mit.edu	37	3	52392660	52392660	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:52392660C>T	ENST00000420323.2	+	25	4434	c.4173C>T	c.(4171-4173)tcC>tcT	p.S1391S		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1391	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCTACCCCTCCAGCAACGTGG	0.602000													10	13					0	0	0.146539	0	0
TRPM6	140803	broad.mit.edu	37	9	77386753	77386753	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:77386753T>A	ENST00000451710.3	-	25	3641		c.e25-2		TRPM6_ENST00000361255.3_Splice_Site|TRPM6_ENST00000360774.1_Splice_Site|TRPM6_ENST00000449912.2_Splice_Site|TRPM6_ENST00000376864.4_Splice_Site|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6						response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						GGTAGAGTTCTATAGAAATAA	0.368000													22	42					0	0	0.264190	0	0
RNF213	57674	broad.mit.edu	37	17	78359421	78359421	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:78359421G>T	ENST00000582970.1	+	61	14682	c.14539_splice	c.e61+1	p.G4847_splice	RNF213_ENST00000427003.3_3'UTR|RNF213_ENST00000336301.6_Splice_Site_p.G2920_splice|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Splice_Site_p.G4896_splice|CTD-2047H16.4_ENST00000573394.1_RNA|CTD-2047H16.4_ENST00000575034.1_RNA	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	1222										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			TGAGACGAACGGTTAGTATCC	0.522000													26	15					6.38683e-12	7.57565e-12	0.134883	1	0
REG1A	5967	broad.mit.edu	37	2	79348699	79348699	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:79348699C>A	ENST00000233735.1	+	3	179	c.76C>A	c.(76-78)Cag>Aag	p.Q26K		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	26					positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						CCAAGAGGCCCAGACAGAGTT	0.502000													206	354					2.66718e-116	4.9139e-116	0.323286	1	0
N4BP2L2	10443	broad.mit.edu	37	13	33016677	33016677	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:33016677C>G	ENST00000357505.6	-	7	2056	c.1952G>C	c.(1951-1953)aGa>aCa	p.R651T	N4BP2L2_ENST00000380121.3_5'UTR|N4BP2L2_ENST00000399396.3_Missense_Mutation_p.R666T|N4BP2L2_ENST00000446957.2_Missense_Mutation_p.R569T|N4BP2L2_ENST00000504114.1_Missense_Mutation_p.R651T	NM_001278432.1	NP_001265361.1	Q92802	N42L2_HUMAN	NEDD4 binding protein 2-like 2	0										kidney(4)|large_intestine(3)|liver(1)|lung(6)|skin(1)|urinary_tract(1)	16		Lung SC(185;0.0262)		all cancers(112;9.5e-07)|Epithelial(112;5.07e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00196)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.243)		TTTCAGCTTTCTATCAAACCT	0.398000													17	18					0	0	0.160694	0	0
GGH	8836	broad.mit.edu	37	8	63948275	63948275	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:63948275T>C	ENST00000260118.6	-	2	566	c.164A>G	c.(163-165)tAt>tGt	p.Y55C		NM_003878.2	NP_003869.1	Q92820	GGH_HUMAN	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	55	Gamma-glutamyl hydrolase.				glutamine metabolic process	extracellular space|lysosome|melanosome	gamma-glutamyl-peptidase activity			breast(1)|kidney(1)|large_intestine(1)|liver(1)|lung(6)|stomach(1)	11	Breast(64;0.0716)	all_cancers(86;0.189)|Lung NSC(129;0.0324)|all_lung(136;0.0593)|all_epithelial(80;0.131)			Folic Acid(DB00158)|L-Glutamic Acid(DB00142)	CGCAGCAATATAGTATCTTCC	0.308000													47	79					0	0	0.323286	0	0
SNX31	169166	broad.mit.edu	37	8	101601191	101601191	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:101601191G>A	ENST00000311812.2	-	11	1145	c.995C>T	c.(994-996)aCg>aTg	p.T332M	SNX31_ENST00000428383.2_Missense_Mutation_p.T233M|SNX31_ENST00000519521.1_5'UTR	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	332					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			GGGCCCATCCGTATCCAGCAG	0.423000													25	29					0	0	0.153744	0	0
STH	246744	broad.mit.edu	37	17	44076767	44076767	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:44076767A>T	ENST00000537309.1	+	1	152	c.122A>T	c.(121-123)cAg>cTg	p.Q41L	MAPT_ENST00000340799.5_Intron|MAPT_ENST00000262410.5_Intron|MAPT_ENST00000431008.3_Intron|MAPT_ENST00000347967.5_Intron|MAPT_ENST00000570299.1_Intron|MAPT_ENST00000344290.5_Intron|MAPT_ENST00000571987.1_Intron|MAPT_ENST00000535772.1_Intron|MAPT_ENST00000446361.3_Intron|MAPT_ENST00000351559.5_Intron|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000415613.2_Intron|MAPT_ENST00000420682.2_Intron|MAPT_ENST00000574436.1_Intron|MAPT_ENST00000576518.1_Intron	NM_001007532.2	NP_001007533.1	Q8IWL8	STH_HUMAN	saitohin	41						cytoplasm|nucleus				endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						TGGATGATTCAGGTTGCCAGA	0.527000													22	47					0	0	0.294199	0	0
HCG17	414778	broad.mit.edu	37	6	30231185	30231185	+	RNA	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:30231185A>C	ENST00000453558.1	-	0	126				HLA-L_ENST00000463348.1_RNA																							GCCCCTGCACACAGAAGTCTG	0.468000													12	135					0	0	0.119110	0	0
SVEP1	79987	broad.mit.edu	37	9	113341784	113341784	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:113341784G>T	ENST00000401783.2	-	1	376	c.40C>A	c.(40-42)Ctc>Atc	p.L14I	SVEP1_ENST00000374469.1_5'UTR|SVEP1_ENST00000374461.1_5'UTR|SVEP1_ENST00000302728.8_Missense_Mutation_p.L14I	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	14					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CCCGAAACGAGCGCCAGACCC	0.711000													4	2					0.184627	0.186433	0.184627	1	0
OR9I1	219954	broad.mit.edu	37	11	57886573	57886573	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:57886573A>T	ENST00000302610.1	-	1	343	c.344T>A	c.(343-345)cTg>cAg	p.L115Q	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	115					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				CATCACTGCCAGCAGAAAGCA	0.557000													49	102					0	0	0.323286	0	0
NET1	10276	broad.mit.edu	37	10	5496321	5496321	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:5496321G>T	ENST00000355029.4	+	9	1004	c.862G>T	c.(862-864)Gac>Tac	p.D288Y	NET1_ENST00000380359.3_Missense_Mutation_p.D234Y|NET1_ENST00000542715.1_Missense_Mutation_p.D107Y	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	288	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity			breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						AAGAGTCCAAGACTTCCTCCA	0.463000													24	97					4.26978e-12	5.07036e-12	0.279207	1	0
LRIF1	55791	broad.mit.edu	37	1	111494009	111494009	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:111494009T>C	ENST00000369763.4	-	2	1887	c.1497A>G	c.(1495-1497)agA>agG	p.R499R	LRIF1_ENST00000485275.2_Intron|RP11-96K19.2_ENST00000440689.1_RNA|LRIF1_ENST00000494675.1_Intron	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	499					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						CACTTCCTTTTCTAGCATAAA	0.393000													91	252					0	0	0.323286	0	0
CALN1	83698	broad.mit.edu	37	7	71488712	71488712	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:71488712C>A	ENST00000395275.2	-	5	819	c.431G>T	c.(430-432)gGc>gTc	p.G144V	CALN1_ENST00000395276.2_Missense_Mutation_p.G102V|CALN1_ENST00000431984.1_Missense_Mutation_p.G102V|CALN1_ENST00000405452.2_Missense_Mutation_p.G102V|CALN1_ENST00000329008.5_Missense_Mutation_p.G102V|CALN1_ENST00000412588.1_Missense_Mutation_p.G144V	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	102						Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CAGTTTGGGGCCAAGAATGGT	0.438000													29	157					2.05212e-20	2.76202e-20	0.225048	1	0
TRIML1	339976	broad.mit.edu	37	4	189065004	189065004	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:189065004G>T	ENST00000332517.3	+	4	888	c.748G>T	c.(748-750)Gcc>Tcc	p.A250S	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	250					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGTGAGAGGAGCCCTGGAAAG	0.478000													25	70					9.39395e-14	1.1472e-13	0.116897	1	0
ASTN1	460	broad.mit.edu	37	1	176857284	176857284	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:176857284G>T	ENST00000367654.2	-	18	3034	c.3021C>A	c.(3019-3021)atC>atA	p.I1007I	ASTN1_ENST00000424564.2_Silent_p.I999I|ASTN1_ENST00000361833.2_Silent_p.I999I|ASTN1_ENST00000367657.3_Silent_p.I999I			O14525	ASTN1_HUMAN	astrotactin 1	1007					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						ACCAGTCCTCGATGACATCTC	0.532000													33	99					9.85521e-28	1.43834e-27	0.235728	1	0
SEMA7A	8482	broad.mit.edu	37	15	74704250	74704250	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:74704250C>A	ENST00000261918.4	-	11	1946	c.1398G>T	c.(1396-1398)caG>caT	p.Q466H	SEMA7A_ENST00000542748.1_Missense_Mutation_p.Q301H|SEMA7A_ENST00000543145.2_Missense_Mutation_p.Q452H	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	466	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						GCGACATGGTCTGGATGGCAG	0.617000													18	26					5.45024e-15	6.79251e-15	0.279207	1	0
DPPA5	340168	broad.mit.edu	37	6	74063590	74063590	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:74063590T>A	ENST00000370370.3	-	2	347	c.278A>T	c.(277-279)cAg>cTg	p.Q93L		NM_001025290.2	NP_001020461.1	A6NC42	DPPA5_HUMAN	developmental pluripotency associated 5	93					multicellular organismal development	cytoplasm	RNA binding			NS(1)|endometrium(1)|lung(5)	7						CTCCTGGCGCTGGCGGTGCCA	0.632000													23	30					0	0	0.324025	0	0
KDR	3791	broad.mit.edu	37	4	55971034	55971034	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:55971034G>A	ENST00000263923.4	-	13	2058	c.1763C>T	c.(1762-1764)cCa>cTa	p.P588L		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	588	Ig-like C2-type 6.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CAGAGGCTGTGGGCCAAGCTT	0.498000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			62	165					0	0	0.323286	0	0
MT-CO1	4512	broad.mit.edu	37	MT	5951	5951	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrM:5951A>G	ENST00000361624.2	+	1	48	c.48A>G	c.(46-48)ggA>ggG	p.16_16insG						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						AAAGACATTGGAACACTATAC	0.493000													9	98					0	0	0.189662	0	0
FLG2	388698	broad.mit.edu	37	1	152323426	152323426	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152323426G>T	ENST00000388718.5	-	3	6908	c.6836C>A	c.(6835-6837)gCt>gAt	p.A2279D	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2279							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGAGATCCAGCTTGGCCCTG	0.507000													159	325					1.78104e-58	3.10405e-58	0.323286	1	0
ZNF804A	91752	broad.mit.edu	37	2	185802946	185802946	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:185802946G>T	ENST00000302277.6	+	4	3417	c.2823G>T	c.(2821-2823)gaG>gaT	p.E941D		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	941						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAAGAAGTGAGAATATAAATC	0.378000													132	144					7.82854e-59	1.36592e-58	0.323286	1	0
OR5B21	219968	broad.mit.edu	37	11	58275240	58275240	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:58275240C>A	ENST00000360374.2	-	1	338	c.339G>T	c.(337-339)ctG>ctT	p.L113L		NM_001005218.1	NP_001005218.1	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B, member 21	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCATGGAGGCCAGGAGGTAGC	0.552000													80	219					8.78217e-53	1.49771e-52	0.323286	1	0
ZC3H11A	9877	broad.mit.edu	37	1	203809456	203809456	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:203809456G>T	ENST00000545588.1	+	11	4823	c.996G>T	c.(994-996)aaG>aaT	p.K332N	ZC3H11A_ENST00000332127.4_Missense_Mutation_p.K332N|ZC3H11A_ENST00000367210.1_Missense_Mutation_p.K332N|ZC3H11A_ENST00000367212.3_Missense_Mutation_p.K332N|ZC3H11A_ENST00000367214.1_Missense_Mutation_p.K332N	NM_001271675.1	NP_001258604.1	O75152	ZC11A_HUMAN	zinc finger CCCH-type containing 11A	332							nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32	all_cancers(21;0.0904)|all_epithelial(62;0.234)		BRCA - Breast invasive adenocarcinoma(75;0.109)			AGTCTCTTAAGGAGCGATTAG	0.368000													128	57					1.49586e-50	2.52463e-50	0.323286	1	0
ZNF831	128611	broad.mit.edu	37	20	57769045	57769045	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:57769045A>G	ENST00000371030.2	+	1	2971	c.2971A>G	c.(2971-2973)Agc>Ggc	p.S991G		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	991						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					TCTTTCTCCCAGCCCAGCCTC	0.642000													5	54					0	0	0.217242	0	0
GALNT18	374378	broad.mit.edu	37	11	11362513	11362513	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:11362513G>A	ENST00000227756.4	-	7	1542	c.1131C>T	c.(1129-1131)tgC>tgT	p.C377C		NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		CAATCCGTGAGCAGGGCAGGA	0.617000													420	38					0	0	0.323286	0	0
AKAP3	10566	broad.mit.edu	37	12	4737038	4737038	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:4737038C>T	ENST00000545990.2	-	5	1554	c.1030G>A	c.(1030-1032)Gtc>Atc	p.V344I	AKAP3_ENST00000228850.1_Missense_Mutation_p.V344I	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	344					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						GTCCCTGTGACGCTGTGGAGA	0.493000													52	196					0	0	0.323286	0	0
SLC18A3	6572	broad.mit.edu	37	10	50819662	50819662	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:50819662C>A	ENST00000374115.3	+	1	1316	c.876C>A	c.(874-876)gcC>gcA	p.A292A	CHAT_ENST00000339797.1_Intron	NM_003055.2	NP_003046.2	Q16572	VACHT_HUMAN	solute carrier family 18 (vesicular acetylcholine transporter), member 3	292					neurotransmitter secretion	clathrin sculpted acetylcholine transport vesicle membrane|integral to plasma membrane|membrane fraction	acetylcholine transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	43						CCTACATTGCCGTGGTGGCCG	0.647000													23	37					1.56442e-22	2.16876e-22	0.163468	1	0
RASSF2	9770	broad.mit.edu	37	20	4768388	4768388	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:4768388A>C	ENST00000379400.3	-	10	899	c.704T>G	c.(703-705)cTg>cGg	p.L235R	RASSF2_ENST00000379376.2_Missense_Mutation_p.L235R|RASSF2_ENST00000478553.1_Intron	NM_014737.2	NP_055552.1	P50749	RASF2_HUMAN	Ras association (RalGDS/AF-6) domain family member 2	235	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|pancreas(2)|prostate(2)|skin(2)	34						GGTGGCCTTCAGCTTCTGTTT	0.537000													12	18					0	0	0.219247	0	0
OR2W3	343171	broad.mit.edu	37	1	248059009	248059009	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248059009G>T	ENST00000537741.1	+	3	378	c.121G>T	c.(121-123)Ggc>Tgc	p.G41C	OR2W3_ENST00000360358.3_Missense_Mutation_p.G41C			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GACCCTCGTAGGCAACACCAC	0.572000													120	353					1.21591e-56	2.10609e-56	0.323286	1	0
SLC17A6	57084	broad.mit.edu	37	11	22398157	22398157	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:22398157G>T	ENST00000263160.3	+	11	1789	c.1352G>T	c.(1351-1353)gGt>gTt	p.G451V		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	451					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						ATTTCGAATGGTGTTGGCACA	0.388000													75	43					4.18771e-30	6.25934e-30	0.323286	1	0
TULP4	56995	broad.mit.edu	37	6	158873181	158873181	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:158873181A>G	ENST00000367097.3	+	5	2097	c.740A>G	c.(739-741)tAt>tGt	p.Y247C	TULP4_ENST00000367094.2_Missense_Mutation_p.Y247C	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	247					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CCGGCAGCATATCCCATCCCA	0.527000													40	127					0	0	0.312237	0	0
GUCA2B	2981	broad.mit.edu	37	1	42620422	42620422	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:42620422C>T	ENST00000372581.1	+	2	192	c.162C>T	c.(160-162)agC>agT	p.S54S		NM_007102.2	NP_009033.1	Q16661	GUC2B_HUMAN	guanylate cyclase activator 2B (uroguanylin)	54					excretion	extracellular region	calcium sensitive guanylate cyclase activator activity			breast(1)|large_intestine(2)	3	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GGGCACCCAGCCCCCGCCTGC	0.647000													11	90					0	0	0.080935	0	0
PPFIA2	8499	broad.mit.edu	37	12	82147948	82147948	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:82147948C>T	ENST00000550584.2	-	2	348	c.53G>A	c.(52-54)aGg>aAg	p.R18K	PPFIA2_ENST00000552948.1_Missense_Mutation_p.R18K|PPFIA2_ENST00000333447.7_Missense_Mutation_p.R18K|PPFIA2_ENST00000549325.1_Missense_Mutation_p.R18K|PPFIA2_ENST00000548586.1_Missense_Mutation_p.R18K|PPFIA2_ENST00000549396.1_Missense_Mutation_p.R18K	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	277										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TTGGGACCCCCTTTGGCTCAT	0.468000													28	31					0	0	0.235728	0	0
OR6C76	390326	broad.mit.edu	37	12	55820397	55820397	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55820397T>C	ENST00000328314.3	+	1	360	c.360T>C	c.(358-360)taT>taC	p.Y120Y		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						ATGATTGCTATGTGGCTATAT	0.403000													66	168					0	0	0.323286	0	0
CPN1	1369	broad.mit.edu	37	10	101808580	101808580	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:101808580C>A	ENST00000370418.3	-	8	1416	c.1165G>T	c.(1165-1167)Gcc>Tcc	p.A389S		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	389					proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		GGTGCTGTGGCACTAACAGTG	0.493000													151	12					1.04827e-66	1.8562e-66	0.323286	1	0
FURIN	5045	broad.mit.edu	37	15	91419749	91419749	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:91419749G>T	ENST00000268171.3	+	4	613	c.334G>T	c.(334-336)Gag>Tag	p.E112*		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	112					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			CGTGTACCAGGAGCCCACAGA	0.607000													9	17					7.48243e-07	8.1252e-07	0.058154	1	0
CROCCP2	84809	broad.mit.edu	37	1	16956821	16956821	+	RNA	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:16956821C>G	ENST00000412962.1	-	0	294																											TCCTATGTGCCCTCACCACCC	0.647000													3	23					0	0	0.115264	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28296937	28296937	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:28296937T>A	ENST00000284987.5	-	8	2349	c.2228A>T	c.(2227-2229)aAg>aTg	p.K743M	AP001601.2_ENST00000426771.1_RNA	NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	743	Spacer.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						AGTGTAACCCTTACTGGAAGT	0.413000													59	82					0	0	0.323286	0	0
RIMS3	9783	broad.mit.edu	37	1	41094586	41094586	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:41094586C>T	ENST00000372684.3	-	7	1079	c.610G>A	c.(610-612)Gcc>Acc	p.A204T	RIMS3_ENST00000372683.1_Missense_Mutation_p.A204T	NM_014747.2	NP_055562.2	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	204	C2.				neurotransmitter transport	cell junction|synapse				NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			GCCAAGCAGGCCCCATTCTCC	0.557000													59	127					0	0	0.323286	0	0
SLC35B3	51000	broad.mit.edu	37	6	8435681	8435681	+	Translation_Start_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:8435681C>A	ENST00000379660.4	-	0	35				SLC35B3_ENST00000426876.1_De_novo_Start_OutOfFrame|SLC35B3_ENST00000339306.5_De_novo_Start_InFrame	NM_001142540.1|NM_001142541.1|NM_015948.3	NP_001136012.1|NP_001136013.1|NP_057032.2	Q9H1N7	S35B3_HUMAN	solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3						transmembrane transport	Golgi membrane|integral to membrane				breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(1)|prostate(1)	15	Ovarian(93;0.0569)					cctcctcttcctcctcctcct	0.677000													4	4					0.00909568	0.00927843	0.150653	1	0
CYP4B1	1580	broad.mit.edu	37	1	47284381	47284381	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:47284381T>C	ENST00000271153.4	+	12	1467	c.1431T>C	c.(1429-1431)tcT>tcC	p.S477S	CYP4B1_ENST00000452782.2_Silent_p.S315S|CYP4B1_ENST00000371923.4_Silent_p.S478S|CYP4B1_ENST00000371919.4_Silent_p.S463S			P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B, polypeptide 1	477					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	36	Acute lymphoblastic leukemia(166;0.155)					TTGAGTTCTCTCTGGACCCCT	0.572000													75	132					0	0	0.323286	0	0
GFI1B	8328	broad.mit.edu	37	9	135862731	135862731	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:135862731C>A	ENST00000339463.3	+	7	982	c.163C>A	c.(163-165)Ctg>Atg	p.L55M	GFI1B_ENST00000372123.1_Missense_Mutation_p.L55M|GFI1B_ENST00000372122.1_Missense_Mutation_p.L55M|GFI1B_ENST00000372124.1_Missense_Mutation_p.L55M|GFI1B_ENST00000534944.1_Missense_Mutation_p.L55M|GFI1B_ENST00000450530.1_Missense_Mutation_p.L55M			Q5VTD9	GFI1B_HUMAN	growth factor independent 1B transcription repressor	55					cell proliferation|chromatin modification|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	21				OV - Ovarian serous cystadenocarcinoma(145;9.04e-07)|Epithelial(140;1.17e-05)		AAACCAGTGCCTGGACTGGAC	0.597000													31	22					1.74807e-11	2.05612e-11	0.153744	1	0
PCDH11X	27328	broad.mit.edu	37	X	91133250	91133250	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:91133250C>A	ENST00000373094.1	+	2	2856	c.2011C>A	c.(2011-2013)Cca>Aca	p.P671T	PCDH11X_ENST00000361724.1_Missense_Mutation_p.P671T|PCDH11X_ENST00000373097.1_Missense_Mutation_p.P671T|PCDH11X_ENST00000373088.1_Missense_Mutation_p.P671T|PCDH11X_ENST00000361655.2_Missense_Mutation_p.P671T|PCDH11X_ENST00000395337.2_Missense_Mutation_p.P671T|PCDH11X_ENST00000298274.8_Missense_Mutation_p.P671T|PCDH11X_ENST00000504220.1_Missense_Mutation_p.P671T|PCDH11X_ENST00000406881.1_Missense_Mutation_p.P671T	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	671	Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TGACAACAAACCAGTTTTCAT	0.408000													49	64					3.95532e-38	6.30125e-38	0.323286	1	0
ATP8A1	10396	broad.mit.edu	37	4	42580345	42580345	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:42580345G>A	ENST00000381668.5	-	12	1291	c.1060C>T	c.(1060-1062)Ctc>Ttc	p.L354F	ATP8A1_ENST00000264449.10_Missense_Mutation_p.L354F	NM_006095.2	NP_006086.1	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1	354					ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	51					Phosphatidylserine(DB00144)	ATAGGAATGAGATTGTTGAAA	0.358000													46	60					0	0	0.323286	0	0
PARP8	79668	broad.mit.edu	37	5	50117170	50117170	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:50117170A>T	ENST00000281631.5	+	16	1950	c.1792A>T	c.(1792-1794)Agg>Tgg	p.R598W	PARP8_ENST00000503750.2_Intron|PARP8_ENST00000514067.2_Intron|PARP8_ENST00000505554.1_Missense_Mutation_p.R577W|PARP8_ENST00000505697.2_Missense_Mutation_p.R598W|PARP8_ENST00000514342.2_Intron|PARP8_ENST00000511363.2_3'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	598						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				CTTCAACCCCAGGGTAAGTTG	0.388000													42	70					0	0	0.323286	0	0
HECW1	23072	broad.mit.edu	37	7	43594353	43594353	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:43594353G>A	ENST00000395891.1	+	29	5278	c.4673G>A	c.(4672-4674)tGc>tAc	p.C1558Y	HECW1_ENST00000453890.1_Missense_Mutation_p.C1524Y	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1558	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CGGCGCTTCTGCATAGAGAAA	0.542000													33	23					0	0	0.173368	0	0
TTLL6	284076	broad.mit.edu	37	17	46862326	46862326	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:46862326C>G	ENST00000393382.3	-	13	2140	c.1999G>C	c.(1999-2001)Gcc>Ccc	p.A667P	TTLL6_ENST00000433608.2_Missense_Mutation_p.A360P	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	619						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GCAGACTTGGCCTCCTTGATG	0.532000													68	53					0	0	0.323286	0	0
PASK	23178	broad.mit.edu	37	2	242076536	242076536	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:242076536C>A	ENST00000403638.3	-	7	1111	c.1020G>T	c.(1018-1020)tgG>tgT	p.W340C	PASK_ENST00000358649.4_Missense_Mutation_p.W340C|PASK_ENST00000539818.1_Missense_Mutation_p.W124C|PASK_ENST00000405260.1_Missense_Mutation_p.W340C|PASK_ENST00000234040.4_Missense_Mutation_p.W340C|PASK_ENST00000544142.1_Missense_Mutation_p.W154C	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	340	PAS 2.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		TGCAGAACACCCAGACAGATG	0.607000													16	65					1.67942e-08	1.86622e-08	0.175082	1	0
CTH	1491	broad.mit.edu	37	1	70904437	70904437	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:70904437G>T	ENST00000411986.2	+	10	1221	c.1023G>T	c.(1021-1023)ctG>ctT	p.L341L	CTH_ENST00000346806.2_Silent_p.L329L|CTH_ENST00000370938.3_Silent_p.L373L	NM_001190463.1	NP_001177392.1	P32929	CGL_HUMAN	cystathionase (cystathionine gamma-lyase)	373					cysteine biosynthetic process|hydrogen sulfide biosynthetic process|protein homotetramerization|protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine	cytoplasm|nucleus	cystathionine gamma-lyase activity|L-cysteine desulfhydrase activity|pyridoxal phosphate binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	18					L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	GTGACACACTGATTCGACTTT	0.408000													36	100					2.32173e-10	2.66806e-10	0.214465	1	0
MPP4	58538	broad.mit.edu	37	2	202547586	202547586	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:202547586C>A	ENST00000409474.3	-	8	835	c.628G>T	c.(628-630)Gga>Tga	p.G210*	MPP4_ENST00000409143.1_Nonsense_Mutation_p.G183*|MPP4_ENST00000359962.5_Nonsense_Mutation_p.G210*|MPP4_ENST00000447335.2_Nonsense_Mutation_p.G210*|MPP4_ENST00000315506.7_Nonsense_Mutation_p.G210*|MPP4_ENST00000396886.3_Nonsense_Mutation_p.G166*|MPP4_ENST00000428900.2_Nonsense_Mutation_p.G210*	NM_033066.2	NP_149055.1	Q96JB8	MPP4_HUMAN	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	210	PDZ.					cytoplasm	protein binding			kidney(1)|lung(11)	12						GGGTCCAGTCCCTCAACTGAA	0.408000													64	111					5.39075e-54	9.24939e-54	0.323286	1	0
WDTC1	23038	broad.mit.edu	37	1	27627883	27627883	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:27627883G>T	ENST00000319394.3	+	13	1934	c.1399G>T	c.(1399-1401)Gcc>Tcc	p.A467S	WDTC1_ENST00000361771.3_Missense_Mutation_p.A466S	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	467							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		TCCGGAGCAGGCCCACAGCAG	0.572000											OREG0013280	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	83					8.88839e-20	1.18295e-19	0.153744	1	0
DCHS1	8642	broad.mit.edu	37	11	6653761	6653761	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:6653761A>T	ENST00000299441.3	-	6	3393	c.2982T>A	c.(2980-2982)cgT>cgA	p.R994R	RP11-732A19.6_ENST00000526633.1_RNA	NM_003737.2	NP_003728.1	Q96JQ0	PCD16_HUMAN	dachsous cadherin-related 1	994	Cadherin 9.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(16)|liver(1)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	103		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGCCAGCCCACGGGTTCCCA	0.657000													17	2					0	0	0.249174	0	0
SHANK2	22941	broad.mit.edu	37	11	70332419	70332419	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:70332419C>A	ENST00000338508.4	-	32	3981	c.3982G>T	c.(3982-3984)Gcc>Tcc	p.A1328S	SHANK2_ENST00000409161.1_Missense_Mutation_p.A731S|SHANK2_ENST00000449833.2_Missense_Mutation_p.A732S|SHANK2_ENST00000423696.2_Missense_Mutation_p.A948S			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	948					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TCCTGCAGGGCGTTGTCCAGC	0.572000													16	26					4.75885e-15	5.93802e-15	0.160694	1	0
POTEG	404785	broad.mit.edu	37	14	19563531	19563531	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:19563531C>A	ENST00000409832.3	+	5	1097	c.1045C>A	c.(1045-1047)Cat>Aat	p.H349N	CTD-2311B13.5_ENST00000548748.1_lincRNA	NM_001005356.2	NP_001005356.1	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	349				H -> R (in Ref. 1; AAS58868/AAS58871).				p.H349N(1)		cervix(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(31)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	47						TGTTTCTAGTCATCATAATGT	0.353000													67	594					2.43199e-30	3.64563e-30	0.323286	1	0
MICAL1	64780	broad.mit.edu	37	6	109771521	109771521	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:109771521C>A	ENST00000368952.4	-	8	1520	c.1230G>T	c.(1228-1230)gtG>gtT	p.V410V	MICAL1_ENST00000358807.3_Silent_p.V391V|MICAL1_ENST00000358577.3_Intron			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	391					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		GGCAGTCCCCCACCAGTCCCA	0.597000													14	45					0.014323	0.0146059	0.249174	1	0
C6orf165	154313	broad.mit.edu	37	6	88136356	88136356	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:88136356A>T	ENST00000507897.1	+	8	1036	c.953A>T	c.(952-954)cAa>cTa	p.Q318L	C6ORF165_ENST00000369562.4_Missense_Mutation_p.Q318L			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	318										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		CCAACATCACAAGTCTTTGTA	0.343000													20	32					0	0	0.219247	0	0
NRG3	10718	broad.mit.edu	37	10	84744866	84744866	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:84744866T>G	ENST00000372142.2	+	11	1279	c.1005T>G	c.(1003-1005)agT>agG	p.S335R	NRG3_ENST00000404576.2_Missense_Mutation_p.S336R|NRG3_ENST00000556918.1_Missense_Mutation_p.S362R|NRG3_ENST00000545131.1_Missense_Mutation_p.S182R|NRG3_ENST00000537893.1_Missense_Mutation_p.S182R|NRG3_ENST00000372141.2_Missense_Mutation_p.S532R|NRG3_ENST00000404547.1_Missense_Mutation_p.S556R	NM_001165973.1	NP_001159445.1	P56975	NRG3_HUMAN	neuregulin 3	556					regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		ATTCATCCAGTGGTTTAAAAA	0.398000													265	28					0	0	0.323286	0	0
B3GALT5	10317	broad.mit.edu	37	21	41033394	41033394	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:41033394G>A	ENST00000380620.3	+	5	1500	c.908G>A	c.(907-909)cGg>cAg	p.R303Q	B3GALT5_ENST00000380618.1_Missense_Mutation_p.R303Q|B3GALT5_ENST00000343118.4_Missense_Mutation_p.R303Q|AF064860.5_ENST00000416555.1_RNA|B3GALT5_ENST00000398714.2_Missense_Mutation_p.R303Q			Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5	303					protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	16		Prostate(19;2.55e-06)				GAGAATTCCCGGGGGGAAGAT	0.552000													114	125					0	0	0.323286	0	0
LAMA5	3911	broad.mit.edu	37	20	60889747	60889747	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:60889747C>A	ENST00000252999.3	-	61	8297	c.8231G>T	c.(8230-8232)gGg>gTg	p.G2744V		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	2744	Laminin G-like 1.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGCTGCACCCCTGAGCGCCC	0.652000													5	6					0.0215528	0.0219352	0.217242	1	0
MYO1D	4642	broad.mit.edu	37	17	31087344	31087344	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:31087344T>C	ENST00000318217.5	-	10	1564	c.1260A>G	c.(1258-1260)caA>caG	p.Q420Q	MYO1D_ENST00000584232.1_5'UTR|MYO1D_ENST00000579584.1_Silent_p.Q420Q|MYO1D_ENST00000394649.4_Silent_p.Q332Q|MYO1D_ENST00000583621.1_Silent_p.Q420Q	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	420	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			GGTATTCCTCTTGTTCTTGCT	0.363000													316	662					0	0	0.323286	0	0
BARHL2	343472	broad.mit.edu	37	1	91182574	91182574	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:91182574G>T	ENST00000370445.4	-	1	220	c.179C>A	c.(178-180)aCg>aAg	p.T60K		NM_020063.1	NP_064447.1	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	60						nucleus	sequence-specific DNA binding			cervix(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		AGAAGGCGCCGTCCCTACGGT	0.602000													31	70					6.00712e-18	7.79391e-18	0.163468	1	0
NPAS4	266743	broad.mit.edu	37	11	66190613	66190613	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66190613T>G	ENST00000311034.2	+	5	894	c.718T>G	c.(718-720)Ttt>Gtt	p.F240V		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	240	PAS 2.				transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CTACCTGGGCTTTGAGCGCAG	0.537000													5	16					0	0	0.248553	0	0
ZNF706	51123	broad.mit.edu	37	8	102212243	102212243	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:102212243T>C	ENST00000520347.1	-	3	3174	c.218A>G	c.(217-219)gAt>gGt	p.D73G	ZNF706_ENST00000519882.1_Missense_Mutation_p.D73G|ZNF706_ENST00000311212.4_Missense_Mutation_p.D73G|ZNF706_ENST00000517844.1_Missense_Mutation_p.D73G|ZNF706_ENST00000518336.1_Missense_Mutation_p.D73G|ZNF706_ENST00000521272.1_Missense_Mutation_p.D73G|ZNF706_ENST00000520984.1_Missense_Mutation_p.D73G|ZNF706_ENST00000519744.1_Intron			Q9Y5V0	ZN706_HUMAN	zinc finger protein 706	73						intracellular	zinc ion binding			large_intestine(1)|ovary(2)	3	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			TGCCTGAACATCAGCTAATTC	0.393000													29	46					0	0	0.173368	0	0
SIGLEC7	27036	broad.mit.edu	37	19	51647734	51647734	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51647734T>A	ENST00000317643.6	+	2	574	c.505T>A	c.(505-507)Tct>Act	p.S169T	SIGLEC7_ENST00000600577.1_Intron|SIGLEC7_ENST00000305628.7_Intron	NM_014385.2	NP_055200.1	Q9Y286	SIGL7_HUMAN	sialic acid binding Ig-like lectin 7	169	Ig-like C2-type 1.				cell adhesion	integral to plasma membrane	receptor activity|sugar binding			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(11)|skin(2)|stomach(1)	29		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000836)|OV - Ovarian serous cystadenocarcinoma(262;0.00297)		TCTGACCTGCTCTGTGCCCTG	0.632000													92	214					0	0	0.323286	0	0
EIF3H	8667	broad.mit.edu	37	8	117671153	117671153	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:117671153C>G	ENST00000521861.1	-	3	379	c.356G>C	c.(355-357)tGg>tCg	p.W119S	EIF3H_ENST00000276682.4_Missense_Mutation_p.W133S	NM_003756.2	NP_003747.1	O15372	EIF3H_HUMAN	eukaryotic translation initiation factor 3, subunit H	119	MPN.				regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			large_intestine(2)|lung(10)|skin(1)	13	all_cancers(13;3.98e-22)|Lung NSC(37;0.000183)|Ovarian(258;0.0172)					GGACTGATACCAGCCCACGTG	0.438000													80	80					0	0	0.323286	0	0
SMR3B	10879	broad.mit.edu	37	4	71255442	71255442	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:71255442A>C	ENST00000304915.3	+	3	266	c.117A>C	c.(115-117)caA>caC	p.Q39H	SMR3B_ENST00000504825.1_Missense_Mutation_p.Q39H	NM_006685.3	NP_006676.1			submaxillary gland androgen regulated protein 3B											large_intestine(2)|lung(3)|skin(2)	7		all_hematologic(202;0.196)				CTCCTCCTCAACCTTTTGGCC	0.527000													23	89					0	0	0.294199	0	0
NPAS4	266743	broad.mit.edu	37	11	66188689	66188689	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66188689G>T	ENST00000311034.2	+	1	215	c.39G>T	c.(37-39)cgG>cgT	p.R13R		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	13					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						AGGCGCGCCGGGACCAGATCA	0.692000													24	17					5.35356e-11	6.23307e-11	0.264190	1	0
FUT9	10690	broad.mit.edu	37	6	96651472	96651472	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:96651472C>A	ENST00000302103.5	+	3	767	c.441C>A	c.(439-441)ggC>ggA	p.G147G		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	147					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		AAAAGAGTGGCATTGAGCACT	0.458000													35	72					6.53348e-20	8.72915e-20	0.193644	1	0
OR5D13	390142	broad.mit.edu	37	11	55541613	55541613	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55541613A>C	ENST00000361760.1	+	1	700	c.700A>C	c.(700-702)Agt>Cgt	p.S234R		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	234					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				GCGATCTGCAAGTGGGCGCCA	0.408000													17	171					0	0	0.219247	0	0
SLC35F6	54978	broad.mit.edu	37	2	27001345	27001345	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:27001345G>T	ENST00000344420.5	+	6	1144	c.1082G>T	c.(1081-1083)gGt>gTt	p.G361V	CENPA_ENST00000475662.1_Intron|SLC35F6_ENST00000416475.2_Missense_Mutation_p.G278V	NM_017877.3	NP_060347.2			solute carrier family 35, member F6																		AGACTGCTGGGTGGCACCCGC	0.652000													24	19					1.10923e-09	1.25789e-09	0.264190	1	0
LRRC7	57554	broad.mit.edu	37	1	70446073	70446073	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:70446073G>C	ENST00000310961.5	+	10	1042	c.624G>C	c.(622-624)ctG>ctC	p.L208L	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Silent_p.L203L			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	203						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CTGAAGTTCTGGATCAAATAC	0.333000													95	229					0	0	0.323286	0	0
SYCP2	10388	broad.mit.edu	37	20	58443526	58443526	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:58443526T>A	ENST00000357552.3	-	38	4155	c.3930A>T	c.(3928-3930)gcA>gcT	p.A1310A	SYCP2_ENST00000371001.2_Silent_p.A1310A			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	1310					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			GAAGCAAGTTTGCTCTCCTTT	0.358000													129	152					0	0	0.323286	0	0
RB1	5925	broad.mit.edu	37	13	48941739	48941739	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:48941739G>T	ENST00000267163.4	+	10	1187	c.1049_splice	c.e10+1	p.S350_splice		NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1	350					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(7)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCTATAGACAGGTATTGCACA	0.284000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			44	17					3.05275e-18	3.97911e-18	0.312237	1	0
SCN7A	6332	broad.mit.edu	37	2	167297982	167297982	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:167297982C>G	ENST00000409855.1	-	14	2207	c.2081G>C	c.(2080-2082)tGg>tCg	p.W694S		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	694					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CATACAGTCCCACAAGGTCTC	0.433000													112	141					0	0	0.323286	0	0
OR11H6	122748	broad.mit.edu	37	14	20691979	20691979	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20691979T>C	ENST00000315519.2	+	1	189	c.111T>C	c.(109-111)ggT>ggC	p.G37G		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		GTTTCCATGGTCAAAGGGAGA	0.438000													31	230					0	0	0.183431	0	0
C1orf222	339457	broad.mit.edu	37	1	1920383	1920383	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:1920383C>A	ENST00000434971.2	-	3	129	c.97G>T	c.(97-99)Gac>Tac	p.D33Y				Q69YW0	CA222_HUMAN	chromosome 1 open reading frame 222	0										breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)	11	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CATTTGATGTCAAACTCCGGA	0.463000													8	23					2.80697e-09	3.15772e-09	0.080935	1	0
TFF2	7032	broad.mit.edu	37	21	43771095	43771095	+	Translation_Start_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:43771095T>A	ENST00000291526.4	-	0	142				TFF2_ENST00000475297.1_5'UTR	NM_005423.4	NP_005414.1	Q03403	TFF2_HUMAN	trefoil factor 2						digestion	extracellular region				large_intestine(1)|pancreas(1)|urinary_tract(1)	3						CCAGGGTGGCTTGCAGAATGC	0.602000													17	13					0	0	0.160694	0	0
NMUR2	56923	broad.mit.edu	37	5	151784152	151784152	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:151784152C>G	ENST00000255262.3	-	1	688	c.523G>C	c.(523-525)Gtg>Ctg	p.V175L	NMUR2_ENST00000518933.1_Intron	NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	175					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			GAGAAGAGCACGGAGAAGCCC	0.632000													35	60					0	0	0.214465	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905636	144905636	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:144905636G>T	ENST00000370490.1	+	1	5948	c.1693G>T	c.(1693-1695)Gca>Tca	p.A565S	SLITRK2_ENST00000428560.2_Missense_Mutation_p.A565S|SLITRK2_ENST00000434188.2_Missense_Mutation_p.A565S|SLITRK2_ENST00000413937.2_Missense_Mutation_p.A565S|SLITRK2_ENST00000447897.2_Missense_Mutation_p.A565S			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	565	LRRCT 2.					integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TGCTAAGCATGCAGGGGAGAT	0.478000													37	5					1.57019e-19	2.08439e-19	0.257332	1	0
ESCO1	114799	broad.mit.edu	37	18	19116137	19116137	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:19116137T>C	ENST00000269214.5	-	10	2990	c.2053A>G	c.(2053-2055)Att>Gtt	p.I685V		NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1	685					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						ATCTCTCTAATCTCGTCAACC	0.303000													56	21					0	0	0.323286	0	0
PRUNE2	158471	broad.mit.edu	37	9	79323987	79323987	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:79323987T>C	ENST00000428286.1	-	8	3326	c.2126A>G	c.(2125-2127)gAg>gGg	p.E709G	PRUNE2_ENST00000376718.3_Missense_Mutation_p.E1068G			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1068					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GACGTCATCCTCCATGGAGAT	0.453000													50	14					0	0	0.323286	0	0
CEP63	80254	broad.mit.edu	37	3	134278007	134278007	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:134278007G>A	ENST00000337090.3	+	14	1862	c.1689G>A	c.(1687-1689)caG>caA	p.Q563Q	CEP63_ENST00000332047.5_Intron|CEP63_ENST00000606977.1_Silent_p.Q563Q|CEP63_ENST00000513612.2_Silent_p.Q563Q|CEP63_ENST00000383229.3_Intron|CEP63_ENST00000354446.3_Intron			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	563					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						CCCATGGCCAGCACAGACATG	0.388000													5	419					0	0	0.184627	0	0
KIAA1549	57670	broad.mit.edu	37	7	138603939	138603939	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:138603939C>G	ENST00000440172.1	-	2	481	c.433G>C	c.(433-435)Gtg>Ctg	p.V145L	KIAA1549_ENST00000422774.1_Missense_Mutation_p.V145L|KIAA1549_ENST00000242365.4_Missense_Mutation_p.V95L	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	145						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TTACTCGTCACTGACACGTAA	0.463000			O	BRAF	pilocytic astrocytoma								233	601					0	0	0.323286	0	0
PRMT7	54496	broad.mit.edu	37	16	68349919	68349919	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:68349919G>C	ENST00000339507.5	+	3	867	c.37G>C	c.(37-39)Ggg>Cgg	p.G13R	PRMT7_ENST00000564441.1_Intron|PRMT7_ENST00000441236.1_Missense_Mutation_p.G13R|PRMT7_ENST00000348497.4_Missense_Mutation_p.G13R|PRMT7_ENST00000449359.3_Missense_Mutation_p.G13R			Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	13					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(10)|pancreas(1)|urinary_tract(1)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		TCCGACCACGGGGTCTGTGGA	0.552000													5	20					0	0	0.058154	0	0
ROBO2	6092	broad.mit.edu	37	3	77651625	77651625	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:77651625A>T	ENST00000461745.1	+	20	4019	c.3119A>T	c.(3118-3120)cAg>cTg	p.Q1040L	ROBO2_ENST00000332191.8_Missense_Mutation_p.Q1040L|ROBO2_ENST00000487694.3_Missense_Mutation_p.Q1056L	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1040					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CTACCTGATCAGAACAAAGGT	0.378000													74	44					0	0	0.323286	0	0
PTPRD	5789	broad.mit.edu	37	9	8484156	8484156	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:8484156C>A	ENST00000381196.4	-	27	3919	c.3376G>T	c.(3376-3378)Gtg>Ttg	p.V1126L	PTPRD_ENST00000397606.3_Missense_Mutation_p.V705L|PTPRD_ENST00000397611.3_Missense_Mutation_p.V712L|PTPRD_ENST00000397617.3_Missense_Mutation_p.V705L|PTPRD_ENST00000540109.1_Missense_Mutation_p.V1126L|PTPRD_ENST00000360074.4_Missense_Mutation_p.V1113L|PTPRD_ENST00000537002.1_Missense_Mutation_p.V712L|PTPRD_ENST00000486161.1_Missense_Mutation_p.V715L|PTPRD_ENST00000356435.5_Missense_Mutation_p.V1126L|PTPRD_ENST00000355233.5_Missense_Mutation_p.V715L|PTPRD_ENST00000358503.5_Missense_Mutation_p.V1104L	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1126					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGCAGTTGCACAGTAATCATG	0.438000										TSP Lung(15;0.13)			83	90					1.11079e-38	1.77784e-38	0.323286	1	0
FBXW12	285231	broad.mit.edu	37	3	48423302	48423302	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:48423302C>A	ENST00000296438.5	+	9	1284	c.1098C>A	c.(1096-1098)ttC>ttA	p.F366L	FBXW12_ENST00000468158.1_3'UTR|FBXW12_ENST00000445170.1_Missense_Mutation_p.F347L|FBXW12_ENST00000415155.1_Missense_Mutation_p.F296L|FBXW12_ENST00000436231.1_Missense_Mutation_p.F209L	NM_207102.2	NP_996985.2	Q6X9E4	FBW12_HUMAN	F-box and WD repeat domain containing 12	366										breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGTTACTCTTCAGCATCACTG	0.473000													37	70					3.61848e-18	4.71453e-18	0.257332	1	0
CLDN17	26285	broad.mit.edu	37	21	31538609	31538609	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:31538609G>A	ENST00000286808.3	-	1	362	c.327C>T	c.(325-327)ggC>ggT	p.G109G		NM_012131.2	NP_036263.1	P56750	CLD17_HUMAN	claudin 17	109					calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(2)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	23						TCTCGTTAGAGCCTGTGCACT	0.557000													25	172					0	0	0.294199	0	0
INADL	10207	broad.mit.edu	37	1	62321803	62321803	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:62321803C>T	ENST00000371158.2	+	18	2328	c.2214C>T	c.(2212-2214)gtC>gtT	p.V738V	INADL_ENST00000316485.6_Silent_p.V738V	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	738	PDZ 5.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						ACCGCCTGGTCTCAGTCAATG	0.488000													94	159					0	0	0.323286	0	0
ADCY7	113	broad.mit.edu	37	16	50324504	50324504	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:50324504G>T	ENST00000394697.2	+	3	648	c.308G>T	c.(307-309)tGc>tTc	p.C103F	ADCY7_ENST00000537579.1_Missense_Mutation_p.C103F|ADCY7_ENST00000564044.1_Intron|ADCY7_ENST00000254235.3_Missense_Mutation_p.C103F|ADCY7_ENST00000538642.1_Missense_Mutation_p.C103F|ADCY7_ENST00000566433.2_Missense_Mutation_p.C103F			P51828	ADCY7_HUMAN	adenylate cyclase 7	103					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	ACCTGGGCCTGCTTGGTGGCG	0.647000													13	5					1.02788e-11	1.21409e-11	0.160694	1	0
ZEB1	6935	broad.mit.edu	37	10	31812931	31812931	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:31812931C>T	ENST00000446923.2	+	8	3015	c.2624C>T	c.(2623-2625)cCg>cTg	p.P875L	ZEB1_ENST00000361642.5_Missense_Mutation_p.P892L|ZEB1_ENST00000542815.3_Missense_Mutation_p.P824L|ZEB1_ENST00000560721.2_Missense_Mutation_p.P871L|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000320985.10_Missense_Mutation_p.P891L	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	891					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding	p.P891Q(1)		NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GATTCTACACCGCCCAAAAAG	0.363000													39	162					0	0	0.235728	0	0
ADAM30	11085	broad.mit.edu	37	1	120437565	120437565	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:120437565G>C	ENST00000369400.1	-	1	1553	c.1395C>G	c.(1393-1395)gaC>gaG	p.D465E		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	465	Disintegrin.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		ACTCTGCAAGGTCACATTCAT	0.483000													58	181					0	0	0.323286	0	0
GCNT4	51301	broad.mit.edu	37	5	74325437	74325437	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:74325437A>G	ENST00000322348.4	-	1	1287	c.426T>C	c.(424-426)gaT>gaC	p.D142D		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	142					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		CCATAATTGCATCTTTGTGGA	0.388000													90	92					0	0	0.323286	0	0
PAQR3	152559	broad.mit.edu	37	4	79856274	79856274	+	Splice_Site	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:79856274C>T	ENST00000512733.1	-	2	562		c.e2+1		PAQR3_ENST00000295462.3_Intron|PAQR3_ENST00000380645.4_Splice_Site	NM_001040202.1	NP_001035292.1	Q6TCH7	PAQR3_HUMAN	progestin and adipoQ receptor family member III							Golgi membrane|integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	8						AAATGACTTACCTGGAAGCAG	0.413000													392	86					0	0	0.323286	0	0
SYNE1	23345	broad.mit.edu	37	6	152771934	152771934	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:152771934C>A	ENST00000367255.5	-	27	3822	c.3221G>T	c.(3220-3222)tGt>tTt	p.C1074F	SYNE1_ENST00000448038.1_Missense_Mutation_p.C1081F|SYNE1_ENST00000265368.4_Missense_Mutation_p.C1074F|SYNE1_ENST00000367248.3_Missense_Mutation_p.C1064F|SYNE1_ENST00000423061.1_Missense_Mutation_p.C1081F|SYNE1_ENST00000367253.4_Missense_Mutation_p.C1074F|SYNE1_ENST00000341594.5_Missense_Mutation_p.C1140F|SYNE1_ENST00000413186.2_Missense_Mutation_p.C1074F	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1074					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCTTTTCTCACAGAGATGATG	0.443000										HNSCC(10;0.0054)			112	302					1.20168e-53	2.05841e-53	0.323286	1	0
EXOC6	54536	broad.mit.edu	37	10	94757306	94757306	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:94757306A>T	ENST00000371552.4	+	19	2043	c.2014A>T	c.(2014-2016)Agt>Tgt	p.S672C	EXOC6_ENST00000371547.4_Missense_Mutation_p.S693C|EXOC6_ENST00000260762.6_Missense_Mutation_p.S677C|EXOC6_ENST00000443748.2_Missense_Mutation_p.S574C	NM_001013848.2	NP_001013870.1	Q8TAG9	EXOC6_HUMAN	exocyst complex component 6	677					protein transport|vesicle docking involved in exocytosis	exocyst				cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	26		Colorectal(252;0.123)				GCTACTGGACAGTGAGTTAAA	0.378000													76	6					0	0	0.323286	0	0
TRIM58	25893	broad.mit.edu	37	1	248023967	248023967	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248023967G>T	ENST00000366481.3	+	2	517	c.469G>T	c.(469-471)Gcc>Tcc	p.A157S		NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	157						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GTTGGAGGACGCCTTGACTCA	0.483000													28	80					9.21846e-06	9.86169e-06	0.173368	1	0
TFEC	22797	broad.mit.edu	37	7	115624568	115624568	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:115624568C>A	ENST00000265440.7	-	2	109		c.e2-1		TFEC_ENST00000393485.1_Splice_Site|TFEC_ENST00000320239.7_Splice_Site|TFEC_ENST00000484212.1_Splice_Site	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC							nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			GTGCTGGGACCTACAAGATCA	0.403000													28	72					4.22769e-11	4.94642e-11	0.116897	1	0
TAS1R2	80834	broad.mit.edu	37	1	19166621	19166621	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:19166621G>C	ENST00000375371.3	-	6	2013	c.1992C>G	c.(1990-1992)cgC>cgG	p.R664R		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	664					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	CGCGTGGGAAGCGGCTGGCCA	0.562000													52	95					0	0	0.323286	0	0
TNXB	7148	broad.mit.edu	37	6	32065179	32065179	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:32065179G>T	ENST00000375244.3	-	3	652	c.451C>A	c.(451-453)Ctg>Atg	p.L151M	TNXB_ENST00000375247.2_Missense_Mutation_p.L151M|TNXB_ENST00000479795.1_Missense_Mutation_p.L151M			P22105	TENX_HUMAN	tenascin XB	151					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CAGCGGCTCAGATCAAACACA	0.617000													27	68					7.63505e-26	1.0942e-25	0.163468	1	0
PRSS55	203074	broad.mit.edu	37	8	10396302	10396302	+	Nonstop_Mutation	SNP	G	G	C	rs112308687		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:10396302G>C	ENST00000328655.3	+	5	1098	c.1058G>C	c.(1057-1059)tGa>tCa	p.*353S	PRSS55_ENST00000522210.1_Intron|PRSS51_ENST00000523024.1_RNA	NM_198464.3	NP_940866.2	Q6UWB4	PRS55_HUMAN	protease, serine, 55	0					proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						ATTTTGTACTGATAATAAAAT	0.542000													96	18					0	0	0.323286	0	0
EPS8L3	79574	broad.mit.edu	37	1	110300629	110300629	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:110300629C>T	ENST00000369805.3	-	9	1001	c.772G>A	c.(772-774)Gag>Aag	p.E258K	EPS8L3_ENST00000361852.4_Missense_Mutation_p.E257K|RP4-735C1.4_ENST00000431955.1_RNA|EPS8L3_ENST00000361965.4_Missense_Mutation_p.E257K	NM_133181.3|NM_139053.2	NP_573444.2|NP_620641.1	Q8TE67	ES8L3_HUMAN	EPS8-like 3	257						cytoplasm	protein binding			breast(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	32		all_epithelial(167;1.95e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)		Lung(183;0.0245)|Colorectal(144;0.0365)|all cancers(265;0.103)|Epithelial(280;0.109)|LUSC - Lung squamous cell carcinoma(189;0.137)|COAD - Colon adenocarcinoma(174;0.141)		TGGGCCTTCTCCAGCTTTCCC	0.547000													73	39					0	0	0.323286	0	0
PGM5P2	595135	broad.mit.edu	37	9	69127095	69127095	+	RNA	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:69127095A>C	ENST00000591037.1	-	0	463					NR_002836.2																						GGTGTTGACAAGATGCCATTC	0.438000													9	208					0	0	0.069234	0	0
ITGA2	3673	broad.mit.edu	37	5	52347245	52347245	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:52347245G>T	ENST00000296585.5	+	7	778	c.635G>T	c.(634-636)gGg>gTg	p.G212V		NM_002203.3	NP_002194.2	P17301	ITA2_HUMAN	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	212	VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(1)|lung(18)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	47		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				TTGAAGGTGGGGTTAATTCAG	0.303000													46	91					1.33152e-38	2.13002e-38	0.323286	1	0
SLC25A28	81894	broad.mit.edu	37	10	101373554	101373554	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:101373554C>A	ENST00000370495.4	-	2	447	c.419G>T	c.(418-420)gGc>gTc	p.G140V	SLC25A28_ENST00000496035.1_5'UTR	NM_031212.3	NP_112489.3	Q96A46	MFRN2_HUMAN	solute carrier family 25 (mitochondrial iron transporter), member 28	140					ion transport|iron ion homeostasis	integral to membrane|mitochondrial inner membrane				endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|stomach(1)	11		Colorectal(252;0.234)		Epithelial(162;2.57e-10)|all cancers(201;2.01e-08)		AGGCCCTGCGCCTGTTGCTGT	0.537000													20	31					3.6726e-16	4.65768e-16	0.294199	1	0
ACD	65057	broad.mit.edu	37	16	67692248	67692248	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:67692248C>A	ENST00000219251.8	-	10	1427	c.1096G>T	c.(1096-1098)Ggc>Tgc	p.G366C	ACD_ENST00000393919.4_Missense_Mutation_p.G369C	NM_001082486.1|NM_001082487.1|NM_022914.2	NP_001075955.1|NP_001075956.1|NP_075065.2	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog (mouse)	369	Ser-rich.				intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	17		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GACATGTGGCCGGGTAAGGCC	0.632000													8	23					0.000157383	0.000164723	0.278610	1	0
PTGS1	5742	broad.mit.edu	37	9	125148998	125148998	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:125148998A>G	ENST00000362012.2	+	9	1288	c.1283A>G	c.(1282-1284)cAg>cGg	p.Q428R	PTGS1_ENST00000373698.5_Missense_Mutation_p.Q319R|PTGS1_ENST00000223423.4_Intron|PTGS1_ENST00000540753.1_Intron	NM_000962.2|NM_001271164.1|NM_080591.1	NP_000953.2|NP_001258093.1|NP_542158.1	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)	428					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			large_intestine(3)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	8					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TTCTCTCGCCAGATTGCTGGC	0.572000													34	37					0	0	0.246493	0	0
PDE4A	5141	broad.mit.edu	37	19	10559756	10559756	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:10559756G>T	ENST00000380702.2	+	5	484	c.483_splice	c.e5-1	p.V162_splice	PDE4A_ENST00000352831.6_Splice_Site_p.V184_splice|PDE4A_ENST00000293683.5_Splice_Site_p.V158_splice|PDE4A_ENST00000440014.2_Splice_Site_p.V123_splice|PDE4A_ENST00000592685.1_Splice_Site_p.V162_splice			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	184					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CCCATCCCAGGTGCTGGCCAG	0.632000													19	3					2.81731e-10	3.22678e-10	0.153744	1	0
DTX3L	151636	broad.mit.edu	37	3	122289383	122289383	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:122289383G>A	ENST00000296161.4	+	4	2206	c.2017G>A	c.(2017-2019)Gtt>Att	p.V673I	DTX3L_ENST00000383661.3_Missense_Mutation_p.V161I	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	673					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		AGGAAGGAAGGTTTTGAAACT	0.423000													67	143					0	0	0.323286	0	0
ZNF365	22891	broad.mit.edu	37	10	64158504	64158504	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:64158504A>T	ENST00000395254.3	+	4	1210	c.930A>T	c.(928-930)acA>acT	p.T310T	ZNF365_ENST00000410046.3_Intron|ZNF365_ENST00000395255.3_Intron|ZNF365_ENST00000466727.1_3'UTR	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	0										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					TTCAGCTTACAGACATCTCCT	0.313000													30	31					0	0	0.203993	0	0
CLDN17	26285	broad.mit.edu	37	21	31538712	31538712	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:31538712G>T	ENST00000286808.3	-	1	259	c.224C>A	c.(223-225)cCt>cAt	p.P75H		NM_012131.2	NP_036263.1	P56750	CLD17_HUMAN	claudin 17	75					calcium-independent cell-cell adhesion|tight junction assembly	Golgi apparatus|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|breast(1)|endometrium(2)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	23						TTCCAGGGCAGGCGGGAGAGC	0.567000													50	78					2.47907e-22	3.426e-22	0.323286	1	0
IGHV4-61	28391	broad.mit.edu	37	14	107095469	107095469	+	RNA	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:107095469C>G	ENST00000390630.2	-	0	147																											GCCCTGGGATCAGAGGCACCT	0.602000													37	11					0	0	0.268233	0	0
CCT6B	10693	broad.mit.edu	37	17	33281507	33281507	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:33281507C>A	ENST00000314144.5	-	4	563	c.448G>T	c.(448-450)Gat>Tat	p.D150Y	CCT6B_ENST00000436961.3_Missense_Mutation_p.D105Y|CCT6B_ENST00000421975.3_Missense_Mutation_p.D150Y	NM_006584.3	NP_006575.2	Q92526	TCPW_HUMAN	chaperonin containing TCP1, subunit 6B (zeta 2)	150					chaperone-mediated protein complex assembly|protein folding|spermatogenesis	cytoplasm	ATP binding|protein transporter activity|unfolded protein binding			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	20		Ovarian(249;0.17)				CTAGCTACATCTAAGAGGATT	0.333000													22	64					1.96292e-10	2.25656e-10	0.219247	1	0
ZEB2	9839	broad.mit.edu	37	2	145182411	145182411	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:145182411T>A	ENST00000558170.2	-	4	1539	c.355A>T	c.(355-357)Act>Tct	p.T119S	ZEB2_ENST00000539609.3_Intron|ZEB2_ENST00000409487.3_Missense_Mutation_p.T119S|ZEB2_ENST00000303660.4_Missense_Mutation_p.T119S	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	119						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		GGCCCCATAGTGTCATAGTCT	0.438000													53	134					0	0	0.323286	0	0
UNC79	57578	broad.mit.edu	37	14	94120360	94120360	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:94120360C>A	ENST00000553484.1	+	39	6608	c.6454C>A	c.(6454-6456)Cag>Aag	p.Q2152K	UNC79_ENST00000393151.2_Missense_Mutation_p.Q2130K|UNC79_ENST00000555664.1_Missense_Mutation_p.Q2091K|UNC79_ENST00000256339.4_Missense_Mutation_p.Q1953K			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2130						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AGCTCTCAGTCAGCTCCTAGA	0.498000													119	218					1.81142e-54	3.11492e-54	0.323286	1	0
EPB41L4A	64097	broad.mit.edu	37	5	111570404	111570404	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:111570404G>T	ENST00000261486.5	-	12	1290	c.1014C>A	c.(1012-1014)ccC>ccA	p.P338P	RP11-526F3.1_ENST00000504004.1_RNA	NM_022140.3	NP_071423.3	Q9HCS5	E41LA_HUMAN	erythrocyte membrane protein band 4.1 like 4A	338						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(2)|skin(1)	34		all_cancers(142;4.93e-06)|all_epithelial(76;2.28e-08)|Prostate(80;0.000244)|Colorectal(10;0.000788)|Ovarian(225;0.0448)|Lung NSC(167;0.126)|all_lung(232;0.135)		OV - Ovarian serous cystadenocarcinoma(64;6.24e-09)|Epithelial(69;1.43e-07)|all cancers(49;2.78e-05)|COAD - Colon adenocarcinoma(37;0.0467)|Colorectal(14;0.0791)		GATCAGGCCGGGGAAGCTGAA	0.458000													93	142					7.90906e-34	1.22594e-33	0.323286	1	0
ANKS1B	56899	broad.mit.edu	37	12	99194797	99194797	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:99194797T>A	ENST00000547776.2	-	20	3172	c.3173A>T	c.(3172-3174)cAg>cTg	p.Q1058L	ANKS1B_ENST00000333732.7_Missense_Mutation_p.Q88L|ANKS1B_ENST00000549558.2_Missense_Mutation_p.Q224L|ANKS1B_ENST00000546568.1_Missense_Mutation_p.Q224L|ANKS1B_ENST00000329257.7_Missense_Mutation_p.Q1058L|ANKS1B_ENST00000547446.1_Missense_Mutation_p.Q193L|ANKS1B_ENST00000549025.2_Missense_Mutation_p.Q156L|ANKS1B_ENST00000341752.7_Missense_Mutation_p.Q64L|ANKS1B_ENST00000549493.2_Missense_Mutation_p.Q308L|ANKS1B_ENST00000546960.1_Missense_Mutation_p.Q284L|ANKS1B_ENST00000547010.1_Missense_Mutation_p.Q574L|ANKS1B_ENST00000332712.7_Missense_Mutation_p.Q248L|ANKS1B_ENST00000550693.2_Missense_Mutation_p.Q248L	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	1058	PID.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		ATCACACGACTGGAAGATAAG	0.463000													75	14					0	0	0.323286	0	0
ABCC3	8714	broad.mit.edu	37	17	48753029	48753029	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:48753029G>T	ENST00000285238.8	+	21	2832	c.2752G>T	c.(2752-2754)Ggt>Tgt	p.G918C	ABCC3_ENST00000510891.1_3'UTR	NM_003786.3	NP_003777.2	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	918					bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	GGAGGGACAGGGTCGGCCTGT	0.657000													6	13					0.0381472	0.0387605	0.278610	1	0
MPRIP	23164	broad.mit.edu	37	17	17076055	17076055	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:17076055G>C	ENST00000395811.5	+	17	2444	c.2355G>C	c.(2353-2355)cgG>cgC	p.R785R	MPRIP_ENST00000444976.1_Silent_p.R747R|MPRIP_ENST00000341712.4_Silent_p.R785R|MPRIP_ENST00000395804.3_Silent_p.R785R|RP11-45M22.3_ENST00000584203.1_RNA	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	785	Interaction with RHOA.					cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						AAATGGAGCGGGAGCTGGAGA	0.647000													8	11					0	0	0.307466	0	0
HHLA2	11148	broad.mit.edu	37	3	108076997	108076997	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:108076997C>A	ENST00000357759.5	+	6	1406	c.992C>A	c.(991-993)aCa>aAa	p.T331K	HHLA2_ENST00000467761.1_Missense_Mutation_p.T331K|HHLA2_ENST00000489514.2_Missense_Mutation_p.T331K|HHLA2_ENST00000491820.1_Missense_Mutation_p.T331K|HHLA2_ENST00000467562.1_Missense_Mutation_p.T267K	NM_007072.2	NP_009003.1	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2	331						integral to membrane				endometrium(2)|large_intestine(1)|lung(14)|ovary(1)	18						ACCATCCACACAGTGCATGTA	0.348000													44	103					9.39024e-22	1.28566e-21	0.279185	1	0
ESRP1	54845	broad.mit.edu	37	8	95690554	95690554	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:95690554C>T	ENST00000433389.2	+	13	1965	c.1775C>T	c.(1774-1776)cCa>cTa	p.P592L	ESRP1_ENST00000358397.5_Missense_Mutation_p.P588L|ESRP1_ENST00000454170.2_Missense_Mutation_p.P592L|ESRP1_ENST00000423620.2_Missense_Mutation_p.P588L	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	592					mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						GCGTACTACCCAGCAGGCACT	0.502000													33	50					0	0	0.203993	0	0
SLITRK2	84631	broad.mit.edu	37	X	144905726	144905726	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:144905726A>T	ENST00000370490.1	+	1	6038	c.1783A>T	c.(1783-1785)Aat>Tat	p.N595Y	SLITRK2_ENST00000428560.2_Missense_Mutation_p.N595Y|SLITRK2_ENST00000434188.2_Missense_Mutation_p.N595Y|SLITRK2_ENST00000413937.2_Missense_Mutation_p.N595Y|SLITRK2_ENST00000447897.2_Missense_Mutation_p.N595Y			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	595						integral to membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					AATGAATCACAATACAGACAC	0.463000													33	4					0	0	0.193644	0	0
MYH6	4624	broad.mit.edu	37	14	23851757	23851757	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:23851757G>A	ENST00000405093.3	-	38	5746	c.5676C>T	c.(5674-5676)aaC>aaT	p.N1892N	MYH6_ENST00000356287.3_Silent_p.N1892N	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1892					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		ACAGGTTGGTGTTGGCTTGCT	0.587000													49	157					0	0	0.323286	0	0
CSMD1	64478	broad.mit.edu	37	8	3046426	3046426	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:3046426C>A	ENST00000520002.1	-	36	6064	c.5509G>T	c.(5509-5511)Gag>Tag	p.E1837*	CSMD1_ENST00000542608.1_Nonsense_Mutation_p.E1836*|CSMD1_ENST00000539096.1_Nonsense_Mutation_p.E1836*|CSMD1_ENST00000537824.1_Nonsense_Mutation_p.E1836*|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000602723.1_Nonsense_Mutation_p.E1837*|CSMD1_ENST00000400186.3_Nonsense_Mutation_p.E1837*|CSMD1_ENST00000602557.1_Nonsense_Mutation_p.E1837*			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1837	CUB 11.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CCCGAGCCCTCCGTAACTATG	0.478000													7	1					8.12818e-05	8.55061e-05	0.248553	1	0
LPL	4023	broad.mit.edu	37	8	19809404	19809404	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:19809404C>A	ENST00000311322.8	+	3	844	c.374C>A	c.(373-375)gCg>gAg	p.A125E		NM_000237.2	NP_000228.1	P06858	LIPL_HUMAN	lipoprotein lipase	125					fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	36				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	CCAGTGTCCGCGGGCTACACC	0.527000													84	17					2.56433e-40	4.14711e-40	0.323286	1	0
OPRM1	4988	broad.mit.edu	37	6	154412236	154412236	+	Missense_Mutation	SNP	C	C	T	rs17174822	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:154412236C>T	ENST00000414028.2	+	3	843	c.793C>T	c.(793-795)Cgc>Tgc	p.R265C	OPRM1_ENST00000434900.2_Missense_Mutation_p.R358C|OPRM1_ENST00000337049.4_Missense_Mutation_p.R265C|OPRM1_ENST00000435918.2_Missense_Mutation_p.R265C|OPRM1_ENST00000520708.1_Missense_Mutation_p.R165C|OPRM1_ENST00000452687.2_Missense_Mutation_p.R265C|OPRM1_ENST00000522236.1_Missense_Mutation_p.R165C|OPRM1_ENST00000360422.4_Missense_Mutation_p.R265C|OPRM1_ENST00000330432.7_Missense_Mutation_p.R265C|OPRM1_ENST00000524163.1_Missense_Mutation_p.R265C|OPRM1_ENST00000428397.2_Missense_Mutation_p.R265C|OPRM1_ENST00000229768.5_Missense_Mutation_p.R265C|OPRM1_ENST00000419506.2_Missense_Mutation_p.R265C|OPRM1_ENST00000518759.1_Missense_Mutation_p.R184C|OPRM1_ENST00000522555.1_Missense_Mutation_p.R165C	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	265			R -> C (in dbSNP:rs17174822).		behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding	p.R265C(2)|p.R358C(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	CAAGAGTGTCCGCATGCTCTC	0.502000													131	77					0	0	0.323286	0	0
KIAA1045	23349	broad.mit.edu	37	9	34977564	34977564	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:34977564C>G	ENST00000242315.3	+	7	1114	c.1032C>G	c.(1030-1032)atC>atG	p.I344M	KIAA1045_ENST00000476115.2_3'UTR|KIAA1045_ENST00000544237.1_Missense_Mutation_p.I344M	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	344							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			TGGGTCCCATCGCAGATAGCA	0.602000													10	8					0	0	0.093190	0	0
DDI2	84301	broad.mit.edu	37	1	15970134	15970134	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:15970134G>T	ENST00000480945.1	+	6	1049	c.878G>T	c.(877-879)aGg>aTg	p.R293M		NM_032341.4	NP_115717.3	Q5TDH0	DDI2_HUMAN	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	293					proteolysis		aspartic-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|stomach(1)	17		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		ATTATTGGAAGGGTACATCTA	0.478000													49	105					1.07234e-20	1.44771e-20	0.323286	1	0
NUTM2F	54754	broad.mit.edu	37	9	97087698	97087698	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:97087698G>T	ENST00000335456.7	-	2	555	c.535C>A	c.(535-537)Cca>Aca	p.P179T	NUTM2F_ENST00000341207.4_Missense_Mutation_p.P179T|NUTM2F_ENST00000253262.4_Missense_Mutation_p.P179T					NUT family member 2F																		GCCCCTTGTGGCCATGGCCTA	0.657000													21	24					8.24728e-16	1.0421e-15	0.309145	1	0
LAMA3	3909	broad.mit.edu	37	18	21437854	21437854	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:21437854G>T	ENST00000313654.9	+	33	4424	c.4183G>T	c.(4183-4185)Ggg>Tgg	p.G1395W	LAMA3_ENST00000399516.3_Missense_Mutation_p.G1395W	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1395	Domain III B.|Laminin EGF-like 11.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATGTGCTTCCGGGTTTTACCG	0.502000													106	94					5.67207e-43	9.29439e-43	0.323286	1	0
PYGO2	90780	broad.mit.edu	37	1	154931577	154931577	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:154931577C>A	ENST00000368457.2	-	3	1070	c.899G>T	c.(898-900)gGg>gTg	p.G300V	PYGO2_ENST00000368456.1_Missense_Mutation_p.G263V	NM_138300.3	NP_612157.1	Q9BRQ0	PYGO2_HUMAN	pygopus family PHD finger 2	300	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)|skin(2)|urinary_tract(1)	10	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TGGAGTGCCCCCACCCCGCCC	0.667000													4	6					0.150653	0.152375	0.150653	1	0
NUSAP1	51203	broad.mit.edu	37	15	41657777	41657777	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:41657777A>G	ENST00000260359.6	+	7	1057	c.793A>G	c.(793-795)Acg>Gcg	p.T265A	NUSAP1_ENST00000450318.1_Missense_Mutation_p.T280A|NUSAP1_ENST00000560747.1_Missense_Mutation_p.T278A|NUSAP1_ENST00000414849.2_Missense_Mutation_p.T279A|NUSAP1_ENST00000558123.1_3'UTR|NUSAP1_ENST00000560177.1_Missense_Mutation_p.T279A|NUSAP1_ENST00000450592.2_Missense_Mutation_p.T256A|NUSAP1_ENST00000559596.1_Missense_Mutation_p.T280A	NM_001243142.1|NM_001243143.1|NM_016359.4|NM_018454.7	NP_001230071.1|NP_001230072.1|NP_057443.2|NP_060924.4	Q9BXS6	NUSAP_HUMAN	nucleolar and spindle associated protein 1	280	Interaction with microtubules (By similarity).				cytokinesis after mitosis|establishment of mitotic spindle localization|mitotic chromosome condensation|positive regulation of mitosis	chromosome|cytoplasm|nucleolus	DNA binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(3)|ovary(1)|prostate(2)|urinary_tract(2)	13		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;9.63e-17)|GBM - Glioblastoma multiforme(113;1.59e-06)|BRCA - Breast invasive adenocarcinoma(123;0.168)		TGCAGCTAAAACGGGTGTCAG	0.428000													12	2					0	0	0.093190	0	0
CNTN1	1272	broad.mit.edu	37	12	41323682	41323682	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:41323682G>T	ENST00000551295.2	+	7	698	c.581G>T	c.(580-582)gGc>gTc	p.G194V	CNTN1_ENST00000547702.1_Missense_Mutation_p.G194V|CNTN1_ENST00000547849.1_Missense_Mutation_p.G194V|CNTN1_ENST00000360099.3_Missense_Mutation_p.G194V|CNTN1_ENST00000347616.1_Missense_Mutation_p.G194V|CNTN1_ENST00000348761.2_Missense_Mutation_p.G183V	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	194	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CAGACAAATGGCAATCTCTAC	0.383000													156	309					1.37695e-83	2.48364e-83	0.323286	1	0
NCAM1	4684	broad.mit.edu	37	11	113105836	113105836	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:113105836A>T	ENST00000316851.7	+	13	1745	c.1745A>T	c.(1744-1746)aAa>aTa	p.K582I	NCAM1_ENST00000533760.1_Missense_Mutation_p.K464I|NCAM1_ENST00000401611.2_Missense_Mutation_p.K591I|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	592	Fibronectin type-III 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		CTCAATGGCAAAGGGCTGGGT	0.597000													7	22					0	0	0.278610	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626793	140626793	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140626793G>C	ENST00000231173.3	+	1	1647	c.1647G>C	c.(1645-1647)gtG>gtC	p.V549V		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		549	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGCGAGTGCTGGTGCTGG	0.716000													22	21					0	0	0.294199	0	0
TIAM1	7074	broad.mit.edu	37	21	32617897	32617897	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:32617897C>A	ENST00000286827.3	-	7	1962	c.1491G>T	c.(1489-1491)gtG>gtT	p.V497V	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Silent_p.V497V	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	497	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TGCTGTTCTCCACCCAGACGG	0.537000													64	58					3.36121e-32	5.13803e-32	0.323286	1	0
CACNA1D	776	broad.mit.edu	37	3	53707833	53707833	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:53707833G>T	ENST00000288139.3	+	8	1328	c.1210G>T	c.(1210-1212)Gtc>Ttc	p.V404F	CACNA1D_ENST00000498251.1_Intron|CACNA1D_ENST00000422281.2_Intron|CACNA1D_ENST00000350061.5_Intron	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	404					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	GGTTCTTGGTGTCCTTAGTGG	0.498000													25	71					1.77063e-15	2.22822e-15	0.324025	1	0
ZNF407	55628	broad.mit.edu	37	18	72345693	72345693	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:72345693G>T	ENST00000299687.5	+	1	2718	c.2718G>T	c.(2716-2718)cgG>cgT	p.R906R	ZNF407_ENST00000577538.1_Silent_p.R906R|ZNF407_ENST00000309902.6_Silent_p.R906R|ZNF407_ENST00000582337.1_Silent_p.R906R	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	906					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		ATAAAGGACGGGTAGAAATAG	0.418000													118	61					2.4537e-52	4.17533e-52	0.323286	1	0
DSCAML1	57453	broad.mit.edu	37	11	117310621	117310621	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:117310621G>T	ENST00000321322.6	-	22	4075	c.4074C>A	c.(4072-4074)acC>acA	p.T1358T	DSCAML1_ENST00000527706.1_Silent_p.T1088T	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1298	Ig-like C2-type 10.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTGTTGTCACGGTGCCCCCAA	0.562000													35	91					1.836e-18	2.3992e-18	0.193644	1	0
CAMK2D	817	broad.mit.edu	37	4	114468842	114468842	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:114468842C>G	ENST00000511664.1	-	6	521	c.372G>C	c.(370-372)gtG>gtC	p.V124V	CAMK2D_ENST00000514328.1_Intron|CAMK2D_ENST00000394526.2_Intron|CAMK2D_ENST00000296402.5_Intron|CAMK2D_ENST00000505990.1_Silent_p.V124V|CAMK2D_ENST00000508738.1_Intron|CAMK2D_ENST00000429180.1_Intron|CAMK2D_ENST00000342666.5_Intron|CAMK2D_ENST00000379773.2_Intron|CAMK2D_ENST00000394524.3_Intron|CAMK2D_ENST00000454265.2_Intron|CAMK2D_ENST00000515496.1_Intron|CAMK2D_ENST00000418639.2_Intron|CAMK2D_ENST00000394522.3_Intron			Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II delta	124	Protein kinase.				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	13		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		GGCAGTGTAGCACAGCCTCCA	0.507000											OREG0016299	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	1					0	0	0.307466	0	0
INHBE	83729	broad.mit.edu	37	12	57849344	57849344	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:57849344T>C	ENST00000266646.2	+	1	241	c.25T>C	c.(25-27)Tgg>Cgg	p.W9R	INHBE_ENST00000551553.1_Intron	NM_031479.3	NP_113667.1	P58166	INHBE_HUMAN	inhibin, beta E	9					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						TGTCCAGCTCTGGCTGGTGCT	0.632000													18	58					0	0	0.309145	0	0
TTC13	79573	broad.mit.edu	37	1	231097014	231097014	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:231097014C>A	ENST00000366661.4	-	2	314	c.307G>T	c.(307-309)Gaa>Taa	p.E103*	TTC13_ENST00000366662.4_Nonsense_Mutation_p.E103*|TTC13_ENST00000414259.1_Nonsense_Mutation_p.E103*	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13	103							binding			central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CCCTTGGGTTCGCAGTCTGAG	0.418000													20	83					3.51602e-12	4.18973e-12	0.204396	1	0
UBE3C	9690	broad.mit.edu	37	7	156976595	156976595	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:156976595C>G	ENST00000348165.5	+	9	1375	c.1015C>G	c.(1015-1017)Ctg>Gtg	p.L339V	UBE3C_ENST00000389103.4_Missense_Mutation_p.L296V	NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	339					protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		GGAAGGGCTGCTGGTGTATTT	0.473000													44	127					0	0	0.323286	0	0
BNC1	646	broad.mit.edu	37	15	83931885	83931885	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:83931885C>G	ENST00000345382.2	-	4	2203	c.2118G>C	c.(2116-2118)gtG>gtC	p.V706V	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Silent_p.V699V	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	706					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						CATGCTGACCCACGTGCTCCA	0.463000													31	101					0	0	0.163468	0	0
OR4M1	441670	broad.mit.edu	37	14	20248670	20248670	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20248670G>T	ENST00000315957.4	+	1	270	c.189G>T	c.(187-189)ttG>ttT	p.L63F		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTTCCTGTTGGCTAATCTGG	0.403000													200	891					2.20771e-55	3.8006e-55	0.323286	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319339	21319339	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:21319339C>G	ENST00000583088.1	+	3	1580	c.685C>G	c.(685-687)Cgc>Ggc	p.R229G	KCNJ12_ENST00000331718.5_Missense_Mutation_p.R229G	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.R229G(1)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GGCCCATGTGCGCGCGCAGCT	0.642000										Prostate(3;0.18)			8	26					0	0	0.080935	0	0
NAP1L3	4675	broad.mit.edu	37	X	92927797	92927797	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:92927797C>G	ENST00000373079.3	-	1	770	c.507G>C	c.(505-507)gaG>gaC	p.E169D	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	169	Glu-rich.				nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						TGCTGAACTCCTCATCCTCTG	0.453000													30	50					0	0	0.183431	0	0
COL11A1	1301	broad.mit.edu	37	1	103352455	103352455	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:103352455T>C	ENST00000358392.2	-	63	5119	c.4802A>G	c.(4801-4803)gAc>gGc	p.D1601G	COL11A1_ENST00000370096.3_Missense_Mutation_p.D1589G|COL11A1_ENST00000353414.4_Missense_Mutation_p.D1550G|COL11A1_ENST00000512756.1_Missense_Mutation_p.D1473G	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1589	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ATGCTCAATGTCTTGTTTCAG	0.418000													45	96					0	0	0.323286	0	0
CASKIN1	57524	broad.mit.edu	37	16	2237394	2237394	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:2237394G>T	ENST00000343516.6	-	7	778	c.686C>A	c.(685-687)gCg>gAg	p.A229E		NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	229					signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						TCCGCAGAGCGCAGCCTCGTG	0.682000													5	8					2.0095e-06	2.16919e-06	0.248553	1	0
CYP27C1	339761	broad.mit.edu	37	2	127960975	127960975	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:127960975C>A	ENST00000335247.7	-	2	281	c.151G>T	c.(151-153)Gat>Tat	p.D51Y	CYP27C1_ENST00000409327.1_Missense_Mutation_p.D51Y	NM_001001665.3	NP_001001665.3	Q4G0S4	C27C1_HUMAN	cytochrome P450, family 27, subfamily C, polypeptide 1	51						membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|stomach(1)	16	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.071)		AAGAAAAGATCATTGACATTG	0.433000													25	75					1.1804e-14	1.46579e-14	0.294199	1	0
TRPV5	56302	broad.mit.edu	37	7	142627252	142627252	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142627252G>C	ENST00000265310.1	-	3	598	c.250C>G	c.(250-252)Cac>Gac	p.H84D	TRPV5_ENST00000442623.1_Missense_Mutation_p.H84D	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	84					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GCTGCTATGTGCAGCGCCGTC	0.577000													28	120					0	0	0.214465	0	0
FAT1	2195	broad.mit.edu	37	4	187540974	187540974	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:187540974C>A	ENST00000441802.2	-	10	6975	c.6766G>T	c.(6766-6768)Gca>Tca	p.A2256S		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2256	Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GAGTCAGTTGCGCGTATGCTC	0.473000										HNSCC(5;0.00058)			95	154					2.28175e-60	4.00146e-60	0.323286	1	0
PROX2	283571	broad.mit.edu	37	14	75329253	75329253	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:75329253G>T	ENST00000556489.2	-	1	1284	c.1285C>A	c.(1285-1287)Ctg>Atg	p.L429M	PROX2_ENST00000445876.1_Missense_Mutation_p.L429M|PROX2_ENST00000556084.2_Intron	NM_001243007.1	NP_001229936.1	Q3B8N5	PROX2_HUMAN	prospero homeobox 2	429					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			kidney(1)|large_intestine(2)|lung(3)	6			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00652)		GAGAAAGGCAGTGCCTCCATG	0.507000													76	92					1.31589e-24	1.86172e-24	0.323286	1	0
MGAT5B	146664	broad.mit.edu	37	17	74934143	74934143	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:74934143G>A	ENST00000569840.2	+	13	2076	c.1502G>A	c.(1501-1503)cGg>cAg	p.R501Q	MGAT5B_ENST00000301618.4_Missense_Mutation_p.R499Q|MGAT5B_ENST00000428789.2_Missense_Mutation_p.R510Q	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	501						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GAGAGCCAGCGGCCCCCCGAG	0.582000													35	42					0	0	0.268233	0	0
PCDH12	51294	broad.mit.edu	37	5	141325203	141325203	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:141325203G>A	ENST00000231484.3	-	4	4508	c.3298C>T	c.(3298-3300)Cca>Tca	p.P1100S		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	1100					neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCCTGTTGGGCTCAGCTCT	0.627000													32	34					0	0	0.214465	0	0
MARS2	92935	broad.mit.edu	37	2	198570940	198570940	+	Missense_Mutation	SNP	G	G	T	rs145093633	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:198570940G>T	ENST00000282276.6	+	1	854	c.811G>T	c.(811-813)Gat>Tat	p.D271Y	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	271					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	GGTGCCCGGGGATGATTCGCA	0.552000													25	29					1.55811e-20	2.09986e-20	0.134883	1	0
SPTY2D1	144108	broad.mit.edu	37	11	18636397	18636397	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:18636397A>C	ENST00000336349.5	-	3	1659	c.1424T>G	c.(1423-1425)cTt>cGt	p.L475R		NM_194285.2	NP_919261.2	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)	475	Ser-rich.									breast(4)|cervix(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|skin(1)|stomach(1)	30						TGGTCGTCGAAGTTCATGTGG	0.612000													16	23					0	0	0.279207	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414042	105414042	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:105414042C>A	ENST00000333244.5	-	7	7865	c.7746G>T	c.(7744-7746)aaG>aaT	p.K2582N	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2582						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GCTGGGGGCCCTTGAGGTCCA	0.617000													34	68					6.97489e-18	9.03439e-18	0.214465	1	0
SLC2A7	155184	broad.mit.edu	37	1	9085120	9085120	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:9085120G>T	ENST00000400906.1	-	2	64	c.65C>A	c.(64-66)aCg>aAg	p.T22K		NM_207420.2	NP_997303.2	Q6PXP3	GTR7_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 7	22						integral to membrane|plasma membrane	sugar transmembrane transporter activity			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|lung(4)|prostate(2)|skin(2)	24	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		CAGCAACAGCGTCGGCTGGAG	0.652000													9	5					0.00136819	0.00141243	0.093190	1	0
KRT5	3852	broad.mit.edu	37	12	52913793	52913793	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:52913793G>T	ENST00000252242.4	-	1	678	c.288C>A	c.(286-288)ggC>ggA	p.G96G		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	96	Gly-rich.|Head.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		cacctccaaagccatagccgc	0.622000													51	128					2.93687e-30	4.39821e-30	0.323286	1	0
OR52A4P	390053	broad.mit.edu	37	11	5142859	5142859	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:5142859G>T	ENST00000498233.1	-	0	539																				breast(1)|endometrium(2)|kidney(1)|lung(12)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		GTGATTCTCTGTACTTTTATA	0.363000													145	14					1.50598e-64	2.65756e-64	0.323286	1	0
TRIOBP	11078	broad.mit.edu	37	22	38155174	38155174	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:38155174G>T	ENST00000406386.3	+	17	6482	c.6227G>T	c.(6226-6228)cGg>cTg	p.R2076L	TRIOBP_ENST00000407319.2_Missense_Mutation_p.R363L|TRIOBP_ENST00000403663.2_Missense_Mutation_p.R363L|RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2076					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CAGGCTCTTCGGGCCCAGCTG	0.652000													15	0					2.23348e-06	2.40595e-06	0.146539	1	0
NKX2-3	159296	broad.mit.edu	37	10	101294877	101294877	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:101294877G>A	ENST00000344586.7	+	2	693	c.494G>A	c.(493-495)cGc>cAc	p.R165H		NM_145285.2	NP_660328.2	Q8TAU0	NKX23_HUMAN	NK2 homeobox 3	165						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R165H(1)		endometrium(1)|kidney(1)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	5		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.45e-08)		GAGCTGGAACGCAGGTTCAAG	0.642000													5	31					0	0	0.217242	0	0
ABCC4	10257	broad.mit.edu	37	13	95830321	95830321	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:95830321C>A	ENST00000376887.4	-	12	1684	c.1570G>T	c.(1570-1572)Gat>Tat	p.D524Y	ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000536256.1_Missense_Mutation_p.D449Y|ABCC4_ENST00000431522.1_Missense_Mutation_p.D524Y|ABCC4_ENST00000412704.1_Missense_Mutation_p.D524Y	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	524	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	ACAGTCAGATCACCATCCTCC	0.473000													59	329					2.17656e-39	3.50171e-39	0.323286	1	0
LINC01410	103352539	broad.mit.edu	37	9	66457986	66457986	+	RNA	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:66457986G>A	ENST00000424345.1	+	0	67																											CGGAAGAGGTGGGATGCTGCT	0.731000													5	22					0	0	0.278610	0	0
NRBF2	29982	broad.mit.edu	37	10	64913808	64913808	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:64913808C>T	ENST00000277746.6	+	4	875	c.694C>T	c.(694-696)Cca>Tca	p.P232S	NRBF2_ENST00000435510.2_Missense_Mutation_p.P222S	NM_030759.3	NP_110386.2	Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	232					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding			large_intestine(2)|lung(3)|skin(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					GAGCTTGCCACCACATGCAGA	0.468000													21	45					0	0	0.279207	0	0
RSPH3	83861	broad.mit.edu	37	6	159403567	159403567	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:159403567C>A	ENST00000367069.2	-	5	1282	c.646G>T	c.(646-648)Gct>Tct	p.A216S	RSPH3_ENST00000252655.1_Missense_Mutation_p.A358S|RSPH3_ENST00000449822.1_Missense_Mutation_p.A120S|RSPH3_ENST00000297262.3_Missense_Mutation_p.A262S			Q86UC2	RSPH3_HUMAN	radial spoke 3 homolog (Chlamydomonas)	358										endometrium(3)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|skin(1)|stomach(7)	23		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.36e-16)|BRCA - Breast invasive adenocarcinoma(81;5.92e-06)		TGAACTTCAGCACGTTCACTA	0.428000													18	48					1.40151e-16	1.78694e-16	0.219247	1	0
IMPG1	3617	broad.mit.edu	37	6	76713660	76713660	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:76713660A>T	ENST00000369950.3	-	11	1332	c.1143T>A	c.(1141-1143)gcT>gcA	p.A381A	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	381					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				GCAGTGATCCAGCAATTTCTA	0.383000													22	58					0	0	0.249174	0	0
A2ML1	144568	broad.mit.edu	37	12	8990976	8990976	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:8990976C>A	ENST00000299698.7	+	9	1080	c.900C>A	c.(898-900)acC>acA	p.T300T		NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	144						extracellular space	endopeptidase inhibitor activity	p.T300T(1)		NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						ACATGGCCACCTTTGACCTCA	0.458000													67	161					1.43987e-31	2.18699e-31	0.323286	1	0
GALNT3	2591	broad.mit.edu	37	2	166606373	166606373	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:166606373C>A	ENST00000392701.3	-	10	2433	c.1658G>T	c.(1657-1659)cGg>cTg	p.R553L	GALNT3_ENST00000409882.1_Missense_Mutation_p.R291L	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	553	Ricin B-type lectin.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.R553Q(1)		NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						GATGTTGTGCCGAATTTCATG	0.408000													87	278					1.52223e-32	2.33615e-32	0.323286	1	0
PLIN1	5346	broad.mit.edu	37	15	90210328	90210328	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:90210328C>G	ENST00000300055.5	-	8	1213	c.1048G>C	c.(1048-1050)Gtg>Ctg	p.V350L	PLIN1_ENST00000430628.2_Missense_Mutation_p.V350L	NM_002666.4	NP_002657.3	O60240	PLIN1_HUMAN	perilipin 1	350					triglyceride catabolic process	lipid particle	lipid binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|skin(2)	13						GCCCATGTCACAGCCGAGATG	0.657000													69	56					0	0	0.323286	0	0
EPHA7	2045	broad.mit.edu	37	6	94120810	94120810	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:94120810G>T	ENST00000369303.4	-	3	425	c.241C>A	c.(241-243)Caa>Aaa	p.Q81K	EPHA7_ENST00000369297.1_Missense_Mutation_p.Q81K	NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	81						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CAGTTGTTTTGGTTGGGCTCC	0.428000													45	116					5.2432e-18	6.81418e-18	0.323286	1	0
RGS8	85397	broad.mit.edu	37	1	182615997	182615997	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:182615997G>T	ENST00000483095.2	-	7	673	c.416C>A	c.(415-417)tCc>tAc	p.S139Y	RGS8_ENST00000367557.4_Missense_Mutation_p.S139Y|RGS8_ENST00000258302.4_Missense_Mutation_p.S157Y|RGS8_ENST00000367556.1_Missense_Mutation_p.S139Y			P57771	RGS8_HUMAN	regulator of G-protein signaling 8	139	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	5						GCAAGTCAGGGATGGCTCCTG	0.507000													129	81					1.12709e-80	2.02471e-80	0.323286	1	0
ADRA2C	152	broad.mit.edu	37	4	3768794	3768794	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:3768794C>T	ENST00000330055.5	+	1	670	c.461C>T	c.(460-462)aCg>aTg	p.T154M	ADRA2C_ENST00000509482.1_Missense_Mutation_p.T154M	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	154					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	TGGTCGGTGACGCAGGCCGTC	0.642000													7	6					0	0	0.278610	0	0
LNX1	84708	broad.mit.edu	37	4	54362242	54362242	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:54362242T>C	ENST00000306888.2	-	5	1261	c.1010A>G	c.(1009-1011)aAt>aGt	p.N337S	FIP1L1_ENST00000507166.1_Intron|LNX1_ENST00000263925.7_Missense_Mutation_p.N433S	NM_032622.2	NP_116011.2	Q8TBB1	LNX1_HUMAN	ligand of numb-protein X 1, E3 ubiquitin protein ligase	433	PDZ 1.					cytoplasm	zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|endometrium(3)|large_intestine(11)|lung(6)|ovary(3)|urinary_tract(4)	32	all_neural(26;0.153)		GBM - Glioblastoma multiforme(3;8.2e-46)|LUSC - Lung squamous cell carcinoma(32;0.0134)			ATCATGTCCATTGATGGCTAA	0.512000													112	396					0	0	0.323286	0	0
BSND	7809	broad.mit.edu	37	1	55472900	55472900	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:55472900C>T	ENST00000371265.4	+	3	757	c.503C>T	c.(502-504)tCa>tTa	p.S168L		NM_057176.2	NP_476517.1	Q8WZ55	BSND_HUMAN	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	168						basolateral plasma membrane|cytoplasm|integral to plasma membrane|protein complex				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	17						CACAAGGGCTCAGACGAGAGT	0.607000													50	115					0	0	0.323286	0	0
KRT77	374454	broad.mit.edu	37	12	53086372	53086372	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:53086372G>T	ENST00000341809.3	-	7	1288	c.1260C>A	c.(1258-1260)gcC>gcA	p.A420A	KRT77_ENST00000537195.1_Silent_p.A187A	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	420	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CATCCTGGAGGGCCTGCTCGC	0.582000													49	95					6.56871e-35	1.02485e-34	0.323286	1	0
ABCA6	23460	broad.mit.edu	37	17	67081858	67081858	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:67081858C>A	ENST00000284425.2	-	31	4112		c.e31-1		ABCA6_ENST00000446604.2_Splice_Site	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6						transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AAAATTTCACCTGAAAGAAAG	0.393000													71	177					2.72187e-29	4.03718e-29	0.323286	1	0
TMEM231	79583	broad.mit.edu	37	16	75579318	75579318	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:75579318C>A	ENST00000398114.2	-	3	639	c.601G>T	c.(601-603)Gtg>Ttg	p.V201L	RP11-77K12.7_ENST00000460606.1_Silent_p.T3T|RP11-77K12.8_ENST00000564489.1_RNA|TMEM231_ENST00000258173.6_Missense_Mutation_p.V172L|TMEM231_ENST00000569294.1_5'UTR|TMEM231_ENST00000565067.1_Intron	NM_001077416.1	NP_001070884.1	Q9H6L2	TM231_HUMAN	transmembrane protein 231	172						integral to membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						TCTCCGTTCACGTATAACTGG	0.547000													38	77					1.50631e-41	2.44499e-41	0.323286	1	0
C12orf40	283461	broad.mit.edu	37	12	40040149	40040149	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:40040149C>A	ENST00000324616.5	+	4	375	c.221C>A	c.(220-222)aCc>aAc	p.T74N	C12orf40_ENST00000405531.3_Missense_Mutation_p.T74N|C12orf40_ENST00000398716.1_5'UTR	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	74										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						AGAAAACCAACCCATGTGAAC	0.269000													131	49					2.03441e-48	3.40387e-48	0.323286	1	0
COLGALT2	23127	broad.mit.edu	37	1	183909826	183909826	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:183909826A>G	ENST00000361927.4	-	11	1864	c.1493T>C	c.(1492-1494)cTg>cCg	p.L498P	COLGALT2_ENST00000367521.1_Missense_Mutation_p.L106P|COLGALT2_ENST00000546159.1_Missense_Mutation_p.L498P|COLGALT2_ENST00000367520.3_Missense_Mutation_p.L235P|COLGALT2_ENST00000486375.1_5'UTR	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		GACGTAGCCCAGGGTCCAGTA	0.502000													102	72					0	0	0.323286	0	0
FOXG1	2290	broad.mit.edu	37	14	29237250	29237250	+	Missense_Mutation	SNP	G	G	T	rs121913678		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:29237250G>T	ENST00000382535.3	+	2	1134	c.765G>T	c.(763-765)tgG>tgT	p.W255C	FOXG1_ENST00000313071.4_Missense_Mutation_p.W255C			P55316	FOXG1_HUMAN	forkhead box G1	255					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		GCAACTACTGGATGCTGGACC	0.662000													28	54					2.09667e-21	2.85298e-21	0.193644	1	0
CSMD1	64478	broad.mit.edu	37	8	2855626	2855626	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:2855626A>T	ENST00000520002.1	-	55	8842	c.8287T>A	c.(8287-8289)Ttc>Atc	p.F2763I	CSMD1_ENST00000542608.1_Missense_Mutation_p.F2704I|CSMD1_ENST00000537824.1_Missense_Mutation_p.F2762I|CSMD1_ENST00000602723.1_Missense_Mutation_p.F2705I|CSMD1_ENST00000400186.3_Missense_Mutation_p.F2705I|CSMD1_ENST00000602557.1_Missense_Mutation_p.F2763I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2763	Sushi 19.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTGCAGGTGAAATTCACGACA	0.557000													91	18					0	0	0.323286	0	0
TNS3	64759	broad.mit.edu	37	7	47336694	47336694	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:47336694T>A	ENST00000398879.1	-	24	4028	c.3662A>T	c.(3661-3663)cAg>cTg	p.Q1221L	TNS3_ENST00000355730.3_Missense_Mutation_p.Q981L|TNS3_ENST00000311160.9_Missense_Mutation_p.Q1221L			Q68CZ2	TENS3_HUMAN	tensin 3	1221	SH2.					focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						CTTGTTCAGCTGCAGGACTGA	0.488000													47	175					0	0	0.323286	0	0
FOXB1	27023	broad.mit.edu	37	15	60297527	60297527	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:60297527C>A	ENST00000396057.4	+	2	844	c.365C>A	c.(364-366)cCa>cAa	p.P122Q	FOXB1_ENST00000560857.1_Intron	NM_012182.2	NP_036314.2	Q99853	FOXB1_HUMAN	forkhead box B1	122					axon target recognition|cell migration in diencephalon|epithelial cell differentiation involved in mammary gland alveolus development|floor plate development|hypothalamus cell migration|inferior colliculus development|lactation|mammillothalamic axonal tract development|negative regulation of neuron apoptosis|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|telencephalon cell migration|visual learning	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|kidney(1)|lung(3)|ovary(1)	6						CCCAGCAAGCCAGCCGACGCG	0.701000													11	2					6.31663e-08	6.96674e-08	0.132662	1	0
TRPV1	7442	broad.mit.edu	37	17	3470119	3470119	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:3470119C>A	ENST00000174621.6	-	15	2793	c.2504G>T	c.(2503-2505)gGg>gTg	p.G835V	TRPV1_ENST00000310522.5_Missense_Mutation_p.G777V|TRPV1_ENST00000576351.1_Missense_Mutation_p.G827V|TRPV1_ENST00000571088.1_Missense_Mutation_p.G837V|TRPV1_ENST00000399759.3_Missense_Mutation_p.G837V|TRPV1_ENST00000399756.4_Missense_Mutation_p.G837V|TRPV1_ENST00000425167.2_Missense_Mutation_p.G848V|SHPK_ENST00000572705.1_Missense_Mutation_p.G837V			Q8NER1	TRPV1_HUMAN	transient receptor potential cation channel, subfamily V, member 1	837					cell surface receptor linked signaling pathway|chemosensory behavior|thermoception	cell junction|dendritic spine membrane|integral to plasma membrane|postsynaptic membrane	ATP binding|calcium channel activity|calmodulin binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	17				Lung(1;0.055)|COAD - Colon adenocarcinoma(5;0.0896)|LUAD - Lung adenocarcinoma(1115;0.131)	Alpha-Linolenic Acid(DB00132)|Aspartame(DB00168)|Icosapent(DB00159)	TCACTTCTCCCCGGAAGCGGC	0.592000													18	23					4.72057e-08	5.21756e-08	0.294199	1	0
OR6C3	254786	broad.mit.edu	37	12	55725587	55725587	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55725587A>C	ENST00000379667.1	+	1	103	c.103A>C	c.(103-105)Agt>Cgt	p.S35R		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						GTATATATTAAGTGTTACTGG	0.403000													106	177					0	0	0.323286	0	0
PTK2	5747	broad.mit.edu	37	8	141696760	141696760	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:141696760C>A	ENST00000522684.1	-	27	2762	c.2533G>T	c.(2533-2535)Gac>Tac	p.D845Y	PTK2_ENST00000340930.3_Missense_Mutation_p.D845Y|PTK2_ENST00000535192.1_Missense_Mutation_p.D799Y|PTK2_ENST00000538769.1_Missense_Mutation_p.D513Y|PTK2_ENST00000430260.2_Missense_Mutation_p.D155Y|PTK2_ENST00000519419.1_Missense_Mutation_p.D889Y|PTK2_ENST00000395218.2_Missense_Mutation_p.D845Y|PTK2_ENST00000521059.1_Missense_Mutation_p.D845Y|PTK2_ENST00000519465.1_Missense_Mutation_p.D473Y|PTK2_ENST00000517887.1_Missense_Mutation_p.D889Y	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	845	Interaction with TGFB1I1.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			TCCTCCCTGTCAATACTGCCT	0.393000													43	51					3.50607e-19	4.63633e-19	0.323286	1	0
NTSR2	23620	broad.mit.edu	37	2	11800230	11800230	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:11800230A>T	ENST00000306928.5	-	3	962	c.928T>A	c.(928-930)Tgg>Agg	p.W310R		NM_012344.3	NP_036476.1	O95665	NTR2_HUMAN	neurotensin receptor 2	310					sensory perception	integral to plasma membrane				breast(1)|large_intestine(7)|lung(7)|prostate(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.129)|OV - Ovarian serous cystadenocarcinoma(76;0.24)	Levocabastine(DB01106)	TACGGCAGCCAGCAGATGACA	0.552000													23	15					0	0	0.183431	0	0
SNF8	11267	broad.mit.edu	37	17	47014474	47014474	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:47014474A>C	ENST00000502492.1	-	4	639	c.257T>G	c.(256-258)tTt>tGt	p.F86C	SNF8_ENST00000514089.1_5'UTR|SNF8_ENST00000290330.3_Missense_Mutation_p.F86C			Q96H20	SNF8_HUMAN	SNF8, ESCRT-II complex subunit	86					cellular membrane organization|endosome transport|protein transport|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytosol|late endosome membrane|transcription factor complex	transcription factor binding			breast(1)|endometrium(1)|lung(1)	3						CTCAGACCAAAATCCTTTTCC	0.418000													77	158					0	0	0.323286	0	0
TSHR	7253	broad.mit.edu	37	14	81606051	81606051	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:81606051C>G	ENST00000541158.2	+	10	1043	c.721C>G	c.(721-723)Ctt>Gtt	p.L241V	RP11-114N19.3_ENST00000557775.1_RNA|TSHR_ENST00000298171.2_Missense_Mutation_p.L241V			P16473	TSHR_HUMAN	thyroid stimulating hormone receptor	241					cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(2)|stomach(1)|thyroid(291)|upper_aerodigestive_tract(1)	337				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TGTCACTGCCCTTCCATCCAA	0.522000			Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism						93	100					0	0	0.323286	0	0
TAF7	6879	broad.mit.edu	37	5	140699320	140699320	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140699320T>C	ENST00000313368.5	-	1	1010	c.292A>G	c.(292-294)Aca>Gca	p.T98A		NM_005642.2	NP_005633.2	Q15545	TAF7_HUMAN	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	98					negative regulation of histone acetylation|negative regulation of protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|spermine transport|transcription initiation from RNA polymerase II promoter	Golgi apparatus|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	histone acetyltransferase binding|thyroid hormone receptor binding|transcription coactivator activity|transcription regulatory region DNA binding|vitamin D receptor binding			central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATCAACTGTGGATACAAGC	0.388000													39	37					0	0	0.323286	0	0
SLC5A3	6526	broad.mit.edu	37	21	35467934	35467934	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:35467934G>T	ENST00000381151.3	+	2	949	c.437G>T	c.(436-438)gGt>gTt	p.G146V	MRPS6_ENST00000399312.2_Intron	NM_006933.4	NP_008864.3	P53794	SC5A3_HUMAN	solute carrier family 5 (sodium/myo-inositol cotransporter), member 3	146						integral to plasma membrane	myo-inositol:sodium symporter activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	20						CTGTATTCGGGTGCCCTTTTT	0.468000													95	107					2.26018e-36	3.56585e-36	0.323286	1	0
ZNF99	7652	broad.mit.edu	37	19	22941809	22941809	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:22941809G>A	ENST00000397104.3	-	5	628	c.629C>T	c.(628-630)aCt>aTt	p.T210I	ZNF99_ENST00000596209.1_Missense_Mutation_p.T301I					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTTATGTCTAGTAAGGTGTGA	0.353000													13	119					0	0	0.119110	0	0
MUC15	143662	broad.mit.edu	37	11	26584732	26584732	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:26584732A>G	ENST00000436318.2	-	3	989	c.856T>C	c.(856-858)Ttg>Ctg	p.L286L	MUC15_ENST00000281268.8_Intron|MUC15_ENST00000527569.1_Intron|MUC15_ENST00000529533.1_Silent_p.L286L|ANO3_ENST00000531568.1_Intron|ANO3_ENST00000525139.1_Intron|ANO3_ENST00000529242.1_3'UTR|MUC15_ENST00000455601.2_Silent_p.L259L|ANO3_ENST00000537978.1_Intron|ANO3_ENST00000256737.3_Intron			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	259						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						CCACACAACAAGTAGCCCACA	0.388000													18	191					0	0	0.219247	0	0
CSMD1	64478	broad.mit.edu	37	8	3046430	3046430	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:3046430A>T	ENST00000520002.1	-	36	6060	c.5505T>A	c.(5503-5505)gtT>gtA	p.V1835V	CSMD1_ENST00000542608.1_Silent_p.V1834V|CSMD1_ENST00000539096.1_Silent_p.V1834V|CSMD1_ENST00000537824.1_Silent_p.V1834V|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000602723.1_Silent_p.V1835V|CSMD1_ENST00000400186.3_Silent_p.V1835V|CSMD1_ENST00000602557.1_Silent_p.V1835V			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1835	CUB 11.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGCCCTCCGTAACTATGATCT	0.488000													8	1					0	0	0.278610	0	0
ZNF99	7652	broad.mit.edu	37	19	22939747	22939747	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:22939747C>A	ENST00000397104.3	-	6	2583	c.2584G>T	c.(2584-2586)Gaa>Taa	p.E862*						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTACCACATTCTTCACATTTG	0.353000													27	91					1.2476e-16	1.59201e-16	0.116897	1	0
RNF175	285533	broad.mit.edu	37	4	154669893	154669893	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:154669893G>T	ENST00000347063.4	-	3	522	c.150C>A	c.(148-150)tcC>tcA	p.S50S	RNF175_ENST00000506505.1_5'UTR|RNF175_ENST00000274068.4_5'UTR	NM_173662.2	NP_775933.1	Q8N4F7	RN175_HUMAN	ring finger protein 175	50						integral to membrane	zinc ion binding			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	13	all_hematologic(180;0.093)	Renal(120;0.118)				CCACGTGCATGGAATCGTGGC	0.517000													9	9					2.74318e-10	3.14886e-10	0.058154	1	0
TIAM1	7074	broad.mit.edu	37	21	32617896	32617896	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:32617896C>A	ENST00000286827.3	-	7	1963	c.1492G>T	c.(1492-1494)Gag>Tag	p.E498*	TIAM1_ENST00000469412.1_5'UTR|TIAM1_ENST00000541036.1_Nonsense_Mutation_p.E498*	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	498	PH 1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						ATGCTGTTCTCCACCCAGACG	0.542000													64	57					3.36121e-32	5.13803e-32	0.323286	1	0
SH3GLB1	51100	broad.mit.edu	37	1	87181526	87181526	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:87181526A>G	ENST00000370558.4	+	2	516	c.192A>G	c.(190-192)gaA>gaG	p.E64E	SH3GLB1_ENST00000535010.1_Intron|SH3GLB1_ENST00000482504.1_Silent_p.E64E	NM_001206651.1|NM_001206653.1|NM_016009.4	NP_001193580.1|NP_001193582.1|NP_057093.1	Q9Y371	SHLB1_HUMAN	SH3-domain GRB2-like endophilin B1	64	BAR.				anti-apoptosis|filopodium assembly|signal transduction	Golgi membrane|mitochondrial outer membrane	cytoskeletal adaptor activity|protein homodimerization activity|SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|stomach(1)	11		Lung NSC(277;0.209)		all cancers(265;0.0136)|Epithelial(280;0.0414)		AACAAACTGAAGTGTTATTGC	0.353000													22	72					0	0	0.249174	0	0
CES5A	221223	broad.mit.edu	37	16	55890296	55890296	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:55890296T>G	ENST00000521992.1	-	10	1350	c.1205A>C	c.(1204-1206)aAc>aCc	p.N402T	CES5A_ENST00000520435.1_Missense_Mutation_p.N343T|CES5A_ENST00000290567.9_Missense_Mutation_p.N373T|CES5A_ENST00000518005.1_Missense_Mutation_p.N267T|CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000319165.9_Missense_Mutation_p.N373T	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	373						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						CACCAGGATGTTTTGTATCAG	0.537000													61	191					0	0	0.323286	0	0
BOLL	66037	broad.mit.edu	37	2	198636675	198636675	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:198636675C>A	ENST00000321801.7	-	6	990	c.420G>T	c.(418-420)atG>atT	p.M140I	AC011997.1_ENST00000409845.1_Intron|BOLL_ENST00000392296.4_Missense_Mutation_p.M128I|BOLL_ENST00000282278.8_Missense_Mutation_p.M19I|BOLL_ENST00000433157.1_Missense_Mutation_p.M128I|BOLL_ENST00000430004.1_Missense_Mutation_p.M128I	NM_197970.2	NP_932074.1	Q8N9W6	BOLL_HUMAN	boule-like RNA-binding protein	128					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(3)|prostate(1)	13						TTGTTAGATACATTGTTCCAG	0.338000													11	84					1.08611e-07	1.19026e-07	0.080935	1	0
UNC13A	23025	broad.mit.edu	37	19	17756509	17756509	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:17756509C>A	ENST00000428389.2	-	20	2593	c.2594G>T	c.(2593-2595)gGc>gTc	p.G865V	UNC13A_ENST00000550896.1_Missense_Mutation_p.G775V|UNC13A_ENST00000552293.1_Missense_Mutation_p.G777V|UNC13A_ENST00000551649.1_Missense_Mutation_p.G777V|UNC13A_ENST00000519716.2_Missense_Mutation_p.G777V|UNC13A_ENST00000252773.7_Missense_Mutation_p.G777V			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	777					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						GTCCATCTCGCCGCTGAGCGT	0.587000													35	48					8.16277e-20	1.08919e-19	0.246493	1	0
GJC1	10052	broad.mit.edu	37	17	42883060	42883060	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:42883060G>A	ENST00000426548.1	-	3	395	c.126C>T	c.(124-126)tcC>tcT	p.S42S	GJC1_ENST00000330514.4_Silent_p.S42S|GJC1_ENST00000592524.1_Silent_p.S42S|GJC1_ENST00000590758.1_Silent_p.S42S	NM_001080383.1|NM_005497.3	NP_001073852.1|NP_005488.2	P36383	CXG1_HUMAN	gap junction protein, gamma 1, 45kDa	42					cellular membrane organization|gap junction assembly|muscle contraction|synaptic transmission|transport	connexon complex|integral to membrane				NS(1)|kidney(1)|large_intestine(5)|liver(1)|lung(10)|prostate(1)	19		Prostate(33;0.0959)				CGTAATAGATGGATTCTCCTC	0.473000													28	57					0	0	0.116897	0	0
RB1CC1	9821	broad.mit.edu	37	8	53573763	53573763	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:53573763C>A	ENST00000025008.5	-	10	1960	c.1437G>T	c.(1435-1437)ctG>ctT	p.L479L	RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Silent_p.L479L|RB1CC1_ENST00000539297.1_Silent_p.L479L	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	479					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CTCTTTCTAACAGCTCTATTA	0.373000													28	52					3.65163e-15	4.56196e-15	0.116897	1	0
TMTC4	84899	broad.mit.edu	37	13	101287161	101287161	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:101287161G>A	ENST00000342624.5	-	12	1662	c.1404C>T	c.(1402-1404)atC>atT	p.I468I	TMTC4_ENST00000328767.5_Silent_p.I338I|TMTC4_ENST00000376234.3_Silent_p.I449I|TMTC4_ENST00000462211.1_5'UTR	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	449						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TGATGAATAAGATTCCCAGCA	0.502000													50	254					0	0	0.323286	0	0
SH3BP4	23677	broad.mit.edu	37	2	235951538	235951538	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:235951538G>T	ENST00000409212.1	+	4	2632	c.2125G>T	c.(2125-2127)Ggc>Tgc	p.G709C	SH3BP4_ENST00000392011.2_Missense_Mutation_p.G709C|SH3BP4_ENST00000344528.4_Missense_Mutation_p.G709C			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	709					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CTACTACCAGGGCAGGGTGGG	0.687000													8	60					0.000274275	0.000286389	0.307466	1	0
TLN2	83660	broad.mit.edu	37	15	63055787	63055787	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:63055787T>C	ENST00000561311.1	+	39	5217	c.4987T>C	c.(4987-4989)Tgt>Cgt	p.C1663R	TLN2_ENST00000472902.1_Missense_Mutation_p.C56R|TLN2_ENST00000306829.6_Missense_Mutation_p.C1663R			Q9Y4G6	TLN2_HUMAN	talin 2	1663					cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						ACAGAGGGAGTGTGATTACTC	0.627000													25	121					0	0	0.125774	0	0
SLC6A9	6536	broad.mit.edu	37	1	44476399	44476399	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:44476399T>A	ENST00000372310.3	-	3	351	c.187_splice	c.e3+1	p.G62_splice	SLC6A9_ENST00000372306.3_Splice_Site_p.G62_splice|SLC6A9_ENST00000537678.1_Intron|SLC6A9_ENST00000492434.2_Intron|SLC6A9_ENST00000372307.3_5'UTR|SLC6A9_ENST00000475075.2_Intron|SLC6A9_ENST00000357730.2_Splice_Site_p.G81_splice|SLC6A9_ENST00000360584.2_Splice_Site_p.G135_splice	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	135						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	ACTGGGTACCTCCCCCGTTGC	0.632000													15	32					0	0	0.160694	0	0
SYT16	83851	broad.mit.edu	37	14	62463151	62463151	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:62463151T>G	ENST00000430451.2	+	1	611	c.414T>G	c.(412-414)tcT>tcG	p.S138S	SYT16_ENST00000446982.2_Silent_p.S138S	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	138										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		ATGTGCTTTCTTCTATTGCGG	0.483000													193	518					0	0	0.323286	0	0
TMEM132D	121256	broad.mit.edu	37	12	129566496	129566496	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:129566496C>G	ENST00000422113.2	-	7	2057	c.1731G>C	c.(1729-1731)gtG>gtC	p.V577V	TMEM132D_ENST00000389441.4_Silent_p.V115V	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	577						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TCAGGACCCGCACCATGGCGT	0.652000													26	14					0	0	0.183431	0	0
NPC1L1	29881	broad.mit.edu	37	7	44560418	44560418	+	Splice_Site	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:44560418C>T	ENST00000289547.4	-	14	3137	c.3080_splice	c.e14-1	p.G1028_splice	NPC1L1_ENST00000381160.3_Splice_Site_p.G1028_splice|NPC1L1_ENST00000546276.1_Splice_Site_p.G982_splice	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	1028					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	GCTGCCAGGCCGCTGCAAGAA	0.572000													16	257					0	0	0.175082	0	0
CDH17	1015	broad.mit.edu	37	8	95186160	95186160	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:95186160C>A	ENST00000027335.3	-	7	772	c.648G>T	c.(646-648)atG>atT	p.M216I	CDH17_ENST00000441892.2_Intron|CDH17_ENST00000450165.2_Missense_Mutation_p.M216I	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	216	Cadherin 2.					integral to membrane	calcium ion binding	p.M216I(1)		NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TCTGGCCTCCCATGTCCTTCA	0.443000													19	43					2.4624e-09	2.77512e-09	0.204396	1	0
MED12	9968	broad.mit.edu	37	X	70354970	70354970	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:70354970G>T	ENST00000333646.6	+	36	5091	c.4892G>T	c.(4891-4893)aGt>aTt	p.S1631I	MED12_ENST00000374080.3_Missense_Mutation_p.S1631I|MED12_ENST00000374102.1_Missense_Mutation_p.S1631I|MED12_ENST00000478889.1_Intron	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	1631	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					CAGTCAGACAGTCTGGAAAAG	0.562000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						93	8					4.09449e-47	6.80657e-47	0.323286	1	0
ANKHD1	54882	broad.mit.edu	37	5	139907771	139907771	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:139907771G>T	ENST00000297183.6	+	29	5364	c.5240G>T	c.(5239-5241)gGt>gTt	p.G1747V	ANKHD1_ENST00000544120.1_Missense_Mutation_p.G130V|ANKHD1-EIF4EBP3_ENST00000532219.1_Missense_Mutation_p.G1747V|ANKHD1_ENST00000360839.2_Missense_Mutation_p.G1747V	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			tCCCTTAGGGGTGGCACAGAA	0.313000													35	43					3.76114e-14	4.63704e-14	0.203993	1	0
NRP2	8828	broad.mit.edu	37	2	206659529	206659529	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:206659529G>T	ENST00000360409.3	+	17	3334	c.2543G>T	c.(2542-2544)gGc>gTc	p.G848V	NRP2_ENST00000540178.1_Missense_Mutation_p.G843V|NRP2_ENST00000412873.2_Missense_Mutation_p.G826V|NRP2_ENST00000540841.1_Missense_Mutation_p.G826V|NRP2_ENST00000357785.5_Missense_Mutation_p.G843V	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	848					angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						TCAGGGTCTGGCGCCCCCTCG	0.547000													49	152					6.4308e-24	9.04459e-24	0.323286	1	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95481179	95481179	+	RNA	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:95481179A>G	ENST00000432432.2	-	0	2181					NR_040113.1																						TTCTAAAGCCAATGACTTTTT	0.323000													66	111					0	0	0.323286	0	0
ANKRD7	56311	broad.mit.edu	37	7	117874591	117874591	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:117874591T>A	ENST00000357099.4	+	3	519	c.346T>A	c.(346-348)Ttg>Atg	p.L116M	ANKRD7_ENST00000417525.1_Missense_Mutation_p.L43M|ANKRD7_ENST00000477532.1_3'UTR|ANKRD7_ENST00000265224.4_Missense_Mutation_p.L96M|ANKRD7_ENST00000433239.1_Missense_Mutation_p.L43M			Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	96					male gonad development					breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)	29						CAAATCCCCATTGATTAAGGT	0.323000													40	78					0	0	0.246493	0	0
COL6A3	1293	broad.mit.edu	37	2	238289978	238289978	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:238289978C>A	ENST00000295550.4	-	5	1929	c.1477G>T	c.(1477-1479)Gtg>Ttg	p.V493L	COL6A3_ENST00000346358.4_Missense_Mutation_p.V493L|COL6A3_ENST00000392004.3_Missense_Mutation_p.V287L|COL6A3_ENST00000472056.1_Missense_Mutation_p.V86L|COL6A3_ENST00000409809.1_Missense_Mutation_p.V287L|COL6A3_ENST00000392003.2_Missense_Mutation_p.V86L|COL6A3_ENST00000347401.3_Missense_Mutation_p.V292L|COL6A3_ENST00000353578.4_Missense_Mutation_p.V287L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	493	Nonhelical region.|VWFA 3.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		TCAGGCCTCACAGTGTCTGCA	0.507000													121	317					1.31343e-73	2.34448e-73	0.323286	1	0
L2HGDH	79944	broad.mit.edu	37	14	50735895	50735895	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:50735895C>A	ENST00000267436.4	-	7	1289	c.892G>T	c.(892-894)Gga>Tga	p.G298*	L2HGDH_ENST00000261699.4_Nonsense_Mutation_p.G298*|L2HGDH_ENST00000421284.3_Nonsense_Mutation_p.G298*			Q9H9P8	L2HDH_HUMAN	L-2-hydroxyglutarate dehydrogenase	298					2-oxoglutarate metabolic process|cellular protein metabolic process	integral to mitochondrial inner membrane	2-hydroxyglutarate dehydrogenase activity			kidney(1)|large_intestine(4)|lung(3)|ovary(2)	10	all_epithelial(31;0.000599)|Breast(41;0.0102)					TAAATATTTCCTTTTACAAGA	0.408000													93	111					1.07466e-44	1.77222e-44	0.323286	1	0
ZCCHC13	389874	broad.mit.edu	37	X	73524209	73524209	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:73524209T>C	ENST00000339534.2	+	1	185	c.108T>C	c.(106-108)tcT>tcC	p.S36S		NM_203303.2	NP_976048.1	Q8WW36	ZCH13_HUMAN	zinc finger, CCHC domain containing 13	36							nucleic acid binding|zinc ion binding			breast(1)|kidney(1)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	8						GCAGAGGTTCTCAATGTGGTT	0.542000													20	21					0	0	0.249174	0	0
ZNF876P	642280	broad.mit.edu	37	4	206433	206433	+	RNA	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:206433G>C	ENST00000356347.3	+	0	35					NR_027481.1																						AGCTCGGTTAGGGCCTCACCG	0.632000													5	13					0	0	0.058154	0	0
RREB1	6239	broad.mit.edu	37	6	7231129	7231129	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:7231129G>T	ENST00000379938.2	+	10	3334	c.2797G>T	c.(2797-2799)Gag>Tag	p.E933*	RREB1_ENST00000349384.6_Nonsense_Mutation_p.E933*|RREB1_ENST00000379933.3_Nonsense_Mutation_p.E933*|RREB1_ENST00000334984.6_Nonsense_Mutation_p.E933*	NM_001003699.3|NM_001003700.1	NP_001003699.1|NP_001003700.1	Q92766	RREB1_HUMAN	ras responsive element binding protein 1	933					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(18)|ovary(5)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CTGCTCCATGGAGCCCATCGA	0.587000													24	57					5.35356e-11	6.23307e-11	0.264190	1	0
GBP7	388646	broad.mit.edu	37	1	89637451	89637451	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:89637451G>T	ENST00000294671.2	-	2	306	c.168C>A	c.(166-168)aaC>aaA	p.N56K		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	56						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		CAGCCAGCTTGTTCATTAGGT	0.488000													50	153					7.50695e-29	1.10868e-28	0.323286	1	0
CHD6	84181	broad.mit.edu	37	20	40102043	40102043	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:40102043C>A	ENST00000373233.3	-	17	2760	c.2583G>T	c.(2581-2583)gcG>gcT	p.A861A	CHD6_ENST00000309279.7_Intron	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	861	Helicase C-terminal.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding	p.A861A(1)		breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				CCAGGCCTCCCGCTCTGGTGC	0.517000													37	129					6.70999e-13	8.07022e-13	0.203993	1	0
PIK3CG	5294	broad.mit.edu	37	7	106509636	106509636	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:106509636C>A	ENST00000359195.3	+	2	1940	c.1630C>A	c.(1630-1632)Cga>Aga	p.R544R	PIK3CG_ENST00000440650.2_Silent_p.R544R|PIK3CG_ENST00000496166.1_Silent_p.R544R	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	544					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						GGACCGGGTTCGAGCAGAAAT	0.542000													27	88					1.77063e-15	2.22822e-15	0.324025	1	0
FOXP2	93986	broad.mit.edu	37	7	114298122	114298122	+	Splice_Site	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:114298122T>G	ENST00000408937.3	+	12	1717	c.1341_splice	c.e12-1	p.L448_splice	FOXP2_ENST00000393498.2_Splice_Site_p.L402_splice|FOXP2_ENST00000393489.3_Splice_Site_p.L331_splice|FOXP2_ENST00000393491.3_Intron|FOXP2_ENST00000350908.4_Splice_Site_p.L423_splice|FOXP2_ENST00000393500.3_3'UTR|FOXP2_ENST00000393494.2_Splice_Site_p.L423_splice|FOXP2_ENST00000403559.4_Splice_Site_p.L440_splice	NM_001172766.2|NM_014491.3|NM_148898.3	NP_001166237.1|NP_055306.1|NP_683696.2	O15409	FOXP2_HUMAN	forkhead box P2	423					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						CCTTTGCAGCTAAATCTGGTG	0.478000													8	222					0	0	0.069234	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186916013	186916013	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:186916013G>T	ENST00000367466.3	+	12	1336	c.1184G>T	c.(1183-1185)aGt>aTt	p.S395I	PLA2G4A_ENST00000442353.2_Missense_Mutation_p.S335I	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	395	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	GTCTGGGGCAGTGCCTTTTCC	0.353000													133	87					3.75716e-53	6.4216e-53	0.323286	1	0
TTN	7273	broad.mit.edu	37	2	179443955	179443955	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179443955G>C	ENST00000589042.1	-	320	68026	c.67802C>G	c.(67801-67803)tCa>tGa	p.S22601*	TTN_ENST00000342175.6_Nonsense_Mutation_p.S13728*|TTN_ENST00000359218.5_Nonsense_Mutation_p.S13661*|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.S20960*|TTN_ENST00000460472.2_Nonsense_Mutation_p.S13536*|RP11-171I2.2_ENST00000603521.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.S20033*|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20960	Fibronectin type-III 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACCGCAGATGACTCAACACT	0.448000													42	174					0	0	0.323286	0	0
RELN	5649	broad.mit.edu	37	7	103338364	103338364	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:103338364A>G	ENST00000424685.2	-	10	1238	c.1079T>C	c.(1078-1080)tTa>tCa	p.L360S	RELN_ENST00000428762.1_Missense_Mutation_p.L360S|RELN_ENST00000343529.5_Missense_Mutation_p.L360S			P78509	RELN_HUMAN	reelin	360					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACTATCTTCTAAAACGACTTG	0.433000													83	247					0	0	0.323286	0	0
TRPM2	7226	broad.mit.edu	37	21	45774530	45774530	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:45774530G>T	ENST00000397928.1	+	2	610		c.e2-1		TRPM2_ENST00000300482.5_Splice_Site|TRPM2_ENST00000397932.2_Splice_Site|TRPM2_ENST00000300481.9_Splice_Site	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2							integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TTTACCTTCAGCAAGAAAGCC	0.458000													20	37					2.54575e-18	3.32245e-18	0.219247	1	0
IGKV1-8	28942	broad.mit.edu	37	2	89291948	89291948	+	RNA	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:89291948G>C	ENST00000495489.1	-	0	377																											TAATACTGTTGACAGTAATAA	0.507000													31	212					0	0	0.214465	0	0
TNFSF4	7292	broad.mit.edu	37	1	173155714	173155714	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:173155714C>A	ENST00000281834.3	-	3	629	c.493G>T	c.(493-495)Gtg>Ttg	p.V165L	TNFSF4_ENST00000367718.1_Missense_Mutation_p.V115L	NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	165					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						CCGCCATTCACATGGAAGTCA	0.463000													67	108					1.14856e-27	1.67472e-27	0.323286	1	0
TENM2	57451	broad.mit.edu	37	5	167671430	167671430	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:167671430T>C	ENST00000519204.1	+	25	5281	c.5163T>C	c.(5161-5163)caT>caC	p.H1721H	TENM2_ENST00000518659.1_Silent_p.H1842H|TENM2_ENST00000520394.1_Silent_p.H1603H|TENM2_ENST00000403607.2_Silent_p.H1666H|TENM2_ENST00000545108.1_Silent_p.H1841H					teneurin transmembrane protein 2																		CCTAGGTCCATGGAAGAAATC	0.483000													8	23					0	0	0.278610	0	0
KRTAP4-2	85291	broad.mit.edu	37	17	39334404	39334404	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39334404A>T	ENST00000377726.2	-	1	56	c.13T>A	c.(13-15)Tgt>Agt	p.C5S		NM_033062.3	NP_149051.1	Q9BYR5	KRA42_HUMAN	keratin associated protein 4-2	5	20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]- [VSTQ].					keratin filament				kidney(2)|lung(4)|upper_aerodigestive_tract(1)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			GAGCCACAACAGGAGTTGACC	0.582000													44	112					0	0	0.323286	0	0
OLFML2A	169611	broad.mit.edu	37	9	127572311	127572311	+	Missense_Mutation	SNP	G	G	A	rs140626253	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:127572311G>A	ENST00000373580.3	+	8	1579	c.1579G>A	c.(1579-1581)Gag>Aag	p.E527K	OLFML2A_ENST00000288815.5_Missense_Mutation_p.E313K	NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	527	Olfactomedin-like.									endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						TGCCGTGGACGAGAGCGGCCT	0.657000													14	9					0	0	0.132662	0	0
TEX37	200523	broad.mit.edu	37	2	88828648	88828648	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:88828648G>T	ENST00000303254.3	+	4	341	c.199G>T	c.(199-201)Ggg>Tgg	p.G67W		NM_152670.2	NP_689883.1			testis expressed 37																		GCTAACAGATGGGTACCCTGC	0.547000													42	69					2.47872e-24	3.50051e-24	0.290176	1	0
ZNF14	7561	broad.mit.edu	37	19	19824950	19824950	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19824950C>A	ENST00000344099.3	-	3	279	c.141G>T	c.(139-141)tgG>tgT	p.W47C		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	47	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				CCTGGTCTTCCCACTTTTTTC	0.378000													74	28					2.84844e-50	4.79696e-50	0.323286	1	0
ELSPBP1	64100	broad.mit.edu	37	19	48523048	48523048	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:48523048G>T	ENST00000339841.2	+	5	606	c.428G>T	c.(427-429)tGc>tTc	p.C143F	ELSPBP1_ENST00000597519.1_Intron	NM_022142.4	NP_071425.3	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1	143	Fibronectin type-II 3.				single fertilization	extracellular region				NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(6)	10		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		GTCTCTGATTGCATGGAGGAT	0.478000													27	69					2.48779e-11	2.92066e-11	0.324025	1	0
TNFRSF4	7293	broad.mit.edu	37	1	1147505	1147505	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:1147505C>A	ENST00000379236.3	-	5	455	c.451G>T	c.(451-453)Ggg>Tgg	p.G151W	TNFRSF4_ENST00000453580.1_5'UTR	NM_003327.3	NP_003318.1	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily, member 4	151					immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity			large_intestine(1)|lung(2)|urinary_tract(1)	4	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		GTGTGCTTCCCAGCCAAGGTG	0.677000													9	6					7.48243e-07	8.1252e-07	0.058154	1	0
SLC6A2	6530	broad.mit.edu	37	16	55725950	55725950	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:55725950T>A	ENST00000379906.2	+	5	1159	c.904T>A	c.(904-906)Ttg>Atg	p.L302M	SLC6A2_ENST00000567238.1_Missense_Mutation_p.L197M|SLC6A2_ENST00000568943.1_Missense_Mutation_p.L302M|SLC6A2_ENST00000566163.1_Intron|SLC6A2_ENST00000414754.3_Missense_Mutation_p.L302M|SLC6A2_ENST00000561820.1_Missense_Mutation_p.L302M|SLC6A2_ENST00000219833.8_Missense_Mutation_p.L302M	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	302					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	CTTCTACCGCTTGAAAGAGGC	0.577000													64	110					0	0	0.323286	0	0
TTYH2	94015	broad.mit.edu	37	17	72248390	72248390	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:72248390T>A	ENST00000441391.2	+	5	1383	c.171T>A	c.(169-171)ctT>ctA	p.L57L	TTYH2_ENST00000529107.1_Silent_p.L357L|TTYH2_ENST00000269346.4_Silent_p.L378L	NM_052869.1	NP_443101.1	Q9BSA4	TTYH2_HUMAN	tweety family member 2	378						chloride channel complex|plasma membrane	chloride channel activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(14)|ovary(3)|pancreas(1)|stomach(3)|upper_aerodigestive_tract(1)	36						TGGACGCTCTTGCTGGCATCT	0.617000													73	164					0	0	0.323286	0	0
BTAF1	9044	broad.mit.edu	37	10	93711234	93711234	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:93711234G>T	ENST00000265990.6	+	5	783	c.475G>T	c.(475-477)Gaa>Taa	p.E159*		NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	159					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				TAATATGGGAGAAGCAATTGG	0.368000													28	44					1.75199e-13	2.13031e-13	0.125774	1	0
NYNRIN	57523	broad.mit.edu	37	14	24879320	24879320	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:24879320G>T	ENST00000382554.3	+	4	2638	c.2320G>T	c.(2320-2322)Gcc>Tcc	p.A774S		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	774					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						GTACCACGAGGCCCTGAATAC	0.632000													42	169					1.35964e-18	1.78197e-18	0.323286	1	0
RCVRN	5957	broad.mit.edu	37	17	9808315	9808315	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:9808315G>T	ENST00000226193.5	-	1	623	c.183C>A	c.(181-183)gaC>gaA	p.D61E		NM_002903.2	NP_002894.1	P35243	RECO_HUMAN	recoverin	61	EF-hand 2.				visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|upper_aerodigestive_tract(1)	12						AGGCCTTGGGGTCGGTGTCGG	0.607000													28	34					3.1745e-13	3.8434e-13	0.134883	1	0
SYNE2	23224	broad.mit.edu	37	14	64476712	64476712	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:64476712C>A	ENST00000358025.3	+	32	4836	c.4606C>A	c.(4606-4608)Ctc>Atc	p.L1536I	SYNE2_ENST00000554584.1_Missense_Mutation_p.L1536I|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.L1536I	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1536					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTTTTGGAGCTCTTAAAACA	0.348000													10	122					7.48243e-07	8.1252e-07	0.058154	1	0
TIMP1	7076	broad.mit.edu	37	X	47445945	47445945	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:47445945G>A	ENST00000218388.4	+	6	649	c.479G>A	c.(478-480)tGc>tAc	p.C160Y	TIMP1_ENST00000377017.1_Missense_Mutation_p.C96Y|SYN1_ENST00000295987.7_Intron|SYN1_ENST00000340666.4_Intron	NM_003254.2	NP_003245.1	P01033	TIMP1_HUMAN	TIMP metallopeptidase inhibitor 1	160					erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(1)|large_intestine(2)	3						TCCATCCCCTGCAAACTGCAG	0.592000													54	3					0	0	0.323286	0	0
MAGEB4	4115	broad.mit.edu	37	X	30261047	30261047	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:30261047C>A	ENST00000378982.2	+	1	991	c.795C>A	c.(793-795)ccC>ccA	p.P265P		NM_002367.3	NP_002358.1	O15481	MAGB4_HUMAN	melanoma antigen family B, 4	265	MAGE.									breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	27						ACAGTGATCCCCCACGCTATC	0.498000													35	46					1.836e-18	2.3992e-18	0.193644	1	0
DEPTOR	64798	broad.mit.edu	37	8	120977584	120977584	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:120977584G>T	ENST00000286234.5	+	4	668	c.538G>T	c.(538-540)Gcc>Tcc	p.A180S	DEPTOR_ENST00000523492.1_Missense_Mutation_p.A79S	NM_022783.2	NP_073620.2	Q8TB45	DPTOR_HUMAN	DEP domain containing MTOR-interacting protein	180	DEP 2.				intracellular signal transduction|negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|regulation of apoptosis	intracellular	protein binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	18						GGAAGGTGAGGCCACCACGAG	0.557000													20	29					1.33834e-09	1.51548e-09	0.189662	1	0
TAGAP	117289	broad.mit.edu	37	6	159459194	159459194	+	Missense_Mutation	SNP	G	G	T	rs112913154	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:159459194G>T	ENST00000367066.3	-	9	1181	c.850C>A	c.(850-852)Cat>Aat	p.H284N	RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000606466.1_RNA|TAGAP_ENST00000326965.6_Missense_Mutation_p.H106N|RP1-111C20.4_ENST00000607391.1_RNA|RP1-111C20.4_ENST00000606470.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	284					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		ATACTGGAATGCACTGGAATG	0.418000													57	189					6.70656e-16	8.48803e-16	0.323286	1	0
ZPLD1	131368	broad.mit.edu	37	3	102196310	102196310	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:102196310C>T	ENST00000306176.1	+	11	1244	c.1144C>T	c.(1144-1146)Cag>Tag	p.Q382*	ZPLD1_ENST00000491959.1_Nonsense_Mutation_p.Q366*|ZPLD1_ENST00000466937.1_Nonsense_Mutation_p.Q366*	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	366						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GCCTCCCTTCCAGCTGAACGC	0.463000													220	452					0	0	0.323286	0	0
GH2	2689	broad.mit.edu	37	17	61958487	61958487	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:61958487C>A	ENST00000332800.7	-	3	326	c.193G>T	c.(193-195)Gag>Tag	p.E65*	GH2_ENST00000456543.2_Nonsense_Mutation_p.E65*|GH2_ENST00000449787.2_Intron|GH2_ENST00000423893.2_Nonsense_Mutation_p.E65*	NM_002059.4|NM_022557.3|NM_022558.3	NP_002050.1|NP_072051.1|NP_072052.1	P01242	SOM2_HUMAN	growth hormone 2	65						extracellular region	hormone activity			breast(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	24						TACTTCTGCTCCTTCAGGATA	0.507000													98	218					3.91642e-63	6.89549e-63	0.323286	1	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95488809	95488809	+	RNA	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:95488809T>G	ENST00000432432.2	-	0	1204					NR_040113.1																						AAGCCACTGGTAAGGCTTGTT	0.313000													76	65					0	0	0.323286	0	0
ARID1A	8289	broad.mit.edu	37	1	27088771	27088771	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:27088771G>A	ENST00000324856.7	+	7	2751	c.2380G>A	c.(2380-2382)Ggg>Agg	p.G794R	ARID1A_ENST00000457599.2_Missense_Mutation_p.G794R|ARID1A_ENST00000374152.2_Missense_Mutation_p.G411R	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	794					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GAACTCCATGGGGAGCTATGG	0.572000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								39	83					0	0	0.257332	0	0
OR6N1	128372	broad.mit.edu	37	1	158736274	158736274	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158736274A>G	ENST00000335094.2	-	1	218	c.199T>C	c.(199-201)Tcc>Ccc	p.S67P		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					TCTGAGAAGGAGAGAATGCTG	0.498000													5	345					0	0	0.248553	0	0
MS4A6E	245802	broad.mit.edu	37	11	60102465	60102465	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:60102465G>A	ENST00000300182.4	+	1	162	c.97G>A	c.(97-99)Ggg>Agg	p.G33R		NM_139249.2	NP_640342.1	Q96DS6	M4A6E_HUMAN	membrane-spanning 4-domains, subfamily A, member 6E	33						integral to membrane	receptor activity			endometrium(2)|kidney(1)|lung(9)|stomach(1)	13						CACCAACCAGGGGCAGGATAG	0.448000													82	51					0	0	0.323286	0	0
CDH3	1001	broad.mit.edu	37	16	68713832	68713832	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:68713832G>T	ENST00000264012.4	+	7	1366	c.822G>T	c.(820-822)cgG>cgT	p.R274R	CDH3_ENST00000581171.1_Silent_p.R219R|CDH3_ENST00000429102.2_Silent_p.R274R	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	274	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		CCATTCACCGGAGCACAGGCA	0.552000													85	4					5.42582e-32	8.2655e-32	0.323286	1	0
ATP13A4	84239	broad.mit.edu	37	3	193158420	193158420	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:193158420T>A	ENST00000342695.4	-	21	2768	c.2446A>T	c.(2446-2448)Atc>Ttc	p.I816F	ATP13A4_ENST00000392443.3_Missense_Mutation_p.I797F	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	816					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		GTCCCATTGATCAATATCTGT	0.408000													18	92					0	0	0.189662	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455389	84455389	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:84455389A>G	ENST00000377084.2	-	1	1139	c.254T>C	c.(253-255)gTt>gCt	p.V85A		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	85						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GTGCAAACTAACCGCATTATA	0.458000													22	85					0	0	0.125774	0	0
EXO5	64789	broad.mit.edu	37	1	40980948	40980948	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:40980948G>A	ENST00000372703.1	+	2	1806	c.732G>A	c.(730-732)ttG>ttA	p.L244L	EXO5_ENST00000358527.2_Silent_p.L244L|EXO5_ENST00000296380.4_Silent_p.L244L					exonuclease 5																		ACACAAAGTTGTGTCTAGAAA	0.468000													44	99					0	0	0.323286	0	0
NOP16	51491	broad.mit.edu	37	5	175811206	175811206	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:175811206C>G	ENST00000510123.1	-	5	694	c.472G>C	c.(472-474)Gct>Cct	p.A158P	NOP16_ENST00000389158.5_3'UTR|NOP16_ENST00000507413.1_Missense_Mutation_p.R63S	NM_001256539.1|NM_001256540.1|NM_016391.5	NP_001243468.1|NP_001243469.1|NP_057475.2	Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein	0						nucleolus				central_nervous_system(1)|endometrium(2)|lung(4)|ovary(1)	8						GACGCCTCAGCCTGGGGCAGC	0.562000													14	25					0	0	0.132662	0	0
NRXN1	9378	broad.mit.edu	37	2	50847201	50847201	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:50847201C>A	ENST00000404971.1	-	9	2738	c.1399G>T	c.(1399-1401)Ggg>Tgg	p.G467W	NRXN1_ENST00000402717.3_Missense_Mutation_p.G419W|NRXN1_ENST00000406316.2_Missense_Mutation_p.G427W|NRXN1_ENST00000405472.3_Missense_Mutation_p.G419W|NRXN1_ENST00000401669.2_Missense_Mutation_p.G427W|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406859.3_Missense_Mutation_p.G427W	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	427	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTGGTGACCCTGGAAGGTCG	0.458000													35	34					7.05121e-23	9.81465e-23	0.290176	1	0
OR5L1	219437	broad.mit.edu	37	11	55579717	55579717	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55579717T>C	ENST00000333973.2	+	1	864	c.775T>C	c.(775-777)Tat>Cat	p.Y259H		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				CCTTTCCATTTATTGCAGGCC	0.517000													58	108					0	0	0.323286	0	0
FAM91A1	157769	broad.mit.edu	37	8	124820580	124820580	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:124820580G>A	ENST00000334705.7	+	21	2347	c.2101G>A	c.(2101-2103)Gaa>Aaa	p.E701K	FAM91A1_ENST00000521166.1_Missense_Mutation_p.E701K	NM_144963.2	NP_659400.2	Q658Y4	F91A1_HUMAN	family with sequence similarity 91, member A1	701										breast(4)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			GGTCATTGAGGAAGCAACTAT	0.343000													52	60					0	0	0.323286	0	0
RSF1	51773	broad.mit.edu	37	11	77402204	77402204	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:77402204C>A	ENST00000308488.6	-	9	3202	c.2900_splice	c.e9+1	p.R967_splice	RSF1_ENST00000480887.1_Splice_Site_p.R715_splice|RSF1_ENST00000360355.2_Splice_Site_p.R936_splice			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	967					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			ATAAAAATACCTTCGTTCGGC	0.363000													44	36					5.39261e-20	7.21422e-20	0.323286	1	0
GABRQ	55879	broad.mit.edu	37	X	151821226	151821226	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:151821226C>T	ENST00000370306.2	+	9	1401	c.1381C>T	c.(1381-1383)Cgg>Tgg	p.R461W		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	461						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGCAGGCCCGGCACAGCTA	0.577000													109	5					0	0	0.323286	0	0
PTEN	5728	broad.mit.edu	37	10	89685269	89685269	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:89685269G>T	ENST00000371953.3	+	3	1521		c.e3-1			NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog						activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(10)|p.Y27fs*1(2)|p.V54fs*29(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TTTGTTTTAAGGTTTTTGGAT	0.254000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			5	16					0.217242	0.21901	0.217242	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768309	31768309	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:31768309C>A	ENST00000240587.4	-	2	2717	c.2390G>T	c.(2389-2391)aGt>aTt	p.S797I		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	797					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GCCTTTGTCACTCTTCCCTTT	0.587000													46	68					1.63038e-21	2.22337e-21	0.323286	1	0
CDH10	1008	broad.mit.edu	37	5	24488112	24488112	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:24488112C>A	ENST00000264463.4	-	12	2534	c.2027G>T	c.(2026-2028)aGg>aTg	p.R676M	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	676					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TGCAGGATTCCTCAGGGTGCC	0.473000										HNSCC(23;0.051)			72	77					1.69816e-31	2.57677e-31	0.323286	1	0
PLEKHA8	84725	broad.mit.edu	37	7	30118307	30118307	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:30118307G>C	ENST00000449726.1	+	14	1814	c.1464G>C	c.(1462-1464)agG>agC	p.R488S	PLEKHA8_ENST00000258679.7_Intron|PLEKHA8_ENST00000396257.2_Intron|PLEKHA8_ENST00000396259.1_Intron	NM_001197027.1	NP_001183956.1	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8	488					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(4)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	17						GGATGCAGAGGGACCTCAGCC	0.507000													22	179					0	0	0.249174	0	0
LAMB1	3912	broad.mit.edu	37	7	107600081	107600081	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:107600081C>A	ENST00000393560.1	-	19	2675	c.2513G>T	c.(2512-2514)tGg>tTg	p.W838L	LAMB1_ENST00000393561.1_Intron|LAMB1_ENST00000222399.6_Intron			P07942	LAMB1_HUMAN	laminin, beta 1	0	Laminin EGF-like 7.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GGAACCCTGCCACAATGGCTG	0.483000													46	36					1.56989e-16	1.99998e-16	0.323286	1	0
TANC2	26115	broad.mit.edu	37	17	61497616	61497616	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:61497616A>G	ENST00000424789.2	+	25	4277	c.4273A>G	c.(4273-4275)Att>Gtt	p.I1425V	TANC2_ENST00000389520.4_Missense_Mutation_p.I1435V|RP11-269G24.3_ENST00000583552.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1425							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						AAATGTTTCCATTGGCCTCCA	0.572000													28	69					0	0	0.116897	0	0
BAI3	577	broad.mit.edu	37	6	69349325	69349325	+	Splice_Site	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:69349325G>C	ENST00000370598.1	+	3	1578		c.e3+1			NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3						negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CCCAAAGAAGGTAAGTGCCAA	0.517000													31	24					0	0	0.193644	0	0
TFEC	22797	broad.mit.edu	37	7	115580863	115580863	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:115580863G>T	ENST00000265440.7	-	8	966	c.786C>A	c.(784-786)tgC>tgA	p.C262*	TFEC_ENST00000457268.1_Nonsense_Mutation_p.C195*|TFEC_ENST00000393485.1_3'UTR|TFEC_ENST00000320239.7_Nonsense_Mutation_p.C233*	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	262						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			TCAGTTGTTGGCAATAGTCTA	0.473000													90	197					9.94044e-53	1.69431e-52	0.323286	1	0
FLG	2312	broad.mit.edu	37	1	152277200	152277200	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152277200A>G	ENST00000368799.1	-	3	10197	c.10162T>C	c.(10162-10164)Tac>Cac	p.Y3388H	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3388	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCACCTGGTAGAGGAAAGAC	0.612000									Ichthyosis				352	170					0	0	0.323286	0	0
RYR2	6262	broad.mit.edu	37	1	237777632	237777632	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:237777632G>T	ENST00000366574.2	+	37	5521	c.5204G>T	c.(5203-5205)aGc>aTc	p.S1735I	RYR2_ENST00000360064.6_Missense_Mutation_p.S1733I|RYR2_ENST00000542537.1_Missense_Mutation_p.S1719I	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1735	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAGACGAAGAGCATCACCCTG	0.537000													38	212					5.20837e-25	7.39923e-25	0.268233	1	0
PCDH11X	27328	broad.mit.edu	37	X	91090765	91090765	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:91090765G>T	ENST00000373094.1	+	1	1107	c.262G>T	c.(262-264)Ggc>Tgc	p.G88C	PCDH11X_ENST00000361724.1_Missense_Mutation_p.G88C|PCDH11X_ENST00000373097.1_Missense_Mutation_p.G88C|PCDH11X_ENST00000373088.1_Missense_Mutation_p.G88C|PCDH11X_ENST00000361655.2_Missense_Mutation_p.G88C|PCDH11X_ENST00000395337.2_Missense_Mutation_p.G88C|PCDH11X_ENST00000298274.8_Missense_Mutation_p.G88C|PCDH11X_ENST00000504220.1_Missense_Mutation_p.G88C|PCDH11X_ENST00000406881.1_Missense_Mutation_p.G88C	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	88	Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CTTCACTACTGGCGCTCGCAT	0.448000													86	116					1.6246e-59	2.84259e-59	0.323286	1	0
ABCB1	5243	broad.mit.edu	37	7	87148758	87148758	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:87148758G>A	ENST00000265724.3	-	24	3228	c.2811C>T	c.(2809-2811)atC>atT	p.I937I	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Silent_p.I873I	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	937	ABC transmembrane type-1 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TAATTCCAAAGATGTGTGCTT	0.383000													20	108					0	0	0.189662	0	0
CSMD3	114788	broad.mit.edu	37	8	113323366	113323366	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:113323366G>A	ENST00000297405.5	-	50	7970	c.7726C>T	c.(7726-7728)Cct>Tct	p.P2576S	CSMD3_ENST00000455883.2_Missense_Mutation_p.P2472S|CSMD3_ENST00000352409.3_Missense_Mutation_p.P2506S|CSMD3_ENST00000343508.3_Missense_Mutation_p.P2536S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2576	Sushi 14.					integral to membrane|plasma membrane		p.P2536A(2)|p.P2576A(2)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TATCCATGAGGTGGGGATTCT	0.403000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			92	86					0	0	0.323286	0	0
TWF1	5756	broad.mit.edu	37	12	44196110	44196110	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:44196110T>A	ENST00000395510.2	-	3	390	c.261A>T	c.(259-261)gcA>gcT	p.A87A	TWF1_ENST00000548315.1_Silent_p.A87A|TWF1_ENST00000325127.4_Silent_p.A121A|TWF1_ENST00000552521.1_5'UTR|TWF1_ENST00000547564.1_5'UTR	NM_001242397.1|NM_002822.4	NP_001229326.1|NP_002813.3	Q12792	TWF1_HUMAN	twinfilin actin-binding protein 1	87	ADF-H 1.					actin cytoskeleton|cytoplasm	actin binding|protein tyrosine kinase activity			endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|stomach(1)	14	all_cancers(12;0.00125)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.0474)		CTGGAGACCATGCAATGAATA	0.318000													34	20					0	0	0.257332	0	0
CPVL	54504	broad.mit.edu	37	7	29111968	29111968	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:29111968C>T	ENST00000409850.1	-	12	1327	c.681G>A	c.(679-681)aaG>aaA	p.K227K	CPVL_ENST00000396276.3_Silent_p.K227K|CPVL_ENST00000265394.5_Silent_p.K227K			Q9H3G5	CPVL_HUMAN	carboxypeptidase, vitellogenic-like	227					proteolysis		protein binding|serine-type carboxypeptidase activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|ovary(2)|prostate(1)|skin(1)	28						TCAGGTTGATCTTCACCTCTC	0.438000													69	214					0	0	0.323286	0	0
ZNF462	58499	broad.mit.edu	37	9	109688018	109688018	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:109688018A>T	ENST00000277225.5	+	3	2114	c.1825A>T	c.(1825-1827)Acc>Tcc	p.T609S	ZNF462_ENST00000457913.1_Missense_Mutation_p.T609S			Q96JM2	ZN462_HUMAN	zinc finger protein 462	609					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						TAATTACTCCACCACAACTCT	0.522000													452	46					0	0	0.323286	0	0
REG1A	5967	broad.mit.edu	37	2	79349996	79349996	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:79349996C>T	ENST00000233735.1	+	5	454	c.351C>T	c.(349-351)tcC>tcT	p.S117S		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	117	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GCAGTGGGTCCCTGGTCTCCT	0.567000													94	121					0	0	0.323286	0	0
GGN	199720	broad.mit.edu	37	19	38877024	38877024	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:38877024G>T	ENST00000334928.6	-	3	1010	c.878C>A	c.(877-879)cCc>cAc	p.P293H	GGN_ENST00000591809.1_Intron|AC005789.9_ENST00000585411.1_RNA	NM_152657.3	NP_689870.3	Q86UU5	GGN_HUMAN	gametogenetin	293	Interaction with GGNBP1 (By similarity).|Pro-rich.				cell differentiation|multicellular organismal development|spermatogenesis					breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGGAGGCAGGGGCCCTTGCTT	0.667000													7	13					5.16669e-11	6.0291e-11	0.080935	1	0
PTCHD4	442213	broad.mit.edu	37	6	47976478	47976478	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:47976478G>A	ENST00000543600.1	-	2	787	c.748C>T	c.(748-750)Ctg>Ttg	p.L250L	PTCHD4_ENST00000339488.4_Silent_p.L267L			Q6ZW05	CF138_HUMAN	patched domain containing 4	267	SSD.					integral to membrane	hedgehog receptor activity										AGCACCCCCAGGAGGCCCAGG	0.567000													33	90					0	0	0.153744	0	0
MRPL47	57129	broad.mit.edu	37	3	179306784	179306784	+	Splice_Site	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:179306784C>T	ENST00000476781.1	-	7	659		c.e7-1		MRPL47_ENST00000392659.2_Splice_Site|MRPL47_ENST00000259038.2_Splice_Site	NM_020409.2	NP_065142.2	Q9HD33	RM47_HUMAN	mitochondrial ribosomal protein L47						translation	mitochondrial ribosome	structural constituent of ribosome			breast(1)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|stomach(1)	11	all_cancers(143;9.62e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.18)			ACGTTCCAGTCTAGAATAAAA	0.308000													16	38					0	0	0.189662	0	0
MICAL3	57553	broad.mit.edu	37	22	18301350	18301350	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:18301350C>G	ENST00000441493.2	-	26	4429	c.4077G>C	c.(4075-4077)agG>agC	p.R1359S		NM_015241.2	NP_056056.2	Q7RTP6	MICA3_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 3	1359	Pro-rich.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		GGGACACTGGCCTGAAGGCAG	0.617000													45	2					0	0	0.323286	0	0
OR4A47	403253	broad.mit.edu	37	11	48510568	48510568	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:48510568T>G	ENST00000446524.1	+	1	300	c.224T>G	c.(223-225)aTt>aGt	p.I75S		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						TCTTCATCCATTTCCCCCAGA	0.423000													158	227					0	0	0.323286	0	0
PLCL1	5334	broad.mit.edu	37	2	198949519	198949519	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:198949519T>G	ENST00000428675.1	+	2	1676	c.1278T>G	c.(1276-1278)gcT>gcG	p.A426A	PLCL1_ENST00000437704.2_Silent_p.A328A	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	426	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GGGGGCCAGCTGACATCAATG	0.418000													16	177					0	0	0.146539	0	0
FAM83C	128876	broad.mit.edu	37	20	33875651	33875651	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:33875651A>G	ENST00000374408.3	-	4	1027	c.931T>C	c.(931-933)Tgt>Cgt	p.C311R		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	311										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			TCACCGCCACAGAAGCCCTCC	0.662000													3	3					0	0	0.184627	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72165840	72165840	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:72165840G>T	ENST00000555818.1	+	11	3865	c.3517G>T	c.(3517-3519)Gaa>Taa	p.E1173*	SIPA1L1_ENST00000358550.2_Nonsense_Mutation_p.E1173*|SIPA1L1_ENST00000537413.1_Nonsense_Mutation_p.E648*|SIPA1L1_ENST00000381232.3_Nonsense_Mutation_p.E1173*	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1173					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GTCCATGCCCGAAGGGTAGTT	0.483000													58	160					2.67592e-24	3.77727e-24	0.323286	1	0
WDR75	84128	broad.mit.edu	37	2	190340070	190340070	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:190340070A>G	ENST00000314761.4	+	21	2480	c.2420A>G	c.(2419-2421)cAg>cGg	p.Q807R		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	807						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			ATTATACATCAGTTGTCAAAA	0.368000													54	76					0	0	0.323286	0	0
PLCH1	23007	broad.mit.edu	37	3	155282834	155282834	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:155282834C>A	ENST00000460012.1	-	8	1206	c.849G>T	c.(847-849)atG>atT	p.M283I	PLCH1_ENST00000447496.2_Missense_Mutation_p.M301I|PLCH1_ENST00000414191.1_Missense_Mutation_p.M283I|PLCH1_ENST00000340059.7_Missense_Mutation_p.M301I|PLCH1_ENST00000334686.6_Missense_Mutation_p.M283I|PLCH1_ENST00000494598.1_Missense_Mutation_p.M301I			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	301					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GGGGCTGATCCATGTCTTGGT	0.463000													26	69					1.88708e-17	2.4331e-17	0.134883	1	0
HRH2	3274	broad.mit.edu	37	5	175111181	175111181	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:175111181T>G	ENST00000231683.2	+	1	2718	c.945T>G	c.(943-945)acT>acG	p.T315T	HRH2_ENST00000377291.2_Silent_p.T315T	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	315					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	CCCACAAAACTTCTCTGAGGT	0.587000													41	222					0	0	0.279185	0	0
TET1	80312	broad.mit.edu	37	10	70332191	70332191	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:70332191G>C	ENST00000373644.4	+	2	305	c.96G>C	c.(94-96)aaG>aaC	p.K32N		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	32					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						AGACAACCAAGGGAGCCAACA	0.383000													23	32					0	0	0.264190	0	0
ABCB8	11194	broad.mit.edu	37	7	150741097	150741097	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:150741097G>A	ENST00000358849.4	+	15	1898	c.1805G>A	c.(1804-1806)cGc>cAc	p.R602H	ABCB8_ENST00000297504.6_Missense_Mutation_p.R619H|ABCB8_ENST00000542328.1_Missense_Mutation_p.R514H|ABCB8_ENST00000356058.4_3'UTR|ABCB8_ENST00000498578.1_Missense_Mutation_p.R602H	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	619	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGAAGCAGCGCCTGGCCATC	0.642000													3	24					0	0	0.115264	0	0
EPAS1	2034	broad.mit.edu	37	2	46596975	46596975	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:46596975A>T	ENST00000263734.3	+	7	1299	c.789A>T	c.(787-789)gaA>gaT	p.E263D		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	263	PAS 2.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GAATCACAGAACTGATTGGTT	0.473000													10	26					0	0	0.105934	0	0
CCDC88C	440193	broad.mit.edu	37	14	91804492	91804492	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:91804492C>A	ENST00000389857.6	-	10	993	c.907G>T	c.(907-909)Gca>Tca	p.A303S		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	303					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CGGGCGTCTGCCGCTAGCTGG	0.607000													20	37					6.44725e-10	7.34897e-10	0.249174	1	0
NLRP13	126204	broad.mit.edu	37	19	56413425	56413425	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:56413425G>T	ENST00000588751.1	-	9	2789	c.2765C>A	c.(2764-2766)cCa>cAa	p.P922Q	NLRP13_ENST00000342929.3_Missense_Mutation_p.P922Q			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	922							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTTACCATCTGGGCGACCCAA	0.547000													193	21					6.51138e-99	1.18692e-98	0.323286	1	0
TMPRSS11E	28983	broad.mit.edu	37	4	69343281	69343281	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:69343281C>A	ENST00000305363.4	+	8	966	c.902C>A	c.(901-903)gCa>gAa	p.A301E		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	301	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						CTCCCTGATGCATCCTATGAG	0.408000													276	195					1.44482e-147	2.6778e-147	0.323286	1	0
TRPC6	7225	broad.mit.edu	37	11	101374793	101374793	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:101374793C>A	ENST00000344327.3	-	2	1331	c.907G>T	c.(907-909)Gaa>Taa	p.E303*	TRPC6_ENST00000360497.4_Nonsense_Mutation_p.E303*|TRPC6_ENST00000532133.1_Nonsense_Mutation_p.E303*|TRPC6_ENST00000348423.4_Nonsense_Mutation_p.E303*	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	303					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		ACTGCCAGTTCATTGCTAAGT	0.453000													79	189					4.21487e-37	6.6838e-37	0.323286	1	0
OR2F2	135948	broad.mit.edu	37	7	143633045	143633045	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:143633045G>T	ENST00000408955.2	+	1	787	c.720G>T	c.(718-720)acG>acT	p.T240T		NM_001004685.1	NP_001004685.1	O95006	OR2F2_HUMAN	olfactory receptor, family 2, subfamily F, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(19)|ovary(3)|skin(2)|stomach(1)|urinary_tract(1)	32	Melanoma(164;0.0903)					CCTTCCACACGTGTGCCTCTC	0.517000													140	116					9.55952e-61	1.67833e-60	0.323286	1	0
FCRL1	115350	broad.mit.edu	37	1	157776892	157776892	+	Splice_Site	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157776892C>T	ENST00000358292.3	-	2	103	c.52_splice	c.e2+1	p.E18_splice	FCRL1_ENST00000491942.1_Splice_Site_p.E18_splice|FCRL1_ENST00000368176.3_Splice_Site_p.E18_splice	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	18	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGCAACTCACCGGCAGGTTCA	0.483000													39	79					0	0	0.323286	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101724433	101724433	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:101724433A>T	ENST00000506729.1	-	12	2147	c.1976T>A	c.(1975-1977)aTa>aAa	p.I659K	SLCO6A1_ENST00000379810.1_Missense_Mutation_p.I406K|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.I659K|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.I597K|SLCO6A1_ENST00000513675.1_Missense_Mutation_p.I406K			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	659						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		CTTGTTATATATCCAACAACG	0.303000													20	16					0	0	0.125774	0	0
TNR	7143	broad.mit.edu	37	1	175372735	175372735	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:175372735G>A	ENST00000367674.1	-	4	1225	c.517C>T	c.(517-519)Cct>Tct	p.P173S	TNR_ENST00000263525.2_Missense_Mutation_p.P173S	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	173	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CTGCAGTGAGGGATATAGTCC	0.557000													40	113					0	0	0.312237	0	0
LRRC4	64101	broad.mit.edu	37	7	127669175	127669175	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:127669175G>C	ENST00000249363.3	-	2	1776	c.1519C>G	c.(1519-1521)Ccc>Gcc	p.P507A	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	507	Thr-rich.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		TCTGTCGCGGGTACTGCCACC	0.552000													6	28					0	0	0.080935	0	0
MEF2A	4205	broad.mit.edu	37	15	100230591	100230591	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:100230591A>T	ENST00000354410.5	+	8	1451	c.822A>T	c.(820-822)cgA>cgT	p.R274R	MEF2A_ENST00000453228.2_Silent_p.R272R|MEF2A_ENST00000558812.1_Silent_p.R204R|MEF2A_ENST00000449277.2_Silent_p.R204R|MEF2A_ENST00000557785.1_Silent_p.R272R|MEF2A_ENST00000338042.6_Silent_p.R272R|MEF2A_ENST00000557942.1_Silent_p.R272R	NM_005587.2	NP_005578.2	Q02078	MEF2A_HUMAN	myocyte enhancer factor 2A	274	Required for interaction with MAPKs.				apoptosis|BMK cascade|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|SMAD binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(1)	12	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			CAGATCTTCGAGTTGTCATCC	0.428000													53	36					0	0	0.323286	0	0
CNNM1	26507	broad.mit.edu	37	10	101136907	101136907	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:101136907A>G	ENST00000356713.4	+	7	2561	c.2272A>G	c.(2272-2274)Agc>Ggc	p.S758G	CNNM1_ENST00000370528.3_Missense_Mutation_p.S687G|CNNM1_ENST00000370534.4_Missense_Mutation_p.S414G|CNNM1_ENST00000488090.1_3'UTR|CNNM1_ENST00000446890.1_Missense_Mutation_p.S687G	NM_020348.2	NP_065081.2	Q9NRU3	CNNM1_HUMAN	cyclin M1	758					ion transport	integral to membrane|plasma membrane				NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(5)|ovary(1)|prostate(1)|skin(1)	25		Colorectal(252;0.234)		Epithelial(162;6.82e-10)|all cancers(201;5.62e-08)		CCAGCTGTACAGCAGCAGCAA	0.552000													32	6					0	0	0.214465	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36169457	36169457	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:36169457C>T	ENST00000258840.6	-	17	2708	c.2318G>A	c.(2317-2319)cGc>cAc	p.R773H	RALGAPA1_ENST00000389698.3_Intron|RALGAPA1_ENST00000382366.3_Intron|RALGAPA1_ENST00000307138.6_Intron			Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1 (catalytic)	755					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(7)|large_intestine(14)|lung(21)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TTTAGCACTGCGTATATAGGC	0.453000													5	56					0	0	0.278610	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127867	117127867	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:117127867G>T	ENST00000310357.3	-	3	1022	c.1001C>A	c.(1000-1002)tCc>tAc	p.S334Y	GPRC6A_ENST00000530250.1_Intron|GPRC6A_ENST00000368549.3_Missense_Mutation_p.S334Y	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	334					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATGGAAAGAGGATATATTCCC	0.403000													46	130					4.21674e-32	6.42679e-32	0.323286	1	0
RPL8	6132	broad.mit.edu	37	8	146017270	146017270	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:146017270C>A	ENST00000262584.3	-	3	400	c.168G>T	c.(166-168)gcG>gcT	p.A56A	RPL8_ENST00000394920.2_Silent_p.A56A|RPL8_ENST00000527914.1_Intron|RPL8_ENST00000528957.1_Silent_p.A56A|RPL8_ENST00000529163.1_Intron	NM_000973.3	NP_000964.1	P62917	RL8_HUMAN	ribosomal protein L8	56					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(12)|lung(7)|prostate(1)	20	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		TGGCGAGGGGCGCGCCGCGGC	0.677000													18	18					4.96729e-08	5.4883e-08	0.204396	1	0
USP5	8078	broad.mit.edu	37	12	6965537	6965537	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:6965537G>T	ENST00000229268.8	+	5	559	c.507G>T	c.(505-507)tgG>tgT	p.W169C	USP5_ENST00000389231.5_Missense_Mutation_p.W169C	NM_001098536.1	NP_001092006.1	P45974	UBP5_HUMAN	ubiquitin specific peptidase 5 (isopeptidase T)	169					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process	lysosome	cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(6)|endometrium(4)|kidney(2)|large_intestine(6)|lung(14)|skin(2)|urinary_tract(2)	36						TGCAGGCATGGGATGGGGAAG	0.632000													66	73					2.63401e-43	4.32302e-43	0.323286	1	0
KDM5A	5927	broad.mit.edu	37	12	404814	404814	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:404814G>A	ENST00000399788.2	-	26	4742	c.4380C>T	c.(4378-4380)gaC>gaT	p.D1460D	KDM5A_ENST00000382815.4_Silent_p.D1460D	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1460					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						GTTGAGTCTCGTCCAGAGATA	0.468000			T	NUP98	AML								201	688					0	0	0.323286	0	0
TMEM136	219902	broad.mit.edu	37	11	120198204	120198204	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:120198204G>T	ENST00000375095.2	+	2	295	c.54G>T	c.(52-54)tcG>tcT	p.S18S	TMEM136_ENST00000531346.1_Intron|TMEM136_ENST00000529187.1_Silent_p.S40S|TMEM136_ENST00000314475.2_Silent_p.S40S	NM_001198671.1|NM_001198672.1|NM_001198673.1|NM_001198674.1|NM_001198675.1	NP_001185600.1|NP_001185601.1|NP_001185602.1|NP_001185603.1|NP_001185604.1	Q6ZRR5	TM136_HUMAN	transmembrane protein 136	18						integral to membrane				endometrium(1)|lung(2)|ovary(1)	4		Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Hepatocellular(160;0.206)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.07e-06)		GCTGGCTCTCGCTCTATATTT	0.517000													71	51					9.90312e-32	1.50564e-31	0.323286	1	0
ACAN	176	broad.mit.edu	37	15	89401263	89401263	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:89401263T>A	ENST00000439576.2	+	12	5821	c.5447T>A	c.(5446-5448)gTt>gAt	p.V1816D	ACAN_ENST00000352105.7_Missense_Mutation_p.V1816D|ACAN_ENST00000559004.1_Missense_Mutation_p.V1816D|ACAN_ENST00000561243.1_Missense_Mutation_p.V1816D	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1816					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCTGACCTGGTTTCTGGTACC	0.517000													21	19					0	0	0.116897	0	0
IPO5	3843	broad.mit.edu	37	13	98658520	98658520	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:98658520C>T	ENST00000261574.5	+	17	1868	c.1688C>T	c.(1687-1689)gCg>gTg	p.A563V	IPO5_ENST00000490680.1_Missense_Mutation_p.A545V|IPO5_ENST00000539640.1_Missense_Mutation_p.A420V|IPO5_ENST00000493492.2_3'UTR	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	545					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						GTTGAGAATGCGGTTCAAAAA	0.378000													6	430					0	0	0.217242	0	0
EFCAB5	374786	broad.mit.edu	37	17	28380824	28380824	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:28380824C>A	ENST00000394835.3	+	10	2044	c.1852C>A	c.(1852-1854)Cga>Aga	p.R618R	EFCAB5_ENST00000536908.2_Silent_p.R562R|EFCAB5_ENST00000320856.5_Silent_p.R618R|EFCAB5_ENST00000394832.2_Silent_p.R618R|EFCAB5_ENST00000378738.3_Silent_p.R618R|EFCAB5_ENST00000541045.1_Silent_p.R275R	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	618							calcium ion binding	p.R618*(1)		breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						AGAACAAGATCGACACAAAGG	0.468000													7	594					0.0293803	0.0298723	0.248553	1	0
OBSCN	84033	broad.mit.edu	37	1	228565292	228565292	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:228565292C>A	ENST00000570156.2	+	113	26327	c.26253C>A	c.(26251-26253)tcC>tcA	p.S8751S	OBSCN_ENST00000366707.4_Silent_p.S5428S|OBSCN_ENST00000422127.1_Silent_p.S7794S	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7794					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ACCTGAGGTCCGAGAACATGA	0.557000													12	32					1.49906e-05	1.59102e-05	0.119110	1	0
NPAS4	266743	broad.mit.edu	37	11	66188688	66188688	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66188688G>T	ENST00000311034.2	+	1	214	c.38G>T	c.(37-39)cGg>cTg	p.R13L		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	13					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						AAGGCGCGCCGGGACCAGATC	0.697000													23	17					5.35356e-11	6.23307e-11	0.264190	1	0
RAPGEF2	9693	broad.mit.edu	37	4	160274897	160274897	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:160274897G>T	ENST00000264431.4	+	22	4286	c.3867G>T	c.(3865-3867)tgG>tgT	p.W1289C		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1289					cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		CAGGTTTATGGGCATCAAGCA	0.448000													19	77					1.96895e-08	2.18404e-08	0.264190	1	0
ECM1	1893	broad.mit.edu	37	1	150483446	150483446	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:150483446G>A	ENST00000369047.4	+	6	605	c.480G>A	c.(478-480)tgG>tgA	p.W160*	ECM1_ENST00000369049.4_Nonsense_Mutation_p.W187*|ECM1_ENST00000346569.6_Nonsense_Mutation_p.W160*|ECM1_ENST00000470432.1_3'UTR	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	160	2 X approximate repeats.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AAGGGGGCTGGGGCCACCGGC	0.607000													177	61					0	0	0.323286	0	0
CDH12	1010	broad.mit.edu	37	5	21975418	21975418	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:21975418G>T	ENST00000382254.1	-	6	1394	c.308C>A	c.(307-309)aCc>aAc	p.T103N	CDH12_ENST00000522262.1_Missense_Mutation_p.T103N|CDH12_ENST00000504376.2_Missense_Mutation_p.T103N	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	103	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TTCATCAATGGTAAAAACGGT	0.483000										HNSCC(59;0.17)			152	197					1.38108e-77	2.47094e-77	0.323286	1	0
AZGP1P1	646282	broad.mit.edu	37	7	99578429	99578429	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:99578429C>A	ENST00000425474.1	+	0	45					NR_036679.1																						GCTGTCTCTGCTGCTGCTTCT	0.582000													35	125					1.69901e-12	2.03081e-12	0.225048	1	0
SLC8A1	6546	broad.mit.edu	37	2	40657293	40657293	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:40657293C>A	ENST00000406785.1	-	2	317	c.128G>T	c.(127-129)gGa>gTa	p.G43V	SLC8A1_ENST00000542756.1_Missense_Mutation_p.G43V|SLC8A1_ENST00000542024.1_Missense_Mutation_p.G43V|SLC8A1_ENST00000408028.2_Missense_Mutation_p.G43V|SLC8A1_ENST00000406391.2_Missense_Mutation_p.G43V|SLC8A1_ENST00000405901.3_Missense_Mutation_p.G43V|SLC8A1_ENST00000405269.1_Missense_Mutation_p.G43V|SLC8A1_ENST00000403092.1_Missense_Mutation_p.G43V|SLC8A1_ENST00000402441.1_Missense_Mutation_p.G43V|SLC8A1_ENST00000332839.4_Missense_Mutation_p.G43V			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	43					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	AGTTTCATTTCCTTCTCCTTC	0.413000													71	63					2.61964e-41	4.24543e-41	0.323286	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147600746	147600746	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:147600746T>C	ENST00000361727.3	+	14	2704	c.2188T>C	c.(2188-2190)Tgc>Cgc	p.C730R		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	730	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GAAATGTGCCTGCGGCATCGA	0.552000										HNSCC(39;0.1)			20	61					0	0	0.204396	0	0
MUC3A	4584	broad.mit.edu	37	7	100552307	100552307	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100552307C>A	ENST00000319509.7	+	1	1058	c.1058C>A	c.(1057-1059)aCc>aAc	p.T353N						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TCTCCTCCCACCACCCCATTA	0.463000													40	136					5.44703e-19	7.18154e-19	0.279185	1	0
CDH12	1010	broad.mit.edu	37	5	21975282	21975282	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:21975282G>T	ENST00000382254.1	-	6	1530	c.444C>A	c.(442-444)atC>atA	p.I148I	CDH12_ENST00000522262.1_Silent_p.I148I|CDH12_ENST00000504376.2_Silent_p.I148I	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	148	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						CCTGCACTTTGATGATGAATT	0.433000										HNSCC(59;0.17)			142	147					2.79522e-57	4.84974e-57	0.323286	1	0
NTM	50863	broad.mit.edu	37	11	132016219	132016219	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:132016219C>A	ENST00000374786.1	+	2	690	c.211C>A	c.(211-213)Cgc>Agc	p.R71S	NTM_ENST00000374784.1_Missense_Mutation_p.R71S|NTM_ENST00000427481.2_Missense_Mutation_p.R62S|NTM_ENST00000539799.1_Missense_Mutation_p.R71S|NTM_ENST00000374791.3_Missense_Mutation_p.R71S|NTM_ENST00000425719.2_Missense_Mutation_p.R71S	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	71	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane		p.R71C(1)		breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						CTGGCTAAACCGCAGCACCAT	0.567000													46	109					1.57945e-13	1.92506e-13	0.301197	1	0
LCN1	3933	broad.mit.edu	37	9	138416983	138416983	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:138416983T>C	ENST00000263598.2	+	6	571	c.511T>C	c.(511-513)Tgc>Cgc	p.C171R	LCN1_ENST00000371781.3_Missense_Mutation_p.C171R	NM_001252617.1|NM_001252618.1|NM_001252619.1|NM_002297.3	NP_001239546.1|NP_001239547.1|NP_001239548.1|NP_002288.1	P31025	LCN1_HUMAN	lipocalin 1	171					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)	13		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		TGCAGAAACCTGCTCTCCAGG	0.577000													54	63					0	0	0.323286	0	0
ZIC4	84107	broad.mit.edu	37	3	147109013	147109013	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:147109013C>G	ENST00000383075.3	-	4	1221	c.709G>C	c.(709-711)Gag>Cag	p.E237Q	ZIC4_ENST00000425731.3_Missense_Mutation_p.E275Q|ZIC4_ENST00000525172.2_Missense_Mutation_p.E287Q|ZIC4_ENST00000491672.1_Missense_Mutation_p.E31Q|ZIC4_ENST00000484399.1_Missense_Mutation_p.E237Q|ZIC4_ENST00000472749.2_5'UTR|ZIC4_ENST00000473123.1_Missense_Mutation_p.E237Q	NM_032153.5	NP_115529.2	Q8N9L1	ZIC4_HUMAN	Zic family member 4	237						nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(34)|upper_aerodigestive_tract(4)	57						CCCTCGAACTCGCATCTGAAG	0.617000													44	31					0	0	0.301197	0	0
NAA16	79612	broad.mit.edu	37	13	41929322	41929322	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:41929322C>A	ENST00000379406.3	+	10	1381	c.1057C>A	c.(1057-1059)Ctt>Att	p.L353I	NAA16_ENST00000403412.3_Missense_Mutation_p.L353I|NAA16_ENST00000379367.3_Missense_Mutation_p.L353I	NM_024561.4	NP_078837.3	Q6N069	NAA16_HUMAN	N(alpha)-acetyltransferase 16, NatA auxiliary subunit	353					N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent	cytoplasm|transcription factor complex	binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|urinary_tract(2)	31						TGAAGCCTCTCTTAAAACGTG	0.259000													102	14					2.39471e-79	4.29689e-79	0.323286	1	0
OR1S1	219959	broad.mit.edu	37	11	57982334	57982334	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:57982334C>T	ENST00000309433.6	+	1	118	c.118C>T	c.(118-120)Ctc>Ttc	p.L40F		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				TCAAAACCTCCTCTTTGTGCT	0.448000													156	106					0	0	0.323286	0	0
MAML2	84441	broad.mit.edu	37	11	95825224	95825224	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:95825224T>C	ENST00000524717.1	-	2	3255	c.1971A>G	c.(1969-1971)caA>caG	p.Q657Q		NM_032427.1	NP_115803.1	Q8IZL2	MAML2_HUMAN	mastermind-like 2 (Drosophila)	657					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC3/MAML2(26)|CRTC1/MAML2(516)	breast(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	43		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				gctgctgctgttgttgctgtt	0.522000			T	"""MECT1, CRTC3"""	salivary gland mucoepidermoid								4	4					0	0	0.069234	0	0
SIRT1	23411	broad.mit.edu	37	10	69666588	69666588	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:69666588A>G	ENST00000212015.6	+	5	1037	c.984A>G	c.(982-984)aaA>aaG	p.K328K	SIRT1_ENST00000432464.1_Silent_p.K33K|SIRT1_ENST00000406900.1_Silent_p.K25K|SIRT1_ENST00000403579.1_Silent_p.K25K	NM_012238.4	NP_036370.2	Q96EB6	SIRT1_HUMAN	sirtuin 1	328	Deacetylase sirtuin-type.				apoptosis|cell aging|cellular response to hydrogen peroxide|cellular response to starvation|chromatin silencing at rDNA|DNA repair|DNA replication|establishment of chromatin silencing|histone H3 deacetylation|interspecies interaction between organisms|maintenance of chromatin silencing|muscle organ development|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of fat cell differentiation|negative regulation of helicase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine acetylation|peptidyl-lysine deacetylation|positive regulation of anti-apoptosis|positive regulation of chromatin silencing|positive regulation of DNA repair|regulation of apoptosis|regulation of cell proliferation|regulation of endodeoxyribonuclease activity|regulation of protein import into nucleus, translocation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|rRNA processing|transcription, DNA-dependent|triglyceride mobilization|white fat cell differentiation	chromatin silencing complex|cytoplasm|nuclear euchromatin|nuclear heterochromatin|nuclear inner membrane|nucleolus|PML body|rDNA heterochromatin	bHLH transcription factor binding|histone binding|HLH domain binding|identical protein binding|mitogen-activated protein kinase binding|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|p53 binding|protein C-terminus binding|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	14						TCTGTCACAAATTCATAGCCT	0.378000													34	3					0	0	0.235728	0	0
PTPRD	5789	broad.mit.edu	37	9	8499814	8499814	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:8499814C>G	ENST00000381196.4	-	22	2698	c.2155G>C	c.(2155-2157)Gag>Cag	p.E719Q	PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.E719Q|PTPRD_ENST00000360074.4_Missense_Mutation_p.E706Q|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.E719Q|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.E706Q	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	719	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCCTCTACCTCGACTTTGCGA	0.448000										TSP Lung(15;0.13)			71	192					0	0	0.323286	0	0
SLC35G5	83650	broad.mit.edu	37	8	11188962	11188962	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:11188962G>T	ENST00000382435.4	+	1	566	c.347G>T	c.(346-348)gGa>gTa	p.G116V		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	116	DUF6 1.					integral to membrane											CTCAGCATTGGATGTGCCTAC	0.597000													83	11					4.9328e-52	8.38928e-52	0.323286	1	0
PREX1	57580	broad.mit.edu	37	20	47309257	47309257	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:47309257C>G	ENST00000396220.1	-	8	1011	c.989G>C	c.(988-990)cGa>cCa	p.R330P	PREX1_ENST00000371941.3_Missense_Mutation_p.R330P			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	330	PH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			AGTGTTGATTCGACCCCTGAA	0.577000													150	169					0	0	0.323286	0	0
GABRG1	2565	broad.mit.edu	37	4	46043136	46043136	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:46043136T>C	ENST00000295452.4	-	9	1434	c.1267A>G	c.(1267-1269)Aga>Gga	p.R423G		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	423					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		GATCCTGTTCTGCAGTCTTCA	0.413000													94	69					0	0	0.323286	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53670419	53670419	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:53670419C>A	ENST00000262135.4	-	21	3217	c.3124G>T	c.(3124-3126)Gag>Tag	p.E1042*	RPGRIP1L_ENST00000379925.3_Nonsense_Mutation_p.E1076*|RPGRIP1L_ENST00000564374.1_Nonsense_Mutation_p.E1076*|RPGRIP1L_ENST00000563746.1_Nonsense_Mutation_p.E1042*|RPGRIP1L_ENST00000568009.1_5'UTR	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	1076					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				GACATGTCCTCTTCAACTGTT	0.343000													24	3					1.85244e-09	2.0938e-09	0.279207	1	0
LILRA3	11026	broad.mit.edu	37	19	54802622	54802622	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:54802622G>T	ENST00000391745.1	-	9	1186	c.870C>A	c.(868-870)ccC>ccA	p.P290P	LILRA3_ENST00000251390.3_Silent_p.P273P|LILRA3_ENST00000391744.3_Silent_p.P209P					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCCCAGCCTGGGGCTGCCGGC	0.627000													40	11					9.11151e-29	1.34309e-28	0.323286	1	0
SNX29	92017	broad.mit.edu	37	16	12497316	12497316	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:12497316C>T	ENST00000566228.1	+	18	2036	c.1967C>T	c.(1966-1968)gCg>gTg	p.A656V	SNX29_ENST00000323433.4_Missense_Mutation_p.A271V|SNX29_ENST00000306030.3_Missense_Mutation_p.A271V	NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	271					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						TCAAACCGGGCGCTGATCAAC	0.423000													7	16					0	0	0.278610	0	0
FOXA1	3169	broad.mit.edu	37	14	38064152	38064152	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:38064152C>A	ENST00000250448.2	-	1	87	c.26G>T	c.(25-27)gGg>gTg	p.G9V	FOXA1_ENST00000540786.1_Intron	NM_004496.3	NP_004487.2	P55317	FOXA1_HUMAN	forkhead box A1	9					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|prostate(12)	19	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		GGTTTCATGCCCTTCCATCTT	0.687000													17	32					0.00188189	0.0019408	0.234183	1	0
CCDC7	221016	broad.mit.edu	37	10	32806872	32806872	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:32806872G>T	ENST00000362006.5	+	11	1415		c.e11-1		CCDC7_ENST00000537047.1_Splice_Site|CCDC7_ENST00000535327.1_Splice_Site|CCDC7_ENST00000277657.6_Splice_Site|CCDC7_ENST00000539197.1_Splice_Site	NM_145023.4	NP_659460.3	Q96M83	CCDC7_HUMAN	coiled-coil domain containing 7											NS(1)|breast(2)|cervix(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(2)	14		Breast(68;0.000207)|Prostate(175;0.0107)				TTATTTTTCAGAGCTGTAAAT	0.254000													28	115					2.65835e-16	3.37829e-16	0.125774	1	0
PLCE1	51196	broad.mit.edu	37	10	96018805	96018805	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:96018805G>T	ENST00000260766.3	+	13	4346	c.3712G>T	c.(3712-3714)Gat>Tat	p.D1238Y	PLCE1_ENST00000371375.1_Missense_Mutation_p.D930Y|PLCE1_ENST00000371380.2_Missense_Mutation_p.D1238Y|PLCE1_ENST00000371385.3_Missense_Mutation_p.D930Y	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	1238					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GGATCTGTTTGATGTCTATGC	0.498000													219	24					1.89415e-129	3.49803e-129	0.323286	1	0
UNC5D	137970	broad.mit.edu	37	8	35541222	35541222	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:35541222T>C	ENST00000287272.2	+	5	748	c.728T>C	c.(727-729)cTg>cCg	p.L243P	UNC5D_ENST00000416672.1_Missense_Mutation_p.L243P|UNC5D_ENST00000453357.2_Missense_Mutation_p.L238P|UNC5D_ENST00000420357.1_Missense_Mutation_p.L243P|UNC5D_ENST00000404895.2_Missense_Mutation_p.L243P			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	299	Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		AGGAGAAGCCTGTCGGCCACT	0.512000													13	14					0	0	0.146539	0	0
KANK4	163782	broad.mit.edu	37	1	62739586	62739586	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:62739586T>A	ENST00000371153.4	-	3	1568	c.1190A>T	c.(1189-1191)cAg>cTg	p.Q397L	KANK4_ENST00000354381.3_Intron	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	397										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						TTGGTGAAACTGTCCTTCCAG	0.527000													74	169					0	0	0.323286	0	0
LARP6	55323	broad.mit.edu	37	15	71128756	71128756	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:71128756C>T	ENST00000299213.8	-	2	359	c.289G>A	c.(289-291)Gtg>Atg	p.V97M		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	97	HTH La-type RNA-binding.				RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						ATCTGATCCACCAGTTTCTTG	0.502000													48	135					0	0	0.323286	0	0
CDH2	1000	broad.mit.edu	37	18	25543473	25543473	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:25543473T>A	ENST00000269141.3	-	15	2785	c.2362A>T	c.(2362-2364)Agc>Tgc	p.S788C	CDH2_ENST00000399380.3_Missense_Mutation_p.S757C|AC015933.2_ENST00000423367.1_RNA	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	788					adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TGCAGCTGGCTCAAGTCATAG	0.488000													85	27					0	0	0.323286	0	0
KCTD3	51133	broad.mit.edu	37	1	215760009	215760009	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:215760009G>T	ENST00000259154.4	+	9	1092	c.798G>T	c.(796-798)ggG>ggT	p.G266G		NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	266						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TTCAGGATGGGGGAAGTGGAA	0.378000													96	313					6.46527e-39	1.03585e-38	0.323286	1	0
OR4C3	256144	broad.mit.edu	37	11	48347428	48347428	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:48347428T>A	ENST00000319856.4	+	1	957	c.936T>A	c.(934-936)taT>taA	p.Y312*		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						CACTCATTTATACCCTGAGAA	0.323000													111	233					0	0	0.323286	0	0
B3GALT2	8707	broad.mit.edu	37	1	193150640	193150640	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:193150640G>T	ENST00000367434.4	-	2	808	c.53C>A	c.(52-54)gCc>gAc	p.A18D	CDC73_ENST00000367435.3_Intron	NM_003783.3	NP_003774.1	O43825	B3GT2_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2	18					protein glycosylation	Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|ovary(2)	16						AGACCTTTTGGCATTCCAGGT	0.413000													25	127					1.68575e-08	1.87259e-08	0.125774	1	0
ZNF724P	440519	broad.mit.edu	37	19	23405891	23405891	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:23405891T>A	ENST00000418100.1	-	4	1273	c.1156A>T	c.(1156-1158)Aga>Tga	p.R386*																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						GTATGAATTCTCTTATGTTGA	0.388000													12	62					0	0	0.093190	0	0
OR51I2	390064	broad.mit.edu	37	11	5474877	5474877	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:5474877C>A	ENST00000341449.2	+	1	240	c.159C>A	c.(157-159)ccC>ccA	p.P53P	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGTGGAGCCCAGCCTCCATG	0.577000													136	15					1.02165e-56	1.77059e-56	0.323286	1	0
PUS7	54517	broad.mit.edu	37	7	105099703	105099703	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:105099703T>G	ENST00000356362.2	-	15	1975	c.1761A>C	c.(1759-1761)gaA>gaC	p.E587D	PUS7_ENST00000469408.1_Missense_Mutation_p.E587D	NM_019042.3	NP_061915.2	Q96PZ0	PUS7_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)	587					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|pancreas(1)|skin(1)	23						ATGCAACGACTTCCCTTCAAA	0.358000													14	50					0	0	0.146539	0	0
TRPC6	7225	broad.mit.edu	37	11	101374826	101374826	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:101374826C>A	ENST00000344327.3	-	2	1298	c.874G>T	c.(874-876)Gat>Tat	p.D292Y	TRPC6_ENST00000360497.4_Missense_Mutation_p.D292Y|TRPC6_ENST00000532133.1_Missense_Mutation_p.D292Y|TRPC6_ENST00000348423.4_Missense_Mutation_p.D292Y	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	292					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		ATGACTGGATCTTCACTAGAC	0.448000													166	142					1.70037e-88	3.07596e-88	0.323286	1	0
OR10H2	26538	broad.mit.edu	37	19	15839235	15839235	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:15839235C>G	ENST00000305899.3	+	1	402	c.382C>G	c.(382-384)Cac>Gac	p.H128D		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	128					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GGCCATCTGCCACCCCCTGCG	0.647000													41	77					0	0	0.323286	0	0
BTG4	54766	broad.mit.edu	37	11	111368797	111368797	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:111368797A>T	ENST00000525791.1	-	3	421	c.237T>A	c.(235-237)agT>agA	p.S79R	BTG4_ENST00000356018.2_Missense_Mutation_p.S79R			Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	79					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation					large_intestine(2)|upper_aerodigestive_tract(1)	3		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		AATCTACATTACTTTCCACAC	0.403000													139	89					0	0	0.323286	0	0
CTBP2	1488	broad.mit.edu	37	10	126715712	126715712	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:126715712G>A	ENST00000309035.6	-	1	747	c.617C>T	c.(616-618)cCc>cTc	p.P206L	CTBP2_ENST00000531469.1_Intron|CTBP2_ENST00000337195.5_Intron|CTBP2_ENST00000411419.2_Intron|CTBP2_ENST00000494626.2_Intron	NM_022802.2	NP_073713.2	P56545	CTBP2_HUMAN	C-terminal binding protein 2	0					negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent|viral genome replication|white fat cell differentiation	cell junction|synapse|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		all_lung(145;0.0132)|Lung NSC(174;0.0193)|all_neural(114;0.116)|Colorectal(57;0.173)		Colorectal(40;0.00572)|COAD - Colon adenocarcinoma(40;0.0127)|GBM - Glioblastoma multiforme(135;0.147)		CTGGCTGAGGGGGTAGGCAGG	0.662000													20	21					0	0	0.249174	0	0
LPA	4018	broad.mit.edu	37	6	160998291	160998291	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:160998291T>C	ENST00000447678.1	-	29	4628	c.4508A>G	c.(4507-4509)tAc>tGc	p.Y1503C	LPA_ENST00000316300.5_Missense_Mutation_p.Y1503C	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4011	Kringle 14.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATCACCATGGTAGCAATCCTG	0.448000													90	211					0	0	0.323286	0	0
ERC1	23085	broad.mit.edu	37	12	1137381	1137381	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:1137381G>T	ENST00000397203.2	+	2	718	c.312G>T	c.(310-312)atG>atT	p.M104I	ERC1_ENST00000355446.5_Missense_Mutation_p.M104I|ERC1_ENST00000543086.3_Missense_Mutation_p.M104I|ERC1_ENST00000360905.4_Missense_Mutation_p.M104I|ERC1_ENST00000546231.2_Missense_Mutation_p.M104I|ERC1_ENST00000589028.1_Missense_Mutation_p.M104I			Q8IUD2	RB6I2_HUMAN	ELKS/RAB6-interacting/CAST family member 1	104					I-kappaB phosphorylation|multicellular organismal development|positive regulation of anti-apoptosis|positive regulation of NF-kappaB transcription factor activity|protein transport	Golgi membrane|IkappaB kinase complex|presynaptic membrane	leucine zipper domain binding			NS(1)|breast(2)|cervix(2)|endometrium(2)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_epithelial(11;0.0698)|Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00239)|BRCA - Breast invasive adenocarcinoma(9;0.0567)			GTGTTCGGATGACTGCTATGG	0.498000													63	228					9.12251e-31	1.37281e-30	0.323286	1	0
HEATR1	55127	broad.mit.edu	37	1	236719125	236719125	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:236719125A>C	ENST00000366582.3	-	39	5743	c.5629T>G	c.(5629-5631)Ttc>Gtc	p.F1877V	HEATR1_ENST00000366581.2_Missense_Mutation_p.F1796V	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1877					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TGGGCTCGGAAGTCCAGGGCT	0.493000													121	398					0	0	0.323286	0	0
MMP19	4327	broad.mit.edu	37	12	56233400	56233400	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:56233400G>A	ENST00000322569.4	-	5	737	c.646C>T	c.(646-648)Cat>Tat	p.H216Y	MMP19_ENST00000409200.3_Intron|MMP19_ENST00000548629.1_Missense_Mutation_p.H193Y	NM_002429.4	NP_002420.1	Q99542	MMP19_HUMAN	matrix metallopeptidase 19	216					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						CCCAGAGCATGGCCCACTTCA	0.617000													20	49					0	0	0.279207	0	0
ARAP2	116984	broad.mit.edu	37	4	36163086	36163086	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:36163086C>A	ENST00000303965.4	-	12	2749		c.e12+1			NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2						regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						ATAGGACTCACCTCGATGAGT	0.448000													21	36					1.10513e-12	1.32402e-12	0.249174	1	0
IKZF1	10320	broad.mit.edu	37	7	50435967	50435967	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:50435967G>T	ENST00000413698.1	+	4	633	c.424G>T	c.(424-426)Gag>Tag	p.E142*	IKZF1_ENST00000357364.4_Intron|IKZF1_ENST00000331340.3_Intron|IKZF1_ENST00000438033.1_Intron|IKZF1_ENST00000346667.4_Intron|IKZF1_ENST00000343574.5_Intron|IKZF1_ENST00000439701.1_Intron|IKZF1_ENST00000492782.1_Intron|IKZF1_ENST00000440768.2_Intron|IKZF1_ENST00000349824.4_Intron|IKZF1_ENST00000359197.5_Intron			Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	0					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GGTGTCCTGGGAGCATGGCAG	0.443000			"""D,T"""	BCL6	"""ALL, DLBCL"""								17	11					6.94344e-10	7.90582e-10	0.175082	1	0
HIVEP3	59269	broad.mit.edu	37	1	42048561	42048561	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:42048561C>G	ENST00000372584.1	-	3	2922	c.1908G>C	c.(1906-1908)ttG>ttC	p.L636F	HIVEP3_ENST00000247584.5_Missense_Mutation_p.L636F|HIVEP3_ENST00000429157.2_Missense_Mutation_p.L636F|HIVEP3_ENST00000372583.1_Missense_Mutation_p.L636F	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	636	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CTTTTGTTTTCAAACCCTTCT	0.483000													50	120					0	0	0.323286	0	0
CTNND2	1501	broad.mit.edu	37	5	11236872	11236872	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:11236872G>A	ENST00000304623.8	-	10	1881	c.1692C>T	c.(1690-1692)ccC>ccT	p.P564P	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Silent_p.P227P|CTNND2_ENST00000511377.1_Silent_p.P473P|CTNND2_ENST00000359640.2_Silent_p.P564P|CTNND2_ENST00000458100.2_Silent_p.P131P	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	564					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						ACTGGACCGAGGGAAACTGGT	0.483000													68	395					0	0	0.323286	0	0
CHRM3	1131	broad.mit.edu	37	1	240070781	240070781	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:240070781G>T	ENST00000255380.4	+	5	809	c.30G>T	c.(28-30)tcG>tcT	p.S10S		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	10					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	GTACAACCTCGCCTTTGTTTC	0.483000													99	46					2.21805e-50	3.73941e-50	0.323286	1	0
KLF8	11279	broad.mit.edu	37	X	56291790	56291790	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:56291790G>T	ENST00000374928.3	+	4	745	c.259G>T	c.(259-261)Gtt>Ttt	p.V87F	KLF8_ENST00000468660.1_Missense_Mutation_p.V87F	NM_001159296.1	NP_001152768.1	O95600	KLF8_HUMAN	Kruppel-like factor 8	87					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(4)|large_intestine(6)|lung(5)|ovary(1)	16						AGTGGAACCAGTTGACCTCTC	0.537000													17	26					2.23348e-06	2.40595e-06	0.146539	1	0
COL14A1	7373	broad.mit.edu	37	8	121239508	121239508	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:121239508C>G	ENST00000297848.3	+	17	2324	c.2054C>G	c.(2053-2055)cCc>cGc	p.P685R	COL14A1_ENST00000432943.2_3'UTR|COL14A1_ENST00000309791.4_Missense_Mutation_p.P685R|COL14A1_ENST00000247781.3_Missense_Mutation_p.P590R|COL14A1_ENST00000537875.1_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	685	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGCCTGGAGCCCGGTACGGAG	0.448000													59	68					0	0	0.323286	0	0
CACNA2D1	781	broad.mit.edu	37	7	81624234	81624234	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:81624234C>A	ENST00000356860.3	-	20	2022	c.1684G>T	c.(1684-1686)Ggg>Tgg	p.G562W	CACNA2D1_ENST00000356253.5_Missense_Mutation_p.G581W	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	581						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CCACTTTCCCCATCAATCATC	0.294000													36	68					8.20599e-20	1.09307e-19	0.301197	1	0
ALPK1	80216	broad.mit.edu	37	4	113333030	113333030	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:113333030G>T	ENST00000458497.1	+	5	603	c.324G>T	c.(322-324)gcG>gcT	p.A108A	ALPK1_ENST00000505912.1_3'UTR|ALPK1_ENST00000177648.9_Silent_p.A108A|ALPK1_ENST00000504176.2_Silent_p.A30A	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	108	Poly-Ala.						ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		CGGCTGCGGCGGCTATTGTGT	0.622000													6	2					1.10513e-12	1.32402e-12	0.249174	1	0
POM121L12	285877	broad.mit.edu	37	7	53104205	53104205	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:53104205G>T	ENST00000408890.4	+	1	857	c.841G>T	c.(841-843)Gtc>Ttc	p.V281F		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	281										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CTGCAGTAGGGTCTCCTTCGC	0.622000													26	78					1.75199e-13	2.13031e-13	0.125774	1	0
OFD1	8481	broad.mit.edu	37	X	13778751	13778751	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:13778751G>T	ENST00000380567.1	+	17	2624	c.1752G>T	c.(1750-1752)agG>agT	p.R584S	OFD1_ENST00000490265.1_3'UTR|OFD1_ENST00000380550.3_Missense_Mutation_p.R684S|OFD1_ENST00000340096.6_Missense_Mutation_p.R724S			O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	724					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						CAGCCTCGAGGCTCCGCGGGG	0.542000													101	7					7.5252e-50	1.26661e-49	0.323286	1	0
FREM1	158326	broad.mit.edu	37	9	14775956	14775956	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:14775956A>C	ENST00000380881.4	-	26	5506	c.4691T>G	c.(4690-4692)cTt>cGt	p.L1564R	FREM1_ENST00000422223.2_Missense_Mutation_p.L1563R|FREM1_ENST00000380894.1_Missense_Mutation_p.L99R|FREM1_ENST00000380880.3_Missense_Mutation_p.L1563R			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1563					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		ATTGTGTTGAAGTAGCCCTGT	0.562000													59	663					0	0	0.323286	0	0
DNAH17	8632	broad.mit.edu	37	17	76475161	76475161	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:76475161C>T	ENST00000389840.5	-	51	8020	c.7896G>A	c.(7894-7896)acG>acA	p.T2632T	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.T2641T					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACTTAATGGCCGTGGGAAGAA	0.463000													5	33					0	0	0.058154	0	0
PDLIM4	8572	broad.mit.edu	37	5	131606652	131606652	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:131606652T>C	ENST00000253754.3	+	4	436	c.372T>C	c.(370-372)acT>acC	p.T124T	PDLIM4_ENST00000484620.1_3'UTR|PDLIM4_ENST00000379018.3_Silent_p.T124T|P4HA2_ENST00000471826.1_Intron	NM_001131027.1|NM_003687.3	NP_001124499.1|NP_003678.2	P50479	PDLI4_HUMAN	PDZ and LIM domain 4	124							protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|urinary_tract(1)	10			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCACCGGGACTGGGCCAGAAG	0.632000													42	183					0	0	0.301197	0	0
TRBV27	28560	broad.mit.edu	37	7	142423624	142423624	+	RNA	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142423624C>T	ENST00000506718.1	+	0	632				TRBV27_ENST00000390399.3_RNA																							GAGGAATTTCCCCCTGATCCT	0.498000													193	193					0	0	0.323286	0	0
ADH1C	126	broad.mit.edu	37	4	100260803	100260803	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:100260803G>T	ENST00000515683.1	-	0	1385					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	TGTTATTAATGCATCCAGTGA	0.318000													10	65					2.17888e-05	2.30937e-05	0.058154	1	0
ZBTB20	26137	broad.mit.edu	37	3	114069647	114069647	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:114069647T>C	ENST00000462705.1	-	11	1880	c.1059A>G	c.(1057-1059)ctA>ctG	p.L353L	ZBTB20_ENST00000481632.1_Silent_p.L353L|ZBTB20_ENST00000464560.1_Silent_p.L353L|ZBTB20_ENST00000393785.2_Silent_p.L353L|ZBTB20_ENST00000471418.1_Silent_p.L353L|ZBTB20_ENST00000357258.3_Silent_p.L353L|ZBTB20_ENST00000474710.1_Silent_p.L426L	NM_001164343.1	NP_001157815.1	Q9HC78	ZBT20_HUMAN	zinc finger and BTB domain containing 20	426					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48				LUSC - Lung squamous cell carcinoma(41;0.0581)|Lung(219;0.191)		CACCTGTTTCTAGCTGGTTTG	0.602000													31	122					0	0	0.183431	0	0
SLC4A10	57282	broad.mit.edu	37	2	162735742	162735742	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:162735742C>T	ENST00000375514.5	+	9	1280	c.993C>T	c.(991-993)gtC>gtT	p.V331V	SLC4A10_ENST00000446997.1_Silent_p.V350V|SLC4A10_ENST00000421911.1_Silent_p.V350V|SLC4A10_ENST00000415876.2_Silent_p.V320V|SLC4A10_ENST00000535165.1_Silent_p.V350V|SLC4A10_ENST00000493021.1_3'UTR|SLC4A10_ENST00000272716.5_Silent_p.V320V	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	350					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TTGCGTTTGTCAGGTTGTCTC	0.413000													32	300					0	0	0.203993	0	0
CCDC66	285331	broad.mit.edu	37	3	56627994	56627994	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:56627994C>T	ENST00000394672.3	+	10	1412	c.1342C>T	c.(1342-1344)Ctc>Ttc	p.L448F	CCDC66_ENST00000326595.7_Missense_Mutation_p.L414F|CCDC66_ENST00000436465.2_Missense_Mutation_p.L448F	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	448										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		TATGACTGCTCTCTTGGACCC	0.373000													55	152					0	0	0.323286	0	0
ETV3L	440695	broad.mit.edu	37	1	157069148	157069148	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157069148G>T	ENST00000454449.2	-	2	365	c.81C>A	c.(79-81)gcC>gcA	p.A27A		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	27						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				CGGCTTTGTAGGCCCAATCAG	0.652000													36	76					4.14481e-20	5.55932e-20	0.235728	1	0
KANK4	163782	broad.mit.edu	37	1	62728897	62728897	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:62728897G>T	ENST00000371153.4	-	7	2784	c.2406C>A	c.(2404-2406)ctC>ctA	p.L802L	KANK4_ENST00000354381.3_Silent_p.L174L|KANK4_ENST00000317477.4_5'UTR|KANK4_ENST00000371150.1_Silent_p.L158L	NM_181712.4	NP_859063.3	Q5T7N3	KANK4_HUMAN	KN motif and ankyrin repeat domains 4	802										NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(49)|ovary(3)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	81						GGACCTCGTGGAGGTAGGAGG	0.582000													10	16					9.16793e-09	1.0217e-08	0.160694	1	0
L3MBTL4	91133	broad.mit.edu	37	18	6241424	6241424	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:6241424C>A	ENST00000400104.3	-	8	685	c.485G>T	c.(484-486)tGg>tTg	p.W162L	L3MBTL4_ENST00000317931.7_Missense_Mutation_p.W162L|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.W162L|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.W162L			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	162					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding	p.W162L(1)		breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				GTAATCCATCCAAACAAATTT	0.303000													77	108					3.23364e-46	5.36399e-46	0.323286	1	0
KPNB1	3837	broad.mit.edu	37	17	45752019	45752019	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:45752019G>C	ENST00000290158.4	+	15	2190	c.1783G>C	c.(1783-1785)Gtg>Ctg	p.V595L	KPNB1_ENST00000535458.2_Missense_Mutation_p.V450L|KPNB1_ENST00000540627.1_Missense_Mutation_p.V450L|KPNB1_ENST00000537679.1_Missense_Mutation_p.V379L	NM_001276453.1|NM_002265.4	NP_001263382.1|NP_002256.2	Q14974	IMB1_HUMAN	karyopherin (importin) beta 1	595					DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|protein import into nucleus, translocation|ribosomal protein import into nucleus|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein domain specific binding|zinc ion binding			breast(1)|ovary(1)|pancreas(1)|skin(1)	4						TCTTCGGAAAGTGCAACATCA	0.408000													33	84					0	0	0.183431	0	0
CCL13	6357	broad.mit.edu	37	17	32683575	32683575	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:32683575G>T	ENST00000225844.2	+	1	105	c.30G>T	c.(28-30)ctG>ctT	p.L10L		NM_005408.2	NP_005399.1	Q99616	CCL13_HUMAN	chemokine (C-C motif) ligand 13	10					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|immune response|inflammatory response	extracellular space	chemokine activity|signal transducer activity			large_intestine(1)|prostate(1)	2		Ovarian(249;0.0443)|Breast(31;0.151)				TTCTGTGCCTGCTGCTCATGA	0.517000													98	219					4.58075e-42	7.45876e-42	0.323286	1	0
OPN4	94233	broad.mit.edu	37	10	88416013	88416013	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:88416013C>T	ENST00000372071.2	+	2	473	c.246C>T	c.(244-246)ctC>ctT	p.L82L	OPN4_ENST00000241891.5_Silent_p.L82L	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	82					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						TGGTGGGACTCACGGGGATGC	0.627000													27	31					0	0	0.153744	0	0
WDR17	116966	broad.mit.edu	37	4	177073085	177073085	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:177073085G>T	ENST00000393643.2	+	17	2679	c.2427G>T	c.(2425-2427)caG>caT	p.Q809H	WDR17_ENST00000507824.2_Missense_Mutation_p.Q816H|WDR17_ENST00000280190.4_Missense_Mutation_p.Q833H|WDR17_ENST00000508596.1_Missense_Mutation_p.Q809H	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	833										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		GACAAATTCAGAGATACTGTG	0.363000													36	21					6.19805e-25	8.78909e-25	0.225048	1	0
PFKFB1	5207	broad.mit.edu	37	X	54982667	54982667	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:54982667C>A	ENST00000375006.3	-	7	627	c.557G>T	c.(556-558)cGg>cTg	p.R186L	PFKFB1_ENST00000374992.2_Intron|PFKFB1_ENST00000545676.1_Missense_Mutation_p.R121L	NM_002625.2	NP_002616.2	P16118	F261_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	186	6-phosphofructo-2-kinase.				energy reserve metabolic process|fructose 2,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|intracellular protein kinase cascade	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 complex	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(11)|ovary(1)	24						AACCTTTTCCCGGTCACAGTC	0.478000													24	34					4.06085e-26	5.83594e-26	0.125774	1	0
ATP11B	23200	broad.mit.edu	37	3	182602614	182602614	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:182602614C>G	ENST00000323116.5	+	22	2843	c.2583C>G	c.(2581-2583)tcC>tcG	p.S861S		NM_014616.2	NP_055431.1	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	861					aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	41	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			AGTTCCTCTCCAAATTGCTTT	0.318000													16	60					0	0	0.175082	0	0
SLC9A4	389015	broad.mit.edu	37	2	103095315	103095315	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:103095315A>T	ENST00000295269.4	+	2	731	c.274A>T	c.(274-276)Agg>Tgg	p.R92W		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	92					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						CCTCTACCACAGGCTGCCAGG	0.577000													85	60					0	0	0.323286	0	0
LILRB5	10990	broad.mit.edu	37	19	54760388	54760388	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:54760388A>C	ENST00000450632.1	-	3	396	c.319T>G	c.(319-321)Tca>Gca	p.S107A	LILRB5_ENST00000345866.6_Missense_Mutation_p.S107A|LILRB5_ENST00000316219.5_Missense_Mutation_p.S107A|LILRB5_ENST00000449561.2_Missense_Mutation_p.S107A			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	107	Ig-like C2-type 1.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CTGGGCTCTGACCAGCCTGCA	0.632000													35	85					0	0	0.323286	0	0
PAK1	5058	broad.mit.edu	37	11	77070048	77070048	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:77070048C>A	ENST00000356341.3	-	6	1023	c.492G>T	c.(490-492)gtG>gtT	p.V164V	PAK1_ENST00000528203.1_Silent_p.V66V|PAK1_ENST00000278568.4_Silent_p.V164V|PAK1_ENST00000530617.1_Silent_p.V164V	NM_002576.4	NP_002567.3	Q13153	PAK1_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 1	164	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(13)|skin(2)|stomach(1)	29	all_cancers(14;1.75e-18)					GAGTCTCAGACACAGCCTTCA	0.498000													10	105					3.07112e-06	3.29908e-06	0.080935	1	0
PTGES3	10728	broad.mit.edu	37	12	57066595	57066595	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:57066595T>A	ENST00000262033.6	-	3	417		c.e3-2		PTGES3_ENST00000456859.2_Intron|PTGES3_ENST00000537473.1_Splice_Site|PTGES3_ENST00000448157.2_Splice_Site|PTGES3_ENST00000414274.3_Splice_Site|PTGES3_ENST00000436399.2_Splice_Site	NM_006601.5	NP_006592.3	Q15185	TEBP_HUMAN	prostaglandin E synthase 3 (cytosolic)						chaperone cofactor-dependent protein refolding|hormone biosynthetic process|prostaglandin biosynthetic process|signal transduction|telomere maintenance	cytosol|telomerase holoenzyme complex	prostaglandin-E synthase activity|telomerase activity|unfolded protein binding			large_intestine(1)|lung(1)	2						CCGAGACAACTGTATAAAATA	0.284000													9	18					0	0	0.069234	0	0
CSMD1	64478	broad.mit.edu	37	8	3045484	3045484	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:3045484G>T	ENST00000520002.1	-	37	6085	c.5530C>A	c.(5530-5532)Caa>Aaa	p.Q1844K	CSMD1_ENST00000542608.1_Missense_Mutation_p.Q1843K|CSMD1_ENST00000539096.1_Missense_Mutation_p.Q1843K|CSMD1_ENST00000537824.1_Missense_Mutation_p.Q1843K|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000602723.1_Missense_Mutation_p.Q1844K|CSMD1_ENST00000400186.3_Missense_Mutation_p.Q1844K|CSMD1_ENST00000602557.1_Missense_Mutation_p.Q1844K			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1844	CUB 11.			IQVISFATEQNWDSL -> DPSDQFCHGAELGLPF (in Ref. 1; AAK73475/AAG52948).		integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTGATCACTTGGATCTACCAA	0.423000													19	2					7.87624e-14	9.64139e-14	0.264190	1	0
CELSR2	1952	broad.mit.edu	37	1	109795370	109795370	+	Missense_Mutation	SNP	G	G	A	rs138048818	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:109795370G>A	ENST00000271332.3	+	1	2730	c.2669G>A	c.(2668-2670)cGg>cAg	p.R890Q		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	890	Cadherin 7.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		TATGTCTTGCGGGCATATGCA	0.562000													12	30					0	0	0.105934	0	0
GABRB3	2562	broad.mit.edu	37	15	26793083	26793083	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:26793083G>T	ENST00000541819.2	-	10	1549	c.1447C>A	c.(1447-1449)Cat>Aat	p.H483N	GABRB3_ENST00000545868.1_Missense_Mutation_p.H342N|GABRB3_ENST00000400188.3_Missense_Mutation_p.H356N|GABRB3_ENST00000299267.4_Missense_Mutation_p.H427N|GABRB3_ENST00000311550.5_Missense_Mutation_p.H427N			P28472	GBRB3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 3	427					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.H427N(2)|p.H483N(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(41)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	68		all_cancers(20;1.89e-22)|all_lung(180;6.35e-15)|Breast(32;0.000279)|Colorectal(260;0.232)		all cancers(64;1.46e-07)|Epithelial(43;2.89e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0251)|COAD - Colon adenocarcinoma(236;0.235)|Lung(196;0.243)	Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CTCCGTAGATGGGTCTTCTTG	0.488000													82	3					2.1672e-28	3.18699e-28	0.323286	1	0
OR51G1	79324	broad.mit.edu	37	11	4945559	4945559	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:4945559A>C	ENST00000321961.2	-	1	78	c.11T>G	c.(10-12)cTt>cGt	p.L4R	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCTATTAAGAAGAATTGTCAT	0.443000													32	55					0	0	0.203993	0	0
TTN	7273	broad.mit.edu	37	2	179621360	179621360	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179621360T>C	ENST00000589042.1	-	46	11067	c.10843A>G	c.(10843-10845)Agt>Ggt	p.S3615G	TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S3444G|TTN_ENST00000359218.5_Intron|TTN_ENST00000360870.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3301							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAGATACACTTTCAAAAACC	0.393000													52	112					0	0	0.323286	0	0
RIT2	6014	broad.mit.edu	37	18	40554063	40554063	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:40554063C>A	ENST00000589109.1	-	3	381	c.210G>T	c.(208-210)ttG>ttT	p.L70F	RIT2_ENST00000590910.1_Missense_Mutation_p.L70F|RIT2_ENST00000326695.5_Missense_Mutation_p.L70F|RIT2_ENST00000282028.4_Missense_Mutation_p.L70F	NM_001272077.1	NP_001259006.1	Q99578	RIT2_HUMAN	Ras-like without CAAX 2	70					nerve growth factor receptor signaling pathway|small GTPase mediated signal transduction|synaptic transmission	intracellular|plasma membrane	calmodulin binding|GTP binding|GTPase activity			endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCAAGATGTCCAAGTAAGCTG	0.378000													51	3					9.59835e-30	1.42708e-29	0.323286	1	0
PKHD1L1	93035	broad.mit.edu	37	8	110456009	110456009	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:110456009C>G	ENST00000378402.5	+	37	4773	c.4669C>G	c.(4669-4671)Cta>Gta	p.L1557V		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1557					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAAAAGATTGCTATTTGAGGT	0.408000										HNSCC(38;0.096)			40	40					0	0	0.290176	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502962	140502962	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140502962A>C	ENST00000194152.1	+	1	1382	c.1382A>C	c.(1381-1383)gAg>gCg	p.E461A		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		461	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCGTCCGCGAGAACAACAGC	0.632000													14	87					0	0	0.279207	0	0
CDC20B	166979	broad.mit.edu	37	5	54415663	54415663	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:54415663G>T	ENST00000296733.1	-	11	1599	c.1425C>A	c.(1423-1425)acC>acA	p.T475T	CDC20B_ENST00000381375.2_Silent_p.T475T|CDC20B_ENST00000322374.6_Silent_p.T433T|CDC20B_ENST00000334206.5_3'UTR	NM_001170402.1|NM_152623.2	NP_001163873.1|NP_689836.2	Q86Y33	CD20B_HUMAN	cell division cycle 20B	475										kidney(1)|large_intestine(5)|lung(7)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	19		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			CAGTGGGACAGGTCCACACAG	0.443000													362	100					1.33763e-206	2.49256e-206	0.323286	1	0
OR52N2	390077	broad.mit.edu	37	11	5841866	5841866	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:5841866G>T	ENST00000317037.2	+	1	323	c.301G>T	c.(301-303)Gcc>Tcc	p.A101S	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGCCTGCCTGGCCCAGATGTT	0.517000													258	28					3.46615e-108	6.36317e-108	0.323286	1	0
NCKAP5	344148	broad.mit.edu	37	2	133540303	133540303	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:133540303G>C	ENST00000409261.1	-	14	4454	c.4081C>G	c.(4081-4083)Cag>Gag	p.Q1361E	NCKAP5_ENST00000317721.6_Missense_Mutation_p.Q1361E|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1361							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTCCCATGCTGACTGCTGAAG	0.617000													26	89					0	0	0.279207	0	0
CLSTN2	64084	broad.mit.edu	37	3	140122633	140122633	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:140122633G>T	ENST00000458420.3	+	3	585	c.395G>T	c.(394-396)gGg>gTg	p.G132V		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	132	Cadherin 1.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						TGTGGTGCTGGGCCCCACGAG	0.587000										HNSCC(16;0.037)			234	135					6.34537e-87	1.14587e-86	0.323286	1	0
KDM5B	10765	broad.mit.edu	37	1	202718210	202718210	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:202718210A>G	ENST00000367265.3	-	14	3043	c.1879T>C	c.(1879-1881)Ttt>Ctt	p.F627L	KDM5B_ENST00000367264.2_Missense_Mutation_p.F663L	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	627					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						TCGTGGGAAAACACACAATAT	0.408000													103	39					0	0	0.323286	0	0
PSME4	23198	broad.mit.edu	37	2	54150541	54150541	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:54150541C>A	ENST00000404125.1	-	15	1880	c.1825G>T	c.(1825-1827)Gtt>Ttt	p.V609F	PSME4_ENST00000421748.2_Intron	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	609					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			AAATTAAAAACCTTCTGAAGG	0.318000													13	18					0.000219431	0.000229588	0.119110	1	0
TET1	80312	broad.mit.edu	37	10	70332192	70332192	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:70332192G>T	ENST00000373644.4	+	2	306	c.97G>T	c.(97-99)Gga>Tga	p.G33*		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	33					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						GACAACCAAGGGAGCCAACAA	0.388000													24	32					4.26978e-12	5.07036e-12	0.279207	1	0
ADCY6	112	broad.mit.edu	37	12	49166296	49166296	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:49166296C>A	ENST00000307885.4	-	16	3346	c.2652G>T	c.(2650-2652)ctG>ctT	p.L884L	ADCY6_ENST00000357869.3_Silent_p.L831L|ADCY6_ENST00000550422.1_Silent_p.L831L	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	884					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CTTACCAGTCCAGCCCATCAA	0.522000													32	55					1.71298e-08	1.90215e-08	0.193644	1	0
KRTAP8-1	337879	broad.mit.edu	37	21	32185351	32185351	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:32185351T>A	ENST00000329621.4	-	1	219	c.188A>T	c.(187-189)tAc>tTc	p.Y63F		NM_175857.3	NP_787053.1	Q8IUC2	KRA81_HUMAN	keratin associated protein 8-1	63						intermediate filament				central_nervous_system(1)|large_intestine(1)|lung(4)	6						AGCCAATCAGTAGAGAGCAAA	0.557000													82	100					0	0	0.323286	0	0
KLK5	25818	broad.mit.edu	37	19	51451939	51451939	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51451939G>T	ENST00000336334.3	-	5	1035	c.683C>A	c.(682-684)aCc>aAc	p.T228N	KLK5_ENST00000391809.2_Missense_Mutation_p.T228N|KLK5_ENST00000593428.1_Missense_Mutation_p.T228N	NM_012427.4	NP_036559.1	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5	228	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			NS(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|urinary_tract(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		GCAGAACATGGTGTCATCTAT	0.502000													16	24					1.67942e-08	1.86622e-08	0.175082	1	0
CDHR2	54825	broad.mit.edu	37	5	176016154	176016154	+	Silent	SNP	C	C	A	rs116761490	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:176016154C>A	ENST00000510636.1	+	22	3253	c.2979C>A	c.(2977-2979)tcC>tcA	p.S993S	CDHR2_ENST00000261944.5_Silent_p.S993S|CDHR2_ENST00000506348.1_Silent_p.S993S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	993	Cadherin 9.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						TCACCTCCTCCGAGGCCGACG	0.612000													95	117					4.95557e-46	8.21157e-46	0.323286	1	0
SPACA1	81833	broad.mit.edu	37	6	88775997	88775997	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:88775997C>T	ENST00000237201.1	+	7	946	c.829C>T	c.(829-831)Caa>Taa	p.Q277*	SPACA1_ENST00000462690.1_3'UTR	NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	277						integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		TTCTCTTGACCAATTACCAAC	0.403000													21	75					0	0	0.249174	0	0
ZIC1	7545	broad.mit.edu	37	3	147130340	147130340	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:147130340G>T	ENST00000282928.4	+	2	1747	c.1018G>T	c.(1018-1020)Gac>Tac	p.D340Y		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	340					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						TGAGGGCTGTGACCGGCGCTT	0.522000													52	156					2.48909e-17	3.19996e-17	0.323286	1	0
HEPH	9843	broad.mit.edu	37	X	65486408	65486408	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:65486408T>A	ENST00000519389.1	+	21	3712	c.3533T>A	c.(3532-3534)cTg>cAg	p.L1178Q	HEPH_ENST00000343002.2_Missense_Mutation_p.L1124Q|HEPH_ENST00000419594.1_Missense_Mutation_p.L935Q|HEPH_ENST00000441993.2_Missense_Mutation_p.L1126Q|HEPH_ENST00000374727.3_Missense_Mutation_p.L1127Q|HEPH_ENST00000336279.5_Missense_Mutation_p.L857Q			Q9BQS7	HEPH_HUMAN	hephaestin	1124					cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						CTCGTTGTTCTGGCTCTTGGT	0.488000													169	12					0	0	0.323286	0	0
TDRD6	221400	broad.mit.edu	37	6	46660828	46660828	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:46660828T>C	ENST00000544460.1	+	1	5217	c.4963T>C	c.(4963-4965)Tat>Cat	p.Y1655H	TDRD6_ENST00000316081.6_Missense_Mutation_p.Y1655H	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1655					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			TGACTATTTCTATGAAATAAT	0.368000													3	135					0	0	0.115264	0	0
SNAPC1	6617	broad.mit.edu	37	14	62229216	62229216	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:62229216C>T	ENST00000216294.4	+	1	142	c.38C>T	c.(37-39)gCg>gTg	p.A13V	RP11-618G20.1_ENST00000555937.1_RNA	NM_003082.3	NP_003073.1	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex, polypeptide 1, 43kDa	13	SNAPC3-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		GACTGCGAGGCGCTGCTCAGC	0.632000													60	166					0	0	0.323286	0	0
DAB2IP	153090	broad.mit.edu	37	9	124528955	124528955	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:124528955C>T	ENST00000408936.3	+	9	1825	c.1643C>T	c.(1642-1644)gCc>gTc	p.A548V	DAB2IP_ENST00000309989.1_Missense_Mutation_p.A424V|DAB2IP_ENST00000259371.2_Missense_Mutation_p.A520V			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	548	Ras-GAP.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GACCGCACTGCCCGCACCCTC	0.627000													62	59					0	0	0.323286	0	0
VEGFC	7424	broad.mit.edu	37	4	177648969	177648969	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:177648969T>A	ENST00000280193.2	-	3	930	c.515A>T	c.(514-516)cAg>cTg	p.Q172L	VEGFC_ENST00000507638.1_5'UTR	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	172					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		GTTCATGCACTGCAGCCCCTC	0.532000													85	15					0	0	0.323286	0	0
BCAR1	9564	broad.mit.edu	37	16	75263684	75263684	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:75263684C>A	ENST00000546196.1	-	7	3903	c.2251G>T	c.(2251-2253)Gcg>Tcg	p.A751S	BCAR1_ENST00000393422.2_Missense_Mutation_p.A798S|BCAR1_ENST00000418647.3_Missense_Mutation_p.A826S|BCAR1_ENST00000542031.2_Missense_Mutation_p.A778S|BCAR1_ENST00000538440.2_Missense_Mutation_p.A780S|BCAR1_ENST00000535626.2_Missense_Mutation_p.A632S|BCAR1_ENST00000420641.3_Missense_Mutation_p.A798S|BCAR1_ENST00000162330.5_Missense_Mutation_p.A780S|BCAR1_ENST00000393420.6_Missense_Mutation_p.A798S|BCAR1_ENST00000566982.1_5'UTR			P56945	BCAR1_HUMAN	breast cancer anti-estrogen resistance 1	780	Divergent helix-loop-helix motif.				actin filament organization|B cell receptor signaling pathway|blood coagulation|cell adhesion|cell division|cell migration|cell proliferation|epidermal growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|integrin-mediated signaling pathway|nerve growth factor receptor signaling pathway|platelet-derived growth factor receptor signaling pathway|positive regulation of cell migration|regulation of apoptosis|regulation of cell growth|T cell receptor signaling pathway	cytosol|focal adhesion|membrane fraction|ruffle	protein kinase binding|protein phosphatase binding|SH3 domain binding|signal transducer activity			breast(2)|central_nervous_system(5)|endometrium(1)|kidney(6)|large_intestine(1)|liver(1)|lung(13)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	35				BRCA - Breast invasive adenocarcinoma(221;0.169)		TTGCTGTGCGCCACAAAGATC	0.622000													10	28					7.03913e-09	7.85309e-09	0.093190	1	0
IL37	27178	broad.mit.edu	37	2	113676202	113676202	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:113676202G>A	ENST00000263326.3	+	5	515	c.473G>A	c.(472-474)aGg>aAg	p.R158K	IL37_ENST00000353225.3_Missense_Mutation_p.R118K|IL37_ENST00000311328.2_Missense_Mutation_p.R132K|IL37_ENST00000349806.3_Missense_Mutation_p.R97K|IL37_ENST00000352179.3_Missense_Mutation_p.R137K	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	158					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						ATCTTTTATAGGGCTCAGGTG	0.527000													37	22					0	0	0.246493	0	0
ZNF280B	140883	broad.mit.edu	37	22	22842728	22842728	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:22842728C>T	ENST00000360412.2	-	4	1771	c.996G>A	c.(994-996)gaG>gaA	p.E332E	ZNF280B_ENST00000406426.1_Silent_p.E332E	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TCCTCTGCTTCTCAAATTCCA	0.473000													195	21					0	0	0.323286	0	0
OR2T1	26696	broad.mit.edu	37	1	248570337	248570337	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248570337A>C	ENST00000366474.1	+	1	1042	c.1042A>C	c.(1042-1044)Act>Cct	p.T348P		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	348					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAAGGATGTGACTGGAGCTCT	0.507000													6	164					0	0	0.217242	0	0
NLRP14	338323	broad.mit.edu	37	11	7063863	7063863	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:7063863G>T	ENST00000299481.4	+	4	952	c.606G>T	c.(604-606)gaG>gaT	p.E202D		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	202	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ATTGGGCAGAGGGCAGTCTCT	0.453000													122	25					1.31875e-47	2.19579e-47	0.323286	1	0
SCN5A	6331	broad.mit.edu	37	3	38640459	38640459	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:38640459G>A	ENST00000413689.1	-	13	2166	c.1973C>T	c.(1972-1974)gCa>gTa	p.A658V	SCN5A_ENST00000414099.2_Missense_Mutation_p.A658V|SCN5A_ENST00000451551.2_Missense_Mutation_p.A658V|SCN5A_ENST00000333535.4_Missense_Mutation_p.A658V|SCN5A_ENST00000450102.2_Missense_Mutation_p.A658V|SCN5A_ENST00000449557.2_Missense_Mutation_p.A658V|SCN5A_ENST00000423572.2_Missense_Mutation_p.A658V|SCN5A_ENST00000443581.1_Missense_Mutation_p.A658V|SCN5A_ENST00000425664.1_Missense_Mutation_p.A658V|SCN5A_ENST00000455624.2_Missense_Mutation_p.A658V	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	658					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CCGCTGCCGTGCTCCTGGCTC	0.647000													6	111					0	0	0.058154	0	0
KIF23	9493	broad.mit.edu	37	15	69737187	69737187	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:69737187G>T	ENST00000260363.4	+	19	2555	c.2438G>T	c.(2437-2439)cGc>cTc	p.R813L	KIF23_ENST00000559279.1_Missense_Mutation_p.R709L|KIF23_ENST00000395392.2_Missense_Mutation_p.R806L|KIF23_ENST00000352331.4_Missense_Mutation_p.R709L|KIF23_ENST00000558585.1_Missense_Mutation_p.R526L|KIF23_ENST00000537891.1_Missense_Mutation_p.R526L	NM_138555.2	NP_612565.1	Q02241	KIF23_HUMAN	kinesin family member 23	813					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(7)|lung(6)|prostate(2)|skin(1)	21						AGACGATCACGCTCTGCAGGA	0.453000													39	131					2.05212e-20	2.76202e-20	0.225048	1	0
CCDC39	339829	broad.mit.edu	37	3	180366116	180366116	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:180366116C>A	ENST00000273654.4	-	16	2070	c.1451G>T	c.(1450-1452)gGt>gTt	p.G484V	CCDC39_ENST00000442201.2_Missense_Mutation_p.G400V			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	400					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			AAACAGCACACCTTTTATGAG	0.313000													98	94					8.64887e-64	1.52451e-63	0.323286	1	0
RASGRF2	5924	broad.mit.edu	37	5	80369088	80369088	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:80369088C>A	ENST00000265080.4	+	5	771	c.704C>A	c.(703-705)tCt>tAt	p.S235Y	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	235					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		TACATTTGTTCTCCTCATGCT	0.458000													35	52					9.8876e-21	1.33603e-20	0.214465	1	0
NRXN1	9378	broad.mit.edu	37	2	50573858	50573858	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:50573858C>A	ENST00000342183.5	-	1	1034	c.230G>T	c.(229-231)aGg>aTg	p.R77M	NRXN1_ENST00000402717.3_Intron|NRXN1_ENST00000404971.1_Intron|NRXN1_ENST00000406316.2_Intron|NRXN1_ENST00000405472.3_Intron|NRXN1_ENST00000401669.2_Intron|NRXN1_ENST00000331040.5_Intron|NRXN1_ENST00000406859.3_Intron|NRXN1_ENST00000401710.1_Intron	NM_138735.2	NP_620072.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	0	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGCCGGTGACCTGTAGATTGC	0.597000													15	32					1.74485e-21	2.37843e-21	0.189662	1	0
GIMAP2	26157	broad.mit.edu	37	7	150389661	150389661	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:150389661A>G	ENST00000223293.5	+	3	381	c.287A>G	c.(286-288)cAg>cGg	p.Q96R		NM_015660.2	NP_056475.1	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	96						integral to membrane	GTP binding			kidney(1)|large_intestine(1)|lung(8)|skin(2)|urinary_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		aaagaggtgcagaggtgctac	0.522000													30	71					0	0	0.125774	0	0
SPECC1	92521	broad.mit.edu	37	17	20108291	20108291	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:20108291G>T	ENST00000395530.2	+	2	894	c.686G>T	c.(685-687)cGg>cTg	p.R229L	SPECC1_ENST00000472876.1_Intron|SPECC1_ENST00000395529.3_Missense_Mutation_p.R310L|AC004702.2_ENST00000580225.1_lincRNA|SPECC1_ENST00000395525.3_Missense_Mutation_p.R229L|SPECC1_ENST00000395522.2_Missense_Mutation_p.R229L|SPECC1_ENST00000395527.4_Missense_Mutation_p.R310L|SPECC1_ENST00000261503.5_Missense_Mutation_p.R310L|SPECC1_ENST00000536879.1_Intron	NM_001033555.2	NP_001028727.1	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	310						nucleus				breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		AATGCATTACGGACATCAGGC	0.453000													104	101					1.13762e-57	1.97711e-57	0.323286	1	0
HEXIM2	124790	broad.mit.edu	37	17	43246830	43246830	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:43246830A>G	ENST00000307275.3	+	4	951	c.515A>G	c.(514-516)gAg>gGg	p.E172G	HEXIM2_ENST00000591576.1_Missense_Mutation_p.E172G|HEXIM2_ENST00000592695.1_Missense_Mutation_p.E172G|RP13-890H12.2_ENST00000589796.1_RNA	NM_144608.1	NP_653209.1	Q96MH2	HEXI2_HUMAN	hexamethylene bis-acetamide inducible 2	172					negative regulation of cyclin-dependent protein kinase activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	cyclin-dependent protein kinase inhibitor activity|protein binding|snRNA binding			endometrium(1)|large_intestine(3)|lung(1)	5						TCCAGTGGGGAGAGTGAGGCC	0.627000													8	15					0	0	0.307466	0	0
FANCG	2189	broad.mit.edu	37	9	35076537	35076537	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:35076537A>G	ENST00000378643.3	-	8	1459	c.968T>C	c.(967-969)aTt>aCt	p.I323T	FANCG_ENST00000476212.1_5'UTR	NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	323					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			TTCTACCTCAATGAGAAACTG	0.458000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					24	107					0	0	0.279207	0	0
SESTD1	91404	broad.mit.edu	37	2	180047903	180047903	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:180047903C>G	ENST00000428443.3	-	3	384	c.68G>C	c.(67-69)aGa>aCa	p.R23T	SESTD1_ENST00000486468.1_5'UTR	NM_178123.4	NP_835224.3	Q86VW0	SESD1_HUMAN	SEC14 and spectrin domains 1	23	CRAL-TRIO.				regulation of calcium ion transport via voltage-gated calcium channel activity		phosphatidic acid binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(3)	30			OV - Ovarian serous cystadenocarcinoma(117;0.0344)|Epithelial(96;0.0531)|all cancers(119;0.147)			GCCACTCCGTCTGTCTTTTCC	0.338000													30	91					0	0	0.163468	0	0
FAM170A	340069	broad.mit.edu	37	5	118970330	118970330	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:118970330C>A	ENST00000515256.1	+	3	1059	c.887C>A	c.(886-888)gCa>gAa	p.A296E				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	296	Glu-rich.					intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						aaaccagaagcaaaggaggag	0.527000													59	96					2.6711e-34	4.14449e-34	0.323286	1	0
NLRP12	91662	broad.mit.edu	37	19	54313028	54313028	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:54313028C>A	ENST00000324134.6	-	3	2053	c.1885G>T	c.(1885-1887)Gcc>Tcc	p.A629S	NLRP12_ENST00000391772.1_Missense_Mutation_p.A629S|NLRP12_ENST00000391773.1_Missense_Mutation_p.A629S|NLRP12_ENST00000535162.1_Missense_Mutation_p.A629S|NLRP12_ENST00000345770.5_Missense_Mutation_p.A629S|NLRP12_ENST00000354278.3_Missense_Mutation_p.A629S|NLRP12_ENST00000351894.4_Missense_Mutation_p.A629S|NLRP12_ENST00000391775.3_Missense_Mutation_p.A629S	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	629					negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		TGGCTCAGGGCCTGCTGGATA	0.582000													44	4					1.21353e-23	1.70291e-23	0.323286	1	0
KRTAP24-1	643803	broad.mit.edu	37	21	31654970	31654970	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:31654970G>T	ENST00000340345.4	-	1	306	c.281C>A	c.(280-282)cCc>cAc	p.P94H		NM_001085455.1	NP_001078924.1	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	94						keratin filament	structural molecule activity			breast(1)|large_intestine(3)|lung(7)|urinary_tract(3)	14						GGAGTTGCAGGGCACAGAGGA	0.567000													51	62					4.33383e-22	5.96793e-22	0.323286	1	0
MYO1D	4642	broad.mit.edu	37	17	31048086	31048086	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:31048086C>A	ENST00000318217.5	-	15	2172	c.1868G>T	c.(1867-1869)cGg>cTg	p.R623L	MYO1D_ENST00000579584.1_Missense_Mutation_p.R623L|MYO1D_ENST00000394649.4_Missense_Mutation_p.R535L	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	623	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			AAATCCTGCCCGACGCACTCT	0.473000													96	52					5.89325e-56	1.01736e-55	0.323286	1	0
PYHIN1	149628	broad.mit.edu	37	1	158913695	158913695	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158913695G>T	ENST00000368140.1	+	6	1363	c.1118G>T	c.(1117-1119)cGa>cTa	p.R373L	PYHIN1_ENST00000392254.2_Missense_Mutation_p.R373L|PYHIN1_ENST00000368138.3_Missense_Mutation_p.R364L|PYHIN1_ENST00000392252.3_Missense_Mutation_p.R364L|PYHIN1_ENST00000485134.1_3'UTR	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	373	HIN-200.				cell cycle	nuclear speck		p.R373Q(1)		breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					GATAAGCTTCGACTCTTCTGC	0.368000													66	46					2.23399e-28	3.28211e-28	0.323286	1	0
TRUB1	142940	broad.mit.edu	37	10	116735031	116735031	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:116735031T>G	ENST00000298746.3	+	8	1004	c.943T>G	c.(943-945)Ttg>Gtg	p.L315V		NM_139169.4	NP_631908.1	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase family member 1	315					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			breast(2)|kidney(2)|large_intestine(1)|lung(5)|urinary_tract(2)	12		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		CCCAGCAGAGTTGGCACTTAA	0.383000													92	100					0	0	0.323286	0	0
TPTE2	93492	broad.mit.edu	37	13	19997208	19997208	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:19997208C>A	ENST00000400230.2	-	20	1607	c.1563G>T	c.(1561-1563)gaG>gaT	p.E521D	TPTE2_ENST00000382975.4_Missense_Mutation_p.E481D|TPTE2_ENST00000457266.2_Missense_Mutation_p.E410D|TPTE2_ENST00000382978.1_Missense_Mutation_p.E481D|TPTE2_ENST00000400103.2_Missense_Mutation_p.E410D|TPTE2_ENST00000390680.2_Missense_Mutation_p.E444D|TPTE2_ENST00000382977.4_Missense_Mutation_p.E521D|TPTE2_ENST00000255310.6_Missense_Mutation_p.E444D			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	521	C2 tensin-type.			E -> K (in Ref. 1; CAD13144 and 2; AAP45146).		endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		GAAGTCATTTCTCGCCAAAAA	0.403000													64	6					7.577e-32	1.15312e-31	0.323286	1	0
CD5L	922	broad.mit.edu	37	1	157804351	157804351	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:157804351T>G	ENST00000368174.4	-	4	660	c.564A>C	c.(562-564)caA>caC	p.Q188H		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	188	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TGCAGCGTTTTTGAGTCAGTA	0.587000													11	108					0	0	0.146539	0	0
TRIM29	23650	broad.mit.edu	37	11	119986053	119986053	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:119986053G>T	ENST00000341846.5	-	8	2118	c.1697C>A	c.(1696-1698)aCt>aAt	p.T566N	TRIM29_ENST00000528870.1_Missense_Mutation_p.T99N|TRIM29_ENST00000524816.3_Missense_Mutation_p.T132N|TRIM29_ENST00000541857.1_Missense_Mutation_p.T299N|TRIM29_ENST00000529044.1_Missense_Mutation_p.T305N|TRIM29_ENST00000525887.1_5'UTR	NM_012101.3	NP_036233.2	Q14134	TRI29_HUMAN	tripartite motif containing 29	566					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		TACCAGCATAGTCTGCTTGCC	0.612000													11	20					0.00136819	0.00141243	0.093190	1	0
SOGA1	140710	broad.mit.edu	37	20	35437112	35437112	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:35437112C>A	ENST00000237536.4	-	8	2959	c.2618G>T	c.(2617-2619)cGg>cTg	p.R873L	SOGA1_ENST00000456801.2_Missense_Mutation_p.R476L|SOGA1_ENST00000357779.3_Missense_Mutation_p.R635L|SOGA1_ENST00000279034.5_Missense_Mutation_p.R635L	NM_080627.2	NP_542194.2	O94964	K0889_HUMAN	suppressor of glucose, autophagy associated 1	635										endometrium(5)|kidney(1)|lung(21)|urinary_tract(1)	28						CTCAAACTCCCGCCTCAGGAG	0.627000											OREG0025909	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	16					5.16669e-11	6.0291e-11	0.080935	1	0
OR1S2	219958	broad.mit.edu	37	11	57970791	57970791	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:57970791G>C	ENST00000302592.6	-	1	862	c.863C>G	c.(862-864)gCt>gGt	p.A288G		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	288					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				GAATAGGACAGCACCAATCTT	0.468000													106	68					0	0	0.323286	0	0
SNX14	57231	broad.mit.edu	37	6	86223583	86223583	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:86223583C>A	ENST00000314673.3	-	26	2764	c.2588G>T	c.(2587-2589)cGc>cTc	p.R863L	SNX14_ENST00000513865.1_Missense_Mutation_p.R582L|SNX14_ENST00000505648.1_Missense_Mutation_p.R811L|SNX14_ENST00000369627.2_Missense_Mutation_p.R854L|SNX14_ENST00000346348.3_Missense_Mutation_p.R810L|SNX14_ENST00000508980.1_5'UTR	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	863					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		TTGGAGAGAGCGAGGTTCAGT	0.294000													39	40					1.5731e-28	2.31554e-28	0.301197	1	0
TEX37	200523	broad.mit.edu	37	2	88828921	88828921	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:88828921T>A	ENST00000303254.3	+	4	614	c.472T>A	c.(472-474)Tgt>Agt	p.C158S		NM_152670.2	NP_689883.1			testis expressed 37																		AGGGTGTCCCTGTCTTCATTG	0.537000													61	56					0	0	0.323286	0	0
ME2	4200	broad.mit.edu	37	18	48446881	48446881	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:48446881A>G	ENST00000321341.5	+	8	1062	c.790A>G	c.(790-792)Agg>Ggg	p.R264G	ME2_ENST00000382927.3_Missense_Mutation_p.R264G	NM_002396.4	NP_002387.1	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	264					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(3)	23		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	TAATGCATTCAGGTTCTTGAG	0.328000													3	72					0	0	0.217242	0	0
RFC4	5984	broad.mit.edu	37	3	186507930	186507930	+	Splice_Site	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:186507930C>G	ENST00000392481.2	-	10	1278		c.e10+1		RFC4_ENST00000433496.1_Splice_Site|RFC4_ENST00000296273.2_Splice_Site	NM_181573.2	NP_853551.1	P35249	RFC4_HUMAN	replication factor C (activator 1) 4, 37kDa						cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TACCTACTTACGGCAAGTTTT	0.373000													58	27					0	0	0.323286	0	0
GPC5	2262	broad.mit.edu	37	13	93518665	93518665	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:93518665G>A	ENST00000377067.3	+	8	2064	c.1692G>A	c.(1690-1692)gtG>gtA	p.V564V		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	564						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGATAAGTGTGGTGATGTTAC	0.433000													253	82					0	0	0.323286	0	0
SENP3-EIF4A1	100533955	broad.mit.edu	37	17	7476069	7476069	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:7476069G>T	ENST00000579777.1	+	0	1980					NR_037926.1																						AGGCGGGGCCGGGGCGGCCAA	0.617000													10	7					9.16793e-09	1.0217e-08	0.160694	1	0
HECW2	57520	broad.mit.edu	37	2	197297907	197297907	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:197297907C>T	ENST00000260983.2	-	2	423	c.241G>A	c.(241-243)Gac>Aac	p.D81N		NM_020760.1	NP_065811.1	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	81					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(24)|lung(45)|ovary(5)|pancreas(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	113						TCTTTAATGTCCCAGAAGATA	0.498000													99	151					0	0	0.323286	0	0
SLC38A1	81539	broad.mit.edu	37	12	46622958	46622958	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:46622958T>A	ENST00000398637.5	-	5	986	c.292A>T	c.(292-294)Aac>Tac	p.N98Y	SLC38A1_ENST00000546893.1_Missense_Mutation_p.N98Y|SLC38A1_ENST00000549633.1_5'UTR|SLC38A1_ENST00000552197.1_Missense_Mutation_p.N98Y|SLC38A1_ENST00000549049.1_Missense_Mutation_p.N98Y|SLC38A1_ENST00000439706.1_Missense_Mutation_p.N98Y	NM_001077484.1|NM_001278387.1|NM_001278388.1|NM_001278389.1|NM_030674.3	NP_001070952.1|NP_001265316.1|NP_001265317.1|NP_001265318.1|NP_109599.3	Q9H2H9	S38A1_HUMAN	solute carrier family 38, member 1	98					cellular nitrogen compound metabolic process|neurotransmitter uptake	integral to membrane|plasma membrane	sodium:amino acid symporter activity			NS(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(2)	23	Lung SC(27;0.137)|Renal(347;0.236)		all cancers(1;0.00805)|OV - Ovarian serous cystadenocarcinoma(5;0.0106)|Epithelial(2;0.0344)			ATTCCAGTGTTTGCCAGGGCA	0.408000													21	55					0	0	0.264190	0	0
CPA3	1359	broad.mit.edu	37	3	148586791	148586791	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:148586791C>A	ENST00000296046.3	+	3	286	c.234C>A	c.(232-234)atC>atA	p.I78I	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	78					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CCCAAGCCATCCAGTCTGCCT	0.433000													19	81					1.42536e-11	1.67909e-11	0.309145	1	0
FBXO24	26261	broad.mit.edu	37	7	100187837	100187837	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100187837T>C	ENST00000241071.6	+	3	501	c.179T>C	c.(178-180)gTt>gCt	p.V60A	FBXO24_ENST00000498195.1_3'UTR|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000427939.2_Missense_Mutation_p.V98A|FBXO24_ENST00000360609.2_Missense_Mutation_p.V60A|FBXO24_ENST00000468962.1_Missense_Mutation_p.V48A|FBXO24_ENST00000465843.1_Missense_Mutation_p.V60A	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	60	F-box.					ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					AGAGACCTTGTTGCCCTCGGC	0.617000													43	114					0	0	0.268233	0	0
FBXW2	26190	broad.mit.edu	37	9	123550109	123550109	+	Nonsense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:123550109G>C	ENST00000373926.3	-	3	615	c.428C>G	c.(427-429)tCa>tGa	p.S143*	FBXW2_ENST00000340778.5_Nonsense_Mutation_p.S143*	NM_012164.3	NP_036296.2	Q9UKT8	FBXW2_HUMAN	F-box and WD repeat domain containing 2	143					proteolysis		protein binding|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	4						TCCAATTAATGACGAGGTTTC	0.408000													55	63					0	0	0.323286	0	0
RASA3	22821	broad.mit.edu	37	13	114839306	114839306	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:114839306G>T	ENST00000334062.7	-	2	183	c.62C>A	c.(61-63)gCc>gAc	p.A21D	RASA3_ENST00000389544.4_5'UTR|RASA3_ENST00000542651.1_Missense_Mutation_p.A21D	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	21	C2 1.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			AAGGTTTTTGGCTTCACCTAA	0.488000													21	81					0.00229938	0.00236662	0.249174	1	0
SLC27A4	10999	broad.mit.edu	37	9	131105559	131105559	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:131105559A>T	ENST00000300456.3	+	2	265	c.148A>T	c.(148-150)Agg>Tgg	p.R50W	SLC27A4_ENST00000372870.1_Splice_Site_p.Q77_splice	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	50					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding			autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						CAAGACCATCAGGCGCGATAT	0.582000													5	15					0	0	0.184627	0	0
LRCH2	57631	broad.mit.edu	37	X	114400181	114400181	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:114400181T>G	ENST00000317135.8	-	9	1266	c.1236A>C	c.(1234-1236)gaA>gaC	p.E412D	LRCH2_ENST00000538422.1_Missense_Mutation_p.E412D	NM_020871.3	NP_065922.3	Q5VUJ6	LRCH2_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 2	412										breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	19						CTGCTACATCTTCTGTGTTGG	0.323000													4	8					0	0	0.150653	0	0
MCM3	4172	broad.mit.edu	37	6	52138095	52138095	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:52138095C>G	ENST00000596288.1	-	11	1771	c.1744G>C	c.(1744-1746)Gaa>Caa	p.E582Q	MCM3_ENST00000419835.2_Missense_Mutation_p.E491Q|MCM3_ENST00000229854.7_Missense_Mutation_p.E537Q	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	537					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					TGCTGATCTTCCTGGCTAAAG	0.453000													58	79					0	0	0.323286	0	0
ZNF331	55422	broad.mit.edu	37	19	54080202	54080202	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:54080202T>G	ENST00000253144.9	+	7	1721	c.388T>G	c.(388-390)Tcc>Gcc	p.S130A	ZNF331_ENST00000513265.1_Intron|ZNF331_ENST00000512387.1_Missense_Mutation_p.S130A|ZNF331_ENST00000449416.1_Missense_Mutation_p.S130A|ZNF331_ENST00000511154.1_Missense_Mutation_p.S130A|ZNF331_ENST00000511593.2_Missense_Mutation_p.S130A|ZNF331_ENST00000513999.1_Missense_Mutation_p.S130A|ZNF331_ENST00000411977.2_Missense_Mutation_p.S130A	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		TAAGGAGAATTCCTTTGAATG	0.408000			T	?	follicular thyroid adenoma								28	75					0	0	0.134883	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77356277	77356277	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:77356277A>T	ENST00000282849.5	-	14	2537	c.2119T>A	c.(2119-2121)Tgc>Agc	p.C707S		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	707	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTTGGGGAGCAGGGAGTTCCA	0.403000													49	116					0	0	0.323286	0	0
ASTN1	460	broad.mit.edu	37	1	176983957	176983957	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:176983957C>T	ENST00000367654.2	-	8	1530	c.1517G>A	c.(1516-1518)tGc>tAc	p.C506Y	ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Missense_Mutation_p.C498Y|ASTN1_ENST00000361833.2_Missense_Mutation_p.C498Y|ASTN1_ENST00000367657.3_Missense_Mutation_p.C498Y			O14525	ASTN1_HUMAN	astrotactin 1	506	EGF-like 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GTTCCGAATGCAAAGGTGCTT	0.488000													375	983					0	0	0.323286	0	0
FRY	10129	broad.mit.edu	37	13	32811610	32811610	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:32811610A>T	ENST00000380250.3	+	44	6401	c.5905A>T	c.(5905-5907)Aac>Tac	p.N1969Y		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1969					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CACCAGCGGCAACACCGCAAC	0.542000													36	4					0	0	0.323286	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128994765	128994765	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:128994765T>A	ENST00000310343.9	-	3	249	c.250A>T	c.(250-252)Att>Ttt	p.I84F	ARHGAP32_ENST00000524655.1_Missense_Mutation_p.I10F	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	84					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TCTCCAGGAATCTCTGGAACA	0.328000													51	123					0	0	0.323286	0	0
HAPLN4	404037	broad.mit.edu	37	19	19371794	19371794	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19371794G>T	ENST00000291481.7	-	3	375	c.312C>A	c.(310-312)ccC>ccA	p.P104P	AC138430.4_ENST00000586064.2_RNA	NM_023002.2	NP_075378.1	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	104	Ig-like C2-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(1)	16			Epithelial(12;0.00575)			CCCGGTGCTGGGGGCCTAGTG	0.682000													20	51					7.92952e-12	9.38392e-12	0.294199	1	0
ACKR3	57007	broad.mit.edu	37	2	237490011	237490011	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:237490011G>T	ENST00000272928.3	+	2	1213	c.903G>T	c.(901-903)caG>caT	p.Q301H		NM_020311.2	NP_064707.1			atypical chemokine receptor 3																		ATGTCACACAGTGCCTGTCGC	0.567000													45	181					1.91693e-13	2.32996e-13	0.323286	1	0
MAST3	23031	broad.mit.edu	37	19	18254703	18254703	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:18254703G>T	ENST00000262811.5	+	21	2383	c.2383G>T	c.(2383-2385)Gat>Tat	p.D795Y		NM_015016.1	NP_055831.1	O60307	MAST3_HUMAN	microtubule associated serine/threonine kinase 3	795							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						CTCATCAGAGGATGAGGGGGT	0.632000													16	7					1.99824e-07	2.18522e-07	0.160694	1	0
C1orf222	339457	broad.mit.edu	37	1	1920039	1920039	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:1920039C>A	ENST00000434971.2	-	4	240	c.208G>T	c.(208-210)Gac>Tac	p.D70Y				Q69YW0	CA222_HUMAN	chromosome 1 open reading frame 222	0										breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|stomach(1)	11	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.82e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.75e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00435)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGCGTTCTGTCCTCAGCTGTT	0.512000													16	40					1.56452e-12	1.87078e-12	0.189662	1	0
BDP1	55814	broad.mit.edu	37	5	70797398	70797398	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:70797398G>T	ENST00000358731.4	+	14	2229	c.1966G>T	c.(1966-1968)Gaa>Taa	p.E656*	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	656					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		GAACCACGTGGAAAAAGATAA	0.323000													27	48					7.01153e-11	8.13285e-11	0.125774	1	0
PLCG2	5336	broad.mit.edu	37	16	81942046	81942046	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:81942046T>A	ENST00000359376.3	+	17	1797	c.1583T>A	c.(1582-1584)tTt>tAt	p.F528Y		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	528					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						GAACTACATTTTGGGGAGAAA	0.537000													24	58					0	0	0.294199	0	0
CORIN	10699	broad.mit.edu	37	4	47667172	47667172	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:47667172C>T	ENST00000273857.4	-	11	1465	c.1466G>A	c.(1465-1467)tGg>tAg	p.W489*	CORIN_ENST00000505909.1_Nonsense_Mutation_p.W452*|CORIN_ENST00000508498.1_Nonsense_Mutation_p.W350*|CORIN_ENST00000502252.1_Nonsense_Mutation_p.W422*|CORIN_ENST00000504584.1_Nonsense_Mutation_p.W452*	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	489	FZ 2.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						AGAAGACTCCCAGCTGATGGA	0.388000													10	97					0	0	0.058154	0	0
CEP164	22897	broad.mit.edu	37	11	117265080	117265080	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:117265080G>T	ENST00000278935.3	+	21	2778	c.2631G>T	c.(2629-2631)cgG>cgT	p.R877R	CEP164_ENST00000533706.1_3'UTR	NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	877	Glu-rich.				cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GGAAGCAGCGGGCTGAGCTTC	0.632000													9	8					1.12685e-05	1.20009e-05	0.307466	1	0
DTNA	1837	broad.mit.edu	37	18	32428261	32428261	+	Splice_Site	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:32428261A>G	ENST00000283365.9	+	13	1447	c.1094_splice	c.e13-1	p.M366_splice	DTNA_ENST00000269192.7_Splice_Site_p.M132_splice|DTNA_ENST00000599844.1_Splice_Site_p.M45_splice|DTNA_ENST00000269191.6_Splice_Site_p.M423_splice|DTNA_ENST00000597674.1_Splice_Site_p.M45_splice|DTNA_ENST00000399113.3_Splice_Site_p.M423_splice|DTNA_ENST00000269190.7_Splice_Site_p.M424_splice|DTNA_ENST00000598334.1_Splice_Site_p.M363_splice|DTNA_ENST00000595022.1_Splice_Site_p.M363_splice|DTNA_ENST00000591182.1_Splice_Site_p.M71_splice|DTNA_ENST00000598142.1_Splice_Site_p.M366_splice|DTNA_ENST00000601125.1_Splice_Site_p.M45_splice|DTNA_ENST00000598774.1_Splice_Site_p.M366_splice|DTNA_ENST00000444659.1_Splice_Site_p.M423_splice|DTNA_ENST00000597599.1_Splice_Site_p.M363_splice|DTNA_ENST00000348997.5_Splice_Site_p.M420_splice|DTNA_ENST00000556414.3_Splice_Site_p.M75_splice|DTNA_ENST00000399097.3_Splice_Site_p.M71_splice|DTNA_ENST00000596745.1_Intron|DTNA_ENST00000399121.5_Splice_Site_p.M363_splice	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	395					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						TCTTAATAGCATGCTTGAGAG	0.443000													44	27					0	0	0.323286	0	0
OR10G2	26534	broad.mit.edu	37	14	22102412	22102412	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:22102412T>C	ENST00000542433.1	-	1	684	c.587A>G	c.(586-588)gAc>gGc	p.D196G		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	196					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		GACAGTTGTGTCAGCACAGGC	0.527000													54	203					0	0	0.323286	0	0
ADH4	127	broad.mit.edu	37	4	100063887	100063887	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:100063887G>T	ENST00000508393.1	-	3	285	c.120C>A	c.(118-120)ccC>ccA	p.P40P	RP11-696N14.1_ENST00000500358.2_RNA|ADH4_ENST00000265512.7_Silent_p.P21P|ADH4_ENST00000423445.1_Silent_p.P40P|ADH4_ENST00000505590.1_Silent_p.P40P|ADH4_ENST00000504581.1_5'UTR			P08319	ADH4_HUMAN	alcohol dehydrogenase 4 (class II), pi polypeptide	21					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	CAATGCAAAGGGGCTTGCCTG	0.488000													24	19					6.00712e-18	7.79391e-18	0.163468	1	0
RGS9	8787	broad.mit.edu	37	17	63221339	63221339	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:63221339A>C	ENST00000449996.3	+	18	1690	c.1618A>C	c.(1618-1620)Agc>Cgc	p.S540R	RGS9_ENST00000262406.9_Missense_Mutation_p.S543R|RGS9_ENST00000443584.3_Missense_Mutation_p.S540R	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	543					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						AGGGGAGTGCAGCGGGTCCAT	0.692000													80	190					0	0	0.323286	0	0
MLH1	4292	broad.mit.edu	37	3	37070415	37070415	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:37070415G>A	ENST00000231790.2	+	13	1766	c.1550G>A	c.(1549-1551)gGa>gAa	p.G517E	MLH1_ENST00000455445.2_Missense_Mutation_p.G276E|MLH1_ENST00000539477.1_Missense_Mutation_p.G276E|MLH1_ENST00000458205.2_Missense_Mutation_p.G276E|MLH1_ENST00000435176.1_Missense_Mutation_p.G419E|MLH1_ENST00000536378.1_Missense_Mutation_p.G276E	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	517	Interaction with EXO1.				mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						AATGAGCAGGGACATGAGGGT	0.498000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				48	507					0	0	0.323286	0	0
CKAP2L	150468	broad.mit.edu	37	2	113514405	113514405	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:113514405T>C	ENST00000541405.1	-	4	571	c.48A>G	c.(46-48)aaA>aaG	p.K16K	CKAP2L_ENST00000481732.1_5'UTR|CKAP2L_ENST00000302450.6_Silent_p.K181K			Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	181						centrosome				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						TGTTTGTTTCTTTTAGAAAGT	0.328000													11	34					0	0	0.080935	0	0
SERPINB12	89777	broad.mit.edu	37	18	61231353	61231353	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:61231353G>T	ENST00000382768.1	+	5	705	c.705_splice	c.e5+1	p.A235_splice	SERPINB12_ENST00000269491.1_Splice_Site_p.A215_splice			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	215					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity	p.A215A(1)		kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						GTCTAAATGCGGTAGTGTATC	0.388000													55	147					2.25088e-17	2.89974e-17	0.323286	1	0
RPL11	6135	broad.mit.edu	37	1	24021209	24021209	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:24021209G>T	ENST00000374550.3	+	4	369	c.324G>T	c.(322-324)ggG>ggT	p.G108G	RPL11_ENST00000482370.1_3'UTR	NM_000975.3|NM_001199802.1	NP_000966.2|NP_001186731.1	P62913	RL11_HUMAN	ribosomal protein L11	108					endocrine pancreas development|protein localization to nucleus|protein targeting|ribosomal large subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|rRNA binding|structural constituent of ribosome			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.13e-24)|Colorectal(126;5.06e-08)|COAD - Colon adenocarcinoma(152;2.92e-06)|GBM - Glioblastoma multiforme(114;4.4e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|KIRC - Kidney renal clear cell carcinoma(1967;0.00322)|STAD - Stomach adenocarcinoma(196;0.0124)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0837)|LUSC - Lung squamous cell carcinoma(448;0.185)		TTGGTTTTGGGATCCAGGAAC	0.413000													21	86					4.35082e-09	4.87499e-09	0.219247	1	0
OR5AS1	219447	broad.mit.edu	37	11	55798329	55798329	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55798329T>C	ENST00000313555.1	+	1	435	c.435T>C	c.(433-435)atT>atC	p.I145I		NM_001001921.1	NP_001001921.1	Q8N127	O5AS1_HUMAN	olfactory receptor, family 5, subfamily AS, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(7)|large_intestine(7)|liver(1)|lung(22)|ovary(3)|prostate(4)|skin(3)|stomach(1)	48	Esophageal squamous(21;0.00693)					TCTGCTTCATTGTGTTGGCAT	0.458000													71	177					0	0	0.323286	0	0
CDH8	1006	broad.mit.edu	37	16	61687698	61687698	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:61687698G>T	ENST00000577390.1	-	12	3168	c.2214C>A	c.(2212-2214)gcC>gcA	p.A738A	CDH8_ENST00000299345.6_Intron|CDH8_ENST00000577730.1_Intron	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	738					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CATATGGCGGGGCCGTGGGAT	0.502000													44	43					4.0181e-32	6.12706e-32	0.323286	1	0
DNAJC16	23341	broad.mit.edu	37	1	15874838	15874838	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:15874838T>A	ENST00000375847.3	+	7	1102	c.938T>A	c.(937-939)aTg>aAg	p.M313K	DNAJC16_ENST00000375849.1_Missense_Mutation_p.M313K|DNAJC16_ENST00000375838.1_Missense_Mutation_p.M313K	NM_015291.2	NP_056106.1	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	313					cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ACGGAAGAGATGACAAGGCGG	0.428000													12	64					0	0	0.105934	0	0
OR5F1	338674	broad.mit.edu	37	11	55761807	55761807	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55761807G>T	ENST00000278409.1	-	1	294	c.295C>A	c.(295-297)Cta>Ata	p.L99I		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					TACATCTGTAGGAAGCAGCCA	0.468000													103	189					6.64951e-56	1.14727e-55	0.323286	1	0
CDH8	1006	broad.mit.edu	37	16	61854963	61854963	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:61854963C>A	ENST00000577390.1	-	6	1844	c.890G>T	c.(889-891)aGg>aTg	p.R297M	CDH8_ENST00000584337.1_Missense_Mutation_p.R297M|CDH8_ENST00000299345.6_Missense_Mutation_p.R297M|CDH8_ENST00000577730.1_Missense_Mutation_p.R297M	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	297	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		GGCCTTCACCCTTCCTATTGC	0.418000													47	118					3.73646e-36	5.88597e-36	0.323286	1	0
ATRNL1	26033	broad.mit.edu	37	10	116919961	116919961	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:116919961T>C	ENST00000355044.3	+	6	1116	c.990T>C	c.(988-990)ttT>ttC	p.F330F	ATRNL1_ENST00000527407.1_Silent_p.F330F|ATRNL1_ENST00000529665.1_3'UTR	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	330						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		ACAGTTCTTTTCAAATGGTCC	0.338000													36	133					0	0	0.203993	0	0
RYR2	6262	broad.mit.edu	37	1	237893643	237893643	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:237893643T>A	ENST00000366574.2	+	77	11239	c.10922T>A	c.(10921-10923)aTa>aAa	p.I3641K	RYR2_ENST00000360064.6_Missense_Mutation_p.I3639K|RYR2_ENST00000542537.1_Missense_Mutation_p.I3625K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3641					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATAAACTGATAGAAGATTTA	0.393000													21	75					0	0	0.264190	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31132262	31132262	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:31132262A>C	ENST00000304166.4	+	13	1248	c.959A>C	c.(958-960)aAc>aCc	p.N320T	ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.N320T|ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.N299T|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.N320T	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	320					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						CCTTAGGTTAACTTTGTGCTT	0.438000													7	48					0	0	0.248553	0	0
THSD7A	221981	broad.mit.edu	37	7	11676453	11676453	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:11676453T>G	ENST00000423059.3	-	2	577	c.326A>C	c.(325-327)cAg>cCg	p.Q109P	THSD7A_ENST00000480061.1_5'UTR	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	109	TSP type-1 1.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GAAACAATTCTGCTGGTTATT	0.498000										HNSCC(18;0.044)			21	205					0	0	0.234183	0	0
KIAA2018	205717	broad.mit.edu	37	3	113376755	113376755	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:113376755C>T	ENST00000316407.4	-	7	4184	c.3774G>A	c.(3772-3774)gcG>gcA	p.A1258A	KIAA2018_ENST00000478658.1_Silent_p.A1258A|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	1258					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	p.A1258A(1)		NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GGGATAAACCCGCACAGCTGG	0.483000													67	44					0	0	0.323286	0	0
ZFYVE20	64145	broad.mit.edu	37	3	15116213	15116213	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:15116213G>A	ENST00000253699.3	-	14	2044	c.1431C>T	c.(1429-1431)ggC>ggT	p.G477G	ZFYVE20_ENST00000476527.2_Silent_p.G477G	NM_022340.2	NP_071735.2	Q9H1K0	RBNS5_HUMAN	zinc finger, FYVE domain containing 20	477	Necessary for the interaction with EHD1.|Necessary for the interaction with RAB4A.				blood coagulation|endosome transport|protein transport	early endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|skin(3)|stomach(1)|urinary_tract(2)	26						CATCCATGCGGCCCGCGGCCT	0.617000													34	84					0	0	0.268233	0	0
CDH12	1010	broad.mit.edu	37	5	21751862	21751862	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:21751862G>A	ENST00000382254.1	-	15	3455	c.2369C>T	c.(2368-2370)cCt>cTt	p.P790L	CDH12_ENST00000522262.1_Missense_Mutation_p.P750L|CDH12_ENST00000504376.2_Missense_Mutation_p.P790L|RP11-804N13.1_ENST00000522350.1_RNA|CDH12_ENST00000521384.1_5'UTR	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	790					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						GACTTTATCAGGGTTATAACT	0.418000										HNSCC(59;0.17)			43	111					0	0	0.323286	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58302865	58302865	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:58302865C>G	ENST00000249750.4	-	4	1242	c.475G>C	c.(475-477)Ggg>Cgg	p.G159R	ALDH1A2_ENST00000559517.1_Missense_Mutation_p.G63R|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.G159R|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.G138R|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.G130R	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	159					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	ATGGTCATCCCATGAATTTTA	0.443000													28	36					0	0	0.153744	0	0
DOCK2	1794	broad.mit.edu	37	5	169108836	169108836	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:169108836C>T	ENST00000256935.8	+	7	639	c.559C>T	c.(559-561)Cat>Tat	p.H187Y		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	187					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GTTCCATGCACATGAGGAAGC	0.388000													45	62					0	0	0.279185	0	0
ITGAD	3681	broad.mit.edu	37	16	31435184	31435184	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:31435184T>A	ENST00000389202.2	+	27	3113	c.3064T>A	c.(3064-3066)Tgc>Agc	p.C1022S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	1022					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CATTGCTGACTGCCTGCAGTT	0.582000													12	19					0	0	0.093190	0	0
OSTM1	28962	broad.mit.edu	37	6	108372344	108372344	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:108372344C>A	ENST00000193322.3	-	4	759	c.674G>T	c.(673-675)cGt>cTt	p.R225L		NM_014028.3	NP_054747.2	Q86WC4	OSTM1_HUMAN	osteopetrosis associated transmembrane protein 1	225						integral to membrane				central_nervous_system(2)|endometrium(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)	8		all_cancers(87;3.82e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000195)|Colorectal(196;0.0293)|all_lung(197;0.0938)		BRCA - Breast invasive adenocarcinoma(108;0.0131)|Epithelial(106;0.0438)|OV - Ovarian serous cystadenocarcinoma(136;0.0571)|all cancers(137;0.0581)		GTATGCTTCACGGCAGTTTTT	0.333000													48	88					1.89013e-27	2.74952e-27	0.323286	1	0
AGBL1	123624	broad.mit.edu	37	15	86807601	86807601	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:86807601A>T	ENST00000441037.2	+	10	1156	c.1061A>T	c.(1060-1062)cAa>cTa	p.Q354L	AGBL1_ENST00000421325.2_Missense_Mutation_p.Q354L|AGBL1_ENST00000389298.3_Missense_Mutation_p.Q85L	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	354					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						AGCAAGGACCAAAGCTCCTGT	0.478000													38	67					0	0	0.268233	0	0
HTR1E	3354	broad.mit.edu	37	6	87725089	87725089	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:87725089G>T	ENST00000305344.4	+	2	740	c.37G>T	c.(37-39)Gct>Tct	p.A13S	HTR1E_ENST00000369584.1_Missense_Mutation_p.A13S	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	13					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	GGCCAGCATGGCTATAAGACC	0.468000													73	167					4.74978e-16	6.02132e-16	0.323286	1	0
SLC1A7	6512	broad.mit.edu	37	1	53580607	53580607	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:53580607G>T	ENST00000371494.4	-	3	381	c.254C>A	c.(253-255)tCt>tAt	p.S85Y	SLC1A7_ENST00000371491.4_Missense_Mutation_p.S85Y|RP11-334A14.8_ENST00000439621.1_RNA	NM_006671.4	NP_006662.3	O00341	EAA5_HUMAN	solute carrier family 1 (glutamate transporter), member 7	85						integral to membrane|plasma membrane	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Colorectal(1306;0.234)	L-Glutamic Acid(DB00142)	CAGGCGGCTAGAGGTCTTGGC	0.652000													3	8					0.004672	0.00479271	0.115264	1	0
SHROOM3	57619	broad.mit.edu	37	4	77660382	77660382	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:77660382G>C	ENST00000296043.6	+	5	2009	c.1056G>C	c.(1054-1056)cgG>cgC	p.R352R		NM_020859.3	NP_065910.3	Q8TF72	SHRM3_HUMAN	shroom family member 3	352					apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(29)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	60			Lung(101;0.0903)			ATATTCCTCGGGGCAAGGGAG	0.582000													25	14					0	0	0.294199	0	0
MROH2B	133558	broad.mit.edu	37	5	41033262	41033262	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:41033262C>A	ENST00000399564.4	-	23	2692	c.2241_splice	c.e23-1	p.D748_splice	MROH2B_ENST00000506092.2_Splice_Site_p.D303_splice	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		AGATCCATGTCCTAAAGCAAA	0.428000													19	112					2.37509e-13	2.88344e-13	0.219247	1	0
TRDN	10345	broad.mit.edu	37	6	123539850	123539850	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:123539850C>A	ENST00000334268.4	-	40	2379	c.2062G>T	c.(2062-2064)Ggg>Tgg	p.G688W	TRDN_ENST00000398178.3_Missense_Mutation_p.G696W			Q13061	TRDN_HUMAN	triadin	696					muscle contraction	integral to membrane|plasma membrane|sarcoplasmic reticulum membrane	receptor binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	41				GBM - Glioblastoma multiforme(226;0.184)		CCATTGTACCCATCCAAGTAG	0.468000													10	45					1.58986e-06	1.71921e-06	0.069234	1	0
KIF12	113220	broad.mit.edu	37	9	116854636	116854636	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:116854636G>A	ENST00000374118.3	-	15	1616	c.1379C>T	c.(1378-1380)cCg>cTg	p.P460L		NM_138424.1	NP_612433.1	Q96FN5	KIF12_HUMAN	kinesin family member 12	593					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	17						TGATGTCTTCGGGGGCCTCAC	0.607000													41	37					0	0	0.323286	0	0
SEMA5B	54437	broad.mit.edu	37	3	122632803	122632803	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:122632803C>A	ENST00000195173.4	-	15	2337	c.2034G>T	c.(2032-2034)acG>acT	p.T678T	SEMA5B_ENST00000451055.2_Silent_p.T732T|SEMA5B_ENST00000357599.3_Silent_p.T678T			Q9P283	SEM5B_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	678	TSP type-1 1.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(13)|lung(26)|ovary(2)|pancreas(3)|skin(2)|upper_aerodigestive_tract(3)	55				GBM - Glioblastoma multiforme(114;0.0367)		TGCCACAGGACGTGCTGCACA	0.677000													9	44					6.44725e-10	7.34897e-10	0.249174	1	0
OR2T34	127068	broad.mit.edu	37	1	248737450	248737450	+	Silent	SNP	G	G	A	rs148163660	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248737450G>A	ENST00000328782.2	-	1	630	c.609C>T	c.(607-609)ctC>ctT	p.L203L		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	203					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACAGGTACGTGAGCATCTTAT	0.517000													12	1788					0	0	0.217242	0	0
N4BP2	55728	broad.mit.edu	37	4	40146365	40146365	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:40146365G>C	ENST00000261435.6	+	16	5504	c.5088G>C	c.(5086-5088)ctG>ctC	p.L1696L		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1696	Smr.					cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TCCATGGGCTGCATGTGGATG	0.408000													51	53					0	0	0.323286	0	0
EPHB3	2049	broad.mit.edu	37	3	184297520	184297520	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:184297520G>A	ENST00000330394.2	+	11	2422	c.1970G>A	c.(1969-1971)cGc>cAc	p.R657H	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	657	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			CAGCCTGGCCGCCGAGAGGTG	0.607000													3	32					0	0	0.150653	0	0
PNMA2	10687	broad.mit.edu	37	8	26366261	26366261	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:26366261G>A	ENST00000522362.2	-	3	905	c.11C>T	c.(10-12)gCa>gTa	p.A4V		NM_007257.5	NP_009188.1	Q9UL42	PNMA2_HUMAN	paraneoplastic Ma antigen 2	4					apoptosis	nucleolus	protein binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)	11		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		ctctaacagtgccagcgccat	0.483000													116	20					0	0	0.323286	0	0
DMXL1	1657	broad.mit.edu	37	5	118469760	118469760	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:118469760G>T	ENST00000311085.8	+	12	2221	c.2141G>T	c.(2140-2142)gGg>gTg	p.G714V	DMXL1_ENST00000539542.1_Missense_Mutation_p.G714V	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	714										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		GACCCAGTTGGGCCATTGTCT	0.463000													55	63					2.12129e-23	2.97268e-23	0.323286	1	0
USH2A	7399	broad.mit.edu	37	1	216495271	216495271	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:216495271G>T	ENST00000366943.2	-	9	1984	c.1598C>A	c.(1597-1599)cCa>cAa	p.P533Q	USH2A_ENST00000307340.3_Missense_Mutation_p.P533Q|USH2A_ENST00000366942.3_Missense_Mutation_p.P533Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	533	Laminin EGF-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCATCTATATGGCTGGCTTGT	0.433000										HNSCC(13;0.011)			44	168					7.06795e-37	1.11852e-36	0.323286	1	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296282	39296282	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39296282G>T	ENST00000345847.4	-	1	457	c.458C>A	c.(457-459)tCt>tAt	p.S153Y		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	149	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						ttcacagcaagaggggcggca	0.662000													5	60					0.217242	0.21901	0.217242	1	0
PDYN	5173	broad.mit.edu	37	20	1961358	1961358	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:1961358G>T	ENST00000217305.2	-	4	601	c.376C>A	c.(376-378)Ctg>Atg	p.L126M	PDYN_ENST00000539905.1_Missense_Mutation_p.L126M|RP4-684O24.5_ENST00000446562.1_RNA|PDYN_ENST00000540134.1_Missense_Mutation_p.L126M	NM_001190892.1|NM_001190898.2|NM_024411.4	NP_001177821.1|NP_001177827.1|NP_077722.1	P01213	PDYN_HUMAN	prodynorphin	126					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TTCTCCTCCAGGCTCTTGCTC	0.547000													203	24					4.32429e-90	7.83176e-90	0.323286	1	0
ABCB4	5244	broad.mit.edu	37	7	87069063	87069063	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:87069063G>T	ENST00000265723.4	-	14	1762	c.1651C>A	c.(1651-1653)Ccc>Acc	p.P551T	ABCB4_ENST00000545634.1_Missense_Mutation_p.P551T|ABCB4_ENST00000453593.1_Missense_Mutation_p.P551T|ABCB4_ENST00000359206.3_Missense_Mutation_p.P551T|ABCB4_ENST00000358400.3_Missense_Mutation_p.P551T	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	551	ABC transporter 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AGGATCTTGGGGTTGCGAACC	0.537000													47	157					2.9001e-28	4.25467e-28	0.323286	1	0
DIEXF	27042	broad.mit.edu	37	1	210003483	210003483	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:210003483T>G	ENST00000491415.2	+	2	195	c.138T>G	c.(136-138)atT>atG	p.I46M		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	46					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						AGCCACAGATTTGTCAACTGG	0.323000													7	42					0	0	0.307466	0	0
OR5J2	282775	broad.mit.edu	37	11	55944611	55944611	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55944611C>A	ENST00000312298.1	+	1	518	c.518C>A	c.(517-519)gCt>gAt	p.A173D		NM_001005492.1	NP_001005492.1	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J, member 2	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A173G(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	44	Esophageal squamous(21;0.00693)					AGGCTAAATGCTGTCAGCCAC	0.438000													32	87					1.88708e-17	2.4331e-17	0.134883	1	0
CPS1	1373	broad.mit.edu	37	2	211465309	211465309	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:211465309A>C	ENST00000233072.5	+	15	1776	c.1580A>C	c.(1579-1581)aAg>aCg	p.K527T	CPS1_ENST00000451903.2_Missense_Mutation_p.K76T|CPS1_ENST00000430249.2_Missense_Mutation_p.K533T	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	527					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GGTGTGCTCAAGGAATATGGT	0.363000													15	203					0	0	0.146539	0	0
CCDC67	159989	broad.mit.edu	37	11	93088627	93088627	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:93088627G>A	ENST00000298050.3	+	3	220	c.120G>A	c.(118-120)atG>atA	p.M40I	CCDC67_ENST00000527307.1_Missense_Mutation_p.M40I|CCDC67_ENST00000530053.1_3'UTR	NM_181645.3	NP_857596.2	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	40										endometrium(3)|kidney(1)|large_intestine(1)|lung(10)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				AAAGAAAGATGCGGGCTTTGG	0.403000													97	69					0	0	0.323286	0	0
ABCA6	23460	broad.mit.edu	37	17	67098978	67098978	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:67098978T>A	ENST00000284425.2	-	21	3046	c.2872A>T	c.(2872-2874)Aag>Tag	p.K958*		NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	958					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AAACATACCTTTTGTTTACCA	0.313000													17	35					0	0	0.160694	0	0
NEDD4	4734	broad.mit.edu	37	15	56207664	56207664	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:56207664T>G	ENST00000508342.1	-	1	1665	c.1366A>C	c.(1366-1368)Agt>Cgt	p.S456R	NEDD4_ENST00000435532.3_Intron|NEDD4_ENST00000506154.1_Missense_Mutation_p.S456R|NEDD4_ENST00000338963.2_Missense_Mutation_p.S456R			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	456					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		AATGAAATACTTCTTCGTAAA	0.368000													20	74					0	0	0.204396	0	0
CYTH4	27128	broad.mit.edu	37	22	37695347	37695347	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:37695347G>T	ENST00000248901.6	+	6	621	c.434_splice	c.e6+1	p.R145_splice	CYTH4_ENST00000402997.1_Splice_Site_p.R145_splice|CYTH4_ENST00000439667.1_3'UTR|CYTH4_ENST00000405206.3_Splice_Site_p.R145_splice	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	145	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CAGGCCCTCAGGTGAGTAGTC	0.642000													44	2					5.82089e-37	9.21641e-37	0.323286	1	0
ABLIM1	3983	broad.mit.edu	37	10	116203838	116203838	+	Missense_Mutation	SNP	C	C	A	rs143955890	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:116203838C>A	ENST00000533213.2	-	17	2004	c.1703G>T	c.(1702-1704)cGg>cTg	p.R568L	ABLIM1_ENST00000277895.5_Missense_Mutation_p.R628L|ABLIM1_ENST00000369266.3_Missense_Mutation_p.R305L|ABLIM1_ENST00000392952.3_Missense_Mutation_p.R305L|ABLIM1_ENST00000369253.2_Missense_Mutation_p.R251L|ABLIM1_ENST00000369252.4_Missense_Mutation_p.R568L			O14639	ABLM1_HUMAN	actin binding LIM protein 1	628					axon guidance|cytoskeleton organization|organ morphogenesis|visual perception	actin cytoskeleton|cytoplasm	actin binding|zinc ion binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	30		Colorectal(252;0.0373)|Breast(234;0.231)		Epithelial(162;0.0132)|all cancers(201;0.0383)		TGACCTTTCCCGGCTCTCTTT	0.458000													82	108					6.83469e-46	1.13193e-45	0.323286	1	0
TRAK1	22906	broad.mit.edu	37	3	42242491	42242491	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:42242491G>A	ENST00000327628.5	+	12	1772	c.1372G>A	c.(1372-1374)Gtc>Atc	p.V458I	TRAK1_ENST00000487159.1_3'UTR|TRAK1_ENST00000449246.1_Missense_Mutation_p.V384I|TRAK1_ENST00000341421.3_Missense_Mutation_p.V400I|TRAK1_ENST00000396175.1_Missense_Mutation_p.V400I	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	458	Interaction with HGS.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						AGGCAACGTCGTCCTCGACAA	0.592000													52	82					0	0	0.323286	0	0
OR4A15	81328	broad.mit.edu	37	11	55136271	55136271	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55136271T>G	ENST00000314706.3	+	1	912	c.912T>G	c.(910-912)acT>acG	p.T304T		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						TAGTTCTAACTTTTATAACTC	0.383000													118	248					0	0	0.323286	0	0
ZNF582	147948	broad.mit.edu	37	19	56895530	56895530	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:56895530C>A	ENST00000301310.4	-	5	1414	c.1256G>T	c.(1255-1257)gGt>gTt	p.G419V	ZNF582_ENST00000586929.1_Missense_Mutation_p.G419V	NM_144690.1	NP_653291.1	Q96NG8	ZN582_HUMAN	zinc finger protein 582	419					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		TGGCTTTTCACCTGTATGAAT	0.403000													72	53					2.0493e-37	3.25304e-37	0.323286	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75929681	75929681	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:75929681A>G	ENST00000262207.4	+	10	1591	c.1123A>G	c.(1123-1125)Att>Gtt	p.I375V	CRISPLD1_ENST00000517786.1_Missense_Mutation_p.I189V|CRISPLD1_ENST00000523524.1_Missense_Mutation_p.I187V	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	375	LCCL 1.					extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			TATTCAAACAATTGGGTAAGT	0.303000													55	64					0	0	0.323286	0	0
AHNAK	79026	broad.mit.edu	37	11	62289878	62289878	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:62289878G>A	ENST00000378024.4	-	5	12285	c.12011C>T	c.(12010-12012)cCt>cTt	p.P4004L	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4004					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ATCAAAGTCAGGCATGGAGAT	0.458000													102	260					0	0	0.323286	0	0
F5	2153	broad.mit.edu	37	1	169489849	169489849	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:169489849T>A	ENST00000367796.3	-	22	6318	c.6117A>T	c.(6115-6117)ccA>ccT	p.P2039P	F5_ENST00000367797.3_Silent_p.P2034P			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	2034	F5/8 type C 1.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCACAATAGGTGGGTCAAACT	0.373000													16	44					0	0	0.125774	0	0
SRGAP1	57522	broad.mit.edu	37	12	64536284	64536284	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:64536284C>T	ENST00000355086.3	+	22	3614	c.3090C>T	c.(3088-3090)tcC>tcT	p.S1030S	SRGAP1_ENST00000543397.1_Silent_p.S967S|SRGAP1_ENST00000357825.3_Silent_p.S1007S	NM_020762.2	NP_065813.1	Q7Z6B7	SRGP1_HUMAN	SLIT-ROBO Rho GTPase activating protein 1	1030	Poly-Ser.				axon guidance	cytosol				breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	65			GBM - Glioblastoma multiforme(3;0.000139)|BRCA - Breast invasive adenocarcinoma(9;0.225)	GBM - Glioblastoma multiforme(28;0.0608)		GCACGAGCTCCTCCAGTGACA	0.557000													24	149					0	0	0.309145	0	0
RYBP	23429	broad.mit.edu	37	3	72427727	72427727	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:72427727C>A	ENST00000477973.1	-	4	760	c.761G>T	c.(760-762)cGt>cTt	p.R254L		NM_012234.5	NP_036366.3	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	0					apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			prostate(1)|upper_aerodigestive_tract(1)	2		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		ATGACGGTGACGTTGCCCACA	0.522000													72	138					6.30617e-38	1.00412e-37	0.323286	1	0
LRRC7	57554	broad.mit.edu	37	1	70257779	70257779	+	Silent	SNP	T	T	C	rs34658389	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:70257779T>C	ENST00000310961.5	+	5	676	c.258T>C	c.(256-258)ctT>ctC	p.L86L	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000370958.1_Silent_p.L119L|LRRC7_ENST00000035383.5_Silent_p.L81L			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	81						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						ATAACGACCTTTCAAATCTGC	0.299000													23	173					0	0	0.294199	0	0
TECTA	7007	broad.mit.edu	37	11	121000422	121000422	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:121000422A>G	ENST00000392793.1	+	10	2714	c.2443A>G	c.(2443-2445)Acg>Gcg	p.T815A	TECTA_ENST00000264037.2_Missense_Mutation_p.T815A			O75443	TECTA_HUMAN	tectorin alpha	815	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CAAAAACAGTACGACAGTGGA	0.448000													68	185					0	0	0.323286	0	0
LINC01239	441389	broad.mit.edu	37	9	22823301	22823301	+	RNA	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:22823301G>A	ENST00000436786.1	+	0	1436					NR_038977.1																						ttctccaaatggagccccaga	0.468000													9	57					0	0	0.307466	0	0
NDST4	64579	broad.mit.edu	37	4	115767154	115767154	+	Splice_Site	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:115767154C>G	ENST00000264363.2	-	10	2619		c.e10-1			NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4							Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		GTCCATATACCTGAAGGCAGA	0.328000													27	6					0	0	0.294199	0	0
ABL1	25	broad.mit.edu	37	9	133738224	133738224	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:133738224G>T	ENST00000318560.5	+	4	1005	c.624G>T	c.(622-624)ggG>ggT	p.G208G		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	208	SH2.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	TGGCCGACGGGCTCATCACCA	0.567000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								35	56					1.15505e-17	1.49298e-17	0.279185	1	0
TTN	7273	broad.mit.edu	37	2	179640518	179640518	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179640518C>T	ENST00000589042.1	-	28	6297	c.6073G>A	c.(6073-6075)Gaa>Aaa	p.E2025K	TTN_ENST00000342175.6_Missense_Mutation_p.E1979K|TTN_ENST00000359218.5_Missense_Mutation_p.E1979K|TTN_ENST00000360870.5_Missense_Mutation_p.E2025K|TTN_ENST00000591111.1_Missense_Mutation_p.E2025K|TTN_ENST00000460472.2_Missense_Mutation_p.E1979K|TTN_ENST00000342992.6_Missense_Mutation_p.E2025K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1787							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCATAGGATTCATCCTTCTTT	0.458000													24	300					0	0	0.279207	0	0
CAPN2	824	broad.mit.edu	37	1	223943328	223943328	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:223943328A>G	ENST00000295006.5	+	10	1591	c.1282A>G	c.(1282-1284)Acc>Gcc	p.T428A	CAPN2_ENST00000433674.2_Missense_Mutation_p.T350A	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	428	Domain III.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		GGACATGCACACCATCGGCTT	0.622000													9	36					0	0	0.307466	0	0
PLA2R1	22925	broad.mit.edu	37	2	160806217	160806217	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:160806217G>A	ENST00000283243.7	-	25	3817	c.3611C>T	c.(3610-3612)tCc>tTc	p.S1204F	PLA2R1_ENST00000392771.1_Missense_Mutation_p.S1204F	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	1204	C-type lectin 7.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						ACCAAGGAGGGAGGACTCCTC	0.488000													79	71					0	0	0.323286	0	0
ZNF724P	440519	broad.mit.edu	37	19	23406355	23406355	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:23406355C>G	ENST00000418100.1	-	4	809	c.692G>C	c.(691-693)tGt>tCt	p.C231S																	endometrium(3)|kidney(1)|lung(2)|ovary(2)	8						GGCTATGCCACATTCTTCACA	0.368000													4	18					0	0	0.150653	0	0
SLC2A7	155184	broad.mit.edu	37	1	9085118	9085118	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:9085118G>C	ENST00000400906.1	-	2	66	c.67C>G	c.(67-69)Ctg>Gtg	p.L23V		NM_207420.2	NP_997303.2	Q6PXP3	GTR7_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 7	23						integral to membrane|plasma membrane	sugar transmembrane transporter activity			NS(1)|breast(1)|endometrium(4)|large_intestine(10)|lung(4)|prostate(2)|skin(2)	24	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.04e-07)|COAD - Colon adenocarcinoma(227;7.66e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GCCAGCAACAGCGTCGGCTGG	0.652000													9	5					0	0	0.105934	0	0
PARP8	79668	broad.mit.edu	37	5	50090165	50090165	+	Splice_Site	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:50090165A>T	ENST00000281631.5	+	11	1020	c.863_splice	c.e11+1	p.R288_splice	PARP8_ENST00000503750.2_Splice_Site_p.R288_splice|PARP8_ENST00000514067.2_Splice_Site_p.R288_splice|PARP8_ENST00000505554.1_Splice_Site_p.R267_splice|PARP8_ENST00000505697.2_Splice_Site_p.R288_splice|PARP8_ENST00000514342.2_Splice_Site_p.R41_splice|PARP8_ENST00000511363.2_3'UTR	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	288						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				TACTTTGCGCAGGTTGGTAAC	0.398000													41	43					0	0	0.301197	0	0
KDR	3791	broad.mit.edu	37	4	55964401	55964401	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:55964401G>T	ENST00000263923.4	-	17	2707	c.2412C>A	c.(2410-2412)atC>atA	p.I804I		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	804					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GATCCATGACGATGGACAAGT	0.483000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			25	135					4.4004e-07	4.79692e-07	0.279207	1	0
SBSN	374897	broad.mit.edu	37	19	36018907	36018907	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:36018907C>A	ENST00000452271.2	-	1	305	c.277G>T	c.(277-279)Ggc>Tgc	p.G93C	SBSN_ENST00000518157.1_Missense_Mutation_p.G93C	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	93	Ala/Gly/His-rich.					extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TTGTCCATGCCGTGGTTGAGC	0.557000													25	96					8.24728e-16	1.0421e-15	0.309145	1	0
KIF20B	9585	broad.mit.edu	37	10	91514305	91514305	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:91514305A>G	ENST00000416354.1	+	26	4540	c.4468A>G	c.(4468-4470)Aag>Gag	p.K1490E	KIF20B_ENST00000260753.4_Missense_Mutation_p.K1420E|KIF20B_ENST00000478929.1_3'UTR|KIF20B_ENST00000394289.2_Missense_Mutation_p.K1460E|KIF20B_ENST00000371728.3_Missense_Mutation_p.K1460E			Q96Q89	KI20B_HUMAN	kinesin family member 20B	1460					cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	58						TGCTGATAGAAAGAAATGGTT	0.323000													55	3					0	0	0.323286	0	0
C19orf69	100170765	broad.mit.edu	37	19	41950079	41950079	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:41950079C>A	ENST00000378187.2	+	2	355	c.343C>A	c.(343-345)Ctg>Atg	p.L115M		NM_001130514.1	NP_001123986.1	A6NGS2	CS069_HUMAN	chromosome 19 open reading frame 69	115	Glu-rich.																GGAGGAACACCTGGAGGCCTG	0.537000													24	12					4.7796e-09	5.34577e-09	0.309145	1	0
SH3BP4	23677	broad.mit.edu	37	2	235951704	235951704	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:235951704A>T	ENST00000409212.1	+	4	2798	c.2291A>T	c.(2290-2292)gAg>gTg	p.E764V	SH3BP4_ENST00000392011.2_Missense_Mutation_p.E764V|SH3BP4_ENST00000344528.4_Missense_Mutation_p.E764V			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	764					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CTGCTCATGGAGAACATCAGC	0.632000													26	31					0	0	0.183431	0	0
BAHD1	22893	broad.mit.edu	37	15	40757559	40757559	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:40757559C>G	ENST00000561234.1	+	6	2334	c.2075C>G	c.(2074-2076)tCg>tGg	p.S692W	RP11-64K12.8_ENST00000559730.1_RNA|BAHD1_ENST00000416165.1_Missense_Mutation_p.S693W|BAHD1_ENST00000560846.1_Missense_Mutation_p.S690W			Q8TBE0	BAHD1_HUMAN	bromo adjacent homology domain containing 1	693	BAH.				heterochromatin formation|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin silencing complex|chromosome	chromatin binding|DNA binding|protein binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(3)|lung(10)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	28		all_cancers(109;8.28e-19)|all_epithelial(112;2.64e-15)|Lung NSC(122;5.14e-11)|all_lung(180;1.27e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.46e-06)|BRCA - Breast invasive adenocarcinoma(123;0.08)		GTGTTTGCATCGCGACATCAG	0.537000													11	44					0	0	0.080935	0	0
OR10A2	341276	broad.mit.edu	37	11	6891839	6891839	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:6891839A>C	ENST00000307322.4	+	1	916	c.854A>C	c.(853-855)aAg>aCg	p.K285T		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	285					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		AACGAGGTGAAGAATGCCCTC	0.448000													39	153					0	0	0.268233	0	0
LMAN1L	79748	broad.mit.edu	37	15	75116745	75116745	+	Silent	SNP	G	G	T	rs145391326		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:75116745G>T	ENST00000309664.5	+	13	1516	c.1377G>T	c.(1375-1377)tcG>tcT	p.S459S	LMAN1L_ENST00000379709.3_Silent_p.S447S|RP11-414J4.2_ENST00000564823.1_RNA	NM_021819.2	NP_068591.2	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like	459						ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GGGCCTCCTCGTGCCTGCAGC	0.597000													30	88					9.04072e-19	1.18691e-18	0.183431	1	0
PBXIP1	57326	broad.mit.edu	37	1	154919082	154919082	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:154919082C>T	ENST00000368463.3	-	10	1139	c.1068G>A	c.(1066-1068)ggG>ggA	p.G356G	PBXIP1_ENST00000368465.1_Silent_p.G327G|PBXIP1_ENST00000542459.1_Silent_p.G201G|PBXIP1_ENST00000539880.1_Silent_p.G183G	NM_020524.2	NP_065385.2	Q96AQ6	PBIP1_HUMAN	pre-B-cell leukemia homeobox interacting protein 1	356			G -> D (in dbSNP:rs2061690).		cell differentiation|multicellular organismal development|negative regulation of transcription, DNA-dependent	cytosol|microtubule|nucleus	protein binding|transcription corepressor activity			breast(1)|kidney(2)|large_intestine(6)|lung(13)|prostate(1)|urinary_tract(1)	24	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GGCCTCTACCCCCACTGAGGC	0.672000													37	115					0	0	0.246493	0	0
HNRNPM	4670	broad.mit.edu	37	19	8551153	8551153	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:8551153G>T	ENST00000348943.3	+	15	1956	c.1724G>T	c.(1723-1725)gGt>gTt	p.G575V	HNRNPM_ENST00000325495.4_Missense_Mutation_p.G614V	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	614	27 X 6 AA repeats of [GEVSTPAN]-[ILMV]- [DE]-[RH]-[MLVI]-[GAV].				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						ATGGGTGGCGGTGGCGGTGCC	0.677000													41	3					2.24722e-20	3.02199e-20	0.323286	1	0
CCDC108	255101	broad.mit.edu	37	2	219888941	219888941	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:219888941G>T	ENST00000341552.5	-	15	2474	c.2391C>A	c.(2389-2391)agC>agA	p.S797R	CCDC108_ENST00000441968.1_Missense_Mutation_p.S797R|CCDC108_ENST00000453220.1_Missense_Mutation_p.S797R	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	797						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAGGAGCAGGCTGCGGTAGG	0.642000													8	32					1.12685e-05	1.20009e-05	0.307466	1	0
TGIF2LX	90316	broad.mit.edu	37	X	89177587	89177587	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:89177587C>A	ENST00000561129.2	+	1	633	c.503C>A	c.(502-504)tCa>tAa	p.S168*	TGIF2LX_ENST00000283891.5_Nonsense_Mutation_p.S168*			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	168						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						GGCCAGATGTCAAGAGAGAAG	0.592000													44	4					2.14674e-31	3.25426e-31	0.323286	1	0
MOXD1	26002	broad.mit.edu	37	6	132694056	132694056	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:132694056C>A	ENST00000367963.3	-	3	610	c.492G>T	c.(490-492)agG>agT	p.R164S	MOXD1_ENST00000336749.3_Missense_Mutation_p.R96S	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	164					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TCTTGGTGCCCCTATTGGAGT	0.473000													84	45					7.7321e-48	1.29021e-47	0.323286	1	0
SUCO	51430	broad.mit.edu	37	1	172501625	172501625	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:172501625T>G	ENST00000367723.3	+	1	137	c.13T>G	c.(13-15)Ttg>Gtg	p.L5V		NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		GAGAGGATTCTTGGCACGCCC	0.502000													8	63					0	0	0.069234	0	0
LARP1	23367	broad.mit.edu	37	5	154185566	154185566	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:154185566A>G	ENST00000336314.4	+	15	2465	c.2441A>G	c.(2440-2442)cAt>cGt	p.H814R		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	891							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CACGTCTACCATAAGTATCGT	0.507000													64	107					0	0	0.323286	0	0
BASP1	10409	broad.mit.edu	37	5	17275491	17275491	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:17275491G>C	ENST00000322611.3	+	2	426	c.166G>C	c.(166-168)Gag>Cag	p.E56Q		NM_001271606.1|NM_006317.3	NP_001258535.1|NP_006308.3	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein 1	56					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding			endometrium(1)|lung(8)	9						GGAGGGCAAGGAGAAGCCCGA	0.716000													6	14					0	0	0.080935	0	0
BRICD5	283870	broad.mit.edu	37	16	2259431	2259431	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:2259431G>C	ENST00000328540.3	-	6	1735	c.619C>G	c.(619-621)Ctc>Gtc	p.L207V	BRICD5_ENST00000562360.1_Missense_Mutation_p.L239V	NM_182563.3	NP_872369.2			BRICHOS domain containing 5																		TCGATGCAGAGATAAATCAGC	0.642000													9	10					0	0	0.132662	0	0
NTRK1	4914	broad.mit.edu	37	1	156849054	156849054	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:156849054G>T	ENST00000368196.3	+	14	2048	c.1928G>T	c.(1927-1929)cGg>cTg	p.R643L	NTRK1_ENST00000524377.1_Missense_Mutation_p.R649L|NTRK1_ENST00000392302.2_Missense_Mutation_p.R613L|NTRK1_ENST00000358660.3_Missense_Mutation_p.R646L	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	649	Protein kinase.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TTTGTGCACCGGGACCTGGCC	0.612000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			43	72					5.44703e-19	7.18154e-19	0.279185	1	0
KCTD8	386617	broad.mit.edu	37	4	44177184	44177184	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:44177184C>A	ENST00000360029.3	-	2	1328	c.1045G>T	c.(1045-1047)Ggg>Tgg	p.G349W		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	349						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						CAGGAAGTCCCACTTTCACTT	0.458000										HNSCC(17;0.042)			70	84					2.42712e-22	3.36022e-22	0.323286	1	0
NBEAP1	606	broad.mit.edu	37	15	20874895	20874895	+	RNA	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:20874895G>T	ENST00000556948.1	-	0	353																											TTCCTATTCTGCATATGGTGG	0.333000													10	171					0.000673444	0.000698011	0.069234	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64644259	64644259	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:64644259T>G	ENST00000498707.1	-	4	1230	c.888A>C	c.(886-888)gaA>gaC	p.E296D	ADAMTS9_ENST00000459780.1_Missense_Mutation_p.E296D|ADAMTS9_ENST00000295903.4_Missense_Mutation_p.E296D	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	296	Peptidase M12B.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CCACCAAGACTTCTACAAACC	0.378000													9	267					0	0	0.058154	0	0
C10orf137	26098	broad.mit.edu	37	10	127438099	127438099	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:127438099T>C	ENST00000337623.3	+	21	3245	c.3140T>C	c.(3139-3141)cTa>cCa	p.L1047P	C10orf137_ENST00000356792.4_Missense_Mutation_p.L1081P|RP11-383C5.7_ENST00000449436.1_RNA|RP11-383C5.7_ENST00000602030.1_RNA|RP11-383C5.7_ENST00000601363.1_RNA|RP11-383C5.7_ENST00000600784.1_RNA|RP11-383C5.7_ENST00000594025.1_RNA|RP11-383C5.7_ENST00000593871.1_RNA	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	1081					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AGAGTACAGCTAGAGAGAGTA	0.438000													50	77					0	0	0.323286	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48918082	48918082	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:48918082C>A	ENST00000311378.4	+	2	1961	c.1433C>A	c.(1432-1434)tCg>tAg	p.S478*	RP11-506D12.5_ENST00000572491.2_RNA|WFIKKN2_ENST00000426127.1_Nonsense_Mutation_p.S385*	NM_175575.5	NP_783165.1	Q8TEU8	WFKN2_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	478	NTR.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(13)|ovary(4)|skin(1)	29			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			GAGCCTGACTCGGGCCGCGCC	0.602000													27	42					2.61193e-14	3.22663e-14	0.144211	1	0
PRL	5617	broad.mit.edu	37	6	22287778	22287778	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:22287778C>G	ENST00000306482.1	-	5	1055	c.537G>C	c.(535-537)tcG>tcC	p.S179S	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	179					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					ATGGAAGTCCCGACCAGACAG	0.408000													30	92					0	0	0.183431	0	0
IGKV1-8	28942	broad.mit.edu	37	2	89292063	89292063	+	RNA	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:89292063A>T	ENST00000495489.1	-	0	262																											AAGTGGATGCAGCATAGATCA	0.502000													104	171					0	0	0.323286	0	0
UGT1A1	54658	broad.mit.edu	37	2	234669236	234669236	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:234669236G>T	ENST00000360418.3	+	1	303	c.303G>T	c.(301-303)gaG>gaT	p.E101D	UGT1A4_ENST00000373409.3_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A1_ENST00000305208.5_Missense_Mutation_p.E101D|UGT1A3_ENST00000482026.1_Intron			P22309	UD11_HUMAN		101					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding	p.E101D(1)		breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	ATGTTTTTGAGAATGATTCTT	0.423000													22	219					1.87028e-06	2.02173e-06	0.234183	1	0
SLC9A9	285195	broad.mit.edu	37	3	143371170	143371170	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:143371170C>A	ENST00000316549.6	-	6	890	c.682G>T	c.(682-684)Gtc>Ttc	p.V228F		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	228					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						TCAGGGTCGACGTGCAGTTCA	0.473000													21	38					6.12954e-19	8.06422e-19	0.309145	1	0
GPR37	2861	broad.mit.edu	37	7	124386859	124386859	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:124386859C>A	ENST00000303921.2	-	2	2212	c.1562G>T	c.(1561-1563)gGg>gTg	p.G521V		NM_005302.2	NP_005293.1	O15354	GPR37_HUMAN	G protein-coupled receptor 37 (endothelin receptor type B-like)	521						endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						CTGTGAAACCCCTGTAGCCAT	0.418000													76	80					7.83748e-43	1.28223e-42	0.323286	1	0
TLK2	11011	broad.mit.edu	37	17	60683536	60683536	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:60683536G>A	ENST00000582809.1	+	21	2161	c.1458G>A	c.(1456-1458)aaG>aaA	p.K486K	TLK2_ENST00000542523.1_Silent_p.K603K|TLK2_ENST00000326270.9_Silent_p.K657K|TLK2_ENST00000346027.5_Silent_p.K635K|TLK2_ENST00000343388.7_Silent_p.K603K			Q86UE8	TLK2_HUMAN	tousled-like kinase 2	657	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(10)|kidney(4)|large_intestine(6)|liver(2)|lung(10)|prostate(1)|stomach(1)|urinary_tract(1)	39						AACCACCAAAGATCTCAAATA	0.363000													11	34					0	0	0.105934	0	0
OR2M2	391194	broad.mit.edu	37	1	248343651	248343651	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248343651C>A	ENST00000359682.2	+	1	364	c.364C>A	c.(364-366)Cgc>Agc	p.R122S		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GGCTTATGACCGCTATATTGC	0.408000													76	325					1.86864e-30	2.80387e-30	0.323286	1	0
NUP85	79902	broad.mit.edu	37	17	73230881	73230881	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:73230881C>T	ENST00000447371.2	+	16	1685	c.1261C>T	c.(1261-1263)Cag>Tag	p.Q421*	NUP85_ENST00000245544.4_Nonsense_Mutation_p.Q589*|NUP85_ENST00000541827.1_Nonsense_Mutation_p.Q543*|NUP85_ENST00000579324.1_Nonsense_Mutation_p.Q477*|NUP85_ENST00000579298.1_Nonsense_Mutation_p.Q544*|NUP85_ENST00000540768.1_Nonsense_Mutation_p.Q192*			Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	589					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			GGAACAGAAACAGGTGAAGGT	0.517000													20	252					0	0	0.264190	0	0
SVEP1	79987	broad.mit.edu	37	9	113312282	113312282	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:113312282G>T	ENST00000401783.2	-	2	970	c.634C>A	c.(634-636)Cga>Aga	p.R212R	SVEP1_ENST00000374469.1_Silent_p.R189R|SVEP1_ENST00000374461.1_Silent_p.R189R|SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000302728.8_Silent_p.R212R	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	212	VWFA.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CCTGAATCTCGCAGTGACGCT	0.453000													65	83					2.18419e-29	3.24123e-29	0.323286	1	0
MUC17	140453	broad.mit.edu	37	7	100684661	100684661	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100684661C>T	ENST00000306151.4	+	3	10028	c.9964C>T	c.(9964-9966)Cct>Tct	p.P3322S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3322	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CAGTTCATCTCCTCCAATTGC	0.498000													126	99					0	0	0.323286	0	0
MUC16	94025	broad.mit.edu	37	19	9064622	9064622	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:9064622A>T	ENST00000397910.4	-	3	23027	c.22824T>A	c.(22822-22824)tcT>tcA	p.S7608S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7610	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGAGGAGGCAGAAATCCTGG	0.478000													17	198					0	0	0.160694	0	0
KRTAP4-3	85290	broad.mit.edu	37	17	39324162	39324162	+	Missense_Mutation	SNP	C	C	G	rs66489415		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39324162C>G	ENST00000391356.2	-	1	262	c.263G>C	c.(262-264)aGc>aCc	p.S88T		NM_033187.1	NP_149443.1	Q9BYR4	KRA43_HUMAN	keratin associated protein 4-3	88	29 X 5 AA repeats of C-C-[GIKRQVH]-[SPT]- [STA].					keratin filament				breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	12		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			tttgcagcagctggagataca	0.592000													18	13					0	0	0.294199	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947584	57947584	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:57947584T>C	ENST00000335397.3	+	3	984	c.668T>C	c.(667-669)gTg>gCg	p.V223A		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				TTTATCATCGTGGCCATCATG	0.512000													194	112					0	0	0.323286	0	0
OR9G4	283189	broad.mit.edu	37	11	56511219	56511219	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:56511219G>T	ENST00000302957.3	-	1	68	c.69C>A	c.(67-69)atC>atA	p.I23I		NM_001005284.1	NP_001005284.1	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G, member 4	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						ATTCAGTCAGGATGGTGCAAT	0.423000													63	155					3.30712e-30	4.9479e-30	0.323286	1	0
SEMA3G	56920	broad.mit.edu	37	3	52475604	52475604	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:52475604T>C	ENST00000231721.2	-	6	652	c.653A>G	c.(652-654)cAg>cGg	p.Q218R		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	218	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CAAGAGACTCTGGTCAGAGTC	0.637000													28	15					0	0	0.193644	0	0
CD2	914	broad.mit.edu	37	1	117297470	117297470	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:117297470A>T	ENST00000369478.3	+	2	387	c.279A>T	c.(277-279)aaA>aaT	p.K93N	CD2_ENST00000369477.1_Missense_Mutation_p.K93N	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	93	Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	GAACTCTGAAAATTAAGCATC	0.284000													22	38					0	0	0.264190	0	0
GCK	2645	broad.mit.edu	37	7	44192957	44192957	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:44192957C>G	ENST00000403799.3	-	2	620	c.151G>C	c.(151-153)Gaa>Caa	p.E51Q	GCK_ENST00000395796.3_Missense_Mutation_p.E50Q|GCK_ENST00000345378.2_Missense_Mutation_p.E52Q|GCK_ENST00000437084.1_Missense_Mutation_p.E51Q	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	51					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						CTGGCCTCTTCATGGGTCTCC	0.602000													53	71					0	0	0.323286	0	0
TRAV8-1	28685	broad.mit.edu	37	14	22265845	22265845	+	RNA	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:22265845A>G	ENST00000390430.2	+	0	260																											TTGGGATGCAACTATTCCTAT	0.473000													33	429					0	0	0.183431	0	0
SPP2	6694	broad.mit.edu	37	2	234969063	234969063	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:234969063G>T	ENST00000168148.3	+	4	472	c.384G>T	c.(382-384)caG>caT	p.Q128H	SPP2_ENST00000373368.1_Missense_Mutation_p.Q128H	NM_006944.2	NP_008875.1	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa	128					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		AGCAGGTGCAGGGCGTGCATG	0.567000													23	260					1.1804e-14	1.46579e-14	0.294199	1	0
GABRB1	2560	broad.mit.edu	37	4	47405654	47405654	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:47405654C>A	ENST00000295454.3	+	7	1053	c.761C>A	c.(760-762)tCt>tAt	p.S254Y	GABRB1_ENST00000538619.1_Missense_Mutation_p.S184Y	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	254					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TACATGCCTTCTACACTGATT	0.418000													40	58					2.26627e-22	3.13893e-22	0.257332	1	0
GRIK4	2900	broad.mit.edu	37	11	120831681	120831681	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:120831681G>T	ENST00000527524.2	+	17	2225	c.1938G>T	c.(1936-1938)gtG>gtT	p.V646V	GRIK4_ENST00000438375.2_Silent_p.V646V			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	646					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	TCCTGACCGTGCAGCGCATGG	0.547000													40	26					2.77807e-22	3.83408e-22	0.312237	1	0
LRP2	4036	broad.mit.edu	37	2	170063602	170063602	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:170063602C>A	ENST00000263816.3	-	39	6913	c.6628G>T	c.(6628-6630)Ggg>Tgg	p.G2210W		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2210					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGTCTCTGCCCATAGTCAGCC	0.493000													167	217					6.85087e-58	1.1913e-57	0.323286	1	0
LOXHD1	125336	broad.mit.edu	37	18	44085920	44085920	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:44085920G>T	ENST00000536736.1	-	36	5572	c.5573C>A	c.(5572-5574)gCc>gAc	p.A1858D	LOXHD1_ENST00000441893.2_Missense_Mutation_p.A791D|LOXHD1_ENST00000398722.4_Missense_Mutation_p.A1642D|LOXHD1_ENST00000300591.6_Missense_Mutation_p.A809D|LOXHD1_ENST00000441551.2_Missense_Mutation_p.A1714D|LOXHD1_ENST00000398686.4_Missense_Mutation_p.A159D|LOXHD1_ENST00000582408.1_Missense_Mutation_p.A747D|LOXHD1_ENST00000579038.1_Missense_Mutation_p.A713D|LOXHD1_ENST00000398705.2_Missense_Mutation_p.A159D	NM_144612.6	NP_653213.6	Q8IVV2	LOXH1_HUMAN	lipoxygenase homology domains 1	1642	PLAT 13.				sensory perception of sound	stereocilium	protein binding			NS(3)|autonomic_ganglia(1)|breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(2)|pancreas(1)|prostate(4)|skin(4)|stomach(1)	36						CTGCTTCAGGGCCAGTGTCCC	0.567000													39	4					2.95478e-19	3.90899e-19	0.268233	1	0
MYCBP2	23077	broad.mit.edu	37	13	77664259	77664259	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:77664259C>A	ENST00000407578.2	-	60	10773	c.10507G>T	c.(10507-10509)Gtt>Ttt	p.V3503F	MYCBP2_ENST00000544440.2_Missense_Mutation_p.V3465F|MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2_ENST00000357337.6_Missense_Mutation_p.V3465F	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3465					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CCACTGTTAACTCTTCTTCTA	0.318000													44	171					6.17242e-35	9.63507e-35	0.323286	1	0
OLFML3	56944	broad.mit.edu	37	1	114524161	114524161	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:114524161C>T	ENST00000369551.1	+	4	1219	c.931C>T	c.(931-933)Ctc>Ttc	p.L311F	OLFML3_ENST00000320334.4_Missense_Mutation_p.L331F|OLFML3_ENST00000491700.1_3'UTR|OLFML3_ENST00000393300.2_Missense_Mutation_p.L311F			Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3	331	Olfactomedin-like.				multicellular organismal development	extracellular region				breast(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)|urinary_tract(1)	14	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGTGGGACCCTCTATGTCGT	0.582000													42	75					0	0	0.323286	0	0
CLDN8	9073	broad.mit.edu	37	21	31588216	31588216	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:31588216C>A	ENST00000399899.1	-	1	175	c.28G>T	c.(28-30)Ggg>Tgg	p.G10W	CLDN8_ENST00000286809.1_Missense_Mutation_p.G10W	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	10					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity			NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						AGAAACAGCCCAGCGATTTCT	0.507000													34	52					4.18559e-23	5.83908e-23	0.323286	1	0
DOCK7	85440	broad.mit.edu	37	1	63113986	63113986	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:63113986C>G	ENST00000251157.5	-	6	556	c.523G>C	c.(523-525)Gac>Cac	p.D175H	DOCK7_ENST00000404627.2_Missense_Mutation_p.D175H|DOCK7_ENST00000340370.5_Missense_Mutation_p.D175H	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	175					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						CTTTTAAGGTCATCCTGTCAT	0.294000													17	51					0	0	0.175082	0	0
CDH8	1006	broad.mit.edu	37	16	61687535	61687535	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:61687535C>A	ENST00000577390.1	-	12	3331	c.2377G>T	c.(2377-2379)Ggt>Tgt	p.G793C	CDH8_ENST00000299345.6_Intron|CDH8_ENST00000577730.1_Intron	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	793					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TCACTTTCACCAACAGAGTAG	0.448000													115	8					1.49884e-55	2.5817e-55	0.323286	1	0
PEG3	5178	broad.mit.edu	37	19	57327366	57327366	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:57327366T>C	ENST00000326441.9	-	10	2807	c.2444A>G	c.(2443-2445)cAt>cGt	p.H815R	PEG3_ENST00000423103.2_Missense_Mutation_p.H815R|PEG3_ENST00000598410.1_Missense_Mutation_p.H691R|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000391708.3_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.H689R|ZIM2_ENST00000599935.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	815					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AACTCTCTGATGGTTGATAGC	0.468000													261	15					0	0	0.323286	0	0
KRT39	390792	broad.mit.edu	37	17	39116593	39116593	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39116593T>G	ENST00000355612.2	-	6	1192	c.1157A>C	c.(1156-1158)aAg>aCg	p.K386T	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	386	Coil 2.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				CAGCCGGGACTTGACGTCCAG	0.483000													87	232					0	0	0.323286	0	0
TENM2	57451	broad.mit.edu	37	5	167674989	167674989	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:167674989G>T	ENST00000519204.1	+	26	6800	c.6682G>T	c.(6682-6684)Gac>Tac	p.D2228Y	TENM2_ENST00000518659.1_Missense_Mutation_p.D2349Y|TENM2_ENST00000520394.1_Missense_Mutation_p.D2110Y|TENM2_ENST00000403607.2_Missense_Mutation_p.D2173Y|TENM2_ENST00000545108.1_Missense_Mutation_p.D2348Y					teneurin transmembrane protein 2																		ACTGTACTACGACCTCCAGGG	0.547000													27	55					7.76418e-22	1.06538e-21	0.324025	1	0
XIRP1	165904	broad.mit.edu	37	3	39227079	39227079	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:39227079G>T	ENST00000340369.3	-	2	4086	c.3858C>A	c.(3856-3858)ccC>ccA	p.P1286P	XIRP1_ENST00000396251.1_3'UTR|XIRP1_ENST00000421646.1_5'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1286	Pro-rich.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGTCCTTCAGGGGCTCAGAGG	0.612000													55	41					5.88917e-42	9.57415e-42	0.323286	1	0
AK9	221264	broad.mit.edu	37	6	109819103	109819103	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:109819103G>A	ENST00000424296.2	-	37	5188	c.5112C>T	c.(5110-5112)gaC>gaT	p.D1704D	RP5-919F19.5_ENST00000423747.1_RNA	NM_001145128.2	NP_001138600.2			adenylate kinase 9																		TGGGGATCATGTCAGCAGATG	0.463000													35	86					0	0	0.214465	0	0
MRRF	92399	broad.mit.edu	37	9	125042807	125042807	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:125042807A>T	ENST00000344641.3	+	3	581	c.270A>T	c.(268-270)gaA>gaT	p.E90D	MRRF_ENST00000394315.3_Missense_Mutation_p.E90D|MRRF_ENST00000373723.4_Missense_Mutation_p.E90D|MRRF_ENST00000373728.1_Missense_Mutation_p.E90D|MRRF_ENST00000546115.1_Missense_Mutation_p.E90D|MRRF_ENST00000373730.3_Missense_Mutation_p.E90D|MRRF_ENST00000373729.1_Missense_Mutation_p.E46D|MRRF_ENST00000373727.1_Missense_Mutation_p.E90D|MRRF_ENST00000297908.3_Intron	NM_138777.3	NP_620132.1	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor	90					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	12						AGGTGAATGAAGAAATGAAGT	0.403000													34	44					0	0	0.246493	0	0
ACSM5	54988	broad.mit.edu	37	16	20422935	20422935	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:20422935C>A	ENST00000331849.4	+	2	276	c.129C>A	c.(127-129)agC>agA	p.S43R	ACSM5_ENST00000575584.1_Missense_Mutation_p.S43R	NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	43					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						AAGCCATCAGCCTGGGAAGGC	0.572000													59	4					5.73332e-34	8.89138e-34	0.323286	1	0
C7orf34	135927	broad.mit.edu	37	7	142637627	142637627	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142637627A>T	ENST00000409607.3	+	2	438	c.397A>T	c.(397-399)Agg>Tgg	p.R133W		NM_178829.4	NP_849151.2	Q96L11	CG034_HUMAN	chromosome 7 open reading frame 34	108						extracellular region				large_intestine(1)|lung(4)	5	Melanoma(164;0.059)					AGGGCCATTGAGGCGGACATT	0.542000													150	364					0	0	0.323286	0	0
LRP2	4036	broad.mit.edu	37	2	170097528	170097528	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:170097528G>T	ENST00000263816.3	-	25	4300	c.4015C>A	c.(4015-4017)Ccc>Acc	p.P1339T	LRP2_ENST00000443831.1_Missense_Mutation_p.P1202T	NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1339	LDL-receptor class A 15.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GTCCCATTGGGGCAGTCAAAG	0.488000													85	138					3.24273e-39	5.20619e-39	0.323286	1	0
ZNF99	7652	broad.mit.edu	37	19	22940569	22940569	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:22940569A>G	ENST00000397104.3	-	5	1868	c.1869T>C	c.(1867-1869)ttT>ttC	p.F623F	ZNF99_ENST00000596209.1_Silent_p.F714F					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AGGACTGGCTAAAAGCTTTGC	0.373000													33	152					0	0	0.214465	0	0
KRT16P3	644945	broad.mit.edu	37	17	20405855	20405855	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:20405855C>A	ENST00000580113.1	-	0	1008																											GGGTGGTGGCCATTACTGGTG	0.537000													25	44					3.73148e-12	4.44305e-12	0.125774	1	0
TTC31	64427	broad.mit.edu	37	2	74718475	74718475	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:74718475A>T	ENST00000410003.1	+	7	666	c.657A>T	c.(655-657)ccA>ccT	p.P219P	TTC31_ENST00000463189.1_3'UTR|TTC31_ENST00000442235.2_Silent_p.P75P|TTC31_ENST00000233623.5_Silent_p.P219P			Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	219							binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						CTGGAAACCCAGTTCAGGGAC	0.532000													89	131					0	0	0.323286	0	0
RPUSD3	285367	broad.mit.edu	37	3	9880781	9880781	+	Missense_Mutation	SNP	G	G	A	rs146799821	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:9880781G>A	ENST00000383820.5	-	8	800	c.799C>T	c.(799-801)Cgt>Tgt	p.R267C	RPUSD3_ENST00000433535.2_Missense_Mutation_p.R252C|TTLL3_ENST00000455274.1_Intron|RPUSD3_ENST00000424438.1_Intron	NM_173659.3	NP_775930.2	Q6P087	RUSD3_HUMAN	RNA pseudouridylate synthase domain containing 3	267					pseudouridine synthesis		pseudouridine synthase activity|RNA binding			central_nervous_system(2)|endometrium(3)|lung(2)	7	Medulloblastoma(99;0.227)					GTGCCCACACGGGCAGAGTAC	0.577000													7	98					0	0	0.278610	0	0
ASMT	438	broad.mit.edu	37	X	1746597	1746597	+	Splice_Site	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:1746597G>A	ENST00000381241.3	+	4	575	c.374_splice	c.e4-1	p.E126_splice	ASMT_ENST00000381233.3_Splice_Site_p.E126_splice|ASMT_ENST00000381229.4_Splice_Site_p.E126_splice	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	126					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TTTTCTTAGAGAAGGAAGGAA	0.393000													59	243					0	0	0.323286	0	0
SASH1	23328	broad.mit.edu	37	6	148795359	148795359	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:148795359G>T	ENST00000367467.3	+	7	1102		c.e7+1			NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1								protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		ACTTGCTAGGGTAAGCATGCA	0.418000													12	26					7.03913e-09	7.85309e-09	0.093190	1	0
SYCP1	6847	broad.mit.edu	37	1	115537618	115537618	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:115537618A>G	ENST00000369522.3	+	32	3149	c.2909A>G	c.(2908-2910)gAa>gGa	p.E970G	SYCP1_ENST00000369518.1_Missense_Mutation_p.E970G|SYCP1_ENST00000477590.1_3'UTR	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	970					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAACTAAAAGAAGCTGAAAAG	0.348000													58	42					0	0	0.323286	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74507269	74507269	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:74507269G>C	ENST00000354431.4	-	7	1537	c.1346C>G	c.(1345-1347)gCt>gGt	p.A449G	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.A449G	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	449										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TCTTTCTCGAGCAACTTGTGC	0.318000													132	324					0	0	0.323286	0	0
SLITRK1	114798	broad.mit.edu	37	13	84455387	84455387	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:84455387T>C	ENST00000377084.2	-	1	1141	c.256A>G	c.(256-258)Agt>Ggt	p.S86G		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	86						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		ATGTGCAAACTAACCGCATTA	0.448000													20	85					0	0	0.324025	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821360	5821360	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:5821360G>T	ENST00000381095.3	-	5	1986	c.1359C>A	c.(1357-1359)gcC>gcA	p.A453A	NLGN4X_ENST00000381092.1_Silent_p.A453A|NLGN4X_ENST00000381093.2_Silent_p.A473A|NLGN4X_ENST00000538097.1_Silent_p.A453A|NLGN4X_ENST00000275857.6_Silent_p.A453A	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	453					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						CGGTGGCCACGGCGGGGGCCA	0.592000													11	1					1.414e-09	1.59999e-09	0.193644	1	0
SF3B2	10992	broad.mit.edu	37	11	65819874	65819874	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:65819874G>T	ENST00000528302.1	+	1	73	c.19G>T	c.(19-21)Gag>Tag	p.E7*	SF3B2_ENST00000322535.6_Nonsense_Mutation_p.E7*			Q13435	SF3B2_HUMAN	splicing factor 3b, subunit 2, 145kDa	7					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	41						GGAGCATCCCGAGCCTCCCAA	0.687000													5	10					4.096e-09	4.59946e-09	0.217242	1	0
ZNF831	128611	broad.mit.edu	37	20	57767137	57767137	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:57767137C>G	ENST00000371030.2	+	1	1063	c.1063C>G	c.(1063-1065)Cag>Gag	p.Q355E		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	355						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CAGCGCGGAGCAGCCGCATGC	0.756000													5	8					0	0	0.307466	0	0
CEP250	11190	broad.mit.edu	37	20	34091361	34091361	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:34091361G>T	ENST00000397527.1	+	30	5884	c.5164G>T	c.(5164-5166)Ggg>Tgg	p.G1722W	CEP250_ENST00000342580.4_Missense_Mutation_p.G1666W	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1722	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			AGCACAGCGCGGGAGCCTAGA	0.572000													73	296					3.31162e-33	5.1178e-33	0.323286	1	0
CADPS	8618	broad.mit.edu	37	3	62518713	62518713	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:62518713C>A	ENST00000383710.4	-	13	2473	c.2124G>T	c.(2122-2124)caG>caT	p.Q708H	CADPS_ENST00000283269.9_Missense_Mutation_p.Q708H|CADPS_ENST00000357948.3_Missense_Mutation_p.Q691H	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	708					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GTACAAACACCTGGCCAGGAC	0.488000													5	261					0.184627	0.186433	0.184627	1	0
PAPPA2	60676	broad.mit.edu	37	1	176526166	176526166	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:176526166G>A	ENST00000367662.3	+	2	1872	c.708G>A	c.(706-708)ccG>ccA	p.P236P	PAPPA2_ENST00000367661.3_Silent_p.P236P	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	236					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						AGAGTCCACCGGAGGAAAGCA	0.537000													168	398					0	0	0.323286	0	0
CD33	945	broad.mit.edu	37	19	51728727	51728727	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51728727T>C	ENST00000262262.4	+	2	312	c.291T>C	c.(289-291)agT>agC	p.S97S	CD33_ENST00000421133.2_Intron|CD33_ENST00000436584.2_Intron|CD33_ENST00000391796.3_Silent_p.S97S	NM_001772.3	NP_001763.3	P20138	CD33_HUMAN	CD33 molecule	97	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	GGGATCCCAGTAGGAACAACT	0.498000													80	198					0	0	0.323286	0	0
LECT2	3950	broad.mit.edu	37	5	135288647	135288647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:135288647C>A	ENST00000274507.1	-	2	256	c.56G>T	c.(55-57)gGg>gTg	p.G19V	LECT2_ENST00000522943.1_Missense_Mutation_p.G19V|LECT2_ENST00000514447.2_Missense_Mutation_p.G19V|LECT2_ENST00000471827.1_5'UTR|LECT2_ENST00000512872.1_5'UTR	NM_002302.2	NP_002293.2	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2	19					chemotaxis|skeletal system development	cytoplasm|extracellular space				large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGCCCATGGCCCTGCCAGTGC	0.493000													86	104					3.62344e-47	6.02675e-47	0.323286	1	0
SNX14	57231	broad.mit.edu	37	6	86223586	86223586	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:86223586G>T	ENST00000314673.3	-	26	2761	c.2585C>A	c.(2584-2586)cCt>cAt	p.P862H	SNX14_ENST00000513865.1_Missense_Mutation_p.P581H|SNX14_ENST00000505648.1_Missense_Mutation_p.P810H|SNX14_ENST00000369627.2_Missense_Mutation_p.P853H|SNX14_ENST00000346348.3_Missense_Mutation_p.P809H|SNX14_ENST00000508980.1_5'UTR	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	862					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		GAGAGAGCGAGGTTCAGTGTT	0.294000													41	38					1.61863e-15	2.04108e-15	0.323286	1	0
KRT6A	3853	broad.mit.edu	37	12	52886967	52886967	+	Silent	SNP	G	G	T	rs11540285		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:52886967G>T	ENST00000330722.6	-	1	74	c.6C>A	c.(4-6)gcC>gcA	p.A2A		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	2	Head.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGGATGTGCTGGCCATGGTTC	0.622000													11	30					6.72482e-11	7.82373e-11	0.132662	1	0
SHANK1	50944	broad.mit.edu	37	19	51219698	51219698	+	Missense_Mutation	SNP	G	G	T	rs143340442		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51219698G>T	ENST00000293441.1	-	2	311	c.293C>A	c.(292-294)aCg>aAg	p.T98K	SHANK1_ENST00000391814.1_Missense_Mutation_p.T98K|SHANK1_ENST00000359082.3_Missense_Mutation_p.T98K	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	98					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CTGCTTGGCCGTCCAGATGGT	0.627000													22	30					5.35356e-11	6.23307e-11	0.264190	1	0
RFC3	5983	broad.mit.edu	37	13	34404010	34404010	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:34404010T>C	ENST00000380071.3	+	5	559	c.429T>C	c.(427-429)gaT>gaC	p.D143D	RFC3_ENST00000434425.1_Silent_p.D143D	NM_002915.3	NP_002906.1	P40938	RFC3_HUMAN	replication factor C (activator 1) 3, 38kDa	143					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|response to organophosphorus|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			lung(2)|skin(1)	3		Hepatocellular(188;0.0191)|Lung SC(185;0.0548)		all cancers(112;5.09e-06)|Epithelial(112;6.52e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00107)|OV - Ovarian serous cystadenocarcinoma(117;0.0285)|GBM - Glioblastoma multiforme(144;0.123)		TCACCAAAGATGCTCAGCATG	0.373000													133	19					0	0	0.323286	0	0
CSMD3	114788	broad.mit.edu	37	8	113697652	113697652	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:113697652A>G	ENST00000297405.5	-	15	2709	c.2465T>C	c.(2464-2466)tTt>tCt	p.F822S	CSMD3_ENST00000455883.2_Missense_Mutation_p.F718S|CSMD3_ENST00000352409.3_Missense_Mutation_p.F822S|CSMD3_ENST00000343508.3_Missense_Mutation_p.F782S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	822	CUB 4.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGTGATGTTAAAGCCACGTCC	0.378000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			51	81					0	0	0.323286	0	0
TMEM138	51524	broad.mit.edu	37	11	61133627	61133627	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:61133627G>T	ENST00000542946.1	+	3	438	c.239G>T	c.(238-240)gGg>gTg	p.G80V	TMEM138_ENST00000381787.2_Missense_Mutation_p.G22V|TMEM138_ENST00000278826.6_Missense_Mutation_p.G80V|TMEM138_ENST00000540194.1_3'UTR			Q9NPI0	TM138_HUMAN	transmembrane protein 138	80						integral to membrane				central_nervous_system(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5						AAGTTCAAAGGGACCATCATC	0.433000													25	78					5.35047e-06	5.73569e-06	0.279207	1	0
FAM47C	442444	broad.mit.edu	37	X	37029517	37029517	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:37029517A>G	ENST00000358047.3	+	1	3086	c.3034A>G	c.(3034-3036)Aag>Gag	p.K1012E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	1012										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TGACTCTGTTAAGACTCCTAT	0.403000													96	112					0	0	0.323286	0	0
CDH10	1008	broad.mit.edu	37	5	24511552	24511552	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:24511552C>G	ENST00000264463.4	-	6	1393	c.886G>C	c.(886-888)Gct>Cct	p.A296P		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	296	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CCAGTGTCAGCATCAGTTGCT	0.423000										HNSCC(23;0.051)			103	134					0	0	0.323286	0	0
SLIT2	9353	broad.mit.edu	37	4	20611664	20611664	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:20611664C>A	ENST00000504154.1	+	34	3973	c.3721C>A	c.(3721-3723)Cac>Aac	p.H1241N	SLIT2_ENST00000273739.5_Missense_Mutation_p.H1254N|SLIT2_ENST00000503823.1_Missense_Mutation_p.H1233N|SLIT2_ENST00000503837.1_Missense_Mutation_p.H1237N	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1241	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TGGAAACTTCCACATTGTGGA	0.393000													13	44					8.73648e-17	1.11621e-16	0.203993	1	0
SCN3A	6328	broad.mit.edu	37	2	165994467	165994467	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:165994467G>A	ENST00000360093.3	-	15	2804	c.2313C>T	c.(2311-2313)gtC>gtT	p.V771V	SCN3A_ENST00000283254.7_Silent_p.V771V|SCN3A_ENST00000409101.3_Silent_p.V722V	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	771						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	GGGTATTTAAGACAATGCAAA	0.383000													106	103					0	0	0.323286	0	0
ITIH6	347365	broad.mit.edu	37	X	54780086	54780086	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:54780086G>A	ENST00000218436.6	-	11	3379	c.3350C>T	c.(3349-3351)gCa>gTa	p.A1117V		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1117					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										GCTCTTACCTGCCTTTGGGTC	0.493000													21	23					0	0	0.264190	0	0
KIF4B	285643	broad.mit.edu	37	5	154393686	154393686	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:154393686G>T	ENST00000435029.4	+	1	427	c.267G>T	c.(265-267)caG>caT	p.Q89H		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	89	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CCTATGGGCAGACTGGCTCTG	0.463000													71	84					9.13743e-30	1.36051e-29	0.323286	1	0
LRRN3	54674	broad.mit.edu	37	7	110763476	110763476	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:110763476C>A	ENST00000451085.1	+	4	1694	c.648C>A	c.(646-648)agC>agA	p.S216R	LRRN3_ENST00000422987.3_Missense_Mutation_p.S216R|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000405709.2_Intron|IMMP2L_ENST00000452895.1_Intron|IMMP2L_ENST00000447215.1_Intron|LRRN3_ENST00000308478.5_Missense_Mutation_p.S216R|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000331762.3_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	216						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		ATCTTCGCAGCCTGGTTATAG	0.378000													34	121					6.03168e-27	8.73719e-27	0.214465	1	0
LCE2A	353139	broad.mit.edu	37	1	152671415	152671415	+	Missense_Mutation	SNP	C	C	A	rs112496497		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:152671415C>A	ENST00000368779.1	+	2	89	c.38C>A	c.(37-39)cCt>cAt	p.P13H		NM_178428.3	NP_848515.1	Q5TA79	LCE2A_HUMAN	late cornified envelope 2A	13	Cys-rich.				keratinization					breast(1)|large_intestine(1)|liver(2)|lung(4)	8	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCCAGCCCCCTCCCAAGTGC	0.552000													87	161					5.29757e-45	8.75484e-45	0.323286	1	0
IGKV2-30	28919	broad.mit.edu	37	2	89544379	89544379	+	RNA	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:89544379C>T	ENST00000468494.1	-	0	274																											GTCTGGGACCCCAGAGTCCCG	0.498000													35	507					0	0	0.323286	0	0
SATB2	23314	broad.mit.edu	37	2	200137063	200137063	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:200137063G>T	ENST00000443023.1	-	10	3361	c.1896C>A	c.(1894-1896)gaC>gaA	p.D632E	SATB2_ENST00000428695.1_Missense_Mutation_p.D573E|SATB2_ENST00000260926.5_Missense_Mutation_p.D691E|SATB2_ENST00000417098.1_Missense_Mutation_p.D691E|SATB2_ENST00000457245.1_Missense_Mutation_p.D691E			Q9UPW6	SATB2_HUMAN	SATB homeobox 2	691						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(40)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						GCAGCTCCTCGTCCTTATATT	0.557000													126	146					6.66108e-56	1.14863e-55	0.323286	1	0
PTPN14	5784	broad.mit.edu	37	1	214557669	214557669	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:214557669A>C	ENST00000366956.5	-	13	1723	c.1529T>G	c.(1528-1530)cTt>cGt	p.L510R	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	510					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TGGACTGACAAGTTTGTTGCT	0.582000													21	262					0	0	0.234183	0	0
SCAMP4	113178	broad.mit.edu	37	19	1917810	1917810	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:1917810G>T	ENST00000316097.8	+	3	392	c.125G>T	c.(124-126)cGg>cTg	p.R42L	SCAMP4_ENST00000414057.2_3'UTR|SCAMP4_ENST00000409472.1_Missense_Mutation_p.R42L	NM_079834.2	NP_524558.1	Q969E2	SCAM4_HUMAN	secretory carrier membrane protein 4	42					protein transport	integral to membrane							Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGATCTACCGGCTGTGGATG	0.657000													44	6					6.08268e-21	8.24784e-21	0.323286	1	0
MORC3	23515	broad.mit.edu	37	21	37710217	37710217	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:37710217G>T	ENST00000400485.1	+	4	509	c.433G>T	c.(433-435)Gtt>Ttt	p.V145F	MORC3_ENST00000487909.1_3'UTR	NM_015358.2	NP_056173.1	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	145					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	35						GCATGTTGTTGTTCCAATAGT	0.393000													36	54					3.3946e-10	3.8851e-10	0.225048	1	0
DNAJB8	165721	broad.mit.edu	37	3	128181684	128181684	+	Silent	SNP	C	C	A	rs148940950	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:128181684C>A	ENST00000469083.1	-	2	2962	c.405G>T	c.(403-405)tcG>tcT	p.S135S	DNAJB8_ENST00000319153.3_Silent_p.S135S			Q8NHS0	DNJB8_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 8	135					protein folding		heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.177)		CAAAGCCTGCCGAGAAGGCCC	0.592000													15	42					2.48551e-13	3.01158e-13	0.160694	1	0
LMTK2	22853	broad.mit.edu	37	7	97821251	97821251	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:97821251G>T	ENST00000297293.5	+	11	1767	c.1474G>T	c.(1474-1476)Ggc>Tgc	p.G492C		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	492					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					GCGCAGCCGGGGCCACCTGGA	0.567000													15	42					1.75199e-13	2.13031e-13	0.125774	1	0
SPHKAP	80309	broad.mit.edu	37	2	228882762	228882762	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:228882762C>A	ENST00000392056.3	-	7	2854	c.2808G>T	c.(2806-2808)acG>acT	p.T936T	SPHKAP_ENST00000344657.5_Silent_p.T936T	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	936	PKA-RII subunit binding domain (By similarity).					cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGGAGACGACCGTGTCTGCTA	0.473000													70	104					5.44642e-36	8.56656e-36	0.323286	1	0
SUPT6H	6830	broad.mit.edu	37	17	27024728	27024728	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:27024728G>A	ENST00000314616.6	+	31	4583	c.4300G>A	c.(4300-4302)Gac>Aac	p.D1434N	SUPT6H_ENST00000347486.4_Missense_Mutation_p.D1434N	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1434					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					GTATTATCAGGACTGCAGCGG	0.517000													13	154					0	0	0.105934	0	0
AQP6	363	broad.mit.edu	37	12	50367074	50367074	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:50367074T>C	ENST00000315520.5	+	1	455	c.118T>C	c.(118-120)Ttt>Ctt	p.F40L	AQP6_ENST00000551733.1_Intron	NM_001652.3	NP_001643.2	Q13520	AQP6_HUMAN	aquaporin 6, kidney specific	40					excretion|odontogenesis	integral to plasma membrane|transport vesicle membrane	anion channel activity|water channel activity			endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(2)	13						GTATGTGTTCTTTGGCGTGGG	0.612000													75	185					0	0	0.323286	0	0
CNTFR	1271	broad.mit.edu	37	9	34556335	34556335	+	Missense_Mutation	SNP	G	G	A	rs145978650		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:34556335G>A	ENST00000378980.3	-	7	979	c.686C>T	c.(685-687)cCc>cTc	p.P229L	CNTFR_ENST00000351266.4_Missense_Mutation_p.P229L	NM_001207011.1|NM_147164.2	NP_001193940.1|NP_671693.1	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	229	Fibronectin type-III 2.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding	p.P229L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(4)|skin(1)	15	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		CCAGGTCGAGGGGGTCTGCCA	0.612000													35	13					0	0	0.193644	0	0
UBR4	23352	broad.mit.edu	37	1	19442079	19442079	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:19442079C>T	ENST00000375267.2	-	74	10879	c.10876G>A	c.(10876-10878)Gag>Aag	p.E3626K	UBR4_ENST00000375217.2_Missense_Mutation_p.E3619K|UBR4_ENST00000375254.3_Missense_Mutation_p.E3626K|UBR4_ENST00000375226.2_Missense_Mutation_p.E3602K|UBR4_ENST00000375218.3_Missense_Mutation_p.E41K			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3626					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		ATCTTCACCTCTGTCTGTCCA	0.512000													98	202					0	0	0.323286	0	0
FAM90A1	55138	broad.mit.edu	37	12	8374535	8374535	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:8374535C>G	ENST00000538603.1	-	7	1836	c.1278G>C	c.(1276-1278)caG>caC	p.Q426H	FAM90A1_ENST00000307435.6_Missense_Mutation_p.Q426H	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	426							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		CATGAGGGCTCTGAGCGAGGA	0.597000													29	21					0	0	0.153744	0	0
KIAA1614	57710	broad.mit.edu	37	1	180904852	180904852	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:180904852G>T	ENST00000367588.4	+	5	1862	c.1807G>T	c.(1807-1809)Gtg>Ttg	p.V603L	KIAA1614_ENST00000367587.1_Missense_Mutation_p.V224L	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	603										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						CGGAGACACCGTGTGCCCTGC	0.652000													22	53					1.42536e-11	1.67909e-11	0.309145	1	0
GABBR1	2550	broad.mit.edu	37	6	29599210	29599210	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:29599210G>A	ENST00000377034.4	-	3	587	c.252C>T	c.(250-252)aaC>aaT	p.N84N	GABBR1_ENST00000377016.4_Silent_p.N84N|GABBR1_ENST00000376977.3_Silent_p.N84N	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	84	Sushi 1.				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	TCCAGGAGCCGTTGGCCAGGC	0.587000													21	42					0	0	0.246493	0	0
TRIM37	4591	broad.mit.edu	37	17	57128626	57128626	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:57128626C>A	ENST00000376149.3	-	14	1706	c.897G>T	c.(895-897)caG>caT	p.Q299H	TRIM37_ENST00000262294.7_Missense_Mutation_p.Q421H|TRIM37_ENST00000393066.3_Missense_Mutation_p.Q421H|TRIM37_ENST00000393065.2_Missense_Mutation_p.Q387H			O94972	TRI37_HUMAN	tripartite motif containing 37	421	MATH.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CAGCTTCCAACTGAGTAATGT	0.348000									Mulibrey Nanism				20	35					2.21704e-12	2.64592e-12	0.264190	1	0
PIWIL1	9271	broad.mit.edu	37	12	130831604	130831604	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:130831604G>T	ENST00000245255.3	+	6	922	c.650G>T	c.(649-651)aGg>aTg	p.R217M		NM_001190971.1|NM_004764.4	NP_001177900.1|NP_004755.2	Q96J94	PIWL1_HUMAN	piwi-like RNA-mediated gene silencing 1	217					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			breast(6)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(26)|ovary(2)|prostate(4)|skin(3)|urinary_tract(1)	57	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		ATTATTTTCAGGAGGTATGTG	0.333000													63	7					2.79145e-41	4.52151e-41	0.323286	1	0
GALNT18	374378	broad.mit.edu	37	11	11362515	11362515	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:11362515A>T	ENST00000227756.4	-	7	1540	c.1129T>A	c.(1129-1131)Tgc>Agc	p.C377S		NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		ATCCGTGAGCAGGGCAGGACC	0.612000													418	36					0	0	0.323286	0	0
KIF15	56992	broad.mit.edu	37	3	44869002	44869002	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:44869002G>T	ENST00000326047.4	+	23	2987	c.2838G>T	c.(2836-2838)acG>acT	p.T946T	KIF15_ENST00000425755.1_Silent_p.T581T	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	946					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AGAAAGAGACGGCCAAGTGTG	0.348000													37	29					2.40228e-13	2.9153e-13	0.312237	1	0
CLDN16	10686	broad.mit.edu	37	3	190126181	190126181	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:190126181T>C	ENST00000264734.2	+	4	919	c.671T>C	c.(670-672)aTa>aCa	p.I224T	CLDN16_ENST00000456423.1_Intron	NM_006580.3	NP_006571.1	Q9Y5I7	CLD16_HUMAN	claudin 16	224					calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|skin(1)	19	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		TTGCACAATATATTTCTTGGT	0.453000													128	98					0	0	0.323286	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110509228	110509228	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:110509228C>A	ENST00000378402.5	+	64	10512	c.10408C>A	c.(10408-10410)Ctt>Att	p.L3470I		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3470					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CCAAGATGGCCTTCCTGGATG	0.368000										HNSCC(38;0.096)			88	80					1.41191e-52	2.40521e-52	0.323286	1	0
SUPV3L1	6832	broad.mit.edu	37	10	70958934	70958934	+	Missense_Mutation	SNP	A	A	T	rs148715762		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:70958934A>T	ENST00000359655.4	+	10	1339	c.1279A>T	c.(1279-1281)Att>Ttt	p.I427F		NM_003171.3	NP_003162.2	Q8IYB8	SUV3_HUMAN	suppressor of var1, 3-like 1 (S. cerevisiae)	427	Helicase C-terminal.				DNA duplex unwinding	mitochondrial nucleoid|nucleus	ATP binding|DNA binding|DNA helicase activity|RNA binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TACAGATGCAATTGGCATGGG	0.308000													21	30					0	0	0.234183	0	0
HMCN1	83872	broad.mit.edu	37	1	185931768	185931768	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:185931768T>C	ENST00000271588.4	+	12	2176	c.1947T>C	c.(1945-1947)gaT>gaC	p.D649D	HMCN1_ENST00000485744.1_3'UTR|HMCN1_ENST00000367492.2_Silent_p.D649D	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	649	Ig-like C2-type 3.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCGTTAACGATATGTTTATCG	0.413000													127	237					0	0	0.323286	0	0
FAM194B	220081	broad.mit.edu	37	13	46170559	46170559	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:46170559C>T	ENST00000298738.2	-	3	746	c.582G>A	c.(580-582)ctG>ctA	p.L194L		NM_182542.2	NP_872348.2	Q5W0A0	F194B_HUMAN	family with sequence similarity 194, member B	194	Glu-rich.									breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)	5						CTTCCTTCTCCAGAGCTTCTT	0.438000													33	45					0	0	0.163468	0	0
SIAE	54414	broad.mit.edu	37	11	124524637	124524637	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:124524637C>T	ENST00000263593.3	-	4	630	c.458G>A	c.(457-459)cGc>cAc	p.R153H	SIAE_ENST00000545756.1_Missense_Mutation_p.R118H			Q9HAT2	SIAE_HUMAN	sialic acid acetylesterase	153						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(2)	15	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		AGAGAGGATGCGGACAGACTG	0.483000													5	743					0	0	0.217242	0	0
NEU3	10825	broad.mit.edu	37	11	74717042	74717042	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:74717042G>T	ENST00000294064.4	+	3	1818	c.891G>T	c.(889-891)caG>caT	p.Q297H	NEU3_ENST00000529024.1_Intron|NEU3_ENST00000532963.1_3'UTR|NEU3_ENST00000545272.1_Missense_Mutation_p.Q188H|NEU3_ENST00000544263.1_Missense_Mutation_p.Q264H|NEU3_ENST00000531509.1_Missense_Mutation_p.Q297H	NM_006656.5	NP_006647.3	A8K327	A8K327_HUMAN	sialidase 3 (membrane sialidase)	297										kidney(2)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	11						AAGGCTTTCAGAGACTGGCCC	0.607000													44	93					5.57489e-27	8.08307e-27	0.323286	1	0
BACH2	60468	broad.mit.edu	37	6	90661200	90661200	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:90661200C>A	ENST00000257749.4	-	7	1332	c.625G>T	c.(625-627)Gag>Tag	p.E209*	BACH2_ENST00000343122.3_Nonsense_Mutation_p.E209*|BACH2_ENST00000537989.1_Nonsense_Mutation_p.E209*|RP3-512E2.2_ENST00000413986.1_RNA|RP3-512E2.2_ENST00000445838.1_RNA	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	209						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		ACGTCAGGCTCGGGCAGCAGG	0.572000													54	98					1.27334e-21	1.73953e-21	0.323286	1	0
ANKK1	255239	broad.mit.edu	37	11	113270007	113270007	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:113270007G>A	ENST00000303941.3	+	8	1410	c.1316G>A	c.(1315-1317)gGg>gAg	p.G439E		NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	439							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|stomach(1)	29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		GCCCAGAATGGGGATGACGGC	0.622000													12	5					0	0	0.080935	0	0
SPATA22	84690	broad.mit.edu	37	17	3343456	3343456	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:3343456C>T	ENST00000573128.1	-	9	1560	c.1077G>A	c.(1075-1077)gtG>gtA	p.V359V	SPATA22_ENST00000355380.4_Silent_p.V316V|SPATA22_ENST00000541913.1_Silent_p.V343V|SPATA22_ENST00000572969.1_Silent_p.V359V|SPATA22_ENST00000575375.1_Silent_p.V359V|SPATA22_ENST00000397168.3_Silent_p.V359V			Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	359										breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|skin(2)	19						TTTCATTCATCACATTAATAT	0.323000													33	57					0	0	0.183431	0	0
OR10G7	390265	broad.mit.edu	37	11	123909484	123909484	+	Silent	SNP	C	C	A	rs138227924		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:123909484C>A	ENST00000330487.5	-	1	233	c.225G>T	c.(223-225)acG>acT	p.T75T		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TTTTGGGCACCGTGACAGTGG	0.537000													50	329					7.05995e-25	1.00067e-24	0.323286	1	0
GPR32	2854	broad.mit.edu	37	19	51274757	51274757	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:51274757T>A	ENST00000270590.4	+	1	1037	c.900T>A	c.(898-900)gcT>gcA	p.A300A		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	300						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TCCTCCAGGCTAGCTTTGCCT	0.527000													22	54					0	0	0.249174	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128773	126128773	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:126128773A>T	ENST00000299308.3	+	6	1582	c.1574A>T	c.(1573-1575)gAc>gTc	p.D525V	TMEM132B_ENST00000535886.1_Missense_Mutation_p.D37V	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	525						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAGATCTCAGACACCGAGCTG	0.562000													39	52					0	0	0.214465	0	0
ARPP21	10777	broad.mit.edu	37	3	35748563	35748563	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:35748563G>C	ENST00000187397.4	+	10	1240	c.784G>C	c.(784-786)Gaa>Caa	p.E262Q	ARPP21_ENST00000444190.1_Missense_Mutation_p.E262Q|ARPP21_ENST00000417925.1_Missense_Mutation_p.E262Q|ARPP21_ENST00000458225.1_Missense_Mutation_p.E262Q|ARPP21_ENST00000337271.5_Missense_Mutation_p.E262Q	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	262						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						TATTGATAAAGAAGACAATCA	0.418000													53	96					0	0	0.323286	0	0
KCNH5	27133	broad.mit.edu	37	14	63416862	63416862	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:63416862A>T	ENST00000322893.7	-	7	1626	c.1358T>A	c.(1357-1359)aTg>aAg	p.M453K	KCNH5_ENST00000420622.2_Missense_Mutation_p.M453K|KCNH5_ENST00000394964.2_Missense_Mutation_p.M395K|KCNH5_ENST00000394968.1_Missense_Mutation_p.M395K	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	453					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GCCAACCATCATCATAGCCAC	0.373000													62	207					0	0	0.323286	0	0
SP140	11262	broad.mit.edu	37	2	231103043	231103043	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:231103043T>A	ENST00000392045.3	+	3	467	c.353T>A	c.(352-354)aTt>aAt	p.I118N	SP140_ENST00000373645.3_Missense_Mutation_p.I118N|SP140_ENST00000544128.1_3'UTR|SP140_ENST00000417495.3_Missense_Mutation_p.I118N|SP140_ENST00000420434.3_Missense_Mutation_p.I118N|SP140_ENST00000343805.6_Missense_Mutation_p.I118N|SP140_ENST00000350136.5_Missense_Mutation_p.I98N|SP140_ENST00000486687.2_Missense_Mutation_p.I118N	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	118	HSR.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TTCAGCAGGATTAACCTGATG	0.428000													19	161					0	0	0.249174	0	0
KRT1	3848	broad.mit.edu	37	12	53070112	53070112	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:53070112G>T	ENST00000252244.3	-	7	1480	c.1422C>A	c.(1420-1422)gcC>gcA	p.A474A		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	474	Coil 2.|Rod.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						CCAGATCCAGGGCCAGCTTTG	0.582000													26	85					1.96642e-18	2.56854e-18	0.246493	1	0
OR13C2	392376	broad.mit.edu	37	9	107367580	107367580	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:107367580G>T	ENST00000542196.1	-	1	371	c.329C>A	c.(328-330)aCa>aAa	p.T110K		NM_001004481.1	NP_001004481.1	Q8NGS9	O13C2_HUMAN	olfactory receptor, family 13, subfamily C, member 2	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CACACACTCTGTTGTCCCCAT	0.507000													167	26					2.49858e-89	4.52256e-89	0.323286	1	0
AGPAT9	84803	broad.mit.edu	37	4	84457904	84457904	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:84457904G>C	ENST00000395226.2	+	2	347	c.129G>C	c.(127-129)gtG>gtC	p.V43V	AGPAT9_ENST00000264409.4_Silent_p.V43V	NM_001256421.1	NP_001243350.1	Q53EU6	GPAT3_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 9	43					phospholipid biosynthetic process|regulation of TOR signaling cascade|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	glycerol-3-phosphate O-acyltransferase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(3)	13		Hepatocellular(203;0.114)				AGATCCTAGTGAAAACTTTAG	0.577000													10	7					0	0	0.080935	0	0
OR4K17	390436	broad.mit.edu	37	14	20585586	20585586	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20585586C>T	ENST00000315543.4	+	1	21	c.21C>T	c.(19-21)ctC>ctT	p.L7L		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		ATTTTTCACTCATACTCCATG	0.363000													14	189					0	0	0.132662	0	0
CNOT2	4848	broad.mit.edu	37	12	70723271	70723271	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:70723271G>A	ENST00000229195.3	+	5	886	c.307G>A	c.(307-309)Ggc>Agc	p.G103S	CNOT2_ENST00000548230.1_3'UTR|CNOT2_ENST00000418359.3_Missense_Mutation_p.G103S	NM_014515.5	NP_055330.1	Q9NZN8	CNOT2_HUMAN	CCR4-NOT transcription complex, subunit 2	103					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	protein binding|RNA polymerase II transcription cofactor activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(2)|urinary_tract(1)	20	Renal(347;0.236)		GBM - Glioblastoma multiforme(1;4.77e-09)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00243)|STAD - Stomach adenocarcinoma(21;0.0118)			CTTATCACAAGGCACTCAGTT	0.458000													150	248					0	0	0.323286	0	0
MOCS3	27304	broad.mit.edu	37	20	49576693	49576693	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:49576693A>G	ENST00000244051.1	+	1	1331	c.1314A>G	c.(1312-1314)acA>acG	p.T438T		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	438	Rhodanese.				enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						ACCCTTTAACAGTTCGGGATG	0.478000													32	109					0	0	0.163468	0	0
SAMD9L	219285	broad.mit.edu	37	7	92765029	92765029	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:92765029C>A	ENST00000318238.4	-	5	1472	c.256G>T	c.(256-258)Gat>Tat	p.D86Y	SAMD9L_ENST00000437805.1_Missense_Mutation_p.D86Y|SAMD9L_ENST00000411955.1_Missense_Mutation_p.D86Y	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	86								p.D86Y(1)		central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			TGTCCCGGATCATGATTGTCA	0.373000													129	207					1.3892e-51	2.36005e-51	0.323286	1	0
PAPPA2	60676	broad.mit.edu	37	1	176769233	176769233	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:176769233G>T	ENST00000367662.3	+	21	6331	c.5167G>T	c.(5167-5169)Gac>Tac	p.D1723Y		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1723	Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.D1723Y(1)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						ATGGCACCCAGACCCCGTCTT	0.483000													190	87					5.94801e-108	1.09064e-107	0.323286	1	0
CHEK2P2	646096	broad.mit.edu	37	15	20490534	20490534	+	RNA	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:20490534T>G	ENST00000555186.1	+	0	514					NR_038836.1																						TTGTTGGTAGTGGATCCAAAG	0.428000													50	488					0	0	0.323286	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43630541	43630541	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:43630541G>A	ENST00000332857.6	-	1	189	c.161C>T	c.(160-162)cCa>cTa	p.P54L		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		TGGTGAGGGTGGGTCATCACA	0.473000													215	304					0	0	0.323286	0	0
MAEL	84944	broad.mit.edu	37	1	166974517	166974517	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:166974517T>G	ENST00000367872.4	+	8	972	c.728T>G	c.(727-729)cTc>cGc	p.L243R	MAEL_ENST00000367870.2_Missense_Mutation_p.L212R|MAEL_ENST00000491055.1_3'UTR	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	243					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						CTACAACTTCTCACTGTAGAG	0.388000													29	86					0	0	0.144211	0	0
CBLB	868	broad.mit.edu	37	3	105422977	105422977	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:105422977G>C	ENST00000264122.4	-	11	1769	c.1448C>G	c.(1447-1449)tCc>tGc	p.S483C	CBLB_ENST00000394027.3_Missense_Mutation_p.S505C|CBLB_ENST00000405772.1_Missense_Mutation_p.S483C|CBLB_ENST00000403724.1_Missense_Mutation_p.S483C	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	483	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						AAGGGGAGAGGATCCTGGTGA	0.517000			Mis S		AML								34	265					0	0	0.225048	0	0
TG	7038	broad.mit.edu	37	8	133899126	133899126	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:133899126A>T	ENST00000220616.4	+	9	1549	c.1509A>T	c.(1507-1509)caA>caT	p.Q503H	TG_ENST00000377869.1_Missense_Mutation_p.Q503H	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	503					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TTTTCCAGCAACTTGGTCTTG	0.443000													56	71					0	0	0.323286	0	0
RPS6KB2	6199	broad.mit.edu	37	11	67200238	67200238	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:67200238G>T	ENST00000312629.5	+	7	591	c.546G>T	c.(544-546)ctG>ctT	p.L182L	AP003419.16_ENST00000535922.1_RNA|RPS6KB2_ENST00000524814.1_3'UTR|RPS6KB2_ENST00000539188.1_3'UTR	NM_003952.2	NP_003943.2	Q9UBS0	KS6B2_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 2	182	Protein kinase.				nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of translational initiation|translation	nucleoplasm	ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(3)|salivary_gland(1)|stomach(2)	25			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			CGCTGGCCCTGGGCCATCTCC	0.617000													29	44					4.62619e-21	6.28115e-21	0.203993	1	0
STATH	6779	broad.mit.edu	37	4	70865520	70865520	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:70865520A>G	ENST00000246895.4	+	4	207	c.96A>G	c.(94-96)agA>agG	p.R32R	STATH_ENST00000381060.2_Intron	NM_003154.2	NP_003145.1	P02808	STAT_HUMAN	statherin	32			Missing (in statherin variants SV2 and SV3).		biomineral tissue development|negative regulation of bone mineralization|ossification|saliva secretion	extracellular region	extracellular matrix constituent, lubricant activity|hydroxyapatite binding|protein binding|structural constituent of tooth enamel			lung(2)|skin(1)	3						GAATTGGAAGATTCGGTGTAA	0.303000													26	8					0	0	0.116897	0	0
ACTA1	58	broad.mit.edu	37	1	229567625	229567625	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:229567625T>C	ENST00000366684.3	-	6	935	c.833A>G	c.(832-834)gAg>gGg	p.E278G	ACTA1_ENST00000366683.2_Missense_Mutation_p.E190G	NM_001100.3	NP_001091.1	P68133	ACTS_HUMAN	actin, alpha 1, skeletal muscle	278					muscle filament sliding|skeletal muscle fiber development|skeletal muscle thin filament assembly	actin filament|cytosol|stress fiber|striated muscle thin filament	ADP binding|ATP binding|myosin binding|structural constituent of cytoskeleton			endometrium(4)|large_intestine(4)|lung(18)|prostate(1)|urinary_tract(1)	28	Breast(184;0.0858)|Ovarian(103;0.103)	Prostate(94;0.167)			Dornase Alfa(DB00003)	GTAGGTGGTCTCGTGAATGCC	0.667000													22	110					0	0	0.153744	0	0
SRGAP3	9901	broad.mit.edu	37	3	9106199	9106199	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:9106199C>A	ENST00000383836.3	-	5	980	c.553G>T	c.(553-555)Gag>Tag	p.E185*	SRGAP3_ENST00000433332.3_5'UTR|SRGAP3_ENST00000360413.3_Nonsense_Mutation_p.E185*	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	185					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TCCTGCTTCTCAGCCTCCTTC	0.557000			T	RAF1	pilocytic astrocytoma								38	95					5.20837e-25	7.39923e-25	0.268233	1	0
IFT122	55764	broad.mit.edu	37	3	129233292	129233292	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:129233292G>T	ENST00000296266.3	+	26	3393	c.3201G>T	c.(3199-3201)cgG>cgT	p.R1067R	IFT122_ENST00000507564.1_Silent_p.R1009R|IFT122_ENST00000504021.1_Silent_p.R893R|IFT122_ENST00000349441.2_Silent_p.R906R|IFT122_ENST00000431818.2_Silent_p.R866R|IFT122_ENST00000347300.2_Silent_p.R957R|IFT122_ENST00000348417.2_Silent_p.R1016R|IFT122_ENST00000440957.2_Silent_p.R807R	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	1016					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						GGCTGGCCCGGCACGCCTATG	0.592000													40	29					3.09758e-43	5.08115e-43	0.323286	1	0
PLCL1	5334	broad.mit.edu	37	2	198950124	198950124	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:198950124C>A	ENST00000428675.1	+	2	2281	c.1883C>A	c.(1882-1884)cCa>cAa	p.P628Q	PLCL1_ENST00000437704.2_Missense_Mutation_p.P530Q	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	628	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	AATGAGTACCCAGAGGATTTT	0.368000													42	68					1.89013e-27	2.74952e-27	0.323286	1	0
ENDOD1	23052	broad.mit.edu	37	11	94862456	94862456	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:94862456G>T	ENST00000278505.4	+	2	1334	c.1216G>T	c.(1216-1218)Gcc>Tcc	p.A406S		NM_015036.2	NP_055851.1	O94919	ENDD1_HUMAN	endonuclease domain containing 1	406						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				CAAGGTCGTGGCCAAAGTCAT	0.552000													55	101					2.43698e-19	3.2288e-19	0.323286	1	0
MEP1A	4224	broad.mit.edu	37	6	46802995	46802995	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:46802995A>G	ENST00000230588.4	+	13	1802	c.1793A>G	c.(1792-1794)cAc>cGc	p.H598R		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	598					digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			GATATCACCCACCTCAGCCAG	0.502000													6	19					0	0	0.278610	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23815429	23815429	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:23815429A>G	ENST00000264867.2	-	8	1796	c.1677T>C	c.(1675-1677)tcT>tcC	p.S559S	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	559					androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GGGGTCTTTGAGAAAATAAGG	0.453000													34	56					0	0	0.214465	0	0
CMTM5	116173	broad.mit.edu	37	14	23847948	23847948	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:23847948C>A	ENST00000339180.4	+	3	566	c.350C>A	c.(349-351)cCc>cAc	p.P117H	CMTM5_ENST00000555731.1_Intron|CMTM5_ENST00000382809.2_Intron|CMTM5_ENST00000397227.3_Intron|CMTM5_ENST00000359320.3_Intron|CMTM5_ENST00000342473.4_Intron			Q96DZ9	CKLF5_HUMAN	CKLF-like MARVEL transmembrane domain containing 5	117	MARVEL.				chemotaxis	extracellular space|integral to membrane	cytokine activity			endometrium(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	8	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.0064)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0382)		AAGGTCCAGCCCCAGCCCTGG	0.637000													17	25					1.96292e-10	2.25656e-10	0.219247	1	0
NXPH2	11249	broad.mit.edu	37	2	139428571	139428571	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:139428571C>A	ENST00000272641.3	-	2	822	c.716G>T	c.(715-717)aGt>aTt	p.S239I		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	239	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		ATAATCAACACTGTAAAAGGC	0.458000													66	191					1.34159e-35	2.10482e-35	0.323286	1	0
RAI14	26064	broad.mit.edu	37	5	34796101	34796101	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:34796101T>A	ENST00000265109.3	+	4	512	c.225T>A	c.(223-225)caT>caA	p.H75Q	RAI14_ENST00000397449.1_Missense_Mutation_p.H68Q|RAI14_ENST00000507276.1_3'UTR|RAI14_ENST00000512629.1_Missense_Mutation_p.H75Q|RAI14_ENST00000428746.2_Missense_Mutation_p.H75Q|RAI14_ENST00000503673.1_Missense_Mutation_p.H75Q|RAI14_ENST00000515799.1_Missense_Mutation_p.H78Q|RAI14_ENST00000506376.1_Missense_Mutation_p.H67Q	NM_001145522.1|NM_015577.2	NP_001138994.1|NP_056392.2	Q9P0K7	RAI14_HUMAN	retinoic acid induced 14	75						cell cortex|cytoskeleton	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(19)|lung(22)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(31;0.000191)					TGATTACACATGGTGTGGATG	0.423000													180	167					0	0	0.323286	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18706942	18706942	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:18706942A>G	ENST00000380548.4	+	14	2111	c.1772A>G	c.(1771-1773)aAc>aGc	p.N591S	ADAMTSL1_ENST00000276935.6_Missense_Mutation_p.N591S	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	591						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CCTGAGTTCAACCCAGACGAG	0.577000													45	196					0	0	0.323286	0	0
BNC2	54796	broad.mit.edu	37	9	16436590	16436590	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:16436590A>T	ENST00000380672.4	-	6	1659	c.1602T>A	c.(1600-1602)ccT>ccA	p.P534P	BNC2_ENST00000380666.2_Silent_p.P534P|BNC2_ENST00000545497.1_Silent_p.P439P|BNC2_ENST00000380667.2_Silent_p.P467P	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	534	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		GGGGTCGGCCAGGGCTTGTGA	0.493000													42	195					0	0	0.301197	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113661503	113661503	+	RNA	SNP	C	C	A	rs148573093	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:113661503C>A	ENST00000393544.2	+	0	1551																											ACCAGGTTGCCCCCTTCACCT	0.542000													143	72					1.00589e-60	1.76502e-60	0.323286	1	0
TRBV27	28560	broad.mit.edu	37	7	142423625	142423625	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142423625C>A	ENST00000506718.1	+	0	633				TRBV27_ENST00000390399.3_RNA																							AGGAATTTCCCCCTGATCCTG	0.493000													194	193					2.92535e-82	5.26733e-82	0.323286	1	0
NAT10	55226	broad.mit.edu	37	11	34149018	34149018	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:34149018T>C	ENST00000257829.3	+	12	1322	c.1116T>C	c.(1114-1116)caT>caC	p.H372H	NAT10_ENST00000531159.2_Silent_p.H300H|NAT10_ENST00000527971.1_Intron	NM_024662.2	NP_078938.2	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	372						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				AGTATATACATCCTGCAGATG	0.478000													30	435					0	0	0.134883	0	0
CCDC105	126402	broad.mit.edu	37	19	15131385	15131385	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:15131385C>A	ENST00000292574.3	+	3	870	c.788C>A	c.(787-789)tCa>tAa	p.S263*		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	263					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						AGACGCCACTCATGGGTGAAC	0.602000													53	2					1.77791e-30	2.66902e-30	0.323286	1	0
TTN	7273	broad.mit.edu	37	2	179537183	179537183	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179537183T>A	ENST00000589042.1	-	154	35105	c.34881A>T	c.(34879-34881)ccA>ccT	p.P11627P	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Silent_p.P11253P|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Silent_p.P10326P|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11461	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTCTTTTCTGGGACTTTCT	0.368000													241	250					0	0	0.323286	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202391820	202391820	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:202391820A>G	ENST00000406302.3	+	3	648	c.495A>G	c.(493-495)gaA>gaG	p.E165E	PPP1R12B_ENST00000356764.2_Silent_p.E165E|PPP1R12B_ENST00000480184.1_Silent_p.E165E|PPP1R12B_ENST00000336894.4_Silent_p.E165E	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B	165					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			ACCTTGCAGAAGAGCCAGCCA	0.453000													21	103					0	0	0.116897	0	0
SLC6A13	6540	broad.mit.edu	37	12	333264	333264	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:333264A>T	ENST00000343164.4	-	11	1257	c.1205T>A	c.(1204-1206)cTg>cAg	p.L402Q	SLC6A13_ENST00000539668.1_5'UTR|SLC6A13_ENST00000445055.2_Missense_Mutation_p.L310Q	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	402					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CATGTCCACCAGCGCTGTCAC	0.562000													19	92					0	0	0.264190	0	0
FLRT2	23768	broad.mit.edu	37	14	86088361	86088361	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:86088361A>G	ENST00000330753.4	+	2	1270	c.503A>G	c.(502-504)aAg>aGg	p.K168R	FLRT2_ENST00000554746.1_Missense_Mutation_p.K168R	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	168					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TTTTTGTCTAAGAATCACCTG	0.507000													9	109					0	0	0.069234	0	0
LINC01410	103352539	broad.mit.edu	37	9	66468782	66468782	+	RNA	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:66468782C>T	ENST00000424345.1	+	0	2349																											acctggagtgctcacaacgtg	0.483000													3	17					0	0	0.115264	0	0
TENM4	26011	broad.mit.edu	37	11	78780983	78780983	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:78780983C>A	ENST00000278550.7	-	5	469	c.7G>T	c.(7-9)Gtg>Ttg	p.V3L	TENM4_ENST00000533038.1_5'UTR	NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CTCTCCTTCACGTCCATGGCC	0.682000													3	3					6.4e-05	6.75935e-05	0.115264	1	0
OVCH2	341277	broad.mit.edu	37	11	7721932	7721932	+	RNA	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:7721932T>G	ENST00000454689.1	-	0	811				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		CCTCACATTGTTTCTCCAGCC	0.512000													16	71					0	0	0.132662	0	0
SLIT2	9353	broad.mit.edu	37	4	20543082	20543082	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:20543082C>T	ENST00000504154.1	+	20	2235	c.1983C>T	c.(1981-1983)ctC>ctT	p.L661L	SLIT2_ENST00000273739.5_Silent_p.L665L|SLIT2_ENST00000503823.1_Silent_p.L653L|SLIT2_ENST00000503837.1_Silent_p.L657L	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	661					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TTAGAAACCTCTTGGCCAATC	0.473000													16	43					0	0	0.175082	0	0
DPCD	25911	broad.mit.edu	37	10	103348126	103348126	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:103348126G>T	ENST00000416979.2	+	4	971	c.543G>T	c.(541-543)cgG>cgT	p.R181R	DPCD_ENST00000470165.1_Intron|DPCD_ENST00000370148.2_Silent_p.R11R|DPCD_ENST00000370151.4_Silent_p.R11R|DPCD_ENST00000370147.1_Silent_p.R11R			Q9BVM2	DPCD_HUMAN	deleted in primary ciliary dyskinesia homolog (mouse)	11							protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(1)	5						AGAGTCTGCGGACAGCCCAGA	0.652000													7	0					0.00307968	0.00316764	0.278610	1	0
ZNF652	22834	broad.mit.edu	37	17	47390085	47390085	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:47390085C>A	ENST00000362063.2	-	3	1341	c.1023G>T	c.(1021-1023)atG>atT	p.M341I	ZNF652_ENST00000430262.2_Missense_Mutation_p.M341I	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			GCACATGAGCCATGGTATAGA	0.388000													30	95					8.88839e-20	1.18295e-19	0.153744	1	0
SPOCK2	9806	broad.mit.edu	37	10	73830120	73830120	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:73830120C>A	ENST00000373109.2	-	5	868	c.424G>T	c.(424-426)Gcc>Tcc	p.A142S	SPOCK2_ENST00000536168.1_Missense_Mutation_p.A142S|SPOCK2_ENST00000317376.4_Missense_Mutation_p.A142S	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	142	Kazal-like.				extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						GCAAGCTGGGCCATGTGGCAG	0.617000													5	11					2.0095e-06	2.16919e-06	0.248553	1	0
PRPF4B	8899	broad.mit.edu	37	6	4056595	4056595	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:4056595G>T	ENST00000337659.6	+	12	2607	c.2507G>T	c.(2506-2508)gGg>gTg	p.G836V	PRPF4B_ENST00000538861.1_Missense_Mutation_p.G822V	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	836	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TGCGATTTTGGGTCGGCTTCA	0.323000													21	80					2.59497e-14	3.20951e-14	0.257332	1	0
LPA	4018	broad.mit.edu	37	6	161027647	161027647	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:161027647C>A	ENST00000447678.1	-	18	2767	c.2647G>T	c.(2647-2649)Gcc>Tcc	p.A883S	LPA_ENST00000316300.5_Missense_Mutation_p.A883S	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3391	Kringle 8.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	CAATAAGGGGCTGCCACAGGA	0.527000													132	241					3.29933e-67	5.84555e-67	0.323286	1	0
DUSP27	92235	broad.mit.edu	37	1	167097596	167097596	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:167097596G>T	ENST00000361200.2	+	6	3394	c.3228G>T	c.(3226-3228)aaG>aaT	p.K1076N	DUSP27_ENST00000443333.1_Missense_Mutation_p.K1076N|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.K1076N			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1076					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AGTCATCCAAGTCAGACTTCT	0.522000													53	33					9.53978e-28	1.39296e-27	0.323286	1	0
ELAVL4	1996	broad.mit.edu	37	1	50610781	50610781	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:50610781C>A	ENST00000371824.1	+	2	419	c.162C>A	c.(160-162)ccC>ccA	p.P54P	ELAVL4_ENST00000371827.1_Silent_p.P54P|ELAVL4_ENST00000448907.2_Silent_p.P57P|ELAVL4_ENST00000357083.4_Silent_p.P71P|ELAVL4_ENST00000371819.1_Silent_p.P59P|ELAVL4_ENST00000371821.1_Silent_p.P59P|ELAVL4_ENST00000371823.4_Silent_p.P54P|ELAVL4_ENST00000492299.1_3'UTR			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	54	RRM 1.				mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						ACTATTTACCCCAGAATATGA	0.458000													119	239					5.49952e-60	9.63349e-60	0.323286	1	0
TMTC4	84899	broad.mit.edu	37	13	101321050	101321050	+	Splice_Site	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:101321050T>C	ENST00000342624.5	-	3	262		c.e3-2		TMTC4_ENST00000328767.5_Splice_Site|TMTC4_ENST00000376234.3_Splice_Site	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4							integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTTAGGAATCTGCAGGAAAAA	0.448000													29	95					0	0	0.125774	0	0
CNDP1	84735	broad.mit.edu	37	18	72226588	72226588	+	Missense_Mutation	SNP	G	G	T	rs142534952		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:72226588G>T	ENST00000582365.1	+	2	121	c.55G>T	c.(55-57)Gac>Tac	p.D19Y	CNDP1_ENST00000358821.3_Missense_Mutation_p.D62Y|CNDP1_ENST00000585136.1_3'UTR			Q96KN2	CNDP1_HUMAN	carnosine dipeptidase 1 (metallopeptidase M20 family)	62					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		CATCGAGAGCGACTCTGTCCA	0.637000													13	49					1.3612e-06	1.47349e-06	0.132662	1	0
ELMO2	63916	broad.mit.edu	37	20	45003281	45003281	+	Splice_Site	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:45003281T>C	ENST00000372176.1	-	14	1270		c.e14-2		ELMO2_ENST00000454865.2_Splice_Site|ELMO2_ENST00000290246.6_Splice_Site|ELMO2_ENST00000439931.2_Splice_Site|ELMO2_ENST00000445496.2_Splice_Site|ELMO2_ENST00000396391.1_Splice_Site|ELMO2_ENST00000352077.2_Splice_Site|ELMO2_ENST00000488853.1_Splice_Site			Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2						apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				GATGTGGTTCTAGAGAAATAA	0.527000													51	143					0	0	0.323286	0	0
SPTBN4	57731	broad.mit.edu	37	19	41040047	41040047	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:41040047G>T	ENST00000352632.3	+	20	4242	c.4156G>T	c.(4156-4158)Ggc>Tgc	p.G1386C	SPTBN4_ENST00000392023.1_Missense_Mutation_p.G62C|SPTBN4_ENST00000595535.1_Missense_Mutation_p.G1386C|SPTBN4_ENST00000392025.1_Missense_Mutation_p.G129C|SPTBN4_ENST00000598249.1_Missense_Mutation_p.G1386C|SPTBN4_ENST00000338932.3_Missense_Mutation_p.G1386C			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1386					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAAGAAGCTGGGCGAGATCCG	0.637000													14	9					0.000566183	0.000589996	0.160694	1	0
ARMCX5	64860	broad.mit.edu	37	X	101858468	101858468	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:101858468A>G	ENST00000604957.1	+	1	4021	c.1399A>G	c.(1399-1401)Aga>Gga	p.R467G	ARMCX5_ENST00000537008.1_Missense_Mutation_p.R467G|ARMCX5_ENST00000372742.1_Missense_Mutation_p.R467G|RP4-769N13.7_ENST00000602441.1_RNA|ARMCX5_ENST00000536530.1_Missense_Mutation_p.R467G|ARMCX5_ENST00000541409.1_Missense_Mutation_p.R467G|RP4-769N13.6_ENST00000476910.1_RNA|ARMCX5_ENST00000246174.2_Missense_Mutation_p.R467G	NM_001168478.1	NP_001161950.1	Q6P1M9	ARMX5_HUMAN	armadillo repeat containing, X-linked 5	467							binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	22						CGCCAATACAAGAGAATTGAT	0.328000													74	11					0	0	0.323286	0	0
TRIM50	135892	broad.mit.edu	37	7	72730668	72730668	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:72730668C>A	ENST00000333149.2	-	6	970	c.770G>T	c.(769-771)cGg>cTg	p.R257L	TRIM50_ENST00000453152.1_Missense_Mutation_p.R257L	NM_178125.2	NP_835226.1	Q86XT4	TRI50_HUMAN	tripartite motif containing 50	257						cytoplasm|intracellular membrane-bounded organelle	ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|skin(2)	20						TTCTAAGGGCCGGGCCTGCGG	0.572000													39	81					2.43468e-25	3.47635e-25	0.323286	1	0
OR4N2	390429	broad.mit.edu	37	14	20295925	20295925	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20295925C>T	ENST00000568211.1	+	1	318	c.318C>T	c.(316-318)ttC>ttT	p.F106F	OR4N2_ENST00000315947.1_Silent_p.F106F			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	106					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTGCACTTCCTTGGAGGAG	0.517000													105	673					0	0	0.323286	0	0
RAB30	27314	broad.mit.edu	37	11	82693360	82693360	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:82693360G>T	ENST00000534141.1	-	5	695	c.455C>A	c.(454-456)cCa>cAa	p.P152Q	RAB30_ENST00000533486.1_Silent_p.A153A|RAB30_ENST00000260056.2_Silent_p.A153A|RAB30_ENST00000527633.1_Silent_p.A153A|RP11-659G9.3_ENST00000527550.1_RNA			Q15771	RAB30_HUMAN	RAB30, member RAS oncogene family	0					protein transport|small GTPase mediated signal transduction	Golgi stack|plasma membrane	GTP binding|GTPase activity			endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	13						CAGATTCCTTGGCTGAGGTCT	0.468000													27	91					5.61819e-17	7.20179e-17	0.324025	1	0
SUOX	6821	broad.mit.edu	37	12	56398063	56398063	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:56398063G>T	ENST00000394109.3	+	3	1614	c.890G>T	c.(889-891)cGg>cTg	p.R297L	SUOX_ENST00000548274.1_Missense_Mutation_p.R297L|SUOX_ENST00000394115.2_Missense_Mutation_p.R297L|SUOX_ENST00000551841.2_3'UTR|SUOX_ENST00000356124.4_Missense_Mutation_p.R297L|SUOX_ENST00000266971.3_Missense_Mutation_p.R297L			P51687	SUOX_HUMAN	sulfite oxidase	297	Molybdenum-pterin domain (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)	15			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			GCTGGGGCACGGCTCTGTGAT	0.577000													17	41					5.03518e-11	5.88008e-11	0.189662	1	0
FAM208B	54906	broad.mit.edu	37	10	5788150	5788150	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:5788150G>T	ENST00000328090.5	+	15	3391	c.2766G>T	c.(2764-2766)ggG>ggT	p.G922G		NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	922																	AGGTAACTGGGGAAGAAGCTA	0.323000													38	128					4.53413e-08	5.01686e-08	0.312237	1	0
HERC2P3	283755	broad.mit.edu	37	15	20588507	20588507	+	RNA	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:20588507A>C	ENST00000428453.1	-	0	4243																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CCTAGGGAAAACCTGAGCAAC	0.493000													29	46					0	0	0.116897	0	0
ZFHX4	79776	broad.mit.edu	37	8	77619997	77619997	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:77619997G>A	ENST00000521891.2	+	3	3255	c.2807G>A	c.(2806-2808)aGg>aAg	p.R936K	ZFHX4_ENST00000518282.1_Missense_Mutation_p.R910K|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000050961.6_Missense_Mutation_p.R910K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.R910K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	910						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GAGGAATGGAGGGCAGTAATT	0.488000										HNSCC(33;0.089)			41	54					0	0	0.225048	0	0
USP37	57695	broad.mit.edu	37	2	219320359	219320359	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:219320359C>A	ENST00000258399.3	-	25	3208	c.2796G>T	c.(2794-2796)gaG>gaT	p.E932D	USP37_ENST00000454775.1_Missense_Mutation_p.E932D|USP37_ENST00000418019.1_Missense_Mutation_p.E932D|USP37_ENST00000415516.1_Missense_Mutation_p.E838D	NM_020935.2	NP_065986.2	Q86T82	UBP37_HUMAN	ubiquitin specific peptidase 37	932					ubiquitin-dependent protein catabolic process	nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(2)|breast(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(5)|stomach(1)	35		Renal(207;0.0915)		Epithelial(149;1.08e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.00375)|Lung(261;0.00487)		GCACGGCAGCCTCTTGGATTT	0.378000													40	44					4.10826e-27	5.96497e-27	0.323286	1	0
PDP2	57546	broad.mit.edu	37	16	66918447	66918447	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:66918447G>A	ENST00000311765.2	+	2	594	c.260G>A	c.(259-261)cGa>cAa	p.R87Q	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	87					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		GAAGTGCTTCGAGCTGGCGAG	0.488000													66	98					0	0	0.323286	0	0
RIF1	55183	broad.mit.edu	37	2	152319744	152319744	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:152319744C>T	ENST00000243326.4	+	29	4193	c.3710C>T	c.(3709-3711)cCa>cTa	p.P1237L	RIF1_ENST00000444746.2_Missense_Mutation_p.P1237L|RIF1_ENST00000430328.2_Missense_Mutation_p.P1237L|RIF1_ENST00000428287.2_Missense_Mutation_p.P1237L|RIF1_ENST00000453091.2_Missense_Mutation_p.P1237L			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1237					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		CCTTTTAGTCCATCCCCCTTG	0.383000													54	83					0	0	0.323286	0	0
ADH6	130	broad.mit.edu	37	4	100129911	100129911	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:100129911T>G	ENST00000394897.1	-	6	824	c.742A>C	c.(742-744)Aag>Cag	p.K248Q	RP11-696N14.1_ENST00000506160.1_RNA|ADH6_ENST00000394899.2_Missense_Mutation_p.K248Q|RP11-696N14.1_ENST00000500358.2_RNA|ADH6_ENST00000407820.2_Missense_Mutation_p.K39Q|ADH6_ENST00000237653.7_Missense_Mutation_p.K248Q|ADH6_ENST00000504257.1_5'UTR|RP11-696N14.1_ENST00000506454.1_RNA			P28332	ADH6_HUMAN	alcohol dehydrogenase 6 (class V)	248					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			breast(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(2)	20				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	ATGGGTTTCTTTAAGTCCTGA	0.438000													101	358					0	0	0.323286	0	0
DPEP3	64180	broad.mit.edu	37	16	68011701	68011701	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:68011701A>C	ENST00000268793.4	-	6	1236	c.863T>G	c.(862-864)aTg>aGg	p.M288R		NM_001129758.1|NM_022357.3	NP_001123230.1|NP_071752.3	Q9H4B8	DPEP3_HUMAN	dipeptidase 3	263					meiosis	anchored to membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			breast(4)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(2)	20		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0117)|Epithelial(162;0.0481)|all cancers(182;0.236)		ATCTATCATCATGCCCAGGCG	0.493000													20	28					0	0	0.219247	0	0
RFT1	91869	broad.mit.edu	37	3	53126615	53126615	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:53126615C>G	ENST00000296292.3	-	12	1289	c.1228G>C	c.(1228-1230)Gcc>Ccc	p.A410P	RFT1_ENST00000394738.3_Missense_Mutation_p.A371P|RP11-894J14.5_ENST00000607203.1_Intron	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	410					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		GAGGACAGGGCCAGCATCACA	0.542000													22	34					0	0	0.279207	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27809349	27809349	+	Missense_Mutation	SNP	G	G	A	rs34347226	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:27809349G>A	ENST00000396319.2	+	5	596	c.508G>A	c.(508-510)Gtt>Att	p.V170I	TAX1BP1_ENST00000543117.1_Missense_Mutation_p.V170I|TAX1BP1_ENST00000265393.6_Missense_Mutation_p.V170I|TAX1BP1_ENST00000409980.1_Missense_Mutation_p.V170I|TAX1BP1_ENST00000433216.2_Missense_Mutation_p.V13I	NM_006024.6	NP_006015.4	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I) binding protein 1	170					anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(8)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31			GBM - Glioblastoma multiforme(3;0.0823)			GTTAATTGCCGTTCTGGAAAA	0.333000													35	127					0	0	0.257332	0	0
NLGN4X	57502	broad.mit.edu	37	X	5827247	5827247	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:5827247C>A	ENST00000381095.3	-	4	1286	c.659G>T	c.(658-660)gGc>gTc	p.G220V	NLGN4X_ENST00000381092.1_Missense_Mutation_p.G220V|NLGN4X_ENST00000381093.2_Missense_Mutation_p.G240V|NLGN4X_ENST00000538097.1_Missense_Mutation_p.G220V|NLGN4X_ENST00000275857.6_Missense_Mutation_p.G220V	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	220					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						CCCATAGTTGCCTTTTGCTGC	0.483000													102	5					3.29639e-60	5.77754e-60	0.323286	1	0
TAF7L	54457	broad.mit.edu	37	X	100530248	100530248	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:100530248C>A	ENST00000372907.3	-	12	1317	c.1306G>T	c.(1306-1308)Gag>Tag	p.E436*	TAF7L_ENST00000372905.2_Nonsense_Mutation_p.E276*|TAF7L_ENST00000324762.6_Nonsense_Mutation_p.E276*|TAF7L_ENST00000356784.1_Nonsense_Mutation_p.E350*	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	436					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						TCAAGCTGCTCCAGCACAGAC	0.338000													93	17					9.06123e-46	1.49907e-45	0.323286	1	0
DENND4A	10260	broad.mit.edu	37	15	65998502	65998502	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:65998502C>T	ENST00000443035.3	-	15	2229	c.2014G>A	c.(2014-2016)Gaa>Aaa	p.E672K	DENND4A_ENST00000431932.2_Missense_Mutation_p.E672K	NM_001144823.1	NP_001138295.1	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A	672					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(11)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	51						ACAGTGTGTTCACTTTTGAAA	0.393000													24	25					0	0	0.324025	0	0
RBM15	64783	broad.mit.edu	37	1	110883840	110883840	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:110883840G>T	ENST00000369784.3	+	1	2713	c.1813G>T	c.(1813-1815)Gtg>Ttg	p.V605L	RBM15_ENST00000487146.2_Missense_Mutation_p.V605L|RBM15_ENST00000602849.1_Missense_Mutation_p.V605L	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	605					interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGCTACTTCTGTGCCTGCTTA	0.577000			T	MKL1	acute megakaryocytic leukemia								10	9					1.49906e-05	1.59102e-05	0.119110	1	0
ECEL1	9427	broad.mit.edu	37	2	233345122	233345122	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:233345122G>T	ENST00000304546.1	-	17	2425	c.2215C>A	c.(2215-2217)Cct>Act	p.P739T	ECEL1_ENST00000409941.1_Missense_Mutation_p.P737T	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	739					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TAGTGCTCAGGGGCATGCTTG	0.622000													18	52					1.33986e-20	1.80808e-20	0.309145	1	0
SERPINB4	6318	broad.mit.edu	37	18	61308221	61308221	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:61308221T>C	ENST00000341074.5	-	5	471	c.356A>G	c.(355-357)tAt>tGt	p.Y119C	SERPINB4_ENST00000356424.6_Missense_Mutation_p.Y119C	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						GGCATCTAAATATTCCTTTGA	0.338000													34	85					0	0	0.279185	0	0
NFATC3	4775	broad.mit.edu	37	16	68225225	68225225	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:68225225C>G	ENST00000349223.5	+	9	2877	c.2653C>G	c.(2653-2655)Cat>Gat	p.H885D	NFATC3_ENST00000329524.4_Missense_Mutation_p.H885D|NFATC3_ENST00000575270.1_Missense_Mutation_p.H885D|NFATC3_ENST00000535127.2_3'UTR|NFATC3_ENST00000346183.3_Missense_Mutation_p.H885D	NM_173163.2	NP_775186.1	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	885					inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	44		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		AATGGGATATCATTGTTCAAA	0.428000													42	71					0	0	0.301197	0	0
DST	667	broad.mit.edu	37	6	56335963	56335963	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:56335963T>A	ENST00000370754.5	-	95	22168	c.22169A>T	c.(22168-22170)gAt>gTt	p.D7390V	DST_ENST00000370769.4_Missense_Mutation_p.D7212V|DST_ENST00000312431.6_3'UTR|DST_ENST00000370788.2_Missense_Mutation_p.D5015V|DST_ENST00000244364.6_Missense_Mutation_p.D4798V|DST_ENST00000361203.3_Missense_Mutation_p.D7101V|DST_ENST00000421834.2_Missense_Mutation_p.D5097V|DST_ENST00000446842.2_Missense_Mutation_p.D6886V			Q03001	DYST_HUMAN	dystonin	7210					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CTGGTCTTTATCAATTCTCCT	0.368000													23	47					0	0	0.309145	0	0
FAM65B	9750	broad.mit.edu	37	6	24848321	24848321	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:24848321G>T	ENST00000259698.4	-	12	1184	c.1009C>A	c.(1009-1011)Cag>Aag	p.Q337K	FAM65B_ENST00000540914.1_Missense_Mutation_p.Q337K|FAM65B_ENST00000378023.4_Missense_Mutation_p.Q337K|FAM65B_ENST00000538035.1_Missense_Mutation_p.Q366K|FAM65B_ENST00000510784.2_Missense_Mutation_p.Q371K	NM_014722.2	NP_055537.2	Q9Y4F9	FA65B_HUMAN	family with sequence similarity 65, member B	337					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	25						ATTCTCCTCTGAAGGGCTGCT	0.517000													37	49					7.04047e-22	9.66505e-22	0.225048	1	0
CACNA1E	777	broad.mit.edu	37	1	181701863	181701863	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:181701863C>G	ENST00000526775.1	+	19	2749	c.2584C>G	c.(2584-2586)Cca>Gca	p.P862A	CACNA1E_ENST00000357570.5_Missense_Mutation_p.P832A|CACNA1E_ENST00000358338.5_Missense_Mutation_p.P813A|CACNA1E_ENST00000367567.4_Missense_Mutation_p.P488A|CACNA1E_ENST00000367570.1_Missense_Mutation_p.P881A|CACNA1E_ENST00000367573.2_Missense_Mutation_p.P881A|CACNA1E_ENST00000360108.3_Missense_Mutation_p.P862A	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	881					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCAGCGGGAGCCACCATGGCT	0.672000													6	29					0	0	0.264190	0	0
BGLAP	632	broad.mit.edu	37	1	156212028	156212028	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:156212028A>T	ENST00000368272.4	+	1	276	c.6A>T	c.(4-6)agA>agT	p.R2S	PMF1-BGLAP_ENST00000320139.5_Intron|PMF1-BGLAP_ENST00000368276.4_Intron|PMF1_ENST00000567140.1_Intron|PMF1_ENST00000565805.1_Intron|PMF1-BGLAP_ENST00000490491.1_Intron	NM_199173.4	NP_954642.1	P02818	OSTCN_HUMAN	bone gamma-carboxyglutamate (gla) protein	2					bone mineralization|cell adhesion|odontogenesis|regulation of bone mineralization|regulation of bone resorption|regulation of osteoclast differentiation		calcium ion binding|hydroxyapatite binding|structural constituent of bone			large_intestine(3)|lung(1)|urinary_tract(1)	5	Hepatocellular(266;0.158)				Phytonadione(DB01022)	ACACCATGAGAGCCCTCACAC	0.672000													5	23					0	0	0.217242	0	0
TACC1	6867	broad.mit.edu	37	8	38681544	38681544	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:38681544G>T	ENST00000379931.3	+	4	1806		c.e4+1		TACC1_ENST00000519416.1_Intron|TACC1_ENST00000522752.1_Intron|TACC1_ENST00000518415.1_Intron|TACC1_ENST00000520611.1_Intron|TACC1_ENST00000520615.1_Intron|TACC1_ENST00000330691.6_Splice_Site|TACC1_ENST00000520973.1_Intron|TACC1_ENST00000276520.8_Intron|TACC1_ENST00000317827.4_Intron|TACC1_ENST00000348567.4_Intron|TACC1_ENST00000520340.1_Intron|TACC1_ENST00000443286.2_Intron			O75410	TACC1_HUMAN	transforming, acidic coiled-coil containing protein 1						cell cycle|cell division	intermediate filament cytoskeleton|microtubule organizing center|nucleus	protein binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(3)	17		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.065)	LUSC - Lung squamous cell carcinoma(45;1.7e-09)|COAD - Colon adenocarcinoma(9;0.235)			GTTTTCTGTTGTAAGTACTCC	0.428000													49	8					6.14515e-18	7.96965e-18	0.323286	1	0
USP31	57478	broad.mit.edu	37	16	23099057	23099057	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:23099057C>A	ENST00000219689.7	-	8	1514	c.1515G>T	c.(1513-1515)acG>acT	p.T505T		NM_020718.3	NP_065769.3	Q70CQ4	UBP31_HUMAN	ubiquitin specific peptidase 31	505					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(17)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	57				GBM - Glioblastoma multiforme(48;0.0187)		GAATGCAAACCGTGGGCCTCA	0.393000													34	58					9.04072e-19	1.18691e-18	0.183431	1	0
SYNJ1	8867	broad.mit.edu	37	21	34003353	34003353	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:34003353C>G	ENST00000382491.3	-	28	4657	c.4533G>C	c.(4531-4533)acG>acC	p.T1511T	SYNJ1_ENST00000433931.2_Silent_p.T1597T|SYNJ1_ENST00000382499.2_3'UTR|SYNJ1_ENST00000357345.3_3'UTR|SYNJ1_ENST00000322229.7_Silent_p.T1558T	NM_001160306.1	NP_001153778.1	O43426	SYNJ1_HUMAN	synaptojanin 1	1558	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						AGGCCAAGGTCGTGAAAGGAT	0.522000													48	2					0	0	0.323286	0	0
TBX5	6910	broad.mit.edu	37	12	114793495	114793495	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:114793495C>A	ENST00000310346.4	-	9	2065	c.1399G>T	c.(1399-1401)Gtc>Ttc	p.V467F	TBX5_ENST00000405440.2_Missense_Mutation_p.V467F|TBX5_ENST00000349716.5_Missense_Mutation_p.V417F	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	467					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		CACTGCCTGACCACAGGCTGG	0.652000													19	23					5.26018e-13	6.34623e-13	0.234183	1	0
SUN3	256979	broad.mit.edu	37	7	48065474	48065474	+	Splice_Site	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:48065474C>G	ENST00000453192.2	-	2	293	c.50_splice	c.e2+1	p.R17_splice	SUN3_ENST00000412142.1_5'UTR|SUN3_ENST00000297325.4_Splice_Site_p.G62_splice|SUN3_ENST00000395572.2_Splice_Site_p.G62_splice			Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 3	0						integral to membrane				central_nervous_system(1)|endometrium(3)|large_intestine(8)|liver(1)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GAAGACTTACCTACAAGAAGA	0.333000													7	51					0	0	0.248553	0	0
SFRP2	6423	broad.mit.edu	37	4	154709985	154709985	+	Translation_Start_Site	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:154709985C>T	ENST00000274063.4	-	1	287	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_003013.2	NP_003004.1	Q96HF1	SFRP2_HUMAN	secreted frizzled-related protein 2	1					brain development|cardiac left ventricle morphogenesis|cell-cell signaling|dermatome development|hemopoietic stem cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|negative regulation of cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|outflow tract morphogenesis|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell adhesion mediated by integrin|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of fat cell differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of stem cell division|sclerotome development	cytoplasm|extracellular matrix|extracellular space|plasma membrane	fibronectin binding|integrin binding|PDZ domain binding|receptor agonist activity|Wnt receptor activity|Wnt-protein binding			breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	16	all_hematologic(180;0.093)	Renal(120;0.117)				GGCCCTGCAGCATCGTGGGCG	0.731000													8	3					0	0	0.307466	0	0
P4HA2	8974	broad.mit.edu	37	5	131539500	131539500	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:131539500C>A	ENST00000401867.1	-	11	1760	c.1192G>T	c.(1192-1194)Gta>Tta	p.V398L	P4HA2_ENST00000166534.4_Missense_Mutation_p.V398L|P4HA2_ENST00000379086.1_Missense_Mutation_p.V398L|P4HA2_ENST00000379104.2_Missense_Mutation_p.V398L|P4HA2_ENST00000379100.2_Missense_Mutation_p.V398L|P4HA2_ENST00000360568.3_Missense_Mutation_p.V398L			O15460	P4HA2_HUMAN	prolyl 4-hydroxylase, alpha polypeptide II	398						endoplasmic reticulum lumen	electron carrier activity|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 4-dioxygenase activity|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(8)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		all_cancers(142;0.103)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Proline(DB00172)|Succinic acid(DB00139)	CGACGATTTACTCGGGCCACA	0.498000													14	15					3.41278e-10	3.90158e-10	0.160694	1	0
GPR162	27239	broad.mit.edu	37	12	6936304	6936304	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:6936304A>C	ENST00000311268.3	+	5	2489	c.1702A>C	c.(1702-1704)Agt>Cgt	p.S568R	GPR162_ENST00000382315.3_Missense_Mutation_p.S264R|GPR162_ENST00000428545.2_Missense_Mutation_p.S284R	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	568						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						GGGTGAAGAAAGTGCAAGGGC	0.632000													6	35					0	0	0.217242	0	0
ADAM30	11085	broad.mit.edu	37	1	120438854	120438854	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:120438854C>A	ENST00000369400.1	-	1	264	c.106G>T	c.(106-108)Ggg>Tgg	p.G36W		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	36					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.G36W(1)		NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		TCAAACTCCCCTTCAGGGTGA	0.502000													38	57					3.62531e-18	4.72144e-18	0.203993	1	0
LPA	4018	broad.mit.edu	37	6	160961173	160961173	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:160961173G>T	ENST00000447678.1	-	37	5757	c.5637C>A	c.(5635-5637)caC>caA	p.H1879Q	LPA_ENST00000316300.5_Missense_Mutation_p.H1879Q|LPA_ENST00000484276.1_5'UTR	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4387	Kringle 17.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TCACTTCTTGGTGTGCACCCA	0.468000													110	217					3.21087e-66	5.68233e-66	0.323286	1	0
CCDC158	339965	broad.mit.edu	37	4	77290615	77290615	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:77290615G>T	ENST00000388914.3	-	10	1463	c.1311C>A	c.(1309-1311)gcC>gcA	p.A437A		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	437										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						CGCTCTTCAAGGCCTTGAGCA	0.577000													4	24					0.184627	0.186433	0.184627	1	0
KCNK10	54207	broad.mit.edu	37	14	88729606	88729606	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:88729606C>A	ENST00000340700.5	-	2	778	c.327G>T	c.(325-327)aaG>aaT	p.K109N	KCNK10_ENST00000312350.5_Missense_Mutation_p.K114N|KCNK10_ENST00000319231.5_Missense_Mutation_p.K114N	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	109					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						GGAATTCCGCCTTCTCCAAGG	0.577000													55	104					6.20203e-27	8.97976e-27	0.323286	1	0
OR4Q3	441669	broad.mit.edu	37	14	20216351	20216351	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20216351C>T	ENST00000331723.1	+	1	765	c.765C>T	c.(763-765)tgC>tgT	p.C255C		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCGTGCCATGCGTATTCATCT	0.473000													27	719					0	0	0.183431	0	0
TRIM48	79097	broad.mit.edu	37	11	55036730	55036730	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55036730G>T	ENST00000417545.2	+	5	677	c.591G>T	c.(589-591)gtG>gtT	p.V197V		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	181						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GTGAGTCCGTGCTGCTGCACA	0.468000													19	30					5.03518e-11	5.88008e-11	0.189662	1	0
NAV3	89795	broad.mit.edu	37	12	78400870	78400870	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:78400870G>A	ENST00000397909.2	+	8	1725	c.1552G>A	c.(1552-1554)Gaa>Aaa	p.E518K	NAV3_ENST00000536525.2_Missense_Mutation_p.E518K|NAV3_ENST00000228327.6_Missense_Mutation_p.E518K|NAV3_ENST00000266692.7_Missense_Mutation_p.E518K			Q8IVL0	NAV3_HUMAN	neuron navigator 3	518						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AGCTAAGAAGGAAAGCTTAAT	0.453000										HNSCC(70;0.22)			25	131					0	0	0.153744	0	0
NUP93	9688	broad.mit.edu	37	16	56871538	56871538	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:56871538G>T	ENST00000564887.1	+	16	2178	c.1549G>T	c.(1549-1551)Gag>Tag	p.E517*	NUP93_ENST00000308159.5_Nonsense_Mutation_p.E640*|NUP93_ENST00000542526.1_Nonsense_Mutation_p.E517*|NUP93_ENST00000569842.1_Nonsense_Mutation_p.E640*	NM_001242795.1	NP_001229724.1	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	640					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|endometrium(6)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						CAAGGTACTGGAGCTGATGAA	0.458000													43	138					9.77497e-20	1.29983e-19	0.323286	1	0
MINA	84864	broad.mit.edu	37	3	97677986	97677986	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:97677986C>G	ENST00000333396.6	-	4	1172	c.590G>C	c.(589-591)cGc>cCc	p.R197P	MINA_ENST00000360258.4_Missense_Mutation_p.R197P|MINA_ENST00000330299.2_Missense_Mutation_p.R197P|MINA_ENST00000394198.2_Missense_Mutation_p.R197P	NM_001042533.2|NM_032778.5	NP_001035998.1|NP_116167.3	Q8IUF8	MINA_HUMAN	MYC induced nuclear antigen	197	JmjC.				ribosome biogenesis	cytoplasm|nucleolus				breast(2)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)	13						GTGGTAGAGGCGCCAGTGTTT	0.562000													32	31					0	0	0.173368	0	0
IFT46	56912	broad.mit.edu	37	11	118428453	118428453	+	Splice_Site	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:118428453C>G	ENST00000264020.2	-	4	575	c.198_splice	c.e4+1	p.K66_splice	IFT46_ENST00000530872.1_Splice_Site_p.K66_splice|IFT46_ENST00000264021.3_Intron	NM_020153.3	NP_064538.3	Q9NQC8	IFT46_HUMAN	intraflagellar transport 46 homolog (Chlamydomonas)	15					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9						TATAACCTACCTTTCTGTGCT	0.448000													38	112					0	0	0.257332	0	0
ZNF536	9745	broad.mit.edu	37	19	30935452	30935452	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:30935452C>T	ENST00000355537.3	+	2	1130	c.983C>T	c.(982-984)tCg>tTg	p.S328L		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	328					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ACGGCCGAGTCGGCCCAGGGC	0.647000													94	152					0	0	0.323286	0	0
IL16	3603	broad.mit.edu	37	15	81592114	81592114	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:81592114C>A	ENST00000394660.2	+	14	2807	c.2447C>A	c.(2446-2448)aCc>aAc	p.T816N	IL16_ENST00000560230.1_3'UTR|IL16_ENST00000302987.4_Missense_Mutation_p.T816N|IL16_ENST00000394652.2_Missense_Mutation_p.T115N	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	816					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GCCTTGTCCACCCAGCCAGCA	0.577000													11	45					0.00244969	0.0025205	0.119110	1	0
KLHL13	90293	broad.mit.edu	37	X	117079539	117079539	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:117079539C>A	ENST00000262820.3	-	2	1008		c.e2-1		KLHL13_ENST00000541812.1_Splice_Site|KLHL13_ENST00000540167.1_Splice_Site|KLHL13_ENST00000371882.1_Splice_Site|KLHL13_ENST00000371878.1_Splice_Site|KLHL13_ENST00000539496.1_Splice_Site|KLHL13_ENST00000469946.1_Splice_Site|KLHL13_ENST00000545703.1_Splice_Site|KLHL13_ENST00000371876.1_5'UTR	NM_033495.3	NP_277030.2	Q9P2N7	KLH13_HUMAN	kelch-like family member 13						cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex		p.?(1)		NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CACGAGAGATCTGAAAGTTTT	0.378000													29	7					9.65021e-13	1.1593e-12	0.153744	1	0
DENND5B	160518	broad.mit.edu	37	12	31566441	31566441	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:31566441T>A	ENST00000389082.5	-	13	2874	c.2610A>T	c.(2608-2610)atA>atT	p.I870I	DENND5B_ENST00000536562.1_Silent_p.I905I|DENND5B_ENST00000306833.6_Silent_p.I905I	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	870	RUN 1.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GAGACAGTCTTATCCACGCCC	0.403000													26	5					0	0	0.294199	0	0
TCN1	6947	broad.mit.edu	37	11	59620692	59620692	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:59620692G>A	ENST00000257264.3	-	8	1328	c.1224C>T	c.(1222-1224)ggC>ggT	p.G408G		NM_001062.3	NP_001053.2	P20061	TCO1_HUMAN	transcobalamin I (vitamin B12 binding protein, R binder family)	408					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCAGTGGTTCGCCTCCACTCA	0.522000													99	199					0	0	0.323286	0	0
OR6K3	391114	broad.mit.edu	37	1	158687131	158687131	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158687131A>C	ENST00000368146.1	-	1	822	c.823T>G	c.(823-825)Ttg>Gtg	p.L275V	OR6K3_ENST00000368145.1_Missense_Mutation_p.L259V			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L275V(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					CTGAAACGCAAGTACATGAGT	0.463000													37	223					0	0	0.214465	0	0
PROK2	60675	broad.mit.edu	37	3	71821964	71821964	+	Missense_Mutation	SNP	G	G	A	rs144953748		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:71821964G>A	ENST00000353065.3	-	3	391	c.238C>T	c.(238-240)Cgg>Tgg	p.R80W	PROK2_ENST00000295619.3_Missense_Mutation_p.R101W	NM_021935.3	NP_068754.1	Q9HC23	PROK2_HUMAN	prokineticin 2	101					activation of MAPK activity|angiogenesis|anti-apoptosis|cell proliferation|chemotaxis|elevation of cytosolic calcium ion concentration|inflammatory response|neuropeptide signaling pathway|positive regulation of smooth muscle contraction|sensory perception of pain|spermatogenesis	extracellular region	G-protein-coupled receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6		Prostate(10;0.00899)		BRCA - Breast invasive adenocarcinoma(55;1.89e-05)|Epithelial(33;0.000173)|LUSC - Lung squamous cell carcinoma(21;0.00168)|Lung(16;0.00306)		TGCATCCTCCGCCCAAAAAAT	0.398000													5	99					0	0	0.217242	0	0
PRSS1	5644	broad.mit.edu	37	7	142460763	142460763	+	Silent	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142460763A>C	ENST00000486171.1	+	6	695	c.678A>C	c.(676-678)ggA>ggC	p.G226G	PRSS1_ENST00000311737.7_Silent_p.G212G			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	212	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			AGCTCCAAGGAGTTGTCTCCT	0.507000													36	156					0	0	0.203993	0	0
ACTN2	88	broad.mit.edu	37	1	236894539	236894539	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:236894539C>A	ENST00000366578.4	+	7	788	c.622C>A	c.(622-624)Ccc>Acc	p.P208T	ACTN2_ENST00000542672.1_Missense_Mutation_p.P208T|ACTN2_ENST00000492634.1_3'UTR	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	208	Actin-binding.|CH 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			ACAGGATGACCCCATAGGAAA	0.373000													14	210					4.7546e-09	5.31973e-09	0.146539	1	0
IL36B	27177	broad.mit.edu	37	2	113780347	113780347	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:113780347C>A	ENST00000259213.4	-	6	506	c.399G>T	c.(397-399)aaG>aaT	p.K133N		NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	133					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						TCTTCCACTTCTTTCTACCTG	0.433000													52	102					3.07002e-29	4.55138e-29	0.323286	1	0
APBB1	322	broad.mit.edu	37	11	6432455	6432455	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:6432455C>G	ENST00000389906.2	-	2	222	c.123G>C	c.(121-123)caG>caC	p.Q41H	APBB1_ENST00000299402.6_Missense_Mutation_p.Q41H|APBB1_ENST00000311051.3_Missense_Mutation_p.Q41H|APBB1_ENST00000533407.1_Intron	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	41					apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		CAGCTGTGGCCTGCAGCTTGG	0.662000													67	119					0	0	0.323286	0	0
KHDC1	80759	broad.mit.edu	37	6	73952133	73952133	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:73952133G>A	ENST00000423730.3	-	2	543	c.108C>T	c.(106-108)atC>atT	p.I36I	KHDC1_ENST00000257765.5_Silent_p.I36I|KHDC1_ENST00000370384.3_Silent_p.I109I																							ACTCACCGAAGATGAGCTCCT	0.522000													14	25					0	0	0.119110	0	0
QSOX1	5768	broad.mit.edu	37	1	180163465	180163465	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:180163465G>T	ENST00000367602.3	+	11	1480	c.1406G>T	c.(1405-1407)aGt>aTt	p.S469I	QSOX1_ENST00000367600.5_Missense_Mutation_p.S469I			O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1	469	ERV/ALR sulfhydryl oxidase.				cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						CGGGTGGGGAGTCCCAACGCC	0.617000													32	68					4.11147e-13	4.97198e-13	0.193644	1	0
STH	246744	broad.mit.edu	37	17	44077011	44077011	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:44077011G>T	ENST00000537309.1	+	1	396	c.366G>T	c.(364-366)caG>caT	p.Q122H	MAPT_ENST00000340799.5_Intron|MAPT_ENST00000262410.5_Intron|MAPT_ENST00000431008.3_Intron|MAPT_ENST00000347967.5_Intron|MAPT_ENST00000570299.1_Intron|MAPT_ENST00000344290.5_Intron|MAPT_ENST00000571987.1_Intron|MAPT_ENST00000535772.1_Intron|MAPT_ENST00000446361.3_Intron|MAPT_ENST00000351559.5_Intron|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000415613.2_Intron|MAPT_ENST00000420682.2_Intron|MAPT_ENST00000574436.1_Intron|MAPT_ENST00000576518.1_Intron	NM_001007532.2	NP_001007533.1	Q8IWL8	STH_HUMAN	saitohin	122						cytoplasm|nucleus				endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						GTGAGAGTCAGGCGACCTCAT	0.577000													9	11					9.70103e-10	1.10294e-09	0.069234	1	0
DSG1	1828	broad.mit.edu	37	18	28934648	28934648	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:28934648T>C	ENST00000257192.4	+	15	2701	c.2489T>C	c.(2488-2490)cTg>cCg	p.L830P	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG1_ENST00000462981.2_Missense_Mutation_p.L189P	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	830					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			CTCGATCCTCTGGGCTATGGT	0.517000													6	601					0	0	0.217242	0	0
CHD5	26038	broad.mit.edu	37	1	6212594	6212594	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:6212594G>T	ENST00000262450.3	-	6	847	c.748C>A	c.(748-750)Cct>Act	p.P250T	CHD5_ENST00000378021.1_5'UTR	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	250	Lys-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CTCACTCCAGGCCCTGAAAAA	0.532000													28	46					4.22769e-11	4.94642e-11	0.116897	1	0
OR4A16	81327	broad.mit.edu	37	11	55111453	55111453	+	Silent	SNP	C	C	T	rs79231280	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55111453C>T	ENST00000314721.2	+	1	827	c.777C>T	c.(775-777)ccC>ccT	p.P259P		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						ATGTTAGACCCGTTTCCAACT	0.388000													29	64					0	0	0.134883	0	0
MCOLN2	255231	broad.mit.edu	37	1	85397235	85397235	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:85397235G>C	ENST00000370608.3	-	12	1419	c.1352C>G	c.(1351-1353)aCa>aGa	p.T451R	MCOLN2_ENST00000284027.5_Missense_Mutation_p.T423R	NM_153259.2	NP_694991.2	Q8IZK6	MCLN2_HUMAN	mucolipin 2	451						integral to membrane	ion channel activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	18				all cancers(265;0.0111)|Epithelial(280;0.0263)|OV - Ovarian serous cystadenocarcinoma(397;0.217)		CTCAGCAACTGTGTTCAGATT	0.393000													53	124					0	0	0.323286	0	0
BCAS1	8537	broad.mit.edu	37	20	52570011	52570011	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:52570011T>C	ENST00000395961.3	-	11	1806	c.1640A>G	c.(1639-1641)gAg>gGg	p.E547G	BCAS1_ENST00000371435.2_Missense_Mutation_p.E469G|BCAS1_ENST00000434986.2_Missense_Mutation_p.E213G|BCAS1_ENST00000371440.3_Missense_Mutation_p.E556G	NM_003657.2	NP_003648.2	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	547						cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(23)|ovary(2)|skin(2)|stomach(1)|urinary_tract(1)	37	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CTGCCGCTTCTCAGGTCTCTT	0.547000													25	83					0	0	0.125774	0	0
SIL1	64374	broad.mit.edu	37	5	138282915	138282915	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:138282915T>A	ENST00000394817.2	-	10	1416	c.1277A>T	c.(1276-1278)cAg>cTg	p.Q426L	SIL1_ENST00000509534.1_Missense_Mutation_p.Q433L|SIL1_ENST00000515008.1_5'UTR|SIL1_ENST00000265195.5_Missense_Mutation_p.Q426L	NM_022464.4	NP_071909.1	Q9H173	SIL1_HUMAN	SIL1 nucleotide exchange factor	426					intracellular protein transport|protein folding|transmembrane transport	endoplasmic reticulum lumen	unfolded protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTACTCAGCCTGCAGGCTGGC	0.657000									Marinesco-Sjgren syndrome				8	5					0	0	0.080935	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115526456	115526456	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:115526456G>T	ENST00000361048.1	+	4	530	c.203G>T	c.(202-204)cGa>cTa	p.R68L	PLEKHS1_ENST00000369312.4_5'UTR|PLEKHS1_ENST00000369310.3_Missense_Mutation_p.R62L	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		CATCATCACCGAGGTTCCATT	0.348000													30	48					4.65686e-17	5.97692e-17	0.193644	1	0
COL2A1	1280	broad.mit.edu	37	12	48370314	48370314	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:48370314C>G	ENST00000380518.3	-	49	3636	c.3472G>C	c.(3472-3474)Ggt>Cgt	p.G1158R	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Missense_Mutation_p.G1089R	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	1158	Triple-helical region.		G -> A (in STL1).		axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CCAGAAGGACCAGCAGGACCA	0.547000													17	71					0	0	0.189662	0	0
ARID4A	5926	broad.mit.edu	37	14	58817917	58817917	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:58817917G>T	ENST00000355431.3	+	16	1904	c.1531G>T	c.(1531-1533)Gag>Tag	p.E511*	ARID4A_ENST00000348476.3_Nonsense_Mutation_p.E511*|ARID4A_ENST00000395168.3_Nonsense_Mutation_p.E511*|ARID4A_ENST00000431317.2_Nonsense_Mutation_p.E511*	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	511					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TGAAACTGCAGAGAAAAAAGA	0.299000													49	186					9.45407e-15	1.17587e-14	0.323286	1	0
NLRP8	126205	broad.mit.edu	37	19	56477721	56477721	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:56477721C>T	ENST00000291971.3	+	5	2427	c.2356C>T	c.(2356-2358)Ccc>Tcc	p.P786S	NLRP8_ENST00000590542.1_Missense_Mutation_p.P786S	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	786						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GCTGAGATCCCCCCGGTGCCG	0.547000													79	2					0	0	0.323286	0	0
NUAK1	9891	broad.mit.edu	37	12	106500286	106500286	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:106500286A>T	ENST00000261402.2	-	2	1637	c.258T>A	c.(256-258)atT>atA	p.I86I		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	86	Protein kinase.			I -> V (in Ref. 3; BAB55026).			ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TGTCCTTACGAATGGATTTTA	0.358000													61	9					0	0	0.323286	0	0
OR6N2	81442	broad.mit.edu	37	1	158746545	158746545	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158746545T>G	ENST00000339258.1	-	1	880	c.881A>C	c.(880-882)aAc>aCc	p.N294T		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					GATTTCCTTGTTACGAAGACT	0.423000													164	448					0	0	0.323286	0	0
TBX22	50945	broad.mit.edu	37	X	79286130	79286130	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:79286130G>T	ENST00000442340.1	+	9	1213	c.723G>T	c.(721-723)gaG>gaT	p.E241D	TBX22_ENST00000373291.1_Missense_Mutation_p.E241D|TBX22_ENST00000373294.5_Missense_Mutation_p.E361D|TBX22_ENST00000373296.3_Missense_Mutation_p.E361D	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	361					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						CCTGTCCAGAGGCATACCTGC	0.473000													71	6					1.53134e-21	2.08923e-21	0.323286	1	0
RAVER2	55225	broad.mit.edu	37	1	65278516	65278516	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:65278516C>T	ENST00000294428.3	+	10	1854	c.1776C>T	c.(1774-1776)ccC>ccT	p.P592P	RAVER2_ENST00000430964.2_Silent_p.P131P|RAVER2_ENST00000371072.4_Silent_p.P579P			Q9HCJ3	RAVR2_HUMAN	ribonucleoprotein, PTB-binding 2	592						cytoplasm|nucleus	nucleotide binding|RNA binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	24						GTGTGTTGCCCAGTGTGTGCT	0.368000													19	44					0	0	0.249174	0	0
UTS2	10911	broad.mit.edu	37	1	7907835	7907835	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:7907835G>T	ENST00000361696.5	-	4	397	c.366C>A	c.(364-366)taC>taA	p.Y122*	UTS2_ENST00000054668.5_Nonsense_Mutation_p.Y137*|UTS2_ENST00000377516.2_Intron	NM_006786.3	NP_006777.1	O95399	UTS2_HUMAN	urotensin 2	122					muscle contraction|regulation of blood pressure|synaptic transmission	extracellular space	hormone activity			kidney(1)|lung(4)|urinary_tract(1)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;1.38e-20)|all_lung(118;1.29e-06)|Lung NSC(185;7.5e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.26e-71)|GBM - Glioblastoma multiforme(8;5.15e-36)|Colorectal(212;1.27e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000386)|KIRC - Kidney renal clear cell carcinoma(229;0.000894)|STAD - Stomach adenocarcinoma(132;0.000951)|READ - Rectum adenocarcinoma(331;0.0642)		TTCAGACACAGTATTTCCAGA	0.373000													64	139					4.98926e-31	7.52275e-31	0.323286	1	0
HERC1	8925	broad.mit.edu	37	15	63970559	63970559	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:63970559T>G	ENST00000443617.2	-	37	6642	c.6555A>C	c.(6553-6555)aaA>aaC	p.K2185N	RP11-317G6.1_ENST00000559303.2_RNA	NM_003922.3	NP_003913.3	Q15751	HERC1_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	2185	B30.2/SPRY.				protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			NS(3)|breast(9)|central_nervous_system(4)|endometrium(23)|haematopoietic_and_lymphoid_tissue(1)|kidney(12)|large_intestine(22)|liver(1)|lung(36)|ovary(7)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	132						TATCACAAATTTTCACCTATA	0.418000													6	35					0	0	0.307466	0	0
PLXNA1	5361	broad.mit.edu	37	3	126708358	126708358	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:126708358G>T	ENST00000251772.4	+	1	922	c.853G>T	c.(853-855)Gag>Tag	p.E285*	PLXNA1_ENST00000393409.2_Nonsense_Mutation_p.E308*			Q9UIW2	PLXA1_HUMAN	plexin A1	308	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		GGCGGGTGTGGAGTACCGCCT	0.632000													26	38					2.36697e-06	2.54886e-06	0.125774	1	0
BSN	8927	broad.mit.edu	37	3	49689788	49689788	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:49689788C>A	ENST00000296452.4	+	5	2913	c.2799C>A	c.(2797-2799)acC>acA	p.T933T		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	933					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCTTCAAGACCATTGAGCTCA	0.627000													31	71					2.48696e-23	3.47725e-23	0.183431	1	0
CLCN3	1182	broad.mit.edu	37	4	170601243	170601243	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:170601243C>T	ENST00000513761.1	+	3	762	c.203C>T	c.(202-204)tCt>tTt	p.S68F	CLCN3_ENST00000347613.4_Missense_Mutation_p.S68F|CLCN3_ENST00000360642.3_Missense_Mutation_p.S68F|CLCN3_ENST00000504131.2_Missense_Mutation_p.S51F	NM_001829.3	NP_001820.2	P51790	CLCN3_HUMAN	chloride channel, voltage-sensitive 3	68					endosomal lumen acidification	cell surface|early endosome membrane|Golgi membrane|integral to membrane|late endosome membrane|transport vesicle membrane	antiporter activity|ATP binding|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|voltage-gated chloride channel activity			breast(5)|endometrium(3)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	29		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0233)|LUSC - Lung squamous cell carcinoma(193;0.131)		ATTAACAGTTCTACACATTTA	0.363000													25	22					0	0	0.279207	0	0
ASTN1	460	broad.mit.edu	37	1	176853573	176853573	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:176853573C>A	ENST00000367654.2	-	19	3165	c.3152G>T	c.(3151-3153)tGg>tTg	p.W1051L	ASTN1_ENST00000424564.2_Missense_Mutation_p.W1043L|ASTN1_ENST00000361833.2_Missense_Mutation_p.W1043L|ASTN1_ENST00000367657.3_Missense_Mutation_p.W1043L			O14525	ASTN1_HUMAN	astrotactin 1	1051	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TGAGTGTTCCCACTCCAGGAC	0.537000													56	146					1.00798e-23	1.41703e-23	0.323286	1	0
KIFC3	3801	broad.mit.edu	37	16	57794777	57794777	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:57794777T>G	ENST00000379655.4	-	16	2350	c.2093A>C	c.(2092-2094)aAc>aCc	p.N698T	KIFC3_ENST00000539578.1_Missense_Mutation_p.N640T|KIFC3_ENST00000562903.1_Missense_Mutation_p.N559T|KIFC3_ENST00000543930.1_Missense_Mutation_p.N556T|KIFC3_ENST00000465878.2_Missense_Mutation_p.N559T|KIFC3_ENST00000445690.2_Missense_Mutation_p.N698T|KIFC3_ENST00000540079.2_Missense_Mutation_p.N596T|KIFC3_ENST00000421376.2_Missense_Mutation_p.N559T|KIFC3_ENST00000541240.1_Missense_Mutation_p.N720T	NM_005550.3	NP_005541.3	Q9BVG8	KIFC3_HUMAN	kinesin family member C3	698	Kinesin-motor.				epithelial cell-cell adhesion|microtubule-based movement|visual perception|zonula adherens maintenance	centrosome|cytoplasmic vesicle membrane|kinesin complex|microtubule|zonula adherens	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(3)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(199;0.224)				CAGCGACTTGTTGATGTGCTG	0.677000													4	9					0	0	0.217242	0	0
MUC3A	4584	broad.mit.edu	37	7	100552276	100552276	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100552276G>T	ENST00000319509.7	+	1	1027	c.1027G>T	c.(1027-1029)Gat>Tat	p.D343Y						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TGTTGAAATGGATCCCAGCAC	0.483000													25	140					1.5548e-18	2.03431e-18	0.324025	1	0
PRKCQ	5588	broad.mit.edu	37	10	6498683	6498683	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:6498683C>A	ENST00000263125.5	-	15	1699	c.1600G>T	c.(1600-1602)Gcc>Tcc	p.A534S	PRKCQ_ENST00000539722.1_Missense_Mutation_p.A409S|PRKCQ_ENST00000397176.2_Missense_Mutation_p.A534S	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	534	Protein kinase.				axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						TTCGTCTTGGCATCTCCTAAC	0.502000													108	170					2.85792e-54	4.91174e-54	0.323286	1	0
CAPZA3	93661	broad.mit.edu	37	12	18891236	18891236	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:18891236G>T	ENST00000317658.3	+	1	192	c.34G>T	c.(34-36)Gaa>Taa	p.E12*		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	12					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				GAAGGACAAGGAAAGAGTAAT	0.423000													75	298					2.28164e-27	3.31749e-27	0.323286	1	0
RETNLB	84666	broad.mit.edu	37	3	108475360	108475360	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:108475360G>T	ENST00000295755.6	-	2	401	c.203C>A	c.(202-204)cCt>cAt	p.P68H	RETNLB_ENST00000482939.1_5'UTR	NM_032579.2	NP_115968.1	Q9BQ08	RETNB_HUMAN	resistin like beta	68					cell proliferation	extracellular region	hormone activity			endometrium(1)|kidney(3)|lung(10)|prostate(1)|skin(1)	16						CTCACCAGCAGGGCAGGAGGA	0.547000													27	87					2.45108e-15	3.06831e-15	0.268233	1	0
FRAS1	80144	broad.mit.edu	37	4	79284775	79284775	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:79284775C>T	ENST00000264895.6	+	21	2971	c.2531C>T	c.(2530-2532)cCt>cTt	p.P844L	FRAS1_ENST00000325942.6_Missense_Mutation_p.P844L	NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	844					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						CACTGTGTTCCTGACTGCCCT	0.567000													10	23					0	0	0.080935	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803678	185803678	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:185803678A>T	ENST00000302277.6	+	4	4149	c.3555A>T	c.(3553-3555)ccA>ccT	p.P1185P		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1185						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TGGCTTTCCCATCTTTACCCC	0.483000													160	299					0	0	0.323286	0	0
RNF213	57674	broad.mit.edu	37	17	78317028	78317028	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:78317028A>T	ENST00000582970.1	+	27	6229	c.6086A>T	c.(6085-6087)cAg>cTg	p.Q2029L	RNF213_ENST00000336301.6_Missense_Mutation_p.Q102L|RNF213_ENST00000508628.2_Missense_Mutation_p.Q2078L	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			ATCGACCCTCAGGTGGATGAG	0.517000													3	38					0	0	0.115264	0	0
NID2	22795	broad.mit.edu	37	14	52486851	52486851	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:52486851C>T	ENST00000216286.5	-	13	2719	c.2720G>A	c.(2719-2721)tGc>tAc	p.C907Y	NID2_ENST00000541773.1_Missense_Mutation_p.C806Y	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	907	EGF-like 5; calcium-binding (Potential).					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					AGTATTGTAGCAGGTAGCTGC	0.463000													71	134					0	0	0.323286	0	0
CYP4F11	57834	broad.mit.edu	37	19	16025117	16025117	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:16025117G>A	ENST00000326742.7	-	10	1331	c.1330C>T	c.(1330-1332)Cag>Tag	p.Q444*	CYP4F11_ENST00000248041.7_Silent_p.P465P|CYP4F11_ENST00000402119.3_Silent_p.P465P			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	0					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						ATCCTTACCTGGGCCCTGCCG	0.557000													51	434					0	0	0.323286	0	0
SOBP	55084	broad.mit.edu	37	6	107955743	107955743	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:107955743C>A	ENST00000317357.5	+	6	2354	c.1695C>A	c.(1693-1695)aaC>aaA	p.N565K		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	565							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		TCATTCCGAACGCCCCTGGCG	0.692000													16	10					1.96292e-10	2.25656e-10	0.219247	1	0
DMRT3	58524	broad.mit.edu	37	9	990458	990458	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:990458C>T	ENST00000190165.2	+	2	910	c.872C>T	c.(871-873)tCa>tTa	p.S291L		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	291					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		AGCCGATCCTCAGTCACGGGA	0.582000													35	42					0	0	0.323286	0	0
IQCF3	401067	broad.mit.edu	37	3	51864588	51864588	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:51864588G>A	ENST00000456080.1	+	8	1401	c.236G>A	c.(235-237)cGg>cAg	p.R79Q	IQCF3_ENST00000437810.2_Missense_Mutation_p.R79Q|IQCF3_ENST00000440739.2_Missense_Mutation_p.R79Q|IQCF3_ENST00000462079.1_3'UTR|IQCF3_ENST00000446775.1_Missense_Mutation_p.R79Q|IQCF3_ENST00000444293.1_Silent_p.A42A			P0C7M6	IQCF3_HUMAN	IQ motif containing F3	79										endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CGTCAGCGGCGGCAGGCCCTG	0.637000													46	57					0	0	0.323286	0	0
TMEM244	253582	broad.mit.edu	37	6	130154670	130154670	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:130154670A>G	ENST00000438392.1	-	5	434	c.254T>C	c.(253-255)gTg>gCg	p.V85A	TMEM244_ENST00000368143.1_Missense_Mutation_p.V85A			Q5VVB8	CF191_HUMAN	transmembrane protein 244	85						integral to membrane											CCATTCTTCCACAACTGGAAC	0.348000													54	171					0	0	0.323286	0	0
DOCK10	55619	broad.mit.edu	37	2	225638017	225638017	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:225638017G>T	ENST00000409592.3	-	53	6156	c.6043C>A	c.(6043-6045)Caa>Aaa	p.Q2015K	DOCK10_ENST00000258390.7_Missense_Mutation_p.Q2021K			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	2021	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GTGCTCGATTGGCTAATTACT	0.423000													62	120					1.34159e-35	2.10482e-35	0.323286	1	0
TAGAP	117289	broad.mit.edu	37	6	159457474	159457474	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:159457474G>T	ENST00000367066.3	-	10	1912	c.1581C>A	c.(1579-1581)ggC>ggA	p.G527G	RP1-111C20.4_ENST00000607796.1_RNA|RP1-111C20.4_ENST00000606466.1_RNA|TAGAP_ENST00000326965.6_Silent_p.G349G|RP1-111C20.4_ENST00000607391.1_RNA|RP1-111C20.4_ENST00000606470.1_RNA	NM_054114.3	NP_473455.2	Q8N103	TAGAP_HUMAN	T-cell activation RhoGTPase activating protein	527					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			NS(1)|autonomic_ganglia(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(2)|skin(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		ATTTCCCAGAGCCCGCGCTGA	0.522000													74	79					2.51111e-31	3.80102e-31	0.323286	1	0
TBX10	347853	broad.mit.edu	37	11	67399882	67399882	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:67399882G>T	ENST00000335385.3	-	7	862	c.773_splice	c.e7-1	p.P259_splice		NM_005995.4	NP_005986.2	O75333	TBX10_HUMAN	T-box 10	259					anatomical structure morphogenesis|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|lung(4)|ovary(1)	7						GGGGCCACAGGCCTGAAAGAG	0.637000													11	28					0.000673444	0.000698011	0.069234	1	0
PBX4	80714	broad.mit.edu	37	19	19680275	19680275	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19680275C>A	ENST00000251203.8	-	5	1037	c.751G>T	c.(751-753)Ggc>Tgc	p.G251C		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	251							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						ATGGTGAGGCCGCCCTTCCTG	0.567000													30	107					1.56738e-10	1.81396e-10	0.203993	1	0
STRN	6801	broad.mit.edu	37	2	37129805	37129805	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:37129805G>A	ENST00000263918.4	-	5	589	c.581C>T	c.(580-582)aCg>aTg	p.T194M	STRN_ENST00000379213.2_Missense_Mutation_p.T182M	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein	194					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				TTCCCTGTCCGTGACATCACT	0.413000													64	91					0	0	0.323286	0	0
TBCCD1	55171	broad.mit.edu	37	3	186272162	186272162	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:186272162C>A	ENST00000424280.1	-	6	1904	c.1425G>T	c.(1423-1425)atG>atT	p.M475I	TBCCD1_ENST00000479590.1_5'UTR|TBCCD1_ENST00000446782.1_Missense_Mutation_p.M379I|TBCCD1_ENST00000338733.5_Missense_Mutation_p.M475I	NM_001134415.1	NP_001127887.1	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	475					cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		TGTCCCCTTCCATTTCAAAGG	0.433000													44	121					3.94638e-17	5.06924e-17	0.323286	1	0
OR2W1	26692	broad.mit.edu	37	6	29012534	29012534	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:29012534A>T	ENST00000377175.1	-	1	483	c.419T>A	c.(418-420)cTa>cAa	p.L140Q		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	140					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						CTTTAGACATAGATGTGGGTT	0.388000													50	147					0	0	0.323286	0	0
KCNH3	23416	broad.mit.edu	37	12	49948284	49948284	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:49948284G>T	ENST00000257981.6	+	11	2343	c.2083G>T	c.(2083-2085)Ggc>Tgc	p.G695C		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	695					regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						CTTCAGTCGTGGCCTCCGAGG	0.652000													10	35					3.86212e-05	4.08783e-05	0.069234	1	0
LINC01410	103352539	broad.mit.edu	37	9	66459809	66459809	+	RNA	SNP	A	A	G	rs28440808		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:66459809A>G	ENST00000424345.1	+	0	69																											tttctccaggatttgtcccca	0.338000													3	33					0	0	0.115264	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973479	46973479	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:46973479C>T	ENST00000313683.10	-	2	1119	c.814G>A	c.(814-816)Gag>Aag	p.E272K	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Missense_Mutation_p.E272K	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	272										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TCAGGATCCTCCAAGTTAGCT	0.512000													149	97					0	0	0.323286	0	0
MUT	4594	broad.mit.edu	37	6	49403324	49403324	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:49403324C>A	ENST00000274813.3	-	12	2096	c.1969G>T	c.(1969-1971)Gtg>Ttg	p.V657L		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	657	B12-binding.				fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TGCTGGGCCACTTCACGAGGA	0.423000													15	37					1.10513e-12	1.32402e-12	0.249174	1	0
UBC	7316	broad.mit.edu	37	12	125398153	125398153	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:125398153G>A	ENST00000536769.1	-	1	1741	c.165C>T	c.(163-165)acC>acT	p.T55T	UBC_ENST00000546120.1_Silent_p.T55T|UBC_ENST00000339647.5_Silent_p.T55T|UBC_ENST00000536661.1_5'UTR|UBC_ENST00000538617.1_Silent_p.T55T			P0CG48	UBC_HUMAN	ubiquitin C	55	Ubiquitin-like 1.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			breast(3)|endometrium(4)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.17e-05)|Epithelial(86;0.000207)|all cancers(50;0.00308)		AGTCAGACAGGGTGCGCCCAT	0.527000													80	143					0	0	0.323286	0	0
EPOR	2057	broad.mit.edu	37	19	11493829	11493829	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:11493829C>A	ENST00000592375.2	-	2	299	c.195G>T	c.(193-195)gaG>gaT	p.E65D	EPOR_ENST00000222139.6_Missense_Mutation_p.E65D			P19235	EPOR_HUMAN	erythropoietin receptor	65						extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			endometrium(1)|lung(2)|ovary(1)|urinary_tract(1)	5					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	TCGCCGCTTCCTCCCAGAAAC	0.687000													23	47					8.24728e-16	1.0421e-15	0.309145	1	0
CDH10	1008	broad.mit.edu	37	5	24491723	24491723	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:24491723G>T	ENST00000264463.4	-	11	2345	c.1838C>A	c.(1837-1839)gCc>gAc	p.A613D	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	613					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GGCGATCAAGGCCCCAGTGCT	0.498000										HNSCC(23;0.051)			38	119					2.00842e-17	2.58846e-17	0.290176	1	0
PRKCB	5579	broad.mit.edu	37	16	24196450	24196450	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:24196450T>A	ENST00000303531.7	+	14	1704	c.1552T>A	c.(1552-1554)Tat>Aat	p.Y518N	PRKCB_ENST00000321728.7_Missense_Mutation_p.Y518N	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	518	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	TTATCAGCCCTATGGGAAGTC	0.433000													69	11					0	0	0.323286	0	0
ZNF208	7757	broad.mit.edu	37	19	22155237	22155237	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:22155237C>A	ENST00000397126.4	-	4	2747	c.2599G>T	c.(2599-2601)Ggc>Tgc	p.G867C	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TAGGCTTTGCCACATTCTTCA	0.358000													103	64					3.00942e-58	5.23605e-58	0.323286	1	0
OFCC1	266553	broad.mit.edu	37	6	9908766	9908766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:9908766C>A	ENST00000316020.6	-	5	531	c.532G>T	c.(532-534)Gag>Tag	p.E178*	OFCC1_ENST00000472329.1_5'UTR					orofacial cleft 1 candidate 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|stomach(1)	11	Ovarian(93;0.0473)|Breast(50;0.201)	all_hematologic(90;0.124)				CTGCTGACCTCCGTCGCACAC	0.413000													119	92					1.02609e-67	1.81901e-67	0.323286	1	0
KRT72	140807	broad.mit.edu	37	12	52992774	52992774	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:52992774C>A	ENST00000293745.2	-	2	634	c.549G>T	c.(547-549)ctG>ctT	p.L183L	KRT72_ENST00000398066.3_5'UTR|KRT72_ENST00000354310.4_Silent_p.L183L|KRT72_ENST00000537672.2_Silent_p.L183L	NM_080747.2	NP_542785.1	Q14CN4	K2C72_HUMAN	keratin 72	183	Coil 1B.|Rod.					keratin filament	structural molecule activity	p.L183L(2)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(357;0.195)		GCTGCTTCTGCAGGTTGCTGA	0.537000													6	310					0.00198382	0.00204251	0.248553	1	0
DSC3	1825	broad.mit.edu	37	18	28598167	28598167	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:28598167A>G	ENST00000434452.1	-	9	1287	c.1133T>C	c.(1132-1134)aTa>aCa	p.I378T	DSC3_ENST00000360428.4_Missense_Mutation_p.I378T	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	378	Cadherin 3.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CTTATCTTCTATAGGTATTCG	0.294000													28	95					0	0	0.134883	0	0
LRP1B	53353	broad.mit.edu	37	2	141283910	141283910	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:141283910C>A	ENST00000389484.3	-	48	8743	c.7772G>T	c.(7771-7773)tGt>tTt	p.C2591F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2591	LDL-receptor class A 13.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AACCGTGGCACAGGTTGAAAC	0.373000										TSP Lung(27;0.18)			15	137					6.72482e-11	7.82373e-11	0.132662	1	0
TRPM2	7226	broad.mit.edu	37	21	45838357	45838357	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:45838357A>T	ENST00000397928.1	+	22	3825	c.3380A>T	c.(3379-3381)tAc>tTc	p.Y1127F	TRPM2_ENST00000300482.5_Missense_Mutation_p.Y1127F|TRPM2_ENST00000498430.1_3'UTR|TRPM2_ENST00000397932.2_Missense_Mutation_p.Y1127F|TRPM2_ENST00000300481.9_Missense_Mutation_p.Y1107F	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	1127						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						TGGGAGATCTACCTGAAGGAG	0.587000													31	3					0	0	0.153744	0	0
NINJ2	4815	broad.mit.edu	37	12	675315	675315	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:675315G>T	ENST00000305108.4	-	2	481	c.201C>A	c.(199-201)ccC>ccA	p.P67P	NINJ2_ENST00000537416.1_Intron|NINJ2_ENST00000397265.3_Silent_p.P14P|NINJ2_ENST00000433832.2_5'UTR|NINJ2_ENST00000542920.1_5'UTR	NM_016533.4	NP_057617.2	Q9NZG7	NINJ2_HUMAN	ninjurin 2	21					nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				large_intestine(3)|lung(1)|ovary(2)	6	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			TCAGGTTGATGGGCTGGCTCC	0.607000													18	61					1.55795e-14	1.93153e-14	0.234183	1	0
LINC01291	102724515	broad.mit.edu	37	2	75157621	75157621	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:75157621C>A	ENST00000377469.1	+	0	2256																											gggtgataatcaggcgcagga	0.552000													11	11					4.36969e-10	4.98818e-10	0.105934	1	0
COL19A1	1310	broad.mit.edu	37	6	70866215	70866215	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:70866215T>A	ENST00000322773.4	+	33	2294	c.2192T>A	c.(2191-2193)aTa>aAa	p.I731K	COL19A1_ENST00000393344.1_Missense_Mutation_p.I353K	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	731	Triple-helical region 4 (COL4).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TAGGGTGATATAGGGCCACGG	0.502000													98	53					0	0	0.323286	0	0
RBM4	5936	broad.mit.edu	37	11	66407690	66407690	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:66407690G>T	ENST00000483858.1	+	2	575	c.508G>T	c.(508-510)Gtt>Ttt	p.V170F	RBM14-RBM4_ENST00000500635.2_Intron|RBM4_ENST00000514361.3_Intron|RBM14-RBM4_ENST00000412278.2_Intron|RBM4_ENST00000506523.2_Intron|RBM4_ENST00000532968.1_Missense_Mutation_p.V170F|RBM4_ENST00000503028.2_Intron|RBM4_ENST00000310092.7_Intron|RBM4_ENST00000578778.1_Intron|RBM4_ENST00000530235.1_Intron|RBM4_ENST00000409406.1_Intron|RBM4_ENST00000398692.4_Intron|RBM4_ENST00000408993.2_Intron|RBM4_ENST00000396053.4_Intron					RNA binding motif protein 4											endometrium(3)|large_intestine(4)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13				Lung(977;0.0112)|LUSC - Lung squamous cell carcinoma(976;0.0266)		GATAACAGCTGTTGGCTGGCT	0.458000													15	8					6.49762e-13	7.81784e-13	0.175082	1	0
CCBL1	883	broad.mit.edu	37	9	131596097	131596097	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:131596097C>A	ENST00000436267.2	-	14	1562	c.1413G>T	c.(1411-1413)gtG>gtT	p.V471V	CCBL1_ENST00000320665.6_Silent_p.V327V|CCBL1_ENST00000483599.1_5'UTR|CCBL1_ENST00000302586.3_Silent_p.V377V			Q16773	KAT1_HUMAN	cysteine conjugate-beta lyase, cytoplasmic	377					kynurenine metabolic process|L-phenylalanine catabolic process|tryptophan catabolic process	cytosol|nucleus	1-aminocyclopropane-1-carboxylate synthase activity|cysteine-S-conjugate beta-lyase activity|glutamine-phenylpyruvate transaminase activity|kynurenine-oxoglutarate transaminase activity|L-glutamine:pyruvate aminotransferase activity|L-phenylalanine:pyruvate aminotransferase activity|protein homodimerization activity|pyridoxal phosphate binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(1)	18					L-Glutamine(DB00130)|Pyridoxal Phosphate(DB00114)	CAGGGATGGCCACCAAGCCCT	0.592000													13	12					1.05317e-09	1.19563e-09	0.119110	1	0
PPAN-P2RY11	692312	broad.mit.edu	37	19	10218681	10218681	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:10218681C>A	ENST00000428358.1	+	5	556	c.384C>A	c.(382-384)caC>caA	p.H128Q	PPAN-P2RY11_ENST00000393796.4_Missense_Mutation_p.H128Q|PPAN_ENST00000253107.7_Missense_Mutation_p.H128Q|PPAN_ENST00000393793.1_Missense_Mutation_p.H75Q|PPAN_ENST00000556468.1_Missense_Mutation_p.H128Q	NM_001040664.2|NM_001198690.1	NP_001035754.1|NP_001185619.1	Q9NQ55	SSF1_HUMAN		128	Brix.				RNA splicing	nucleolus	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	31			OV - Ovarian serous cystadenocarcinoma(20;2.19e-08)|Epithelial(33;1.76e-05)|all cancers(31;3.54e-05)			TGCGCCGGCACCGCATGCACG	0.607000													17	13					2.94398e-08	3.26208e-08	0.189662	1	0
PRAMEF11	440560	broad.mit.edu	37	1	12887606	12887606	+	Missense_Mutation	SNP	C	C	G	rs58074988		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:12887606C>G	ENST00000535591.1	-	3	446	c.251G>C	c.(250-252)tGc>tCc	p.C84S		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	84								p.C84S(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATTGAGGAAGCACCCATGGGC	0.483000													5	633					0	0	0.058154	0	0
ANKS6	203286	broad.mit.edu	37	9	101544820	101544820	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:101544820C>A	ENST00000353234.4	-	5	1195	c.1148G>T	c.(1147-1149)gGg>gTg	p.G383V	ANKS6_ENST00000540940.1_Missense_Mutation_p.G188V|ANKS6_ENST00000375018.1_Missense_Mutation_p.G383V|ANKS6_ENST00000375019.2_Missense_Mutation_p.G82V			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	383										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				GACATCGGCCCCTTGGTTTAG	0.433000													26	27					9.39395e-14	1.1472e-13	0.116897	1	0
RBM47	54502	broad.mit.edu	37	4	40438622	40438622	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:40438622C>T	ENST00000381793.2	-	4	1562	c.1166G>A	c.(1165-1167)aGa>aAa	p.R389K	RBM47_ENST00000319592.4_Intron|RBM47_ENST00000514014.1_Missense_Mutation_p.R351K|RBM47_ENST00000381795.6_Intron|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000295971.7_Missense_Mutation_p.R389K			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	389						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						CCCTGGGGCTCTGTTGCCAGC	0.522000													42	58					0	0	0.323286	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803939	23803939	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:23803939T>A	ENST00000264867.2	-	11	2168	c.2049A>T	c.(2047-2049)aaA>aaT	p.K683N	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	683	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				CAGGTCTGATTTTACCGACAT	0.507000													29	54					0	0	0.163468	0	0
ENPEP	2028	broad.mit.edu	37	4	111397573	111397573	+	Translation_Start_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:111397573G>T	ENST00000265162.5	+	1	345	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	1					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AAGCAAAAATGAACTTTGCGG	0.408000													47	31					1.22102e-19	1.62226e-19	0.323286	1	0
SHB	6461	broad.mit.edu	37	9	37974622	37974622	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:37974622C>A	ENST00000377707.3	-	3	1616	c.1051G>T	c.(1051-1053)Gca>Tca	p.A351S	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	351	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		TCCTTACCTGCCAGGGCTGGG	0.652000													61	63					2.23399e-28	3.28211e-28	0.323286	1	0
SPARC	6678	broad.mit.edu	37	5	151046005	151046005	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:151046005G>T	ENST00000231061.4	-	8	964	c.651C>A	c.(649-651)gcC>gcA	p.A217A	SPARC_ENST00000537849.1_5'UTR	NM_003118.3	NP_003109.1	P09486	SPRC_HUMAN	secreted protein, acidic, cysteine-rich (osteonectin)	217					ossification|platelet activation|platelet degranulation|signal transduction	basement membrane|extracellular space|platelet alpha granule lumen	calcium ion binding|collagen binding			central_nervous_system(3)|large_intestine(5)|lung(5)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(196;0.109)|all_hematologic(541;0.122)	Kidney(363;0.000171)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)	OV - Ovarian serous cystadenocarcinoma(192;0.00118)	Becaplermin(DB00102)	CGAAGTCCCGGGCCAGCAGCT	0.567000													29	28					5.60225e-13	6.75629e-13	0.144211	1	0
SDK2	54549	broad.mit.edu	37	17	71410867	71410867	+	Silent	SNP	C	C	T	rs139471859		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:71410867C>T	ENST00000392650.3	-	18	2400	c.2400G>A	c.(2398-2400)gcG>gcA	p.A800A	SDK2_ENST00000388726.3_Silent_p.A800A	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	800	Fibronectin type-III 3.				cell adhesion	integral to membrane		p.A800A(1)		breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						TGGTGGCTTCCGCGTGCACAT	0.602000													15	36					0	0	0.119110	0	0
ITGA5	3678	broad.mit.edu	37	12	54793518	54793518	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:54793518T>A	ENST00000293379.4	-	27	3013	c.2752A>T	c.(2752-2754)Agg>Tgg	p.R918W	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	918					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						CAGCGCAGCCTGAAACACTCA	0.552000											OREG0021897	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	109	60					0	0	0.323286	0	0
GATA3	2625	broad.mit.edu	37	10	8100536	8100536	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:8100536A>T	ENST00000379328.3	+	3	1078	c.510A>T	c.(508-510)ccA>ccT	p.P170P	GATA3_ENST00000461472.1_3'UTR|GATA3_ENST00000346208.3_Silent_p.P170P	NM_001002295.1|NM_002051.2	NP_001002295.1|NP_002042.1	P23771	GATA3_HUMAN	GATA binding protein 3	170					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			NS(1)|breast(44)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(24)|ovary(3)|skin(2)	87						TGTCCACCCCAGGCTCGGCCG	0.701000			"""F, N, S"""		breast		"""HDR syndrome (HYPOPARATHYROIDISM, SENSORINEURAL DEAFNESS, AND RENAL DISEASE)"""						12	23					0	0	0.214465	0	0
FNDC3B	64778	broad.mit.edu	37	3	172052793	172052793	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:172052793G>A	ENST00000336824.4	+	15	1800	c.1701G>A	c.(1699-1701)acG>acA	p.T567T	FNDC3B_ENST00000415807.2_Silent_p.T567T|FNDC3B_ENST00000416957.1_Silent_p.T567T	NM_001135095.1	NP_001128567.1	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	567						endoplasmic reticulum|integral to membrane		p.T567T(1)		breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(12)|lung(26)|ovary(3)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	69	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TTTGTACGACGAGTCCTGACA	0.463000													70	150					0	0	0.323286	0	0
SPC25	57405	broad.mit.edu	37	2	169732593	169732593	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:169732593C>A	ENST00000282074.2	-	5	581	c.440G>T	c.(439-441)cGa>cTa	p.R147L		NM_020675.3	NP_065726.1	Q9HBM1	SPC25_HUMAN	SPC25, NDC80 kinetochore complex component	147	Interaction with the C-terminus of SPBC24.				cell division|chromosome segregation|mitotic prometaphase|mitotic spindle organization	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	9						ATAAATTTTTCGAATTTCTAG	0.284000													14	29					2.32078e-09	2.61839e-09	0.132662	1	0
NOX5	79400	broad.mit.edu	37	15	69347677	69347677	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:69347677G>T	ENST00000260364.5	+	16	2250	c.1949G>T	c.(1948-1950)cGc>cTc	p.R650L	NOX5_ENST00000448182.3_Missense_Mutation_p.R622L|NOX5_ENST00000388866.3_Missense_Mutation_p.R668L|NOX5_ENST00000530406.2_Missense_Mutation_p.R640L|NOX5_ENST00000455873.3_Missense_Mutation_p.R633L			Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	668					angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35						CCAACAGGCCGCTTCCTGGAG	0.587000													40	76					1.06522e-23	1.49682e-23	0.312237	1	0
OR2B3	442184	broad.mit.edu	37	6	29054325	29054325	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:29054325C>A	ENST00000377173.2	-	1	765	c.701G>T	c.(700-702)cGg>cTg	p.R234L		NM_001005226.2	NP_001005226.1			olfactory receptor, family 2, subfamily B, member 3											breast(1)|endometrium(1)|kidney(2)|lung(17)|prostate(1)|skin(2)	24						TGCTTTTTGCCGTCCTTCTGC	0.413000													52	31					1.17673e-23	1.65276e-23	0.323286	1	0
KCNJ3	3760	broad.mit.edu	37	2	155711649	155711649	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:155711649C>A	ENST00000295101.2	+	3	1807	c.1330C>A	c.(1330-1332)Ccg>Acg	p.P444T		NM_001260509.1|NM_002239.3	NP_001247438.1|NP_002230.1	P48549	IRK3_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 3	444					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding	p.P444S(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(9)|lung(30)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	54					Halothane(DB01159)	AAGTTCAGTTCCGGGCAACTC	0.423000													94	168					1.73998e-50	2.93503e-50	0.323286	1	0
NRAP	4892	broad.mit.edu	37	10	115365556	115365556	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:115365556G>T	ENST00000369358.4	-	34	4148	c.3904C>A	c.(3904-3906)Cag>Aag	p.Q1302K	NRAP_ENST00000360478.3_Missense_Mutation_p.Q1259K|NRAP_ENST00000359988.3_Missense_Mutation_p.Q1294K|NRAP_ENST00000369360.3_Missense_Mutation_p.Q1267K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1294						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CGGGCAGCCTGGAAGGGGAGC	0.443000													126	121					2.79522e-57	4.84974e-57	0.323286	1	0
COL4A6	1288	broad.mit.edu	37	X	107408244	107408244	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:107408244G>T	ENST00000334504.7	-	39	4066	c.3833C>A	c.(3832-3834)cCa>cAa	p.P1278Q	COL4A6_ENST00000538570.1_Missense_Mutation_p.P1254Q|COL4A6_ENST00000372216.4_Missense_Mutation_p.P1279Q|COL4A6_ENST00000545689.1_Missense_Mutation_p.P1254Q|COL4A6_ENST00000394872.2_Missense_Mutation_p.P1279Q	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	1279	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						AGGGGGACCTGGGGGTCCAGC	0.622000									Alport syndrome with Diffuse Leiomyomatosis				32	3					6.29468e-14	7.71759e-14	0.214465	1	0
SEMA6D	80031	broad.mit.edu	37	15	48058162	48058162	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:48058162C>T	ENST00000316364.5	+	14	1963	c.1524C>T	c.(1522-1524)atC>atT	p.I508I	SEMA6D_ENST00000389428.3_Silent_p.I508I|SEMA6D_ENST00000358066.4_Silent_p.I508I|SEMA6D_ENST00000355997.3_Silent_p.I508I|SEMA6D_ENST00000558816.1_Silent_p.I508I|SEMA6D_ENST00000354744.4_Silent_p.I508I|SEMA6D_ENST00000389433.2_Silent_p.I508I|SEMA6D_ENST00000537942.1_Silent_p.I508I|SEMA6D_ENST00000536845.2_Silent_p.I508I|SEMA6D_ENST00000558014.1_Silent_p.I508I|SEMA6D_ENST00000389432.2_Silent_p.I508I	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	508	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GCTGCATTATCCGCATCCCCC	0.438000													99	82					0	0	0.323286	0	0
TRPC6	7225	broad.mit.edu	37	11	101374827	101374827	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:101374827T>A	ENST00000344327.3	-	2	1297	c.873A>T	c.(871-873)gaA>gaT	p.E291D	TRPC6_ENST00000360497.4_Missense_Mutation_p.E291D|TRPC6_ENST00000532133.1_Missense_Mutation_p.E291D|TRPC6_ENST00000348423.4_Missense_Mutation_p.E291D	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	291					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		TGACTGGATCTTCACTAGACA	0.448000													171	144					0	0	0.323286	0	0
INVS	27130	broad.mit.edu	37	9	102888679	102888679	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:102888679A>G	ENST00000262457.2	+	3	306	c.121A>G	c.(121-123)Aaa>Gaa	p.K41E	INVS_ENST00000374921.3_Missense_Mutation_p.K41E|INVS_ENST00000460636.2_3'UTR|INVS_ENST00000262456.2_Missense_Mutation_p.K41E|INVS_ENST00000541287.1_5'UTR	NM_014425.3	NP_055240.2	Q9Y283	INVS_HUMAN	inversin	41					negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Acute lymphoblastic leukemia(62;0.056)				CTCTGCTCTTAAAGACAAAGA	0.358000													25	22					0	0	0.279207	0	0
SYNE1	23345	broad.mit.edu	37	6	152765658	152765658	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:152765658T>G	ENST00000367255.5	-	30	4326	c.3725A>C	c.(3724-3726)aAa>aCa	p.K1242T	SYNE1_ENST00000448038.1_Missense_Mutation_p.K1249T|SYNE1_ENST00000265368.4_Missense_Mutation_p.K1242T|SYNE1_ENST00000367248.3_Missense_Mutation_p.K1232T|SYNE1_ENST00000423061.1_Missense_Mutation_p.K1249T|SYNE1_ENST00000367253.4_Missense_Mutation_p.K1242T|SYNE1_ENST00000341594.5_Missense_Mutation_p.K1308T|SYNE1_ENST00000413186.2_Missense_Mutation_p.K1242T	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1242					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GAGAGAATTTTTGACTATTTC	0.338000										HNSCC(10;0.0054)			25	58					0	0	0.279207	0	0
ADCK2	90956	broad.mit.edu	37	7	140386893	140386893	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:140386893C>A	ENST00000072869.4	+	5	1587	c.1409C>A	c.(1408-1410)gCg>gAg	p.A470E	ADCK2_ENST00000476491.1_Missense_Mutation_p.A470E	NM_052853.3	NP_443085.2	Q7Z695	ADCK2_HUMAN	aarF domain containing kinase 2	470	Protein kinase.					integral to membrane	ATP binding|protein serine/threonine kinase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|skin(4)	15	Melanoma(164;0.00956)					CTGCAGCAGGCGGACATCTGT	0.612000													3	65					0.115264	0.116734	0.115264	1	0
NRBP1	29959	broad.mit.edu	37	2	27656155	27656155	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:27656155G>C	ENST00000233557.3	+	3	847	c.15G>C	c.(13-15)gaG>gaC	p.E5D	NRBP1_ENST00000379852.3_Missense_Mutation_p.E5D|NRBP1_ENST00000379863.3_Missense_Mutation_p.E5D			Q9UHY1	NRBP_HUMAN	nuclear receptor binding protein 1	5					ER to Golgi vesicle-mediated transport|gene expression|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cell cortex|endomembrane system|lamellipodium|membrane|nucleoplasm	ATP binding|protein homodimerization activity|protein kinase activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	Acute lymphoblastic leukemia(172;0.155)					CGGAGGGGGAGTCCCAGACAG	0.517000													16	29					0	0	0.189662	0	0
ITIH6	347365	broad.mit.edu	37	X	54817493	54817493	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:54817493G>T	ENST00000218436.6	-	4	422	c.393C>A	c.(391-393)cgC>cgA	p.R131R		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	131	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TGGTGGAGATGCGGAACTTCT	0.582000													15	25					7.05477e-17	9.03956e-17	0.160694	1	0
WDR62	284403	broad.mit.edu	37	19	36590381	36590381	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:36590381G>T	ENST00000401500.2	+	22	2636	c.2601G>T	c.(2599-2601)cgG>cgT	p.R867R	WDR62_ENST00000270301.7_Silent_p.R867R	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	867					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGGCAGAGCGGGCCGGCCAAG	0.602000													66	87					6.20995e-33	9.56827e-33	0.323286	1	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74835217	74835217	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:74835217A>T	ENST00000370895.1	+	18	1953	c.1918A>T	c.(1918-1920)Act>Tct	p.T640S	RP11-439H8.4_ENST00000415549.2_RNA|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.T640S|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.T640S|TNNI3K_ENST00000326637.3_Missense_Mutation_p.T539S|TNNI3K_ENST00000370891.2_Missense_Mutation_p.T640S			Q59H18	TNI3K_HUMAN		539	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										TGCCATTGTCACTCAATACAT	0.463000													123	144					0	0	0.323286	0	0
HLA-C	3107	broad.mit.edu	37	6	31238994	31238994	+	Missense_Mutation	SNP	C	C	A	rs41562518		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31238994C>A	ENST00000383329.3	-	3	489	c.475G>T	c.(475-477)Gcc>Tcc	p.A159S	HLA-C_ENST00000376228.5_Missense_Mutation_p.A159S			Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	159	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	17						GTGTCCGCGGCGGTCCAGGAG	0.701000													4	36					9.70103e-10	1.10294e-09	0.069234	1	0
ZDHHC22	283576	broad.mit.edu	37	14	77605928	77605928	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:77605928C>A	ENST00000319374.4	-	2	356	c.154G>T	c.(154-156)Gcg>Tcg	p.A52S	RP11-463C8.4_ENST00000557752.1_Intron	NM_174976.2	NP_777636.2	Q8N966	ZDH22_HUMAN	zinc finger, DHHC-type containing 22	52						integral to membrane	acyltransferase activity|zinc ion binding			kidney(1)|lung(1)|urinary_tract(1)	3			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0277)		AGGAAGAGCGCCCCGTGGAGC	0.687000											OREG0022834	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	9					9.31168e-06	9.94423e-06	0.105934	1	0
KAT7	11143	broad.mit.edu	37	17	47895246	47895246	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:47895246G>T	ENST00000503935.2	+	9	1596	c.560G>T	c.(559-561)gGc>gTc	p.G187V	KAT7_ENST00000513980.1_Intron|KAT7_ENST00000259021.4_Missense_Mutation_p.G343V|KAT7_ENST00000509773.1_Missense_Mutation_p.G233V|KAT7_ENST00000510819.1_Missense_Mutation_p.G174V|KAT7_ENST00000454930.2_Missense_Mutation_p.G204V|KAT7_ENST00000424009.2_Missense_Mutation_p.G313V|KAT7_ENST00000435742.2_Missense_Mutation_p.G157V			O95251	MYST2_HUMAN	K(lysine) acetyltransferase 7	343					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										ATTGCTTTTGGCCGCTATGAG	0.403000													44	112					1.23103e-26	1.77656e-26	0.312237	1	0
IGSF21	84966	broad.mit.edu	37	1	18688691	18688691	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:18688691C>A	ENST00000251296.1	+	5	890	c.507C>A	c.(505-507)gtC>gtA	p.V169V		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	169						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		TCACGCTGGTCTGCATCGTGT	0.612000													13	14					7.93312e-07	8.60556e-07	0.119110	1	0
HSF2BP	11077	broad.mit.edu	37	21	45033781	45033781	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:45033781G>T	ENST00000291560.2	-	7	953	c.622C>A	c.(622-624)Cgg>Agg	p.R208R	HSF2BP_ENST00000542962.1_Silent_p.R133R	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	208					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		AAGAGCACCCGGCTTGAATTA	0.403000													33	58					5.43694e-19	7.17435e-19	0.225048	1	0
KIAA1614	57710	broad.mit.edu	37	1	180885637	180885637	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:180885637C>A	ENST00000367588.4	+	2	453	c.398C>A	c.(397-399)tCt>tAt	p.S133Y		NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	133										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						TCAGAGGGGTCTTTCCTGCCA	0.617000													19	31					2.89027e-11	3.38931e-11	0.249174	1	0
GRID2	2895	broad.mit.edu	37	4	94376904	94376904	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:94376904G>A	ENST00000282020.4	+	11	1895	c.1637G>A	c.(1636-1638)gGg>gAg	p.G546E	GRID2_ENST00000510992.1_Missense_Mutation_p.G451E	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	546					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	TACTCAGTGGGGGTACTACTT	0.468000													72	39					0	0	0.323286	0	0
SPON2	10417	broad.mit.edu	37	4	1165197	1165197	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:1165197G>T	ENST00000290902.5	-	3	630	c.298C>A	c.(298-300)Cgc>Agc	p.R100S	SPON2_ENST00000431380.1_Missense_Mutation_p.R100S	NM_012445.3	NP_036577.1	Q9BUD6	SPON2_HUMAN	spondin 2, extracellular matrix protein	100	Spondin.				axon guidance|cell adhesion|innate immune response	proteinaceous extracellular matrix	metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|pancreas(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(23;0.00805)	UCEC - Uterine corpus endometrioid carcinoma (64;0.139)|Colorectal(103;0.19)		GCCTCGCCGCGCTCCGCAAAG	0.706000													4	15					0.00909568	0.00927843	0.150653	1	0
PSG2	5670	broad.mit.edu	37	19	43575865	43575865	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:43575865T>C	ENST00000406487.1	-	4	1049	c.951A>G	c.(949-951)acA>acG	p.T317T		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	317	Ig-like C2-type 2.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				AGACTTTGACTGTCAACGATG	0.448000													63	264					0	0	0.323286	0	0
TGM5	9333	broad.mit.edu	37	15	43533162	43533162	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:43533162G>C	ENST00000220420.5	-	7	896	c.889C>G	c.(889-891)Cgt>Ggt	p.R297G	TGM5_ENST00000349114.4_Missense_Mutation_p.R215G	NM_201631.3	NP_963925.2	O43548	TGM5_HUMAN	transglutaminase 5	297					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(11)|lung(15)|skin(6)|urinary_tract(1)	44		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	GTGATCACACGGGTAGGGATC	0.473000													38	50					0	0	0.268233	0	0
MYO6	4646	broad.mit.edu	37	6	76624644	76624644	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:76624644G>T	ENST00000369981.3	+	35	4055	c.3776G>T	c.(3775-3777)gGc>gTc	p.G1259V	MYO6_ENST00000369977.3_Missense_Mutation_p.G1258V|MYO6_ENST00000369975.1_Missense_Mutation_p.G1226V|MYO6_ENST00000369985.4_Missense_Mutation_p.G1235V			Q9UM54	MYO6_HUMAN	myosin VI	1267					actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		CGCTGTGGAGGCATCCAGTAC	0.522000													21	46					9.90768e-06	1.05771e-05	0.309145	1	0
PDE3B	5140	broad.mit.edu	37	11	14856571	14856571	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:14856571G>T	ENST00000282096.4	+	11	2603	c.2250G>T	c.(2248-2250)tgG>tgT	p.W750C	PDE3B_ENST00000455098.2_Missense_Mutation_p.W699C	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	750	Catalytic (By similarity).				cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						ATGCAGTTTGGTATCTGACAA	0.383000													50	71					1.27334e-21	1.73953e-21	0.323286	1	0
CDH2	1000	broad.mit.edu	37	18	25532211	25532211	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:25532211G>T	ENST00000269141.3	-	16	3050	c.2627C>A	c.(2626-2628)tCa>tAa	p.S876*	CDH2_ENST00000399380.3_Nonsense_Mutation_p.S845*	NM_001792.3	NP_001783.2	P19022	CADH2_HUMAN	cadherin 2, type 1, N-cadherin (neuronal)	876	Ser-rich.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			NS(1)|breast(5)|cervix(2)|endometrium(7)|kidney(3)|large_intestine(22)|lung(32)|ovary(4)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ACCACTACTTGAGGAATTAAG	0.507000											OREG0003876	type=REGULATORY REGION|Gene=CDH2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	204	94					3.03857e-81	5.46483e-81	0.323286	1	0
KMT2C	58508	broad.mit.edu	37	7	151845739	151845739	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:151845739C>A	ENST00000355193.2	-	53	13662	c.13444G>T	c.(13444-13446)Gat>Tat	p.D4482Y	KMT2C_ENST00000262189.6_Missense_Mutation_p.D4425Y					lysine (K)-specific methyltransferase 2C																		ACCCACAGATCCAAGTCAAGG	0.502000													71	130					4.75426e-39	7.62898e-39	0.323286	1	0
TTN	7273	broad.mit.edu	37	2	179472330	179472330	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179472330C>T	ENST00000589042.1	-	277	53309	c.53085G>A	c.(53083-53085)gtG>gtA	p.V17695V	TTN_ENST00000342175.6_Silent_p.V8822V|TTN_ENST00000359218.5_Silent_p.V8755V|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Silent_p.V16054V|TTN_ENST00000460472.2_Silent_p.V8630V|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Silent_p.V15127V|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000589907.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16054	Fibronectin type-III 28.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACCAGTCACCACAGCTGGAA	0.458000													173	519					0	0	0.323286	0	0
TDRD3	81550	broad.mit.edu	37	13	61103100	61103100	+	Missense_Mutation	SNP	A	A	T	rs151029002		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:61103100A>T	ENST00000196169.3	+	11	2250	c.1462A>T	c.(1462-1464)Aat>Tat	p.N488Y	TDRD3_ENST00000377881.2_Missense_Mutation_p.N488Y|TDRD3_ENST00000535286.1_Missense_Mutation_p.N581Y|TDRD3_ENST00000377894.2_Missense_Mutation_p.N488Y	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	488					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity	p.N488D(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		AGTTCGAAGTAATAGTTTCAT	0.358000													21	23					0	0	0.234183	0	0
CTNND2	1501	broad.mit.edu	37	5	11159704	11159704	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:11159704C>G	ENST00000304623.8	-	12	2332	c.2143G>C	c.(2143-2145)Gcc>Ccc	p.A715P	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Missense_Mutation_p.A378P|CTNND2_ENST00000511377.1_Missense_Mutation_p.A624P|CTNND2_ENST00000359640.2_Missense_Mutation_p.A715P|CTNND2_ENST00000458100.2_Missense_Mutation_p.A282P	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	715					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						CACCCGGTGGCGTTACGCAGC	0.532000													124	135					0	0	0.323286	0	0
LMO7	4008	broad.mit.edu	37	13	76393660	76393660	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:76393660G>T	ENST00000357063.3	+	14	3612	c.2352G>T	c.(2350-2352)atG>atT	p.M784I	LMO7_ENST00000377534.3_Missense_Mutation_p.M784I|LMO7_ENST00000465261.2_Missense_Mutation_p.M499I|LMO7_ENST00000341547.4_Missense_Mutation_p.M450I|LMO7_ENST00000321797.8_Missense_Mutation_p.M499I|LMO7_ENST00000526202.1_Missense_Mutation_p.M349I			Q8WWI1	LMO7_HUMAN	LIM domain 7	784						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TTAAGGAAATGCTGCAGGACA	0.388000													64	88					3.37205e-40	5.4477e-40	0.323286	1	0
ITFG1	81533	broad.mit.edu	37	16	47294486	47294486	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:47294486C>G	ENST00000320640.6	-	11	1419	c.1191G>C	c.(1189-1191)atG>atC	p.M397I	ITFG1_ENST00000544001.2_Missense_Mutation_p.M284I|ITFG1_ENST00000568047.1_5'UTR	NM_030790.3	NP_110417.2	Q8TB96	TIP_HUMAN	integrin alpha FG-GAP repeat containing 1	397						extracellular region|integral to membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	19		all_cancers(37;0.0613)|all_lung(18;0.0543)|Lung NSC(13;0.227)				AGGTGGCAACCATGGCATCCT	0.433000													50	10					0	0	0.323286	0	0
SH3GL3	6457	broad.mit.edu	37	15	84257444	84257444	+	Silent	SNP	A	A	T	rs140124071		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:84257444A>T	ENST00000324537.5	+	11	1275	c.783A>T	c.(781-783)cgA>cgT	p.R261R	SH3GL3_ENST00000427482.2_Silent_p.R253R|SH3GL3_ENST00000535412.1_Silent_p.R253R|SH3GL3_ENST00000434347.1_Silent_p.R261R			Q99963	SH3G3_HUMAN	SH3-domain GRB2-like 3	253					central nervous system development|endocytosis|signal transduction	early endosome membrane	identical protein binding|lipid binding			central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	30						TCCCCAGACGAGAATACAAGC	0.453000													8	123					0	0	0.058154	0	0
ANKRD17	26057	broad.mit.edu	37	4	74005688	74005688	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:74005688T>G	ENST00000358602.4	-	15	2761	c.2645A>C	c.(2644-2646)cAg>cCg	p.Q882P	ANKRD17_ENST00000509867.2_Missense_Mutation_p.Q769P|ANKRD17_ENST00000514252.1_5'UTR|ANKRD17_ENST00000330838.6_Intron	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	882	Gln-rich.				interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TTTTAGCTGCTGCTGAGTTTT	0.403000													92	23					0	0	0.323286	0	0
MMRN1	22915	broad.mit.edu	37	4	90830523	90830523	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:90830523G>T	ENST00000394980.1	+	3	1039	c.720G>T	c.(718-720)tgG>tgT	p.W240C	MMRN1_ENST00000394981.1_Missense_Mutation_p.W206C|MMRN1_ENST00000264790.2_Missense_Mutation_p.W240C|MMRN1_ENST00000508372.1_5'UTR			Q13201	MMRN1_HUMAN	multimerin 1	240	EMI.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CTTGTGGCTGGACCGGTGGAT	0.413000													41	21					9.84934e-19	1.29252e-18	0.290176	1	0
TDRD5	163589	broad.mit.edu	37	1	179562685	179562685	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:179562685G>T	ENST00000444136.1	+	3	573	c.323G>T	c.(322-324)aGa>aTa	p.R108I	TDRD5_ENST00000367614.1_Missense_Mutation_p.R108I|TDRD5_ENST00000294848.8_Missense_Mutation_p.R108I	NM_001199085.1|NM_001199089.1	NP_001186014.1|NP_001186018.1	Q8NAT2	TDRD5_HUMAN	tudor domain containing 5	108					DNA methylation involved in gamete generation|P granule organization|spermatid development	chromatoid body|pi-body	nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(7)|lung(44)|ovary(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)	77						CATAAGGGAAGACCTAGTATT	0.468000													53	42					1.44317e-28	2.12631e-28	0.323286	1	0
DAB2	1601	broad.mit.edu	37	5	39377118	39377118	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:39377118C>A	ENST00000545653.1	-	11	2238	c.1708G>T	c.(1708-1710)Ggg>Tgg	p.G570W	DAB2_ENST00000339788.6_Missense_Mutation_p.G373W|DAB2_ENST00000509337.1_Missense_Mutation_p.G570W|DAB2_ENST00000320816.6_Missense_Mutation_p.G591W	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	591					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			AAAGGATTCCCCAAAGGGCTT	0.567000											OREG0016586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	83	187					2.56221e-42	4.17861e-42	0.323286	1	0
TACR2	6865	broad.mit.edu	37	10	71164609	71164609	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:71164609G>T	ENST00000373306.4	-	5	1713	c.1170C>A	c.(1168-1170)gcC>gcA	p.A390A	TACR2_ENST00000373307.1_Silent_p.A178A	NM_001057.2	NP_001048.2	P21452	NK2R_HUMAN	tachykinin receptor 2	390					excretion|muscle contraction	integral to plasma membrane	tachykinin receptor activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	11					Clonidine(DB00575)|Octreotide(DB00104)	ttttggtgggggcaagcaaac	0.557000													7	6					0.00448238	0.00460582	0.307466	1	0
SNX19	399979	broad.mit.edu	37	11	130773244	130773244	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:130773244G>C	ENST00000265909.4	-	8	3048	c.2479C>G	c.(2479-2481)Ctg>Gtg	p.L827V	SNX19_ENST00000533318.1_5'UTR|SNX19_ENST00000545537.1_Missense_Mutation_p.L67V|SNX19_ENST00000528555.1_Missense_Mutation_p.L207V|SNX19_ENST00000539184.1_Missense_Mutation_p.L270V|SNX19_ENST00000534726.1_Missense_Mutation_p.L67V|SNX19_ENST00000530356.1_Missense_Mutation_p.L207V	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	827					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		AAGAGGAGCAGATCCAGGGCT	0.438000													40	97					0	0	0.268233	0	0
KRT6B	3854	broad.mit.edu	37	12	52844334	52844334	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:52844334T>G	ENST00000252252.3	-	2	658	c.611A>C	c.(610-612)aAg>aCg	p.K204T		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	204	Linker 1.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		CCTCACAGTCTTGGTGCCCTG	0.572000													17	187					0	0	0.264190	0	0
ADCY4	196883	broad.mit.edu	37	14	24798698	24798698	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:24798698C>A	ENST00000310677.4	-	10	1372	c.1259G>T	c.(1258-1260)gGg>gTg	p.G420V	ADCY4_ENST00000418030.2_Missense_Mutation_p.G420V|ADCY4_ENST00000554068.2_Missense_Mutation_p.G420V|ADCY4_ENST00000396747.3_Missense_Mutation_p.G113V	NM_001198568.1|NM_001198592.1|NM_139247.3	NP_001185497.1|NP_001185521.1|NP_640340.2	Q8NFM4	ADCY4_HUMAN	adenylate cyclase 4	420					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding|protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(265;0.0192)		AGCATAAGCCCCTGCCAGCAG	0.612000													27	39					9.8876e-21	1.33603e-20	0.214465	1	0
EPO	2056	broad.mit.edu	37	7	100319630	100319630	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100319630C>A	ENST00000252723.2	+	3	386	c.205C>A	c.(205-207)Cca>Aca	p.P69T		NM_000799.2	NP_000790.2	P01588	EPO_HUMAN	erythropoietin	69					blood circulation|cellular hyperosmotic response|erythrocyte maturation|negative regulation of apoptosis|negative regulation of ion transmembrane transporter activity|negative regulation of sodium ion transport|positive regulation of cell proliferation|positive regulation of DNA replication|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat5 protein|signal transduction	extracellular space	erythropoietin receptor binding|eukaryotic cell surface binding|hormone activity			central_nervous_system(2)|endometrium(2)|lung(7)|prostate(1)	12	Lung NSC(181;0.041)|all_lung(186;0.0581)				Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	TATCACTGTCCCAGACACCAA	0.483000													48	49					8.04919e-23	1.11786e-22	0.323286	1	0
ATG9A	79065	broad.mit.edu	37	2	220085570	220085570	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220085570G>C	ENST00000409618.1	-	15	2852	c.2413C>G	c.(2413-2415)Cct>Gct	p.P805A	ATG9A_ENST00000396761.2_Missense_Mutation_p.P805A|ATG9A_ENST00000361242.4_Missense_Mutation_p.P805A|ATG9A_ENST00000409422.1_Missense_Mutation_p.P744A			Q7Z3C6	ATG9A_HUMAN	autophagy related 9A	805					autophagic vacuole assembly|protein transport	autophagic vacuole membrane|cytoplasmic vesicle|Golgi apparatus|integral to membrane|late endosome membrane				endometrium(2)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(1)	13		Renal(207;0.0474)		Epithelial(149;1.37e-06)|all cancers(144;0.000222)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTCCAAGAGGCAGCCGAGAG	0.567000													9	21					0	0	0.105934	0	0
PKLR	5313	broad.mit.edu	37	1	155265545	155265545	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:155265545G>A	ENST00000392414.3	-	3	306	c.193C>T	c.(193-195)Cca>Tca	p.P65S	PKLR_ENST00000342741.4_Missense_Mutation_p.P96S	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	96					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CGAGATGCTGGCCCTAGAACC	0.582000													34	151					0	0	0.225048	0	0
GPR64	10149	broad.mit.edu	37	X	19027766	19027766	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:19027766G>T	ENST00000379878.3	-	17	1593	c.1352C>A	c.(1351-1353)gCc>gAc	p.A451D	GPR64_ENST00000357991.3_Missense_Mutation_p.A464D|GPR64_ENST00000340581.3_Missense_Mutation_p.A437D|GPR64_ENST00000379873.2_Missense_Mutation_p.A467D|GPR64_ENST00000379876.1_Missense_Mutation_p.A443D|GPR64_ENST00000356606.4_Missense_Mutation_p.A453D|GPR64_ENST00000379869.3_Missense_Mutation_p.A467D|GPR64_ENST00000360279.4_Missense_Mutation_p.A445D|GPR64_ENST00000357544.3_Missense_Mutation_p.A437D|GPR64_ENST00000354791.3_Missense_Mutation_p.A451D	NM_001184833.1	NP_001171762.1	Q8IZP9	GPR64_HUMAN	G protein-coupled receptor 64	467					neuropeptide signaling pathway|spermatogenesis	cytoplasm|integral to plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(18)|stomach(1)|urinary_tract(1)	42	Hepatocellular(33;0.183)					AGGGTCTTGGGCCACAAAGGT	0.418000													58	67					6.2918e-36	9.8862e-36	0.323286	1	0
ROBO3	64221	broad.mit.edu	37	11	124740532	124740532	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:124740532G>A	ENST00000397801.1	+	6	1133	c.941G>A	c.(940-942)gGg>gAg	p.G314E	ROBO3_ENST00000538940.1_Missense_Mutation_p.G292E	NM_022370.3	NP_071765.2	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3 (Drosophila)	314	Ig-like C2-type 3.				axon midline choice point recognition	integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	35	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		CTTTGGATTGGGCATGTGAGT	0.607000													6	36					0	0	0.278610	0	0
HVCN1	84329	broad.mit.edu	37	12	111099189	111099189	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:111099189G>A	ENST00000356742.5	-	3	839	c.86C>T	c.(85-87)aCg>aTg	p.T29M	HVCN1_ENST00000439744.2_Missense_Mutation_p.T9M|HVCN1_ENST00000242607.8_Missense_Mutation_p.T29M|HVCN1_ENST00000548312.1_Missense_Mutation_p.T29M			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	29					response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						TCCCACGACCGTGAAGTGCCT	0.577000													31	34					0	0	0.144211	0	0
DGKB	1607	broad.mit.edu	37	7	14722442	14722442	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:14722442C>A	ENST00000403951.2	-	11	1273	c.854G>T	c.(853-855)cGc>cTc	p.R285L	DGKB_ENST00000402815.1_Missense_Mutation_p.R285L|DGKB_ENST00000407950.1_Missense_Mutation_p.R278L|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000444700.2_Missense_Mutation_p.R278L|DGKB_ENST00000399322.3_Missense_Mutation_p.R285L|DGKB_ENST00000258767.5_Missense_Mutation_p.R285L|DGKB_ENST00000406247.3_Missense_Mutation_p.R285L			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	285					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	AGCCACACAGCGCTCATGGAC	0.443000													19	24					1.77063e-15	2.22822e-15	0.324025	1	0
OR4C12	283093	broad.mit.edu	37	11	50003863	50003863	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:50003863A>C	ENST00000335238.4	-	1	208	c.175T>G	c.(175-177)Ttc>Gtc	p.F59V		NM_001005270.2	NP_001005270.1	Q96R67	OR4CC_HUMAN	olfactory receptor, family 4, subfamily C, member 12	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(4)|large_intestine(3)|liver(1)|lung(19)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	36						GTCAGGAAGAAGTACATGGGG	0.413000													49	208					0	0	0.323286	0	0
CSMD1	64478	broad.mit.edu	37	8	3045485	3045485	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:3045485G>T	ENST00000520002.1	-	37	6084	c.5529C>A	c.(5527-5529)atC>atA	p.I1843I	CSMD1_ENST00000542608.1_Silent_p.I1842I|CSMD1_ENST00000539096.1_Silent_p.I1842I|CSMD1_ENST00000537824.1_Silent_p.I1842I|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000602723.1_Silent_p.I1843I|CSMD1_ENST00000400186.3_Silent_p.I1843I|CSMD1_ENST00000602557.1_Silent_p.I1843I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1843	CUB 11.			IQVISFATEQNWDSL -> DPSDQFCHGAELGLPF (in Ref. 1; AAK73475/AAG52948).		integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGATCACTTGGATCTACCAAA	0.423000													17	2					2.37509e-13	2.88344e-13	0.219247	1	0
FAM135B	51059	broad.mit.edu	37	8	139255306	139255306	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:139255306G>T	ENST00000395297.1	-	7	718	c.548C>A	c.(547-549)aCt>aAt	p.T183N		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	183										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TCCTGGACGAGTAAAACTAAA	0.453000										HNSCC(54;0.14)			28	37					2.08457e-15	2.62116e-15	0.153744	1	0
OR2G3	81469	broad.mit.edu	37	1	247769303	247769303	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247769303G>T	ENST00000320002.2	+	1	448	c.416G>T	c.(415-417)cGg>cTg	p.R139L	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	139					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			ATGAACCCACGGCTTTGCCAA	0.507000													346	124					2.59523e-182	4.82439e-182	0.323286	1	0
DCHS2	54798	broad.mit.edu	37	4	155180878	155180878	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:155180878A>G	ENST00000357232.3	-	20	5242	c.5243T>C	c.(5242-5244)cTt>cCt	p.L1748P		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1748	Cadherin 15.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		TTCAAAATCAAGAAACTTGGG	0.318000													33	17					0	0	0.214465	0	0
SLC3A2	6520	broad.mit.edu	37	11	62656036	62656036	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:62656036C>T	ENST00000377892.1	+	13	2081	c.1857C>T	c.(1855-1857)agC>agT	p.S619S	SLC3A2_ENST00000377890.2_Silent_p.S588S|SLC3A2_ENST00000536981.1_Silent_p.S133S|SLC3A2_ENST00000535296.1_Silent_p.S557S|SLC3A2_ENST00000338663.7_Silent_p.S487S|SLC3A2_ENST00000377889.2_Silent_p.S526S|SLC3A2_ENST00000377891.2_Silent_p.S589S			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	588					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						CCAGCGCCAGCCTGCCAGCCA	0.642000													18	23					0	0	0.153744	0	0
MYH6	4624	broad.mit.edu	37	14	23858206	23858206	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:23858206C>G	ENST00000405093.3	-	29	4107	c.4037G>C	c.(4036-4038)cGg>cCg	p.R1346P	MYH6_ENST00000356287.3_Missense_Mutation_p.R1346P	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1346					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		GTACTGCTCCCGCAGCAGGTC	0.682000													31	46					0	0	0.203993	0	0
CPS1	1373	broad.mit.edu	37	2	211527882	211527882	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:211527882T>A	ENST00000233072.5	+	33	4159	c.3963T>A	c.(3961-3963)gcT>gcA	p.A1321A	CPS1_ENST00000451903.2_Silent_p.A870A|CPS1_ENST00000430249.2_Silent_p.A1327A	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1321					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGAGGGATGCTGACCCCATTC	0.388000													19	259					0	0	0.249174	0	0
ABCA13	154664	broad.mit.edu	37	7	48311973	48311973	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:48311973G>T	ENST00000435803.1	+	17	2734	c.2710G>T	c.(2710-2712)Gaa>Taa	p.E904*		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	904					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TAGTCTCCATGAATTTGGATT	0.393000													83	85					7.83748e-43	1.28223e-42	0.323286	1	0
PSMD1	5707	broad.mit.edu	37	2	231947621	231947621	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:231947621G>T	ENST00000308696.6	+	13	1600	c.1438G>T	c.(1438-1440)Ggc>Tgc	p.G480C	PSMD1_ENST00000409643.1_Missense_Mutation_p.G480C|PSMD1_ENST00000373635.4_Missense_Mutation_p.G480C	NM_002807.3	NP_002798.2	Q99460	PSMD1_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	480					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)	31		Ovarian(221;0.000626)|Medulloblastoma(418;0.0109)|Renal(207;0.0112)|Lung NSC(271;0.0538)|all_lung(227;0.0713)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;4e-26)|LUSC - Lung squamous cell carcinoma(224;0.0138)|Lung(119;0.0168)	Bortezomib(DB00188)	TGGCAGTCTGGGCCTTGGTTT	0.368000													20	31					1.66031e-10	1.91436e-10	0.294199	1	0
COQ5	84274	broad.mit.edu	37	12	120960118	120960118	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:120960118T>C	ENST00000288532.6	-	2	291	c.251A>G	c.(250-252)gAt>gGt	p.D84G	COQ5_ENST00000445328.2_Missense_Mutation_p.D84G	NM_032314.3	NP_115690.3	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase (S. cerevisiae)	84					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(1)|prostate(1)|urinary_tract(3)	20	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACTCATCATATCATTCATCAC	0.448000													19	26					0	0	0.249174	0	0
ROS1	6098	broad.mit.edu	37	6	117609876	117609876	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:117609876T>A	ENST00000368508.3	-	43	7021	c.6823A>T	c.(6823-6825)Atg>Ttg	p.M2275L	ROS1_ENST00000368507.3_Missense_Mutation_p.M2269L	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2275					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GCAAGTACCATATAGTTTAAC	0.423000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								43	66					0	0	0.268233	0	0
FAM83C	128876	broad.mit.edu	37	20	33874655	33874655	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:33874655G>T	ENST00000374408.3	-	4	2023	c.1927C>A	c.(1927-1929)Cca>Aca	p.P643T		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	643										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCACGGAATGGGCCGAACTTT	0.637000													17	66					5.3912e-06	5.77536e-06	0.175082	1	0
CFHR3	10878	broad.mit.edu	37	1	196749059	196749059	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:196749059G>A	ENST00000471440.2	+	3	460	c.386G>A	c.(385-387)tGt>tAt	p.C129Y	CFHR3_ENST00000391985.3_Missense_Mutation_p.C129Y|CFHR3_ENST00000367425.4_Missense_Mutation_p.C129Y					complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						ACAGTTACATGTACGGAGAAA	0.463000													62	164					0	0	0.323286	0	0
HEY2	23493	broad.mit.edu	37	6	126080920	126080920	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:126080920C>A	ENST00000368364.3	+	5	1183	c.986C>A	c.(985-987)cCc>cAc	p.P329H	HEY2_ENST00000368365.1_Missense_Mutation_p.P283H	NM_012259.2	NP_036391.1	Q9UBP5	HEY2_HUMAN	hes-related family bHLH transcription factor with YRPW motif 2	329					negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription initiation from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|Notch signaling pathway|smooth muscle cell differentiation|transcription, DNA-dependent	transcriptional repressor complex	histone deacetylase binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding			breast(1)|large_intestine(7)|lung(5)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (4;0.0608)|GBM - Glioblastoma multiforme(226;0.0361)|all cancers(137;0.193)		CCTTACCGACCCTGGGGGACA	0.502000													44	84					8.04919e-23	1.11786e-22	0.323286	1	0
PPP1R1A	5502	broad.mit.edu	37	12	54976577	54976577	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:54976577G>A	ENST00000257905.8	-	4	356	c.186C>T	c.(184-186)tcC>tcT	p.S62S	PPP1R1A_ENST00000547431.1_Intron	NM_006741.3	NP_006732.3	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1A	62					glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			lung(2)	2						TTGCCAAAGTGGACTGTGAAG	0.597000													73	207					0	0	0.323286	0	0
ZNF611	81856	broad.mit.edu	37	19	53210019	53210019	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:53210019G>C	ENST00000543227.1	-	6	563	c.289C>G	c.(289-291)Cac>Gac	p.H97D	ZNF611_ENST00000540744.1_Missense_Mutation_p.H97D|ZNF611_ENST00000453741.2_Missense_Mutation_p.H28D|ZNF611_ENST00000602162.1_Missense_Mutation_p.H28D|ZNF611_ENST00000600943.1_3'UTR|ZNF611_ENST00000595798.1_Missense_Mutation_p.H28D|ZNF611_ENST00000319783.1_Missense_Mutation_p.H97D	NM_001161499.1	NP_001154971.1	Q8N823	ZN611_HUMAN	zinc finger protein 611	97	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		TCTCCAATGTGATGACTTTCA	0.408000													127	311					0	0	0.323286	0	0
PSG9	5678	broad.mit.edu	37	19	43762592	43762592	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:43762592G>T	ENST00000244293.7	-	4	792	c.726C>A	c.(724-726)ccC>ccA	p.P242P	PSG9_ENST00000291752.5_Silent_p.P149P|PSG9_ENST00000270077.3_Silent_p.P335P|PSG9_ENST00000418820.2_Silent_p.P242P|PSG9_ENST00000443718.3_Silent_p.P242P|PSG9_ENST00000593948.1_Silent_p.P242P|PSG9_ENST00000596730.1_Silent_p.P149P			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	240	Ig-like C2-type 2.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				GGTAAATTCTGGGGAGGTCTG	0.478000													241	37					1.63485e-142	3.02637e-142	0.323286	1	0
EMILIN3	90187	broad.mit.edu	37	20	39991417	39991417	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:39991417G>C	ENST00000332312.3	-	4	984	c.792C>G	c.(790-792)acC>acG	p.T264T		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	264						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				GCTGCACCTTGGTCTGAAGAG	0.617000													22	109					0	0	0.294199	0	0
ABCA8	10351	broad.mit.edu	37	17	66883268	66883268	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:66883268G>T	ENST00000269080.2	-	24	3336	c.3199C>A	c.(3199-3201)Cca>Aca	p.P1067T	ABCA8_ENST00000430352.2_Missense_Mutation_p.P1107T|ABCA8_ENST00000586539.1_Missense_Mutation_p.P1107T	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	1067						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					ACAGCACATGGGATCTAAAAT	0.353000													38	27					2.45108e-15	3.06831e-15	0.268233	1	0
VARS	7407	broad.mit.edu	37	6	31759427	31759427	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31759427G>C	ENST00000375663.3	-	8	1500	c.1060C>G	c.(1060-1062)Cat>Gat	p.H354D	VARS_ENST00000444930.2_Missense_Mutation_p.H59D	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	354					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GTGAGTGCATGGCCCAGGTGC	0.567000													32	62					0	0	0.163468	0	0
NLRP13	126204	broad.mit.edu	37	19	56424480	56424480	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:56424480C>G	ENST00000588751.1	-	5	727	c.703G>C	c.(703-705)Ggg>Cgg	p.G235R	NLRP13_ENST00000342929.3_Missense_Mutation_p.G235R			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	235	NACHT.						ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		CCTGCCCTCCCCACCAAGACT	0.502000													136	14					0	0	0.323286	0	0
ITGAV	3685	broad.mit.edu	37	2	187455108	187455108	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:187455108G>T	ENST00000261023.3	+	1	317	c.43G>T	c.(43-45)Ggc>Tgc	p.G15C	ITGAV_ENST00000374907.3_Missense_Mutation_p.G15C	NM_002210.3	NP_002201.1	P06756	ITAV_HUMAN	integrin, alpha V	15					angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	47			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		CGGTCCCCGCGGCCTCCCGCT	0.701000													35	33					4.01765e-15	5.01721e-15	0.279185	1	0
PLEC	5339	broad.mit.edu	37	8	144991466	144991466	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:144991466C>G	ENST00000322810.4	-	32	13103	c.12934G>C	c.(12934-12936)Gag>Cag	p.E4312Q	PLEC_ENST00000357649.2_Missense_Mutation_p.E4179Q|PLEC_ENST00000398774.2_Missense_Mutation_p.E4143Q|PLEC_ENST00000356346.3_Missense_Mutation_p.E4161Q|PLEC_ENST00000354958.2_Missense_Mutation_p.E4153Q|PLEC_ENST00000345136.3_Missense_Mutation_p.E4175Q|PLEC_ENST00000354589.3_Missense_Mutation_p.E4175Q|PLEC_ENST00000527096.1_Missense_Mutation_p.E4198Q|PLEC_ENST00000436759.2_Missense_Mutation_p.E4202Q	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4312	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CACTCGCACTCCTGCTCGGAC	0.622000													17	19					0	0	0.264190	0	0
ADA	100	broad.mit.edu	37	20	43255112	43255112	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:43255112G>T	ENST00000372874.4	-	4	481	c.347C>A	c.(346-348)cCc>cAc	p.P116H	ADA_ENST00000464097.1_5'UTR|ADA_ENST00000537820.1_Missense_Mutation_p.P116H	NM_000022.2	NP_000013.2	P00813	ADA_HUMAN	adenosine deaminase	116					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(2)|prostate(3)|skin(2)|urinary_tract(1)	18		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	CTGGTTCCAGGGGATTGGCTC	0.592000									Adenosine Deaminase Deficiency				42	74					1.67886e-27	2.44564e-27	0.323286	1	0
MDC1	9656	broad.mit.edu	37	6	30679651	30679651	+	Splice_Site	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:30679651C>G	ENST00000376406.3	-	5	2715	c.2068_splice	c.e5+1	p.D690_splice	MDC1_ENST00000494654.1_5'UTR|MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Splice_Site_p.D690_splice	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	690				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CAGCACTTACCACCATAGTTG	0.517000								Other conserved DNA damage response genes					23	276					0	0	0.294199	0	0
PPAP2C	8612	broad.mit.edu	37	19	282141	282141	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:282141G>A	ENST00000269812.3	-	5	759	c.710C>T	c.(709-711)gCc>gTc	p.A237V	PPAP2C_ENST00000434325.2_Missense_Mutation_p.A181V|PPAP2C_ENST00000327790.3_Missense_Mutation_p.A258V	NM_003712.2|NM_177526.1	NP_003703.1|NP_803545.1	O43688	LPP2_HUMAN	phosphatidic acid phosphatase type 2C	237					sphingolipid metabolic process	integral to membrane|plasma membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(1)|lung(1)|skin(1)	5		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACAGTGAGGGCAGCCACCAG	0.597000													14	12					0	0	0.160694	0	0
KRT32	3882	broad.mit.edu	37	17	39619273	39619273	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39619273C>G	ENST00000225899.3	-	6	1129	c.1026G>C	c.(1024-1026)gaG>gaC	p.E342D		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	342	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				GGGCCTCACTCTCCGTCAGCG	0.572000													6	42					0	0	0.058154	0	0
LEP	3952	broad.mit.edu	37	7	127894641	127894641	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:127894641T>G	ENST00000308868.4	+	3	380	c.329T>G	c.(328-330)gTg>gGg	p.V110G		NM_000230.2	NP_000221.1	P41159	LEP_HUMAN	leptin	110			V -> M (in dbSNP:rs1800564).		adult feeding behavior|energy reserve metabolic process|negative regulation of appetite|placenta development|positive regulation of developmental growth	extracellular space				endometrium(1)|large_intestine(2)|lung(5)	8						CTTCTTCACGTGCTGGCCTTC	0.567000													31	118					0	0	0.163468	0	0
NOD1	10392	broad.mit.edu	37	7	30490947	30490947	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:30490947A>G	ENST00000222823.4	-	6	2611	c.2086T>C	c.(2086-2088)Tcc>Ccc	p.S696P		NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	696					activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						AGGACGAAGGAGAGGGCGCTG	0.637000													15	63					0	0	0.175082	0	0
KIAA1462	57608	broad.mit.edu	37	10	30336463	30336463	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:30336463C>A	ENST00000375377.1	-	2	380	c.279G>T	c.(277-279)gcG>gcT	p.A93A		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	93										breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						AAACTTACCCCGCCTCCGAGG	0.562000													28	94					3.86903e-22	5.33261e-22	0.173368	1	0
ZNF852	285346	broad.mit.edu	37	3	44541041	44541041	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:44541041G>T	ENST00000436261.1	-	4	1388	c.1228C>A	c.(1228-1230)Ccc>Acc	p.P410T	ZNF852_ENST00000489411.1_5'UTR			B6EU87	B6EU87_HUMAN	zinc finger protein 852	410					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)	8						CATTTATAGGGCTTTTCACTT	0.393000													4	96					0.00909568	0.00927843	0.150653	1	0
OR10K2	391107	broad.mit.edu	37	1	158390136	158390136	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158390136A>T	ENST00000314902.2	-	1	520	c.521T>A	c.(520-522)cTa>cAa	p.L174Q		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					GAAGTGATGTAGTTGATTGGA	0.463000													118	230					0	0	0.323286	0	0
ROBO4	54538	broad.mit.edu	37	11	124767670	124767670	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:124767670G>T	ENST00000306534.3	-	1	507	c.22C>A	c.(22-24)Ctc>Atc	p.L8I	ROBO4_ENST00000533054.1_5'UTR|ROBO4_ENST00000526899.1_Intron	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	8					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CCCCCCAGGAGGCTGTCTCCT	0.617000													10	21					4.84862e-15	6.04759e-15	0.080935	1	0
OR5AC2	81050	broad.mit.edu	37	3	97806572	97806572	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:97806572C>T	ENST00000358642.2	+	1	556	c.556C>T	c.(556-558)Ctg>Ttg	p.L186L		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						AATTTTACAACTGTTCAAAAT	0.313000													81	72					0	0	0.323286	0	0
REM1	28954	broad.mit.edu	37	20	30070222	30070222	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:30070222G>T	ENST00000201979.2	+	4	849	c.556G>T	c.(556-558)Gac>Tac	p.D186Y		NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	186					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			ACATCAGGCAGACCATGTGCC	0.607000													36	53					1.57945e-13	1.92506e-13	0.301197	1	0
KDR	3791	broad.mit.edu	37	4	55963918	55963918	+	Missense_Mutation	SNP	C	C	A	rs149901681		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:55963918C>A	ENST00000263923.4	-	18	2820	c.2525G>T	c.(2524-2526)cGt>cTt	p.R842L		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	842	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AAAGGCACCACGGCCAAGAGG	0.428000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			61	117					1.88225e-35	2.95007e-35	0.323286	1	0
KCNAB1	7881	broad.mit.edu	37	3	156009877	156009877	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:156009877C>T	ENST00000302490.8	+	1	1052	c.181C>T	c.(181-183)Ctc>Ttc	p.L61F	KCNAB1_ENST00000389636.5_Intron|KCNAB1_ENST00000490337.1_Intron|KCNAB1_ENST00000389634.5_Missense_Mutation_p.L61F|KCNAB1_ENST00000471742.1_Intron	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	79						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TCACATTTCTCTCAAAGAGTC	0.562000													17	56					0	0	0.204396	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517482	158517482	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158517482T>C	ENST00000302617.3	-	1	413	c.414A>G	c.(412-414)ccA>ccG	p.P138P		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					TCATGATGACTGGGTAGCGTA	0.453000													60	100					0	0	0.323286	0	0
VPS13B	157680	broad.mit.edu	37	8	100587926	100587926	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:100587926G>T	ENST00000358544.2	+	32	5176	c.5065G>T	c.(5065-5067)Gtt>Ttt	p.V1689F	VPS13B_ENST00000357162.2_Missense_Mutation_p.V1664F|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1689					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTTGACCCCCGTTTTGACAGA	0.353000													52	67					2.41709e-19	3.20451e-19	0.323286	1	0
ZNF98	148198	broad.mit.edu	37	19	22575654	22575654	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:22575654C>A	ENST00000357774.5	-	4	504	c.383G>T	c.(382-384)aGc>aTc	p.S128I		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CTCATCCATGCTTTTACAGTA	0.318000													18	62					3.32936e-07	3.6332e-07	0.175082	1	0
SCN3A	6328	broad.mit.edu	37	2	165986775	165986775	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:165986775G>T	ENST00000360093.3	-	17	3088	c.2597C>A	c.(2596-2598)cCc>cAc	p.P866H	SCN3A_ENST00000283254.7_Missense_Mutation_p.P866H|SCN3A_ENST00000409101.3_Missense_Mutation_p.P817H	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	866						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ATTTAGTGTGGGCCAGGATTT	0.363000													15	188					2.32078e-09	2.61839e-09	0.132662	1	0
SCAF8	22828	broad.mit.edu	37	6	155153580	155153580	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:155153580C>T	ENST00000367178.3	+	20	3443	c.2867C>T	c.(2866-2868)tCg>tTg	p.S956L	SCAF8_ENST00000417268.1_Missense_Mutation_p.S956L|SCAF8_ENST00000367186.4_Missense_Mutation_p.S1022L	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	956	Pro-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						CCACCCCCATCGGTACTTGAT	0.493000													142	358					0	0	0.323286	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857036	19857036	+	RNA	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:19857036A>G	ENST00000548109.1	+	0	72																											CTGGATAATAAAGTTCATCTC	0.373000													4	160					0	0	0.150653	0	0
PACSIN3	29763	broad.mit.edu	37	11	47203976	47203976	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:47203976C>A	ENST00000539589.1	-	4	531	c.189G>T	c.(187-189)aaG>aaT	p.K63N	PACSIN3_ENST00000298838.6_Missense_Mutation_p.K63N	NM_001184975.1	NP_001171904.1	Q9UKS6	PACN3_HUMAN	protein kinase C and casein kinase substrate in neurons 3	63	FCH.				endocytosis|negative regulation of endocytosis|positive regulation of membrane protein ectodomain proteolysis	cytoplasm|plasma membrane	cytoskeletal protein binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)	11						TCCCCCTCCACTTTCGGGCCC	0.667000													25	39					2.08973e-25	2.98657e-25	0.324025	1	0
PDHX	8050	broad.mit.edu	37	11	34988231	34988231	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:34988231C>A	ENST00000448838.3	+	6	883	c.641C>A	c.(640-642)aCc>aAc	p.T214N	PDHX_ENST00000430469.2_Intron|PDHX_ENST00000227868.4_Missense_Mutation_p.T229N	NM_001135024.1|NM_003477.2	NP_001128496.1|NP_003468.2	O00330	ODPX_HUMAN	pyruvate dehydrogenase complex, component X	229	Interaction with DLD.				pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	16	all_epithelial(35;0.115)|Lung NSC(22;0.218)|all_lung(20;0.242)	all_hematologic(20;0.124)	STAD - Stomach adenocarcinoma(6;0.00113)			GGCAAGATTACCGAGTCCAGA	0.502000													93	445					3.84403e-29	5.68799e-29	0.323286	1	0
CHD6	84181	broad.mit.edu	37	20	40049655	40049655	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:40049655C>A	ENST00000373233.3	-	31	5797	c.5620G>T	c.(5620-5622)Gag>Tag	p.E1874*		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1874	Poly-Glu.				chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				ttttcctcctcgttttcctcc	0.428000													81	106					1.68136e-41	2.7277e-41	0.323286	1	0
ZCCHC11	23318	broad.mit.edu	37	1	52903977	52903977	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:52903977C>T	ENST00000371544.3	-	25	4115	c.3853G>A	c.(3853-3855)Gat>Aat	p.D1285N	ZCCHC11_ENST00000257177.4_Missense_Mutation_p.D1285N	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	1285					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						AGTTCTCCATCTGTTAATACT	0.388000													45	103					0	0	0.323286	0	0
HEPHL1	341208	broad.mit.edu	37	11	93803634	93803634	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:93803634T>A	ENST00000315765.9	+	6	1166	c.1158T>A	c.(1156-1158)gcT>gcA	p.A386A		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	386	Plastocyanin-like 3.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TTATAGCAGCTGAAAAAATTC	0.433000													15	34					0	0	0.189662	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153847407	153847407	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:153847407A>G	ENST00000356448.4	+	4	1452	c.1168A>G	c.(1168-1170)Att>Gtt	p.I390V	ARHGEF26_ENST00000465093.1_Missense_Mutation_p.I390V|ARHGEF26_ENST00000465817.1_Missense_Mutation_p.I390V	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	390					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						GGCCCTTGACATTGATTCTGA	0.398000													26	40					0	0	0.116897	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174982	207174982	+	Silent	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:207174982A>C	ENST00000374423.3	+	5	6116	c.5730A>C	c.(5728-5730)tcA>tcC	p.S1910S		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1910							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ATGACTTGTCAGTGGCCTTAG	0.498000													47	172					0	0	0.323286	0	0
MCTP1	79772	broad.mit.edu	37	5	94046621	94046621	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:94046621C>A	ENST00000515393.1	-	21	2731	c.2732G>T	c.(2731-2733)tGg>tTg	p.W911L	MCTP1_ENST00000312216.8_Missense_Mutation_p.W690L|MCTP1_ENST00000505078.1_Missense_Mutation_p.W427L|MCTP1_ENST00000429576.2_Missense_Mutation_p.W604L|MCTP1_ENST00000514040.1_5'UTR|ANKRD32_ENST00000493934.1_Intron	NM_024717.4	NP_078993.4	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1	911					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(3)|large_intestine(13)|liver(2)|lung(13)|ovary(2)|skin(4)|stomach(2)|urinary_tract(1)	41		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		TGGGACAGTCCAGTTGAAAGT	0.408000													22	21					4.54149e-19	5.99786e-19	0.249174	1	0
RIMS1	22999	broad.mit.edu	37	6	72806711	72806711	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:72806711C>T	ENST00000264839.7	+	3	305	c.305C>T	c.(304-306)gCg>gTg	p.A102V	RIMS1_ENST00000517960.1_Missense_Mutation_p.A102V|RIMS1_ENST00000491071.2_Missense_Mutation_p.A102V|RIMS1_ENST00000522291.1_Missense_Mutation_p.A102V|RIMS1_ENST00000520567.1_Missense_Mutation_p.A102V|RIMS1_ENST00000521978.1_Missense_Mutation_p.A102V|RIMS1_ENST00000348717.5_Missense_Mutation_p.A102V|RIMS1_ENST00000518273.1_Missense_Mutation_p.A102V			Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	102	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(25)|liver(4)|lung(35)|ovary(9)|pancreas(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	102		all_epithelial(107;0.179)|all_hematologic(105;0.212)				GGGGAAGAAGCGCGGCGTTAC	0.438000													32	20					0	0	0.214465	0	0
OR10V1	390201	broad.mit.edu	37	11	59481232	59481232	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:59481232C>A	ENST00000307552.2	-	1	105	c.87G>T	c.(85-87)gtG>gtT	p.V29V	STX3_ENST00000300150.7_5'UTR	NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						TCAGGAAGACCACAAAAATCA	0.433000													25	85					1.42536e-11	1.67909e-11	0.309145	1	0
ATP10D	57205	broad.mit.edu	37	4	47563059	47563059	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:47563059G>T	ENST00000273859.3	+	14	2904	c.2635G>T	c.(2635-2637)Gcc>Tcc	p.A879S		NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	879					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						ACTTGAATCTGCCATGAGGTT	0.388000													67	136					6.12789e-21	8.3055e-21	0.323286	1	0
UBE3C	9690	broad.mit.edu	37	7	157023956	157023956	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:157023956G>T	ENST00000348165.5	+	18	2776	c.2416G>T	c.(2416-2418)Gct>Tct	p.A806S		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	806	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		CAACCCGGCTGCTCAGATGCT	0.423000													18	68					7.07596e-05	7.4589e-05	0.175082	1	0
UBBP4	23666	broad.mit.edu	37	17	21731043	21731043	+	Silent	SNP	C	C	T	rs112378881		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:21731043C>T	ENST00000584755.1	+	2	742	c.345C>T	c.(343-345)gaC>gaT	p.D115D	UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Silent_p.D115D																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						TCCCCCCCGACCAGCAGAGGC	0.552000													4	74					0	0	0.150653	0	0
CMTM1	113540	broad.mit.edu	37	16	66612743	66612743	+	Missense_Mutation	SNP	C	C	G	rs150823211		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:66612743C>G	ENST00000379500.2	+	4	767	c.700C>G	c.(700-702)Ctc>Gtc	p.L234V	CMTM1_ENST00000533666.1_Intron|CMTM1_ENST00000332695.7_Missense_Mutation_p.L70V|CMTM1_ENST00000328020.6_Intron|CMTM1_ENST00000528324.1_Intron|CMTM1_ENST00000531885.1_Intron|CKLF-CMTM1_ENST00000527729.1_Missense_Mutation_p.L63V|CMTM1_ENST00000336328.6_Missense_Mutation_p.L64V|CMTM1_ENST00000457188.2_Missense_Mutation_p.L117V|CMTM1_ENST00000533953.1_Missense_Mutation_p.L186V	NM_052999.3|NM_181268.2	NP_443725.3|NP_851785.2	Q8IZ96	CKLF1_HUMAN	CKLF-like MARVEL transmembrane domain containing 1	117					chemotaxis	extracellular space|integral to membrane	cytokine activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	7		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0702)|Epithelial(162;0.222)		GTCCCTGTGTCTCACAGCGGT	0.498000													6	57					0	0	0.217242	0	0
PTAR1	375743	broad.mit.edu	37	9	72347217	72347217	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:72347217C>G	ENST00000377200.5	-	3	245	c.243G>C	c.(241-243)gtG>gtC	p.V81V	PTAR1_ENST00000340434.4_Silent_p.V160V			Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat containing 1	160					protein prenylation		protein prenyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)	5						TTCCTTTGGTCACAAAGGAAG	0.483000													49	73					0	0	0.323286	0	0
DOCK10	55619	broad.mit.edu	37	2	225638018	225638018	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:225638018G>T	ENST00000409592.3	-	53	6155	c.6042C>A	c.(6040-6042)agC>agA	p.S2014R	DOCK10_ENST00000258390.7_Missense_Mutation_p.S2020R			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	2020	DHR-2.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TGCTCGATTGGCTAATTACTT	0.423000													62	122					2.02796e-37	3.22081e-37	0.323286	1	0
TTC26	79989	broad.mit.edu	37	7	138849886	138849886	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:138849886C>T	ENST00000464848.1	+	9	881	c.801C>T	c.(799-801)ttC>ttT	p.F267F	TTC26_ENST00000481482.1_3'UTR|TTC26_ENST00000430935.1_Silent_p.F267F|TTC26_ENST00000495038.1_Silent_p.F136F|TTC26_ENST00000478836.2_Silent_p.F161F|TTC26_ENST00000343187.4_Silent_p.F236F			A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26	267							binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	24						AGGTTGTTTTCCGAGGAGGTG	0.403000													27	36					0	0	0.144211	0	0
EPHA3	2042	broad.mit.edu	37	3	89391202	89391202	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:89391202G>A	ENST00000336596.2	+	5	1493	c.1268G>A	c.(1267-1269)aGa>aAa	p.R423K	EPHA3_ENST00000452448.2_Missense_Mutation_p.R423K|EPHA3_ENST00000494014.1_Missense_Mutation_p.R423K	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	423	Fibronectin type-III 1.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TCCCCACCAAGACAGTTTGCT	0.468000										TSP Lung(6;0.00050)			43	80					0	0	0.323286	0	0
FOLH1B	219595	broad.mit.edu	37	11	89403576	89403576	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:89403576C>A	ENST00000532352.1	+	0	927							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						AGATGCACATCCACTCTACCA	0.348000													27	61					9.39395e-14	1.1472e-13	0.116897	1	0
SLC19A3	80704	broad.mit.edu	37	2	228564016	228564016	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:228564016C>T	ENST00000258403.3	-	3	486	c.415G>A	c.(415-417)Gtg>Atg	p.V139M	SLC19A3_ENST00000541617.1_Missense_Mutation_p.V135M|SLC19A3_ENST00000409287.1_Intron	NM_025243.3	NP_079519.1	Q9BZV2	S19A3_HUMAN	solute carrier family 19 (thiamine transporter), member 3	139					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|skin(3)	30		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	TAGCCGCTCACTCTCTGGTAG	0.582000													24	54					0	0	0.268233	0	0
GFRAL	389400	broad.mit.edu	37	6	55264237	55264237	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:55264237T>C	ENST00000340465.2	+	8	1205	c.1119T>C	c.(1117-1119)ctT>ctC	p.L373L		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	373						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TGGTCAAGCTTAGGTAACTGA	0.383000													24	72					0	0	0.144211	0	0
C15orf26	161502	broad.mit.edu	37	15	81440257	81440257	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:81440257G>T	ENST00000286732.4	+	6	778	c.695G>T	c.(694-696)cGg>cTg	p.R232L		NM_173528.2	NP_775799.2	Q6P656	CO026_HUMAN	chromosome 15 open reading frame 26	232								p.R232Q(1)		endometrium(1)|kidney(4)|large_intestine(5)|lung(6)|skin(1)	17						GCAGCCCACCGGCATCTTTTC	0.388000													9	28					7.03913e-09	7.85309e-09	0.093190	1	0
ACVR1C	130399	broad.mit.edu	37	2	158406903	158406903	+	Splice_Site	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:158406903A>G	ENST00000243349.7	-	4	906	c.544_splice	c.e4-1	p.G182_splice	ACVR1C_ENST00000409680.3_Splice_Site_p.G132_splice|ACVR1C_ENST00000348328.5_Intron|ACVR1C_ENST00000335450.7_Splice_Site_p.G102_splice	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	182	GS.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						ACAGAGGTAGACCTAACCAAA	0.353000													28	92					0	0	0.134883	0	0
SCN10A	6336	broad.mit.edu	37	3	38739454	38739454	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:38739454G>T	ENST00000449082.2	-	27	5256	c.5257C>A	c.(5257-5259)Cca>Aca	p.P1753T		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1753					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	GTGGCCTCTGGGTCAAACTTC	0.488000													95	211					5.40725e-42	8.79992e-42	0.323286	1	0
TSHB	7252	broad.mit.edu	37	1	115576687	115576687	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:115576687G>C	ENST00000256592.1	+	3	324	c.256G>C	c.(256-258)Gga>Cga	p.G86R	TSHB_ENST00000369517.1_Missense_Mutation_p.G86R	NM_000549.3|NM_001277991.1	NP_000540.2|NP_001264920.1	P01222	TSHB_HUMAN	thyroid stimulating hormone, beta	86					anatomical structure morphogenesis|cell-cell signaling|cellular nitrogen compound metabolic process|G-protein coupled receptor protein signaling pathway|hormone biosynthetic process|peptide hormone processing	extracellular region	hormone activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	Lung SC(450;0.211)	all_cancers(81;3.22e-07)|all_epithelial(167;1.4e-06)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)		AGAAATACCAGGATGCCCACT	0.433000													59	395					0	0	0.323286	0	0
OR5D13	390142	broad.mit.edu	37	11	55541412	55541412	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55541412G>T	ENST00000361760.1	+	1	499	c.499G>T	c.(499-501)Gac>Tac	p.D167Y		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	167					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TTTTCTTCTTGACTTATCGTT	0.423000													84	200					2.43516e-34	3.78599e-34	0.323286	1	0
PRRC2A	7916	broad.mit.edu	37	6	31604645	31604645	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31604645C>T	ENST00000376033.2	+	28	6304	c.6070C>T	c.(6070-6072)Cgg>Tgg	p.R2024W	PRRC2A_ENST00000376007.4_Missense_Mutation_p.R2024W	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	2024	3 X 50 AA type C repeats.					cytoplasm|nucleus	protein binding	p.R2024W(1)		breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CCTGGCTGTGCGGCCCCCACC	0.672000													4	156					0	0	0.150653	0	0
GPR98	84059	broad.mit.edu	37	5	90020682	90020682	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:90020682G>A	ENST00000405460.2	+	46	9878	c.9782G>A	c.(9781-9783)aGt>aAt	p.S3261N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3261					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GTATTTCAAAGTTTTTTGGAT	0.303000													41	249					0	0	0.323286	0	0
C7orf63	79846	broad.mit.edu	37	7	89900878	89900878	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:89900878G>C	ENST00000389297.4	+	7	822	c.571G>C	c.(571-573)Gct>Cct	p.A191P	C7orf63_ENST00000463311.1_3'UTR|C7orf63_ENST00000497910.1_Missense_Mutation_p.A173P|C7orf63_ENST00000316089.8_Missense_Mutation_p.A191P	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	191							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						GATTCAAATGGCTGAAGTTGG	0.353000													49	158					0	0	0.323286	0	0
NRXN1	9378	broad.mit.edu	37	2	50758552	50758552	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:50758552G>T	ENST00000404971.1	-	12	3619	c.2280C>A	c.(2278-2280)agC>agA	p.S760R	NRXN1_ENST00000402717.3_Missense_Mutation_p.S712R|NRXN1_ENST00000406316.2_Missense_Mutation_p.S720R|NRXN1_ENST00000405472.3_Missense_Mutation_p.S712R|NRXN1_ENST00000401669.2_Missense_Mutation_p.S720R|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406859.3_Missense_Mutation_p.S720R	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	720	Laminin G-like 4.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TCCCATCATAGCTCAAAACCG	0.413000													20	20					8.34094e-07	9.04161e-07	0.204396	1	0
TAL1	6886	broad.mit.edu	37	1	47685837	47685837	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:47685837G>T	ENST00000371883.3	-	4	1133	c.557C>A	c.(556-558)aCc>aAc	p.T186N	TAL1_ENST00000294339.3_Missense_Mutation_p.T184N|TAL1_ENST00000371884.2_Missense_Mutation_p.T184N|TAL1_ENST00000459729.1_5'UTR			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	184					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						CACAACTTTGGTGTGGGGACC	0.552000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								34	20					6.29468e-14	7.71759e-14	0.214465	1	0
PDK3	5165	broad.mit.edu	37	X	24546235	24546235	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:24546235C>A	ENST00000441463.2	+	9	895	c.895C>A	c.(895-897)Cgt>Agt	p.R299S	PDK3_ENST00000379162.4_Missense_Mutation_p.R299S	NM_001142386.2	NP_001135858.1	Q15120	PDK3_HUMAN	pyruvate dehydrogenase kinase, isozyme 3	299	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	ATP binding|protein binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity	p.R299C(1)		NS(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						AAAAATAGATCGTCTTTTTAA	0.423000													26	34					3.67414e-24	5.18161e-24	0.163468	1	0
ARHGAP33	115703	broad.mit.edu	37	19	36276318	36276318	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:36276318A>C	ENST00000007510.4	+	19	2019	c.1875A>C	c.(1873-1875)agA>agC	p.R625S	ARHGAP33_ENST00000314737.5_Missense_Mutation_p.R625S|ARHGAP33_ENST00000378944.5_Missense_Mutation_p.R489S			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	625					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CAGGCAGCAGACCCGACACCG	0.662000													44	244					0	0	0.323286	0	0
TMEM2	23670	broad.mit.edu	37	9	74329881	74329881	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:74329881C>G	ENST00000377044.4	-	15	3099	c.2560G>C	c.(2560-2562)Gac>Cac	p.D854H	TMEM2_ENST00000377066.5_Missense_Mutation_p.D791H	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	854						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		GGCTTCTGGTCTATTCCTCCA	0.453000													45	61					0	0	0.323286	0	0
SH3TC2	79628	broad.mit.edu	37	5	148406949	148406949	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:148406949C>A	ENST00000538184.1	-	7	1875	c.987G>T	c.(985-987)caG>caT	p.Q329H	SH3TC2_ENST00000512049.1_Missense_Mutation_p.Q775H|SH3TC2_ENST00000515425.1_Missense_Mutation_p.Q782H|SH3TC2_ENST00000394358.2_Missense_Mutation_p.Q667H			Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	782	SH3.						binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCACCAAGGCCTGGCTCAGGT	0.582000													29	26					3.03874e-20	4.08108e-20	0.183431	1	0
CTSE	1510	broad.mit.edu	37	1	206318450	206318450	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:206318450C>A	ENST00000361052.3	+	2	326	c.208C>A	c.(208-210)Ctc>Atc	p.L70I	CTSE_ENST00000432969.2_Intron|CTSE_ENST00000358184.2_Missense_Mutation_p.L70I|CTSE_ENST00000360218.2_Missense_Mutation_p.L70I			P14091	CATE_HUMAN	cathepsin E	70					antigen processing and presentation of exogenous peptide antigen via MHC class II|digestion|proteolysis	endosome	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|skin(3)	16			BRCA - Breast invasive adenocarcinoma(75;0.0754)			CAAGGAACCCCTCATCAACTA	0.587000													31	88					4.74835e-14	5.83326e-14	0.153744	1	0
MYO16	23026	broad.mit.edu	37	13	109507876	109507876	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:109507876A>T	ENST00000356711.2	+	11	1394	c.1268A>T	c.(1267-1269)aAg>aTg	p.K423M	MYO16_ENST00000251041.5_Missense_Mutation_p.K423M|MYO16_ENST00000357550.2_Missense_Mutation_p.K423M	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	423	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			GAGATTCAGAAGCGCTTTGGG	0.483000													39	166					0	0	0.268233	0	0
ALMS1	7840	broad.mit.edu	37	2	73678173	73678173	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:73678173G>T	ENST00000264448.6	+	8	4627	c.4516G>T	c.(4516-4518)Gga>Tga	p.G1506*	ALMS1_ENST00000377715.1_Nonsense_Mutation_p.G1506*|ALMS1_ENST00000409009.1_Nonsense_Mutation_p.G1464*	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1506	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						AGTTGCTCCTGGACCAGTTGG	0.488000													46	75					1.00776e-21	1.37854e-21	0.323286	1	0
TRAV8-2	28684	broad.mit.edu	37	14	22315123	22315123	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:22315123C>A	ENST00000390434.3	+	0	286																											AACCAGAGCCCAGTCGGTGAC	0.498000											OREG0022570	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	100	336					1.36798e-35	2.14513e-35	0.323286	1	0
DYNC2H1	79659	broad.mit.edu	37	11	103023009	103023009	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:103023009G>C	ENST00000375735.2	+	21	3235	c.3091G>C	c.(3091-3093)Gac>Cac	p.D1031H	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Missense_Mutation_p.D1031H	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1031	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TATGATTAAAGACCAGGTTAG	0.303000													32	79					0	0	0.183431	0	0
PDCD1LG2	80380	broad.mit.edu	37	9	5534897	5534897	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:5534897C>A	ENST00000397747.3	+	3	456	c.208C>A	c.(208-210)Cgt>Agt	p.R70S	PDCD1LG2_ENST00000397745.2_Missense_Mutation_p.R70S	NM_025239.3	NP_079515.2	Q9BQ51	PD1L2_HUMAN	programmed cell death 1 ligand 2	70	Ig-like V-type.				immune response|T cell costimulation	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity			large_intestine(2)|lung(4)|prostate(2)	8	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		ATCCCCACACCGTGAAAGAGC	0.502000													58	126					2.2129e-31	3.35127e-31	0.323286	1	0
CDH23	64072	broad.mit.edu	37	10	73544806	73544806	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:73544806C>T	ENST00000224721.6	+	42	5681	c.5676C>T	c.(5674-5676)acC>acT	p.T1892T		NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	1887	Cadherin 18.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						CACGCCTCACCTTCAACATCA	0.587000													25	39					0	0	0.125774	0	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183048	39183048	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39183048G>T	ENST00000361883.5	-	1	406	c.360C>A	c.(358-360)cgC>cgA	p.R120R		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	120	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament				central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GACTGTCTGGGCGGCACCACC	0.642000													18	30					1.50039e-11	1.76681e-11	0.234183	1	0
REG1A	5967	broad.mit.edu	37	2	79350316	79350316	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:79350316C>A	ENST00000233735.1	+	6	579	c.476C>A	c.(475-477)tCc>tAc	p.S159Y		NM_002909.4	NP_002900.2	P05451	REG1A_HUMAN	regenerating islet-derived 1 alpha	159	C-type lectin.				positive regulation of cell proliferation	extracellular region	growth factor activity|sugar binding			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(26)|prostate(1)|upper_aerodigestive_tract(1)	39						GACAAGTTCTCCTTTGTCTGC	0.423000													31	28					3.86903e-22	5.33261e-22	0.173368	1	0
MEI1	150365	broad.mit.edu	37	22	42125699	42125699	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:42125699G>T	ENST00000401548.3	+	8	935	c.895G>T	c.(895-897)Gtg>Ttg	p.V299L	MEI1_ENST00000540833.1_Missense_Mutation_p.V39L|MEI1_ENST00000300398.4_5'UTR|MEI1_ENST00000400107.1_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	299							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						AACCCTGCAGGTGGCCAGTGC	0.537000													23	2					3.6726e-16	4.65768e-16	0.294199	1	0
RELN	5649	broad.mit.edu	37	7	103141204	103141204	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:103141204G>T	ENST00000424685.2	-	53	8814	c.8655C>A	c.(8653-8655)acC>acA	p.T2885T	CTB-107G13.1_ENST00000422488.1_RNA|RELN_ENST00000428762.1_Silent_p.T2885T|RELN_ENST00000343529.5_Silent_p.T2885T			P78509	RELN_HUMAN	reelin	2885					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TCAGAGTGTGGGTCAAGTAGC	0.493000													48	162					3.76525e-18	4.90163e-18	0.323286	1	0
ST8SIA6	338596	broad.mit.edu	37	10	17373409	17373409	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:17373409C>A	ENST00000377602.4	-	5	594	c.520G>T	c.(520-522)Gtg>Ttg	p.V174L		NM_001004470.1	NP_001004470.1	P61647	SIA8F_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6	174					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			endometrium(3)|kidney(3)|large_intestine(4)|liver(1)|lung(24)|ovary(1)|skin(1)	37						TTACTCACCACTGGAAACATA	0.338000													66	97					1.37693e-34	2.14505e-34	0.323286	1	0
AHRR	57491	broad.mit.edu	37	5	434498	434498	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:434498G>C	ENST00000316418.5	+	12	1753	c.1709G>C	c.(1708-1710)tGt>tCt	p.C570S	AHRR_ENST00000506456.1_Missense_Mutation_p.C408S|AHRR_ENST00000505113.1_Missense_Mutation_p.C552S|AHRR_ENST00000512529.1_Missense_Mutation_p.C398S	NM_020731.4	NP_065782.2	A9YTQ3	AHRR_HUMAN	aryl-hydrocarbon receptor repressor	552	Needed for transcriptional repression (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(2)|endometrium(4)|large_intestine(1)|lung(12)|prostate(1)	20			Epithelial(17;0.0011)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00354)|Lung(60;0.0863)			GCAGACGGCTGTGTGCCCAGC	0.622000													8	20					0	0	0.105934	0	0
PCDHA1	56147	broad.mit.edu	37	5	140166187	140166187	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140166187C>G	ENST00000504120.2	+	1	312	c.312C>G	c.(310-312)atC>atG	p.I104M	PCDHA1_ENST00000378133.3_Missense_Mutation_p.I104M|PCDHA1_ENST00000394633.3_Missense_Mutation_p.I104M	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTGCAGCATCCACCTGGAGT	0.537000													38	34					0	0	0.268233	0	0
PTPRH	5794	broad.mit.edu	37	19	55698887	55698887	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:55698887G>T	ENST00000376350.3	-	14	2582	c.2560C>A	c.(2560-2562)Ctg>Atg	p.L854M	PTPRH_ENST00000263434.5_Missense_Mutation_p.L676M	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	854	Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		TCACAGGGCAGCACATTTCTG	0.587000													86	49					2.10502e-31	3.19258e-31	0.323286	1	0
PKNOX2	63876	broad.mit.edu	37	11	125280125	125280125	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:125280125G>A	ENST00000298282.9	+	8	893	c.622G>A	c.(622-624)Gga>Aga	p.G208R	PKNOX2_ENST00000530517.1_3'UTR|PKNOX2_ENST00000542175.1_Missense_Mutation_p.G144R	NM_022062.2	NP_071345.2	Q96KN3	PKNX2_HUMAN	PBX/knotted 1 homeobox 2	208						nucleus	sequence-specific DNA binding transcription factor activity	p.G208R(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(14)|ovary(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	29		Breast(109;0.00234)|all_lung(97;0.0191)|Lung NSC(97;0.0196)|Medulloblastoma(222;0.0447)|all_neural(223;0.116)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.117)		TTCCATGTCCGGAGTCTCCAA	0.572000													6	506					0	0	0.248553	0	0
ASAP2	8853	broad.mit.edu	37	2	9437490	9437490	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:9437490A>G	ENST00000281419.3	+	3	601	c.261A>G	c.(259-261)gtA>gtG	p.V87V	ASAP2_ENST00000315273.4_Silent_p.V87V	NM_003887.2	NP_003878.1	O43150	ASAP2_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	87					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						GCAACTGTGTATGCAGAGATG	0.483000													22	32					0	0	0.309145	0	0
HSH2D	84941	broad.mit.edu	37	19	16263858	16263858	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:16263858A>G	ENST00000593154.2	+	6	752	c.221A>G	c.(220-222)cAa>cGa	p.Q74R	HSH2D_ENST00000397372.4_Intron|HSH2D_ENST00000253680.6_Missense_Mutation_p.Q74R|HSH2D_ENST00000588246.1_Missense_Mutation_p.Q74R	NM_032855.2	NP_116244.1	Q96JZ2	HSH2D_HUMAN	hematopoietic SH2 domain containing	74	SH2.					cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|large_intestine(2)	4						CGCAGAGCCCAAAGCAGCTGC	0.637000													5	8					0	0	0.307466	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123477487	123477487	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:123477487T>G	ENST00000529750.1	+	10	1392	c.1065T>G	c.(1063-1065)tcT>tcG	p.S355S	GRAMD1B_ENST00000322282.7_Silent_p.S355S|GRAMD1B_ENST00000456860.2_Silent_p.S362S	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	355						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TCAGTGACTCTTCCGACACAC	0.493000													62	183					0	0	0.323286	0	0
CDH10	1008	broad.mit.edu	37	5	24488111	24488111	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:24488111C>A	ENST00000264463.4	-	12	2535	c.2028G>T	c.(2026-2028)agG>agT	p.R676S	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	676					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CTGCAGGATTCCTCAGGGTGC	0.473000										HNSCC(23;0.051)			71	77					1.69816e-31	2.57677e-31	0.323286	1	0
AGMO	392636	broad.mit.edu	37	7	15433805	15433805	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:15433805C>A	ENST00000342526.3	-	6	779		c.e6-1		AGMO_ENST00000498264.1_Splice_Site	NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase						ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						TATTGATGACCTGTTTAAAAC	0.313000													24	127					1.75199e-13	2.13031e-13	0.125774	1	0
OR8H2	390151	broad.mit.edu	37	11	55873016	55873016	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55873016G>T	ENST00000313503.1	+	1	498	c.498G>T	c.(496-498)ttG>ttT	p.L166F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	166					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L166F(2)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TGAGCAGATTGCATTTCTACG	0.423000										HNSCC(53;0.14)			5	439					0.0215528	0.0219352	0.217242	1	0
DHX37	57647	broad.mit.edu	37	12	125432557	125432557	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:125432557C>T	ENST00000544745.1	-	23	2931	c.2822G>A	c.(2821-2823)tGc>tAc	p.C941Y	DHX37_ENST00000308736.2_Intron			Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	0							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GCTGACCGTGCACAAAGCACA	0.612000													5	9					0	0	0.278610	0	0
SERPIND1	3053	broad.mit.edu	37	22	21134267	21134267	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:21134267G>T	ENST00000215727.5	+	2	950	c.667G>T	c.(667-669)Gac>Tac	p.D223Y	PI4KA_ENST00000255882.6_Intron|PI4KA_ENST00000572273.1_Intron|PI4KA_ENST00000466162.1_Intron|SERPIND1_ENST00000406799.1_Missense_Mutation_p.D223Y	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	223					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	GTCAGTCAATGACCTTTATAT	0.443000													17	103					2.23348e-06	2.40595e-06	0.146539	1	0
TFDP2	7029	broad.mit.edu	37	3	141682713	141682713	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:141682713T>A	ENST00000499676.2	-	10	1316	c.645A>T	c.(643-645)ccA>ccT	p.P215P	TFDP2_ENST00000495310.1_Silent_p.P178P|TFDP2_ENST00000397991.4_Silent_p.P247P|TFDP2_ENST00000477292.1_Silent_p.P139P|TFDP2_ENST00000467072.1_Silent_p.P215P|TFDP2_ENST00000310282.6_Silent_p.P215P|TFDP2_ENST00000479040.1_Silent_p.P214P|TFDP2_ENST00000317104.7_Silent_p.P199P|TFDP2_ENST00000486111.1_Silent_p.P215P|TFDP2_ENST00000489671.1_Silent_p.P275P	NM_001178139.1	NP_001171610.1	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization partner 2)	275					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)|upper_aerodigestive_tract(2)	3						TGATTATGAATGGCAGCTGAA	0.473000													31	74					0	0	0.257332	0	0
MITF	4286	broad.mit.edu	37	3	70014048	70014048	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:70014048G>T	ENST00000352241.4	+	10	1375	c.1212G>T	c.(1210-1212)acG>acT	p.T404T	MITF_ENST00000314557.6_Silent_p.T297T|MITF_ENST00000472437.1_Silent_p.T352T|MITF_ENST00000394351.3_Silent_p.T303T|MITF_ENST00000314589.5_Silent_p.T388T|MITF_ENST00000394355.2_Silent_p.T379T|MITF_ENST00000531774.1_Silent_p.T241T|MITF_ENST00000328528.6_Silent_p.T403T|MITF_ENST00000448226.2_Silent_p.T410T	NM_198159.2	NP_937802.1	O75030	MITF_HUMAN	microphthalmia-associated transcription factor	410	DNA binding regulation.				melanocyte differentiation|multicellular organismal development|protein complex assembly	nucleus|protein complex	DNA binding|protein binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(6)|stomach(1)|urinary_tract(2)	30		Lung NSC(201;0.0384)|Prostate(884;0.0526)		BRCA - Breast invasive adenocarcinoma(55;3.07e-05)|Epithelial(33;0.000138)|LUSC - Lung squamous cell carcinoma(21;0.008)|Lung(16;0.0107)|KIRC - Kidney renal clear cell carcinoma(39;0.204)|Kidney(39;0.239)		TTCCATCCACGGGTCTCTGCT	0.463000			A		melanoma		"""Waardenburg syndrome type 2, Tietz syndrome"""						98	58					3.33393e-45	5.51264e-45	0.323286	1	0
RYR2	6262	broad.mit.edu	37	1	237756932	237756932	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:237756932G>T	ENST00000366574.2	+	33	4749	c.4432G>T	c.(4432-4434)Gaa>Taa	p.E1478*	RYR2_ENST00000360064.6_Nonsense_Mutation_p.E1476*|RYR2_ENST00000542537.1_Nonsense_Mutation_p.E1462*	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1478	4 X approximate repeats.|B30.2/SPRY 3.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAAGTGCATGAAAGGTTAGT	0.363000													41	132					1.68508e-10	1.94148e-10	0.279185	1	0
OR1I1	126370	broad.mit.edu	37	19	15198808	15198808	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:15198808C>T	ENST00000209540.2	+	1	1018	c.932C>T	c.(931-933)cCc>cTc	p.P311L		NM_001004713.1	NP_001004713.1	O60431	OR1I1_HUMAN	olfactory receptor, family 1, subfamily I, member 1	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(3)|ovary(2)|stomach(2)	20						GTGGCCGTCCCCTGTCCTAGG	0.532000													23	10					0	0	0.324025	0	0
SHBG	6462	broad.mit.edu	37	17	7536237	7536237	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:7536237G>T	ENST00000380450.4	+	7	1051	c.1020G>T	c.(1018-1020)tgG>tgT	p.W340C	SHBG_ENST00000570547.1_Intron|SHBG_ENST00000574539.1_Intron|SHBG_ENST00000575903.1_Missense_Mutation_p.W322C|SHBG_ENST00000572262.1_Missense_Mutation_p.W228C|SHBG_ENST00000576478.1_Intron|SHBG_ENST00000575314.1_Missense_Mutation_p.W282C|SHBG_ENST00000572182.1_Intron|SHBG_ENST00000441599.2_Intron|SHBG_ENST00000340624.5_Intron|SHBG_ENST00000416273.3_Intron|SHBG_ENST00000576728.1_Intron	NM_001040.3	NP_001031.2	P04278	SHBG_HUMAN	sex hormone-binding globulin	340	Laminin G-like 2.				hormone transport	extracellular region	androgen binding|protein homodimerization activity	p.0?(1)|p.?(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_cancers(10;0.0867)		READ - Rectum adenocarcinoma(115;0.168)	Danazol(DB01406)|Dromostanolone(DB00858)|Estradiol(DB00783)|Estrone(DB00655)|Fluoxymesterone(DB01185)|Hydrocortisone(DB00741)|Mitotane(DB00648)|Norethindrone(DB00717)|Testosterone(DB00624)	TTAACCTCTGGGCCAAGCCTC	0.557000											OREG0024140	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	14					1.5739e-10	1.81947e-10	0.146539	1	0
PCDHB8	56128	broad.mit.edu	37	5	140559229	140559229	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140559229C>A	ENST00000239444.2	+	1	1859	c.1614C>A	c.(1612-1614)ggC>ggA	p.G538G		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		538	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CAGACCGCGGCTCCCCGGCTT	0.667000													38	46					4.44401e-20	5.95033e-20	0.290176	1	0
ELAVL2	1993	broad.mit.edu	37	9	23762137	23762137	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:23762137C>A	ENST00000397312.2	-	2	370	c.96G>T	c.(94-96)ggG>ggT	p.G32G	ELAVL2_ENST00000544538.1_Silent_p.G32G|ELAVL2_ENST00000380110.4_Silent_p.G61G|ELAVL2_ENST00000380117.1_Silent_p.G32G|ELAVL2_ENST00000223951.6_Silent_p.G32G	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	32					regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CTTCTGTGTTCCCAGAGTCAA	0.448000													184	374					5.08084e-95	9.22894e-95	0.323286	1	0
E2F7	144455	broad.mit.edu	37	12	77421834	77421834	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:77421834C>A	ENST00000322886.7	-	11	2204	c.1969G>T	c.(1969-1971)Ggc>Tgc	p.G657C	E2F7_ENST00000416496.2_Missense_Mutation_p.G657C	NM_203394.2	NP_976328.2	Q96AV8	E2F7_HUMAN	E2F transcription factor 7	657					cell cycle	transcription factor complex	DNA binding|identical protein binding			central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(15)|lung(14)|ovary(3)|upper_aerodigestive_tract(2)	42						GGGAGTTGGCCATTCACATGA	0.443000													52	73					2.64514e-33	4.08986e-33	0.323286	1	0
DNM1	1759	broad.mit.edu	37	9	130982360	130982360	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:130982360G>T	ENST00000341179.7	+	5	775	c.683G>T	c.(682-684)cGc>cTc	p.R228L	DNM1_ENST00000393594.3_Missense_Mutation_p.R228L|DNM1_ENST00000372923.3_Missense_Mutation_p.R228L|DNM1_ENST00000486160.1_Missense_Mutation_p.R228L|DNM1_ENST00000475805.1_Missense_Mutation_p.R228L	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	228					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						CTCCCCCTGCGCAGAGGTAAG	0.627000													19	12					1.10513e-12	1.32402e-12	0.249174	1	0
MLLT10	8028	broad.mit.edu	37	10	21962540	21962540	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:21962540G>T	ENST00000377072.3	+	11	1661	c.1313G>T	c.(1312-1314)gGa>gTa	p.G438V	MLLT10_ENST00000377059.3_Missense_Mutation_p.G438V|MLLT10_ENST00000446906.2_Missense_Mutation_p.G438V|MLLT10_ENST00000307729.7_Missense_Mutation_p.G438V	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	438	DNA-binding.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						AATTCACCTGGAGATTTGGGT	0.428000			T	"""MLL, PICALM, CDK6"""	AL								178	674					1.80353e-92	3.27406e-92	0.323286	1	0
HDAC9	9734	broad.mit.edu	37	7	18669096	18669096	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:18669096A>G	ENST00000406451.3	+	7	929	c.779A>G	c.(778-780)gAg>gGg	p.E260G	HDAC9_ENST00000405010.3_Missense_Mutation_p.E260G|HDAC9_ENST00000417496.2_Intron|HDAC9_ENST00000456174.2_Missense_Mutation_p.E232G|HDAC9_ENST00000441542.2_Missense_Mutation_p.E263G|HDAC9_ENST00000406072.1_Intron|HDAC9_ENST00000524023.1_Intron|HDAC9_ENST00000432645.2_Missense_Mutation_p.E260G|HDAC9_ENST00000401921.1_Intron|HDAC9_ENST00000428307.2_Intron	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	260	Interaction with ETV6.|Interaction with MAPK10 (By similarity).				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CGAATGTTTGAGGTGACAGGT	0.418000													13	161					0	0	0.160694	0	0
NEIL3	55247	broad.mit.edu	37	4	178243682	178243682	+	Missense_Mutation	SNP	G	G	T	rs34112288	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:178243682G>T	ENST00000264596.3	+	2	344	c.226G>T	c.(226-228)Gtg>Ttg	p.V76L		NM_018248.2	NP_060718.2	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3 (E. coli)	76			V -> M (in dbSNP:rs34112288).		base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding	p.V76L(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		TTACAGTGGCGTGGAAACTTT	0.393000								Base excision repair (BER), DNA glycosylases					26	101					4.22769e-11	4.94642e-11	0.116897	1	0
PTPRD	5789	broad.mit.edu	37	9	8500792	8500792	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:8500792G>T	ENST00000381196.4	-	21	2633	c.2090C>A	c.(2089-2091)cCt>cAt	p.P697H	PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.P697H|PTPRD_ENST00000360074.4_Missense_Mutation_p.P684H|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.P697H|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.P684H	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	697	Fibronectin type-III 4.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CAAGCTCTCAGGGCCAGGGCC	0.493000										TSP Lung(15;0.13)			81	255					9.47799e-51	1.60138e-50	0.323286	1	0
NYAP2	57624	broad.mit.edu	37	2	226447029	226447029	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:226447029C>A	ENST00000272907.6	+	4	1309	c.896C>A	c.(895-897)cCc>cAc	p.P299H	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	299																	TGTGCTACTCCCACGGTGCCT	0.577000													63	123					4.83814e-26	6.94333e-26	0.323286	1	0
CPXM1	56265	broad.mit.edu	37	20	2778897	2778897	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:2778897C>A	ENST00000380605.2	-	4	555	c.491G>T	c.(490-492)tGt>tTt	p.C164F		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	164	F5/8 type C.				cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CTCCTCAGCACACCAGGCTCC	0.617000													98	11					1.1777e-47	1.96198e-47	0.323286	1	0
TBC1D3	729873	broad.mit.edu	37	17	36351998	36351998	+	Splice_Site	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:36351998T>C	ENST00000537432.1	-	5	427		c.e5-2		RP11-1407O15.2_ENST00000544906.1_Splice_Site|RP11-1407O15.2_ENST00000312412.4_Splice_Site			Q8IZP1	TBC3A_HUMAN	TBC1 domain family, member 3							intracellular	Rab GTPase activator activity			breast(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5	Breast(7;2.97e-12)	Breast(25;0.102)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CTTAAAGTCCTGAGAAAACAC	0.303000													3	33					0	0	0.150653	0	0
THSD7B	80731	broad.mit.edu	37	2	137990656	137990656	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:137990656G>T	ENST00000409968.1	+	9	2281	c.2103G>T	c.(2101-2103)cgG>cgT	p.R701R	THSD7B_ENST00000413152.2_Silent_p.R670R|THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000272643.3_Silent_p.R701R					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTCAGACTCGGAGAGTCTTCT	0.453000													39	121					1.61572e-30	2.42908e-30	0.290176	1	0
EIF4G1	1981	broad.mit.edu	37	3	184039242	184039242	+	Missense_Mutation	SNP	G	G	C	rs144947145	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:184039242G>C	ENST00000342981.4	+	9	1284	c.870G>C	c.(868-870)atG>atC	p.M290I	EIF4G1_ENST00000350481.5_Missense_Mutation_p.M126I|EIF4G1_ENST00000352767.3_Missense_Mutation_p.M297I|EIF4G1_ENST00000424196.1_Missense_Mutation_p.M297I|EIF4G1_ENST00000435046.2_Missense_Mutation_p.M94I|EIF4G1_ENST00000427845.1_Missense_Mutation_p.M203I|EIF4G1_ENST00000414031.1_Missense_Mutation_p.M250I|EIF4G1_ENST00000382330.3_Missense_Mutation_p.M297I|EIF4G1_ENST00000411531.1_Missense_Mutation_p.M250I|EIF4G1_ENST00000392537.2_Missense_Mutation_p.M203I|EIF4G1_ENST00000346169.2_Missense_Mutation_p.M290I|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000441154.1_Missense_Mutation_p.M126I|EIF4G1_ENST00000319274.6_Missense_Mutation_p.M290I|EIF4G1_ENST00000434061.2_Missense_Mutation_p.M94I	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	290					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGGACACTATGACAACTATAC	0.557000													19	46					0	0	0.189662	0	0
MKL2	57496	broad.mit.edu	37	16	14334351	14334351	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:14334351G>T	ENST00000572567.1	+	8	1254	c.1056G>T	c.(1054-1056)ggG>ggT	p.G352G	MKL2_ENST00000573051.1_Intron|MKL2_ENST00000574045.1_Intron|MKL2_ENST00000571589.1_Intron|MKL2_ENST00000341243.5_Intron|MKL2_ENST00000318282.5_Intron			Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	0					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGTACGGCGGGGCCCATGCTA	0.473000													164	21					1.17582e-108	2.15985e-108	0.323286	1	0
GSG2	83903	broad.mit.edu	37	17	3627904	3627904	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:3627904A>T	ENST00000325418.4	+	1	694	c.675A>T	c.(673-675)acA>acT	p.T225T	ITGAE_ENST00000263087.4_Intron|ITGAE_ENST00000571185.1_5'UTR	NM_031965.2	NP_114171.2	Q8TF76	HASP_HUMAN	germ cell associated 2 (haspin)	225					cell cycle|chromatin modification|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity										AGGAAGCGACAGGAGGAGCCA	0.622000													31	1					0	0	0.225048	0	0
HS3ST3A1	9955	broad.mit.edu	37	17	13399540	13399540	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:13399540C>A	ENST00000284110.1	-	2	1992	c.1195G>T	c.(1195-1197)Ggg>Tgg	p.G399W	HS3ST3A1_ENST00000578576.1_Missense_Mutation_p.G197W	NM_006042.1	NP_006033.1	Q9Y663	HS3SA_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	399						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AAGTCGTGCCCGGTCATCTGG	0.448000													139	13					3.42239e-116	6.30151e-116	0.323286	1	0
ALK	238	broad.mit.edu	37	2	29455249	29455249	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:29455249G>T	ENST00000389048.3	-	15	3459	c.2553C>A	c.(2551-2553)gcC>gcA	p.A851A	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	851	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TGTCTGTCTTGGCCCCGTAGG	0.587000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				18	104					4.35082e-09	4.87499e-09	0.219247	1	0
LRBA	987	broad.mit.edu	37	4	151753066	151753066	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:151753066C>G	ENST00000535741.1	-	29	5105	c.4632G>C	c.(4630-4632)atG>atC	p.M1544I	LRBA_ENST00000510413.1_Missense_Mutation_p.M1544I|LRBA_ENST00000507224.1_Missense_Mutation_p.M1544I|LRBA_ENST00000357115.3_Missense_Mutation_p.M1544I			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1544						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ACTTGGAGACCATAAGAACAG	0.378000													41	8					0	0	0.323286	0	0
PCDH15	65217	broad.mit.edu	37	10	55581965	55581965	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:55581965C>A	ENST00000361849.3	-	34	5921	c.5527G>T	c.(5527-5529)Gtc>Ttc	p.V1843F	PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.V1838F|PCDH15_ENST00000437009.1_Missense_Mutation_p.V1772F|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000395433.1_Missense_Mutation_p.V1818F|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000320301.6_Missense_Mutation_p.V1841F|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000395432.2_Missense_Mutation_p.V1801F|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000373957.3_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1841					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GTTATACAGACACACTCTGTG	0.463000										HNSCC(58;0.16)			34	38					4.3181e-19	5.70527e-19	0.173368	1	0
MAF	4094	broad.mit.edu	37	16	79628399	79628399	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:79628399C>A	ENST00000326043.4	-	2	1981	c.1170G>T	c.(1168-1170)tgG>tgT	p.W390C	MAF_ENST00000393350.1_3'UTR|MAF_ENST00000569649.1_Intron	NM_005360.4	NP_005351.2	O75444	MAF_HUMAN	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog	0					transcription from RNA polymerase II promoter	chromatin|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)	10		all_epithelial(2;0.139)|Lung NSC(2;0.186)|Melanoma(2;0.211)		UCEC - Uterine corpus endometrioid carcinoma (2;0.0178)		GCTGGGGCTTCCAAAATGTGG	0.368000			T	IGH@	MM								4	8					0.00198382	0.00204251	0.248553	1	0
KIRREL	55243	broad.mit.edu	37	1	158061169	158061169	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158061169T>G	ENST00000368172.1	+	7	748	c.736T>G	c.(736-738)Ttc>Gtc	p.F246V	KIRREL_ENST00000392272.2_Missense_Mutation_p.F329V|KIRREL_ENST00000368173.3_Missense_Mutation_p.F448V|KIRREL_ENST00000359209.6_Missense_Mutation_p.F432V|KIRREL_ENST00000416935.2_Missense_Mutation_p.F332V|KIRREL_ENST00000360089.4_Missense_Mutation_p.F268V			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	432	Ig-like C2-type 3.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					GAAGGAGAACTTCTTGGAGGT	0.592000													5	144					0	0	0.184627	0	0
RASA3	22821	broad.mit.edu	37	13	114786936	114786936	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:114786936C>A	ENST00000334062.7	-	9	850	c.729G>T	c.(727-729)ctG>ctT	p.L243L	RASA3_ENST00000389544.4_Silent_p.L211L|RASA3_ENST00000542651.1_3'UTR	NM_007368.2	NP_031394.2	Q14644	RASA3_HUMAN	RAS p21 protein activator 3	243	C2 2.				intracellular signal transduction|negative regulation of Ras protein signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	calcium-release channel activity|metal ion binding|Ras GTPase activator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	47	Lung NSC(43;0.00814)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.016)|all_epithelial(44;0.00577)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.188)	BRCA - Breast invasive adenocarcinoma(86;0.128)			TTAGTTCTCCCAGGAATTCAT	0.542000													9	31					0.00829132	0.00848867	0.069234	1	0
VAMP4	8674	broad.mit.edu	37	1	171675514	171675514	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:171675514C>A	ENST00000236192.7	-	7	776	c.390G>T	c.(388-390)gtG>gtT	p.V130V	VAMP4_ENST00000367740.2_Silent_p.V129V|VAMP4_ENST00000415773.1_Silent_p.V129V|VAMP4_ENST00000482519.1_5'UTR	NM_001185127.1|NM_003762.4	NP_001172056.1|NP_003753.2	O75379	VAMP4_HUMAN	vesicle-associated membrane protein 4	130					vesicle-mediated transport	endosome|Golgi membrane|integral to membrane|lysosome				large_intestine(4)	4	all_cancers(6;1.42e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TACTGATAATCACTAGCAAAA	0.308000													112	70					2.27795e-59	3.98126e-59	0.323286	1	0
OGFRL1	79627	broad.mit.edu	37	6	72011638	72011638	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:72011638C>A	ENST00000370435.4	+	7	1376	c.1242C>A	c.(1240-1242)ccC>ccA	p.P414P	RP11-154D6.1_ENST00000591156.1_RNA|RP11-154D6.1_ENST00000423255.1_RNA|RP11-154D6.1_ENST00000586232.1_RNA|RP11-154D6.1_ENST00000587253.1_RNA|RP11-154D6.1_ENST00000586030.1_RNA|RP11-154D6.1_ENST00000432050.1_RNA|RP11-154D6.1_ENST00000588612.1_RNA|RP3-331H24.5_ENST00000602823.1_lincRNA|RP11-154D6.1_ENST00000412751.1_RNA	NM_024576.3	NP_078852.3	Q5TC84	OGRL1_HUMAN	opioid growth factor receptor-like 1	414						membrane	receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|upper_aerodigestive_tract(1)	13						TTACTACTCCCACAGAAAAAA	0.413000													70	187					2.48295e-43	4.07725e-43	0.323286	1	0
RAB11FIP2	22841	broad.mit.edu	37	10	119805345	119805345	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:119805345C>A	ENST00000355624.3	-	1	769	c.330G>T	c.(328-330)gaG>gaT	p.E110D	RAB11FIP2_ENST00000369199.3_Missense_Mutation_p.E110D	NM_014904.2	NP_055719.1	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2 (class I)	110					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(8)	19		Colorectal(252;0.235)		all cancers(201;0.0238)		TTTGTTTGTCCTCAAAGATGT	0.348000													3	24					0.004672	0.00479271	0.115264	1	0
TRBV6-1	28606	broad.mit.edu	37	7	142028382	142028382	+	RNA	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142028382C>T	ENST00000390353.2	+	0	173																											CAGAGCATGACACTGCAGTGT	0.507000													169	274					0	0	0.323286	0	0
SMARCA2	6595	broad.mit.edu	37	9	2086930	2086930	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:2086930G>C	ENST00000382203.1	+	18	2837	c.2628G>C	c.(2626-2628)agG>agC	p.R876S	SMARCA2_ENST00000382194.1_Missense_Mutation_p.R876S|SMARCA2_ENST00000357248.2_Missense_Mutation_p.R876S|SMARCA2_ENST00000349721.2_Missense_Mutation_p.R876S			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	876	Helicase ATP-binding.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CCCCCAGAAGGATCCTCTTGA	0.512000													67	343					0	0	0.323286	0	0
ASIC2	40	broad.mit.edu	37	17	31618817	31618817	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:31618817T>G	ENST00000225823.2	-	1	1189	c.317A>C	c.(316-318)aAc>aCc	p.N106T	ASIC2_ENST00000359872.6_Intron	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	62					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	GAGCAAGCGGTTCGAGGACCA	0.667000													10	24					0	0	0.119110	0	0
RIOK2	55781	broad.mit.edu	37	5	96503604	96503604	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:96503604C>A	ENST00000283109.3	-	8	1032	c.964G>T	c.(964-966)Gat>Tat	p.D322Y	RIOK2_ENST00000508447.1_Missense_Mutation_p.D322Y|CTD-2215E18.1_ENST00000509481.1_Intron	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2	322	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		TTTTTATCATCTGGACCTAAT	0.403000													75	92					9.07738e-34	1.40634e-33	0.323286	1	0
HTT	3064	broad.mit.edu	37	4	3174833	3174833	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:3174833G>A	ENST00000355072.5	+	31	4286	c.4141G>A	c.(4141-4143)Gcg>Acg	p.A1381T		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1381					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CATGGTGCAGGCGGAGCAGGA	0.552000													8	45					0	0	0.058154	0	0
TCF21	6943	broad.mit.edu	37	6	134210962	134210962	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:134210962G>T	ENST00000367882.4	+	1	687	c.427G>T	c.(427-429)Ggg>Tgg	p.G143W	RP3-323P13.2_ENST00000607573.1_RNA|TCF21_ENST00000237316.3_Missense_Mutation_p.G143W	NM_003206.3	NP_003197.2	O43680	TCF21_HUMAN	transcription factor 21	143					branching involved in ureteric bud morphogenesis|mesoderm development|negative regulation of androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	androgen receptor binding|E-box binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	13	Colorectal(23;0.221)|Breast(56;0.247)			GBM - Glioblastoma multiforme(68;0.00518)|OV - Ovarian serous cystadenocarcinoma(155;0.00783)		ATACGAGAACGGGTACATTCA	0.672000													105	101					4.43683e-73	7.91069e-73	0.323286	1	0
MED12L	116931	broad.mit.edu	37	3	151107867	151107867	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:151107867T>G	ENST00000474524.1	+	36	5485	c.5447T>G	c.(5446-5448)cTc>cGc	p.L1816R	MED12L_ENST00000273432.4_Missense_Mutation_p.L1676R	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1816					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex		p.L1816H(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GGTTACAACCTCGTGGGCCAG	0.502000													87	213					0	0	0.323286	0	0
APP	351	broad.mit.edu	37	21	27254076	27254076	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:27254076C>A	ENST00000358918.3	-	17	2363	c.2164G>T	c.(2164-2166)Gcc>Tcc	p.A722S	APP_ENST00000357903.3_Missense_Mutation_p.A721S|APP_ENST00000354192.3_Missense_Mutation_p.A609S|APP_ENST00000348990.5_Missense_Mutation_p.A665S|APP_ENST00000448388.2_Missense_Mutation_p.A630S|APP_ENST00000346798.3_Missense_Mutation_p.A740S|APP_ENST00000440126.3_Missense_Mutation_p.A716S|APP_ENST00000439274.2_Missense_Mutation_p.A684S|APP_ENST00000359726.3_Missense_Mutation_p.A684S	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	740					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				GTGACAGCGGCGTCAACCTGA	0.453000											OREG0026148	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	74	7					5.71386e-39	9.15933e-39	0.323286	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32890962	32890962	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:32890962C>A	ENST00000330048.5	-	0	3004					NR_003083.2																						CACCACCACGCACTCCCAAAA	0.637000													25	2					2.81731e-10	3.22678e-10	0.153744	1	0
SLC38A6	145389	broad.mit.edu	37	14	61518588	61518588	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:61518588T>A	ENST00000354886.2	+	14	1298	c.1134T>A	c.(1132-1134)aaT>aaA	p.N378K	SLC38A6_ENST00000456840.2_Missense_Mutation_p.N355K|SLC38A6_ENST00000267488.4_Missense_Mutation_p.N378K	NM_001172702.1	NP_001166173.1	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	378					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TAGCACTCAATATTATCATCG	0.308000													34	94					0	0	0.183431	0	0
GBA3	57733	broad.mit.edu	37	4	22729009	22729009	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:22729009C>A	ENST00000511446.1	+	0	61				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000508166.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CATAGCAGCACACACCTGCGG	0.423000													32	70					8.20599e-20	1.09307e-19	0.301197	1	0
KAT6B	23522	broad.mit.edu	37	10	76788500	76788500	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:76788500G>A	ENST00000287239.4	+	18	4407	c.3918G>A	c.(3916-3918)agG>agA	p.R1306R	KAT6B_ENST00000372711.1_Silent_p.R1123R|KAT6B_ENST00000372724.1_Silent_p.R1014R|KAT6B_ENST00000372725.1_Silent_p.R1014R|KAT6B_ENST00000372714.1_Silent_p.R1014R	NM_001256468.1|NM_012330.3	NP_001243397.1|NP_036462.2	Q8WYB5	MYST4_HUMAN	K(lysine) acetyltransferase 6B	1306					histone H3 acetylation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription factor binding|zinc ion binding										GTCCCATCAGGATTGAGGAGG	0.522000													65	91					0	0	0.323286	0	0
OR1N2	138882	broad.mit.edu	37	9	125316168	125316168	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:125316168G>T	ENST00000373688.2	+	1	778	c.720G>T	c.(718-720)tgG>tgT	p.W240C		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						GCATTTTCTGGGCTGTGTTTG	0.507000													112	150					1.99536e-56	3.45038e-56	0.323286	1	0
SLIT2	9353	broad.mit.edu	37	4	20611668	20611668	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:20611668T>A	ENST00000504154.1	+	34	3977	c.3725T>A	c.(3724-3726)aTt>aAt	p.I1242N	SLIT2_ENST00000273739.5_Missense_Mutation_p.I1255N|SLIT2_ENST00000503823.1_Missense_Mutation_p.I1234N|SLIT2_ENST00000503837.1_Missense_Mutation_p.I1238N	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1242	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AACTTCCACATTGTGGAACTA	0.388000													12	43					0	0	0.203993	0	0
SEMA5A	9037	broad.mit.edu	37	5	9052122	9052122	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:9052122G>T	ENST00000382496.5	-	20	3373	c.2708C>A	c.(2707-2709)tCg>tAg	p.S903*		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	903	TSP type-1 7.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						AGACCAGTCCGACCACTCCGA	0.592000													15	17					1.2644e-06	1.37014e-06	0.219247	1	0
AP3D1	8943	broad.mit.edu	37	19	2115419	2115419	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:2115419T>A	ENST00000355272.6	-	20	2356		c.e20-2		AP3D1_ENST00000356926.4_Splice_Site|AP3D1_ENST00000345016.5_Splice_Site|AP3D1_ENST00000350812.6_Splice_Site	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit						eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGGCAGCCCTGCGGGCCGGC	0.657000													7	3					0	0	0.105934	0	0
TTN	7273	broad.mit.edu	37	2	179454551	179454551	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179454551G>T	ENST00000589042.1	-	304	62125	c.61901C>A	c.(61900-61902)gCc>gAc	p.A20634D	TTN_ENST00000342175.6_Missense_Mutation_p.A11761D|TTN_ENST00000359218.5_Missense_Mutation_p.A11694D|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.A18993D|TTN_ENST00000460472.2_Missense_Mutation_p.A11569D|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.A18066D|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000586452.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	18993							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCATTGTTGGCTAAAAGGTT	0.388000													67	140					1.1794e-34	1.83918e-34	0.323286	1	0
RBM6	10180	broad.mit.edu	37	3	50085713	50085713	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:50085713G>T	ENST00000443081.1	+	7	2116	c.1197G>T	c.(1195-1197)ctG>ctT	p.L399L	RBM6_ENST00000539992.1_Intron|RBM6_ENST00000266022.4_Silent_p.L531L|RBM6_ENST00000422955.1_Silent_p.L9L|RBM6_ENST00000441115.1_3'UTR|RBM6_ENST00000442092.1_Silent_p.L9L			P78332	RBM6_HUMAN	RNA binding motif protein 6	531					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		AAGTTACCCTGGAGTATGTAT	0.418000													16	41					1.33834e-09	1.51548e-09	0.189662	1	0
CERS4	79603	broad.mit.edu	37	19	8321918	8321918	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:8321918C>G	ENST00000558331.1	+	9	1004	c.545C>G	c.(544-546)tCt>tGt	p.S182C	CERS4_ENST00000251363.5_Missense_Mutation_p.S233C|CERS4_ENST00000559450.1_Missense_Mutation_p.S233C|CERS4_ENST00000559336.1_Missense_Mutation_p.S233C|CERS4_ENST00000595722.1_3'UTR			Q9HA82	CERS4_HUMAN	ceramide synthase 4	233	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										CGCATTGGCTCTCTGGTGCTG	0.597000													157	18					0	0	0.323286	0	0
NPHS1	4868	broad.mit.edu	37	19	36333144	36333144	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:36333144C>G	ENST00000378910.5	-	19	2544	c.2545G>C	c.(2545-2547)Gtg>Ctg	p.V849L	NPHS1_ENST00000353632.6_Missense_Mutation_p.V849L	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	849	Ig-like C2-type 8.				cell adhesion|excretion|muscle organ development	integral to plasma membrane				NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCTGCAGCCACCTTAGTTAGG	0.597000													9	45					0	0	0.093190	0	0
AGBL2	79841	broad.mit.edu	37	11	47698822	47698822	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:47698822C>A	ENST00000525123.1	-	14	2433		c.e14+1		AGBL2_ENST00000529712.1_Intron|AGBL2_ENST00000357610.3_Splice_Site|AGBL2_ENST00000528244.1_Splice_Site|AGBL2_ENST00000298861.4_Splice_Site	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2						proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						TTCTTTGTTACCTGGATTCAA	0.323000													16	26					0.000132079	0.000138755	0.204396	1	0
UBFD1	56061	broad.mit.edu	37	16	23570949	23570949	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:23570949G>T	ENST00000395878.3	+	3	897	c.516G>T	c.(514-516)caG>caT	p.Q172H	UBFD1_ENST00000571064.1_3'UTR|UBFD1_ENST00000567264.1_Missense_Mutation_p.Q172H|UBFD1_ENST00000219638.4_Missense_Mutation_p.Q396H|UBFD1_ENST00000567212.1_Missense_Mutation_p.Q163H	NM_019116.2	NP_061989.2	O14562	UBFD1_HUMAN	ubiquitin family domain containing 1	172										endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7				GBM - Glioblastoma multiforme(48;0.0331)		CTGCGCAGCAGGATGCAAAGG	0.478000													23	1					3.08376e-08	3.41574e-08	0.279207	1	0
TNN	63923	broad.mit.edu	37	1	175097746	175097746	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:175097746C>A	ENST00000239462.4	+	15	3307	c.3194C>A	c.(3193-3195)cCa>cAa	p.P1065Q		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1065	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCCCGTTTCCCACACCCTTCG	0.542000													57	225					6.26901e-30	9.34768e-30	0.323286	1	0
ALPP	250	broad.mit.edu	37	2	233244940	233244940	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:233244940C>A	ENST00000392027.2	+	6	971	c.702C>A	c.(700-702)acC>acA	p.T234T	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	234						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GCATGGGAACCCCAGACCCTG	0.627000													29	204					2.75727e-19	3.65082e-19	0.214465	1	0
MN1	4330	broad.mit.edu	37	22	28194147	28194147	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:28194147C>A	ENST00000302326.4	-	1	3339	c.2385G>T	c.(2383-2385)caG>caT	p.Q795H		NM_002430.2	NP_002421.3	Q10571	MN1_HUMAN	meningioma (disrupted in balanced translocation) 1	795							binding			NS(1)|breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	45						CCGAGGTGCGCTGGCTGGGCT	0.701000			T	ETV6	"""AML, meningioma"""								12	2					7.03913e-09	7.85309e-09	0.093190	1	0
WFDC12	128488	broad.mit.edu	37	20	43752871	43752871	+	Missense_Mutation	SNP	C	C	A	rs148261601	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:43752871C>A	ENST00000372785.3	-	2	132	c.115G>T	c.(115-117)Gta>Tta	p.V39L		NM_080869.1	NP_543145.1	Q8WWY7	WFD12_HUMAN	WAP four-disulfide core domain 12	39	WAP.				defense response to bacterium	extracellular region	serine-type endopeptidase inhibitor activity			endometrium(1)|large_intestine(2)|lung(2)|skin(1)	6		Myeloproliferative disorder(115;0.0122)				AAGCAGCGTACGTTGTCAGCT	0.552000													37	133					2.51541e-25	3.58997e-25	0.214465	1	0
COL3A1	1281	broad.mit.edu	37	2	189856420	189856420	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:189856420G>T	ENST00000304636.3	+	13	1093	c.923G>T	c.(922-924)cGa>cTa	p.R308L	COL3A1_ENST00000317840.5_Missense_Mutation_p.R308L	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	308	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding	p.A304_G309delAPGERG(1)		NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCTGGTGAGCGAGGACGGCCA	0.463000													78	88					7.62712e-44	1.25444e-43	0.323286	1	0
REL	5966	broad.mit.edu	37	2	61149451	61149451	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:61149451C>A	ENST00000295025.7	+	11	1961	c.1641C>A	c.(1639-1641)ggC>ggA	p.G547G	REL_ENST00000394479.3_Silent_p.G515G	NM_002908.2	NP_002899.1	Q04864	REL_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog	547					positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(3)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	16	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			TGTCAGCAGGCGCCAATTCCA	0.428000			A		Hodgkin Lymphoma								71	153					1.91593e-42	3.12626e-42	0.323286	1	0
IQGAP2	10788	broad.mit.edu	37	5	75932931	75932931	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:75932931A>C	ENST00000274364.6	+	16	2150	c.1853A>C	c.(1852-1854)aAa>aCa	p.K618T	IQGAP2_ENST00000379730.3_Missense_Mutation_p.K177T|IQGAP2_ENST00000396234.3_Missense_Mutation_p.K171T|IQGAP2_ENST00000502745.1_Missense_Mutation_p.K171T	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	618	WW.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		ACTGATTCAAAAGAGAGTTCC	0.378000													12	82					0	0	0.119110	0	0
FAT2	2196	broad.mit.edu	37	5	150934205	150934205	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:150934205T>C	ENST00000261800.5	-	4	3675	c.3663A>G	c.(3661-3663)tcA>tcG	p.S1221S		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1221	Cadherin 10.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGACTTCAGTGAGGGTTCCC	0.507000													75	86					0	0	0.323286	0	0
SPOCK3	50859	broad.mit.edu	37	4	167675843	167675843	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:167675843T>A	ENST00000357154.3	-	9	893	c.756A>T	c.(754-756)tcA>tcT	p.S252S	SPOCK3_ENST00000535728.1_Silent_p.S120S|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000502330.1_Silent_p.S252S|SPOCK3_ENST00000534949.1_Silent_p.S156S|SPOCK3_ENST00000510741.1_Silent_p.S209S|SPOCK3_ENST00000357545.4_Silent_p.S249S|SPOCK3_ENST00000541637.1_Silent_p.S154S|SPOCK3_ENST00000512648.1_Silent_p.S249S|SPOCK3_ENST00000421836.2_Silent_p.S201S|SPOCK3_ENST00000512681.1_Silent_p.S154S|SPOCK3_ENST00000506886.1_Silent_p.S252S|SPOCK3_ENST00000511531.1_Silent_p.S252S|SPOCK3_ENST00000504953.1_Silent_p.S249S|SPOCK3_ENST00000511269.1_Silent_p.S249S|SPOCK3_ENST00000541354.1_Silent_p.S132S	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	252					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		TCCAGCCAAGTGAGTCCTTGC	0.373000													18	61					0	0	0.204396	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84534615	84534615	+	RNA	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:84534615C>G	ENST00000527857.1	+	0	4637					NR_026851.1																						CCAATCCATGCCCCACAGGGA	0.493000													15	7					0	0	0.132662	0	0
DSG1	1828	broad.mit.edu	37	18	28934679	28934679	+	Silent	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:28934679T>G	ENST00000257192.4	+	15	2732	c.2520T>G	c.(2518-2520)tcT>tcG	p.S840S	RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA|DSG1_ENST00000462981.2_Silent_p.S199S	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	840					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TGACCGAGTCTTACACCACCT	0.522000													19	541					0	0	0.219247	0	0
MUC16	94025	broad.mit.edu	37	19	9069244	9069244	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:9069244T>C	ENST00000397910.4	-	3	18405	c.18202A>G	c.(18202-18204)Aga>Gga	p.R6068G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6070	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTTGAGTCTCTGTCAACATTT	0.483000													91	225					0	0	0.323286	0	0
AHR	196	broad.mit.edu	37	7	17379180	17379180	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:17379180A>T	ENST00000242057.4	+	10	2374	c.1731A>T	c.(1729-1731)ttA>ttT	p.L577F		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	577					apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ACATTGACTTAACGGATGAAA	0.378000													53	159					0	0	0.323286	0	0
PLCB2	5330	broad.mit.edu	37	15	40591414	40591414	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:40591414G>T	ENST00000260402.3	-	8	847	c.598C>A	c.(598-600)Cct>Act	p.P200T	PLCB2_ENST00000456256.2_Missense_Mutation_p.P200T|PLCB2_ENST00000557821.1_Missense_Mutation_p.P200T	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	200					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		AAGTCCTCAGGATTGATGGCG	0.507000													55	12					1.12612e-26	1.62591e-26	0.323286	1	0
MYOCD	93649	broad.mit.edu	37	17	12666919	12666919	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:12666919C>A	ENST00000425538.1	+	14	3119	c.2919C>A	c.(2917-2919)ctC>ctA	p.L973L	MYOCD_ENST00000343344.4_Silent_p.L925L|RP11-1090M7.1_ENST00000584772.1_RNA	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	925					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TCACTGATCTCAATTTGAATT	0.522000													77	10					6.0678e-26	8.69998e-26	0.323286	1	0
KCNS3	3790	broad.mit.edu	37	2	18112326	18112326	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:18112326C>A	ENST00000403915.1	+	3	502	c.51C>A	c.(49-51)gtC>gtA	p.V17V	KCNS3_ENST00000304101.4_Silent_p.V17V|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	17					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					AGGAACTTGTCAACCTGAATG	0.527000													97	114					1.90545e-35	2.98341e-35	0.323286	1	0
DYNC2LI1	51626	broad.mit.edu	37	2	44028817	44028817	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:44028817C>A	ENST00000260605.8	+	10	871	c.771C>A	c.(769-771)atC>atA	p.I257I	DYNC2LI1_ENST00000605786.1_Silent_p.I258I|DYNC2LI1_ENST00000443170.3_Silent_p.I131I	NM_001193464.1|NM_016008.3	NP_001180393.1|NP_057092.2	Q8TCX1	DC2L1_HUMAN	dynein, cytoplasmic 2, light intermediate chain 1	257						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|skin(1)	26		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CGCTGTTTATCACAGCAGGAT	0.348000													26	33					6.04164e-23	8.42078e-23	0.153744	1	0
PDCD11	22984	broad.mit.edu	37	10	105198552	105198552	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:105198552G>C	ENST00000369797.3	+	27	4106	c.4012G>C	c.(4012-4014)Ggt>Cgt	p.G1338R		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	1338	S1 motif 12.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding	p.G1338C(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CCAGCCACACGGTGTGTTCTT	0.552000													14	28					0	0	0.309145	0	0
KALRN	8997	broad.mit.edu	37	3	124376392	124376392	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:124376392A>C	ENST00000360013.3	+	40	6084	c.5957A>C	c.(5956-5958)cAt>cCt	p.H1986P	KALRN_ENST00000393496.1_Missense_Mutation_p.H327P|KALRN_ENST00000428018.2_Missense_Mutation_p.H257P|KALRN_ENST00000291478.4_Missense_Mutation_p.H289P|KALRN_ENST00000459915.1_Missense_Mutation_p.H78P	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	1985	DH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TATGACTGGCATAAGGAGTAA	0.473000													36	83					0	0	0.203993	0	0
KIAA0355	9710	broad.mit.edu	37	19	34832328	34832328	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:34832328G>T	ENST00000299505.6	+	10	2362	c.1487_splice	c.e10-1	p.E497_splice		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	497										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					TTTAAATAGGGAGCAAGCTTT	0.358000													31	151					1.80694e-10	2.08111e-10	0.144211	1	0
SLC38A6	145389	broad.mit.edu	37	14	61512086	61512086	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:61512086T>G	ENST00000354886.2	+	11	931	c.767T>G	c.(766-768)aTg>aGg	p.M256R	SLC38A6_ENST00000456840.2_Missense_Mutation_p.M233R|SLC38A6_ENST00000267488.4_Missense_Mutation_p.M256R	NM_001172702.1	NP_001166173.1	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	256					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TTACCAACCATGGCTTTTTCA	0.318000													40	35					0	0	0.301197	0	0
KCNA5	3741	broad.mit.edu	37	12	5153858	5153858	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:5153858G>T	ENST00000252321.3	+	1	774	c.545G>T	c.(544-546)gGg>gTg	p.G182V		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	182						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TACCAGTCCGGGGGCCGCCTG	0.657000													20	48					7.05121e-23	9.81465e-23	0.290176	1	0
ARHGEF25	115557	broad.mit.edu	37	12	58010136	58010136	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:58010136C>G	ENST00000286494.4	+	14	1950	c.1490C>G	c.(1489-1491)cCt>cGt	p.P497R	ARHGEF25_ENST00000333972.7_Missense_Mutation_p.P536R|AC025165.8_ENST00000593846.1_RNA|AC025165.8_ENST00000356672.3_RNA|AC025165.8_ENST00000444467.1_RNA	NM_182947.3	NP_891992.2	Q86VW2	ARHGP_HUMAN	Rho guanine nucleotide exchange factor (GEF) 25	497					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	28						CCAAGAGGGCCTGGAGTGGGG	0.597000													40	80					0	0	0.268233	0	0
SCN3A	6328	broad.mit.edu	37	2	165948901	165948901	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:165948901A>C	ENST00000360093.3	-	27	5161	c.4670T>G	c.(4669-4671)gTt>gGt	p.V1557G	SCN3A_ENST00000283254.7_Missense_Mutation_p.V1557G|SCN3A_ENST00000540861.1_Missense_Mutation_p.V40G|SCN3A_ENST00000465043.1_5'UTR|SCN3A_ENST00000409101.3_Missense_Mutation_p.V1508G	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1557						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CCGGGACAAAACTAGGGTCAT	0.463000													9	141					0	0	0.069234	0	0
B4GALNT2	124872	broad.mit.edu	37	17	47247031	47247031	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:47247031C>A	ENST00000300404.2	+	11	1701	c.1642C>A	c.(1642-1644)Cgg>Agg	p.R548R	B4GALNT2_ENST00000504681.1_Silent_p.R462R|B4GALNT2_ENST00000393354.2_Silent_p.R488R	NM_153446.2	NP_703147.2	Q8NHY0	B4GN2_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 2	548					lipid glycosylation|negative regulation of cell-cell adhesion|UDP-N-acetylgalactosamine metabolic process	integral to Golgi membrane	acetylgalactosaminyltransferase activity			endometrium(3)|large_intestine(6)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	24			all cancers(6;0.000316)			CACCCTCACCCGGGTCCAGTT	0.522000													19	29					2.98393e-07	3.2574e-07	0.264190	1	0
ESYT1	23344	broad.mit.edu	37	12	56531639	56531639	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:56531639C>G	ENST00000394048.5	+	19	2403	c.2139C>G	c.(2137-2139)ggC>ggG	p.G713G	ESYT1_ENST00000541590.1_Silent_p.G723G|ESYT1_ENST00000267113.4_Silent_p.G723G	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	713	C2 3.					integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						CAGTTCCAGGCCAAGAGCTAG	0.483000													81	197					0	0	0.323286	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450166	105450166	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:105450166G>T	ENST00000337685.2	+	5	1526	c.741G>T	c.(739-741)atG>atT	p.M247I	MUM1L1_ENST00000372552.1_Missense_Mutation_p.M247I|MUM1L1_ENST00000357175.2_Missense_Mutation_p.M247I	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	247										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						CATCAGATATGCTCATTATGC	0.443000													32	5					2.87052e-16	3.64643e-16	0.225048	1	0
FOXP2	93986	broad.mit.edu	37	7	114268649	114268649	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:114268649C>A	ENST00000393500.3	+	9	857	c.37C>A	c.(37-39)Cag>Aag	p.Q13K	FOXP2_ENST00000393498.2_Missense_Mutation_p.Q105K|FOXP2_ENST00000393489.3_Missense_Mutation_p.Q13K|FOXP2_ENST00000393491.3_Missense_Mutation_p.Q13K|FOXP2_ENST00000459666.1_3'UTR|FOXP2_ENST00000408937.3_Missense_Mutation_p.Q130K|FOXP2_ENST00000350908.4_Missense_Mutation_p.Q105K|FOXP2_ENST00000390668.3_Missense_Mutation_p.Q129K|FOXP2_ENST00000360232.4_Missense_Mutation_p.Q105K|FOXP2_ENST00000393494.2_Missense_Mutation_p.Q105K|FOXP2_ENST00000403559.4_Missense_Mutation_p.Q105K|FOXP2_ENST00000378237.3_Missense_Mutation_p.Q105K			O15409	FOXP2_HUMAN	forkhead box P2	105					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						TCAGCAAATGCAGCAGATCCT	0.507000													56	199					1.69475e-38	2.70968e-38	0.323286	1	0
CCDC168	643677	broad.mit.edu	37	13	103386695	103386695	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:103386695C>A	ENST00000322527.2	-	1	2464	c.2465G>T	c.(2464-2466)aGg>aTg	p.R822M		NM_001146197.1	NP_001139669.1			coiled-coil domain containing 168																		ACCTCCAAGCCTTTCTTCATC	0.423000													4	13					0.00024832	0.000259638	0.150653	1	0
TRBV24-1	28563	broad.mit.edu	37	7	142364628	142364628	+	RNA	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142364628A>T	ENST00000390397.2	+	0	299																											GTCTCTCGACAGGCACAGGCT	0.488000													97	296					0	0	0.323286	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607853	84607853	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:84607853A>G	ENST00000344803.2	+	4	2515	c.2468A>G	c.(2467-2469)cAg>cGg	p.Q823R		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AGACTAGGTCAGAAACAACTT	0.453000													99	73					0	0	0.323286	0	0
GALNT13	114805	broad.mit.edu	37	2	155157959	155157959	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:155157959G>T	ENST00000392825.3	+	9	1580	c.1013G>T	c.(1012-1014)tGc>tTc	p.C338F	GALNT13_ENST00000409237.1_Missense_Mutation_p.C338F|GALNT13_ENST00000487047.1_3'UTR	NM_052917.2	NP_443149.2	Q8IUC8	GLT13_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)	338	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|lung(37)|ovary(3)|pancreas(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	65						ATTGTTACTTGCTCCCATGTT	0.418000													61	185					3.00063e-23	4.19357e-23	0.323286	1	0
ABCA12	26154	broad.mit.edu	37	2	215819926	215819926	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:215819926C>A	ENST00000272895.7	-	43	6612	c.6393_splice	c.e43+1	p.P2131_splice	ABCA12_ENST00000389661.4_Splice_Site_p.P1813_splice|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2131					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GGGACCTTACCGGATCATTAG	0.338000													39	57					5.20006e-24	7.3236e-24	0.301197	1	0
SSX5	6758	broad.mit.edu	37	X	48047126	48047126	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:48047126C>A	ENST00000311798.1	-	8	683	c.631G>T	c.(631-633)Gag>Tag	p.E211*	SSX5_ENST00000376923.1_Nonsense_Mutation_p.E170*|SSX5_ENST00000347757.1_Nonsense_Mutation_p.E170*	NM_021015.3	NP_066295.3	O60225	SSX5_HUMAN	synovial sarcoma, X breakpoint 5	170					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding	p.E211Q(1)		endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|skin(1)	18						TGCTTTCTCTCACGCACTCTG	0.498000													157	211					6.75762e-91	1.22603e-90	0.323286	1	0
ELAC1	55520	broad.mit.edu	37	18	48513120	48513120	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:48513120G>T	ENST00000269466.3	+	4	864	c.757G>T	c.(757-759)Gac>Tac	p.D253Y	RP11-729L2.2_ENST00000588256.1_Intron|SMAD4_ENST00000452201.2_Intron|RP11-729L2.2_ENST00000590722.2_Intron|ELAC1_ENST00000588577.1_3'UTR	NM_018696.2	NP_061166.1	Q9H777	RNZ1_HUMAN	elaC ribonuclease Z 1	253					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			kidney(1)|large_intestine(4)|prostate(1)	6		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		CATATTGGGTGACTGCTCTGG	0.438000													55	32					6.81593e-30	1.01583e-29	0.323286	1	0
AGL	178	broad.mit.edu	37	1	100382214	100382214	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:100382214G>T	ENST00000294724.4	+	33	4886	c.4408G>T	c.(4408-4410)Ggc>Tgc	p.G1470C	AGL_ENST00000370161.2_Missense_Mutation_p.G1454C|AGL_ENST00000370165.3_Missense_Mutation_p.G1470C|AGL_ENST00000361522.4_Missense_Mutation_p.G1453C|AGL_ENST00000361302.3_Missense_Mutation_p.G1454C|AGL_ENST00000370163.3_Missense_Mutation_p.G1470C|AGL_ENST00000361915.3_Missense_Mutation_p.G1470C	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	1470					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		CAGATTGATGGGCCCGGAGAC	0.348000													23	40					2.21704e-12	2.64592e-12	0.264190	1	0
TFEC	22797	broad.mit.edu	37	7	115580862	115580862	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:115580862G>T	ENST00000265440.7	-	8	967	c.787C>A	c.(787-789)Caa>Aaa	p.Q263K	TFEC_ENST00000457268.1_Missense_Mutation_p.Q196K|TFEC_ENST00000393485.1_3'UTR|TFEC_ENST00000320239.7_Missense_Mutation_p.Q234K	NM_012252.3	NP_036384.1	O14948	TFEC_HUMAN	transcription factor EC	263						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			GTCAGTTGTTGGCAATAGTCT	0.473000													90	197					8.64784e-51	1.46272e-50	0.323286	1	0
DCDC1	341019	broad.mit.edu	37	11	31327937	31327937	+	Splice_Site	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:31327937T>A	ENST00000597505.1	-	3	434		c.e3-2		DCDC1_ENST00000452803.1_Splice_Site|RP1-296L11.1_ENST00000528872.1_RNA			P59894	DCDC1_HUMAN	doublecortin domain containing 1						intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					TCTGCAACCCTGAAGAAAAAG	0.318000													69	3					0	0	0.323286	0	0
HSD11B1	3290	broad.mit.edu	37	1	209879155	209879155	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:209879155G>T	ENST00000367028.2	+	3	257		c.e3-1		HSD11B1_ENST00000367027.3_Splice_Site|HSD11B1_ENST00000261465.1_Splice_Site|RP1-28O10.1_ENST00000441672.1_RNA	NM_001206741.1	NP_001193670.1	P28845	DHI1_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1						glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	16				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	GGGTTCCCCAGAGATGCTCCA	0.488000													211	80					7.02639e-97	1.27929e-96	0.323286	1	0
ANO2	57101	broad.mit.edu	37	12	5685159	5685159	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:5685159G>T	ENST00000327087.8	-	24	2533	c.2462C>A	c.(2461-2463)tCc>tAc	p.S821Y	ANO2_ENST00000546188.1_Missense_Mutation_p.S822Y|ANO2_ENST00000356134.5_Missense_Mutation_p.S822Y			Q9NQ90	ANO2_HUMAN	anoctamin 2	826						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						GATAAAGTCGGAGGTGATCGC	0.517000													22	5					4.26978e-12	5.07036e-12	0.279207	1	0
PXDNL	137902	broad.mit.edu	37	8	52323922	52323922	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:52323922C>A	ENST00000356297.4	-	16	2050	c.1950G>T	c.(1948-1950)ccG>ccT	p.P650P	PXDNL_ENST00000543296.1_Silent_p.P650P	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	650					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.P650P(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				GTGGGTCACGCGGGTAATGAA	0.493000													11	19					9.31168e-06	9.94423e-06	0.105934	1	0
SH3BP2	6452	broad.mit.edu	37	4	2822418	2822418	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:2822418G>T	ENST00000356331.5	+	2	335	c.74G>T	c.(73-75)gGg>gTg	p.G25V	SH3BP2_ENST00000442312.2_Missense_Mutation_p.G53V|SH3BP2_ENST00000435136.2_Missense_Mutation_p.G25V|SH3BP2_ENST00000389838.2_Missense_Mutation_p.G25V|SH3BP2_ENST00000503393.2_Missense_Mutation_p.G82V|SH3BP2_ENST00000511747.1_Missense_Mutation_p.G25V|SH3BP2_ENST00000452765.2_Missense_Mutation_p.G25V	NM_003023.4	NP_003014.3	P78314	3BP2_HUMAN	SH3-domain binding protein 2	25					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		ACCATGCCTGGGGGCGTGGCC	0.592000									Cherubism				47	56					9.59835e-30	1.42708e-29	0.323286	1	0
CAD	790	broad.mit.edu	37	2	27446888	27446888	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:27446888G>T	ENST00000264705.4	+	8	1261	c.1099G>T	c.(1099-1101)Ggc>Tgc	p.G367C	CAD_ENST00000403525.1_Missense_Mutation_p.G367C	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	367	Linker.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GAACCCTGGGGGCCAGACAGG	0.537000													14	112					1.49906e-05	1.59102e-05	0.119110	1	0
PRUNE2	158471	broad.mit.edu	37	9	79328503	79328503	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:79328503T>C	ENST00000376718.3	-	7	1014	c.891A>G	c.(889-891)tcA>tcG	p.S297S	PRUNE2_ENST00000428286.1_5'UTR	NM_015225.2	NP_056040.2	Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	297					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CCATGTTTTCTGAGTACACAG	0.512000													14	15					0	0	0.189662	0	0
OR2J3	442186	broad.mit.edu	37	6	29080006	29080006	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:29080006A>T	ENST00000377169.1	+	1	339	c.339A>T	c.(337-339)acA>acT	p.T113T		NM_001005216.2	NP_001005216.2	O76001	OR2J3_HUMAN	olfactory receptor, family 2, subfamily J, member 3	113			T -> A (in allele 6M1-3*02; dbSNP:rs28757581).		sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	24						TGGGAACCACAGAGTGTGTCC	0.502000													173	416					0	0	0.323286	0	0
UBQLN3	50613	broad.mit.edu	37	11	5530706	5530706	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:5530706G>T	ENST00000311659.4	-	2	230	c.83C>A	c.(82-84)aCg>aAg	p.T28K	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	28	Ubiquitin-like.									NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCTTTGGGCGTCTTCACTGT	0.567000													53	27					9.22156e-22	1.26368e-21	0.323286	1	0
AP3S1	1176	broad.mit.edu	37	5	115205762	115205762	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:115205762G>T	ENST00000316788.7	+	3	767	c.210G>T	c.(208-210)acG>acT	p.T70T		NM_001284.2	NP_001275.1	Q92572	AP3S1_HUMAN	adaptor-related protein complex 3, sigma 1 subunit	70					insulin receptor signaling pathway|intracellular protein transport|vesicle-mediated transport	AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|Golgi apparatus|transport vesicle	protein binding|protein transporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)	12		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;1.08e-07)|Epithelial(69;1.11e-06)|all cancers(49;5.2e-05)		ATTATGCAACGTTATATTTTG	0.284000													28	60					5.45727e-16	6.90971e-16	0.134883	1	0
EDIL3	10085	broad.mit.edu	37	5	83259139	83259139	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:83259139G>T	ENST00000296591.5	-	10	1596	c.1178C>A	c.(1177-1179)aCa>aAa	p.T393K	EDIL3_ENST00000380138.3_Missense_Mutation_p.T383K	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	393	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		AGCTCCTTGTGTAATGATGCC	0.393000													40	50					4.67007e-22	6.42238e-22	0.268233	1	0
LAMA2	3908	broad.mit.edu	37	6	129601214	129601214	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:129601214C>G	ENST00000421865.2	+	18	2508	c.2459C>G	c.(2458-2460)cCa>cGa	p.P820R		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	820	Laminin EGF-like 7.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGCTTTAGCCCAACGTGCCAT	0.463000													55	53					0	0	0.323286	0	0
SMPD1	6609	broad.mit.edu	37	11	6412057	6412057	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:6412057G>T	ENST00000342245.4	+	1	397	c.229G>T	c.(229-231)Gtg>Ttg	p.V77L	SMPD1_ENST00000299397.3_Missense_Mutation_p.V77L|SMPD1_ENST00000527275.1_Missense_Mutation_p.V77L|SMPD1_ENST00000356761.2_Missense_Mutation_p.V77L|SMPD1_ENST00000533196.1_Intron	NM_000543.4|NM_001007593.2	NP_000534.3|NP_001007594.2	P17405	ASM_HUMAN	sphingomyelin phosphodiesterase 1, acid lysosomal	75					cell death|ceramide biosynthetic process|negative regulation of MAP kinase activity|nervous system development|positive regulation of protein dephosphorylation|signal transduction|sphingomyelin catabolic process|termination of signal transduction	lysosome	hydrolase activity, acting on glycosyl bonds|sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(3)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;4.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)	Desipramine(DB01151)	ACATCGCATAGTGCCCCGGCT	0.612000													104	85					2.12867e-53	3.64226e-53	0.323286	1	0
SNHG14	104472715	broad.mit.edu	37	15	25346733	25346733	+	RNA	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:25346733G>C	ENST00000546682.1	+	0	1475				SNHG14_ENST00000553108.1_RNA|SNORD116-27_ENST00000516087.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						GATCGATGATGACTTAAAGAT	0.433000													27	31					0	0	0.116897	0	0
GRM2	2912	broad.mit.edu	37	3	51749542	51749542	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:51749542G>A	ENST00000395052.3	+	4	1987	c.1753G>A	c.(1753-1755)Gtg>Atg	p.V585M	GRM2_ENST00000475478.1_3'UTR|GRM2_ENST00000442933.2_Intron	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	585					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CACCCTCTTTGTGCTGGGTGT	0.627000													12	94					0	0	0.105934	0	0
BTRC	8945	broad.mit.edu	37	10	103294633	103294633	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:103294633A>T	ENST00000370187.3	+	10	1431	c.1313A>T	c.(1312-1314)tAc>tTc	p.Y438F	BTRC_ENST00000408038.2_Missense_Mutation_p.Y402F|BTRC_ENST00000393441.4_Missense_Mutation_p.Y397F	NM_033637.3	NP_378663.1	Q9Y297	FBW1A_HUMAN	beta-transducin repeat containing E3 ubiquitin protein ligase	438					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|positive regulation of proteolysis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|viral reproduction|Wnt receptor signaling pathway	cytosol|nucleus|SCF ubiquitin ligase complex				endometrium(4)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	27		Colorectal(252;0.234)		Epithelial(162;1.05e-08)|all cancers(201;6.59e-07)		GATGACAAGTACATTGTTTCT	0.423000													68	81					0	0	0.323286	0	0
MYH2	4620	broad.mit.edu	37	17	10432993	10432993	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:10432993T>G	ENST00000245503.5	-	24	3389	c.3005A>C	c.(3004-3006)aAg>aCg	p.K1002T	MYH2_ENST00000397183.2_Missense_Mutation_p.K1002T|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1002					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GAGAGCCTTCTTCTCCTTGGT	0.473000													14	78					0	0	0.160694	0	0
FLNC	2318	broad.mit.edu	37	7	128481269	128481269	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:128481269A>G	ENST00000325888.8	+	12	2120	c.1859A>G	c.(1858-1860)gAc>gGc	p.D620G	FLNC_ENST00000346177.6_Missense_Mutation_p.D620G	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	620					cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GAATGTGACGACAAGGGGGAT	0.627000													21	98					0	0	0.279207	0	0
NRXN1	9378	broad.mit.edu	37	2	51255088	51255088	+	Silent	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:51255088C>G	ENST00000404971.1	-	2	1663	c.324G>C	c.(322-324)ccG>ccC	p.P108P	NRXN1_ENST00000402717.3_Silent_p.P108P|NRXN1_ENST00000406316.2_Silent_p.P108P|NRXN1_ENST00000405472.3_Silent_p.P108P|NRXN1_ENST00000401669.2_Silent_p.P108P|NRXN1_ENST00000406859.3_Silent_p.P108P|NRXN1_ENST00000405581.1_Silent_p.P108P	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	108	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CGTCGTTAACCGGCGTGTCGG	0.657000													9	6					0	0	0.093190	0	0
MYH8	4626	broad.mit.edu	37	17	10302183	10302183	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:10302183C>A	ENST00000403437.2	-	29	3977	c.3883G>T	c.(3883-3885)Gat>Tat	p.D1295Y	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1295					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						TCTTTCTCATCTAATTGTCGA	0.348000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				53	6					9.59835e-30	1.42708e-29	0.323286	1	0
OR2L3	391192	broad.mit.edu	37	1	248224541	248224541	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248224541G>C	ENST00000359959.3	+	1	558	c.558G>C	c.(556-558)ctG>ctC	p.L186L	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			TGGTGACTCTGGCCTGCATGG	0.473000													12	205					0	0	0.264190	0	0
PLXDC2	84898	broad.mit.edu	37	10	20506404	20506404	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:20506404G>C	ENST00000377252.3	+	11	2013	c.1172G>C	c.(1171-1173)cGa>cCa	p.R391P	PLXDC2_ENST00000377238.2_3'UTR|PLXDC2_ENST00000377242.3_Missense_Mutation_p.R342P	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	391	Thr-rich.					integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						ACTTCTTCTCGAACCACCACA	0.443000													63	189					0	0	0.323286	0	0
MYO7B	4648	broad.mit.edu	37	2	128341865	128341865	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:128341865G>T	ENST00000389524.4	+	13	1565	c.1512G>T	c.(1510-1512)atG>atT	p.M504I	MYO7B_ENST00000428314.1_Missense_Mutation_p.M504I|MYO7B_ENST00000409816.2_Missense_Mutation_p.M504I			Q6PIF6	MYO7B_HUMAN	myosin VIIB	504	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		TCAAGCCCATGAGCATCATCT	0.607000													31	12					6.53348e-20	8.72915e-20	0.193644	1	0
IPO13	9670	broad.mit.edu	37	1	44432217	44432217	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:44432217G>T	ENST00000372339.3	+	1	607	c.22G>T	c.(22-24)Ggc>Tgc	p.G8C	IPO13_ENST00000372343.3_Intron			O94829	IPO13_HUMAN	importin 13	0					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				AGCTGGCTGGGGCTGGGCTTA	0.582000													8	12					1.12685e-05	1.20009e-05	0.307466	1	0
GRAMD1B	57476	broad.mit.edu	37	11	123485468	123485468	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:123485468G>T	ENST00000529750.1	+	16	2141	c.1814G>T	c.(1813-1815)cGg>cTg	p.R605L	GRAMD1B_ENST00000450171.2_Missense_Mutation_p.R296L|GRAMD1B_ENST00000322282.7_Missense_Mutation_p.R605L|GRAMD1B_ENST00000456860.2_Missense_Mutation_p.R612L	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	605						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		ACACAGACGCGGCATATCCCG	0.532000													38	85					5.73435e-26	8.2257e-26	0.323286	1	0
XIRP2	129446	broad.mit.edu	37	2	168103170	168103170	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:168103170T>G	ENST00000409195.1	+	9	5357	c.5268T>G	c.(5266-5268)gaT>gaG	p.D1756E	XIRP2_ENST00000295237.9_Missense_Mutation_p.D1756E|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D1534E	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1581					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAGCTTTGGATTATCTGAAAC	0.383000													100	195					0	0	0.323286	0	0
PARD3B	117583	broad.mit.edu	37	2	206166423	206166423	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:206166423G>A	ENST00000406610.2	+	18	2835	c.2628G>A	c.(2626-2628)ctG>ctA	p.L876L	PARD3B_ENST00000351153.1_Silent_p.L807L|PARD3B_ENST00000462231.1_Silent_p.L876L|PARD3B_ENST00000358768.2_Silent_p.L814L|PARD3B_ENST00000349953.3_Silent_p.L876L	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	876	Lys-rich.				cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		GCGCCATGCTGAGGTATGGGC	0.433000													35	109					0	0	0.214465	0	0
CNOT10	25904	broad.mit.edu	37	3	32761609	32761609	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:32761609G>T	ENST00000328834.5	+	8	1064	c.748G>T	c.(748-750)Gca>Tca	p.A250S	CNOT10_ENST00000538368.1_Missense_Mutation_p.A22S|CNOT10_ENST00000331889.6_Missense_Mutation_p.A250S|CNOT10_ENST00000454516.2_Missense_Mutation_p.A310S|CNOT10_ENST00000463697.1_3'UTR	NM_015442.2	NP_056257.1	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	250					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(3)	23						TCTACAGTCCGCACCCTCTCT	0.333000													29	69					2.47511e-08	2.74451e-08	0.134883	1	0
PCDH19	57526	broad.mit.edu	37	X	99551726	99551726	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:99551726G>T	ENST00000373034.4	-	6	4671	c.2996C>A	c.(2995-2997)gCt>gAt	p.A999D	PCDH19_ENST00000420881.2_Missense_Mutation_p.A951D|PCDH19_ENST00000255531.7_Missense_Mutation_p.A952D	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	999					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						GACATCAGCAGCAGTAGCTTC	0.582000													89	12					8.16033e-55	1.40403e-54	0.323286	1	0
LY9	4063	broad.mit.edu	37	1	160783596	160783596	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:160783596G>C	ENST00000263285.5	+	3	655	c.625G>C	c.(625-627)Gtc>Ctc	p.V209L	LY9_ENST00000471816.1_3'UTR|LY9_ENST00000341032.4_Missense_Mutation_p.V209L|LY9_ENST00000368041.2_Missense_Mutation_p.V169L|LY9_ENST00000368040.1_5'UTR	NM_001261456.1|NM_002348.3	NP_001248385.1|NP_002339.2	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9	209	Ig-like C2-type 1.				cell adhesion|immunoglobulin mediated immune response	integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CATTCTTACCGTCTCCCGAAC	0.562000													80	198					0	0	0.323286	0	0
GRK7	131890	broad.mit.edu	37	3	141497196	141497196	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:141497196G>T	ENST00000264952.2	+	1	207	c.70G>T	c.(70-72)Gac>Tac	p.D24Y		NM_139209.2	NP_631948.1	Q8WTQ7	GRK7_HUMAN	G protein-coupled receptor kinase 7	24					visual perception	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	26						GAAGCCCTCGGACTGCGACAG	0.692000													16	31					1.64293e-13	2.00085e-13	0.279207	1	0
GATA4	2626	broad.mit.edu	37	8	11607661	11607661	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:11607661G>T	ENST00000335135.4	+	4	1383	c.825G>T	c.(823-825)caG>caT	p.Q275H	GATA4_ENST00000532059.1_Missense_Mutation_p.Q276H|GATA4_ENST00000528712.1_Missense_Mutation_p.Q69H	NM_002052.3	NP_002043.2	P43694	GATA4_HUMAN	GATA binding protein 4	275					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(10)	13	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		CCAACTGCCAGACCACCACCA	0.622000													12	4					1.40151e-16	1.78694e-16	0.219247	1	0
OR2F1	26211	broad.mit.edu	37	7	143657385	143657385	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:143657385G>T	ENST00000392899.1	+	1	359	c.322G>T	c.(322-324)Ggt>Tgt	p.G108C		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					CCTGGCCTTGGGTGGGATTGA	0.537000													107	321					1.49705e-65	2.64481e-65	0.323286	1	0
GALNT2	2590	broad.mit.edu	37	1	230339028	230339028	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:230339028G>T	ENST00000366672.4	+	3	438	c.366G>T	c.(364-366)cgG>cgT	p.R122R	GALNT2_ENST00000543760.1_Silent_p.R84R|GALNT2_ENST00000541865.1_Silent_p.R32R	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	122					immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				CTGACACCCGGCATGACCAGT	0.537000													93	207					3.64038e-38	5.80847e-38	0.323286	1	0
CATSPERG	57828	broad.mit.edu	37	19	38857880	38857880	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:38857880C>A	ENST00000409235.3	+	23	2813	c.2698C>A	c.(2698-2700)Cgc>Agc	p.R900S	CATSPERG_ENST00000410018.1_Missense_Mutation_p.R860S|CATSPERG_ENST00000215069.4_3'UTR	NM_021185.4	NP_067008.3	Q6ZRH7	CTSRG_HUMAN	catsper channel auxiliary subunit gamma	900					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(13)|ovary(1)|pancreas(2)|prostate(6)|skin(3)|stomach(1)|urinary_tract(2)	40						GGAATACAGCCGCCTGAAGAA	0.572000													46	35					1.67753e-36	2.65066e-36	0.323286	1	0
TENM2	57451	broad.mit.edu	37	5	167643788	167643788	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:167643788A>C	ENST00000519204.1	+	21	3849	c.3731A>C	c.(3730-3732)aAg>aCg	p.K1244T	TENM2_ENST00000518659.1_Missense_Mutation_p.K1365T|TENM2_ENST00000520394.1_Missense_Mutation_p.K1126T|TENM2_ENST00000403607.2_Missense_Mutation_p.K1189T|TENM2_ENST00000545108.1_Missense_Mutation_p.K1364T					teneurin transmembrane protein 2																		GCAGTAGACAAGAATGGGCTC	0.522000													20	53					0	0	0.234183	0	0
CNTN1	1272	broad.mit.edu	37	12	41422924	41422924	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:41422924C>A	ENST00000551295.2	+	23	3000	c.2883C>A	c.(2881-2883)tcC>tcA	p.S961S	CNTN1_ENST00000347616.1_Silent_p.S961S|CNTN1_ENST00000348761.2_Silent_p.S950S	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	961	Fibronectin type-III 4.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				ACAAACACTCCATAGAAGTCC	0.438000													109	274					5.36192e-66	9.48365e-66	0.323286	1	0
PTPRN2	5799	broad.mit.edu	37	7	157874037	157874037	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:157874037C>G	ENST00000389413.3	-	10	1692	c.1589G>C	c.(1588-1590)aGc>aCc	p.S530T	PTPRN2_ENST00000389416.4_Missense_Mutation_p.S542T|PTPRN2_ENST00000389418.4_Missense_Mutation_p.S559T|PTPRN2_ENST00000404321.2_Missense_Mutation_p.S582T|PTPRN2_ENST00000409483.1_Missense_Mutation_p.S521T	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	559						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GACATTGGCGCTCACTTTGAA	0.502000													9	48					0	0	0.058154	0	0
FRG2B	441581	broad.mit.edu	37	10	135439016	135439016	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:135439016C>A	ENST00000443774.1	-	4	476	c.427G>T	c.(427-429)Gat>Tat	p.D143Y	FRG2B_ENST00000425520.1_Missense_Mutation_p.D142Y			Q96QU4	FRG2B_HUMAN	FSHD region gene 2 family, member B	142						nucleus				endometrium(2)|kidney(2)|lung(14)|ovary(1)|prostate(1)	20		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		TGGTGGGCATCACAGGTCTCC	0.517000													43	151					1.3268e-25	1.89797e-25	0.323286	1	0
CCL20	6364	broad.mit.edu	37	2	228681090	228681090	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:228681090C>T	ENST00000409189.3	+	3	326	c.256C>T	c.(256-258)Cgt>Tgt	p.R86C	CCL20_ENST00000358813.4_Missense_Mutation_p.R87C|CCL20_ENST00000473642.1_3'UTR	NM_001130046.1|NM_004591.2	NP_001123518.1|NP_004582.1	P78556	CCL20_HUMAN	chemokine (C-C motif) ligand 20	87					cell-cell signaling|chemotaxis|defense response to bacterium|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity			cervix(1)|lung(2)	3		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;7.3e-11)|all cancers(144;4.13e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		ATATATTGTGCGTCTCCTCAG	0.393000													27	84					0	0	0.173368	0	0
KLHL4	56062	broad.mit.edu	37	X	86877246	86877246	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:86877246C>A	ENST00000373119.4	+	5	1105	c.960C>A	c.(958-960)ttC>ttA	p.F320L	KLHL4_ENST00000373114.4_Missense_Mutation_p.F320L	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	320						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						ACCAAGAATTCCTCCTGCTTC	0.353000													16	21					1.52009e-12	1.81976e-12	0.132662	1	0
DNAH11	8701	broad.mit.edu	37	7	21760405	21760405	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:21760405A>G	ENST00000328843.6	+	45	7249	c.7218A>G	c.(7216-7218)aaA>aaG	p.K2406K	DNAH11_ENST00000409508.3_Silent_p.K2399K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2406					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ACAGCCCAAAAGAAGTTTATG	0.368000									Kartagener syndrome				4	93					0	0	0.150653	0	0
TASP1	55617	broad.mit.edu	37	20	13415754	13415754	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:13415754C>A	ENST00000337743.4	-	12	1153	c.1033G>T	c.(1033-1035)Gtc>Ttc	p.V345F	TASP1_ENST00000480436.1_5'UTR|TASP1_ENST00000539805.1_3'UTR	NM_017714.2	NP_060184.2	Q9H6P5	TASP1_HUMAN	taspase, threonine aspartase, 1	345					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(11)|liver(1)|lung(11)|stomach(2)|urinary_tract(2)	31						GAACGGAGGACAATCACTCCG	0.418000													31	4					6.84511e-11	7.95471e-11	0.183431	1	0
OR5H2	79310	broad.mit.edu	37	3	98001903	98001903	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:98001903C>G	ENST00000355273.2	+	1	172	c.172C>G	c.(172-174)Cca>Gca	p.P58A	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						CTGGAATGACCCACAACTTCA	0.418000													213	185					0	0	0.323286	0	0
SETX	23064	broad.mit.edu	37	9	135206758	135206758	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:135206758C>A	ENST00000372169.2	-	8	1098	c.916G>T	c.(916-918)Ggt>Tgt	p.G306C	SETX_ENST00000224140.5_Missense_Mutation_p.G306C|SETX_ENST00000393220.1_Missense_Mutation_p.G306C			Q7Z333	SETX_HUMAN	senataxin	306					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		ATAAGTTGACCCCAGACCTTA	0.428000													50	70					2.76378e-25	3.93537e-25	0.323286	1	0
MDGA2	161357	broad.mit.edu	37	14	47530529	47530529	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:47530529G>A	ENST00000426342.1	-	7	1300	c.554C>T	c.(553-555)aCg>aTg	p.T185M	MDGA2_ENST00000357362.3_Missense_Mutation_p.T185M|MDGA2_ENST00000439988.2_Missense_Mutation_p.T414M|MDGA2_ENST00000399232.2_Missense_Mutation_p.T483M	NM_182830.3	NP_878250.2	Q7Z553	MDGA2_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 2	414	Ig-like 2.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				breast(3)|endometrium(4)|kidney(2)|large_intestine(14)|lung(41)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(5)	76						ACATGTGTACGTCCCAAAATC	0.408000													58	206					0	0	0.323286	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125874333	125874333	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:125874333C>A	ENST00000393434.2	-	5	891	c.542G>T	c.(541-543)aGg>aTg	p.R181M	ALDH1L1_ENST00000452905.2_Intron|ALDH1L1_ENST00000393431.2_Missense_Mutation_p.R181M|ALDH1L1_ENST00000455064.2_Missense_Mutation_p.R6M|ALDH1L1_ENST00000472186.1_Missense_Mutation_p.R181M|ALDH1L1_ENST00000273450.3_Missense_Mutation_p.R191M|ALDH1L1_ENST00000413612.1_5'UTR	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	181	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	AGCGATCAGCCTCACGGCCTG	0.622000													23	18					1.36565e-18	1.78909e-18	0.264190	1	0
USH2A	7399	broad.mit.edu	37	1	216498811	216498811	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:216498811T>C	ENST00000366943.2	-	6	1365	c.979A>G	c.(979-981)Aca>Gca	p.T327A	USH2A_ENST00000307340.3_Missense_Mutation_p.T327A|USH2A_ENST00000366942.3_Missense_Mutation_p.T327A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	327	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTATCAGCTGTGTCTCCTGCA	0.488000										HNSCC(13;0.011)			38	126					0	0	0.268233	0	0
LMOD2	442721	broad.mit.edu	37	7	123303145	123303145	+	Nonsense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:123303145C>G	ENST00000458573.2	+	2	1662	c.1505C>G	c.(1504-1506)tCa>tGa	p.S502*	LMOD2_ENST00000456238.2_Nonsense_Mutation_p.S109*	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	502						cytoskeleton	actin binding|tropomyosin binding										TCTCTGAGGTCAGTGCAAGAG	0.408000													30	86					0	0	0.173368	0	0
SH3GL2	6456	broad.mit.edu	37	9	17791292	17791292	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:17791292G>T	ENST00000380607.4	+	7	808	c.688G>T	c.(688-690)Gtc>Ttc	p.V230F	SH3GL2_ENST00000537391.1_Missense_Mutation_p.V183F	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	230	BAR.				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		CAAGCAGGCAGTCCAGATCCT	0.428000													129	350					3.12418e-63	5.50374e-63	0.323286	1	0
KIAA1468	57614	broad.mit.edu	37	18	59933944	59933944	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:59933944A>T	ENST00000256858.6	+	19	2890	c.2642A>T	c.(2641-2643)cAg>cTg	p.Q881L	KIAA1468_ENST00000398130.2_Missense_Mutation_p.Q881L			Q9P260	K1468_HUMAN	KIAA1468	881							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				GTAAAACCTCAGTTCCAGGAG	0.308000													28	15					0	0	0.153744	0	0
ZNF804A	91752	broad.mit.edu	37	2	185803677	185803677	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:185803677C>A	ENST00000302277.6	+	4	4148	c.3554C>A	c.(3553-3555)cCa>cAa	p.P1185Q		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1185						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CTGGCTTTCCCATCTTTACCC	0.488000													159	298					3.84939e-54	6.61207e-54	0.323286	1	0
SLC26A4	5172	broad.mit.edu	37	7	107315473	107315473	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:107315473C>A	ENST00000265715.3	+	6	908	c.684C>A	c.(682-684)gcC>gcA	p.A228A		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	228					regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						CAGCTGCTGCCTTCCAAGTGC	0.423000									Pendred syndrome				73	257					1.76847e-28	2.60188e-28	0.323286	1	0
TESPA1	9840	broad.mit.edu	37	12	55359894	55359894	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55359894A>C	ENST00000449076.1	-	7	521	c.389T>G	c.(388-390)cTt>cGt	p.L130R	TESPA1_ENST00000531122.1_5'UTR|TESPA1_ENST00000524622.1_5'UTR|TESPA1_ENST00000532804.1_5'UTR|TESPA1_ENST00000524959.1_Intron|TESPA1_ENST00000316577.8_Missense_Mutation_p.L130R	NM_001136030.2	NP_001129502.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	130																	ACTACAGCCAAGATCAAGTAG	0.512000													25	62					0	0	0.225048	0	0
FMN2	56776	broad.mit.edu	37	1	240256720	240256720	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:240256720T>A	ENST00000319653.9	+	1	1541	c.1311T>A	c.(1309-1311)ccT>ccA	p.P437P		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	437					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CTCAGTCCCCTAATCAGAGCC	0.662000													28	90					0	0	0.183431	0	0
VWA9	81556	broad.mit.edu	37	15	65899626	65899626	+	Silent	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:65899626T>A	ENST00000395644.4	-	2	428	c.93A>T	c.(91-93)gcA>gcT	p.A31A	VWA9_ENST00000442903.3_Silent_p.A31A|VWA9_ENST00000569491.1_Intron|VWA9_ENST00000420799.2_Intron|VWA9_ENST00000313182.2_Silent_p.A31A|VWA9_ENST00000567744.1_Silent_p.A67A|VWA9_ENST00000431261.2_Intron					von Willebrand factor A domain containing 9																		AACCATGGGCTGCTAGGTGCT	0.468000													29	43					0	0	0.134883	0	0
DNAH11	8701	broad.mit.edu	37	7	21698649	21698649	+	Splice_Site	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:21698649G>C	ENST00000328843.6	+	30	5374	c.5343_splice	c.e30+1	p.Q1781_splice	DNAH11_ENST00000409508.3_Splice_Site_p.Q1776_splice			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1781	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATAAAAAACAGGTATTACATA	0.383000									Kartagener syndrome				44	81					0	0	0.312237	0	0
TNFRSF8	943	broad.mit.edu	37	1	12170100	12170100	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:12170100G>T	ENST00000263932.2	+	6	737	c.515G>T	c.(514-516)gGc>gTc	p.G172V	TNFRSF8_ENST00000417814.2_Missense_Mutation_p.G61V	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	172					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCCCAGTGGCACCATCCCC	0.627000													19	24					7.45023e-12	8.82346e-12	0.219247	1	0
SPATA31D1	389763	broad.mit.edu	37	9	84603914	84603914	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:84603914C>T	ENST00000344803.2	+	1	228	c.181C>T	c.(181-183)Caa>Taa	p.Q61*		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TAATGACATCCAAAAGGTAAG	0.418000													187	27					0	0	0.323286	0	0
NEB	4703	broad.mit.edu	37	2	152544162	152544162	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:152544162G>A	ENST00000397345.3	-	26	2703	c.2501C>T	c.(2500-2502)gCc>gTc	p.A834V	NEB_ENST00000172853.10_Missense_Mutation_p.A834V|NEB_ENST00000409198.1_Missense_Mutation_p.A834V|NEB_ENST00000604864.1_Missense_Mutation_p.A834V|NEB_ENST00000427231.2_Missense_Mutation_p.A834V|NEB_ENST00000603639.1_Missense_Mutation_p.A834V	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	834					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		CTTGGTGTTGGCTTTGGCTGC	0.517000													39	49					0	0	0.279185	0	0
ANK2	287	broad.mit.edu	37	4	114279001	114279001	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:114279001A>T	ENST00000357077.4	+	38	9280	c.9227A>T	c.(9226-9228)cAg>cTg	p.Q3076L	ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.Q3043L|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	3043					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGACAATCACAGGGTACCACC	0.463000													68	36					0	0	0.323286	0	0
ROR1	4919	broad.mit.edu	37	1	64624702	64624702	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:64624702C>T	ENST00000371079.1	+	8	1588	c.1213C>T	c.(1213-1215)Ctg>Ttg	p.L405L	ROR1_ENST00000545203.1_5'UTR|RP11-24J23.2_ENST00000424995.1_RNA	NM_005012.3	NP_005003.2	Q01973	ROR1_HUMAN	receptor tyrosine kinase-like orphan receptor 1	405					transmembrane receptor protein tyrosine kinase signaling pathway	cytoplasm|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			breast(7)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(10)|ovary(6)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	51						AATGGAAATCCTGTACATACT	0.403000													186	124					0	0	0.323286	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24895697	24895697	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:24895697T>A	ENST00000382071.2	+	4	878	c.793T>A	c.(793-795)Tct>Act	p.S265T	C1QTNF9_ENST00000332018.4_Missense_Mutation_p.S265T|C1QTNF9-AS1_ENST00000449656.1_RNA			P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	265	C1q.					collagen	hormone activity			endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		TGTTCAGGTGTCTTTGGTCAA	0.478000													46	74					0	0	0.323286	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130319699	130319699	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:130319699C>A	ENST00000299164.2	+	1	831	c.831C>A	c.(829-831)tcC>tcA	p.S277S		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	277	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		ATCGTGACTCCGGGCCCAAGG	0.602000											OREG0021518	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	39					3.52763e-06	3.78685e-06	0.160694	1	0
BMPR1B	658	broad.mit.edu	37	4	96025611	96025611	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:96025611C>A	ENST00000515059.1	+	4	319	c.36C>A	c.(34-36)ggC>ggA	p.G12G	BMPR1B_ENST00000440890.2_Silent_p.G42G|BMPR1B_ENST00000502683.1_Silent_p.G12G|BMPR1B_ENST00000394931.1_Silent_p.G12G|BMPR1B_ENST00000264568.4_Silent_p.G12G	NM_001203.2	NP_001194.1	O00238	BMR1B_HUMAN	bone morphogenetic protein receptor, type IB	12					BMP signaling pathway|cartilage condensation|eye development|limb morphogenesis|ovarian cumulus expansion|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	receptor complex	ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(8)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.51e-07)		TAAATGTGGGCACCAAGAAAG	0.468000													12	52					1.61879e-10	1.86788e-10	0.093190	1	0
BDP1	55814	broad.mit.edu	37	5	70785278	70785278	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:70785278A>G	ENST00000358731.4	+	10	1524	c.1261A>G	c.(1261-1263)Atg>Gtg	p.M421V	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	421	Required for phosphorylation by CSNK2A1.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AGATGAGTCTATGAGTTCTAG	0.373000													20	36					0	0	0.189662	0	0
OR9Q1	219956	broad.mit.edu	37	11	57946994	57946994	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:57946994T>C	ENST00000335397.3	+	3	394	c.78T>C	c.(76-78)ccT>ccC	p.P26P		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	26					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				GGGCACTCCCTCTCTTCCTCT	0.458000													120	258					0	0	0.323286	0	0
SHD	56961	broad.mit.edu	37	19	4283231	4283231	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:4283231C>A	ENST00000543264.2	+	3	2047	c.584C>A	c.(583-585)gCg>gAg	p.A195E	SHD_ENST00000599689.1_Missense_Mutation_p.A195E	NM_020209.3	NP_064594.3	Q96IW2	SHD_HUMAN	Src homology 2 domain containing transforming protein D	195										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|stomach(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0337)|STAD - Stomach adenocarcinoma(1328;0.18)		ATCTCCAGGGCGTTTGCAGGT	0.542000													29	0					2.61193e-14	3.22663e-14	0.144211	1	0
OR7A5	26659	broad.mit.edu	37	19	14938364	14938364	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:14938364T>C	ENST00000322301.3	-	2	777	c.690A>G	c.(688-690)tcA>tcG	p.S230S	OR7A5_ENST00000594432.1_Silent_p.S230S|OR7A5_ENST00000601611.1_Intron			Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A, member 5	230					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26						TCCCCTGAGCTGATGAGATTG	0.453000													62	147					0	0	0.323286	0	0
ADAM19	8728	broad.mit.edu	37	5	156917449	156917449	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:156917449C>A	ENST00000257527.4	-	19	2187	c.2109G>T	c.(2107-2109)gtG>gtT	p.V703V	ADAM19_ENST00000517905.1_Silent_p.V703V|ADAM19_ENST00000394020.1_Silent_p.V705V|ADAM19_ENST00000430702.2_Silent_p.V436V	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	703					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCCAGCTACCACAGGACCCA	0.502000													64	78					2.68927e-46	4.46338e-46	0.323286	1	0
USH2A	7399	broad.mit.edu	37	1	215940052	215940052	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:215940052A>G	ENST00000366943.2	-	56	11404	c.11018T>C	c.(11017-11019)cTa>cCa	p.L3673P	USH2A_ENST00000307340.3_Missense_Mutation_p.L3673P			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3673	Fibronectin type-III 21.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGTCTGACCTAGAAAAGGCTC	0.433000										HNSCC(13;0.011)			93	287					0	0	0.323286	0	0
UCK2	7371	broad.mit.edu	37	1	165865547	165865547	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:165865547G>T	ENST00000367879.4	+	4	780	c.477G>T	c.(475-477)gcG>gcT	p.A159A	RP11-525G13.2_ENST00000455257.1_RNA|UCK2_ENST00000372212.4_Intron	NM_012474.4	NP_036606.2	Q9BZX2	UCK2_HUMAN	uridine-cytidine kinase 2	159					pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|phosphotransferase activity, alcohol group as acceptor|uridine kinase activity			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10	all_hematologic(923;0.048)|Acute lymphoblastic leukemia(8;0.155)					ATACAGATGCGGACACCCGGC	0.592000													136	289					1.23427e-62	2.17065e-62	0.323286	1	0
ABCA5	23461	broad.mit.edu	37	17	67247941	67247941	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:67247941C>A	ENST00000392676.3	-	35	4546	c.4482G>T	c.(4480-4482)gaG>gaT	p.E1494D	ABCA5_ENST00000588877.1_Missense_Mutation_p.E1494D|ABCA5_ENST00000392677.2_Missense_Mutation_p.E1495D			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	1494	ABC transporter 2.				cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					CCTCTGCCTCCTCCATATAGT	0.448000													46	23					2.02627e-32	3.10508e-32	0.323286	1	0
BMPER	168667	broad.mit.edu	37	7	34014328	34014328	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:34014328G>T	ENST00000297161.2	+	7	882	c.508G>T	c.(508-510)Ggt>Tgt	p.G170C	BMPER_ENST00000426693.1_Missense_Mutation_p.G170C	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	170	VWFC 3.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						TGTGTTTGAGGGTGTGCAGTA	0.478000													77	125					1.92282e-43	3.15914e-43	0.323286	1	0
SLIT2	9353	broad.mit.edu	37	4	20255564	20255564	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:20255564C>A	ENST00000504154.1	+	1	378	c.126C>A	c.(124-126)caC>caA	p.H42Q	SLIT2_ENST00000273739.5_Missense_Mutation_p.H42Q|SLIT2_ENST00000503823.1_Missense_Mutation_p.H42Q|SLIT2_ENST00000503837.1_Missense_Mutation_p.H42Q	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	42	LRRNT.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TGGACTGTCACGGGCTGGCGC	0.662000													23	22					5.35356e-11	6.23307e-11	0.264190	1	0
GRM1	2911	broad.mit.edu	37	6	146480564	146480564	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:146480564A>C	ENST00000392299.2	+	3	1251	c.781A>C	c.(781-783)Atc>Ctc	p.I261L	GRM1_ENST00000361719.2_Missense_Mutation_p.I261L|GRM1_ENST00000355289.4_Missense_Mutation_p.I261L|GRM1_ENST00000507907.1_Missense_Mutation_p.I261L|GRM1_ENST00000282753.1_Missense_Mutation_p.I261L|GRM1_ENST00000492807.2_Missense_Mutation_p.I261L			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	261					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTCTGACAAAATCTACAGCAA	0.532000													64	161					0	0	0.323286	0	0
RPL10L	140801	broad.mit.edu	37	14	47120603	47120603	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:47120603T>C	ENST00000298283.3	-	1	425	c.337A>G	c.(337-339)Aca>Gca	p.T113A		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	113					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						CGCATACCTGTCTGGAGCCTG	0.552000													57	53					0	0	0.323286	0	0
ZNF845	91664	broad.mit.edu	37	19	53856730	53856730	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:53856730G>A	ENST00000458035.1	+	4	2919	c.2802G>A	c.(2800-2802)aaG>aaA	p.K934K	ZNF845_ENST00000595091.1_Silent_p.K934K	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	934					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K934K(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TAATTCATAAGACAATTCATA	0.368000													5	62					0	0	0.248553	0	0
ALPP	250	broad.mit.edu	37	2	233244941	233244941	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:233244941C>A	ENST00000392027.2	+	6	972	c.703C>A	c.(703-705)Cca>Aca	p.P235T	AC068134.8_ENST00000441266.1_RNA|AC068134.8_ENST00000439072.1_RNA	NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	235						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		CATGGGAACCCCAGACCCTGA	0.627000													27	206					2.09667e-21	2.85298e-21	0.193644	1	0
C17orf74	201243	broad.mit.edu	37	17	7330130	7330130	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:7330130G>C	ENST00000333870.3	+	3	894	c.820G>C	c.(820-822)Gag>Cag	p.E274Q	RP11-104H15.7_ENST00000575310.1_RNA|C17orf74_ENST00000574034.1_3'UTR	NM_175734.4	NP_783861.3	Q0P670	CQ074_HUMAN	chromosome 17 open reading frame 74	274						integral to membrane				cervix(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	22		Prostate(122;0.157)				TGTGGAGGCTGAGCAGTGGGC	0.667000													18	10					0	0	0.189662	0	0
STK32B	55351	broad.mit.edu	37	4	5418572	5418572	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:5418572G>T	ENST00000282908.5	+	6	895	c.472_splice	c.e6-1	p.G158_splice	STK32B_ENST00000512636.1_Intron|STK32B_ENST00000510398.1_Splice_Site_p.G111_splice	NM_018401.1	NP_060871.1	Q9NY57	ST32B_HUMAN	serine/threonine kinase 32B	158	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(16)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	39						GTATTTGCAGGACATGTTCAC	0.483000													11	18					0.00316338	0.00325265	0.132662	1	0
DISC1	27185	broad.mit.edu	37	1	231829710	231829710	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:231829710G>T	ENST00000439617.2	+	2	259	c.206G>T	c.(205-207)gGa>gTa	p.G69V	DISC1_ENST00000602873.1_Intron|DISC1_ENST00000535983.1_Missense_Mutation_p.G69V|DISC1_ENST00000366633.3_Missense_Mutation_p.G69V|TRAX_ENST00000602962.1_3'UTR|DISC1_ENST00000366636.4_Missense_Mutation_p.G69V|DISC1_ENST00000539444.1_Missense_Mutation_p.G69V|DISC1_ENST00000366637.3_5'UTR|DISC1_ENST00000317586.4_Missense_Mutation_p.G69V|DISC1_ENST00000602281.1_Missense_Mutation_p.G69V|DISC1_ENST00000537876.1_Missense_Mutation_p.G69V	NM_001164537.1|NM_001164540.1|NM_018662.2	NP_001158009.1|NP_001158012.1|NP_061132.2	Q9NRI5	DISC1_HUMAN	disrupted in schizophrenia 1	69	Interaction with MAP1A.				microtubule cytoskeleton organization|neuron migration|positive regulation of neuroblast proliferation|positive regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	centrosome|microtubule	protein binding			breast(1)|cervix(1)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15		all_cancers(173;0.0208)|Prostate(94;0.0975)				CGGTTCCCAGGAGGGGTGTCT	0.652000													10	48					1.49906e-05	1.59102e-05	0.119110	1	0
DUSP12	11266	broad.mit.edu	37	1	161726734	161726734	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:161726734A>G	ENST00000367943.4	+	6	1052	c.1020A>G	c.(1018-1020)atA>atG	p.I340M	DUSP12_ENST00000484291.1_3'UTR	NM_007240.1	NP_009171.1	Q9UNI6	DUS12_HUMAN	dual specificity phosphatase 12	340					positive regulation of glucokinase activity	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|lung(1)	5	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CAGGAAAAATATGAACATGAT	0.358000													28	13					0	0	0.324025	0	0
SPEG	10290	broad.mit.edu	37	2	220348024	220348024	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:220348024C>G	ENST00000312358.7	+	30	5971	c.5839C>G	c.(5839-5841)Cgg>Ggg	p.R1947G	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1947					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTCTGGCTCCCGGGTGTCCCT	0.662000													10	10					0	0	0.080935	0	0
FILIP1	27145	broad.mit.edu	37	6	76124487	76124487	+	Nonsense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:76124487T>A	ENST00000393004.2	-	2	423	c.202A>T	c.(202-204)Aaa>Taa	p.K68*	FILIP1_ENST00000237172.7_Nonsense_Mutation_p.K68*			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	68										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TTCTTAGTTTTTCGTTCACAT	0.403000													176	464					0	0	0.323286	0	0
SPTA1	6708	broad.mit.edu	37	1	158632543	158632543	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:158632543C>A	ENST00000368148.3	-	17	2593	c.2413G>T	c.(2413-2415)Gag>Tag	p.E805*	SPTA1_ENST00000368147.3_Nonsense_Mutation_p.E805*	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	805					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CAGGCCTCCTCATCCTCTGTG	0.517000													61	52					9.04393e-38	1.43931e-37	0.323286	1	0
STAB1	23166	broad.mit.edu	37	3	52558144	52558144	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:52558144C>A	ENST00000321725.6	+	68	7647	c.7571C>A	c.(7570-7572)tCa>tAa	p.S2524*		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	2524					cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GACGACTTCTCACCGTGGCAA	0.597000													8	17					0.0381472	0.0387605	0.278610	1	0
DNHD1	144132	broad.mit.edu	37	11	6592889	6592889	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:6592889G>T	ENST00000254579.6	+	43	14499	c.13935G>T	c.(13933-13935)acG>acT	p.T4645T	DNHD1_ENST00000527990.2_Silent_p.T4645T	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	4645					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CAAATCCCACGGTTCCAGAGA	0.612000													24	10					6.38683e-12	7.57565e-12	0.134883	1	0
GPR6	2830	broad.mit.edu	37	6	110300597	110300597	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:110300597G>T	ENST00000414000.2	+	3	566	c.327G>T	c.(325-327)gtG>gtT	p.V109V	GPR6_ENST00000275169.3_Silent_p.V94V			P46095	GPR6_HUMAN	G protein-coupled receptor 6	94						integral to plasma membrane				breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;1.64e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;2.83e-05)|all_lung(197;0.00016)|Lung NSC(302;0.000318)|Colorectal(196;0.0488)		BRCA - Breast invasive adenocarcinoma(108;8.01e-05)|Epithelial(106;8.76e-05)|all cancers(137;0.000197)|OV - Ovarian serous cystadenocarcinoma(136;0.0307)		CGCTGGTGGTGGCGCTCATCG	0.682000													54	123					2.47907e-22	3.426e-22	0.323286	1	0
FAT3	120114	broad.mit.edu	37	11	92088162	92088162	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:92088162G>C	ENST00000298047.6	+	1	2901	c.2884G>C	c.(2884-2886)Gat>Cat	p.D962H	FAT3_ENST00000525166.1_Missense_Mutation_p.D812H|FAT3_ENST00000541502.1_Missense_Mutation_p.D962H|FAT3_ENST00000409404.2_Missense_Mutation_p.D962H			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	962	Cadherin 9.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGAGACCCATGATCCAGATCT	0.468000										TCGA Ovarian(4;0.039)			48	95					0	0	0.323286	0	0
ZNF521	25925	broad.mit.edu	37	18	22805578	22805578	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:22805578C>T	ENST00000361524.3	-	4	2452	c.2304G>A	c.(2302-2304)caG>caA	p.Q768Q	ZNF521_ENST00000538137.2_Silent_p.Q768Q|ZNF521_ENST00000584787.1_Silent_p.Q548Q	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	768					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					TCACATGGAGCTGCAAGTCAG	0.493000			T	PAX5	ALL								52	179					0	0	0.323286	0	0
NPHP4	261734	broad.mit.edu	37	1	5934991	5934991	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:5934991T>G	ENST00000378156.4	-	21	3252	c.2987A>C	c.(2986-2988)aAg>aCg	p.K996T	NPHP4_ENST00000478423.2_5'UTR	NM_015102.3	NP_055917.1	O75161	NPHP4_HUMAN	nephronophthisis 4	996					actin cytoskeleton organization|cell-cell adhesion|signal transduction|visual behavior	cell-cell junction|centrosome|cilium|microtubule basal body	protein binding|structural molecule activity			NS(1)|breast(2)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(4)	47	Ovarian(185;0.0634)	all_cancers(23;7.53e-41)|all_epithelial(116;3.96e-23)|all_lung(118;5.12e-09)|all_hematologic(16;5.45e-07)|Lung NSC(185;5.49e-07)|all_neural(13;3.21e-06)|Acute lymphoblastic leukemia(12;3.44e-05)|Breast(487;0.000601)|Renal(390;0.0007)|Colorectal(325;0.00113)|Hepatocellular(190;0.00213)|Glioma(11;0.00223)|Myeloproliferative disorder(586;0.0256)|Ovarian(437;0.04)|Lung SC(97;0.128)|Medulloblastoma(700;0.213)		Epithelial(90;1.69e-36)|GBM - Glioblastoma multiforme(13;5.07e-29)|OV - Ovarian serous cystadenocarcinoma(86;1.05e-19)|Colorectal(212;4.54e-07)|COAD - Colon adenocarcinoma(227;3.14e-05)|Kidney(185;0.00012)|BRCA - Breast invasive adenocarcinoma(365;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00179)|STAD - Stomach adenocarcinoma(132;0.00472)|READ - Rectum adenocarcinoma(331;0.0649)		GTGGGGGTTCTTAAGCACAAA	0.622000													47	92					0	0	0.323286	0	0
SLC5A11	115584	broad.mit.edu	37	16	24922713	24922713	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:24922713G>C	ENST00000347898.3	+	16	2509	c.1887G>C	c.(1885-1887)gaG>gaC	p.E629D	SLC5A11_ENST00000567758.1_Missense_Mutation_p.E594D|SLC5A11_ENST00000568579.1_Missense_Mutation_p.E559D|SLC5A11_ENST00000545376.1_Missense_Mutation_p.E559D|SLC5A11_ENST00000539472.1_Missense_Mutation_p.E565D|SLC5A11_ENST00000565769.1_Missense_Mutation_p.E565D|SLC5A11_ENST00000449109.2_Missense_Mutation_p.E473D|SLC5A11_ENST00000424767.2_Missense_Mutation_p.E594D|SLC5A11_ENST00000569071.1_Missense_Mutation_p.E473D	NM_052944.3	NP_443176.2	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/inositol cotransporter), member 11	629					apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(30)|ovary(2)|prostate(2)|urinary_tract(1)	49				GBM - Glioblastoma multiforme(48;0.0365)		GAATACAGGAGAAGGGCAAGG	0.527000													80	129					0	0	0.323286	0	0
LRRC16B	90668	broad.mit.edu	37	14	24528179	24528179	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:24528179T>G	ENST00000342740.5	+	19	1709	c.1555T>G	c.(1555-1557)Ttc>Gtc	p.F519V	LRRC16B_ENST00000334420.7_5'UTR	NM_138360.3	NP_612369.3	Q8ND23	LR16B_HUMAN	leucine rich repeat containing 16B	519										breast(3)|central_nervous_system(2)|cervix(3)|endometrium(7)|kidney(1)|large_intestine(9)|liver(1)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	52				GBM - Glioblastoma multiforme(265;0.019)		GGGCAAGAACTTCAATGTCAA	0.557000											OREG0022615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	56					0	0	0.125774	0	0
LOC101243545	101243545	broad.mit.edu	37	3	161147042	161147042	+	RNA	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:161147042T>G	ENST00000473595.1	+	0	1231				RP11-3P17.5_ENST00000602890.1_lincRNA	NR_102265.1																						GTCATAGAGCTTCTTCACAGC	0.448000													18	266					0	0	0.189662	0	0
SOX30	11063	broad.mit.edu	37	5	157073743	157073743	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:157073743T>A	ENST00000265007.6	-	3	1630	c.1289A>T	c.(1288-1290)aAt>aTt	p.N430I	SOX30_ENST00000519442.1_Missense_Mutation_p.N125I|SOX30_ENST00000311371.5_Missense_Mutation_p.N430I	NM_178424.1	NP_848511.1	O94993	SOX30_HUMAN	SRY (sex determining region Y)-box 30	430					regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|response to corticosteroid stimulus|transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	23	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.138)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAGATGATATTCTGTGTGGT	0.428000													11	95					0	0	0.069234	0	0
DNAH17	8632	broad.mit.edu	37	17	76510894	76510894	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:76510894G>A	ENST00000389840.5	-	26	4187	c.4063C>T	c.(4063-4065)Cgg>Tgg	p.R1355W	DNAH17_ENST00000585328.1_Missense_Mutation_p.R1356W					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGGCGTTCCCGAATGGCAGGG	0.642000													4	37					0	0	0.184627	0	0
CNTN1	1272	broad.mit.edu	37	12	41410621	41410621	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:41410621G>A	ENST00000551295.2	+	19	2439	c.2322G>A	c.(2320-2322)atG>atA	p.M774I	CNTN1_ENST00000347616.1_Missense_Mutation_p.M774I|CNTN1_ENST00000348761.2_Missense_Mutation_p.M763I|CNTN1_ENST00000550305.1_3'UTR	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	774	Fibronectin type-III 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				ATGAAACCATGAGCCCTTCCA	0.408000													61	179					0	0	0.323286	0	0
HDX	139324	broad.mit.edu	37	X	83599427	83599427	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:83599427C>A	ENST00000297977.5	-	6	1602	c.1491G>T	c.(1489-1491)atG>atT	p.M497I	HDX_ENST00000373177.2_Missense_Mutation_p.M497I|HDX_ENST00000506585.2_Missense_Mutation_p.M439I	NM_001177479.1|NM_144657.4	NP_001170950.1|NP_653258.2	Q7Z353	HDX_HUMAN	highly divergent homeobox	497						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(12)|liver(1)|lung(19)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						CTTCAATCCCCATTAAACGAT	0.438000													43	8					8.04919e-23	1.11786e-22	0.323286	1	0
ARFGEF1	10565	broad.mit.edu	37	8	68138279	68138279	+	Silent	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:68138279T>C	ENST00000262215.3	-	28	4445	c.4056A>G	c.(4054-4056)aaA>aaG	p.K1352K	ARFGEF1_ENST00000518230.1_Silent_p.K190K|ARFGEF1_ENST00000520381.1_Silent_p.K806K	NM_006421.4	NP_006412.2	Q9Y6D6	BIG1_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)	1352					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			breast(1)|endometrium(14)|kidney(4)|large_intestine(17)|lung(20)|ovary(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			CAGACACATATTTTGCACAAT	0.383000													8	52					0	0	0.058154	0	0
GPRASP2	114928	broad.mit.edu	37	X	101972045	101972045	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:101972045G>T	ENST00000543253.1	+	5	3167	c.2248G>T	c.(2248-2250)Gct>Tct	p.A750S	GPRASP2_ENST00000332262.5_Missense_Mutation_p.A750S|GPRASP2_ENST00000535209.1_Missense_Mutation_p.A750S	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						TGAAAATCCTGCTGTGGCAAA	0.348000													81	9					3.1371e-51	5.32362e-51	0.323286	1	0
DPY19L3	147991	broad.mit.edu	37	19	32945898	32945898	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:32945898T>G	ENST00000342179.5	+	10	1256	c.1041T>G	c.(1039-1041)caT>caG	p.H347Q	DPY19L3_ENST00000586987.1_Missense_Mutation_p.H347Q|DPY19L3_ENST00000392250.2_Missense_Mutation_p.H347Q	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	347						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					TTTTGTTACATTTATTTATGG	0.234000													50	159					0	0	0.323286	0	0
FAM19A1	407738	broad.mit.edu	37	3	68055822	68055822	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:68055822G>T	ENST00000478136.1	+	2	543	c.53G>T	c.(52-54)tGt>tTt	p.C18F	FAM19A1_ENST00000496687.1_Missense_Mutation_p.C18F	NM_213609.3	NP_998774.2	Q7Z5A9	F19A1_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A1	18						endoplasmic reticulum|extracellular region				central_nervous_system(1)|endometrium(1)|kidney(1)|lung(3)|ovary(1)	7		Lung NSC(201;0.0117)		BRCA - Breast invasive adenocarcinoma(55;7.7e-05)|Epithelial(33;0.000937)|KIRC - Kidney renal clear cell carcinoma(39;0.0579)|Kidney(39;0.0743)		ATAAGTGCTTGTGCAATGCTA	0.527000													383	265					1.71707e-188	3.19384e-188	0.323286	1	0
B9D1	27077	broad.mit.edu	37	17	19250477	19250477	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:19250477G>A	ENST00000268841.6	-	6	536	c.437C>T	c.(436-438)gCt>gTt	p.A146V	B9D1_ENST00000395616.3_Intron|B9D1_ENST00000461069.2_Intron|B9D1_ENST00000261499.4_Intron|B9D1_ENST00000477478.2_Intron|B9D1_ENST00000395615.1_Intron|B9D1_ENST00000575403.1_Intron			Q9UPM9	B9D1_HUMAN	B9 protein domain 1	0					cilium assembly	centrosome|microtubule basal body	protein binding			large_intestine(3)|urinary_tract(1)	4	all_cancers(12;2.04e-05)|all_epithelial(12;0.000806)|Hepatocellular(7;0.00345)|Breast(13;0.143)					GGGTGGAGCAGCTTGCAGATC	0.567000													3	35					0	0	0.115264	0	0
ATP13A1	57130	broad.mit.edu	37	19	19770477	19770477	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19770477G>A	ENST00000357324.6	-	3	636	c.610C>T	c.(610-612)Cag>Tag	p.Q204*	ATP13A1_ENST00000291503.5_Nonsense_Mutation_p.Q86*	NM_020410.2	NP_065143.2	Q9HD20	AT131_HUMAN	ATPase type 13A1	204					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						CTGTTGCTCTGATAGTATGAG	0.498000													9	81					0	0	0.069234	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133253	91133253	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:91133253G>A	ENST00000373094.1	+	2	2859	c.2014G>A	c.(2014-2016)Gtt>Att	p.V672I	PCDH11X_ENST00000361724.1_Missense_Mutation_p.V672I|PCDH11X_ENST00000373097.1_Missense_Mutation_p.V672I|PCDH11X_ENST00000373088.1_Missense_Mutation_p.V672I|PCDH11X_ENST00000361655.2_Missense_Mutation_p.V672I|PCDH11X_ENST00000395337.2_Missense_Mutation_p.V672I|PCDH11X_ENST00000298274.8_Missense_Mutation_p.V672I|PCDH11X_ENST00000504220.1_Missense_Mutation_p.V672I|PCDH11X_ENST00000406881.1_Missense_Mutation_p.V672I	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	672	Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CAACAAACCAGTTTTCATTGT	0.413000													52	65					0	0	0.323286	0	0
MAB21L1	4081	broad.mit.edu	37	13	36049420	36049420	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:36049420G>T	ENST00000379919.4	-	1	1412	c.856C>A	c.(856-858)Ccc>Acc	p.P286T	NBEA_ENST00000540320.1_Intron|NBEA_ENST00000400445.3_Intron|NBEA_ENST00000379939.2_Intron|NBEA_ENST00000310336.4_Intron	NM_005584.4	NP_005575.1	Q13394	MB211_HUMAN	mab-21-like 1 (C. elegans)	286					anatomical structure morphogenesis	nucleus				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	20		Breast(139;0.014)|Lung SC(185;0.051)|Prostate(109;0.202)		all cancers(112;9.63e-08)|Epithelial(112;1.37e-06)|BRCA - Breast invasive adenocarcinoma(63;0.000659)|OV - Ovarian serous cystadenocarcinoma(117;0.00372)|GBM - Glioblastoma multiforme(144;0.115)		GACTCTCGGGGATGCTTTTCA	0.542000													31	53					2.47316e-13	2.99897e-13	0.183431	1	0
TTN	7273	broad.mit.edu	37	2	179500193	179500193	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179500193C>G	ENST00000589042.1	-	227	42082	c.41858G>C	c.(41857-41859)aGa>aCa	p.R13953T	TTN_ENST00000342175.6_Missense_Mutation_p.R5080T|TTN_ENST00000359218.5_Missense_Mutation_p.R5013T|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R12312T|TTN_ENST00000460472.2_Missense_Mutation_p.R4888T|TTN_ENST00000342992.6_Missense_Mutation_p.R11385T|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12312	Ig-like 95.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCAGGGTATCTTTTTCCTTC	0.343000													4	31					0	0	0.150653	0	0
OR10V1	390201	broad.mit.edu	37	11	59481231	59481231	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:59481231C>A	ENST00000307552.2	-	1	106	c.88G>T	c.(88-90)Gtc>Ttc	p.V30F	STX3_ENST00000300150.7_5'UTR	NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						ATCAGGAAGACCACAAAAATC	0.428000													24	85					1.66031e-10	1.91436e-10	0.294199	1	0
EEFSEC	60678	broad.mit.edu	37	3	128060514	128060514	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:128060514C>G	ENST00000254730.6	+	5	1279	c.1225C>G	c.(1225-1227)Cag>Gag	p.Q409E	EEFSEC_ENST00000483569.1_3'UTR|EEFSEC_ENST00000483457.1_Missense_Mutation_p.Q354E	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	409						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						TTGTCCTCGGCAGCAGTGGGC	0.602000													11	29					0	0	0.080935	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045333	142045333	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142045333C>A	ENST00000390392.3	+	0	82																											GGACCCCAGTCAGAGGCCCCA	0.602000													48	123					3.48956e-15	4.36477e-15	0.323286	1	0
TCF19	6941	broad.mit.edu	37	6	31130328	31130328	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:31130328C>G	ENST00000376257.3	+	4	1626	c.872C>G	c.(871-873)cCc>cGc	p.P291R	TCF19_ENST00000496421.1_3'UTR|TCF19_ENST00000376255.4_Missense_Mutation_p.P291R	NM_007109.2	NP_009040.2	Q9Y242	TCF19_HUMAN	transcription factor 19	291	Pro-rich.				cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	9						GGCGGGGAGCCCTGTGCAGCT	0.617000													15	49					0	0	0.146539	0	0
EHMT1	79813	broad.mit.edu	37	9	140637941	140637941	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:140637941G>T	ENST00000460843.1	+	5	969	c.942G>T	c.(940-942)gaG>gaT	p.E314D	EHMT1_ENST00000462484.1_Missense_Mutation_p.E314D|EHMT1_ENST00000371394.2_3'UTR|EHMT1_ENST00000334856.6_Missense_Mutation_p.E283D	NM_024757.4	NP_079033.4	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	314					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	41	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CGGTGATTGAGATGTTTAAGA	0.443000													47	40					5.13769e-22	7.05919e-22	0.323286	1	0
TTN	7273	broad.mit.edu	37	2	179590626	179590626	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:179590626T>C	ENST00000589042.1	-	70	20647	c.20423A>G	c.(20422-20424)aAg>aGg	p.K6808R	TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron|RP11-171I2.1_ENST00000590024.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.K6491R|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.K5564R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6491	Ig-like 49.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGATGCAATCTTGTATTTCTT	0.433000													27	63					0	0	0.125774	0	0
WDTC1	23038	broad.mit.edu	37	1	27627882	27627882	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:27627882G>T	ENST00000319394.3	+	13	1933	c.1398G>T	c.(1396-1398)caG>caT	p.Q466H	WDTC1_ENST00000361771.3_Missense_Mutation_p.Q465H	NM_001276252.1|NM_015023.3	NP_001263181.1|NP_055838.2	Q8N5D0	WDTC1_HUMAN	WD and tetratricopeptide repeats 1	466							protein binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	21		all_cancers(24;3.12e-19)|all_epithelial(13;4.18e-18)|Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.00257)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0443)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-27)|Colorectal(126;8.83e-09)|COAD - Colon adenocarcinoma(152;1.02e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000544)|KIRC - Kidney renal clear cell carcinoma(1967;0.00201)|STAD - Stomach adenocarcinoma(196;0.00321)|READ - Rectum adenocarcinoma(331;0.0476)		TTCCGGAGCAGGCCCACAGCA	0.572000											OREG0013280	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	83					5.91797e-21	8.02801e-21	0.163468	1	0
HR	55806	broad.mit.edu	37	8	21977319	21977319	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:21977319C>T	ENST00000381418.4	-	14	4411	c.2931G>A	c.(2929-2931)ccG>ccA	p.P977P	HR_ENST00000312841.8_Silent_p.P977P	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	977	JmjC.						DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		GGGCAAGGCCCGGTGGGAGGT	0.632000													12	1					0	0	0.175082	0	0
SP140	11262	broad.mit.edu	37	2	231120199	231120199	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:231120199G>T	ENST00000392045.3	+	12	1306	c.1192G>T	c.(1192-1194)Gga>Tga	p.G398*	SP140_ENST00000417495.3_Nonsense_Mutation_p.G284*|SP140_ENST00000420434.3_Intron|SP140_ENST00000343805.6_Nonsense_Mutation_p.G338*|SP140_ENST00000350136.5_Nonsense_Mutation_p.G267*|SP140_ENST00000486687.2_Nonsense_Mutation_p.G322*	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	398					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AATGTGTGATGGAGAAGAGCG	0.527000													42	293					2.76378e-25	3.93537e-25	0.323286	1	0
OR4A15	81328	broad.mit.edu	37	11	55136147	55136147	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55136147A>T	ENST00000314706.3	+	1	788	c.788A>T	c.(787-789)aAa>aTa	p.K263I		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						GGGAAACGAAAAGCTTTCTAC	0.433000													20	218					0	0	0.219247	0	0
SLC6A6	6533	broad.mit.edu	37	3	14526392	14526392	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:14526392G>T	ENST00000454876.2	+	15	2069	c.1740G>T	c.(1738-1740)ctG>ctT	p.L580L	SLC6A6_ENST00000360861.3_Silent_p.L580L			P31641	SC6A6_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 6	580					cellular amino acid metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity|taurine:sodium symporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)	28						AGTACCTGCTGACCCCAAGGG	0.622000													45	39					1.81118e-26	2.61259e-26	0.323286	1	0
DEF8	54849	broad.mit.edu	37	16	90028216	90028216	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:90028216G>T	ENST00000563594.1	+	8	1748	c.751G>T	c.(751-753)Gac>Tac	p.D251Y	DEF8_ENST00000563795.1_Missense_Mutation_p.D251Y|DEF8_ENST00000563848.1_3'UTR|DEF8_ENST00000569453.1_Missense_Mutation_p.D251Y|DEF8_ENST00000268676.7_Missense_Mutation_p.D312Y|DEF8_ENST00000570182.1_Missense_Mutation_p.D241Y|DEF8_ENST00000567874.1_Missense_Mutation_p.D191Y	NM_001242818.1|NM_001242819.1	NP_001229747.1|NP_001229748.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	312					intracellular signal transduction		zinc ion binding	p.D312N(1)		central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		CCACTGGAACGACCTGGCTGT	0.642000													4	15					5.18039e-06	5.55721e-06	0.278610	1	0
HAS1	3036	broad.mit.edu	37	19	52222630	52222630	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:52222630C>T	ENST00000540069.2	-	2	588	c.528G>A	c.(526-528)gcG>gcA	p.A176A	HAS1_ENST00000594621.1_Silent_p.A31A|HAS1_ENST00000601714.1_Silent_p.A184A|HAS1_ENST00000222115.1_Silent_p.A177A			Q92839	HAS1_HUMAN	hyaluronan synthase 1	177					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		cggcgcccaccgcgcccgccg	0.716000													4	7					0	0	0.307466	0	0
SRRT	51593	broad.mit.edu	37	7	100484696	100484696	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100484696G>C	ENST00000388793.4	+	15	2067	c.1847G>C	c.(1846-1848)cGc>cCc	p.R616P	SRRT_ENST00000347433.4_Missense_Mutation_p.R617P|SRRT_ENST00000432932.1_Missense_Mutation_p.R616P|SRRT_ENST00000457580.2_Missense_Mutation_p.R617P	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	617					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						CTTTACCTGCGCATCGTGCAT	0.602000													120	251					0	0	0.323286	0	0
ANGPTL5	253935	broad.mit.edu	37	11	101762169	101762169	+	Missense_Mutation	SNP	G	G	T	rs139900371	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:101762169G>T	ENST00000334289.3	-	9	1603	c.1008C>A	c.(1006-1008)aaC>aaA	p.N336K		NM_178127.4	NP_835228.2	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5	336	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding	p.N336K(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|ovary(2)|skin(3)	29		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		GACCACACTCGTTAAACCACC	0.478000													114	260					5.65518e-33	8.73086e-33	0.323286	1	0
HPR	3250	broad.mit.edu	37	16	72110641	72110641	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:72110641C>A	ENST00000540303.2	+	5	740	c.708C>A	c.(706-708)gaC>gaA	p.D236E	HPR_ENST00000561690.1_Intron|HPR_ENST00000356967.5_Missense_Mutation_p.D236E|HPR_ENST00000228226.8_Missense_Mutation_p.D273E	NM_020995.3	NP_066275.3	P00739	HPTR_HUMAN	haptoglobin-related protein	236	Peptidase S1.				proteolysis	spherical high-density lipoprotein particle	hemoglobin binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|stomach(1)|urinary_tract(2)	20		Ovarian(137;0.125)				AACTTACTGACCATCTGAAGT	0.493000													66	145					1.64915e-30	2.47693e-30	0.323286	1	0
PFKM	5213	broad.mit.edu	37	12	48538854	48538854	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:48538854A>C	ENST00000340802.6	+	23	2470	c.2246A>C	c.(2245-2247)aAg>aCg	p.K749T	PFKM_ENST00000359794.5_Missense_Mutation_p.K678T|PFKM_ENST00000551804.1_Missense_Mutation_p.K647T|PFKM_ENST00000312352.7_Missense_Mutation_p.K678T|PFKM_ENST00000547587.1_Missense_Mutation_p.K678T|PFKM_ENST00000395233.2_Missense_Mutation_p.K647T	NM_001166686.1	NP_001160158.1	P08237	K6PF_HUMAN	phosphofructokinase, muscle	678					fructose 6-phosphate metabolic process|glycolysis|muscle cell homeostasis	6-phosphofructokinase complex|apical plasma membrane	6-phosphofructokinase activity|ATP binding|identical protein binding|kinase binding|metal ion binding|protein C-terminus binding			NS(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						TTTGCCACTAAGATGGGCGCC	0.473000													35	74					0	0	0.257332	0	0
PCDHB3	56132	broad.mit.edu	37	5	140481763	140481763	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140481763C>A	ENST00000231130.2	+	1	1530	c.1530C>A	c.(1528-1530)aaC>aaA	p.N510K	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		510	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACGCGGACAACGGCCACCTGT	0.667000													45	49					3.94896e-32	6.0246e-32	0.323286	1	0
IGF1R	3480	broad.mit.edu	37	15	99459972	99459972	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:99459972G>T	ENST00000268035.6	+	10	2679	c.2068G>T	c.(2068-2070)Gag>Tag	p.E690*	IGF1R_ENST00000558762.1_Nonsense_Mutation_p.E690*	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	690					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CCCCAAGACTGAGGTGTGTGG	0.532000													27	58					5.45727e-16	6.90971e-16	0.134883	1	0
HEATR3	55027	broad.mit.edu	37	16	50128684	50128684	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:50128684G>C	ENST00000299192.7	+	12	1770	c.1579G>C	c.(1579-1581)Gcc>Ccc	p.A527P	HEATR3_ENST00000564942.1_3'UTR|HEATR3_ENST00000285767.4_Missense_Mutation_p.A441P	NM_182922.2	NP_891552.1	Q7Z4Q2	HEAT3_HUMAN	HEAT repeat containing 3	527							binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	28						GCAAACAATGGCCTCCAAGAA	0.308000													72	17					0	0	0.323286	0	0
ANKRD26	22852	broad.mit.edu	37	10	27301833	27301833	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:27301833C>A	ENST00000376087.4	-	32	5096	c.4931G>T	c.(4930-4932)aGc>aTc	p.S1644I	ANKRD26_ENST00000376070.3_Missense_Mutation_p.S1201I|ANKRD26_ENST00000436985.2_Missense_Mutation_p.S1660I	NM_001256053.1|NM_014915.2	NP_001242982.1|NP_055730.2	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	1643						centrosome				breast(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|urinary_tract(2)	70						GTTCTCCATGCTATTATTTGA	0.328000													51	210					4.96213e-28	7.26606e-28	0.323286	1	0
TIMD4	91937	broad.mit.edu	37	5	156378688	156378688	+	Missense_Mutation	SNP	C	C	A	rs55920848	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:156378688C>A	ENST00000274532.2	-	3	570	c.514G>T	c.(514-516)Gtg>Ttg	p.V172L	TIMD4_ENST00000407087.3_Missense_Mutation_p.V172L	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	172	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGTGTGGTCACGACTGTTGTT	0.537000													148	225					1.70475e-107	3.12404e-107	0.323286	1	0
ADCY2	108	broad.mit.edu	37	5	7727311	7727311	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:7727311A>T	ENST00000338316.4	+	14	1897	c.1808A>T	c.(1807-1809)tAt>tTt	p.Y603F	RP11-711G10.1_ENST00000514105.2_RNA|ADCY2_ENST00000537121.1_Missense_Mutation_p.Y423F	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	603					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TTCAAGTATTATGTGACTTGT	0.507000													86	85					0	0	0.323286	0	0
KLHDC1	122773	broad.mit.edu	37	14	50177066	50177066	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:50177066G>T	ENST00000359332.2	+	4	461	c.371G>T	c.(370-372)cGt>cTt	p.R124L		NM_172193.2	NP_751943.1	Q8N7A1	KLDC1_HUMAN	kelch domain containing 1	124						cytoplasm				kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	12	all_epithelial(31;0.00244)|Breast(41;0.00964)					CCTACACCACGTGATAAACTT	0.363000													115	129					1.8369e-69	3.26385e-69	0.323286	1	0
CYP2A6	1548	broad.mit.edu	37	19	41356192	41356192	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:41356192A>G	ENST00000301141.5	-	1	160	c.140T>C	c.(139-141)cTg>cCg	p.L47P	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	47					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	GTTCAGCTGCAGGTAGTTTCC	0.577000													314	17					0	0	0.323286	0	0
UTRN	7402	broad.mit.edu	37	6	144806607	144806607	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:144806607C>T	ENST00000367545.3	+	27	3774	c.3774C>T	c.(3772-3774)agC>agT	p.S1258S		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	1258					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		GGATGAAGAGCACAGAGGTCC	0.488000													59	126					0	0	0.323286	0	0
CELSR3	1951	broad.mit.edu	37	3	48697556	48697556	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:48697556G>T	ENST00000544264.1	-	1	2792	c.2512C>A	c.(2512-2514)Ctt>Att	p.L838I	CELSR3_ENST00000164024.4_Missense_Mutation_p.L838I			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	838	Cadherin 5.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGATCATGAAGGGCACGGTCA	0.532000													64	161					2.19297e-23	3.06758e-23	0.323286	1	0
STXBP5L	9515	broad.mit.edu	37	3	120973802	120973802	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:120973802G>T	ENST00000273666.6	+	16	1773	c.1502G>T	c.(1501-1503)gGa>gTa	p.G501V	STXBP5L_ENST00000497029.1_Missense_Mutation_p.G501V|STXBP5L_ENST00000472879.1_Missense_Mutation_p.G501V|STXBP5L_ENST00000492541.1_Missense_Mutation_p.G501V|STXBP5L_ENST00000471454.1_Missense_Mutation_p.G501V	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	501					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		CAGAAGGTAGGAGAAGGAAAA	0.368000													28	58					4.22769e-11	4.94642e-11	0.116897	1	0
SLITRK4	139065	broad.mit.edu	37	X	142717182	142717182	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:142717182G>C	ENST00000381779.4	-	2	1968	c.1743C>G	c.(1741-1743)ccC>ccG	p.P581P	SLITRK4_ENST00000356928.1_Silent_p.P581P|SLITRK4_ENST00000338017.4_Silent_p.P581P	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	581	LRRCT 2.					integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TTAAAAGTTTGGGACATAAGA	0.468000													52	6					0	0	0.323286	0	0
ALMS1	7840	broad.mit.edu	37	2	73717143	73717143	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:73717143C>T	ENST00000264448.6	+	10	8165	c.8054C>T	c.(8053-8055)cCt>cTt	p.P2685L	ALMS1_ENST00000409009.1_Missense_Mutation_p.P2643L	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	2685					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						TTAGTAGAACCTGCTTTTGTG	0.398000													134	191					0	0	0.323286	0	0
SLC22A2	6582	broad.mit.edu	37	6	160662577	160662577	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:160662577C>A	ENST00000366953.3	-	9	1688	c.1430G>T	c.(1429-1431)gGt>gTt	p.G477V	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	477					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		GATGATGCCACCAATGTCACA	0.448000													41	95					8.20599e-20	1.09307e-19	0.301197	1	0
CSMD3	114788	broad.mit.edu	37	8	113662443	113662443	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:113662443G>T	ENST00000297405.5	-	19	3384	c.3140C>A	c.(3139-3141)cCc>cAc	p.P1047H	CSMD3_ENST00000455883.2_Missense_Mutation_p.P943H|CSMD3_ENST00000352409.3_Missense_Mutation_p.P1047H|CSMD3_ENST00000343508.3_Missense_Mutation_p.P1007H	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1047	Sushi 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GCATAGAAGGGGCTCTTCATG	0.413000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			86	104					1.06222e-33	1.64485e-33	0.323286	1	0
FRMPD1	22844	broad.mit.edu	37	9	37692668	37692668	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:37692668G>T	ENST00000539465.1	+	2	623	c.30G>T	c.(28-30)caG>caT	p.Q10H	FRMPD1_ENST00000377765.3_Missense_Mutation_p.Q10H|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	10						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GTTTATTCCAGACACGGAAAG	0.448000													182	674					1.81683e-88	3.28471e-88	0.323286	1	0
FOXG1	2290	broad.mit.edu	37	14	29237821	29237821	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:29237821C>A	ENST00000382535.3	+	2	1705	c.1336C>A	c.(1336-1338)Cag>Aag	p.Q446K	FOXG1_ENST00000313071.4_Missense_Mutation_p.Q446K			P55316	FOXG1_HUMAN	forkhead box G1	446				Q -> P (in Ref. 1; CAA52239).|QAPST -> AGPPRP (in Ref. 1; CAA52240 and 2; CAA55038).	axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CACGTCGCCGCAGGCCCCCTC	0.582000													16	28					3.5997e-14	4.44154e-14	0.249174	1	0
CHODL	140578	broad.mit.edu	37	21	19629135	19629135	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:19629135G>T	ENST00000299295.2	+	2	780	c.389_splice	c.e2+1	p.R130_splice	CHODL_ENST00000543733.1_Splice_Site_p.R111_splice|CHODL_ENST00000400127.1_Splice_Site_p.R89_splice|CHODL_ENST00000400128.1_Splice_Site_p.R89_splice|CHODL_ENST00000400131.1_Splice_Site_p.R89_splice|CHODL_ENST00000338326.3_Splice_Site_p.R89_splice|CHODL_ENST00000400135.1_Splice_Site_p.R89_splice	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	130	C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding	p.R89L(1)|p.R130L(1)		kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		TCCCAGTACCGGTGAGTATGG	0.522000													42	40					7.63091e-17	9.76971e-17	0.257332	1	0
KIAA1324L	222223	broad.mit.edu	37	7	86547761	86547761	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:86547761C>A	ENST00000450689.2	-	12	1775	c.1590G>T	c.(1588-1590)atG>atT	p.M530I	KIAA1324L_ENST00000416314.1_Missense_Mutation_p.M363I|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.M530I|KIAA1324L_ENST00000297222.6_Missense_Mutation_p.M290I|KIAA1324L_ENST00000490995.1_5'UTR	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	530						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					CACTTACCACCATGAAGTACA	0.428000													90	164					3.72008e-32	5.68101e-32	0.323286	1	0
KRTAP9-2	83899	broad.mit.edu	37	17	39383132	39383132	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39383132T>A	ENST00000377721.3	+	1	233	c.226T>A	c.(226-228)Tgc>Agc	p.C76S	KRTAP9-2_ENST00000455970.2_Intron	NM_031961.2	NP_114167.2	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9-2	76	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].					keratin filament	protein binding			large_intestine(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GACCAGCTGCTGCCAGCCTTC	0.642000													34	68					0	0	0.323286	0	0
LRP1B	53353	broad.mit.edu	37	2	141122288	141122288	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:141122288C>G	ENST00000389484.3	-	72	12044	c.11073G>C	c.(11071-11073)tgG>tgC	p.W3691C		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3691	LDL-receptor class A 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CATCACACACCCAGAAATGTA	0.383000										TSP Lung(27;0.18)			13	95					0	0	0.105934	0	0
OR2G3	81469	broad.mit.edu	37	1	247769078	247769078	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247769078G>C	ENST00000320002.2	+	1	223	c.191G>C	c.(190-192)aGc>aCc	p.S64T	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTTTTTCTCAGCAACCTCTCT	0.443000													382	183					0	0	0.323286	0	0
SYNPO	11346	broad.mit.edu	37	5	150028819	150028819	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:150028819G>T	ENST00000394243.1	+	3	2088	c.1714G>T	c.(1714-1716)Gcc>Tcc	p.A572S	SYNPO_ENST00000519664.1_Missense_Mutation_p.A328S|SYNPO_ENST00000522122.1_Missense_Mutation_p.A572S|SYNPO_ENST00000307662.4_Missense_Mutation_p.A328S	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	572					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTTGTCCACAGCCCCTCTGGC	0.612000													89	86					5.48297e-45	9.05157e-45	0.323286	1	0
OR14K1	343170	broad.mit.edu	37	1	247902363	247902363	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:247902363C>A	ENST00000283225.2	+	1	447	c.447C>A	c.(445-447)aaC>aaA	p.N149K	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						CCTGGCTCAACAGAGGGGCCT	0.532000													219	81					4.25211e-99	7.75547e-99	0.323286	1	0
TRBV7-6	28592	broad.mit.edu	37	7	142139451	142139451	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:142139451C>A	ENST00000390374.3	-	0	218																											GGCCCTGCCCCAGGGCCTGTC	0.512000													107	135					1.22118e-62	2.14885e-62	0.323286	1	0
BZW2	28969	broad.mit.edu	37	7	16721015	16721015	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:16721015C>A	ENST00000433922.2	+	4	503	c.325C>A	c.(325-327)Cga>Aga	p.R109R	BZW2_ENST00000258761.3_Silent_p.R109R|BZW2_ENST00000452975.2_Silent_p.R109R|BZW2_ENST00000405202.1_Silent_p.R33R	NM_001159767.1	NP_001153239.1	Q9Y6E2	BZW2_HUMAN	basic leucine zipper and W2 domains 2	109					cell differentiation|nervous system development|RNA metabolic process		protein binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(2)|ovary(2)|skin(1)|urinary_tract(1)	15	Lung NSC(10;0.0367)|all_lung(11;0.0837)			UCEC - Uterine corpus endometrioid carcinoma (126;0.199)		TGAAACCATCCGAAACTATGC	0.433000													59	49					1.73933e-33	2.69066e-33	0.323286	1	0
OR2F1	26211	broad.mit.edu	37	7	143657384	143657384	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:143657384G>T	ENST00000392899.1	+	1	358	c.321G>T	c.(319-321)ttG>ttT	p.L107F		NM_012369.2	NP_036501.2	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|skin(4)	34	Melanoma(164;0.0903)					CCCTGGCCTTGGGTGGGATTG	0.537000													109	330					6.72603e-65	1.1876e-64	0.323286	1	0
PIKFYVE	200576	broad.mit.edu	37	2	209191144	209191144	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:209191144G>T	ENST00000264380.4	+	20	3767	c.3609G>T	c.(3607-3609)tgG>tgT	p.W1203C		NM_015040.3	NP_055855.2	Q9Y2I7	FYV1_HUMAN	phosphoinositide kinase, FYVE finger containing	1203					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(14)|kidney(6)|large_intestine(25)|lung(40)|ovary(7)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	107						ATGCTGTGTGGTCAACAAAGG	0.443000													26	119					7.01153e-11	8.13285e-11	0.125774	1	0
C15orf59	388135	broad.mit.edu	37	15	74032670	74032670	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:74032670G>A	ENST00000569673.1	-	3	1674	c.470C>T	c.(469-471)cCa>cTa	p.P157L	C15orf59_ENST00000558834.1_5'UTR|C15orf59_ENST00000379822.4_Missense_Mutation_p.P157L			Q2T9L4	CO059_HUMAN	chromosome 15 open reading frame 59	157										breast(1)|endometrium(2)|large_intestine(2)|lung(6)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GGAGGAGTCTGGGGTCTCCAC	0.672000													28	45					0	0	0.125774	0	0
SCUBE3	222663	broad.mit.edu	37	6	35200627	35200627	+	Splice_Site	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:35200627A>G	ENST00000274938.7	+	5	470	c.469_splice	c.e5-1	p.E157_splice	SCUBE3_ENST00000394681.1_Splice_Site_p.E157_splice	NM_152753.2	NP_689966.2	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	157	EGF-like 4.			Missing (in Ref. 6; AAH52263).	protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(12)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	37						TCTCTTTTAGAAGGAATGAAT	0.507000													164	325					0	0	0.323286	0	0
PADI3	51702	broad.mit.edu	37	1	17601181	17601181	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:17601181G>T	ENST00000375460.3	+	11	1247	c.1207G>T	c.(1207-1209)Ggc>Tgc	p.G403C		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	403					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GTCTGTGAGTGGCCTGGACTC	0.617000											OREG0013148	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	51					1.96895e-08	2.18404e-08	0.264190	1	0
KCNMA1	3778	broad.mit.edu	37	10	78708918	78708918	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:78708918G>T	ENST00000286627.5	-	21	3469	c.2517C>A	c.(2515-2517)ccC>ccA	p.P839P	RP11-443A13.5_ENST00000426234.1_RNA|RP11-443A13.5_ENST00000600782.1_RNA|KCNMA1_ENST00000406533.3_Silent_p.P901P|KCNMA1_ENST00000404857.1_Silent_p.P880P|KCNMA1_ENST00000286628.8_Silent_p.P897P|RP11-443A13.5_ENST00000598613.1_RNA|KCNMA1_ENST00000354353.5_Silent_p.P900P|RP11-443A13.5_ENST00000458661.2_RNA|KCNMA1_ENST00000372443.1_Silent_p.P839P|KCNMA1_ENST00000404771.3_Silent_p.P897P|KCNMA1_ENST00000372440.1_Silent_p.P839P	NM_002247.3	NP_002238.2	Q12791	KCMA1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, alpha member 1	897	Segment S9.				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			breast(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(17)|lung(23)|ovary(2)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	68	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGGACACTTTGGGGAAGTTAT	0.428000													527	67					2.24488e-222	4.1882e-222	0.323286	1	0
ADAMTS19	171019	broad.mit.edu	37	5	129001264	129001264	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:129001264G>T	ENST00000274487.4	+	16	2625	c.2480G>T	c.(2479-2481)aGc>aTc	p.S827I	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	827	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		CCGGCACATAGCTATTTAGGT	0.433000													12	41					3.07112e-06	3.29908e-06	0.080935	1	0
TLK1	9874	broad.mit.edu	37	2	171871453	171871453	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:171871453C>T	ENST00000442919.2	-	13	1713	c.1098G>A	c.(1096-1098)gaG>gaA	p.E366E	TLK1_ENST00000360843.3_Silent_p.E435E|TLK1_ENST00000434911.2_Silent_p.E318E|TLK1_ENST00000521943.1_Silent_p.E366E|TLK1_ENST00000431350.2_Silent_p.E414E	NM_012290.4	NP_036422.3	Q9UKI8	TLK1_HUMAN	tousled-like kinase 1	414					cell cycle|chromatin modification|intracellular protein transport|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(8)|liver(3)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						GGATTTCTGCCTCTTCCTGAA	0.353000													157	142					0	0	0.323286	0	0
TMOD3	29766	broad.mit.edu	37	15	52181289	52181289	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:52181289A>T	ENST00000308580.7	+	5	724	c.443A>T	c.(442-444)aAg>aTg	p.K148M	TMOD3_ENST00000544199.1_Missense_Mutation_p.K148M|RP11-56B16.5_ENST00000558142.1_RNA	NM_014547.4	NP_055362.1	Q9NYL9	TMOD3_HUMAN	tropomodulin 3 (ubiquitous)	148						cytoplasm|cytoskeleton	actin binding|tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|stomach(1)	14				all cancers(107;0.00194)		ACGAATACAAAGTTCTGTAAT	0.259000													54	47					0	0	0.323286	0	0
ZNF628	89887	broad.mit.edu	37	19	55994074	55994074	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:55994074C>T	ENST00000598519.1	+	3	2067	c.1514C>T	c.(1513-1515)aCg>aTg	p.T505M	ZNF628_ENST00000391718.2_Missense_Mutation_p.T501M	NM_033113.2	NP_149104.3	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	501						nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|lung(2)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		CGGGTGCACACGGGCCTGCGG	0.692000													8	29					0	0	0.105934	0	0
PCDH17	27253	broad.mit.edu	37	13	58298838	58298838	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:58298838G>T	ENST00000377918.3	+	4	2916	c.2890G>T	c.(2890-2892)Gct>Tct	p.A964S		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	964					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGCCAATCAGGCTGAAAATGC	0.453000													47	5					3.39706e-21	4.61433e-21	0.323286	1	0
PITRM1	10531	broad.mit.edu	37	10	3212375	3212375	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:3212375C>T	ENST00000380989.2	-	2	118	c.80G>A	c.(79-81)cGa>cAa	p.R27Q	PITRM1_ENST00000451104.2_Intron|PITRM1_ENST00000224949.4_Missense_Mutation_p.R27Q	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	0					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						ACTGTTCCATCGCCACGCTCT	0.463000													10	63					0	0	0.080935	0	0
CLEC6A	93978	broad.mit.edu	37	12	8628802	8628802	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:8628802T>C	ENST00000382073.3	+	5	637	c.451T>C	c.(451-453)Tgg>Cgg	p.W151R		NM_001007033.1	NP_001007034.1	Q6EIG7	CLC6A_HUMAN	C-type lectin domain family 6, member A	151	C-type lectin.				defense response to fungus|innate immune response|positive regulation of cytokine secretion|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	sugar binding			breast(1)|large_intestine(2)|lung(7)	10	Lung SC(5;0.184)					taattggcaatggattgataa	0.363000													46	104					0	0	0.323286	0	0
COL3A1	1281	broad.mit.edu	37	2	189866155	189866155	+	Silent	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:189866155A>C	ENST00000304636.3	+	33	2486	c.2316A>C	c.(2314-2316)ccA>ccC	p.P772P	COL3A1_ENST00000317840.5_Silent_p.P772P	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	772	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CTCCTGGCCCAGCTGGCCAGC	0.378000													26	113					0	0	0.153744	0	0
TTI1	9675	broad.mit.edu	37	20	36640859	36640859	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:36640859C>A	ENST00000373448.2	-	3	1598	c.1360G>T	c.(1360-1362)Gat>Tat	p.D454Y	TTI1_ENST00000373447.3_Missense_Mutation_p.D454Y|TTI1_ENST00000449821.1_Missense_Mutation_p.D454Y|TTI1_ENST00000487362.1_5'UTR	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	454							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						TTCAGATCATCAGAGTTCCAA	0.498000													22	87					3.62473e-10	4.14236e-10	0.234183	1	0
NUTM2F	54754	broad.mit.edu	37	9	97088023	97088023	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:97088023G>C	ENST00000335456.7	-	2	230	c.210C>G	c.(208-210)ggC>ggG	p.G70G	NUTM2F_ENST00000341207.4_Silent_p.G70G|NUTM2F_ENST00000253262.4_Silent_p.G70G					NUT family member 2F																		TCGGGCCGCGGCCATCCTGTC	0.652000													9	10					0	0	0.080935	0	0
DNAH6	1768	broad.mit.edu	37	2	84924788	84924788	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:84924788G>C	ENST00000389394.3	+	47	7751	c.7614G>C	c.(7612-7614)caG>caC	p.Q2538H	DNAH6_ENST00000237449.6_Missense_Mutation_p.Q2538H|DNAH6_ENST00000398278.2_Missense_Mutation_p.Q2489H|DNAH6_ENST00000602588.1_Missense_Mutation_p.Q510H	NM_001370.1	NP_001361.1	Q9C0G6	DYH6_HUMAN	dynein, axonemal, heavy chain 6	2538	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|breast(9)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	57						AACTGGAGCAGGTTTTAGCGG	0.423000													15	9					0	0	0.132662	0	0
CPLX2	10814	broad.mit.edu	37	5	175306055	175306055	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:175306055G>A	ENST00000359546.4	+	4	819	c.176G>A	c.(175-177)cGg>cAg	p.R59Q	CPLX2_ENST00000515094.1_Missense_Mutation_p.R59Q|CPLX2_ENST00000393745.3_Missense_Mutation_p.R59Q|CPLX2_ENST00000512824.1_Missense_Mutation_p.R59Q	NM_001008220.1|NM_006650.3	NP_001008221.1|NP_006641.1	Q6PUV4	CPLX2_HUMAN	complexin 2	59	Interaction with the SNARE complex (By similarity).				mast cell degranulation|positive regulation of synaptic plasticity|vesicle docking involved in exocytosis	cytosol				endometrium(3)|kidney(2)|lung(3)|ovary(2)	10	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GAGGCGGAGCGGGAGAAGGTC	0.682000													17	19					0	0	0.175082	0	0
GAP43	2596	broad.mit.edu	37	3	115395143	115395143	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:115395143G>T	ENST00000393780.3	+	3	890	c.422G>T	c.(421-423)gGa>gTa	p.G141V	GAP43_ENST00000305124.6_Missense_Mutation_p.G105V	NM_001130064.1	NP_001123536.1	P17677	NEUM_HUMAN	growth associated protein 43	105					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell differentiation|nervous system development|regulation of filopodium assembly|regulation of growth|response to wounding	cell junction|filopodium membrane|growth cone membrane|synapse	calmodulin binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	32				GBM - Glioblastoma multiforme(114;0.164)		GGCAAAGCAGGAGAAACTCCT	0.637000													11	43					6.49762e-13	7.81784e-13	0.175082	1	0
HIST1H3A	8350	broad.mit.edu	37	6	26020720	26020720	+	Translation_Start_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:26020720G>T	ENST00000357647.3	+	1	3	c.3G>T	c.(1-3)atG>atT	p.M1I		NM_003529.2	NP_003520.1	P68431	H31_HUMAN	histone cluster 1, H3a	1					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			endometrium(1)|lung(3)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	8						TTTCCGTCATGGCTCGCACTA	0.542000													20	36					1.10513e-12	1.32402e-12	0.249174	1	0
CHL1	10752	broad.mit.edu	37	3	424321	424321	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:424321C>A	ENST00000256509.2	+	18	2785	c.2143C>A	c.(2143-2145)Cag>Aag	p.Q715K	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Missense_Mutation_p.Q699K	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	699	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TCAGCCTAGCCAGCCGTCAGA	0.443000													33	65					1.0331e-37	1.64329e-37	0.323286	1	0
UGT2B4	7363	broad.mit.edu	37	4	70360982	70360982	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:70360982C>T	ENST00000305107.6	-	1	644	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	UGT2B4_ENST00000506580.1_Intron|UGT2B4_ENST00000512583.1_Missense_Mutation_p.E200K|UGT2B4_ENST00000381096.3_Missense_Mutation_p.E64K	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	200					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						TCACTTAGTTCTGACATAACA	0.403000													65	44					0	0	0.323286	0	0
TNS1	7145	broad.mit.edu	37	2	218677108	218677108	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:218677108A>C	ENST00000171887.4	-	28	5155	c.4703T>G	c.(4702-4704)cTg>cGg	p.L1568R	TNS1_ENST00000419504.1_Missense_Mutation_p.L1554R|TNS1_ENST00000430930.1_Missense_Mutation_p.L1547R	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1568	SH2.					cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGGAATGACCAGCTTGCAAGG	0.587000													49	81					0	0	0.323286	0	0
PRR16	51334	broad.mit.edu	37	5	120022351	120022351	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:120022351G>C	ENST00000379551.2	+	3	1150	c.793G>C	c.(793-795)Gca>Cca	p.A265P	PRR16_ENST00000446965.1_Missense_Mutation_p.A218P|PRR16_ENST00000407149.2_Missense_Mutation_p.A288P|PRR16_ENST00000505123.1_Missense_Mutation_p.A218P	NM_016644.1	NP_057728.1	Q569H4	PRR16_HUMAN	proline rich 16	288	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		TCCTCCCACTGCACCAAAACC	0.433000													44	71					0	0	0.323286	0	0
GPC5	2262	broad.mit.edu	37	13	92345499	92345499	+	Missense_Mutation	SNP	T	T	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:92345499T>G	ENST00000377067.3	+	3	756	c.384T>G	c.(382-384)agT>agG	p.S128R		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	128						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TTTTTTGCAGTACCTACAGGA	0.413000													29	121					0	0	0.173368	0	0
OR7G2	390882	broad.mit.edu	37	19	9213144	9213144	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:9213144T>A	ENST00000305456.2	-	1	838	c.839A>T	c.(838-840)tAc>tTc	p.Y280F		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						AGAACTAATGTACACCCCCAA	0.468000													109	10					0	0	0.323286	0	0
PPFIA4	8497	broad.mit.edu	37	1	203015032	203015032	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:203015032G>T	ENST00000367240.2	+	8	1449	c.922G>T	c.(922-924)Gct>Tct	p.A308S	PPFIA4_ENST00000414050.2_Missense_Mutation_p.A15S|PPFIA4_ENST00000295706.4_5'UTR|PPFIA4_ENST00000447715.2_Missense_Mutation_p.A308S			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	236					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CTACCTGGCTGCTCAGCGTGA	0.582000													77	213					3.76054e-38	5.99711e-38	0.323286	1	0
PPP1R3A	5506	broad.mit.edu	37	7	113518804	113518804	+	Missense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:113518804A>T	ENST00000284601.3	-	4	2411	c.2343T>A	c.(2341-2343)gaT>gaA	p.D781E		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	781					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						AATGTGAATCATCATTTCTCC	0.388000													115	193					0	0	0.323286	0	0
EGFL6	25975	broad.mit.edu	37	X	13645250	13645250	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:13645250G>T	ENST00000361306.1	+	11	1663	c.1406G>T	c.(1405-1407)cGg>cTg	p.R469L	EGFL6_ENST00000380602.3_Missense_Mutation_p.R470L	NM_001167890.1|NM_015507.3	NP_001161362.1|NP_056322.2	Q8IUX8	EGFL6_HUMAN	EGF-like-domain, multiple 6	469	MAM.				cell adhesion|cell cycle|cell differentiation|multicellular organismal development	basement membrane|extracellular space|membrane	calcium ion binding|integrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(7)|prostate(1)|skin(3)	23						TTTGATTACCGGCTGGCCGGA	0.498000													72	65					1.37693e-34	2.14505e-34	0.323286	1	0
TRGV3	6976	broad.mit.edu	37	7	38398141	38398141	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:38398141C>A	ENST00000390346.2	-	0	508																											GTAATAGACCCCAGAATCATT	0.463000													101	322					1.1777e-47	1.96198e-47	0.323286	1	0
SPHKAP	80309	broad.mit.edu	37	2	228855715	228855715	+	Splice_Site	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:228855715C>A	ENST00000392056.3	-	11	5006		c.e11+1		SPHKAP_ENST00000344657.5_Splice_Site	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing							cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GTACATGATACCTTTTCAATT	0.428000													26	94					4.87955e-14	5.98731e-14	0.324025	1	0
CHST6	4166	broad.mit.edu	37	16	75512678	75512678	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:75512678G>A	ENST00000332272.4	-	3	1228	c.1049C>T	c.(1048-1050)gCt>gTt	p.A350V	CHST6_ENST00000390664.2_Missense_Mutation_p.A350V|RP11-77K12.4_ENST00000530512.3_RNA	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	350					keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CAGCGCACCAGCGCACAGTTC	0.642000													11	21					0	0	0.093190	0	0
TRIM33	51592	broad.mit.edu	37	1	114970493	114970493	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:114970493C>T	ENST00000358465.2	-	7	1262	c.1179G>A	c.(1177-1179)atG>atA	p.M393I	TRIM33_ENST00000450349.2_Start_Codon_SNP_p.M1I|TRIM33_ENST00000369543.2_Missense_Mutation_p.M393I	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	393	Necessary for oligomerization.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTAGTAACTTCATCTGTCTTT	0.423000			T	RET	papillary thyroid								27	62					0	0	0.116897	0	0
CALHM2	51063	broad.mit.edu	37	10	105209246	105209246	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:105209246G>T	ENST00000393235.1	-	3	1650	c.453C>A	c.(451-453)gcC>gcA	p.A151A	CALHM2_ENST00000260743.5_Silent_p.A151A|CALHM2_ENST00000369788.3_Silent_p.A151A			Q9HA72	CAHM2_HUMAN	calcium homeostasis modulator 2	151						integral to membrane				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)|skin(1)	11						CAGTGGCGTGGGCTGATGGGA	0.597000													22	36					2.48779e-11	2.92066e-11	0.324025	1	0
INPPL1	3636	broad.mit.edu	37	11	71948775	71948775	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:71948775G>T	ENST00000298229.2	+	26	3691	c.3487G>T	c.(3487-3489)Ggc>Tgc	p.G1163C	INPPL1_ENST00000541756.1_Missense_Mutation_p.G921C|INPPL1_ENST00000538751.1_Missense_Mutation_p.G921C	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	1163					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						CTCGGACTATGGCCGGCCCCT	0.697000													12	15					1.08611e-07	1.19026e-07	0.080935	1	0
CLCA1	1179	broad.mit.edu	37	1	86960013	86960013	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:86960013G>T	ENST00000234701.3	+	12	2175	c.1824G>T	c.(1822-1824)ctG>ctT	p.L608L	CLCA1_ENST00000394711.1_Silent_p.L608L			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	608					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CCAGCCCTCTGGTAGTTTATG	0.502000													88	49					7.29696e-51	1.2349e-50	0.323286	1	0
SGIP1	84251	broad.mit.edu	37	1	67142774	67142774	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:67142774C>A	ENST00000371037.4	+	13	811	c.734C>A	c.(733-735)aCt>aAt	p.T245N	SGIP1_ENST00000371035.3_Missense_Mutation_p.T202N|SGIP1_ENST00000371036.3_Missense_Mutation_p.T212N|SGIP1_ENST00000237247.6_Missense_Mutation_p.T249N|SGIP1_ENST00000371039.1_Missense_Mutation_p.T213N|SGIP1_ENST00000468286.1_3'UTR	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	245	Pro-rich.				positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						CCTTTTCCCACTGGAAGTAAG	0.393000													62	142					2.60599e-31	3.9408e-31	0.323286	1	0
ORC2	4999	broad.mit.edu	37	2	201800520	201800520	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:201800520C>A	ENST00000234296.2	-	9	859	c.610G>T	c.(610-612)Gca>Tca	p.A204S		NM_006190.4	NP_006181.1	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	204					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	20						AATATGACTGCATTAGTGTCC	0.413000													64	115					4.83874e-46	8.02226e-46	0.323286	1	0
DOCK8	81704	broad.mit.edu	37	9	376212	376212	+	Missense_Mutation	SNP	A	A	C	rs144130312		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:376212A>C	ENST00000432829.2	+	19	2224	c.1908A>C	c.(1906-1908)aaA>aaC	p.K636N	DOCK8_ENST00000382331.1_Missense_Mutation_p.K6N|DOCK8_ENST00000469391.1_Missense_Mutation_p.K636N|DOCK8_ENST00000453981.1_Missense_Mutation_p.K704N|DOCK8_ENST00000382329.1_Missense_Mutation_p.K171N	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	704					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TAACACAGAAAGTCCCATTAC	0.383000													10	274					0	0	0.058154	0	0
ROBO1	6091	broad.mit.edu	37	3	79174657	79174657	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:79174657C>A	ENST00000464233.1	-	3	234	c.121G>T	c.(121-123)Ggg>Tgg	p.G41W		NM_002941.3	NP_002932.1	Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	41					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		ATTGGCGTCCCGTGGTCGTTC	0.502000													35	94					3.09479e-21	4.2056e-21	0.246493	1	0
ZNF568	374900	broad.mit.edu	37	19	37482137	37482137	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:37482137C>T	ENST00000455427.2	+	7	602	c.273C>T	c.(271-273)caC>caT	p.H91H		NM_001204839.1	NP_001191768.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	157	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AATGCTTGCACTCTGCTCAGA	0.438000													8	14					0	0	0.278610	0	0
ACCSL	390110	broad.mit.edu	37	11	44074273	44074273	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:44074273A>G	ENST00000378832.1	+	6	890	c.834A>G	c.(832-834)gcA>gcG	p.A278A		NM_001031854.2	NP_001027025.2	Q4AC99	1A1L2_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like	278							1-aminocyclopropane-1-carboxylate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(14)|ovary(5)|pancreas(1)|skin(2)	34						GCCTGTATGCAAAGGTTGAGT	0.532000													41	680					0	0	0.323286	0	0
SZT2	23334	broad.mit.edu	37	1	43896738	43896738	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:43896738G>T	ENST00000562955.1	+	32	4722	c.4722G>T	c.(4720-4722)acG>acT	p.T1574T	SZT2_ENST00000372442.1_Silent_p.T732T	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1631						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						AGCTCCCCACGGCCTCGGACC	0.602000													42	65					3.94638e-17	5.06924e-17	0.323286	1	0
BMP5	653	broad.mit.edu	37	6	55659147	55659147	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:55659147C>A	ENST00000370830.3	-	3	1460	c.762G>T	c.(760-762)gtG>gtT	p.V254V	BMP5_ENST00000446683.2_Silent_p.V254V	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	254					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GATTGCTGGTCACAGTGATAT	0.393000													63	116					1.1362e-29	1.68687e-29	0.323286	1	0
ARHGAP22	58504	broad.mit.edu	37	10	49791025	49791025	+	Nonsense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:49791025G>T	ENST00000249601.4	-	2	503	c.207C>A	c.(205-207)taC>taA	p.Y69*	ARHGAP22_ENST00000491108.1_5'UTR|ARHGAP22_ENST00000435790.2_Nonsense_Mutation_p.Y75*|ARHGAP22_ENST00000417912.2_Nonsense_Mutation_p.Y69*	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	69	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CTTTGTCCTTGTAGTAGAAAA	0.587000													4	197					0.00909568	0.00927843	0.150653	1	0
WNT5B	81029	broad.mit.edu	37	12	1748995	1748995	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:1748995G>C	ENST00000397196.2	+	4	706	c.474G>C	c.(472-474)tgG>tgC	p.W158C	WNT5B_ENST00000537031.1_Missense_Mutation_p.W158C|WNT5B_ENST00000310594.3_Missense_Mutation_p.W158C|WNT5B_ENST00000542408.1_Intron	NM_032642.2	NP_116031.1	Q9H1J7	WNT5B_HUMAN	wingless-type MMTV integration site family, member 5B	158					angiogenesis|anterior/posterior pattern formation|cell migration involved in gastrulation|cellular response to retinoic acid|chondrocyte differentiation|convergent extension involved in axis elongation|convergent extension involved in gastrulation|dorsal/ventral axis specification|endocrine pancreas development|fat cell differentiation|lens fiber cell development|negative regulation of canonical Wnt receptor signaling pathway|neuron differentiation|positive regulation of cell migration|positive regulation of fat cell differentiation|respiratory system development|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled-2 binding			skin(1)	1	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.00109)			ACTGGCTGTGGGGCGGCTGTG	0.677000													5	7					0	0	0.278610	0	0
TRPV2	51393	broad.mit.edu	37	17	16338250	16338250	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:16338250C>T	ENST00000338560.7	+	14	2560	c.2161C>T	c.(2161-2163)Ctg>Ttg	p.L721L	TRPV2_ENST00000577397.1_Silent_p.L291L	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	721					sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		GCTGCCTACGCTGTGTGAGGA	0.627000													26	31					0	0	0.173368	0	0
DPYSL3	1809	broad.mit.edu	37	5	146792222	146792222	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:146792222C>A	ENST00000343218.5	-	6	1109	c.912G>T	c.(910-912)gaG>gaT	p.E304D	DPYSL3_ENST00000398514.3_Missense_Mutation_p.E190D|DPYSL3_ENST00000534907.1_Intron	NM_001197294.1	NP_001184223.1	Q14195	DPYL3_HUMAN	dihydropyrimidinase-like 3	190					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol|growth cone	dihydropyrimidinase activity			breast(2)|endometrium(1)|kidney(4)|large_intestine(6)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCCCCCAGCTCTCCCAGGC	0.507000													13	23					1.5842e-08	1.76294e-08	0.105934	1	0
CSRP2BP	57325	broad.mit.edu	37	20	18168094	18168094	+	Silent	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:18168094C>A	ENST00000278816.2	+	11	2990	c.2340C>A	c.(2338-2340)ctC>ctA	p.L780L	CSRP2BP_ENST00000435364.2_Silent_p.L780L|CSRP2BP_ENST00000377681.2_Silent_p.L779L|CSRP2BP_ENST00000489634.2_Silent_p.L652L			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	780	N-acetyltransferase.				histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						TTCTGAGGCTCCGGCGCTGAT	0.418000													22	26					1.9806e-07	2.16899e-07	0.249174	1	0
HOXD3	3232	broad.mit.edu	37	2	177036370	177036370	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:177036370C>T	ENST00000468418.3	+	4	2757	c.667C>T	c.(667-669)Cgc>Tgc	p.R223C	HOXD3_ENST00000410016.1_Missense_Mutation_p.R223C|HOXD3_ENST00000249440.3_Missense_Mutation_p.R223C			P31249	HXD3_HUMAN	homeobox D3	223					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		GTGCCGGCCGCGCCGCGTGGA	0.587000													37	95					0	0	0.257332	0	0
FUT6	2528	broad.mit.edu	37	19	5832192	5832192	+	Silent	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:5832192C>T	ENST00000318336.4	-	3	1581	c.387G>A	c.(385-387)caG>caA	p.Q129Q	FUT6_ENST00000524754.1_Silent_p.Q129Q|FUT6_ENST00000286955.5_Silent_p.Q129Q|FUT6_ENST00000592563.1_Silent_p.Q129Q|FUT6_ENST00000527106.1_Silent_p.Q129Q	NM_000150.2	NP_000141.1	P51993	FUT6_HUMAN	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)	129					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(2)	6						AGATCCATCGCTGCCCCTGCC	0.617000													28	2					0	0	0.144211	0	0
APPBP2	10513	broad.mit.edu	37	17	58529351	58529351	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:58529351T>A	ENST00000083182.3	-	12	1681	c.1394A>T	c.(1393-1395)cAa>cTa	p.Q465L		NM_006380.2	NP_006371.2	Q92624	APBP2_HUMAN	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	465					intracellular protein transport	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|nucleus	microtubule motor activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(17)|pancreas(1)|urinary_tract(1)	25	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.67e-13)|all cancers(12;1.44e-11)|Colorectal(3;0.01)			ATAATCTTCTTGACCAAGAAG	0.328000													34	86					0	0	0.203993	0	0
APLP2	334	broad.mit.edu	37	11	129996650	129996650	+	Silent	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:129996650A>T	ENST00000263574.5	+	8	1218	c.1146A>T	c.(1144-1146)gcA>gcT	p.A382A	APLP2_ENST00000345598.5_Silent_p.A153A|APLP2_ENST00000528499.1_Silent_p.A326A|APLP2_ENST00000278756.7_Silent_p.A392A|APLP2_ENST00000539648.1_Silent_p.A170A|APLP2_ENST00000543137.1_Silent_p.A289A|APLP2_ENST00000338167.5_Silent_p.A382A	NM_001642.2	NP_001633.1	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	382					G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(6)|ovary(4)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		AGACCTCTGCAGATGATAATG	0.468000													161	117					0	0	0.323286	0	0
FAM214B	80256	broad.mit.edu	37	9	35105288	35105288	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:35105288G>A	ENST00000378561.1	-	8	4602	c.1547C>T	c.(1546-1548)aCa>aTa	p.T516I	FAM214B_ENST00000605244.1_Missense_Mutation_p.T516I|FAM214B_ENST00000488109.2_Missense_Mutation_p.T516I|FAM214B_ENST00000378557.1_Missense_Mutation_p.T516I|FAM214B_ENST00000378566.1_Missense_Mutation_p.T211I|FAM214B_ENST00000378554.2_Intron|FAM214B_ENST00000603301.1_Missense_Mutation_p.T516I|FAM214B_ENST00000322813.5_Missense_Mutation_p.T516I			Q7L5A3	K1539_HUMAN	family with sequence similarity 214, member B	516						nucleus											GGGGAGCCCTGTGTCCAGCTC	0.592000													18	72					0	0	0.249174	0	0
SPDYC	387778	broad.mit.edu	37	11	64938909	64938909	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:64938909G>T	ENST00000377185.2	+	2	220	c.138G>T	c.(136-138)ggG>ggT	p.G46G		NM_001008778.1	NP_001008778.1	Q5MJ68	SPDYC_HUMAN	speedy/RINGO cell cycle regulator family member C	46					cell cycle	nucleus	protein kinase binding			breast(1)|endometrium(3)|large_intestine(2)|lung(9)|prostate(1)	16						GGCAAGGTGGGGGCAATGGGT	0.627000													16	33					6.49762e-13	7.81784e-13	0.175082	1	0
CACNA1A	773	broad.mit.edu	37	19	13419011	13419011	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:13419011G>T	ENST00000360228.5	-	14	1835	c.1836C>A	c.(1834-1836)tcC>tcA	p.S612S	CACNA1A_ENST00000573710.2_Silent_p.S613S	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	613					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GGCTGATGATGGACTTCATGG	0.552000													51	1					2.73381e-35	4.27606e-35	0.323286	1	0
FTSJ3	117246	broad.mit.edu	37	17	61897779	61897779	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:61897779C>A	ENST00000427159.2	-	19	2737	c.2092G>T	c.(2092-2094)Gag>Tag	p.E698*		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	698					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						AGCTCCCCCTCATCCTCATTA	0.498000													75	167					9.46827e-25	1.34018e-24	0.323286	1	0
RELN	5649	broad.mit.edu	37	7	103234239	103234239	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:103234239T>A	ENST00000424685.2	-	27	3961	c.3802A>T	c.(3802-3804)Acc>Tcc	p.T1268S	RELN_ENST00000428762.1_Missense_Mutation_p.T1268S|RELN_ENST00000343529.5_Missense_Mutation_p.T1268S			P78509	RELN_HUMAN	reelin	1268					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GCACAGAAGGTTTCATTTTTA	0.388000													14	122					0	0	0.119110	0	0
KIAA1804	84451	broad.mit.edu	37	1	233511714	233511714	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:233511714A>G	ENST00000366624.3	+	7	1989	c.1728A>G	c.(1726-1728)caA>caG	p.Q576Q	MLK4_ENST00000366622.1_Silent_p.Q22Q	NM_032435.2	NP_115811.2																					TCTTTCGACAAGAAGAATTTG	0.328000													84	56					0	0	0.323286	0	0
RAB6C	84084	broad.mit.edu	37	2	130738129	130738129	+	Silent	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:130738129G>A	ENST00000410061.2	+	1	895	c.441G>A	c.(439-441)ggG>ggA	p.G147G		NM_032144.2	NP_115520.2	Q9H0N0	RAB6C_HUMAN	RAB6C, member RAS oncogene family	147					protein transport|response to drug|small GTPase mediated signal transduction		GTP binding|GTPase activity			large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	5	Colorectal(110;0.1)					AAGCCAAAGGGCTGAATGTTA	0.453000													295	651					0	0	0.323286	0	0
CACNA2D3	55799	broad.mit.edu	37	3	55043458	55043458	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:55043458A>G	ENST00000474759.1	+	34	2911	c.2863A>G	c.(2863-2865)Atg>Gtg	p.M955V	CACNA2D3_ENST00000490478.1_Missense_Mutation_p.M861V|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.M955V|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.M955V|CACNA2D3_ENST00000478261.1_3'UTR	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	955						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		GCACTCCGATATGACAGCTAA	0.493000													50	135					0	0	0.323286	0	0
RAB5C	5878	broad.mit.edu	37	17	40280746	40280746	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:40280746T>A	ENST00000393860.3	-	4	555	c.239A>T	c.(238-240)cAg>cTg	p.Q80L	RAB5C_ENST00000346213.4_Missense_Mutation_p.Q80L|RAB5C_ENST00000547517.1_Missense_Mutation_p.Q113L|CTD-2132N18.3_ENST00000592574.1_Missense_Mutation_p.Q80L	NM_201434.2	NP_958842.1	P51148	RAB5C_HUMAN	RAB5C, member RAS oncogene family	80					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|plasma membrane	GTP binding|GTPase activity|protein binding			large_intestine(1)|lung(4)|prostate(1)|skin(1)	7		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.128)		ATACCGCTCCTGTCCAGCTGT	0.557000													71	159					0	0	0.323286	0	0
KRTAP4-2	85291	broad.mit.edu	37	17	39334236	39334236	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39334236A>G	ENST00000377726.2	-	1	224	c.181T>C	c.(181-183)Tgc>Cgc	p.C61R		NM_033062.3	NP_149051.1	Q9BYR5	KRA42_HUMAN	keratin associated protein 4-2	61	20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]- [VSTQ].					keratin filament				kidney(2)|lung(4)|upper_aerodigestive_tract(1)	7		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			CTGGGGCTGCAGCAGGTGGGC	0.662000													40	58					0	0	0.323286	0	0
DNAH7	56171	broad.mit.edu	37	2	196791236	196791236	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:196791236T>A	ENST00000312428.6	-	22	3626	c.3526A>T	c.(3526-3528)Agg>Tgg	p.R1176W		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1176	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GGCCAATCCCTTACCCAGTTA	0.353000													43	104					0	0	0.323286	0	0
CATSPER3	347732	broad.mit.edu	37	5	134332105	134332105	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:134332105G>T	ENST00000282611.6	+	3	481	c.395G>T	c.(394-396)cGc>cTc	p.R132L		NM_178019.2	NP_821138.1	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	132					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|stomach(1)|urinary_tract(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TATGCCCTCCGCCAGCTCATG	0.507000													49	40					1.19451e-25	1.70952e-25	0.323286	1	0
GABRG1	2565	broad.mit.edu	37	4	46066476	46066476	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:46066476G>T	ENST00000295452.4	-	5	774	c.607C>A	c.(607-609)Cca>Aca	p.P203T		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	203					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		AATTCCAGTGGACAGGAATGT	0.269000													9	65					0.00010058	0.000105699	0.093190	1	0
NLRP1	22861	broad.mit.edu	37	17	5462876	5462876	+	Silent	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:5462876G>C	ENST00000345221.3	-	4	1694	c.1140C>G	c.(1138-1140)ctC>ctG	p.L380L	NLRP1_ENST00000354411.3_Silent_p.L380L|NLRP1_ENST00000262467.5_Silent_p.L380L|NLRP1_ENST00000572272.1_Silent_p.L380L|NLRP1_ENST00000577119.1_Silent_p.L380L|NLRP1_ENST00000571307.1_5'UTR|NLRP1_ENST00000269280.4_Silent_p.L380L	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	380	NACHT.				defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				TGAGCTCAGCGAGACTCACCA	0.577000													61	8					0	0	0.323286	0	0
SMOX	54498	broad.mit.edu	37	20	4162573	4162573	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:4162573C>T	ENST00000305958.4	+	4	784	c.559C>T	c.(559-561)Cca>Tca	p.P187S	SMOX_ENST00000379460.2_Missense_Mutation_p.P187S|SMOX_ENST00000339123.6_Missense_Mutation_p.P187S|SMOX_ENST00000278795.3_Missense_Mutation_p.P187S|SMOX_ENST00000484515.1_3'UTR|SMOX_ENST00000346595.2_Intron	NM_175839.1	NP_787033.1	Q9NWM0	SMOX_HUMAN	spermine oxidase	187					polyamine biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	polyamine oxidase activity			breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(7)|lung(5)|skin(2)|urinary_tract(1)	26					Spermine(DB00127)	CCCTGACGACCCAGAGGCTAC	0.562000													48	60					0	0	0.323286	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605066	140605066	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:140605066G>T	ENST00000239449.4	+	1	1989	c.1989G>T	c.(1987-1989)gtG>gtT	p.V663V	PCDHB14_ENST00000515856.2_Silent_p.V510V	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		663	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTCCTGGTGGACGGCTTCT	0.711000													3	19					0.0809354	0.0820481	0.080935	1	0
IFNG	3458	broad.mit.edu	37	12	68553297	68553297	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:68553297G>T	ENST00000229135.3	-	1	230	c.99C>A	c.(97-99)aaC>aaA	p.N33K	IFNG-AS1_ENST00000536914.1_RNA	NM_000619.2	NP_000610.2	P01579	IFNG_HUMAN	interferon, gamma	33					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	ATTTCTTAAGGTTTTCTGCTT	0.363000													7	12					8.12818e-05	8.55061e-05	0.248553	1	0
EPHB2	2048	broad.mit.edu	37	1	23101737	23101737	+	Splice_Site	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:23101737G>T	ENST00000374627.1	+	1	67	c.43_splice	c.e1+1	p.E15_splice	EPHB2_ENST00000374632.3_Intron|EPHB2_ENST00000400191.3_Intron|EPHB2_ENST00000374630.3_Intron|EPHB2_ENST00000544305.1_Intron			P29323	EPHB2_HUMAN	EPH receptor B2	21				MALRRLGAALLLLPLLAAVE -> MWVPVLALPVCTYA (in Ref. 1; BAA06506).	axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		cacttatgcaggttggttctc	0.453000													24	76					2.65835e-16	3.37829e-16	0.125774	1	0
FAM74A3	728495	broad.mit.edu	37	9	40716228	40716228	+	RNA	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:40716228T>A	ENST00000604146.1	+	0	567					NR_026801.1															endometrium(1)|large_intestine(2)|lung(6)|skin(1)	10				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		CTGCTGCACTTGGCTGTTTTT	0.433000													80	72					0	0	0.323286	0	0
USH2A	7399	broad.mit.edu	37	1	216074110	216074110	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:216074110G>T	ENST00000366943.2	-	39	7824	c.7438C>A	c.(7438-7440)Cat>Aat	p.H2480N	USH2A_ENST00000307340.3_Missense_Mutation_p.H2480N|RP5-1111A8.3_ENST00000414995.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2480	Fibronectin type-III 11.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGAAATCCATGGGTGGAGTCG	0.453000										HNSCC(13;0.011)			151	66					2.1928e-39	3.52601e-39	0.323286	1	0
NALCN	259232	broad.mit.edu	37	13	101710324	101710324	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:101710324G>A	ENST00000251127.6	-	43	5071	c.4990C>T	c.(4990-4992)Cag>Tag	p.Q1664*	NALCN-AS1_ENST00000457843.1_RNA	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1664						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AATTTCCTCTGGGGTTTCCCT	0.557000													64	184					0	0	0.323286	0	0
CYP4F3	4051	broad.mit.edu	37	19	15760797	15760797	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:15760797T>A	ENST00000221307.7	+	7	770	c.722T>A	c.(721-723)cTg>cAg	p.L241Q	CYP4F3_ENST00000592424.1_3'UTR|CYP4F3_ENST00000591058.1_Missense_Mutation_p.L241Q|CYP4F3_ENST00000585846.1_Missense_Mutation_p.L241Q|CYP4F3_ENST00000586182.1_Missense_Mutation_p.L241Q	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	241					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CAGATCCTCCTGTACATAGAC	0.557000													328	207					0	0	0.323286	0	0
FGA	2243	broad.mit.edu	37	4	155505620	155505620	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:155505620G>T	ENST00000302053.3	-	6	2335	c.2257C>A	c.(2257-2259)Ctc>Atc	p.L753I		NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	753	Fibrinogen C-terminal.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GAGACTTGGAGGGCATAGCCT	0.522000													100	39					1.70349e-48	2.85174e-48	0.323286	1	0
ADAMTS15	170689	broad.mit.edu	37	11	130341207	130341207	+	Silent	SNP	C	C	T	rs139750111	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:130341207C>T	ENST00000299164.2	+	7	2007	c.2007C>T	c.(2005-2007)ttC>ttT	p.F669F		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	669	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		AGAAGAGATTCGACAAGTGTG	0.572000													13	42					0	0	0.105934	0	0
PHC2	1912	broad.mit.edu	37	1	33794655	33794655	+	Silent	SNP	A	A	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:33794655A>G	ENST00000257118.5	-	13	2291	c.2238T>C	c.(2236-2238)taT>taC	p.Y746Y	PHC2_ENST00000373422.3_Silent_p.Y352Y|PHC2_ENST00000431992.1_Silent_p.Y717Y|PHC2_ENST00000373416.1_Silent_p.Y211Y|PHC2_ENST00000485928.1_5'UTR|PHC2_ENST00000419414.2_Silent_p.Y747Y|PHC2_ENST00000373418.3_Silent_p.Y211Y	NM_198040.2	NP_932157.1	Q8IXK0	PHC2_HUMAN	polyhomeotic homolog 2 (Drosophila)	746					multicellular organismal development	PcG protein complex	DNA binding|identical protein binding|zinc ion binding			autonomic_ganglia(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGGGTTCCTCATAGCTTGAGT	0.592000													23	53					0	0	0.279207	0	0
LIX1L	128077	broad.mit.edu	37	1	145487437	145487437	+	Silent	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:145487437G>T	ENST00000369308.3	+	2	500	c.426G>T	c.(424-426)ctG>ctT	p.L142L	RP11-315I20.1_ENST00000600340.1_RNA|RP11-315I20.1_ENST00000599469.1_RNA|RP11-315I20.1_ENST00000598354.1_RNA|RP11-315I20.1_ENST00000598103.1_RNA|RP11-315I20.1_ENST00000597144.1_RNA|RP11-315I20.1_ENST00000437207.1_RNA	NM_153713.1	NP_714924.1	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse)-like	142										large_intestine(4)|lung(6)|ovary(2)|skin(1)	13	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ATGTCACCCTGCCTGGGGGAA	0.493000													41	105					6.68952e-21	9.05483e-21	0.312237	1	0
LYST	1130	broad.mit.edu	37	1	235918832	235918832	+	Nonsense_Mutation	SNP	A	A	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:235918832A>T	ENST00000389794.3	-	25	7349	c.7175T>A	c.(7174-7176)tTg>tAg	p.L2392*	LYST_ENST00000389793.2_Nonsense_Mutation_p.L2392*			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2392					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			GCATTCTAACAATTCTTGAGT	0.373000													131	425					0	0	0.323286	0	0
C1orf51	148523	broad.mit.edu	37	1	150259052	150259052	+	Missense_Mutation	SNP	G	G	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:150259052G>T	ENST00000290363.5	+	5	1293	c.844G>T	c.(844-846)Ggt>Tgt	p.G282C	C1orf51_ENST00000369095.1_Missense_Mutation_p.G282C|C1orf51_ENST00000369094.1_Missense_Mutation_p.G194C	NM_144697.2	NP_653298.1	Q8N365	CA051_HUMAN	chromosome 1 open reading frame 51	282										endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(2)	10	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTTTAGCCATGGTCCTTTAGG	0.562000													7	553					0.000157383	0.000164723	0.278610	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37490217	37490217	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:37490217C>A	ENST00000374660.1	+	37	3121	c.3022C>A	c.(3022-3024)Caa>Aaa	p.Q1008K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.Q889K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.Q889K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1032						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GGCTACACATCAAAAAGAAAT	0.318000													36	155					3.38236e-24	4.77228e-24	0.246493	1	0
NPY1R	4886	broad.mit.edu	37	4	164246613	164246613	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:164246613A>C	ENST00000296533.2	-	3	1528	c.997T>G	c.(997-999)Ttc>Gtc	p.F333V	NPY1R_ENST00000509586.1_Missense_Mutation_p.F90V	NM_000909.5	NP_000900.1	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	333					inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			breast(1)|cervix(1)|large_intestine(4)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)	30	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TTGAAGAAGAACTGCAAGTCT	0.418000													4	91					0	0	0.150653	0	0
DDX58	23586	broad.mit.edu	37	9	32481382	32481382	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:32481382T>A	ENST00000379882.1	-	10	1616	c.1459A>T	c.(1459-1461)Agc>Tgc	p.S487C	DDX58_ENST00000379883.2_Missense_Mutation_p.S532C|DDX58_ENST00000545044.1_Missense_Mutation_p.S329C|DDX58_ENST00000379868.1_Missense_Mutation_p.S329C|DDX58_ENST00000542096.1_Missense_Mutation_p.S461C			O95786	DDX58_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	532					detection of virus|innate immune response|negative regulation of type I interferon production|positive regulation of defense response to virus by host|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter	cytosol	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|protein binding|zinc ion binding			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;0.00056)		CAAATCCTGCTCTCTTCATCT	0.408000													130	47					0	0	0.323286	0	0
OR4N5	390437	broad.mit.edu	37	14	20612013	20612013	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20612013C>A	ENST00000333629.1	+	1	119	c.119C>A	c.(118-120)cCt>cAt	p.P40H		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		ATCATCCTCCCTGGAAATTTC	0.453000													384	337					1.23243e-189	2.29378e-189	0.323286	1	0
RGS9	8787	broad.mit.edu	37	17	63221338	63221338	+	Nonsense_Mutation	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:63221338C>A	ENST00000449996.3	+	18	1689	c.1617C>A	c.(1615-1617)tgC>tgA	p.C539*	RGS9_ENST00000262406.9_Nonsense_Mutation_p.C542*|RGS9_ENST00000443584.3_Nonsense_Mutation_p.C539*	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	542					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						AAGGGGAGTGCAGCGGGTCCA	0.692000													79	195					1.63847e-34	2.5512e-34	0.323286	1	0
HMGB1P5	10354	broad.mit.edu	37	3	22424047	22424047	+	RNA	SNP	C	C	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:22424047C>A	ENST00000451497.1	+	0	612																											AAATGTAAGGCGGTGTAAGAT	0.333000													24	102					1.10923e-09	1.25789e-09	0.264190	1	0
ZAN	7455	broad.mit.edu	37	7	100391854	100391854	+	RNA	SNP	G	G	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100391854G>C	ENST00000542585.1	+	0	8309				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000449052.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCACCCTGGGGAACCACACC	0.637000													18	112					0	0	0.234183	0	0
RP1-37J18.2	0	broad.mit.edu	37	1	4640919	4640919	+	RNA	DEL	T	T	-	rs5772169		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:4640919delT	ENST00000420522.1	+	0	205																											tatctgcccctgatgatttat	0.393													6	4	---	---	---	---					
CROCCP2	84809	broad.mit.edu	37	1	16960418	16960418	+	RNA	DEL	A	A	-	rs59476808		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:16960418delA	ENST00000412962.1	-	0	16																											tcagattgggaaaaaaaaaaa	0.453													7	8	---	---	---	---					
PPIEL	728448	broad.mit.edu	37	1	39991730	39991731	+	RNA	INS	-	-	GAGT	rs142640325	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:39991730_39991731insGAGT	ENST00000458207.1	-	0	241				RP11-69E11.4_ENST00000431553.1_RNA|RP11-69E11.4_ENST00000417869.1_RNA|RP11-69E11.4_ENST00000440190.1_RNA|RP11-69E11.4_ENST00000450157.1_RNA																							TGCACTGTCTGGAGTCAGCACA	0.589													2	4	---	---	---	---					
SLC2A1-AS1	440584	broad.mit.edu	37	1	43448261	43448262	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:43448261_43448262insT	ENST00000431759.1	+	0	890					NR_033967.1																						ttaggttgtaatttttGTATGC	0.332													2	4	---	---	---	---					
SZT2	23334	broad.mit.edu	37	1	43890848	43890849	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:43890848_43890849insC	ENST00000562955.1	+	18	2615_2616	c.2615_2616insC	c.(2614-2616)tccfs	p.S872fs	SZT2_ENST00000372442.1_Frame_Shift_Ins_p.S30fs	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	872						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						TACATCCTCTTCCCCCCACACT	0.574													8	270	---	---	---	---					
FAAHP1	729041	broad.mit.edu	37	1	46909055	46909057	+	RNA	DEL	CTC	CTC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:46909055_46909057delCTC	ENST00000429784.2	+	0	454					NR_045483.1																						ttttcttcttctcctcctcctcc	0.571													3	4	---	---	---	---					
RP11-117D22.2	0	broad.mit.edu	37	1	53833725	53833727	+	RNA	DEL	CTT	CTT	-	rs3831295		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:53833725_53833727delCTT	ENST00000449958.1	-	0	190_192																											CAGATGCAACCTTCTTCACGAAA	0.493													5	1	---	---	---	---					
RP11-466L17.1	0	broad.mit.edu	37	1	56115222	56115223	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:56115222_56115223insT	ENST00000422374.1	+	0	240																											TTGTTGTTTTCTTTTTTTTCTG	0.307													2	4	---	---	---	---					
RP11-90C4.2	0	broad.mit.edu	37	1	56386417	56386417	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:56386417delG	ENST00000458145.1	-	0	95																											tgggaaggaaggaggctattg	0.498													7	12	---	---	---	---					
RP11-575B7.3	0	broad.mit.edu	37	1	60584282	60584282	+	RNA	DEL	T	T	-	rs68039873		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:60584282delT	ENST00000456878.1	+	0	99																											gagggaagacttttttattcc	0.403													4	9	---	---	---	---					
RP11-776H12.1	0	broad.mit.edu	37	1	61081821	61081821	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:61081821delA	ENST00000439156.2	-	0	336																											GAATTGGAGTAAAAAAAAATG	0.294													2	4	---	---	---	---					
L1TD1	54596	broad.mit.edu	37	1	62672596	62672597	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:62672596_62672597delGG	ENST00000498273.1	+	3	591_592	c.296_297delGG	c.(295-297)afs	p.R99fs		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	99										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						TCCAGTAGTAGGACagagtttc	0.347													21	73	---	---	---	---					
LINC00466	199899	broad.mit.edu	37	1	63692970	63692970	+	RNA	DEL	C	C	-	rs66739610		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:63692970delC	ENST00000455304.2	-	0	257																											cttttcttttctttttttttt	0.383													2	4	---	---	---	---					
LOC101927244	101927244	broad.mit.edu	37	1	71212238	71212239	+	RNA	INS	-	-	TTT	rs139537673		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:71212238_71212239insTTT	ENST00000419450.1	+	0	637																											accagcacctgttttttttttt	0.347													3	4	---	---	---	---					
RP4-660H19.1	0	broad.mit.edu	37	1	73221591	73221591	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:73221591delC	ENST00000445976.1	-	0	280																											AATGGGCCTACAAACTAatct	0.333													3	6	---	---	---	---					
RP11-131L23.1	0	broad.mit.edu	37	1	85752851	85752852	+	RNA	DEL	GG	GG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:85752851_85752852delGG	ENST00000427819.1	+	0	181				RP11-131L23.1_ENST00000426125.1_RNA																							ATTtgaacttgggtcttcattt	0.401													2	4	---	---	---	---					
PKN2-AS1	101927891	broad.mit.edu	37	1	89021651	89021651	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:89021651delA	ENST00000458097.1	-	0	395				RP11-76N22.2_ENST00000425750.2_RNA																							TTCCCAGTTTAAAAAAAAAAA	0.358													2	4	---	---	---	---					
RP11-202K23.1	0	broad.mit.edu	37	1	102703367	102703368	+	RNA	DEL	AC	AC	-	rs72343663		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:102703367_102703368delAC	ENST00000447916.1	-	0	398																											gaatatatgtacacacacacac	0.337													6	10	---	---	---	---					
RP11-24P14.1	0	broad.mit.edu	37	1	106474982	106474983	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:106474982_106474983insA	ENST00000446693.1	-	0	463																											cctgcaaagccacaggagcaga	0.510													3	6	---	---	---	---					
LOC440600	440600	broad.mit.edu	37	1	110843799	110843799	+	RNA	DEL	T	T	-	rs35229578		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:110843799delT	ENST00000449169.1	-	0	293					NR_036595.1																						Ctttatttaattttttttttt	0.303													3	3	---	---	---	---					
RP4-663N10.1	0	broad.mit.edu	37	1	115893990	115893991	+	RNA	INS	-	-	GT	rs80245094	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:115893990_115893991insGT	ENST00000425449.1	+	0	207																											tatgtgtgtgcgtgtgtgtgtg	0.436													3	4	---	---	---	---					
LINC01525	104355292	broad.mit.edu	37	1	117850281	117850281	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:117850281delG	ENST00000442182.1	+	0	298																											caaaagtacaggcaaggagtg	0.393													4	4	---	---	---	---					
RP11-418J17.3	0	broad.mit.edu	37	1	119853873	119853874	+	RNA	INS	-	-	A	rs11361145		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:119853873_119853874insA	ENST00000457719.1	-	0	341																											agactctgtttaaaaaaaaaaa	0.505													3	3	---	---	---	---					
ADAM30	11085	broad.mit.edu	37	1	120437196	120437197	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:120437196_120437197insC	ENST00000369400.1	-	1	1921_1922	c.1763_1764insG	c.(1762-1764)gacfs	p.D588fs		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	588	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GATAGCCTGTGCCCCAGCACAT	0.431													67	165	---	---	---	---					
AL592494.5	0	broad.mit.edu	37	1	121160438	121160438	+	RNA	DEL	A	A	-	rs113685449		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:121160438delA	ENST00000417218.1	+	0	551				RP11-343N15.2_ENST00000445260.2_lincRNA																							ggagagggagagggggagggg	0.522													6	8	---	---	---	---					
AL592494.5	0	broad.mit.edu	37	1	121161182	121161182	+	RNA	DEL	T	T	-	rs58177605		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:121161182delT	ENST00000417218.1	+	0	551				RP11-343N15.2_ENST00000445260.2_lincRNA																							tctttctttcttttttctttc	0.378													3	5	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142627659	142627660	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:142627659_142627660insT	ENST00000369381.2	-	0	5218				RP11-417J8.3_ENST00000426408.1_lincRNA																							cattttgtaggttgcctgttca	0.347													4	8	---	---	---	---					
LOC101927209	101927209	broad.mit.edu	37	1	142648461	142648462	+	RNA	INS	-	-	T	rs149586890		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:142648461_142648462insT	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							taatttttgtattttttttttg	0.475													3	6	---	---	---	---					
LOC101927648	101927648	broad.mit.edu	37	1	143411083	143411084	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:143411083_143411084insA	ENST00000423249.1	-	0	59																											ctgcaggctgtaaaaaaaaaag	0.381													2	4	---	---	---	---					
LOC400794	400794	broad.mit.edu	37	1	165493480	165493481	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:165493480_165493481insC	ENST00000438275.1	-	0	1032				RP11-280O1.2_ENST00000415000.1_RNA|RP11-280O1.2_ENST00000416424.1_RNA|RP11-280O1.2_ENST00000452283.1_RNA|RP11-280O1.2_ENST00000421273.1_RNA																							acagccccaaaccCCCAAGTAT	0.450													2	4	---	---	---	---					
RP11-306I1.2	0	broad.mit.edu	37	1	165585283	165585283	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:165585283delA	ENST00000452618.1	+	0	315																											tactctgtctaaaaaaaaaaa	0.398													2	4	---	---	---	---					
RP11-306I1.2	0	broad.mit.edu	37	1	165591423	165591424	+	RNA	INS	-	-	A	rs11369100		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:165591423_165591424insA	ENST00000452618.1	+	0	405																											gactccatctcaaaaaaaaaaa	0.396													10	5	---	---	---	---					
LOC101928565	101928565	broad.mit.edu	37	1	168433621	168433622	+	RNA	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:168433621_168433622insG	ENST00000422253.1	-	0	359																											gctgagaaaaagggggaaaagc	0.470													2	4	---	---	---	---					
RP1-10C16.1	0	broad.mit.edu	37	1	168738019	168738019	+	RNA	DEL	T	T	-	rs11285882		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:168738019delT	ENST00000457405.1	-	0	166																											tttttctttcttttttttttt	0.393													3	4	---	---	---	---					
LINC00970	101978719	broad.mit.edu	37	1	168927908	168927908	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:168927908delG	ENST00000366408.3	-	0	209																											AAACATCTCAGGTACTTTTAG	0.468													4	4	---	---	---	---					
PRRC2C	23215	broad.mit.edu	37	1	171501704	171501704	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:171501704delA	ENST00000367742.3	+	12	1719	c.1477delA	c.(1477-1479)agfs	p.K493fs	PRRC2C_ENST00000338920.4_Frame_Shift_Del_p.K491fs|PRRC2C_ENST00000426496.2_Frame_Shift_Del_p.K491fs|PRRC2C_ENST00000476522.1_3'UTR|PRRC2C_ENST00000392078.3_Frame_Shift_Del_p.K493fs			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	491	Glu-rich.						protein C-terminus binding										ATTGGATGAGAAGCTTGGCAT	0.463													30	16	---	---	---	---					
LINC01036	104169671	broad.mit.edu	37	1	187300646	187300646	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:187300646delA	ENST00000458683.1	+	0	249																											CAGtgtagagaaaaaaattat	0.279													2	4	---	---	---	---					
LOC440704	440704	broad.mit.edu	37	1	190653138	190653143	+	RNA	DEL	TGTGTG	TGTGTG	-	rs58252488		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:190653138_190653143delTGTGTG	ENST00000413356.1	+	0	144					NR_033922.1																						tatgggtaattgtgtgtgtgtgtgtg	0.330													4	5	---	---	---	---					
LOC440704	440704	broad.mit.edu	37	1	190754021	190754022	+	RNA	INS	-	-	A	rs149651301	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:190754021_190754022insA	ENST00000413356.1	+	0	217					NR_033922.1																						aggcagaaatcaaaaaaaatat	0.287													2	4	---	---	---	---					
LINC01221	104266961	broad.mit.edu	37	1	199045518	199045518	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:199045518delA	ENST00000432488.1	+	0	450																											ATCTTCTTGCAAAAATAAGCT	0.338													4	6	---	---	---	---					
RP11-168O16.2	0	broad.mit.edu	37	1	201008582	201008583	+	RNA	INS	-	-	G	rs146852333	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:201008582_201008583insG	ENST00000415359.1	+	0	210																											GGGAAGGGACTGGGGAGGGGGA	0.554													11	2	---	---	---	---					
CACNA1S	779	broad.mit.edu	37	1	201061223	201061223	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:201061223delC	ENST00000362061.3	-	4	644	c.418delG	c.(418-420)aafs	p.E140fs	CACNA1S_ENST00000367338.3_Frame_Shift_Del_p.E140fs	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	140					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTAACCTGTTCCAGAATCACG	0.582													81	262	---	---	---	---					
MIA3	375056	broad.mit.edu	37	1	222837351	222837352	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:222837351_222837352insC	ENST00000344922.5	+	27	5299_5300	c.5274_5275insC	c.(5272-5277)gccaaafs	p.K1759fs	MIA3_ENST00000340535.7_Frame_Shift_Ins_p.K637fs|MIA3_ENST00000344441.6_Frame_Shift_Ins_p.K1759fs|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1759	Pro-rich.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		TTAATATGGCTCCAAAAGGGCC	0.485													7	379	---	---	---	---					
GALNT2	2590	broad.mit.edu	37	1	230379072	230379073	+	Frame_Shift_Ins	INS	-	-	G	rs139591495		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:230379072_230379073insG	ENST00000366672.4	+	7	700_701	c.628_629insG	c.(628-630)gggfs	p.G210fs	GALNT2_ENST00000543760.1_Frame_Shift_Ins_p.G172fs|GALNT2_ENST00000541865.1_Frame_Shift_Ins_p.G120fs	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	210	Catalytic subdomain A.			R -> W (in Ref. 1; AA sequence).	immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				CTCACGGGTTCGGGGGGCCGAT	0.644													10	155	---	---	---	---					
SIPA1L2	57568	broad.mit.edu	37	1	232650637	232650638	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:232650637_232650638insG	ENST00000366630.1	-	2	806_807	c.448_449insC	c.(448-450)aagfs	p.K150fs	SIPA1L2_ENST00000262861.4_Frame_Shift_Ins_p.K150fs			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	150					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				AAGTCCTCTTTGGGGGGAATGG	0.490													10	511	---	---	---	---					
RYR2	6262	broad.mit.edu	37	1	237993907	237993907	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:237993907delG	ENST00000366574.2	+	103	15050	c.14733delG	c.(14731-14733)cafs	p.Q4911fs	RYR2_ENST00000542537.1_Frame_Shift_Del_p.Q4895fs|RYR2_ENST00000360064.6_Frame_Shift_Del_p.Q4917fs|RYR2_ENST00000462585.1_3'UTR	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4911					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACACTTTACAGGAGCACAACT	0.458													420	481	---	---	---	---					
OR2M4	26245	broad.mit.edu	37	1	248402399	248402400	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr1:248402399_248402400insC	ENST00000306687.1	+	1	169_170	c.169_170insC	c.(169-171)cccfs	p.P57fs		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T57N(1)		NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ACAGCTCCACACCCCCATGTAC	0.470													7	629	---	---	---	---					
AC092159.2	0	broad.mit.edu	37	2	677761	677761	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:677761delG	ENST00000445418.1	+	0	288																											TGCAGGAGCCGGGGACATTGC	0.637													2	4	---	---	---	---					
LOC400940	400940	broad.mit.edu	37	2	6124553	6124553	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:6124553delC	ENST00000431188.1	+	0	2857																											tctgggtgttccttcccatgt	0.453													3	5	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14449411	14449411	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:14449411delA	ENST00000418420.1	-	0	251					NR_103814.1																						TCTTTCTAACAAAGCAAGTCT	0.393													7	2	---	---	---	---					
LINC00276	100499171	broad.mit.edu	37	2	14518374	14518374	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:14518374delA	ENST00000418420.1	-	0	116					NR_103814.1																						caagcatgcgaaaaaaaaaaa	0.358													4	2	---	---	---	---					
AC104623.2	0	broad.mit.edu	37	2	16705472	16705473	+	RNA	INS	-	-	GTGTGT	rs9306884	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:16705472_16705473insGTGTGT	ENST00000446357.1	+	0	314				AC104623.2_ENST00000443066.2_RNA																							tgtgtttgtgcgtgtgtgtgtg	0.505													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22189016	22189016	+	RNA	DEL	T	T	-	rs61289316		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:22189016delT	ENST00000450551.1	-	0	296																											ACAGTATTACTTTTTTTTTTT	0.378													3	6	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22477573	22477574	+	RNA	DEL	GT	GT	-	rs72132301		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:22477573_22477574delGT	ENST00000450551.1	-	0	70																											gtgtttgtgcgtgtgtgtgtgt	0.401													2	4	---	---	---	---					
AC068490.2	0	broad.mit.edu	37	2	22712509	22712510	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:22712509_22712510insA	ENST00000450551.1	-	0	70																											gggtgaagatcaaaaaactgcc	0.391													2	4	---	---	---	---					
LINC01317	104355287	broad.mit.edu	37	2	34232882	34232884	+	RNA	DEL	TCT	TCT	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:34232882_34232884delTCT	ENST00000366209.2	+	0	389																											tataaaatgatcttcttcattcc	0.300													7	1	---	---	---	---					
AC073218.1	0	broad.mit.edu	37	2	34660164	34660165	+	RNA	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:34660164_34660165insG	ENST00000422558.1	+	0	475																											aggttggaggtggggggcagct	0.500													2	4	---	---	---	---					
AC012593.1	0	broad.mit.edu	37	2	35113401	35113401	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:35113401delC	ENST00000588944.1	+	0	115																											tcccctagagccccaaaattc	0.483													2	4	---	---	---	---					
AC012593.1	0	broad.mit.edu	37	2	35234255	35234256	+	RNA	DEL	AC	AC	-	rs10589149		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:35234255_35234256delAC	ENST00000588944.1	+	0	115																											acacacacagacacacacacac	0.317													3	4	---	---	---	---					
AC009229.5	0	broad.mit.edu	37	2	38463226	38463226	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:38463226delC	ENST00000450854.1	-	0	533																											CTAATACTTTCCCTAACTTCC	0.398													5	1	---	---	---	---					
LOC101927043	101927043	broad.mit.edu	37	2	47500819	47500820	+	RNA	INS	-	-	CA	rs113686320	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:47500819_47500820insCA	ENST00000419035.1	-	0	66																		p.0?(2)|p.?(1)									ggtcacttcccgacacccccat	0.564													4	3	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	51468054	51468055	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:51468054_51468055insC	ENST00000440698.1	+	0	514																											CCTTTCACATGCCCCCTTTTAT	0.337													2	4	---	---	---	---					
LOC730100	730100	broad.mit.edu	37	2	52618834	52618835	+	RNA	DEL	GA	GA	-	rs2727883	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:52618834_52618835delGA	ENST00000440698.1	+	0	2999																											gtgtgtgtgtgagtgtgtgtgt	0.391													4	2	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	59122347	59122348	+	RNA	DEL	TG	TG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:59122347_59122348delTG	ENST00000452840.1	+	0	434																											TTTGTTTCTTTGTGTGTGTGTG	0.411													4	6	---	---	---	---					
RP11-444A22.1	0	broad.mit.edu	37	2	60014480	60014480	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:60014480delG	ENST00000606382.1	-	0	236																											ATTTCACAAAGTTTGGGTGTG	0.403													3	6	---	---	---	---					
LOC101927533	101927533	broad.mit.edu	37	2	65750023	65750023	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:65750023delA	ENST00000377977.3	+	0	862																											catctcaattaaaaaaaaaaa	0.403													2	4	---	---	---	---					
LOC100507073	100507073	broad.mit.edu	37	2	66813432	66813433	+	RNA	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:66813432_66813433insG	ENST00000433396.1	+	0	136																											TGGAAAGGTTTGGGGGGCGGAG	0.426													2	4	---	---	---	---					
LOC100133985	100133985	broad.mit.edu	37	2	70352090	70352090	+	RNA	DEL	A	A	-	rs55636455		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:70352090delA	ENST00000414141.1	-	0	272					NR_024444.1																						acgccgtctcaaaaaaaaaaa	0.512													5	4	---	---	---	---					
AC104135.2	0	broad.mit.edu	37	2	75151240	75151240	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:75151240delG	ENST00000418001.1	-	0	31																											gataatgttaggaatttgtgt	0.289													2	4	---	---	---	---					
AC084193.1	0	broad.mit.edu	37	2	80957974	80957975	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:80957974_80957975insA	ENST00000450290.1	-	0	468																											tgcctatatttaaaaaaaaagc	0.297													2	4	---	---	---	---					
AC084193.1	0	broad.mit.edu	37	2	81053803	81053803	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:81053803delA	ENST00000450290.1	-	0	146																											AAGGAAGTTTAAGAGCTAAAT	0.443													3	6	---	---	---	---					
IGKV1OR2-118	339562	broad.mit.edu	37	2	90458648	90458648	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:90458648delT	ENST00000603238.1	+	2	324	c.324delT	c.(322-324)tgfs	p.108fs																								CTTATTACTGTCAACAGAGTG	0.512													8	684	---	---	---	---					
LOC101927070	101927070	broad.mit.edu	37	2	99386282	99386282	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:99386282delG	ENST00000419865.2	-	0	462																											ATGAAGAACAGGTACAGGGTG	0.403													2	4	---	---	---	---					
AC073987.1	0	broad.mit.edu	37	2	103749213	103749213	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:103749213delG	ENST00000422683.1	-	0	213																											ctcttcctgtgtgaacctgag	0.522													4	4	---	---	---	---					
AC096669.3	0	broad.mit.edu	37	2	108170349	108170350	+	RNA	DEL	AC	AC	-	rs66946831		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:108170349_108170350delAC	ENST00000443205.1	+	0	345																											AATTAGGcatacacacacacac	0.356													2	4	---	---	---	---					
LOC100506797	100506797	broad.mit.edu	37	2	118927577	118927577	+	RNA	DEL	T	T	-	rs72093234		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:118927577delT	ENST00000414886.1	-	0	533																											ATTTTTGATGTTTTTTttttt	0.428													5	6	---	---	---	---					
AC012363.13	0	broad.mit.edu	37	2	121080887	121080887	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:121080887delC	ENST00000437837.1	+	0	132																											GCTGCTGCCTCCCCCCTCCTC	0.537													13	1	---	---	---	---					
AC062021.1	0	broad.mit.edu	37	2	140134871	140134872	+	RNA	INS	-	-	CT	rs139350630	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:140134871_140134872insCT	ENST00000429008.1	+	0	319																											ATATCTACTAACTGCtatatta	0.431													7	3	---	---	---	---					
TEX41	401014	broad.mit.edu	37	2	145441290	145441290	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:145441290delC	ENST00000445791.1	+	0	124					NR_033870.2																						ATTACTGTGTCCCAGCAAACA	0.368													3	3	---	---	---	---					
TEX41	401014	broad.mit.edu	37	2	145479619	145479620	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:145479619_145479620insT	ENST00000445791.1	+	0	124					NR_033870.2																						agaactctccaccccaaatcaa	0.376													4	4	---	---	---	---					
LOC101929231	101929231	broad.mit.edu	37	2	150619977	150619978	+	RNA	INS	-	-	T	rs71397037	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:150619977_150619978insT	ENST00000449714.1	+	0	697																											catcaaagtgatttttttaccg	0.351													2	4	---	---	---	---					
AC092684.1	0	broad.mit.edu	37	2	164650312	164650313	+	RNA	DEL	GG	GG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:164650312_164650313delGG	ENST00000429636.1	-	0	379																											aggctgAAGAGGGAGTGAGAAG	0.460													8	13	---	---	---	---					
AC079305.11	0	broad.mit.edu	37	2	177997830	177997830	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:177997830delT	ENST00000441205.1	-	0	169																											cactgaaaacttttttttttt	0.378													3	3	---	---	---	---					
LOC101927156	101927156	broad.mit.edu	37	2	182128629	182128632	+	RNA	DEL	TGTG	TGTG	-	rs71846147		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:182128629_182128632delTGTG	ENST00000435411.1	+	0	358																											Agtgtgtgtctgtgtgtgtgtgtg	0.353													3	3	---	---	---	---					
LOC101927156	101927156	broad.mit.edu	37	2	182207783	182207783	+	RNA	DEL	T	T	-	rs58326825		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:182207783delT	ENST00000435411.1	+	0	358																											TGTACCCTTATCCTCTTCCCT	0.368													4	4	---	---	---	---					
COL5A2	1290	broad.mit.edu	37	2	189943835	189943836	+	Splice_Site	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:189943835_189943836insA	ENST00000374866.3	-	15	1235		c.e15-2			NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AGCTTCACCCTAAAAAAAAATG	0.381													7	185	---	---	---	---					
AC093388.3	0	broad.mit.edu	37	2	191409972	191409972	+	RNA	DEL	A	A	-	rs112374601		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:191409972delA	ENST00000457407.1	+	0	374																											CGATCTCACCAACTCCACTTC	0.368													4	4	---	---	---	---					
PCGEM1	64002	broad.mit.edu	37	2	193628315	193628315	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:193628315delC	ENST00000454040.1	+	0	268					NR_002769.1																						gaagttcactccccaagggag	0.473													4	5	---	---	---	---					
LOC101927431	101927431	broad.mit.edu	37	2	195618890	195618891	+	RNA	INS	-	-	GT	rs71012444	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:195618890_195618891insGT	ENST00000447194.1	+	0	586																											TTGTTAGAGAAgtgtgtgtgtg	0.351													3	5	---	---	---	---					
AC016903.2	0	broad.mit.edu	37	2	205360899	205360899	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:205360899delT	ENST00000456384.1	+	0	268																											TTCTTTGCCCTTCTACAAATA	0.299													2	4	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208196318	208196319	+	RNA	INS	-	-	A	rs11411713	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:208196318_208196319insA	ENST00000418850.1	-	0	455				AC007879.5_ENST00000412387.1_RNA																							GAATGGTAGAGAAAAAAAAAGT	0.322													7	4	---	---	---	---					
AC007879.5	0	broad.mit.edu	37	2	208219223	208219224	+	RNA	INS	-	-	A	rs34267327	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:208219223_208219224insA	ENST00000418850.1	-	0	400				AC007879.5_ENST00000412387.1_RNA																							CAACATTTGAGAAAAAAAAAAT	0.317													4	4	---	---	---	---					
PTH2R	5746	broad.mit.edu	37	2	209367957	209367959	+	RNA	DEL	TTC	TTC	-	rs71395505		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:209367957_209367959delTTC	ENST00000424628.1	+	0	103																											tccagctttgttcttctccctca	0.315													3	6	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217624038	217624038	+	RNA	DEL	T	T	-	rs77791202		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:217624038delT	ENST00000447289.1	+	0	388																											TCtttctttcttttttttttt	0.458													4	3	---	---	---	---					
AC007563.5	0	broad.mit.edu	37	2	217748633	217748633	+	RNA	DEL	G	G	-	rs111929071		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:217748633delG	ENST00000447289.1	+	0	510				AC007563.5_ENST00000607591.1_RNA																							GGCTGTCAGAGGGGACGTTCA	0.562													3	5	---	---	---	---					
TNS1	7145	broad.mit.edu	37	2	218855136	218855136	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:218855136delC	ENST00000450996.1	+	0	355																											cagccacacaccctgaccaca	0.572													6	5	---	---	---	---					
AC114765.1	0	broad.mit.edu	37	2	221306593	221306594	+	RNA	INS	-	-	TG	rs61697929	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:221306593_221306594insTG	ENST00000432993.1	+	0	427																											GTGACTTTCTTtgtgtgtgtgt	0.436													4	8	---	---	---	---					
PAX3	5077	broad.mit.edu	37	2	223086019	223086020	+	Frame_Shift_Ins	INS	-	-	C	rs45522331	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:223086019_223086020insC	ENST00000350526.4	-	6	1015_1016	c.879_880insG	c.(877-882)ggtcccfs	p.P294fs	PAX3_ENST00000464706.1_5'UTR|PAX3_ENST00000344493.4_Frame_Shift_Ins_p.P294fs|PAX3_ENST00000392070.2_Frame_Shift_Ins_p.P294fs|PAX3_ENST00000336840.6_Frame_Shift_Ins_p.P294fs|PAX3_ENST00000409551.3_Frame_Shift_Ins_p.P293fs|PAX3_ENST00000392069.2_Frame_Shift_Ins_p.P294fs	NM_181457.3	NP_852122.1	P23760	PAX3_HUMAN	paired box 3	294					apoptosis|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX3/NCOA2(4)|PAX3/NCOA1(8)|PAX3/FOXO1(749)	NS(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(13)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	38		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;1.85e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GTGGGAGGGAACCCCCCGGGAA	0.540			T	"""FOXO1A, NCOA1"""	alveolar rhabdomyosarcoma		Waardenburg syndrome; craniofacial-deafness-hand syndrome						7	472	---	---	---	---					
AC010149.4	0	broad.mit.edu	37	2	231436150	231436150	+	RNA	DEL	C	C	-	rs59237846		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:231436150delC	ENST00000455357.1	-	0	361				AC010149.4_ENST00000414539.1_RNA																							ctaaagcagaccttctgcctg	0.547													6	8	---	---	---	---					
EIF4E2	9470	broad.mit.edu	37	2	233431933	233431934	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:233431933_233431934insG	ENST00000409167.3	+	5	575_576	c.539_540insG	c.(538-540)tggfs	p.W180fs	EIF4E2_ENST00000409495.1_Frame_Shift_Ins_p.W225fs|EIF4E2_ENST00000409098.1_Intron|EIF4E2_ENST00000409514.1_Intron|EIF4E2_ENST00000409394.1_Intron|EIF4E2_ENST00000409322.1_Intron|EIF4E2_ENST00000258416.3_Intron			O60573	IF4E2_HUMAN	eukaryotic translation initiation factor 4E family member 2	0					regulation of translation	cytoplasm|mRNA cap binding complex	RNA cap binding|translation initiation factor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	8		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;2.3e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000912)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AAGTACGTGTTGGGGGGTTATG	0.515													7	630	---	---	---	---					
DGKD	8527	broad.mit.edu	37	2	234357832	234357833	+	Frame_Shift_Ins	INS	-	-	C	rs138076232		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:234357832_234357833insC	ENST00000264057.2	+	15	1710_1711	c.1698_1699insC	c.(1696-1701)ccccccfs	p.PP566fs	DGKD_ENST00000409813.3_Frame_Shift_Ins_p.PP522fs	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	566					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	TGCCCAACCCGCCCCCCACCAT	0.614													10	422	---	---	---	---					
AC097713.3	0	broad.mit.edu	37	2	235367664	235367665	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:235367664_235367665insT	ENST00000418025.1	+	0	188																											ttattttaaaatttgttaagtc	0.312													5	4	---	---	---	---					
AC113618.1	0	broad.mit.edu	37	2	239629498	239629499	+	RNA	INS	-	-	T	rs141479736	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:239629498_239629499insT	ENST00000448543.1	+	0	98																											TTTGGAGACCCGTCTCCATTCT	0.510													3	3	---	---	---	---					
LINC01237	101927289	broad.mit.edu	37	2	242993376	242993377	+	RNA	DEL	GA	GA	-	rs61015023		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:242993376_242993377delGA	ENST00000415434.1	+	0	310				AC093642.6_ENST00000446593.1_lincRNA																							aCATTGACACgagagagagaga	0.361													3	5	---	---	---	---					
LINC01237	101927289	broad.mit.edu	37	2	243010013	243010014	+	RNA	INS	-	-	A	rs145494722	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr2:243010013_243010014insA	ENST00000415434.1	+	0	310				AC093642.6_ENST00000446593.1_lincRNA																							TTTTTTTTTCCAAAAAAAAGTT	0.312													4	2	---	---	---	---					
LINC01266	101927215	broad.mit.edu	37	3	656915	656915	+	RNA	DEL	T	T	-	rs11336773		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:656915delT	ENST00000420823.1	+	0	176																											TCCAGGTTTCTGCTTAAGCAC	0.299													4	6	---	---	---	---					
LINC01266	101927215	broad.mit.edu	37	3	759456	759456	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:759456delA	ENST00000420823.1	+	0	176																											CTTCACCTCTAAAAAAAAACA	0.333													2	4	---	---	---	---					
LINC01266	101927215	broad.mit.edu	37	3	815443	815443	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:815443delT	ENST00000420823.1	+	0	212																											AAAGTAGTACTTTAGGTGGGT	0.328													3	3	---	---	---	---					
AC026167.1	0	broad.mit.edu	37	3	6350032	6350033	+	RNA	INS	-	-	AA			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:6350032_6350033insAA	ENST00000435651.1	+	0	95																											cacacacacacacacacacaaa	0.356													6	6	---	---	---	---					
GRM7-AS3	101927347	broad.mit.edu	37	3	6716952	6716952	+	RNA	DEL	C	C	-	rs181012	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:6716952delC	ENST00000433639.1	+	0	194																											aaaaaaaaaaCAACTTTagta	0.353													3	4	---	---	---	---					
EMC3-AS1	442075	broad.mit.edu	37	3	10035779	10035783	+	RNA	DEL	AGTCT	AGTCT	-	rs35714562		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:10035779_10035783delAGTCT	ENST00000326237.3	+	0	354																											GGGGAAGAGAAGTCTGATCTGACAT	0.380													9	48	---	---	---	---					
SYN2	6854	broad.mit.edu	37	3	12098824	12098825	+	RNA	DEL	TA	TA	-	rs71672266	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:12098824_12098825delTA	ENST00000432424.2	+	0	549							Q86VA8	Q86VA8_HUMAN	synapsin II						neurotransmitter secretion	synaptic vesicle	ATP binding|ligase activity			breast(5)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	18						tgtgtgtgtgtATACTTTTTGA	0.406													4	9	---	---	---	---					
LINC00620	285375	broad.mit.edu	37	3	13723620	13723625	+	RNA	DEL	TGTGCG	TGTGCG	-	rs6770634		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:13723620_13723625delTGTGCG	ENST00000419618.1	+	0	113				LINC00620_ENST00000438915.1_RNA	NR_027103.1																						tgcatgtgtatgtgcgtgtgcgtgtg	0.563													6	5	---	---	---	---					
HMGB1P5	10354	broad.mit.edu	37	3	22424406	22424406	+	RNA	DEL	A	A	-	rs35347330		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:22424406delA	ENST00000451497.1	+	0	971																											tttttttattaaaaaaaaaaa	0.353													3	3	---	---	---	---					
ZNF197-AS1	100874094	broad.mit.edu	37	3	44661815	44661826	+	RNA	DEL	TGTATGTGTGTG	TGTATGTGTGTG	-	rs72278134		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:44661815_44661826delTGTATGTGTGTG	ENST00000447691.2	-	0	76				RP11-944L7.4_ENST00000457331.1_RNA																							tgtgtgtgcatgtatgtgtgtgtgtgtgtgtg	0.429													3	4	---	---	---	---					
LOC102724297	102724297	broad.mit.edu	37	3	46430605	46430611	+	RNA	DEL	GAGCTCT	GAGCTCT	-	rs78184588		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:46430605_46430611delGAGCTCT	ENST00000451485.1	-	0	391																											tgactgcgtagagctctgttgcaaaaa	0.391													5	2	---	---	---	---					
RP11-20B7.1	0	broad.mit.edu	37	3	73893549	73893549	+	RNA	DEL	T	T	-	rs11352586		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:73893549delT	ENST00000498832.1	+	0	68																											TAGATATATATTTTGTTTAAT	0.353													6	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82243757	82243757	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:82243757delA	ENST00000470263.1	+	0	346																											TTCAAAACTGAGGTAAGTAAA	0.299													2	4	---	---	---	---					
RP11-260O18.1	0	broad.mit.edu	37	3	82505585	82505586	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:82505585_82505586insC	ENST00000470263.1	+	0	994																											ctgcctcagcacccccaagtgg	0.554													2	4	---	---	---	---					
LINC00971	440970	broad.mit.edu	37	3	84741480	84741480	+	RNA	DEL	A	A	-	rs140144338		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:84741480delA	ENST00000484892.1	-	0	2354					NR_033860.1																						CCTGTCCCAGAAAAAAAAAAA	0.388													6	8	---	---	---	---					
RP11-789F5.1	0	broad.mit.edu	37	3	86315313	86315313	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:86315313delT	ENST00000479244.1	-	0	366																											TTCTTATTCATAGGTATTTAA	0.284													5	2	---	---	---	---					
CTD-2021J15.1	0	broad.mit.edu	37	3	98721407	98721407	+	RNA	DEL	G	G	-	rs35001780		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:98721407delG	ENST00000474798.1	+	0	196																											tgacaccccagtagggattct	0.582													3	5	---	---	---	---					
LINC00882	100302640	broad.mit.edu	37	3	106650722	106650724	+	RNA	DEL	CTC	CTC	-	rs35138153	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:106650722_106650724delCTC	ENST00000484698.1	-	0	337																											TTTGATGACTCTCATATTTGAGA	0.305													9	10	---	---	---	---					
LINC01205	401082	broad.mit.edu	37	3	109132294	109132294	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:109132294delT	ENST00000497996.1	+	0	218																											tcattcctaattttttttttt	0.502													2	4	---	---	---	---					
RP11-457K10.1	0	broad.mit.edu	37	3	109442162	109442163	+	RNA	INS	-	-	TG	rs138754811	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:109442162_109442163insTG	ENST00000485384.1	+	0	29																											GGCTATGAATTtgtgtgtgtgt	0.351													4	7	---	---	---	---					
RP11-180K7.1	0	broad.mit.edu	37	3	112523228	112523230	+	RNA	DEL	TCT	TCT	-	rs10574881		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:112523228_112523230delTCT	ENST00000496067.2	+	0	267																											Gtctccttcctcttcttcttctt	0.399													3	4	---	---	---	---					
RP11-572M11.4	0	broad.mit.edu	37	3	112842524	112842524	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:112842524delT	ENST00000496389.1	+	0	399																											gaggcctatattttagtgagg	0.373													2	4	---	---	---	---					
RP11-572M11.4	0	broad.mit.edu	37	3	112855415	112855415	+	RNA	DEL	T	T	-	rs112022684		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:112855415delT	ENST00000496389.1	+	0	399																											GTTAGACTTATTTGTGGTCAA	0.333													2	4	---	---	---	---					
LOC101929717	101929717	broad.mit.edu	37	3	112866436	112866436	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:112866436delG	ENST00000490139.1	-	0	516				RP11-572M11.4_ENST00000496389.1_RNA																							CTTTGCATTTGGCTGCTGTCT	0.433													17	2	---	---	---	---					
RP11-553L6.2	0	broad.mit.edu	37	3	113951881	113951881	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:113951881delG	ENST00000493033.1	+	0	160				RP11-553L6.2_ENST00000481773.1_RNA																							AGTCCCCCTTGGGTCAGGGGG	0.652													7	7	---	---	---	---					
RP11-190P13.2	0	broad.mit.edu	37	3	114998900	114998900	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:114998900delA	ENST00000459855.1	+	0	338																											TGCTAAATTTAAAAAAAAAAA	0.363													2	4	---	---	---	---					
RP11-384F7.1	0	broad.mit.edu	37	3	118133526	118133527	+	RNA	INS	-	-	AAAG	rs149542215	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:118133526_118133527insAAAG	ENST00000482142.1	-	0	232																											ttaatagagctaaagagagaga	0.366													4	3	---	---	---	---					
PLXNA1	5361	broad.mit.edu	37	3	126722193	126722193	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:126722193delC	ENST00000251772.4	+	3	1398	c.1329delC	c.(1327-1329)aafs	p.N443fs	PLXNA1_ENST00000393409.2_Frame_Shift_Del_p.N466fs			Q9UIW2	PLXA1_HUMAN	plexin A1	466	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		ACCTCTCAAACCCCGGTGGCC	0.672													8	12	---	---	---	---					
RP11-93K22.13	0	broad.mit.edu	37	3	129811873	129811877	+	RNA	DEL	AAAAA	AAAAA	-	rs71158104		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:129811873_129811877delAAAAA	ENST00000514010.1	-	0	157				ALG1L2_ENST00000507643.1_RNA																							agtctgtcagaaaaaaaaaaaaaaa	0.385													4	4	---	---	---	---					
LOC339874	339874	broad.mit.edu	37	3	131092721	131092722	+	RNA	INS	-	-	TT			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:131092721_131092722insTT	ENST00000502521.1	-	0	239					NR_038976.1																						AAAATGTCAGCttttttttttt	0.406													3	6	---	---	---	---					
NPHP3-AS1	348808	broad.mit.edu	37	3	132579748	132579749	+	RNA	DEL	TG	TG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:132579748_132579749delTG	ENST00000504440.1	+	0	1824					NR_002811.1																						ATAGTGAGCCtgtgtgtgtgtg	0.391													3	6	---	---	---	---					
RP11-649A16.1	0	broad.mit.edu	37	3	146988490	146988490	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:146988490delA	ENST00000473299.1	-	0	132																											ccagagagtgaagactacaat	0.393													9	5	---	---	---	---					
RP11-501O2.1	0	broad.mit.edu	37	3	147838287	147838288	+	RNA	INS	-	-	A	rs149965490	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:147838287_147838288insA	ENST00000476987.1	+	0	226																											tatgatagcggaaaaaaaaact	0.248													2	4	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153277242	153277242	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:153277242delC	ENST00000493214.2	-	0	260																											aaacttcaggccaatattcct	0.398													4	7	---	---	---	---					
RP11-23D24.2	0	broad.mit.edu	37	3	153420562	153420563	+	RNA	DEL	TC	TC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:153420562_153420563delTC	ENST00000493214.2	-	0	77																											ttcatttctgtctctctctctc	0.421													4	3	---	---	---	---					
ARHGEF26-AS1	100507524	broad.mit.edu	37	3	153779709	153779710	+	RNA	DEL	AC	AC	-	rs35207629		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:153779709_153779710delAC	ENST00000491862.1	-	0	256				ARHGEF26-AS1_ENST00000479270.1_RNA|ARHGEF26-AS1_ENST00000467912.1_RNA|ARHGEF26-AS1_ENST00000480639.1_RNA	NR_037901.1																						TCTTTCCTAGacacacacacac	0.446													4	8	---	---	---	---					
RP11-290K4.2	0	broad.mit.edu	37	3	157751021	157751022	+	RNA	INS	-	-	AAGG			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:157751021_157751022insAAGG	ENST00000488999.1	-	0	488																											aggaggagggaaaggaaggaag	0.450													3	4	---	---	---	---					
IL12A-AS1	101928376	broad.mit.edu	37	3	159661982	159661983	+	RNA	INS	-	-	T	rs71628416		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:159661982_159661983insT	ENST00000497452.1	-	0	1350																											gacaattgcaattttttttttt	0.455													6	2	---	---	---	---					
IL12A-AS1	101928376	broad.mit.edu	37	3	159846716	159846716	+	RNA	DEL	T	T	-	rs78699964		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:159846716delT	ENST00000497452.1	-	0	517																											gtccttggacttttttttttt	0.438													2	4	---	---	---	---					
LINC01192	647107	broad.mit.edu	37	3	162888379	162888379	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:162888379delG	ENST00000490357.1	+	0	103																											aattgtgagtgggagttcatt	0.378													3	3	---	---	---	---					
LINC01322	103695433	broad.mit.edu	37	3	165290843	165290843	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:165290843delG	ENST00000496693.1	+	0	312																											cagcctaactgggagacaccc	0.582													2	4	---	---	---	---					
RP11-324C10.1	0	broad.mit.edu	37	3	172920343	172920343	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:172920343delG	ENST00000447709.1	+	0	22																											gagagagtgaggggggagatg	0.463													6	7	---	---	---	---					
LOC285389	285389	broad.mit.edu	37	3	193777791	193777792	+	RNA	INS	-	-	C	rs150811974	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:193777791_193777792insC	ENST00000432154.1	-	0	214																											AGTATTAATCACCCCTTTCCTG	0.426													5	5	---	---	---	---					
LOC100507391	100507391	broad.mit.edu	37	3	194477357	194477357	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr3:194477357delG	ENST00000423318.1	+	0	940					NR_037891.1																						TTGGCGATTTGGGGCCCCACA	0.532													19	37	---	---	---	---					
LINC01182	101929071	broad.mit.edu	37	4	13770865	13770878	+	RNA	DEL	AAGTTTAACATCAA	AAGTTTAACATCAA	-	rs144397924		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:13770865_13770878delAAGTTTAACATCAA	ENST00000510907.1	+	0	281																											ctaaatatggaagtttaacatcaaaagaacccat	0.416													4	4	---	---	---	---					
LINC00504	201853	broad.mit.edu	37	4	14509098	14509098	+	RNA	DEL	T	T	-	rs113284877		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:14509098delT	ENST00000505089.1	-	0	461																											ttagataaggttttttttttt	0.383													2	4	---	---	---	---					
LINC00504	201853	broad.mit.edu	37	4	14887585	14887586	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:14887585_14887586insA	ENST00000505089.1	-	0	111																											GTTCTTTGCAGAAAAAAGAGAT	0.421													2	4	---	---	---	---					
LOC101929095	101929095	broad.mit.edu	37	4	15338669	15338674	+	RNA	DEL	CACACA	CACACA	-	rs58511826		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:15338669_15338674delCACACA	ENST00000502344.1	-	0	86																											ctctctctctcacacacacacacaca	0.442													3	3	---	---	---	---					
RP11-608O21.1	0	broad.mit.edu	37	4	19477453	19477454	+	RNA	INS	-	-	TT			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:19477453_19477454insTT	ENST00000511431.1	+	0	217																											tacctggtgtgtttgaaaaaca	0.465													4	6	---	---	---	---					
GBA3	57733	broad.mit.edu	37	4	22699054	22699055	+	RNA	DEL	TG	TG	-	rs73108302	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:22699054_22699055delTG	ENST00000508166.1	+	0	160				GBA3_ENST00000503442.1_RNA	NM_020973.4	NP_066024.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TTAAGACATTtgtgtgtgtgtg	0.381													7	8	---	---	---	---					
LGI2	55203	broad.mit.edu	37	4	25005320	25005321	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:25005320_25005321insC	ENST00000382114.4	-	8	1575_1576	c.1390_1391insG	c.(1390-1392)catfs	p.H464fs		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	464						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				CAGGGTCATGGCCCCCCGGGAT	0.515													8	412	---	---	---	---					
SEL1L3	23231	broad.mit.edu	37	4	25849101	25849101	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:25849101delC	ENST00000399878.3	-	2	670	c.548delG	c.(547-549)gcfs	p.G183fs	SEL1L3_ENST00000513364.1_Intron|SEL1L3_ENST00000502949.1_Frame_Shift_Del_p.G30fs|SEL1L3_ENST00000264868.5_Frame_Shift_Del_p.G148fs	NM_015187.3	NP_056002.2	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3 (C. elegans)	183						integral to membrane	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|urinary_tract(2)	14						CCAGTCTCTGCCACTGTATTT	0.428													17	112	---	---	---	---					
LOC101928622	101928622	broad.mit.edu	37	4	33921554	33921554	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:33921554delG	ENST00000505018.1	-	0	423				RP11-79E3.2_ENST00000506650.1_lincRNA																							aggaggaagaggaggaaaact	0.393													2	4	---	---	---	---					
RP11-548L20.1	0	broad.mit.edu	37	4	34270379	34270379	+	RNA	DEL	A	A	-	rs7682783		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:34270379delA	ENST00000514877.1	-	0	125																											cgtcccccccaaaaaaaaaga	0.428													4	8	---	---	---	---					
UCHL1-AS1	101410542	broad.mit.edu	37	4	41242147	41242147	+	RNA	DEL	A	A	-	rs71810395		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:41242147delA	ENST00000507190.1	-	0	169					NR_102709.1																						AGACACTGGCAAGTTTTCAAG	0.458													4	4	---	---	---	---					
RP11-395F4.1	0	broad.mit.edu	37	4	43166458	43166458	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:43166458delA	ENST00000505575.1	+	0	120																											ACTTAGACAGATGCAGGTTCT	0.338													3	4	---	---	---	---					
LINC01088	100505875	broad.mit.edu	37	4	80010695	80010697	+	RNA	DEL	CTA	CTA	-	rs79726265		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:80010695_80010697delCTA	ENST00000509088.1	+	0	349				RP11-438E5.1_ENST00000513153.1_RNA|RP11-438E5.1_ENST00000510667.1_RNA	NR_038342.1																						GCAAAGAGTTCTACTGCAAATAG	0.458													6	0	---	---	---	---					
RASGEF1B	153020	broad.mit.edu	37	4	82843682	82843682	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:82843682delG	ENST00000510780.1	-	0	244																											CACCGAAGCTGGGAAGCTCCT	0.423													2	4	---	---	---	---					
CYP2U1	113612	broad.mit.edu	37	4	108868577	108868579	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:108868577_108868579delCTC	ENST00000332884.6	+	3	1447_1449	c.1172_1174delCTC	c.(1171-1176)gct>g	p.AP391del	RP11-286E11.1_ENST00000513071.1_RNA|CYP2U1_ENST00000508453.1_In_Frame_Del_p.AP182del	NM_183075.2	NP_898898.1	Q7Z449	CP2U1_HUMAN	cytochrome P450, family 2, subfamily U, polypeptide 1	391					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|large_intestine(2)|lung(4)|skin(2)|urinary_tract(1)	10		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000128)		GCCAACCGAGCTCCTTCCCTCAC	0.478													7	78	---	---	---	---					
LOC729218	729218	broad.mit.edu	37	4	119551305	119551306	+	RNA	INS	-	-	TC			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:119551305_119551306insTC	ENST00000567913.2	+	0	1047																											gagctccaccttctcagatcag	0.510													3	4	---	---	---	---					
RP11-125O18.1	0	broad.mit.edu	37	4	128018839	128018840	+	RNA	INS	-	-	GT	rs4000742	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:128018839_128018840insGT	ENST00000504050.1	-	0	483																											AATGCGTGCACgtgtgtgtgtg	0.391													2	4	---	---	---	---					
RP11-125O18.1	0	broad.mit.edu	37	4	128323486	128323493	+	RNA	DEL	TGGATGGA	TGGATGGA	-	rs33965706		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:128323486_128323493delTGGATGGA	ENST00000504050.1	-	0	333																											TATCTTTAACtggatggatggatggatg	0.418													3	3	---	---	---	---					
RP11-138I17.1	0	broad.mit.edu	37	4	137795302	137795303	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:137795302_137795303insT	ENST00000505736.1	-	0	155																											AAAGGAGTCCATTTTTAGGCAG	0.282													2	4	---	---	---	---					
LINC00499	100874047	broad.mit.edu	37	4	139245197	139245198	+	RNA	DEL	TG	TG	-	rs36113613		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:139245197_139245198delTG	ENST00000510736.1	+	0	106																											tgattaaaaCTGTGATGAAAAA	0.302													8	0	---	---	---	---					
LINC00499	100874047	broad.mit.edu	37	4	139338222	139338223	+	RNA	DEL	CA	CA	-	rs10554033		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:139338222_139338223delCA	ENST00000510736.1	+	0	485																											CCTGCTCCACCACAATGCCCTC	0.431													5	1	---	---	---	---					
RP11-371F15.3	0	broad.mit.edu	37	4	139878018	139878019	+	RNA	INS	-	-	A	rs143258161	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:139878018_139878019insA	ENST00000511951.1	-	0	161																											AGAGTGAAAAGAAAAAaaaaat	0.371													4	2	---	---	---	---					
RP11-364L4.3	0	broad.mit.edu	37	4	144235152	144235153	+	RNA	INS	-	-	A	rs11299223		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:144235152_144235153insA	ENST00000512715.1	+	0	44																											AAGGAAGCAAGAAAAAAAAAAA	0.401													2	4	---	---	---	---					
RP11-285C1.2	0	broad.mit.edu	37	4	153966684	153966684	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:153966684delC	ENST00000515232.1	+	0	218																											TCATCCCCTGCCCCCAAGTTC	0.458													5	4	---	---	---	---					
LOC102724776	102724776	broad.mit.edu	37	4	156239486	156239487	+	RNA	INS	-	-	T	rs70954026		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:156239486_156239487insT	ENST00000593387.1	+	0	155				AC097467.2_ENST00000601977.1_RNA|AC097467.2_ENST00000602249.1_RNA|AC097467.2_ENST00000598252.1_RNA|AC097467.2_ENST00000597939.1_RNA|AC097467.2_ENST00000597955.1_RNA|AC097467.2_ENST00000595229.1_RNA|AC097467.2_ENST00000593486.1_RNA|AC097467.2_ENST00000512269.1_RNA|AC097467.2_ENST00000508191.1_RNA|AC097467.2_ENST00000595760.1_RNA																							ttctttctttcttttttttttt	0.421													3	3	---	---	---	---					
DDX60L	91351	broad.mit.edu	37	4	169296600	169296600	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:169296600delC	ENST00000511577.1	-	34	4808	c.4561delG	c.(4561-4563)ccfs	p.A1521fs	DDX60L_ENST00000260184.7_Frame_Shift_Del_p.A1521fs			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	1521							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		AGGAAGGAGGCAAAATCCTTC	0.418													23	18	---	---	---	---					
LINC00290	728081	broad.mit.edu	37	4	182077460	182077461	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:182077460_182077461insC	ENST00000512487.1	-	0	74					NR_033918.1																						AGTAATATTTTCCAATACGTTG	0.257													2	4	---	---	---	---					
LOC728339	728339	broad.mit.edu	37	4	190835547	190835547	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr4:190835547delT	ENST00000511785.1	-	0	231																											cataaagatgttctagtccct	0.368													4	9	---	---	---	---					
CTD-2297D10.2	101929176	broad.mit.edu	37	5	5136718	5136718	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:5136718delT	ENST00000512155.1	-	0	99																											CACTCGTGTGTTTTGCATCTC	0.547													2	4	---	---	---	---					
RP11-122F24.1	0	broad.mit.edu	37	5	6991703	6991704	+	RNA	DEL	TC	TC	-	rs70937128		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:6991703_6991704delTC	ENST00000512838.1	+	0	69																											tctctgtctgtctgtgtgtgtg	0.376													4	8	---	---	---	---					
RP11-122F24.1	0	broad.mit.edu	37	5	7064928	7064929	+	RNA	INS	-	-	T	rs68164298		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:7064928_7064929insT	ENST00000512838.1	+	0	154																											CAAAACTGGAAttttttttttt	0.411													3	6	---	---	---	---					
LOC729506	729506	broad.mit.edu	37	5	8337559	8337559	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:8337559delG	ENST00000501071.1	-	0	351					NR_039984.1																						CCTGCACTGTGGAAAGGCCAT	0.448													5	6	---	---	---	---					
LOC729506	729506	broad.mit.edu	37	5	8411350	8411350	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:8411350delA	ENST00000501071.1	-	0	168				RP11-480D4.2_ENST00000512406.1_lincRNA	NR_039984.1																						ATCAAAAGTGAAAAAAAAAAC	0.353													4	4	---	---	---	---					
LOC729506	729506	broad.mit.edu	37	5	8419225	8419226	+	RNA	DEL	GG	GG	-	rs10537784	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:8419225_8419226delGG	ENST00000501071.1	-	0	168				RP11-480D4.2_ENST00000512406.1_lincRNA	NR_039984.1																						aagaaactgtggGGGgtgtgtg	0.411													2	4	---	---	---	---					
CTD-2215L10.1	0	broad.mit.edu	37	5	9010637	9010637	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:9010637delG	ENST00000506519.1	+	0	121																											ATGGAAGAATGGCATCACGTA	0.438													10	8	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9659355	9659355	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:9659355delC	ENST00000511616.1	-	0	1586					NR_027112.2																						ATGAACTACTCCCCCATGGGA	0.498													6	8	---	---	---	---					
LOC285692	285692	broad.mit.edu	37	5	9767784	9767784	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:9767784delG	ENST00000511616.1	-	0	521					NR_027112.2																						tctcacgcctgtactctcagc	0.547													7	12	---	---	---	---					
RP11-419C19.2	0	broad.mit.edu	37	5	12935208	12935208	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:12935208delC	ENST00000510065.1	-	0	166																											cagctccctgccccccatcca	0.532													7	4	---	---	---	---					
LOC101929454	101929454	broad.mit.edu	37	5	15203784	15203784	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:15203784delG	ENST00000511443.1	-	0	247																											ATAAACCCTAGGGACAATGGA	0.423													6	3	---	---	---	---					
LOC646241	646241	broad.mit.edu	37	5	17898931	17898931	+	RNA	DEL	A	A	-	rs58399633		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:17898931delA	ENST00000514771.1	+	0	283																											AGGGGCTAAGAAAAAAAAAAA	0.343													3	5	---	---	---	---					
RP11-774D14.1	0	broad.mit.edu	37	5	20924663	20924664	+	RNA	DEL	TT	TT	-	rs70957008		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:20924663_20924664delTT	ENST00000502427.1	+	0	541																											TATAGGTCACtttttttttttt	0.431													5	1	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21534245	21534246	+	RNA	INS	-	-	TG	rs143137704		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:21534245_21534246insTG	ENST00000607545.1	+	0	314					NR_027026.1																						GCAGGTGTGTCTGTCACAAACA	0.520													9	18	---	---	---	---					
GUSBP1	728411	broad.mit.edu	37	5	21553290	21553291	+	RNA	INS	-	-	C	rs146167836		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:21553290_21553291insC	ENST00000607545.1	+	0	314					NR_027026.1																						gattttattttcccccattgaa	0.337													3	6	---	---	---	---					
RP11-804N13.1	0	broad.mit.edu	37	5	21692977	21692978	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:21692977_21692978insT	ENST00000522350.1	+	0	476																											ATTTTCTCAAGTTTTTTTTTAA	0.322													2	4	---	---	---	---					
RP11-184E9.1	0	broad.mit.edu	37	5	25227726	25227726	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:25227726delT	ENST00000502100.2	+	0	352				RP11-192H6.2_ENST00000505040.2_lincRNA																							aaaacagctgttttggttact	0.418													2	4	---	---	---	---					
CTD-2353F22.1	0	broad.mit.edu	37	5	36700851	36700852	+	RNA	DEL	AA	AA	-	rs78968819		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:36700851_36700852delAA	ENST00000510740.1	-	0	60																											gatcccatataaaaaaaaaaaa	0.446													3	2	---	---	---	---					
CTD-2116N24.1	0	broad.mit.edu	37	5	38078887	38078887	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:38078887delG	ENST00000513039.2	+	0	233																											AATCATGAAAGCTAACATTGA	0.378													5	6	---	---	---	---					
CTD-2116N24.1	0	broad.mit.edu	37	5	38175801	38175802	+	RNA	DEL	GT	GT	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:38175801_38175802delGT	ENST00000513039.2	+	0	233																											tgtgtgtgtggtgtgtgtgtgt	0.406													4	6	---	---	---	---					
RP11-155L15.1	0	broad.mit.edu	37	5	55610581	55610581	+	RNA	DEL	T	T	-	rs11301421		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:55610581delT	ENST00000504349.1	-	0	377																											TGCTTCCCCCTAGGGGTTCTC	0.567											OREG0016615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	7	---	---	---	---					
RP11-305P14.1	0	broad.mit.edu	37	5	65608444	65608445	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:65608444_65608445insT	ENST00000510964.2	+	0	175																											GAACCATATCCTTTTTTTTTTT	0.371													4	5	---	---	---	---					
CTD-2316B1.1	0	broad.mit.edu	37	5	86963033	86963033	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:86963033delC	ENST00000504287.1	+	0	72																											TAAAAGTTCACCAGGATTCCT	0.274													4	4	---	---	---	---					
MEF2C-AS1	101929423	broad.mit.edu	37	5	88689462	88689463	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:88689462_88689463insA	ENST00000514092.1	+	0	324																											TGTGCAGACAGAAAAAAAAAAT	0.381													2	4	---	---	---	---					
LINC01339	101929495	broad.mit.edu	37	5	89532284	89532285	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:89532284_89532285insT	ENST00000519336.1	-	0	414																											ATTCTTGGTTATTTGTCCCTTA	0.396													3	4	---	---	---	---					
RP11-133F8.2	0	broad.mit.edu	37	5	91748810	91748810	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:91748810delA	ENST00000512210.1	-	0	405																											tggaggggacaaaacatctaa	0.328													2	4	---	---	---	---					
CTD-2337A12.1	0	broad.mit.edu	37	5	95609804	95609804	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:95609804delT	ENST00000511775.1	+	0	35				RP11-254I22.2_ENST00000513926.1_lincRNA|CTD-2337A12.1_ENST00000502645.2_RNA																							AGAGCCCCAAttttttttttt	0.453													3	6	---	---	---	---					
CTD-2337A12.1	0	broad.mit.edu	37	5	95778487	95778487	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:95778487delC	ENST00000502645.2	+	0	354																											TTGGCATTTACCCTACCActg	0.488													3	3	---	---	---	---					
AC008834.1	0	broad.mit.edu	37	5	97491797	97491798	+	RNA	DEL	TG	TG	-	rs140594007	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:97491797_97491798delTG	ENST00000505908.1	-	0	454																											tgtttgtgtttgtgtgtgtgtg	0.411													5	8	---	---	---	---					
RP11-6N13.1	0	broad.mit.edu	37	5	103967762	103967763	+	RNA	DEL	TT	TT	-	rs148269471		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:103967762_103967763delTT	ENST00000503650.1	-	0	328																											ttttttcctctttttttttttt	0.391													3	3	---	---	---	---					
FAM170A	340069	broad.mit.edu	37	5	118969680	118969680	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:118969680delC	ENST00000515256.1	+	3	409	c.237delC	c.(235-237)agfs	p.S79fs				A1A519	F170A_HUMAN	family with sequence similarity 170, member A	79						intracellular	zinc ion binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(7)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	24						ATCGAGACAGCCCCCAGCCTC	0.498													45	80	---	---	---	---					
LOC101927379	101927379	broad.mit.edu	37	5	122056927	122056930	+	RNA	DEL	GAAT	GAAT	-	rs2061512	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:122056927_122056930delGAAT	ENST00000511194.1	-	0	360																											aggaaggaaggaatgaaggaagga	0.407													4	3	---	---	---	---					
CTC-359M8.1	0	broad.mit.edu	37	5	145754228	145754228	+	RNA	DEL	T	T	-	rs77619958		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:145754228delT	ENST00000515598.1	-	0	403				CTC-359M8.1_ENST00000511390.1_RNA																							gcttggctaattttttttttt	0.547													2	4	---	---	---	---					
LOC101927115	101927115	broad.mit.edu	37	5	151465452	151465453	+	RNA	INS	-	-	T	rs72545309		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:151465452_151465453insT	ENST00000524295.1	+	0	199																											TAATCCCAttcttttttttttt	0.431													2	4	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	163801803	163801804	+	RNA	DEL	TG	TG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:163801803_163801804delTG	ENST00000486913.3	+	0	85				CTC-340A15.2_ENST00000519329.1_RNA|CTC-340A15.2_ENST00000517508.1_RNA|CTC-340A15.2_ENST00000523704.1_RNA|CTC-340A15.2_ENST00000524297.1_RNA|CTC-340A15.2_ENST00000522686.1_RNA|CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000519570.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA|CTC-340A15.2_ENST00000523648.1_RNA																							GTGCCACGTCTGTGTGTGTGTG	0.421													3	3	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	164078156	164078156	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:164078156delT	ENST00000517508.1	+	0	716				CTC-340A15.2_ENST00000523704.1_RNA|CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000519570.1_RNA|CTC-340A15.2_ENST00000519750.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA																							caactggctattttttttttt	0.498													2	4	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	164179546	164179548	+	RNA	DEL	TGA	TGA	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:164179546_164179548delTGA	ENST00000517508.1	+	0	759				CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000519570.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA																							CTTTAGGAGGtgatgatgatgat	0.379													3	6	---	---	---	---					
LOC102546299	102546299	broad.mit.edu	37	5	164576069	164576071	+	RNA	DEL	GAC	GAC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr5:164576069_164576071delGAC	ENST00000519570.1	+	0	451				CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA																							CTACCCTGAAGACAGATATTTCT	0.433													4	2	---	---	---	---					
RP11-532F6.5	0	broad.mit.edu	37	6	763463	763463	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:763463delG	ENST00000607084.1	+	0	1207																											actgggaaatggtatggaacg	0.562													10	11	---	---	---	---					
LOC101930126	101930126	broad.mit.edu	37	6	6901984	6901985	+	RNA	INS	-	-	A	rs148250380	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:6901984_6901985insA	ENST00000422310.2	-	0	206																											GGGGCCATCTGAAAAAAAAAGA	0.436													5	5	---	---	---	---					
RP11-716O23.1	0	broad.mit.edu	37	6	11462643	11462644	+	RNA	INS	-	-	A	rs143000125		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:11462643_11462644insA	ENST00000419796.1	+	0	413																											gactcggtctcaaaaaaaaaaa	0.460													4	6	---	---	---	---					
JARID2	3720	broad.mit.edu	37	6	15487634	15487634	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:15487634delA	ENST00000341776.2	+	6	1011	c.767delA	c.(766-768)ccfs	p.H256fs	JARID2_ENST00000397311.3_Frame_Shift_Del_p.H84fs|JARID2_ENST00000541660.1_Frame_Shift_Del_p.H218fs	NM_004973.3	NP_004964.2	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2	256					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				CACAGCGATCACCGGGCTGAC	0.602													24	86	---	---	---	---					
RP11-686D16.1	0	broad.mit.edu	37	6	19313638	19313639	+	RNA	DEL	GT	GT	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:19313638_19313639delGT	ENST00000443504.1	-	0	104																											GAGGCAGCACgtgtgtgtgtgt	0.421													3	5	---	---	---	---					
RP1-209A6.1	0	broad.mit.edu	37	6	22866918	22866918	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:22866918delC	ENST00000420572.2	-	0	197																											tgcctgtagtcccagctactt	0.547													2	4	---	---	---	---					
RP1-209A6.1	0	broad.mit.edu	37	6	22974862	22974864	+	RNA	DEL	AAA	AAA	-	rs142392354		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:22974862_22974864delAAA	ENST00000420572.2	-	0	197																											ttacatgtgcaaaaaaaaacaca	0.350													6	3	---	---	---	---					
RP1-209A6.1	0	broad.mit.edu	37	6	22999350	22999351	+	RNA	DEL	GT	GT	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:22999350_22999351delGT	ENST00000420572.2	-	0	197																											GGTGGTAGTGGTGTGTTGTTTT	0.376													3	4	---	---	---	---					
HIST1H3B	8358	broad.mit.edu	37	6	26031923	26031923	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:26031923delG	ENST00000244661.2	-	1	365	c.366delC	c.(364-366)ccfs	p.P122fs		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	122				P -> L (in Ref. 13; AAH66884).	blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						GGATGTCTTTGGGCATAATAG	0.507													30	96	---	---	---	---					
NKAPL	222698	broad.mit.edu	37	6	28228315	28228316	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:28228315_28228316delGA	ENST00000343684.3	+	1	1218_1219	c.1166_1167delGA	c.(1165-1167)cfs	p.R389fs		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	389										breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						GCCAGTTTCCGAGAGATGGTGC	0.381													32	101	---	---	---	---					
HLA-DRB6	3128	broad.mit.edu	37	6	32526689	32526692	+	RNA	DEL	TGTT	TGTT	-	rs112571645		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:32526689_32526692delTGTT	ENST00000411500.1	-	0	187					NR_001298.1																						cctgtgtgtctgtttggacaaaac	0.461													3	5	---	---	---	---					
TREML2	79865	broad.mit.edu	37	6	41165996	41165996	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:41165996delC	ENST00000483722.1	-	2	412	c.227delG	c.(226-228)ccfs	p.R76fs		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	76	Ig-like V-type.				T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					CAGCAAGTAGCGGGGCCCTTT	0.572													65	166	---	---	---	---					
LOC101927189	101927189	broad.mit.edu	37	6	53852296	53852297	+	RNA	INS	-	-	T	rs112096379	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:53852296_53852297insT	ENST00000431554.2	+	0	325																											AATGTTAAATGTTTTTTGTTAA	0.411													6	1	---	---	---	---					
COL21A1	81578	broad.mit.edu	37	6	56044485	56044485	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:56044485delG	ENST00000244728.5	-	3	928	c.531delC	c.(529-531)gcfs	p.A177fs	COL21A1_ENST00000535941.1_Frame_Shift_Del_p.A177fs|COL21A1_ENST00000370819.1_Frame_Shift_Del_p.A177fs	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	177	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CTCTAAGTTCGGCATCTTCTG	0.393													29	100	---	---	---	---					
LOC101928280	101928280	broad.mit.edu	37	6	69025023	69025024	+	RNA	INS	-	-	AC	rs145244508	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:69025023_69025024insAC	ENST00000445346.1	-	0	237																											tatacatatataCACACACACA	0.312													3	3	---	---	---	---					
RP1-90L14.1	0	broad.mit.edu	37	6	85141655	85141658	+	RNA	DEL	TCCT	TCCT	-	rs10569726		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:85141655_85141658delTCCT	ENST00000454981.1	-	0	289																											cttccttccctccttccttccttc	0.549													6	7	---	---	---	---					
GABRR1	2569	broad.mit.edu	37	6	89891719	89891721	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:89891719_89891721delAAG	ENST00000435811.1	-	7	1255_1257	c.801_803delCTT	c.(799-804)ttg>tt	p.FL267del	GABRR1_ENST00000454853.2_In_Frame_Del_p.FL284del|GABRR1_ENST00000369451.3_In_Frame_Del_p.FL197del	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	284					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AGTTTGGAGCAAGAAGAAGAAGA	0.522													8	383	---	---	---	---					
GJA10	84694	broad.mit.edu	37	6	90605020	90605020	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:90605020delA	ENST00000369352.1	+	1	833	c.833delA	c.(832-834)gafs	p.E278fs		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	278					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TCATTGCCTGAAAGAATCTCT	0.438													52	133	---	---	---	---					
RP1-177I10.1	0	broad.mit.edu	37	6	92100945	92100946	+	RNA	INS	-	-	TT	rs112686302		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:92100945_92100946insTT	ENST00000434493.1	-	0	210																											AATATTTGATCttttttttttt	0.386													2	4	---	---	---	---					
UFL1-AS1	100861530	broad.mit.edu	37	6	96953806	96953807	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:96953806_96953807insA	ENST00000430796.1	-	0	110																											AAATTAATGACATTggctgggc	0.436													4	7	---	---	---	---					
RP11-436D23.1	0	broad.mit.edu	37	6	98558981	98558982	+	RNA	INS	-	-	GT	rs3036462	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:98558981_98558982insGT	ENST00000607823.1	+	0	352																											ggaagtatgacgtgtgtgtgtg	0.366													5	4	---	---	---	---					
RP11-436D23.1	0	broad.mit.edu	37	6	98726122	98726122	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:98726122delC	ENST00000607823.1	+	0	456																											atccatgtcaccactatgggt	0.428													6	6	---	---	---	---					
RP11-436D23.1	0	broad.mit.edu	37	6	98828084	98828084	+	RNA	DEL	T	T	-	rs74707542		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:98828084delT	ENST00000607823.1	+	0	560																											AACCATTGTGTTTTTTTTTAT	0.264													4	5	---	---	---	---					
C6orf183	389422	broad.mit.edu	37	6	109502563	109502564	+	RNA	INS	-	-	C	rs140979531	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:109502563_109502564insC	ENST00000417143.3	+	0	53																											ttctttttgttCCCCCCCACCA	0.421													3	6	---	---	---	---					
LOC101927640	101927640	broad.mit.edu	37	6	112582772	112582772	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:112582772delC	ENST00000587816.1	+	0	111				RP11-506B6.6_ENST00000590584.1_RNA|RP11-506B6.6_ENST00000590293.1_RNA|RP11-506B6.6_ENST00000585611.1_RNA|RP11-506B6.6_ENST00000588837.1_RNA|RP11-506B6.6_ENST00000585504.1_RNA|RP11-506B6.6_ENST00000433684.2_RNA|RP11-506B6.6_ENST00000585450.1_RNA|RP11-506B6.6_ENST00000590804.1_RNA|RP11-506B6.6_ENST00000590673.1_RNA																							GAGGATCCTTCCCCATTGCAA	0.478													2	4	---	---	---	---					
LOC101927640	101927640	broad.mit.edu	37	6	112594622	112594623	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:112594622_112594623insT	ENST00000587816.1	+	0	111				RP11-506B6.6_ENST00000590584.1_RNA|RP11-506B6.6_ENST00000590293.1_RNA|RP11-506B6.6_ENST00000585611.1_RNA|RP11-506B6.6_ENST00000588837.1_RNA|RP11-506B6.6_ENST00000585504.1_RNA|RP11-506B6.6_ENST00000433684.2_RNA|RP11-506B6.6_ENST00000585450.1_RNA|RP11-506B6.6_ENST00000590804.1_RNA|RP11-506B6.6_ENST00000590673.1_RNA																							atttcaccatgttgcccaggct	0.554													8	5	---	---	---	---					
LOC101927640	101927640	broad.mit.edu	37	6	112618410	112618410	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:112618410delT	ENST00000587816.1	+	0	111				RP11-506B6.6_ENST00000590584.1_RNA|RP11-506B6.6_ENST00000585611.1_RNA|RP11-506B6.6_ENST00000585504.1_RNA|RP11-506B6.6_ENST00000433684.2_RNA|RP11-506B6.6_ENST00000585450.1_RNA|RP11-506B6.6_ENST00000590804.1_RNA|RP11-506B6.6_ENST00000590673.1_RNA																							gtgtgtgtagttttttttttt	0.433													3	3	---	---	---	---					
RP11-346D19.1	0	broad.mit.edu	37	6	113859627	113859627	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:113859627delA	ENST00000415883.1	+	0	141																											gaacgcatctaaaaaaaaaaa	0.388													4	8	---	---	---	---					
FLJ34503	285759	broad.mit.edu	37	6	114227499	114227499	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:114227499delC	ENST00000314481.3	+	0	607					NR_027060.1																						ACGTGGAGGACCCAAGGACAG	0.652													3	6	---	---	---	---					
GJA1	2697	broad.mit.edu	37	6	121768887	121768887	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:121768887delC	ENST00000282561.3	+	2	1051	c.894delC	c.(892-894)tgfs	p.C298fs		NM_000165.3	NP_000156.1	P17302	CXA1_HUMAN	gap junction protein, alpha 1, 43kDa	298					cell-cell signaling|cellular membrane organization|gap junction assembly|heart development|muscle contraction|positive regulation of I-kappaB kinase/NF-kappaB cascade	connexon complex|Golgi-associated vesicle membrane|integral to plasma membrane|membrane raft	ion transmembrane transporter activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(2)|large_intestine(10)|liver(2)|lung(13)|ovary(2)	33				GBM - Glioblastoma multiforme(226;0.00252)	Carvedilol(DB01136)	ATTCTTCTTGCCGCAATTACA	0.498													62	159	---	---	---	---					
RP11-624M8.1	0	broad.mit.edu	37	6	125945189	125945189	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:125945189delT	ENST00000451660.2	-	0	548				RP11-624M8.1_ENST00000427852.2_RNA|RP11-624M8.1_ENST00000606334.1_RNA																							AGCTGTCACCTTTTGCAGAAT	0.428													7	4	---	---	---	---					
RP11-624M8.1	0	broad.mit.edu	37	6	125981695	125981695	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:125981695delT	ENST00000451660.2	-	0	443				RP11-624M8.1_ENST00000427852.2_RNA|RP11-624M8.1_ENST00000606334.1_RNA																							TTTAATTCAGTTTAACACATA	0.313													4	3	---	---	---	---					
LINC01010	154092	broad.mit.edu	37	6	134821907	134821907	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:134821907delC	ENST00000431422.1	+	0	275				RP11-557H15.3_ENST00000417483.1_lincRNA	NR_038217.1|NR_038218.1																						cacctgtaaacccaactactc	0.562													6	5	---	---	---	---					
LINC01277	100507489	broad.mit.edu	37	6	143350127	143350128	+	RNA	DEL	TC	TC	-	rs34195526		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:143350127_143350128delTC	ENST00000419957.2	-	0	1089					NR_038987.1																						tactaatgagtcttgtttccca	0.287													5	3	---	---	---	---					
STXBP5-AS1	729178	broad.mit.edu	37	6	147338385	147338385	+	RNA	DEL	T	T	-	rs11309014		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:147338385delT	ENST00000367477.3	-	0	566				STXBP5-AS1_ENST00000447072.1_RNA|STXBP5-AS1_ENST00000431143.1_RNA|STXBP5-AS1_ENST00000458125.1_RNA|STXBP5-AS1_ENST00000427394.1_RNA																							CTGCTTCCACTTTTTTTTTTT	0.358													3	5	---	---	---	---					
FNDC1	84624	broad.mit.edu	37	6	159647539	159647546	+	Frame_Shift_Del	DEL	GCCAGTCA	GCCAGTCA	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:159647539_159647546delGCCAGTCA	ENST00000297267.9	+	9	1307_1314	c.1107_1114delGCCAGTCA	c.(1105-1116)tgatfs	p.WPVN369fs	FNDC1_ENST00000480856.1_3'UTR|FNDC1_ENST00000340366.6_Frame_Shift_Del_p.WPVN369fs	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	369	Fibronectin type-III 4.					extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TGAACGTCTGGCCAGTCAATGGCAAACC	0.447													17	80	---	---	---	---					
RP1-230L10.1	0	broad.mit.edu	37	6	164151533	164151534	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:164151533_164151534insC	ENST00000452944.1	+	0	102																											CCCTTACCACTCCCCCCCAGAT	0.589													2	4	---	---	---	---					
RP11-503C24.1	0	broad.mit.edu	37	6	168596570	168596571	+	RNA	INS	-	-	G	rs146245285	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr6:168596570_168596571insG	ENST00000457340.1	+	0	331																											CCGCGAGCCCAGATCACATCTG	0.545													5	2	---	---	---	---					
LOC100505938	100505938	broad.mit.edu	37	7	8337107	8337108	+	RNA	INS	-	-	A	rs143995334		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:8337107_8337108insA	ENST00000424460.1	+	0	493																											gactccgtctcaaaaaaaaaaa	0.421													2	4	---	---	---	---					
AC004538.3	0	broad.mit.edu	37	7	11233895	11233896	+	RNA	DEL	TT	TT	-	rs141115957	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:11233895_11233896delTT	ENST00000599917.1	+	0	257				AC004538.3_ENST00000428967.1_RNA																							ttttactgtgtttgtgtgtgtg	0.332													2	4	---	---	---	---					
AC005281.1	0	broad.mit.edu	37	7	12536115	12536116	+	RNA	INS	-	-	T	rs141692831	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:12536115_12536116insT	ENST00000418428.2	+	0	61_62																											ctactgtcatcaagggttagta	0.396													6	5	---	---	---	---					
AC007091.1	0	broad.mit.edu	37	7	19399935	19399935	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:19399935delC	ENST00000412563.1	+	0	254																											tatatgtgtgccatggtggtt	0.413													4	4	---	---	---	---					
LINC01162	104355138	broad.mit.edu	37	7	21028271	21028274	+	RNA	DEL	GTGT	GTGT	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:21028271_21028274delGTGT	ENST00000447262.2	+	0	151																											gtgtgtgtgagtgtgtgtgtgtgt	0.422													5	5	---	---	---	---					
AC007255.8	0	broad.mit.edu	37	7	29556792	29556793	+	RNA	INS	-	-	CTGT	rs33974190	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:29556792_29556793insCTGT	ENST00000447171.1	-	0	340																											CACAGTAACTCCTGTCTTTTGG	0.426													5	8	---	---	---	---					
NPSR1-AS1	404744	broad.mit.edu	37	7	34530445	34530447	+	RNA	DEL	AAT	AAT	-	rs10564848		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:34530445_34530447delAAT	ENST00000419766.1	-	0	310					NR_033664.1|NR_033665.1																						gaagatgcacaataataaaatag	0.443													7	6	---	---	---	---					
LINC01448	101928795	broad.mit.edu	37	7	42738057	42738057	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:42738057delG	ENST00000455947.1	-	0	217																											TTCATCCACAGGCAATGATCA	0.393													7	2	---	---	---	---					
AC004901.1	0	broad.mit.edu	37	7	46980727	46980728	+	RNA	INS	-	-	A	rs57902380		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:46980727_46980728insA	ENST00000433337.1	-	0	237																											AAGTGTAAGCCAAAAAAAAAAA	0.411													6	4	---	---	---	---					
AC004901.1	0	broad.mit.edu	37	7	47042514	47042515	+	RNA	INS	-	-	T	rs34402310	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:47042514_47042515insT	ENST00000433337.1	-	0	237				AC004870.3_ENST00000412996.1_RNA																							ctctctaattgtttttttttta	0.475													6	8	---	---	---	---					
LINC01446	401337	broad.mit.edu	37	7	53766964	53766964	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:53766964delG	ENST00000380970.2	-	0	1381					NR_038371.1																						TGAACCAAGTGGGAGAGTTAA	0.413													4	5	---	---	---	---					
LINC01446	401337	broad.mit.edu	37	7	53787886	53787886	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:53787886delC	ENST00000380970.2	-	0	1381					NR_038371.1																						gcaacctctgcctcccggatt	0.458													3	3	---	---	---	---					
GS1-124K5.11	0	broad.mit.edu	37	7	65999903	65999904	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:65999903_65999904insA	ENST00000449307.2	-	0	1308																											gagtccatctgaaaaaaaataa	0.510													2	4	---	---	---	---					
AC003092.2	0	broad.mit.edu	37	7	93704449	93704450	+	RNA	INS	-	-	GT	rs72205452	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:93704449_93704450insGT	ENST00000411946.1	-	0	163																											tgtgtgtgcacgtgtgtgtgtg	0.421													4	4	---	---	---	---					
ZAN	7455	broad.mit.edu	37	7	100352835	100352836	+	RNA	INS	-	-	G	rs145118358	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:100352835_100352836insG	ENST00000542585.1	+	0	3272				ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000538115.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGACAGAGGCTGTTTTCCCCTT	0.545													16	58	---	---	---	---					
LINC01004	100216546	broad.mit.edu	37	7	104632899	104632899	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:104632899delT	ENST00000445184.1	-	0	93				RP11-325F22.3_ENST00000450686.1_RNA																							ATTTGGTCACTTTTTTTTTTG	0.323													4	3	---	---	---	---					
RP11-736E3.1	0	broad.mit.edu	37	7	112769838	112769839	+	RNA	DEL	GA	GA	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:112769838_112769839delGA	ENST00000441928.1	+	0	273																											ctgcacctgtgaggagatgaga	0.446													4	6	---	---	---	---					
LINC01392	104355291	broad.mit.edu	37	7	114706439	114706439	+	RNA	DEL	C	C	-	rs34378948		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:114706439delC	ENST00000419883.1	-	0	544																											ccagtgggagcacaggctcca	0.498													4	3	---	---	---	---					
LINC01392	104355291	broad.mit.edu	37	7	114843259	114843260	+	RNA	DEL	TC	TC	-	rs138338605		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:114843259_114843260delTC	ENST00000419883.1	-	0	173																											ccacttagagtcacccccacca	0.376													6	1	---	---	---	---					
RP11-328J2.1	0	broad.mit.edu	37	7	119535301	119535302	+	RNA	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:119535301_119535302insG	ENST00000426413.1	-	0	83																											tctgcttggctgggggggcccc	0.450													2	4	---	---	---	---					
FEZF1	389549	broad.mit.edu	37	7	121944462	121944462	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:121944462delG	ENST00000442488.2	-	1	97	c.30delC	c.(28-30)acfs	p.T10fs	FEZF1_ENST00000427185.2_Frame_Shift_Del_p.T10fs|FEZF1-AS1_ENST00000428449.1_RNA|FEZF1_ENST00000331178.4_Frame_Shift_Del_p.T10fs	NM_001024613.2|NM_001160264.1	NP_001019784.2|NP_001153736.1	A0PJY2	FEZF1_HUMAN	FEZ family zinc finger 1	10					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|large_intestine(3)|lung(18)|ovary(2)|prostate(1)	25						CTAACATTTTGGTAGTCGCGT	0.592													13	135	---	---	---	---					
RP5-921G16.1	0	broad.mit.edu	37	7	123772364	123772364	+	RNA	DEL	A	A	-	rs5887161		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:123772364delA	ENST00000484322.1	+	0	168																											AAATGGAAATAAAAAAATACG	0.328													4	2	---	---	---	---					
POT1-AS1	401398	broad.mit.edu	37	7	124633805	124633805	+	RNA	DEL	C	C	-	rs1021080	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:124633805delC	ENST00000453342.1	+	0	202																											ccttcaacatcggggatcaat	0.393													6	5	---	---	---	---					
LOC100506682	100506682	broad.mit.edu	37	7	127121637	127121638	+	RNA	DEL	GA	GA	-	rs56255884		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:127121637_127121638delGA	ENST00000448311.1	+	0	264																											cagagggagggagagagagaga	0.401													6	8	---	---	---	---					
LINC-PINT	378805	broad.mit.edu	37	7	130730987	130730988	+	RNA	INS	-	-	AA	rs57459402		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:130730987_130730988insAA	ENST00000451786.1	-	0	1655																											gactctatctcaaaaaaaaaaa	0.470													2	4	---	---	---	---					
LOC101928782	101928782	broad.mit.edu	37	7	131618255	131618256	+	RNA	INS	-	-	GAAGAAGAAGAAAGAAGAG	rs145228204	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:131618255_131618256insGAAGAAGAAGAAAGAAGAG	ENST00000415393.1	+	0	1006																											aagaggaagaagaagaagaaga	0.436													3	4	---	---	---	---					
AC009784.3	0	broad.mit.edu	37	7	135839784	135839784	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:135839784delA	ENST00000445293.2	+	0	230																											ATTTGCCTTCAGGGACACCAC	0.423													4	9	---	---	---	---					
LOC349160	349160	broad.mit.edu	37	7	136501080	136501080	+	RNA	DEL	A	A	-	rs112573715		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:136501080delA	ENST00000439694.1	-	0	343				AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000597642.1_RNA																							gaataaaaacaaaaaaaaaat	0.323													2	4	---	---	---	---					
LOC349160	349160	broad.mit.edu	37	7	136815080	136815081	+	RNA	DEL	AA	AA	-	rs35457374		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:136815080_136815081delAA	ENST00000439694.1	-	0	164				AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000586239.1_RNA|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000599888.1_RNA|AC009264.1_ENST00000597642.1_RNA																							agtctctgtcaaaaaaaaaaaa	0.421													3	4	---	---	---	---					
C7orf13	129790	broad.mit.edu	37	7	156291318	156291321	+	RNA	DEL	ACAC	ACAC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr7:156291318_156291321delACAC	ENST00000447933.1	-	0	300																											agagacacaaacacacacagacac	0.456													7	7	---	---	---	---					
RP11-108E14.1	0	broad.mit.edu	37	8	20543771	20543771	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:20543771delG	ENST00000517706.1	-	0	195																											atcaattaatgggtacaatgt	0.488													5	1	---	---	---	---					
RP11-459E5.1	0	broad.mit.edu	37	8	22566567	22566572	+	RNA	DEL	CATCAC	CATCAC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:22566567_22566572delCATCAC	ENST00000523627.1	+	0	164																											tcaccatcatcatcaccatcaccatc	0.427													3	3	---	---	---	---					
RP11-624C23.1	0	broad.mit.edu	37	8	24500861	24500861	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:24500861delA	ENST00000519689.1	-	0	184																											aatgaggactaaggactttgc	0.413													2	4	---	---	---	---					
RP11-486M23.1	0	broad.mit.edu	37	8	29386802	29386803	+	RNA	INS	-	-	C	rs56410122		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:29386802_29386803insC	ENST00000521101.1	+	0	109																											gagccacaactccggccCAGCC	0.485													4	6	---	---	---	---					
RP11-962G15.1	0	broad.mit.edu	37	8	36636611	36636612	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:36636611_36636612insT	ENST00000524132.1	-	0	70_71																											taaagttgttcttggtttagcc	0.441													7	0	---	---	---	---					
LOC100507420	100507420	broad.mit.edu	37	8	37324625	37324625	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:37324625delT	ENST00000522718.1	-	0	780																											gaatttgaggttaaggaaaag	0.428													2	4	---	---	---	---					
LOC102724623	102724623	broad.mit.edu	37	8	64809621	64809621	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:64809621delT	ENST00000524360.1	-	0	195				RP11-32K4.1_ENST00000521958.1_RNA|RP11-32K4.1_ENST00000523191.1_RNA																							AGTTCTCCGCTTTTTATAACC	0.328													2	4	---	---	---	---					
LINC01299	286186	broad.mit.edu	37	8	66444038	66444038	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:66444038delG	ENST00000520902.1	-	0	1633					NR_033893.1																						aaatgtaaaagaaaggtagag	0.363													6	6	---	---	---	---					
LINC01111	101926978	broad.mit.edu	37	8	77345913	77345913	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:77345913delG	ENST00000518732.1	+	0	160																											AGGAGAGAATGGGGAGCAGAC	0.403													5	5	---	---	---	---					
ZFHX4-AS1	100192378	broad.mit.edu	37	8	77547691	77547702	+	RNA	DEL	TGTGTGTGTGTG	TGTGTGTGTGTG	-	rs138095960		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:77547691_77547702delTGTGTGTGTGTG	ENST00000518143.1	-	0	434				ZFHX4-AS1_ENST00000522961.1_RNA	NR_024360.1																						gtatatgagatgtgtgtgtgtgtgtgtgtgtg	0.311													3	4	---	---	---	---					
LOC102724874	102724874	broad.mit.edu	37	8	78433031	78433032	+	RNA	DEL	GA	GA	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:78433031_78433032delGA	ENST00000518706.2	+	0	527																											gagagagagtgagagagagaga	0.470													2	4	---	---	---	---					
CTA-392E5.1	0	broad.mit.edu	37	8	86861402	86861402	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:86861402delA	ENST00000517368.1	+	0	81																											ATACTTCATTAAAAAAAAAAG	0.353													3	6	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89459999	89460000	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:89459999_89460000insT	ENST00000521433.1	+	0	179				RP11-586K2.1_ENST00000523254.1_RNA																							TCTAAGAAAGCTTTTTTGGCCT	0.322													3	3	---	---	---	---					
LINC00534	100874052	broad.mit.edu	37	8	91352702	91352702	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:91352702delG	ENST00000523406.1	+	0	300					NR_051989.1																						gttacattttggcaaagagac	0.428													7	1	---	---	---	---					
RP11-122C21.1	0	broad.mit.edu	37	8	92800206	92800206	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:92800206delG	ENST00000518416.1	-	0	285																											agccgaagaagggcaaggcat	0.547													2	4	---	---	---	---					
DPYS	1807	broad.mit.edu	37	8	105393457	105393457	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:105393457delG	ENST00000351513.2	-	9	1661	c.1529delC	c.(1528-1530)aafs	p.T510fs	DPYS_ENST00000521601.1_5'UTR	NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	510					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GGTCCCTGCTGTGGCATCTTC	0.502													90	104	---	---	---	---					
LOC101927459	101927459	broad.mit.edu	37	8	111954511	111954514	+	RNA	DEL	AAAC	AAAC	-	rs150269040		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:111954511_111954514delAAAC	ENST00000524283.1	-	0	523																											tcctgtctcaaaacaaacaaacaa	0.426													3	5	---	---	---	---					
LINC00536	100859921	broad.mit.edu	37	8	117261074	117261074	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:117261074delG	ENST00000505156.2	-	0	1333					NR_046215.1																						tcttccaacagggagcaaagc	0.438													4	3	---	---	---	---					
RP11-775B15.2	0	broad.mit.edu	37	8	120460800	120460800	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:120460800delA	ENST00000519786.1	-	0	64																											ctaaaaatacaaaaaaaaaaa	0.478													2	4	---	---	---	---					
RP11-89K10.1	0	broad.mit.edu	37	8	127693006	127693007	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:127693006_127693007insC	ENST00000519880.1	+	0	156																											CGAATGCCTAGCCCCTAATCCC	0.490													2	4	---	---	---	---					
CASC8	727677	broad.mit.edu	37	8	128426102	128426103	+	RNA	INS	-	-	AC	rs3999776	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:128426102_128426103insAC	ENST00000502082.1	-	0	1176				CASC8_ENST00000523825.1_RNA|CASC8_ENST00000501396.1_RNA																							AAAAAGGTGGTacacacacaca	0.317													2	4	---	---	---	---					
RP11-513H8.1	0	broad.mit.edu	37	8	135255583	135255585	+	RNA	DEL	AGA	AGA	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:135255583_135255585delAGA	ENST00000523317.1	-	0	84																											gagaaggaggagaaggaggagga	0.562													2	4	---	---	---	---					
LINC01591	286094	broad.mit.edu	37	8	136252354	136252354	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:136252354delT	ENST00000522279.1	+	0	384					NR_026706.1																						TTATTTTCTCTTGCTGctgtt	0.473													3	5	---	---	---	---					
LYPD2	137797	broad.mit.edu	37	8	143833820	143833821	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr8:143833820_143833821delCC	ENST00000359228.3	-	1	131_132	c.49_50delGG	c.(49-51)afs	p.G17fs		NM_205545.1	NP_991108.1	Q6UXB3	LYPD2_HUMAN	LY6/PLAUR domain containing 2	17						anchored to membrane|plasma membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(2)	7	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					ACCCAGCTCTCCGCAGGCAGCC	0.708													12	22	---	---	---	---					
VLDLR-AS1	401491	broad.mit.edu	37	9	2435599	2435599	+	RNA	DEL	G	G	-	rs112400843		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:2435599delG	ENST00000416826.2	-	0	1214																											gggttttctaggtacacaatc	0.373													15	12	---	---	---	---					
VLDLR-AS1	401491	broad.mit.edu	37	9	2599038	2599039	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:2599038_2599039insC	ENST00000416826.2	-	0	185				RP11-125B21.2_ENST00000453601.1_RNA																							CTAAGATCTGTCTTGGTAGGCA	0.475													9	19	---	---	---	---					
GLIS3	169792	broad.mit.edu	37	9	4303290	4303291	+	RNA	INS	-	-	AT	rs35734431	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:4303290_4303291insAT	ENST00000440674.1	+	0	34																											cacacacacacGAGCTGGCAAC	0.386													9	4	---	---	---	---					
PTPRD	5789	broad.mit.edu	37	9	8317934	8317934	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:8317934delA	ENST00000381196.4	-	43	6222	c.5679delT	c.(5677-5679)tafs	p.Y1893fs	PTPRD_ENST00000360074.4_Frame_Shift_Del_p.Y1880fs|PTPRD_ENST00000356435.5_Frame_Shift_Del_p.Y1893fs|PTPRD_ENST00000486161.1_Frame_Shift_Del_p.Y1486fs|PTPRD_ENST00000397617.3_Frame_Shift_Del_p.Y1486fs|PTPRD_ENST00000355233.5_Frame_Shift_Del_p.Y1487fs|PTPRD_ENST00000358503.5_Frame_Shift_Del_p.Y1871fs|PTPRD_ENST00000537002.1_Frame_Shift_Del_p.Y1483fs|PTPRD_ENST00000397611.3_Frame_Shift_Del_p.Y1483fs|PTPRD_ENST00000540109.1_Frame_Shift_Del_p.Y1893fs|PTPRD_ENST00000397606.3_Frame_Shift_Del_p.Y1486fs	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1893	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGGAAAACTGATATTGATCCT	0.403										TSP Lung(15;0.13)			31	568	---	---	---	---					
LINC00583	100113404	broad.mit.edu	37	9	13937180	13937181	+	RNA	INS	-	-	TCC			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:13937180_13937181insTCC	ENST00000381010.3	+	0	91					NR_038194.1																						TGTGTTAAATGCCCTTTTATTT	0.371													4	9	---	---	---	---					
B4GALT1-AS1	101929639	broad.mit.edu	37	9	33172810	33172811	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:33172810_33172811insT	ENST00000442432.1	+	0	72				RP11-326F20.5_ENST00000426270.1_RNA																							tacctCATTCCTTTTTTTTTTC	0.401													4	5	---	---	---	---					
RP11-311H10.4	0	broad.mit.edu	37	9	33405464	33405467	+	RNA	DEL	ACAG	ACAG	-	rs146357603		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:33405464_33405467delACAG	ENST00000450864.1	+	0	286																											acacacacacacaGAGTTTTATTT	0.456													8	7	---	---	---	---					
ANKRD18B	441459	broad.mit.edu	37	9	33566415	33566416	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:33566415_33566416insT	ENST00000290943.6	+	13	2569_2570	c.2473_2474insT	c.(2473-2475)tggfs	p.W825fs		NM_001244752.1	NP_001231681.1			ankyrin repeat domain 18B											NS(1)|breast(1)|endometrium(2)|lung(1)|prostate(1)|stomach(1)	7						TATGGTAGAACTTGGTAAAGTA	0.302													9	34	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68400860	68400860	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:68400860delC	ENST00000417843.2	-	0	959																											taagtgcattcctggacctgc	0.478													4	9	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68402732	68402733	+	RNA	INS	-	-	TGAAT			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:68402732_68402733insTGAAT	ENST00000417843.2	-	0	224																											ATCTCACATGATGAAGACTAAA	0.287													4	9	---	---	---	---					
PGM5P2	595135	broad.mit.edu	37	9	69128391	69128394	+	RNA	DEL	AAGA	AAGA	-	rs62555835		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:69128391_69128394delAAGA	ENST00000591037.1	-	0	430					NR_002836.2																						tgtctgaaggaagaaaggaaggaa	0.480													6	13	---	---	---	---					
LINC01501	340515	broad.mit.edu	37	9	93253455	93253456	+	RNA	INS	-	-	C	rs138182780	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:93253455_93253456insC	ENST00000449990.1	-	0	647					NR_034157.1																						aaaaaaacaaaaacaaaaaaaa	0.361													3	4	---	---	---	---					
RP11-308N19.1	0	broad.mit.edu	37	9	109230447	109230448	+	RNA	DEL	TG	TG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:109230447_109230448delTG	ENST00000435485.1	+	0	171																											tgtgtgtgcatgtgtgtgtgtg	0.480													3	4	---	---	---	---					
OR1B1	347169	broad.mit.edu	37	9	125391288	125391288	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:125391288delC	ENST00000304833.3	-	1	564	c.527delG	c.(526-528)gcfs	p.G176fs	RP11-64P14.7_ENST00000419604.1_RNA|RP11-64P14.7_ENST00000431442.1_RNA	NM_001004450.1	NP_001004450.1	Q8NGR6	OR1B1_HUMAN	olfactory receptor, family 1, subfamily B, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)	16						GTTAACGTTGCCCCCAGCATC	0.532													50	87	---	---	---	---					
TUBBP5	643224	broad.mit.edu	37	9	141046858	141046859	+	RNA	INS	-	-	A	rs61280752		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr9:141046858_141046859insA	ENST00000503395.1	+	0	196																											tttattgattgatttttttttt	0.460													3	3	---	---	---	---					
LINC00700	282980	broad.mit.edu	37	10	2054495	2054495	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:2054495delG	ENST00000413603.1	-	0	426					NR_040253.1																						CAGGACTGGTGTCCAGACAGG	0.597													6	6	---	---	---	---					
LOC101927964	101927964	broad.mit.edu	37	10	4127143	4127143	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:4127143delT	ENST00000455199.1	+	0	432																											ACCTTTACACttttttttttc	0.403													4	8	---	---	---	---					
LOC101928322	101928322	broad.mit.edu	37	10	10496945	10496947	+	RNA	DEL	CTT	CTT	-	rs10596834		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:10496945_10496947delCTT	ENST00000602311.1	-	0	161																											tttccctctccttctactcatca	0.488													7	8	---	---	---	---					
CAMK1D	57118	broad.mit.edu	37	10	12867680	12867681	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:12867680_12867681insA	ENST00000378847.3	+	10	1367_1368	c.1030_1031insA	c.(1030-1032)aaafs	p.K344fs	CAMK1D_ENST00000378845.1_Frame_Shift_Ins_p.K344fs	NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	344	Ser-rich.					calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		TTTGGCCAGCCAAAAAGACTGT	0.550													8	1768	---	---	---	---					
PTCHD3P1	387647	broad.mit.edu	37	10	29719948	29719949	+	RNA	INS	-	-	TTCC			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:29719948_29719949insTTCC	ENST00000414457.1	+	0	157				PTCHD3P1_ENST00000445521.1_RNA|PTCHD3P1_ENST00000413405.1_RNA|PTCHD3P1_ENST00000430295.1_RNA|PTCHD3P1_ENST00000423223.1_RNA|PTCHD3P1_ENST00000438202.1_RNA|PTCHD3P1_ENST00000455774.1_RNA|PTCHD3P1_ENST00000446807.1_RNA																							TGATATGATATttccttccttc	0.401													4	9	---	---	---	---					
RP11-168P8.5	0	broad.mit.edu	37	10	44397698	44397699	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:44397698_44397699insC	ENST00000438454.1	-	0	34																											TTCCCTGTGCTCCCCCcatttt	0.599													2	4	---	---	---	---					
RP11-556E13.1	0	broad.mit.edu	37	10	54453663	54453663	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:54453663delC	ENST00000443523.1	-	0	100																											GCCTGAGCTTCCATTTCCATT	0.353													4	8	---	---	---	---					
RP11-96C23.14	0	broad.mit.edu	37	10	88776081	88776086	+	RNA	DEL	TCCTCC	TCCTCC	-	rs71019450		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:88776081_88776086delTCCTCC	ENST00000444180.3	+	0	983																											ctccttctcttcctcctcctcctcct	0.481													6	4	---	---	---	---					
NUTM2A-AS1	728190	broad.mit.edu	37	10	88964775	88964775	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:88964775delG	ENST00000451940.2	-	0	600																											ttcaggcattgggcgggtagc	0.478													17	2	---	---	---	---					
LOC283038	283038	broad.mit.edu	37	10	127392351	127392352	+	RNA	DEL	AG	AG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:127392351_127392352delAG	ENST00000415305.2	+	0	324					NR_033848.1																						AAAAAAAAAAAGGGAAAAAGAA	0.327													2	4	---	---	---	---					
TCERG1L	256536	broad.mit.edu	37	10	133058640	133058641	+	In_Frame_Ins	INS	-	-	GCG			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr10:133058640_133058641insGCG	ENST00000368642.4	-	4	822_823	c.737_738insCGC	c.(736-738)ggc>gCGCgc	p.246_246G>AR		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	246	Poly-Ala.									cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		AGACCATggcagcggcggcggc	0.668													4	4	---	---	---	---					
KRTAP5-1	387264	broad.mit.edu	37	11	1605904	1605904	+	Frame_Shift_Del	DEL	T	T	-	rs113408385		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:1605904delT	ENST00000382171.2	-	1	609	c.576delA	c.(574-576)ggfs	p.G192fs	KRTAP5-AS1_ENST00000424148.1_RNA|KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	192	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCCCTTGGATCCCCCACAAG	0.677													13	155	---	---	---	---					
KRTAP5-1	387264	broad.mit.edu	37	11	1605965	1605965	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:1605965delC	ENST00000382171.2	-	1	548	c.515delG	c.(514-516)gcfs	p.G172fs	KRTAP5-AS1_ENST00000424148.1_RNA|KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	172	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCCTTGGAGCCCCCACAAGA	0.672													25	268	---	---	---	---					
KRTAP5-2	440021	broad.mit.edu	37	11	1619173	1619202	+	In_Frame_Del	DEL	CCCCCACAGGAGCCACAGCCCCCCTTGGAG	CCCCCACAGGAGCCACAGCCCCCCTTGGAG	-	rs61869706	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:1619173_1619202delCCCCCACAGGAGCCACAGCCCCCCTTGGAG	ENST00000412090.1	-	1	322_351	c.279_308delCTCCAAGGGGGGCTGTGGCTCCTGTGGGGG	c.(277-309)ggt>gg	p.GSKGGCGSCGG93del	KRTAP5-AS1_ENST00000424148.1_RNA	NM_001004325.1	NP_001004325.1	Q701N4	KRA52_HUMAN	keratin associated protein 5-2	93	6 X 4 AA repeats of C-C-X-P.					keratin filament				large_intestine(1)|lung(2)|skin(1)	4		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCCCTTGGAACCCCCACAGGAGCCACAGCCCCCCTTGGAGCCCCCACAGG	0.657													35	333	---	---	---	---					
LOC101927708	101927708	broad.mit.edu	37	11	3509422	3509423	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:3509422_3509423insA	ENST00000527970.1	-	0	605				RP13-726E6.1_ENST00000534291.1_lincRNA																							aatgccaccccaggaattgcac	0.475													4	4	---	---	---	---					
OVCH2	341277	broad.mit.edu	37	11	7722922	7722922	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:7722922delC	ENST00000454689.1	-	0	659				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GAAAGGTCTTCCCACTGATGG	0.552													28	37	---	---	---	---					
GALNT18	374378	broad.mit.edu	37	11	11643002	11643002	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:11643002delC	ENST00000227756.4	-	1	550	c.139delG	c.(139-141)cgfs	p.A47fs	GALNT18_ENST00000526064.1_5'UTR	NM_198516.2	NP_940918.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 18																		TTGTCGGGCGCCGGCTCCTGC	0.562													31	4	---	---	---	---					
CTC-497E21.5	0	broad.mit.edu	37	11	13107360	13107360	+	RNA	DEL	T	T	-	rs35985995		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:13107360delT	ENST00000531136.1	-	0	47																											CTGTAAAAAATTTTTTTTAAG	0.393													7	1	---	---	---	---					
CTC-497E21.5	0	broad.mit.edu	37	11	13125616	13125617	+	RNA	INS	-	-	AAG	rs71041509	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:13125616_13125617insAAG	ENST00000531136.1	-	0	47																											agaaaagaaaaaaggaggagga	0.332													6	3	---	---	---	---					
RP11-531H8.2	0	broad.mit.edu	37	11	15616078	15616078	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:15616078delG	ENST00000533082.1	-	0	87																											atgaatctatgggccgaggct	0.577													15	1	---	---	---	---					
RP11-405K6.1	0	broad.mit.edu	37	11	25787312	25787313	+	RNA	INS	-	-	T	rs66510258	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:25787312_25787313insT	ENST00000533942.1	+	0	146																											TGTTACCTGTGTTTTTCATCTA	0.356													8	3	---	---	---	---					
BBOX1-AS1	103695435	broad.mit.edu	37	11	27172862	27172863	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:27172862_27172863insA	ENST00000530430.1	-	0	564				RP11-1L12.3_ENST00000525302.1_RNA|RP11-1L12.3_ENST00000526061.1_RNA																							ttggggattacaattgaacatg	0.446													4	3	---	---	---	---					
BDNF-AS	497258	broad.mit.edu	37	11	27575975	27575976	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:27575975_27575976insT	ENST00000499008.3	+	0	144				BDNF-AS_ENST00000500662.2_RNA|BDNF-AS_ENST00000501176.2_RNA|BDNF-AS_ENST00000499568.2_RNA|BDNF-AS_ENST00000530686.1_RNA|BDNF-AS_ENST00000532965.1_RNA|BDNF-AS_ENST00000502161.2_RNA	NR_002832.2																						gcaagatcccattttttcacag	0.416													2	4	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	28810400	28810401	+	RNA	INS	-	-	T	rs60511861		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:28810400_28810401insT	ENST00000513853.1	+	0	304																											atttaaagtacttttttttttt	0.356													7	3	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	28811019	28811021	+	RNA	DEL	TTA	TTA	-	rs144149460		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:28811019_28811021delTTA	ENST00000513853.1	+	0	304																											taaatagctcttattattttcag	0.350													5	1	---	---	---	---					
RP11-115J23.1	0	broad.mit.edu	37	11	28811063	28811064	+	RNA	INS	-	-	T	rs139083488	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:28811063_28811064insT	ENST00000513853.1	+	0	304																											tttattgagagttttttttttc	0.312													8	2	---	---	---	---					
RP11-466I1.1	0	broad.mit.edu	37	11	29279814	29279814	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:29279814delC	ENST00000530960.1	+	0	295																											agcttgttgacttttttttgt	0.313													7	0	---	---	---	---					
APIP	51074	broad.mit.edu	37	11	34904908	34904909	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:34904908_34904909insC	ENST00000395787.3	-	6	818_819	c.604_605insG	c.(604-606)aacfs	p.N202fs	APIP_ENST00000527830.1_5'UTR|APIP_ENST00000278359.5_Frame_Shift_Ins_p.N219fs	NM_015957.2	NP_057041.2	Q96GX9	MTNB_HUMAN	APAF1 interacting protein	202					apoptosis|L-methionine salvage	cytoplasm	identical protein binding|metal ion binding|methylthioribulose 1-phosphate dehydratase activity			kidney(2)|lung(1)|skin(1)	4	all_epithelial(35;0.161)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.000425)			CTCCCATGTTTCCCCCCACACA	0.450													15	695	---	---	---	---					
RP11-124G5.3	0	broad.mit.edu	37	11	41554479	41554479	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:41554479delC	ENST00000526978.1	-	0	519																											TATTCTATTTCCGAAGTGATG	0.373													5	10	---	---	---	---					
RP11-430H10.4	0	broad.mit.edu	37	11	45470387	45470388	+	RNA	INS	-	-	GT	rs3061758	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:45470387_45470388insGT	ENST00000528445.1	-	0	535																											TGCGTGTGCAAGCATGTTCCCA	0.564													12	14	---	---	---	---					
NR1H3	10062	broad.mit.edu	37	11	47282886	47282887	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:47282886_47282887insC	ENST00000467728.1	+	4	1832_1833	c.594_595insC	c.(592-597)tcccccfs	p.SP198fs	NR1H3_ENST00000407404.1_Frame_Shift_Ins_p.SP198fs|NR1H3_ENST00000481889.2_Frame_Shift_Ins_p.SP153fs|NR1H3_ENST00000405853.3_Frame_Shift_Ins_p.SP198fs|NR1H3_ENST00000395397.3_Frame_Shift_Ins_p.SP153fs|NR1H3_ENST00000441012.2_Frame_Shift_Ins_p.SP198fs|NR1H3_ENST00000527949.1_Frame_Shift_Ins_p.SP107fs|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000405576.1_Frame_Shift_Ins_p.SP153fs			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	198					apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						GGGCTTCCTCACCCCCCCAAAT	0.594													9	152	---	---	---	---					
RP11-574M7.1	0	broad.mit.edu	37	11	50300216	50300216	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:50300216delG	ENST00000528459.1	+	0	454																											TTCTACTCCAGCTGGACTCTG	0.413													6	2	---	---	---	---					
OR5D16	390144	broad.mit.edu	37	11	55606395	55606396	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55606395_55606396insT	ENST00000378396.1	+	1	168_169	c.168_169insT	c.(166-171)aatgcafs	p.A57fs		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TTAACCCAAAATTGCATACCCC	0.436													142	402	---	---	---	---					
OR5D16	390144	broad.mit.edu	37	11	55606547	55606547	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55606547delG	ENST00000378396.1	+	1	320	c.320delG	c.(319-321)tcfs	p.C107fs		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TTTTTCTTTTGCACCTTTGTA	0.433													369	237	---	---	---	---					
OR5I1	10798	broad.mit.edu	37	11	55703382	55703382	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:55703382delG	ENST00000301532.3	-	1	494	c.495delC	c.(493-495)gcfs	p.A165fs		NM_006637.1	NP_006628.1	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I, member 1	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(34)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	52						TCAGAATAAAGGCAAAGGATG	0.398													103	82	---	---	---	---					
STX3	6809	broad.mit.edu	37	11	59564806	59564807	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:59564806_59564807insT	ENST00000535361.1	+	9	1273_1274	c.726_727insT	c.(724-729)gctgatfs	p.D243fs	STX3_ENST00000529177.1_Intron|STX3_ENST00000300150.7_Frame_Shift_Ins_p.D249fs|STX3_ENST00000337979.4_Frame_Shift_Ins_p.D280fs|STX3_ENST00000437946.2_Intron			Q13277	STX3_HUMAN	syntaxin 3	280	t-SNARE coiled-coil homology.				cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|skin(1)	13						GCATTTTAGCATTGATTATTGG	0.386													55	145	---	---	---	---					
NXF1	10482	broad.mit.edu	37	11	62571028	62571028	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:62571028delG	ENST00000531709.2	-	3	345	c.232delC	c.(232-234)gafs	p.R78fs	NXF1_ENST00000294172.2_Frame_Shift_Del_p.R78fs|NXF1_ENST00000532297.1_Frame_Shift_Del_p.R78fs|NXF1_ENST00000531131.1_Intron|NXF1_ENST00000439713.2_Frame_Shift_Del_p.R78fs	NM_001081491.1	NP_001074960.1	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	78	Interaction with THOC4.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding	p.R78*(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CGGTTAGGTCGGGTGGTATAG	0.517													173	74	---	---	---	---					
PCNXL3	399909	broad.mit.edu	37	11	65387817	65387818	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:65387817_65387818insC	ENST00000355703.3	+	9	2555_2556	c.2016_2017insC	c.(2014-2019)cggttcfs	p.F673fs		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	673						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CAGGTGTGCGGCGTTCCTACAC	0.624													10	15	---	---	---	---					
RP11-626H12.2	0	broad.mit.edu	37	11	69862131	69862131	+	RNA	DEL	T	T	-	rs5792504		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:69862131delT	ENST00000528507.1	-	0	301																											CCtttctttcttttttttttt	0.493													4	9	---	---	---	---					
KRTAP5-10	387273	broad.mit.edu	37	11	71276660	71276661	+	In_Frame_Ins	INS	-	-	TGTGGCTCCGGCTGTGGGGGC	rs141048398		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:71276660_71276661insTGTGGCTCCGGCTGTGGGGGC	ENST00000398531.1	+	1	52_53	c.27_28insTGTGGCTCCGGCTGTGGGGGC	c.(25-30)gggtgg>ggTGTGGCTCCGGCTGTGGGGGCgtgg	p.9_10GW>GVAPAVGAW	KRTAP5-10_ENST00000376536.4_In_Frame_Ins_p.9_10GW>GVAPAVGAW	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	9						keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						GCTCCGGAGGCTGTGGCTCCGG	0.663													9	214	---	---	---	---					
INPPL1	3636	broad.mit.edu	37	11	71948208	71948209	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:71948208_71948209insC	ENST00000541756.1	+	26	3124_3125	c.2194_2195insC	c.(2194-2196)cccfs	p.P732fs	INPPL1_ENST00000538751.1_Frame_Shift_Ins_p.P732fs|INPPL1_ENST00000298229.2_Frame_Shift_Ins_p.P974fs			O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	974					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding	p.P977fs*7(1)		breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						AGGGGTGGCGGCCCCCCCACCC	0.634													7	104	---	---	---	---					
SERPINH1	871	broad.mit.edu	37	11	75277761	75277762	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:75277761_75277762delGC	ENST00000524558.1	+	2	1802_1803	c.367_368delGC	c.(367-369)gfs	p.A123fs	SERPINH1_ENST00000358171.3_Frame_Shift_Del_p.A123fs|SERPINH1_ENST00000533603.1_Frame_Shift_Del_p.A123fs|SERPINH1_ENST00000530284.1_Frame_Shift_Del_p.A123fs			P50454	SERPH_HUMAN	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	123					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			endometrium(4)|large_intestine(3)|liver(1)|lung(4)|ovary(2)|stomach(1)	15	Ovarian(111;0.11)					CAACTCCACGGCGCGCAACGTG	0.668													12	24	---	---	---	---					
LOC101928944	101928944	broad.mit.edu	37	11	80467773	80467774	+	RNA	INS	-	-	TCTC	rs148887605	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:80467773_80467774insTCTC	ENST00000526840.1	-	0	940																											ctctctctctttctctgtgtgt	0.386													5	9	---	---	---	---					
LOC101928989	101928989	broad.mit.edu	37	11	81601893	81601894	+	RNA	INS	-	-	T	rs149503927	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:81601893_81601894insT	ENST00000500502.1	-	0	940																											AAACACTGGGGTTTTTTTTTTG	0.337													3	4	---	---	---	---					
LOC101928989	101928989	broad.mit.edu	37	11	82017435	82017435	+	RNA	DEL	T	T	-	rs68014912		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:82017435delT	ENST00000500502.1	-	0	431																											TTTTCTTTTCTTttttttttt	0.388													5	2	---	---	---	---					
RP11-727A23.10	0	broad.mit.edu	37	11	83025468	83025469	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:83025468_83025469insA	ENST00000530045.1	+	0	482																											aagactctgtcaaaaaaaaaaa	0.460													3	5	---	---	---	---					
DISC1FP1	101929222	broad.mit.edu	37	11	90549855	90549856	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:90549855_90549856insA	ENST00000562678.1	+	0	282																											taaagtaTAATAAAAAAAAAAA	0.406													3	4	---	---	---	---					
WTAPP1	100288077	broad.mit.edu	37	11	102677925	102677925	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:102677925delG	ENST00000525739.2	+	0	682					NR_038390.1																						CAACAGGAGTGGGCATCTTCT	0.418													18	35	---	---	---	---					
RP11-563P16.1	0	broad.mit.edu	37	11	103570475	103570476	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:103570475_103570476insC	ENST00000533459.1	-	0	272																											cttccttccttccttccttcct	0.559													4	8	---	---	---	---					
RP11-94P11.4	0	broad.mit.edu	37	11	105158746	105158747	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:105158746_105158747insA	ENST00000528811.1	-	0	96																											gttcccagcacaaaacaataac	0.342													2	4	---	---	---	---					
AP000797.4	0	broad.mit.edu	37	11	115811308	115811309	+	RNA	INS	-	-	T	rs143975391	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:115811308_115811309insT	ENST00000537491.1	+	0	293																											gtatctacctctttttgcttaa	0.317													4	5	---	---	---	---					
USP2-AS1	100499227	broad.mit.edu	37	11	119326360	119326360	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:119326360delA	ENST00000498979.2	+	0	273				USP2-AS1_ENST00000530002.1_RNA|USP2-AS1_ENST00000500970.1_RNA|USP2-AS1_ENST00000578923.1_RNA	NR_034160.1																						gtgtcaaaataaaataaaaat	0.249													2	4	---	---	---	---					
RP11-820L6.1	0	broad.mit.edu	37	11	122106247	122106247	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr11:122106247delT	ENST00000527474.1	-	0	898																											GGatatagcctaccttctaat	0.418													2	4	---	---	---	---					
IQSEC3	440073	broad.mit.edu	37	12	234956	234968	+	Frame_Shift_Del	DEL	AGGGCTGGCCCCC	AGGGCTGGCCCCC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:234956_234968delAGGGCTGGCCCCC	ENST00000538872.1	+	3	899_911	c.781_793delAGGGCTGGCCCCC	c.(781-795)agfs	p.RAGPQ261fs	IQSEC3_ENST00000326261.4_Frame_Shift_Del_p.RAGPQ261fs|IQSEC3_ENST00000382841.2_Intron			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	261					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TGCCTCCCCAAGGGCTGGCCCCCAGCACAAGGC	0.732													5	5	---	---	---	---					
KDM5A	5927	broad.mit.edu	37	12	443549	443558	+	Frame_Shift_Del	DEL	CAGGCATGTT	CAGGCATGTT	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:443549_443558delCAGGCATGTT	ENST00000399788.2	-	11	1701_1710	c.1339_1348delAACATGCCTG	c.(1339-1350)tcfs	p.NMPV447fs	KDM5A_ENST00000382815.4_Frame_Shift_Del_p.NMPV447fs	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	447	JmjC.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						TGTTCCAGGACAGGCATGTTATTCAAATTC	0.395			T	NUP98	AML								79	845	---	---	---	---					
LINC00940	100271702	broad.mit.edu	37	12	2042054	2042057	+	RNA	DEL	ATGT	ATGT	-	rs150655645		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:2042054_2042057delATGT	ENST00000418006.1	-	0	121					NR_036546.1																						TATTGTGTTAAtgtatgtgtgcat	0.466													11	20	---	---	---	---					
RP11-664D1.1	0	broad.mit.edu	37	12	3991877	3991878	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:3991877_3991878insC	ENST00000537149.1	+	0	223																											TGCAGATTGAACAGGGCGTGGT	0.411													8	8	---	---	---	---					
LOC374443	374443	broad.mit.edu	37	12	9804650	9804651	+	RNA	INS	-	-	T	rs35960718		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:9804650_9804651insT	ENST00000575094.1	+	0	887					NR_002814.2|NR_046451.1																						ccttttcagggttttttttcta	0.277													2	4	---	---	---	---					
RP11-405A12.2	0	broad.mit.edu	37	12	20062987	20062988	+	RNA	INS	-	-	TCTA	rs71067099	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:20062987_20062988insTCTA	ENST00000535764.1	+	0	153																											aactctatctgtctatctatct	0.416													3	4	---	---	---	---					
RP11-630C16.2	0	broad.mit.edu	37	12	42281345	42281345	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:42281345delA	ENST00000550874.1	-	0	471																											gatttaaaagaaaaaaagtta	0.338													2	4	---	---	---	---					
RP11-478B9.1	0	broad.mit.edu	37	12	45461862	45461862	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:45461862delA	ENST00000548424.1	+	0	448																											agaactgcccaagactgagta	0.423													8	6	---	---	---	---					
RP11-352M15.1	0	broad.mit.edu	37	12	45981853	45981853	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:45981853delT	ENST00000551229.2	-	0	173																											taaaacatgatttctgggtgt	0.443													5	8	---	---	---	---					
RP11-370I10.6	0	broad.mit.edu	37	12	48810645	48810646	+	RNA	INS	-	-	A	rs141405694	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:48810645_48810646insA	ENST00000548257.1	+	0	237																											actccatctccaaaaaaaaaag	0.470													3	3	---	---	---	---					
HOTAIR	100124700	broad.mit.edu	37	12	54362585	54362586	+	RNA	INS	-	-	C	rs74613444	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:54362585_54362586insC	ENST00000424518.1	-	0	59				HOTAIR_ENST00000455246.1_RNA|HOTAIR_ENST00000439545.1_RNA	NR_003716.3																						GGGCAAAAGATTTTTTTTTGTT	0.455													5	10	---	---	---	---					
TESPA1	9840	broad.mit.edu	37	12	55359857	55359857	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:55359857delC	ENST00000524622.1	-	5	673	c.12delG	c.(10-12)ggfs	p.G4fs	TESPA1_ENST00000532804.1_Frame_Shift_Del_p.G4fs|TESPA1_ENST00000449076.1_Frame_Shift_Del_p.G142fs|TESPA1_ENST00000531122.1_Frame_Shift_Del_p.G4fs|TESPA1_ENST00000524959.1_Intron|TESPA1_ENST00000316577.8_Frame_Shift_Del_p.G142fs	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	142																	TCTTGTTGGTCCCCCCAGTCA	0.512													78	74	---	---	---	---					
LINC01481	101928062	broad.mit.edu	37	12	70599961	70599962	+	RNA	INS	-	-	AT	rs147974172	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:70599961_70599962insAT	ENST00000549419.1	-	0	144																											ATTACTATGCCATATATATATA	0.376													3	3	---	---	---	---					
RP11-314D7.4	0	broad.mit.edu	37	12	73993095	73993096	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:73993095_73993096insT	ENST00000549058.1	-	0	97																											ACATTTTCTACTTTTTGTCCCT	0.391													2	4	---	---	---	---					
RP11-314D7.4	0	broad.mit.edu	37	12	74097572	74097572	+	RNA	DEL	A	A	-	rs56319541		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:74097572delA	ENST00000549058.1	-	0	97																											aggaacaaacaaagcctccaa	0.343													10	1	---	---	---	---					
RP11-114H23.1	0	broad.mit.edu	37	12	75965448	75965448	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:75965448delG	ENST00000552856.1	-	0	549																											ACTTACAGCAGGTCACTACTT	0.348													6	1	---	---	---	---					
RP11-54A9.1	0	broad.mit.edu	37	12	76687023	76687023	+	RNA	DEL	T	T	-	rs112647681		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:76687023delT	ENST00000553247.1	+	0	232																											cctccccccctgcccaacaat	0.507													4	2	---	---	---	---					
RP11-13A1.3	0	broad.mit.edu	37	12	89641775	89641775	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:89641775delG	ENST00000549278.1	-	0	144																											AGTAAAGGCAGGCTTCAGTAG	0.378													10	0	---	---	---	---					
RP11-511B23.2	0	broad.mit.edu	37	12	93432988	93432988	+	RNA	DEL	G	G	-	rs11291134	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:93432988delG	ENST00000550324.1	-	0	85				RP11-511B23.2_ENST00000549930.1_RNA																							agatagagacggggggtgtgt	0.478													4	2	---	---	---	---					
RP11-541G9.1	0	broad.mit.edu	37	12	97547146	97547147	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:97547146_97547147insT	ENST00000552238.1	+	0	39																											TCTCTCCCTCCTGTGCATGTGA	0.391													6	0	---	---	---	---					
RP11-357K6.3	0	broad.mit.edu	37	12	119303261	119303261	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:119303261delC	ENST00000544515.1	-	0	256																											CACCACTTTTCAGAAATGCCA	0.502													13	0	---	---	---	---					
CABP1	9478	broad.mit.edu	37	12	121093820	121093820	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:121093820delC	ENST00000453000.1	+	1	719	c.207delC	c.(205-207)ctfs	p.L69fs	CABP1_ENST00000351200.2_Intron|CABP1_ENST00000316803.3_Intron|CABP1_ENST00000288616.3_Intron			Q9NZU7	CABP1_HUMAN	calcium binding protein 1	44						cell cortex|cell junction|Golgi apparatus|perinuclear region of cytoplasm|postsynaptic density|postsynaptic membrane	calcium ion binding|calcium-dependent protein binding|enzyme inhibitor activity|protein binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(6)	9	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					GAAAGCCCCTCCCGGGACCAG	0.602													7	8	---	---	---	---					
ZCCHC8	55596	broad.mit.edu	37	12	122968060	122968060	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:122968060delC	ENST00000336229.4	-	6	682	c.552delG	c.(550-552)ggfs	p.G184fs	ZCCHC8_ENST00000536306.1_Intron|ZCCHC8_ENST00000543897.1_5'UTR	NM_017612.3	NP_060082.2	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	184						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GAAGCGGTTGCCCCAATTTAT	0.363													33	5	---	---	---	---					
PXMP2	5827	broad.mit.edu	37	12	133277869	133277870	+	Frame_Shift_Ins	INS	-	-	G	rs141115887	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr12:133277869_133277870insG	ENST00000545677.1	+	3	250_251	c.47_48insG	c.(46-48)gggfs	p.G16fs	PXMP2_ENST00000317479.3_Frame_Shift_Ins_p.G145fs|PXMP2_ENST00000543589.1_Intron|RP13-672B3.2_ENST00000537262.1_Frame_Shift_Ins_p.G16fs|PXMP2_ENST00000539093.1_Frame_Shift_Ins_p.G16fs|PXMP2_ENST00000428960.2_Frame_Shift_Ins_p.G52fs			Q9NR77	PXMP2_HUMAN	peroxisomal membrane protein 2, 22kDa	0						integral to membrane|peroxisomal membrane	protein binding			large_intestine(1)|liver(2)|lung(1)	4	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.86e-08)|Epithelial(86;2.47e-07)|all cancers(50;6.85e-06)		CGCCAAGATGAGGGGGGGCTTC	0.614													7	100	---	---	---	---					
SPATA13	221178	broad.mit.edu	37	13	24798263	24798264	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:24798263_24798264insG	ENST00000424834.2	+	4	1669_1670	c.1196_1197insG	c.(1195-1197)aggfs	p.R399fs	SPATA13_ENST00000382095.4_Intron|SPATA13_ENST00000382108.3_Frame_Shift_Ins_p.R399fs			Q96N96	SPT13_HUMAN	spermatogenesis associated 13	0	DH.				cell migration|filopodium assembly|lamellipodium assembly|regulation of cell migration|regulation of Rho protein signal transduction	cytoplasm|filopodium|lamellipodium|ruffle membrane	protein binding|Rac guanyl-nucleotide exchange factor activity			breast(4)|endometrium(2)|large_intestine(9)|lung(4)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(29;4.05e-15)|all_lung(29;2.77e-14)|all_epithelial(30;7.77e-13)|Lung SC(185;0.0279)		all cancers(112;0.00616)|Epithelial(112;0.0195)|OV - Ovarian serous cystadenocarcinoma(117;0.0705)|Lung(94;0.231)		GCCACCTCTAAGGGGCCCCACC	0.614													2	4	---	---	---	---					
RP11-16D22.2	0	broad.mit.edu	37	13	34923094	34923094	+	RNA	DEL	G	G	-	rs59339478	byFrequency	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:34923094delG	ENST00000605909.1	+	0	82																											gtttttttttgtttGTTTGTT	0.378													2	4	---	---	---	---					
RNF219-AS1	100874222	broad.mit.edu	37	13	79162513	79162518	+	RNA	DEL	TGTGTG	TGTGTG	-	rs71658008		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:79162513_79162518delTGTGTG	ENST00000606429.1	+	0	384				RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000430549.2_RNA	NR_047001.1																						TGGGTTCGGTtgtgtgtgtgtgtgtg	0.354													3	5	---	---	---	---					
RP11-366K1.1	0	broad.mit.edu	37	13	87569419	87569419	+	RNA	DEL	A	A	-	rs71128969		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:87569419delA	ENST00000457672.2	+	0	64																											catgaatgtgaaaaaaaaaaa	0.373													5	11	---	---	---	---					
LINC00410	144776	broad.mit.edu	37	13	91569757	91569758	+	RNA	DEL	AT	AT	-	rs75290709		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:91569757_91569758delAT	ENST00000419272.1	-	0	117					NR_027039.1																						CTCTTAGCACATAGAGTCTAGA	0.312													10	4	---	---	---	---					
LINC00379	100874150	broad.mit.edu	37	13	91783368	91783369	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:91783368_91783369insC	ENST00000438789.1	-	0	143																											aggataatggtcccccggagat	0.416													2	4	---	---	---	---					
RP11-123H22.1	0	broad.mit.edu	37	13	104078053	104078053	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr13:104078053delG	ENST00000444795.1	+	0	122																											ATGGGAAGGAGGGGAGGTGTA	0.378													4	4	---	---	---	---					
RP11-146E13.4	0	broad.mit.edu	37	14	19818386	19818386	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:19818386delC	ENST00000548109.1	+	0	72																											ctcgctctgtcccccaggctg	0.478													3	5	---	---	---	---					
OR4K5	79317	broad.mit.edu	37	14	20389640	20389640	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:20389640delG	ENST00000315915.4	+	1	900	c.875delG	c.(874-876)agfs	p.R292fs		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R292T(1)		central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTAAGGAATAGGGATATGAAG	0.403													179	602	---	---	---	---					
LINC00645	100505967	broad.mit.edu	37	14	28103894	28103894	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:28103894delT	ENST00000557399.1	+	0	295				CTD-3006G17.2_ENST00000553392.1_RNA	NR_039992.1																						TGCTGCATGGTTTTTTTTTTC	0.393													5	9	---	---	---	---					
LOC728755	728755	broad.mit.edu	37	14	28113701	28113701	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:28113701delA	ENST00000553392.1	-	0	262																											agaaaggcagaaaaaaaaaaa	0.353													2	4	---	---	---	---					
CTD-2591A6.2	0	broad.mit.edu	37	14	28787670	28787670	+	RNA	DEL	G	G	-	rs71436325		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:28787670delG	ENST00000548280.1	+	0	324																											accgtcttctggcgtcgctca	0.527													3	4	---	---	---	---					
CTD-2591A6.2	0	broad.mit.edu	37	14	28885549	28885549	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:28885549delC	ENST00000548280.1	+	0	439																											gaatgccagtcccctgggtcc	0.458													7	3	---	---	---	---					
RP11-148E17.1	0	broad.mit.edu	37	14	29458349	29458352	+	RNA	DEL	TTTG	TTTG	-	rs112068752		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:29458349_29458352delTTTG	ENST00000551227.1	+	0	244																											ATATTGGGTTtttgtttgtttgtt	0.402													3	4	---	---	---	---					
RP11-148E17.1	0	broad.mit.edu	37	14	29461857	29461858	+	RNA	INS	-	-	A	rs149799801	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:29461857_29461858insA	ENST00000551227.1	+	0	244																											atggtggatatgggatttgaaa	0.396													4	8	---	---	---	---					
CTD-2251F13.1	0	broad.mit.edu	37	14	30710011	30710011	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:30710011delG	ENST00000508469.2	-	0	69																											TCTCAACGTAGGGGTTTGGAA	0.433													2	4	---	---	---	---					
RP11-159L20.2	0	broad.mit.edu	37	14	31282679	31282680	+	RNA	INS	-	-	G	rs112176193	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:31282679_31282680insG	ENST00000554665.1	-	0	208																											cagtgccgggagggaggcccaa	0.490													6	7	---	---	---	---					
RP11-116N8.1	0	broad.mit.edu	37	14	36491182	36491183	+	RNA	DEL	CT	CT	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:36491182_36491183delCT	ENST00000550089.1	+	0	417																											TAGAAGGCTCCTCATGGTCTGG	0.416													2	4	---	---	---	---					
CTD-2058B24.2	0	broad.mit.edu	37	14	38562379	38562379	+	RNA	DEL	A	A	-	rs78462990		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:38562379delA	ENST00000554687.1	-	0	200																											ggactgaaagaaaaaaacaca	0.473													7	6	---	---	---	---					
CTD-2058B24.2	0	broad.mit.edu	37	14	38637945	38637946	+	RNA	INS	-	-	AC	rs138662479	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:38637945_38637946insAC	ENST00000554687.1	-	0	140																											TCTTACCACGAacacacacaca	0.416													5	8	---	---	---	---					
RP11-305B6.3	0	broad.mit.edu	37	14	44636666	44636669	+	RNA	DEL	ACAC	ACAC	-	rs112819465		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:44636666_44636669delACAC	ENST00000553827.1	-	0	69																											acacagacttacacacacacacac	0.368													6	9	---	---	---	---					
LINC00871	100506412	broad.mit.edu	37	14	46607102	46607106	+	RNA	DEL	CAGTG	CAGTG	-	rs3037572		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:46607102_46607106delCAGTG	ENST00000556886.1	+	0	58					NR_102701.1																						caaatagtctcagtgctgtataagt	0.351													4	5	---	---	---	---					
LINC00871	100506412	broad.mit.edu	37	14	46864142	46864143	+	RNA	INS	-	-	A	rs71448113		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:46864142_46864143insA	ENST00000556886.1	+	0	232					NR_102701.1																						ttacatctcagaaaaaaaaaaa	0.322													3	2	---	---	---	---					
RP11-1033H12.1	0	broad.mit.edu	37	14	52580395	52580398	+	RNA	DEL	GAAG	GAAG	-	rs28437721		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:52580395_52580398delGAAG	ENST00000555852.1	-	0	149																											aagaaaggaagaaggaaggaagga	0.368													4	8	---	---	---	---					
RP11-1033H12.1	0	broad.mit.edu	37	14	52580498	52580499	+	RNA	INS	-	-	AAAAGAAAAGAA	rs144025427	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:52580498_52580499insAAAAGAAAAGAA	ENST00000555852.1	-	0	149																											aagaaggaaagaaaagaaaaga	0.371													3	4	---	---	---	---					
LOC101927690	101927690	broad.mit.edu	37	14	56987772	56987773	+	RNA	DEL	GT	GT	-	rs60583151		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:56987772_56987773delGT	ENST00000557246.1	+	0	187																											TCTTAAAAGAgtgtgtgtgtgt	0.421													2	4	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57341957	57341958	+	RNA	INS	-	-	TTCC	rs3043326	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:57341957_57341958insTTCC	ENST00000534909.2	+	0	287				OTX2-AS1_ENST00000554428.1_RNA|OTX2-AS1_ENST00000554358.1_RNA|OTX2-AS1_ENST00000554725.1_RNA	NR_029385.1																						ctctttctttattccttccttc	0.455													3	3	---	---	---	---					
OTX2-AS1	100309464	broad.mit.edu	37	14	57370158	57370159	+	RNA	DEL	AC	AC	-	rs67302262		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:57370158_57370159delAC	ENST00000534909.2	+	0	474				OTX2-AS1_ENST00000554428.1_RNA|OTX2-AS1_ENST00000554358.1_RNA|OTX2-AS1_ENST00000554725.1_RNA	NR_029385.1																						AGACGGGAAGacacacacacac	0.356													6	11	---	---	---	---					
LOC100128233	100128233	broad.mit.edu	37	14	65679781	65679782	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:65679781_65679782insT	ENST00000531609.1	-	0	1270_1271					NR_103769.1																						agaggtgtggggaggagaactt	0.396													2	4	---	---	---	---					
LOC100128233	100128233	broad.mit.edu	37	14	65685934	65685934	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:65685934delT	ENST00000531609.1	-	0	129					NR_103769.1																						TCTGGCTCTAttttttttttt	0.418													5	7	---	---	---	---					
RP11-187O7.3	0	broad.mit.edu	37	14	77036281	77036281	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:77036281delT	ENST00000554926.1	-	0	310																											TCACAttatcttttttttttt	0.363													2	4	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82217714	82217714	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:82217714delG	ENST00000554814.1	+	0	94																											cacaaactgtggtcactgtgt	0.463													4	6	---	---	---	---					
RP11-666E17.1	0	broad.mit.edu	37	14	82437286	82437287	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:82437286_82437287insA	ENST00000554814.1	+	0	315																											TTCTCCCTGCCATCTACATTTC	0.376													5	6	---	---	---	---					
RP11-33N16.3	0	broad.mit.edu	37	14	90122780	90122781	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:90122780_90122781insT	ENST00000555070.1	-	0	170																											gtccaaatgtatttatccctgg	0.446													8	3	---	---	---	---					
CHORDC2P	317775	broad.mit.edu	37	14	90203668	90203668	+	RNA	DEL	C	C	-	rs67505159		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:90203668delC	ENST00000555070.1	-	0	170																											CTCTTTCTTTCtttttttttt	0.368													2	4	---	---	---	---					
RP11-472N19.3	0	broad.mit.edu	37	14	92728340	92728341	+	RNA	INS	-	-	ACAC	rs10651398	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:92728340_92728341insACAC	ENST00000553537.1	-	0	134																											GCACAGGCTAAacacacacaca	0.401													3	5	---	---	---	---					
RP11-638I2.4	0	broad.mit.edu	37	14	100694341	100694342	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr14:100694341_100694342insA	ENST00000554537.1	-	0	85																											gacaccatctcaaaaaaaaaac	0.480													2	4	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20607010	20607010	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:20607010delC	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GACATTCATGCCTTTCAGCCT	0.398													13	8	---	---	---	---					
HERC2P3	283755	broad.mit.edu	37	15	20607798	20607798	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:20607798delT	ENST00000428453.1	-	0	4041																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						tggtaaaatatacttaatata	0.234													3	4	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22329985	22329986	+	RNA	INS	-	-	A	rs111577781	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:22329985_22329986insA	ENST00000558896.1	+	0	194																											TTACTGTCATTAAAAAAAAAAT	0.297													5	10	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22334587	22334588	+	RNA	INS	-	-	AA	rs71117423		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:22334587_22334588insAA	ENST00000558896.1	+	0	583																											cggtctccaagaaaaaaaaaaa	0.376													2	4	---	---	---	---					
RP11-580I1.2	0	broad.mit.edu	37	15	24511679	24511680	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:24511679_24511680insT	ENST00000566676.1	+	0	54																											tgattttttggtttttgcttaa	0.307													2	4	---	---	---	---					
RP11-2C7.1	0	broad.mit.edu	37	15	26119999	26120000	+	RNA	DEL	GA	GA	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:26119999_26120000delGA	ENST00000557558.1	+	0	225																											ATATAATCATGAGAGAGAGAGA	0.386													2	4	---	---	---	---					
AC009878.2	0	broad.mit.edu	37	15	26659983	26659983	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:26659983delG	ENST00000451579.1	+	0	173																											aatggataaagaaaatgtggt	0.373													6	1	---	---	---	---					
RP11-111A22.1	0	broad.mit.edu	37	15	40803771	40803772	+	RNA	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:40803771_40803772insG	ENST00000561460.1	+	0	280				RP11-111A22.1_ENST00000561039.1_RNA																							CGAGGCGGGCTGGGGGCGTCCT	0.713													2	4	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48179919	48179920	+	RNA	DEL	GC	GC	-	rs150192370	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:48179919_48179920delGC	ENST00000560900.1	+	0	195																											acatgcacgtgcacacacacac	0.455													2	4	---	---	---	---					
RP11-208K4.1	0	broad.mit.edu	37	15	48202630	48202630	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:48202630delC	ENST00000560900.1	+	0	195																											AGGGACTGATCTACCCCCTTA	0.378													3	3	---	---	---	---					
RP11-1129I3.1	0	broad.mit.edu	37	15	56847733	56847734	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:56847733_56847734insA	ENST00000562300.1	-	0	439																											ccccagaaaccaccattcttct	0.406													4	3	---	---	---	---					
RP11-507B12.2	0	broad.mit.edu	37	15	61745292	61745293	+	RNA	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:61745292_61745293insC	ENST00000559783.1	-	0	186																											cctcccattctcccccatcaag	0.426													2	4	---	---	---	---					
ISLR	3671	broad.mit.edu	37	15	74467667	74467667	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:74467667delC	ENST00000249842.3	+	2	825	c.468delC	c.(466-468)aafs	p.N156fs	RP11-665J16.1_ENST00000561647.1_RNA|ISLR_ENST00000395118.1_Frame_Shift_Del_p.N156fs	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	156					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						TCAACCACAACCGCTTGCACA	0.627													34	82	---	---	---	---					
SIN3A	25942	broad.mit.edu	37	15	75684893	75684893	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:75684893delG	ENST00000394947.3	-	15	2855	c.2541delC	c.(2539-2541)gcfs	p.A847fs	SIN3A_ENST00000360439.4_Frame_Shift_Del_p.A847fs|SIN3A_ENST00000394949.4_Frame_Shift_Del_p.A847fs	NM_001145358.1	NP_001138830.1	Q96ST3	SIN3A_HUMAN	SIN3 transcription regulator family member A	847	Interaction with NCOR1 (By similarity).				blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	63						CTGCCCCTGTGGCTTCATCTA	0.438													52	120	---	---	---	---					
RP11-24M17.5	0	broad.mit.edu	37	15	76074553	76074553	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:76074553delC	ENST00000395215.3	+	0	692																											AGGAAGATGACCCCAGGTGGC	0.552													12	13	---	---	---	---					
RP11-648K4.2	0	broad.mit.edu	37	15	88234187	88234187	+	RNA	DEL	A	A	-	rs76536533		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:88234187delA	ENST00000560439.1	-	0	80																											ctgctaatttaaaaaaaaaaa	0.478													2	4	---	---	---	---					
RP11-429B14.1	0	broad.mit.edu	37	15	90109351	90109351	+	RNA	DEL	G	G	-	rs11636151		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:90109351delG	ENST00000559041.1	+	0	47																											CTTGTTTTTTGTTTTTTTTTT	0.373													6	2	---	---	---	---					
LOC101926928	101926928	broad.mit.edu	37	15	92011694	92011695	+	RNA	INS	-	-	ACACACACAC	rs72212726		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:92011694_92011695insACACACACAC	ENST00000554333.1	+	0	295																											acaataggaagacacacacaca	0.347													2	4	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93540529	93540530	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:93540529_93540530insG	ENST00000394196.4	+	30	4849_4850	c.3781_3782insG	c.(3781-3783)gggfs	p.G1261fs	CHD2_ENST00000557381.1_Frame_Shift_Ins_p.G1261fs	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1261					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			TGATGTAGAGTGGGGGGTGGAA	0.411													7	229	---	---	---	---					
LINC01581	101927112	broad.mit.edu	37	15	94455138	94455145	+	RNA	DEL	TTCCTTCC	TTCCTTCC	-	rs145591452		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:94455138_94455145delTTCCTTCC	ENST00000558874.1	-	0	2257				CTD-2643K12.2_ENST00000555364.1_lincRNA																							Gcttcctgttttccttccttccttcctt	0.322													3	5	---	---	---	---					
LINC01581	101927112	broad.mit.edu	37	15	94502446	94502446	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:94502446delT	ENST00000558874.1	-	0	2014				CTD-2643K12.2_ENST00000555364.1_lincRNA																							ttgaaaactcttttttttcag	0.249													2	4	---	---	---	---					
NR2F2-AS1	644192	broad.mit.edu	37	15	96773569	96773569	+	RNA	DEL	A	A	-	rs141652761		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:96773569delA	ENST00000560800.1	-	0	220																											CTTCTGCAGGAAAAAAAAAAA	0.284													4	2	---	---	---	---					
OR4F13P	390651	broad.mit.edu	37	15	102384551	102384552	+	RNA	INS	-	-	A	rs11438899	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr15:102384551_102384552insA	ENST00000560066.1	+	0	211					NR_046417.1																						TAATAAAAAAGAAAAAAAAAGC	0.302													3	2	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5774025	5774026	+	RNA	INS	-	-	G	rs34791502	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:5774025_5774026insG	ENST00000569895.1	+	0	403																											ATGTTAGCAAACCATTTGTGTG	0.446													6	1	---	---	---	---					
EMP2	2013	broad.mit.edu	37	16	10626928	10626930	+	In_Frame_Del	DEL	GCC	GCC	-	rs147528512		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:10626928_10626930delGCC	ENST00000359543.3	-	5	545_547	c.336_338delGGC	c.(334-339)gcc>gc	p.AA112del	EMP2_ENST00000536829.1_In_Frame_Del_p.AA112del	NM_001424.4	NP_001415.1	P54851	EMP2_HUMAN	epithelial membrane protein 2	112					cell proliferation	integral to membrane				NS(1)|endometrium(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	6						ATAAATGGAGGCCGCAATCATGA	0.507													28	32	---	---	---	---					
SHISA9	729993	broad.mit.edu	37	16	13328991	13328992	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:13328991_13328992insG	ENST00000558583.1	+	5	1445_1446	c.1123_1124insG	c.(1123-1125)ggcfs	p.G375fs	SHISA9_ENST00000424107.3_Frame_Shift_Ins_p.G334fs	NM_001145204.2	NP_001138676.2	B4DS77	SHSA9_HUMAN	shisa family member 9	334					regulation of short-term neuronal synaptic plasticity	cell junction|dendritic spine membrane|ionotropic glutamate receptor complex|synapse				breast(1)|endometrium(2)|kidney(1)|lung(2)|prostate(1)|skin(2)	9						GGACGAGCCCCGGGCCTTCAGC	0.609													35	11	---	---	---	---					
U91319.1	0	broad.mit.edu	37	16	13541736	13541736	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:13541736delT	ENST00000571619.1	+	0	420																											GCAACAAAAATTATTGCATGC	0.388													2	4	---	---	---	---					
U91319.1	0	broad.mit.edu	37	16	13559983	13559984	+	RNA	DEL	TC	TC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:13559983_13559984delTC	ENST00000571619.1	+	0	420																											aatgttatgttctgctggccta	0.470													2	4	---	---	---	---					
CTA-481E9.3	0	broad.mit.edu	37	16	18221295	18221296	+	RNA	DEL	CA	CA	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:18221295_18221296delCA	ENST00000563866.1	-	0	48				CTA-481E9.4_ENST00000567304.1_lincRNA																							TACACAATGTcacacacacaca	0.396													2	4	---	---	---	---					
DNAH3	55567	broad.mit.edu	37	16	21063027	21063028	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:21063027_21063028insG	ENST00000261383.3	-	29	4200_4201	c.4201_4202insC	c.(4201-4203)gctfs	p.A1401fs	DNAH3_ENST00000415178.1_Frame_Shift_Ins_p.A1401fs	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1401	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GATCACCAGCCGGGGGGAGTTT	0.569													11	279	---	---	---	---					
HERC2P4	100289574	broad.mit.edu	37	16	32116145	32116146	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:32116145_32116146insT	ENST00000564145.1	-	0	456																											cgcccagttaattttttgtatt	0.510													3	4	---	---	---	---					
HERC2P4	100289574	broad.mit.edu	37	16	32152597	32152597	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:32152597delA	ENST00000564145.1	-	0	65																											TAAGGCACATAATGAGCAATT	0.318													3	4	---	---	---	---					
RP11-481J2.2	0	broad.mit.edu	37	16	58460877	58460878	+	RNA	DEL	AG	AG	-	rs79170352		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:58460877_58460878delAG	ENST00000567448.1	+	0	25																											aaaaaaaaaaagaaaagaaaag	0.470													7	2	---	---	---	---					
LOC101927580	101927580	broad.mit.edu	37	16	59948472	59948473	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:59948472_59948473insA	ENST00000568279.1	+	0	173																											ATGGAACCATGAAAAAAAAAAA	0.356													3	3	---	---	---	---					
RP11-354I13.1	0	broad.mit.edu	37	16	60553254	60553255	+	RNA	INS	-	-	A	rs35886041		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:60553254_60553255insA	ENST00000567862.1	-	0	313																											caagtattaccaaaaaaaaaaa	0.312													3	3	---	---	---	---					
LINC00922	283867	broad.mit.edu	37	16	65491697	65491698	+	RNA	INS	-	-	TGTG	rs141361593	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:65491697_65491698insTGTG	ENST00000569736.1	-	0	217					NR_027755.1																						gtatatgtgtatgtgtgtgtgt	0.376													5	7	---	---	---	---					
LINC00922	283867	broad.mit.edu	37	16	65499623	65499624	+	RNA	DEL	GT	GT	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:65499623_65499624delGT	ENST00000569736.1	-	0	217					NR_027755.1																						atatacatacgtgtgtgtatat	0.302													6	13	---	---	---	---					
LINC00922	283867	broad.mit.edu	37	16	65526176	65526185	+	RNA	DEL	ACACACACAA	ACACACACAA	-	rs72782406		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:65526176_65526185delACACACACAA	ENST00000569736.1	-	0	217					NR_027755.1																						acacacacacacacacacaAAACAACAACC	0.405													4	4	---	---	---	---					
RP11-351A20.1	0	broad.mit.edu	37	16	65673845	65673845	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:65673845delT	ENST00000563811.1	+	0	167																											CACTAAAATCttttttttttt	0.408													3	5	---	---	---	---					
LINC01572	101927957	broad.mit.edu	37	16	72502146	72502146	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:72502146delT	ENST00000561611.2	-	0	221																											TGTATATATGTTTATGTATTT	0.289													2	4	---	---	---	---					
CTD-2336H13.2	0	broad.mit.edu	37	16	76943531	76943532	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:76943531_76943532insA	ENST00000567777.1	+	0	138																											gatctgctaccaaggtcattca	0.510													6	3	---	---	---	---					
LINC01229	101928248	broad.mit.edu	37	16	79766906	79766906	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:79766906delC	ENST00000561510.1	+	0	361																											CAGAACATGACCCAAAAGCAA	0.418													5	9	---	---	---	---					
RP11-148M9.1	0	broad.mit.edu	37	16	80075555	80075555	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:80075555delC	ENST00000565531.1	+	0	133																											GAGAAATTGGCCATTACTGAA	0.383													3	5	---	---	---	---					
RP11-525K10.1	0	broad.mit.edu	37	16	80159829	80159829	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:80159829delC	ENST00000567851.1	+	0	405																											TCGGCATGTTCCCAGAGAGGA	0.577													4	4	---	---	---	---					
LOC102724084	102724084	broad.mit.edu	37	16	80237290	80237291	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr16:80237290_80237291insA	ENST00000565050.1	-	0	598				RP11-525K10.3_ENST00000568776.1_RNA																							CTTTAGGTATGAAAAAAAATAA	0.356													2	4	---	---	---	---					
CTD-2309O5.3	0	broad.mit.edu	37	17	3078128	3078129	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:3078128_3078129insA	ENST00000572821.1	-	0	60																											aatggatacacaaaaaaataaa	0.337													2	4	---	---	---	---					
ALOX12P2	245	broad.mit.edu	37	17	6798388	6798390	+	RNA	DEL	TCT	TCT	-	rs139475307		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:6798388_6798390delTCT	ENST00000574727.1	+	0	814																				endometrium(1)	1						GCTTCCTTGATCTTCTTGCACTC	0.438													19	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7577156	7577156	+	Splice_Site	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:7577156delC	ENST00000420246.2	-	8	915		c.e8-1		TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000455263.2_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(25)|p.0?(8)|p.E258fs*71(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TAGATTACCACTACTCAGGAT	0.512		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			41	1	---	---	---	---					
MYHAS	100128560	broad.mit.edu	37	17	10385745	10385745	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:10385745delA	ENST00000587182.1	+	0	155				CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA																							gtttctctccagaaaatggag	0.358													8	9	---	---	---	---					
COX10-AS1	100874058	broad.mit.edu	37	17	13821467	13821468	+	RNA	DEL	AC	AC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:13821467_13821468delAC	ENST00000602743.1	-	0	224																											ACATATAGATacacacacacac	0.327													2	4	---	---	---	---					
AC005863.2	0	broad.mit.edu	37	17	14773021	14773023	+	RNA	DEL	AAA	AAA	-	rs35413476		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:14773021_14773023delAAA	ENST00000445035.2	+	0	659																											ttaggcgattaaaaaaaaaaaaa	0.340													6	1	---	---	---	---					
KRT16P6	353194	broad.mit.edu	37	17	16724579	16724580	+	RNA	DEL	AT	AT	-	rs4034463		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:16724579_16724580delAT	ENST00000417510.1	-	0	609																											GAATAAGAAGATATATTGGCCC	0.490													5	7	---	---	---	---					
KCNJ12	3768	broad.mit.edu	37	17	21319123	21319124	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:21319123_21319124insT	ENST00000583088.1	+	3	1364_1365	c.469_470insT	c.(469-471)ggcfs	p.G157fs	KCNJ12_ENST00000331718.5_Frame_Shift_Ins_p.G157fs	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GGAGTGCCCGGTGGCCGTCTTC	0.614										Prostate(3;0.18)			16	33	---	---	---	---					
RP11-296K13.4	0	broad.mit.edu	37	17	27694972	27694972	+	RNA	DEL	A	A	-	rs72362583		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:27694972delA	ENST00000584958.1	+	0	39																											acaaagcaagaAAAAAAAAGA	0.443													3	4	---	---	---	---					
YWHAEP7	284100	broad.mit.edu	37	17	36230364	36230365	+	RNA	DEL	AT	AT	-	rs11263769	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:36230364_36230365delAT	ENST00000590732.1	-	0	218					NR_024178.1																						acacacacacatacacacacac	0.391													4	7	---	---	---	---					
RP11-387H17.4	0	broad.mit.edu	37	17	38094948	38094949	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:38094948_38094949insA	ENST00000582263.1	+	0	368																											gaccctctctcaaaaaaaaaGG	0.550													4	3	---	---	---	---					
RP5-1110E20.1	0	broad.mit.edu	37	17	39016116	39016117	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:39016116_39016117insA	ENST00000579136.1	+	0	61																											taataagacacaaatattgagt	0.416													4	7	---	---	---	---					
LINC00854	100874261	broad.mit.edu	37	17	41372560	41372561	+	RNA	DEL	TC	TC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:41372560_41372561delTC	ENST00000427995.1	-	0	578				LINC00854_ENST00000595400.1_RNA|LINC00854_ENST00000593624.1_RNA																							ATCTCTAAAGTCTCTTCCAATT	0.505													4	8	---	---	---	---					
GPATCH8	23131	broad.mit.edu	37	17	42475936	42475937	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:42475936_42475937insC	ENST00000434000.1	-	9	3556_3557	c.3274_3275insG	c.(3274-3276)agafs	p.R1092fs	GPATCH8_ENST00000591680.1_Frame_Shift_Ins_p.R1170fs			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	1170						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TTCTTGCTCTTCCCCCCTTTCC	0.525													8	409	---	---	---	---					
LINC01482	101928104	broad.mit.edu	37	17	66624631	66624632	+	RNA	DEL	TG	TG	-	rs78155060		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:66624631_66624632delTG	ENST00000585484.1	+	0	33																											tcctcaaaactgtttatctttc	0.421													9	5	---	---	---	---					
CTD-2378E21.1	0	broad.mit.edu	37	17	68345261	68345262	+	RNA	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:68345261_68345262insG	ENST00000592809.1	-	0	101																											ACAATACAAAAGGGGGATTTGA	0.366													2	4	---	---	---	---					
CASC17	101928165	broad.mit.edu	37	17	69190605	69190614	+	RNA	DEL	ACACACACAC	ACACACACAC	-	rs36227585		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:69190605_69190614delACACACACAC	ENST00000569074.1	-	0	74																											atacacacagacacacacacacacacacac	0.419													5	11	---	---	---	---					
CARD14	79092	broad.mit.edu	37	17	78156517	78156517	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr17:78156517delA	ENST00000573882.1	+	5	813	c.277delA	c.(277-279)agfs	p.K93fs	CARD14_ENST00000570421.1_Frame_Shift_Del_p.K93fs|CARD14_ENST00000344227.2_Frame_Shift_Del_p.K93fs			Q9BXL6	CAR14_HUMAN	caspase recruitment domain family, member 14	93	CARD.				activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(5)|prostate(1)|skin(1)	23	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			GGAGAGCCTGAAGTTCCACAA	0.577													34	56	---	---	---	---					
LINC00470	56651	broad.mit.edu	37	18	1302360	1302360	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:1302360delC	ENST00000412816.3	-	0	307																				pancreas(1)	1						ccactgttttccgtgttcacc	0.433													7	2	---	---	---	---					
RP11-449D8.5	0	broad.mit.edu	37	18	22360160	22360160	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:22360160delG	ENST00000582650.1	+	0	235																											attcccttcTGTTGGCCTACA	0.443													9	3	---	---	---	---					
RP11-739N10.1	0	broad.mit.edu	37	18	24941263	24941264	+	RNA	INS	-	-	T	rs146813134	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:24941263_24941264insT	ENST00000584546.1	-	0	447																											GTGACTTGATATATGAGACCAG	0.441													11	1	---	---	---	---					
RP11-739N10.1	0	broad.mit.edu	37	18	24967246	24967247	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:24967246_24967247insA	ENST00000584546.1	-	0	447																											TGCAACATAGCAAAACCAGCCC	0.337													5	2	---	---	---	---					
RP11-739N10.1	0	broad.mit.edu	37	18	25147357	25147358	+	RNA	DEL	TG	TG	-	rs36207939	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:25147357_25147358delTG	ENST00000584546.1	-	0	260																											tgtgtatatatgtgtgtgtgtg	0.351													7	4	---	---	---	---					
CTD-2515C13.2	0	broad.mit.edu	37	18	26940797	26940798	+	RNA	INS	-	-	TAA	rs143557809	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:26940797_26940798insTAA	ENST00000577674.1	-	0	80																											ggttactgggttaatttttgat	0.436													8	3	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37226917	37226918	+	RNA	INS	-	-	C	rs141218137	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:37226917_37226918insC	ENST00000591629.1	-	0	282					NR_024391.1																						tgcacctgccgcccccccaaca	0.446													3	3	---	---	---	---					
LINC00669	647946	broad.mit.edu	37	18	37277690	37277690	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:37277690delA	ENST00000591629.1	-	0	282					NR_024391.1																						ctcaaaaattaaaaaaaaaaa	0.453													2	4	---	---	---	---					
LINC01477	101927900	broad.mit.edu	37	18	37668748	37668748	+	RNA	DEL	T	T	-	rs150415663		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:37668748delT	ENST00000566101.1	+	0	1004																											GAAAAAGACATTTTTTTTTTT	0.328													3	5	---	---	---	---					
KC6	641516	broad.mit.edu	37	18	39083911	39083912	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:39083911_39083912insA	ENST00000592302.1	-	0	350					NR_002838.1																						atgagagatccatccccataac	0.465													5	1	---	---	---	---					
LINC00907	284260	broad.mit.edu	37	18	39943643	39943644	+	RNA	DEL	AC	AC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:39943643_39943644delAC	ENST00000593234.1	+	0	713					NR_046456.1																						GTTGTGATTGACACACACACAC	0.450													2	4	---	---	---	---					
RP11-157P23.2	0	broad.mit.edu	37	18	45055715	45055722	+	RNA	DEL	TGTGTGTG	TGTGTGTG	-	rs10616874		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:45055715_45055722delTGTGTGTG	ENST00000565127.1	+	0	275																											CCTTGGCATAtgtgtgtgtgtgtgtgtg	0.394													3	6	---	---	---	---					
DCC	1630	broad.mit.edu	37	18	50705443	50705443	+	Frame_Shift_Del	DEL	G	G	-	rs151271207		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:50705443delG	ENST00000442544.2	+	9	2146	c.1530delG	c.(1528-1530)ccfs	p.P510fs	DCC_ENST00000581580.1_Frame_Shift_Del_p.P165fs|DCC_ENST00000412726.1_Frame_Shift_Del_p.P358fs	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	510	Fibronectin type-III 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		AATGGGGACCGGGAGAGAGTT	0.473													26	73	---	---	---	---					
LOC642484	642484	broad.mit.edu	37	18	53843055	53843056	+	RNA	DEL	TG	TG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:53843055_53843056delTG	ENST00000382897.2	-	0	698																											TAACAAATTATGTGTAACTTGG	0.332													7	0	---	---	---	---					
LOC643542	643542	broad.mit.edu	37	18	65306765	65306765	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:65306765delT	ENST00000583687.1	+	0	204					NR_033921.1																						tctgtcttcattttttttcct	0.338													4	6	---	---	---	---					
LOC101927651	101927651	broad.mit.edu	37	18	74341186	74341187	+	RNA	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:74341186_74341187insT	ENST00000582231.1	-	0	521																											tgatgggattgtttttttcttg	0.337													2	4	---	---	---	---					
RP11-176N18.2	0	broad.mit.edu	37	18	75182521	75182521	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:75182521delT	ENST00000583629.1	+	0	406																											CCAAAGAAACTTTTTTTTTTT	0.313													3	6	---	---	---	---					
RP11-176N18.2	0	broad.mit.edu	37	18	75202732	75202732	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr18:75202732delA	ENST00000583629.1	+	0	406																											TGACTTCCACAAAAACACTAC	0.403													3	5	---	---	---	---					
PCSK4	54760	broad.mit.edu	37	19	1486857	1486857	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:1486857delG	ENST00000300954.5	-	8	1124	c.1063delC	c.(1063-1065)agfs	p.Q355fs		NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	355	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity			cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCACGATCTGGGGGTCGGTG	0.706													13	0	---	---	---	---					
LOC101928844	101928844	broad.mit.edu	37	19	5851762	5851763	+	RNA	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:5851762_5851763insG	ENST00000589276.1	+	0	302																											GTGGGTCCCACGGGGGCCCCAT	0.495													2	4	---	---	---	---					
LINC00661	126536	broad.mit.edu	37	19	16127497	16127503	+	RNA	DEL	TGCCCTT	TGCCCTT	-	rs111815826	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:16127497_16127503delTGCCCTT	ENST00000549354.1	+	0	156					NR_026828.1																						ctctgccctctgccctttgccctATGT	0.614													4	6	---	---	---	---					
TM6SF2	53345	broad.mit.edu	37	19	19381037	19381037	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:19381037delC	ENST00000389363.4	-	4	418	c.346delG	c.(346-348)atfs	p.D116fs	TM6SF2_ENST00000586107.1_5'UTR|AC138430.4_ENST00000586064.2_RNA	NM_001001524.2	NP_001001524.2	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	116						integral to membrane				breast(2)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14			Epithelial(12;0.0151)			ACAGTGCCATCCCAGTAGCAG	0.652													18	119	---	---	---	---					
AC007204.2	0	broad.mit.edu	37	19	20049024	20049025	+	RNA	INS	-	-	T	rs72497904		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:20049024_20049025insT	ENST00000592245.1	+	0	72																											CCTTATGCAGGTTTTTTTTTTT	0.327													4	3	---	---	---	---					
ZNF99	7652	broad.mit.edu	37	19	22940021	22940021	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:22940021delC	ENST00000397104.3	-	6	2309	c.2310delG	c.(2308-2310)ggfs	p.G770fs						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ATGGTTTCTTCCCAGTATAAA	0.368													105	51	---	---	---	---					
CTD-2291D10.3	0	broad.mit.edu	37	19	23253621	23253621	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:23253621delC	ENST00000599269.1	-	0	156																											ATGGGGCCTGCCGGGCCACAC	0.701													6	0	---	---	---	---					
CTC-360P9.4	0	broad.mit.edu	37	19	32500159	32500159	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:32500159delA	ENST00000590053.1	-	0	112																											ATTTCTTTTTAAATTATATTG	0.458													2	4	---	---	---	---					
CHST8	64377	broad.mit.edu	37	19	34180279	34180280	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:34180279_34180280insC	ENST00000262622.3	+	2	870_871	c.112_113insC	c.(112-114)cccfs	p.P38fs	CHST8_ENST00000438847.2_Frame_Shift_Ins_p.P38fs|CHST8_ENST00000604556.1_Frame_Shift_Ins_p.P38fs|CHST8_ENST00000434302.1_Frame_Shift_Ins_p.P38fs	NM_022467.3	NP_071912.2	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8	38					carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity	p.A38T(1)		NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(8)|ovary(1)|prostate(1)|skin(5)	27	Esophageal squamous(110;0.162)					TACGGAGCTCGCCCCCCAGCAG	0.634													7	237	---	---	---	---					
CTC-523E23.11	0	broad.mit.edu	37	19	35347278	35347278	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:35347278delA	ENST00000604749.1	-	0	403																											cctatctcttaaaaaaaaaaa	0.378													2	4	---	---	---	---					
FXYD5	53827	broad.mit.edu	37	19	35657248	35657248	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:35657248delG	ENST00000543307.1	+	8	587	c.507delG	c.(505-507)gtfs	p.V169fs	FXYD5_ENST00000541435.2_Intron|FXYD5_ENST00000423817.3_Intron|FXYD5_ENST00000392217.3_Intron|FXYD5_ENST00000591716.2_Intron|FXYD5_ENST00000342879.3_Intron|FXYD5_ENST00000588699.1_Frame_Shift_Del_p.V169fs|FXYD5_ENST00000392219.2_Intron|FXYD5_ENST00000590686.1_Intron			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	0					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GGGGTTGGGTGGGAAGGACAC	0.532													57	254	---	---	---	---					
FFAR2	2867	broad.mit.edu	37	19	35940788	35940790	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:35940788_35940790delCTG	ENST00000599180.1	+	2	252_254	c.172_174delCTG	c.(172-174)del	p.L62del	FFAR2_ENST00000246549.2_In_Frame_Del_p.L62del|FFAR2_ENST00000601590.1_Intron			O15552	FFAR2_HUMAN	free fatty acid receptor 2	62						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(6)|skin(1)|urinary_tract(1)	22	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CGACCTCCTCCTGCTGCTGCTGC	0.645													9	256	---	---	---	---					
LGALS17A	400696	broad.mit.edu	37	19	40174326	40174326	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:40174326delA	ENST00000412609.1	+	0	549																											GTCCAGCACTAACCCCATGGC	0.498													3	4	---	---	---	---					
PCAT19	100505495	broad.mit.edu	37	19	41978109	41978110	+	RNA	INS	-	-	G	rs58900915		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:41978109_41978110insG	ENST00000588495.1	-	0	1153					NR_040109.1																						aacaatatcacgggggggtgta	0.416													4	5	---	---	---	---					
MEGF8	1954	broad.mit.edu	37	19	42860558	42860559	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:42860558_42860559insT	ENST00000334370.4	+	25	5009_5010	c.4374_4375insT	c.(4372-4377)atttggfs	p.W1459fs	MEGF8_ENST00000251268.6_Frame_Shift_Ins_p.W1526fs	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1526						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				CCTTGTGGATGTTTGGGGGCCT	0.639													15	4	---	---	---	---					
ZNF428	126299	broad.mit.edu	37	19	44111923	44111923	+	Frame_Shift_Del	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:44111923delG	ENST00000300811.3	-	3	859	c.413delC	c.(412-414)cafs	p.P139fs	SRRM5_ENST00000526798.1_Intron|SRRM5_ENST00000607544.1_Intron	NM_182498.3	NP_872304.2	Q96B54	ZN428_HUMAN	zinc finger protein 428	139	Glu-rich.					intracellular	zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	5		Prostate(69;0.0153)				AGCCCGAGGTGGTTCCTCCTC	0.677													45	2	---	---	---	---					
AC007193.6	0	broad.mit.edu	37	19	46620886	46620887	+	RNA	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:46620886_46620887insA	ENST00000597989.1	+	0	16																											acatgcatgtgccatcaagcct	0.510													5	3	---	---	---	---					
AC007193.6	0	broad.mit.edu	37	19	46686795	46686795	+	RNA	DEL	T	T	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:46686795delT	ENST00000597989.1	+	0	122																											ttctGCAGACttttttttttt	0.527													3	6	---	---	---	---					
AC006262.10	0	broad.mit.edu	37	19	46732258	46732259	+	RNA	DEL	TC	TC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:46732258_46732259delTC	ENST00000597337.1	-	0	219_220																											TCTCCTACCTTCTCTCTCTCtc	0.460													3	6	---	---	---	---					
ZIM2-AS1	101929059	broad.mit.edu	37	19	57273993	57273993	+	RNA	DEL	T	T	-	rs11308539		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr19:57273993delT	ENST00000594400.1	+	0	266																											CTCAGGAttcttttttttttt	0.383													3	5	---	---	---	---					
SDCBP2-AS1	100507495	broad.mit.edu	37	20	1332884	1332885	+	RNA	INS	-	-	T	rs145726265		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:1332884_1332885insT	ENST00000446423.1	+	0	109					NR_040048.1																						ccttcctttccttccttccttc	0.515													2	4	---	---	---	---					
RP11-103J8.1	0	broad.mit.edu	37	20	10750557	10750557	+	RNA	DEL	A	A	-	rs147585623	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:10750557delA	ENST00000605292.1	+	0	98																											TTCCTTCCTGAAAGCCAATTA	0.443													2	4	---	---	---	---					
LOC101929413	101929413	broad.mit.edu	37	20	10886298	10886298	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:10886298delA	ENST00000448859.1	-	0	307				RP11-103J8.1_ENST00000605292.1_RNA|RP11-103J8.1_ENST00000603462.1_RNA																							TTGTATCCATAAGCTTTATCC	0.418													2	4	---	---	---	---					
LOC100505664	100505664	broad.mit.edu	37	20	23168858	23168858	+	RNA	DEL	T	T	-	rs41282284	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:23168858delT	ENST00000411595.1	+	0	31																											ATtgtgtgtgtggggggggtt	0.512													3	5	---	---	---	---					
LOC100505664	100505664	broad.mit.edu	37	20	23169268	23169269	+	RNA	DEL	TG	TG	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:23169268_23169269delTG	ENST00000411595.1	+	0	31																											tgtgtgggattgtgtgtgtgtg	0.465													7	4	---	---	---	---					
FAM83C	128876	broad.mit.edu	37	20	33874994	33874995	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:33874994_33874995insG	ENST00000374408.3	-	4	1683_1684	c.1587_1588insC	c.(1585-1590)ccactcfs	p.L530fs		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	530										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGGCCTGAGTTGGGGGTAACCC	0.653													51	80	---	---	---	---					
TOX2	84969	broad.mit.edu	37	20	42635227	42635228	+	Frame_Shift_Ins	INS	-	-	C	rs34581744		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:42635227_42635228insC	ENST00000358131.5	+	3	441_442	c.233_234insC	c.(232-234)accfs	p.T78fs	TOX2_ENST00000341197.3_Frame_Shift_Ins_p.T69fs|TOX2_ENST00000372999.1_Frame_Shift_Ins_p.T27fs|TOX2_ENST00000423191.1_Frame_Shift_Ins_p.T27fs	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	78	Required for transcriptional activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GACTATGAGATCCCCCCGATAA	0.584													7	498	---	---	---	---					
SALL4	57167	broad.mit.edu	37	20	50400982	50400983	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:50400982_50400983insC	ENST00000217086.4	-	4	3094_3095	c.2983_2984insG	c.(2983-2985)tccfs	p.S995fs	SALL4_ENST00000395997.3_Frame_Shift_Ins_p.S558fs|SALL4_ENST00000371539.3_Frame_Shift_Ins_p.S218fs	NM_020436.3	NP_065169.1	Q9UJQ4	SALL4_HUMAN	spalt-like transcription factor 4	995					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(27)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GAGGGTAGGAACCCCCCCACTC	0.559													11	64	---	---	---	---					
APCDD1L-AS1	149773	broad.mit.edu	37	20	57159887	57159888	+	RNA	INS	-	-	CTTC	rs142796198	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr20:57159887_57159888insCTTC	ENST00000427140.1	+	0	943					NR_034147.1																						ctcccttctttcttccttcctt	0.535													18	40	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11031726	11031726	+	RNA	DEL	A	A	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:11031726delA	ENST00000470054.1	-	0	1476									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aacctgctacaagagtctact	0.453													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11062462	11062466	+	RNA	DEL	AATGA	AATGA	-	rs56316659		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:11062462_11062466delAATGA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATATAAAATGAAtgaaatactttgg	0.351													2	4	---	---	---	---					
CHODL-AS1	54075	broad.mit.edu	37	21	19241215	19241216	+	RNA	INS	-	-	A	rs58694067	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:19241215_19241216insA	ENST00000447175.1	-	0	147					NR_024354.1																						ctttagaaattaaaaaaaaaGA	0.386													4	2	---	---	---	---					
AP000233.4	0	broad.mit.edu	37	21	26641771	26641771	+	RNA	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:26641771delC	ENST00000409758.1	-	0	89																											aagaactcaaccccttttaca	0.313													5	1	---	---	---	---					
AP001604.3	0	broad.mit.edu	37	21	28744452	28744453	+	RNA	DEL	GA	GA	-	rs67701905		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:28744452_28744453delGA	ENST00000420186.2	-	0	331				AP001605.4_ENST00000447384.1_lincRNA																							ATGTTTGAGGGAGAAAGCACAG	0.396													6	0	---	---	---	---					
LOC284825	284825	broad.mit.edu	37	21	29441560	29441561	+	RNA	INS	-	-	G	rs140003178	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:29441560_29441561insG	ENST00000426534.1	+	0	124																											TGTATGTATGTGGGGGGGGCTT	0.416													6	5	---	---	---	---					
AF131217.1	0	broad.mit.edu	37	21	29847318	29847319	+	RNA	INS	-	-	G	rs146335554		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:29847318_29847319insG	ENST00000433310.1	-	0	456																											GTGGTTGAGGAGGGGGGGGTGG	0.460													4	9	---	---	---	---					
AP000318.2	0	broad.mit.edu	37	21	35608298	35608298	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:35608298delG	ENST00000427022.1	+	0	311																											CTGGTTGCCAGGTATTCTGCT	0.483													3	4	---	---	---	---					
AP001610.9	0	broad.mit.edu	37	21	42933542	42933543	+	RNA	INS	-	-	CT	rs146524288	by1000genomes	TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr21:42933542_42933543insCT	ENST00000415820.1	-	0	52																											ACTCTGTTGCGCTCTCTCTCTC	0.564													3	4	---	---	---	---					
CRYBB2P1	1416	broad.mit.edu	37	22	25897865	25897866	+	RNA	INS	-	-	T	rs113863666		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:25897865_25897866insT	ENST00000354451.2	+	0	366																											ttgttagagtcttttttttttt	0.396													2	4	---	---	---	---					
LOC102724900	102724900	broad.mit.edu	37	22	27748880	27748880	+	RNA	DEL	G	G	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:27748880delG	ENST00000413244.1	+	0	491																											TGTGAGGTCTGTGAAGAGCGC	0.522													4	2	---	---	---	---					
LL22NC03-86D4.1	0	broad.mit.edu	37	22	34455236	34455237	+	RNA	INS	-	-	A	rs112005579		TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chr22:34455236_34455237insA	ENST00000412218.1	+	0	55																											gcgttaggaataaaaaaaaccc	0.470													4	2	---	---	---	---					
NLGN4X	57502	broad.mit.edu	37	X	5811483	5811484	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:5811483_5811484insT	ENST00000381095.3	-	6	2452_2453	c.1825_1826insA	c.(1825-1827)aacfs	p.N609fs	NLGN4X_ENST00000538097.1_Frame_Shift_Ins_p.N609fs|NLGN4X_ENST00000275857.6_Frame_Shift_Ins_p.N609fs|NLGN4X_ENST00000381093.2_Frame_Shift_Ins_p.N629fs|NLGN4X_ENST00000381092.1_Frame_Shift_Ins_p.N609fs	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	609					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						CTTTGTGGTTGTTGAAACATAC	0.500													18	34	---	---	---	---					
BCOR	54880	broad.mit.edu	37	X	39934292	39934293	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:39934292_39934293insA	ENST00000342274.4	-	4	668_669	c.306_307insT	c.(304-309)cgaggcfs	p.G103fs	BCOR_ENST00000378455.4_Frame_Shift_Ins_p.G103fs|BCOR_ENST00000397354.3_Frame_Shift_Ins_p.G103fs|BCOR_ENST00000378444.4_Frame_Shift_Ins_p.G103fs	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	103					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						GTGGCAGCCTCCCGACCTTTCT	0.564			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						19	34	---	---	---	---					
RP1-154K9.2	0	broad.mit.edu	37	X	42311849	42311850	+	RNA	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:42311849_42311850insG	ENST00000411879.1	+	0	452																											acataacggaagggggggtaga	0.347													2	4	---	---	---	---					
HDAC6	10013	broad.mit.edu	37	X	48676754	48676754	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:48676754delC	ENST00000334136.5	+	22	2300	c.2122delC	c.(2122-2124)ccfs	p.P708fs	HDAC6_ENST00000376619.2_Frame_Shift_Del_p.P708fs|HDAC6_ENST00000444343.2_Frame_Shift_Del_p.P722fs			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	708	Histone deacetylase 2.				aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	ATGGAACGGGCCCCGCATGGG	0.617													46	3	---	---	---	---					
FGD1	2245	broad.mit.edu	37	X	54497147	54497148	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:54497147_54497148insG	ENST00000375135.3	-	3	1260_1261	c.527_528insC	c.(526-528)cctfs	p.P176fs		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	176	Pro-rich.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						TGGGCTCCAGTGGGGGGGGCAT	0.663													4	8	---	---	---	---					
NAP1L2	4674	broad.mit.edu	37	X	72433664	72433666	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:72433664_72433666delTCC	ENST00000373517.3	-	1	1018_1020	c.663_665delGGA	c.(661-666)gac>ga	p.ED221del	NAP1L2_ENST00000536638.1_In_Frame_Del_p.ED79del	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	221	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					CTCAATGTCGtcctcctcctcct	0.424													8	89	---	---	---	---					
TGIF2LX	90316	broad.mit.edu	37	X	89177571	89177571	+	Frame_Shift_Del	DEL	C	C	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:89177571delC	ENST00000561129.2	+	1	617	c.487delC	c.(487-489)cafs	p.P163fs	TGIF2LX_ENST00000283891.5_Frame_Shift_Del_p.P163fs			Q8IUE1	TF2LX_HUMAN	TGFB-induced factor homeobox 2-like, X-linked	163						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(29)|ovary(1)|skin(3)|urinary_tract(1)	40						GTGGCCCTTGCCAAAGGGCCA	0.602													62	9	---	---	---	---					
TRPC5	7224	broad.mit.edu	37	X	111020157	111020159	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-17-Z031-01A-01W-0746-08	TCGA-17-Z031-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6516244a-dfd8-4568-a2d2-7556cbea52b1	691dc2f3-35d7-4b83-a51a-49ed1d4c2a07	g.chrX:111020157_111020159delCTC	ENST00000262839.2	-	11	3222_3224	c.2304_2306delGAG	c.(2302-2307)agc>ag	p.RS768del		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	768					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						AGTGGAAAAGCTCCTTGGATGTT	0.443													9	304	---	---	---	---					
