Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
UBBP4	23666	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R|UBBP4_ENST00000583708.1_3'UTR														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													4	87					0	0	0.150653	0	0
PGGT1B	5229	broad.mit.edu	37	5	114573612	114573612	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr5:114573612C>A	ENST00000419445.1	-	4	442	c.422G>T	c.(421-423)cGa>cTa	p.R141L	PGGT1B_ENST00000379615.3_Missense_Mutation_p.R141L	NM_005023.3	NP_005014.2	P53609	PGTB1_HUMAN	protein geranylgeranyltransferase type I, beta subunit	141					protein geranylgeranylation	CAAX-protein geranylgeranyltransferase complex	CAAX-protein geranylgeranyltransferase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(1)	6		all_cancers(142;0.000523)|all_epithelial(76;6.45e-06)|Prostate(80;0.00955)|Ovarian(225;0.0443)|all_lung(232;0.132)|Breast(839;0.195)		Epithelial(69;2.95e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.98e-08)|all cancers(49;3.1e-06)	Pravastatin(DB00175)	TTTATTTACTCGGCTTAAGTC	0.418000													7	354					0.00136819	0.0017706	0.411799	1	0
SON	6651	broad.mit.edu	37	21	34925822	34925822	+	Missense_Mutation	SNP	C	C	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr21:34925822C>A	ENST00000356577.4	+	3	4760	c.4285C>A	c.(4285-4287)Cct>Act	p.P1429T	SON_ENST00000290239.6_Missense_Mutation_p.P1429T|SON_ENST00000381679.4_Missense_Mutation_p.P1429T|SON_ENST00000381692.2_Intron|SON_ENST00000300278.4_Missense_Mutation_p.P1429T	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	1429					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						AGTCCTTCAACCTTCTATGAT	0.493000													3	94					0.150653	0.174441	0.150653	1	0
BMF	90427	broad.mit.edu	37	15	40396525	40396525	+	Silent	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr15:40396525C>T	ENST00000354670.4	-	4	543	c.309G>A	c.(307-309)cgG>cgA	p.R103R	BMF_ENST00000220446.4_Intron|BMF_ENST00000561282.1_Silent_p.R103R|BMF_ENST00000559701.1_Intron|BMF_ENST00000431415.3_Silent_p.R103R|BMF_ENST00000558774.1_Intron|BMF_ENST00000397573.1_Silent_p.R103R|BMF_ENST00000561360.1_Silent_p.R103R	NM_001003940.1	NP_001003940.1	Q96LC9	BMF_HUMAN	Bcl2 modifying factor	103					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria	cytosol|mitochondrial outer membrane|myosin complex|plasma membrane	protein binding			endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	6		all_cancers(109;4.18e-18)|all_epithelial(112;6.15e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.29e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0516)		GGAGAGGAAGCCGATAGCCAG	0.572000													3	25					0	0	0.115264	0	0
PLCD3	113026	broad.mit.edu	37	17	43194081	43194081	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr17:43194081C>T	ENST00000322765.5	-	8	1444	c.1331G>A	c.(1330-1332)cGc>cAc	p.R444H	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	444	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	GCAGAGGTGGCGGGCCATGGC	0.672000													3	18					0	0	0.115264	0	0
NINJ2	4815	broad.mit.edu	37	12	675233	675233	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr12:675233G>A	ENST00000305108.4	-	2	563	c.283C>T	c.(283-285)Cgg>Tgg	p.R95W	NINJ2_ENST00000542920.1_Missense_Mutation_p.R13W|NINJ2_ENST00000537416.1_Intron|NINJ2_ENST00000397265.3_Missense_Mutation_p.R42W|NINJ2_ENST00000433832.2_Missense_Mutation_p.R13W	NM_016533.4	NP_057617.2	Q9NZG7	NINJ2_HUMAN	ninjurin 2	49					nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				large_intestine(3)|lung(1)|ovary(2)	6	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			GCCTTCAGCCGCATGGCGTTG	0.612000													3	32					0	0	0.115264	0	0
SERINC5	256987	broad.mit.edu	37	5	79498750	79498750	+	Silent	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr5:79498750G>A	ENST00000507668.2	-	2	300	c.150C>T	c.(148-150)tgC>tgT	p.C50C	SERINC5_ENST00000512721.1_Silent_p.C50C|SERINC5_ENST00000513907.1_5'UTR|SERINC5_ENST00000512972.2_Silent_p.C50C|SERINC5_ENST00000509193.1_Silent_p.C50C	NM_001174071.1|NM_178276.5	NP_001167542.1|NP_840060.1	Q86VE9	SERC5_HUMAN	serine incorporator 5	50					phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|kidney(1)|lung(3)|ovary(1)	8		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		TCATGATGCAGCAGAGGACGA	0.532000													3	70					0	0	0.115264	0	0
DCLK1	9201	broad.mit.edu	37	13	36686230	36686230	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr13:36686230C>T	ENST00000255448.4	-	3	710	c.499G>A	c.(499-501)Gcc>Acc	p.A167T	DCLK1_ENST00000379892.4_Missense_Mutation_p.A167T|DCLK1_ENST00000360631.3_Missense_Mutation_p.A167T	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	167					cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TTGGCAGTGGCCAGTGAAGAC	0.537000													3	51					0	0	0.150653	0	0
OR5D13	390142	broad.mit.edu	37	11	55541604	55541604	+	Nonsense_Mutation	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr11:55541604C>T	ENST00000361760.1	+	1	691	c.691C>T	c.(691-693)Cga>Tga	p.R231*		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TATGAAGATGCGATCTGCAAG	0.428000													5	284					0	0	0.184627	0	0
MCHR1	2847	broad.mit.edu	37	22	41075734	41075734	+	Silent	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr22:41075734G>A	ENST00000249016.4	+	1	981	c.285G>A	c.(283-285)tcG>tcA	p.S95S	MCHR1_ENST00000498400.1_Intron|MCHR1_ENST00000381433.2_Silent_p.S95S	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	95					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						ACCTCACTTCGGCAGGTGAGT	0.597000													3	77					0	0	0.115264	0	0
HIVEP1	3096	broad.mit.edu	37	6	12122555	12122555	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr6:12122555C>T	ENST00000379388.2	+	4	2859	c.2527C>T	c.(2527-2529)Ccg>Tcg	p.P843S		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	843					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				TAATTCCATGCCGACCACAGG	0.408000													6	478					0	0	0.217242	0	0
DNMT1	1786	broad.mit.edu	37	19	10265690	10265690	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr19:10265690G>A	ENST00000340748.4	-	19	1722	c.1487C>T	c.(1486-1488)gCg>gTg	p.A496V	DNMT1_ENST00000359526.4_Missense_Mutation_p.A512V|DNMT1_ENST00000540357.1_Missense_Mutation_p.A496V			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	496	DNA replication foci-targeting sequence (By similarity).|Homodimerization.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	AAATATGGGCGCATACTCGGG	0.522000													3	30					0	0	0.115264	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													8	190					0	0	0.278610	0	0
PPOX	5498	broad.mit.edu	37	1	161140729	161140729	+	Nonsense_Mutation	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr1:161140729G>A	ENST00000367999.4	+	12	1547	c.1281G>A	c.(1279-1281)tgG>tgA	p.W427*	PPOX_ENST00000544598.1_Nonsense_Mutation_p.W135*|PPOX_ENST00000535223.1_Intron|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000352210.5_Nonsense_Mutation_p.W427*|PPOX_ENST00000495483.1_Intron	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	427					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity	p.W427*(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TAGGTCACTGGCAAAAACTAG	0.478000													5	235					0	0	0.217242	0	0
CR1	1378	broad.mit.edu	37	1	207762112	207762112	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr1:207762112A>G	ENST00000367049.4	+	35	5803	c.5803A>G	c.(5803-5805)Aat>Gat	p.N1935D	CR1_ENST00000367052.1_Missense_Mutation_p.N1485D|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367053.1_Missense_Mutation_p.N1485D|CR1_ENST00000400960.2_Missense_Mutation_p.N1485D|CR1_ENST00000367051.1_Missense_Mutation_p.N1485D|RP11-78B10.2_ENST00000597497.1_RNA	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1485	Sushi 30.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TTATTCTTGTAATGAAGGGTG	0.408000													6	92					0	0	0.217242	0	0
RYR3	6263	broad.mit.edu	37	15	34060876	34060876	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr15:34060876C>T	ENST00000389232.4	+	61	8793	c.8723C>T	c.(8722-8724)gCc>gTc	p.A2908V	RYR3_ENST00000415757.3_Missense_Mutation_p.A2908V	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2908					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TGCAAACTTGCCGCTCTCGTT	0.448000													5	306					0	0	0.248553	0	0
LINC00886	730091	broad.mit.edu	37	3	156527708	156527708	+	RNA	SNP	G	G	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr3:156527708G>T	ENST00000472943.1	-	0	148					NR_038387.1																						GCATCAAAACGCGTTTCCACC	0.448000													3	59					0.115264	0.137071	0.115264	1	0
RAG1	5896	broad.mit.edu	37	11	36595447	36595447	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr11:36595447G>A	ENST00000299440.5	+	2	705	c.593G>A	c.(592-594)aGg>aAg	p.R198K		NM_000448.2	NP_000439.1	P15918	RAG1_HUMAN	recombination activating gene 1	198	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|liver(1)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|urinary_tract(1)	65	all_lung(20;0.226)	all_hematologic(20;0.107)				TACTTCCCGAGGAACGTGACC	0.547000									Familial Hemophagocytic Lymphohistiocytosis				15	142					0	0	0.539581	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	42					0	0	0.115264	0	0
SCAF11	9169	broad.mit.edu	37	12	46321196	46321196	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr12:46321196G>A	ENST00000465950.1	-	1	2552	c.1343C>T	c.(1342-1344)gCg>gTg	p.A448V	SCAF11_ENST00000549162.1_Missense_Mutation_p.A571V|SCAF11_ENST00000419565.2_Missense_Mutation_p.A763V|SCAF11_ENST00000369367.3_Missense_Mutation_p.A763V			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	763					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						CTTTTCATCCGCAAGATCAGA	0.358000													6	470					0	0	0.217242	0	0
TRMT13	54482	broad.mit.edu	37	1	100606469	100606469	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr1:100606469A>G	ENST00000370141.2	+	7	569	c.563A>G	c.(562-564)gAg>gGg	p.E188G		NM_019083.2	NP_061956.2			tRNA methyltransferase 13 homolog (S. cerevisiae)																		TGCTTTGTTGAGTTTGGAGCG	0.343000													3	134					0	0	0.115264	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401104	11401104	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr4:11401104C>T	ENST00000002596.5	-	2	1700	c.526G>A	c.(526-528)Gag>Aag	p.E176K		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	176						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						ACCAGGAACTCCTCGATGGAC	0.587000													7	49					0	0	0.278610	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													5	41					0	0	0.184627	0	0
NIPAL1	152519	broad.mit.edu	37	4	48027238	48027238	+	Missense_Mutation	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr4:48027238G>A	ENST00000295461.5	+	2	266	c.200G>A	c.(199-201)aGt>aAt	p.S67N	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	67						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						AACAAATACAGTCTTTATGTG	0.443000													6	297					0	0	0.278610	0	0
TTC37	9652	broad.mit.edu	37	5	94838675	94838675	+	Missense_Mutation	SNP	C	C	G			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr5:94838675C>G	ENST00000358746.2	-	32	3548	c.3250G>C	c.(3250-3252)Gag>Cag	p.E1084Q		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1084							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						TTGTCTTGCTCCGATTCAACA	0.363000													7	94					0	0	0.278610	0	0
RUNX1T1	862	broad.mit.edu	37	8	93088224	93088224	+	Silent	SNP	G	G	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr8:93088224G>A	ENST00000523629.1	-	2	511	c.57C>T	c.(55-57)tgC>tgT	p.C19C	RUNX1T1_ENST00000522163.1_5'UTR|RUNX1T1_ENST00000360348.2_Intron|RUNX1T1_ENST00000518844.1_5'UTR|RUNX1T1_ENST00000520724.1_Intron|RUNX1T1_ENST00000436581.2_Intron|RUNX1T1_ENST00000265814.3_Silent_p.C19C	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	19					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CTTTTTTCCGGCAGTCACCTA	0.358000													8	809					0	0	0.335167	0	0
SORBS2	8470	broad.mit.edu	37	4	186539747	186539747	+	Silent	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr4:186539747C>T	ENST00000431808.1	-	16	3194	c.2631G>A	c.(2629-2631)caG>caA	p.Q877Q	SORBS2_ENST00000284776.7_Silent_p.Q877Q|SORBS2_ENST00000449407.2_Silent_p.Q421Q|SORBS2_ENST00000448662.2_Silent_p.Q438Q|SORBS2_ENST00000498125.1_5'UTR|SORBS2_ENST00000393528.3_Silent_p.Q443Q|SORBS2_ENST00000355634.5_Silent_p.Q977Q|SORBS2_ENST00000437304.2_Silent_p.Q601Q|SORBS2_ENST00000319471.9_Silent_p.Q508Q|SORBS2_ENST00000418609.1_Silent_p.Q781Q			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	877	SH3 1.					actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		ACTTAGATGTCTGAGCCTTAA	0.289000													3	46					0	0	0.115264	0	0
FRYL	285527	broad.mit.edu	37	4	48622719	48622719	+	Missense_Mutation	SNP	C	C	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr4:48622719C>T	ENST00000358350.4	-	6	855	c.251G>A	c.(250-252)cGc>cAc	p.R84H	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507711.1_Missense_Mutation_p.R84H|FRYL_ENST00000503238.1_Missense_Mutation_p.R84H|FRYL_ENST00000537810.1_Missense_Mutation_p.R84H	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	84					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						TCCATTTTGGCGTCTGTACCA	0.418000													6	317					0	0	0.217242	0	0
NBPF10	100132406	broad.mit.edu	37	1	145327548	145327548	+	Missense_Mutation	SNP	A	A	G			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr1:145327548A>G	ENST00000342960.5	+	32	4140	c.4105A>G	c.(4105-4107)Aat>Gat	p.N1369D	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	1369										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		GGACTCACTGAATAGATGTTA	0.473000													4	13					0	0	0.150653	0	0
TTLL10	254173	broad.mit.edu	37	1	1116222	1116223	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr1:1116222_1116223insG	ENST00000379290.1	+	8	910_911	c.737_738insG	c.(736-738)cggfs	p.R246fs	TTLL10_ENST00000379288.3_Frame_Shift_Ins_p.R173fs|TTLL10_ENST00000379289.1_Frame_Shift_Ins_p.R246fs			Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	246	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(2)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		AGCAAGGTGCCGGGGGGGGTCC	0.723													2	4	---	---	---	---					
ANKRD20A12P	100874392	broad.mit.edu	37	1	142720897	142720898	+	RNA	INS	-	-	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr1:142720897_142720898insA	ENST00000595144.1	-	0	204_205																											GCTCTTCCTCTAAGCCACTGGT	0.277													8	40	---	---	---	---					
ROBO2	6092	broad.mit.edu	37	3	77595587	77595588	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr3:77595587_77595588insT	ENST00000461745.1	+	7	1933_1934	c.1033_1034insT	c.(1033-1035)tttfs	p.F345fs	ROBO2_ENST00000332191.8_Frame_Shift_Ins_p.F345fs|ROBO2_ENST00000487694.3_Frame_Shift_Ins_p.F361fs	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	345	Ig-like C2-type 4.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		ACAGCCAGCTGTTTTTTGGCAG	0.485													7	1076	---	---	---	---					
TNFRSF21	27242	broad.mit.edu	37	6	47253988	47253989	+	Frame_Shift_Ins	INS	-	-	G			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr6:47253988_47253989insG	ENST00000296861.2	-	2	832_833	c.439_440insC	c.(439-441)tacfs	p.Y147fs		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	147					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			ACACACCGTATGGGGGGCACAG	0.554													8	533	---	---	---	---					
CBLL1	79872	broad.mit.edu	37	7	107395909	107395909	+	Frame_Shift_Del	DEL	A	A	-			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr7:107395909delA	ENST00000440859.2	+	5	880	c.413delA	c.(412-414)gafs	p.E138fs	CBLL1_ENST00000222597.2_Frame_Shift_Del_p.E137fs|CBLL1_ENST00000415884.2_Intron	NM_024814.2	NP_079090.2	Q75N03	HAKAI_HUMAN	Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase	138					cell-cell adhesion|negative regulation of cell adhesion|positive regulation of cell migration|positive regulation of endocytosis		protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(3)	21						ATTTTACATGAAAAAAAGGGA	0.269													7	323	---	---	---	---					
TAF2	6873	broad.mit.edu	37	8	120801888	120801889	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr8:120801888_120801889insA	ENST00000378164.2	-	12	1809_1810	c.1511_1512insT	c.(1510-1512)taafs	p.*504fs		NM_003184.3	NP_003175.1	Q6P1X5	TAF2_HUMAN	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	504					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			NS(2)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(21)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	49	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			AAATGGATTTCAAAAACCCAGA	0.406													7	548	---	---	---	---					
TXNRD1	7296	broad.mit.edu	37	12	104651847	104651848	+	Frame_Shift_Ins	INS	-	-	A			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr12:104651847_104651848insA	ENST00000525566.1	+	3	318_319	c.294_295insA	c.(292-297)ctatcafs	p.S99fs	TXNRD1_ENST00000429002.2_Frame_Shift_Ins_p.S99fs|TXNRD1_ENST00000526006.1_3'UTR	NM_001093771.2	NP_001087240.1	Q16881	TRXR1_HUMAN	thioredoxin reductase 1	99	Glutaredoxin.				cell redox homeostasis|cellular lipid metabolic process|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|signal transduction|transport	cytosol|nucleolus	electron carrier activity|flavin adenine dinucleotide binding|NADP binding|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|stomach(1)|urinary_tract(1)	16						TGCTTGAACTTGATCAAACAGG	0.317													3	6	---	---	---	---					
FAM101A	144347	broad.mit.edu	37	12	124719609	124719610	+	RNA	INS	-	-	CATTAA			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr12:124719609_124719610insCATTAA	ENST00000540762.1	+	0	444																											accatcaccatcaccatcacca	0.485													3	4	---	---	---	---					
STRN3	29966	broad.mit.edu	37	14	31381228	31381229	+	Frame_Shift_Ins	INS	-	-	T			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr14:31381228_31381229insT	ENST00000355683.5	-	9	1497_1498	c.1282_1283insA	c.(1282-1284)agtfs	p.S428fs	STRN3_ENST00000357479.5_Frame_Shift_Ins_p.S512fs	NM_014574.3	NP_055389.3	Q13033	STRN3_HUMAN	striatin, calmodulin binding protein 3	458					negative regulation of estrogen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|response to estradiol stimulus	cytoplasm|dendrite|Golgi apparatus|neuronal cell body|nucleoplasm|nucleus|plasma membrane|protein complex	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.0124)		GGCAGGAACTGTTTTTTGCAGG	0.381													8	718	---	---	---	---					
RP6-114E22.1	0	broad.mit.edu	37	14	72352549	72352569	+	RNA	DEL	CTGTTTAATACTAGTGGAAAG	CTGTTTAATACTAGTGGAAAG	-			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr14:72352549_72352569delCTGTTTAATACTAGTGGAAAG	ENST00000555581.1	+	0	131																											GTGTCTCTCTCTGTTTAATACTAGTGGAAAGCTGTTTAATA	0.398													2	4	---	---	---	---					
PRRT2	112476	broad.mit.edu	37	16	29825015	29825016	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr16:29825015_29825016insC	ENST00000300797.6	+	2	814_815	c.640_641insC	c.(640-642)cccfs	p.P214fs	PRRT2_ENST00000567659.1_Frame_Shift_Ins_p.P214fs|AC009133.20_ENST00000569039.1_RNA|PRRT2_ENST00000567551.1_3'UTR|PRRT2_ENST00000358758.7_Frame_Shift_Ins_p.P214fs			Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	214	Pro-rich.			A -> AP (in Ref. 3; CAD38881).	response to biotic stimulus	integral to membrane		p.R217fs*12(1)|p.A214P(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						AGCCAATGGGGCCCCCCCCCGA	0.653													4	6	---	---	---	---					
KRT24	192666	broad.mit.edu	37	17	38859835	38859836	+	Frame_Shift_Ins	INS	-	-	C			TCGA-17-Z054-01A-01W-0747-08	TCGA-17-Z054-11A-01W-0747-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	409dd077-dab9-4f79-9c33-2c3b75b63125	6db595af-e34b-4058-95e5-0e95821e0f4a	g.chr17:38859835_38859836insC	ENST00000264651.2	-	1	166_167	c.110_111insG	c.(109-111)gagfs	p.E37fs		NM_019016.2	NP_061889.2	Q2M2I5	K1C24_HUMAN	keratin 24	37	Gly-rich.|Head.					cytoplasm|intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Breast(137;0.00526)				GGGCCGAGCTGCCCCCCAGACC	0.658													7	129	---	---	---	---					
