Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NAGLU	4669	broad.mit.edu	37	17	40690472	40690472	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:40690472C>T	ENST00000225927.2	+	3	748	c.647C>T	c.(646-648)cCc>cTc	p.P216L	RP11-400F19.8_ENST00000585572.1_RNA	NM_000263.3	NP_000254.2	P54802	ANAG_HUMAN	N-acetylglucosaminidase, alpha	216						lysosome	alpha-N-acetylglucosaminidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	12		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CCCCTGCCCCCCTCCTGGCAC	0.582000													10	119					0	0	0.361761	0	0
METTL18	92342	broad.mit.edu	37	1	169762232	169762232	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:169762232C>G	ENST00000310392.4	-	2	958	c.605G>C	c.(604-606)gGt>gCt	p.G202A	METTL18_ENST00000303469.2_Missense_Mutation_p.G202A|C1orf112_ENST00000498289.1_Intron	NM_033418.2	NP_219486.1	O95568	MET18_HUMAN	methyltransferase like 18	202						cytoplasm	protein methyltransferase activity			kidney(1)|large_intestine(3)|lung(4)	8						TGCAGTTATACCTAGTAAACC	0.393000													20	147					0	0	0.624587	0	0
TMX3	54495	broad.mit.edu	37	18	66365215	66365215	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:66365215C>G	ENST00000299608.2	-	7	762	c.446G>C	c.(445-447)aGa>aCa	p.R149T	TMX3_ENST00000443099.2_Missense_Mutation_p.R122T|TMX3_ENST00000562706.1_Missense_Mutation_p.R149T	NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	149					cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						TACACGGTGTCTCTTCTGCAT	0.318000													7	12					0	0	0.307466	0	0
KEAP1	9817	broad.mit.edu	37	19	10597495	10597495	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:10597495C>A	ENST00000171111.5	-	6	2256		c.e6-1		KEAP1_ENST00000393623.2_Splice_Site	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TCATAGCCTCCTGCGGGAAGA	0.567000													28	18					2.79863e-10	3.86979e-10	0.681144	1	0
NKAPL	222698	broad.mit.edu	37	6	28227392	28227392	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:28227392C>T	ENST00000343684.3	+	1	295	c.243C>T	c.(241-243)taC>taT	p.Y81Y		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	81								p.Y81Y(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						TCCGCAACTACGCCTTCGCGT	0.587000													7	67					0	0	0.248553	0	0
CDX2	1045	broad.mit.edu	37	13	28537312	28537312	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:28537312G>T	ENST00000381020.7	-	3	3014	c.882C>A	c.(880-882)ggC>ggA	p.G294G	CDX2_ENST00000548877.1_5'UTR	NM_001265.4	NP_001256.3	Q99626	CDX2_HUMAN	caudal type homeobox 2	294					organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(6)	9	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		CAGGGACAGAGCCAGGCACTG	0.657000			T	ETV6	AML								12	17					4.3838e-07	5.47975e-07	0.435327	1	0
LAMB1	3912	broad.mit.edu	37	7	107599871	107599871	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:107599871C>A	ENST00000393561.1	-	18	2769	c.2585G>T	c.(2584-2586)gGc>gTc	p.G862V	LAMB1_ENST00000222399.6_Missense_Mutation_p.G838V			P07942	LAMB1_HUMAN	laminin, beta 1	838	Laminin EGF-like 7.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGGCACTGGCCAGTGACGGG	0.532000													24	22					9.57634e-11	1.33897e-10	0.654019	1	0
A1CF	29974	broad.mit.edu	37	10	52575818	52575818	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:52575818G>T	ENST00000395489.2	-	11	1464	c.1068C>A	c.(1066-1068)gcC>gcA	p.A356A	A1CF_ENST00000374001.1_Silent_p.A363A|A1CF_ENST00000373993.1_Silent_p.A363A|ASAH2B_ENST00000483649.1_3'UTR|A1CF_ENST00000373995.3_Silent_p.A371A|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000373997.3_Silent_p.A363A|A1CF_ENST00000282641.2_Silent_p.A363A|A1CF_ENST00000395495.1_Silent_p.A308A	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	363					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GTCCTTTGGTGGCTGGGAAAT	0.483000													34	78					7.04047e-22	1.2223e-21	0.812448	1	0
IPMK	253430	broad.mit.edu	37	10	59956160	59956160	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:59956160C>A	ENST00000373935.3	-	6	1250	c.928G>T	c.(928-930)Gtg>Ttg	p.V310L		NM_152230.4	NP_689416.1	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	310						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)	22						CTTTTGCCCACTGAAGACTCT	0.373000													36	110					6.84511e-11	9.63557e-11	0.779181	1	0
SLC7A13	157724	broad.mit.edu	37	8	87226715	87226715	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:87226715G>T	ENST00000297524.3	-	4	1443	c.1340C>A	c.(1339-1341)gCt>gAt	p.A447D	SLC7A13_ENST00000419776.2_3'UTR	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	447						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						CTCAAACCAAGCCAATCTTAT	0.333000													18	16					2.39187e-15	3.78461e-15	0.575678	1	0
TRAV5	28688	broad.mit.edu	37	14	22217518	22217518	+	RNA	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:22217518G>T	ENST00000390427.3	+	0	57																											TGTGGCTGCAGCTGGACTGTG	0.448000													51	256					2.41709e-19	4.1163e-19	0.870114	1	0
PTPRJ	5795	broad.mit.edu	37	11	48186005	48186005	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:48186005G>T	ENST00000418331.2	+	24	4145	c.3793G>T	c.(3793-3795)Gtg>Ttg	p.V1265L		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1265	Tyrosine-protein phosphatase.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TGAGAACACCGTGGATGTGTA	0.468000													21	34					3.5997e-14	5.52779e-14	0.624587	1	0
NOX4	50507	broad.mit.edu	37	11	89133461	89133461	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:89133461G>T	ENST00000535633.1	-	10	1171	c.861C>A	c.(859-861)atC>atA	p.I287I	NOX4_ENST00000413594.2_Silent_p.I332I|NOX4_ENST00000542487.1_Silent_p.I287I|NOX4_ENST00000528341.1_Silent_p.I286I|NOX4_ENST00000424319.1_Silent_p.I287I|NOX4_ENST00000527956.1_Silent_p.I287I|NOX4_ENST00000527626.1_Silent_p.I145I|NOX4_ENST00000525196.1_Intron|NOX4_ENST00000263317.4_Silent_p.I311I|NOX4_ENST00000343727.5_Silent_p.I287I|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000534731.1_Silent_p.I311I|NOX4_ENST00000532825.1_Silent_p.I287I	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	311	Ferric oxidoreductase.|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				TGACCGAAATGATGGTGACTG	0.433000													10	81					3.86212e-05	4.45355e-05	0.361761	1	0
NBPF10	100132406	broad.mit.edu	37	1	145368636	145368636	+	Silent	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:145368636G>C	ENST00000342960.5	+	84	10649	c.10614G>C	c.(10612-10614)gtG>gtC	p.V3538V	NBPF10_ENST00000369338.1_Silent_p.V654V|NBPF10_ENST00000369339.2_Silent_p.V656V	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3538										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CTTTGACGGTGACAAGTCTCC	0.468000													112	248					0	0	0.870114	0	0
ATP8A2	51761	broad.mit.edu	37	13	26116075	26116075	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:26116075G>T	ENST00000381655.2	+	9	812	c.670G>T	c.(670-672)Gac>Tac	p.D224Y	ATP8A2_ENST00000255283.8_Missense_Mutation_p.D184Y	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	184					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TCACACTGCTGACATGCAAAC	0.423000													27	29					2.24059e-21	3.84717e-21	0.706142	1	0
COL12A1	1303	broad.mit.edu	37	6	75890796	75890796	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:75890796C>A	ENST00000322507.8	-	11	2332	c.2023G>T	c.(2023-2025)Gtc>Ttc	p.V675F	COL12A1_ENST00000345356.6_Intron|COL12A1_ENST00000483888.2_Missense_Mutation_p.V675F|COL12A1_ENST00000416123.2_Missense_Mutation_p.V675F	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	675	Fibronectin type-III 3.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ACCACAGTGACCTCATCATCC	0.483000													76	26					2.14232e-31	3.90365e-31	0.870114	1	0
ZKSCAN2	342357	broad.mit.edu	37	16	25258513	25258513	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:25258513T>C	ENST00000328086.7	-	5	1807	c.1004A>G	c.(1003-1005)gAt>gGt	p.D335G		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	335					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		TATCTTTTCATCTTCTAAACC	0.463000													12	87					0	0	0.387290	0	0
TXLNB	167838	broad.mit.edu	37	6	139583811	139583811	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:139583811G>T	ENST00000358430.3	-	5	1019	c.787C>A	c.(787-789)Cag>Aag	p.Q263K		NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	263						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TCACTCTGCTGCTCGATCTGG	0.512000													24	92					1.77063e-15	2.81589e-15	0.693898	1	0
IGHMBP2	3508	broad.mit.edu	37	11	68703722	68703722	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:68703722G>T	ENST00000255078.3	+	13	1885	c.1774G>T	c.(1774-1776)Gct>Tct	p.A592S	IGHMBP2_ENST00000541229.1_3'UTR	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	592					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGGTTTTCTTGCTGAGGACCG	0.532000													26	82					1.55469e-16	2.53703e-16	0.654019	1	0
GRID2	2895	broad.mit.edu	37	4	94316766	94316766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:94316766C>A	ENST00000282020.4	+	9	1512	c.1254C>A	c.(1252-1254)tgC>tgA	p.C418*	GRID2_ENST00000510992.1_Nonsense_Mutation_p.C323*	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	418					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGCTTGGTTGCTGGAATCCTG	0.423000													24	25					1.77063e-15	2.81589e-15	0.693898	1	0
BIRC8	112401	broad.mit.edu	37	19	53793012	53793012	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:53793012G>A	ENST00000426466.1	-	1	1863	c.616C>T	c.(616-618)Cat>Tat	p.H206Y		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	206					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		GTGACCAGATGTCCACAAGGA	0.423000													15	76					0	0	0.520397	0	0
GOLGA4	2803	broad.mit.edu	37	3	37366780	37366780	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:37366780C>T	ENST00000361924.2	+	14	3777	c.3403C>T	c.(3403-3405)Cat>Tat	p.H1135Y	GOLGA4_ENST00000356847.4_Missense_Mutation_p.H1157Y|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1135	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						ACTGAAAGCTCATCTTGAAAA	0.368000													27	20					0	0	0.693898	0	0
ANKRD20A11P	391267	broad.mit.edu	37	21	15323433	15323433	+	RNA	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr21:15323433C>T	ENST00000344693.5	-	0	877					NR_027270.1																						GCTCCTTTCACAGCAGGATCT	0.323000													3	36					0	0	0.248553	0	0
YIF1B	90522	broad.mit.edu	37	19	38798252	38798252	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:38798252C>A	ENST00000392124.3	-	5	901	c.587G>T	c.(586-588)gGc>gTc	p.G196V	YIF1B_ENST00000592246.1_Missense_Mutation_p.G161V|YIF1B_ENST00000329420.8_Missense_Mutation_p.G212V|YIF1B_ENST00000337679.8_Missense_Mutation_p.G224V|YIF1B_ENST00000339413.6_Missense_Mutation_p.G227V|YIF1B_ENST00000592694.1_Missense_Mutation_p.G196V|YIF1B_ENST00000591784.1_Missense_Mutation_p.G196V|YIF1B_ENST00000591755.1_Missense_Mutation_p.G224V	NM_033557.3	NP_291035.1	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B (S. cerevisiae)	227						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)	10	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ATATTTGTAGCCCAAGAAGGC	0.627000													5	51					5.9392e-07	7.40918e-07	0.217242	1	0
DEDD2	162989	broad.mit.edu	37	19	42713942	42713942	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:42713942C>A	ENST00000595337.1	-	4	586	c.499G>T	c.(499-501)Ggt>Tgt	p.G167C	DEDD2_ENST00000598727.1_Missense_Mutation_p.G167C|DEDD2_ENST00000336034.4_Missense_Mutation_p.G162C|DEDD2_ENST00000596251.1_Missense_Mutation_p.G167C|DEDD2_ENST00000593804.1_5'UTR	NM_001270614.1	NP_001257543.1	Q8WXF8	DEDD2_HUMAN	death effector domain containing 2	167					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(2)	5		Prostate(69;0.0704)				CGTCTGGCACCACCACTGGGC	0.657000													33	23					2.80507e-11	4.02103e-11	0.760397	1	0
EVI5	7813	broad.mit.edu	37	1	92979323	92979323	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:92979323C>T	ENST00000370331.1	-	18	2332	c.2323G>A	c.(2323-2325)Ggt>Agt	p.G775S	EVI5_ENST00000543509.1_Missense_Mutation_p.G786S|EVI5_ENST00000540033.1_Missense_Mutation_p.G775S	NM_005665.4	NP_005656.4	O60447	EVI5_HUMAN	ecotropic viral integration site 5	775	Interaction with AURKB and INCENP.|Targeting to the centrosomes.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|skin(1)	38		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		CTCTCACTACCATCTGCCACT	0.478000													31	47					0	0	0.760397	0	0
ANAPC1	64682	broad.mit.edu	37	2	112605391	112605391	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:112605391C>T	ENST00000341068.3	-	15	2474	c.1702G>A	c.(1702-1704)Gat>Aat	p.D568N		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	568					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						TAGAGAGAATCATGAAGTTTT	0.358000													8	86					0	0	0.278610	0	0
MYO7B	4648	broad.mit.edu	37	2	128390907	128390907	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:128390907A>G	ENST00000389524.4	+	39	5458	c.5405A>G	c.(5404-5406)cAc>cGc	p.H1802R	MYO7B_ENST00000409816.2_Missense_Mutation_p.H1801R|MYO7B_ENST00000428314.1_Missense_Mutation_p.H1801R|MYO7B_ENST00000409090.1_Missense_Mutation_p.H654R			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1801	FERM 2.|MyTH4 3.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGCATCTGCCACAAGATCTAC	0.657000													3	22					0	0	0.150653	0	0
NAV3	89795	broad.mit.edu	37	12	78443877	78443877	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:78443877C>G	ENST00000397909.2	+	10	2301	c.2128C>G	c.(2128-2130)Cac>Gac	p.H710D	NAV3_ENST00000266692.7_Missense_Mutation_p.H710D|NAV3_ENST00000536525.2_Missense_Mutation_p.H710D|NAV3_ENST00000228327.6_Missense_Mutation_p.H710D			Q8IVL0	NAV3_HUMAN	neuron navigator 3	710						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCAGATAAGCCACAGGTTTTT	0.333000										HNSCC(70;0.22)			12	23					0	0	0.411799	0	0
ASAH2	56624	broad.mit.edu	37	10	52008320	52008320	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:52008320A>T	ENST00000395526.3	-	1	50	c.51T>A	c.(49-51)ctT>ctA	p.L17L	ASAH2_ENST00000447815.1_Silent_p.L17L	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	17					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(1)|lung(9)|urinary_tract(1)	11						TCATCATTACAAGGAGGAAAA	0.453000													5	54					0	0	0.217242	0	0
DPT	1805	broad.mit.edu	37	1	168670315	168670315	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:168670315A>G	ENST00000367817.3	-	3	568	c.479T>C	c.(478-480)aTt>aCt	p.I160T		NM_001937.4	NP_001928.2	Q07507	DERM_HUMAN	dermatopontin	160	2 X 53-55 AA tandem repeats.|3 X 6 AA repeats of D-R-[EQ]-W-[NQK]- [FY].				cell adhesion	extracellular space|proteinaceous extracellular matrix				kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					ATTGTAGGAAATCATGTCCAT	0.418000													14	151					0	0	0.479597	0	0
C14orf159	80017	broad.mit.edu	37	14	91655475	91655475	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:91655475A>G	ENST00000518868.1	+	12	1846	c.1156A>G	c.(1156-1158)Aac>Gac	p.N386D	C14orf159_ENST00000521077.2_Missense_Mutation_p.N386D|C14orf159_ENST00000520328.1_Missense_Mutation_p.N369D|C14orf159_ENST00000428926.2_Missense_Mutation_p.N381D|C14orf159_ENST00000523816.1_Missense_Mutation_p.N381D|C14orf159_ENST00000523771.1_Missense_Mutation_p.N381D|C14orf159_ENST00000525393.2_Missense_Mutation_p.N257D|C14orf159_ENST00000256324.10_Missense_Mutation_p.N386D|C14orf159_ENST00000412671.2_Missense_Mutation_p.N386D|C14orf159_ENST00000522322.1_Missense_Mutation_p.N381D			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	381						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		GAGAGCCTGGAACTTGCACCA	0.547000													4	26					0	0	0.217242	0	0
ST3GAL1	6482	broad.mit.edu	37	8	134472055	134472055	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:134472055C>A	ENST00000319914.5	-	9	2002	c.975G>T	c.(973-975)acG>acT	p.T325T	ST3GAL1_ENST00000399640.2_Silent_p.T325T|ST3GAL1_ENST00000522652.1_Silent_p.T325T|ST3GAL1_ENST00000521180.1_Silent_p.T325T			Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	325					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(3)|large_intestine(2)|lung(11)|prostate(1)	17	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			CCAAGGTGGCCGTCACGTTAG	0.562000													166	54					2.62042e-76	4.97801e-76	0.870114	1	0
CACNA1I	8911	broad.mit.edu	37	22	40078529	40078529	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:40078529G>T	ENST00000336649.4	+	38	5711	c.5711G>T	c.(5710-5712)cGt>cTt	p.R1904L	CACNA1I_ENST00000407673.1_Missense_Mutation_p.R1863L|CACNA1I_ENST00000401624.1_Missense_Mutation_p.R1898L|CACNA1I_ENST00000404898.1_Missense_Mutation_p.R1863L|CACNA1I_ENST00000402142.3_Missense_Mutation_p.R1898L|CACNA1I_ENST00000400164.3_Missense_Mutation_p.R1863L			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1898					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GAGCCCATGCGTGTGGGAGAC	0.592000													18	70					9.95505e-16	1.60358e-15	0.624587	1	0
C16orf3	750	broad.mit.edu	37	16	90095616	90095616	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:90095616G>T	ENST00000408886.2	-	1	693	c.135C>A	c.(133-135)gcC>gcA	p.A45A	GAS8_ENST00000540721.1_Intron|GAS8_ENST00000536122.1_Intron|GAS8_ENST00000268699.4_Intron	NM_001214.3	NP_001205.3	O95177	CP003_HUMAN	chromosome 16 open reading frame 3	45										large_intestine(1)|lung(2)|prostate(1)	4		all_cancers(9;9.01e-08)|Hepatocellular(780;0.000325)|Lung NSC(15;0.0104)|all_lung(18;0.0239)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		ctacggggcaggctacggggc	0.672000													6	15					8.12818e-05	9.2534e-05	0.248553	1	0
ATP2B2	491	broad.mit.edu	37	3	10392234	10392234	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:10392234G>T	ENST00000397077.1	-	14	2604	c.2029C>A	c.(2029-2031)Cgg>Agg	p.R677R	ATP2B2_ENST00000360273.2_Silent_p.R722R|ATP2B2_ENST00000383800.4_Silent_p.R677R|ATP2B2_ENST00000352432.4_Silent_p.R722R|ATP2B2_ENST00000343816.4_Silent_p.R708R			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	722					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						ATGCCTGCCCGCTGGCACTTG	0.632000													6	35					0.217242	0.221134	0.217242	1	0
ARHGEF10	9639	broad.mit.edu	37	8	1877563	1877563	+	Silent	SNP	C	C	T	rs144293528		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:1877563C>T	ENST00000518288.1	+	26	3268	c.3105C>T	c.(3103-3105)taC>taT	p.Y1035Y	ARHGEF10_ENST00000349830.3_Silent_p.Y1011Y|ARHGEF10_ENST00000520359.1_Silent_p.Y973Y|ARHGEF10_ENST00000398564.1_Silent_p.Y1036Y|ARHGEF10_ENST00000262112.6_Silent_p.Y1007Y			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	1036					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		AGAGCCTGTACGCTGGCCTGG	0.592000													6	63					0	0	0.217242	0	0
EDIL3	10085	broad.mit.edu	37	5	83549941	83549941	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:83549941C>A	ENST00000296591.5	-	2	575	c.157G>T	c.(157-159)Ggc>Tgc	p.G53C	EDIL3_ENST00000380138.3_Missense_Mutation_p.G53C	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	53	EGF-like 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TCTGTGAAGCCATCTGGACAC	0.398000													11	29					5.50884e-06	6.55814e-06	0.411799	1	0
TSPEAR	54084	broad.mit.edu	37	21	45948417	45948417	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr21:45948417C>T	ENST00000323084.4	-	6	905	c.840G>A	c.(838-840)gtG>gtA	p.V280V	TSPEAR_ENST00000397916.1_Silent_p.V212V	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	280					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						GGGCGTCTTCCACCTCGGTAC	0.592000													19	48					0	0	0.539581	0	0
HK2	3099	broad.mit.edu	37	2	75113632	75113632	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:75113632C>T	ENST00000290573.2	+	15	2651	c.2051C>T	c.(2050-2052)gCc>gTc	p.A684V	HK2_ENST00000409174.1_Missense_Mutation_p.A656V	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	684	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						GGCAGCAATGCCTGCTACATG	0.592000													14	56					0	0	0.457914	0	0
NAV3	89795	broad.mit.edu	37	12	78444840	78444840	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:78444840A>G	ENST00000397909.2	+	11	2602	c.2429A>G	c.(2428-2430)gAc>gGc	p.D810G	NAV3_ENST00000266692.7_Missense_Mutation_p.D810G|NAV3_ENST00000536525.2_Missense_Mutation_p.D810G|NAV3_ENST00000228327.6_Missense_Mutation_p.D810G			Q8IVL0	NAV3_HUMAN	neuron navigator 3	810						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AGTGACCTGGACATGTCTTCT	0.488000										HNSCC(70;0.22)			7	38					0	0	0.248553	0	0
OOSP2	219990	broad.mit.edu	37	11	59812143	59812143	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:59812143G>T	ENST00000278855.2	+	3	428		c.e3-1		PLAC1L_ENST00000532905.1_Splice_Site	NM_173801.3	NP_776162.2	Q86WS3	PLACL_HUMAN								extracellular region				breast(1)|lung(9)|ovary(2)|prostate(2)|skin(1)	15						TGCTCTCCTAGGTAGTTTCTG	0.393000													29	26					9.39395e-14	1.432e-13	0.706142	1	0
PLCL1	5334	broad.mit.edu	37	2	198950287	198950287	+	Silent	SNP	G	G	T	rs144487956	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:198950287G>T	ENST00000428675.1	+	2	2444	c.2046G>T	c.(2044-2046)acG>acT	p.T682T	PLCL1_ENST00000437704.2_Silent_p.T584T	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	682	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity	p.T682T(1)|p.T584T(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	ACCTTCACACGGGCTGGTTTC	0.443000													31	59					2.20262e-25	3.92205e-25	0.769981	1	0
OR4N4	283694	broad.mit.edu	37	15	22382684	22382684	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:22382684C>A	ENST00000328795.4	+	1	303	c.212C>A	c.(211-213)gCa>gAa	p.A71E	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTCCTGGATGCATCCTACTCC	0.478000													28	222					5.44703e-19	9.20106e-19	0.847076	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319715	21319715	+	Missense_Mutation	SNP	C	C	A	rs140886918	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:21319715C>A	ENST00000583088.1	+	3	1956	c.1061C>A	c.(1060-1062)aCg>aAg	p.T354K	KCNJ12_ENST00000331718.5_Missense_Mutation_p.T354K	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.T354M(1)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GTGCCCTCTACGCCCCGCTGC	0.572000										Prostate(3;0.18)			22	110					2.89027e-11	4.13368e-11	0.624587	1	0
NEU4	129807	broad.mit.edu	37	2	242758149	242758149	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:242758149G>T	ENST00000391969.2	+	5	1941	c.1230G>T	c.(1228-1230)tgG>tgT	p.W410C	NEU4_ENST00000325935.6_Missense_Mutation_p.W423C|NEU4_ENST00000407683.1_Missense_Mutation_p.W410C|NEU4_ENST00000405370.1_Missense_Mutation_p.W410C|NEU4_ENST00000404257.1_Missense_Mutation_p.W422C	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	410						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CAGAGCCCTGGGTGATCTACG	0.697000													4	6					0.00024832	0.000277143	0.150653	1	0
ANKRD34A	284615	broad.mit.edu	37	1	145474248	145474248	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:145474248G>T	ENST00000323397.4	+	4	2213	c.920G>T	c.(919-921)aGc>aTc	p.S307I		NM_001039888.2	NP_001034977.1	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34A	307	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	20	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAAGTGACTAGCGGGGGTCCT	0.632000													18	36					1.99824e-07	2.56975e-07	0.520397	1	0
MIR134	406924	broad.mit.edu	37	14	101521083	101521083	+	RNA	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:101521083A>T	ENST00000385258.2	+	0	76					NR_029698.1																						TGGGCCACCTAGTCACCAACC	0.587000													3	29					0	0	0.115264	0	0
GTDC1	79712	broad.mit.edu	37	2	144966278	144966278	+	Missense_Mutation	SNP	T	T	A	rs114787738	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:144966278T>A	ENST00000409214.1	-	4	349	c.71A>T	c.(70-72)gAg>gTg	p.E24V	GTDC1_ENST00000392867.3_Missense_Mutation_p.E24V|GTDC1_ENST00000392869.1_Missense_Mutation_p.E24V|GTDC1_ENST00000344850.4_Missense_Mutation_p.E24V|GTDC1_ENST00000542155.1_Missense_Mutation_p.E24V|GTDC1_ENST00000463875.2_Intron|GTDC1_ENST00000409298.1_Missense_Mutation_p.E24V|GTDC1_ENST00000241391.5_Missense_Mutation_p.E24V	NM_001006636.3	NP_001006637.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	24					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		GTCTCCTAACTCTTCTTGAAG	0.438000													8	79					0	0	0.335167	0	0
DSTYK	25778	broad.mit.edu	37	1	205131163	205131163	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:205131163C>A	ENST00000367162.3	-	6	1849		c.e6+1		DSTYK_ENST00000367160.4_Intron|DSTYK_ENST00000367161.3_Splice_Site	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase							cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						TACATACCAACCTGCCGCAAG	0.498000													4	21					0.150653	0.154611	0.150653	1	0
PHLDB2	90102	broad.mit.edu	37	3	111681059	111681059	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:111681059G>T	ENST00000431670.2	+	13	3388	c.2977G>T	c.(2977-2979)Gat>Tat	p.D993Y	PHLDB2_ENST00000393923.3_Missense_Mutation_p.D977Y|PHLDB2_ENST00000470699.2_3'UTR|PHLDB2_ENST00000393925.3_Missense_Mutation_p.D993Y|PHLDB2_ENST00000495180.1_Missense_Mutation_p.D484Y|PHLDB2_ENST00000481953.1_Missense_Mutation_p.D950Y|PHLDB2_ENST00000412622.1_Missense_Mutation_p.D950Y	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	993						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						CCATTATCCAGATCACAGCTA	0.438000													14	78					4.3838e-07	5.47975e-07	0.435327	1	0
ZNF221	7638	broad.mit.edu	37	19	44471441	44471441	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:44471441A>C	ENST00000251269.5	+	6	2115	c.1787A>C	c.(1786-1788)gAa>gCa	p.E596A	ZNF221_ENST00000587682.1_Missense_Mutation_p.E596A|ZNF221_ENST00000592350.1_Missense_Mutation_p.E596A	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				GGAGTGTGGGAAGAGATCTAC	0.433000													10	113					0	0	0.361761	0	0
DHX34	9704	broad.mit.edu	37	19	47876924	47876924	+	Silent	SNP	G	G	T	rs147516349		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:47876924G>T	ENST00000328771.4	+	9	2380	c.2031G>T	c.(2029-2031)ctG>ctT	p.L677L		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	677						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		AGCATCGACTGTACGAAATGG	0.617000													11	12					2.27111e-07	2.89092e-07	0.411799	1	0
GRIK4	2900	broad.mit.edu	37	11	120769328	120769328	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:120769328C>G	ENST00000527524.2	+	12	1539	c.1252C>G	c.(1252-1254)Ctg>Gtg	p.L418V	GRIK4_ENST00000438375.2_Missense_Mutation_p.L418V			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	418					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CAACACCACCCTGGTCGTCAC	0.622000													5	15					0	0	0.248553	0	0
CACNG5	27091	broad.mit.edu	37	17	64881046	64881046	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:64881046G>T	ENST00000169565.3	+	4	838	c.838G>T	c.(838-840)Gag>Tag	p.E280*	CACNG5_ENST00000307139.3_Intron|CACNG5_ENST00000533854.1_Intron			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	0					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CCAGCCAAGGGAGATGAGGCA	0.632000													10	41					2.80697e-09	3.78911e-09	0.387290	1	0
AGXT2	64902	broad.mit.edu	37	5	34998832	34998832	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:34998832C>A	ENST00000231420.6	-	14	1737	c.1537G>T	c.(1537-1539)Gct>Tct	p.A513S		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	513					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	TGTTACTTAGCTCTTCTTTCC	0.388000													4	53					0.014758	0.0155021	0.184627	1	0
CLIC2	1193	broad.mit.edu	37	X	154508586	154508586	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:154508586C>T	ENST00000369449.2	-	5	652	c.434G>A	c.(433-435)cGt>cAt	p.R145H	CLIC2_ENST00000465553.1_5'UTR	NM_001289.4	NP_001280.3	O15247	CLIC2_HUMAN	chloride intracellular channel 2	145	C-terminal.|GST C-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	voltage-gated chloride channel activity	p.R145H(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	18	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTCATCCAGACGCTTGAATTC	0.383000													5	53					0	0	0.184627	0	0
MUC5B	727897	broad.mit.edu	37	11	1256632	1256632	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:1256632C>A	ENST00000447027.1	+	23	2936	c.2878C>A	c.(2878-2880)Ctc>Atc	p.L960I	MUC5B_ENST00000529681.1_Missense_Mutation_p.L957I			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	957	VWFD 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGCCATCAAGCTCTTCGTGGA	0.647000													6	8					0.00116845	0.00127226	0.217242	1	0
PZP	5858	broad.mit.edu	37	12	9349607	9349607	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:9349607C>A	ENST00000261336.2	-	8	896		c.e8+1		PZP_ENST00000381997.2_Splice_Site	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						CGCCTACTAACCTGTTGACTG	0.453000													13	99					0.000219431	0.000247553	0.457914	1	0
PHF20L1	51105	broad.mit.edu	37	8	133855063	133855063	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:133855063C>A	ENST00000395386.2	+	19	2990	c.2691C>A	c.(2689-2691)caC>caA	p.H897Q	AF230666.2_ENST00000429151.1_RNA|PHF20L1_ENST00000395390.2_Missense_Mutation_p.H872Q|PHF20L1_ENST00000220847.7_Missense_Mutation_p.H284Q	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	897							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			AAGAATTCCACATGAGAAGTA	0.378000													113	39					3.3835e-51	6.40815e-51	0.870114	1	0
OR2L8	391190	broad.mit.edu	37	1	248112883	248112883	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:248112883A>T	ENST00000357191.3	+	1	724	c.724A>T	c.(724-726)Acc>Tcc	p.T242S	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GACCTGCAGCACCCACCTCAC	0.463000													34	132					0	0	0.760397	0	0
XIRP2	129446	broad.mit.edu	37	2	168114371	168114371	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:168114371G>T	ENST00000409728.1	+	11	1503	c.1414G>T	c.(1414-1416)Gga>Tga	p.G472*	XIRP2_ENST00000409605.1_Nonsense_Mutation_p.G217*|XIRP2_ENST00000420519.1_Nonsense_Mutation_p.G472*|XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409756.2_Nonsense_Mutation_p.G439*|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000409043.1_Nonsense_Mutation_p.G439*|XIRP2_ENST00000409195.1_3'UTR	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGGCAGTTTGGGAAATTATGC	0.318000													8	48					0.0477658	0.0496732	0.307466	1	0
RYR2	6262	broad.mit.edu	37	1	237730043	237730043	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:237730043G>T	ENST00000366574.2	+	28	3708	c.3391G>T	c.(3391-3393)Gat>Tat	p.D1131Y	RYR2_ENST00000542537.1_Missense_Mutation_p.D1115Y|RYR2_ENST00000360064.6_Missense_Mutation_p.D1129Y	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1131	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCTTGGCTCAGATGAACGTGC	0.537000													30	177					1.74807e-11	2.52903e-11	0.750413	1	0
AGPAT1	10554	broad.mit.edu	37	6	32137057	32137057	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:32137057C>A	ENST00000395499.1	-	7	1427	c.848G>T	c.(847-849)gGg>gTg	p.G283V	PPT2-EGFL8_ENST00000422437.1_Intron|AGPAT1_ENST00000375107.3_Missense_Mutation_p.G283V|AGPAT1_ENST00000395497.1_Missense_Mutation_p.G283V|AGPAT1_ENST00000395496.1_Missense_Mutation_p.G283V|AGPAT1_ENST00000490711.1_5'UTR|AGPAT1_ENST00000412465.2_Missense_Mutation_p.G171V|AGPAT1_ENST00000336984.6_Missense_Mutation_p.G283V|AGPAT1_ENST00000375104.2_Missense_Mutation_p.G283V			Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	283					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)|large_intestine(3)|lung(6)|ovary(2)	12						CAGGGTTCACCCACCGCCCCC	0.612000													15	44					1.3612e-06	1.66163e-06	0.479597	1	0
EWSR1	2130	broad.mit.edu	37	22	29695615	29695615	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:29695615G>T	ENST00000397938.2	+	16	2024	c.1705G>T	c.(1705-1707)Ggt>Tgt	p.G569C	EWSR1_ENST00000331029.7_Missense_Mutation_p.G531C|EWSR1_ENST00000406548.1_Missense_Mutation_p.G568C|EWSR1_ENST00000332050.6_Missense_Mutation_p.G496C|EWSR1_ENST00000414183.2_Missense_Mutation_p.G574C|EWSR1_ENST00000332035.6_Missense_Mutation_p.G513C	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	569	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGGTGGCCCTGGTGGCATGCG	0.622000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								6	22					0.00198382	0.00214513	0.248553	1	0
KIRREL2	84063	broad.mit.edu	37	19	36357308	36357308	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:36357308C>A	ENST00000360202.5	+	15	2239	c.2041C>A	c.(2041-2043)Ccc>Acc	p.P681T	KIRREL2_ENST00000347900.6_Intron|KIRREL2_ENST00000592409.1_Missense_Mutation_p.P646T|NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000586102.2_Missense_Mutation_p.P661T|KIRREL2_ENST00000262625.7_Intron	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	681	Pro-rich.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATCCTTTGGGCCCCCAGATCT	0.607000													46	128					2.24722e-20	3.83747e-20	0.870114	1	0
ASAP1	50807	broad.mit.edu	37	8	131092212	131092212	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:131092212C>A	ENST00000357668.1	-	25	2605	c.2578G>T	c.(2578-2580)Gat>Tat	p.D860Y	ASAP1_ENST00000518721.1_Missense_Mutation_p.D860Y			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	860	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						GGACCCCCATCGTTACCTACA	0.468000													13	198					0.00136819	0.00148717	0.411799	1	0
PCDH15	65217	broad.mit.edu	37	10	55912886	55912886	+	Silent	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:55912886C>G	ENST00000373965.2	-	15	2173	c.1779G>C	c.(1777-1779)gcG>gcC	p.A593A	PCDH15_ENST00000395438.1_Silent_p.A586A|PCDH15_ENST00000395446.1_Silent_p.A586A|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Silent_p.A586A|PCDH15_ENST00000320301.6_Silent_p.A586A|PCDH15_ENST00000395433.1_Silent_p.A564A|PCDH15_ENST00000395432.2_Silent_p.A549A|PCDH15_ENST00000409834.1_Silent_p.A197A|PCDH15_ENST00000437009.1_Silent_p.A586A|PCDH15_ENST00000361849.3_Silent_p.A586A|PCDH15_ENST00000414778.1_Silent_p.A591A|PCDH15_ENST00000395445.1_Silent_p.A593A|PCDH15_ENST00000373955.1_Silent_p.A586A|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000373957.3_Silent_p.A564A	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	586	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GAGCATTATCCGCTGCTTGGA	0.473000										HNSCC(58;0.16)			12	50					0	0	0.411799	0	0
MED13L	23389	broad.mit.edu	37	12	116424272	116424272	+	Silent	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:116424272C>G	ENST00000281928.3	-	19	4343	c.4137G>C	c.(4135-4137)ccG>ccC	p.P1379P		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1379					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent			p.P1379P(1)		NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GGATGGGCAACGGCTCAGGAG	0.473000													15	27					0	0	0.457914	0	0
CD36	948	broad.mit.edu	37	7	80303324	80303324	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:80303324C>A	ENST00000435819.1	+	17	1964	c.1280C>A	c.(1279-1281)gCa>gAa	p.A427E	CD36_ENST00000538969.1_Missense_Mutation_p.A367E|CD36_ENST00000447544.2_Missense_Mutation_p.A427E|CD36_ENST00000432207.1_Missense_Mutation_p.A427E|CD36_ENST00000544133.1_3'UTR|CD36_ENST00000534394.1_Missense_Mutation_p.A351E|CD36_ENST00000309881.7_Missense_Mutation_p.A427E|CD36_ENST00000394788.3_Missense_Mutation_p.A427E|CD36_ENST00000433696.2_Missense_Mutation_p.A388E			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	427					cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						GATGAGAAGGCAAACATGTTC	0.368000													3	26					0.115264	0.118878	0.115264	1	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727344	25727344	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:25727344G>A	ENST00000274764.2	+	1	208	c.208G>A	c.(208-210)Gat>Aat	p.D70N		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	70					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						CTTCGTCACTGATATCTTTGA	0.468000													12	71					0	0	0.457914	0	0
MORC1	27136	broad.mit.edu	37	3	108813842	108813842	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:108813842A>G	ENST00000232603.5	-	7	579	c.497T>C	c.(496-498)aTg>aCg	p.M166T	MORC1_ENST00000483760.1_Missense_Mutation_p.M166T	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	166					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AGATAATTCCATTGCAAATTT	0.323000													22	8					0	0	0.608945	0	0
CTNND2	1501	broad.mit.edu	37	5	11111032	11111032	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:11111032T>A	ENST00000304623.8	-	14	2590	c.2401A>T	c.(2401-2403)Aag>Tag	p.K801*	CTNND2_ENST00000359640.2_Nonsense_Mutation_p.K801*|CTNND2_ENST00000511377.1_Nonsense_Mutation_p.K710*|CTNND2_ENST00000458100.2_Nonsense_Mutation_p.K368*|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Nonsense_Mutation_p.K464*	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	801					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TCAGCATCCTTGCCATTGGCC	0.562000													97	167					0	0	0.870114	0	0
MDGA1	266727	broad.mit.edu	37	6	37606412	37606412	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:37606412G>T	ENST00000434837.2	-	15	3746	c.2568C>A	c.(2566-2568)aaC>aaA	p.N856K	MDGA1_ENST00000297153.7_Missense_Mutation_p.N860K|MDGA1_ENST00000505425.1_Missense_Mutation_p.N856K	NM_153487.3	NP_705691.1	Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	856	MAM.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						GAGCCCCTTTGTTCCGGGACC	0.622000													12	17					5.16669e-11	7.30583e-11	0.387290	1	0
CHL1	10752	broad.mit.edu	37	3	382570	382570	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:382570C>G	ENST00000256509.2	+	6	1121	c.479C>G	c.(478-480)cCa>cGa	p.P160R	CHL1_ENST00000397491.2_Missense_Mutation_p.P160R	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	160	Ig-like C2-type 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AAAGGCCTCCCACCTTTACAC	0.398000													17	23					0	0	0.520397	0	0
LIM2	3982	broad.mit.edu	37	19	51885700	51885700	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:51885700G>T	ENST00000221973.3	-	3	465	c.423C>A	c.(421-423)ttC>ttA	p.F141L	LIM2_ENST00000596399.1_Missense_Mutation_p.F99L	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	99					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		TGCCAGCAGAGAAGGGCCGGG	0.567000													11	63					2.27111e-07	2.89092e-07	0.411799	1	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473188	22473188	+	RNA	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:22473188G>T	ENST00000557788.2	-	0	82																											CACCAGTCCTGGGCCCGACTC	0.622000													11	67					4.3838e-07	5.47975e-07	0.435327	1	0
CHEK2P2	646096	broad.mit.edu	37	15	20496752	20496752	+	RNA	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:20496752T>C	ENST00000555186.1	+	0	805					NR_038836.1																						TTTCTTTGAGTCTGTTTTTTA	0.378000													3	17					0	0	0.115264	0	0
TECTA	7007	broad.mit.edu	37	11	120983866	120983866	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:120983866G>T	ENST00000392793.1	+	5	843	c.572G>T	c.(571-573)gGg>gTg	p.G191V	TECTA_ENST00000264037.2_Missense_Mutation_p.G191V			O75443	TECTA_HUMAN	tectorin alpha	191	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TGGACCACGGGGACGGCGAGT	0.572000											OREG0021430	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	49					1.58986e-06	1.92945e-06	0.361761	1	0
GPR141	353345	broad.mit.edu	37	7	37780670	37780670	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:37780670G>A	ENST00000447769.1	+	4	964	c.675G>A	c.(673-675)ctG>ctA	p.L225L	GPR141_ENST00000461610.1_Intron|EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000334425.1_Silent_p.L225L			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	225						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GGGCTCAGCTGAAAAACCTAT	0.428000													61	78					0	0	0.870114	0	0
OLFM1	10439	broad.mit.edu	37	9	137990334	137990334	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:137990334C>G	ENST00000252854.4	+	4	792	c.605C>G	c.(604-606)gCa>gGa	p.A202G	OLFM1_ENST00000371793.3_Missense_Mutation_p.A220G|OLFM1_ENST00000371796.3_Missense_Mutation_p.A193G	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	220					nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		AGGCTCCGTGCATGCATGCAA	0.552000													6	30					0	0	0.217242	0	0
MON1B	22879	broad.mit.edu	37	16	77225496	77225496	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:77225496G>T	ENST00000248248.3	+	2	464	c.114G>T	c.(112-114)ccG>ccT	p.P38P	MON1B_ENST00000320859.6_Silent_p.P38P|MON1B_ENST00000439557.2_Silent_p.P38P|MON1B_ENST00000545553.1_Intron	NM_014940.2	NP_055755.1	Q7L1V2	MON1B_HUMAN	MON1 secretory trafficking family member B	38							protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	17						ACGCGGTCCCGCCGGATCCCG	0.617000													3	20					0.00024832	0.000277143	0.150653	1	0
ERLIN2	11160	broad.mit.edu	37	8	37607944	37607944	+	Missense_Mutation	SNP	G	G	A	rs149254654		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:37607944G>A	ENST00000276461.5	+	9	656	c.589G>A	c.(589-591)Gcc>Acc	p.A197T	ERLIN2_ENST00000519638.1_Missense_Mutation_p.A197T	NM_007175.6	NP_009106.1	O94905	ERLN2_HUMAN	ER lipid raft associated 2	197	Interaction with ERLIN1.				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding			NS(1)|large_intestine(1)|lung(5)	7		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TCTCATTGCCGCCCAGAAACA	0.502000													4	52					0	0	0.150653	0	0
TIAM1	7074	broad.mit.edu	37	21	32638884	32638884	+	Nonsense_Mutation	SNP	G	G	T	rs151048315	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr21:32638884G>T	ENST00000286827.3	-	5	876	c.405C>A	c.(403-405)taC>taA	p.Y135*	TIAM1_ENST00000469412.1_Intron|TIAM1_ENST00000541036.1_Nonsense_Mutation_p.Y135*	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	135					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CGTCATCCCCGTAAAGCCTGC	0.537000													15	47					4.14922e-12	6.11618e-12	0.500413	1	0
TULP4	56995	broad.mit.edu	37	6	158924189	158924189	+	Missense_Mutation	SNP	G	G	C	rs144691972		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:158924189G>C	ENST00000367097.3	+	13	4851	c.3494G>C	c.(3493-3495)cGa>cCa	p.R1165P	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	1165					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GACGTGTCCCGACTGCCCTTC	0.562000													23	88					0	0	0.667858	0	0
PLCB4	5332	broad.mit.edu	37	20	9288539	9288539	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:9288539C>G	ENST00000378501.2	+	1	93	c.78C>G	c.(76-78)taC>taG	p.Y26*	PLCB4_ENST00000414679.2_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000334005.3_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000378493.1_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000378473.3_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000278655.4_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000492632.1_3'UTR	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	26					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TTGACAGATACGAGGAGGTAA	0.294000													15	11					0	0	0.500413	0	0
ZNF512B	57473	broad.mit.edu	37	20	62595516	62595516	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:62595516C>A	ENST00000450537.1	-	8	1448	c.1388G>T	c.(1387-1389)gGg>gTg	p.G463V	ZNF512B_ENST00000369888.1_Missense_Mutation_p.G463V|ZNF512B_ENST00000217130.3_Missense_Mutation_p.G463V			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					AGGGCCTGGCCCCTCCTGCTT	0.662000													47	78					4.64027e-19	7.85953e-19	0.870114	1	0
OR8H1	219469	broad.mit.edu	37	11	56057903	56057903	+	Silent	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:56057903T>G	ENST00000313022.2	-	1	663	c.636A>C	c.(634-636)acA>acC	p.T212T		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					ATGCAGATATTGTGATAAGGG	0.423000													11	100					0	0	0.387290	0	0
BABAM1	29086	broad.mit.edu	37	19	17384795	17384795	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:17384795G>A	ENST00000359435.4	+	4	620	c.427G>A	c.(427-429)Gag>Aag	p.E143K	BABAM1_ENST00000598188.1_Missense_Mutation_p.E143K|BABAM1_ENST00000601043.1_Missense_Mutation_p.E143K|BABAM1_ENST00000448635.2_3'UTR|BABAM1_ENST00000447614.2_Missense_Mutation_p.E143K|BABAM1_ENST00000595632.1_Intron|CTD-2278I10.6_ENST00000596542.1_Missense_Mutation_p.E65K	NM_001033549.1	NP_001028721.1	Q9NWV8	BABA1_HUMAN	BRISC and BRCA1 A complex member 1	143	VWFA-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|protein K63-linked deubiquitination|response to ionizing radiation	BRCA1-A complex|BRISC complex|cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5						CAAAAGCCACGAGTTTGCACT	0.602000													5	33					0	0	0.184627	0	0
C2orf61	285051	broad.mit.edu	37	2	47357382	47357382	+	Silent	SNP	C	C	T	rs139021832		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:47357382C>T	ENST00000294947.2	-	4	452	c.417G>A	c.(415-417)ccG>ccA	p.P139P	C2orf61_ENST00000445927.2_Silent_p.P139P|CALM2_ENST00000422269.1_5'UTR	NM_173649.2	NP_775920.1	Q8N801	CB061_HUMAN	chromosome 2 open reading frame 61	139										endometrium(1)|kidney(1)|lung(2)	4		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGTATTGCCCCGGAGAAAGCT	0.393000													9	77					0	0	0.361761	0	0
BAI1	575	broad.mit.edu	37	8	143559546	143559546	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:143559546G>T	ENST00000517894.1	+	7	2281		c.e7-1		BAI1_ENST00000323289.5_Splice_Site			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1						axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TTCCTCCCCCGGGCCGGGCAG	0.657000													7	4					5.18039e-06	6.19072e-06	0.278610	1	0
PTPRB	5787	broad.mit.edu	37	12	70949649	70949649	+	Splice_Site	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:70949649C>T	ENST00000334414.6	-	19	5038		c.e19+1		PTPRB_ENST00000451516.2_Splice_Site|PTPRB_ENST00000550857.1_Splice_Site|PTPRB_ENST00000550358.1_Splice_Site|PTPRB_ENST00000538708.1_Splice_Site|PTPRB_ENST00000261266.5_Splice_Site	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B						angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGGACACTTACGGTCTATCAT	0.522000													3	27					0	0	0.150653	0	0
WTIP	126374	broad.mit.edu	37	19	34983973	34983973	+	Silent	SNP	C	C	T	rs61729861		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:34983973C>T	ENST00000590071.2	+	3	1138	c.801C>T	c.(799-801)aaC>aaT	p.N267N	WTIP_ENST00000270288.6_Silent_p.N491N	NM_001080436.1	NP_001073905.1			Wilms tumor 1 interacting protein											NS(1)|large_intestine(2)|lung(1)	4	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CGTTCTACAACGTGGGTGAGA	0.627000													4	99					0	0	0.184627	0	0
DCLK1	9201	broad.mit.edu	37	13	36428696	36428696	+	Silent	SNP	C	C	A	rs151019237	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:36428696C>A	ENST00000255448.4	-	6	1186	c.975G>T	c.(973-975)ccG>ccT	p.P325P	DCLK1_ENST00000379892.4_Silent_p.P325P|DCLK1_ENST00000379893.1_Silent_p.P18P|DCLK1_ENST00000460982.1_5'UTR|DCLK1_ENST00000360631.3_Silent_p.P325P	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	325	Pro/Ser-rich.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TGCCTGAGCGCGGAGTAGAGA	0.473000													21	23					3.08376e-08	4.04906e-08	0.654019	1	0
CDH12	1010	broad.mit.edu	37	5	21752263	21752263	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:21752263G>T	ENST00000382254.1	-	15	3054	c.1968C>A	c.(1966-1968)aaC>aaA	p.N656K	CDH12_ENST00000504376.2_Missense_Mutation_p.N656K|CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000522262.1_Missense_Mutation_p.N616K|RP11-804N13.1_ENST00000522350.1_RNA	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	656					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AATGGATGACGTTGTCTCTGA	0.448000										HNSCC(59;0.17)			37	49					2.20474e-14	3.42776e-14	0.788014	1	0
C2orf48	348738	broad.mit.edu	37	2	10350513	10350513	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:10350513G>T	ENST00000381786.3	+	4	559	c.270G>T	c.(268-270)ccG>ccT	p.P90P		NM_182626.2	NP_872432.1	Q96LS8	CB048_HUMAN	chromosome 2 open reading frame 48	90			P -> L (in dbSNP:rs13406078).							endometrium(1)|lung(7)	8	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		GAGAGCCACCGTGGTGCTCAC	0.532000													36	43					3.6622e-26	6.55838e-26	0.788014	1	0
CACNA1A	773	broad.mit.edu	37	19	13397780	13397780	+	Splice_Site	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:13397780T>C	ENST00000360228.5	-	20	3089	c.3089_splice	c.e20-1	p.K1030_splice	CACNA1A_ENST00000573710.2_Splice_Site_p.K1031_splice	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1031					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCTGGTTCTCTCTGAGGAAGG	0.537000													15	7					0	0	0.520397	0	0
IL27RA	9466	broad.mit.edu	37	19	14162997	14162997	+	Silent	SNP	C	C	T	rs151126617	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:14162997C>T	ENST00000263379.2	+	14	1931	c.1806C>T	c.(1804-1806)ccC>ccT	p.P602P		NM_004843.3	NP_004834.1	Q6UWB1	I27RA_HUMAN	interleukin 27 receptor, alpha	602					cell surface receptor linked signaling pathway|immune response	integral to plasma membrane	transmembrane receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	26						CCTCCCAGCCCGCCCAGGCCA	0.662000													12	3					0	0	0.557998	0	0
BCAM	4059	broad.mit.edu	37	19	45322965	45322965	+	Missense_Mutation	SNP	G	G	A	rs147138000		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:45322965G>A	ENST00000391955.1	+	13	1789	c.1745G>A	c.(1744-1746)cGg>cAg	p.R582Q	BCAM_ENST00000270233.6_Missense_Mutation_p.R582Q			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	582					cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				TGCCGCCAGCGGCGGGAGAAG	0.637000													4	15					0	0	0.217242	0	0
PCM1	5108	broad.mit.edu	37	8	17823551	17823551	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:17823551C>A	ENST00000325083.8	+	19	3338	c.2899C>A	c.(2899-2901)Cct>Act	p.P967T	PCM1_ENST00000519253.1_Missense_Mutation_p.P967T|PCM1_ENST00000524226.1_Missense_Mutation_p.P968T	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	967					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		AAATTATCGTCCTTTAGCCAA	0.378000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								9	24					0.00010058	0.000114088	0.411799	1	0
ZNF407	55628	broad.mit.edu	37	18	72344061	72344061	+	Silent	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:72344061T>G	ENST00000299687.5	+	1	1086	c.1086T>G	c.(1084-1086)gtT>gtG	p.V362V	ZNF407_ENST00000582337.1_Silent_p.V362V|ZNF407_ENST00000309902.6_Silent_p.V362V|ZNF407_ENST00000577538.1_Silent_p.V362V	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TAGAGATTGTTGAAGAACATG	0.398000													9	30					0	0	0.307466	0	0
SDK2	54549	broad.mit.edu	37	17	71398169	71398169	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:71398169C>A	ENST00000392650.3	-	19	2596	c.2596G>T	c.(2596-2598)Gag>Tag	p.E866*	SDK2_ENST00000388726.3_Nonsense_Mutation_p.E866*	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	866	Fibronectin type-III 3.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GTGAAGTACTCGGTGAACTTC	0.627000													5	22					1.23904e-05	1.45291e-05	0.184627	1	0
IRX5	10265	broad.mit.edu	37	16	54967504	54967504	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:54967504C>G	ENST00000394636.4	+	3	1508	c.1171C>G	c.(1171-1173)Cct>Gct	p.P391A	IRX5_ENST00000560154.1_Missense_Mutation_p.P171A|IRX5_ENST00000558597.1_Missense_Mutation_p.P325A|IRX5_ENST00000320990.5_Missense_Mutation_p.P390A			P78411	IRX5_HUMAN	iroquois homeobox 5	391					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						GGCGCAGTGTCCTTTTCCAGG	0.692000													4	21					0	0	0.184627	0	0
TBX3	6926	broad.mit.edu	37	12	115118696	115118696	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:115118696G>A	ENST00000349155.2	-	2	1608	c.645C>T	c.(643-645)gaC>gaT	p.D215D	TBX3_ENST00000257566.3_Silent_p.D215D	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	215					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		ATCCATGTTTGTCTGAAATGT	0.448000													9	114					0	0	0.307466	0	0
GABBR1	2550	broad.mit.edu	37	6	29571327	29571327	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:29571327T>C	ENST00000377034.4	-	23	3214	c.2879A>G	c.(2878-2880)tAt>tGt	p.Y960C	GABBR1_ENST00000377016.4_Missense_Mutation_p.Y898C|GABBR1_ENST00000377012.4_Missense_Mutation_p.Y843C|GABBR1_ENST00000376977.3_3'UTR|GABBR1_ENST00000355973.3_Missense_Mutation_p.Y843C	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	960					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	ccctcACTTATAAAGCAAATG	0.657000													3	7					0	0	0.115264	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187702207	187702207	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:187702207G>T	ENST00000295131.2	-	5	608	c.569C>A	c.(568-570)tCc>tAc	p.S190Y		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	190					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TTTCAACATGGAAGTGTTTGA	0.348000													12	51					6.42651e-13	9.63206e-13	0.387290	1	0
THSD7B	80731	broad.mit.edu	37	2	137852671	137852671	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:137852671A>C	ENST00000409968.1	+	4	1357	c.1179A>C	c.(1177-1179)gaA>gaC	p.E393D	THSD7B_ENST00000543459.1_Missense_Mutation_p.E252D|THSD7B_ENST00000272643.3_Missense_Mutation_p.E393D|THSD7B_ENST00000413152.2_Missense_Mutation_p.E362D					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTGAAGGAGAACTTCTGCAGC	0.443000													5	28					0	0	0.217242	0	0
MAP2K7	5609	broad.mit.edu	37	19	7977303	7977303	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:7977303C>T	ENST00000545011.1	+	11	1438	c.1373C>T	c.(1372-1374)cCc>cTc	p.P458L	MAP2K7_ENST00000397983.3_Missense_Mutation_p.P432L|MAP2K7_ENST00000397979.3_Missense_Mutation_p.P416L|MAP2K7_ENST00000397981.3_Missense_Mutation_p.P423L			O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	416					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(3)|endometrium(1)|large_intestine(8)|lung(4)|ovary(1)	19					Etoposide(DB00773)	CCCCACCTGCCCTTCTTCAGG	0.687000													11	11					0	0	0.387290	0	0
POTEE	445582	broad.mit.edu	37	2	132021821	132021821	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:132021821C>A	ENST00000356920.5	+	15	2887	c.2793C>A	c.(2791-2793)gcC>gcA	p.A931A	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	931	Actin-like.						ATP binding										CCACGGCGGCCTCCAGCTCCT	0.612000													44	257					7.05121e-23	1.23101e-22	0.853193	1	0
GRM3	2913	broad.mit.edu	37	7	86415678	86415678	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:86415678C>A	ENST00000361669.2	+	3	1669	c.570C>A	c.(568-570)acC>acA	p.T190T	GRM3_ENST00000536043.1_Silent_p.T62T|GRM3_ENST00000394720.2_Silent_p.T188T|AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000439827.1_Silent_p.T190T|AC005009.2_ENST00000418031.1_RNA	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	190					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TTGCCAGGACCGTGCCCCCCG	0.567000													9	104					0.0477658	0.0496732	0.307466	1	0
ZZEF1	23140	broad.mit.edu	37	17	3969745	3969745	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:3969745G>C	ENST00000381638.2	-	28	4369	c.4245C>G	c.(4243-4245)agC>agG	p.S1415R		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1415							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						ACTCACCCAGGCTCTCAGGGT	0.453000													12	105					0	0	0.479597	0	0
WWC2	80014	broad.mit.edu	37	4	184210685	184210685	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:184210685G>A	ENST00000403733.3	+	21	3480	c.3281G>A	c.(3280-3282)cGg>cAg	p.R1094Q	WWC2_ENST00000504005.1_Missense_Mutation_p.R776Q|WWC2_ENST00000508747.1_Missense_Mutation_p.R222Q|WWC2_ENST00000513834.1_Missense_Mutation_p.R1045Q|WWC2_ENST00000448232.2_Missense_Mutation_p.R1118Q	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1094										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		AGGGACTTGCGGCAGAAGCTG	0.577000													3	21					0	0	0.115264	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416406	105416406	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:105416406C>G	ENST00000333244.5	-	7	5501	c.5382G>C	c.(5380-5382)gaG>gaC	p.E1794D	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1794						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTCCTGGAGCCTCGACGTCCA	0.627000													88	140					0	0	0.870114	0	0
NT5C1A	84618	broad.mit.edu	37	1	40131283	40131283	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:40131283G>T	ENST00000235628.1	-	3	342	c.343C>A	c.(343-345)Cct>Act	p.P115T		NM_032526.1	NP_115915.1	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	115					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			breast(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)	15	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TCACTATCAGGGTACAGCTCC	0.557000													7	22					2.0095e-06	2.43398e-06	0.248553	1	0
TPO	7173	broad.mit.edu	37	2	1488432	1488432	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:1488432G>A	ENST00000345913.4	+	9	1494	c.1403G>A	c.(1402-1404)gGt>gAt	p.G468D	TPO_ENST00000382198.1_Missense_Mutation_p.G295D|TPO_ENST00000382201.3_Missense_Mutation_p.G468D|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000349624.3_Missense_Mutation_p.G295D|TPO_ENST00000337415.3_Missense_Mutation_p.G468D|TPO_ENST00000329066.4_Missense_Mutation_p.G468D|TPO_ENST00000346956.3_Missense_Mutation_p.G468D	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	468					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CAGTACGTGGGTCCCTATGAA	0.597000													19	39					0	0	0.539581	0	0
OR2G3	81469	broad.mit.edu	37	1	247769130	247769130	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:247769130C>T	ENST00000320002.2	+	1	275	c.243C>T	c.(241-243)acC>acT	p.T81T	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTCCTCAGACCTTAGTTAACT	0.458000													33	336					0	0	0.750413	0	0
KCNA5	3741	broad.mit.edu	37	12	5154822	5154822	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:5154822C>A	ENST00000252321.3	+	1	1738	c.1509C>A	c.(1507-1509)gcC>gcA	p.A503A		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	503						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						GTGCCATCGCCGGGGTCCTCA	0.612000													39	53					5.78141e-17	9.45912e-17	0.864702	1	0
THSD7B	80731	broad.mit.edu	37	2	138000066	138000066	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:138000066T>A	ENST00000409968.1	+	10	2368	c.2190T>A	c.(2188-2190)tgT>tgA	p.C730*	THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000272643.3_Nonsense_Mutation_p.C730*|THSD7B_ENST00000413152.2_Nonsense_Mutation_p.C699*					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGCGCCCCTGTTTTCTCCCAT	0.478000													22	31					0	0	0.681144	0	0
TUBA3D	113457	broad.mit.edu	37	2	132236926	132236926	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:132236926A>G	ENST00000321253.6	+	3	379	c.272A>G	c.(271-273)cAg>cGg	p.Q91R	TUBA3D_ENST00000409047.2_3'UTR	NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	91					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		CACCCGGAGCAGCTGATCACC	0.527000													57	94					0	0	0.870114	0	0
SNX9	51429	broad.mit.edu	37	6	158288666	158288666	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:158288666G>T	ENST00000392185.3	+	2	270		c.e2+1			NM_016224.3	NP_057308.1	Q9Y5X1	SNX9_HUMAN	sorting nexin 9						cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		CACAAATCCGGTAAGAGAACT	0.413000													16	34					1.52009e-12	2.26744e-12	0.479597	1	0
SLC22A25	387601	broad.mit.edu	37	11	62931422	62931422	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:62931422G>C	ENST00000306494.6	-	9	1517	c.1518C>G	c.(1516-1518)atC>atG	p.I506M	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000525620.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	506					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						GGCCAGAGAGGATGGCAAAGA	0.498000													11	96					0	0	0.411799	0	0
TUBB8P7	197331	broad.mit.edu	37	16	90162236	90162236	+	RNA	SNP	G	G	T	rs4462586		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:90162236G>T	ENST00000567960.1	+	0	972				TUBB8P7_ENST00000564451.1_RNA																							ATGCCCATGAGGGAGGTGGAT	0.517000													10	100					2.27111e-07	2.89092e-07	0.411799	1	0
RASGRP3	25780	broad.mit.edu	37	2	33747032	33747032	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:33747032G>A	ENST00000403687.3	+	7	1119	c.379G>A	c.(379-381)Gac>Aac	p.D127N	RASGRP3_ENST00000402538.3_Missense_Mutation_p.D127N|RASGRP3_ENST00000407811.1_Missense_Mutation_p.D127N	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	127					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					TCCTTCCTATGACTGGATGAG	0.443000													29	99					0	0	0.740014	0	0
PNLIP	5406	broad.mit.edu	37	10	118314998	118314998	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:118314998G>T	ENST00000369221.2	+	8	818	c.790G>T	c.(790-792)Gac>Tac	p.D264Y		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	264					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TCAGATTGTGGACATAGACGG	0.408000													43	126					2.43468e-25	4.3107e-25	0.870114	1	0
OR4D11	219986	broad.mit.edu	37	11	59271269	59271269	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:59271269C>A	ENST00000313253.1	+	1	221	c.221C>A	c.(220-222)tCc>tAc	p.S74Y		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						ATCTGCTTCTCCTCCACAACT	0.488000													93	107					4.21487e-37	7.84016e-37	0.870114	1	0
OR4D5	219875	broad.mit.edu	37	11	123810885	123810885	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:123810885G>T	ENST00000307033.2	+	1	636	c.562G>T	c.(562-564)Gcc>Tcc	p.A188S		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GATCAAATTGGCCTGCACAGA	0.468000													10	93					1.58986e-06	1.92945e-06	0.361761	1	0
ATP8A2	51761	broad.mit.edu	37	13	26163785	26163785	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:26163785G>T	ENST00000381655.2	+	24	2301	c.2159G>T	c.(2158-2160)cGa>cTa	p.R720L	ATP8A2_ENST00000491840.1_3'UTR|ATP8A2_ENST00000255283.8_Missense_Mutation_p.R680L	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	680					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TATTCCTGCCGATTGGTATCG	0.388000													22	42					3.08376e-08	4.04906e-08	0.654019	1	0
NLRP4	147945	broad.mit.edu	37	19	56369987	56369987	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:56369987G>A	ENST00000301295.6	+	3	1650	c.1228G>A	c.(1228-1230)Gac>Aac	p.D410N	NLRP4_ENST00000346986.5_Missense_Mutation_p.D410N|NLRP4_ENST00000587891.1_Missense_Mutation_p.D335N	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	410	NACHT.						ATP binding	p.D410N(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TATGTGGACAGACACATTTGA	0.572000													15	70					0	0	0.479597	0	0
SLC24A4	123041	broad.mit.edu	37	14	92958097	92958097	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:92958097C>T	ENST00000532405.1	+	15	1852	c.1626C>T	c.(1624-1626)acC>acT	p.T542T	SLC24A4_ENST00000393265.2_Silent_p.T478T|SLC24A4_ENST00000351924.5_Silent_p.T506T|SLC24A4_ENST00000531433.1_Silent_p.T523T|SLC24A4_ENST00000298877.1_Silent_p.T525T			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	542						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		GCCTGCAGACCATGGTTGTTA	0.517000													15	32					0	0	0.479597	0	0
KIF2B	84643	broad.mit.edu	37	17	51901335	51901335	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:51901335G>T	ENST00000268919.4	+	1	1097	c.941G>T	c.(940-942)gGt>gTt	p.G314V		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	314	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TACACCATGGGTGGAGACTTT	0.542000													20	64					1.00905e-13	1.53071e-13	0.575678	1	0
SPERT	220082	broad.mit.edu	37	13	46287784	46287784	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:46287784C>A	ENST00000378966.3	+	2	932	c.516C>A	c.(514-516)ggC>ggA	p.G172G	SPERT_ENST00000310521.1_Silent_p.G208G			Q8NA61	SPERT_HUMAN	spermatid associated	208						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CCTCGCTGGGCCGAGAGGAGA	0.652000													9	22					7.48243e-07	9.26043e-07	0.335167	1	0
CSMD3	114788	broad.mit.edu	37	8	113349026	113349026	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:113349026C>A	ENST00000297405.5	-	44	7118	c.6874G>T	c.(6874-6876)Ggc>Tgc	p.G2292C	CSMD3_ENST00000352409.3_Missense_Mutation_p.G2222C|CSMD3_ENST00000455883.2_Missense_Mutation_p.G2188C|CSMD3_ENST00000343508.3_Missense_Mutation_p.G2252C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2292	CUB 13.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TAAATGGTGCCATTCATTGCA	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	115					0.000274275	0.000305021	0.307466	1	0
DEDD2	162989	broad.mit.edu	37	19	42713941	42713941	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:42713941C>T	ENST00000595337.1	-	4	587	c.500G>A	c.(499-501)gGt>gAt	p.G167D	DEDD2_ENST00000598727.1_Missense_Mutation_p.G167D|DEDD2_ENST00000336034.4_Missense_Mutation_p.G162D|DEDD2_ENST00000596251.1_Missense_Mutation_p.G167D|DEDD2_ENST00000593804.1_5'UTR	NM_001270614.1	NP_001257543.1	Q8WXF8	DEDD2_HUMAN	death effector domain containing 2	167					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(2)	5		Prostate(69;0.0704)				CCGTCTGGCACCACCACTGGG	0.662000													33	23					0	0	0.769981	0	0
TCERG1L	256536	broad.mit.edu	37	10	132915186	132915186	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:132915186C>A	ENST00000368642.4	-	9	1356	c.1271G>T	c.(1270-1272)tGc>tTc	p.C424F		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	424										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		GGGACTCCCGCAGCCTTCGGT	0.572000													7	10					0.00448238	0.00481355	0.307466	1	0
KRTAP23-1	337963	broad.mit.edu	37	21	31720769	31720769	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr21:31720769G>T	ENST00000334160.4	-	1	155	c.156C>A	c.(154-156)ctC>ctA	p.L52L		NM_181624.1	NP_853655.1	A1A580	KR231_HUMAN	keratin associated protein 23-1	52						intermediate filament				large_intestine(1)|lung(4)|prostate(1)	6						CTTGCAGAGAGAGGAACCCAG	0.602000													11	29					2.80697e-09	3.78911e-09	0.387290	1	0
COL9A1	1297	broad.mit.edu	37	6	71009778	71009778	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:71009778C>T	ENST00000357250.6	-	4	425	c.267G>A	c.(265-267)ttG>ttA	p.L89L	COL9A1_ENST00000370496.3_Silent_p.L89L	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	89	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CATTATTTCCCAACTTGTAAG	0.368000													4	84					0	0	0.184627	0	0
HECTD3	79654	broad.mit.edu	37	1	45474216	45474216	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:45474216G>T	ENST00000372172.4	-	8	1301	c.1230C>A	c.(1228-1230)ctC>ctA	p.L410L	HECTD3_ENST00000372168.3_5'UTR	NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	410					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					ACCTCTGCAGGAGGACAGCTC	0.557000													27	78					2.44723e-14	3.79533e-14	0.681144	1	0
DMP1	1758	broad.mit.edu	37	4	88584435	88584435	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:88584435G>T	ENST00000339673.6	+	6	1604	c.1505G>T	c.(1504-1506)gGg>gTg	p.G502V	DMP1_ENST00000282479.7_Missense_Mutation_p.G486V|RP11-742B18.1_ENST00000506480.1_RNA|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	502					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		AAACCCATTGGGGACCAAGAT	0.433000													38	38					1.43246e-33	2.62548e-33	0.834066	1	0
ZNF532	55205	broad.mit.edu	37	18	56586785	56586785	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:56586785G>T	ENST00000336078.4	+	4	2042	c.1266G>T	c.(1264-1266)gcG>gcT	p.A422A	ZNF532_ENST00000591808.1_Silent_p.A422A|ZNF532_ENST00000591230.1_Silent_p.A422A|ZNF532_ENST00000591083.1_Silent_p.A422A|ZNF532_ENST00000589288.1_Silent_p.A422A	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						CCCCCAGGGCGCCTCTCCAGT	0.592000													13	10					2.27111e-07	2.89092e-07	0.411799	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176173	140176173	+	Missense_Mutation	SNP	G	G	T	rs149176013		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:140176173G>T	ENST00000526136.1	+	1	1624	c.1624G>T	c.(1624-1626)Gtg>Ttg	p.V542L	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.V542L|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.V542L	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATGCGGGCGTGCCGCCTCT	0.687000													27	56					7.01153e-11	9.84766e-11	0.717897	1	0
OR5M9	390162	broad.mit.edu	37	11	56230648	56230648	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:56230648G>C	ENST00000279791.1	-	1	229	c.230C>G	c.(229-231)cCc>cGc	p.P77R		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					CAGCATTTTGGGGGTAACGTT	0.448000													9	51					0	0	0.307466	0	0
UNC5B	219699	broad.mit.edu	37	10	73047497	73047497	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:73047497G>T	ENST00000335350.6	+	6	1292	c.876G>T	c.(874-876)aaG>aaT	p.K292N	UNC5B_ENST00000373192.4_Missense_Mutation_p.K292N	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	292	TSP type-1 1.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CATTCCAGAAGACCGCCTGCA	0.657000													4	36					1.23904e-05	1.45291e-05	0.184627	1	0
TNXB	7148	broad.mit.edu	37	6	32023635	32023635	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:32023635A>G	ENST00000375244.3	-	24	8661	c.8460T>C	c.(8458-8460)ggT>ggC	p.G2820G	TNXB_ENST00000375247.2_Silent_p.G2820G			P22105	TENX_HUMAN	tenascin XB	2878	Fibronectin type-III 20.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding	p.G2820G(1)|p.G2907G(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CACCTGTCACACCCACGGTGG	0.582000													4	57					0	0	0.184627	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121699934	121699934	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:121699934G>C	ENST00000393386.2	+	29	7210	c.6799G>C	c.(6799-6801)Gct>Cct	p.A2267P	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.A1400P	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2267	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AGGAGTCTTTGCTGACATTGT	0.403000													32	29					0	0	0.769981	0	0
FLG	2312	broad.mit.edu	37	1	152276103	152276103	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:152276103C>A	ENST00000368799.1	-	3	11294	c.11259G>T	c.(11257-11259)gaG>gaT	p.E3753D	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3753	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity	p.E3753D(1)		autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTCCTGACCCTCTTGGGACG	0.617000									Ichthyosis				89	319					2.78421e-50	5.2572e-50	0.870114	1	0
GPR112	139378	broad.mit.edu	37	X	135496331	135496331	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:135496331G>T	ENST00000394143.1	+	25	9341	c.9050G>T	c.(9049-9051)cGg>cTg	p.R3017L	GPR112_ENST00000412101.1_Missense_Mutation_p.R2812L|GPR112_ENST00000394141.1_Missense_Mutation_p.R2812L|GPR112_ENST00000370652.1_Missense_Mutation_p.R3017L|GPR112_ENST00000287534.4_Missense_Mutation_p.R2736L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	3017					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GGGAGCAGCCGGTGTCAGATA	0.353000													11	76					7.03913e-09	9.42067e-09	0.411799	1	0
FAM47C	442444	broad.mit.edu	37	X	37028267	37028267	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:37028267C>T	ENST00000358047.3	+	1	1836	c.1784C>T	c.(1783-1785)cCc>cTc	p.P595L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	595										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCCAGTCTCCCCCCGGAGCCC	0.647000													32	42					0	0	0.864702	0	0
FRMPD2	143162	broad.mit.edu	37	10	49440192	49440192	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:49440192C>T	ENST00000374201.3	-	10	1436	c.1134G>A	c.(1132-1134)gaG>gaA	p.E378E	FRMPD2_ENST00000305531.3_Silent_p.E354E|FRMPD2_ENST00000407470.4_Silent_p.E347E	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	378	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		AGGTGAGTTCCTCGAGGTTGG	0.522000													13	80					0	0	0.500413	0	0
FBXO24	26261	broad.mit.edu	37	7	100189329	100189329	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:100189329G>A	ENST00000241071.6	+	4	684	c.362G>A	c.(361-363)cGc>cAc	p.R121H	FBXO24_ENST00000360609.2_Missense_Mutation_p.R107H|FBXO24_ENST00000498195.1_3'UTR|FBXO24_ENST00000468962.1_Missense_Mutation_p.R109H|FBXO24_ENST00000465843.1_Missense_Mutation_p.R107H|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000427939.2_Missense_Mutation_p.R159H	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	121						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GGAGGCCGCCGCCGATGTCTC	0.582000													14	51					0	0	0.457914	0	0
PNLIP	5406	broad.mit.edu	37	10	118314997	118314997	+	Silent	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:118314997G>C	ENST00000369221.2	+	8	817	c.789G>C	c.(787-789)gtG>gtC	p.V263V		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	263					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CTCAGATTGTGGACATAGACG	0.408000													42	128					0	0	0.870114	0	0
CLCA4	22802	broad.mit.edu	37	1	87025657	87025657	+	Missense_Mutation	SNP	G	G	C	rs148031684		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:87025657G>C	ENST00000370563.3	+	2	244	c.202G>C	c.(202-204)Gaa>Caa	p.E68Q	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	68						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TGAAGCCACAGAAAAAAGATT	0.328000													9	83					0	0	0.307466	0	0
ZNF700	90592	broad.mit.edu	37	19	12060148	12060148	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:12060148G>A	ENST00000482090.1	+	3	1673	c.1255G>A	c.(1255-1257)Ggt>Agt	p.G419S	ZNF763_ENST00000590798.1_Intron|ZNF763_ENST00000591944.1_Intron|ZNF700_ENST00000254321.5_Missense_Mutation_p.G437S|ZNF763_ENST00000538752.1_Intron|CTD-2006C1.12_ENST00000586394.1_RNA			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						TCGAGTGCACGGTGGGACTCA	0.483000													14	56					0	0	0.457914	0	0
MOXD1	26002	broad.mit.edu	37	6	132636912	132636912	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:132636912C>A	ENST00000367963.3	-	10	1488	c.1370G>T	c.(1369-1371)gGa>gTa	p.G457V	MOXD1_ENST00000489128.1_5'UTR|MOXD1_ENST00000336749.3_Missense_Mutation_p.G389V	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	457					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		GGTGCTTAGTCCTCCCTGAAA	0.353000													19	76					2.94398e-08	3.88183e-08	0.557998	1	0
ATP12A	479	broad.mit.edu	37	13	25283930	25283930	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:25283930C>A	ENST00000218548.6	+	19	3078	c.2745C>A	c.(2743-2745)taC>taA	p.Y915*	ATP12A_ENST00000381946.3_Nonsense_Mutation_p.Y909*	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	909					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AGAAGGACTACGTGAATGACT	0.547000													30	40					1.30897e-18	2.20514e-18	0.740014	1	0
CSMD3	114788	broad.mit.edu	37	8	113349025	113349025	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:113349025C>A	ENST00000297405.5	-	44	7119	c.6875G>T	c.(6874-6876)gGc>gTc	p.G2292V	CSMD3_ENST00000352409.3_Missense_Mutation_p.G2222V|CSMD3_ENST00000455883.2_Missense_Mutation_p.G2188V|CSMD3_ENST00000343508.3_Missense_Mutation_p.G2252V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2292	CUB 13.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATAAATGGTGCCATTCATTGC	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	117					0.000274275	0.000305021	0.307466	1	0
BPIFB1	92747	broad.mit.edu	37	20	31878785	31878785	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:31878785G>C	ENST00000253354.1	+	5	549	c.388G>C	c.(388-390)Gag>Cag	p.E130Q		NM_033197.2	NP_149974.2	Q8TDL5	LPLC1_HUMAN	BPI fold containing family B, member 1	130						extracellular space	lipid binding										GACCATCGTGGAGTTCCACAT	0.637000													6	14					0	0	0.217242	0	0
KEL	3792	broad.mit.edu	37	7	142651304	142651304	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:142651304C>A	ENST00000355265.2	-	8	1365	c.891G>T	c.(889-891)aaG>aaT	p.K297N	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	297					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCTGGAAGAGCTTGCCCTGTG	0.557000													13	14					1.3612e-06	1.66163e-06	0.479597	1	0
PRRC2C	23215	broad.mit.edu	37	1	171509669	171509669	+	Missense_Mutation	SNP	G	G	T	rs142556260		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:171509669G>T	ENST00000367742.3	+	16	3306	c.3064G>T	c.(3064-3066)Gta>Tta	p.V1022L	PRRC2C_ENST00000392078.3_Missense_Mutation_p.V1022L|PRRC2C_ENST00000338920.4_Missense_Mutation_p.V1020L|PRRC2C_ENST00000426496.2_Missense_Mutation_p.V1020L			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1020							protein C-terminus binding										TAAAAAACCTGTACTTAGAGA	0.423000													3	24					0.004672	0.00496599	0.115264	1	0
ERAP2	64167	broad.mit.edu	37	5	96224887	96224887	+	Splice_Site	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:96224887A>T	ENST00000437043.3	+	5	1560		c.e5-1		ERAP2_ENST00000510309.1_Splice_Site|CTD-2260A17.2_ENST00000501338.1_Intron|ERAP2_ENST00000379904.4_Splice_Site	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2						antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		CACATTTCCCAGGTGTCCATC	0.408000													14	27					0	0	0.435327	0	0
MYO16	23026	broad.mit.edu	37	13	109672245	109672245	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:109672245C>T	ENST00000356711.2	+	23	2842	c.2716C>T	c.(2716-2718)Cac>Tac	p.H906Y	MYO16_ENST00000357550.2_Missense_Mutation_p.H906Y|MYO16_ENST00000457511.2_Missense_Mutation_p.H418Y|MYO16_ENST00000251041.5_Missense_Mutation_p.H906Y	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	906	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CACCATCATGCACTACGCAGG	0.453000													3	21					0	0	0.115264	0	0
OR10K2	391107	broad.mit.edu	37	1	158390612	158390612	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:158390612G>A	ENST00000314902.2	-	1	44	c.45C>T	c.(43-45)ctC>ctT	p.L15L		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					ATGAGAAGCCGAGGAAGATGA	0.512000													15	48					0	0	0.520397	0	0
PCSK1	5122	broad.mit.edu	37	5	95728882	95728882	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:95728882G>T	ENST00000311106.3	-	14	2322	c.2085C>A	c.(2083-2085)atC>atA	p.I695I	PCSK1_ENST00000513085.1_5'UTR|PCSK1_ENST00000508626.1_Silent_p.I648I|CTD-2337A12.1_ENST00000502645.2_RNA	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	695					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTCATAAGGGATGTTGAGCT	0.448000													19	71					6.94344e-10	9.51678e-10	0.539581	1	0
MSMB	4477	broad.mit.edu	37	10	51556792	51556792	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:51556792G>C	ENST00000358559.2	+	3	238	c.151G>C	c.(151-153)Gag>Cag	p.E51Q	MSMB_ENST00000298239.6_Intron|MSMB_ENST00000474170.1_3'UTR	NM_002443.3	NP_002434.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	51						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						AATAAACTCGGAGTGGCAGAC	0.443000													20	34					0	0	0.624587	0	0
T	6862	broad.mit.edu	37	6	166575945	166575945	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:166575945G>T	ENST00000296946.2	-	7	1362	c.894C>A	c.(892-894)aaC>aaA	p.N298K	T_ENST00000366871.3_Intron	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	298					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		TTGGAGAATTGTTCCGATGAG	0.577000									Chordoma, Familial Clustering of				15	30					6.31663e-08	8.24195e-08	0.479597	1	0
DCHS2	54798	broad.mit.edu	37	4	155305557	155305557	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:155305557C>A	ENST00000357232.3	-	2	196	c.197G>T	c.(196-198)aGc>aTc	p.S66I	DCHS2_ENST00000339452.1_Intron	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	66	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ctcttcctggcttctgaacac	0.507000													7	11					0.248553	0.252184	0.248553	1	0
VWC2L	402117	broad.mit.edu	37	2	215440444	215440444	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:215440444T>G	ENST00000312504.5	+	4	1371	c.569T>G	c.(568-570)gTg>gGg	p.V190G	VWC2L_ENST00000427124.1_3'UTR|AC107218.3_ENST00000437883.1_RNA|AC107218.3_ENST00000412896.1_RNA	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	190						extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						GGCATTGAAGTGAAAGTGGAC	0.458000													30	97					0	0	0.729181	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458253	45458253	+	RNA	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:45458253G>T	ENST00000548424.1	+	0	448																											ATAGAATTCAGGTTTAATAAC	0.468000													6	5					0.00116845	0.00127226	0.217242	1	0
DMP1	1758	broad.mit.edu	37	4	88584434	88584434	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:88584434G>A	ENST00000339673.6	+	6	1603	c.1504G>A	c.(1504-1506)Ggg>Agg	p.G502R	DMP1_ENST00000282479.7_Missense_Mutation_p.G486R|RP11-742B18.1_ENST00000506480.1_RNA|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	502					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding	p.G502W(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CAAACCCATTGGGGACCAAGA	0.438000													36	39					0	0	0.819951	0	0
FIG4	9896	broad.mit.edu	37	6	110037688	110037688	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:110037688G>T	ENST00000230124.3	+	3	330	c.206G>T	c.(205-207)cGc>cTc	p.R69L	FIG4_ENST00000441478.2_Intron	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	69					cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CTTCTTGGCCGCTTGGATCTT	0.398000													13	40					7.93312e-07	9.77949e-07	0.457914	1	0
ARV1	64801	broad.mit.edu	37	1	231131652	231131652	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:231131652T>C	ENST00000310256.2	+	4	652	c.595T>C	c.(595-597)Tgg>Cgg	p.W199R	ARV1_ENST00000497753.1_3'UTR|ARV1_ENST00000366658.2_Missense_Mutation_p.W159R	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	199					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		AGCTGTCATTTGGGAACATGA	0.373000													26	85					0	0	0.681144	0	0
ACY3	91703	broad.mit.edu	37	11	67410317	67410317	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:67410317G>A	ENST00000255082.3	-	8	1008	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S	ACY3_ENST00000529256.1_Missense_Mutation_p.P159S	NM_080658.1	NP_542389.1	Q96HD9	ACY3_HUMAN	aspartoacylase (aminocyclase) 3	280					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding			endometrium(1)|lung(5)|prostate(2)	8					L-Aspartic Acid(DB00128)	ATGAACACGGGGTACACCGTG	0.587000													13	37					0	0	0.435327	0	0
FCRL2	79368	broad.mit.edu	37	1	157718359	157718359	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:157718359C>G	ENST00000361516.3	-	10	1491	c.1443G>C	c.(1441-1443)caG>caC	p.Q481H	FCRL2_ENST00000368181.4_Intron|FCRL2_ENST00000392274.3_Intron	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	481					cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity	p.Q481Q(1)		central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTTCTGGCTGCTGCATGCTCC	0.453000													12	73					0	0	0.435327	0	0
KRT5	3852	broad.mit.edu	37	12	52911461	52911461	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:52911461C>A	ENST00000252242.4	-	5	1395	c.1005G>T	c.(1003-1005)ctG>ctT	p.L335L		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	335	Linker 12.|Rod.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton	p.L335L(1)		endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGATGCTATCCAGGTCCAGGT	0.572000													28	97					1.77063e-15	2.81589e-15	0.693898	1	0
XKR7	343702	broad.mit.edu	37	20	30584719	30584719	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:30584719G>T	ENST00000217299.3	+	3	1373	c.1199G>T	c.(1198-1200)gGc>gTc	p.G400V		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	400						integral to membrane		p.G400D(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GCGCTCACCGGCTTCTGGTAC	0.582000													14	27					3.27435e-08	4.29029e-08	0.457914	1	0
ARMC4	55130	broad.mit.edu	37	10	28233798	28233798	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:28233798C>A	ENST00000305242.5	-	11	1572	c.1480G>T	c.(1480-1482)Gga>Tga	p.G494*	ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000545014.1_Nonsense_Mutation_p.G19*|ARMC4_ENST00000537576.1_Nonsense_Mutation_p.G186*	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	494							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TCCAGGCCTCCAACATCTCTG	0.468000													22	70					2.27731e-05	2.6604e-05	0.608945	1	0
KRTAP13-4	284827	broad.mit.edu	37	21	31802740	31802740	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr21:31802740G>T	ENST00000334068.2	+	1	169	c.147G>T	c.(145-147)agG>agT	p.R49S		NM_181600.1	NP_853631.1	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	49	4 X 10 AA approximate repeats.					intermediate filament		p.R49R(1)		NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	15						CTCTCTACAGGGACTGTCAGA	0.627000													15	50					1.3612e-06	1.66163e-06	0.479597	1	0
ZNF114	163071	broad.mit.edu	37	19	48789422	48789422	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:48789422G>T	ENST00000595607.1	+	6	1035	c.541G>T	c.(541-543)Ggg>Tgg	p.G181W	ZNF114_ENST00000600687.1_Missense_Mutation_p.G181W|ZNF114_ENST00000315849.1_Missense_Mutation_p.G181W|ZNF114_ENST00000597695.1_Missense_Mutation_p.G147W			Q8NC26	ZN114_HUMAN	zinc finger protein 114	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)	18		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		TGGAGTCTTGGGGTGGAACAT	0.408000													35	38					7.61001e-30	1.38263e-29	0.812448	1	0
CAPS2	84698	broad.mit.edu	37	12	75678818	75678818	+	Missense_Mutation	SNP	C	C	A	rs148668279	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:75678818C>A	ENST00000393284.3	-	15	1400	c.799G>T	c.(799-801)Ggc>Tgc	p.G267C	CAPS2_ENST00000409445.3_Missense_Mutation_p.G499C|CAPS2_ENST00000409004.1_5'UTR|CAPS2_ENST00000442339.2_Missense_Mutation_p.G89C|CAPS2_ENST00000409799.1_Missense_Mutation_p.G417C|RP11-560G2.1_ENST00000549953.1_RNA			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	499							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						TCAACCTTGCCATTGCCATTG	0.328000													5	38					0.000602214	0.000664989	0.184627	1	0
PHLPP1	23239	broad.mit.edu	37	18	60609049	60609049	+	Missense_Mutation	SNP	C	C	G	rs74653132		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:60609049C>G	ENST00000400316.4	+	11	3304	c.1523C>G	c.(1522-1524)aCa>aGa	p.T508R	PHLPP1_ENST00000262719.5_Missense_Mutation_p.T1020R	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1020					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						TTGTATTTGACAAATAACAGC	0.468000													6	25					0	0	0.248553	0	0
OR4A16	81327	broad.mit.edu	37	11	55111085	55111085	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:55111085C>A	ENST00000314721.2	+	1	459	c.409C>A	c.(409-411)Ctg>Atg	p.L137M		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						CATGAATCGACTGGTTTGCAT	0.473000													50	59					5.73435e-26	1.02399e-25	0.870114	1	0
LIN54	132660	broad.mit.edu	37	4	83849377	83849377	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:83849377T>G	ENST00000340417.3	-	13	2505	c.2128A>C	c.(2128-2130)Aag>Cag	p.K710Q	LIN54_ENST00000505397.1_Missense_Mutation_p.K710Q|LIN54_ENST00000446851.2_Missense_Mutation_p.K489Q|LIN54_ENST00000442461.2_Missense_Mutation_p.K489Q|LIN54_ENST00000395283.2_Missense_Mutation_p.K621Q|LIN54_ENST00000510557.1_Missense_Mutation_p.K489Q|LIN54_ENST00000395282.2_3'UTR|LIN54_ENST00000506560.1_Missense_Mutation_p.K621Q	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	710					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				TTTCCCTTCTTGTCTGCCTGC	0.438000													7	35					0	0	0.278610	0	0
CCDC170	80129	broad.mit.edu	37	6	151894619	151894619	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:151894619G>C	ENST00000367290.5	+	6	1174	c.1085G>C	c.(1084-1086)aGg>aCg	p.R362T	CCDC170_ENST00000239374.7_Missense_Mutation_p.R362T			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	362																	GAAGAAAGCAGGGACCGGGTG	0.488000													15	36					0	0	0.520397	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89476584	89476584	+	RNA	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:89476584G>T	ENST00000484817.1	-	0	60																											CAGAGCATTAGCAGCCCCAGA	0.532000													4	24					1.06961e-07	1.38407e-07	0.278610	1	0
BIRC8	112401	broad.mit.edu	37	19	53793612	53793612	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:53793612C>A	ENST00000426466.1	-	1	1263	c.16G>T	c.(16-18)Gcc>Tcc	p.A6S		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	6					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		ATGAGCCGGGCTTCATAACCC	0.418000													26	21					6.32553e-13	9.5035e-13	0.681144	1	0
ZNF500	26048	broad.mit.edu	37	16	4812313	4812313	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:4812313C>A	ENST00000219478.6	-	4	921	c.622G>T	c.(622-624)Gag>Tag	p.E208*	ZNF500_ENST00000545009.1_Nonsense_Mutation_p.E208*			O60304	ZN500_HUMAN	zinc finger protein 500	208					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	21						GACGCCATCTCCTGATGCCGG	0.662000													3	5					0.00024832	0.000277143	0.150653	1	0
FAM153B	202134	broad.mit.edu	37	5	175533569	175533569	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:175533569G>T	ENST00000253490.4	+	16	895	c.838G>T	c.(838-840)Gtg>Ttg	p.V280L	FAM153B_ENST00000510151.1_Missense_Mutation_p.V203L|FAM153B_ENST00000512862.1_Missense_Mutation_p.V71L|FAM153B_ENST00000515817.1_Missense_Mutation_p.V203L			P0C7A2	F153B_HUMAN	family with sequence similarity 153, member B	280										endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	16	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		CTAGATGCAGGTGGACCCAGC	0.463000													21	98					5.35356e-11	7.55299e-11	0.639603	1	0
ZC3H18	124245	broad.mit.edu	37	16	88644131	88644131	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:88644131A>G	ENST00000301011.5	+	2	800	c.600A>G	c.(598-600)atA>atG	p.I200M	ZC3H18_ENST00000452588.2_Missense_Mutation_p.I200M	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	200						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		ATGGGGAAATAGACGTGAGTA	0.537000													7	55					0	0	0.278610	0	0
PASK	23178	broad.mit.edu	37	2	242078153	242078153	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:242078153C>A	ENST00000403638.3	-	5	748	c.657G>T	c.(655-657)agG>agT	p.R219S	PASK_ENST00000539818.1_Missense_Mutation_p.R3S|PASK_ENST00000358649.4_Missense_Mutation_p.R219S|PASK_ENST00000544142.1_Missense_Mutation_p.R33S|PASK_ENST00000405260.1_Missense_Mutation_p.R219S|PASK_ENST00000234040.4_Missense_Mutation_p.R219S	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	219					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CCTGCCGCATCCTCTTCATCC	0.572000													8	62					0.000157383	0.000177874	0.278610	1	0
CLCN1	1180	broad.mit.edu	37	7	143039219	143039219	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:143039219G>T	ENST00000343257.2	+	15	1867	c.1780G>T	c.(1780-1782)Ggc>Tgc	p.G594C		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	594					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GCCTGACCTTGGCTGGAACCA	0.537000													7	37					7.48243e-07	9.26043e-07	0.335167	1	0
PRR16	51334	broad.mit.edu	37	5	120021925	120021925	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:120021925C>G	ENST00000379551.2	+	3	724	c.367C>G	c.(367-369)Cct>Gct	p.P123A	PRR16_ENST00000446965.1_Missense_Mutation_p.P76A|PRR16_ENST00000407149.2_Missense_Mutation_p.P146A|PRR16_ENST00000505123.1_Missense_Mutation_p.P76A	NM_016644.1	NP_057728.1	Q569H4	PRR16_HUMAN	proline rich 16	146	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		AACTGCCAATCCTGTAAAAAC	0.483000													11	38					0	0	0.361761	0	0
NTM	50863	broad.mit.edu	37	11	132081930	132081930	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:132081930G>C	ENST00000374786.1	+	3	894	c.415G>C	c.(415-417)Gta>Cta	p.V139L	NTM_ENST00000474900.1_3'UTR|NTM_ENST00000539799.1_Missense_Mutation_p.V139L|NTM_ENST00000374791.3_Missense_Mutation_p.V139L|NTM_ENST00000425719.2_Missense_Mutation_p.V139L|NTM_ENST00000427481.2_Missense_Mutation_p.V130L|NTM_ENST00000374784.1_Missense_Mutation_p.V139L	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	139	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						TCCCAAAATTGTAGAGATTTC	0.393000													4	35					0	0	0.150653	0	0
ACVRL1	94	broad.mit.edu	37	12	52308279	52308279	+	Missense_Mutation	SNP	G	G	A	rs138048445		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:52308279G>A	ENST00000550683.1	+	5	825	c.724G>A	c.(724-726)Gtc>Atc	p.V242I	ACVRL1_ENST00000388922.4_Missense_Mutation_p.V228I|ACVRL1_ENST00000419526.2_Missense_Mutation_p.V54I	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	228	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GAGTGTGGCCGTCAAGATCTT	0.567000													4	25					0	0	0.150653	0	0
IQCH	64799	broad.mit.edu	37	15	67768065	67768065	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:67768065C>G	ENST00000335894.4	+	18	2774	c.2708C>G	c.(2707-2709)aCc>aGc	p.T903S	IQCH-AS1_ENST00000559298.1_lincRNA|IQCH_ENST00000360277.4_Missense_Mutation_p.T564S|IQCH_ENST00000358767.3_Missense_Mutation_p.T639S|IQCH_ENST00000546225.1_Missense_Mutation_p.T560S	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	903										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		GCAGTGATGACCACCCAGCTA	0.413000													4	41					0	0	0.217242	0	0
MYO1B	4430	broad.mit.edu	37	2	192261175	192261175	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:192261175G>A	ENST00000392318.3	+	21	2494	c.2247G>A	c.(2245-2247)caG>caA	p.Q749Q	MYO1B_ENST00000392316.1_Silent_p.Q749Q|MYO1B_ENST00000339514.4_Silent_p.Q749Q|MYO1B_ENST00000304164.4_Silent_p.Q749Q|MYO1B_ENST00000439065.2_Silent_p.Q23Q	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	749						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GGTACCAGCAGACAAAGAGTT	0.378000													16	98					0	0	0.557998	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735884	55735884	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:55735884A>C	ENST00000312345.2	-	1	106	c.56T>G	c.(55-57)tTt>tGt	p.F19C		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AAATATACTAAAAAGCATCCA	0.338000													4	48					0	0	0.150653	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73067273	73067273	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:73067273G>T	ENST00000263674.3	+	6	4067	c.3717G>T	c.(3715-3717)gaG>gaT	p.E1239D		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1239	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						TCCTGCTGGAGGCGCAGCGGA	0.637000													6	28					0.00116845	0.00127226	0.217242	1	0
MEGF8	1954	broad.mit.edu	37	19	42875540	42875540	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:42875540A>T	ENST00000334370.4	+	40	7609	c.6974A>T	c.(6973-6975)cAg>cTg	p.Q2325L	MEGF8_ENST00000251268.6_Missense_Mutation_p.Q2392L|MEGF8_ENST00000378073.4_Intron	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2392						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				TGTAACGAGCAGGATGGGACG	0.602000													5	33					0	0	0.184627	0	0
OR10P1	121130	broad.mit.edu	37	12	56031201	56031201	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:56031201C>T	ENST00000309675.2	+	1	558	c.526C>T	c.(526-528)Ccg>Tcg	p.P176S		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						CCCGATCATCCCGCACTTTCT	0.562000													34	64					0	0	0.796494	0	0
OR14A16	284532	broad.mit.edu	37	1	247978926	247978926	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:247978926C>A	ENST00000357627.1	-	1	105	c.106G>T	c.(106-108)Gcc>Tcc	p.A36S		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						CCCATCAGGGCACACAAATAA	0.373000													24	43					6.44725e-10	8.87562e-10	0.624587	1	0
CD38	952	broad.mit.edu	37	4	15780059	15780059	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:15780059C>A	ENST00000226279.2	+	1	159	c.22C>A	c.(22-24)Ccg>Acg	p.P8T		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	8					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						CGAGTTCAGCCCGGTGTCCGG	0.642000													4	63					0.000602214	0.000664989	0.184627	1	0
SSTR1	6751	broad.mit.edu	37	14	38679184	38679184	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:38679184G>T	ENST00000267377.2	+	3	1207	c.590G>T	c.(589-591)cGc>cTc	p.R197L		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	197					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GTCTTCTCTCGCACCGCGGCC	0.632000													21	27					5.26018e-13	7.92195e-13	0.608945	1	0
NFIC	4782	broad.mit.edu	37	19	3381910	3381910	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:3381910G>T	ENST00000589123.1	+	2	324	c.204G>T	c.(202-204)ctG>ctT	p.L68L	NFIC_ENST00000443272.2_Silent_p.L77L|NFIC_ENST00000395111.3_Silent_p.L68L|NFIC_ENST00000346156.5_Silent_p.L68L|NFIC_ENST00000590282.1_Silent_p.L77L|NFIC_ENST00000586919.1_Silent_p.L68L|NFIC_ENST00000341919.3_Silent_p.L77L	NM_001245005.1|NM_205843.2	NP_001231934.1|NP_995315.1	P08651	NFIC_HUMAN	nuclear factor I/C (CCAAT-binding transcription factor)	77					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		CGCGGCTGCTGGCCAAGCTGC	0.672000													33	32					3.93418e-24	6.94594e-24	0.796494	1	0
MAB21L2	10586	broad.mit.edu	37	4	151505160	151505160	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:151505160T>A	ENST00000317605.4	+	1	2084	c.979T>A	c.(979-981)Ttt>Att	p.F327I	LRBA_ENST00000507224.1_Intron|LRBA_ENST00000535741.1_Intron|LRBA_ENST00000510413.1_Intron|LRBA_ENST00000357115.3_Intron	NM_006439.4	NP_006430.1	Q9Y586	MB212_HUMAN	mab-21-like 2 (C. elegans)	327					nervous system development	nucleus				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	21	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		CCTCGACCTCTTTCAGGGCAA	0.607000													11	11					0	0	0.361761	0	0
ENTHD1	150350	broad.mit.edu	37	22	40161345	40161345	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:40161345A>G	ENST00000325157.6	-	6	1352	c.1102T>C	c.(1102-1104)Tct>Cct	p.S368P		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	368										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					AATGAGGGAGAGAGACAGAGT	0.418000													16	39					0	0	0.520397	0	0
NPY5R	4889	broad.mit.edu	37	4	164271630	164271630	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:164271630A>T	ENST00000515560.1	+	4	1727	c.205A>T	c.(205-207)Aag>Tag	p.K69*	NPY5R_ENST00000506953.1_Nonsense_Mutation_p.K69*|NPY5R_ENST00000338566.3_Nonsense_Mutation_p.K69*			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	69					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				TCTCATGAAAAAGCGTAATCA	0.393000													21	140					0	0	0.608945	0	0
EOMES	8320	broad.mit.edu	37	3	27758988	27758988	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:27758988A>C	ENST00000295743.4	-	6	1837	c.1634T>G	c.(1633-1635)tTg>tGg	p.L545W	EOMES_ENST00000537516.1_Missense_Mutation_p.L269W|EOMES_ENST00000449599.1_Missense_Mutation_p.L564W			O95936	EOMES_HUMAN	eomesodermin	545					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						ATATGGGAGCAATGTGCTAGA	0.532000													43	47					0	0	0.834066	0	0
ERBB3	2065	broad.mit.edu	37	12	56495712	56495712	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:56495712A>T	ENST00000267101.3	+	28	4342	c.3902A>T	c.(3901-3903)cAg>cTg	p.Q1301L	ERBB3_ENST00000553131.1_Missense_Mutation_p.Q542L|ERBB3_ENST00000450146.2_Missense_Mutation_p.Q658L|RP11-603J24.9_ENST00000548861.1_Intron|ERBB3_ENST00000415288.2_Missense_Mutation_p.Q1242L|ERBB3_ENST00000549832.1_Missense_Mutation_p.Q421L	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1301					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCTGGACATCAGGCCCCCCAT	0.537000													54	94					0	0	0.870114	0	0
KIF4B	285643	broad.mit.edu	37	5	154396290	154396290	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:154396290A>G	ENST00000435029.4	+	1	3031	c.2871A>G	c.(2869-2871)caA>caG	p.Q957Q		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	957	Interaction with PRC1 (By similarity).			Q -> P (in Ref. 1; AF241316).	axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAAAGGAACAACAGCTGGTGA	0.468000													5	41					0	0	0.217242	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74742846	74742846	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:74742846C>A	ENST00000541184.1	-	1	491	c.14G>T	c.(13-15)tGg>tTg	p.W5L	ZDHHC15_ENST00000373367.3_Missense_Mutation_p.W5L|ZDHHC15_ENST00000373361.3_Missense_Mutation_p.W5L	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	5						integral to membrane	zinc ion binding	p.W5*(1)		central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						AGCCATCTTCCAGCCTCGCCG	0.662000													8	7					5.18039e-06	6.19072e-06	0.278610	1	0
NUMA1	4926	broad.mit.edu	37	11	71726319	71726319	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:71726319G>A	ENST00000393695.3	-	15	2561	c.2230C>T	c.(2230-2232)Cga>Tga	p.R744*	NUMA1_ENST00000351960.6_Intron|NUMA1_ENST00000358965.6_Nonsense_Mutation_p.R744*|RP11-849H4.4_ENST00000502284.1_RNA	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	744					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						ACCAGGCTTCGGGTCTCTGCC	0.602000			T	RARA	APL								8	92					0	0	0.278610	0	0
TTC37	9652	broad.mit.edu	37	5	94872822	94872822	+	Silent	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:94872822T>A	ENST00000358746.2	-	9	865	c.567A>T	c.(565-567)gcA>gcT	p.A189A		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	189							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						ATAATCCCAGTGCATTCTCAA	0.294000													7	50					0	0	0.278610	0	0
ZNF608	57507	broad.mit.edu	37	5	123980334	123980334	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:123980334C>T	ENST00000306315.5	-	5	4161	c.3726G>A	c.(3724-3726)tgG>tgA	p.W1242*	ZNF608_ENST00000504926.1_Nonsense_Mutation_p.W815*	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1242						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CATAATGATGCCATGTTCTTG	0.308000													6	16					0	0	0.217242	0	0
KRT75	9119	broad.mit.edu	37	12	52827729	52827729	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:52827729G>T	ENST00000252245.5	-	1	580	c.360C>A	c.(358-360)ggC>ggA	p.G120G		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	120	Gly-rich.|Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		CCTCTTGGATGCCTCCAGGGG	0.612000													32	47					2.70662e-09	3.67747e-09	0.740014	1	0
SETD5	55209	broad.mit.edu	37	3	9517226	9517226	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:9517226C>T	ENST00000402466.1	+	24	4254	c.3486C>T	c.(3484-3486)tcC>tcT	p.S1162S	SETD5_ENST00000406341.1_Silent_p.S1260S|SETD5_ENST00000302463.6_Silent_p.S1162S|SETD5_ENST00000407969.1_Silent_p.S1279S|SETD5_ENST00000402198.1_Silent_p.S1260S			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1260	Ser-rich.									NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGAGTTCCTCCCCCTTCAGAG	0.512000													19	28					0	0	0.592651	0	0
SULT4A1	25830	broad.mit.edu	37	22	44237700	44237700	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:44237700C>T	ENST00000330884.4	-	2	402	c.282G>A	c.(280-282)ccG>ccA	p.P94P	SULT4A1_ENST00000249130.5_Silent_p.P94P|SULT4A1_ENST00000540422.1_Intron	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	94					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		TGTCCAGGCCCGGCTGTGGGT	0.582000													15	31					0	0	0.500413	0	0
C16orf3	750	broad.mit.edu	37	16	90095617	90095617	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:90095617G>T	ENST00000408886.2	-	1	692	c.134C>A	c.(133-135)gCc>gAc	p.A45D	GAS8_ENST00000540721.1_Intron|GAS8_ENST00000536122.1_Intron|GAS8_ENST00000268699.4_Intron	NM_001214.3	NP_001205.3	O95177	CP003_HUMAN	chromosome 16 open reading frame 3	45										large_intestine(1)|lung(2)|prostate(1)	4		all_cancers(9;9.01e-08)|Hepatocellular(780;0.000325)|Lung NSC(15;0.0104)|all_lung(18;0.0239)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		tacggggcaggctacggggca	0.677000													6	16					8.12818e-05	9.2534e-05	0.248553	1	0
ZNF792	126375	broad.mit.edu	37	19	35450390	35450390	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:35450390C>A	ENST00000404801.1	-	4	755	c.369G>T	c.(367-369)gaG>gaT	p.E123D	ZNF792_ENST00000605484.1_Missense_Mutation_p.E56D	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACAGAGTTGCCTCGGGACTCC	0.502000													37	47					2.20474e-14	3.42776e-14	0.788014	1	0
TNIP2	79155	broad.mit.edu	37	4	2746465	2746465	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:2746465G>C	ENST00000510267.1	-	4	971	c.544C>G	c.(544-546)Cgg>Ggg	p.R182G	TNIP2_ENST00000505186.1_5'UTR|TNIP2_ENST00000315423.7_Missense_Mutation_p.R289G|TNIP2_ENST00000503235.1_Intron	NM_001161527.1	NP_001154999.1	Q8NFZ5	TNIP2_HUMAN	TNFAIP3 interacting protein 2	289						cytosol	protein binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(6)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCAGCATCCCGGGCCGTCCTG	0.617000													6	40					0	0	0.217242	0	0
USH2A	7399	broad.mit.edu	37	1	216373105	216373105	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:216373105G>T	ENST00000366943.2	-	17	4061	c.3675C>A	c.(3673-3675)agC>agA	p.S1225R	USH2A_ENST00000307340.3_Missense_Mutation_p.S1225R|USH2A_ENST00000366942.3_Missense_Mutation_p.S1225R|RP5-1099E6.3_ENST00000420867.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1225	Fibronectin type-III 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AACAGCCCCCGCTAGTACACG	0.493000										HNSCC(13;0.011)			7	56					8.12818e-05	9.2534e-05	0.248553	1	0
TULP4	56995	broad.mit.edu	37	6	158924188	158924188	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:158924188C>T	ENST00000367097.3	+	13	4850	c.3493C>T	c.(3493-3495)Cga>Tga	p.R1165*	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	1165					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity	p.R1165*(1)		endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GGACGTGTCCCGACTGCCCTT	0.557000													23	87					0	0	0.667858	0	0
LTBP2	4053	broad.mit.edu	37	14	74975651	74975651	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:74975651C>T	ENST00000261978.4	-	23	3794	c.3408G>A	c.(3406-3408)gtG>gtA	p.V1136V	LTBP2_ENST00000556690.1_Silent_p.V1136V	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1136	Cys-rich.|EGF-like 11; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CACATTCATCCACATCTGCAG	0.622000													17	59					0	0	0.500413	0	0
JUN	3725	broad.mit.edu	37	1	59248487	59248487	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:59248487C>A	ENST00000371222.2	-	1	1298	c.256G>T	c.(256-258)Ggg>Tgg	p.G86W		NM_002228.3	NP_002219.1	P05412	JUN_HUMAN	jun proto-oncogene	86					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation by host of viral transcription|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein import into nucleus|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway		R-SMAD binding|Rho GTPase activator activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|kidney(2)|lung(5)|skin(1)	10	all_cancers(7;8.55e-07)				Arsenic trioxide(DB01169)|Irbesartan(DB01029)|Vinblastine(DB00570)	GTGATGTGCCCGTTGCTGGAC	0.677000			A		sarcoma								50	72					6.3091e-27	1.13637e-26	0.870114	1	0
OR52N4	390072	broad.mit.edu	37	11	5776004	5776004	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:5776004G>T	ENST00000317254.3	+	1	82	c.34G>T	c.(34-36)Gct>Tct	p.A12S	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CCTAATACCAGCTTCATTTAT	0.383000													29	26					1.88708e-17	3.12018e-17	0.729181	1	0
ANKRD33	341405	broad.mit.edu	37	12	52282850	52282850	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:52282850G>T	ENST00000301190.6	+	3	623		c.e3-1		ANKRD33_ENST00000538991.1_Intron|ANKRD33_ENST00000547119.1_Intron|ANKRD33_ENST00000340970.4_Intron	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33											endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CCCTCCCTCAGACAGGCCTCA	0.612000													12	42					7.03913e-09	9.42067e-09	0.411799	1	0
GYPE	2996	broad.mit.edu	37	4	144826671	144826671	+	Translation_Start_Site	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:144826671C>T	ENST00000358615.4	-	0	41				GYPE_ENST00000437468.2_De_novo_Start_OutOfFrame	NM_198682.2	NP_941391.2	P15421	GLPE_HUMAN	glycophorin E (MNS blood group)							integral to plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5	all_hematologic(180;0.158)					CCTGAGATCACGAGCTGGCTC	0.398000													7	43					0	0	0.248553	0	0
SHANK1	50944	broad.mit.edu	37	19	51165488	51165488	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:51165488G>T	ENST00000293441.1	-	23	6238	c.6220C>A	c.(6220-6222)Cgc>Agc	p.R2074S	SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000391814.1_Missense_Mutation_p.R2082S|SHANK1_ENST00000391813.1_Missense_Mutation_p.R1461S|SHANK1_ENST00000359082.3_Missense_Mutation_p.R2065S	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2074					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GAGAGGGAGCGCGAGGCCCCT	0.682000													7	16					7.48243e-07	9.26043e-07	0.335167	1	0
OR14A16	284532	broad.mit.edu	37	1	247978659	247978659	+	Missense_Mutation	SNP	A	A	T	rs139200041	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:247978659A>T	ENST00000357627.1	-	1	372	c.373T>A	c.(373-375)Tgt>Agt	p.C125S		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						AGAGGGTGACATATAGCAGTA	0.502000													40	88					0	0	0.827153	0	0
WWC1	23286	broad.mit.edu	37	5	167850742	167850742	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:167850742G>T	ENST00000265293.4	+	11	1981	c.1479G>T	c.(1477-1479)cgG>cgT	p.R493R	WWC1_ENST00000521089.1_Silent_p.R493R	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	493					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CCGGCTTCCGGCCCTCAGGCT	0.632000													7	27					0.00198382	0.00214513	0.248553	1	0
METTL20	254013	broad.mit.edu	37	12	31819092	31819092	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:31819092C>T	ENST00000357721.3	+	3	601	c.386C>T	c.(385-387)aCa>aTa	p.T129I	METTL20_ENST00000538463.1_Missense_Mutation_p.T129I|METTL20_ENST00000395763.3_Missense_Mutation_p.T129I|METTL20_ENST00000412352.2_Missense_Mutation_p.T129I|METTL20_ENST00000538391.1_Intron	NM_001135863.1	NP_001129335.1	Q8IXQ9	MET20_HUMAN	methyltransferase like 20	129						cytoplasm	protein methyltransferase activity			lung(2)|stomach(1)	3						TGTGGAGCTACAGCTATTGCT	0.373000													9	80					0	0	0.335167	0	0
CPAMD8	27151	broad.mit.edu	37	19	17091417	17091417	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:17091417C>T	ENST00000443236.1	-	14	1647	c.1616G>A	c.(1615-1617)gGc>gAc	p.G539D	CPAMD8_ENST00000388925.4_Intron	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	492			D -> E (in dbSNP:rs3745335).			extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CACAATATTGCCCCGTGCAGC	0.562000													3	52					0	0	0.115264	0	0
PCDHB7	56129	broad.mit.edu	37	5	140552519	140552519	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:140552519G>T	ENST00000231137.3	+	1	277	c.103G>T	c.(103-105)Gtg>Ttg	p.V35L		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		35	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGTATTTTGTGGCGGAGGA	0.522000													15	45					2.31682e-05	2.69649e-05	0.479597	1	0
GNL1	2794	broad.mit.edu	37	6	30515033	30515033	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:30515033G>C	ENST00000376621.3	-	10	2267	c.1297C>G	c.(1297-1299)Cct>Gct	p.P433A		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	433					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						TGGGCGATAGGGTAGATCCCT	0.597000													12	175					0	0	0.411799	0	0
ZWILCH	55055	broad.mit.edu	37	15	66807973	66807973	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:66807973G>C	ENST00000307897.5	+	4	691	c.311G>C	c.(310-312)gGg>gCg	p.G104A	ZWILCH_ENST00000565960.1_3'UTR|ZWILCH_ENST00000535141.2_5'UTR|ZWILCH_ENST00000565627.1_5'UTR|ZWILCH_ENST00000446801.2_5'UTR|RPL4_ENST00000568588.1_Intron|RPL4_ENST00000564517.1_Intron	NM_017975.3	NP_060445.3	Q9H900	ZWILC_HUMAN	zwilch kinetochore protein	104					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(1)|lung(6)|ovary(1)	18						TTACCAGTTGGGAAGGCAAGG	0.398000													6	32					0	0	0.278610	0	0
RMND1	55005	broad.mit.edu	37	6	151744707	151744707	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:151744707T>C	ENST00000367303.4	-	7	1012	c.890A>G	c.(889-891)gAt>gGt	p.D297G	RMND1_ENST00000336451.3_Missense_Mutation_p.D86G	NM_017909.2	NP_060379.2	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog (S. cerevisiae)	297										central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		TAGAATGGCATCATCTAAATC	0.383000													17	130					0	0	0.539581	0	0
IL12RB2	3595	broad.mit.edu	37	1	67845698	67845698	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:67845698C>A	ENST00000262345.1	+	13	2387	c.1747C>A	c.(1747-1749)Cat>Aat	p.H583N	IL12RB2_ENST00000465396.1_3'UTR|IL12RB2_ENST00000371000.1_Missense_Mutation_p.H583N|IL12RB2_ENST00000541374.1_Missense_Mutation_p.H583N|IL12RB2_ENST00000544434.1_Missense_Mutation_p.H497N	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	583	Fibronectin type-III 5.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						CCAAAATTCACATCCAATAAA	0.433000													30	30					6.38683e-12	9.3924e-12	0.729181	1	0
HTR1A	3350	broad.mit.edu	37	5	63256904	63256904	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:63256904A>G	ENST00000323865.3	-	1	876	c.643T>C	c.(643-645)Tat>Cat	p.Y215H	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	215					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ATGCGCCCATAGAGAACCAGC	0.582000													33	97					0	0	0.769981	0	0
DST	667	broad.mit.edu	37	6	56362216	56362216	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:56362216A>T	ENST00000370754.5	-	82	20090	c.20091T>A	c.(20089-20091)ggT>ggA	p.G6697G	DST_ENST00000244364.6_Silent_p.G4105G|DST_ENST00000370769.4_Silent_p.G6519G|DST_ENST00000370788.2_Silent_p.G4322G|DST_ENST00000361203.3_Silent_p.G6408G|DST_ENST00000421834.2_Silent_p.G4431G|DST_ENST00000446842.2_Silent_p.G6193G|DST_ENST00000312431.6_3'UTR|DST_ENST00000340834.4_5'UTR			Q03001	DYST_HUMAN	dystonin	6517					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTCCGGTAAACCTCCCAGCG	0.463000													4	37					0	0	0.184627	0	0
MARK2	2011	broad.mit.edu	37	11	63665752	63665752	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:63665752G>T	ENST00000402010.2	+	4	916	c.337_splice	c.e4+1	p.V113_splice	MARK2_ENST00000408948.3_Splice_Site_p.V80_splice|MARK2_ENST00000315032.8_Splice_Site_p.V113_splice|MARK2_ENST00000502399.3_Splice_Site_p.V113_splice|MARK2_ENST00000377810.3_Splice_Site_p.V80_splice|MARK2_ENST00000361128.5_Splice_Site_p.V113_splice|MARK2_ENST00000413835.2_Splice_Site_p.V113_splice|MARK2_ENST00000509502.2_Splice_Site_p.V80_splice|MARK2_ENST00000508192.1_Splice_Site_p.V113_splice|MARK2_ENST00000513765.2_Splice_Site_p.V80_splice|MARK2_ENST00000377809.4_Splice_Site_p.V113_splice|MARK2_ENST00000425897.2_Splice_Site_p.V80_splice|MARK2_ENST00000350490.7_Splice_Site_p.V113_splice	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	113	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						TCCCAACATAGGTGAGCACAA	0.478000													15	148					1.37285e-15	2.20009e-15	0.500413	1	0
ANO1	55107	broad.mit.edu	37	11	69978181	69978181	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:69978181C>T	ENST00000355303.5	+	11	1559	c.1254C>T	c.(1252-1254)ctC>ctT	p.L418L	ANO1_ENST00000538023.1_Silent_p.L418L|RP11-805J14.3_ENST00000530525.1_RNA|ANO1_ENST00000531349.1_Silent_p.L153L|ANO1_ENST00000530676.1_Silent_p.L302L|ANO1_ENST00000398543.2_Silent_p.L302L|ANO1_ENST00000316296.5_Silent_p.L390L	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	418					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TCATGGCCCTCTGGGGTAAGC	0.597000													10	1					0	0	0.411799	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923271	43923271	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:43923271C>T	ENST00000329196.5	+	1	1016	c.999C>T	c.(997-999)acC>acT	p.T333T	MAPT-AS1_ENST00000579244.1_RNA|MAPT-AS1_ENST00000579599.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	333						integral to membrane	aspartic-type endopeptidase activity										TGTGCGCAACCGTGATCATCT	0.652000													17	40					0	0	0.539581	0	0
HVCN1	84329	broad.mit.edu	37	12	111099122	111099122	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:111099122C>T	ENST00000356742.5	-	3	906	c.153G>A	c.(151-153)gaG>gaA	p.E51E	HVCN1_ENST00000548312.1_Silent_p.E51E|HVCN1_ENST00000439744.2_Silent_p.E31E|HVCN1_ENST00000242607.8_Silent_p.E51E			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	51	Poly-Glu.				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						cctcctcctcctcctcctctt	0.607000													21	32					0	0	0.592651	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276985	71276985	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:71276985G>T	ENST00000398531.1	+	1	377	c.352G>T	c.(352-354)Ggg>Tgg	p.G118W	KRTAP5-10_ENST00000376536.4_Intron	NM_001012710.1	NP_001012728.1	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	118	7 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(2)|large_intestine(1)|lung(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	12						TGGCTCCTGTGGGGGCTCCAA	0.662000													12	133					2.31682e-05	2.69649e-05	0.479597	1	0
ESCO1	114799	broad.mit.edu	37	18	19146168	19146168	+	Splice_Site	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:19146168C>T	ENST00000269214.5	-	6	2583		c.e6-1			NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1						cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						GGAGCTGAACCTGTAATTTAA	0.299000													56	108					0	0	0.870114	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319267	21319267	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:21319267C>A	ENST00000583088.1	+	3	1508	c.613C>A	c.(613-615)Cgt>Agt	p.R205S	KCNJ12_ENST00000331718.5_Missense_Mutation_p.R205S	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GGTGGCCCTGCGTGACGGCAA	0.622000										Prostate(3;0.18)			4	34					0.00909568	0.00958651	0.150653	1	0
PLXNA4	91584	broad.mit.edu	37	7	131848984	131848984	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:131848984G>T	ENST00000359827.3	-	24	5379	c.4417C>A	c.(4417-4419)Ccc>Acc	p.P1473T	PLXNA4_ENST00000321063.4_Missense_Mutation_p.P1473T			Q9HCM2	PLXA4_HUMAN	plexin A4	1473						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCGTCAATGGGGCCCTTCTCC	0.587000													16	14					1.5739e-10	2.19084e-10	0.500413	1	0
PID1	55022	broad.mit.edu	37	2	229890413	229890413	+	Missense_Mutation	SNP	C	C	A	rs142605695	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:229890413C>A	ENST00000392054.3	-	4	1021	c.682G>T	c.(682-684)Ggg>Tgg	p.G228W	PID1_ENST00000482518.2_Intron|PID1_ENST00000354069.6_Missense_Mutation_p.G230W|PID1_ENST00000409462.1_Missense_Mutation_p.G148W|PID1_ENST00000392055.3_Missense_Mutation_p.G197W	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	230	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		TGGATCCGCCCGTCGCTCTTC	0.562000													5	71					0.0215528	0.0225259	0.217242	1	0
MYLK4	340156	broad.mit.edu	37	6	2679629	2679629	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:2679629C>A	ENST00000274643.7	-	9	1114	c.772G>T	c.(772-774)Gag>Tag	p.E258*	MYLK4_ENST00000268446.5_Nonsense_Mutation_p.E258*	NM_001012418.3	NP_001012418.2	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	258	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				TTCAGCTTCTCTCTGGGTTTG	0.423000													90	154					1.13049e-35	2.09041e-35	0.870114	1	0
SLC6A15	55117	broad.mit.edu	37	12	85255558	85255558	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:85255558C>A	ENST00000266682.5	-	12	2587	c.2046G>T	c.(2044-2046)ccG>ccT	p.P682P	SLC6A15_ENST00000552192.1_Silent_p.P575P|SLC6A15_ENST00000309283.7_3'UTR	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	682					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						GCATCTCGCTCGGTATTTTTC	0.443000													69	84					4.37588e-27	7.90441e-27	0.870114	1	0
OR8K1	390157	broad.mit.edu	37	11	56114150	56114150	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:56114150T>A	ENST00000279783.2	+	1	730	c.636T>A	c.(634-636)aaT>aaA	p.N212K		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					CAGGCTGTAATTTGCTCTTCT	0.373000										HNSCC(65;0.19)			37	31					0	0	0.804634	0	0
ABHD12	26090	broad.mit.edu	37	20	25300871	25300871	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:25300871G>C	ENST00000339157.5	-	4	778	c.506C>G	c.(505-507)cCt>cGt	p.P169R	ABHD12_ENST00000376542.3_Missense_Mutation_p.P169R	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	169						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						CAGAATGATAGGGTGGCTGGA	0.562000													4	33					0	0	0.150653	0	0
EPHA7	2045	broad.mit.edu	37	6	93969119	93969119	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:93969119T>A	ENST00000369303.4	-	10	2061	c.1877A>T	c.(1876-1878)aAg>aTg	p.K626M		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	626						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		ATCTAGCTCCTTGGCGAATTG	0.428000													22	41					0	0	0.592651	0	0
ZNF681	148213	broad.mit.edu	37	19	23938261	23938261	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:23938261C>A	ENST00000402377.3	-	2	237	c.96G>T	c.(94-96)gtG>gtT	p.V32V	ZNF681_ENST00000395385.3_Intron	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TCTCTAACATCACATTCCTAT	0.358000													32	118					4.4194e-11	6.29186e-11	0.769981	1	0
RET	5979	broad.mit.edu	37	10	43606872	43606872	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:43606872G>T	ENST00000355710.3	+	7	1713	c.1481G>T	c.(1480-1482)aGg>aTg	p.R494M	RET_ENST00000340058.5_Missense_Mutation_p.R494M	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	494					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	CAGACCTCTAGGCAGGCCCAG	0.647000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				11	23					0.000673444	0.000742332	0.361761	1	0
CNTN1	1272	broad.mit.edu	37	12	41408078	41408078	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:41408078G>C	ENST00000551295.2	+	18	2279	c.2162G>C	c.(2161-2163)aGa>aCa	p.R721T	CNTN1_ENST00000348761.2_Missense_Mutation_p.R710T|CNTN1_ENST00000550305.1_3'UTR|CNTN1_ENST00000347616.1_Missense_Mutation_p.R721T	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	721	Fibronectin type-III 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GGAAGAAACAGAGAGCTGACC	0.398000													5	38					0	0	0.217242	0	0
IGLV2-11	28816	broad.mit.edu	37	22	23135477	23135477	+	RNA	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:23135477A>T	ENST00000390314.2	+	0	381																											GCTCATATGCAGGCAGCTACA	0.552000													31	101					0	0	0.740014	0	0
PLAA	9373	broad.mit.edu	37	9	26905785	26905785	+	Silent	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:26905785T>C	ENST00000397292.3	-	14	2529	c.2112A>G	c.(2110-2112)acA>acG	p.T704T		NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	704	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TCAGGGCCAATGTAGCCAGAG	0.403000													7	38					0	0	0.278610	0	0
TAF7L	54457	broad.mit.edu	37	X	100537379	100537379	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:100537379A>G	ENST00000372907.3	-	5	611	c.600T>C	c.(598-600)acT>acC	p.T200T	TAF7L_ENST00000356784.1_Silent_p.T114T|TAF7L_ENST00000324762.6_Silent_p.T114T|TAF7L_ENST00000372905.2_Silent_p.T114T	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	200					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						TATTAGGATCAGTAGAGGCAG	0.443000													33	28					0	0	0.788014	0	0
EPS8L2	64787	broad.mit.edu	37	11	721659	721659	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:721659A>G	ENST00000533256.1	+	11	1238	c.863A>G	c.(862-864)aAg>aGg	p.K288R	EPS8L2_ENST00000318562.8_Missense_Mutation_p.K288R|EPS8L2_ENST00000526198.1_Missense_Mutation_p.K304R|AP006621.9_ENST00000527021.2_RNA|EPS8L2_ENST00000530636.1_Missense_Mutation_p.K288R			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	288						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGCGGAAAAAGGGGAAGAAG	0.657000													3	38					0	0	0.150653	0	0
RBP3	5949	broad.mit.edu	37	10	48389088	48389088	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:48389088G>T	ENST00000224600.4	-	1	1903	c.1790C>A	c.(1789-1791)aCc>aAc	p.T597N		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	597	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GTCGATGAAGGTGAGGACCGG	0.672000													16	46					4.14922e-12	6.11618e-12	0.500413	1	0
PHOX2A	401	broad.mit.edu	37	11	71952179	71952179	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:71952179C>A	ENST00000298231.5	-	2	543	c.372G>T	c.(370-372)gcG>gcT	p.A124A	PHOX2A_ENST00000544057.1_5'UTR	NM_005169.3	NP_005160.2	O14813	PHX2A_HUMAN	paired-like homeobox 2a	124					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	5						CGATCTTGAGCGCCAGCTCCT	0.597000													7	30					1.06961e-07	1.38407e-07	0.278610	1	0
OR1L8	138881	broad.mit.edu	37	9	125330688	125330688	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:125330688C>T	ENST00000304865.2	-	1	150	c.69G>A	c.(67-69)gaG>gaA	p.E23E		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TCTTTTGGTCCTCAGGCCGGG	0.493000													8	31					0	0	0.278610	0	0
PCSK5	5125	broad.mit.edu	37	9	78682927	78682927	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:78682927C>G	ENST00000545128.1	+	6	1227	c.689C>G	c.(688-690)aCa>aGa	p.T230R	PCSK5_ENST00000376752.4_Missense_Mutation_p.T230R|PCSK5_ENST00000376767.3_Missense_Mutation_p.T230R	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	230	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TCGCACTGCACAGTCGGAATT	0.512000													20	56					0	0	0.557998	0	0
ZNF549	256051	broad.mit.edu	37	19	58042467	58042467	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:58042467A>T	ENST00000602149.1	+	2	211	c.63A>T	c.(61-63)aaA>aaT	p.K21N	ZNF549_ENST00000240719.3_Intron|ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000376233.3_Missense_Mutation_p.K21N			Q6P9A3	ZN549_HUMAN	zinc finger protein 549	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGTTTGTGAAACCATCACAGG	0.483000													9	62					0	0	0.361761	0	0
KRT13	3860	broad.mit.edu	37	17	39661353	39661353	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:39661353C>A	ENST00000246635.3	-	1	496	c.450G>T	c.(448-450)cgG>cgT	p.R150R	KRT13_ENST00000587544.1_Silent_p.R150R|KRT13_ENST00000336861.3_Silent_p.R150R	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	150	Linker 1.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				GGCTGTAGTCCCGCTCAGGGC	0.622000													33	42					2.08457e-15	3.30674e-15	0.750413	1	0
KIF13A	63971	broad.mit.edu	37	6	17809094	17809094	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:17809094T>A	ENST00000378814.5	-	18	2067	c.2068A>T	c.(2068-2070)Agg>Tgg	p.R690W	KIF13A_ENST00000259711.6_Missense_Mutation_p.R690W|KIF13A_ENST00000378843.2_Missense_Mutation_p.R690W|KIF13A_ENST00000378826.2_Missense_Mutation_p.R690W|KIF13A_ENST00000378816.5_Missense_Mutation_p.R690W	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	690					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTTGCTTCCCTCACCAAGGTA	0.478000													5	28					0	0	0.184627	0	0
MKL1	57591	broad.mit.edu	37	22	40814546	40814546	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:40814546G>A	ENST00000396617.3	-	12	2486	c.1896C>T	c.(1894-1896)ccC>ccT	p.P632P	MKL1_ENST00000402042.1_Silent_p.P582P|MKL1_ENST00000355630.3_Silent_p.P632P|MKL1_ENST00000407029.1_Silent_p.P632P			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	632	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						GGACCGGCTCGGGCTCAGGCT	0.701000			T	RBM15	acute megakaryocytic leukemia								7	24					0	0	0.248553	0	0
ARPC1B	10095	broad.mit.edu	37	7	98988802	98988802	+	Splice_Site	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:98988802G>A	ENST00000451682.1	+	9	1018	c.707_splice	c.e9-1	p.V237_splice	ARPC1B_ENST00000252725.5_Splice_Site_p.V237_splice			O15143	ARC1B_HUMAN	actin related protein 2/3 complex, subunit 1B, 41kDa	237					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(2)|lung(1)	11	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCCCCTCAGCGTCGCGACTCT	0.617000													3	16					0	0	0.150653	0	0
PCLO	27445	broad.mit.edu	37	7	82430869	82430869	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:82430869T>C	ENST00000333891.8	-	22	15309	c.14972A>G	c.(14971-14973)cAg>cGg	p.Q4991R		NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4914	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TACCCCTGGCTGTTTTACAGG	0.363000													18	34					0	0	0.624587	0	0
ZNF813	126017	broad.mit.edu	37	19	53994626	53994626	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:53994626G>A	ENST00000396403.4	+	4	1268	c.1140G>A	c.(1138-1140)gaG>gaA	p.E380E	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		ATACGGGAGAGAAACCTTATA	0.428000													62	67					0	0	0.870114	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136824	40136824	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:40136824T>C	ENST00000278198.2	-	2	2982	c.1019A>G	c.(1018-1020)tAc>tGc	p.Y340C	LRRC4C_ENST00000528697.1_Missense_Mutation_p.Y340C|LRRC4C_ENST00000527150.1_Missense_Mutation_p.Y340C|LRRC4C_ENST00000530763.1_Missense_Mutation_p.Y340C			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	340	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				CTCTCCAATGTACCTCCCCTT	0.532000													6	38					0	0	0.217242	0	0
KRT38	8687	broad.mit.edu	37	17	39596963	39596963	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:39596963G>T	ENST00000246646.3	-	1	210	c.211C>A	c.(211-213)Cct>Act	p.P71T		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	71	Head.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				TGGCAGGTAGGCGGCAGACAG	0.612000													20	50					3.62473e-10	5.00101e-10	0.608945	1	0
FREM1	158326	broad.mit.edu	37	9	14851557	14851557	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:14851557G>A	ENST00000380881.4	-	7	1695	c.880C>T	c.(880-882)Cag>Tag	p.Q294*	FREM1_ENST00000380880.3_Nonsense_Mutation_p.Q293*|FREM1_ENST00000422223.2_Nonsense_Mutation_p.Q293*			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	293					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TTTGGAATCTGATTCGGAATT	0.423000													29	77					0	0	0.788014	0	0
KIF21A	55605	broad.mit.edu	37	12	39726099	39726099	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:39726099C>A	ENST00000395670.3	-	21	3387	c.2968G>T	c.(2968-2970)Gag>Tag	p.E990*	KIF21A_ENST00000361418.5_Nonsense_Mutation_p.E990*|KIF21A_ENST00000544797.2_Nonsense_Mutation_p.E977*|KIF21A_ENST00000361961.3_Nonsense_Mutation_p.E977*|KIF21A_ENST00000541463.2_Nonsense_Mutation_p.E954*			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	990					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				GTCAGTGACTCCATCTCTTCA	0.358000													50	116					6.31075e-24	1.11105e-23	0.870114	1	0
VAMP3	9341	broad.mit.edu	37	1	7837301	7837301	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:7837301G>T	ENST00000054666.6	+	3	269	c.154G>T	c.(154-156)Gca>Tca	p.A52S	VAMP3_ENST00000470357.1_Missense_Mutation_p.A24S	NM_004781.3	NP_004772.1	Q15836	VAMP3_HUMAN	vesicle-associated membrane protein 3	52	v-SNARE coiled-coil homology.				cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CCGTGCAGACGCACTGCAGGC	0.463000													17	13					9.16793e-09	1.21914e-08	0.520397	1	0
OR10A3	26496	broad.mit.edu	37	11	7960514	7960514	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:7960514A>G	ENST00000360759.3	-	1	627	c.554T>C	c.(553-555)cTa>cCa	p.L185P		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CACAAGCTCTAGTACCGGGGG	0.433000													40	28					0	0	0.847076	0	0
LRRC45	201255	broad.mit.edu	37	17	79986492	79986492	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:79986492G>A	ENST00000306688.3	+	12	1583	c.1241G>A	c.(1240-1242)cGc>cAc	p.R414H		NM_144999.2	NP_659436.1	Q96CN5	LRC45_HUMAN	leucine rich repeat containing 45	414						centrosome				lung(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	5	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CTTCCAGAGCGCCTGGACATG	0.662000													9	20					0	0	0.335167	0	0
CABYR	26256	broad.mit.edu	37	18	21735868	21735868	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:21735868G>A	ENST00000399481.2	+	2	261	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	CABYR_ENST00000399496.3_Missense_Mutation_p.E135K|CABYR_ENST00000327201.6_Missense_Mutation_p.E37K|CABYR_ENST00000581397.1_Missense_Mutation_p.E135K|CABYR_ENST00000415309.2_Missense_Mutation_p.E135K|CABYR_ENST00000399499.1_Missense_Mutation_p.E135K			O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	135	RIIa.				ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					TGAGCAAACGGAAGCAGTTGG	0.493000													112	46					0	0	0.870114	0	0
SCAF11	9169	broad.mit.edu	37	12	46355595	46355595	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:46355595C>A	ENST00000369367.3	-	3	340	c.107G>T	c.(106-108)aGt>aTt	p.S36I	SCAF11_ENST00000419565.2_Missense_Mutation_p.S36I|SCAF11_ENST00000395453.2_Missense_Mutation_p.S36I|SCAF11_ENST00000395454.2_Missense_Mutation_p.S36I	NM_004719.2	NP_004710.2	Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	36					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GTCAGCCTCACTGTACAACAG	0.368000													26	48					3.17567e-06	3.81691e-06	0.729181	1	0
ATR	545	broad.mit.edu	37	3	142272122	142272122	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:142272122T>C	ENST00000350721.4	-	13	2873	c.2752A>G	c.(2752-2754)Aaa>Gaa	p.K918E	ATR_ENST00000383101.3_Missense_Mutation_p.K854E	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	918					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TTAACACTTTTAGCTGCAACC	0.408000								Other conserved DNA damage response genes					9	50					0	0	0.335167	0	0
HDAC9	9734	broad.mit.edu	37	7	18624995	18624995	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:18624995C>A	ENST00000406451.3	+	3	264	c.114C>A	c.(112-114)gaC>gaA	p.D38E	HDAC9_ENST00000441542.2_Missense_Mutation_p.D38E|HDAC9_ENST00000476135.1_3'UTR|HDAC9_ENST00000428307.2_Missense_Mutation_p.D38E|HDAC9_ENST00000524023.1_Missense_Mutation_p.D7E|HDAC9_ENST00000405010.3_Missense_Mutation_p.D38E|HDAC9_ENST00000417496.2_Missense_Mutation_p.D80E|HDAC9_ENST00000401921.1_Missense_Mutation_p.D38E|HDAC9_ENST00000432645.2_Missense_Mutation_p.D38E|HDAC9_ENST00000406072.1_Missense_Mutation_p.D66E|HDAC9_ENST00000456174.2_Missense_Mutation_p.D7E	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	38					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CCGTGGTGGACCCTGTTGTCC	0.493000													7	88					8.12818e-05	9.2534e-05	0.248553	1	0
PRRC2C	23215	broad.mit.edu	37	1	171482185	171482185	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:171482185G>A	ENST00000367742.3	+	3	406	c.164G>A	c.(163-165)cGt>cAt	p.R55H	PRRC2C_ENST00000392078.3_Missense_Mutation_p.R55H|PRRC2C_ENST00000338920.4_Missense_Mutation_p.R53H|PRRC2C_ENST00000426496.2_Missense_Mutation_p.R53H|PRRC2C_ENST00000476522.1_3'UTR			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	53							protein C-terminus binding										ATTTCACGGCGTATGCCTCCA	0.408000													8	44					0	0	0.335167	0	0
DCC	1630	broad.mit.edu	37	18	51025789	51025789	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:51025789C>A	ENST00000442544.2	+	27	4636	c.4020C>A	c.(4018-4020)caC>caA	p.H1340Q	RP11-671P2.1_ENST00000582064.1_RNA|DCC_ENST00000581580.1_Missense_Mutation_p.H973Q	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1340					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GACCAACTCACCCACTCCGCA	0.527000													27	44					9.78306e-22	1.69374e-21	0.740014	1	0
PIK3CG	5294	broad.mit.edu	37	7	106508180	106508180	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:106508180G>T	ENST00000359195.3	+	2	484	c.174G>T	c.(172-174)ctG>ctT	p.L58L	PIK3CG_ENST00000496166.1_Silent_p.L58L|PIK3CG_ENST00000440650.2_Silent_p.L58L	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	58					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding	p.L58L(1)		breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						AAACGGCGCTGCTGCACGTGG	0.682000													4	24					0.00024832	0.000277143	0.150653	1	0
NOD2	64127	broad.mit.edu	37	16	50733449	50733449	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:50733449G>A	ENST00000300589.2	+	2	229	c.124G>A	c.(124-126)Gtc>Atc	p.V42I	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	42	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GAGCCAGCTGGTCGAGCTGCT	0.602000													13	112					0	0	0.435327	0	0
CCDC63	160762	broad.mit.edu	37	12	111336756	111336756	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:111336756C>T	ENST00000308208.5	+	10	1411	c.1169C>T	c.(1168-1170)aCg>aTg	p.T390M	CCDC63_ENST00000552694.1_Missense_Mutation_p.T311M|CCDC63_ENST00000545036.1_Missense_Mutation_p.T350M	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	390										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						AGGAAGACCACGGAGGAGGCA	0.517000													8	47					0	0	0.278610	0	0
COL4A1	1282	broad.mit.edu	37	13	110822982	110822982	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:110822982C>T	ENST00000375820.4	-	42	3775	c.3654G>A	c.(3652-3654)caG>caA	p.Q1218Q		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1218	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCGGCTGTCCCTGGGGCCCCG	0.647000													7	15					0	0	0.307466	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128868217	128868217	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:128868217C>A	ENST00000310343.9	-	11	1149	c.1150G>T	c.(1150-1152)Gaa>Taa	p.E384*	ARHGAP32_ENST00000392657.3_Nonsense_Mutation_p.E35*|ARHGAP32_ENST00000527272.1_Nonsense_Mutation_p.E35*|ARHGAP32_ENST00000524655.1_Nonsense_Mutation_p.E310*	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	384	Rho-GAP.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TTTTTACCTTCAAAACCAGAA	0.403000													31	46					6.00712e-18	9.98524e-18	0.760397	1	0
DOCK2	1794	broad.mit.edu	37	5	169494579	169494579	+	Missense_Mutation	SNP	G	G	A	rs148502872	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:169494579G>A	ENST00000256935.8	+	45	4613	c.4533G>A	c.(4531-4533)atG>atA	p.M1511I	DOCK2_ENST00000520908.1_Missense_Mutation_p.M1003I|DOCK2_ENST00000540750.1_Missense_Mutation_p.M572I|DOCK2_ENST00000523351.1_3'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1511	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATCCTGATGATGATAAACC	0.502000													10	59					0	0	0.361761	0	0
RGPD4	285190	broad.mit.edu	37	2	108487926	108487926	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:108487926C>G	ENST00000408999.3	+	20	3543	c.3466C>G	c.(3466-3468)Ctg>Gtg	p.L1156V	RGPD4_ENST00000354986.4_Missense_Mutation_p.L1156V	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1156	RanBD1 1.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AACACCAGAGCTGGCTGAAGA	0.453000													15	163					0	0	0.479597	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773003	140773003	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:140773003A>G	ENST00000398604.2	+	1	623	c.623A>G	c.(622-624)cAc>cGc	p.H208R	PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGCTGCTCACCACCTGGTC	0.602000													10	22					0	0	0.387290	0	0
FOXN4	121643	broad.mit.edu	37	12	109723224	109723224	+	Silent	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:109723224G>C	ENST00000299162.5	-	8	890	c.786C>G	c.(784-786)tcC>tcG	p.S262S	FOXN4_ENST00000355216.1_Silent_p.S82S	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	262					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						AGCCCTTGCGGGAGGAGCCGC	0.602000													8	24					0	0	0.278610	0	0
IFT122	55764	broad.mit.edu	37	3	129195584	129195584	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:129195584T>C	ENST00000296266.3	+	12	1432	c.1240T>C	c.(1240-1242)Tat>Cat	p.Y414H	IFT122_ENST00000507564.1_Missense_Mutation_p.Y355H|IFT122_ENST00000504021.1_Missense_Mutation_p.Y257H|IFT122_ENST00000440957.2_Missense_Mutation_p.Y154H|IFT122_ENST00000431818.2_Missense_Mutation_p.Y213H|IFT122_ENST00000348417.2_Missense_Mutation_p.Y363H|IFT122_ENST00000347300.2_Missense_Mutation_p.Y304H|IFT122_ENST00000349441.2_Missense_Mutation_p.Y252H	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	363					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						CAAGGACCGCTATGCCTACAG	0.547000													6	45					0	0	0.217242	0	0
KLF4	9314	broad.mit.edu	37	9	110249369	110249369	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:110249369C>A	ENST00000374672.4	-	4	1677	c.1204G>T	c.(1204-1206)Ggc>Tgc	p.G402C		NM_004235.4	NP_004226.3	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	436	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(5)|large_intestine(1)|lung(3)|pancreas(1)|prostate(2)	16						TTGCCGCAGCCCGCGTAATCA	0.597000													51	89					1.46357e-32	2.67466e-32	0.870114	1	0
JAKMIP2	9832	broad.mit.edu	37	5	147051255	147051255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:147051255G>A	ENST00000265272.5	-	2	582	c.115C>T	c.(115-117)Caa>Taa	p.Q39*	JAKMIP2_ENST00000507386.1_Nonsense_Mutation_p.Q39*|JAKMIP2_ENST00000333010.6_Intron	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	39						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTTCTCTTGATGCAGCTCT	0.557000													4	15					0	0	0.150653	0	0
AC008268.2	0	broad.mit.edu	37	2	96458294	96458294	+	RNA	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:96458294G>A	ENST00000471661.1	+	0	312																											CCAAGAGCTGGGTGAGTGATG	0.587000													3	25					0	0	0.150653	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590506	140590506	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:140590506C>T	ENST00000239450.2	+	1	2216	c.2027C>T	c.(2026-2028)gCg>gTg	p.A676V	PCDHB12_ENST00000541609.1_Missense_Mutation_p.A339V	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		676					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCCGGAGGCGGCCCCGGCC	0.687000													14	91					0	0	0.575678	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12884858	12884858	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:12884858C>A	ENST00000535591.1	-	4	1448	c.1253G>T	c.(1252-1254)tGc>tTc	p.C418F		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	418										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATGGTCAGGGCAGTTGTCAGT	0.478000													26	57					2.65835e-16	4.30432e-16	0.717897	1	0
GPC1	2817	broad.mit.edu	37	2	241404605	241404605	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:241404605T>G	ENST00000264039.2	+	7	1494	c.1246T>G	c.(1246-1248)Tgg>Ggg	p.W416G		NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	416					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		TGACCGCTGCTGGAACGGGAT	0.662000													3	10					0	0	0.115264	0	0
GRK6	2870	broad.mit.edu	37	5	176867988	176867988	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:176867988G>T	ENST00000355472.5	+	15	1779	c.1611G>T	c.(1609-1611)ctG>ctT	p.L537L	PRR7-AS1_ENST00000425316.3_RNA|GRK6_ENST00000528793.1_Silent_p.L537L|GRK6_ENST00000355958.5_Silent_p.L537L|GRK6_ENST00000393576.3_Silent_p.L503L	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	537					regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCAGACCTGGACTGGAAGG	0.602000													3	15					0.184627	0.188549	0.184627	1	0
ZSCAN4	201516	broad.mit.edu	37	19	58189929	58189929	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:58189929G>A	ENST00000318203.5	+	5	1655	c.958G>A	c.(958-960)Gtc>Atc	p.V320I		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	320					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGCCCCAAGGTCTTTAAGTA	0.438000													55	59					0	0	0.870114	0	0
IDO1	3620	broad.mit.edu	37	8	39782849	39782849	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:39782849G>T	ENST00000518237.1	+	9	1454	c.815G>T	c.(814-816)tGc>tTc	p.C272F	RP11-44K6.3_ENST00000517623.1_RNA|IDO1_ENST00000522495.1_Missense_Mutation_p.C272F	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	272					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	GTCTTTCAGTGCTTTGACGTC	0.488000													11	9					2.80697e-09	3.78911e-09	0.387290	1	0
BMPR2	659	broad.mit.edu	37	2	203329636	203329636	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:203329636T>A	ENST00000374580.4	+	2	720	c.181T>A	c.(181-183)Tcg>Acg	p.S61T	BMPR2_ENST00000479069.1_3'UTR|BMPR2_ENST00000374574.2_Missense_Mutation_p.S61T	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	61					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						AATATTATGCTCGAAAGGTAG	0.418000													24	97					0	0	0.681144	0	0
CCDC22	28952	broad.mit.edu	37	X	49093593	49093593	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:49093593A>T	ENST00000376227.3	+	2	261	c.91A>T	c.(91-93)Act>Tct	p.T31S	CCDC22_ENST00000496651.1_3'UTR	NM_014008.3	NP_054727.1	O60826	CCD22_HUMAN	coiled-coil domain containing 22	31										NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	18						CGCCTTCACCACTGAGCTGGT	0.612000													18	13					0	0	0.557998	0	0
C8orf74	203076	broad.mit.edu	37	8	10555351	10555351	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:10555351T>A	ENST00000304519.5	+	3	513	c.484T>A	c.(484-486)Tgg>Agg	p.W162R	RP1L1_ENST00000329335.3_Intron	NM_001040032.1	NP_001035121.1	Q6P047	CH074_HUMAN	chromosome 8 open reading frame 74	162										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	13				COAD - Colon adenocarcinoma(149;0.0811)		CAGGGACTTGTGGATCCACGA	0.682000													21	20					0	0	0.575678	0	0
KRT34	3885	broad.mit.edu	37	17	39538444	39538444	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:39538444G>A	ENST00000394001.1	-	1	211	c.181C>T	c.(181-183)Cgg>Tgg	p.R61W		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	61	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				ACGCAGGGCCGGGAGGAGCAG	0.627000													31	83					0	0	0.729181	0	0
SLFN5	162394	broad.mit.edu	37	17	33591385	33591385	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:33591385C>G	ENST00000299977.4	+	4	1470	c.1322C>G	c.(1321-1323)gCt>gGt	p.A441G	SLFN5_ENST00000542451.1_Intron	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	441					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		ATCTGTGATGCTCTTCTAATT	0.443000													30	76					0	0	0.740014	0	0
OR6B1	135946	broad.mit.edu	37	7	143701639	143701639	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:143701639G>T	ENST00000408922.2	+	1	618	c.550G>T	c.(550-552)Gta>Tta	p.V184L		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					CATCTCTCCAGTACTTAATCT	0.468000													31	47					1.75199e-13	2.6449e-13	0.717897	1	0
RNFT2	84900	broad.mit.edu	37	12	117191859	117191859	+	Silent	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:117191859A>C	ENST00000257575.4	+	5	854	c.621A>C	c.(619-621)tcA>tcC	p.S207S	RNFT2_ENST00000392549.2_Silent_p.S207S|RNFT2_ENST00000319176.7_Silent_p.S207S|RNFT2_ENST00000407967.3_Silent_p.S207S			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	207						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		AACAGGTCTCACTGAAGGTGA	0.557000													7	63					0	0	0.307466	0	0
TTN	7273	broad.mit.edu	37	2	179654843	179654843	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:179654843C>A	ENST00000589042.1	-	12	2025		c.e12-1		TTN_ENST00000360870.5_Splice_Site|TTN_ENST00000359218.5_Splice_Site|TTN_ENST00000460472.2_Splice_Site|TTN_ENST00000342175.6_Splice_Site|TTN_ENST00000342992.6_Splice_Site|TTN_ENST00000591111.1_Splice_Site	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTCATTATCTGATCATACA	0.308000													17	25					5.03518e-11	7.13603e-11	0.557998	1	0
MUC5B	727897	broad.mit.edu	37	11	1247853	1247853	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:1247853C>A	ENST00000447027.1	+	4	266	c.208C>A	c.(208-210)Ccg>Acg	p.P70T	MUC5B_ENST00000529681.1_Missense_Mutation_p.P70T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	70					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGCCCTGAACCCGGCGCACAA	0.647000													6	5					0.00116845	0.00127226	0.217242	1	0
TP53	7157	broad.mit.edu	37	17	7577157	7577157	+	Splice_Site	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:7577157T>A	ENST00000420246.2	-	8	915		c.e8-2		TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000455263.2_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(11)|p.0?(8)|p.E258fs*71(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATTACCACTACTCAGGATA	0.512000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			3	7					0	0	0.115264	0	0
FOXN4	121643	broad.mit.edu	37	12	109723225	109723225	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:109723225G>T	ENST00000299162.5	-	8	889	c.785C>A	c.(784-786)tCc>tAc	p.S262Y	FOXN4_ENST00000355216.1_Missense_Mutation_p.S82Y	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	262					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						GCCCTTGCGGGAGGAGCCGCT	0.602000													9	24					0.00448238	0.00481355	0.307466	1	0
OR2V2	285659	broad.mit.edu	37	5	180582280	180582280	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:180582280G>T	ENST00000328275.1	+	1	338	c.338G>T	c.(337-339)gGg>gTg	p.G113V		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGATCTGAGGGGCTCTTGCTG	0.517000													18	53					9.7654e-05	0.00011097	0.557998	1	0
SNAP29	9342	broad.mit.edu	37	22	21237785	21237785	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:21237785G>T	ENST00000215730.6	+	4	675	c.547G>T	c.(547-549)Gcc>Tcc	p.A183S		NM_004782.3	NP_004773.1	O95721	SNP29_HUMAN	synaptosomal-associated protein, 29kDa	183					cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|upper_aerodigestive_tract(1)	9	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			GGCTGGTTCTGCCATGAGTAC	0.498000													5	128					8.12818e-05	9.2534e-05	0.248553	1	0
ACACB	32	broad.mit.edu	37	12	109577566	109577566	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:109577566G>T	ENST00000338432.7	+	2	475	c.356G>T	c.(355-357)gGg>gTg	p.G119V	ACACB_ENST00000377854.5_Missense_Mutation_p.G119V|ACACB_ENST00000377848.3_Missense_Mutation_p.G119V			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	119					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CAAGCCAACGGGACTGGGACA	0.622000													52	105					2.74224e-37	5.11613e-37	0.870114	1	0
NF1	4763	broad.mit.edu	37	17	29541557	29541557	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:29541557T>A	ENST00000358273.4	+	13	1864	c.1481T>A	c.(1480-1482)tTg>tAg	p.L494*	NF1_ENST00000356175.3_Nonsense_Mutation_p.L494*|NF1_ENST00000431387.4_Nonsense_Mutation_p.L494*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	494					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(5)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TATCTTCTCTTGTCCATGGTG	0.303000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			22	35					0	0	0.592651	0	0
ZNF496	84838	broad.mit.edu	37	1	247492125	247492125	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:247492125C>A	ENST00000294753.4	-	4	898	c.434G>T	c.(433-435)aGc>aTc	p.S145I	ZNF496_ENST00000366498.2_Missense_Mutation_p.S145I	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	145					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GTCCAGAGGGCTGTCCCCATC	0.602000													21	131					2.21704e-12	3.29132e-12	0.639603	1	0
NEK6	10783	broad.mit.edu	37	9	127101941	127101941	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:127101941C>A	ENST00000373600.3	+	9	1031	c.816C>A	c.(814-816)taC>taA	p.Y272*	NEK6_ENST00000546191.1_Nonsense_Mutation_p.Y238*|NEK6_ENST00000320246.5_Nonsense_Mutation_p.Y238*|NEK6_ENST00000373603.1_Nonsense_Mutation_p.Y238*|NEK6_ENST00000545174.1_Nonsense_Mutation_p.Y238*|NEK6_ENST00000540326.1_Nonsense_Mutation_p.Y256*|NEK6_ENST00000394199.2_Nonsense_Mutation_p.Y272*|NEK6_ENST00000539416.1_Nonsense_Mutation_p.Y263*	NM_001145001.2	NP_001138473.1	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6	238	Protein kinase.				apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15						GTCTGCTGTACGAGGTGAGTC	0.587000													13	34					2.27111e-07	2.89092e-07	0.411799	1	0
OR6C76	390326	broad.mit.edu	37	12	55820361	55820361	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:55820361G>T	ENST00000328314.3	+	1	324	c.324G>T	c.(322-324)gaG>gaT	p.E108D		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCTCAACGGAGTTTTTCCTCC	0.403000													53	126					7.77372e-23	1.35336e-22	0.870114	1	0
C1QB	713	broad.mit.edu	37	1	22987407	22987407	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:22987407C>T	ENST00000509305.1	+	3	630	c.284C>T	c.(283-285)cCt>cTt	p.P95L	C1QB_ENST00000314933.6_Missense_Mutation_p.P97L			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	97	Collagen-like 2.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCCATGGGCCCTAAAGGTGGC	0.617000													4	55					0	0	0.150653	0	0
HK1	3098	broad.mit.edu	37	10	71103608	71103608	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:71103608G>A	ENST00000448642.2	+	7	583	c.194G>A	c.(193-195)cGg>cAg	p.R65Q	HK1_ENST00000494253.1_3'UTR|HK1_ENST00000298649.3_Missense_Mutation_p.R29Q|HK1_ENST00000360289.2_Missense_Mutation_p.R18Q|HK1_ENST00000359426.6_Missense_Mutation_p.R30Q|HK1_ENST00000404387.2_Missense_Mutation_p.R34Q			P19367	HXK1_HUMAN	hexokinase 1	30	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						TATGCCATGCGGCTCTCCGAT	0.532000													38	93					0	0	0.870114	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774465	140774465	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:140774465G>T	ENST00000398604.2	+	1	2085	c.2085G>T	c.(2083-2085)gtG>gtT	p.V695V	PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTCGTGGTGGCAGTGGCTG	0.607000													6	12					0.00116845	0.00127226	0.217242	1	0
IGHV3-13	28449	broad.mit.edu	37	14	106586240	106586240	+	RNA	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:106586240A>T	ENST00000390602.2	-	0	324																											TCGGCCCTTCACGGAGCCTGG	0.517000													34	68					0	0	0.750413	0	0
CACNG7	59284	broad.mit.edu	37	19	54418655	54418655	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:54418655G>T	ENST00000391767.1	+	4	532	c.320G>T	c.(319-321)aGc>aTc	p.S107I	CACNG7_ENST00000222212.2_Missense_Mutation_p.S107I|CACNG7_ENST00000391766.1_Missense_Mutation_p.S107I|CACNG7_ENST00000468076.1_3'UTR			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	107					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CCCATGGTCAGCCTCTTCCTC	0.597000													11	27					2.61681e-11	3.76845e-11	0.457914	1	0
ACR	49	broad.mit.edu	37	22	51183253	51183253	+	Missense_Mutation	SNP	G	G	T	rs140584689		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:51183253G>T	ENST00000216139.5	+	5	924	c.884G>T	c.(883-885)cGt>cTt	p.R295L	ACR_ENST00000527761.1_3'UTR	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	295					acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		AACGCTTTGCGTATGATTCAA	0.602000													4	13					0.000602214	0.000664989	0.184627	1	0
KCNA5	3741	broad.mit.edu	37	12	5154247	5154247	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:5154247G>A	ENST00000252321.3	+	1	1163	c.934G>A	c.(934-936)Gtg>Atg	p.V312M		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	312						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TGGCCCTACGGTGGCACCGCT	0.716000													17	50					0	0	0.539581	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409716	59409716	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:59409716C>A	ENST00000301645.3	-	3	492	c.355G>T	c.(355-357)Gga>Tga	p.G119*		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	119					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GTGGTATTTCCATCCATCGGG	0.413000									Neonatal Giant Cell Hepatitis				64	25					1.65906e-26	2.97963e-26	0.870114	1	0
COL4A2	1284	broad.mit.edu	37	13	111155585	111155585	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:111155585G>T	ENST00000360467.5	+	42	4301	c.3995G>T	c.(3994-3996)gGg>gTg	p.G1332V	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1332	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGGGACTCCGGGCCCCAGGGC	0.647000													4	35					0.00909568	0.00958651	0.150653	1	0
NOL4	8715	broad.mit.edu	37	18	31803030	31803030	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:31803030T>A	ENST00000261592.5	-	1	485	c.188A>T	c.(187-189)cAg>cTg	p.Q63L	NOL4_ENST00000589544.1_Missense_Mutation_p.Q63L|RP11-379L18.1_ENST00000587528.1_RNA|NOL4_ENST00000269185.4_5'UTR	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	63						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						CTGGCCCAGCTGGAAGCCCTT	0.587000													17	18					0	0	0.520397	0	0
EVC2	132884	broad.mit.edu	37	4	5564793	5564793	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:5564793C>G	ENST00000310917.2	-	22	4200	c.3469G>C	c.(3469-3471)Gga>Cga	p.G1157R	EVC2_ENST00000344408.5_Missense_Mutation_p.G1237R|EVC2_ENST00000344938.1_Intron	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1237						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CTTCCTTTTCCAGAGAATATC	0.428000													38	80					0	0	0.804634	0	0
RGS22	26166	broad.mit.edu	37	8	100990221	100990221	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:100990221C>T	ENST00000360863.6	-	23	3637	c.3443G>A	c.(3442-3444)aGt>aAt	p.S1148N	RGS22_ENST00000523287.1_Missense_Mutation_p.S967N|RGS22_ENST00000523437.1_Missense_Mutation_p.S1136N	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1148					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CTCTAAAACACTCATAATATT	0.323000													5	92					0	0	0.184627	0	0
RXFP3	51289	broad.mit.edu	37	5	33937183	33937183	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:33937183G>A	ENST00000330120.3	+	1	693	c.338G>A	c.(337-339)cGc>cAc	p.R113H		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	113						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						CAGGGCTGGCGCAAGTCCTCT	0.592000													21	37					0	0	0.575678	0	0
BDP1	55814	broad.mit.edu	37	5	70805306	70805306	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:70805306A>G	ENST00000358731.4	+	17	2650	c.2387A>G	c.(2386-2388)aAt>aGt	p.N796S	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	796					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CAAGAGAATAATAAGGCAAAT	0.373000													18	48					0	0	0.575678	0	0
KRT13	3860	broad.mit.edu	37	17	39661352	39661352	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:39661352C>A	ENST00000246635.3	-	1	497	c.451G>T	c.(451-453)Gac>Tac	p.D151Y	KRT13_ENST00000587544.1_Missense_Mutation_p.D151Y|KRT13_ENST00000336861.3_Missense_Mutation_p.D151Y	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	151	Linker 1.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				GGGCTGTAGTCCCGCTCAGGG	0.622000													34	42					3.90053e-15	6.14063e-15	0.760397	1	0
CDH20	28316	broad.mit.edu	37	18	59157924	59157924	+	Silent	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:59157924C>G	ENST00000262717.4	+	2	536	c.138C>G	c.(136-138)ctC>ctG	p.L46L	CDH20_ENST00000536675.2_Silent_p.L46L|CDH20_ENST00000538374.1_Silent_p.L46L			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	46					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TAGAAGCACTCCTGTCAGACA	0.532000													14	28					0	0	0.457914	0	0
TRIM67	440730	broad.mit.edu	37	1	231339744	231339744	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:231339744G>T	ENST00000444294.3	+	6	2518	c.1660G>T	c.(1660-1662)Ggg>Tgg	p.G554W	TRIM67_ENST00000449018.3_Missense_Mutation_p.G494W|TRIM67_ENST00000366652.2_Missense_Mutation_p.G556W|TRIM67_ENST00000366653.5_Missense_Mutation_p.G556W	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	556	Fibronectin type-III.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CGACGGTGCCGGGGGACAGTT	0.632000													8	38					3.09899e-07	3.93672e-07	0.307466	1	0
WDYHV1	55093	broad.mit.edu	37	8	124448762	124448762	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:124448762T>G	ENST00000523984.1	+	4	352	c.124T>G	c.(124-126)Ttg>Gtg	p.L42V	WDYHV1_ENST00000523356.1_Missense_Mutation_p.L102V|WDYHV1_ENST00000518125.1_Intron|WDYHV1_ENST00000287387.2_Missense_Mutation_p.L102V|WDYHV1_ENST00000517609.1_3'UTR			Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	102					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(3)	17						CGATACTGTCTTGCCATTTCC	0.393000													4	73					0	0	0.217242	0	0
GABRA3	2556	broad.mit.edu	37	X	151366210	151366210	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:151366210C>T	ENST00000370314.4	-	8	1064	c.826G>A	c.(826-828)Ggc>Agc	p.G276S	GABRA3_ENST00000535043.1_Missense_Mutation_p.G276S|GABRA3_ENST00000370311.1_Missense_Mutation_p.G276S	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	276					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACAAAGTAGCCAATTTTTCGC	0.423000													12	34					0	0	0.411799	0	0
PPP1CB	5500	broad.mit.edu	37	2	29006809	29006809	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:29006809G>A	ENST00000395366.2	+	5	829	c.557G>A	c.(556-558)cGg>cAg	p.R186Q	PPP1CB_ENST00000358506.2_Missense_Mutation_p.R186Q|SPDYA_ENST00000462832.1_3'UTR|PPP1CB_ENST00000296122.6_Missense_Mutation_p.R186Q	NM_002709.2	NP_002700.1	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta isozyme	186					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			cervix(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					GAGCAGATTCGGAGAATTATG	0.328000													22	66					0	0	0.639603	0	0
MUC3A	4584	broad.mit.edu	37	7	100552963	100552963	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:100552963G>A	ENST00000319509.7	+	2	1608	c.1608G>A	c.(1606-1608)caG>caA	p.Q536Q						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GTCAGCTCCAGACCAGATGCC	0.562000													10	74					0	0	0.361761	0	0
PTCHD2	57540	broad.mit.edu	37	1	11577528	11577528	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:11577528C>A	ENST00000294484.6	+	7	1896	c.1758C>A	c.(1756-1758)gcC>gcA	p.A586A	PTCHD2_ENST00000389575.3_Silent_p.A586A	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	586	SSD.				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AGATCCCAGCCGTCCACGACT	0.617000													41	64					1.5731e-28	2.84982e-28	0.859065	1	0
HK1	3098	broad.mit.edu	37	10	71129011	71129011	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:71129011G>A	ENST00000448642.2	+	11	1104	c.715G>A	c.(715-717)Gta>Ata	p.V239I	HK1_ENST00000494253.1_3'UTR|HK1_ENST00000298649.3_Missense_Mutation_p.V203I|HK1_ENST00000360289.2_Missense_Mutation_p.V192I|HK1_ENST00000359426.6_Missense_Mutation_p.V204I|HK1_ENST00000404387.2_Missense_Mutation_p.V208I			P19367	HXK1_HUMAN	hexokinase 1	204	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						TGCCAACATCGTAGCTGTGGT	0.527000													8	36					0	0	0.307466	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907362	12907362	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:12907362C>A	ENST00000317869.6	-	2	1006	c.781G>T	c.(781-783)Gat>Tat	p.D261Y		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TCCCCCTGATCTTCATTAACA	0.502000													7	88					5.18039e-06	6.19072e-06	0.278610	1	0
TNR	7143	broad.mit.edu	37	1	175362963	175362963	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:175362963G>T	ENST00000367674.1	-	6	2017	c.1309C>A	c.(1309-1311)Ccc>Acc	p.P437T	TNR_ENST00000263525.2_Missense_Mutation_p.P437T	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	437	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					AATGAGAAGGGCTCCCACTGC	0.458000													41	88					1.7489e-18	2.93835e-18	0.859065	1	0
USH1C	10083	broad.mit.edu	37	11	17542423	17542423	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:17542423G>T	ENST00000005226.7	-	14	1203	c.1204C>A	c.(1204-1206)Cca>Aca	p.P402T	USH1C_ENST00000527720.1_Missense_Mutation_p.P371T|USH1C_ENST00000318024.4_Missense_Mutation_p.P402T|USH1C_ENST00000527020.1_Missense_Mutation_p.P383T	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	402					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						TTACACTTTGGCTTGCGAAGG	0.522000													127	76					6.55312e-83	1.24869e-82	0.870114	1	0
OR5K3	403277	broad.mit.edu	37	3	98109954	98109954	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:98109954T>C	ENST00000383695.1	+	1	445	c.445T>C	c.(445-447)Tac>Cac	p.Y149H	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005516.1	NP_001005516.1	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K, member 3	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|prostate(1)|skin(1)|urinary_tract(1)	27						TGCAGGAGCCTACCTAGCTGG	0.468000													20	95					0	0	0.592651	0	0
SNHG24	101929369	broad.mit.edu	37	14	101450211	101450211	+	RNA	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:101450211C>A	ENST00000554693.2	+	0	799																											GAAGACCAATCCTGGATCGAT	0.373000													38	103					7.53189e-24	1.32231e-23	0.834066	1	0
ITGAX	3687	broad.mit.edu	37	16	31368412	31368412	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:31368412C>A	ENST00000268296.4	+	4	429	c.308C>A	c.(307-309)tCc>tAc	p.S103Y	ITGAX_ENST00000562522.1_Missense_Mutation_p.S103Y|ITGAX_ENST00000562918.1_3'UTR	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	103					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						ACCAGCCCTTCCCAGCTGCTG	0.677000													7	24					0.0381472	0.039803	0.278610	1	0
PCDHA9	9752	broad.mit.edu	37	5	140229863	140229863	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:140229863C>T	ENST00000378122.3	+	1	2507	c.1783C>T	c.(1783-1785)Cgc>Tgc	p.R595C	PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.R595C	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGAAGGTGCGCGCAGTGGA	0.687000													5	41					0	0	0.184627	0	0
RAB3IL1	5866	broad.mit.edu	37	11	61666786	61666786	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:61666786C>A	ENST00000394836.2	-	9	1223	c.1066_splice	c.e9+1	p.A356_splice	RAB3IL1_ENST00000301773.5_Splice_Site_p.A330_splice	NM_013401.2	NP_037533.2	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	356							protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(4)|skin(3)|urinary_tract(1)	14						GGGCGCTCACCGTCCTGCCGC	0.657000											OREG0021017	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	12					1.12685e-05	1.33135e-05	0.307466	1	0
CEP120	153241	broad.mit.edu	37	5	122734946	122734946	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:122734946C>A	ENST00000306467.5	-	5	800	c.496G>T	c.(496-498)Gac>Tac	p.D166Y	CEP120_ENST00000328236.5_Missense_Mutation_p.D166Y|CEP120_ENST00000306481.6_Missense_Mutation_p.D140Y|CEP120_ENST00000395431.2_Missense_Mutation_p.D166Y			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	166						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						GCCACAATGTCCCTGGGGTCA	0.413000													9	30					0.00621372	0.0065935	0.335167	1	0
PCOLCE2	26577	broad.mit.edu	37	3	142561780	142561780	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:142561780C>A	ENST00000295992.3	-	4	865	c.559G>T	c.(559-561)Gcc>Tcc	p.A187S	PCOLCE2_ENST00000485766.1_Missense_Mutation_p.A187S	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	187	CUB 2.					extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						TTCTTTGGGGCTACAATGTGC	0.532000													29	24					1.74807e-11	2.52903e-11	0.750413	1	0
ZSWIM5	57643	broad.mit.edu	37	1	45484449	45484449	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:45484449G>T	ENST00000359600.5	-	14	3440	c.3235C>A	c.(3235-3237)Cga>Aga	p.R1079R		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	1079							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					GTGCAGCGTCGTAAGATGTCT	0.582000											OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	20					4.74835e-14	7.27383e-14	0.750413	1	0
TMTC1	83857	broad.mit.edu	37	12	29904705	29904705	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:29904705G>T	ENST00000256062.5	-	5	981	c.508C>A	c.(508-510)Cgg>Agg	p.R170R	TMTC1_ENST00000539277.1_Silent_p.R278R|TMTC1_ENST00000552618.1_Silent_p.R278R|TMTC1_ENST00000551659.1_Silent_p.R278R|TMTC1_ENST00000381224.2_Silent_p.R170R	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	278						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TGAGGGAACCGCTGCTGCTTC	0.647000													13	16					7.03913e-09	9.42067e-09	0.411799	1	0
HNRNPR	10236	broad.mit.edu	37	1	23648084	23648084	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:23648084C>G	ENST00000478691.1	-	6	716	c.445G>C	c.(445-447)Gtt>Ctt	p.V149L	HNRNPR_ENST00000426846.2_Missense_Mutation_p.V90L|HNRNPR_ENST00000606561.1_Missense_Mutation_p.V111L|HNRNPR_ENST00000374612.1_Missense_Mutation_p.V250L|HNRNPR_ENST00000374616.3_Missense_Mutation_p.V250L|HNRNPR_ENST00000302271.6_Missense_Mutation_p.V250L|HNRNPR_ENST00000427764.2_Missense_Mutation_p.V212L	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	250	Asp/Glu-rich (acidic).					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		ATGGATCCAACAAAAAGTCTG	0.368000													4	87					0	0	0.184627	0	0
PIK3R4	30849	broad.mit.edu	37	3	130452432	130452432	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:130452432T>A	ENST00000356763.3	-	4	1967	c.1410A>T	c.(1408-1410)ttA>ttT	p.L470F		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	470					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						CATCTTGGGCTAAGTGGGCTA	0.383000													8	64					0	0	0.307466	0	0
RYR1	6261	broad.mit.edu	37	19	38976684	38976684	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:38976684C>A	ENST00000355481.4	+	34	5520	c.5389C>A	c.(5389-5391)Cgc>Agc	p.R1797S	RYR1_ENST00000359596.3_Missense_Mutation_p.R1797S|RYR1_ENST00000360985.3_Missense_Mutation_p.R1797S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1797	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCCCCGGCCCGCCTCAGCCC	0.716000													32	18					1.61788e-16	2.63327e-16	0.760397	1	0
TRIM14	9830	broad.mit.edu	37	9	100881382	100881382	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:100881382C>A	ENST00000341469.2	-	1	98	c.89G>T	c.(88-90)cGc>cTc	p.R30L	TRIM14_ENST00000375098.3_Missense_Mutation_p.R30L|TRIM14_ENST00000342043.3_Missense_Mutation_p.R30L	NM_014788.2	NP_055603.2	Q14142	TRI14_HUMAN	tripartite motif containing 14	30						cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(62;0.0559)				CTCAGCCACGCGGTCGCCATG	0.741000													9	8					1.58986e-06	1.92945e-06	0.361761	1	0
NRIP1	8204	broad.mit.edu	37	21	16339770	16339770	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr21:16339770T>A	ENST00000400202.1	-	3	1456	c.744A>T	c.(742-744)gaA>gaT	p.E248D	NRIP1_ENST00000318948.4_Missense_Mutation_p.E248D|NRIP1_ENST00000400199.1_Missense_Mutation_p.E248D			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	248	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TAGCCCTTTTTTCCACCATGC	0.473000													17	89					0	0	0.557998	0	0
ARID1A	8289	broad.mit.edu	37	1	27099370	27099370	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:27099370A>T	ENST00000324856.7	+	14	3978	c.3607A>T	c.(3607-3609)Aat>Tat	p.N1203Y	ARID1A_ENST00000457599.2_Missense_Mutation_p.N1203Y|ARID1A_ENST00000374152.2_Missense_Mutation_p.N820Y	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1203					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCAGAAGCGGAATTCCATGAC	0.473000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								7	45					0	0	0.278610	0	0
MCHR1	2847	broad.mit.edu	37	22	41077234	41077234	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:41077234A>G	ENST00000249016.4	+	2	1267	c.571A>G	c.(571-573)Atg>Gtg	p.M191V	MCHR1_ENST00000381433.2_Intron|MCHR1_ENST00000498400.1_3'UTR	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	191					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						CATCACGGCCATGGATGCCAA	0.572000													18	59					0	0	0.557998	0	0
FOXL2	668	broad.mit.edu	37	3	138664549	138664549	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:138664549C>G	ENST00000330315.3	-	1	1433	c.1016G>C	c.(1015-1017)aGt>aCt	p.S339T		NM_023067.3	NP_075555.1	P58012	FOXL2_HUMAN	forkhead box L2	339					convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			large_intestine(1)|lung(1)|ovary(333)|skin(1)	336						GCCCGGCGCACTGGTGggcgc	0.766000			Mis		granulosa-cell tumour of the ovary		"""Blepharophimosis, ptosis and epicanthus inversus Types I, II; Premature ovarian failure type III"""						3	15					0	0	0.115264	0	0
DMD	1756	broad.mit.edu	37	X	32717329	32717329	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:32717329C>T	ENST00000357033.4	-	8	937	c.731G>A	c.(730-732)aGc>aAc	p.S244N	DMD_ENST00000378677.2_Missense_Mutation_p.S240N|DMD_ENST00000288447.4_Missense_Mutation_p.S236N	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	244					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGCTTCAATGCTCACTTGTTG	0.393000													33	36					0	0	0.788014	0	0
PCDH12	51294	broad.mit.edu	37	5	141336067	141336067	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:141336067G>T	ENST00000231484.3	-	1	2560	c.1350C>A	c.(1348-1350)atC>atA	p.I450I		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	450	Cadherin 4.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATGTCACTGATCTGAATGC	0.488000													30	73					1.80694e-10	2.50964e-10	0.740014	1	0
POTEM	641455	broad.mit.edu	37	14	20019956	20019956	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:20019956A>G	ENST00000551509.1	-	1	316	c.265T>C	c.(265-267)Tct>Cct	p.S89P		NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	89										endometrium(4)|kidney(1)|lung(4)	9						TTCATAGCAGAGTCGTCGTGG	0.627000													8	279					0	0	0.435327	0	0
ADH1A	124	broad.mit.edu	37	4	100205673	100205673	+	Nonsense_Mutation	SNP	G	G	T	rs143808002		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:100205673G>T	ENST00000209668.2	-	5	563	c.450C>A	c.(448-450)taC>taA	p.Y150*	RP11-696N14.1_ENST00000500358.2_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	150					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CCACCACTGTGTACTGTGAGA	0.517000													15	23					1.05317e-09	1.43406e-09	0.457914	1	0
SLX4	84464	broad.mit.edu	37	16	3642820	3642820	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:3642820T>A	ENST00000294008.3	-	11	2847	c.2207A>T	c.(2206-2208)cAg>cTg	p.Q736L		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	736	BTB.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CAGGACACGCTGGGTCAGAAC	0.567000								Direct reversal of damage					7	17					0	0	0.278610	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104512136	104512136	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:104512136A>C	ENST00000372582.1	+	5	1365	c.609A>C	c.(607-609)gaA>gaC	p.E203D	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E203D	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	203	Ig-like C2-type 2.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGATCCAAGAAGTTCAAGAAG	0.333000													4	48					0	0	0.184627	0	0
KLHL1	57626	broad.mit.edu	37	13	70681587	70681587	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:70681587G>C	ENST00000377844.4	-	1	1004	c.245C>G	c.(244-246)cCg>cGg	p.P82R	ATXN8OS_ENST00000414504.2_RNA|KLHL1_ENST00000545028.1_5'UTR	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	82	Ser-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		ggaagaggacggggaggacga	0.597000													7	41					0	0	0.278610	0	0
PLCB1	23236	broad.mit.edu	37	20	8862413	8862413	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:8862413C>A	ENST00000338037.6	+	32	3595	c.3568C>A	c.(3568-3570)Cct>Act	p.P1190T	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1190					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						GTCCTCAGACCCTGGAAAAGT	0.522000													36	142					4.32679e-17	7.09776e-17	0.827153	1	0
ERBB4	2066	broad.mit.edu	37	2	212589910	212589910	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:212589910G>A	ENST00000342788.4	-	6	942	c.632C>T	c.(631-633)aCg>aTg	p.T211M	ERBB4_ENST00000402597.1_Missense_Mutation_p.T211M|ERBB4_ENST00000484474.1_5'UTR|ERBB4_ENST00000436443.1_Missense_Mutation_p.T211M	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	211	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TGCACACACCGTCCTTGTCAC	0.512000										TSP Lung(8;0.080)			10	61					0	0	0.387290	0	0
MTMR12	54545	broad.mit.edu	37	5	32233968	32233968	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:32233968C>T	ENST00000382142.3	-	15	1755	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	MTMR12_ENST00000264934.5_Intron|MTMR12_ENST00000280285.5_Intron|MTMR12_ENST00000510216.1_5'UTR	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	529	Interaction with MTM1.|Myotubularin phosphatase.					cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GCTTTGGGTTCAAACTGCACC	0.483000													8	71					0	0	0.307466	0	0
EMB	133418	broad.mit.edu	37	5	49707098	49707098	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:49707098C>A	ENST00000303221.5	-	3	531	c.316G>T	c.(316-318)Gat>Tat	p.D106Y	EMB_ENST00000506190.1_5'UTR|EMB_ENST00000508934.1_Intron|EMB_ENST00000514111.1_Missense_Mutation_p.D56Y	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	106	Ig-like V-type 1.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TGTTCACCATCTTTTTTCCAA	0.363000													23	57					2.21704e-12	3.29132e-12	0.639603	1	0
SLC6A11	6538	broad.mit.edu	37	3	10885978	10885978	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:10885978G>T	ENST00000254488.2	+	5	769	c.703G>T	c.(703-705)Gcc>Tcc	p.A235S		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	235					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCTCTTGGCAGCCTGGACCAT	0.582000													3	36					0.00909568	0.00958651	0.150653	1	0
HSPG2	3339	broad.mit.edu	37	1	22165395	22165395	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:22165395T>A	ENST00000374695.3	-	74	10152	c.10073A>T	c.(10072-10074)gAg>gTg	p.E3358V		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3358	Ig-like C2-type 19.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCCTGAGTCCTCAGGGGCTGC	0.677000													8	9					0	0	0.278610	0	0
HK1	3098	broad.mit.edu	37	10	71103609	71103609	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:71103609G>T	ENST00000448642.2	+	7	584	c.195G>T	c.(193-195)cgG>cgT	p.R65R	HK1_ENST00000494253.1_3'UTR|HK1_ENST00000298649.3_Silent_p.R29R|HK1_ENST00000360289.2_Silent_p.R18R|HK1_ENST00000359426.6_Silent_p.R30R|HK1_ENST00000404387.2_Silent_p.R34R			P19367	HXK1_HUMAN	hexokinase 1	30	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						ATGCCATGCGGCTCTCCGATG	0.527000													35	92					5.80444e-35	1.07014e-34	0.870114	1	0
LRRCC1	85444	broad.mit.edu	37	8	86035652	86035652	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:86035652C>G	ENST00000414626.2	+	6	1764	c.875C>G	c.(874-876)tCt>tGt	p.S292C	LRRCC1_ENST00000360375.3_Missense_Mutation_p.S312C			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	312					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						TTTTAGACTTCTAATTCAATA	0.269000													11	83					0	0	0.411799	0	0
CHL1	10752	broad.mit.edu	37	3	423918	423918	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:423918C>A	ENST00000256509.2	+	17	2575	c.1933C>A	c.(1933-1935)Cgg>Agg	p.R645R	CHL1-AS1_ENST00000417612.1_RNA|CHL1_ENST00000397491.2_Silent_p.R629R	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	629	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAGGAGTGTTCGGCTGACCTG	0.403000													11	71					9.31168e-06	1.10223e-05	0.435327	1	0
ITK	3702	broad.mit.edu	37	5	156675975	156675975	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:156675975C>A	ENST00000422843.3	+	16	1901	c.1749C>A	c.(1747-1749)gcC>gcA	p.A583A	ITK_ENST00000519749.1_3'UTR	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	583	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCCGGCTGGCCTCCACACACG	0.498000			T	SYK	peripheral T-cell lymphoma								9	36					9.70103e-10	1.32383e-09	0.361761	1	0
INHBC	3626	broad.mit.edu	37	12	57843083	57843083	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:57843083C>A	ENST00000309668.2	+	2	464	c.337C>A	c.(337-339)Cgt>Agt	p.R113S	INHBC_ENST00000550133.1_Missense_Mutation_p.R113S	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	113					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						CAACCAGACTCGTCTTGATTT	0.498000													69	187					1.42382e-21	2.45825e-21	0.870114	1	0
FMR1	2332	broad.mit.edu	37	X	147009854	147009854	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:147009854A>T	ENST00000218200.8	+	4	442	c.213A>T	c.(211-213)gcA>gcT	p.A71A	FMR1_ENST00000370471.3_Silent_p.A71A|FMR1_ENST00000370470.1_Silent_p.A71A|FMR1_ENST00000439526.2_Silent_p.A71A|FMR1_ENST00000334557.6_Silent_p.A71A|FMR1_ENST00000370477.1_Silent_p.A71A|FMR1_ENST00000370475.4_Silent_p.A71A	NM_001185076.1|NM_001185082.1	NP_001172005.1|NP_001172011.1	Q06787	FMR1_HUMAN	fragile X mental retardation 1	71					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			NS(1)|breast(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	35	Acute lymphoblastic leukemia(192;6.56e-05)					ATTCCAGAGCAAATGAAAAAG	0.308000									Fragile X syndrome				39	76					0	0	0.834066	0	0
PCBP1	5093	broad.mit.edu	37	2	70314938	70314938	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:70314938C>G	ENST00000303577.5	+	1	354	c.63C>G	c.(61-63)caC>caG	p.H21Q	PCBP1-AS1_ENST00000452431.1_RNA|PCBP1-AS1_ENST00000596028.1_RNA|PCBP1-AS1_ENST00000423402.1_RNA|PCBP1-AS1_ENST00000413436.1_RNA	NM_006196.3	NP_006187.2	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	21	KH 1.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|skin(1)	12						TTCTTATGCACGGAAAGGAAG	0.572000													43	97					0	0	0.853193	0	0
FFAR1	2864	broad.mit.edu	37	19	35842828	35842828	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:35842828G>A	ENST00000246553.2	+	1	384	c.374G>A	c.(373-375)gGg>gAg	p.G125E		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	125					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	TATTCCTGGGGGGTGTGCGCG	0.687000													7	47					0	0	0.335167	0	0
PCDH15	65217	broad.mit.edu	37	10	55698613	55698613	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:55698613A>C	ENST00000373965.2	-	26	3750	c.3356T>G	c.(3355-3357)cTg>cGg	p.L1119R	PCDH15_ENST00000395438.1_Missense_Mutation_p.L1112R|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395430.1_Missense_Mutation_p.L1112R|PCDH15_ENST00000320301.6_Missense_Mutation_p.L1112R|PCDH15_ENST00000395433.1_Missense_Mutation_p.L1090R|PCDH15_ENST00000395432.2_Missense_Mutation_p.L1075R|PCDH15_ENST00000409834.1_Missense_Mutation_p.L723R|PCDH15_ENST00000437009.1_Missense_Mutation_p.L1041R|PCDH15_ENST00000361849.3_Missense_Mutation_p.L1112R|PCDH15_ENST00000414778.1_Missense_Mutation_p.L1117R|PCDH15_ENST00000395445.1_Missense_Mutation_p.L1119R|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000373957.3_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1112	Cadherin 10.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GACCACTTCCAGGGAATCAGC	0.378000										HNSCC(58;0.16)			28	66					0	0	0.717897	0	0
C11orf82	220042	broad.mit.edu	37	11	82643096	82643096	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:82643096G>T	ENST00000533655.1	+	6	928	c.716G>T	c.(715-717)tGg>tTg	p.W239L	C11orf82_ENST00000528759.1_3'UTR|C11orf82_ENST00000525388.1_3'UTR|C11orf82_ENST00000329143.3_5'UTR|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000430323.2_Missense_Mutation_p.W239L	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	239					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TCAAAATTCTGGCAGCCATCA	0.378000													10	78					7.48243e-07	9.26043e-07	0.335167	1	0
NUP214	8021	broad.mit.edu	37	9	134073958	134073958	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:134073958A>C	ENST00000359428.5	+	29	5221	c.5077A>C	c.(5077-5079)Aca>Cca	p.T1693P	NUP214_ENST00000483497.2_Missense_Mutation_p.T519P|NUP214_ENST00000411637.2_Missense_Mutation_p.T1683P|NUP214_ENST00000451030.1_Missense_Mutation_p.T1694P			P35658	NU214_HUMAN	nucleoporin 214kDa	1693	11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.|Pro/Ser/Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GACTGGTAGCACAGCCAGCAC	0.607000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								11	39					0	0	0.361761	0	0
ZEB2	9839	broad.mit.edu	37	2	145156129	145156129	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:145156129C>A	ENST00000558170.2	-	8	3809	c.2625G>T	c.(2623-2625)ctG>ctT	p.L875L	ZEB2_ENST00000303660.4_Silent_p.L875L|ZEB2_ENST00000539609.3_Silent_p.L851L|ZEB2_ENST00000409487.3_Silent_p.L875L	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	875						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TTTTGTTGTCCAGATTATTTG	0.393000													48	72					3.05275e-18	5.11519e-18	0.864702	1	0
KCNA5	3741	broad.mit.edu	37	12	5155089	5155089	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:5155089C>T	ENST00000252321.3	+	1	2005	c.1776C>T	c.(1774-1776)agC>agT	p.S592S		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	592						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						AGGCCAAGAGCAACGTGGACT	0.587000													7	27					0	0	0.248553	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086536	39086536	+	Silent	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr21:39086536T>C	ENST00000400482.3	-	3	1513	c.924A>G	c.(922-924)ctA>ctG	p.L308L	KCNJ6_ENST00000288309.6_Silent_p.L308L	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	308					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CCATTCCTTCTAGGATGACCA	0.453000													27	68					0	0	0.729181	0	0
ADSSL1	122622	broad.mit.edu	37	14	105208227	105208227	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:105208227G>T	ENST00000332972.5	+	9	1124	c.965G>T	c.(964-966)gGt>gTt	p.G322V	ADSSL1_ENST00000330877.2_Missense_Mutation_p.G279V	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	279					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	ACCGTGGGCGGTGTGTGCACG	0.602000													36	50					1.62957e-23	2.85289e-23	0.840704	1	0
JAKMIP1	152789	broad.mit.edu	37	4	6066717	6066717	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:6066717A>C	ENST00000409021.3	-	9	1770	c.1321T>G	c.(1321-1323)Ttt>Gtt	p.F441V	JAKMIP1_ENST00000282924.5_Missense_Mutation_p.F441V|JAKMIP1_ENST00000410077.2_Missense_Mutation_p.F276V|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.F256V|JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.F441V	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	441	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AATCCAAAAAATGTCTCCACA	0.493000													4	44					0	0	0.150653	0	0
XIRP2	129446	broad.mit.edu	37	2	168105385	168105385	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:168105385G>T	ENST00000409195.1	+	9	7572	c.7483G>T	c.(7483-7485)Gac>Tac	p.D2495Y	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D2495Y|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.D2273Y|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2320					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATTATCTATTGACTCTGCAAA	0.398000													29	49					7.41945e-09	9.90846e-09	0.693898	1	0
DMXL1	1657	broad.mit.edu	37	5	118485175	118485175	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:118485175C>T	ENST00000311085.8	+	18	3733	c.3653C>T	c.(3652-3654)tCt>tTt	p.S1218F	DMXL1_ENST00000539542.1_Missense_Mutation_p.S1218F	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1218								p.S1218Y(1)|p.S1218C(1)		breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTTCCTGTTTCTTTATCGTGG	0.443000													26	110					0	0	0.693898	0	0
KIF15	56992	broad.mit.edu	37	3	44867569	44867569	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:44867569T>C	ENST00000326047.4	+	21	2737	c.2588T>C	c.(2587-2589)cTa>cCa	p.L863P	KIF15_ENST00000425755.1_Missense_Mutation_p.L498P	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	863					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AAAGCCTGCCTACAGGATTCC	0.294000													30	27					0	0	0.750413	0	0
KIAA1217	56243	broad.mit.edu	37	10	24508697	24508697	+	Silent	SNP	G	G	T	rs141733021		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:24508697G>T	ENST00000376454.3	+	2	243	c.213G>T	c.(211-213)ggG>ggT	p.G71G	KIAA1217_ENST00000458595.1_Silent_p.G71G|KIAA1217_ENST00000376462.1_5'UTR|KIAA1217_ENST00000376452.3_Silent_p.G71G	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	71					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CCCTAGGGGGGCCCCGAAGTT	0.512000													12	34					1.08611e-07	1.39962e-07	0.387290	1	0
DMXL1	1657	broad.mit.edu	37	5	118486002	118486002	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:118486002C>T	ENST00000311085.8	+	18	4560	c.4480C>T	c.(4480-4482)Ctt>Ttt	p.L1494F	DMXL1_ENST00000539542.1_Missense_Mutation_p.L1494F	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1494										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TGGCCACTTACTTCATTCTAG	0.443000													23	91					0	0	0.639603	0	0
CSMD3	114788	broad.mit.edu	37	8	113662527	113662527	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:113662527C>A	ENST00000297405.5	-	19	3300	c.3056G>T	c.(3055-3057)gGc>gTc	p.G1019V	CSMD3_ENST00000352409.3_Missense_Mutation_p.G1019V|CSMD3_ENST00000455883.2_Missense_Mutation_p.G915V|CSMD3_ENST00000343508.3_Missense_Mutation_p.G979V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1019	Sushi 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATAGCGACGGCCATGTACAGG	0.428000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	134					4.3838e-07	5.47975e-07	0.435327	1	0
DIRAS2	54769	broad.mit.edu	37	9	93376017	93376017	+	Silent	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:93376017T>C	ENST00000375765.3	-	2	481	c.93A>G	c.(91-93)acA>acG	p.T31T		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	31					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						TCTCCCGGAATGTGCCTTTCA	0.567000													27	91					0	0	0.729181	0	0
RYR3	6263	broad.mit.edu	37	15	33941303	33941303	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:33941303G>T	ENST00000389232.4	+	31	4079	c.4009G>T	c.(4009-4011)Gga>Tga	p.G1337*	RYR3_ENST00000415757.3_Nonsense_Mutation_p.G1337*	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1337	4 X approximate repeats.|B30.2/SPRY 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CATCTTTGCTGGACAGGATCC	0.537000													16	53					1.45105e-14	2.26727e-14	0.539581	1	0
HCN3	57657	broad.mit.edu	37	1	155254959	155254959	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:155254959A>G	ENST00000368358.3	+	5	1101	c.1093A>G	c.(1093-1095)Aag>Gag	p.K365E	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	365						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCTCCAGTACAAGCAGGTGGA	0.602000													23	47					0	0	0.654019	0	0
ANK2	287	broad.mit.edu	37	4	114276175	114276175	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:114276175C>A	ENST00000357077.4	+	38	6454	c.6401C>A	c.(6400-6402)aCt>aAt	p.T2134N	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.T2101N	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2101					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAAACCTCCACTGACTTCTCT	0.468000													14	16					4.3838e-07	5.47975e-07	0.435327	1	0
TROAP	10024	broad.mit.edu	37	12	49717643	49717643	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:49717643C>G	ENST00000551245.1	+	3	271	c.160C>G	c.(160-162)Cca>Gca	p.P54A	RP11-161H23.9_ENST00000553259.1_RNA|TROAP_ENST00000550709.1_Missense_Mutation_p.P54A|TROAP_ENST00000549534.1_3'UTR|TROAP_ENST00000549275.1_Intron|TROAP_ENST00000548311.1_Missense_Mutation_p.P54A|TROAP_ENST00000380327.5_Missense_Mutation_p.P54A|TROAP_ENST00000257909.3_Missense_Mutation_p.P54A			Q12815	TROAP_HUMAN	trophinin associated protein	54					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						GGTGCAGAAACCACCGCTCAA	0.557000													10	111					0	0	0.361761	0	0
TMEM245	23731	broad.mit.edu	37	9	111798654	111798654	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:111798654G>A	ENST00000374586.3	-	16	2262	c.2231C>T	c.(2230-2232)gCa>gTa	p.A744V		NM_032012.3	NP_114401.2	Q9H330	CI005_HUMAN	transmembrane protein 245	744						integral to membrane											AAGGATTGCTGCTAATGCTGA	0.443000													4	20					0	0	0.150653	0	0
GRM1	2911	broad.mit.edu	37	6	146755228	146755228	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:146755228G>T	ENST00000361719.2	+	9	3351	c.2881G>T	c.(2881-2883)Gag>Tag	p.E961*	GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000282753.1_Nonsense_Mutation_p.E961*|GRM1_ENST00000492807.2_3'UTR|GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000392299.2_3'UTR	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	961					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AGAGGAGGAGGAGGATGCCCA	0.597000													28	93					9.39395e-14	1.432e-13	0.706142	1	0
CDH10	1008	broad.mit.edu	37	5	24487944	24487944	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:24487944G>T	ENST00000264463.4	-	12	2702	c.2195C>A	c.(2194-2196)tCa>tAa	p.S732*	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	732					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GGTTGCAAGTGAGTCGTAGGG	0.468000										HNSCC(23;0.051)			37	95					2.40579e-17	3.95689e-17	0.819951	1	0
PRKRIP1	79706	broad.mit.edu	37	7	102065499	102065499	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:102065499G>T	ENST00000496391.1	+	10	1806	c.496G>T	c.(496-498)Gcg>Tcg	p.A166S	PRKRIP1_ENST00000354783.4_Missense_Mutation_p.C106F|PRKRIP1_ENST00000482465.1_3'UTR|PRKRIP1_ENST00000462601.1_Missense_Mutation_p.A109S|PRKRIP1_ENST00000397912.3_Missense_Mutation_p.A166S			Q9H875	PKRI1_HUMAN	PRKR interacting protein 1 (IL11 inducible)	166						nucleolus				endometrium(1)|lung(4)|ovary(1)	6						CAGCAGCTCTGCGGAGGCATC	0.562000													10	23					3.07112e-06	3.69836e-06	0.387290	1	0
PTCHD3	374308	broad.mit.edu	37	10	27687884	27687884	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:27687884C>G	ENST00000438700.3	-	4	1760	c.1643G>C	c.(1642-1644)tGc>tCc	p.C548S		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	548					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CCAGCATAGGCAGACTACTTC	0.393000													30	51					0	0	0.740014	0	0
MMP19	4327	broad.mit.edu	37	12	56231055	56231055	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:56231055G>T	ENST00000394182.1	-	4	433	c.434C>A	c.(433-435)gCt>gAt	p.A145D	MMP19_ENST00000409200.3_3'UTR|MMP19_ENST00000322569.4_Missense_Mutation_p.A431D|MMP19_ENST00000548629.1_Missense_Mutation_p.A408D			Q99542	MMP19_HUMAN	matrix metallopeptidase 19	431					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						ACTCATAGCAGCCGAGGGCTG	0.542000													44	90					2.00842e-17	3.31204e-17	0.853193	1	0
ATP13A2	23400	broad.mit.edu	37	1	17331936	17331936	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:17331936C>A	ENST00000452699.1	-	3	410	c.221G>T	c.(220-222)cGg>cTg	p.R74L	ATP13A2_ENST00000326735.8_Missense_Mutation_p.R74L|ATP13A2_ENST00000341676.5_Missense_Mutation_p.R74L	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	74					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		GAGCCGCAGCCGCACCCCCCA	0.602000													11	10					1.08611e-07	1.39962e-07	0.387290	1	0
PZP	5858	broad.mit.edu	37	12	9356441	9356441	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:9356441C>T	ENST00000261336.2	-	2	218	c.190G>A	c.(190-192)Gag>Aag	p.E64K		NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						CTGCCAGACTCCAAGGAAGCA	0.562000													26	53					0	0	0.706142	0	0
KCNA5	3741	broad.mit.edu	37	12	5154798	5154798	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:5154798C>G	ENST00000252321.3	+	1	1714	c.1485C>G	c.(1483-1485)atC>atG	p.I495M		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	495						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						GGGGCAAGATCGTGGGCTCGC	0.602000													29	82					0	0	0.717897	0	0
E2F8	79733	broad.mit.edu	37	11	19259527	19259527	+	Silent	SNP	C	C	G	rs140453196	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:19259527C>G	ENST00000527884.1	-	3	400	c.168G>C	c.(166-168)ccG>ccC	p.P56P	E2F8_ENST00000250024.4_Silent_p.P56P|RP11-428C19.4_ENST00000527978.1_RNA	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	56					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCGGTGTCCACGGCTCTCCCT	0.512000													13	93					0	0	0.435327	0	0
RSG1	79363	broad.mit.edu	37	1	16560187	16560187	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:16560187C>T	ENST00000375599.3	-	2	604	c.185G>A	c.(184-186)gGg>gAg	p.G62E		NM_030907.3	NP_112169.2	Q9BU20	RSG1_HUMAN	REM2 and RAB-like small GTPase 1	62	Small GTPase-like.				cellular protein localization|cilium assembly|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|small GTPase mediated signal transduction	cilium|microtubule basal body	GTP binding			large_intestine(2)|lung(2)|pancreas(1)|prostate(1)	6						ACCACTCTTCCCGGACACAAA	0.627000													10	81					0	0	0.361761	0	0
SMCHD1	23347	broad.mit.edu	37	18	2763760	2763760	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr18:2763760C>T	ENST00000320876.6	+	37	5030	c.4692C>T	c.(4690-4692)ccC>ccT	p.P1564P	RP11-703M24.5_ENST00000583546.1_RNA|SMCHD1_ENST00000261598.8_Silent_p.P1564P	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1564					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						TTGAATTCCCCTTCGTGAATG	0.343000													6	35					0	0	0.217242	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846263	47846263	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:47846263G>A	ENST00000339488.4	-	3	2350	c.2317C>T	c.(2317-2319)Ctt>Ttt	p.L773F		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	773						integral to membrane	hedgehog receptor activity										ACAAATAGAAGGGGGACTAAC	0.433000													17	13					0	0	0.500413	0	0
NR2E1	7101	broad.mit.edu	37	6	108501583	108501583	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:108501583G>T	ENST00000368986.4	+	6	1407	c.699G>T	c.(697-699)tgG>tgT	p.W233C	NR2E1_ENST00000368983.3_Missense_Mutation_p.W270C	NM_003269.3	NP_003260.1	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	233	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		TAGCACAATGGGCCATTCCGG	0.338000													13	30					2.62699e-14	4.06403e-14	0.479597	1	0
CLCA4	22802	broad.mit.edu	37	1	87036772	87036772	+	Missense_Mutation	SNP	C	C	A	rs112479973		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:87036772C>A	ENST00000370563.3	+	8	1237	c.1195C>A	c.(1195-1197)Cta>Ata	p.L399I	CLCA4_ENST00000263723.5_Missense_Mutation_p.L112I	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	399	VWFA.					apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GATTGGAGAGCTACATTCCCA	0.413000													17	141					8.34094e-07	1.0262e-06	0.575678	1	0
TAB2	23118	broad.mit.edu	37	6	149730712	149730712	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:149730712G>T	ENST00000367456.1	+	8	2516		c.e8-1		TAB2_ENST00000538427.1_Splice_Site|TAB2_ENST00000286332.5_Splice_Site|TAB2_ENST00000536230.1_Splice_Site			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2						activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						CTTTCTTACAGATCAAAGGTC	0.368000													23	100					0.000229342	0.000258268	0.608945	1	0
KCTD8	386617	broad.mit.edu	37	4	44177175	44177175	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:44177175A>G	ENST00000360029.3	-	2	1337	c.1054T>C	c.(1054-1056)Tgt>Cgt	p.C352R		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	352						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						AGCTCATTACAGGAAGTCCCA	0.463000										HNSCC(17;0.042)			24	29					0	0	0.639603	0	0
MGAT3	4248	broad.mit.edu	37	22	39883636	39883636	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:39883636G>T	ENST00000341184.6	+	2	499	c.284G>T	c.(283-285)cGg>cTg	p.R95L		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	95					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GAGCTCCACCGGGTGGACTTG	0.692000													11	21					3.07112e-06	3.69836e-06	0.387290	1	0
MARCH4	57574	broad.mit.edu	37	2	217124231	217124231	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:217124231G>T	ENST00000273067.4	-	4	2803	c.1037C>A	c.(1036-1038)tCc>tAc	p.S346Y		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	346						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		CTCTTCCGAGGAGGGGATATT	0.617000													6	27					0.248553	0.252184	0.248553	1	0
AMER3	205147	broad.mit.edu	37	2	131520682	131520682	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:131520682G>T	ENST00000423981.1	+	2	1147	c.1037G>T	c.(1036-1038)gGg>gTg	p.G346V	AMER3_ENST00000321420.4_Missense_Mutation_p.G346V	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GACACAGCTGGGCTCGCTGAG	0.677000													17	20					6.94344e-10	9.51678e-10	0.539581	1	0
PNPLA5	150379	broad.mit.edu	37	22	44280198	44280198	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:44280198G>T	ENST00000216177.4	-	7	1109	c.977C>A	c.(976-978)cCc>cAc	p.P326H	PNPLA5_ENST00000597664.1_Missense_Mutation_p.P326H|PNPLA5_ENST00000593866.1_Missense_Mutation_p.P212H|PNPLA5_ENST00000381198.2_Missense_Mutation_p.P212H	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	326					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				CCACCGGCTGGGATCCCTCGT	0.622000											OREG0026622	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	36					2.5808e-16	4.18961e-16	0.539581	1	0
PLCB1	23236	broad.mit.edu	37	20	8862414	8862414	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:8862414C>A	ENST00000338037.6	+	32	3596	c.3569C>A	c.(3568-3570)cCt>cAt	p.P1190H	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1190					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TCCTCAGACCCTGGAAAAGTG	0.522000													36	144					3.61848e-18	6.04692e-18	0.834066	1	0
ADSSL1	122622	broad.mit.edu	37	14	105208226	105208226	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:105208226G>A	ENST00000332972.5	+	9	1123	c.964G>A	c.(964-966)Ggt>Agt	p.G322S	ADSSL1_ENST00000330877.2_Missense_Mutation_p.G279S	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	279					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CACCGTGGGCGGTGTGTGCAC	0.602000													35	49					0	0	0.834066	0	0
ALKBH3	221120	broad.mit.edu	37	11	43908159	43908159	+	Splice_Site	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:43908159A>G	ENST00000378840.4	+	5	624	c.218_splice	c.e5-1	p.E73_splice	ALKBH3_ENST00000302708.4_Silent_p.R74R|ALKBH3_ENST00000532410.1_3'UTR			Q96Q83	ALKB3_HUMAN	alkB, alkylation repair homolog 3 (E. coli)	73					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|kidney(1)|lung(4)|prostate(1)	8					Vitamin C(DB00126)	TCTTTAGCAGAGAGGGTGTGT	0.413000								Direct reversal of damage					6	44					0	0	0.248553	0	0
ABHD2	11057	broad.mit.edu	37	15	89738465	89738465	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:89738465A>T	ENST00000352732.5	+	11	1609	c.1089A>T	c.(1087-1089)cgA>cgT	p.R363R	ABHD2_ENST00000565973.1_Silent_p.R363R|ABHD2_ENST00000355100.3_Silent_p.R363R	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	363						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					CAGAGAAACGAGAGAACGTCA	0.567000													8	39					0	0	0.278610	0	0
FAM65C	140876	broad.mit.edu	37	20	49225886	49225886	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:49225886C>T	ENST00000327979.2	-	8	983	c.572G>A	c.(571-573)tGg>tAg	p.W191*	FAM65C_ENST00000045083.2_Nonsense_Mutation_p.W191*|FAM65C_ENST00000535356.1_Nonsense_Mutation_p.W195*			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	191										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTCGATGAGCCACATGTCCTG	0.652000													4	17					0	0	0.184627	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728960	15728960	+	RNA	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:15728960T>A	ENST00000441682.2	+	0	407							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CCTCAGGTACTCCTGCAGAGC	0.552000													40	36					0	0	0.859065	0	0
TAPBPL	55080	broad.mit.edu	37	12	6562638	6562638	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:6562638C>A	ENST00000266556.7	+	3	486	c.321C>A	c.(319-321)gcC>gcA	p.A107A	TAPBPL_ENST00000545700.1_3'UTR|TAPBPL_ENST00000544021.1_Silent_p.A30A	NM_018009.4	NP_060479.3	Q9BX59	TPSNR_HUMAN	TAP binding protein-like	107					antigen processing and presentation of endogenous peptide antigen via MHC class I	endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane				endometrium(2)|large_intestine(1)|skin(2)|upper_aerodigestive_tract(1)	6						TTCCCCAGGCCGAGGCCTTGC	0.572000													27	37					1.17739e-12	1.76046e-12	0.693898	1	0
OR5F1	338674	broad.mit.edu	37	11	55761409	55761409	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:55761409C>A	ENST00000278409.1	-	1	692	c.693G>T	c.(691-693)ggG>ggT	p.G231G		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					GCCTCCCCTCCCCCGAATGCA	0.478000													3	27					0.115264	0.118878	0.115264	1	0
TMEM104	54868	broad.mit.edu	37	17	72781696	72781696	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:72781696G>T	ENST00000335464.5	+	3	283	c.121G>T	c.(121-123)Ggg>Tgg	p.G41W	TMEM104_ENST00000582773.1_Missense_Mutation_p.G41W|TMEM104_ENST00000417024.2_Intron|TMEM104_ENST00000582330.1_Missense_Mutation_p.G41W	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	41						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					CGCCACTGCCGGGTGGCTTGT	0.617000													18	48					8.00594e-06	9.51276e-06	0.557998	1	0
RHO	6010	broad.mit.edu	37	3	129252498	129252498	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:129252498G>A	ENST00000296271.3	+	5	1078	c.984G>A	c.(982-984)ctG>ctA	p.L328L		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	328					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	AGAACCCACTGGGTGACGATG	0.617000													7	108					0	0	0.278610	0	0
LIFR	3977	broad.mit.edu	37	5	38482707	38482707	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:38482707T>A	ENST00000263409.4	-	19	2816	c.2654A>T	c.(2653-2655)cAa>cTa	p.Q885L	LIFR_ENST00000453190.2_Missense_Mutation_p.Q885L	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	885					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					GACACTCTTTTGAAACTGTAA	0.259000			T	PLAG1	salivary adenoma								26	76					0	0	0.769981	0	0
RSPO1	284654	broad.mit.edu	37	1	38079564	38079564	+	Splice_Site	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:38079564G>A	ENST00000356545.2	-	7	1224	c.436_splice	c.e7-1	p.A146_splice	RSPO1_ENST00000401069.1_Splice_Site_p.A146_splice|RSPO1_ENST00000401071.2_Intron|RSPO1_ENST00000373059.1_Splice_Site_p.A119_splice|RSPO1_ENST00000401070.1_Intron|RSPO1_ENST00000401068.1_Splice_Site_p.A146_splice	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1	146					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding	p.A146E(1)|p.A146V(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTCACATTGCGCTGGCAGGAA	0.612000													22	23					0	0	0.639603	0	0
SPAG5	10615	broad.mit.edu	37	17	26919183	26919183	+	Missense_Mutation	SNP	C	C	A	rs142483214	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:26919183C>A	ENST00000321765.5	-	3	1411	c.1079G>T	c.(1078-1080)cGc>cTc	p.R360L		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	360					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					TAAGCTTTGGCGGAGATTTTC	0.512000													45	57					5.2432e-18	8.73867e-18	0.870114	1	0
ANO8	57719	broad.mit.edu	37	19	17434337	17434337	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:17434337C>T	ENST00000159087.4	-	18	3846	c.3688G>A	c.(3688-3690)Ggc>Agc	p.G1230S		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	1230						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						TAATGCCAGCCGCTGGGCCAG	0.662000													3	32					0	0	0.115264	0	0
ACACB	32	broad.mit.edu	37	12	109577565	109577565	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:109577565G>T	ENST00000338432.7	+	2	474	c.355G>T	c.(355-357)Ggg>Tgg	p.G119W	ACACB_ENST00000377854.5_Missense_Mutation_p.G119W|ACACB_ENST00000377848.3_Missense_Mutation_p.G119W			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	119					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TCAAGCCAACGGGACTGGGAC	0.622000													50	106					4.37618e-36	8.11607e-36	0.870114	1	0
OR5F1	338674	broad.mit.edu	37	11	55761408	55761408	+	Nonsense_Mutation	SNP	C	C	A	rs138514211		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:55761408C>A	ENST00000278409.1	-	1	693	c.694G>T	c.(694-696)Gag>Tag	p.E232*		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					TGCCTCCCCTCCCCCGAATGC	0.483000													3	27					0.115264	0.118878	0.115264	1	0
GMEB1	10691	broad.mit.edu	37	1	29010251	29010251	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:29010251G>T	ENST00000373816.1	+	2	265	c.128_splice	c.e2+1	p.G43_splice	GMEB1_ENST00000480454.1_3'UTR|GMEB1_ENST00000294409.2_Splice_Site_p.G43_splice|GMEB1_ENST00000361872.4_Splice_Site_p.G43_splice	NM_024482.2	NP_077808.1	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding protein 1	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)	11		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		TGTGCAACAAGGGTAAGTGGC	0.423000													22	28					3.8784e-16	6.26357e-16	0.608945	1	0
SYNE2	23224	broad.mit.edu	37	14	64545201	64545201	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:64545201A>C	ENST00000357395.3	+	55	11270	c.126A>C	c.(124-126)ttA>ttC	p.L42F	SYNE2_ENST00000358025.3_Missense_Mutation_p.L3680F|SYNE2_ENST00000555002.1_Missense_Mutation_p.L314F|SYNE2_ENST00000394768.2_Missense_Mutation_p.L42F|SYNE2_ENST00000554584.1_Missense_Mutation_p.L3713F|SYNE2_ENST00000344113.4_Missense_Mutation_p.L3680F			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3680	Actin-binding.|CH 1.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATGAAGTCTTAAAAAGCTCAC	0.353000													4	34					0	0	0.150653	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179815614	179815614	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:179815614C>A	ENST00000367612.3	-	6	1392	c.1005G>T	c.(1003-1005)agG>agT	p.R335S		NM_001199260.1|NM_145034.4	NP_001186189.1|NP_659471.1	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	335						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(10)|ovary(1)|skin(2)	18						CCTGCCAGGTCCTTCCAGCCC	0.547000													9	72					0.000442599	0.00049134	0.335167	1	0
SP4	6671	broad.mit.edu	37	7	21521557	21521557	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:21521557A>T	ENST00000222584.3	+	5	2141	c.1923A>T	c.(1921-1923)ccA>ccT	p.P641P		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	641					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						GTAATGAACCAGGAAAAAAGA	0.338000													16	96					0	0	0.520397	0	0
VN1R2	317701	broad.mit.edu	37	19	53762039	53762039	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:53762039G>C	ENST00000341702.3	+	1	495	c.411G>C	c.(409-411)ttG>ttC	p.L137F		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	137					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		CTGACTCCTTGGTTATCCTAT	0.368000													28	51					0	0	0.740014	0	0
ANO7	50636	broad.mit.edu	37	2	242149780	242149780	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:242149780G>A	ENST00000274979.8	+	14	1695	c.1592G>A	c.(1591-1593)aGg>aAg	p.R531K	ANO7_ENST00000402430.3_Missense_Mutation_p.R530K	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	531						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						GTGGTGTCCAGGTCGGGCAAC	0.677000													4	31					0	0	0.184627	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46942261	46942261	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:46942261C>A	ENST00000429979.1	-	5	1346	c.742G>T	c.(742-744)Gat>Tat	p.D248Y	KIAA0226L_ENST00000378784.4_Missense_Mutation_p.D181Y|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.D113Y|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.D248Y|KIAA0226L_ENST00000378787.3_Missense_Mutation_p.D248Y|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.D248Y|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.D91Y|KIAA0226L_ENST00000409879.2_Missense_Mutation_p.D91Y|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.D248Y	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	248										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						TCAGGCTGATCACTCCCAAGT	0.408000													62	100					5.73332e-34	1.05392e-33	0.870114	1	0
UBE3B	89910	broad.mit.edu	37	12	109972414	109972414	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:109972414G>C	ENST00000342494.3	+	28	3629	c.3034G>C	c.(3034-3036)Ggc>Cgc	p.G1012R	UBE3B_ENST00000434735.2_Missense_Mutation_p.G1012R	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1012	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						GGACACTCTGGGCAGCGTCCT	0.652000													8	26					0	0	0.335167	0	0
OR2A5	393046	broad.mit.edu	37	7	143748122	143748122	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:143748122C>A	ENST00000408906.2	+	1	662	c.628C>A	c.(628-630)Ccg>Acg	p.P210T		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CCTGGTGGGGCCGCTCTGCCT	0.592000													75	80					3.83446e-41	7.17525e-41	0.870114	1	0
FREM2	341640	broad.mit.edu	37	13	39266287	39266287	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:39266287C>A	ENST00000280481.7	+	1	5022	c.4806C>A	c.(4804-4806)atC>atA	p.I1602I		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1602					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AAAACTTAATCAGCTACAAAC	0.418000													16	54					1.3612e-06	1.66163e-06	0.479597	1	0
MATN2	4147	broad.mit.edu	37	8	99015971	99015971	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:99015971C>A	ENST00000254898.5	+	8	1518	c.1287C>A	c.(1285-1287)caC>caA	p.H429Q	MATN2_ENST00000522025.2_Missense_Mutation_p.H145Q|MATN2_ENST00000524308.1_Missense_Mutation_p.H388Q|MATN2_ENST00000520016.1_Missense_Mutation_p.H429Q|MATN2_ENST00000521689.1_Missense_Mutation_p.H429Q	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	429	EGF-like 5.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GCCGCTGCCACCGTGGCTACA	0.602000													80	12					2.40982e-25	4.27879e-25	0.870114	1	0
LAMB4	22798	broad.mit.edu	37	7	107752255	107752255	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:107752255C>A	ENST00000388781.3	-	4	412		c.e4+1		LAMB4_ENST00000414450.2_Splice_Site|LAMB4_ENST00000205386.4_Splice_Site|LAMB4_ENST00000388780.3_Splice_Site	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4						cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TTAAATCATACCATTTTCAGA	0.338000													12	66					5.50884e-06	6.55814e-06	0.411799	1	0
CELSR2	1952	broad.mit.edu	37	1	109793580	109793580	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:109793580G>A	ENST00000271332.3	+	1	940	c.879G>A	c.(877-879)gaG>gaA	p.E293E		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	293	Cadherin 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		AGCAGCAGGAGTACAAGGAGA	0.582000													4	66					0	0	0.217242	0	0
HIST1H2AE	3012	broad.mit.edu	37	6	26217423	26217423	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:26217423A>T	ENST00000303910.2	+	1	259	c.221A>T	c.(220-222)aAt>aTt	p.N74I		NM_021052.2	NP_066390.1	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	74					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	10		all_hematologic(11;0.196)				GCTCGCGACAATAAGAAGACC	0.617000													10	100					0	0	0.387290	0	0
MMP1	4312	broad.mit.edu	37	11	102668050	102668050	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:102668050T>A	ENST00000315274.6	-	2	354	c.287A>T	c.(286-288)gAt>gTt	p.D96V	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	96					blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		CTGAGCCACATCAGGCACTCC	0.512000													9	47					0	0	0.307466	0	0
TAOK2	9344	broad.mit.edu	37	16	29994574	29994574	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:29994574C>T	ENST00000308893.4	+	12	2224	c.1181C>T	c.(1180-1182)cCt>cTt	p.P394L	TAOK2_ENST00000279394.3_Missense_Mutation_p.P394L|TAOK2_ENST00000416441.2_Missense_Mutation_p.P221L|TAOK2_ENST00000543033.1_Missense_Mutation_p.P394L	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	394	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						gaagaAGGCCCTGAAGCCCGG	0.617000													8	21					0	0	0.307466	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643084	1643084	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:1643084G>T	ENST00000399682.1	-	1	284	c.240C>A	c.(238-240)ggC>ggA	p.G80G		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	80	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AAGAGCCATAGCCCCCCTTGG	0.662000													39	46					4.64027e-19	7.85953e-19	0.870114	1	0
TBC1D15	64786	broad.mit.edu	37	12	72316795	72316795	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:72316795G>T	ENST00000550746.1	+	18	1951	c.1887G>T	c.(1885-1887)ggG>ggT	p.G629G	TBC1D15_ENST00000393309.3_Silent_p.G383G|TBC1D15_ENST00000319106.8_Silent_p.G620G|TBC1D15_ENST00000485960.2_Silent_p.G612G	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	629							protein binding|Rab GTPase activator activity	p.G629G(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGATCCTTGGGCTTCAAGGCA	0.398000													16	47					3.32936e-07	4.21225e-07	0.539581	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43777627	43777627	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:43777627T>A	ENST00000389420.3	-	30	4605	c.4606A>T	c.(4606-4608)Atg>Ttg	p.M1536L		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1536	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCTCTTTCCATCCCCTTGTGC	0.438000													12	95					0	0	0.411799	0	0
FRYL	285527	broad.mit.edu	37	4	48636308	48636308	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:48636308C>A	ENST00000358350.4	-	4	724	c.120_splice	c.e4+1	p.L40_splice	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507711.1_Splice_Site_p.L40_splice|FRYL_ENST00000503238.1_Splice_Site_p.L40_splice|FRYL_ENST00000537810.1_Splice_Site_p.L40_splice	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	40					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CTGTACTCACCAAGGGTTCGG	0.338000													37	39					2.05212e-20	3.5139e-20	0.812448	1	0
GCK	2645	broad.mit.edu	37	7	44197682	44197682	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:44197682G>T	ENST00000395796.3	-	2	316	c.32C>A	c.(31-33)cCc>cAc	p.P11H	GCK_ENST00000476008.1_Intron|GCK_ENST00000403799.3_Intron|GCK_ENST00000345378.2_Intron|GCK_ENST00000437084.1_Intron	NM_033508.1	NP_277043.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	0			A -> T.		cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						CTGggagttgggttgtgggag	0.542000													24	18					9.57634e-11	1.33897e-10	0.654019	1	0
IFI16	3428	broad.mit.edu	37	1	158984735	158984735	+	Splice_Site	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:158984735G>C	ENST00000295809.7	+	2	520	c.265_splice	c.e2+1	p.V89_splice	IFI16_ENST00000359709.3_Splice_Site_p.V89_splice|IFI16_ENST00000448393.2_Splice_Site_p.V89_splice|IFI16_ENST00000368131.4_Splice_Site_p.V89_splice|IFI16_ENST00000430894.2_Splice_Site_p.V93_splice|IFI16_ENST00000368132.3_Splice_Site_p.V89_splice|IFI16_ENST00000340979.6_Splice_Site_p.V89_splice			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	89	Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					AAAGTTAAAAGGTAATTGGGA	0.443000													4	60					0	0	0.150653	0	0
PDE4B	5142	broad.mit.edu	37	1	66458793	66458793	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:66458793G>T	ENST00000423207.2	+	1	689	c.204G>T	c.(202-204)cgG>cgT	p.R68R	PDE4B_ENST00000371049.3_Intron|PDE4B_ENST00000329654.4_Intron	NM_001037340.1	NP_001032417.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	179					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	AAAGCATTCGGCAGCGTCGTC	0.448000													32	31					2.68265e-12	3.97312e-12	0.769981	1	0
FSTL4	23105	broad.mit.edu	37	5	132561401	132561401	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:132561401T>C	ENST00000265342.7	-	9	1375	c.1126A>G	c.(1126-1128)Aaa>Gaa	p.K376E	FSTL4_ENST00000507112.1_5'UTR	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	376	Ig-like 2.					extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACGCCGTTTTTCAGCCAAGTG	0.517000													15	75					0	0	0.457914	0	0
SEC14L1	6397	broad.mit.edu	37	17	75208130	75208130	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:75208130G>A	ENST00000413679.2	+	15	2013	c.1710G>A	c.(1708-1710)tcG>tcA	p.S570S	SEC14L1_ENST00000431431.2_Silent_p.S536S|SEC14L1_ENST00000443798.4_Silent_p.S570S|SEC14L1_ENST00000392476.2_Silent_p.S570S|SEC14L1_ENST00000436233.4_Silent_p.S570S|SEC14L1_ENST00000430767.4_Silent_p.S570S|SEC14L1_ENST00000591437.1_Silent_p.S536S|SEC14L1_ENST00000585618.1_Silent_p.S570S	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	570	GOLD.				transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						CCAAGAGGTCGCCACAACCAC	0.527000													28	282					0	0	0.750413	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369560	86369560	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr13:86369560G>T	ENST00000400286.2	-	2	1682	c.1084C>A	c.(1084-1086)Ccg>Acg	p.P362T		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	362						integral to membrane		p.P362T(1)		breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GGATTTTGCGGAGGAGGTCTC	0.413000													11	70					9.70103e-10	1.32383e-09	0.361761	1	0
TEX2	55852	broad.mit.edu	37	17	62290241	62290241	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:62290241G>T	ENST00000258991.3	-	2	1421	c.1337C>A	c.(1336-1338)cCa>cAa	p.P446Q	TEX2_ENST00000583097.1_Missense_Mutation_p.P446Q|TEX2_ENST00000584379.1_Missense_Mutation_p.P446Q			Q8IWB9	TEX2_HUMAN	testis expressed 2	446				P -> S (in Ref. 2; CAH10519).	signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		GAGCACCTCTGGCTTGAGAGG	0.507000													66	101					3.00467e-41	5.63939e-41	0.870114	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3673738	3673738	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:3673738G>T	ENST00000344754.4	-	14	3548	c.3549C>A	c.(3547-3549)agC>agA	p.S1183R	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.S1183R	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1183	Ig-like C2-type 12.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCCCGCCATGGCTCTCCAGGA	0.692000													7	21					0.00307968	0.00331862	0.278610	1	0
PTN	5764	broad.mit.edu	37	7	136938254	136938254	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:136938254G>T	ENST00000348225.2	-	3	673	c.246C>A	c.(244-246)acC>acA	p.T82T	PTN_ENST00000393083.2_Silent_p.T82T	NM_002825.5	NP_002816.1	P21246	PTN_HUMAN	pleiotrophin	82					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23						TACATCTCTGGGTCTTCATGG	0.512000													23	40					5.45024e-15	8.55879e-15	0.654019	1	0
ISM1	140862	broad.mit.edu	37	20	13279910	13279910	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:13279910C>G	ENST00000262487.3	+	6	1205	c.1199C>G	c.(1198-1200)gCg>gGg	p.A400G	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	400	AMOP.					extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						GGCAAGGGGGCGGGCACGCCC	0.622000													4	7					0	0	0.150653	0	0
CNOT1	23019	broad.mit.edu	37	16	58568148	58568148	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:58568148T>A	ENST00000317147.5	-	40	6130	c.5798A>T	c.(5797-5799)tAt>tTt	p.Y1933F	CNOT1_ENST00000245138.4_Missense_Mutation_p.Y784F|CNOT1_ENST00000569240.1_Missense_Mutation_p.Y1928F	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1933					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CAGGTTGTGATAGCACTTGGC	0.502000													17	28					0	0	0.500413	0	0
OR2T5	401993	broad.mit.edu	37	1	248651971	248651971	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:248651971C>T	ENST00000366473.2	+	1	87	c.82C>T	c.(82-84)Cca>Tca	p.P28S		NM_001004697.1	NP_001004697.1	Q6IEZ7	OR2T5_HUMAN	olfactory receptor, family 2, subfamily T, member 5	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(2)|pancreas(1)|skin(2)	9	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCCAAACATCCAGCTCTACT	0.502000													9	128					0	0	0.435327	0	0
TG	7038	broad.mit.edu	37	8	133899667	133899667	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:133899667G>T	ENST00000220616.4	+	9	2090	c.2050G>T	c.(2050-2052)Gtc>Ttc	p.V684F	TG_ENST00000377869.1_Missense_Mutation_p.V684F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	684	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACCTTGTTTGTCCCTGCTTG	0.557000													5	89					0.014758	0.0155021	0.184627	1	0
FLG2	388698	broad.mit.edu	37	1	152326750	152326750	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:152326750G>T	ENST00000388718.5	-	3	3584	c.3512C>A	c.(3511-3513)tCt>tAt	p.S1171Y	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1171	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTGAGCCAGACTCATGTTG	0.493000													32	109					1.39806e-14	2.18994e-14	0.729181	1	0
AMER3	205147	broad.mit.edu	37	2	131520173	131520173	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:131520173G>T	ENST00000423981.1	+	2	638	c.528G>T	c.(526-528)tcG>tcT	p.S176S	AMER3_ENST00000321420.4_Silent_p.S176S	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		ACTTGGCCTCGCTGGCGGCCG	0.642000													18	59					5.03518e-11	7.13603e-11	0.557998	1	0
KLHL2	11275	broad.mit.edu	37	4	166141117	166141117	+	Missense_Mutation	SNP	G	G	T	rs143711077		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:166141117G>T	ENST00000226725.6	+	2	317	c.58G>T	c.(58-60)Gat>Tat	p.D20Y	KLHL2_ENST00000514860.1_Missense_Mutation_p.D24Y|KLHL2_ENST00000538127.1_5'UTR	NM_007246.3	NP_009177.3	O95198	KLHL2_HUMAN	kelch-like family member 2	20					intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity			endometrium(3)|large_intestine(5)|lung(4)|prostate(1)|urinary_tract(1)	14	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		GAAGCCTCTCGATTCAAAAGA	0.348000													9	30					1.76689e-08	2.33964e-08	0.335167	1	0
LRFN5	145581	broad.mit.edu	37	14	42356305	42356305	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:42356305A>G	ENST00000554171.1	+	5	2909	c.477A>G	c.(475-477)ctA>ctG	p.L159L	LRFN5_ENST00000554120.1_Silent_p.L159L|LRFN5_ENST00000298119.4_Silent_p.L159L			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	159						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		ATAATAATCTAGAAACCATTC	0.408000										HNSCC(30;0.082)			11	65					0	0	0.387290	0	0
GPR98	84059	broad.mit.edu	37	5	89985819	89985819	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:89985819G>T	ENST00000405460.2	+	30	6728	c.6632G>T	c.(6631-6633)gGa>gTa	p.G2211V		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	2211					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GAAACAACAGGAGGAGCCAGA	0.403000													3	4					0.004672	0.00496599	0.115264	1	0
ULK1	8408	broad.mit.edu	37	12	132400695	132400695	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:132400695C>T	ENST00000321867.4	+	19	2220	c.1869C>T	c.(1867-1869)tcC>tcT	p.S623S		NM_003565.2	NP_003556.1	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	623					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TCCTGGGCTCCCCCACCAAGG	0.662000													6	17					0	0	0.307466	0	0
ASTL	431705	broad.mit.edu	37	2	96795647	96795647	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:96795647G>T	ENST00000342380.2	-	8	789	c.790C>A	c.(790-792)Cga>Aga	p.R264R		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	264					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						AGGTTCCATCGCTGGCCGATG	0.667000													7	44					0.00198382	0.00214513	0.248553	1	0
AXDND1	126859	broad.mit.edu	37	1	179399720	179399720	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:179399720T>C	ENST00000367618.3	+	14	1853	c.1466T>C	c.(1465-1467)aTc>aCc	p.I489T	AXDND1_ENST00000461179.2_3'UTR|AXDND1_ENST00000457238.2_Missense_Mutation_p.I489T	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	489										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GATGGGCTTATCAAATGGCAG	0.363000													12	79					0	0	0.520397	0	0
LIPC	3990	broad.mit.edu	37	15	58834784	58834784	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:58834784G>T	ENST00000414170.3	+	5	795	c.508G>T	c.(508-510)Ggt>Tgt	p.G170C	LIPC_ENST00000299022.5_Missense_Mutation_p.G170C|LIPC_ENST00000433326.2_Missense_Mutation_p.G109C|LIPC_ENST00000356113.6_Missense_Mutation_p.G170C			P11150	LIPC_HUMAN	lipase, hepatic	170					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		GTACAGCCTGGGTGCACACGT	0.532000													19	55					1.00905e-13	1.53071e-13	0.575678	1	0
MYH11	4629	broad.mit.edu	37	16	15818569	15818569	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr16:15818569G>T	ENST00000338282.6	-	30	4157	c.4051C>A	c.(4051-4053)Cag>Aag	p.Q1351K	NDE1_ENST00000571896.1_3'UTR|NDE1_ENST00000396354.1_3'UTR|NDE1_ENST00000396355.1_3'UTR|NDE1_ENST00000342673.5_3'UTR|MYH11_ENST00000452625.2_Missense_Mutation_p.Q1358K|MYH11_ENST00000300036.5_Missense_Mutation_p.Q1351K|MYH11_ENST00000576790.1_Missense_Mutation_p.Q1351K|MYH11_ENST00000396324.3_Missense_Mutation_p.Q1358K	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1351					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TCGTCCAGCTGGTCTTGCAGG	0.587000			T	CBFB	AML								18	91					1.01871e-10	1.42119e-10	0.575678	1	0
TTN	7273	broad.mit.edu	37	2	179631224	179631224	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:179631224T>C	ENST00000589042.1	-	41	9811	c.9587A>G	c.(9586-9588)tAt>tGt	p.Y3196C	TTN_ENST00000360870.5_Missense_Mutation_p.Y3196C|TTN_ENST00000359218.5_Missense_Mutation_p.Y3150C|TTN_ENST00000460472.2_Missense_Mutation_p.Y3150C|TTN_ENST00000342175.6_Missense_Mutation_p.Y3150C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.Y3196C|TTN_ENST00000591111.1_Missense_Mutation_p.Y3196C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2929							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCACTACATATTTGTGTCG	0.428000													8	87					0	0	0.278610	0	0
HAVCR1	26762	broad.mit.edu	37	5	156464287	156464287	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:156464287A>C	ENST00000339252.3	-	6	1455	c.923T>G	c.(922-924)cTt>cGt	p.L308R	HAVCR1_ENST00000425854.1_Missense_Mutation_p.L308R|HAVCR1_ENST00000544197.1_Missense_Mutation_p.L308R|HAVCR1_ENST00000517644.1_5'UTR|HAVCR1_ENST00000522693.1_Missense_Mutation_p.L308R|HAVCR1_ENST00000523175.1_Missense_Mutation_p.L308R	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	303					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAAAAGAGCAAGAAGCACCAA	0.423000													10	75					0	0	0.387290	0	0
POU1F1	5449	broad.mit.edu	37	3	87322560	87322560	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:87322560G>T	ENST00000350375.2	-	2	275	c.151C>A	c.(151-153)Ctt>Att	p.L51I	POU1F1_ENST00000560656.1_Missense_Mutation_p.L51I|POU1F1_ENST00000344265.3_Missense_Mutation_p.L77I	NM_000306.2	NP_000297.1	P28069	PIT1_HUMAN	POU class 1 homeobox 1	51					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(2)	18	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		GAATAATGAAGTCCTGTTGCT	0.393000													4	44					0.00909568	0.00958651	0.150653	1	0
OR4C16	219428	broad.mit.edu	37	11	55339908	55339908	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:55339908C>G	ENST00000314634.3	+	1	305	c.305C>G	c.(304-306)tCc>tGc	p.S102C		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				GTCTTTTCATCCCATGTCTTT	0.478000													92	117					0	0	0.870114	0	0
BRPF3	27154	broad.mit.edu	37	6	36168953	36168953	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:36168953G>A	ENST00000357641.6	+	2	1107	c.854G>A	c.(853-855)gGg>gAg	p.G285E	BRPF3_ENST00000543502.1_Missense_Mutation_p.G285E|BRPF3_ENST00000534694.1_Missense_Mutation_p.G285E|BRPF3_ENST00000534400.1_Missense_Mutation_p.G285E|BRPF3_ENST00000339717.7_Missense_Mutation_p.G285E|BRPF3_ENST00000443324.2_Missense_Mutation_p.G285E	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	285					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						ACCAGTGATGGGCACTGGGCC	0.572000													31	51					0	0	0.740014	0	0
BOC	91653	broad.mit.edu	37	3	113002307	113002307	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:113002307C>A	ENST00000495514.1	+	16	3185	c.2481C>A	c.(2479-2481)gcC>gcA	p.A827A	BOC_ENST00000273395.4_Silent_p.A828A|BOC_ENST00000355385.3_Silent_p.A827A			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	827					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			CAACTCTGGCCCCACCACAGC	0.582000													46	76					1.00953e-15	1.62199e-15	0.864702	1	0
PPFIBP1	8496	broad.mit.edu	37	12	27840339	27840339	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:27840339G>T	ENST00000318304.8	+	24	2570	c.2287G>T	c.(2287-2289)Gtt>Ttt	p.V763F	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.V732F|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.V757F|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.V610F	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	763	SAM 2.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GTCTCTGAAGGTTGTAAGTGT	0.468000													10	84					1.76689e-08	2.33964e-08	0.335167	1	0
ZBTB22	9278	broad.mit.edu	37	6	33283774	33283774	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:33283774G>A	ENST00000431845.2	-	2	1071	c.920C>T	c.(919-921)cCa>cTa	p.P307L	ZBTB22_ENST00000418724.1_Missense_Mutation_p.P307L	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						TGTTGGCGCTGGGCAATTACC	0.562000													23	78					0	0	0.608945	0	0
HDAC9	9734	broad.mit.edu	37	7	18687590	18687590	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:18687590A>G	ENST00000406451.3	+	10	1359	c.1209A>G	c.(1207-1209)gaA>gaG	p.E403E	HDAC9_ENST00000441542.2_Silent_p.E406E|HDAC9_ENST00000428307.2_Silent_p.E359E|HDAC9_ENST00000524023.1_Silent_p.E326E|HDAC9_ENST00000405010.3_Silent_p.E403E|HDAC9_ENST00000417496.2_Silent_p.E401E|HDAC9_ENST00000401921.1_Silent_p.E362E|HDAC9_ENST00000432645.2_Silent_p.E403E|HDAC9_ENST00000406072.1_Silent_p.E390E|HDAC9_ENST00000456174.2_Silent_p.E375E	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	403					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TATTGAAAGAACAAATGCGAC	0.443000													3	20					0	0	0.115264	0	0
IL12A	3592	broad.mit.edu	37	3	159711625	159711625	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:159711625G>T	ENST00000305579.2	+	6	907	c.600G>T	c.(598-600)ctG>ctT	p.L200L	IL12A_ENST00000480787.1_Silent_p.L162L|CTD-2049J23.2_ENST00000497452.1_RNA|IL12A_ENST00000466512.1_Silent_p.L186L	NM_000882.3	NP_000873.2	P29459	IL12A_HUMAN	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	166					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	9			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTGATGAGCTGATGCAGGTAA	0.418000													27	155					2.09667e-21	3.60996e-21	0.788014	1	0
KAT6A	7994	broad.mit.edu	37	8	41794835	41794835	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:41794835C>A	ENST00000396930.3	-	17	3834	c.3291G>T	c.(3289-3291)caG>caT	p.Q1097H	KAT6A_ENST00000406337.1_Missense_Mutation_p.Q1097H|KAT6A_ENST00000265713.2_Missense_Mutation_p.Q1097H	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1097					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TAGAAGAGGACTGACACCTGA	0.408000													41	28					2.45108e-15	3.8685e-15	0.840704	1	0
MYO7A	4647	broad.mit.edu	37	11	76922335	76922335	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:76922335G>T	ENST00000409709.3	+	45	6462	c.6190G>T	c.(6190-6192)Gtg>Ttg	p.V2064L	MYO7A_ENST00000409619.2_Missense_Mutation_p.V2015L|MYO7A_ENST00000458637.2_Missense_Mutation_p.V2026L|MYO7A_ENST00000605744.1_3'UTR	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	2064	FERM 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCGGGAGCTGGTGCCCCAGGA	0.652000													3	5					0.004672	0.00496599	0.115264	1	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261651	39261651	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:39261651C>G	ENST00000391415.1	+	1	68	c.11C>G	c.(10-12)tCc>tGc	p.S4C		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	4						keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						ATGGTCAGCTCCTGTTGTGGC	0.592000													19	23					0	0	0.575678	0	0
COL13A1	1305	broad.mit.edu	37	10	71707071	71707071	+	Silent	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:71707071T>C	ENST00000356340.3	+	36	2534	c.1998T>C	c.(1996-1998)caT>caC	p.H666H	COL13A1_ENST00000354547.3_Silent_p.H644H|COL13A1_ENST00000398968.3_Silent_p.H647H|COL13A1_ENST00000398966.3_Silent_p.H644H|COL13A1_ENST00000520267.1_Silent_p.H594H|COL13A1_ENST00000398974.3_Silent_p.H654H|COL13A1_ENST00000520133.1_Silent_p.H588H|COL13A1_ENST00000398972.3_Silent_p.H652H|COL13A1_ENST00000522165.1_Silent_p.H635H|COL13A1_ENST00000517713.1_Silent_p.H617H|COL13A1_ENST00000398971.3_Silent_p.H651H|COL13A1_ENST00000398964.3_Silent_p.H637H|COL13A1_ENST00000398973.3_Silent_p.H640H|COL13A1_ENST00000398978.3_Silent_p.H666H|COL13A1_ENST00000357811.3_Silent_p.H632H|COL13A1_ENST00000398969.3_Silent_p.H594H			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	666	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AGGGTTTACATGGACCACCCG	0.512000													9	25					0	0	0.435327	0	0
TGS1	96764	broad.mit.edu	37	8	56717541	56717541	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:56717541G>A	ENST00000260129.5	+	10	2566	c.2089G>A	c.(2089-2091)Gca>Aca	p.A697T		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	697	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TGTAGTAGACGCATTCTGTGG	0.428000													93	19					0	0	0.870114	0	0
MAP2	4133	broad.mit.edu	37	2	210560055	210560055	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:210560055G>T	ENST00000360351.4	+	7	3667	c.3161G>T	c.(3160-3162)gGa>gTa	p.G1054V	MAP2_ENST00000199940.6_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.G1050V|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000392194.1_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1054					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGTGACTTTGGACAGATGGCT	0.468000													11	64					6.40141e-05	7.35456e-05	0.387290	1	0
OR56A3	390083	broad.mit.edu	37	11	5969306	5969306	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:5969306A>T	ENST00000329564.6	+	1	737	c.730A>T	c.(730-732)Aca>Tca	p.T244S		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCCTAAGCACATGTGGCTC	0.522000													22	120					0	0	0.624587	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643422	37643422	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:37643422T>C	ENST00000356958.4	-	5	1637	c.1379A>G	c.(1378-1380)cAc>cGc	p.H460R	ZNF585A_ENST00000292841.5_Missense_Mutation_p.H405R|ZNF585A_ENST00000355533.2_Intron|ZNF585A_ENST00000588723.1_Intron|ZNF585A_ENST00000392157.2_Missense_Mutation_p.H405R			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCTCCTGTGTGAATTCGTTT	0.398000													14	135					0	0	0.479597	0	0
WDR52	55779	broad.mit.edu	37	3	113092327	113092327	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:113092327T>A	ENST00000393845.2	-	18	2441	c.2375A>T	c.(2374-2376)aAa>aTa	p.K792I	WDR52_ENST00000295868.2_Missense_Mutation_p.K792I	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	792										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						AGGTTCATCTTTTTGTTCTTT	0.368000													8	31					0	0	0.278610	0	0
PAM	5066	broad.mit.edu	37	5	102309956	102309956	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:102309956G>C	ENST00000438793.3	+	14	1769	c.1299G>C	c.(1297-1299)aaG>aaC	p.K433N	PAM_ENST00000348126.2_Intron|PAM_ENST00000304400.7_Missense_Mutation_p.K433N|PAM_ENST00000274392.9_Missense_Mutation_p.K336N|PAM_ENST00000455264.2_Missense_Mutation_p.K433N|PAM_ENST00000379787.4_5'UTR|PAM_ENST00000346918.2_Missense_Mutation_p.K433N	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	433	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	TCCAAAAAAAGGATCTTGGTC	0.413000													8	59					0	0	0.278610	0	0
RYR1	6261	broad.mit.edu	37	19	38960151	38960151	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:38960151G>T	ENST00000355481.4	+	27	3894	c.3763G>T	c.(3763-3765)Gag>Tag	p.E1255*	RYR1_ENST00000359596.3_Nonsense_Mutation_p.E1255*|RYR1_ENST00000360985.3_Nonsense_Mutation_p.E1255*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1255	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCTCACTATGAGGTAAGGAC	0.532000													26	34					1.64293e-13	2.48628e-13	0.654019	1	0
GIMAP1	170575	broad.mit.edu	37	7	150417416	150417416	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:150417416G>A	ENST00000307194.5	+	3	464	c.324G>A	c.(322-324)tcG>tcA	p.S108S		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCTGCTCTCGGCCCCCGGAC	0.637000													8	36					0	0	0.307466	0	0
FAT4	79633	broad.mit.edu	37	4	126242649	126242649	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr4:126242649A>C	ENST00000394329.3	+	1	5096	c.5083A>C	c.(5083-5085)Att>Ctt	p.I1695L		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1695	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GACCGCAGCCATTCTGGACCG	0.433000													8	82					0	0	0.307466	0	0
MANSC1	54682	broad.mit.edu	37	12	12483103	12483103	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:12483103A>G	ENST00000535902.1	-	4	1717	c.1154T>C	c.(1153-1155)cTt>cCt	p.L385P	MANSC1_ENST00000396349.3_Missense_Mutation_p.L351P|MANSC1_ENST00000545735.1_Missense_Mutation_p.L304P			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	385						integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CCCGATAAGAAGCCATTTTTC	0.522000													10	66					0	0	0.361761	0	0
PDZRN3	23024	broad.mit.edu	37	3	73657834	73657834	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr3:73657834C>A	ENST00000263666.4	-	2	839	c.723_splice	c.e2-1	p.G242_splice	PDZRN3_ENST00000308537.4_Splice_Site_p.G242_splice	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	242							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GGTTTCTTCGCCCTGCAGGTA	0.433000													3	7					0.115264	0.118878	0.115264	1	0
TNXB	7148	broad.mit.edu	37	6	32053672	32053672	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:32053672C>A	ENST00000375244.3	-	7	3204	c.3003G>T	c.(3001-3003)ccG>ccT	p.P1001P	TNXB_ENST00000375247.2_Silent_p.P1001P			P22105	TENX_HUMAN	tenascin XB	1088	Fibronectin type-III 2.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CATGTGCCCCCGGCCCCTCGG	0.667000													11	46					7.93312e-07	9.77949e-07	0.457914	1	0
AGMO	392636	broad.mit.edu	37	7	15430465	15430465	+	Splice_Site	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:15430465C>T	ENST00000342526.3	-	7	911	c.742_splice	c.e7+1	p.G248_splice		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	248					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						TTTTACTTACCAAAAATTTTA	0.264000													7	22					0	0	0.248553	0	0
CGB1	114335	broad.mit.edu	37	19	49539443	49539443	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:49539443C>T	ENST00000301407.7	-	2	231	c.127G>A	c.(127-129)Gtg>Atg	p.V43M	CGB1_ENST00000391869.3_Missense_Mutation_p.V43M|CTB-60B18.6_ENST00000591656.1_Intron	NM_033377.1	NP_203695.2	A6NKQ9	CGB1_HUMAN	chorionic gonadotropin, beta polypeptide 1	75						extracellular region	hormone activity	p.V43L(1)		liver(1)|lung(1)	2		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		GTGATGCACACGGGGCAGCCC	0.682000													19	80					0	0	0.624587	0	0
USH2A	7399	broad.mit.edu	37	1	215847758	215847758	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:215847758G>T	ENST00000366943.2	-	63	13881	c.13495C>A	c.(13495-13497)Ctc>Atc	p.L4499I	USH2A_ENST00000307340.3_Missense_Mutation_p.L4499I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4499	Fibronectin type-III 30.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCTGGGGTGAGAGTAAAATCA	0.478000										HNSCC(13;0.011)			18	151					9.16793e-09	1.21914e-08	0.520397	1	0
EIF4E1B	253314	broad.mit.edu	37	5	176070229	176070229	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:176070229C>A	ENST00000318682.6	+	4	746	c.162C>A	c.(160-162)ccC>ccA	p.P54P	EIF4E1B_ENST00000504597.1_Silent_p.P54P	NM_001099408.1	NP_001092878.1	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E family member 1B	54					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			breast(1)|large_intestine(1)|lung(2)|pancreas(1)	5	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGGGGGCCCCATGGAAGTCA	0.617000													9	38					2.17888e-05	2.55018e-05	0.335167	1	0
KRT4	3851	broad.mit.edu	37	12	53207760	53207760	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:53207760C>A	ENST00000551956.1	-	1	575	c.83G>T	c.(82-84)gGt>gTt	p.G28V	KRT4_ENST00000458244.2_Missense_Mutation_p.G28V|KRT4_ENST00000293774.4_Missense_Mutation_p.G102V			B4DRS2	B4DRS2_HUMAN	keratin 4	28						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						GCTGAAGGCACCTCTCTTGCC	0.607000													12	113					0.000978159	0.00107632	0.387290	1	0
AGO4	192670	broad.mit.edu	37	1	36299598	36299598	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:36299598A>T	ENST00000373210.3	+	12	1632	c.1387A>T	c.(1387-1389)Act>Tct	p.T463S		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		CAGGAGTTTCACTGACCAGCT	0.413000													18	37					0	0	0.539581	0	0
TRRAP	8295	broad.mit.edu	37	7	98491471	98491471	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:98491471A>G	ENST00000359863.4	+	6	626	c.417A>G	c.(415-417)ctA>ctG	p.L139L	TRRAP_ENST00000355540.3_Silent_p.L139L|TRRAP_ENST00000446306.3_Silent_p.L139L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	139					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTATTGAGCTACACAAACAGT	0.294000													10	71					0	0	0.335167	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370470	38370470	+	Silent	SNP	C	C	G	rs150656160	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:38370470C>G	ENST00000322350.5	+	6	964	c.618C>G	c.(616-618)ctC>ctG	p.L206L	EGFLAM_ENST00000354891.3_Silent_p.L206L	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	206	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TCAAGGGCCTCGATCCAGATA	0.522000													25	32					0	0	0.654019	0	0
UBBP4	23666	broad.mit.edu	37	17	21731176	21731176	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:21731176C>A	ENST00000584755.1	+	2	875	c.478C>A	c.(478-480)Ctg>Atg	p.L160M	UBBP4_ENST00000578713.1_Missense_Mutation_p.L160M|UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000583708.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						CGTGAAGACCCTGACCGGCAA	0.537000													25	69					1.04121e-07	1.35293e-07	0.693898	1	0
PCDH11X	27328	broad.mit.edu	37	X	91131884	91131884	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:91131884C>A	ENST00000373094.1	+	2	1490	c.645C>A	c.(643-645)taC>taA	p.Y215*	PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000395337.2_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000504220.1_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000361724.1_Nonsense_Mutation_p.Y215*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	215	Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						AGGATACCTACGTGATGAAAG	0.408000													25	69					4.75821e-42	8.95748e-42	0.870114	1	0
OR51F1	256892	broad.mit.edu	37	11	4790663	4790663	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:4790663A>C	ENST00000380383.1	-	1	505	c.506T>G	c.(505-507)cTt>cGt	p.L169R	OR51F1_ENST00000343430.3_Missense_Mutation_p.L162R|MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	162						integral to membrane	olfactory receptor activity	p.L162R(1)		kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		AAGGAGCAAAAGTAGTGGCAA	0.398000													9	73					0	0	0.335167	0	0
COL11A1	1301	broad.mit.edu	37	1	103345402	103345402	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:103345402G>T	ENST00000358392.2	-	66	5464	c.5147C>A	c.(5146-5148)gCc>gAc	p.A1716D	COL11A1_ENST00000353414.4_Missense_Mutation_p.A1665D|COL11A1_ENST00000370096.3_Missense_Mutation_p.A1704D|COL11A1_ENST00000512756.1_Missense_Mutation_p.A1588D	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1704	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCGAGCAGAGGCAGTCAGAAG	0.413000													8	59					2.74318e-10	3.80152e-10	0.335167	1	0
SNX7	51375	broad.mit.edu	37	1	99167426	99167426	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:99167426A>C	ENST00000370189.5	+	8	1264	c.900A>C	c.(898-900)gaA>gaC	p.E300D	SNX7_ENST00000306121.3_Missense_Mutation_p.E364D|SNX7_ENST00000529992.1_Missense_Mutation_p.E309D			Q9UNH6	SNX7_HUMAN	sorting nexin 7	300					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		CCAAAGTTGAAGTTTTGACCT	0.294000													19	124					0	0	0.557998	0	0
FAM47C	442444	broad.mit.edu	37	X	37026658	37026658	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:37026658C>T	ENST00000358047.3	+	1	227	c.175C>T	c.(175-177)Cgc>Tgc	p.R59C		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	59										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGACGACTTCCGCTACGGCTG	0.557000													11	37					0	0	0.361761	0	0
CTSV	1515	broad.mit.edu	37	9	99795258	99795258	+	Silent	SNP	G	G	A	rs149018053		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:99795258G>A	ENST00000259470.5	-	8	1227	c.978C>T	c.(976-978)gcC>gcT	p.A326A	CTSV_ENST00000538255.1_Silent_p.A326A	NM_001333.3	NP_001324.2			cathepsin V																		TGGCTGCTGTGGCGATTCCAC	0.473000													16	37					0	0	0.520397	0	0
PHF20L1	51105	broad.mit.edu	37	8	133855062	133855062	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr8:133855062A>T	ENST00000395386.2	+	19	2989	c.2690A>T	c.(2689-2691)cAc>cTc	p.H897L	AF230666.2_ENST00000429151.1_RNA|PHF20L1_ENST00000395390.2_Missense_Mutation_p.H872L|PHF20L1_ENST00000220847.7_Missense_Mutation_p.H284L	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	897							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			CAAGAATTCCACATGAGAAGT	0.383000													111	39					0	0	0.870114	0	0
TGM6	343641	broad.mit.edu	37	20	2411240	2411240	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:2411240C>A	ENST00000202625.2	+	11	1888	c.1827C>A	c.(1825-1827)acC>acA	p.T609T	TGM6_ENST00000381423.1_Silent_p.T609T	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	609					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	ACTTCATCACCATCAAGGTGA	0.547000													12	35					3.07112e-06	3.69836e-06	0.387290	1	0
NT5C1A	84618	broad.mit.edu	37	1	40131284	40131284	+	Nonsense_Mutation	SNP	G	G	T	rs140346943		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:40131284G>T	ENST00000235628.1	-	3	341	c.342C>A	c.(340-342)taC>taA	p.Y114*		NM_032526.1	NP_115915.1	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	114					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			breast(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)	15	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CACTATCAGGGTACAGCTCCC	0.562000													6	23					3.59834e-05	4.15704e-05	0.217242	1	0
PKD1L1	168507	broad.mit.edu	37	7	47944064	47944064	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:47944064G>C	ENST00000289672.2	-	12	1892	c.1842C>G	c.(1840-1842)atC>atG	p.I614M		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	614	PKD 2.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGCCGAAGTTGATCCAGCACT	0.572000													8	51					0	0	0.335167	0	0
OR5M9	390162	broad.mit.edu	37	11	56230147	56230147	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:56230147G>A	ENST00000279791.1	-	1	730	c.731C>T	c.(730-732)aCg>aTg	p.T244M		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T244M(3)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					AGAAACAGCCGTCAAGTGGGA	0.532000													3	18					0	0	0.115264	0	0
DIDO1	11083	broad.mit.edu	37	20	61513452	61513452	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:61513452G>A	ENST00000266070.4	-	16	4181	c.3856C>T	c.(3856-3858)Cca>Tca	p.P1286S	DIDO1_ENST00000395343.1_Missense_Mutation_p.P1286S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1286	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GCTGTGGCTGGGCTGGGGGCT	0.637000													9	83					0	0	0.387290	0	0
SFI1	9814	broad.mit.edu	37	22	31985511	31985511	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:31985511C>A	ENST00000432498.1	+	14	1792	c.1399C>A	c.(1399-1401)Cga>Aga	p.R467R	SFI1_ENST00000443326.1_Silent_p.R416R|SFI1_ENST00000443011.1_Silent_p.R345R|SFI1_ENST00000540643.1_Silent_p.R443R|SFI1_ENST00000414585.1_Silent_p.R345R|SFI1_ENST00000400288.2_Silent_p.R498R|SFI1_ENST00000400289.1_Silent_p.R416R	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	498					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						CAGACTCTGGCGATGGCGCCA	0.522000													17	50					3.32936e-07	4.21225e-07	0.539581	1	0
OLIG3	167826	broad.mit.edu	37	6	137814988	137814988	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr6:137814988C>T	ENST00000367734.2	-	1	543	c.320G>A	c.(319-321)cGc>cAc	p.R107H		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	107	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		CATGACTTCGCGCAGCCCGTC	0.607000													23	67					0	0	0.624587	0	0
SOS1	6654	broad.mit.edu	37	2	39249965	39249965	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:39249965T>C	ENST00000426016.1	-	11	1690	c.1604A>G	c.(1603-1605)aAc>aGc	p.N535S	SOS1_ENST00000402219.2_Missense_Mutation_p.N535S|SOS1_ENST00000395038.2_Missense_Mutation_p.N535S			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	535	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				CATCCAATTGTTTTTCTCTTC	0.358000									Noonan syndrome				46	51					0	0	0.870114	0	0
NPC1L1	29881	broad.mit.edu	37	7	44571748	44571748	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:44571748C>A	ENST00000289547.4	-	9	2533	c.2478G>T	c.(2476-2478)ggG>ggT	p.G826G	NPC1L1_ENST00000381160.3_Silent_p.G826G|NPC1L1_ENST00000546276.1_Silent_p.G826G	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	826					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	CAAGCAGGAGCCCCTCTCCCT	0.642000													30	42					2.80507e-11	4.02103e-11	0.760397	1	0
KCNA5	3741	broad.mit.edu	37	12	5154224	5154224	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:5154224T>A	ENST00000252321.3	+	1	1140	c.911T>A	c.(910-912)aTg>aAg	p.M304K		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	304						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						AGCGGGGTCATGGCCCCGCCC	0.706000													13	38					0	0	0.435327	0	0
PABPN1	8106	broad.mit.edu	37	14	23794470	23794470	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr14:23794470C>G	ENST00000216727.4	+	7	1077	c.896C>G	c.(895-897)gCg>gGg	p.A299G	PABPN1_ENST00000556821.1_Missense_Mutation_p.A171G|BCL2L2-PABPN1_ENST00000557008.1_Missense_Mutation_p.A326G|PABPN1_ENST00000397276.2_3'UTR|BCL2L2-PABPN1_ENST00000553781.1_Missense_Mutation_p.A326G	NM_004643.3	NP_004634.1			poly(A) binding protein, nuclear 1											large_intestine(1)|lung(1)|ovary(2)	4	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CGGGCTAGAGCGACATCATGG	0.423000													61	66					0	0	0.870114	0	0
FAM227B	196951	broad.mit.edu	37	15	49903438	49903438	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr15:49903438C>A	ENST00000299338.6	-	3	382	c.79G>T	c.(79-81)Gaa>Taa	p.E27*	FAM227B_ENST00000561064.1_Nonsense_Mutation_p.E27*|FAM227B_ENST00000560246.1_Nonsense_Mutation_p.E27*|FAM227B_ENST00000558594.1_Nonsense_Mutation_p.E27*|FAM227B_ENST00000558862.1_5'UTR	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		AAGAATTCTTCAATGCTCTTT	0.279000													6	25					0.217242	0.221134	0.217242	1	0
KLK8	11202	broad.mit.edu	37	19	51503889	51503889	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:51503889G>A	ENST00000391806.2	-	3	236	c.156C>T	c.(154-156)ccC>ccT	p.P52P	KLK8_ENST00000600767.1_Intron|KLK8_ENST00000291726.7_Intron|KLK8_ENST00000347619.4_Intron|CTB-147C22.9_ENST00000594512.1_RNA|KLK8_ENST00000593490.1_Intron|KLK9_ENST00000376832.4_Intron|KLK8_ENST00000320838.5_Intron|KLK9_ENST00000250366.6_Intron			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	23	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GGCAGTGCGAGGGCTGGGAAG	0.622000													18	42					0	0	0.520397	0	0
FBN2	2201	broad.mit.edu	37	5	127730897	127730897	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:127730897C>T	ENST00000508053.1	-	15	2123	c.1149G>A	c.(1147-1149)atG>atA	p.M383I	FBN2_ENST00000262464.4_Missense_Mutation_p.M383I|FBN2_ENST00000508989.1_Missense_Mutation_p.M350I			P35556	FBN2_HUMAN	fibrillin 2	383	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCATTTTCGTCATTCTCCCCG	0.537000													7	22					0	0	0.307466	0	0
RHPN2	85415	broad.mit.edu	37	19	33471061	33471061	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr19:33471061G>C	ENST00000254260.3	-	15	1937	c.1902C>G	c.(1900-1902)atC>atG	p.I634M	RHPN2_ENST00000400226.4_Missense_Mutation_p.I483M|RHPN2_ENST00000588683.1_5'UTR	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	634					signal transduction	perinuclear region of cytoplasm	protein binding	p.I634I(1)		NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					GCTTCTTGGAGATTTTCTTGG	0.493000													19	87					0	0	0.592651	0	0
RASGRF2	5924	broad.mit.edu	37	5	80511762	80511762	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr5:80511762A>G	ENST00000265080.4	+	24	3489	c.3422A>G	c.(3421-3423)gAa>gGa	p.E1141G	CTC-281B15.1_ENST00000503483.2_RNA|CTC-281B15.1_ENST00000511495.1_RNA	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	1141	Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AATCTTAGAGAAACCCTTAAA	0.264000													6	17					0	0	0.217242	0	0
GCC2	9648	broad.mit.edu	37	2	109088072	109088072	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:109088072C>G	ENST00000309863.6	+	6	3001	c.2287C>G	c.(2287-2289)Ctt>Gtt	p.L763V		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	763					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						GTATGGTTTTCTTAAAGAAAT	0.338000													13	60					0	0	0.411799	0	0
LANCL2	55915	broad.mit.edu	37	7	55466259	55466259	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:55466259G>T	ENST00000254770.2	+	3	1044	c.466G>T	c.(466-468)Gct>Tct	p.A156S	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	156					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TGGCCCCCTGGCTGTTGGAGC	0.488000													4	31					1.23904e-05	1.45291e-05	0.184627	1	0
ZNF638	27332	broad.mit.edu	37	2	71591219	71591219	+	Silent	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:71591219G>C	ENST00000409544.1	+	5	2184	c.1554G>C	c.(1552-1554)ccG>ccC	p.P518P	ZNF638_ENST00000355812.3_Silent_p.P518P|ZNF638_ENST00000264447.4_Silent_p.P518P|ZNF638_ENST00000377802.2_Silent_p.P518P|ZNF638_ENST00000410075.1_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	518	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TGTATAGGCCGAGAAGTCGAA	0.448000													27	41					0	0	0.681144	0	0
NAGLU	4669	broad.mit.edu	37	17	40690472	40690472	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:40690472C>T	ENST00000225927.2	+	3	748	c.647C>T	c.(646-648)cCc>cTc	p.P216L	RP11-400F19.8_ENST00000585572.1_RNA	NM_000263.3	NP_000254.2	P54802	ANAG_HUMAN	N-acetylglucosaminidase, alpha	216						lysosome	alpha-N-acetylglucosaminidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(1)|ovary(2)|skin(1)	12		all_cancers(22;1.58e-05)|Breast(137;0.000153)|all_epithelial(22;0.000344)		BRCA - Breast invasive adenocarcinoma(366;0.13)	N-Acetyl-D-glucosamine(DB00141)	CCCCTGCCCCCCTCCTGGCAC	0.582000													10	119					0	0	0.361761	0	0
METTL18	92342	broad.mit.edu	37	1	169762232	169762232	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:169762232C>G	ENST00000310392.4	-	2	958	c.605G>C	c.(604-606)gGt>gCt	p.G202A	C1orf112_ENST00000498289.1_Intron|METTL18_ENST00000303469.2_Missense_Mutation_p.G202A	NM_033418.2	NP_219486.1	O95568	MET18_HUMAN	methyltransferase like 18	202						cytoplasm	protein methyltransferase activity			kidney(1)|large_intestine(3)|lung(4)	8						TGCAGTTATACCTAGTAAACC	0.393000													20	147					0	0	0.624587	0	0
TMX3	54495	broad.mit.edu	37	18	66365215	66365215	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:66365215C>G	ENST00000299608.2	-	7	762	c.446G>C	c.(445-447)aGa>aCa	p.R149T	TMX3_ENST00000443099.2_Missense_Mutation_p.R122T|TMX3_ENST00000562706.1_Missense_Mutation_p.R149T	NM_019022.3	NP_061895.3	Q96JJ7	TMX3_HUMAN	thioredoxin-related transmembrane protein 3	149					cell redox homeostasis|glycerol ether metabolic process	endoplasmic reticulum membrane|integral to membrane	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	17						TACACGGTGTCTCTTCTGCAT	0.318000													7	12					0	0	0.307466	0	0
KEAP1	9817	broad.mit.edu	37	19	10597495	10597495	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:10597495C>A	ENST00000171111.5	-	6	2256		c.e6-1		KEAP1_ENST00000393623.2_Splice_Site	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1						regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TCATAGCCTCCTGCGGGAAGA	0.567000													28	18					2.79863e-10	3.84812e-10	0.681144	1	0
NKAPL	222698	broad.mit.edu	37	6	28227392	28227392	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:28227392C>T	ENST00000343684.3	+	1	295	c.243C>T	c.(241-243)taC>taT	p.Y81Y		NM_001007531.1	NP_001007532.1	Q5M9Q1	NKAPL_HUMAN	NFKB activating protein-like	81								p.Y81Y(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	31						TCCGCAACTACGCCTTCGCGT	0.587000													7	67					0	0	0.248553	0	0
CDX2	1045	broad.mit.edu	37	13	28537312	28537312	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:28537312G>T	ENST00000381020.7	-	3	3014	c.882C>A	c.(880-882)ggC>ggA	p.G294G	CDX2_ENST00000548877.1_5'UTR	NM_001265.4	NP_001256.3	Q99626	CDX2_HUMAN	caudal type homeobox 2	294					organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(6)	9	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		CAGGGACAGAGCCAGGCACTG	0.657000			T	ETV6	AML								12	17					4.3838e-07	5.4572e-07	0.435327	1	0
LAMB1	3912	broad.mit.edu	37	7	107599871	107599871	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:107599871C>A	ENST00000393561.1	-	18	2769	c.2585G>T	c.(2584-2586)gGc>gTc	p.G862V	LAMB1_ENST00000222399.6_Missense_Mutation_p.G838V			P07942	LAMB1_HUMAN	laminin, beta 1	838	Laminin EGF-like 7.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGGCACTGGCCAGTGACGGG	0.532000													24	22					9.57634e-11	1.33188e-10	0.654019	1	0
A1CF	29974	broad.mit.edu	37	10	52575818	52575818	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:52575818G>T	ENST00000395489.2	-	11	1464	c.1068C>A	c.(1066-1068)gcC>gcA	p.A356A	A1CF_ENST00000395495.1_Silent_p.A308A|A1CF_ENST00000373997.3_Silent_p.A363A|A1CF_ENST00000373995.3_Silent_p.A371A|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000373993.1_Silent_p.A363A|A1CF_ENST00000282641.2_Silent_p.A363A|ASAH2B_ENST00000483649.1_3'UTR|A1CF_ENST00000374001.1_Silent_p.A363A	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	363					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GTCCTTTGGTGGCTGGGAAAT	0.483000													34	78					7.04047e-22	1.21008e-21	0.812448	1	0
IPMK	253430	broad.mit.edu	37	10	59956160	59956160	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:59956160C>A	ENST00000373935.3	-	6	1250	c.928G>T	c.(928-930)Gtg>Ttg	p.V310L		NM_152230.4	NP_689416.1	Q8NFU5	IPMK_HUMAN	inositol polyphosphate multikinase	310						nucleus	ATP binding|inositol trisphosphate 6-kinase activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)	22						CTTTTGCCCACTGAAGACTCT	0.373000													36	110					6.84511e-11	9.58633e-11	0.779181	1	0
SLC7A13	157724	broad.mit.edu	37	8	87226715	87226715	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:87226715G>T	ENST00000297524.3	-	4	1443	c.1340C>A	c.(1339-1341)gCt>gAt	p.A447D	SLC7A13_ENST00000419776.2_3'UTR	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	447						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						CTCAAACCAAGCCAATCTTAT	0.333000													18	16					2.39187e-15	3.76845e-15	0.575678	1	0
PTPRJ	5795	broad.mit.edu	37	11	48186005	48186005	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:48186005G>T	ENST00000418331.2	+	24	4145	c.3793G>T	c.(3793-3795)Gtg>Ttg	p.V1265L		NM_002843.3	NP_002834.3	Q12913	PTPRJ_HUMAN	protein tyrosine phosphatase, receptor type, J	1265	Tyrosine-protein phosphatase.				contact inhibition|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of T cell receptor signaling pathway|negative regulation of vascular permeability|platelet-derived growth factor receptor signaling pathway|positive chemotaxis|positive regulation of focal adhesion assembly|positive regulation of protein kinase B signaling cascade|positive regulation of survival gene product expression	cell surface|cell-cell junction|immunological synapse|integral to plasma membrane|ruffle membrane	beta-catenin binding|delta-catenin binding|gamma-catenin binding|mitogen-activated protein kinase binding|platelet-derived growth factor receptor binding|protein tyrosine phosphatase activity			breast(3)|endometrium(7)|kidney(7)|large_intestine(5)|lung(15)|ovary(1)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TGAGAACACCGTGGATGTGTA	0.468000													21	34					3.5997e-14	5.49954e-14	0.624587	1	0
NOX4	50507	broad.mit.edu	37	11	89133461	89133461	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:89133461G>T	ENST00000535633.1	-	10	1171	c.861C>A	c.(859-861)atC>atA	p.I287I	NOX4_ENST00000413594.2_Silent_p.I332I|NOX4_ENST00000527956.1_Silent_p.I287I|NOX4_ENST00000263317.4_Silent_p.I311I|NOX4_ENST00000532825.1_Silent_p.I287I|NOX4_ENST00000531342.1_Intron|NOX4_ENST00000542487.1_Silent_p.I287I|NOX4_ENST00000375979.3_Intron|NOX4_ENST00000534731.1_Silent_p.I311I|NOX4_ENST00000424319.1_Silent_p.I287I|NOX4_ENST00000527626.1_Silent_p.I145I|NOX4_ENST00000528341.1_Silent_p.I286I|NOX4_ENST00000343727.5_Silent_p.I287I|NOX4_ENST00000525196.1_Intron	NM_001143836.1|NM_016931.3	NP_001137308.1|NP_058627.1	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	311	Ferric oxidoreductase.|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				TGACCGAAATGATGGTGACTG	0.433000													10	81					3.86212e-05	4.45063e-05	0.361761	1	0
NBPF10	100132406	broad.mit.edu	37	1	145368636	145368636	+	Silent	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:145368636G>C	ENST00000342960.5	+	84	10649	c.10614G>C	c.(10612-10614)gtG>gtC	p.V3538V	NBPF10_ENST00000369338.1_Silent_p.V654V|NBPF10_ENST00000369339.2_Silent_p.V656V	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3538										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CTTTGACGGTGACAAGTCTCC	0.468000													112	248					0	0	0.870114	0	0
ATP8A2	51761	broad.mit.edu	37	13	26116075	26116075	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:26116075G>T	ENST00000381655.2	+	9	812	c.670G>T	c.(670-672)Gac>Tac	p.D224Y	ATP8A2_ENST00000255283.8_Missense_Mutation_p.D184Y	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	184					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TCACACTGCTGACATGCAAAC	0.423000													27	29					2.24059e-21	3.80775e-21	0.706142	1	0
COL12A1	1303	broad.mit.edu	37	6	75890796	75890796	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:75890796C>A	ENST00000322507.8	-	11	2332	c.2023G>T	c.(2023-2025)Gtc>Ttc	p.V675F	COL12A1_ENST00000483888.2_Missense_Mutation_p.V675F|COL12A1_ENST00000416123.2_Missense_Mutation_p.V675F|COL12A1_ENST00000345356.6_Intron	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	675	Fibronectin type-III 3.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ACCACAGTGACCTCATCATCC	0.483000													76	26					2.14232e-31	3.85746e-31	0.870114	1	0
ZKSCAN2	342357	broad.mit.edu	37	16	25258513	25258513	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:25258513T>C	ENST00000328086.7	-	5	1807	c.1004A>G	c.(1003-1005)gAt>gGt	p.D335G		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	335					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		TATCTTTTCATCTTCTAAACC	0.463000													12	87					0	0	0.387290	0	0
TXLNB	167838	broad.mit.edu	37	6	139583811	139583811	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:139583811G>T	ENST00000358430.3	-	5	1019	c.787C>A	c.(787-789)Cag>Aag	p.Q263K		NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	263						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		TCACTCTGCTGCTCGATCTGG	0.512000													24	92					1.77063e-15	2.80427e-15	0.693898	1	0
IGHMBP2	3508	broad.mit.edu	37	11	68703722	68703722	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:68703722G>T	ENST00000255078.3	+	13	1885	c.1774G>T	c.(1774-1776)Gct>Tct	p.A592S	IGHMBP2_ENST00000541229.1_3'UTR	NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	592					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			TGGTTTTCTTGCTGAGGACCG	0.532000													26	82					1.55469e-16	2.52169e-16	0.654019	1	0
GRID2	2895	broad.mit.edu	37	4	94316766	94316766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:94316766C>A	ENST00000282020.4	+	9	1512	c.1254C>A	c.(1252-1254)tgC>tgA	p.C418*	GRID2_ENST00000510992.1_Nonsense_Mutation_p.C323*	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	418					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AGCTTGGTTGCTGGAATCCTG	0.423000													24	25					1.77063e-15	2.80427e-15	0.693898	1	0
BIRC8	112401	broad.mit.edu	37	19	53793012	53793012	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:53793012G>A	ENST00000426466.1	-	1	1863	c.616C>T	c.(616-618)Cat>Tat	p.H206Y		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	206					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		GTGACCAGATGTCCACAAGGA	0.423000													15	76					0	0	0.520397	0	0
GOLGA4	2803	broad.mit.edu	37	3	37366780	37366780	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:37366780C>T	ENST00000361924.2	+	14	3777	c.3403C>T	c.(3403-3405)Cat>Tat	p.H1135Y	GOLGA4_ENST00000356847.4_Missense_Mutation_p.H1157Y|GOLGA4_ENST00000444882.1_Intron	NM_002078.4	NP_002069.2	Q13439	GOGA4_HUMAN	golgin A4	1135	Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			NS(2)|breast(3)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(17)|liver(2)|lung(16)|ovary(4)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						ACTGAAAGCTCATCTTGAAAA	0.368000													27	20					0	0	0.693898	0	0
ANKRD20A11P	391267	broad.mit.edu	37	21	15323433	15323433	+	RNA	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr21:15323433C>T	ENST00000344693.5	-	0	877					NR_027270.1																						GCTCCTTTCACAGCAGGATCT	0.323000													3	36					0	0	0.248553	0	0
YIF1B	90522	broad.mit.edu	37	19	38798252	38798252	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:38798252C>A	ENST00000392124.3	-	5	901	c.587G>T	c.(586-588)gGc>gTc	p.G196V	YIF1B_ENST00000591755.1_Missense_Mutation_p.G224V|YIF1B_ENST00000592694.1_Missense_Mutation_p.G196V|YIF1B_ENST00000329420.8_Missense_Mutation_p.G212V|YIF1B_ENST00000337679.8_Missense_Mutation_p.G224V|YIF1B_ENST00000591784.1_Missense_Mutation_p.G196V|YIF1B_ENST00000592246.1_Missense_Mutation_p.G161V|YIF1B_ENST00000339413.6_Missense_Mutation_p.G227V	NM_033557.3	NP_291035.1	Q5BJH7	YIF1B_HUMAN	Yip1 interacting factor homolog B (S. cerevisiae)	227						integral to membrane				central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)	10	all_cancers(60;1.07e-06)		Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ATATTTGTAGCCCAAGAAGGC	0.627000													5	51					5.9392e-07	7.37827e-07	0.217242	1	0
DEDD2	162989	broad.mit.edu	37	19	42713942	42713942	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:42713942C>A	ENST00000595337.1	-	4	586	c.499G>T	c.(499-501)Ggt>Tgt	p.G167C	DEDD2_ENST00000596251.1_Missense_Mutation_p.G167C|DEDD2_ENST00000598727.1_Missense_Mutation_p.G167C|DEDD2_ENST00000593804.1_5'UTR|DEDD2_ENST00000336034.4_Missense_Mutation_p.G162C	NM_001270614.1	NP_001257543.1	Q8WXF8	DEDD2_HUMAN	death effector domain containing 2	167					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(2)	5		Prostate(69;0.0704)				CGTCTGGCACCACCACTGGGC	0.657000													33	23					2.80507e-11	4.00252e-11	0.760397	1	0
EVI5	7813	broad.mit.edu	37	1	92979323	92979323	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:92979323C>T	ENST00000370331.1	-	18	2332	c.2323G>A	c.(2323-2325)Ggt>Agt	p.G775S	EVI5_ENST00000540033.1_Missense_Mutation_p.G775S|EVI5_ENST00000543509.1_Missense_Mutation_p.G786S	NM_005665.4	NP_005656.4	O60447	EVI5_HUMAN	ecotropic viral integration site 5	775	Interaction with AURKB and INCENP.|Targeting to the centrosomes.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(1)|skin(1)	38		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		CTCTCACTACCATCTGCCACT	0.478000													31	47					0	0	0.760397	0	0
ANAPC1	64682	broad.mit.edu	37	2	112605391	112605391	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:112605391C>T	ENST00000341068.3	-	15	2474	c.1702G>A	c.(1702-1704)Gat>Aat	p.D568N		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	568					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						TAGAGAGAATCATGAAGTTTT	0.358000													8	86					0	0	0.278610	0	0
NAV3	89795	broad.mit.edu	37	12	78443877	78443877	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:78443877C>G	ENST00000397909.2	+	10	2301	c.2128C>G	c.(2128-2130)Cac>Gac	p.H710D	NAV3_ENST00000266692.7_Missense_Mutation_p.H710D|NAV3_ENST00000228327.6_Missense_Mutation_p.H710D|NAV3_ENST00000536525.2_Missense_Mutation_p.H710D			Q8IVL0	NAV3_HUMAN	neuron navigator 3	710						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						TCAGATAAGCCACAGGTTTTT	0.333000										HNSCC(70;0.22)			12	23					0	0	0.411799	0	0
ASAH2	56624	broad.mit.edu	37	10	52008320	52008320	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:52008320A>T	ENST00000395526.3	-	1	50	c.51T>A	c.(49-51)ctT>ctA	p.L17L	ASAH2_ENST00000447815.1_Silent_p.L17L	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	17					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(1)|lung(9)|urinary_tract(1)	11						TCATCATTACAAGGAGGAAAA	0.453000													5	54					0	0	0.217242	0	0
DPT	1805	broad.mit.edu	37	1	168670315	168670315	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:168670315A>G	ENST00000367817.3	-	3	568	c.479T>C	c.(478-480)aTt>aCt	p.I160T		NM_001937.4	NP_001928.2	Q07507	DERM_HUMAN	dermatopontin	160	2 X 53-55 AA tandem repeats.|3 X 6 AA repeats of D-R-[EQ]-W-[NQK]- [FY].				cell adhesion	extracellular space|proteinaceous extracellular matrix				kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)	12	all_hematologic(923;0.208)					ATTGTAGGAAATCATGTCCAT	0.418000													14	151					0	0	0.479597	0	0
C14orf159	80017	broad.mit.edu	37	14	91655475	91655475	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:91655475A>G	ENST00000518868.1	+	12	1846	c.1156A>G	c.(1156-1158)Aac>Gac	p.N386D	C14orf159_ENST00000412671.2_Missense_Mutation_p.N386D|C14orf159_ENST00000525393.2_Missense_Mutation_p.N257D|C14orf159_ENST00000523816.1_Missense_Mutation_p.N381D|C14orf159_ENST00000520328.1_Missense_Mutation_p.N369D|C14orf159_ENST00000523771.1_Missense_Mutation_p.N381D|C14orf159_ENST00000522322.1_Missense_Mutation_p.N381D|C14orf159_ENST00000256324.10_Missense_Mutation_p.N386D|C14orf159_ENST00000521077.2_Missense_Mutation_p.N386D|C14orf159_ENST00000428926.2_Missense_Mutation_p.N381D			Q7Z3D6	CN159_HUMAN	chromosome 14 open reading frame 159	381						mitochondrion				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	21		all_cancers(154;0.0191)|all_epithelial(191;0.241)		Epithelial(152;0.141)|OV - Ovarian serous cystadenocarcinoma(161;0.207)		GAGAGCCTGGAACTTGCACCA	0.547000													4	26					0	0	0.217242	0	0
ST3GAL1	6482	broad.mit.edu	37	8	134472055	134472055	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:134472055C>A	ENST00000319914.5	-	9	2002	c.975G>T	c.(973-975)acG>acT	p.T325T	ST3GAL1_ENST00000521180.1_Silent_p.T325T|ST3GAL1_ENST00000522652.1_Silent_p.T325T|ST3GAL1_ENST00000399640.2_Silent_p.T325T			Q11201	SIA4A_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	325					protein glycosylation	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(3)|large_intestine(2)|lung(11)|prostate(1)	17	all_epithelial(106;1.53e-23)|Lung NSC(106;3.15e-07)|all_lung(105;1.26e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.00721)			CCAAGGTGGCCGTCACGTTAG	0.562000													166	54					2.62042e-76	4.87802e-76	0.870114	1	0
CACNA1I	8911	broad.mit.edu	37	22	40078529	40078529	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:40078529G>T	ENST00000336649.4	+	38	5711	c.5711G>T	c.(5710-5712)cGt>cTt	p.R1904L	CACNA1I_ENST00000407673.1_Missense_Mutation_p.R1863L|CACNA1I_ENST00000404898.1_Missense_Mutation_p.R1863L|CACNA1I_ENST00000400164.3_Missense_Mutation_p.R1863L|CACNA1I_ENST00000402142.3_Missense_Mutation_p.R1898L|CACNA1I_ENST00000401624.1_Missense_Mutation_p.R1898L			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1898					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GAGCCCATGCGTGTGGGAGAC	0.592000													18	70					9.95505e-16	1.59756e-15	0.624587	1	0
C16orf3	750	broad.mit.edu	37	16	90095616	90095616	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:90095616G>T	ENST00000408886.2	-	1	693	c.135C>A	c.(133-135)gcC>gcA	p.A45A	GAS8_ENST00000536122.1_Intron|GAS8_ENST00000540721.1_Intron|GAS8_ENST00000268699.4_Intron	NM_001214.3	NP_001205.3	O95177	CP003_HUMAN	chromosome 16 open reading frame 3	45										large_intestine(1)|lung(2)|prostate(1)	4		all_cancers(9;9.01e-08)|Hepatocellular(780;0.000325)|Lung NSC(15;0.0104)|all_lung(18;0.0239)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		ctacggggcaggctacggggc	0.672000													6	15					8.12818e-05	9.22618e-05	0.248553	1	0
ATP2B2	491	broad.mit.edu	37	3	10392234	10392234	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:10392234G>T	ENST00000397077.1	-	14	2604	c.2029C>A	c.(2029-2031)Cgg>Agg	p.R677R	ATP2B2_ENST00000352432.4_Silent_p.R722R|ATP2B2_ENST00000383800.4_Silent_p.R677R|ATP2B2_ENST00000360273.2_Silent_p.R722R|ATP2B2_ENST00000343816.4_Silent_p.R708R			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	722					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						ATGCCTGCCCGCTGGCACTTG	0.632000													6	35					0.217242	0.221265	0.217242	1	0
ARHGEF10	9639	broad.mit.edu	37	8	1877563	1877563	+	Silent	SNP	C	C	T	rs144293528		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:1877563C>T	ENST00000518288.1	+	26	3268	c.3105C>T	c.(3103-3105)taC>taT	p.Y1035Y	ARHGEF10_ENST00000520359.1_Silent_p.Y973Y|ARHGEF10_ENST00000262112.6_Silent_p.Y1007Y|ARHGEF10_ENST00000398564.1_Silent_p.Y1036Y|ARHGEF10_ENST00000349830.3_Silent_p.Y1011Y			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	1036					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		AGAGCCTGTACGCTGGCCTGG	0.592000													6	63					0	0	0.217242	0	0
EDIL3	10085	broad.mit.edu	37	5	83549941	83549941	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:83549941C>A	ENST00000296591.5	-	2	575	c.157G>T	c.(157-159)Ggc>Tgc	p.G53C	EDIL3_ENST00000380138.3_Missense_Mutation_p.G53C	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	53	EGF-like 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TCTGTGAAGCCATCTGGACAC	0.398000													11	29					5.50884e-06	6.53499e-06	0.411799	1	0
TSPEAR	54084	broad.mit.edu	37	21	45948417	45948417	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr21:45948417C>T	ENST00000323084.4	-	6	905	c.840G>A	c.(838-840)gtG>gtA	p.V280V	TSPEAR_ENST00000397916.1_Silent_p.V212V	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	280					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						GGGCGTCTTCCACCTCGGTAC	0.592000													19	48					0	0	0.539581	0	0
HK2	3099	broad.mit.edu	37	2	75113632	75113632	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:75113632C>T	ENST00000290573.2	+	15	2651	c.2051C>T	c.(2050-2052)gCc>gTc	p.A684V	HK2_ENST00000409174.1_Missense_Mutation_p.A656V	NM_000189.4	NP_000180.2	P52789	HXK2_HUMAN	hexokinase 2	684	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(22)|ovary(2)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	43						GGCAGCAATGCCTGCTACATG	0.592000													14	56					0	0	0.457914	0	0
NAV3	89795	broad.mit.edu	37	12	78444840	78444840	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:78444840A>G	ENST00000397909.2	+	11	2602	c.2429A>G	c.(2428-2430)gAc>gGc	p.D810G	NAV3_ENST00000266692.7_Missense_Mutation_p.D810G|NAV3_ENST00000228327.6_Missense_Mutation_p.D810G|NAV3_ENST00000536525.2_Missense_Mutation_p.D810G			Q8IVL0	NAV3_HUMAN	neuron navigator 3	810						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AGTGACCTGGACATGTCTTCT	0.488000										HNSCC(70;0.22)			7	38					0	0	0.248553	0	0
OOSP2	219990	broad.mit.edu	37	11	59812143	59812143	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:59812143G>T	ENST00000278855.2	+	3	428		c.e3-1		PLAC1L_ENST00000532905.1_Splice_Site	NM_173801.3	NP_776162.2	Q86WS3	PLACL_HUMAN								extracellular region				breast(1)|lung(9)|ovary(2)|prostate(2)|skin(1)	15						TGCTCTCCTAGGTAGTTTCTG	0.393000													29	26					9.39395e-14	1.4244e-13	0.706142	1	0
OR4N4	283694	broad.mit.edu	37	15	22382684	22382684	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:22382684C>A	ENST00000328795.4	+	1	303	c.212C>A	c.(211-213)gCa>gAa	p.A71E	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTCCTGGATGCATCCTACTCC	0.478000													28	222					5.44703e-19	9.12868e-19	0.847076	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319715	21319715	+	Missense_Mutation	SNP	C	C	A	rs140886918	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:21319715C>A	ENST00000583088.1	+	3	1956	c.1061C>A	c.(1060-1062)aCg>aAg	p.T354K	KCNJ12_ENST00000331718.5_Missense_Mutation_p.T354K	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.T354M(1)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GTGCCCTCTACGCCCCGCTGC	0.572000										Prostate(3;0.18)			22	110					2.89027e-11	4.11438e-11	0.624587	1	0
NEU4	129807	broad.mit.edu	37	2	242758149	242758149	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:242758149G>T	ENST00000391969.2	+	5	1941	c.1230G>T	c.(1228-1230)tgG>tgT	p.W410C	NEU4_ENST00000407683.1_Missense_Mutation_p.W410C|NEU4_ENST00000405370.1_Missense_Mutation_p.W410C|NEU4_ENST00000404257.1_Missense_Mutation_p.W422C|NEU4_ENST00000325935.6_Missense_Mutation_p.W423C	NM_001167602.1	NP_001161074.1	Q8WWR8	NEUR4_HUMAN	sialidase 4	410						lysosomal lumen|organelle inner membrane	exo-alpha-sialidase activity|protein binding			breast(1)|lung(10)|prostate(2)|skin(2)	15		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0825)		CAGAGCCCTGGGTGATCTACG	0.697000													4	6					0.00024832	0.000276165	0.150653	1	0
ANKRD34A	284615	broad.mit.edu	37	1	145474248	145474248	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:145474248G>T	ENST00000323397.4	+	4	2213	c.920G>T	c.(919-921)aGc>aTc	p.S307I		NM_001039888.2	NP_001034977.1	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34A	307	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	20	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					AAAGTGACTAGCGGGGGTCCT	0.632000													18	36					1.99824e-07	2.55049e-07	0.520397	1	0
MIR134	406924	broad.mit.edu	37	14	101521083	101521083	+	RNA	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:101521083A>T	ENST00000385258.2	+	0	76					NR_029698.1																						TGGGCCACCTAGTCACCAACC	0.587000													3	29					0	0	0.115264	0	0
GTDC1	79712	broad.mit.edu	37	2	144966278	144966278	+	Missense_Mutation	SNP	T	T	A	rs114787738	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:144966278T>A	ENST00000409214.1	-	4	349	c.71A>T	c.(70-72)gAg>gTg	p.E24V	GTDC1_ENST00000463875.2_Intron|GTDC1_ENST00000392869.1_Missense_Mutation_p.E24V|GTDC1_ENST00000542155.1_Missense_Mutation_p.E24V|GTDC1_ENST00000409298.1_Missense_Mutation_p.E24V|GTDC1_ENST00000392867.3_Missense_Mutation_p.E24V|GTDC1_ENST00000241391.5_Missense_Mutation_p.E24V|GTDC1_ENST00000344850.4_Missense_Mutation_p.E24V	NM_001006636.3	NP_001006637.1	Q4AE62	GTDC1_HUMAN	glycosyltransferase-like domain containing 1	24					biosynthetic process		transferase activity, transferring glycosyl groups			central_nervous_system(1)|endometrium(1)|large_intestine(4)|liver(1)|lung(17)|ovary(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.0914)		GTCTCCTAACTCTTCTTGAAG	0.438000													8	79					0	0	0.335167	0	0
DSTYK	25778	broad.mit.edu	37	1	205131163	205131163	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:205131163C>A	ENST00000367162.3	-	6	1849		c.e6+1		DSTYK_ENST00000367161.3_Splice_Site|DSTYK_ENST00000367160.4_Intron	NM_015375.2	NP_056190.1	Q6XUX3	DUSTY_HUMAN	dual serine/threonine and tyrosine protein kinase							cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)	14						TACATACCAACCTGCCGCAAG	0.498000													4	21					0.150653	0.154746	0.150653	1	0
PHLDB2	90102	broad.mit.edu	37	3	111681059	111681059	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:111681059G>T	ENST00000431670.2	+	13	3388	c.2977G>T	c.(2977-2979)Gat>Tat	p.D993Y	PHLDB2_ENST00000470699.2_3'UTR|PHLDB2_ENST00000412622.1_Missense_Mutation_p.D950Y|PHLDB2_ENST00000495180.1_Missense_Mutation_p.D484Y|PHLDB2_ENST00000481953.1_Missense_Mutation_p.D950Y|PHLDB2_ENST00000393923.3_Missense_Mutation_p.D977Y|PHLDB2_ENST00000393925.3_Missense_Mutation_p.D993Y	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	993						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						CCATTATCCAGATCACAGCTA	0.438000													14	78					4.3838e-07	5.4572e-07	0.435327	1	0
ZNF221	7638	broad.mit.edu	37	19	44471441	44471441	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:44471441A>C	ENST00000251269.5	+	6	2115	c.1787A>C	c.(1786-1788)gAa>gCa	p.E596A	ZNF221_ENST00000592350.1_Missense_Mutation_p.E596A|ZNF221_ENST00000587682.1_Missense_Mutation_p.E596A	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	596					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				GGAGTGTGGGAAGAGATCTAC	0.433000													10	113					0	0	0.361761	0	0
DHX34	9704	broad.mit.edu	37	19	47876924	47876924	+	Silent	SNP	G	G	T	rs147516349		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:47876924G>T	ENST00000328771.4	+	9	2380	c.2031G>T	c.(2029-2031)ctG>ctT	p.L677L		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	677						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		AGCATCGACTGTACGAAATGG	0.617000													11	12					2.27111e-07	2.87452e-07	0.411799	1	0
GRIK4	2900	broad.mit.edu	37	11	120769328	120769328	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:120769328C>G	ENST00000527524.2	+	12	1539	c.1252C>G	c.(1252-1254)Ctg>Gtg	p.L418V	GRIK4_ENST00000438375.2_Missense_Mutation_p.L418V			Q16099	GRIK4_HUMAN	glutamate receptor, ionotropic, kainate 4	418					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(20)|liver(1)|lung(29)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	69		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CAACACCACCCTGGTCGTCAC	0.622000													5	15					0	0	0.248553	0	0
CACNG5	27091	broad.mit.edu	37	17	64881046	64881046	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:64881046G>T	ENST00000169565.3	+	4	838	c.838G>T	c.(838-840)Gag>Tag	p.E280*	CACNG5_ENST00000533854.1_Intron|CACNG5_ENST00000307139.3_Intron			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	0					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CCAGCCAAGGGAGATGAGGCA	0.632000													10	41					2.80697e-09	3.76545e-09	0.387290	1	0
AGXT2	64902	broad.mit.edu	37	5	34998832	34998832	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:34998832C>A	ENST00000231420.6	-	14	1737	c.1537G>T	c.(1537-1539)Gct>Tct	p.A513S		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	513					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	TGTTACTTAGCTCTTCTTTCC	0.388000													4	53					0.014758	0.015528	0.184627	1	0
CLIC2	1193	broad.mit.edu	37	X	154508586	154508586	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:154508586C>T	ENST00000369449.2	-	5	652	c.434G>A	c.(433-435)cGt>cAt	p.R145H	CLIC2_ENST00000465553.1_5'UTR	NM_001289.4	NP_001280.3	O15247	CLIC2_HUMAN	chloride intracellular channel 2	145	C-terminal.|GST C-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	voltage-gated chloride channel activity	p.R145H(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	18	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GTCATCCAGACGCTTGAATTC	0.383000													5	53					0	0	0.184627	0	0
MUC5B	727897	broad.mit.edu	37	11	1256632	1256632	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:1256632C>A	ENST00000447027.1	+	23	2936	c.2878C>A	c.(2878-2880)Ctc>Atc	p.L960I	MUC5B_ENST00000529681.1_Missense_Mutation_p.L957I			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	957	VWFD 3.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GGCCATCAAGCTCTTCGTGGA	0.647000													6	8					0.00116845	0.00126914	0.217242	1	0
PZP	5858	broad.mit.edu	37	12	9349607	9349607	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:9349607C>A	ENST00000261336.2	-	8	896		c.e8+1		PZP_ENST00000381997.2_Splice_Site	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						CGCCTACTAACCTGTTGACTG	0.453000													13	99					0.000219431	0.000246758	0.457914	1	0
PHF20L1	51105	broad.mit.edu	37	8	133855063	133855063	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:133855063C>A	ENST00000395386.2	+	19	2990	c.2691C>A	c.(2689-2691)caC>caA	p.H897Q	AF230666.2_ENST00000429151.1_RNA|PHF20L1_ENST00000220847.7_Missense_Mutation_p.H284Q|PHF20L1_ENST00000395390.2_Missense_Mutation_p.H872Q	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	897							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			AAGAATTCCACATGAGAAGTA	0.378000													113	39					3.3835e-51	6.2792e-51	0.870114	1	0
OR2L8	391190	broad.mit.edu	37	1	248112883	248112883	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:248112883A>T	ENST00000357191.3	+	1	724	c.724A>T	c.(724-726)Acc>Tcc	p.T242S	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GACCTGCAGCACCCACCTCAC	0.463000													34	132					0	0	0.760397	0	0
XIRP2	129446	broad.mit.edu	37	2	168114371	168114371	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:168114371G>T	ENST00000409728.1	+	11	1503	c.1414G>T	c.(1414-1416)Gga>Tga	p.G472*	XIRP2_ENST00000409605.1_Nonsense_Mutation_p.G217*|XIRP2_ENST00000420519.1_Nonsense_Mutation_p.G472*|XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000409756.2_Nonsense_Mutation_p.G439*|XIRP2_ENST00000409043.1_Nonsense_Mutation_p.G439*|XIRP2_ENST00000409195.1_3'UTR	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						TGGCAGTTTGGGAAATTATGC	0.318000													8	48					0.0477658	0.0497389	0.307466	1	0
RYR2	6262	broad.mit.edu	37	1	237730043	237730043	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:237730043G>T	ENST00000366574.2	+	28	3708	c.3391G>T	c.(3391-3393)Gat>Tat	p.D1131Y	RYR2_ENST00000360064.6_Missense_Mutation_p.D1129Y|RYR2_ENST00000542537.1_Missense_Mutation_p.D1115Y	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1131	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCTTGGCTCAGATGAACGTGC	0.537000													30	177					1.74807e-11	2.51805e-11	0.750413	1	0
AGPAT1	10554	broad.mit.edu	37	6	32137057	32137057	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:32137057C>A	ENST00000395499.1	-	7	1427	c.848G>T	c.(847-849)gGg>gTg	p.G283V	AGPAT1_ENST00000490711.1_5'UTR|AGPAT1_ENST00000412465.2_Missense_Mutation_p.G171V|AGPAT1_ENST00000395496.1_Missense_Mutation_p.G283V|AGPAT1_ENST00000336984.6_Missense_Mutation_p.G283V|AGPAT1_ENST00000375107.3_Missense_Mutation_p.G283V|AGPAT1_ENST00000395497.1_Missense_Mutation_p.G283V|AGPAT1_ENST00000375104.2_Missense_Mutation_p.G283V|PPT2-EGFL8_ENST00000422437.1_Intron			Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	283					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)|large_intestine(3)|lung(6)|ovary(2)	12						CAGGGTTCACCCACCGCCCCC	0.612000													15	44					1.3612e-06	1.65367e-06	0.479597	1	0
EWSR1	2130	broad.mit.edu	37	22	29695615	29695615	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:29695615G>T	ENST00000397938.2	+	16	2024	c.1705G>T	c.(1705-1707)Ggt>Tgt	p.G569C	EWSR1_ENST00000332035.6_Missense_Mutation_p.G513C|EWSR1_ENST00000331029.7_Missense_Mutation_p.G531C|EWSR1_ENST00000406548.1_Missense_Mutation_p.G568C|EWSR1_ENST00000332050.6_Missense_Mutation_p.G496C|EWSR1_ENST00000414183.2_Missense_Mutation_p.G574C	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	569	Arg/Gly/Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGGTGGCCCTGGTGGCATGCG	0.622000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								6	22					0.00198382	0.00213941	0.248553	1	0
KIRREL2	84063	broad.mit.edu	37	19	36357308	36357308	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:36357308C>A	ENST00000360202.5	+	15	2239	c.2041C>A	c.(2041-2043)Ccc>Acc	p.P681T	KIRREL2_ENST00000586102.2_Missense_Mutation_p.P661T|KIRREL2_ENST00000347900.6_Intron|KIRREL2_ENST00000262625.7_Intron|NPHS1_ENST00000591817.1_Intron|KIRREL2_ENST00000592409.1_Missense_Mutation_p.P646T	NM_032123.5|NM_199180.2	NP_115499.4|NP_954649.2	Q6UWL6	KIRR2_HUMAN	kin of IRRE like 2 (Drosophila)	681	Pro-rich.				cell adhesion	integral to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	48	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATCCTTTGGGCCCCCAGATCT	0.607000													46	128					2.24722e-20	3.79768e-20	0.870114	1	0
ASAP1	50807	broad.mit.edu	37	8	131092212	131092212	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:131092212C>A	ENST00000357668.1	-	25	2605	c.2578G>T	c.(2578-2580)Gat>Tat	p.D860Y	ASAP1_ENST00000518721.1_Missense_Mutation_p.D860Y			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	860	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						GGACCCCCATCGTTACCTACA	0.468000													13	198					0.00136819	0.00148344	0.411799	1	0
PCDH15	65217	broad.mit.edu	37	10	55912886	55912886	+	Silent	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:55912886C>G	ENST00000373965.2	-	15	2173	c.1779G>C	c.(1777-1779)gcG>gcC	p.A593A	PCDH15_ENST00000373957.3_Silent_p.A564A|PCDH15_ENST00000320301.6_Silent_p.A586A|PCDH15_ENST00000395445.1_Silent_p.A593A|PCDH15_ENST00000361849.3_Silent_p.A586A|PCDH15_ENST00000395438.1_Silent_p.A586A|PCDH15_ENST00000373955.1_Silent_p.A586A|PCDH15_ENST00000409834.1_Silent_p.A197A|PCDH15_ENST00000395430.1_Silent_p.A586A|PCDH15_ENST00000414778.1_Silent_p.A591A|PCDH15_ENST00000395433.1_Silent_p.A564A|PCDH15_ENST00000437009.1_Silent_p.A586A|PCDH15_ENST00000395432.2_Silent_p.A549A|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395446.1_Silent_p.A586A|PCDH15_ENST00000395440.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	586	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GAGCATTATCCGCTGCTTGGA	0.473000										HNSCC(58;0.16)			12	50					0	0	0.411799	0	0
MED13L	23389	broad.mit.edu	37	12	116424272	116424272	+	Silent	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:116424272C>G	ENST00000281928.3	-	19	4343	c.4137G>C	c.(4135-4137)ccG>ccC	p.P1379P		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	1379					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent			p.P1379P(1)		NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GGATGGGCAACGGCTCAGGAG	0.473000													15	27					0	0	0.457914	0	0
CD36	948	broad.mit.edu	37	7	80303324	80303324	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:80303324C>A	ENST00000435819.1	+	17	1964	c.1280C>A	c.(1279-1281)gCa>gAa	p.A427E	CD36_ENST00000309881.7_Missense_Mutation_p.A427E|CD36_ENST00000544133.1_3'UTR|CD36_ENST00000432207.1_Missense_Mutation_p.A427E|CD36_ENST00000534394.1_Missense_Mutation_p.A351E|CD36_ENST00000394788.3_Missense_Mutation_p.A427E|CD36_ENST00000433696.2_Missense_Mutation_p.A388E|CD36_ENST00000538969.1_Missense_Mutation_p.A367E|CD36_ENST00000447544.2_Missense_Mutation_p.A427E			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	427					cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						GATGAGAAGGCAAACATGTTC	0.368000													3	26					0.115264	0.119001	0.115264	1	0
HIST1H2BA	255626	broad.mit.edu	37	6	25727344	25727344	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:25727344G>A	ENST00000274764.2	+	1	208	c.208G>A	c.(208-210)Gat>Aat	p.D70N		NM_170610.2	NP_733759.1	Q96A08	H2B1A_HUMAN	histone cluster 1, H2ba	70					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)	2						CTTCGTCACTGATATCTTTGA	0.468000													12	71					0	0	0.457914	0	0
MORC1	27136	broad.mit.edu	37	3	108813842	108813842	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:108813842A>G	ENST00000232603.5	-	7	579	c.497T>C	c.(496-498)aTg>aCg	p.M166T	MORC1_ENST00000483760.1_Missense_Mutation_p.M166T	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	166					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						AGATAATTCCATTGCAAATTT	0.323000													22	8					0	0	0.608945	0	0
CTNND2	1501	broad.mit.edu	37	5	11111032	11111032	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:11111032T>A	ENST00000304623.8	-	14	2590	c.2401A>T	c.(2401-2403)Aag>Tag	p.K801*	CTNND2_ENST00000359640.2_Nonsense_Mutation_p.K801*|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000503622.1_Nonsense_Mutation_p.K464*|CTNND2_ENST00000458100.2_Nonsense_Mutation_p.K368*|CTNND2_ENST00000511377.1_Nonsense_Mutation_p.K710*	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	801					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TCAGCATCCTTGCCATTGGCC	0.562000													97	167					0	0	0.870114	0	0
MDGA1	266727	broad.mit.edu	37	6	37606412	37606412	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:37606412G>T	ENST00000434837.2	-	15	3746	c.2568C>A	c.(2566-2568)aaC>aaA	p.N856K	MDGA1_ENST00000505425.1_Missense_Mutation_p.N856K|MDGA1_ENST00000297153.7_Missense_Mutation_p.N860K	NM_153487.3	NP_705691.1	Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	856	MAM.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						GAGCCCCTTTGTTCCGGGACC	0.622000													12	17					5.16669e-11	7.26941e-11	0.387290	1	0
CHL1	10752	broad.mit.edu	37	3	382570	382570	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:382570C>G	ENST00000256509.2	+	6	1121	c.479C>G	c.(478-480)cCa>cGa	p.P160R	CHL1_ENST00000397491.2_Missense_Mutation_p.P160R	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	160	Ig-like C2-type 2.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AAAGGCCTCCCACCTTTACAC	0.398000													17	23					0	0	0.520397	0	0
LIM2	3982	broad.mit.edu	37	19	51885700	51885700	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:51885700G>T	ENST00000221973.3	-	3	465	c.423C>A	c.(421-423)ttC>ttA	p.F141L	LIM2_ENST00000596399.1_Missense_Mutation_p.F99L	NM_030657.3	NP_085915.2	P55344	LMIP_HUMAN	lens intrinsic membrane protein 2, 19kDa	99					cell-cell junction assembly	cell junction|integral to membrane	structural constituent of eye lens			endometrium(1)|large_intestine(3)|lung(2)|skin(1)	7		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.000214)|OV - Ovarian serous cystadenocarcinoma(262;0.00985)		TGCCAGCAGAGAAGGGCCGGG	0.567000													11	63					2.27111e-07	2.87452e-07	0.411799	1	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473188	22473188	+	RNA	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:22473188G>T	ENST00000557788.2	-	0	82																											CACCAGTCCTGGGCCCGACTC	0.622000													11	67					4.3838e-07	5.4572e-07	0.435327	1	0
CHEK2P2	646096	broad.mit.edu	37	15	20496752	20496752	+	RNA	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:20496752T>C	ENST00000555186.1	+	0	805					NR_038836.1																						TTTCTTTGAGTCTGTTTTTTA	0.378000													3	17					0	0	0.115264	0	0
GPR141	353345	broad.mit.edu	37	7	37780670	37780670	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:37780670G>A	ENST00000447769.1	+	4	964	c.675G>A	c.(673-675)ctG>ctA	p.L225L	EPDR1_ENST00000476620.1_Intron|GPR141_ENST00000461610.1_Intron|GPR141_ENST00000334425.1_Silent_p.L225L			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	225						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GGGCTCAGCTGAAAAACCTAT	0.428000													61	78					0	0	0.870114	0	0
OR4C16	219428	broad.mit.edu	37	11	55339908	55339908	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:55339908C>G	ENST00000314634.3	+	1	305	c.305C>G	c.(304-306)tCc>tGc	p.S102C		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				GTCTTTTCATCCCATGTCTTT	0.478000													92	117					0	0	0.870114	0	0
MON1B	22879	broad.mit.edu	37	16	77225496	77225496	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:77225496G>T	ENST00000248248.3	+	2	464	c.114G>T	c.(112-114)ccG>ccT	p.P38P	MON1B_ENST00000439557.2_Silent_p.P38P|MON1B_ENST00000320859.6_Silent_p.P38P|MON1B_ENST00000545553.1_Intron	NM_014940.2	NP_055755.1	Q7L1V2	MON1B_HUMAN	MON1 secretory trafficking family member B	38							protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	17						ACGCGGTCCCGCCGGATCCCG	0.617000													3	20					0.00024832	0.000276165	0.150653	1	0
ERLIN2	11160	broad.mit.edu	37	8	37607944	37607944	+	Missense_Mutation	SNP	G	G	A	rs149254654		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:37607944G>A	ENST00000276461.5	+	9	656	c.589G>A	c.(589-591)Gcc>Acc	p.A197T	ERLIN2_ENST00000519638.1_Missense_Mutation_p.A197T	NM_007175.6	NP_009106.1	O94905	ERLN2_HUMAN	ER lipid raft associated 2	197	Interaction with ERLIN1.				ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	protein binding			NS(1)|large_intestine(1)|lung(5)	7		Lung NSC(58;0.174)	BRCA - Breast invasive adenocarcinoma(5;6.14e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			TCTCATTGCCGCCCAGAAACA	0.502000													4	52					0	0	0.150653	0	0
TIAM1	7074	broad.mit.edu	37	21	32638884	32638884	+	Nonsense_Mutation	SNP	G	G	T	rs151048315	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr21:32638884G>T	ENST00000286827.3	-	5	876	c.405C>A	c.(403-405)taC>taA	p.Y135*	TIAM1_ENST00000469412.1_Intron|TIAM1_ENST00000541036.1_Nonsense_Mutation_p.Y135*	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	135					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CGTCATCCCCGTAAAGCCTGC	0.537000													15	47					4.14922e-12	6.0929e-12	0.500413	1	0
TULP4	56995	broad.mit.edu	37	6	158924189	158924189	+	Missense_Mutation	SNP	G	G	C	rs144691972		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:158924189G>C	ENST00000367097.3	+	13	4851	c.3494G>C	c.(3493-3495)cGa>cCa	p.R1165P	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	1165					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GACGTGTCCCGACTGCCCTTC	0.562000													23	88					0	0	0.667858	0	0
PLCB4	5332	broad.mit.edu	37	20	9288539	9288539	+	Nonsense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:9288539C>G	ENST00000378501.2	+	1	93	c.78C>G	c.(76-78)taC>taG	p.Y26*	PLCB4_ENST00000334005.3_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000414679.2_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378493.1_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000378473.3_Nonsense_Mutation_p.Y26*|PLCB4_ENST00000278655.4_Nonsense_Mutation_p.Y26*	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	26					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TTGACAGATACGAGGAGGTAA	0.294000													15	11					0	0	0.500413	0	0
CYP2B6	1555	broad.mit.edu	37	19	41512964	41512964	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:41512964C>T	ENST00000324071.4	+	4	646	c.639C>T	c.(637-639)ttC>ttT	p.F213F	CYP2B6_ENST00000593831.1_Intron|CYP2B6_ENST00000330446.5_Intron|CYP2B6_ENST00000598834.1_3'UTR	NM_000767.4	NP_000758.1	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B, polypeptide 6	213					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	GCTCTGTATTCGGCCAGGTCA	0.512000													5	121					0	0	0.184627	0	0
ZNF512B	57473	broad.mit.edu	37	20	62595516	62595516	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:62595516C>A	ENST00000450537.1	-	8	1448	c.1388G>T	c.(1387-1389)gGg>gTg	p.G463V	ZNF512B_ENST00000369888.1_Missense_Mutation_p.G463V|ZNF512B_ENST00000217130.3_Missense_Mutation_p.G463V			Q96KM6	Z512B_HUMAN	zinc finger protein 512B	463					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(16)|ovary(1)|prostate(4)|skin(1)	33	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					AGGGCCTGGCCCCTCCTGCTT	0.662000													47	78					4.64027e-19	7.79822e-19	0.870114	1	0
OR8H1	219469	broad.mit.edu	37	11	56057903	56057903	+	Silent	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:56057903T>G	ENST00000313022.2	-	1	663	c.636A>C	c.(634-636)acA>acC	p.T212T		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					ATGCAGATATTGTGATAAGGG	0.423000													11	100					0	0	0.387290	0	0
BABAM1	29086	broad.mit.edu	37	19	17384795	17384795	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:17384795G>A	ENST00000359435.4	+	4	620	c.427G>A	c.(427-429)Gag>Aag	p.E143K	BABAM1_ENST00000447614.2_Missense_Mutation_p.E143K|CTD-2278I10.6_ENST00000596542.1_Missense_Mutation_p.E65K|BABAM1_ENST00000598188.1_Missense_Mutation_p.E143K|BABAM1_ENST00000601043.1_Missense_Mutation_p.E143K|BABAM1_ENST00000595632.1_Intron|BABAM1_ENST00000448635.2_3'UTR	NM_001033549.1	NP_001028721.1	Q9NWV8	BABA1_HUMAN	BRISC and BRCA1 A complex member 1	143	VWFA-like.				chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of DNA repair|protein K63-linked deubiquitination|response to ionizing radiation	BRCA1-A complex|BRISC complex|cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	5						CAAAAGCCACGAGTTTGCACT	0.602000													5	33					0	0	0.184627	0	0
C2orf61	285051	broad.mit.edu	37	2	47357382	47357382	+	Silent	SNP	C	C	T	rs139021832		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:47357382C>T	ENST00000294947.2	-	4	452	c.417G>A	c.(415-417)ccG>ccA	p.P139P	CALM2_ENST00000422269.1_5'UTR|C2orf61_ENST00000445927.2_Silent_p.P139P	NM_173649.2	NP_775920.1	Q8N801	CB061_HUMAN	chromosome 2 open reading frame 61	139										endometrium(1)|kidney(1)|lung(2)	4		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TGTATTGCCCCGGAGAAAGCT	0.393000													9	77					0	0	0.361761	0	0
BAI1	575	broad.mit.edu	37	8	143559546	143559546	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:143559546G>T	ENST00000517894.1	+	7	2281		c.e7-1		BAI1_ENST00000323289.5_Splice_Site			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1						axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TTCCTCCCCCGGGCCGGGCAG	0.657000													7	4					5.18039e-06	6.16956e-06	0.278610	1	0
PTPRB	5787	broad.mit.edu	37	12	70949649	70949649	+	Splice_Site	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:70949649C>T	ENST00000334414.6	-	19	5038		c.e19+1		PTPRB_ENST00000538708.1_Splice_Site|PTPRB_ENST00000550857.1_Splice_Site|PTPRB_ENST00000261266.5_Splice_Site|PTPRB_ENST00000550358.1_Splice_Site|PTPRB_ENST00000451516.2_Splice_Site	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B						angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGGACACTTACGGTCTATCAT	0.522000													3	27					0	0	0.150653	0	0
WTIP	126374	broad.mit.edu	37	19	34983973	34983973	+	Silent	SNP	C	C	T	rs61729861		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:34983973C>T	ENST00000590071.2	+	3	1138	c.801C>T	c.(799-801)aaC>aaT	p.N267N	WTIP_ENST00000270288.6_Silent_p.N491N	NM_001080436.1	NP_001073905.1			Wilms tumor 1 interacting protein											NS(1)|large_intestine(2)|lung(1)	4	all_lung(56;5.94e-07)|Lung NSC(56;9.35e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			CGTTCTACAACGTGGGTGAGA	0.627000													4	99					0	0	0.184627	0	0
DCLK1	9201	broad.mit.edu	37	13	36428696	36428696	+	Silent	SNP	C	C	A	rs151019237	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:36428696C>A	ENST00000255448.4	-	6	1186	c.975G>T	c.(973-975)ccG>ccT	p.P325P	DCLK1_ENST00000460982.1_5'UTR|DCLK1_ENST00000379893.1_Silent_p.P18P|DCLK1_ENST00000379892.4_Silent_p.P325P|DCLK1_ENST00000360631.3_Silent_p.P325P	NM_004734.4	NP_004725.1	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	325	Pro/Ser-rich.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(18)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(6)|urinary_tract(1)	64		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		TGCCTGAGCGCGGAGTAGAGA	0.473000													21	23					3.08376e-08	4.02085e-08	0.654019	1	0
CDH12	1010	broad.mit.edu	37	5	21752263	21752263	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:21752263G>T	ENST00000382254.1	-	15	3054	c.1968C>A	c.(1966-1968)aaC>aaA	p.N656K	RP11-804N13.1_ENST00000522350.1_RNA|CDH12_ENST00000504376.2_Missense_Mutation_p.N656K|CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000522262.1_Missense_Mutation_p.N616K	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	656					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AATGGATGACGTTGTCTCTGA	0.448000										HNSCC(59;0.17)			37	49					2.20474e-14	3.41142e-14	0.788014	1	0
C2orf48	348738	broad.mit.edu	37	2	10350513	10350513	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:10350513G>T	ENST00000381786.3	+	4	559	c.270G>T	c.(268-270)ccG>ccT	p.P90P		NM_182626.2	NP_872432.1	Q96LS8	CB048_HUMAN	chromosome 2 open reading frame 48	90			P -> L (in dbSNP:rs13406078).							endometrium(1)|lung(7)	8	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		GAGAGCCACCGTGGTGCTCAC	0.532000													36	43					3.6622e-26	6.47845e-26	0.788014	1	0
CACNA1A	773	broad.mit.edu	37	19	13397780	13397780	+	Splice_Site	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:13397780T>C	ENST00000360228.5	-	20	3089	c.3089_splice	c.e20-1	p.K1030_splice	CACNA1A_ENST00000573710.2_Splice_Site_p.K1031_splice	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1031					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CCTGGTTCTCTCTGAGGAAGG	0.537000													15	7					0	0	0.520397	0	0
BCAM	4059	broad.mit.edu	37	19	45322965	45322965	+	Missense_Mutation	SNP	G	G	A	rs147138000		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:45322965G>A	ENST00000391955.1	+	13	1789	c.1745G>A	c.(1744-1746)cGg>cAg	p.R582Q	BCAM_ENST00000270233.6_Missense_Mutation_p.R582Q			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	582					cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				TGCCGCCAGCGGCGGGAGAAG	0.637000													4	15					0	0	0.217242	0	0
PCM1	5108	broad.mit.edu	37	8	17823551	17823551	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:17823551C>A	ENST00000325083.8	+	19	3338	c.2899C>A	c.(2899-2901)Cct>Act	p.P967T	PCM1_ENST00000519253.1_Missense_Mutation_p.P967T|PCM1_ENST00000524226.1_Missense_Mutation_p.P968T	NM_006197.3	NP_006188.3	Q15154	PCM1_HUMAN	pericentriolar material 1	967					centrosome organization|cilium assembly|G2/M transition of mitotic cell cycle|interkinetic nuclear migration|microtubule anchoring|negative regulation of neurogenesis|protein localization to centrosome	centriolar satellite|cytosol|nuclear membrane|pericentriolar material	identical protein binding		PCM1/JAK2(30)	breast(4)|endometrium(8)|kidney(5)|large_intestine(16)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	48				Colorectal(111;0.0789)		AAATTATCGTCCTTTAGCCAA	0.378000			T	"""RET, JAK2"""	"""papillary thyroid, CML, MPD"""								9	24					0.00010058	0.00011374	0.411799	1	0
ZNF407	55628	broad.mit.edu	37	18	72344061	72344061	+	Silent	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:72344061T>G	ENST00000299687.5	+	1	1086	c.1086T>G	c.(1084-1086)gtT>gtG	p.V362V	ZNF407_ENST00000309902.6_Silent_p.V362V|ZNF407_ENST00000577538.1_Silent_p.V362V|ZNF407_ENST00000582337.1_Silent_p.V362V	NM_017757.2	NP_060227.2	Q9C0G0	ZN407_HUMAN	zinc finger protein 407	362					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(21)|lung(23)|ovary(4)|prostate(3)|upper_aerodigestive_tract(2)	67		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		TAGAGATTGTTGAAGAACATG	0.398000													9	30					0	0	0.307466	0	0
OR6B1	135946	broad.mit.edu	37	7	143701639	143701639	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:143701639G>T	ENST00000408922.2	+	1	618	c.550G>T	c.(550-552)Gta>Tta	p.V184L		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					CATCTCTCCAGTACTTAATCT	0.468000													31	47					1.75199e-13	2.63015e-13	0.717897	1	0
IRX5	10265	broad.mit.edu	37	16	54967504	54967504	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:54967504C>G	ENST00000394636.4	+	3	1508	c.1171C>G	c.(1171-1173)Cct>Gct	p.P391A	IRX5_ENST00000558597.1_Missense_Mutation_p.P325A|IRX5_ENST00000320990.5_Missense_Mutation_p.P390A|IRX5_ENST00000560154.1_Missense_Mutation_p.P171A			P78411	IRX5_HUMAN	iroquois homeobox 5	391					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|vitamin D binding			kidney(3)|large_intestine(6)|lung(4)|prostate(1)	14						GGCGCAGTGTCCTTTTCCAGG	0.692000													4	21					0	0	0.184627	0	0
TBX3	6926	broad.mit.edu	37	12	115118696	115118696	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:115118696G>A	ENST00000349155.2	-	2	1608	c.645C>T	c.(643-645)gaC>gaT	p.D215D	TBX3_ENST00000257566.3_Silent_p.D215D	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	215					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		ATCCATGTTTGTCTGAAATGT	0.448000													9	114					0	0	0.307466	0	0
GABBR1	2550	broad.mit.edu	37	6	29571327	29571327	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:29571327T>C	ENST00000377034.4	-	23	3214	c.2879A>G	c.(2878-2880)tAt>tGt	p.Y960C	GABBR1_ENST00000376977.3_3'UTR|GABBR1_ENST00000355973.3_Missense_Mutation_p.Y843C|GABBR1_ENST00000377012.4_Missense_Mutation_p.Y843C|GABBR1_ENST00000377016.4_Missense_Mutation_p.Y898C	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	960					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	ccctcACTTATAAAGCAAATG	0.657000													3	7					0	0	0.115264	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187702207	187702207	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:187702207G>T	ENST00000295131.2	-	5	608	c.569C>A	c.(568-570)tCc>tAc	p.S190Y		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	190					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TTTCAACATGGAAGTGTTTGA	0.348000													12	51					6.42651e-13	9.6001e-13	0.387290	1	0
THSD7B	80731	broad.mit.edu	37	2	137852671	137852671	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:137852671A>C	ENST00000409968.1	+	4	1357	c.1179A>C	c.(1177-1179)gaA>gaC	p.E393D	THSD7B_ENST00000543459.1_Missense_Mutation_p.E252D|THSD7B_ENST00000272643.3_Missense_Mutation_p.E393D|THSD7B_ENST00000413152.2_Missense_Mutation_p.E362D					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTGAAGGAGAACTTCTGCAGC	0.443000													5	28					0	0	0.217242	0	0
MAP2K7	5609	broad.mit.edu	37	19	7977303	7977303	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:7977303C>T	ENST00000545011.1	+	11	1438	c.1373C>T	c.(1372-1374)cCc>cTc	p.P458L	MAP2K7_ENST00000397979.3_Missense_Mutation_p.P416L|MAP2K7_ENST00000397981.3_Missense_Mutation_p.P423L|MAP2K7_ENST00000397983.3_Missense_Mutation_p.P432L			O14733	MP2K7_HUMAN	mitogen-activated protein kinase kinase 7	416					activation of JUN kinase activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleus	ATP binding|JUN kinase kinase activity|magnesium ion binding|protein binding|protein kinase binding|protein phosphatase binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(3)|endometrium(1)|large_intestine(8)|lung(4)|ovary(1)	19					Etoposide(DB00773)	CCCCACCTGCCCTTCTTCAGG	0.687000													11	11					0	0	0.387290	0	0
POTEE	445582	broad.mit.edu	37	2	132021821	132021821	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:132021821C>A	ENST00000356920.5	+	15	2887	c.2793C>A	c.(2791-2793)gcC>gcA	p.A931A	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	931	Actin-like.						ATP binding										CCACGGCGGCCTCCAGCTCCT	0.612000													44	257					7.05121e-23	1.21885e-22	0.853193	1	0
GRM3	2913	broad.mit.edu	37	7	86415678	86415678	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:86415678C>A	ENST00000361669.2	+	3	1669	c.570C>A	c.(568-570)acC>acA	p.T190T	GRM3_ENST00000439827.1_Silent_p.T190T|GRM3_ENST00000394720.2_Silent_p.T188T|AC005009.2_ENST00000452471.1_RNA|GRM3_ENST00000536043.1_Silent_p.T62T|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000546348.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	190					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TTGCCAGGACCGTGCCCCCCG	0.567000													9	104					0.0477658	0.0497389	0.307466	1	0
ZZEF1	23140	broad.mit.edu	37	17	3969745	3969745	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:3969745G>C	ENST00000381638.2	-	28	4369	c.4245C>G	c.(4243-4245)agC>agG	p.S1415R		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1415							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						ACTCACCCAGGCTCTCAGGGT	0.453000													12	105					0	0	0.479597	0	0
WWC2	80014	broad.mit.edu	37	4	184210685	184210685	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:184210685G>A	ENST00000403733.3	+	21	3480	c.3281G>A	c.(3280-3282)cGg>cAg	p.R1094Q	WWC2_ENST00000508747.1_Missense_Mutation_p.R222Q|WWC2_ENST00000504005.1_Missense_Mutation_p.R776Q|WWC2_ENST00000513834.1_Missense_Mutation_p.R1045Q|WWC2_ENST00000448232.2_Missense_Mutation_p.R1118Q	NM_024949.5	NP_079225.5	Q6AWC2	WWC2_HUMAN	WW and C2 domain containing 2	1094										NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	32		all_lung(41;5.28e-14)|Lung NSC(41;1.35e-13)|Colorectal(36;0.00681)|Hepatocellular(41;0.00886)|Renal(120;0.00992)|Prostate(90;0.0237)|all_hematologic(60;0.0592)|Esophageal squamous(56;0.179)|all_neural(102;0.202)		all cancers(43;3.38e-24)|Epithelial(43;1.4e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.09e-09)|GBM - Glioblastoma multiforme(59;3.33e-05)|Colorectal(24;3.58e-05)|STAD - Stomach adenocarcinoma(60;4.21e-05)|COAD - Colon adenocarcinoma(29;0.000171)|LUSC - Lung squamous cell carcinoma(40;0.0145)|READ - Rectum adenocarcinoma(43;0.242)		AGGGACTTGCGGCAGAAGCTG	0.577000													3	21					0	0	0.115264	0	0
AHNAK2	113146	broad.mit.edu	37	14	105416406	105416406	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:105416406C>G	ENST00000333244.5	-	7	5501	c.5382G>C	c.(5380-5382)gaG>gaC	p.E1794D	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1794						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CTCCTGGAGCCTCGACGTCCA	0.627000													88	140					0	0	0.870114	0	0
NT5C1A	84618	broad.mit.edu	37	1	40131283	40131283	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:40131283G>T	ENST00000235628.1	-	3	342	c.343C>A	c.(343-345)Cct>Act	p.P115T		NM_032526.1	NP_115915.1	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	115					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			breast(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)	15	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			TCACTATCAGGGTACAGCTCC	0.557000													7	22					2.0095e-06	2.42664e-06	0.248553	1	0
TPO	7173	broad.mit.edu	37	2	1488432	1488432	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:1488432G>A	ENST00000345913.4	+	9	1494	c.1403G>A	c.(1402-1404)gGt>gAt	p.G468D	TPO_ENST00000346956.3_Missense_Mutation_p.G468D|TPO_ENST00000382201.3_Missense_Mutation_p.G468D|TPO_ENST00000349624.3_Missense_Mutation_p.G295D|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000337415.3_Missense_Mutation_p.G468D|TPO_ENST00000329066.4_Missense_Mutation_p.G468D|TPO_ENST00000382198.1_Missense_Mutation_p.G295D	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	468					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CAGTACGTGGGTCCCTATGAA	0.597000													19	39					0	0	0.539581	0	0
OR2G3	81469	broad.mit.edu	37	1	247769130	247769130	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:247769130C>T	ENST00000320002.2	+	1	275	c.243C>T	c.(241-243)acC>acT	p.T81T	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	81					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTCCTCAGACCTTAGTTAACT	0.458000													33	336					0	0	0.750413	0	0
KCNA5	3741	broad.mit.edu	37	12	5154822	5154822	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:5154822C>A	ENST00000252321.3	+	1	1738	c.1509C>A	c.(1507-1509)gcC>gcA	p.A503A		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	503						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						GTGCCATCGCCGGGGTCCTCA	0.612000													39	53					5.78141e-17	9.40257e-17	0.864702	1	0
RBP3	5949	broad.mit.edu	37	10	48390570	48390570	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:48390570G>T	ENST00000224600.4	-	1	421	c.308C>A	c.(307-309)cCa>cAa	p.P103Q		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	103	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GGTGAGTGCTGGGACTTGTGG	0.637000													43	58					3.7052e-28	6.61253e-28	0.864702	1	0
THSD7B	80731	broad.mit.edu	37	2	138000066	138000066	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:138000066T>A	ENST00000409968.1	+	10	2368	c.2190T>A	c.(2188-2190)tgT>tgA	p.C730*	THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000272643.3_Nonsense_Mutation_p.C730*|THSD7B_ENST00000413152.2_Nonsense_Mutation_p.C699*					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TGCGCCCCTGTTTTCTCCCAT	0.478000													22	31					0	0	0.681144	0	0
TUBA3D	113457	broad.mit.edu	37	2	132236926	132236926	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:132236926A>G	ENST00000321253.6	+	3	379	c.272A>G	c.(271-273)cAg>cGg	p.Q91R	TUBA3D_ENST00000409047.2_3'UTR	NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	91					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		CACCCGGAGCAGCTGATCACC	0.527000													57	94					0	0	0.870114	0	0
SNX9	51429	broad.mit.edu	37	6	158288666	158288666	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:158288666G>T	ENST00000392185.3	+	2	270		c.e2+1			NM_016224.3	NP_057308.1	Q9Y5X1	SNX9_HUMAN	sorting nexin 9						cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		CACAAATCCGGTAAGAGAACT	0.413000													16	34					1.52009e-12	2.2596e-12	0.479597	1	0
SLC22A25	387601	broad.mit.edu	37	11	62931422	62931422	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:62931422G>C	ENST00000306494.6	-	9	1517	c.1518C>G	c.(1516-1518)atC>atG	p.I506M	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000525620.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	506					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						GGCCAGAGAGGATGGCAAAGA	0.498000													11	96					0	0	0.411799	0	0
RASGRP3	25780	broad.mit.edu	37	2	33747032	33747032	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:33747032G>A	ENST00000403687.3	+	7	1119	c.379G>A	c.(379-381)Gac>Aac	p.D127N	RASGRP3_ENST00000407811.1_Missense_Mutation_p.D127N|RASGRP3_ENST00000402538.3_Missense_Mutation_p.D127N	NM_001139488.1	NP_001132960.1	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	127					MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|stomach(2)	11	all_hematologic(175;0.115)					TCCTTCCTATGACTGGATGAG	0.443000													29	99					0	0	0.740014	0	0
PNLIP	5406	broad.mit.edu	37	10	118314998	118314998	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:118314998G>T	ENST00000369221.2	+	8	818	c.790G>T	c.(790-792)Gac>Tac	p.D264Y		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	264					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	TCAGATTGTGGACATAGACGG	0.408000													43	126					2.43468e-25	4.26951e-25	0.870114	1	0
OR4D11	219986	broad.mit.edu	37	11	59271269	59271269	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:59271269C>A	ENST00000313253.1	+	1	221	c.221C>A	c.(220-222)tCc>tAc	p.S74Y		NM_001004706.1	NP_001004706.1	Q8NGI4	OR4DB_HUMAN	olfactory receptor, family 4, subfamily D, member 11	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29						ATCTGCTTCTCCTCCACAACT	0.488000													93	107					4.21487e-37	7.70392e-37	0.870114	1	0
ATR	545	broad.mit.edu	37	3	142272122	142272122	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:142272122T>C	ENST00000350721.4	-	13	2873	c.2752A>G	c.(2752-2754)Aaa>Gaa	p.K918E	ATR_ENST00000383101.3_Missense_Mutation_p.K854E	NM_001184.3	NP_001175.2	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related	918					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			NS(1)|breast(10)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|liver(2)|lung(45)|ovary(3)|skin(10)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(4)	122						TTAACACTTTTAGCTGCAACC	0.408000								Other conserved DNA damage response genes					9	50					0	0	0.335167	0	0
OR4D5	219875	broad.mit.edu	37	11	123810885	123810885	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:123810885G>T	ENST00000307033.2	+	1	636	c.562G>T	c.(562-564)Gcc>Tcc	p.A188S		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	188					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GATCAAATTGGCCTGCACAGA	0.468000													10	93					1.58986e-06	1.92374e-06	0.361761	1	0
MARK2	2011	broad.mit.edu	37	11	63665752	63665752	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:63665752G>T	ENST00000402010.2	+	4	916	c.337_splice	c.e4+1	p.V113_splice	MARK2_ENST00000361128.5_Splice_Site_p.V113_splice|MARK2_ENST00000350490.7_Splice_Site_p.V113_splice|MARK2_ENST00000377809.4_Splice_Site_p.V113_splice|MARK2_ENST00000408948.3_Splice_Site_p.V80_splice|MARK2_ENST00000502399.3_Splice_Site_p.V113_splice|MARK2_ENST00000425897.2_Splice_Site_p.V80_splice|MARK2_ENST00000413835.2_Splice_Site_p.V113_splice|MARK2_ENST00000513765.2_Splice_Site_p.V80_splice|MARK2_ENST00000315032.8_Splice_Site_p.V113_splice|MARK2_ENST00000508192.1_Splice_Site_p.V113_splice|MARK2_ENST00000377810.3_Splice_Site_p.V80_splice|MARK2_ENST00000509502.2_Splice_Site_p.V80_splice	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	113	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						TCCCAACATAGGTGAGCACAA	0.478000													15	148					1.37285e-15	2.19149e-15	0.500413	1	0
NLRP4	147945	broad.mit.edu	37	19	56369987	56369987	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:56369987G>A	ENST00000301295.6	+	3	1650	c.1228G>A	c.(1228-1230)Gac>Aac	p.D410N	NLRP4_ENST00000346986.5_Missense_Mutation_p.D410N|NLRP4_ENST00000587891.1_Missense_Mutation_p.D335N	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	410	NACHT.						ATP binding	p.D410N(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TATGTGGACAGACACATTTGA	0.572000													15	70					0	0	0.479597	0	0
SLC24A4	123041	broad.mit.edu	37	14	92958097	92958097	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:92958097C>T	ENST00000532405.1	+	15	1852	c.1626C>T	c.(1624-1626)acC>acT	p.T542T	SLC24A4_ENST00000393265.2_Silent_p.T478T|SLC24A4_ENST00000351924.5_Silent_p.T506T|SLC24A4_ENST00000531433.1_Silent_p.T523T|SLC24A4_ENST00000298877.1_Silent_p.T525T			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	542						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		GCCTGCAGACCATGGTTGTTA	0.517000													15	32					0	0	0.479597	0	0
KIF2B	84643	broad.mit.edu	37	17	51901335	51901335	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:51901335G>T	ENST00000268919.4	+	1	1097	c.941G>T	c.(940-942)gGt>gTt	p.G314V		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	314	Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						TACACCATGGGTGGAGACTTT	0.542000													20	64					1.00905e-13	1.52238e-13	0.575678	1	0
SPERT	220082	broad.mit.edu	37	13	46287784	46287784	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:46287784C>A	ENST00000378966.3	+	2	932	c.516C>A	c.(514-516)ggC>ggA	p.G172G	SPERT_ENST00000310521.1_Silent_p.G208G			Q8NA61	SPERT_HUMAN	spermatid associated	208						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CCTCGCTGGGCCGAGAGGAGA	0.652000													9	22					7.48243e-07	9.21969e-07	0.335167	1	0
CSMD3	114788	broad.mit.edu	37	8	113349026	113349026	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:113349026C>A	ENST00000297405.5	-	44	7118	c.6874G>T	c.(6874-6876)Ggc>Tgc	p.G2292C	CSMD3_ENST00000352409.3_Missense_Mutation_p.G2222C|CSMD3_ENST00000455883.2_Missense_Mutation_p.G2188C|CSMD3_ENST00000343508.3_Missense_Mutation_p.G2252C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2292	CUB 13.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TAAATGGTGCCATTCATTGCA	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	115					0.000274275	0.000303913	0.307466	1	0
DEDD2	162989	broad.mit.edu	37	19	42713941	42713941	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:42713941C>T	ENST00000595337.1	-	4	587	c.500G>A	c.(499-501)gGt>gAt	p.G167D	DEDD2_ENST00000596251.1_Missense_Mutation_p.G167D|DEDD2_ENST00000598727.1_Missense_Mutation_p.G167D|DEDD2_ENST00000593804.1_5'UTR|DEDD2_ENST00000336034.4_Missense_Mutation_p.G162D	NM_001270614.1	NP_001257543.1	Q8WXF8	DEDD2_HUMAN	death effector domain containing 2	167					activation of pro-apoptotic gene products|apoptotic nuclear change|cellular homeostasis|induction of apoptosis via death domain receptors|intracellular signal transduction|negative regulation of transcription, DNA-dependent|RNA processing|rRNA catabolic process|transcription, DNA-dependent	nucleolus	DNA binding|receptor signaling complex scaffold activity			endometrium(1)|large_intestine(1)|ovary(1)|prostate(2)	5		Prostate(69;0.0704)				CCGTCTGGCACCACCACTGGG	0.662000													33	23					0	0	0.769981	0	0
TCERG1L	256536	broad.mit.edu	37	10	132915186	132915186	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:132915186C>A	ENST00000368642.4	-	9	1356	c.1271G>T	c.(1270-1272)tGc>tTc	p.C424F		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	424										cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		GGGACTCCCGCAGCCTTCGGT	0.572000													7	10					0.00448238	0.00479972	0.307466	1	0
KRTAP23-1	337963	broad.mit.edu	37	21	31720769	31720769	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr21:31720769G>T	ENST00000334160.4	-	1	155	c.156C>A	c.(154-156)ctC>ctA	p.L52L		NM_181624.1	NP_853655.1	A1A580	KR231_HUMAN	keratin associated protein 23-1	52						intermediate filament				large_intestine(1)|lung(4)|prostate(1)	6						CTTGCAGAGAGAGGAACCCAG	0.602000													11	29					2.80697e-09	3.76545e-09	0.387290	1	0
COL9A1	1297	broad.mit.edu	37	6	71009778	71009778	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:71009778C>T	ENST00000357250.6	-	4	425	c.267G>A	c.(265-267)ttG>ttA	p.L89L	COL9A1_ENST00000370496.3_Silent_p.L89L	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	89	Nonhelical region (NC4).|TSP N-terminal.				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						CATTATTTCCCAACTTGTAAG	0.368000													4	84					0	0	0.184627	0	0
HECTD3	79654	broad.mit.edu	37	1	45474216	45474216	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:45474216G>T	ENST00000372172.4	-	8	1301	c.1230C>A	c.(1228-1230)ctC>ctA	p.L410L	HECTD3_ENST00000372168.3_5'UTR	NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	410					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					ACCTCTGCAGGAGGACAGCTC	0.557000													27	78					2.44723e-14	3.77698e-14	0.681144	1	0
ZNF532	55205	broad.mit.edu	37	18	56586785	56586785	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:56586785G>T	ENST00000336078.4	+	4	2042	c.1266G>T	c.(1264-1266)gcG>gcT	p.A422A	ZNF532_ENST00000591083.1_Silent_p.A422A|ZNF532_ENST00000591808.1_Silent_p.A422A|ZNF532_ENST00000591230.1_Silent_p.A422A|ZNF532_ENST00000589288.1_Silent_p.A422A	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						CCCCCAGGGCGCCTCTCCAGT	0.592000													13	10					2.27111e-07	2.87452e-07	0.411799	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176173	140176173	+	Missense_Mutation	SNP	G	G	T	rs149176013		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:140176173G>T	ENST00000526136.1	+	1	1624	c.1624G>T	c.(1624-1626)Gtg>Ttg	p.V542L	PCDHA2_ENST00000520672.2_Missense_Mutation_p.V542L|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.V542L|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGATGCGGGCGTGCCGCCTCT	0.687000													27	56					7.01153e-11	9.79672e-11	0.717897	1	0
OR5M9	390162	broad.mit.edu	37	11	56230648	56230648	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:56230648G>C	ENST00000279791.1	-	1	229	c.230C>G	c.(229-231)cCc>cGc	p.P77R		NM_001004743.1	NP_001004743.1	Q8NGP3	OR5M9_HUMAN	olfactory receptor, family 5, subfamily M, member 9	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	36	Esophageal squamous(21;0.00448)					CAGCATTTTGGGGGTAACGTT	0.448000													9	51					0	0	0.307466	0	0
UNC5B	219699	broad.mit.edu	37	10	73047497	73047497	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:73047497G>T	ENST00000335350.6	+	6	1292	c.876G>T	c.(874-876)aaG>aaT	p.K292N	UNC5B_ENST00000373192.4_Missense_Mutation_p.K292N	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	292	TSP type-1 1.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						CATTCCAGAAGACCGCCTGCA	0.657000													4	36					1.23904e-05	1.44714e-05	0.184627	1	0
ACACB	32	broad.mit.edu	37	12	109577566	109577566	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:109577566G>T	ENST00000338432.7	+	2	475	c.356G>T	c.(355-357)gGg>gTg	p.G119V	ACACB_ENST00000377848.3_Missense_Mutation_p.G119V|ACACB_ENST00000377854.5_Missense_Mutation_p.G119V			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	119					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CAAGCCAACGGGACTGGGACA	0.622000													52	105					2.74224e-37	5.02745e-37	0.870114	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121699934	121699934	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:121699934G>C	ENST00000393386.2	+	29	7210	c.6799G>C	c.(6799-6801)Gct>Cct	p.A2267P	PTPRZ1_ENST00000449182.1_Missense_Mutation_p.A1400P	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	2267	Tyrosine-protein phosphatase 2.				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						AGGAGTCTTTGCTGACATTGT	0.403000													32	29					0	0	0.769981	0	0
GPR112	139378	broad.mit.edu	37	X	135496331	135496331	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:135496331G>T	ENST00000394143.1	+	25	9341	c.9050G>T	c.(9049-9051)cGg>cTg	p.R3017L	GPR112_ENST00000412101.1_Missense_Mutation_p.R2812L|GPR112_ENST00000394141.1_Missense_Mutation_p.R2812L|GPR112_ENST00000370652.1_Missense_Mutation_p.R3017L|GPR112_ENST00000287534.4_Missense_Mutation_p.R2736L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	3017					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GGGAGCAGCCGGTGTCAGATA	0.353000													11	76					7.03913e-09	9.35972e-09	0.411799	1	0
FAM47C	442444	broad.mit.edu	37	X	37028267	37028267	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:37028267C>T	ENST00000358047.3	+	1	1836	c.1784C>T	c.(1783-1785)cCc>cTc	p.P595L		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	595										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCCAGTCTCCCCCCGGAGCCC	0.647000													32	42					0	0	0.864702	0	0
FRMPD2	143162	broad.mit.edu	37	10	49440192	49440192	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:49440192C>T	ENST00000374201.3	-	10	1436	c.1134G>A	c.(1132-1134)gaG>gaA	p.E378E	FRMPD2_ENST00000407470.4_Silent_p.E347E|FRMPD2_ENST00000305531.3_Silent_p.E354E	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	378	FERM.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		AGGTGAGTTCCTCGAGGTTGG	0.522000													13	80					0	0	0.500413	0	0
FBXO24	26261	broad.mit.edu	37	7	100189329	100189329	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:100189329G>A	ENST00000241071.6	+	4	684	c.362G>A	c.(361-363)cGc>cAc	p.R121H	FBXO24_ENST00000468962.1_Missense_Mutation_p.R109H|FBXO24_ENST00000498195.1_3'UTR|FBXO24_ENST00000465843.1_Missense_Mutation_p.R107H|PCOLCE-AS1_ENST00000442166.2_RNA|FBXO24_ENST00000427939.2_Missense_Mutation_p.R159H|FBXO24_ENST00000360609.2_Missense_Mutation_p.R107H	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	121						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GGAGGCCGCCGCCGATGTCTC	0.582000													14	51					0	0	0.457914	0	0
PNLIP	5406	broad.mit.edu	37	10	118314997	118314997	+	Silent	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:118314997G>C	ENST00000369221.2	+	8	817	c.789G>C	c.(787-789)gtG>gtC	p.V263V		NM_000936.2	NP_000927.1	P16233	LIPP_HUMAN	pancreatic lipase	263					lipid catabolic process|retinoid metabolic process|steroid metabolic process	extracellular region	retinyl-palmitate esterase activity|triglyceride lipase activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(2)|lung(22)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	43				all cancers(201;0.0131)	Bentiromide(DB00522)|Orlistat(DB01083)	CTCAGATTGTGGACATAGACG	0.408000													42	128					0	0	0.870114	0	0
CLCA4	22802	broad.mit.edu	37	1	87025657	87025657	+	Missense_Mutation	SNP	G	G	C	rs148031684		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:87025657G>C	ENST00000370563.3	+	2	244	c.202G>C	c.(202-204)Gaa>Caa	p.E68Q	CLCA4_ENST00000263723.5_5'UTR	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	68						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		TGAAGCCACAGAAAAAAGATT	0.328000													9	83					0	0	0.307466	0	0
ZNF700	90592	broad.mit.edu	37	19	12060148	12060148	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:12060148G>A	ENST00000482090.1	+	3	1673	c.1255G>A	c.(1255-1257)Ggt>Agt	p.G419S	ZNF763_ENST00000591944.1_Intron|ZNF763_ENST00000590798.1_Intron|CTD-2006C1.12_ENST00000586394.1_RNA|ZNF763_ENST00000538752.1_Intron|ZNF700_ENST00000254321.5_Missense_Mutation_p.G437S			Q9H0M5	ZN700_HUMAN	zinc finger protein 700	437					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding		ZNF700/MAST1_ENST00000251472(2)	breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(13)|pancreas(1)|prostate(1)|urinary_tract(1)	33						TCGAGTGCACGGTGGGACTCA	0.483000													14	56					0	0	0.457914	0	0
MOXD1	26002	broad.mit.edu	37	6	132636912	132636912	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:132636912C>A	ENST00000367963.3	-	10	1488	c.1370G>T	c.(1369-1371)gGa>gTa	p.G457V	MOXD1_ENST00000489128.1_5'UTR|MOXD1_ENST00000336749.3_Missense_Mutation_p.G389V	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	457					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		GGTGCTTAGTCCTCCCTGAAA	0.353000													19	76					2.94398e-08	3.85522e-08	0.557998	1	0
ATP12A	479	broad.mit.edu	37	13	25283930	25283930	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:25283930C>A	ENST00000218548.6	+	19	3078	c.2745C>A	c.(2743-2745)taC>taA	p.Y915*	ATP12A_ENST00000381946.3_Nonsense_Mutation_p.Y909*	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	909					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	AGAAGGACTACGTGAATGACT	0.547000													30	40					1.30897e-18	2.18765e-18	0.740014	1	0
CSMD3	114788	broad.mit.edu	37	8	113349025	113349025	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:113349025C>A	ENST00000297405.5	-	44	7119	c.6875G>T	c.(6874-6876)gGc>gTc	p.G2292V	CSMD3_ENST00000352409.3_Missense_Mutation_p.G2222V|CSMD3_ENST00000455883.2_Missense_Mutation_p.G2188V|CSMD3_ENST00000343508.3_Missense_Mutation_p.G2252V	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2292	CUB 13.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATAAATGGTGCCATTCATTGC	0.353000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	117					0.000274275	0.000303913	0.307466	1	0
BPIFB1	92747	broad.mit.edu	37	20	31878785	31878785	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:31878785G>C	ENST00000253354.1	+	5	549	c.388G>C	c.(388-390)Gag>Cag	p.E130Q		NM_033197.2	NP_149974.2	Q8TDL5	LPLC1_HUMAN	BPI fold containing family B, member 1	130						extracellular space	lipid binding										GACCATCGTGGAGTTCCACAT	0.637000													6	14					0	0	0.217242	0	0
KEL	3792	broad.mit.edu	37	7	142651304	142651304	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:142651304C>A	ENST00000355265.2	-	8	1365	c.891G>T	c.(889-891)aaG>aaT	p.K297N	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	297					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCTGGAAGAGCTTGCCCTGTG	0.557000													13	14					1.3612e-06	1.65367e-06	0.479597	1	0
PRRC2C	23215	broad.mit.edu	37	1	171509669	171509669	+	Missense_Mutation	SNP	G	G	T	rs142556260		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:171509669G>T	ENST00000367742.3	+	16	3306	c.3064G>T	c.(3064-3066)Gta>Tta	p.V1022L	PRRC2C_ENST00000392078.3_Missense_Mutation_p.V1022L|PRRC2C_ENST00000426496.2_Missense_Mutation_p.V1020L|PRRC2C_ENST00000338920.4_Missense_Mutation_p.V1020L			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1020							protein C-terminus binding										TAAAAAACCTGTACTTAGAGA	0.423000													3	24					0.004672	0.00497634	0.115264	1	0
ERAP2	64167	broad.mit.edu	37	5	96224887	96224887	+	Splice_Site	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:96224887A>T	ENST00000437043.3	+	5	1560		c.e5-1		CTD-2260A17.2_ENST00000501338.1_Intron|ERAP2_ENST00000379904.4_Splice_Site|ERAP2_ENST00000510309.1_Splice_Site	NM_001130140.1|NM_022350.3	NP_001123612.1|NP_071745.1	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2						antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		CACATTTCCCAGGTGTCCATC	0.408000													14	27					0	0	0.435327	0	0
MYO16	23026	broad.mit.edu	37	13	109672245	109672245	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:109672245C>T	ENST00000356711.2	+	23	2842	c.2716C>T	c.(2716-2718)Cac>Tac	p.H906Y	MYO16_ENST00000251041.5_Missense_Mutation_p.H906Y|MYO16_ENST00000457511.2_Missense_Mutation_p.H418Y|MYO16_ENST00000357550.2_Missense_Mutation_p.H906Y	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	906	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			CACCATCATGCACTACGCAGG	0.453000													3	21					0	0	0.115264	0	0
OR10K2	391107	broad.mit.edu	37	1	158390612	158390612	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:158390612G>A	ENST00000314902.2	-	1	44	c.45C>T	c.(43-45)ctC>ctT	p.L15L		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					ATGAGAAGCCGAGGAAGATGA	0.512000													15	48					0	0	0.520397	0	0
PCSK1	5122	broad.mit.edu	37	5	95728882	95728882	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:95728882G>T	ENST00000311106.3	-	14	2322	c.2085C>A	c.(2083-2085)atC>atA	p.I695I	CTD-2337A12.1_ENST00000502645.2_RNA|PCSK1_ENST00000508626.1_Silent_p.I648I|PCSK1_ENST00000513085.1_5'UTR	NM_000439.4|NM_001177876.1	NP_000430.3|NP_001171347.1	P29120	NEC1_HUMAN	proprotein convertase subtilisin/kexin type 1	695					cell-cell signaling|cellular nitrogen compound metabolic process|energy reserve metabolic process|hormone biosynthetic process|peptide biosynthetic process|peptide hormone processing|regulation of insulin secretion	extracellular space|stored secretory granule|transport vesicle	serine-type endopeptidase activity			NS(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	36		all_cancers(142;2.67e-06)|all_epithelial(76;6.92e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0112)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;3.44e-16)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTTCATAAGGGATGTTGAGCT	0.448000													19	71					6.94344e-10	9.46122e-10	0.539581	1	0
MSMB	4477	broad.mit.edu	37	10	51556792	51556792	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:51556792G>C	ENST00000358559.2	+	3	238	c.151G>C	c.(151-153)Gag>Cag	p.E51Q	MSMB_ENST00000298239.6_Intron|MSMB_ENST00000474170.1_3'UTR	NM_002443.3	NP_002434.1	P08118	MSMB_HUMAN	microseminoprotein, beta-	51						extracellular space|nucleus				lung(4)|ovary(2)|prostate(1)	7						AATAAACTCGGAGTGGCAGAC	0.443000													20	34					0	0	0.624587	0	0
T	6862	broad.mit.edu	37	6	166575945	166575945	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:166575945G>T	ENST00000296946.2	-	7	1362	c.894C>A	c.(892-894)aaC>aaA	p.N298K	T_ENST00000366871.3_Intron	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	298					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		TTGGAGAATTGTTCCGATGAG	0.577000									Chordoma, Familial Clustering of				15	30					6.31663e-08	8.18321e-08	0.479597	1	0
DCHS2	54798	broad.mit.edu	37	4	155305557	155305557	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:155305557C>A	ENST00000357232.3	-	2	196	c.197G>T	c.(196-198)aGc>aTc	p.S66I	DCHS2_ENST00000339452.1_Intron	NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	66	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		ctcttcctggcttctgaacac	0.507000													7	11					0.248553	0.252306	0.248553	1	0
VWC2L	402117	broad.mit.edu	37	2	215440444	215440444	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:215440444T>G	ENST00000312504.5	+	4	1371	c.569T>G	c.(568-570)gTg>gGg	p.V190G	VWC2L_ENST00000427124.1_3'UTR|AC107218.3_ENST00000412896.1_RNA|AC107218.3_ENST00000437883.1_RNA	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	190						extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						GGCATTGAAGTGAAAGTGGAC	0.458000													30	97					0	0	0.729181	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458253	45458253	+	RNA	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:45458253G>T	ENST00000548424.1	+	0	448																											ATAGAATTCAGGTTTAATAAC	0.468000													6	5					0.00116845	0.00126914	0.217242	1	0
DMP1	1758	broad.mit.edu	37	4	88584434	88584434	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:88584434G>A	ENST00000339673.6	+	6	1603	c.1504G>A	c.(1504-1506)Ggg>Agg	p.G502R	RP11-742B18.1_ENST00000506480.1_RNA|DMP1_ENST00000282479.7_Missense_Mutation_p.G486R|RP11-742B18.1_ENST00000507894.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	502					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding	p.G502W(1)		breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		CAAACCCATTGGGGACCAAGA	0.438000													36	39					0	0	0.819951	0	0
FIG4	9896	broad.mit.edu	37	6	110037688	110037688	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:110037688G>T	ENST00000230124.3	+	3	330	c.206G>T	c.(205-207)cGc>cTc	p.R69L	FIG4_ENST00000441478.2_Intron	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	69					cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CTTCTTGGCCGCTTGGATCTT	0.398000													13	40					7.93312e-07	9.73537e-07	0.457914	1	0
ARV1	64801	broad.mit.edu	37	1	231131652	231131652	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:231131652T>C	ENST00000310256.2	+	4	652	c.595T>C	c.(595-597)Tgg>Cgg	p.W199R	ARV1_ENST00000366658.2_Missense_Mutation_p.W159R|ARV1_ENST00000497753.1_3'UTR	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	199					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		AGCTGTCATTTGGGAACATGA	0.373000													26	85					0	0	0.681144	0	0
ACY3	91703	broad.mit.edu	37	11	67410317	67410317	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:67410317G>A	ENST00000255082.3	-	8	1008	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S	ACY3_ENST00000529256.1_Missense_Mutation_p.P159S	NM_080658.1	NP_542389.1	Q96HD9	ACY3_HUMAN	aspartoacylase (aminocyclase) 3	280					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding			endometrium(1)|lung(5)|prostate(2)	8					L-Aspartic Acid(DB00128)	ATGAACACGGGGTACACCGTG	0.587000													13	37					0	0	0.435327	0	0
FCRL2	79368	broad.mit.edu	37	1	157718359	157718359	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:157718359C>G	ENST00000361516.3	-	10	1491	c.1443G>C	c.(1441-1443)caG>caC	p.Q481H	FCRL2_ENST00000392274.3_Intron|FCRL2_ENST00000368181.4_Intron	NM_030764.3	NP_110391.2	Q96LA5	FCRL2_HUMAN	Fc receptor-like 2	481					cell-cell signaling	integral to membrane|plasma membrane|soluble fraction	receptor activity|SH3/SH2 adaptor activity	p.Q481Q(1)		central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|skin(2)	51	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TTTCTGGCTGCTGCATGCTCC	0.453000													12	73					0	0	0.435327	0	0
KRT5	3852	broad.mit.edu	37	12	52911461	52911461	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:52911461C>A	ENST00000252242.4	-	5	1395	c.1005G>T	c.(1003-1005)ctG>ctT	p.L335L		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	335	Linker 12.|Rod.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton	p.L335L(1)		endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGATGCTATCCAGGTCCAGGT	0.572000													28	97					1.77063e-15	2.80427e-15	0.693898	1	0
XKR7	343702	broad.mit.edu	37	20	30584719	30584719	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:30584719G>T	ENST00000217299.3	+	3	1373	c.1199G>T	c.(1198-1200)gGc>gTc	p.G400V		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	400						integral to membrane		p.G400D(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GCGCTCACCGGCTTCTGGTAC	0.582000													14	27					3.27435e-08	4.26018e-08	0.457914	1	0
ARMC4	55130	broad.mit.edu	37	10	28233798	28233798	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:28233798C>A	ENST00000305242.5	-	11	1572	c.1480G>T	c.(1480-1482)Gga>Tga	p.G494*	ARMC4_ENST00000545014.1_Nonsense_Mutation_p.G19*|ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000537576.1_Nonsense_Mutation_p.G186*	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	494							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TCCAGGCCTCCAACATCTCTG	0.468000													22	70					2.27731e-05	2.64956e-05	0.608945	1	0
KRTAP13-4	284827	broad.mit.edu	37	21	31802740	31802740	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr21:31802740G>T	ENST00000334068.2	+	1	169	c.147G>T	c.(145-147)agG>agT	p.R49S		NM_181600.1	NP_853631.1	Q3LI77	KR134_HUMAN	keratin associated protein 13-4	49	4 X 10 AA approximate repeats.					intermediate filament		p.R49R(1)		NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	15						CTCTCTACAGGGACTGTCAGA	0.627000													15	50					1.3612e-06	1.65367e-06	0.479597	1	0
ZNF114	163071	broad.mit.edu	37	19	48789422	48789422	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:48789422G>T	ENST00000595607.1	+	6	1035	c.541G>T	c.(541-543)Ggg>Tgg	p.G181W	ZNF114_ENST00000597695.1_Missense_Mutation_p.G147W|ZNF114_ENST00000600687.1_Missense_Mutation_p.G181W|ZNF114_ENST00000315849.1_Missense_Mutation_p.G181W			Q8NC26	ZN114_HUMAN	zinc finger protein 114	181					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(6)|lung(11)	18		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		TGGAGTCTTGGGGTGGAACAT	0.408000													35	38					7.61001e-30	1.36619e-29	0.812448	1	0
CAPS2	84698	broad.mit.edu	37	12	75678818	75678818	+	Missense_Mutation	SNP	C	C	A	rs148668279	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:75678818C>A	ENST00000393284.3	-	15	1400	c.799G>T	c.(799-801)Ggc>Tgc	p.G267C	CAPS2_ENST00000409799.1_Missense_Mutation_p.G417C|CAPS2_ENST00000409445.3_Missense_Mutation_p.G499C|RP11-560G2.1_ENST00000549953.1_RNA|CAPS2_ENST00000409004.1_5'UTR|CAPS2_ENST00000442339.2_Missense_Mutation_p.G89C			Q9BXY5	CAYP2_HUMAN	calcyphosine 2	499							calcium ion binding			endometrium(2)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	10						TCAACCTTGCCATTGCCATTG	0.328000													5	38					0.000602214	0.000662436	0.184627	1	0
PHLPP1	23239	broad.mit.edu	37	18	60609049	60609049	+	Missense_Mutation	SNP	C	C	G	rs74653132		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:60609049C>G	ENST00000400316.4	+	11	3304	c.1523C>G	c.(1522-1524)aCa>aGa	p.T508R	PHLPP1_ENST00000262719.5_Missense_Mutation_p.T1020R	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1020					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						TTGTATTTGACAAATAACAGC	0.468000													6	25					0	0	0.248553	0	0
OR4A16	81327	broad.mit.edu	37	11	55111085	55111085	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:55111085C>A	ENST00000314721.2	+	1	459	c.409C>A	c.(409-411)Ctg>Atg	p.L137M		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						CATGAATCGACTGGTTTGCAT	0.473000													50	59					5.73435e-26	1.01145e-25	0.870114	1	0
LIN54	132660	broad.mit.edu	37	4	83849377	83849377	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:83849377T>G	ENST00000340417.3	-	13	2505	c.2128A>C	c.(2128-2130)Aag>Cag	p.K710Q	LIN54_ENST00000395282.2_3'UTR|LIN54_ENST00000395283.2_Missense_Mutation_p.K621Q|LIN54_ENST00000510557.1_Missense_Mutation_p.K489Q|LIN54_ENST00000506560.1_Missense_Mutation_p.K621Q|LIN54_ENST00000505397.1_Missense_Mutation_p.K710Q|LIN54_ENST00000446851.2_Missense_Mutation_p.K489Q|LIN54_ENST00000442461.2_Missense_Mutation_p.K489Q	NM_194282.2	NP_919258.2	Q6MZP7	LIN54_HUMAN	lin-54 homolog (C. elegans)	710					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(2)|lung(5)	14		Hepatocellular(203;0.114)				TTTCCCTTCTTGTCTGCCTGC	0.438000													7	35					0	0	0.278610	0	0
CCDC170	80129	broad.mit.edu	37	6	151894619	151894619	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:151894619G>C	ENST00000367290.5	+	6	1174	c.1085G>C	c.(1084-1086)aGg>aCg	p.R362T	CCDC170_ENST00000239374.7_Missense_Mutation_p.R362T			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	362																	GAAGAAAGCAGGGACCGGGTG	0.488000													15	36					0	0	0.520397	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89476584	89476584	+	RNA	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:89476584G>T	ENST00000484817.1	-	0	60																											CAGAGCATTAGCAGCCCCAGA	0.532000													4	24					1.06961e-07	1.37392e-07	0.278610	1	0
ZNF500	26048	broad.mit.edu	37	16	4812313	4812313	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:4812313C>A	ENST00000219478.6	-	4	921	c.622G>T	c.(622-624)Gag>Tag	p.E208*	ZNF500_ENST00000545009.1_Nonsense_Mutation_p.E208*			O60304	ZN500_HUMAN	zinc finger protein 500	208					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	21						GACGCCATCTCCTGATGCCGG	0.662000													3	5					0.00024832	0.000276165	0.150653	1	0
FAM153B	202134	broad.mit.edu	37	5	175533569	175533569	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:175533569G>T	ENST00000253490.4	+	16	895	c.838G>T	c.(838-840)Gtg>Ttg	p.V280L	FAM153B_ENST00000510151.1_Missense_Mutation_p.V203L|FAM153B_ENST00000515817.1_Missense_Mutation_p.V203L|FAM153B_ENST00000512862.1_Missense_Mutation_p.V71L			P0C7A2	F153B_HUMAN	family with sequence similarity 153, member B	280										endometrium(3)|kidney(2)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	16	all_cancers(89;0.00406)|Renal(175;0.000269)|Lung NSC(126;0.0103)|all_lung(126;0.0164)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Kidney(146;0.0965)		CTAGATGCAGGTGGACCCAGC	0.463000													21	98					5.35356e-11	7.51486e-11	0.639603	1	0
ZC3H18	124245	broad.mit.edu	37	16	88644131	88644131	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:88644131A>G	ENST00000301011.5	+	2	800	c.600A>G	c.(598-600)atA>atG	p.I200M	ZC3H18_ENST00000452588.2_Missense_Mutation_p.I200M	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	200						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		ATGGGGAAATAGACGTGAGTA	0.537000													7	55					0	0	0.278610	0	0
PASK	23178	broad.mit.edu	37	2	242078153	242078153	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:242078153C>A	ENST00000403638.3	-	5	748	c.657G>T	c.(655-657)agG>agT	p.R219S	PASK_ENST00000544142.1_Missense_Mutation_p.R33S|PASK_ENST00000234040.4_Missense_Mutation_p.R219S|PASK_ENST00000358649.4_Missense_Mutation_p.R219S|PASK_ENST00000405260.1_Missense_Mutation_p.R219S|PASK_ENST00000539818.1_Missense_Mutation_p.R3S	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	219					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CCTGCCGCATCCTCTTCATCC	0.572000													8	62					0.000157383	0.000177313	0.278610	1	0
CLCN1	1180	broad.mit.edu	37	7	143039219	143039219	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:143039219G>T	ENST00000343257.2	+	15	1867	c.1780G>T	c.(1780-1782)Ggc>Tgc	p.G594C		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	594					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					GCCTGACCTTGGCTGGAACCA	0.537000													7	37					7.48243e-07	9.21969e-07	0.335167	1	0
PRR16	51334	broad.mit.edu	37	5	120021925	120021925	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:120021925C>G	ENST00000379551.2	+	3	724	c.367C>G	c.(367-369)Cct>Gct	p.P123A	PRR16_ENST00000505123.1_Missense_Mutation_p.P76A|PRR16_ENST00000407149.2_Missense_Mutation_p.P146A|PRR16_ENST00000446965.1_Missense_Mutation_p.P76A	NM_016644.1	NP_057728.1	Q569H4	PRR16_HUMAN	proline rich 16	146	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0464)|Prostate(80;0.00446)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.000126)|Epithelial(69;0.000331)|all cancers(49;0.00169)		AACTGCCAATCCTGTAAAAAC	0.483000													11	38					0	0	0.361761	0	0
NTM	50863	broad.mit.edu	37	11	132081930	132081930	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:132081930G>C	ENST00000374786.1	+	3	894	c.415G>C	c.(415-417)Gta>Cta	p.V139L	NTM_ENST00000425719.2_Missense_Mutation_p.V139L|NTM_ENST00000374791.3_Missense_Mutation_p.V139L|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000374784.1_Missense_Mutation_p.V139L|NTM_ENST00000539799.1_Missense_Mutation_p.V139L|NTM_ENST00000427481.2_Missense_Mutation_p.V130L	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	139	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						TCCCAAAATTGTAGAGATTTC	0.393000													4	35					0	0	0.150653	0	0
ACVRL1	94	broad.mit.edu	37	12	52308279	52308279	+	Missense_Mutation	SNP	G	G	A	rs138048445		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:52308279G>A	ENST00000550683.1	+	5	825	c.724G>A	c.(724-726)Gtc>Atc	p.V242I	ACVRL1_ENST00000419526.2_Missense_Mutation_p.V54I|ACVRL1_ENST00000388922.4_Missense_Mutation_p.V228I	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	228	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GAGTGTGGCCGTCAAGATCTT	0.567000													4	25					0	0	0.150653	0	0
IQCH	64799	broad.mit.edu	37	15	67768065	67768065	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:67768065C>G	ENST00000335894.4	+	18	2774	c.2708C>G	c.(2707-2709)aCc>aGc	p.T903S	IQCH_ENST00000546225.1_Missense_Mutation_p.T560S|IQCH_ENST00000358767.3_Missense_Mutation_p.T639S|IQCH_ENST00000360277.4_Missense_Mutation_p.T564S|IQCH-AS1_ENST00000559298.1_lincRNA	NM_001031715.2	NP_001026885.1	Q86VS3	IQCH_HUMAN	IQ motif containing H	903										NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(2)|pancreas(2)|skin(5)|upper_aerodigestive_tract(1)	33				Colorectal(3;0.0856)		GCAGTGATGACCACCCAGCTA	0.413000													4	41					0	0	0.217242	0	0
MYO1B	4430	broad.mit.edu	37	2	192261175	192261175	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:192261175G>A	ENST00000392318.3	+	21	2494	c.2247G>A	c.(2245-2247)caG>caA	p.Q749Q	MYO1B_ENST00000439065.2_Silent_p.Q23Q|MYO1B_ENST00000339514.4_Silent_p.Q749Q|MYO1B_ENST00000304164.4_Silent_p.Q749Q|MYO1B_ENST00000392316.1_Silent_p.Q749Q	NM_001130158.1	NP_001123630.1	O43795	MYO1B_HUMAN	myosin IB	749						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|central_nervous_system(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(19)|ovary(1)	55			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GGTACCAGCAGACAAAGAGTT	0.378000													16	98					0	0	0.557998	0	0
OR10AG1	282770	broad.mit.edu	37	11	55735884	55735884	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:55735884A>C	ENST00000312345.2	-	1	106	c.56T>G	c.(55-57)tTt>tGt	p.F19C		NM_001005491.1	NP_001005491.1	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG, member 1	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(24)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	40	Esophageal squamous(21;0.0137)					AAATATACTAAAAAGCATCCA	0.338000													4	48					0	0	0.150653	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73067273	73067273	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:73067273G>T	ENST00000263674.3	+	6	4067	c.3717G>T	c.(3715-3717)gaG>gaT	p.E1239D		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	1239	DH.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						TCCTGCTGGAGGCGCAGCGGA	0.637000													6	28					0.00116845	0.00126914	0.217242	1	0
MEGF8	1954	broad.mit.edu	37	19	42875540	42875540	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:42875540A>T	ENST00000334370.4	+	40	7609	c.6974A>T	c.(6973-6975)cAg>cTg	p.Q2325L	MEGF8_ENST00000378073.4_Intron|MEGF8_ENST00000251268.6_Missense_Mutation_p.Q2392L	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2392						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				TGTAACGAGCAGGATGGGACG	0.602000													5	33					0	0	0.184627	0	0
OR10P1	121130	broad.mit.edu	37	12	56031201	56031201	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:56031201C>T	ENST00000309675.2	+	1	558	c.526C>T	c.(526-528)Ccg>Tcg	p.P176S		NM_206899.1	NP_996782.1	Q8NGE3	O10P1_HUMAN	olfactory receptor, family 10, subfamily P, member 1	176					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(4)|large_intestine(3)|lung(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	26						CCCGATCATCCCGCACTTTCT	0.562000													34	64					0	0	0.796494	0	0
OR14A16	284532	broad.mit.edu	37	1	247978926	247978926	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:247978926C>A	ENST00000357627.1	-	1	105	c.106G>T	c.(106-108)Gcc>Tcc	p.A36S		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	36					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						CCCATCAGGGCACACAAATAA	0.373000													24	43					6.44725e-10	8.82486e-10	0.624587	1	0
CD38	952	broad.mit.edu	37	4	15780059	15780059	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:15780059C>A	ENST00000226279.2	+	1	159	c.22C>A	c.(22-24)Ccg>Acg	p.P8T		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	8					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						CGAGTTCAGCCCGGTGTCCGG	0.642000													4	63					0.000602214	0.000662436	0.184627	1	0
SSTR1	6751	broad.mit.edu	37	14	38679184	38679184	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:38679184G>T	ENST00000267377.2	+	3	1207	c.590G>T	c.(589-591)cGc>cTc	p.R197L		NM_001049.2	NP_001040.1	P30872	SSR1_HUMAN	somatostatin receptor 1	197					digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GTCTTCTCTCGCACCGCGGCC	0.632000													21	27					5.26018e-13	7.87725e-13	0.608945	1	0
NFIC	4782	broad.mit.edu	37	19	3381910	3381910	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:3381910G>T	ENST00000589123.1	+	2	324	c.204G>T	c.(202-204)ctG>ctT	p.L68L	NFIC_ENST00000346156.5_Silent_p.L68L|NFIC_ENST00000590282.1_Silent_p.L77L|NFIC_ENST00000341919.3_Silent_p.L77L|NFIC_ENST00000586919.1_Silent_p.L68L|NFIC_ENST00000443272.2_Silent_p.L77L|NFIC_ENST00000395111.3_Silent_p.L68L	NM_001245005.1|NM_205843.2	NP_001231934.1|NP_995315.1	P08651	NFIC_HUMAN	nuclear factor I/C (CCAAT-binding transcription factor)	77					DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		CGCGGCTGCTGGCCAAGCTGC	0.672000													33	32					3.93418e-24	6.87913e-24	0.796494	1	0
MAB21L2	10586	broad.mit.edu	37	4	151505160	151505160	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:151505160T>A	ENST00000317605.4	+	1	2084	c.979T>A	c.(979-981)Ttt>Att	p.F327I	LRBA_ENST00000507224.1_Intron|LRBA_ENST00000510413.1_Intron|LRBA_ENST00000357115.3_Intron|LRBA_ENST00000535741.1_Intron	NM_006439.4	NP_006430.1	Q9Y586	MB212_HUMAN	mab-21-like 2 (C. elegans)	327					nervous system development	nucleus				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	21	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		CCTCGACCTCTTTCAGGGCAA	0.607000													11	11					0	0	0.361761	0	0
ENTHD1	150350	broad.mit.edu	37	22	40161345	40161345	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:40161345A>G	ENST00000325157.6	-	6	1352	c.1102T>C	c.(1102-1104)Tct>Cct	p.S368P		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	368										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					AATGAGGGAGAGAGACAGAGT	0.418000													16	39					0	0	0.520397	0	0
NPY5R	4889	broad.mit.edu	37	4	164271630	164271630	+	Nonsense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:164271630A>T	ENST00000515560.1	+	4	1727	c.205A>T	c.(205-207)Aag>Tag	p.K69*	NPY5R_ENST00000338566.3_Nonsense_Mutation_p.K69*|NPY5R_ENST00000506953.1_Nonsense_Mutation_p.K69*			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	69					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				TCTCATGAAAAAGCGTAATCA	0.393000													21	140					0	0	0.608945	0	0
EOMES	8320	broad.mit.edu	37	3	27758988	27758988	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:27758988A>C	ENST00000295743.4	-	6	1837	c.1634T>G	c.(1633-1635)tTg>tGg	p.L545W	EOMES_ENST00000449599.1_Missense_Mutation_p.L564W|EOMES_ENST00000537516.1_Missense_Mutation_p.L269W			O95936	EOMES_HUMAN	eomesodermin	545					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						ATATGGGAGCAATGTGCTAGA	0.532000													43	47					0	0	0.834066	0	0
ERBB3	2065	broad.mit.edu	37	12	56495712	56495712	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:56495712A>T	ENST00000267101.3	+	28	4342	c.3902A>T	c.(3901-3903)cAg>cTg	p.Q1301L	ERBB3_ENST00000549832.1_Missense_Mutation_p.Q421L|ERBB3_ENST00000553131.1_Missense_Mutation_p.Q542L|RP11-603J24.9_ENST00000548861.1_Intron|ERBB3_ENST00000450146.2_Missense_Mutation_p.Q658L|ERBB3_ENST00000415288.2_Missense_Mutation_p.Q1242L	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	1301					cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			CCTGGACATCAGGCCCCCCAT	0.537000													54	94					0	0	0.870114	0	0
ATP8A2	51761	broad.mit.edu	37	13	26163785	26163785	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:26163785G>T	ENST00000381655.2	+	24	2301	c.2159G>T	c.(2158-2160)cGa>cTa	p.R720L	ATP8A2_ENST00000255283.8_Missense_Mutation_p.R680L|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	680					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TATTCCTGCCGATTGGTATCG	0.388000													22	42					3.08376e-08	4.02085e-08	0.654019	1	0
ZDHHC15	158866	broad.mit.edu	37	X	74742846	74742846	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:74742846C>A	ENST00000541184.1	-	1	491	c.14G>T	c.(13-15)tGg>tTg	p.W5L	ZDHHC15_ENST00000373361.3_Missense_Mutation_p.W5L|ZDHHC15_ENST00000373367.3_Missense_Mutation_p.W5L	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	5						integral to membrane	zinc ion binding	p.W5*(1)		central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						AGCCATCTTCCAGCCTCGCCG	0.662000													8	7					5.18039e-06	6.16956e-06	0.278610	1	0
NUMA1	4926	broad.mit.edu	37	11	71726319	71726319	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:71726319G>A	ENST00000393695.3	-	15	2561	c.2230C>T	c.(2230-2232)Cga>Tga	p.R744*	RP11-849H4.4_ENST00000502284.1_RNA|NUMA1_ENST00000358965.6_Nonsense_Mutation_p.R744*|NUMA1_ENST00000351960.6_Intron	NM_006185.2	NP_006176.2	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	744					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(12)|lung(20)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	65						ACCAGGCTTCGGGTCTCTGCC	0.602000			T	RARA	APL								8	92					0	0	0.278610	0	0
TTC37	9652	broad.mit.edu	37	5	94872822	94872822	+	Silent	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:94872822T>A	ENST00000358746.2	-	9	865	c.567A>T	c.(565-567)gcA>gcT	p.A189A		NM_014639.3	NP_055454.1	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	189							binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(13)|liver(1)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	47						ATAATCCCAGTGCATTCTCAA	0.294000													7	50					0	0	0.278610	0	0
ZNF608	57507	broad.mit.edu	37	5	123980334	123980334	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:123980334C>T	ENST00000306315.5	-	5	4161	c.3726G>A	c.(3724-3726)tgG>tgA	p.W1242*	ZNF608_ENST00000504926.1_Nonsense_Mutation_p.W815*	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1242						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		CATAATGATGCCATGTTCTTG	0.308000													6	16					0	0	0.217242	0	0
KRT75	9119	broad.mit.edu	37	12	52827729	52827729	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:52827729G>T	ENST00000252245.5	-	1	580	c.360C>A	c.(358-360)ggC>ggA	p.G120G		NM_004693.2	NP_004684.2	O95678	K2C75_HUMAN	keratin 75	120	Gly-rich.|Head.					keratin filament	structural molecule activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(10)|prostate(1)|skin(1)	28				BRCA - Breast invasive adenocarcinoma(357;0.192)		CCTCTTGGATGCCTCCAGGGG	0.612000													32	47					2.70662e-09	3.65515e-09	0.740014	1	0
SETD5	55209	broad.mit.edu	37	3	9517226	9517226	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:9517226C>T	ENST00000402466.1	+	24	4254	c.3486C>T	c.(3484-3486)tcC>tcT	p.S1162S	SETD5_ENST00000407969.1_Silent_p.S1279S|SETD5_ENST00000302463.6_Silent_p.S1162S|SETD5_ENST00000402198.1_Silent_p.S1260S|SETD5_ENST00000406341.1_Silent_p.S1260S			Q9C0A6	SETD5_HUMAN	SET domain containing 5	1260	Ser-rich.									NS(2)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(11)|ovary(3)|prostate(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(99;0.227)			OV - Ovarian serous cystadenocarcinoma(96;0.112)		AGAGTTCCTCCCCCTTCAGAG	0.512000													19	28					0	0	0.592651	0	0
SULT4A1	25830	broad.mit.edu	37	22	44237700	44237700	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:44237700C>T	ENST00000330884.4	-	2	402	c.282G>A	c.(280-282)ccG>ccA	p.P94P	SULT4A1_ENST00000540422.1_Intron|SULT4A1_ENST00000249130.5_Silent_p.P94P	NM_014351.3	NP_055166.1	Q9BR01	ST4A1_HUMAN	sulfotransferase family 4A, member 1	94					3'-phosphoadenosine 5'-phosphosulfate metabolic process|steroid metabolic process|xenobiotic metabolic process	cytosol	sulfotransferase activity			kidney(1)|large_intestine(3)|lung(4)|ovary(1)	9		Ovarian(80;0.024)|all_neural(38;0.0416)		Colorectal(1;0.00242)|READ - Rectum adenocarcinoma(1;0.0419)		TGTCCAGGCCCGGCTGTGGGT	0.582000													15	31					0	0	0.500413	0	0
C16orf3	750	broad.mit.edu	37	16	90095617	90095617	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:90095617G>T	ENST00000408886.2	-	1	692	c.134C>A	c.(133-135)gCc>gAc	p.A45D	GAS8_ENST00000536122.1_Intron|GAS8_ENST00000540721.1_Intron|GAS8_ENST00000268699.4_Intron	NM_001214.3	NP_001205.3	O95177	CP003_HUMAN	chromosome 16 open reading frame 3	45										large_intestine(1)|lung(2)|prostate(1)	4		all_cancers(9;9.01e-08)|Hepatocellular(780;0.000325)|Lung NSC(15;0.0104)|all_lung(18;0.0239)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		tacggggcaggctacggggca	0.677000													6	16					8.12818e-05	9.22618e-05	0.248553	1	0
ZNF792	126375	broad.mit.edu	37	19	35450390	35450390	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:35450390C>A	ENST00000404801.1	-	4	755	c.369G>T	c.(367-369)gaG>gaT	p.E123D	ZNF792_ENST00000605484.1_Missense_Mutation_p.E56D	NM_175872.4	NP_787068.3	Q3KQV3	ZN792_HUMAN	zinc finger protein 792	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(5)	12	all_lung(56;4.18e-08)|Lung NSC(56;6.62e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACAGAGTTGCCTCGGGACTCC	0.502000													37	47					2.20474e-14	3.41142e-14	0.788014	1	0
TNIP2	79155	broad.mit.edu	37	4	2746465	2746465	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:2746465G>C	ENST00000510267.1	-	4	971	c.544C>G	c.(544-546)Cgg>Ggg	p.R182G	TNIP2_ENST00000503235.1_Intron|TNIP2_ENST00000505186.1_5'UTR|TNIP2_ENST00000315423.7_Missense_Mutation_p.R289G	NM_001161527.1	NP_001154999.1	Q8NFZ5	TNIP2_HUMAN	TNFAIP3 interacting protein 2	289						cytosol	protein binding			breast(2)|central_nervous_system(1)|large_intestine(4)|lung(6)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCAGCATCCCGGGCCGTCCTG	0.617000													6	40					0	0	0.217242	0	0
USH2A	7399	broad.mit.edu	37	1	216373105	216373105	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:216373105G>T	ENST00000366943.2	-	17	4061	c.3675C>A	c.(3673-3675)agC>agA	p.S1225R	USH2A_ENST00000366942.3_Missense_Mutation_p.S1225R|RP5-1099E6.3_ENST00000420867.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.S1225R			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1225	Fibronectin type-III 2.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AACAGCCCCCGCTAGTACACG	0.493000										HNSCC(13;0.011)			7	56					8.12818e-05	9.22618e-05	0.248553	1	0
TULP4	56995	broad.mit.edu	37	6	158924188	158924188	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:158924188C>T	ENST00000367097.3	+	13	4850	c.3493C>T	c.(3493-3495)Cga>Tga	p.R1165*	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	1165					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity	p.R1165*(1)		endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		GGACGTGTCCCGACTGCCCTT	0.557000													23	87					0	0	0.667858	0	0
LTBP2	4053	broad.mit.edu	37	14	74975651	74975651	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:74975651C>T	ENST00000261978.4	-	23	3794	c.3408G>A	c.(3406-3408)gtG>gtA	p.V1136V	LTBP2_ENST00000556690.1_Silent_p.V1136V	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	1136	Cys-rich.|EGF-like 11; calcium-binding (Potential).				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CACATTCATCCACATCTGCAG	0.622000													17	59					0	0	0.500413	0	0
JUN	3725	broad.mit.edu	37	1	59248487	59248487	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:59248487C>A	ENST00000371222.2	-	1	1298	c.256G>T	c.(256-258)Ggg>Tgg	p.G86W		NM_002228.3	NP_002219.1	P05412	JUN_HUMAN	jun proto-oncogene	86					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation by host of viral transcription|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|SMAD protein import into nucleus|SMAD protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway		R-SMAD binding|Rho GTPase activator activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|kidney(2)|lung(5)|skin(1)	10	all_cancers(7;8.55e-07)				Arsenic trioxide(DB01169)|Irbesartan(DB01029)|Vinblastine(DB00570)	GTGATGTGCCCGTTGCTGGAC	0.677000			A		sarcoma								50	72					6.3091e-27	1.12265e-26	0.870114	1	0
OR52N4	390072	broad.mit.edu	37	11	5776004	5776004	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:5776004G>T	ENST00000317254.3	+	1	82	c.34G>T	c.(34-36)Gct>Tct	p.A12S	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CCTAATACCAGCTTCATTTAT	0.383000													29	26					1.88708e-17	3.10241e-17	0.729181	1	0
ANKRD33	341405	broad.mit.edu	37	12	52282850	52282850	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:52282850G>T	ENST00000301190.6	+	3	623		c.e3-1		ANKRD33_ENST00000538991.1_Intron|ANKRD33_ENST00000340970.4_Intron|ANKRD33_ENST00000547119.1_Intron	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33											endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		CCCTCCCTCAGACAGGCCTCA	0.612000													12	42					7.03913e-09	9.35972e-09	0.411799	1	0
SHANK1	50944	broad.mit.edu	37	19	51165488	51165488	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:51165488G>T	ENST00000293441.1	-	23	6238	c.6220C>A	c.(6220-6222)Cgc>Agc	p.R2074S	SHANK1_ENST00000391814.1_Missense_Mutation_p.R2082S|SHANK1_ENST00000391813.1_Missense_Mutation_p.R1461S|SHANK1_ENST00000359082.3_Missense_Mutation_p.R2065S|SYT3_ENST00000544769.1_Intron	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2074					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		GAGAGGGAGCGCGAGGCCCCT	0.682000													7	16					7.48243e-07	9.21969e-07	0.335167	1	0
OR14A16	284532	broad.mit.edu	37	1	247978659	247978659	+	Missense_Mutation	SNP	A	A	T	rs139200041	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:247978659A>T	ENST00000357627.1	-	1	372	c.373T>A	c.(373-375)Tgt>Agt	p.C125S		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	125					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						AGAGGGTGACATATAGCAGTA	0.502000													40	88					0	0	0.827153	0	0
WWC1	23286	broad.mit.edu	37	5	167850742	167850742	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:167850742G>T	ENST00000265293.4	+	11	1981	c.1479G>T	c.(1477-1479)cgG>cgT	p.R493R	WWC1_ENST00000521089.1_Silent_p.R493R	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	493					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CCGGCTTCCGGCCCTCAGGCT	0.632000													7	27					0.00198382	0.00213941	0.248553	1	0
METTL20	254013	broad.mit.edu	37	12	31819092	31819092	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:31819092C>T	ENST00000357721.3	+	3	601	c.386C>T	c.(385-387)aCa>aTa	p.T129I	METTL20_ENST00000538391.1_Intron|METTL20_ENST00000538463.1_Missense_Mutation_p.T129I|METTL20_ENST00000412352.2_Missense_Mutation_p.T129I|METTL20_ENST00000395763.3_Missense_Mutation_p.T129I	NM_001135863.1	NP_001129335.1	Q8IXQ9	MET20_HUMAN	methyltransferase like 20	129						cytoplasm	protein methyltransferase activity			lung(2)|stomach(1)	3						TGTGGAGCTACAGCTATTGCT	0.373000													9	80					0	0	0.335167	0	0
CPAMD8	27151	broad.mit.edu	37	19	17091417	17091417	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:17091417C>T	ENST00000443236.1	-	14	1647	c.1616G>A	c.(1615-1617)gGc>gAc	p.G539D	CPAMD8_ENST00000388925.4_Intron	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	492			D -> E (in dbSNP:rs3745335).			extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						CACAATATTGCCCCGTGCAGC	0.562000													3	52					0	0	0.115264	0	0
KCNK10	54207	broad.mit.edu	37	14	88729602	88729602	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:88729602C>A	ENST00000340700.5	-	2	782	c.331G>T	c.(331-333)Gaa>Taa	p.E111*	KCNK10_ENST00000312350.5_Nonsense_Mutation_p.E116*|KCNK10_ENST00000319231.5_Nonsense_Mutation_p.E116*	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	111					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						CGCAGGAATTCCGCCTTCTCC	0.582000													4	26					0.184627	0.188682	0.184627	1	0
PCDHB7	56129	broad.mit.edu	37	5	140552519	140552519	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:140552519G>T	ENST00000231137.3	+	1	277	c.103G>T	c.(103-105)Gtg>Ttg	p.V35L		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		35	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCGGTATTTTGTGGCGGAGGA	0.522000													15	45					2.31682e-05	2.69036e-05	0.479597	1	0
GNL1	2794	broad.mit.edu	37	6	30515033	30515033	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:30515033G>C	ENST00000376621.3	-	10	2267	c.1297C>G	c.(1297-1299)Cct>Gct	p.P433A		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	433					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						TGGGCGATAGGGTAGATCCCT	0.597000													12	175					0	0	0.411799	0	0
ZWILCH	55055	broad.mit.edu	37	15	66807973	66807973	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:66807973G>C	ENST00000307897.5	+	4	691	c.311G>C	c.(310-312)gGg>gCg	p.G104A	RPL4_ENST00000568588.1_Intron|ZWILCH_ENST00000446801.2_5'UTR|ZWILCH_ENST00000565960.1_3'UTR|RPL4_ENST00000564517.1_Intron|ZWILCH_ENST00000535141.2_5'UTR|ZWILCH_ENST00000565627.1_5'UTR	NM_017975.3	NP_060445.3	Q9H900	ZWILC_HUMAN	zwilch kinetochore protein	104					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(1)|lung(6)|ovary(1)	18						TTACCAGTTGGGAAGGCAAGG	0.398000													6	32					0	0	0.278610	0	0
RMND1	55005	broad.mit.edu	37	6	151744707	151744707	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:151744707T>C	ENST00000367303.4	-	7	1012	c.890A>G	c.(889-891)gAt>gGt	p.D297G	RMND1_ENST00000336451.3_Missense_Mutation_p.D86G	NM_017909.2	NP_060379.2	Q9NWS8	RMND1_HUMAN	required for meiotic nuclear division 1 homolog (S. cerevisiae)	297										central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.146)	OV - Ovarian serous cystadenocarcinoma(155;6.8e-11)		TAGAATGGCATCATCTAAATC	0.383000													17	130					0	0	0.539581	0	0
IL12RB2	3595	broad.mit.edu	37	1	67845698	67845698	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:67845698C>A	ENST00000262345.1	+	13	2387	c.1747C>A	c.(1747-1749)Cat>Aat	p.H583N	IL12RB2_ENST00000465396.1_3'UTR|IL12RB2_ENST00000371000.1_Missense_Mutation_p.H583N|IL12RB2_ENST00000544434.1_Missense_Mutation_p.H497N|IL12RB2_ENST00000541374.1_Missense_Mutation_p.H583N	NM_001559.2	NP_001550.1	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2	583	Fibronectin type-III 5.				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(21)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	45						CCAAAATTCACATCCAATAAA	0.433000													30	30					6.38683e-12	9.35601e-12	0.729181	1	0
HTR1A	3350	broad.mit.edu	37	5	63256904	63256904	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:63256904A>G	ENST00000323865.3	-	1	876	c.643T>C	c.(643-645)Tat>Cat	p.Y215H	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	215					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	ATGCGCCCATAGAGAACCAGC	0.582000													33	97					0	0	0.769981	0	0
DST	667	broad.mit.edu	37	6	56362216	56362216	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:56362216A>T	ENST00000370754.5	-	82	20090	c.20091T>A	c.(20089-20091)ggT>ggA	p.G6697G	DST_ENST00000244364.6_Silent_p.G4105G|DST_ENST00000312431.6_3'UTR|DST_ENST00000361203.3_Silent_p.G6408G|DST_ENST00000370769.4_Silent_p.G6519G|DST_ENST00000421834.2_Silent_p.G4431G|DST_ENST00000370788.2_Silent_p.G4322G|DST_ENST00000340834.4_5'UTR|DST_ENST00000446842.2_Silent_p.G6193G			Q03001	DYST_HUMAN	dystonin	6517					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTCCGGTAAACCTCCCAGCG	0.463000													4	37					0	0	0.184627	0	0
KRT34	3885	broad.mit.edu	37	17	39538444	39538444	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:39538444G>A	ENST00000394001.1	-	1	211	c.181C>T	c.(181-183)Cgg>Tgg	p.R61W		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	61	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				ACGCAGGGCCGGGAGGAGCAG	0.627000													31	83					0	0	0.729181	0	0
ANO1	55107	broad.mit.edu	37	11	69978181	69978181	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:69978181C>T	ENST00000355303.5	+	11	1559	c.1254C>T	c.(1252-1254)ctC>ctT	p.L418L	RP11-805J14.3_ENST00000530525.1_RNA|ANO1_ENST00000531349.1_Silent_p.L153L|ANO1_ENST00000530676.1_Silent_p.L302L|ANO1_ENST00000316296.5_Silent_p.L390L|ANO1_ENST00000398543.2_Silent_p.L302L|ANO1_ENST00000538023.1_Silent_p.L418L	NM_018043.5	NP_060513.5	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	418					multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(12)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)	29						TCATGGCCCTCTGGGGTAAGC	0.597000													10	1					0	0	0.411799	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923271	43923271	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:43923271C>T	ENST00000329196.5	+	1	1016	c.999C>T	c.(997-999)acC>acT	p.T333T	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	333						integral to membrane	aspartic-type endopeptidase activity										TGTGCGCAACCGTGATCATCT	0.652000													17	40					0	0	0.539581	0	0
HVCN1	84329	broad.mit.edu	37	12	111099122	111099122	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:111099122C>T	ENST00000356742.5	-	3	906	c.153G>A	c.(151-153)gaG>gaA	p.E51E	HVCN1_ENST00000548312.1_Silent_p.E51E|HVCN1_ENST00000242607.8_Silent_p.E51E|HVCN1_ENST00000439744.2_Silent_p.E31E			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	51	Poly-Glu.				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						cctcctcctcctcctcctctt	0.607000													21	32					0	0	0.592651	0	0
ESCO1	114799	broad.mit.edu	37	18	19146168	19146168	+	Splice_Site	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:19146168C>T	ENST00000269214.5	-	6	2583		c.e6-1			NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1						cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						GGAGCTGAACCTGTAATTTAA	0.299000													56	108					0	0	0.870114	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319267	21319267	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:21319267C>A	ENST00000583088.1	+	3	1508	c.613C>A	c.(613-615)Cgt>Agt	p.R205S	KCNJ12_ENST00000331718.5_Missense_Mutation_p.R205S	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GGTGGCCCTGCGTGACGGCAA	0.622000										Prostate(3;0.18)			4	34					0.00909568	0.00960364	0.150653	1	0
PLXNA4	91584	broad.mit.edu	37	7	131848984	131848984	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:131848984G>T	ENST00000359827.3	-	24	5379	c.4417C>A	c.(4417-4419)Ccc>Acc	p.P1473T	PLXNA4_ENST00000321063.4_Missense_Mutation_p.P1473T			Q9HCM2	PLXA4_HUMAN	plexin A4	1473						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCGTCAATGGGGCCCTTCTCC	0.587000													16	14					1.5739e-10	2.17896e-10	0.500413	1	0
PID1	55022	broad.mit.edu	37	2	229890413	229890413	+	Missense_Mutation	SNP	C	C	A	rs142605695	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:229890413C>A	ENST00000392054.3	-	4	1021	c.682G>T	c.(682-684)Ggg>Tgg	p.G228W	PID1_ENST00000354069.6_Missense_Mutation_p.G230W|PID1_ENST00000392055.3_Missense_Mutation_p.G197W|PID1_ENST00000482518.2_Intron|PID1_ENST00000409462.1_Missense_Mutation_p.G148W	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	230	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		TGGATCCGCCCGTCGCTCTTC	0.562000													5	71					0.0215528	0.0225596	0.217242	1	0
MYO7B	4648	broad.mit.edu	37	2	128390907	128390907	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:128390907A>G	ENST00000389524.4	+	39	5458	c.5405A>G	c.(5404-5406)cAc>cGc	p.H1802R	MYO7B_ENST00000428314.1_Missense_Mutation_p.H1801R|MYO7B_ENST00000409090.1_Missense_Mutation_p.H654R|MYO7B_ENST00000409816.2_Missense_Mutation_p.H1801R			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1801	FERM 2.|MyTH4 3.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CGCATCTGCCACAAGATCTAC	0.657000													3	22					0	0	0.150653	0	0
MYLK4	340156	broad.mit.edu	37	6	2679629	2679629	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:2679629C>A	ENST00000274643.7	-	9	1114	c.772G>T	c.(772-774)Gag>Tag	p.E258*	MYLK4_ENST00000268446.5_Nonsense_Mutation_p.E258*	NM_001012418.3	NP_001012418.2	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	258	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				TTCAGCTTCTCTCTGGGTTTG	0.423000													90	154					1.13049e-35	2.06008e-35	0.870114	1	0
OR8K1	390157	broad.mit.edu	37	11	56114150	56114150	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:56114150T>A	ENST00000279783.2	+	1	730	c.636T>A	c.(634-636)aaT>aaA	p.N212K		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					CAGGCTGTAATTTGCTCTTCT	0.373000										HNSCC(65;0.19)			37	31					0	0	0.804634	0	0
ABHD12	26090	broad.mit.edu	37	20	25300871	25300871	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:25300871G>C	ENST00000339157.5	-	4	778	c.506C>G	c.(505-507)cCt>cGt	p.P169R	ABHD12_ENST00000376542.3_Missense_Mutation_p.P169R	NM_001042472.2	NP_001035937.1	Q8N2K0	ABD12_HUMAN	abhydrolase domain containing 12	169						integral to membrane	acylglycerol lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(1)|skin(1)|urinary_tract(1)	12						CAGAATGATAGGGTGGCTGGA	0.562000													4	33					0	0	0.150653	0	0
EPHA7	2045	broad.mit.edu	37	6	93969119	93969119	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:93969119T>A	ENST00000369303.4	-	10	2061	c.1877A>T	c.(1876-1878)aAg>aTg	p.K626M		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	626						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		ATCTAGCTCCTTGGCGAATTG	0.428000													22	41					0	0	0.592651	0	0
ZNF681	148213	broad.mit.edu	37	19	23938261	23938261	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:23938261C>A	ENST00000402377.3	-	2	237	c.96G>T	c.(94-96)gtG>gtT	p.V32V	ZNF681_ENST00000395385.3_Intron	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	32	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TCTCTAACATCACATTCCTAT	0.358000													32	118					4.4194e-11	6.26168e-11	0.769981	1	0
RET	5979	broad.mit.edu	37	10	43606872	43606872	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:43606872G>T	ENST00000355710.3	+	7	1713	c.1481G>T	c.(1480-1482)aGg>aTg	p.R494M	RET_ENST00000340058.5_Missense_Mutation_p.R494M	NM_020975.4	NP_066124.1	P07949	RET_HUMAN	ret proto-oncogene	494					homophilic cell adhesion|positive regulation of metanephric glomerulus development|positive regulation of transcription, DNA-dependent|posterior midgut development	integral to membrane	ATP binding|calcium ion binding|transmembrane receptor protein tyrosine kinase activity		CCDC6/RET(4)|KIF5B/RET(79)	NS(2)|adrenal_gland(26)|breast(5)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|lung(27)|ovary(5)|prostate(3)|skin(1)|thyroid(504)|upper_aerodigestive_tract(1)|urinary_tract(1)	607		Ovarian(717;0.0423)			Sunitinib(DB01268)	CAGACCTCTAGGCAGGCCCAG	0.647000		1	"""T, Mis, N, F"""	"""H4, PRKAR1A, NCOA4, PCM1, GOLGA5, TRIM33, KTN1, TRIM27, HOOK3, KIF5B, CCDC6"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma, NSCLC"""	"""medullary thyroid,  papillary thyroid, pheochromocytoma"""	Hirschsprung disease		Multiple Endocrine Neoplasia, type 2B;Multiple Endocrine Neoplasia, type 2A;Familial Medullary Thyroid Carcinoma				11	23					0.000673444	0.000739444	0.361761	1	0
CNTN1	1272	broad.mit.edu	37	12	41408078	41408078	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:41408078G>C	ENST00000551295.2	+	18	2279	c.2162G>C	c.(2161-2163)aGa>aCa	p.R721T	CNTN1_ENST00000347616.1_Missense_Mutation_p.R721T|CNTN1_ENST00000348761.2_Missense_Mutation_p.R710T|CNTN1_ENST00000550305.1_3'UTR	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	721	Fibronectin type-III 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				GGAAGAAACAGAGAGCTGACC	0.398000													5	38					0	0	0.217242	0	0
IGLV2-11	28816	broad.mit.edu	37	22	23135477	23135477	+	RNA	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:23135477A>T	ENST00000390314.2	+	0	381																											GCTCATATGCAGGCAGCTACA	0.552000													31	101					0	0	0.740014	0	0
PLAA	9373	broad.mit.edu	37	9	26905785	26905785	+	Silent	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:26905785T>C	ENST00000397292.3	-	14	2529	c.2112A>G	c.(2110-2112)acA>acG	p.T704T		NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	704	PUL.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		TCAGGGCCAATGTAGCCAGAG	0.403000													7	38					0	0	0.278610	0	0
TAF7L	54457	broad.mit.edu	37	X	100537379	100537379	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:100537379A>G	ENST00000372907.3	-	5	611	c.600T>C	c.(598-600)acT>acC	p.T200T	TAF7L_ENST00000356784.1_Silent_p.T114T|TAF7L_ENST00000324762.6_Silent_p.T114T|TAF7L_ENST00000372905.2_Silent_p.T114T	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	200					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						TATTAGGATCAGTAGAGGCAG	0.443000													33	28					0	0	0.788014	0	0
EPS8L2	64787	broad.mit.edu	37	11	721659	721659	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:721659A>G	ENST00000533256.1	+	11	1238	c.863A>G	c.(862-864)aAg>aGg	p.K288R	EPS8L2_ENST00000530636.1_Missense_Mutation_p.K288R|EPS8L2_ENST00000318562.8_Missense_Mutation_p.K288R|EPS8L2_ENST00000526198.1_Missense_Mutation_p.K304R|AP006621.9_ENST00000527021.2_RNA			Q9H6S3	ES8L2_HUMAN	EPS8-like 2	288						cytoplasm				NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(2)|pancreas(1)|prostate(2)|soft_tissue(1)|urinary_tract(1)	13		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;4.37e-27)|Epithelial(43;2.81e-26)|OV - Ovarian serous cystadenocarcinoma(40;1.33e-20)|BRCA - Breast invasive adenocarcinoma(625;4.29e-05)|Lung(200;0.0582)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CAGCGGAAAAAGGGGAAGAAG	0.657000													3	38					0	0	0.150653	0	0
RBP3	5949	broad.mit.edu	37	10	48389088	48389088	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:48389088G>T	ENST00000224600.4	-	1	1903	c.1790C>A	c.(1789-1791)aCc>aAc	p.T597N		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	597	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GTCGATGAAGGTGAGGACCGG	0.672000													16	46					4.14922e-12	6.0929e-12	0.500413	1	0
PHOX2A	401	broad.mit.edu	37	11	71952179	71952179	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:71952179C>A	ENST00000298231.5	-	2	543	c.372G>T	c.(370-372)gcG>gcT	p.A124A	PHOX2A_ENST00000544057.1_5'UTR	NM_005169.3	NP_005160.2	O14813	PHX2A_HUMAN	paired-like homeobox 2a	124					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	5						CGATCTTGAGCGCCAGCTCCT	0.597000													7	30					1.06961e-07	1.37392e-07	0.278610	1	0
OR1L8	138881	broad.mit.edu	37	9	125330688	125330688	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:125330688C>T	ENST00000304865.2	-	1	150	c.69G>A	c.(67-69)gaG>gaA	p.E23E		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TCTTTTGGTCCTCAGGCCGGG	0.493000													8	31					0	0	0.278610	0	0
PCSK5	5125	broad.mit.edu	37	9	78682927	78682927	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:78682927C>G	ENST00000545128.1	+	6	1227	c.689C>G	c.(688-690)aCa>aGa	p.T230R	PCSK5_ENST00000376752.4_Missense_Mutation_p.T230R|PCSK5_ENST00000376767.3_Missense_Mutation_p.T230R	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	230	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TCGCACTGCACAGTCGGAATT	0.512000													20	56					0	0	0.557998	0	0
ZNF549	256051	broad.mit.edu	37	19	58042467	58042467	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:58042467A>T	ENST00000602149.1	+	2	211	c.63A>T	c.(61-63)aaA>aaT	p.K21N	ZNF549_ENST00000240719.3_Intron|ZNF549_ENST00000594943.1_Intron|ZNF549_ENST00000376233.3_Missense_Mutation_p.K21N			Q6P9A3	ZN549_HUMAN	zinc finger protein 549	21					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	21		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGTTTGTGAAACCATCACAGG	0.483000													9	62					0	0	0.361761	0	0
KRT13	3860	broad.mit.edu	37	17	39661353	39661353	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:39661353C>A	ENST00000246635.3	-	1	496	c.450G>T	c.(448-450)cgG>cgT	p.R150R	KRT13_ENST00000587544.1_Silent_p.R150R|KRT13_ENST00000336861.3_Silent_p.R150R	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	150	Linker 1.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				GGCTGTAGTCCCGCTCAGGGC	0.622000													33	42					2.08457e-15	3.29286e-15	0.750413	1	0
KIF13A	63971	broad.mit.edu	37	6	17809094	17809094	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:17809094T>A	ENST00000378814.5	-	18	2067	c.2068A>T	c.(2068-2070)Agg>Tgg	p.R690W	KIF13A_ENST00000259711.6_Missense_Mutation_p.R690W|KIF13A_ENST00000378816.5_Missense_Mutation_p.R690W|KIF13A_ENST00000378843.2_Missense_Mutation_p.R690W|KIF13A_ENST00000378826.2_Missense_Mutation_p.R690W	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	690					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TTTGCTTCCCTCACCAAGGTA	0.478000													5	28					0	0	0.184627	0	0
MKL1	57591	broad.mit.edu	37	22	40814546	40814546	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:40814546G>A	ENST00000396617.3	-	12	2486	c.1896C>T	c.(1894-1896)ccC>ccT	p.P632P	MKL1_ENST00000355630.3_Silent_p.P632P|MKL1_ENST00000402042.1_Silent_p.P582P|MKL1_ENST00000407029.1_Silent_p.P632P			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	632	Pro-rich.				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						GGACCGGCTCGGGCTCAGGCT	0.701000			T	RBM15	acute megakaryocytic leukemia								7	24					0	0	0.248553	0	0
ARPC1B	10095	broad.mit.edu	37	7	98988802	98988802	+	Splice_Site	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:98988802G>A	ENST00000451682.1	+	9	1018	c.707_splice	c.e9-1	p.V237_splice	ARPC1B_ENST00000252725.5_Splice_Site_p.V237_splice			O15143	ARC1B_HUMAN	actin related protein 2/3 complex, subunit 1B, 41kDa	237					cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cytoplasm	actin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(2)|lung(1)	11	all_cancers(62;3.49e-09)|all_epithelial(64;2.57e-10)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCCCCTCAGCGTCGCGACTCT	0.617000													3	16					0	0	0.150653	0	0
PCLO	27445	broad.mit.edu	37	7	82430869	82430869	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:82430869T>C	ENST00000333891.8	-	22	15309	c.14972A>G	c.(14971-14973)cAg>cGg	p.Q4991R		NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4914	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TACCCCTGGCTGTTTTACAGG	0.363000													18	34					0	0	0.624587	0	0
ZNF813	126017	broad.mit.edu	37	19	53994626	53994626	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:53994626G>A	ENST00000396403.4	+	4	1268	c.1140G>A	c.(1138-1140)gaG>gaA	p.E380E	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	380					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		ATACGGGAGAGAAACCTTATA	0.428000													62	67					0	0	0.870114	0	0
LRRC4C	57689	broad.mit.edu	37	11	40136824	40136824	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:40136824T>C	ENST00000278198.2	-	2	2982	c.1019A>G	c.(1018-1020)tAc>tGc	p.Y340C	LRRC4C_ENST00000530763.1_Missense_Mutation_p.Y340C|LRRC4C_ENST00000528697.1_Missense_Mutation_p.Y340C|LRRC4C_ENST00000527150.1_Missense_Mutation_p.Y340C			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	340	LRRCT.				regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				CTCTCCAATGTACCTCCCCTT	0.532000													6	38					0	0	0.217242	0	0
FREM1	158326	broad.mit.edu	37	9	14851557	14851557	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:14851557G>A	ENST00000380881.4	-	7	1695	c.880C>T	c.(880-882)Cag>Tag	p.Q294*	FREM1_ENST00000422223.2_Nonsense_Mutation_p.Q293*|FREM1_ENST00000380880.3_Nonsense_Mutation_p.Q293*			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	293					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TTTGGAATCTGATTCGGAATT	0.423000													29	77					0	0	0.788014	0	0
KIF21A	55605	broad.mit.edu	37	12	39726099	39726099	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:39726099C>A	ENST00000395670.3	-	21	3387	c.2968G>T	c.(2968-2970)Gag>Tag	p.E990*	KIF21A_ENST00000361961.3_Nonsense_Mutation_p.E977*|KIF21A_ENST00000544797.2_Nonsense_Mutation_p.E977*|KIF21A_ENST00000361418.5_Nonsense_Mutation_p.E990*|KIF21A_ENST00000541463.2_Nonsense_Mutation_p.E954*			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	990					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				GTCAGTGACTCCATCTCTTCA	0.358000													50	116					6.31075e-24	1.10029e-23	0.870114	1	0
VAMP3	9341	broad.mit.edu	37	1	7837301	7837301	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:7837301G>T	ENST00000054666.6	+	3	269	c.154G>T	c.(154-156)Gca>Tca	p.A52S	VAMP3_ENST00000470357.1_Missense_Mutation_p.A24S	NM_004781.3	NP_004772.1	Q15836	VAMP3_HUMAN	vesicle-associated membrane protein 3	52	v-SNARE coiled-coil homology.				cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CCGTGCAGACGCACTGCAGGC	0.463000													17	13					9.16793e-09	1.21105e-08	0.520397	1	0
OR10A3	26496	broad.mit.edu	37	11	7960514	7960514	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:7960514A>G	ENST00000360759.3	-	1	627	c.554T>C	c.(553-555)cTa>cCa	p.L185P		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CACAAGCTCTAGTACCGGGGG	0.433000													40	28					0	0	0.847076	0	0
LRRC45	201255	broad.mit.edu	37	17	79986492	79986492	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:79986492G>A	ENST00000306688.3	+	12	1583	c.1241G>A	c.(1240-1242)cGc>cAc	p.R414H		NM_144999.2	NP_659436.1	Q96CN5	LRC45_HUMAN	leucine rich repeat containing 45	414						centrosome				lung(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	5	all_neural(118;0.0878)|Ovarian(332;0.12)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0191)			CTTCCAGAGCGCCTGGACATG	0.662000													9	20					0	0	0.335167	0	0
CABYR	26256	broad.mit.edu	37	18	21735868	21735868	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:21735868G>A	ENST00000399481.2	+	2	261	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K	CABYR_ENST00000399499.1_Missense_Mutation_p.E135K|CABYR_ENST00000415309.2_Missense_Mutation_p.E135K|CABYR_ENST00000327201.6_Missense_Mutation_p.E37K|CABYR_ENST00000399496.3_Missense_Mutation_p.E135K|CABYR_ENST00000581397.1_Missense_Mutation_p.E135K			O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	135	RIIa.				ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					TGAGCAAACGGAAGCAGTTGG	0.493000													112	46					0	0	0.870114	0	0
SCAF11	9169	broad.mit.edu	37	12	46355595	46355595	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:46355595C>A	ENST00000369367.3	-	3	340	c.107G>T	c.(106-108)aGt>aTt	p.S36I	SCAF11_ENST00000395454.2_Missense_Mutation_p.S36I|SCAF11_ENST00000419565.2_Missense_Mutation_p.S36I|SCAF11_ENST00000395453.2_Missense_Mutation_p.S36I	NM_004719.2	NP_004710.2	Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	36					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GTCAGCCTCACTGTACAACAG	0.368000													26	48					3.17567e-06	3.80451e-06	0.729181	1	0
HDAC9	9734	broad.mit.edu	37	7	18624995	18624995	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:18624995C>A	ENST00000406451.3	+	3	264	c.114C>A	c.(112-114)gaC>gaA	p.D38E	HDAC9_ENST00000456174.2_Missense_Mutation_p.D7E|HDAC9_ENST00000417496.2_Missense_Mutation_p.D80E|HDAC9_ENST00000476135.1_3'UTR|HDAC9_ENST00000432645.2_Missense_Mutation_p.D38E|HDAC9_ENST00000401921.1_Missense_Mutation_p.D38E|HDAC9_ENST00000406072.1_Missense_Mutation_p.D66E|HDAC9_ENST00000428307.2_Missense_Mutation_p.D38E|HDAC9_ENST00000524023.1_Missense_Mutation_p.D7E|HDAC9_ENST00000405010.3_Missense_Mutation_p.D38E|HDAC9_ENST00000441542.2_Missense_Mutation_p.D38E	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	38					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CCGTGGTGGACCCTGTTGTCC	0.493000													7	88					8.12818e-05	9.22618e-05	0.248553	1	0
PRRC2C	23215	broad.mit.edu	37	1	171482185	171482185	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:171482185G>A	ENST00000367742.3	+	3	406	c.164G>A	c.(163-165)cGt>cAt	p.R55H	PRRC2C_ENST00000392078.3_Missense_Mutation_p.R55H|PRRC2C_ENST00000426496.2_Missense_Mutation_p.R53H|PRRC2C_ENST00000338920.4_Missense_Mutation_p.R53H|PRRC2C_ENST00000476522.1_3'UTR			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	53							protein C-terminus binding										ATTTCACGGCGTATGCCTCCA	0.408000													8	44					0	0	0.335167	0	0
DCC	1630	broad.mit.edu	37	18	51025789	51025789	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:51025789C>A	ENST00000442544.2	+	27	4636	c.4020C>A	c.(4018-4020)caC>caA	p.H1340Q	RP11-671P2.1_ENST00000582064.1_RNA|DCC_ENST00000581580.1_Missense_Mutation_p.H973Q	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1340					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GACCAACTCACCCACTCCGCA	0.527000													27	44					9.78306e-22	1.6767e-21	0.740014	1	0
PIK3CG	5294	broad.mit.edu	37	7	106508180	106508180	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:106508180G>T	ENST00000359195.3	+	2	484	c.174G>T	c.(172-174)ctG>ctT	p.L58L	PIK3CG_ENST00000496166.1_Silent_p.L58L|PIK3CG_ENST00000440650.2_Silent_p.L58L	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	58					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding	p.L58L(1)		breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						AAACGGCGCTGCTGCACGTGG	0.682000													4	24					0.00024832	0.000276165	0.150653	1	0
NOD2	64127	broad.mit.edu	37	16	50733449	50733449	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:50733449G>A	ENST00000300589.2	+	2	229	c.124G>A	c.(124-126)Gtc>Atc	p.V42I	NOD2_ENST00000526417.2_3'UTR	NM_022162.1	NP_071445.1	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain containing 2	42	CARD 1.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			cervix(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(30)|ovary(3)|skin(3)	52		all_cancers(37;0.0156)				GAGCCAGCTGGTCGAGCTGCT	0.602000													13	112					0	0	0.435327	0	0
CCDC63	160762	broad.mit.edu	37	12	111336756	111336756	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:111336756C>T	ENST00000308208.5	+	10	1411	c.1169C>T	c.(1168-1170)aCg>aTg	p.T390M	CCDC63_ENST00000545036.1_Missense_Mutation_p.T350M|CCDC63_ENST00000552694.1_Missense_Mutation_p.T311M	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	390										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						AGGAAGACCACGGAGGAGGCA	0.517000													8	47					0	0	0.278610	0	0
COL4A1	1282	broad.mit.edu	37	13	110822982	110822982	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:110822982C>T	ENST00000375820.4	-	42	3775	c.3654G>A	c.(3652-3654)caG>caA	p.Q1218Q		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1218	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCGGCTGTCCCTGGGGCCCCG	0.647000													7	15					0	0	0.307466	0	0
DOCK2	1794	broad.mit.edu	37	5	169494579	169494579	+	Missense_Mutation	SNP	G	G	A	rs148502872	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:169494579G>A	ENST00000256935.8	+	45	4613	c.4533G>A	c.(4531-4533)atG>atA	p.M1511I	DOCK2_ENST00000520908.1_Missense_Mutation_p.M1003I|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000540750.1_Missense_Mutation_p.M572I	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1511	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGATCCTGATGATGATAAACC	0.502000													10	59					0	0	0.361761	0	0
RGPD4	285190	broad.mit.edu	37	2	108487926	108487926	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:108487926C>G	ENST00000408999.3	+	20	3543	c.3466C>G	c.(3466-3468)Ctg>Gtg	p.L1156V	RGPD4_ENST00000354986.4_Missense_Mutation_p.L1156V	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1156	RanBD1 1.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AACACCAGAGCTGGCTGAAGA	0.453000													15	163					0	0	0.479597	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773003	140773003	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:140773003A>G	ENST00000398604.2	+	1	623	c.623A>G	c.(622-624)cAc>cGc	p.H208R	PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGGCTGCTCACCACCTGGTC	0.602000													10	22					0	0	0.387290	0	0
FOXN4	121643	broad.mit.edu	37	12	109723224	109723224	+	Silent	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:109723224G>C	ENST00000299162.5	-	8	890	c.786C>G	c.(784-786)tcC>tcG	p.S262S	FOXN4_ENST00000355216.1_Silent_p.S82S	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	262					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						AGCCCTTGCGGGAGGAGCCGC	0.602000													8	24					0	0	0.278610	0	0
IFT122	55764	broad.mit.edu	37	3	129195584	129195584	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:129195584T>C	ENST00000296266.3	+	12	1432	c.1240T>C	c.(1240-1242)Tat>Cat	p.Y414H	IFT122_ENST00000431818.2_Missense_Mutation_p.Y213H|IFT122_ENST00000348417.2_Missense_Mutation_p.Y363H|IFT122_ENST00000440957.2_Missense_Mutation_p.Y154H|IFT122_ENST00000349441.2_Missense_Mutation_p.Y252H|IFT122_ENST00000504021.1_Missense_Mutation_p.Y257H|IFT122_ENST00000347300.2_Missense_Mutation_p.Y304H|IFT122_ENST00000507564.1_Missense_Mutation_p.Y355H	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	363					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						CAAGGACCGCTATGCCTACAG	0.547000													6	45					0	0	0.217242	0	0
KLF4	9314	broad.mit.edu	37	9	110249369	110249369	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:110249369C>A	ENST00000374672.4	-	4	1677	c.1204G>T	c.(1204-1206)Ggc>Tgc	p.G402C		NM_004235.4	NP_004226.3	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	436	Pro-rich.				fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(5)|large_intestine(1)|lung(3)|pancreas(1)|prostate(2)	16						TTGCCGCAGCCCGCGTAATCA	0.597000													51	89					1.46357e-32	2.64317e-32	0.870114	1	0
JAKMIP2	9832	broad.mit.edu	37	5	147051255	147051255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:147051255G>A	ENST00000265272.5	-	2	582	c.115C>T	c.(115-117)Caa>Taa	p.Q39*	JAKMIP2_ENST00000333010.6_Intron|JAKMIP2_ENST00000507386.1_Nonsense_Mutation_p.Q39*	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	39						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACTTCTCTTGATGCAGCTCT	0.557000													4	15					0	0	0.150653	0	0
AC008268.2	0	broad.mit.edu	37	2	96458294	96458294	+	RNA	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:96458294G>A	ENST00000471661.1	+	0	312																											CCAAGAGCTGGGTGAGTGATG	0.587000													3	25					0	0	0.150653	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590506	140590506	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:140590506C>T	ENST00000239450.2	+	1	2216	c.2027C>T	c.(2026-2028)gCg>gTg	p.A676V	PCDHB12_ENST00000541609.1_Missense_Mutation_p.A339V	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		676					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCCGGAGGCGGCCCCGGCC	0.687000													14	91					0	0	0.575678	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12884858	12884858	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:12884858C>A	ENST00000535591.1	-	4	1448	c.1253G>T	c.(1252-1254)tGc>tTc	p.C418F		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	418										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						ATGGTCAGGGCAGTTGTCAGT	0.478000													26	57					2.65835e-16	4.27739e-16	0.717897	1	0
GPC1	2817	broad.mit.edu	37	2	241404605	241404605	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:241404605T>G	ENST00000264039.2	+	7	1494	c.1246T>G	c.(1246-1248)Tgg>Ggg	p.W416G		NM_002081.2	NP_002072.2	P35052	GPC1_HUMAN	glypican 1	416					axon guidance	anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	9		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;4.51e-33)|all cancers(36;1.74e-30)|OV - Ovarian serous cystadenocarcinoma(60;4.73e-15)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;9.1e-06)|Colorectal(34;0.000487)|Lung(119;0.0013)|LUSC - Lung squamous cell carcinoma(224;0.0154)|COAD - Colon adenocarcinoma(134;0.0194)|READ - Rectum adenocarcinoma(96;0.0949)		TGACCGCTGCTGGAACGGGAT	0.662000													3	10					0	0	0.115264	0	0
GRK6	2870	broad.mit.edu	37	5	176867988	176867988	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:176867988G>T	ENST00000355472.5	+	15	1779	c.1611G>T	c.(1609-1611)ctG>ctT	p.L537L	GRK6_ENST00000528793.1_Silent_p.L537L|GRK6_ENST00000355958.5_Silent_p.L537L|GRK6_ENST00000393576.3_Silent_p.L503L|PRR7-AS1_ENST00000425316.3_RNA	NM_001004106.2|NM_002082.3	NP_001004106.1|NP_002073.2	P43250	GRK6_HUMAN	G protein-coupled receptor kinase 6	537					regulation of G-protein coupled receptor protein signaling pathway	membrane	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(5)|stomach(1)	25	all_cancers(89;1.15e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCCAGACCTGGACTGGAAGG	0.602000													3	15					0.184627	0.188682	0.184627	1	0
ZSCAN4	201516	broad.mit.edu	37	19	58189929	58189929	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:58189929G>A	ENST00000318203.5	+	5	1655	c.958G>A	c.(958-960)Gtc>Atc	p.V320I		NM_152677.2	NP_689890.1	Q8NAM6	ZSCA4_HUMAN	zinc finger and SCAN domain containing 4	320					telomere maintenance via telomere lengthening|viral reproduction	nuclear chromosome, telomeric region	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|large_intestine(5)|liver(2)|lung(17)|ovary(1)|skin(1)|stomach(1)	30		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATGCCCCAAGGTCTTTAAGTA	0.438000													55	59					0	0	0.870114	0	0
IDO1	3620	broad.mit.edu	37	8	39782849	39782849	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:39782849G>T	ENST00000518237.1	+	9	1454	c.815G>T	c.(814-816)tGc>tTc	p.C272F	RP11-44K6.3_ENST00000517623.1_RNA|IDO1_ENST00000522495.1_Missense_Mutation_p.C272F	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	272					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	GTCTTTCAGTGCTTTGACGTC	0.488000													11	9					2.80697e-09	3.76545e-09	0.387290	1	0
BMPR2	659	broad.mit.edu	37	2	203329636	203329636	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:203329636T>A	ENST00000374580.4	+	2	720	c.181T>A	c.(181-183)Tcg>Acg	p.S61T	BMPR2_ENST00000479069.1_3'UTR|BMPR2_ENST00000374574.2_Missense_Mutation_p.S61T	NM_001204.6	NP_001195.2	Q13873	BMPR2_HUMAN	bone morphogenetic protein receptor, type II (serine/threonine kinase)	61					anterior/posterior pattern formation|BMP signaling pathway|cellular response to starvation|lung alveolus development|mesoderm formation|negative regulation of cell growth|negative regulation of systemic arterial blood pressure|negative regulation of vasoconstriction|positive regulation of BMP signaling pathway|positive regulation of bone mineralization|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of epithelial cell migration|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|regulation of lung blood pressure|transcription from RNA polymerase II promoter|vascular endothelial growth factor receptor signaling pathway	integral to plasma membrane	ATP binding|metal ion binding|transforming growth factor beta receptor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(11)|lung(7)|ovary(4)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(2)	42						AATATTATGCTCGAAAGGTAG	0.418000													24	97					0	0	0.681144	0	0
CCDC22	28952	broad.mit.edu	37	X	49093593	49093593	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:49093593A>T	ENST00000376227.3	+	2	261	c.91A>T	c.(91-93)Act>Tct	p.T31S	CCDC22_ENST00000496651.1_3'UTR	NM_014008.3	NP_054727.1	O60826	CCD22_HUMAN	coiled-coil domain containing 22	31										NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	18						CGCCTTCACCACTGAGCTGGT	0.612000													18	13					0	0	0.557998	0	0
C8orf74	203076	broad.mit.edu	37	8	10555351	10555351	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:10555351T>A	ENST00000304519.5	+	3	513	c.484T>A	c.(484-486)Tgg>Agg	p.W162R	RP1L1_ENST00000329335.3_Intron	NM_001040032.1	NP_001035121.1	Q6P047	CH074_HUMAN	chromosome 8 open reading frame 74	162										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|urinary_tract(1)	13				COAD - Colon adenocarcinoma(149;0.0811)		CAGGGACTTGTGGATCCACGA	0.682000													21	20					0	0	0.575678	0	0
SLFN5	162394	broad.mit.edu	37	17	33591385	33591385	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:33591385C>G	ENST00000299977.4	+	4	1470	c.1322C>G	c.(1321-1323)gCt>gGt	p.A441G	SLFN5_ENST00000542451.1_Intron	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	441					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		ATCTGTGATGCTCTTCTAATT	0.443000													30	76					0	0	0.740014	0	0
TRIM67	440730	broad.mit.edu	37	1	231339744	231339744	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:231339744G>T	ENST00000444294.3	+	6	2518	c.1660G>T	c.(1660-1662)Ggg>Tgg	p.G554W	TRIM67_ENST00000449018.3_Missense_Mutation_p.G494W|TRIM67_ENST00000366653.5_Missense_Mutation_p.G556W|TRIM67_ENST00000366652.2_Missense_Mutation_p.G556W	NM_001004342.3	NP_001004342.3	Q6ZTA4	TRI67_HUMAN	tripartite motif containing 67	556	Fibronectin type-III.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Breast(184;0.0871)	all_cancers(173;0.189)|Prostate(94;0.167)				CGACGGTGCCGGGGGACAGTT	0.632000													8	38					3.09899e-07	3.91417e-07	0.307466	1	0
RNFT2	84900	broad.mit.edu	37	12	117191859	117191859	+	Silent	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:117191859A>C	ENST00000257575.4	+	5	854	c.621A>C	c.(619-621)tcA>tcC	p.S207S	RNFT2_ENST00000319176.7_Silent_p.S207S|RNFT2_ENST00000392549.2_Silent_p.S207S|RNFT2_ENST00000407967.3_Silent_p.S207S			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	207						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		AACAGGTCTCACTGAAGGTGA	0.557000													7	63					0	0	0.307466	0	0
TTN	7273	broad.mit.edu	37	2	179654843	179654843	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:179654843C>A	ENST00000589042.1	-	12	2025		c.e12-1		TTN_ENST00000591111.1_Splice_Site|TTN_ENST00000360870.5_Splice_Site|TTN_ENST00000359218.5_Splice_Site|TTN_ENST00000460472.2_Splice_Site|TTN_ENST00000342992.6_Splice_Site|TTN_ENST00000342175.6_Splice_Site	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTTCATTATCTGATCATACA	0.308000													17	25					5.03518e-11	7.1009e-11	0.557998	1	0
MUC5B	727897	broad.mit.edu	37	11	1247853	1247853	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:1247853C>A	ENST00000447027.1	+	4	266	c.208C>A	c.(208-210)Ccg>Acg	p.P70T	MUC5B_ENST00000529681.1_Missense_Mutation_p.P70T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	70					cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGCCCTGAACCCGGCGCACAA	0.647000													6	5					0.00116845	0.00126914	0.217242	1	0
TP53	7157	broad.mit.edu	37	17	7577157	7577157	+	Splice_Site	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:7577157T>A	ENST00000420246.2	-	8	915		c.e8-2		TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(11)|p.0?(8)|p.E258fs*71(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATTACCACTACTCAGGATA	0.512000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			3	7					0	0	0.115264	0	0
FOXN4	121643	broad.mit.edu	37	12	109723225	109723225	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:109723225G>T	ENST00000299162.5	-	8	889	c.785C>A	c.(784-786)tCc>tAc	p.S262Y	FOXN4_ENST00000355216.1_Missense_Mutation_p.S82Y	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	262					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						GCCCTTGCGGGAGGAGCCGCT	0.602000													9	24					0.00448238	0.00479972	0.307466	1	0
OR2V2	285659	broad.mit.edu	37	5	180582280	180582280	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:180582280G>T	ENST00000328275.1	+	1	338	c.338G>T	c.(337-339)gGg>gTg	p.G113V		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGATCTGAGGGGCTCTTGCTG	0.517000													18	53					9.7654e-05	0.000110638	0.557998	1	0
SNAP29	9342	broad.mit.edu	37	22	21237785	21237785	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:21237785G>T	ENST00000215730.6	+	4	675	c.547G>T	c.(547-549)Gcc>Tcc	p.A183S		NM_004782.3	NP_004773.1	O95721	SNP29_HUMAN	synaptosomal-associated protein, 29kDa	183					cellular membrane fusion|exocytosis|protein transport|vesicle targeting	cell junction|cytoplasm|nucleus|synapse|synaptosome	SNAP receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(1)|upper_aerodigestive_tract(1)	9	all_cancers(11;2.77e-25)|all_epithelial(7;8.92e-24)|Lung NSC(8;1.49e-15)|all_lung(8;2.54e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000592)|Lung(15;0.0117)			GGCTGGTTCTGCCATGAGTAC	0.498000													5	128					8.12818e-05	9.22618e-05	0.248553	1	0
NF1	4763	broad.mit.edu	37	17	29541557	29541557	+	Nonsense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:29541557T>A	ENST00000358273.4	+	13	1864	c.1481T>A	c.(1480-1482)tTg>tAg	p.L494*	NF1_ENST00000431387.4_Nonsense_Mutation_p.L494*|NF1_ENST00000356175.3_Nonsense_Mutation_p.L494*	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	494					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(5)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TATCTTCTCTTGTCCATGGTG	0.303000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			22	35					0	0	0.592651	0	0
ZNF496	84838	broad.mit.edu	37	1	247492125	247492125	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:247492125C>A	ENST00000294753.4	-	4	898	c.434G>T	c.(433-435)aGc>aTc	p.S145I	ZNF496_ENST00000366498.2_Missense_Mutation_p.S145I	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	145					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			GTCCAGAGGGCTGTCCCCATC	0.602000													21	131					2.21704e-12	3.27948e-12	0.639603	1	0
NEK6	10783	broad.mit.edu	37	9	127101941	127101941	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:127101941C>A	ENST00000373600.3	+	9	1031	c.816C>A	c.(814-816)taC>taA	p.Y272*	NEK6_ENST00000545174.1_Nonsense_Mutation_p.Y238*|NEK6_ENST00000546191.1_Nonsense_Mutation_p.Y238*|NEK6_ENST00000394199.2_Nonsense_Mutation_p.Y272*|NEK6_ENST00000320246.5_Nonsense_Mutation_p.Y238*|NEK6_ENST00000373603.1_Nonsense_Mutation_p.Y238*|NEK6_ENST00000540326.1_Nonsense_Mutation_p.Y256*|NEK6_ENST00000539416.1_Nonsense_Mutation_p.Y263*	NM_001145001.2	NP_001138473.1	Q9HC98	NEK6_HUMAN	NIMA-related kinase 6	238	Protein kinase.				apoptosis|cell division|chromosome segregation|mitosis|peptidyl-serine phosphorylation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of mitotic metaphase/anaphase transition	cytoplasm|nucleus	ATP binding|kinesin binding|magnesium ion binding|protein kinase binding|protein serine/threonine kinase activity|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15						GTCTGCTGTACGAGGTGAGTC	0.587000													13	34					2.27111e-07	2.87452e-07	0.411799	1	0
OR6C76	390326	broad.mit.edu	37	12	55820361	55820361	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:55820361G>T	ENST00000328314.3	+	1	324	c.324G>T	c.(322-324)gaG>gaT	p.E108D		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCTCAACGGAGTTTTTCCTCC	0.403000													53	126					7.77372e-23	1.33992e-22	0.870114	1	0
C1QB	713	broad.mit.edu	37	1	22987407	22987407	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:22987407C>T	ENST00000509305.1	+	3	630	c.284C>T	c.(283-285)cCt>cTt	p.P95L	C1QB_ENST00000314933.6_Missense_Mutation_p.P97L			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	97	Collagen-like 2.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCCATGGGCCCTAAAGGTGGC	0.617000													4	55					0	0	0.150653	0	0
HK1	3098	broad.mit.edu	37	10	71103608	71103608	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:71103608G>A	ENST00000448642.2	+	7	583	c.194G>A	c.(193-195)cGg>cAg	p.R65Q	HK1_ENST00000494253.1_3'UTR|HK1_ENST00000360289.2_Missense_Mutation_p.R18Q|HK1_ENST00000404387.2_Missense_Mutation_p.R34Q|HK1_ENST00000359426.6_Missense_Mutation_p.R30Q|HK1_ENST00000298649.3_Missense_Mutation_p.R29Q			P19367	HXK1_HUMAN	hexokinase 1	30	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						TATGCCATGCGGCTCTCCGAT	0.532000													38	93					0	0	0.870114	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140774465	140774465	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:140774465G>T	ENST00000398604.2	+	1	2085	c.2085G>T	c.(2083-2085)gtG>gtT	p.V695V	PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCTCGTGGTGGCAGTGGCTG	0.607000													6	12					0.00116845	0.00126914	0.217242	1	0
IGHV3-13	28449	broad.mit.edu	37	14	106586240	106586240	+	RNA	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:106586240A>T	ENST00000390602.2	-	0	324																											TCGGCCCTTCACGGAGCCTGG	0.517000													34	68					0	0	0.750413	0	0
KIF4B	285643	broad.mit.edu	37	5	154396290	154396290	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:154396290A>G	ENST00000435029.4	+	1	3031	c.2871A>G	c.(2869-2871)caA>caG	p.Q957Q		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	957	Interaction with PRC1 (By similarity).			Q -> P (in Ref. 1; AF241316).	axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAAAGGAACAACAGCTGGTGA	0.468000													5	41					0	0	0.217242	0	0
CACNG7	59284	broad.mit.edu	37	19	54418655	54418655	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:54418655G>T	ENST00000391767.1	+	4	532	c.320G>T	c.(319-321)aGc>aTc	p.S107I	CACNG7_ENST00000468076.1_3'UTR|CACNG7_ENST00000391766.1_Missense_Mutation_p.S107I|CACNG7_ENST00000222212.2_Missense_Mutation_p.S107I			P62955	CCG7_HUMAN	calcium channel, voltage-dependent, gamma subunit 7	107					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CCCATGGTCAGCCTCTTCCTC	0.597000													11	27					2.61681e-11	3.75159e-11	0.457914	1	0
ACR	49	broad.mit.edu	37	22	51183253	51183253	+	Missense_Mutation	SNP	G	G	T	rs140584689		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:51183253G>T	ENST00000216139.5	+	5	924	c.884G>T	c.(883-885)cGt>cTt	p.R295L	ACR_ENST00000527761.1_3'UTR	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	295					acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		AACGCTTTGCGTATGATTCAA	0.602000													4	13					0.000602214	0.000662436	0.184627	1	0
KCNA5	3741	broad.mit.edu	37	12	5154247	5154247	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:5154247G>A	ENST00000252321.3	+	1	1163	c.934G>A	c.(934-936)Gtg>Atg	p.V312M		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	312						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						TGGCCCTACGGTGGCACCGCT	0.716000													17	50					0	0	0.539581	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409716	59409716	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:59409716C>A	ENST00000301645.3	-	3	492	c.355G>T	c.(355-357)Gga>Tga	p.G119*		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	119					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GTGGTATTTCCATCCATCGGG	0.413000									Neonatal Giant Cell Hepatitis				64	25					1.65906e-26	2.94349e-26	0.870114	1	0
COL4A2	1284	broad.mit.edu	37	13	111155585	111155585	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:111155585G>T	ENST00000360467.5	+	42	4301	c.3995G>T	c.(3994-3996)gGg>gTg	p.G1332V	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1332	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGGGACTCCGGGCCCCAGGGC	0.647000													4	35					0.00909568	0.00960364	0.150653	1	0
NOL4	8715	broad.mit.edu	37	18	31803030	31803030	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:31803030T>A	ENST00000261592.5	-	1	485	c.188A>T	c.(187-189)cAg>cTg	p.Q63L	NOL4_ENST00000269185.4_5'UTR|RP11-379L18.1_ENST00000587528.1_RNA|NOL4_ENST00000589544.1_Missense_Mutation_p.Q63L	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	63						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						CTGGCCCAGCTGGAAGCCCTT	0.587000													17	18					0	0	0.520397	0	0
EVC2	132884	broad.mit.edu	37	4	5564793	5564793	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:5564793C>G	ENST00000310917.2	-	22	4200	c.3469G>C	c.(3469-3471)Gga>Cga	p.G1157R	EVC2_ENST00000344938.1_Intron|EVC2_ENST00000344408.5_Missense_Mutation_p.G1237R	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1237						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CTTCCTTTTCCAGAGAATATC	0.428000													38	80					0	0	0.804634	0	0
RGS22	26166	broad.mit.edu	37	8	100990221	100990221	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:100990221C>T	ENST00000360863.6	-	23	3637	c.3443G>A	c.(3442-3444)aGt>aAt	p.S1148N	RGS22_ENST00000523287.1_Missense_Mutation_p.S967N|RGS22_ENST00000523437.1_Missense_Mutation_p.S1136N	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	1148					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CTCTAAAACACTCATAATATT	0.323000													5	92					0	0	0.184627	0	0
RXFP3	51289	broad.mit.edu	37	5	33937183	33937183	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:33937183G>A	ENST00000330120.3	+	1	693	c.338G>A	c.(337-339)cGc>cAc	p.R113H		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	113						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						CAGGGCTGGCGCAAGTCCTCT	0.592000													21	37					0	0	0.575678	0	0
BDP1	55814	broad.mit.edu	37	5	70805306	70805306	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:70805306A>G	ENST00000358731.4	+	17	2650	c.2387A>G	c.(2386-2388)aAt>aGt	p.N796S	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	796					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		CAAGAGAATAATAAGGCAAAT	0.373000													18	48					0	0	0.575678	0	0
KRT13	3860	broad.mit.edu	37	17	39661352	39661352	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:39661352C>A	ENST00000246635.3	-	1	497	c.451G>T	c.(451-453)Gac>Tac	p.D151Y	KRT13_ENST00000587544.1_Missense_Mutation_p.D151Y|KRT13_ENST00000336861.3_Missense_Mutation_p.D151Y	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	151	Linker 1.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				GGGCTGTAGTCCCGCTCAGGG	0.622000													34	42					3.90053e-15	6.11352e-15	0.760397	1	0
CDH20	28316	broad.mit.edu	37	18	59157924	59157924	+	Silent	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:59157924C>G	ENST00000262717.4	+	2	536	c.138C>G	c.(136-138)ctC>ctG	p.L46L	CDH20_ENST00000536675.2_Silent_p.L46L|CDH20_ENST00000538374.1_Silent_p.L46L			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	46					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				TAGAAGCACTCCTGTCAGACA	0.532000													14	28					0	0	0.457914	0	0
GBA3	57733	broad.mit.edu	37	4	22694602	22694602	+	RNA	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:22694602T>C	ENST00000508166.1	+	0	66				GBA3_ENST00000503442.1_RNA	NM_020973.4	NP_066024.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GCTCTGCTTCTGGCAGCTGAA	0.488000													5	5					0	0	0.184627	0	0
WDYHV1	55093	broad.mit.edu	37	8	124448762	124448762	+	Missense_Mutation	SNP	T	T	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:124448762T>G	ENST00000523984.1	+	4	352	c.124T>G	c.(124-126)Ttg>Gtg	p.L42V	WDYHV1_ENST00000518125.1_Intron|WDYHV1_ENST00000287387.2_Missense_Mutation_p.L102V|WDYHV1_ENST00000523356.1_Missense_Mutation_p.L102V|WDYHV1_ENST00000517609.1_3'UTR			Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	102					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(3)	17						CGATACTGTCTTGCCATTTCC	0.393000													4	73					0	0	0.217242	0	0
GABRA3	2556	broad.mit.edu	37	X	151366210	151366210	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:151366210C>T	ENST00000370314.4	-	8	1064	c.826G>A	c.(826-828)Ggc>Agc	p.G276S	GABRA3_ENST00000535043.1_Missense_Mutation_p.G276S|GABRA3_ENST00000370311.1_Missense_Mutation_p.G276S	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	276					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACAAAGTAGCCAATTTTTCGC	0.423000													12	34					0	0	0.411799	0	0
PPP1CB	5500	broad.mit.edu	37	2	29006809	29006809	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:29006809G>A	ENST00000395366.2	+	5	829	c.557G>A	c.(556-558)cGg>cAg	p.R186Q	SPDYA_ENST00000462832.1_3'UTR|PPP1CB_ENST00000358506.2_Missense_Mutation_p.R186Q|PPP1CB_ENST00000296122.6_Missense_Mutation_p.R186Q	NM_002709.2	NP_002700.1	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta isozyme	186					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			cervix(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	9	Acute lymphoblastic leukemia(172;0.155)					GAGCAGATTCGGAGAATTATG	0.328000													22	66					0	0	0.639603	0	0
MUC3A	4584	broad.mit.edu	37	7	100552963	100552963	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:100552963G>A	ENST00000319509.7	+	2	1608	c.1608G>A	c.(1606-1608)caG>caA	p.Q536Q						mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						GTCAGCTCCAGACCAGATGCC	0.562000													10	74					0	0	0.361761	0	0
PTCHD2	57540	broad.mit.edu	37	1	11577528	11577528	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:11577528C>A	ENST00000294484.6	+	7	1896	c.1758C>A	c.(1756-1758)gcC>gcA	p.A586A	PTCHD2_ENST00000389575.3_Silent_p.A586A	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	586	SSD.				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		AGATCCCAGCCGTCCACGACT	0.617000													41	64					1.5731e-28	2.81576e-28	0.859065	1	0
HK1	3098	broad.mit.edu	37	10	71129011	71129011	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:71129011G>A	ENST00000448642.2	+	11	1104	c.715G>A	c.(715-717)Gta>Ata	p.V239I	HK1_ENST00000494253.1_3'UTR|HK1_ENST00000360289.2_Missense_Mutation_p.V192I|HK1_ENST00000404387.2_Missense_Mutation_p.V208I|HK1_ENST00000359426.6_Missense_Mutation_p.V204I|HK1_ENST00000298649.3_Missense_Mutation_p.V203I			P19367	HXK1_HUMAN	hexokinase 1	204	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						TGCCAACATCGTAGCTGTGGT	0.527000													8	36					0	0	0.307466	0	0
HNRNPCL1	343069	broad.mit.edu	37	1	12907362	12907362	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:12907362C>A	ENST00000317869.6	-	2	1006	c.781G>T	c.(781-783)Gat>Tat	p.D261Y		NM_001013631.1|NM_001136561.2|NM_001146181.1	NP_001013653.1|NP_001130033.2|NP_001139653.1			heterogeneous nuclear ribonucleoprotein C-like 1											NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|stomach(2)	29						TCCCCCTGATCTTCATTAACA	0.502000													7	88					5.18039e-06	6.16956e-06	0.278610	1	0
TNR	7143	broad.mit.edu	37	1	175362963	175362963	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:175362963G>T	ENST00000367674.1	-	6	2017	c.1309C>A	c.(1309-1311)Ccc>Acc	p.P437T	TNR_ENST00000263525.2_Missense_Mutation_p.P437T	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	437	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					AATGAGAAGGGCTCCCACTGC	0.458000													41	88					1.7489e-18	2.91484e-18	0.859065	1	0
USH1C	10083	broad.mit.edu	37	11	17542423	17542423	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:17542423G>T	ENST00000005226.7	-	14	1203	c.1204C>A	c.(1204-1206)Cca>Aca	p.P402T	USH1C_ENST00000318024.4_Missense_Mutation_p.P402T|USH1C_ENST00000527720.1_Missense_Mutation_p.P371T|USH1C_ENST00000527020.1_Missense_Mutation_p.P383T	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	402					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						TTACACTTTGGCTTGCGAAGG	0.522000													127	76					6.55312e-83	1.22365e-82	0.870114	1	0
OR5K3	403277	broad.mit.edu	37	3	98109954	98109954	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:98109954T>C	ENST00000383695.1	+	1	445	c.445T>C	c.(445-447)Tac>Cac	p.Y149H	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005516.1	NP_001005516.1	A6NET4	OR5K3_HUMAN	olfactory receptor, family 5, subfamily K, member 3	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|prostate(1)|skin(1)|urinary_tract(1)	27						TGCAGGAGCCTACCTAGCTGG	0.468000													20	95					0	0	0.592651	0	0
SNHG24	101929369	broad.mit.edu	37	14	101450211	101450211	+	RNA	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:101450211C>A	ENST00000554693.2	+	0	799																											GAAGACCAATCCTGGATCGAT	0.373000													38	103					7.53189e-24	1.30942e-23	0.834066	1	0
ITGAX	3687	broad.mit.edu	37	16	31368412	31368412	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:31368412C>A	ENST00000268296.4	+	4	429	c.308C>A	c.(307-309)tCc>tAc	p.S103Y	ITGAX_ENST00000562918.1_3'UTR|ITGAX_ENST00000562522.1_Missense_Mutation_p.S103Y	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	103					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						ACCAGCCCTTCCCAGCTGCTG	0.677000													7	24					0.0381472	0.0398602	0.278610	1	0
PCDHA9	9752	broad.mit.edu	37	5	140229863	140229863	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:140229863C>T	ENST00000378122.3	+	1	2507	c.1783C>T	c.(1783-1785)Cgc>Tgc	p.R595C	PCDHA7_ENST00000525929.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.R595C|PCDHA6_ENST00000529310.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGGAAGGTGCGCGCAGTGGA	0.687000													5	41					0	0	0.184627	0	0
RAB3IL1	5866	broad.mit.edu	37	11	61666786	61666786	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:61666786C>A	ENST00000394836.2	-	9	1223	c.1066_splice	c.e9+1	p.A356_splice	RAB3IL1_ENST00000301773.5_Splice_Site_p.A330_splice	NM_013401.2	NP_037533.2	Q8TBN0	R3GEF_HUMAN	RAB3A interacting protein (rabin3)-like 1	356							protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(4)|skin(3)|urinary_tract(1)	14						GGGCGCTCACCGTCCTGCCGC	0.657000											OREG0021017	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	12					1.12685e-05	1.32635e-05	0.307466	1	0
CEP120	153241	broad.mit.edu	37	5	122734946	122734946	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:122734946C>A	ENST00000306467.5	-	5	800	c.496G>T	c.(496-498)Gac>Tac	p.D166Y	CEP120_ENST00000395431.2_Missense_Mutation_p.D166Y|CEP120_ENST00000306481.6_Missense_Mutation_p.D140Y|CEP120_ENST00000328236.5_Missense_Mutation_p.D166Y			Q8N960	CE120_HUMAN	centrosomal protein 120kDa	166						centrosome				breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	29						GCCACAATGTCCCTGGGGTCA	0.413000													9	30					0.00621372	0.00660685	0.335167	1	0
PCOLCE2	26577	broad.mit.edu	37	3	142561780	142561780	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:142561780C>A	ENST00000295992.3	-	4	865	c.559G>T	c.(559-561)Gcc>Tcc	p.A187S	PCOLCE2_ENST00000485766.1_Missense_Mutation_p.A187S	NM_013363.3	NP_037495.1	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	187	CUB 2.					extracellular region	collagen binding|heparin binding|peptidase activator activity			NS(1)|endometrium(1)|large_intestine(11)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	32						TTCTTTGGGGCTACAATGTGC	0.532000													29	24					1.74807e-11	2.51805e-11	0.750413	1	0
ZSWIM5	57643	broad.mit.edu	37	1	45484449	45484449	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:45484449G>T	ENST00000359600.5	-	14	3440	c.3235C>A	c.(3235-3237)Cga>Aga	p.R1079R		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	1079							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					GTGCAGCGTCGTAAGATGTCT	0.582000											OREG0013450	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	20					4.74835e-14	7.23616e-14	0.750413	1	0
TMTC1	83857	broad.mit.edu	37	12	29904705	29904705	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:29904705G>T	ENST00000256062.5	-	5	981	c.508C>A	c.(508-510)Cgg>Agg	p.R170R	TMTC1_ENST00000539277.1_Silent_p.R278R|TMTC1_ENST00000381224.2_Silent_p.R170R|TMTC1_ENST00000552618.1_Silent_p.R278R|TMTC1_ENST00000551659.1_Silent_p.R278R	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	278						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TGAGGGAACCGCTGCTGCTTC	0.647000													13	16					7.03913e-09	9.35972e-09	0.411799	1	0
HNRNPR	10236	broad.mit.edu	37	1	23648084	23648084	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:23648084C>G	ENST00000478691.1	-	6	716	c.445G>C	c.(445-447)Gtt>Ctt	p.V149L	HNRNPR_ENST00000427764.2_Missense_Mutation_p.V212L|HNRNPR_ENST00000374612.1_Missense_Mutation_p.V250L|HNRNPR_ENST00000374616.3_Missense_Mutation_p.V250L|HNRNPR_ENST00000302271.6_Missense_Mutation_p.V250L|HNRNPR_ENST00000426846.2_Missense_Mutation_p.V90L|HNRNPR_ENST00000606561.1_Missense_Mutation_p.V111L	NM_001102397.1|NM_001102399.1	NP_001095867.1|NP_001095869.1	O43390	HNRPR_HUMAN	heterogeneous nuclear ribonucleoprotein R	250	Asp/Glu-rich (acidic).					catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;4.15e-05)|all_lung(284;6.64e-05)|Renal(390;0.000219)|Breast(348;0.00394)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;6.83e-27)|Colorectal(126;6.01e-08)|COAD - Colon adenocarcinoma(152;3.32e-06)|GBM - Glioblastoma multiforme(114;6.69e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00357)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0875)|LUSC - Lung squamous cell carcinoma(448;0.19)		ATGGATCCAACAAAAAGTCTG	0.368000													4	87					0	0	0.184627	0	0
PIK3R4	30849	broad.mit.edu	37	3	130452432	130452432	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:130452432T>A	ENST00000356763.3	-	4	1967	c.1410A>T	c.(1408-1410)ttA>ttT	p.L470F		NM_014602.2	NP_055417.1	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	470					fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(6)|large_intestine(16)|lung(28)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	77						CATCTTGGGCTAAGTGGGCTA	0.383000													8	64					0	0	0.307466	0	0
RYR1	6261	broad.mit.edu	37	19	38976684	38976684	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:38976684C>A	ENST00000355481.4	+	34	5520	c.5389C>A	c.(5389-5391)Cgc>Agc	p.R1797S	RYR1_ENST00000360985.3_Missense_Mutation_p.R1797S|RYR1_ENST00000359596.3_Missense_Mutation_p.R1797S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1797	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCCCCGGCCCGCCTCAGCCC	0.716000													32	18					1.61788e-16	2.61716e-16	0.760397	1	0
TRIM14	9830	broad.mit.edu	37	9	100881382	100881382	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:100881382C>A	ENST00000341469.2	-	1	98	c.89G>T	c.(88-90)cGc>cTc	p.R30L	TRIM14_ENST00000375098.3_Missense_Mutation_p.R30L|TRIM14_ENST00000342043.3_Missense_Mutation_p.R30L	NM_014788.2	NP_055603.2	Q14142	TRI14_HUMAN	tripartite motif containing 14	30						cytoplasm|intracellular	zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	9		Acute lymphoblastic leukemia(62;0.0559)				CTCAGCCACGCGGTCGCCATG	0.741000													9	8					1.58986e-06	1.92374e-06	0.361761	1	0
NRIP1	8204	broad.mit.edu	37	21	16339770	16339770	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr21:16339770T>A	ENST00000400202.1	-	3	1456	c.744A>T	c.(742-744)gaA>gaT	p.E248D	NRIP1_ENST00000318948.4_Missense_Mutation_p.E248D|NRIP1_ENST00000400199.1_Missense_Mutation_p.E248D			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	248	Repression domain 1.				androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		TAGCCCTTTTTTCCACCATGC	0.473000													17	89					0	0	0.557998	0	0
ARID1A	8289	broad.mit.edu	37	1	27099370	27099370	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:27099370A>T	ENST00000324856.7	+	14	3978	c.3607A>T	c.(3607-3609)Aat>Tat	p.N1203Y	ARID1A_ENST00000374152.2_Missense_Mutation_p.N820Y|ARID1A_ENST00000457599.2_Missense_Mutation_p.N1203Y	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1203					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCAGAAGCGGAATTCCATGAC	0.473000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								7	45					0	0	0.278610	0	0
MCHR1	2847	broad.mit.edu	37	22	41077234	41077234	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:41077234A>G	ENST00000249016.4	+	2	1267	c.571A>G	c.(571-573)Atg>Gtg	p.M191V	MCHR1_ENST00000498400.1_3'UTR|MCHR1_ENST00000381433.2_Intron	NM_005297.3	NP_005288.3	Q99705	MCHR1_HUMAN	melanin-concentrating hormone receptor 1	191					elevation of cytosolic calcium ion concentration|feeding behavior|generation of precursor metabolites and energy|inhibition of adenylate cyclase activity by G-protein signaling pathway	integral to plasma membrane|nonmotile primary cilium	neuropeptide receptor activity			endometrium(5)|large_intestine(7)|lung(6)|pancreas(1)|urinary_tract(1)	20						CATCACGGCCATGGATGCCAA	0.572000													18	59					0	0	0.557998	0	0
FOXL2	668	broad.mit.edu	37	3	138664549	138664549	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:138664549C>G	ENST00000330315.3	-	1	1433	c.1016G>C	c.(1015-1017)aGt>aCt	p.S339T		NM_023067.3	NP_075555.1	P58012	FOXL2_HUMAN	forkhead box L2	339					convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			large_intestine(1)|lung(1)|ovary(333)|skin(1)	336						GCCCGGCGCACTGGTGggcgc	0.766000			Mis		granulosa-cell tumour of the ovary		"""Blepharophimosis, ptosis and epicanthus inversus Types I, II; Premature ovarian failure type III"""						3	15					0	0	0.115264	0	0
DMD	1756	broad.mit.edu	37	X	32717329	32717329	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:32717329C>T	ENST00000357033.4	-	8	937	c.731G>A	c.(730-732)aGc>aAc	p.S244N	DMD_ENST00000288447.4_Missense_Mutation_p.S236N|DMD_ENST00000378677.2_Missense_Mutation_p.S240N	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	244					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GGCTTCAATGCTCACTTGTTG	0.393000													33	36					0	0	0.788014	0	0
PCDH12	51294	broad.mit.edu	37	5	141336067	141336067	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:141336067G>T	ENST00000231484.3	-	1	2560	c.1350C>A	c.(1348-1350)atC>atA	p.I450I		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	450	Cadherin 4.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATGTCACTGATCTGAATGC	0.488000													30	73					1.80694e-10	2.49589e-10	0.740014	1	0
POTEM	641455	broad.mit.edu	37	14	20019956	20019956	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:20019956A>G	ENST00000551509.1	-	1	316	c.265T>C	c.(265-267)Tct>Cct	p.S89P		NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	89										endometrium(4)|kidney(1)|lung(4)	9						TTCATAGCAGAGTCGTCGTGG	0.627000													8	279					0	0	0.435327	0	0
ADH1A	124	broad.mit.edu	37	4	100205673	100205673	+	Nonsense_Mutation	SNP	G	G	T	rs143808002		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:100205673G>T	ENST00000209668.2	-	5	563	c.450C>A	c.(448-450)taC>taA	p.Y150*	RP11-696N14.1_ENST00000500358.2_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide	150					ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CCACCACTGTGTACTGTGAGA	0.517000													15	23					1.05317e-09	1.42543e-09	0.457914	1	0
SLX4	84464	broad.mit.edu	37	16	3642820	3642820	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:3642820T>A	ENST00000294008.3	-	11	2847	c.2207A>T	c.(2206-2208)cAg>cTg	p.Q736L		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	736	BTB.|Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						CAGGACACGCTGGGTCAGAAC	0.567000								Direct reversal of damage					7	17					0	0	0.278610	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104512136	104512136	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:104512136A>C	ENST00000372582.1	+	5	1365	c.609A>C	c.(607-609)gaA>gaC	p.E203D	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E203D	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	203	Ig-like C2-type 2.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TGATCCAAGAAGTTCAAGAAG	0.333000													4	48					0	0	0.184627	0	0
KLHL1	57626	broad.mit.edu	37	13	70681587	70681587	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:70681587G>C	ENST00000377844.4	-	1	1004	c.245C>G	c.(244-246)cCg>cGg	p.P82R	KLHL1_ENST00000545028.1_5'UTR|ATXN8OS_ENST00000414504.2_RNA	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	82	Ser-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		ggaagaggacggggaggacga	0.597000													7	41					0	0	0.278610	0	0
PLCB1	23236	broad.mit.edu	37	20	8862413	8862413	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:8862413C>A	ENST00000338037.6	+	32	3595	c.3568C>A	c.(3568-3570)Cct>Act	p.P1190T	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1190					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						GTCCTCAGACCCTGGAAAAGT	0.522000													36	142					4.32679e-17	7.05582e-17	0.827153	1	0
ERBB4	2066	broad.mit.edu	37	2	212589910	212589910	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:212589910G>A	ENST00000342788.4	-	6	942	c.632C>T	c.(631-633)aCg>aTg	p.T211M	ERBB4_ENST00000484474.1_5'UTR|ERBB4_ENST00000402597.1_Missense_Mutation_p.T211M|ERBB4_ENST00000436443.1_Missense_Mutation_p.T211M	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	211	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TGCACACACCGTCCTTGTCAC	0.512000										TSP Lung(8;0.080)			10	61					0	0	0.387290	0	0
MTMR12	54545	broad.mit.edu	37	5	32233968	32233968	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:32233968C>T	ENST00000382142.3	-	15	1755	c.1585G>A	c.(1585-1587)Gaa>Aaa	p.E529K	MTMR12_ENST00000264934.5_Intron|MTMR12_ENST00000510216.1_5'UTR|MTMR12_ENST00000280285.5_Intron	NM_001040446.1	NP_001035536.1	Q9C0I1	MTMRC_HUMAN	myotubularin related protein 12	529	Interaction with MTM1.|Myotubularin phosphatase.					cytoplasm	phosphatase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GCTTTGGGTTCAAACTGCACC	0.483000													8	71					0	0	0.307466	0	0
EMB	133418	broad.mit.edu	37	5	49707098	49707098	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:49707098C>A	ENST00000303221.5	-	3	531	c.316G>T	c.(316-318)Gat>Tat	p.D106Y	EMB_ENST00000506190.1_5'UTR|EMB_ENST00000514111.1_Missense_Mutation_p.D56Y|EMB_ENST00000508934.1_Intron	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	106	Ig-like V-type 1.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				TGTTCACCATCTTTTTTCCAA	0.363000													23	57					2.21704e-12	3.27948e-12	0.639603	1	0
SLC6A11	6538	broad.mit.edu	37	3	10885978	10885978	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:10885978G>T	ENST00000254488.2	+	5	769	c.703G>T	c.(703-705)Gcc>Tcc	p.A235S		NM_014229.1	NP_055044.1	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 11	235					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(13)|ovary(1)|skin(4)	35				OV - Ovarian serous cystadenocarcinoma(96;0.229)		TCTCTTGGCAGCCTGGACCAT	0.582000													3	36					0.00909568	0.00960364	0.150653	1	0
HSPG2	3339	broad.mit.edu	37	1	22165395	22165395	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:22165395T>A	ENST00000374695.3	-	74	10152	c.10073A>T	c.(10072-10074)gAg>gTg	p.E3358V		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3358	Ig-like C2-type 19.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GCCTGAGTCCTCAGGGGCTGC	0.677000													8	9					0	0	0.278610	0	0
HK1	3098	broad.mit.edu	37	10	71103609	71103609	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:71103609G>T	ENST00000448642.2	+	7	584	c.195G>T	c.(193-195)cgG>cgT	p.R65R	HK1_ENST00000494253.1_3'UTR|HK1_ENST00000360289.2_Silent_p.R18R|HK1_ENST00000404387.2_Silent_p.R34R|HK1_ENST00000359426.6_Silent_p.R30R|HK1_ENST00000298649.3_Silent_p.R29R			P19367	HXK1_HUMAN	hexokinase 1	30	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane|nucleus	ATP binding|glucokinase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(1)|urinary_tract(2)	35						ATGCCATGCGGCTCTCCGATG	0.527000													35	92					5.80444e-35	1.05456e-34	0.870114	1	0
LRRCC1	85444	broad.mit.edu	37	8	86035652	86035652	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:86035652C>G	ENST00000414626.2	+	6	1764	c.875C>G	c.(874-876)tCt>tGt	p.S292C	LRRCC1_ENST00000360375.3_Missense_Mutation_p.S312C			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	312					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						TTTTAGACTTCTAATTCAATA	0.269000													11	83					0	0	0.411799	0	0
CHL1	10752	broad.mit.edu	37	3	423918	423918	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:423918C>A	ENST00000256509.2	+	17	2575	c.1933C>A	c.(1933-1935)Cgg>Agg	p.R645R	CHL1_ENST00000397491.2_Silent_p.R629R|CHL1-AS1_ENST00000417612.1_RNA	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	629	Fibronectin type-III 1.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		CAGGAGTGTTCGGCTGACCTG	0.403000													11	71					9.31168e-06	1.09816e-05	0.435327	1	0
ITK	3702	broad.mit.edu	37	5	156675975	156675975	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:156675975C>A	ENST00000422843.3	+	16	1901	c.1749C>A	c.(1747-1749)gcC>gcA	p.A583A	ITK_ENST00000519749.1_3'UTR	NM_005546.3	NP_005537.3	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	583	Protein kinase.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(25)|ovary(8)|prostate(2)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	70	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCCGGCTGGCCTCCACACACG	0.498000			T	SYK	peripheral T-cell lymphoma								9	36					9.70103e-10	1.31595e-09	0.361761	1	0
INHBC	3626	broad.mit.edu	37	12	57843083	57843083	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:57843083C>A	ENST00000309668.2	+	2	464	c.337C>A	c.(337-339)Cgt>Agt	p.R113S	INHBC_ENST00000550133.1_Missense_Mutation_p.R113S	NM_005538.2	NP_005529.1	P55103	INHBC_HUMAN	inhibin, beta C	113					growth	extracellular region	growth factor activity|hormone activity|transforming growth factor beta receptor binding			breast(2)|endometrium(1)|large_intestine(6)|liver(2)|lung(4)|prostate(1)	16						CAACCAGACTCGTCTTGATTT	0.498000													69	187					1.42382e-21	2.43336e-21	0.870114	1	0
FMR1	2332	broad.mit.edu	37	X	147009854	147009854	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:147009854A>T	ENST00000218200.8	+	4	442	c.213A>T	c.(211-213)gcA>gcT	p.A71A	FMR1_ENST00000334557.6_Silent_p.A71A|FMR1_ENST00000439526.2_Silent_p.A71A|FMR1_ENST00000370477.1_Silent_p.A71A|FMR1_ENST00000370475.4_Silent_p.A71A|FMR1_ENST00000370471.3_Silent_p.A71A|FMR1_ENST00000370470.1_Silent_p.A71A	NM_001185076.1|NM_001185082.1	NP_001172005.1|NP_001172011.1	Q06787	FMR1_HUMAN	fragile X mental retardation 1	71					mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding			NS(1)|breast(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	35	Acute lymphoblastic leukemia(192;6.56e-05)					ATTCCAGAGCAAATGAAAAAG	0.308000									Fragile X syndrome				39	76					0	0	0.834066	0	0
PCBP1	5093	broad.mit.edu	37	2	70314938	70314938	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:70314938C>G	ENST00000303577.5	+	1	354	c.63C>G	c.(61-63)caC>caG	p.H21Q	PCBP1-AS1_ENST00000413436.1_RNA|PCBP1-AS1_ENST00000423402.1_RNA|PCBP1-AS1_ENST00000452431.1_RNA|PCBP1-AS1_ENST00000596028.1_RNA	NM_006196.3	NP_006187.2	Q15365	PCBP1_HUMAN	poly(rC) binding protein 1	21	KH 1.				nuclear mRNA splicing, via spliceosome	cytoplasm|nucleoplasm|ribonucleoprotein complex	protein binding|RNA binding|single-stranded DNA binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|skin(1)	12						TTCTTATGCACGGAAAGGAAG	0.572000													43	97					0	0	0.853193	0	0
FFAR1	2864	broad.mit.edu	37	19	35842828	35842828	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:35842828G>A	ENST00000246553.2	+	1	384	c.374G>A	c.(373-375)gGg>gAg	p.G125E		NM_005303.2	NP_005294.1	O14842	FFAR1_HUMAN	free fatty acid receptor 1	125					energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity|lipid binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;4.58e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.67e-19)|all cancers(14;2.01e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)		Icosapent(DB00159)	TATTCCTGGGGGGTGTGCGCG	0.687000													7	47					0	0	0.335167	0	0
PCDH15	65217	broad.mit.edu	37	10	55698613	55698613	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:55698613A>C	ENST00000373965.2	-	26	3750	c.3356T>G	c.(3355-3357)cTg>cGg	p.L1119R	PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000320301.6_Missense_Mutation_p.L1112R|PCDH15_ENST00000395445.1_Missense_Mutation_p.L1119R|PCDH15_ENST00000361849.3_Missense_Mutation_p.L1112R|PCDH15_ENST00000395438.1_Missense_Mutation_p.L1112R|PCDH15_ENST00000409834.1_Missense_Mutation_p.L723R|PCDH15_ENST00000395430.1_Missense_Mutation_p.L1112R|PCDH15_ENST00000414778.1_Missense_Mutation_p.L1117R|PCDH15_ENST00000395433.1_Missense_Mutation_p.L1090R|PCDH15_ENST00000437009.1_Missense_Mutation_p.L1041R|PCDH15_ENST00000395432.2_Missense_Mutation_p.L1075R|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000395440.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1112	Cadherin 10.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GACCACTTCCAGGGAATCAGC	0.378000										HNSCC(58;0.16)			28	66					0	0	0.717897	0	0
C11orf82	220042	broad.mit.edu	37	11	82643096	82643096	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:82643096G>T	ENST00000533655.1	+	6	928	c.716G>T	c.(715-717)tGg>tTg	p.W239L	C11orf82_ENST00000430323.2_Missense_Mutation_p.W239L|C11orf82_ENST00000528759.1_3'UTR|C11orf82_ENST00000329143.3_5'UTR|C11orf82_ENST00000525361.1_Intron|C11orf82_ENST00000525388.1_3'UTR	NM_145018.3	NP_659455.3	Q8IXT1	NOXIN_HUMAN	chromosome 11 open reading frame 82	239					apoptosis|cell cycle arrest	cytoplasm|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	33						TCAAAATTCTGGCAGCCATCA	0.378000													10	78					7.48243e-07	9.21969e-07	0.335167	1	0
NUP214	8021	broad.mit.edu	37	9	134073958	134073958	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:134073958A>C	ENST00000359428.5	+	29	5221	c.5077A>C	c.(5077-5079)Aca>Cca	p.T1693P	NUP214_ENST00000451030.1_Missense_Mutation_p.T1694P|NUP214_ENST00000411637.2_Missense_Mutation_p.T1683P|NUP214_ENST00000483497.2_Missense_Mutation_p.T519P			P35658	NU214_HUMAN	nucleoporin 214kDa	1693	11 X 3 AA approximate repeats.|11 X 5 AA approximate repeats.|18 X 4 AA approximate repeats.|Pro/Ser/Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding			NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		GACTGGTAGCACAGCCAGCAC	0.607000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								11	39					0	0	0.361761	0	0
ZEB2	9839	broad.mit.edu	37	2	145156129	145156129	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:145156129C>A	ENST00000558170.2	-	8	3809	c.2625G>T	c.(2623-2625)ctG>ctT	p.L875L	ZEB2_ENST00000539609.3_Silent_p.L851L|ZEB2_ENST00000303660.4_Silent_p.L875L|ZEB2_ENST00000409487.3_Silent_p.L875L	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	875						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TTTTGTTGTCCAGATTATTTG	0.393000													48	72					3.05275e-18	5.07393e-18	0.864702	1	0
KCNA5	3741	broad.mit.edu	37	12	5155089	5155089	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:5155089C>T	ENST00000252321.3	+	1	2005	c.1776C>T	c.(1774-1776)agC>agT	p.S592S		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	592						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						AGGCCAAGAGCAACGTGGACT	0.587000													7	27					0	0	0.248553	0	0
KCNJ6	3763	broad.mit.edu	37	21	39086536	39086536	+	Silent	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr21:39086536T>C	ENST00000400482.3	-	3	1513	c.924A>G	c.(922-924)ctA>ctG	p.L308L	KCNJ6_ENST00000288309.6_Silent_p.L308L	NM_002240.3	NP_002231.1	P48051	IRK6_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 6	308					synaptic transmission	Golgi apparatus|voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	22					Halothane(DB01159)	CCATTCCTTCTAGGATGACCA	0.453000													27	68					0	0	0.729181	0	0
ADSSL1	122622	broad.mit.edu	37	14	105208227	105208227	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:105208227G>T	ENST00000332972.5	+	9	1124	c.965G>T	c.(964-966)gGt>gTt	p.G322V	ADSSL1_ENST00000330877.2_Missense_Mutation_p.G279V	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	279					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	ACCGTGGGCGGTGTGTGCACG	0.602000													36	50					1.62957e-23	2.8249e-23	0.840704	1	0
JAKMIP1	152789	broad.mit.edu	37	4	6066717	6066717	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:6066717A>C	ENST00000409021.3	-	9	1770	c.1321T>G	c.(1321-1323)Ttt>Gtt	p.F441V	JAKMIP1_ENST00000410077.2_Missense_Mutation_p.F276V|JAKMIP1_ENST00000409371.3_Missense_Mutation_p.F256V|JAKMIP1_ENST00000409831.1_Missense_Mutation_p.F441V|JAKMIP1_ENST00000457227.2_5'UTR|JAKMIP1_ENST00000282924.5_Missense_Mutation_p.F441V	NM_001099433.1	NP_001092903.1	Q96N16	JKIP1_HUMAN	janus kinase and microtubule interacting protein 1	441	Mediates interaction with TYK2 and GABBR1.				protein transport	cytoplasm|membrane|microtubule|peripheral to membrane of membrane fraction|ribonucleoprotein complex	GABA receptor binding|RNA binding			NS(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AATCCAAAAAATGTCTCCACA	0.493000													4	44					0	0	0.150653	0	0
XIRP2	129446	broad.mit.edu	37	2	168105385	168105385	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:168105385G>T	ENST00000409195.1	+	9	7572	c.7483G>T	c.(7483-7485)Gac>Tac	p.D2495Y	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.D2495Y|XIRP2_ENST00000409273.1_Missense_Mutation_p.D2273Y|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2320					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATTATCTATTGACTCTGCAAA	0.398000													29	49					7.41945e-09	9.84379e-09	0.693898	1	0
DMXL1	1657	broad.mit.edu	37	5	118485175	118485175	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:118485175C>T	ENST00000311085.8	+	18	3733	c.3653C>T	c.(3652-3654)tCt>tTt	p.S1218F	DMXL1_ENST00000539542.1_Missense_Mutation_p.S1218F	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1218								p.S1218Y(1)|p.S1218C(1)		breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTTCCTGTTTCTTTATCGTGG	0.443000													26	110					0	0	0.693898	0	0
KIF15	56992	broad.mit.edu	37	3	44867569	44867569	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:44867569T>C	ENST00000326047.4	+	21	2737	c.2588T>C	c.(2587-2589)cTa>cCa	p.L863P	KIF15_ENST00000425755.1_Missense_Mutation_p.L498P	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	863					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		AAAGCCTGCCTACAGGATTCC	0.294000													30	27					0	0	0.750413	0	0
KIAA1217	56243	broad.mit.edu	37	10	24508697	24508697	+	Silent	SNP	G	G	T	rs141733021		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:24508697G>T	ENST00000376454.3	+	2	243	c.213G>T	c.(211-213)ggG>ggT	p.G71G	KIAA1217_ENST00000458595.1_Silent_p.G71G|KIAA1217_ENST00000376452.3_Silent_p.G71G|KIAA1217_ENST00000376462.1_5'UTR	NM_019590.3	NP_062536.2	Q5T5P2	SKT_HUMAN	KIAA1217	71					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CCCTAGGGGGGCCCCGAAGTT	0.512000													12	34					1.08611e-07	1.38921e-07	0.387290	1	0
DMXL1	1657	broad.mit.edu	37	5	118486002	118486002	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:118486002C>T	ENST00000311085.8	+	18	4560	c.4480C>T	c.(4480-4482)Ctt>Ttt	p.L1494F	DMXL1_ENST00000539542.1_Missense_Mutation_p.L1494F	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1494										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TGGCCACTTACTTCATTCTAG	0.443000													23	91					0	0	0.639603	0	0
MANSC1	54682	broad.mit.edu	37	12	12483103	12483103	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:12483103A>G	ENST00000535902.1	-	4	1717	c.1154T>C	c.(1153-1155)cTt>cCt	p.L385P	MANSC1_ENST00000396349.3_Missense_Mutation_p.L351P|MANSC1_ENST00000545735.1_Missense_Mutation_p.L304P			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	385						integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		CCCGATAAGAAGCCATTTTTC	0.522000													10	66					0	0	0.361761	0	0
DIRAS2	54769	broad.mit.edu	37	9	93376017	93376017	+	Silent	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:93376017T>C	ENST00000375765.3	-	2	481	c.93A>G	c.(91-93)acA>acG	p.T31T		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	31					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						TCTCCCGGAATGTGCCTTTCA	0.567000													27	91					0	0	0.729181	0	0
RYR3	6263	broad.mit.edu	37	15	33941303	33941303	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:33941303G>T	ENST00000389232.4	+	31	4079	c.4009G>T	c.(4009-4011)Gga>Tga	p.G1337*	RYR3_ENST00000415757.3_Nonsense_Mutation_p.G1337*	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1337	4 X approximate repeats.|B30.2/SPRY 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CATCTTTGCTGGACAGGATCC	0.537000													16	53					1.45105e-14	2.25678e-14	0.539581	1	0
HCN3	57657	broad.mit.edu	37	1	155254959	155254959	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:155254959A>G	ENST00000368358.3	+	5	1101	c.1093A>G	c.(1093-1095)Aag>Gag	p.K365E	HCN3_ENST00000496230.1_3'UTR	NM_020897.1	NP_065948.1	Q9P1Z3	HCN3_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 3	365						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			CCTCCAGTACAAGCAGGTGGA	0.602000													23	47					0	0	0.654019	0	0
ANK2	287	broad.mit.edu	37	4	114276175	114276175	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:114276175C>A	ENST00000357077.4	+	38	6454	c.6401C>A	c.(6400-6402)aCt>aAt	p.T2134N	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.T2101N|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000506722.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2101					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAAACCTCCACTGACTTCTCT	0.468000													14	16					4.3838e-07	5.4572e-07	0.435327	1	0
TROAP	10024	broad.mit.edu	37	12	49717643	49717643	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:49717643C>G	ENST00000551245.1	+	3	271	c.160C>G	c.(160-162)Cca>Gca	p.P54A	TROAP_ENST00000380327.5_Missense_Mutation_p.P54A|TROAP_ENST00000257909.3_Missense_Mutation_p.P54A|TROAP_ENST00000550709.1_Missense_Mutation_p.P54A|TROAP_ENST00000549534.1_3'UTR|TROAP_ENST00000549275.1_Intron|TROAP_ENST00000548311.1_Missense_Mutation_p.P54A|RP11-161H23.9_ENST00000553259.1_RNA			Q12815	TROAP_HUMAN	trophinin associated protein	54					cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						GGTGCAGAAACCACCGCTCAA	0.557000													10	111					0	0	0.361761	0	0
TMEM245	23731	broad.mit.edu	37	9	111798654	111798654	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:111798654G>A	ENST00000374586.3	-	16	2262	c.2231C>T	c.(2230-2232)gCa>gTa	p.A744V		NM_032012.3	NP_114401.2	Q9H330	CI005_HUMAN	transmembrane protein 245	744						integral to membrane											AAGGATTGCTGCTAATGCTGA	0.443000													4	20					0	0	0.150653	0	0
GRM1	2911	broad.mit.edu	37	6	146755228	146755228	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:146755228G>T	ENST00000361719.2	+	9	3351	c.2881G>T	c.(2881-2883)Gag>Tag	p.E961*	GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000492807.2_3'UTR|GRM1_ENST00000282753.1_Nonsense_Mutation_p.E961*|GRM1_ENST00000392299.2_3'UTR	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	961					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AGAGGAGGAGGAGGATGCCCA	0.597000													28	93					9.39395e-14	1.4244e-13	0.706142	1	0
CDH10	1008	broad.mit.edu	37	5	24487944	24487944	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:24487944G>T	ENST00000264463.4	-	12	2702	c.2195C>A	c.(2194-2196)tCa>tAa	p.S732*	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	732					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GGTTGCAAGTGAGTCGTAGGG	0.468000										HNSCC(23;0.051)			37	95					2.40579e-17	3.93379e-17	0.819951	1	0
PRKRIP1	79706	broad.mit.edu	37	7	102065499	102065499	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:102065499G>T	ENST00000496391.1	+	10	1806	c.496G>T	c.(496-498)Gcg>Tcg	p.A166S	PRKRIP1_ENST00000397912.3_Missense_Mutation_p.A166S|PRKRIP1_ENST00000482465.1_3'UTR|PRKRIP1_ENST00000462601.1_Missense_Mutation_p.A109S|PRKRIP1_ENST00000354783.4_Missense_Mutation_p.C106F			Q9H875	PKRI1_HUMAN	PRKR interacting protein 1 (IL11 inducible)	166						nucleolus				endometrium(1)|lung(4)|ovary(1)	6						CAGCAGCTCTGCGGAGGCATC	0.562000													10	23					3.07112e-06	3.68656e-06	0.387290	1	0
PTCHD3	374308	broad.mit.edu	37	10	27687884	27687884	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:27687884C>G	ENST00000438700.3	-	4	1760	c.1643G>C	c.(1642-1644)tGc>tCc	p.C548S		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	548					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CCAGCATAGGCAGACTACTTC	0.393000													30	51					0	0	0.740014	0	0
MMP19	4327	broad.mit.edu	37	12	56231055	56231055	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:56231055G>T	ENST00000394182.1	-	4	433	c.434C>A	c.(433-435)gCt>gAt	p.A145D	MMP19_ENST00000322569.4_Missense_Mutation_p.A431D|MMP19_ENST00000409200.3_3'UTR|MMP19_ENST00000548629.1_Missense_Mutation_p.A408D			Q99542	MMP19_HUMAN	matrix metallopeptidase 19	431					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						ACTCATAGCAGCCGAGGGCTG	0.542000													44	90					2.00842e-17	3.29294e-17	0.853193	1	0
ATP13A2	23400	broad.mit.edu	37	1	17331936	17331936	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:17331936C>A	ENST00000452699.1	-	3	410	c.221G>T	c.(220-222)cGg>cTg	p.R74L	ATP13A2_ENST00000326735.8_Missense_Mutation_p.R74L|ATP13A2_ENST00000341676.5_Missense_Mutation_p.R74L	NM_001141973.1|NM_022089.2	NP_001135445.1|NP_071372.1	Q9NQ11	AT132_HUMAN	ATPase type 13A2	74					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(11)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Colorectal(325;0.000147)|Breast(348;0.00104)|Renal(390;0.00145)|Lung NSC(340;0.00566)|all_lung(284;0.00797)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00462)|COAD - Colon adenocarcinoma(227;1.11e-05)|BRCA - Breast invasive adenocarcinoma(304;1.99e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.182)		GAGCCGCAGCCGCACCCCCCA	0.602000													11	10					1.08611e-07	1.38921e-07	0.387290	1	0
KRT38	8687	broad.mit.edu	37	17	39596963	39596963	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:39596963G>T	ENST00000246646.3	-	1	210	c.211C>A	c.(211-213)Cct>Act	p.P71T		NM_006771.3	NP_006762.3	O76015	KRT38_HUMAN	keratin 38	71	Head.					intermediate filament	structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	29		Breast(137;0.000496)				TGGCAGGTAGGCGGCAGACAG	0.612000													20	50					3.62473e-10	4.97271e-10	0.608945	1	0
KCNA5	3741	broad.mit.edu	37	12	5154798	5154798	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:5154798C>G	ENST00000252321.3	+	1	1714	c.1485C>G	c.(1483-1485)atC>atG	p.I495M		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	495						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						GGGGCAAGATCGTGGGCTCGC	0.602000													29	82					0	0	0.717897	0	0
E2F8	79733	broad.mit.edu	37	11	19259527	19259527	+	Silent	SNP	C	C	G	rs140453196	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:19259527C>G	ENST00000527884.1	-	3	400	c.168G>C	c.(166-168)ccG>ccC	p.P56P	RP11-428C19.4_ENST00000527978.1_RNA|E2F8_ENST00000250024.4_Silent_p.P56P	NM_001256371.1|NM_001256372.1	NP_001243300.1|NP_001243301.1	A0AVK6	E2F8_HUMAN	E2F transcription factor 8	56					cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCGGTGTCCACGGCTCTCCCT	0.512000													13	93					0	0	0.435327	0	0
RSG1	79363	broad.mit.edu	37	1	16560187	16560187	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:16560187C>T	ENST00000375599.3	-	2	604	c.185G>A	c.(184-186)gGg>gAg	p.G62E		NM_030907.3	NP_112169.2	Q9BU20	RSG1_HUMAN	REM2 and RAB-like small GTPase 1	62	Small GTPase-like.				cellular protein localization|cilium assembly|exocytosis|protein transport|regulation of exocytosis|regulation of vesicle fusion|small GTPase mediated signal transduction	cilium|microtubule basal body	GTP binding			large_intestine(2)|lung(2)|pancreas(1)|prostate(1)	6						ACCACTCTTCCCGGACACAAA	0.627000													10	81					0	0	0.361761	0	0
SDK2	54549	broad.mit.edu	37	17	71398169	71398169	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:71398169C>A	ENST00000392650.3	-	19	2596	c.2596G>T	c.(2596-2598)Gag>Tag	p.E866*	SDK2_ENST00000388726.3_Nonsense_Mutation_p.E866*	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	866	Fibronectin type-III 3.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GTGAAGTACTCGGTGAACTTC	0.627000													5	22					1.23904e-05	1.44714e-05	0.184627	1	0
TMEM104	54868	broad.mit.edu	37	17	72781696	72781696	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:72781696G>T	ENST00000335464.5	+	3	283	c.121G>T	c.(121-123)Ggg>Tgg	p.G41W	TMEM104_ENST00000582773.1_Missense_Mutation_p.G41W|TMEM104_ENST00000417024.2_Intron|TMEM104_ENST00000582330.1_Missense_Mutation_p.G41W	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	41						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					CGCCACTGCCGGGTGGCTTGT	0.617000													18	48					8.00594e-06	9.47866e-06	0.557998	1	0
SMCHD1	23347	broad.mit.edu	37	18	2763760	2763760	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr18:2763760C>T	ENST00000320876.6	+	37	5030	c.4692C>T	c.(4690-4692)ccC>ccT	p.P1564P	SMCHD1_ENST00000261598.8_Silent_p.P1564P|RP11-703M24.5_ENST00000583546.1_RNA	NM_015295.2	NP_056110.2	A6NHR9	SMHD1_HUMAN	structural maintenance of chromosomes flexible hinge domain containing 1	1564					chromosome organization		ATP binding			NS(3)|breast(3)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(16)|lung(15)|pancreas(1)	45						TTGAATTCCCCTTCGTGAATG	0.343000													6	35					0	0	0.217242	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846263	47846263	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:47846263G>A	ENST00000339488.4	-	3	2350	c.2317C>T	c.(2317-2319)Ctt>Ttt	p.L773F		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	773						integral to membrane	hedgehog receptor activity										ACAAATAGAAGGGGGACTAAC	0.433000													17	13					0	0	0.500413	0	0
NR2E1	7101	broad.mit.edu	37	6	108501583	108501583	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:108501583G>T	ENST00000368986.4	+	6	1407	c.699G>T	c.(697-699)tgG>tgT	p.W233C	NR2E1_ENST00000368983.3_Missense_Mutation_p.W270C	NM_003269.3	NP_003260.1	Q9Y466	NR2E1_HUMAN	nuclear receptor subfamily 2, group E, member 1	233	Ligand-binding (By similarity).				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(16)|prostate(1)|skin(3)	30		all_cancers(87;8.13e-05)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00866)|Colorectal(196;0.0637)		BRCA - Breast invasive adenocarcinoma(108;0.013)|Epithelial(106;0.0521)|all cancers(137;0.068)|OV - Ovarian serous cystadenocarcinoma(136;0.0689)		TAGCACAATGGGCCATTCCGG	0.338000													13	30					2.62699e-14	4.04409e-14	0.479597	1	0
CLCA4	22802	broad.mit.edu	37	1	87036772	87036772	+	Missense_Mutation	SNP	C	C	A	rs112479973		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:87036772C>A	ENST00000370563.3	+	8	1237	c.1195C>A	c.(1195-1197)Cta>Ata	p.L399I	CLCA4_ENST00000263723.5_Missense_Mutation_p.L112I	NM_012128.3	NP_036260.2	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	399	VWFA.					apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(21)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		GATTGGAGAGCTACATTCCCA	0.413000													17	141					8.34094e-07	1.02151e-06	0.575678	1	0
TAB2	23118	broad.mit.edu	37	6	149730712	149730712	+	Splice_Site	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:149730712G>T	ENST00000367456.1	+	8	2516		c.e8-1		TAB2_ENST00000538427.1_Splice_Site|TAB2_ENST00000286332.5_Splice_Site|TAB2_ENST00000536230.1_Splice_Site			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2						activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding			breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						CTTTCTTACAGATCAAAGGTC	0.368000													23	100					0.000229342	0.000257424	0.608945	1	0
KCTD8	386617	broad.mit.edu	37	4	44177175	44177175	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:44177175A>G	ENST00000360029.3	-	2	1337	c.1054T>C	c.(1054-1056)Tgt>Cgt	p.C352R		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	352						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						AGCTCATTACAGGAAGTCCCA	0.463000										HNSCC(17;0.042)			24	29					0	0	0.639603	0	0
MGAT3	4248	broad.mit.edu	37	22	39883636	39883636	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:39883636G>T	ENST00000341184.6	+	2	499	c.284G>T	c.(283-285)cGg>cTg	p.R95L		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	95					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity			endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					GAGCTCCACCGGGTGGACTTG	0.692000													11	21					3.07112e-06	3.68656e-06	0.387290	1	0
MARCH4	57574	broad.mit.edu	37	2	217124231	217124231	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:217124231G>T	ENST00000273067.4	-	4	2803	c.1037C>A	c.(1036-1038)tCc>tAc	p.S346Y		NM_020814.2	NP_065865.1	Q9P2E8	MARH4_HUMAN	membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase	346						Golgi membrane|Golgi stack|integral to membrane|trans-Golgi network	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(1)	20		Renal(323;0.0854)		Epithelial(149;2.19e-05)|all cancers(144;0.00121)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(261;0.0125)		CTCTTCCGAGGAGGGGATATT	0.617000													6	27					0.248553	0.252306	0.248553	1	0
AMER3	205147	broad.mit.edu	37	2	131520682	131520682	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:131520682G>T	ENST00000423981.1	+	2	1147	c.1037G>T	c.(1036-1038)gGg>gTg	p.G346V	AMER3_ENST00000321420.4_Missense_Mutation_p.G346V	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GACACAGCTGGGCTCGCTGAG	0.677000													17	20					6.94344e-10	9.46122e-10	0.539581	1	0
PNPLA5	150379	broad.mit.edu	37	22	44280198	44280198	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:44280198G>T	ENST00000216177.4	-	7	1109	c.977C>A	c.(976-978)cCc>cAc	p.P326H	PNPLA5_ENST00000597664.1_Missense_Mutation_p.P326H|PNPLA5_ENST00000593866.1_Missense_Mutation_p.P212H|PNPLA5_ENST00000381198.2_Missense_Mutation_p.P212H	NM_138814.3	NP_620169.1	Q7Z6Z6	PLPL5_HUMAN	patatin-like phospholipase domain containing 5	326					lipid catabolic process		hydrolase activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)	16		all_neural(38;0.0966)|Ovarian(80;0.105)|Glioma(61;0.222)				CCACCGGCTGGGATCCCTCGT	0.622000											OREG0026622	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	36					2.5808e-16	4.16369e-16	0.539581	1	0
PLCB1	23236	broad.mit.edu	37	20	8862414	8862414	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:8862414C>A	ENST00000338037.6	+	32	3596	c.3569C>A	c.(3568-3570)cCt>cAt	p.P1190H	PLCB1_ENST00000378641.3_3'UTR	NM_015192.2	NP_056007.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	1190					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TCCTCAGACCCTGGAAAAGTG	0.522000													36	144					3.61848e-18	5.99775e-18	0.834066	1	0
ADSSL1	122622	broad.mit.edu	37	14	105208226	105208226	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:105208226G>A	ENST00000332972.5	+	9	1123	c.964G>A	c.(964-966)Ggt>Agt	p.G322S	ADSSL1_ENST00000330877.2_Missense_Mutation_p.G279S	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	279					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	CACCGTGGGCGGTGTGTGCAC	0.602000													35	49					0	0	0.834066	0	0
ALKBH3	221120	broad.mit.edu	37	11	43908159	43908159	+	Splice_Site	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:43908159A>G	ENST00000378840.4	+	5	624	c.218_splice	c.e5-1	p.E73_splice	ALKBH3_ENST00000302708.4_Silent_p.R74R|ALKBH3_ENST00000532410.1_3'UTR			Q96Q83	ALKB3_HUMAN	alkB, alkylation repair homolog 3 (E. coli)	73					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation	mitochondrion|nucleoplasm	damaged DNA binding|DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			endometrium(2)|kidney(1)|lung(4)|prostate(1)	8					Vitamin C(DB00126)	TCTTTAGCAGAGAGGGTGTGT	0.413000								Direct reversal of damage					6	44					0	0	0.248553	0	0
ABHD2	11057	broad.mit.edu	37	15	89738465	89738465	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:89738465A>T	ENST00000352732.5	+	11	1609	c.1089A>T	c.(1087-1089)cgA>cgT	p.R363R	ABHD2_ENST00000355100.3_Silent_p.R363R|ABHD2_ENST00000565973.1_Silent_p.R363R	NM_152924.4	NP_690888.1	P08910	ABHD2_HUMAN	abhydrolase domain containing 2	363						integral to membrane	carboxylesterase activity			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|soft_tissue(1)	23	Lung NSC(78;0.0472)|all_lung(78;0.089)					CAGAGAAACGAGAGAACGTCA	0.567000													8	39					0	0	0.278610	0	0
FAM65C	140876	broad.mit.edu	37	20	49225886	49225886	+	Nonsense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:49225886C>T	ENST00000327979.2	-	8	983	c.572G>A	c.(571-573)tGg>tAg	p.W191*	FAM65C_ENST00000535356.1_Nonsense_Mutation_p.W195*|FAM65C_ENST00000045083.2_Nonsense_Mutation_p.W191*			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	191										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTCGATGAGCCACATGTCCTG	0.652000													4	17					0	0	0.184627	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728960	15728960	+	RNA	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:15728960T>A	ENST00000441682.2	+	0	407							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						CCTCAGGTACTCCTGCAGAGC	0.552000													40	36					0	0	0.859065	0	0
TAPBPL	55080	broad.mit.edu	37	12	6562638	6562638	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:6562638C>A	ENST00000266556.7	+	3	486	c.321C>A	c.(319-321)gcC>gcA	p.A107A	TAPBPL_ENST00000545700.1_3'UTR|TAPBPL_ENST00000544021.1_Silent_p.A30A	NM_018009.4	NP_060479.3	Q9BX59	TPSNR_HUMAN	TAP binding protein-like	107					antigen processing and presentation of endogenous peptide antigen via MHC class I	endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane				endometrium(2)|large_intestine(1)|skin(2)|upper_aerodigestive_tract(1)	6						TTCCCCAGGCCGAGGCCTTGC	0.572000													27	37					1.17739e-12	1.75449e-12	0.693898	1	0
OR5F1	338674	broad.mit.edu	37	11	55761409	55761409	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:55761409C>A	ENST00000278409.1	-	1	692	c.693G>T	c.(691-693)ggG>ggT	p.G231G		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					GCCTCCCCTCCCCCGAATGCA	0.478000													3	27					0.115264	0.119001	0.115264	1	0
LOC645752	645752	broad.mit.edu	37	15	78208916	78208916	+	RNA	SNP	C	C	G	rs56290535	by1000genomes	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:78208916C>G	ENST00000565869.1	+	0	53																											TCCAGATGTTCTCCTCCATCT	0.627000													4	51					0	0	0.150653	0	0
RHO	6010	broad.mit.edu	37	3	129252498	129252498	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:129252498G>A	ENST00000296271.3	+	5	1078	c.984G>A	c.(982-984)ctG>ctA	p.L328L		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	328					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	AGAACCCACTGGGTGACGATG	0.617000													7	108					0	0	0.278610	0	0
LIFR	3977	broad.mit.edu	37	5	38482707	38482707	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:38482707T>A	ENST00000263409.4	-	19	2816	c.2654A>T	c.(2653-2655)cAa>cTa	p.Q885L	LIFR_ENST00000453190.2_Missense_Mutation_p.Q885L	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	885					positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					GACACTCTTTTGAAACTGTAA	0.259000			T	PLAG1	salivary adenoma								26	76					0	0	0.769981	0	0
RSPO1	284654	broad.mit.edu	37	1	38079564	38079564	+	Splice_Site	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:38079564G>A	ENST00000356545.2	-	7	1224	c.436_splice	c.e7-1	p.A146_splice	RSPO1_ENST00000401068.1_Splice_Site_p.A146_splice|RSPO1_ENST00000401071.2_Intron|RSPO1_ENST00000401070.1_Intron|RSPO1_ENST00000373059.1_Splice_Site_p.A119_splice|RSPO1_ENST00000401069.1_Splice_Site_p.A146_splice	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1	146					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding	p.A146E(1)|p.A146V(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TTCACATTGCGCTGGCAGGAA	0.612000													22	23					0	0	0.639603	0	0
SPAG5	10615	broad.mit.edu	37	17	26919183	26919183	+	Missense_Mutation	SNP	C	C	A	rs142483214	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:26919183C>A	ENST00000321765.5	-	3	1411	c.1079G>T	c.(1078-1080)cGc>cTc	p.R360L		NM_006461.3	NP_006452.3	Q96R06	SPAG5_HUMAN	sperm associated antigen 5	360					cell division|mitosis|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytoplasm|spindle pole	protein binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	43	Lung NSC(42;0.00431)					TAAGCTTTGGCGGAGATTTTC	0.512000													45	57					5.2432e-18	8.66704e-18	0.870114	1	0
ANO8	57719	broad.mit.edu	37	19	17434337	17434337	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:17434337C>T	ENST00000159087.4	-	18	3846	c.3688G>A	c.(3688-3690)Ggc>Agc	p.G1230S		NM_020959.2	NP_066010.1	Q9HCE9	ANO8_HUMAN	anoctamin 8	1230						chloride channel complex	chloride channel activity			autonomic_ganglia(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(3)	27						TAATGCCAGCCGCTGGGCCAG	0.662000													3	32					0	0	0.115264	0	0
OR5F1	338674	broad.mit.edu	37	11	55761408	55761408	+	Nonsense_Mutation	SNP	C	C	A	rs138514211		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:55761408C>A	ENST00000278409.1	-	1	693	c.694G>T	c.(694-696)Gag>Tag	p.E232*		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					TGCCTCCCCTCCCCCGAATGC	0.483000													3	27					0.115264	0.119001	0.115264	1	0
SYNE2	23224	broad.mit.edu	37	14	64545201	64545201	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:64545201A>C	ENST00000357395.3	+	55	11270	c.126A>C	c.(124-126)ttA>ttC	p.L42F	SYNE2_ENST00000394768.2_Missense_Mutation_p.L42F|SYNE2_ENST00000554584.1_Missense_Mutation_p.L3713F|SYNE2_ENST00000358025.3_Missense_Mutation_p.L3680F|SYNE2_ENST00000555002.1_Missense_Mutation_p.L314F|SYNE2_ENST00000344113.4_Missense_Mutation_p.L3680F			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	3680	Actin-binding.|CH 1.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		ATGAAGTCTTAAAAAGCTCAC	0.353000													4	34					0	0	0.150653	0	0
TOR1AIP2	163590	broad.mit.edu	37	1	179815614	179815614	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:179815614C>A	ENST00000367612.3	-	6	1392	c.1005G>T	c.(1003-1005)agG>agT	p.R335S		NM_001199260.1|NM_145034.4	NP_001186189.1|NP_659471.1	Q8NFQ8	TOIP2_HUMAN	torsin A interacting protein 2	335						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(10)|ovary(1)|skin(2)	18						CCTGCCAGGTCCTTCCAGCCC	0.547000													9	72					0.000442599	0.000489529	0.335167	1	0
SP4	6671	broad.mit.edu	37	7	21521557	21521557	+	Silent	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:21521557A>T	ENST00000222584.3	+	5	2141	c.1923A>T	c.(1921-1923)ccA>ccT	p.P641P		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	641					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						GTAATGAACCAGGAAAAAAGA	0.338000													16	96					0	0	0.520397	0	0
VN1R2	317701	broad.mit.edu	37	19	53762039	53762039	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:53762039G>C	ENST00000341702.3	+	1	495	c.411G>C	c.(409-411)ttG>ttC	p.L137F		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	137					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		CTGACTCCTTGGTTATCCTAT	0.368000													28	51					0	0	0.740014	0	0
ANO7	50636	broad.mit.edu	37	2	242149780	242149780	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:242149780G>A	ENST00000274979.8	+	14	1695	c.1592G>A	c.(1591-1593)aGg>aAg	p.R531K	ANO7_ENST00000402430.3_Missense_Mutation_p.R530K	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	531						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						GTGGTGTCCAGGTCGGGCAAC	0.677000													4	31					0	0	0.184627	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46942261	46942261	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:46942261C>A	ENST00000429979.1	-	5	1346	c.742G>T	c.(742-744)Gat>Tat	p.D248Y	KIAA0226L_ENST00000378787.3_Missense_Mutation_p.D248Y|KIAA0226L_ENST00000322896.6_Missense_Mutation_p.D91Y|KIAA0226L_ENST00000389908.3_Missense_Mutation_p.D248Y|KIAA0226L_ENST00000378797.2_Missense_Mutation_p.D248Y|KIAA0226L_ENST00000409879.2_Missense_Mutation_p.D91Y|KIAA0226L_ENST00000378781.3_Missense_Mutation_p.D248Y|KIAA0226L_ENST00000534925.1_Missense_Mutation_p.D113Y|KIAA0226L_ENST00000378784.4_Missense_Mutation_p.D181Y	NM_025113.2	NP_079389.2	Q9H714	CM018_HUMAN	KIAA0226-like	248										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						TCAGGCTGATCACTCCCAAGT	0.408000													62	100					5.73332e-34	1.03852e-33	0.870114	1	0
UBE3B	89910	broad.mit.edu	37	12	109972414	109972414	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:109972414G>C	ENST00000342494.3	+	28	3629	c.3034G>C	c.(3034-3036)Ggc>Cgc	p.G1012R	UBE3B_ENST00000434735.2_Missense_Mutation_p.G1012R	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1012	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						GGACACTCTGGGCAGCGTCCT	0.652000													8	26					0	0	0.335167	0	0
OR2A5	393046	broad.mit.edu	37	7	143748122	143748122	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:143748122C>A	ENST00000408906.2	+	1	662	c.628C>A	c.(628-630)Ccg>Acg	p.P210T		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					CCTGGTGGGGCCGCTCTGCCT	0.592000													75	80					3.83446e-41	7.0512e-41	0.870114	1	0
FREM2	341640	broad.mit.edu	37	13	39266287	39266287	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:39266287C>A	ENST00000280481.7	+	1	5022	c.4806C>A	c.(4804-4806)atC>atA	p.I1602I		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1602					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		AAAACTTAATCAGCTACAAAC	0.418000													16	54					1.3612e-06	1.65367e-06	0.479597	1	0
MATN2	4147	broad.mit.edu	37	8	99015971	99015971	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:99015971C>A	ENST00000254898.5	+	8	1518	c.1287C>A	c.(1285-1287)caC>caA	p.H429Q	MATN2_ENST00000520016.1_Missense_Mutation_p.H429Q|MATN2_ENST00000522025.2_Missense_Mutation_p.H145Q|MATN2_ENST00000524308.1_Missense_Mutation_p.H388Q|MATN2_ENST00000521689.1_Missense_Mutation_p.H429Q	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	429	EGF-like 5.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GCCGCTGCCACCGTGGCTACA	0.602000													80	12					2.40982e-25	4.23819e-25	0.870114	1	0
LAMB4	22798	broad.mit.edu	37	7	107752255	107752255	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:107752255C>A	ENST00000388781.3	-	4	412		c.e4+1		LAMB4_ENST00000205386.4_Splice_Site|LAMB4_ENST00000414450.2_Splice_Site|LAMB4_ENST00000388780.3_Splice_Site	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4						cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TTAAATCATACCATTTTCAGA	0.338000													12	66					5.50884e-06	6.53499e-06	0.411799	1	0
CELSR2	1952	broad.mit.edu	37	1	109793580	109793580	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:109793580G>A	ENST00000271332.3	+	1	940	c.879G>A	c.(877-879)gaG>gaA	p.E293E		NM_001408.2	NP_001399.1	Q9HCU4	CELR2_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 2	293	Cadherin 2.				dendrite morphogenesis|homophilic cell adhesion|neural plate anterior/posterior regionalization|neuropeptide signaling pathway|regulation of cell-cell adhesion|regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(27)|ovary(5)|prostate(1)|skin(3)|urinary_tract(2)	82		all_epithelial(167;0.000114)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0296)|Lung(183;0.067)|COAD - Colon adenocarcinoma(174;0.114)|Epithelial(280;0.193)|all cancers(265;0.219)		AGCAGCAGGAGTACAAGGAGA	0.582000													4	66					0	0	0.217242	0	0
HIST1H2AE	3012	broad.mit.edu	37	6	26217423	26217423	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:26217423A>T	ENST00000303910.2	+	1	259	c.221A>T	c.(220-222)aAt>aTt	p.N74I		NM_021052.2	NP_066390.1	P04908	H2A1B_HUMAN	histone cluster 1, H2ae	74					nucleosome assembly	nucleosome|nucleus	DNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)	10		all_hematologic(11;0.196)				GCTCGCGACAATAAGAAGACC	0.617000													10	100					0	0	0.387290	0	0
MMP1	4312	broad.mit.edu	37	11	102668050	102668050	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:102668050T>A	ENST00000315274.6	-	2	354	c.287A>T	c.(286-288)gAt>gTt	p.D96V	WTAPP1_ENST00000525739.2_RNA	NM_001145938.1|NM_002421.3	NP_001139410.1|NP_002412.1	P03956	MMP1_HUMAN	matrix metallopeptidase 1 (interstitial collagenase)	96					blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		CTGAGCCACATCAGGCACTCC	0.512000													9	47					0	0	0.307466	0	0
TAOK2	9344	broad.mit.edu	37	16	29994574	29994574	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:29994574C>T	ENST00000308893.4	+	12	2224	c.1181C>T	c.(1180-1182)cCt>cTt	p.P394L	TAOK2_ENST00000543033.1_Missense_Mutation_p.P394L|TAOK2_ENST00000279394.3_Missense_Mutation_p.P394L|TAOK2_ENST00000416441.2_Missense_Mutation_p.P221L	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	394	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						gaagaAGGCCCTGAAGCCCGG	0.617000													8	21					0	0	0.307466	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643084	1643084	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:1643084G>T	ENST00000399682.1	-	1	284	c.240C>A	c.(238-240)ggC>ggA	p.G80G		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	80	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AAGAGCCATAGCCCCCCTTGG	0.662000													39	46					4.64027e-19	7.79822e-19	0.870114	1	0
TBC1D15	64786	broad.mit.edu	37	12	72316795	72316795	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:72316795G>T	ENST00000550746.1	+	18	1951	c.1887G>T	c.(1885-1887)ggG>ggT	p.G629G	TBC1D15_ENST00000393309.3_Silent_p.G383G|TBC1D15_ENST00000319106.8_Silent_p.G620G|TBC1D15_ENST00000485960.2_Silent_p.G612G	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	629							protein binding|Rab GTPase activator activity	p.G629G(1)		NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGATCCTTGGGCTTCAAGGCA	0.398000													16	47					3.32936e-07	4.18766e-07	0.539581	1	0
ADAMTS20	80070	broad.mit.edu	37	12	43777627	43777627	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:43777627T>A	ENST00000389420.3	-	30	4605	c.4606A>T	c.(4606-4608)Atg>Ttg	p.M1536L		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1536	TSP type-1 13.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCTCTTTCCATCCCCTTGTGC	0.438000													12	95					0	0	0.411799	0	0
FRYL	285527	broad.mit.edu	37	4	48636308	48636308	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:48636308C>A	ENST00000358350.4	-	4	724	c.120_splice	c.e4+1	p.L40_splice	FRYL_ENST00000507711.1_Splice_Site_p.L40_splice|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000537810.1_Splice_Site_p.L40_splice|FRYL_ENST00000503238.1_Splice_Site_p.L40_splice	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	40					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CTGTACTCACCAAGGGTTCGG	0.338000													37	39					2.05212e-20	3.47768e-20	0.812448	1	0
GCK	2645	broad.mit.edu	37	7	44197682	44197682	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:44197682G>T	ENST00000395796.3	-	2	316	c.32C>A	c.(31-33)cCc>cAc	p.P11H	GCK_ENST00000403799.3_Intron|GCK_ENST00000345378.2_Intron|GCK_ENST00000437084.1_Intron|GCK_ENST00000476008.1_Intron	NM_033508.1	NP_277043.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	0			A -> T.		cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						CTGggagttgggttgtgggag	0.542000													24	18					9.57634e-11	1.33188e-10	0.654019	1	0
IFI16	3428	broad.mit.edu	37	1	158984735	158984735	+	Splice_Site	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:158984735G>C	ENST00000295809.7	+	2	520	c.265_splice	c.e2+1	p.V89_splice	IFI16_ENST00000448393.2_Splice_Site_p.V89_splice|IFI16_ENST00000340979.6_Splice_Site_p.V89_splice|IFI16_ENST00000368131.4_Splice_Site_p.V89_splice|IFI16_ENST00000359709.3_Splice_Site_p.V89_splice|IFI16_ENST00000430894.2_Splice_Site_p.V93_splice|IFI16_ENST00000368132.3_Splice_Site_p.V89_splice			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	89	Lys-rich.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					AAAGTTAAAAGGTAATTGGGA	0.443000													4	60					0	0	0.150653	0	0
PDE4B	5142	broad.mit.edu	37	1	66458793	66458793	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:66458793G>T	ENST00000423207.2	+	1	689	c.204G>T	c.(202-204)cgG>cgT	p.R68R	PDE4B_ENST00000329654.4_Intron|PDE4B_ENST00000371049.3_Intron	NM_001037340.1	NP_001032417.1	Q07343	PDE4B_HUMAN	phosphodiesterase 4B, cAMP-specific	179					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	37					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	AAAGCATTCGGCAGCGTCGTC	0.448000													32	31					2.68265e-12	3.95854e-12	0.769981	1	0
FSTL4	23105	broad.mit.edu	37	5	132561401	132561401	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:132561401T>C	ENST00000265342.7	-	9	1375	c.1126A>G	c.(1126-1128)Aaa>Gaa	p.K376E	FSTL4_ENST00000507112.1_5'UTR	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	376	Ig-like 2.					extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACGCCGTTTTTCAGCCAAGTG	0.517000													15	75					0	0	0.457914	0	0
SEC14L1	6397	broad.mit.edu	37	17	75208130	75208130	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:75208130G>A	ENST00000413679.2	+	15	2013	c.1710G>A	c.(1708-1710)tcG>tcA	p.S570S	SEC14L1_ENST00000392476.2_Silent_p.S570S|SEC14L1_ENST00000436233.4_Silent_p.S570S|SEC14L1_ENST00000443798.4_Silent_p.S570S|SEC14L1_ENST00000431431.2_Silent_p.S536S|SEC14L1_ENST00000591437.1_Silent_p.S536S|SEC14L1_ENST00000585618.1_Silent_p.S570S|SEC14L1_ENST00000430767.4_Silent_p.S570S	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	570	GOLD.				transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						CCAAGAGGTCGCCACAACCAC	0.527000													28	282					0	0	0.750413	0	0
SLITRK6	84189	broad.mit.edu	37	13	86369560	86369560	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr13:86369560G>T	ENST00000400286.2	-	2	1682	c.1084C>A	c.(1084-1086)Ccg>Acg	p.P362T		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	362						integral to membrane		p.P362T(1)		breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GGATTTTGCGGAGGAGGTCTC	0.413000													11	70					9.70103e-10	1.31595e-09	0.361761	1	0
TEX2	55852	broad.mit.edu	37	17	62290241	62290241	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:62290241G>T	ENST00000258991.3	-	2	1421	c.1337C>A	c.(1336-1338)cCa>cAa	p.P446Q	TEX2_ENST00000584379.1_Missense_Mutation_p.P446Q|TEX2_ENST00000583097.1_Missense_Mutation_p.P446Q			Q8IWB9	TEX2_HUMAN	testis expressed 2	446				P -> S (in Ref. 2; CAH10519).	signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		GAGCACCTCTGGCTTGAGAGG	0.507000													66	101					3.00467e-41	5.54215e-41	0.870114	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3673738	3673738	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:3673738G>T	ENST00000344754.4	-	14	3548	c.3549C>A	c.(3547-3549)agC>agA	p.S1183R	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.S1183R	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1183	Ig-like C2-type 12.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCCCGCCATGGCTCTCCAGGA	0.692000													7	21					0.00307968	0.00330942	0.278610	1	0
PTN	5764	broad.mit.edu	37	7	136938254	136938254	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:136938254G>T	ENST00000348225.2	-	3	673	c.246C>A	c.(244-246)acC>acA	p.T82T	PTN_ENST00000393083.2_Silent_p.T82T	NM_002825.5	NP_002816.1	P21246	PTN_HUMAN	pleiotrophin	82					nervous system development|positive regulation of cell division|positive regulation of cell proliferation|transmembrane receptor protein tyrosine phosphatase signaling pathway	endoplasmic reticulum|extracellular space	growth factor activity|heparin binding|protein phosphatase inhibitor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	23						TACATCTCTGGGTCTTCATGG	0.512000													23	40					5.45024e-15	8.5204e-15	0.654019	1	0
ISM1	140862	broad.mit.edu	37	20	13279910	13279910	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:13279910C>G	ENST00000262487.3	+	6	1205	c.1199C>G	c.(1198-1200)gCg>gGg	p.A400G	TASP1_ENST00000539805.1_Intron	NM_080826.1	NP_543016.1	B1AKI9	ISM1_HUMAN	isthmin 1, angiogenesis inhibitor	400	AMOP.					extracellular region				NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(8)|lung(5)|urinary_tract(1)	17						GGCAAGGGGGCGGGCACGCCC	0.622000													4	7					0	0	0.150653	0	0
RHPN2	85415	broad.mit.edu	37	19	33471061	33471061	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:33471061G>C	ENST00000254260.3	-	15	1937	c.1902C>G	c.(1900-1902)atC>atG	p.I634M	RHPN2_ENST00000588683.1_5'UTR|RHPN2_ENST00000400226.4_Missense_Mutation_p.I483M	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	634					signal transduction	perinuclear region of cytoplasm	protein binding	p.I634I(1)		NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					GCTTCTTGGAGATTTTCTTGG	0.493000													19	87					0	0	0.592651	0	0
CNOT1	23019	broad.mit.edu	37	16	58568148	58568148	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:58568148T>A	ENST00000317147.5	-	40	6130	c.5798A>T	c.(5797-5799)tAt>tTt	p.Y1933F	CNOT1_ENST00000245138.4_Missense_Mutation_p.Y784F|CNOT1_ENST00000569240.1_Missense_Mutation_p.Y1928F	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1933					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CAGGTTGTGATAGCACTTGGC	0.502000													17	28					0	0	0.500413	0	0
OR2T5	401993	broad.mit.edu	37	1	248651971	248651971	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:248651971C>T	ENST00000366473.2	+	1	87	c.82C>T	c.(82-84)Cca>Tca	p.P28S		NM_001004697.1	NP_001004697.1	Q6IEZ7	OR2T5_HUMAN	olfactory receptor, family 2, subfamily T, member 5	28					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|ovary(2)|pancreas(1)|skin(2)	9	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCCAAACATCCAGCTCTACT	0.502000													9	128					0	0	0.435327	0	0
TG	7038	broad.mit.edu	37	8	133899667	133899667	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:133899667G>T	ENST00000220616.4	+	9	2090	c.2050G>T	c.(2050-2052)Gtc>Ttc	p.V684F	TG_ENST00000377869.1_Missense_Mutation_p.V684F	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	684	Thyroglobulin type-1 6.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACCTTGTTTGTCCCTGCTTG	0.557000													5	89					0.014758	0.015528	0.184627	1	0
FLG2	388698	broad.mit.edu	37	1	152326750	152326750	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:152326750G>T	ENST00000388718.5	-	3	3584	c.3512C>A	c.(3511-3513)tCt>tAt	p.S1171Y	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1171	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ACCTGAGCCAGACTCATGTTG	0.493000													32	109					1.39806e-14	2.17996e-14	0.729181	1	0
AMER3	205147	broad.mit.edu	37	2	131520173	131520173	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:131520173G>T	ENST00000423981.1	+	2	638	c.528G>T	c.(526-528)tcG>tcT	p.S176S	AMER3_ENST00000321420.4_Silent_p.S176S	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		ACTTGGCCTCGCTGGCGGCCG	0.642000													18	59					5.03518e-11	7.1009e-11	0.557998	1	0
KLHL2	11275	broad.mit.edu	37	4	166141117	166141117	+	Missense_Mutation	SNP	G	G	T	rs143711077		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:166141117G>T	ENST00000226725.6	+	2	317	c.58G>T	c.(58-60)Gat>Tat	p.D20Y	KLHL2_ENST00000538127.1_5'UTR|KLHL2_ENST00000514860.1_Missense_Mutation_p.D24Y	NM_007246.3	NP_009177.3	O95198	KLHL2_HUMAN	kelch-like family member 2	20					intracellular protein transport	actin cytoskeleton|cytoplasm	actin binding|transporter activity			endometrium(3)|large_intestine(5)|lung(4)|prostate(1)|urinary_tract(1)	14	all_hematologic(180;0.221)			GBM - Glioblastoma multiforme(119;2.94e-27)|COAD - Colon adenocarcinoma(41;1.4e-05)|Kidney(143;4.95e-05)|KIRC - Kidney renal clear cell carcinoma(143;0.000927)		GAAGCCTCTCGATTCAAAAGA	0.348000													9	30					1.76689e-08	2.32385e-08	0.335167	1	0
LRFN5	145581	broad.mit.edu	37	14	42356305	42356305	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:42356305A>G	ENST00000554171.1	+	5	2909	c.477A>G	c.(475-477)ctA>ctG	p.L159L	LRFN5_ENST00000298119.4_Silent_p.L159L|LRFN5_ENST00000554120.1_Silent_p.L159L			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	159						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		ATAATAATCTAGAAACCATTC	0.408000										HNSCC(30;0.082)			11	65					0	0	0.387290	0	0
ULK1	8408	broad.mit.edu	37	12	132400695	132400695	+	Silent	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:132400695C>T	ENST00000321867.4	+	19	2220	c.1869C>T	c.(1867-1869)tcC>tcT	p.S623S		NM_003565.2	NP_003556.1	O75385	ULK1_HUMAN	unc-51 like autophagy activating kinase 1	623					autophagy|protein localization|regulation of autophagy	autophagic vacuole|cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	ATP binding|protein complex binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	29	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.07e-08)|Epithelial(86;2.56e-07)|all cancers(50;3.01e-07)		TCCTGGGCTCCCCCACCAAGG	0.662000													6	17					0	0	0.307466	0	0
ASTL	431705	broad.mit.edu	37	2	96795647	96795647	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:96795647G>T	ENST00000342380.2	-	8	789	c.790C>A	c.(790-792)Cga>Aga	p.R264R		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	264					proteolysis		metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						AGGTTCCATCGCTGGCCGATG	0.667000													7	44					0.00198382	0.00213941	0.248553	1	0
AXDND1	126859	broad.mit.edu	37	1	179399720	179399720	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:179399720T>C	ENST00000367618.3	+	14	1853	c.1466T>C	c.(1465-1467)aTc>aCc	p.I489T	AXDND1_ENST00000457238.2_Missense_Mutation_p.I489T|AXDND1_ENST00000461179.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	489										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GATGGGCTTATCAAATGGCAG	0.363000													12	79					0	0	0.520397	0	0
LIPC	3990	broad.mit.edu	37	15	58834784	58834784	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:58834784G>T	ENST00000414170.3	+	5	795	c.508G>T	c.(508-510)Ggt>Tgt	p.G170C	LIPC_ENST00000299022.5_Missense_Mutation_p.G170C|LIPC_ENST00000356113.6_Missense_Mutation_p.G170C|LIPC_ENST00000433326.2_Missense_Mutation_p.G109C			P11150	LIPC_HUMAN	lipase, hepatic	170					cholesterol homeostasis|chylomicron remnant clearance|fatty acid biosynthetic process|high-density lipoprotein particle remodeling|intermediate-density lipoprotein particle remodeling|low-density lipoprotein particle remodeling|phosphatidylcholine catabolic process|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	high-density lipoprotein particle	apolipoprotein binding|heparin binding|low-density lipoprotein particle binding|phospholipase activity|triglyceride lipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Colorectal(260;0.215)		GBM - Glioblastoma multiforme(80;0.00213)|all cancers(107;0.00548)		GTACAGCCTGGGTGCACACGT	0.532000													19	55					1.00905e-13	1.52238e-13	0.575678	1	0
MYH11	4629	broad.mit.edu	37	16	15818569	15818569	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr16:15818569G>T	ENST00000338282.6	-	30	4157	c.4051C>A	c.(4051-4053)Cag>Aag	p.Q1351K	MYH11_ENST00000452625.2_Missense_Mutation_p.Q1358K|MYH11_ENST00000300036.5_Missense_Mutation_p.Q1351K|NDE1_ENST00000571896.1_3'UTR|NDE1_ENST00000396354.1_3'UTR|NDE1_ENST00000342673.5_3'UTR|MYH11_ENST00000576790.1_Missense_Mutation_p.Q1351K|NDE1_ENST00000396355.1_3'UTR|MYH11_ENST00000396324.3_Missense_Mutation_p.Q1358K	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1351					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						TCGTCCAGCTGGTCTTGCAGG	0.587000			T	CBFB	AML								18	91					1.01871e-10	1.41358e-10	0.575678	1	0
TTN	7273	broad.mit.edu	37	2	179631224	179631224	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:179631224T>C	ENST00000589042.1	-	41	9811	c.9587A>G	c.(9586-9588)tAt>tGt	p.Y3196C	TTN_ENST00000591111.1_Missense_Mutation_p.Y3196C|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000360870.5_Missense_Mutation_p.Y3196C|TTN_ENST00000359218.5_Missense_Mutation_p.Y3150C|TTN_ENST00000460472.2_Missense_Mutation_p.Y3150C|TTN_ENST00000342992.6_Missense_Mutation_p.Y3196C|TTN_ENST00000342175.6_Missense_Mutation_p.Y3150C	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	2929							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCACTACATATTTGTGTCG	0.428000													8	87					0	0	0.278610	0	0
HAVCR1	26762	broad.mit.edu	37	5	156464287	156464287	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:156464287A>C	ENST00000339252.3	-	6	1455	c.923T>G	c.(922-924)cTt>cGt	p.L308R	HAVCR1_ENST00000425854.1_Missense_Mutation_p.L308R|HAVCR1_ENST00000522693.1_Missense_Mutation_p.L308R|HAVCR1_ENST00000517644.1_5'UTR|HAVCR1_ENST00000544197.1_Missense_Mutation_p.L308R|HAVCR1_ENST00000523175.1_Missense_Mutation_p.L308R	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	303					interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CAAAAGAGCAAGAAGCACCAA	0.423000													10	75					0	0	0.387290	0	0
POU1F1	5449	broad.mit.edu	37	3	87322560	87322560	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:87322560G>T	ENST00000350375.2	-	2	275	c.151C>A	c.(151-153)Ctt>Att	p.L51I	POU1F1_ENST00000344265.3_Missense_Mutation_p.L77I|POU1F1_ENST00000560656.1_Missense_Mutation_p.L51I	NM_000306.2	NP_000297.1	P28069	PIT1_HUMAN	POU class 1 homeobox 1	51					negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(2)	18	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		GAATAATGAAGTCCTGTTGCT	0.393000													4	44					0.00909568	0.00960364	0.150653	1	0
OLFM1	10439	broad.mit.edu	37	9	137990334	137990334	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:137990334C>G	ENST00000252854.4	+	4	792	c.605C>G	c.(604-606)gCa>gGa	p.A202G	OLFM1_ENST00000371793.3_Missense_Mutation_p.A220G|OLFM1_ENST00000371796.3_Missense_Mutation_p.A193G	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	220					nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		AGGCTCCGTGCATGCATGCAA	0.552000													6	30					0	0	0.217242	0	0
BRPF3	27154	broad.mit.edu	37	6	36168953	36168953	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:36168953G>A	ENST00000357641.6	+	2	1107	c.854G>A	c.(853-855)gGg>gAg	p.G285E	BRPF3_ENST00000443324.2_Missense_Mutation_p.G285E|BRPF3_ENST00000534694.1_Missense_Mutation_p.G285E|BRPF3_ENST00000534400.1_Missense_Mutation_p.G285E|BRPF3_ENST00000543502.1_Missense_Mutation_p.G285E|BRPF3_ENST00000339717.7_Missense_Mutation_p.G285E	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	285					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						ACCAGTGATGGGCACTGGGCC	0.572000													31	51					0	0	0.740014	0	0
BOC	91653	broad.mit.edu	37	3	113002307	113002307	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:113002307C>A	ENST00000495514.1	+	16	3185	c.2481C>A	c.(2479-2481)gcC>gcA	p.A827A	BOC_ENST00000355385.3_Silent_p.A827A|BOC_ENST00000273395.4_Silent_p.A828A			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	827					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			CAACTCTGGCCCCACCACAGC	0.582000													46	76					1.00953e-15	1.61578e-15	0.864702	1	0
PPFIBP1	8496	broad.mit.edu	37	12	27840339	27840339	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:27840339G>T	ENST00000318304.8	+	24	2570	c.2287G>T	c.(2287-2289)Gtt>Ttt	p.V763F	PPFIBP1_ENST00000542629.1_Missense_Mutation_p.V732F|PPFIBP1_ENST00000228425.6_Missense_Mutation_p.V757F|PPFIBP1_ENST00000537927.1_Missense_Mutation_p.V610F	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	763	SAM 2.				cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					GTCTCTGAAGGTTGTAAGTGT	0.468000													10	84					1.76689e-08	2.32385e-08	0.335167	1	0
ZBTB22	9278	broad.mit.edu	37	6	33283774	33283774	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:33283774G>A	ENST00000431845.2	-	2	1071	c.920C>T	c.(919-921)cCa>cTa	p.P307L	ZBTB22_ENST00000418724.1_Missense_Mutation_p.P307L	NM_005453.4	NP_005444.4	O15209	ZBT22_HUMAN	zinc finger and BTB domain containing 22	307					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(3)	21						TGTTGGCGCTGGGCAATTACC	0.562000													23	78					0	0	0.608945	0	0
HDAC9	9734	broad.mit.edu	37	7	18687590	18687590	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:18687590A>G	ENST00000406451.3	+	10	1359	c.1209A>G	c.(1207-1209)gaA>gaG	p.E403E	HDAC9_ENST00000456174.2_Silent_p.E375E|HDAC9_ENST00000417496.2_Silent_p.E401E|HDAC9_ENST00000432645.2_Silent_p.E403E|HDAC9_ENST00000401921.1_Silent_p.E362E|HDAC9_ENST00000406072.1_Silent_p.E390E|HDAC9_ENST00000428307.2_Silent_p.E359E|HDAC9_ENST00000524023.1_Silent_p.E326E|HDAC9_ENST00000405010.3_Silent_p.E403E|HDAC9_ENST00000441542.2_Silent_p.E406E	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	403					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TATTGAAAGAACAAATGCGAC	0.443000													3	20					0	0	0.115264	0	0
IL12A	3592	broad.mit.edu	37	3	159711625	159711625	+	Silent	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:159711625G>T	ENST00000305579.2	+	6	907	c.600G>T	c.(598-600)ctG>ctT	p.L200L	IL12A_ENST00000480787.1_Silent_p.L162L|CTD-2049J23.2_ENST00000497452.1_RNA|IL12A_ENST00000466512.1_Silent_p.L186L	NM_000882.3	NP_000873.2	P29459	IL12A_HUMAN	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	166					cell cycle arrest|cell migration|defense response to Gram-positive bacterium|immune response|negative regulation of interleukin-17 production|negative regulation of smooth muscle cell proliferation|positive regulation of cell adhesion|positive regulation of interferon-gamma production|positive regulation of natural killer cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|positive regulation of NK T cell activation|positive regulation of smooth muscle cell apoptosis|positive regulation of T cell mediated cytotoxicity|positive regulation of tyrosine phosphorylation of Stat4 protein|response to lipopolysaccharide|response to UV-B|response to virus	interleukin-12 complex	cytokine activity|growth factor activity|interleukin-12 receptor binding|interleukin-27 binding|protein heterodimerization activity			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	9			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTGATGAGCTGATGCAGGTAA	0.418000													27	155					2.09667e-21	3.57319e-21	0.788014	1	0
KAT6A	7994	broad.mit.edu	37	8	41794835	41794835	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:41794835C>A	ENST00000396930.3	-	17	3834	c.3291G>T	c.(3289-3291)caG>caT	p.Q1097H	KAT6A_ENST00000265713.2_Missense_Mutation_p.Q1097H|KAT6A_ENST00000406337.1_Missense_Mutation_p.Q1097H	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	1097					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										TAGAAGAGGACTGACACCTGA	0.408000													41	28					2.45108e-15	3.8517e-15	0.840704	1	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261651	39261651	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:39261651C>G	ENST00000391415.1	+	1	68	c.11C>G	c.(10-12)tCc>tGc	p.S4C		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	4						keratin filament				central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						ATGGTCAGCTCCTGTTGTGGC	0.592000													19	23					0	0	0.575678	0	0
COL13A1	1305	broad.mit.edu	37	10	71707071	71707071	+	Silent	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:71707071T>C	ENST00000356340.3	+	36	2534	c.1998T>C	c.(1996-1998)caT>caC	p.H666H	COL13A1_ENST00000398968.3_Silent_p.H647H|COL13A1_ENST00000522165.1_Silent_p.H635H|COL13A1_ENST00000357811.3_Silent_p.H632H|COL13A1_ENST00000398969.3_Silent_p.H594H|COL13A1_ENST00000398974.3_Silent_p.H654H|COL13A1_ENST00000398964.3_Silent_p.H637H|COL13A1_ENST00000398973.3_Silent_p.H640H|COL13A1_ENST00000398971.3_Silent_p.H651H|COL13A1_ENST00000520267.1_Silent_p.H594H|COL13A1_ENST00000520133.1_Silent_p.H588H|COL13A1_ENST00000398978.3_Silent_p.H666H|COL13A1_ENST00000398972.3_Silent_p.H652H|COL13A1_ENST00000398966.3_Silent_p.H644H|COL13A1_ENST00000517713.1_Silent_p.H617H|COL13A1_ENST00000354547.3_Silent_p.H644H			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	666	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	AGGGTTTACATGGACCACCCG	0.512000													9	25					0	0	0.435327	0	0
TGS1	96764	broad.mit.edu	37	8	56717541	56717541	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:56717541G>A	ENST00000260129.5	+	10	2566	c.2089G>A	c.(2089-2091)Gca>Aca	p.A697T		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	697	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TGTAGTAGACGCATTCTGTGG	0.428000													93	19					0	0	0.870114	0	0
MAP2	4133	broad.mit.edu	37	2	210560055	210560055	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:210560055G>T	ENST00000360351.4	+	7	3667	c.3161G>T	c.(3160-3162)gGa>gTa	p.G1054V	MAP2_ENST00000361559.4_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.G1050V|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1054					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGTGACTTTGGACAGATGGCT	0.468000													11	64					6.40141e-05	7.33495e-05	0.387290	1	0
OR56A3	390083	broad.mit.edu	37	11	5969306	5969306	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:5969306A>T	ENST00000329564.6	+	1	737	c.730A>T	c.(730-732)Aca>Tca	p.T244S		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCCTAAGCACATGTGGCTC	0.522000													22	120					0	0	0.624587	0	0
ZNF585A	199704	broad.mit.edu	37	19	37643422	37643422	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:37643422T>C	ENST00000356958.4	-	5	1637	c.1379A>G	c.(1378-1380)cAc>cGc	p.H460R	ZNF585A_ENST00000392157.2_Missense_Mutation_p.H405R|ZNF585A_ENST00000355533.2_Intron|ZNF585A_ENST00000292841.5_Missense_Mutation_p.H405R|ZNF585A_ENST00000588723.1_Intron			Q6P3V2	Z585A_HUMAN	zinc finger protein 585A	460					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(2)|large_intestine(17)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCTCCTGTGTGAATTCGTTT	0.398000													14	135					0	0	0.479597	0	0
WDR52	55779	broad.mit.edu	37	3	113092327	113092327	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:113092327T>A	ENST00000393845.2	-	18	2441	c.2375A>T	c.(2374-2376)aAa>aTa	p.K792I	WDR52_ENST00000295868.2_Missense_Mutation_p.K792I	NM_001164496.1	NP_001157968.1	Q96MT7	WDR52_HUMAN	WD repeat domain 52	792										breast(2)|central_nervous_system(3)|endometrium(3)|kidney(5)|large_intestine(7)|lung(26)|prostate(1)|urinary_tract(2)	49						AGGTTCATCTTTTTGTTCTTT	0.368000													8	31					0	0	0.278610	0	0
PAM	5066	broad.mit.edu	37	5	102309956	102309956	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:102309956G>C	ENST00000438793.3	+	14	1769	c.1299G>C	c.(1297-1299)aaG>aaC	p.K433N	PAM_ENST00000348126.2_Intron|PAM_ENST00000455264.2_Missense_Mutation_p.K433N|PAM_ENST00000304400.7_Missense_Mutation_p.K433N|PAM_ENST00000274392.9_Missense_Mutation_p.K336N|PAM_ENST00000346918.2_Missense_Mutation_p.K433N|PAM_ENST00000379787.4_5'UTR	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	433	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	TCCAAAAAAAGGATCTTGGTC	0.413000													8	59					0	0	0.278610	0	0
RYR1	6261	broad.mit.edu	37	19	38960151	38960151	+	Nonsense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:38960151G>T	ENST00000355481.4	+	27	3894	c.3763G>T	c.(3763-3765)Gag>Tag	p.E1255*	RYR1_ENST00000360985.3_Nonsense_Mutation_p.E1255*|RYR1_ENST00000359596.3_Nonsense_Mutation_p.E1255*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1255	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCTCACTATGAGGTAAGGAC	0.532000													26	34					1.64293e-13	2.47257e-13	0.654019	1	0
GIMAP1	170575	broad.mit.edu	37	7	150417416	150417416	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:150417416G>A	ENST00000307194.5	+	3	464	c.324G>A	c.(322-324)tcG>tcA	p.S108S		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ACCTGCTCTCGGCCCCCGGAC	0.637000													8	36					0	0	0.307466	0	0
FAT4	79633	broad.mit.edu	37	4	126242649	126242649	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr4:126242649A>C	ENST00000394329.3	+	1	5096	c.5083A>C	c.(5083-5085)Att>Ctt	p.I1695L		NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1695	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GACCGCAGCCATTCTGGACCG	0.433000													8	82					0	0	0.307466	0	0
PDZRN3	23024	broad.mit.edu	37	3	73657834	73657834	+	Splice_Site	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr3:73657834C>A	ENST00000263666.4	-	2	839	c.723_splice	c.e2-1	p.G242_splice	PDZRN3_ENST00000308537.4_Splice_Site_p.G242_splice	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	242							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GGTTTCTTCGCCCTGCAGGTA	0.433000													3	7					0.115264	0.119001	0.115264	1	0
TNXB	7148	broad.mit.edu	37	6	32053672	32053672	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:32053672C>A	ENST00000375244.3	-	7	3204	c.3003G>T	c.(3001-3003)ccG>ccT	p.P1001P	TNXB_ENST00000375247.2_Silent_p.P1001P			P22105	TENX_HUMAN	tenascin XB	1088	Fibronectin type-III 2.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CATGTGCCCCCGGCCCCTCGG	0.667000													11	46					7.93312e-07	9.73537e-07	0.457914	1	0
AGMO	392636	broad.mit.edu	37	7	15430465	15430465	+	Splice_Site	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:15430465C>T	ENST00000342526.3	-	7	911	c.742_splice	c.e7+1	p.G248_splice		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	248					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						TTTTACTTACCAAAAATTTTA	0.264000													7	22					0	0	0.248553	0	0
CGB1	114335	broad.mit.edu	37	19	49539443	49539443	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:49539443C>T	ENST00000301407.7	-	2	231	c.127G>A	c.(127-129)Gtg>Atg	p.V43M	CTB-60B18.6_ENST00000591656.1_Intron|CGB1_ENST00000391869.3_Missense_Mutation_p.V43M	NM_033377.1	NP_203695.2	A6NKQ9	CGB1_HUMAN	chorionic gonadotropin, beta polypeptide 1	75						extracellular region	hormone activity	p.V43L(1)		liver(1)|lung(1)	2		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		GTGATGCACACGGGGCAGCCC	0.682000													19	80					0	0	0.624587	0	0
USH2A	7399	broad.mit.edu	37	1	215847758	215847758	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:215847758G>T	ENST00000366943.2	-	63	13881	c.13495C>A	c.(13495-13497)Ctc>Atc	p.L4499I	USH2A_ENST00000307340.3_Missense_Mutation_p.L4499I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4499	Fibronectin type-III 30.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CCTGGGGTGAGAGTAAAATCA	0.478000										HNSCC(13;0.011)			18	151					9.16793e-09	1.21105e-08	0.520397	1	0
EIF4E1B	253314	broad.mit.edu	37	5	176070229	176070229	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:176070229C>A	ENST00000318682.6	+	4	746	c.162C>A	c.(160-162)ccC>ccA	p.P54P	EIF4E1B_ENST00000504597.1_Silent_p.P54P	NM_001099408.1	NP_001092878.1	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E family member 1B	54					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			breast(1)|large_intestine(1)|lung(2)|pancreas(1)	5	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGGGGGCCCCATGGAAGTCA	0.617000													9	38					2.17888e-05	2.53992e-05	0.335167	1	0
KRT4	3851	broad.mit.edu	37	12	53207760	53207760	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:53207760C>A	ENST00000551956.1	-	1	575	c.83G>T	c.(82-84)gGt>gTt	p.G28V	KRT4_ENST00000293774.4_Missense_Mutation_p.G102V|KRT4_ENST00000458244.2_Missense_Mutation_p.G28V			B4DRS2	B4DRS2_HUMAN	keratin 4	28						keratin filament	structural molecule activity			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|prostate(2)|skin(2)	29						GCTGAAGGCACCTCTCTTGCC	0.607000													12	113					0.000978159	0.00107208	0.387290	1	0
AGO4	192670	broad.mit.edu	37	1	36299598	36299598	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:36299598A>T	ENST00000373210.3	+	12	1632	c.1387A>T	c.(1387-1389)Act>Tct	p.T463S		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		CAGGAGTTTCACTGACCAGCT	0.413000													18	37					0	0	0.539581	0	0
TRRAP	8295	broad.mit.edu	37	7	98491471	98491471	+	Silent	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:98491471A>G	ENST00000359863.4	+	6	626	c.417A>G	c.(415-417)ctA>ctG	p.L139L	TRRAP_ENST00000355540.3_Silent_p.L139L|TRRAP_ENST00000446306.3_Silent_p.L139L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	139					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TTATTGAGCTACACAAACAGT	0.294000													10	71					0	0	0.335167	0	0
EGFLAM	133584	broad.mit.edu	37	5	38370470	38370470	+	Silent	SNP	C	C	G	rs150656160	byFrequency	TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:38370470C>G	ENST00000322350.5	+	6	964	c.618C>G	c.(616-618)ctC>ctG	p.L206L	EGFLAM_ENST00000354891.3_Silent_p.L206L	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	206	Fibronectin type-III 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TCAAGGGCCTCGATCCAGATA	0.522000													25	32					0	0	0.654019	0	0
UBBP4	23666	broad.mit.edu	37	17	21731176	21731176	+	Missense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:21731176C>A	ENST00000584755.1	+	2	875	c.478C>A	c.(478-480)Ctg>Atg	p.L160M	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L160M|UBBP4_ENST00000584398.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						CGTGAAGACCCTGACCGGCAA	0.537000													25	69					1.04121e-07	1.34314e-07	0.693898	1	0
PCDH11X	27328	broad.mit.edu	37	X	91131884	91131884	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:91131884C>A	ENST00000373094.1	+	2	1490	c.645C>A	c.(643-645)taC>taA	p.Y215*	PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000395337.2_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000361724.1_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000504220.1_Nonsense_Mutation_p.Y215*|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.Y215*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	215	Cadherin 2.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						AGGATACCTACGTGATGAAAG	0.408000													25	69					4.75821e-42	8.80343e-42	0.870114	1	0
OR51F1	256892	broad.mit.edu	37	11	4790663	4790663	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:4790663A>C	ENST00000380383.1	-	1	505	c.506T>G	c.(505-507)cTt>cGt	p.L169R	OR51F1_ENST00000343430.3_Missense_Mutation_p.L162R|MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	162						integral to membrane	olfactory receptor activity	p.L162R(1)		kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		AAGGAGCAAAAGTAGTGGCAA	0.398000													9	73					0	0	0.335167	0	0
COL11A1	1301	broad.mit.edu	37	1	103345402	103345402	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:103345402G>T	ENST00000358392.2	-	66	5464	c.5147C>A	c.(5146-5148)gCc>gAc	p.A1716D	COL11A1_ENST00000370096.3_Missense_Mutation_p.A1704D|COL11A1_ENST00000353414.4_Missense_Mutation_p.A1665D|COL11A1_ENST00000512756.1_Missense_Mutation_p.A1588D	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1704	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCGAGCAGAGGCAGTCAGAAG	0.413000													8	59					2.74318e-10	3.78046e-10	0.335167	1	0
SNX7	51375	broad.mit.edu	37	1	99167426	99167426	+	Missense_Mutation	SNP	A	A	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:99167426A>C	ENST00000370189.5	+	8	1264	c.900A>C	c.(898-900)gaA>gaC	p.E300D	SNX7_ENST00000306121.3_Missense_Mutation_p.E364D|SNX7_ENST00000529992.1_Missense_Mutation_p.E309D			Q9UNH6	SNX7_HUMAN	sorting nexin 7	300					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)	13		all_epithelial(167;7.64e-07)|all_lung(203;0.0006)|Lung NSC(277;0.00137)		Epithelial(280;0.0521)|all cancers(265;0.0687)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.207)|Colorectal(170;0.234)		CCAAAGTTGAAGTTTTGACCT	0.294000													19	124					0	0	0.557998	0	0
FAM47C	442444	broad.mit.edu	37	X	37026658	37026658	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chrX:37026658C>T	ENST00000358047.3	+	1	227	c.175C>T	c.(175-177)Cgc>Tgc	p.R59C		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	59										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						GGACGACTTCCGCTACGGCTG	0.557000													11	37					0	0	0.361761	0	0
CTSV	1515	broad.mit.edu	37	9	99795258	99795258	+	Silent	SNP	G	G	A	rs149018053		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:99795258G>A	ENST00000259470.5	-	8	1227	c.978C>T	c.(976-978)gcC>gcT	p.A326A	CTSV_ENST00000538255.1_Silent_p.A326A	NM_001333.3	NP_001324.2			cathepsin V																		TGGCTGCTGTGGCGATTCCAC	0.473000													16	37					0	0	0.520397	0	0
PHF20L1	51105	broad.mit.edu	37	8	133855062	133855062	+	Missense_Mutation	SNP	A	A	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr8:133855062A>T	ENST00000395386.2	+	19	2989	c.2690A>T	c.(2689-2691)cAc>cTc	p.H897L	AF230666.2_ENST00000429151.1_RNA|PHF20L1_ENST00000220847.7_Missense_Mutation_p.H284L|PHF20L1_ENST00000395390.2_Missense_Mutation_p.H872L	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	897							nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			CAAGAATTCCACATGAGAAGT	0.383000													111	39					0	0	0.870114	0	0
TGM6	343641	broad.mit.edu	37	20	2411240	2411240	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:2411240C>A	ENST00000202625.2	+	11	1888	c.1827C>A	c.(1825-1827)acC>acA	p.T609T	TGM6_ENST00000381423.1_Silent_p.T609T	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	609					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	ACTTCATCACCATCAAGGTGA	0.547000													12	35					3.07112e-06	3.68656e-06	0.387290	1	0
NT5C1A	84618	broad.mit.edu	37	1	40131284	40131284	+	Nonsense_Mutation	SNP	G	G	T	rs140346943		TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:40131284G>T	ENST00000235628.1	-	3	341	c.342C>A	c.(340-342)taC>taA	p.Y114*		NM_032526.1	NP_115915.1	Q9BXI3	5NT1A_HUMAN	5'-nucleotidase, cytosolic IA	114					purine base metabolic process|purine nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			breast(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(2)	15	Lung NSC(20;3.81e-06)|Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			CACTATCAGGGTACAGCTCCC	0.562000													6	23					3.59834e-05	4.15457e-05	0.217242	1	0
PKD1L1	168507	broad.mit.edu	37	7	47944064	47944064	+	Missense_Mutation	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:47944064G>C	ENST00000289672.2	-	12	1892	c.1842C>G	c.(1840-1842)atC>atG	p.I614M		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	614	PKD 2.				cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TGCCGAAGTTGATCCAGCACT	0.572000													8	51					0	0	0.335167	0	0
DIDO1	11083	broad.mit.edu	37	20	61513452	61513452	+	Missense_Mutation	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:61513452G>A	ENST00000266070.4	-	16	4181	c.3856C>T	c.(3856-3858)Cca>Tca	p.P1286S	DIDO1_ENST00000395343.1_Missense_Mutation_p.P1286S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1286	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GCTGTGGCTGGGCTGGGGGCT	0.637000													9	83					0	0	0.387290	0	0
SFI1	9814	broad.mit.edu	37	22	31985511	31985511	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:31985511C>A	ENST00000432498.1	+	14	1792	c.1399C>A	c.(1399-1401)Cga>Aga	p.R467R	SFI1_ENST00000443326.1_Silent_p.R416R|SFI1_ENST00000443011.1_Silent_p.R345R|SFI1_ENST00000540643.1_Silent_p.R443R|SFI1_ENST00000414585.1_Silent_p.R345R|SFI1_ENST00000400288.2_Silent_p.R498R|SFI1_ENST00000400289.1_Silent_p.R416R	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	498					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						CAGACTCTGGCGATGGCGCCA	0.522000													17	50					3.32936e-07	4.18766e-07	0.539581	1	0
OLIG3	167826	broad.mit.edu	37	6	137814988	137814988	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr6:137814988C>T	ENST00000367734.2	-	1	543	c.320G>A	c.(319-321)cGc>cAc	p.R107H		NM_175747.2	NP_786923.1	Q7RTU3	OLIG3_HUMAN	oligodendrocyte transcription factor 3	107	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	11	Breast(32;0.165)|Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00161)|OV - Ovarian serous cystadenocarcinoma(155;0.00447)		CATGACTTCGCGCAGCCCGTC	0.607000													23	67					0	0	0.624587	0	0
SOS1	6654	broad.mit.edu	37	2	39249965	39249965	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:39249965T>C	ENST00000426016.1	-	11	1690	c.1604A>G	c.(1603-1605)aAc>aGc	p.N535S	SOS1_ENST00000402219.2_Missense_Mutation_p.N535S|SOS1_ENST00000395038.2_Missense_Mutation_p.N535S			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	535	PH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				CATCCAATTGTTTTTCTCTTC	0.358000									Noonan syndrome				46	51					0	0	0.870114	0	0
NPC1L1	29881	broad.mit.edu	37	7	44571748	44571748	+	Silent	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:44571748C>A	ENST00000289547.4	-	9	2533	c.2478G>T	c.(2476-2478)ggG>ggT	p.G826G	NPC1L1_ENST00000546276.1_Silent_p.G826G|NPC1L1_ENST00000381160.3_Silent_p.G826G	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	826					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	CAAGCAGGAGCCCCTCTCCCT	0.642000													30	42					2.80507e-11	4.00252e-11	0.760397	1	0
KCNA5	3741	broad.mit.edu	37	12	5154224	5154224	+	Missense_Mutation	SNP	T	T	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:5154224T>A	ENST00000252321.3	+	1	1140	c.911T>A	c.(910-912)aTg>aAg	p.M304K		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	304						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						AGCGGGGTCATGGCCCCGCCC	0.706000													13	38					0	0	0.435327	0	0
PABPN1	8106	broad.mit.edu	37	14	23794470	23794470	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr14:23794470C>G	ENST00000216727.4	+	7	1077	c.896C>G	c.(895-897)gCg>gGg	p.A299G	PABPN1_ENST00000397276.2_3'UTR|PABPN1_ENST00000556821.1_Missense_Mutation_p.A171G|BCL2L2-PABPN1_ENST00000553781.1_Missense_Mutation_p.A326G|BCL2L2-PABPN1_ENST00000557008.1_Missense_Mutation_p.A326G	NM_004643.3	NP_004634.1			poly(A) binding protein, nuclear 1											large_intestine(1)|lung(1)|ovary(2)	4	all_cancers(95;6.69e-06)			GBM - Glioblastoma multiforme(265;0.00643)		CGGGCTAGAGCGACATCATGG	0.423000													61	66					0	0	0.870114	0	0
FAM227B	196951	broad.mit.edu	37	15	49903438	49903438	+	Nonsense_Mutation	SNP	C	C	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr15:49903438C>A	ENST00000299338.6	-	3	382	c.79G>T	c.(79-81)Gaa>Taa	p.E27*	FAM227B_ENST00000561064.1_Nonsense_Mutation_p.E27*|FAM227B_ENST00000558862.1_5'UTR|FAM227B_ENST00000560246.1_Nonsense_Mutation_p.E27*|FAM227B_ENST00000558594.1_Nonsense_Mutation_p.E27*	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		AAGAATTCTTCAATGCTCTTT	0.279000													6	25					0.217242	0.221265	0.217242	1	0
KLK8	11202	broad.mit.edu	37	19	51503889	51503889	+	Silent	SNP	G	G	A			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr19:51503889G>A	ENST00000391806.2	-	3	236	c.156C>T	c.(154-156)ccC>ccT	p.P52P	KLK8_ENST00000593490.1_Intron|CTB-147C22.9_ENST00000594512.1_RNA|KLK9_ENST00000376832.4_Intron|KLK9_ENST00000250366.6_Intron|KLK8_ENST00000600767.1_Intron|KLK8_ENST00000347619.4_Intron|KLK8_ENST00000320838.5_Intron|KLK8_ENST00000291726.7_Intron			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	23	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GGCAGTGCGAGGGCTGGGAAG	0.622000													18	42					0	0	0.520397	0	0
FBN2	2201	broad.mit.edu	37	5	127730897	127730897	+	Missense_Mutation	SNP	C	C	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:127730897C>T	ENST00000508053.1	-	15	2123	c.1149G>A	c.(1147-1149)atG>atA	p.M383I	FBN2_ENST00000508989.1_Missense_Mutation_p.M350I|FBN2_ENST00000262464.4_Missense_Mutation_p.M383I			P35556	FBN2_HUMAN	fibrillin 2	383	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GCATTTTCGTCATTCTCCCCG	0.537000													7	22					0	0	0.307466	0	0
NAB2	4665	broad.mit.edu	37	12	57485446	57485446	+	Missense_Mutation	SNP	T	T	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:57485446T>C	ENST00000300131.3	+	2	1000	c.622T>C	c.(622-624)Ttc>Ctc	p.F208L	NAB2_ENST00000342556.6_Missense_Mutation_p.F208L|NAB2_ENST00000357680.4_Missense_Mutation_p.F208L|NAB2_ENST00000554718.1_3'UTR	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	208					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity	p.F208L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						CTCGCCCCCCTTCTCCCCCCC	0.716000													4	19					0	0	0.307466	0	0
RASGRF2	5924	broad.mit.edu	37	5	80511762	80511762	+	Missense_Mutation	SNP	A	A	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr5:80511762A>G	ENST00000265080.4	+	24	3489	c.3422A>G	c.(3421-3423)gAa>gGa	p.E1141G	CTC-281B15.1_ENST00000511495.1_RNA|CTC-281B15.1_ENST00000503483.2_RNA	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	1141	Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		AATCTTAGAGAAACCCTTAAA	0.264000													6	17					0	0	0.217242	0	0
GCC2	9648	broad.mit.edu	37	2	109088072	109088072	+	Missense_Mutation	SNP	C	C	G			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:109088072C>G	ENST00000309863.6	+	6	3001	c.2287C>G	c.(2287-2289)Ctt>Gtt	p.L763V		NM_181453.3	NP_852118.1	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain containing 2	763					Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			breast(8)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	54						GTATGGTTTTCTTAAAGAAAT	0.338000													13	60					0	0	0.411799	0	0
LANCL2	55915	broad.mit.edu	37	7	55466259	55466259	+	Missense_Mutation	SNP	G	G	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:55466259G>T	ENST00000254770.2	+	3	1044	c.466G>T	c.(466-468)Gct>Tct	p.A156S	LANCL2_ENST00000486376.1_3'UTR	NM_018697.3	NP_061167.1	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2 (bacterial)	156					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	25	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			TGGCCCCCTGGCTGTTGGAGC	0.488000													4	31					1.23904e-05	1.44714e-05	0.184627	1	0
ZNF638	27332	broad.mit.edu	37	2	71591219	71591219	+	Silent	SNP	G	G	C			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:71591219G>C	ENST00000409544.1	+	5	2184	c.1554G>C	c.(1552-1554)ccG>ccC	p.P518P	ZNF638_ENST00000377802.2_Silent_p.P518P|ZNF638_ENST00000355812.3_Silent_p.P518P|ZNF638_ENST00000264447.4_Silent_p.P518P|ZNF638_ENST00000410075.1_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	518	Arg-rich.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TGTATAGGCCGAGAAGTCGAA	0.448000													27	41					0	0	0.681144	0	0
IFI44L	10964	broad.mit.edu	37	1	79102763	79102763	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:79102763delC	ENST00000370751.4	+	6	1102	c.923delC	c.(922-924)acfs	p.T308fs	IFI44L_ENST00000342282.3_Frame_Shift_Del_p.T50fs|IFI44L_ENST00000476521.1_Intron	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	308						cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						ACTTTTATCACCTCTCCATCT	0.373													13	149	---	---	---	---					
PI4KB	5298	broad.mit.edu	37	1	151280136	151280136	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr1:151280136delG	ENST00000368875.2	-	5	1712	c.1132delC	c.(1132-1134)gafs	p.R378fs	PI4KB_ENST00000271657.5_Frame_Shift_Del_p.R378fs|PI4KB_ENST00000368872.1_Frame_Shift_Del_p.R351fs|PI4KB_ENST00000368873.1_Frame_Shift_Del_p.R366fs|PI4KB_ENST00000368874.4_Frame_Shift_Del_p.R351fs|PI4KB_ENST00000529142.1_Frame_Shift_Del_p.R34fs	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	366					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGCCAGACTCGGGCAGGGAGC	0.592													8	60	---	---	---	---					
CERS6	253782	broad.mit.edu	37	2	169574401	169574402	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr2:169574401_169574402insT	ENST00000305747.6	+	8	1345_1346	c.758_759insT	c.(757-759)tgcfs	p.C253fs	CERS6_ENST00000392687.4_Frame_Shift_Ins_p.C253fs	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	253	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										ATGGCAAATTATGCCAAGTTTC	0.351													27	34	---	---	---	---					
IKZF1	10320	broad.mit.edu	37	7	50468265	50468265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:50468265delG	ENST00000331340.3	+	8	1655	c.1500delG	c.(1498-1500)cafs	p.Q500fs	IKZF1_ENST00000349824.4_Frame_Shift_Del_p.Q357fs|IKZF1_ENST00000439701.1_Frame_Shift_Del_p.Q458fs|IKZF1_ENST00000346667.4_Frame_Shift_Del_p.Q270fs|IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000438033.1_Frame_Shift_Del_p.Q413fs|IKZF1_ENST00000359197.5_Frame_Shift_Del_p.Q458fs|IKZF1_ENST00000357364.4_Frame_Shift_Del_p.Q413fs|IKZF1_ENST00000343574.5_Frame_Shift_Del_p.Q413fs	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	500					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				ACCACAGCCAGGACCGGTACG	0.627			"""D,T"""	BCL6	"""ALL, DLBCL"""								7	25	---	---	---	---					
CALN1	83698	broad.mit.edu	37	7	71275333	71275334	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr7:71275333_71275334insT	ENST00000395275.2	-	6	1033_1034	c.645_646insA	c.(643-648)acagttfs	p.V216fs	CALN1_ENST00000329008.5_Frame_Shift_Ins_p.V174fs|CALN1_ENST00000431984.1_Frame_Shift_Ins_p.V174fs|CALN1_ENST00000412588.1_Frame_Shift_Ins_p.V216fs|CALN1_ENST00000395276.2_Frame_Shift_Ins_p.V174fs|CALN1_ENST00000405452.2_Frame_Shift_Ins_p.V174fs	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	174						Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CCTTCAAACTCTGTTTGGCAGT	0.520													15	107	---	---	---	---					
OR1N1	138883	broad.mit.edu	37	9	125289197	125289197	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr9:125289197delG	ENST00000304880.2	-	1	375	c.376delC	c.(376-378)acfs	p.H126fs		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						CAGAGGGGGTGGCAAATGGCC	0.522													11	25	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61835089	61835100	+	In_Frame_Del	DEL	TGCTGCTGATTT	TGCTGCTGATTT	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr10:61835089_61835100delTGCTGCTGATTT	ENST00000280772.1	-	37	5730_5741	c.5539_5550delAAATCAGCAGCA	c.(5539-5550)del	p.KSAA1847del	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1847	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACAGCAAGGCTGCTGCTGATTTTGTAAATGAA	0.401													13	186	---	---	---	---					
OR8H2	390151	broad.mit.edu	37	11	55872707	55872707	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr11:55872707delC	ENST00000313503.1	+	1	189	c.189delC	c.(187-189)ttfs	p.F63fs		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TGTATTTTTTCCTTACTCACC	0.418										HNSCC(53;0.14)			52	307	---	---	---	---					
NCKAP1L	3071	broad.mit.edu	37	12	54929976	54929976	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:54929976delC	ENST00000293373.6	+	28	3099	c.3020delC	c.(3019-3021)tcfs	p.S1007fs	NCKAP1L_ENST00000545638.2_Frame_Shift_Del_p.S957fs	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1007					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CTGGCAGTTTCCCTCCCACTC	0.453													18	49	---	---	---	---					
CAND1	55832	broad.mit.edu	37	12	67700295	67700297	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr12:67700295_67700297delTGT	ENST00000545606.1	+	10	3284_3286	c.2847_2849delTGT	c.(2845-2850)aat>aa	p.NV949del		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	949					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GAACCAGAAATGTTGTTGCTGAA	0.414													14	51	---	---	---	---					
OR1A2	26189	broad.mit.edu	37	17	3101552	3101552	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:3101552delT	ENST00000381951.1	+	1	740	c.740delT	c.(739-741)gtfs	p.V247fs		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						CTCACAGTTGTTTTTTTATAT	0.453													16	87	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29657487	29657487	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr17:29657487delA	ENST00000358273.4	+	39	6166	c.5783delA	c.(5782-5784)gafs	p.E1929fs	NF1_ENST00000581113.2_3'UTR|NF1_ENST00000356175.3_Frame_Shift_Del_p.E1908fs	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1929					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GAATTTTTGGAAGAGTGTATT	0.338			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			19	63	---	---	---	---					
ATP9A	10079	broad.mit.edu	37	20	50255995	50255995	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr20:50255995delG	ENST00000338821.5	-	15	1819	c.1555delC	c.(1555-1557)gafs	p.R519fs	ATP9A_ENST00000311637.5_Frame_Shift_Del_p.R383fs|ATP9A_ENST00000402822.1_Frame_Shift_Del_p.R398fs	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	519					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GACTGGTCTCGGCCCACCAGG	0.547											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	69	---	---	---	---					
APOBEC3H	164668	broad.mit.edu	37	22	39497936	39497937	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chr22:39497936_39497937insT	ENST00000442487.3	+	4	559_560	c.432_433insT	c.(430-435)tggggafs	p.W144fs	APOBEC3H_ENST00000401756.1_Frame_Shift_Ins_p.W144fs|APOBEC3H_ENST00000421988.2_Intron|APOBEC3H_ENST00000348946.4_Frame_Shift_Ins_p.W144fs	NM_181773.3	NP_861438.2	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H	144					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			central_nervous_system(1)|kidney(8)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15	Melanoma(58;0.04)					TTGCTGACTGCTGGGAAAACTT	0.525													25	51	---	---	---	---					
TSIX	9383	broad.mit.edu	37	X	73047124	73047125	+	RNA	DEL	AC	AC	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	87619ebc-a51c-4b54-b911-d472f108df9e	g.chrX:73047124_73047125delAC	ENST00000604411.1	+	0	35085_35086				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCCACACATGACACACACACAC	0.470													7	75	---	---	---	---					
IFI44L	10964	broad.mit.edu	37	1	79102763	79102763	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:79102763delC	ENST00000370751.4	+	6	1102	c.923delC	c.(922-924)acfs	p.T308fs	IFI44L_ENST00000476521.1_Intron|IFI44L_ENST00000342282.3_Frame_Shift_Del_p.T50fs	NM_006820.2	NP_006811.2	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	308						cytoplasm				endometrium(4)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	22						ACTTTTATCACCTCTCCATCT	0.373													13	149	---	---	---	---					
PI4KB	5298	broad.mit.edu	37	1	151280136	151280136	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr1:151280136delG	ENST00000368875.2	-	5	1712	c.1132delC	c.(1132-1134)gafs	p.R378fs	PI4KB_ENST00000368872.1_Frame_Shift_Del_p.R351fs|PI4KB_ENST00000368874.4_Frame_Shift_Del_p.R351fs|PI4KB_ENST00000271657.5_Frame_Shift_Del_p.R378fs|PI4KB_ENST00000368873.1_Frame_Shift_Del_p.R366fs|PI4KB_ENST00000529142.1_Frame_Shift_Del_p.R34fs	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	366					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			AGCCAGACTCGGGCAGGGAGC	0.592													8	60	---	---	---	---					
CERS6	253782	broad.mit.edu	37	2	169574401	169574402	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr2:169574401_169574402insT	ENST00000305747.6	+	8	1345_1346	c.758_759insT	c.(757-759)tgcfs	p.C253fs	CERS6_ENST00000392687.4_Frame_Shift_Ins_p.C253fs	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	253	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										ATGGCAAATTATGCCAAGTTTC	0.351													27	34	---	---	---	---					
IKZF1	10320	broad.mit.edu	37	7	50468265	50468265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:50468265delG	ENST00000331340.3	+	8	1655	c.1500delG	c.(1498-1500)cafs	p.Q500fs	IKZF1_ENST00000440768.2_3'UTR|IKZF1_ENST00000346667.4_Frame_Shift_Del_p.Q270fs|IKZF1_ENST00000439701.1_Frame_Shift_Del_p.Q458fs|IKZF1_ENST00000357364.4_Frame_Shift_Del_p.Q413fs|IKZF1_ENST00000438033.1_Frame_Shift_Del_p.Q413fs|IKZF1_ENST00000359197.5_Frame_Shift_Del_p.Q458fs|IKZF1_ENST00000343574.5_Frame_Shift_Del_p.Q413fs|IKZF1_ENST00000349824.4_Frame_Shift_Del_p.Q357fs	NM_001220769.1|NM_001220772.1|NM_001220773.1|NM_001220775.1|NM_006060.4	NP_001207698.1|NP_001207701.1|NP_001207702.1|NP_001207704.1|NP_006051.1	Q13422	IKZF1_HUMAN	IKAROS family zinc finger 1 (Ikaros)	500					cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding	p.?(28)		haematopoietic_and_lymphoid_tissue(275)|lung(1)	276	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				ACCACAGCCAGGACCGGTACG	0.627			"""D,T"""	BCL6	"""ALL, DLBCL"""								7	25	---	---	---	---					
CALN1	83698	broad.mit.edu	37	7	71275333	71275334	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:71275333_71275334insT	ENST00000395275.2	-	6	1033_1034	c.645_646insA	c.(643-648)acagttfs	p.V216fs	CALN1_ENST00000329008.5_Frame_Shift_Ins_p.V174fs|CALN1_ENST00000431984.1_Frame_Shift_Ins_p.V174fs|CALN1_ENST00000412588.1_Frame_Shift_Ins_p.V216fs|CALN1_ENST00000405452.2_Frame_Shift_Ins_p.V174fs|CALN1_ENST00000395276.2_Frame_Shift_Ins_p.V174fs	NM_031468.3	NP_113656.2	Q9BXU9	CABP8_HUMAN	calneuron 1	174						Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(6)|lung(19)|skin(2)	32		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				CCTTCAAACTCTGTTTGGCAGT	0.520													15	107	---	---	---	---					
PMS2P3	5387	broad.mit.edu	37	7	75145720	75145721	+	RNA	DEL	AT	AT	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr7:75145720_75145721delAT	ENST00000418756.1	-	0	618					NR_028059.1															lung(1)	1						TCCTTTGGGGatatatatatat	0.302													2	4	---	---	---	---					
OR1N1	138883	broad.mit.edu	37	9	125289197	125289197	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr9:125289197delG	ENST00000304880.2	-	1	375	c.376delC	c.(376-378)acfs	p.H126fs		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						CAGAGGGGGTGGCAAATGGCC	0.522													11	25	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61835089	61835100	+	In_Frame_Del	DEL	TGCTGCTGATTT	TGCTGCTGATTT	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr10:61835089_61835100delTGCTGCTGATTT	ENST00000280772.1	-	37	5730_5741	c.5539_5550delAAATCAGCAGCA	c.(5539-5550)del	p.KSAA1847del	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1847	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						ACAGCAAGGCTGCTGCTGATTTTGTAAATGAA	0.401													13	186	---	---	---	---					
OR8H2	390151	broad.mit.edu	37	11	55872707	55872707	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr11:55872707delC	ENST00000313503.1	+	1	189	c.189delC	c.(187-189)ttfs	p.F63fs		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TGTATTTTTTCCTTACTCACC	0.418										HNSCC(53;0.14)			52	307	---	---	---	---					
NCKAP1L	3071	broad.mit.edu	37	12	54929976	54929976	+	Frame_Shift_Del	DEL	C	C	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:54929976delC	ENST00000293373.6	+	28	3099	c.3020delC	c.(3019-3021)tcfs	p.S1007fs	NCKAP1L_ENST00000545638.2_Frame_Shift_Del_p.S957fs	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	1007					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CTGGCAGTTTCCCTCCCACTC	0.453													18	49	---	---	---	---					
CAND1	55832	broad.mit.edu	37	12	67700295	67700297	+	In_Frame_Del	DEL	TGT	TGT	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr12:67700295_67700297delTGT	ENST00000545606.1	+	10	3284_3286	c.2847_2849delTGT	c.(2845-2850)aat>aa	p.NV949del		NM_018448.3	NP_060918.2	Q86VP6	CAND1_HUMAN	cullin-associated and neddylation-dissociated 1	949					cell differentiation|negative regulation of catalytic activity|protein ubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|ubiquitin ligase complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(12)|prostate(1)|skin(2)|stomach(1)	35			GBM - Glioblastoma multiforme(1;1.13e-10)|Lung(24;0.000342)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(28;0.0279)		GAACCAGAAATGTTGTTGCTGAA	0.414													14	51	---	---	---	---					
OR1A2	26189	broad.mit.edu	37	17	3101552	3101552	+	Frame_Shift_Del	DEL	T	T	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:3101552delT	ENST00000381951.1	+	1	740	c.740delT	c.(739-741)gtfs	p.V247fs		NM_012352.1	NP_036484.1	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A, member 2	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(2)|lung(5)|skin(4)|stomach(2)	18						CTCACAGTTGTTTTTTTATAT	0.453													16	87	---	---	---	---					
NF1	4763	broad.mit.edu	37	17	29657487	29657487	+	Frame_Shift_Del	DEL	A	A	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr17:29657487delA	ENST00000358273.4	+	39	6166	c.5783delA	c.(5782-5784)gafs	p.E1929fs	NF1_ENST00000356175.3_Frame_Shift_Del_p.E1908fs|NF1_ENST00000581113.2_3'UTR	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1929					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		GAATTTTTGGAAGAGTGTATT	0.338			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			19	63	---	---	---	---					
ATP9A	10079	broad.mit.edu	37	20	50255995	50255995	+	Frame_Shift_Del	DEL	G	G	-			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr20:50255995delG	ENST00000338821.5	-	15	1819	c.1555delC	c.(1555-1557)gafs	p.R519fs	ATP9A_ENST00000402822.1_Frame_Shift_Del_p.R398fs|ATP9A_ENST00000311637.5_Frame_Shift_Del_p.R383fs	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	519					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GACTGGTCTCGGCCCACCAGG	0.547											OREG0026043	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	69	---	---	---	---					
APOBEC3H	164668	broad.mit.edu	37	22	39497936	39497937	+	Frame_Shift_Ins	INS	-	-	T			TCGA-44-7667-01A-31D-2063-08	TCGA-44-7667-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d2ebef2-26f9-4b4f-95b6-82d056051c52	8b0dc33d-8b95-45fd-a42c-727dfce90ac1	g.chr22:39497936_39497937insT	ENST00000442487.3	+	4	559_560	c.432_433insT	c.(430-435)tggggafs	p.W144fs	APOBEC3H_ENST00000401756.1_Frame_Shift_Ins_p.W144fs|APOBEC3H_ENST00000421988.2_Intron|APOBEC3H_ENST00000348946.4_Frame_Shift_Ins_p.W144fs	NM_181773.3	NP_861438.2	Q6NTF7	ABC3H_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H	144					DNA cytosine deamination|negative regulation of retroviral genome replication|negative regulation of transposition	cytoplasm|nucleus	cytidine deaminase activity|zinc ion binding			central_nervous_system(1)|kidney(8)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15	Melanoma(58;0.04)					TTGCTGACTGCTGGGAAAACTT	0.525													25	51	---	---	---	---					
