Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ITGA11	22801	broad.mit.edu	37	15	68620499	68620499	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr15:68620499C>A	ENST00000423218.2	-	16	2098	c.2003G>T	c.(2002-2004)tGc>tTc	p.C668F	ITGA11_ENST00000315757.7_Missense_Mutation_p.C668F			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	668					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity	p.C668F(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	GGCGGCCAGGCAGGTGGCATC	0.577000													6	67					0.000442599	0.000490264	0.058154	1	0
MT1L	4500	broad.mit.edu	37	16	56652609	56652609	+	RNA	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr16:56652609C>T	ENST00000565768.1	+	0	290					NR_001447.2				metallothionein 1L (gene/pseudogene)																		GACAGCCCTGCTCCCAGATGT	0.512000													3	78					0	0	0.115264	0	0
SIRPB1	10326	broad.mit.edu	37	20	1552414	1552414	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr20:1552414G>C	ENST00000381605.4	-	3	767	c.703C>G	c.(703-705)Cag>Gag	p.Q235E	SIRPB1_ENST00000262929.5_Intron|SIRPB1_ENST00000381603.3_Intron|RP4-576H24.4_ENST00000564763.1_Intron	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	235	Ig-like C1-type 1.				cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding			central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						GGGTCCCCCTGCAAGGTGATG	0.602000													81	133					0	0	0.139131	0	0
RNF214	257160	broad.mit.edu	37	11	117153155	117153155	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr11:117153155C>A	ENST00000530849.1	+	11	1293	c.1283C>A	c.(1282-1284)aCa>aAa	p.T428K	RNF214_ENST00000524917.1_3'UTR|RNF214_ENST00000531452.1_Missense_Mutation_p.T583K|RNF214_ENST00000531287.1_Missense_Mutation_p.T428K|RNF214_ENST00000300650.4_Missense_Mutation_p.T583K			Q8ND24	RN214_HUMAN	ring finger protein 214	583							zinc ion binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.88e-05)|Epithelial(105;0.000397)|all cancers(92;0.00258)		CAGATCAAGACAGCACGTACC	0.522000													4	92					0.00909568	0.00992256	0.150653	1	0
SDCCAG3	10807	broad.mit.edu	37	9	139298534	139298534	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr9:139298534A>G	ENST00000298537.7	-	8	1323	c.1112T>C	c.(1111-1113)gTc>gCc	p.V371A	SDCCAG3_ENST00000371725.3_Missense_Mutation_p.V321A|SDCCAG3_ENST00000357365.3_Missense_Mutation_p.V394A|SDCCAG3_ENST00000461693.1_5'UTR	NM_006643.3	NP_006634.3	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	394						cytoplasm				NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)	16		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		ACTGTTCATGACCACCCGGAG	0.627000													4	95					0	0	0.150653	0	0
MSH4	4438	broad.mit.edu	37	1	76363723	76363723	+	Nonsense_Mutation	SNP	T	T	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:76363723T>G	ENST00000263187.3	+	18	2591	c.2487T>G	c.(2485-2487)taT>taG	p.Y829*		NM_002440.3	NP_002431.2	O15457	MSH4_HUMAN	mutS homolog 4	829					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			breast(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	47						CAATTTTGTATACCTACAAAC	0.303000								Mismatch excision repair (MMR)					31	99					0	0	0.183431	0	0
PHF2	5253	broad.mit.edu	37	9	96428051	96428051	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr9:96428051G>A	ENST00000359246.4	+	15	2388	c.2021G>A	c.(2020-2022)cGg>cAg	p.R674Q	PHF2_ENST00000375376.4_Intron	NM_005392.3	NP_005383.3	O75151	PHF2_HUMAN	PHD finger protein 2	674					liver development|negative regulation of chromatin silencing at rDNA|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K9 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;9.11e-28)		AAGCCCGTGCGGGATGAGTAT	0.582000													3	85					0	0	0.115264	0	0
BRWD1	54014	broad.mit.edu	37	21	40608649	40608649	+	Missense_Mutation	SNP	A	A	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr21:40608649A>C	ENST00000342449.3	-	23	2716	c.2638T>G	c.(2638-2640)Tta>Gta	p.L880V	BRWD1_ENST00000333229.2_Missense_Mutation_p.L880V|BRWD1_ENST00000380800.3_Missense_Mutation_p.L880V	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	880					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				GATGTTCTTAAAGGAGGCTGC	0.408000													26	105					0	0	0.116897	0	0
DENND4B	9909	broad.mit.edu	37	1	153915382	153915382	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:153915382C>T	ENST00000361217.4	-	3	960	c.542G>A	c.(541-543)cGg>cAg	p.R181Q		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	181	MABP.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCGGGGCAGCCGGCAGTAAGT	0.642000													3	20					0	0	0.115264	0	0
HERC2	8924	broad.mit.edu	37	15	28386775	28386775	+	Splice_Site	SNP	G	G	A	rs149707599	byFrequency	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr15:28386775G>A	ENST00000261609.7	-	78	11926	c.11816_splice	c.e78-1	p.R3940_splice		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3940					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.R3940*(2)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCATCTGGTCGCCTACAATAC	0.478000													39	183					0	0	0.139131	0	0
PRSS54	221191	broad.mit.edu	37	16	58314362	58314362	+	Silent	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr16:58314362C>T	ENST00000219301.4	-	7	1348	c.954G>A	c.(952-954)agG>agA	p.R318R	PRSS54_ENST00000543437.1_Silent_p.R219R|CCDC113_ENST00000443128.2_3'UTR|PRSS54_ENST00000567164.1_Silent_p.R318R|CCDC113_ENST00000219299.4_3'UTR	NM_001080492.1	NP_001073961.1	Q6PEW0	PRS54_HUMAN	protease, serine, 54	318					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						GCGTGATGGTCCTTCTTTGTC	0.468000													20	107					0	0	0.055883	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													3	30					0	0	0.115264	0	0
MYH2	4620	broad.mit.edu	37	17	10432554	10432554	+	Silent	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr17:10432554G>A	ENST00000245503.5	-	26	3663	c.3279C>T	c.(3277-3279)atC>atT	p.I1093I	CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Silent_p.I1093I|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1093					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCAGATTGCTGATTTCAAACT	0.333000													5	78					0	0	0.184627	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22868967	22868967	+	Splice_Site	SNP	G	G	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr15:22868967G>C	ENST00000283645.4	+	20	2968		c.e20+1		TUBGCP5_ENST00000453949.2_Splice_Site	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5						G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GAGAGAAAAGGTACATGAGAT	0.443000													4	22					0	0	0.150653	0	0
MXRA5	25878	broad.mit.edu	37	X	3238065	3238065	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chrX:3238065C>G	ENST00000217939.6	-	5	5815	c.5661G>C	c.(5659-5661)tgG>tgC	p.W1887C		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1887	Ig-like C2-type 3.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AAACCTTTGTCCAAGTAACGA	0.388000													3	106					0	0	0.115264	0	0
FYB	2533	broad.mit.edu	37	5	39202820	39202820	+	Silent	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr5:39202820C>T	ENST00000351578.6	-	2	433	c.243G>A	c.(241-243)ccG>ccA	p.P81P	FYB_ENST00000540520.1_Silent_p.P91P|FYB_ENST00000515010.1_Silent_p.P81P|FYB_ENST00000505428.1_Silent_p.P81P|FYB_ENST00000512982.1_Silent_p.P81P	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	81					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			GCTTTAGAAACGGGGGCTTGG	0.552000													9	108					0	0	0.069234	0	0
SYT16	83851	broad.mit.edu	37	14	62551035	62551035	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr14:62551035C>T	ENST00000430451.2	+	5	1753	c.1556C>T	c.(1555-1557)aCg>aTg	p.T519M		NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	519	C2 2.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		AATGCCACAACGGGGCGATTA	0.537000													35	107					0	0	0.183431	0	0
TRBV7-6	28592	broad.mit.edu	37	7	142139456	142139456	+	RNA	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr7:142139456C>T	ENST00000390374.3	-	0	213																											TGCCCCAGGGCCTGTCGGTAC	0.517000													5	216					0	0	0.058154	0	0
CLU	1191	broad.mit.edu	37	8	27472262	27472262	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr8:27472262G>A	ENST00000560366.1	-	1	65	c.37C>T	c.(37-39)Cgc>Tgc	p.R13C	CLU_ENST00000316403.10_5'UTR	NM_001831.3	NP_001822.3	P10909	CLUS_HUMAN	clusterin	0					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		CTCTGCTCGCGCACACACCCC	0.662000											OREG0018671	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	99					0	0	0.150653	0	0
ZBTB21	49854	broad.mit.edu	37	21	43412010	43412010	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr21:43412010G>C	ENST00000310826.5	-	3	2378	c.2195C>G	c.(2194-2196)tCt>tGt	p.S732C	ZBTB21_ENST00000398511.3_Missense_Mutation_p.S732C|ZBTB21_ENST00000465968.1_Intron|ZBTB21_ENST00000398499.1_Missense_Mutation_p.S732C|ZBTB21_ENST00000398505.3_Intron	NM_001098402.1	NP_001091872.1			zinc finger and BTB domain containing 21									p.S732C(1)									TAGGAGAGAAGAGAGCTTAGC	0.522000													79	386					0	0	0.139131	0	0
NEK1	4750	broad.mit.edu	37	4	170498225	170498225	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr4:170498225T>C	ENST00000439128.2	-	11	1514	c.874A>G	c.(874-876)Aga>Gga	p.R292G	NEK1_ENST00000512193.1_Missense_Mutation_p.R292G|NEK1_ENST00000510533.1_Missense_Mutation_p.R292G|NEK1_ENST00000511633.1_Missense_Mutation_p.R292G|NEK1_ENST00000507142.1_Missense_Mutation_p.R292G	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	292					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		GAAGCTGGTCTTTTAGCTAGA	0.328000													23	65					0	0	0.069288	0	0
TRPM4	54795	broad.mit.edu	37	19	49674993	49674993	+	Silent	SNP	T	T	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr19:49674993T>C	ENST00000252826.5	+	8	1143	c.1017T>C	c.(1015-1017)ttT>ttC	p.F339F	TRPM4_ENST00000355712.5_Silent_p.F56F|TRPM4_ENST00000427978.2_Silent_p.F339F|TRPM4_ENST00000601347.1_3'UTR	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	339					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		GGCGTTTCTTTCCCAAAGGGG	0.637000													3	74					0	0	0.115264	0	0
ZNF727	442319	broad.mit.edu	37	7	63538726	63538726	+	Missense_Mutation	SNP	T	T	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr7:63538726T>A	ENST00000550760.3	+	4	1478	c.1299T>A	c.(1297-1299)ttT>ttA	p.F433L		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	433					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						GCAAAACCTTTAAGTGGTTCC	0.408000													3	10					0	0	0.150653	0	0
TPM3	7170	broad.mit.edu	37	1	154148674	154148674	+	Silent	SNP	T	T	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:154148674T>C	ENST00000368533.3	-	2	235	c.183A>G	c.(181-183)gaA>gaG	p.E61E	TPM3_ENST00000368530.2_Silent_p.E98E|TPM3_ENST00000368531.2_Silent_p.E61E|TPM3_ENST00000341485.5_Silent_p.E61E|TPM3_ENST00000330188.9_Silent_p.E61E|TPM3_ENST00000328159.4_Silent_p.E61E|TPM3_ENST00000341372.3_Intron|TPM3_ENST00000323144.7_Silent_p.E61E|TPM3_ENST00000302206.5_5'UTR|TPM3_ENST00000271850.7_Silent_p.E98E|TPM3_ENST00000469717.1_Intron	NM_001043352.1|NM_001278188.1|NM_153649.3	NP_001036817.1|NP_001265117.1|NP_705935.1	P06753	TPM3_HUMAN	tropomyosin 3	97					cellular component movement|muscle filament sliding|regulation of muscle contraction	cytosol|muscle thin filament tropomyosin|stress fiber	actin binding		TPM3/NTRK1_ENST00000392302(70)|TPM3/ALK(33)	breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)					GGTCCAGCTCTTCTTCAACCA	0.547000			T	"""NTRK1, ALK, ROS1"""	"""papillary thyroid, ALCL, NSCLC"""								76	253					0	0	0.139131	0	0
PROM2	150696	broad.mit.edu	37	2	95947024	95947024	+	Missense_Mutation	SNP	C	C	T	rs143192230		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr2:95947024C>T	ENST00000317620.9	+	12	1595	c.1462C>T	c.(1462-1464)Ctc>Ttc	p.L488F	PROM2_ENST00000542147.1_Missense_Mutation_p.L488F|PROM2_ENST00000403131.2_Missense_Mutation_p.L488F|PROM2_ENST00000317668.4_Missense_Mutation_p.L488F	NM_001165978.1	NP_001159450.1	Q8N271	PROM2_HUMAN	prominin 2	488						apical plasma membrane|basolateral plasma membrane|cilium membrane|integral to membrane|microvillus membrane				breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	32						TGCTGCACCCCTCATCCTCCT	0.632000													5	124					0	0	0.021553	0	0
DISP2	85455	broad.mit.edu	37	15	40660420	40660420	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr15:40660420C>G	ENST00000267889.3	+	8	2194	c.2107C>G	c.(2107-2109)Cgc>Ggc	p.R703G		NM_033510.1	NP_277045.1	A7MBM2	DISP2_HUMAN	dispatched homolog 2 (Drosophila)	703					smoothened signaling pathway	integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)	30		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;3.39e-06)|Colorectal(105;0.0114)|READ - Rectum adenocarcinoma(2;0.0649)|BRCA - Breast invasive adenocarcinoma(123;0.0798)|Lung(196;0.15)|LUAD - Lung adenocarcinoma(183;0.247)		CATCAAGTTCCGCTACATCTG	0.746000													6	22					0	0	0.047766	0	0
WDFY3	23001	broad.mit.edu	37	4	85750167	85750167	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr4:85750167G>C	ENST00000322366.6	-	9	1353	c.946C>G	c.(946-948)Ctc>Gtc	p.L316V	WDFY3_ENST00000295888.4_Missense_Mutation_p.L316V			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	316						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CTAAGCAAGAGATCACAAAGA	0.348000													11	99					0	0	0.069234	0	0
CLPTM1L	81037	broad.mit.edu	37	5	1323907	1323907	+	Silent	SNP	A	A	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr5:1323907A>G	ENST00000320895.5	-	12	1532	c.1275T>C	c.(1273-1275)taT>taC	p.Y425Y	CLPTM1L_ENST00000506641.1_5'UTR|CLPTM1L_ENST00000320927.6_Silent_p.Y389Y|CLPTM1L_ENST00000507807.1_Silent_p.Y256Y	NM_030782.3	NP_110409.2	Q96KA5	CLP1L_HUMAN	CLPTM1-like	425					apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24	Lung NSC(6;5.78e-14)|all_lung(6;4.47e-13)|all_epithelial(6;4.47e-09)		Epithelial(17;0.00931)|OV - Ovarian serous cystadenocarcinoma(19;0.0116)|all cancers(22;0.0181)	KIRC - Kidney renal clear cell carcinoma(5;0.177)|Kidney(13;0.208)		CCTACCTCTTATATTTGATAT	0.537000													3	33					0	0	0.115264	0	0
UNC13A	23025	broad.mit.edu	37	19	17743623	17743623	+	Silent	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr19:17743623G>A	ENST00000428389.2	-	29	3659	c.3660C>T	c.(3658-3660)ccC>ccT	p.P1220P	UNC13A_ENST00000252773.7_Silent_p.P1132P|UNC13A_ENST00000551649.1_Silent_p.P1132P|UNC13A_ENST00000550896.1_Silent_p.P1130P|UNC13A_ENST00000552293.1_Silent_p.P1132P|UNC13A_ENST00000519716.2_Silent_p.P1132P			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1132	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CCTTGAAGGCGGGAAGTTCCG	0.552000													12	55					0	0	0.105934	0	0
FAM168B	130074	broad.mit.edu	37	2	131829435	131829435	+	Silent	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr2:131829435G>A	ENST00000409185.1	-	3	254	c.147C>T	c.(145-147)ttC>ttT	p.F49F	FAM168B_ENST00000389915.3_Silent_p.F49F	NM_001009993.2	NP_001009993.2	A1KXE4	F168B_HUMAN	family with sequence similarity 168, member B	49										endometrium(3)|lung(2)	5						TACCTGTTTGGAAGGTAGGAT	0.463000													5	224					0	0	0.184627	0	0
SETD4	54093	broad.mit.edu	37	21	37418122	37418122	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr21:37418122G>A	ENST00000399215.1	-	5	1856	c.484C>T	c.(484-486)Cag>Tag	p.Q162*	SETD4_ENST00000399208.2_Nonsense_Mutation_p.Q162*|SETD4_ENST00000332131.4_Nonsense_Mutation_p.Q162*|SETD4_ENST00000399207.1_Nonsense_Mutation_p.Q162*|SETD4_ENST00000399201.1_Nonsense_Mutation_p.Q138*|SETD4_ENST00000399212.1_Nonsense_Mutation_p.Q138*|SETD4_ENST00000399205.1_Nonsense_Mutation_p.Q138*|SETD4_ENST00000481477.1_5'UTR			Q9NVD3	SETD4_HUMAN	SET domain containing 4	162	SET.									autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						TGGGCTCTCTGCTCTTCAGCC	0.493000													53	257					0	0	0.139131	0	0
HMOX1	3162	broad.mit.edu	37	22	35789561	35789561	+	Silent	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr22:35789561G>A	ENST00000216117.8	+	5	1176	c.837G>A	c.(835-837)gcG>gcA	p.A279A		NM_002133.2	NP_002124.1	P09601	HMOX1_HUMAN	heme oxygenase (decycling) 1	279					angiogenesis|anti-apoptosis|cell death|cellular iron ion homeostasis|endothelial cell proliferation|erythrocyte homeostasis|heme catabolic process|heme oxidation|intracellular protein kinase cascade|low-density lipoprotein particle clearance|negative regulation of leukocyte migration|negative regulation of smooth muscle cell proliferation|positive regulation of chemokine biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of smooth muscle cell proliferation|protein homooligomerization|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hydrogen peroxide|response to nicotine|smooth muscle hyperplasia|transmembrane transport|wound healing involved in inflammatory response	endoplasmic reticulum membrane|extracellular space|microsome	enzyme binding|heme binding|heme oxygenase (decyclizing) activity|protein homodimerization activity|signal transducer activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16					NADH(DB00157)	TTCTGGTGGCGACAGTTGCTG	0.577000													6	161					0	0	0.029380	0	0
GAD2	2572	broad.mit.edu	37	10	26581848	26581848	+	Silent	SNP	C	C	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr10:26581848C>A	ENST00000376261.3	+	15	2015	c.1512C>A	c.(1510-1512)gtC>gtA	p.V504V	GAD2_ENST00000259271.3_Silent_p.V504V	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	504					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	ACACAAATGTCTGCTTCTGGT	0.443000													47	372					2.17126e-26	2.48144e-26	0.139131	1	0
BMS1P20	96610	broad.mit.edu	37	22	22663087	22663087	+	RNA	SNP	A	A	G	rs1054158		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr22:22663087A>G	ENST00000426066.1	+	0	526					NR_027293.1																						GCTGCCACATAAGTTGTCCTT	0.303000													9	53					0	0	0.047766	0	0
SNRPB	6628	broad.mit.edu	37	20	2442419	2442419	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr20:2442419G>A	ENST00000438552.2	-	7	868	c.706C>T	c.(706-708)Cgc>Tgc	p.R236C	SNRPB_ENST00000381342.2_3'UTR	NM_198216.1	NP_937859.1	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	236	Repeat-rich region.				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						CTTGGTGGGCGCATTCCCGGG	0.547000													7	312					0	0	0.038147	0	0
NAE1	8883	broad.mit.edu	37	16	66847735	66847735	+	Silent	SNP	A	A	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr16:66847735A>T	ENST00000379463.2	-	13	1029	c.837T>A	c.(835-837)atT>atA	p.I279I	NAE1_ENST00000359087.4_Silent_p.I288I|NAE1_ENST00000290810.3_Silent_p.I285I|NAE1_ENST00000394074.2_Silent_p.I196I	NM_001018159.1	NP_001018169.1	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1	285					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	ATATATCTTCAATACTGCTTG	0.318000													17	170					0	0	0.175082	0	0
COQ9	57017	broad.mit.edu	37	16	57493630	57493630	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr16:57493630C>T	ENST00000262507.6	+	7	934	c.865C>T	c.(865-867)Cag>Tag	p.Q289*	COQ9_ENST00000567933.1_Nonsense_Mutation_p.Q178*|COQ9_ENST00000567072.1_Nonsense_Mutation_p.Q254*	NM_020312.3	NP_064708.1	O75208	COQ9_HUMAN	coenzyme Q9	289					ubiquinone biosynthetic process	mitochondrion				breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(1)	16						CACTGCCAAGCAGGTAGGTGG	0.537000													15	69					0	0	0.119110	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128742	45128742	+	RNA	SNP	T	T	G	rs34655963	by1000genomes	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr17:45128742T>G	ENST00000575173.1	-	0	418																											TAATGATTTTTATTATACTTT	0.328000													4	105					0	0	0.150653	0	0
MBNL2	10150	broad.mit.edu	37	13	97999179	97999179	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr13:97999179A>G	ENST00000345429.6	+	5	1443	c.662A>G	c.(661-663)tAc>tGc	p.Y221C	MBNL2_ENST00000445661.2_Intron|MBNL2_ENST00000397601.1_Missense_Mutation_p.Y221C|MBNL2_ENST00000343600.4_Missense_Mutation_p.Y221C|MBNL2_ENST00000376673.3_Missense_Mutation_p.Y221C	NM_144778.3	NP_659002.1	Q5VZF2	MBNL2_HUMAN	muscleblind-like splicing regulator 2	221					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding			endometrium(4)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			TGTATGGATTACATAAAGGGG	0.527000													66	203					0	0	0.139131	0	0
LRRC37BP1	147172	broad.mit.edu	37	17	28958975	28958975	+	RNA	SNP	T	T	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr17:28958975T>G	ENST00000578265.1	+	0	287				LRRC37BP1_ENST00000412831.1_RNA																							ACATCTTGCCTTATCTCTCAC	0.438000													13	191					0	0	0.105934	0	0
PCDHGC4	56098	broad.mit.edu	37	5	140864939	140864939	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr5:140864939G>A	ENST00000306593.1	+	1	199	c.199G>A	c.(199-201)Gct>Act	p.A67T	PCDHGA7_ENST00000518325.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA9_ENST00000573521.1_Intron	NM_018928.2|NM_032406.1	NP_061751.1|NP_115782.1														NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(13)|ovary(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	42			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCAGGTCGCTGGAGAGGT	0.572000													22	153					0	0	0.083992	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													9	54					0	0	0.047766	0	0
SH2D7	646892	broad.mit.edu	37	15	78393869	78393869	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr15:78393869C>A	ENST00000328828.5	+	5	1274	c.1274C>A	c.(1273-1275)aCc>aAc	p.T425N	SH2D7_ENST00000409568.2_Missense_Mutation_p.T289N	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	425										endometrium(2)|kidney(2)|lung(3)	7						ATCCCAGCAACCAAGAGCAAG	0.582000													4	20					0.150653	0.161896	0.150653	1	0
FRAS1	80144	broad.mit.edu	37	4	79400644	79400644	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr4:79400644G>A	ENST00000264895.6	+	56	8655	c.8215G>A	c.(8215-8217)Gcg>Acg	p.A2739T		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	2734	Calx-beta 2.				cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						GATGTCTGCCGCGAGTCGTGT	0.463000													30	103					0	0	0.163468	0	0
MFAP2	4237	broad.mit.edu	37	1	17302162	17302162	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:17302162C>T	ENST00000375535.3	-	7	639	c.350G>A	c.(349-351)tGt>tAt	p.C117Y	MFAP2_ENST00000490075.1_5'UTR|MFAP2_ENST00000438542.1_Missense_Mutation_p.C116Y|MFAP2_ENST00000375534.3_Missense_Mutation_p.C116Y			P55001	MFAP2_HUMAN	microfibrillar-associated protein 2	117						microfibril				kidney(1)|lung(1)	2		Colorectal(325;3.46e-05)|Breast(348;0.000118)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000538)|Ovarian(437;0.00669)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|COAD - Colon adenocarcinoma(227;1.07e-05)|BRCA - Breast invasive adenocarcinoma(304;3.04e-05)|Kidney(64;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00544)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.181)		CTCGTTGAGACACTGTTTGCA	0.612000													4	46					0	0	0.150653	0	0
TMEM71	137835	broad.mit.edu	37	8	133723166	133723166	+	Missense_Mutation	SNP	A	A	G	rs1895807	by1000genomes	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr8:133723166A>G	ENST00000523829.1	-	9	998	c.877T>C	c.(877-879)Tgg>Cgg	p.W293R	TMEM71_ENST00000377901.4_3'UTR|TMEM71_ENST00000356838.3_3'UTR			Q6P5X7	TMM71_HUMAN	transmembrane protein 71	0						integral to membrane				endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GACAATTTCCAGATATTCAGA	0.348000													5	199					0	0	0.184627	0	0
ALPI	248	broad.mit.edu	37	2	233321775	233321775	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr2:233321775A>G	ENST00000295463.3	+	4	544	c.467A>G	c.(466-468)aAg>aGg	p.K156R		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	156					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		AACCGGGCCAAGCAAGCAGGT	0.602000													4	8					0	0	0.150653	0	0
KIF3B	9371	broad.mit.edu	37	20	30898037	30898037	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr20:30898037C>T	ENST00000375712.3	+	2	624	c.457C>T	c.(457-459)Cga>Tga	p.R153*		NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	153	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGAGGAGATCCGAGATTTGCT	0.463000													24	78					0	0	0.076483	0	0
CYB5R1	51706	broad.mit.edu	37	1	202935709	202935709	+	Missense_Mutation	SNP	T	T	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:202935709T>C	ENST00000367249.4	-	3	259	c.185A>G	c.(184-186)aAg>aGg	p.K62R		NM_016243.2	NP_057327.2	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	62	FAD-binding FR-type.				sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			breast(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(75;0.141)			GCGGAACCTCTTGGTGTTGTG	0.612000													7	138					0	0	0.038147	0	0
OR5D13	390142	broad.mit.edu	37	11	55541050	55541050	+	Missense_Mutation	SNP	G	G	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr11:55541050G>C	ENST00000361760.1	+	1	137	c.137G>C	c.(136-138)gGc>gCc	p.G46A		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				GGGAACTTGGGCATGATAATA	0.388000													31	232					0	0	0.134883	0	0
AKAP6	9472	broad.mit.edu	37	14	32902910	32902910	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr14:32902910C>G	ENST00000280979.4	+	2	381	c.211C>G	c.(211-213)Cct>Gct	p.P71A	AKAP6_ENST00000554449.1_3'UTR|AKAP6_ENST00000557354.1_Missense_Mutation_p.P71A|AKAP6_ENST00000557272.1_Missense_Mutation_p.P71A	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	71					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		CCTCCACTTACCTGAAATTGA	0.522000													27	214					0	0	0.116897	0	0
MYBPHL	343263	broad.mit.edu	37	1	109839773	109839773	+	Missense_Mutation	SNP	C	C	T	rs140919452		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:109839773C>T	ENST00000357155.1	-	4	518	c.469G>A	c.(469-471)Gtt>Att	p.V157I	MYBPHL_ENST00000477962.1_Intron	NM_001010985.2|NM_001265613.1	NP_001010985.2|NP_001252542.1	A2RUH7	MBPHL_HUMAN	myosin binding protein H-like	157	Fibronectin type-III.									central_nervous_system(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(2)	14		all_lung(203;0.00519)|all_epithelial(167;0.00575)|Lung NSC(277;0.00822)		Colorectal(144;0.0306)|Lung(183;0.0681)|COAD - Colon adenocarcinoma(174;0.117)|Epithelial(280;0.197)|all cancers(265;0.225)		AAGCCCCAAACGTCCACCAGC	0.552000													42	218					0	0	0.086207	0	0
FANCB	2187	broad.mit.edu	37	X	14861792	14861792	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chrX:14861792G>A	ENST00000398334.1	-	10	2744	c.2477C>T	c.(2476-2478)aCg>aTg	p.T826M	FANCB_ENST00000324138.3_Missense_Mutation_p.T826M	NM_001018113.1	NP_001018123.1	Q8NB91	FANCB_HUMAN	Fanconi anemia, complementation group B	826					DNA repair	nucleoplasm				NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24	Hepatocellular(33;0.183)					TTTTAGGTTCGTTTGCAACAT	0.398000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				7	301					0	0	0.029380	0	0
FAAH	2166	broad.mit.edu	37	1	46871356	46871356	+	Silent	SNP	C	C	T			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:46871356C>T	ENST00000243167.8	+	5	759	c.675C>T	c.(673-675)atC>atT	p.I225I	FAAH_ENST00000493735.1_3'UTR	NM_001441.2	NP_001432.2	O00519	FAAH1_HUMAN	fatty acid amide hydrolase	225					fatty acid catabolic process	cytoplasm|cytoskeleton|endomembrane system|integral to membrane|organelle membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|fatty acid amide hydrolase activity			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	22	Acute lymphoblastic leukemia(166;0.155)				Propofol(DB00818)|Thiopental(DB00599)	GGGCCCTCATCGGGTCTGGAG	0.637000													21	98					0	0	0.204396	0	0
NFXL1	152518	broad.mit.edu	37	4	47853119	47853119	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr4:47853119C>G	ENST00000507489.1	-	22	2731	c.2555G>C	c.(2554-2556)aGa>aCa	p.R852T	NFXL1_ENST00000381538.3_Missense_Mutation_p.R852T	NM_001278624.1	NP_001265553.1	Q6ZNB6	NFXL1_HUMAN	nuclear transcription factor, X-box binding-like 1	852						integral to membrane|nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(4)	27						TACCTGTTGTCTTCGTTTTTC	0.343000													13	70					0	0	0.132662	0	0
ACSS1	84532	broad.mit.edu	37	20	25038481	25038481	+	Silent	SNP	G	G	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr20:25038481G>C	ENST00000323482.4	-	1	337	c.258C>G	c.(256-258)ccC>ccG	p.P86P	ACSS1_ENST00000432802.2_Silent_p.P86P|ACSS1_ENST00000376726.3_Silent_p.P86P	NM_001252675.1|NM_032501.3	NP_001239604.1|NP_115890.2	Q9NUB1	ACS2L_HUMAN	acyl-CoA synthetase short-chain family member 1	86					acetyl-CoA biosynthetic process|ethanol oxidation|xenobiotic metabolic process	mitochondrial matrix	acetate-CoA ligase activity|AMP binding|ATP binding|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CGGTGTGGTAGGGGGTGTCCC	0.662000													10	47					0	0	0.093190	0	0
FAM58A	92002	broad.mit.edu	37	X	152860004	152860004	+	Splice_Site	SNP	C	C	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chrX:152860004C>A	ENST00000406277.2	-	5	526		c.e5+1		FAM58A_ENST00000370175.4_Splice_Site	NM_001130997.1|NM_152274.3	NP_001124469.1|NP_689487.2	Q8N1B3	FA58A_HUMAN	family with sequence similarity 58, member A						regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCAGTATGTACCTTGTGTGGA	0.542000													36	96					6.05902e-23	6.8164e-23	0.193644	1	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													5	59					0	0	0.184627	0	0
MYO1A	4640	broad.mit.edu	37	12	57424944	57424944	+	Silent	SNP	T	T	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr12:57424944T>C	ENST00000442789.2	-	24	2651	c.2364A>G	c.(2362-2364)ctA>ctG	p.L788L	MYO1A_ENST00000300119.3_Silent_p.L788L|MYO1A_ENST00000544473.1_Silent_p.L626L	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	788					sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						TCAGCCCCAGTAGGAATTTCT	0.522000													28	164					0	0	0.144211	0	0
SPEN	23013	broad.mit.edu	37	1	16262679	16262680	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:16262679_16262680insC	ENST00000375759.3	+	11	10148_10149	c.9944_9945insC	c.(9943-9945)cccfs	p.P3315fs		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3315	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CGCACCTACCACCCCCCGGCCC	0.629													7	143	---	---	---	---					
CELSR2	1952	broad.mit.edu	37	1	109807570	109807571	+	Frame_Shift_Ins	INS	-	-	C	rs115193384	byFrequency	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:109807570_109807571insC	ENST00000271332.3	+	12	5606_5607	c.5545_5546insC	c.(5545-5547)cccfs	p.P1849fs		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	1849	EGF-like 6; calcium-binding.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		CAAGCCCAGTGCCCCCCATGGC	0.564													7	268	---	---	---	---					
WDR77	79084	broad.mit.edu	37	1	111991766	111991767	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:111991766_111991767insG	ENST00000235090.5	-	1	231_232	c.25_26insC	c.(25-27)agtfs	p.S9fs	WDR77_ENST00000411751.2_Frame_Shift_Ins_p.S9fs|ATP5F1_ENST00000369722.3_5'UTR	NM_024102.2	NP_077007.1	Q9BQA1	MEP50_HUMAN	WD repeat domain 77	9					ncRNA metabolic process|spliceosomal snRNP assembly	cytosol|nucleus	ligand-dependent nuclear receptor transcription coactivator activity|protein binding	p.L9fs*1(1)		NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		all_cancers(81;0.000902)|all_epithelial(167;0.00056)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		CGGGGGCACTAGGGGGGGTGGG	0.668													8	76	---	---	---	---					
PIAS3	10401	broad.mit.edu	37	1	145578277	145578278	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:145578277_145578278insC	ENST00000393045.2	+	2	330_331	c.240_241insC	c.(238-243)ttccccfs	p.FP80fs	PIAS3_ENST00000369299.3_Frame_Shift_Ins_p.FP71fs|PIAS3_ENST00000369298.1_Frame_Shift_Ins_p.FP80fs	NM_006099.3	NP_006090.2	Q9Y6X2	PIAS3_HUMAN	protein inhibitor of activated STAT, 3	80					positive regulation of protein sumoylation|protein sumoylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck	enzyme binding|nucleic acid binding|protein C-terminus binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)	28	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TTCTCTCTTTGCCCCCTGGCAC	0.624													7	1532	---	---	---	---					
SLC50A1	55974	broad.mit.edu	37	1	155110672	155110673	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:155110672_155110673insA	ENST00000368404.4	+	6	643_644	c.581_582insA	c.(580-582)gatfs	p.D194fs	SLC50A1_ENST00000303343.8_Frame_Shift_Ins_p.D140fs|SLC50A1_ENST00000484157.1_Frame_Shift_Ins_p.D129fs|SLC50A1_ENST00000368401.5_Frame_Shift_Ins_p.D139fs|SLC50A1_ENST00000368405.3_3'UTR	NM_018845.3	NP_061333.2	Q9BRV3	SWET1_HUMAN	solute carrier family 50 (sugar efflux transporter), member 1	194	Mediates interaction with TRPV2 (By similarity).|MtN3/slv 2.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity			endometrium(1)|lung(1)|ovary(1)|skin(1)	4						AACTTTCCAGGAATCGTCACCA	0.520													30	104	---	---	---	---					
SWT1	54823	broad.mit.edu	37	1	185183720	185183721	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:185183720_185183721insA	ENST00000367500.4	+	14	2219_2220	c.2054_2055insA	c.(2053-2055)taafs	p.*685fs	SWT1_ENST00000367501.3_Frame_Shift_Ins_p.*685fs	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	685										breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						AGTACAAGGTCAAATTATGATG	0.381													35	131	---	---	---	---					
FMN2	56776	broad.mit.edu	37	1	240255569	240255571	+	In_Frame_Del	DEL	GGC	GGC	-	rs71929261		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr1:240255569_240255571delGGC	ENST00000319653.9	+	1	390_392	c.160_162delGGC	c.(160-162)del	p.G59del		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	59					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.G197delG(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GGGGGGAgggggcggcggcggcg	0.665													4	7	---	---	---	---					
LOC101928553	101928553	broad.mit.edu	37	2	149629672	149629673	+	RNA	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr2:149629672_149629673insC	ENST00000601658.1	-	0	676																											CTCTGGCCCTGCCCCCCCCCAA	0.441													3	6	---	---	---	---					
HOXD8	3234	broad.mit.edu	37	2	176995416	176995417	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr2:176995416_176995417insC	ENST00000313173.4	+	1	949_950	c.322_323insC	c.(322-324)cccfs	p.P108fs	HOXD8_ENST00000544999.1_Frame_Shift_Ins_p.P108fs|HOXD8_ENST00000429017.1_Intron|HOXD8_ENST00000450510.2_Frame_Shift_Ins_p.P108fs|HOXD-AS2_ENST00000440016.2_RNA|HOXD8_ENST00000548663.1_Intron	NM_001199746.1|NM_019558.3	NP_001186675.1|NP_062458.1	P13378	HXD8_HUMAN	homeobox D8	108					anterior/posterior axis specification, embryo	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(5)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.195)	Colorectal(32;0.0224)|READ - Rectum adenocarcinoma(9;0.0556)		CTACCAGGCCGccccccctcct	0.743													11	205	---	---	---	---					
STAT1	6772	broad.mit.edu	37	2	191862616	191862617	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr2:191862616_191862617insC	ENST00000361099.3	-	9	1137_1138	c.750_751insG	c.(748-753)ggcgccfs	p.A251fs	STAT1_ENST00000409465.1_Frame_Shift_Ins_p.A251fs|STAT1_ENST00000392322.3_Frame_Shift_Ins_p.A251fs|STAT1_ENST00000392323.2_Frame_Shift_Ins_p.A253fs|STAT1_ENST00000540176.1_3'UTR	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	251					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	GCATTGGGCGGCCCCCCAATAC	0.475													8	293	---	---	---	---					
CTLA4	1493	broad.mit.edu	37	2	204736166	204736166	+	Frame_Shift_Del	DEL	T	T	-			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr2:204736166delT	ENST00000302823.3	+	3	680	c.523delT	c.(523-525)ttfs	p.F176fs	CTLA4_ENST00000472206.1_Intron|CTLA4_ENST00000295854.6_Intron|CTLA4_ENST00000427473.2_Intron|CTLA4_ENST00000487393.1_Intron	NM_005214.4	NP_005205.2	P16410	CTLA4_HUMAN	cytotoxic T-lymphocyte-associated protein 4	176					B cell receptor signaling pathway|immune response|negative regulation of B cell proliferation|negative regulation of regulatory T cell differentiation|positive regulation of apoptosis|response to DNA damage stimulus|T cell costimulation	clathrin-coated endocytic vesicle|external side of plasma membrane|Golgi apparatus|integral to plasma membrane|perinuclear region of cytoplasm				large_intestine(4)|lung(4)|skin(1)	9					Abatacept(DB01281)	TTCGGGGTTGTTTTTTTATAG	0.478													8	1085	---	---	---	---					
PTPRN	5798	broad.mit.edu	37	2	220168477	220168478	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr2:220168477_220168478insG	ENST00000295718.2	-	4	596_597	c.356_357insC	c.(355-357)cgafs	p.R119fs	PTPRN_ENST00000409251.3_Frame_Shift_Ins_p.R119fs|PTPRN_ENST00000423636.2_Frame_Shift_Ins_p.R29fs|AC114803.3_ENST00000417355.1_RNA	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	119					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GACGGGGCTCTGGGGGGCGAAG	0.550													8	285	---	---	---	---					
SUCLG2-AS1	101927111	broad.mit.edu	37	3	67941565	67941566	+	RNA	INS	-	-	ACAC	rs35166614		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr3:67941565_67941566insACAC	ENST00000482677.1	+	0	1653																											caataATAGATacacacacaca	0.356													6	2	---	---	---	---					
PHC3	80012	broad.mit.edu	37	3	169890470	169890471	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr3:169890470_169890471insG	ENST00000494943.1	-	3	242_243	c.174_175insC	c.(172-177)ccgctcfs	p.L59fs	PHC3_ENST00000495893.1_Frame_Shift_Ins_p.L71fs|PHC3_ENST00000474275.1_Frame_Shift_Ins_p.L55fs|PHC3_ENST00000481639.1_Frame_Shift_Ins_p.L67fs|PHC3_ENST00000497658.1_Frame_Shift_Ins_p.L71fs|PHC3_ENST00000467570.1_Frame_Shift_Ins_p.L71fs			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	59					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GCAGCTGAGCTGGGGGGCCGAT	0.441													10	920	---	---	---	---					
YTHDC1	91746	broad.mit.edu	37	4	69188585	69188586	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr4:69188585_69188586insG	ENST00000344157.4	-	11	1817_1818	c.1482_1483insC	c.(1480-1485)ccatgafs	p.*495fs	YTHDC1_ENST00000579690.1_Frame_Shift_Ins_p.*495fs|YTHDC1_ENST00000355665.3_Frame_Shift_Ins_p.*477fs	NM_001031732.2	NP_001026902.1	Q96MU7	YTDC1_HUMAN	YTH domain containing 1	495										NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	30						ATACTTTCATCGGGGGGAAACA	0.426													7	197	---	---	---	---					
CDK7	1022	broad.mit.edu	37	5	68572376	68572378	+	In_Frame_Del	DEL	AAA	AAA	-			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr5:68572376_68572378delAAA	ENST00000502604.1	+	10	1082_1084	c.592_594delAAA	c.(592-594)del	p.K198del	CDK7_ENST00000514676.1_In_Frame_Del_p.K254del|CDK7_ENST00000256443.3_In_Frame_Del_p.K291del			P50613	CDK7_HUMAN	cyclin-dependent kinase 7	291	Protein kinase.				androgen receptor signaling pathway|cell division|cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex|mitochondrion	androgen receptor binding|ATP binding|cyclin-dependent protein kinase activity|DNA-dependent ATPase activity|protein C-terminus binding|RNA polymerase II carboxy-terminal domain kinase activity|transcription coactivator activity			endometrium(1)|lung(2)	3		Lung NSC(167;7.26e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.98e-56)|Epithelial(20;3.54e-52)|all cancers(19;9.11e-48)|Lung(70;0.0185)		AAAGGCACTGAAAATGAAGTATT	0.389								Nucleotide excision repair (NER)					35	126	---	---	---	---					
DDX39B	7919	broad.mit.edu	37	6	31500690	31500691	+	Splice_Site	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr6:31500690_31500691insG	ENST00000417556.2	-	8	1411		c.e8-2		DDX39B_ENST00000458640.1_Splice_Site|DDX39B_ENST00000376177.2_Splice_Site|DDX39B_ENST00000396172.1_Splice_Site|DDX39B_ENST00000415382.2_Splice_Site|ATP6V1G2-DDX39B_ENST00000376185.1_Splice_Site			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B						intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						CTCCATTGGCTgggggggagga	0.579													9	153	---	---	---	---					
SLC39A7	7922	broad.mit.edu	37	6	33171547	33171548	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr6:33171547_33171548insG	ENST00000374677.3	+	7	1740_1741	c.1367_1368insG	c.(1366-1368)cggfs	p.R456fs	SLC39A7_ENST00000463972.1_3'UTR|SLC39A7_ENST00000374675.3_Frame_Shift_Ins_p.R456fs	NM_006979.2	NP_008910.2	Q92504	S39A7_HUMAN	solute carrier family 39 (zinc transporter), member 7	456				CALLTEGGAVGSEIAGGAGPGWVLPFTAGGFIYVATVSVLP ELLREASPLQSLLEVLGLLGGVIMMVLIAHLE -> VPFSL KEEQWTVKLQVVQVLAGSCHLLQVALST (in Ref. 1; BAA11528 and 2; AAD12305).		endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein binding|zinc ion transmembrane transporter activity			NS(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	18						CTGGGGCTGCTGGGGGGAGTTA	0.564													7	318	---	---	---	---					
COL19A1	1310	broad.mit.edu	37	6	70916893	70916894	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr6:70916893_70916894insC	ENST00000322773.4	+	51	3446_3447	c.3344_3345insC	c.(3343-3345)gccfs	p.A1115fs	COL19A1_ENST00000393344.1_Frame_Shift_Ins_p.A737fs	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	1115					cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GGCCCACAGGGCCCCCCAGGAC	0.525													8	609	---	---	---	---					
LAMA2	3908	broad.mit.edu	37	6	129714239	129714240	+	Frame_Shift_Ins	INS	-	-	G	rs138296015	by1000genomes	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr6:129714239_129714240insG	ENST00000421865.2	+	37	5333_5334	c.5284_5285insG	c.(5284-5286)gggfs	p.G1762fs		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1762	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TGGAGAGTCCCGGGGGGAAAAT	0.465													7	177	---	---	---	---					
ALDH8A1	64577	broad.mit.edu	37	6	135253995	135253996	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr6:135253995_135253996insC	ENST00000265605.2	-	5	835_836	c.767_768insG	c.(766-768)gaafs	p.E256fs	ALDH8A1_ENST00000367845.2_Frame_Shift_Ins_p.E256fs|ALDH8A1_ENST00000367847.2_Frame_Shift_Ins_p.E206fs	NM_022568.3	NP_072090.1	Q9H2A2	AL8A1_HUMAN	aldehyde dehydrogenase 8 family, member A1	256					retinal metabolic process	cytoplasm	retinal dehydrogenase activity	p.G256D(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	36	Colorectal(23;0.221)			OV - Ovarian serous cystadenocarcinoma(155;0.00401)|GBM - Glioblastoma multiforme(68;0.0058)		CAGGATTCTTGCCCCCCAGCTC	0.619													7	251	---	---	---	---					
TRGC1	6966	broad.mit.edu	37	7	38301855	38301856	+	RNA	DEL	GT	GT	-			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr7:38301855_38301856delGT	ENST00000443402.2	-	0	330					NM_001003799.1|NM_001003806.1	NP_001003799.1|NP_001003806.1																					TCAATTGTTCGTGTGTGTGTGT	0.356													9	419	---	---	---	---					
TNS3	64759	broad.mit.edu	37	7	47385877	47385878	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr7:47385877_47385878insC	ENST00000398879.1	-	18	2724_2725	c.2358_2359insG	c.(2356-2361)ggagctfs	p.A787fs	TNS3_ENST00000355730.3_Frame_Shift_Ins_p.A547fs|TNS3_ENST00000311160.9_Frame_Shift_Ins_p.A787fs			Q68CZ2	TENS3_HUMAN	tensin 3	787						focal adhesion	protein binding			NS(1)|autonomic_ganglia(1)|breast(17)|endometrium(5)|kidney(4)|large_intestine(7)|liver(1)|lung(16)|ovary(4)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	64						AAGGGCAGCTGCCCCCCAGCAT	0.604													10	403	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55249012	55249013	+	In_Frame_Ins	INS	-	-	GGGTTA	rs121913445		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr7:55249012_55249013insGGGTTA	ENST00000275493.2	+	20	2487_2488	c.2310_2311insGGGTTA	c.(2308-2313)gaaccc>gaGGGTTAaccc	p.770_771EP>EG*P	EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_In_Frame_Ins_p.717_718EP>EG*P|EGFR-AS1_ENST00000442411.1_RNA|EGFR_ENST00000455089.1_In_Frame_Ins_p.725_726EP>EG*P	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	770	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.D770_N771insSVD(9)|p.D770_N771insG(6)|p.N771>TH(1)|p.N771>GY(1)|p.N771_P772insRH(1)|p.N771>SH(1)|p.V769_D770insASV(1)|p.D770_N771insN(1)|p.D770_N771insNPH(1)|p.D770_N771>AGG(1)|p.D770_N771insGF(1)|p.D770_N771insGD(1)|p.D770_N771insAPW(1)|p.N771>GF(1)|p.D770_N771insMATP(1)|p.D770_N771insGL(1)|p.D770fs*61(1)|p.D770_P772>ASVDNR(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CCAGCGTGGACAACCCCCACGT	0.649		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			64	182	---	---	---	---					
FBXO24	26261	broad.mit.edu	37	7	100187685	100187686	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr7:100187685_100187686insC	ENST00000241071.6	+	2	447_448	c.125_126insC	c.(124-126)tccfs	p.S42fs	FBXO24_ENST00000465843.1_Frame_Shift_Ins_p.S42fs|FBXO24_ENST00000360609.2_Frame_Shift_Ins_p.S42fs|FBXO24_ENST00000498195.1_3'UTR|FBXO24_ENST00000427939.2_Frame_Shift_Ins_p.S80fs|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000468962.1_Frame_Shift_Ins_p.S30fs	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	42	F-box.					ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					ATCCAGTTGTTCCCCCCAGAGC	0.569													9	451	---	---	---	---					
TRIM56	81844	broad.mit.edu	37	7	100732112	100732113	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr7:100732112_100732113insC	ENST00000306085.6	+	3	1816_1817	c.1519_1520insC	c.(1519-1521)cccfs	p.P507fs		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	507					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					AGACAAGCGGTCCCCCCGGATC	0.658													7	344	---	---	---	---					
TG	7038	broad.mit.edu	37	8	133906031	133906032	+	Frame_Shift_Ins	INS	-	-	G	rs114356482	byFrequency	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr8:133906031_133906032insG	ENST00000220616.4	+	11	2898_2899	c.2858_2859insG	c.(2857-2859)cggfs	p.R953fs	TG_ENST00000377869.1_Frame_Shift_Ins_p.R953fs	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	953	Thyroglobulin type-1 8.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CGGTTCCCTCTGGGGGAGAGTT	0.579													11	797	---	---	---	---					
MROH5	389690	broad.mit.edu	37	8	142445062	142445063	+	RNA	INS	-	-	G	rs79308669	by1000genomes	TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr8:142445062_142445063insG	ENST00000606664.1	+	0	418_419				MROH5_ENST00000430863.1_RNA																							TGGGACGGGCTGGGGGCCCTGG	0.644													5	11	---	---	---	---					
ABO	28	broad.mit.edu	37	9	136131057	136131057	+	RNA	DEL	G	G	-	rs8176750		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr9:136131057delG	ENST00000453660.2	-	0	1071							P16442	BGAT_HUMAN	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)						protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	fucosylgalactoside 3-alpha-galactosyltransferase activity|glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity|metal ion binding	p.P353fs?(1)		central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(2)|prostate(1)|stomach(2)	11				OV - Ovarian serous cystadenocarcinoma(145;5.82e-06)|Epithelial(140;3.45e-05)		AGCCGCTCACGGGTTCCGGAC	0.662													9	12	---	---	---	---					
AP2A2	161	broad.mit.edu	37	11	1009103	1009104	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr11:1009103_1009104insG	ENST00000448903.2	+	19	2565_2566	c.2424_2425insG	c.(2422-2427)taggggfs	p.*G808fs	AP2A2_ENST00000332231.5_Frame_Shift_Ins_p.*G809fs|AP2A2_ENST00000525891.1_3'UTR|AP2A2_ENST00000534328.1_Intron	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	808					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		CTGGCAGGTATGGGGGCACCTT	0.545													2	4	---	---	---	---					
TUBA3C	7278	broad.mit.edu	37	13	19751596	19751597	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr13:19751596_19751597insG	ENST00000400113.3	-	4	630_631	c.526_527insC	c.(526-528)ggtfs	p.G176fs		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	176					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		CGTGGAGACCTGGGGGGCTGGG	0.574													8	286	---	---	---	---					
RNF219-AS1	100874222	broad.mit.edu	37	13	79066554	79066554	+	RNA	DEL	T	T	-	rs140080527		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr13:79066554delT	ENST00000607862.1	+	0	315				RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000444769.3_RNA|RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000606803.1_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000605996.1_RNA|RNF219-AS1_ENST00000560209.2_RNA																							TGAAAAAAAATAATgaaagaa	0.403													2	4	---	---	---	---					
CDH24	64403	broad.mit.edu	37	14	23523784	23523785	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr14:23523784_23523785insC	ENST00000397359.3	-	5	973_974	c.714_715insG	c.(712-717)ggtgtcfs	p.V239fs	CDH24_ENST00000487137.2_Frame_Shift_Ins_p.V239fs|CDH24_ENST00000267383.5_Frame_Shift_Ins_p.V239fs|CDH24_ENST00000554034.1_Frame_Shift_Ins_p.V239fs	NM_022478.3	NP_071923.2	Q86UP0	CAD24_HUMAN	cadherin 24, type 2	239	Cadherin 2.				adherens junction organization|cell junction assembly|cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|delta-catenin binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(95;3.3e-05)			GBM - Glioblastoma multiforme(265;0.00654)		CTGCCTGACAGCCCCCCCATGT	0.609											OREG0022594	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	73	---	---	---	---					
IGHG2	3501	broad.mit.edu	37	14	106110246	106110247	+	RNA	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr14:106110246_106110247insG	ENST00000390545.2	-	0	370_371																											CCTTGGGTTTTGGGGGGAAGAG	0.619													12	475	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72993508	72993509	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr16:72993508_72993509insC	ENST00000268489.5	-	2	1208_1209	c.536_537insG	c.(535-537)gaafs	p.E179fs	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	179					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				CCCCTTGCTTGCCCCCCGCGCC	0.639													7	139	---	---	---	---					
RP11-192H23.4	0	broad.mit.edu	37	17	26940601	26940602	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr17:26940601_26940602insC	ENST00000534850.1	-	2	211_212	c.180_181insG	c.(178-183)ggaccafs	p.P61fs	RP11-192H23.4_ENST00000577790.1_Frame_Shift_Ins_p.P60fs|SGK494_ENST00000301037.5_Frame_Shift_Ins_p.P61fs|SPAG5-AS1_ENST00000554154.1_RNA|SGK494_ENST00000469832.3_5'UTR|SPAG5-AS1_ENST00000424210.1_RNA																endometrium(2)|kidney(2)	4						AGATAGTGGTGCCCCCGTAGTT	0.579											OREG0024279	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	585	---	---	---	---					
PHF12	57649	broad.mit.edu	37	17	27244345	27244346	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr17:27244345_27244346insG	ENST00000577226.1	-	7	1437_1438	c.1091_1092insC	c.(1090-1092)caafs	p.Q364fs	PHF12_ENST00000332830.4_Frame_Shift_Ins_p.Q364fs|PHF12_ENST00000582655.1_5'UTR|PHF12_ENST00000268756.3_Frame_Shift_Ins_p.Q364fs			Q96QT6	PHF12_HUMAN	PHD finger protein 12	364	Interaction with SIN3A.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			CACGCCGGTTAGGGGGGTGCTT	0.530													7	434	---	---	---	---					
OMG	4974	broad.mit.edu	37	17	29622166	29622167	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr17:29622166_29622167insG	ENST00000247271.4	-	2	1444_1445	c.1183_1184insC	c.(1183-1185)acafs	p.T395fs	NF1_ENST00000356175.3_Intron|NF1_ENST00000358273.4_Intron	NM_002544.4	NP_002535.3	P23515	OMGP_HUMAN	oligodendrocyte myelin glycoprotein	395					cell adhesion|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|plasma membrane		p.0?(8)|p.?(3)|p.Q395*(1)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(1)|ovary(1)|prostate(1)|stomach(1)	13		all_cancers(10;6.97e-11)|all_epithelial(10;0.0051)|all_hematologic(16;0.0149)|Breast(31;0.0155)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0257)|all_lung(9;0.0468)|Lung NSC(157;0.094)		UCEC - Uterine corpus endometrioid carcinoma (4;6.64e-05)|all cancers(4;1.81e-13)|Epithelial(4;4.04e-12)|OV - Ovarian serous cystadenocarcinoma(4;9.49e-12)|GBM - Glioblastoma multiforme(4;0.121)		TGTGCTTTGTTGAGGCATTTCA	0.416													22	1173	---	---	---	---					
AOC2	314	broad.mit.edu	37	17	40996940	40996941	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr17:40996940_40996941insC	ENST00000253799.3	+	1	324_325	c.297_298insC	c.(295-300)ctccccfs	p.LP99fs	AOC2_ENST00000452774.2_Frame_Shift_Ins_p.LP99fs	NM_009590.2	NP_033720.2	O75106	AOC2_HUMAN	amine oxidase, copper containing 2 (retina-specific)	99					catecholamine metabolic process|visual perception	cytoplasm|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|electron carrier activity|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(14)|ovary(4)|skin(2)	30		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)		AGCTGCAGCTGCCCCCCAAGGC	0.678													9	412	---	---	---	---					
NPIPB1P	729602	broad.mit.edu	37	18	11625378	11625379	+	RNA	INS	-	-	A	rs141097667		TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr18:11625378_11625379insA	ENST00000547442.1	-	0	621																											CTCTTCCCCCGAAAAATGACAA	0.401													3	5	---	---	---	---					
SLC17A7	57030	broad.mit.edu	37	19	49937127	49937128	+	Splice_Site	INS	-	-	G			TCGA-17-Z048-01A-01W-0746-08	TCGA-17-Z048-11A-01W-0746-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8495e150-796b-4e15-9fa6-1fba558d7b10	8f42138c-1c2f-470c-b8d4-fea0b78abcef	g.chr19:49937127_49937128insG	ENST00000221485.3	-	7	896		c.e7-2		SLC17A7_ENST00000600601.1_Splice_Site|SLC17A7_ENST00000543531.1_Splice_Site	NM_020309.3	NP_064705.1	Q9P2U7	VGLU1_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 7						glutamate secretion|neurotransmitter secretion	cell junction|clathrin sculpted glutamate transport vesicle membrane|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|sodium-dependent phosphate transmembrane transporter activity|sodium:inorganic phosphate symporter activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(7)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	26		all_lung(116;1.62e-07)|Lung NSC(112;8.47e-07)|all_neural(266;0.0381)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(486;0.0245)		CGAAGCTGCCTGGGGGGGTCAG	0.678													7	133	---	---	---	---					
