Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TFCP2	7024	broad.mit.edu	37	12	51501129	51501129	+	Splice_Site	SNP	G	G	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr12:51501129G>C	ENST00000307660.4	-	6	1285	c.564_splice	c.e6-1	p.P189_splice	TFCP2_ENST00000549867.1_Splice_Site_p.P240_splice|TFCP2_ENST00000548115.1_Splice_Site_p.P189_splice|TFCP2_ENST00000257915.5_Splice_Site_p.P240_splice	NM_001173453.1	NP_001166924.1	Q12800	TFCP2_HUMAN	transcription factor CP2	240	DNA-binding.				regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)	23						GCACCTTTGGGCTGAAATGAG	0.333000													65	138					0	0	0.003610	0	0
ZNF66	7617	broad.mit.edu	37	19	20976601	20976601	+	Nonsense_Mutation	SNP	C	C	G			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr19:20976601C>G	ENST00000344519.8	+	3	166	c.143C>G	c.(142-144)tCa>tGa	p.S48*	ZNF66_ENST00000425625.1_Nonsense_Mutation_p.S94*|ZNF66_ENST00000360204.5_Nonsense_Mutation_p.S26*|ZNF66_ENST00000594534.1_Nonsense_Mutation_p.S48*														p.S94*(1)|p.S48*(1)									ATTGTTGTCTCAAAGCCAGAC	0.398000													11	172					0	0	0.001855	0	0
GNL1	2794	broad.mit.edu	37	6	30522868	30522868	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr6:30522868C>G	ENST00000376621.3	-	3	1310	c.340G>C	c.(340-342)Gag>Cag	p.E114Q		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	114					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity	p.E114Q(1)		cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						ATGTCCAGCTCCAACAACTCA	0.552000													14	97					0	0	0.001855	0	0
CLTC	1213	broad.mit.edu	37	17	57762973	57762973	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr17:57762973C>G	ENST00000269122.3	+	30	4905	c.4631C>G	c.(4630-4632)tCt>tGt	p.S1544C	CLTC_ENST00000579456.1_Missense_Mutation_p.S481C|CLTC_ENST00000393043.1_Missense_Mutation_p.S1544C	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	1544	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity	p.S1544C(1)	CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GCTTCTGAATCTAAAGATACT	0.368000			T	"""ALK, TFE3"""	"""ALCL, renal """								9	141					0	0	0.006214	0	0
REV3L	5980	broad.mit.edu	37	6	111632428	111632428	+	Missense_Mutation	SNP	G	G	A	rs142379750		TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr6:111632428G>A	ENST00000435970.1	-	31	9221	c.8405C>T	c.(8404-8406)aCg>aTg	p.T2802M	REV3L_ENST00000462119.1_5'UTR|RP5-1112D6.8_ENST00000607434.1_RNA|REV3L_ENST00000368802.3_Missense_Mutation_p.T2880M|REV3L_ENST00000358835.3_Missense_Mutation_p.T2880M|REV3L_ENST00000368805.1_Missense_Mutation_p.T2880M			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2880					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding	p.T2802M(1)|p.T2880M(1)		NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		TATATCTCTCGTTTCAAATAG	0.333000								DNA polymerases (catalytic subunits)					39	243					0	0	0.006999	0	0
C11orf1	64776	broad.mit.edu	37	11	111753869	111753869	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr11:111753869T>G	ENST00000260276.3	+	3	623	c.286T>G	c.(286-288)Tac>Gac	p.Y96D	C11orf1_ENST00000530214.1_Intron|C11orf1_ENST00000528125.1_Missense_Mutation_p.Y50D|C11orf1_ENST00000529270.1_Missense_Mutation_p.Y136D	NM_022761.2	NP_073598.1	Q9H5F2	CK001_HUMAN	chromosome 11 open reading frame 1	96						nucleus		p.Y96D(1)		kidney(2)|lung(3)	5		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		GTTTGGACACTACTTTGAAAC	0.333000													3	15					0	0	0.004672	0	0
RSPH10B2	728194	broad.mit.edu	37	7	6803562	6803562	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr7:6803562G>A	ENST00000403107.1	+	5	790	c.403G>A	c.(403-405)Gac>Aac	p.D135N	RSPH10B2_ENST00000359718.3_5'UTR|RSPH10B2_ENST00000463354.2_3'UTR|RSPH10B2_ENST00000297186.3_Missense_Mutation_p.D135N|RSPH10B2_ENST00000404077.1_Missense_Mutation_p.D135N|RSPH10B2_ENST00000433859.2_Missense_Mutation_p.D135N					radial spoke head 10 homolog B2 (Chlamydomonas)									p.D135N(2)		breast(3)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|skin(2)	15						GCTTCAGGGCGACTTTGTGAA	0.612000													5	41					0	0	0.001984	0	0
ACP2	53	broad.mit.edu	37	11	47261720	47261720	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr11:47261720G>A	ENST00000256997.3	-	11	1335	c.1219C>T	c.(1219-1221)Cag>Tag	p.Q407*	ACP2_ENST00000537863.1_Nonsense_Mutation_p.Q220*|ACP2_ENST00000529444.1_Nonsense_Mutation_p.Q344*|ACP2_ENST00000533929.1_Nonsense_Mutation_p.Q379*|ACP2_ENST00000525230.1_5'UTR|ACP2_ENST00000527256.1_Nonsense_Mutation_p.Q375*	NM_001610.2	NP_001601.1	P11117	PPAL_HUMAN	acid phosphatase 2, lysosomal	407						integral to membrane|lysosomal lumen|lysosomal membrane	acid phosphatase activity	p.Q407*(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)	10						GGCTGGGCCTGCATCCGGAAG	0.642000													29	55					0	0	0.005443	0	0
KEL	3792	broad.mit.edu	37	7	142640391	142640391	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr7:142640391G>A	ENST00000355265.2	-	16	2217	c.1743C>T	c.(1741-1743)caC>caT	p.H581H		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	581					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding	p.H581H(1)		central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GCAACAGCTCGTGGGCCATGA	0.557000													7	23					0	0	0.001984	0	0
PLXNA3	55558	broad.mit.edu	37	X	153698805	153698805	+	Silent	SNP	G	G	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chrX:153698805G>C	ENST00000369682.3	+	30	5182	c.5007G>C	c.(5005-5007)gtG>gtC	p.V1669V	PLXNA3_ENST00000493546.1_3'UTR	NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1669					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity	p.V1669V(1)		breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGAAGTTCGTGGATGACCTCT	0.607000													27	52					0	0	0.005443	0	0
SMAD9	4093	broad.mit.edu	37	13	37427571	37427571	+	Silent	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr13:37427571C>T	ENST00000379826.4	-	6	1587	c.1245G>A	c.(1243-1245)cgG>cgA	p.R415R	SMAD9_ENST00000399275.2_Silent_p.R415R|SMAD9_ENST00000350148.5_Silent_p.R378R	NM_001127217.2	NP_001120689.1	O15198	SMAD9_HUMAN	SMAD family member 9	415	MH2.				BMP signaling pathway|transforming growth factor beta receptor signaling pathway	cytosol|transcription factor complex	sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity	p.R378R(1)|p.R415R(1)		NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)	18		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)		all cancers(112;3.38e-07)|Epithelial(112;1.93e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00804)|BRCA - Breast invasive adenocarcinoma(63;0.0129)|GBM - Glioblastoma multiforme(144;0.026)		CAAAACTCATCCGGATAGTAC	0.448000													8	31					0	0	0.004482	0	0
BPIFB1	92747	broad.mit.edu	37	20	31890785	31890785	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr20:31890785T>C	ENST00000253354.1	+	11	1206	c.1045T>C	c.(1045-1047)Ttt>Ctt	p.F349L	BPIFB1_ENST00000464032.1_3'UTR	NM_033197.2	NP_149974.2	Q8TDL5	LPLC1_HUMAN	BPI fold containing family B, member 1	349						extracellular space	lipid binding	p.F349L(1)									TCCCGAGTTTTTTATAGACCA	0.547000													13	61					0	0	0.003163	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240795	39240795	+	Missense_Mutation	SNP	A	A	T	rs9894966	by1000genomes	TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr17:39240795A>T	ENST00000391417.4	+	1	337	c.337A>T	c.(337-339)Agc>Tgc	p.S113C		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.R111_C115delRPSCC(1)|p.S113C(1)|p.?(1)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						ctgccgccccagctgctgccg	0.667000													3	9					0	0	0.004672	0	0
STAC	6769	broad.mit.edu	37	3	36484872	36484872	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr3:36484872G>A	ENST00000273183.3	+	2	428	c.128G>A	c.(127-129)cGa>cAa	p.R43Q	STAC_ENST00000476388.1_3'UTR|STAC_ENST00000457375.2_Missense_Mutation_p.R43Q	NM_003149.1	NP_003140.1	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	43					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding	p.R43Q(2)		endometrium(5)|large_intestine(9)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(5)	32						AAACTAAAACGATCACTTTCT	0.468000													4	23					0	0	0.000248	0	0
ATP2A2	488	broad.mit.edu	37	12	110783813	110783813	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr12:110783813G>A	ENST00000395494.2	+	18	3231	c.2668G>A	c.(2668-2670)Gaa>Aaa	p.E890K	ATP2A2_ENST00000308664.6_Missense_Mutation_p.E917K|ATP2A2_ENST00000539276.2_Missense_Mutation_p.E917K			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	917					ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding	p.E917K(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						CAGCTTGTCCGAAAACCAGTC	0.567000													9	52					0	0	0.006214	0	0
RFPL1	5988	broad.mit.edu	37	22	29834951	29834951	+	Silent	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr22:29834951C>T	ENST00000354373.2	+	1	380	c.171C>T	c.(169-171)tgC>tgT	p.C57C	RFPL1S_ENST00000461286.2_RNA	NM_021026.2	NP_066306.2	O75677	RFPL1_HUMAN	ret finger protein-like 1	57							zinc ion binding	p.C57C(1)		endometrium(3)|large_intestine(1)|lung(6)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	16						AGTGTGGATGCGCTGTCTGCT	0.512000													4	101					0	0	0.000248	0	0
NLGN2	57555	broad.mit.edu	37	17	7311965	7311965	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr17:7311965G>A	ENST00000302926.2	+	1	464	c.391G>A	c.(391-393)Gcc>Acc	p.A131T	NLGN2_ENST00000575301.1_Missense_Mutation_p.A131T	NM_020795.2	NP_065846.1	Q8NFZ4	NLGN2_HUMAN	neuroligin 2	131					cell-cell junction maintenance|neuron cell-cell adhesion|positive regulation of synaptogenesis|regulation of inhibitory postsynaptic membrane potential|synapse assembly	cell surface|integral to plasma membrane|postsynaptic membrane	neurexin binding|receptor activity	p.A131T(1)		central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|prostate(2)|skin(3)	22		Prostate(122;0.157)				GGAGGCGGCCGCCACCTACGT	0.687000													3	22					0	0	0.004672	0	0
TTC13	79573	broad.mit.edu	37	1	231064840	231064840	+	Splice_Site	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:231064840C>T	ENST00000366661.4	-	12	1308		c.e12-1		TTC13_ENST00000366662.4_Splice_Site|TTC13_ENST00000414259.1_Splice_Site	NM_024525.4	NP_078801.3	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13								binding	p.?(1)		central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	39	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		CGAGAATACTCTGCAGAAAGG	0.398000													27	46					0	0	0.007291	0	0
MIR101-1	406893	broad.mit.edu	37	1	65524127	65524127	+	RNA	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:65524127C>T	ENST00000362265.1	-	0	64					NR_029516.1																						TGCCATCCTTCAGTTATCACA	0.502000													11	52					0	0	0.000978	0	0
CACNA1E	777	broad.mit.edu	37	1	181708389	181708389	+	Splice_Site	SNP	C	C	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:181708389C>A	ENST00000526775.1	+	24	3827	c.3662_splice	c.e24+1	p.A1221_splice	CACNA1E_ENST00000358338.5_Splice_Site_p.A1172_splice|CACNA1E_ENST00000367567.4_Splice_Site_p.A847_splice|CACNA1E_ENST00000357570.5_Splice_Site_p.A1191_splice|CACNA1E_ENST00000367573.2_Splice_Site_p.A1240_splice|CACNA1E_ENST00000367570.1_Splice_Site_p.A1240_splice|CACNA1E_ENST00000360108.3_Splice_Site_p.A1221_splice	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1240					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.A1240E(2)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TTTGCTCTGGCGTAAGTGACT	0.507000													5	162					4.096e-09	5.66076e-09	0.001168	1	0
LILRA1	11024	broad.mit.edu	37	19	55107879	55107879	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr19:55107879A>C	ENST00000251372.3	+	7	1366	c.1184A>C	c.(1183-1185)tAc>tCc	p.Y395S	LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000453777.1_Intron|LILRB1_ENST00000418536.2_Intron	NM_006863.1	NP_006854.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	395	Ig-like C2-type 4.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity	p.Y395S(1)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		TCGGGGACCTACAGGTGCTAC	0.587000													7	248					0	0	0.004482	0	0
HMCN1	83872	broad.mit.edu	37	1	186057109	186057109	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:186057109G>T	ENST00000271588.4	+	61	9638	c.9409G>T	c.(9409-9411)Gga>Tga	p.G3137*	HMCN1_ENST00000367492.2_Nonsense_Mutation_p.G3137*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3137	Ig-like C2-type 29.				response to stimulus|visual perception	basement membrane	calcium ion binding	p.G3137*(1)		NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AAATGTAGCAGGACGGGATGA	0.353000													7	80					8.12818e-05	0.000109864	0.001984	1	0
WASF1	8936	broad.mit.edu	37	6	110424684	110424684	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr6:110424684G>C	ENST00000392589.1	-	9	1626	c.790C>G	c.(790-792)Ctg>Gtg	p.L264V	WASF1_ENST00000359451.2_Missense_Mutation_p.L264V|WASF1_ENST00000392587.2_Missense_Mutation_p.L264V|WASF1_ENST00000392588.1_Missense_Mutation_p.L264V|WASF1_ENST00000392586.1_Missense_Mutation_p.L264V	NM_003931.2	NP_003922.1	Q92558	WASF1_HUMAN	WAS protein family, member 1	264					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding	p.L264V(1)		breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		GCTCTAGTCAGAAGCTCACTC	0.443000													5	111					0	0	0.000602	0	0
KCNJ4	3761	broad.mit.edu	37	22	38824042	38824042	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr22:38824042G>A	ENST00000303592.3	-	2	354	c.96C>T	c.(94-96)ttC>ttT	p.F32F		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	32					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding	p.F32F(1)		endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					TCAGGTTGGCGAAGTACACGT	0.627000													63	211					0	0	0.003610	0	0
C14orf166B	145497	broad.mit.edu	37	14	77327095	77327095	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr14:77327095G>A	ENST00000393774.3	+	11	1288	c.1164G>A	c.(1162-1164)ccG>ccA	p.P388P		NM_194287.2	NP_919263.2	Q0VAA2	CN16B_HUMAN	chromosome 14 open reading frame 166B	388								p.P388P(2)		breast(1)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(1)	18			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0306)		CCGTTCACCCGCAGCTGGACG	0.537000													14	67					0	0	0.002450	0	0
PPFIA1	8500	broad.mit.edu	37	11	70172763	70172763	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr11:70172763G>A	ENST00000253925.7	+	7	984	c.769G>A	c.(769-771)Gaa>Aaa	p.E257K	AP000487.6_ENST00000528607.1_RNA|PPFIA1_ENST00000389547.3_Missense_Mutation_p.E257K|CTA-797E19.2_ENST00000526017.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	257					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity	p.E257K(1)		breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TGAGCTCCAAGAAATCATAAG	0.438000													103	259					0	0	0.003610	0	0
NXPE1	120400	broad.mit.edu	37	11	114393191	114393191	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr11:114393191G>C	ENST00000536271.1	-	4	1534	c.291C>G	c.(289-291)atC>atG	p.I97M	NXPE1_ENST00000251921.2_Missense_Mutation_p.I239M|NXPE1_ENST00000424269.1_Missense_Mutation_p.I381M					neurexophilin and PC-esterase domain family, member 1									p.I239M(1)									GTTTCTTAAAGATTCCAGTTT	0.323000													15	70					0	0	0.002450	0	0
VIL1	7429	broad.mit.edu	37	2	219301247	219301247	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr2:219301247G>A	ENST00000248444.5	+	16	1957	c.1869G>A	c.(1867-1869)gaG>gaA	p.E623E	VIL1_ENST00000392114.2_Silent_p.E312E	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	623	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity	p.E623E(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCTCTTTGAGTGTTCCAACA	0.507000													89	153					0	0	0.003610	0	0
KCNJ15	3772	broad.mit.edu	37	21	39671440	39671440	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr21:39671440A>G	ENST00000398930.1	+	4	611	c.257A>G	c.(256-258)tAt>tGt	p.Y86C	KCNJ15_ENST00000328656.3_Missense_Mutation_p.Y86C|KCNJ15_ENST00000398938.2_Missense_Mutation_p.Y86C|KCNJ15_ENST00000398932.1_Missense_Mutation_p.Y86C|KCNJ15_ENST00000398934.1_Missense_Mutation_p.Y86C			Q99712	IRK15_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 15	86					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity	p.Y86C(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	24						GTCATCTACTATGCCATCGCG	0.488000													54	213					0	0	0.003610	0	0
GMEB2	26205	broad.mit.edu	37	20	62234341	62234341	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr20:62234341C>T	ENST00000266068.1	-	3	812	c.334G>A	c.(334-336)Ggc>Agc	p.G112S	GMEB2_ENST00000370069.1_Missense_Mutation_p.G61S|GMEB2_ENST00000370077.1_Missense_Mutation_p.G112S			Q9UKD1	GMEB2_HUMAN	glucocorticoid modulatory element binding protein 2	112	SAND.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|metal ion binding	p.G112S(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	18	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;4.79e-09)|all cancers(9;2.76e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.0114)			ACATTGATGCCGGGACACACA	0.557000													15	119					0	0	0.004007	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811410	5811410	+	Nonsense_Mutation	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chrX:5811410C>T	ENST00000381095.3	-	6	2526	c.1899G>A	c.(1897-1899)tgG>tgA	p.W633*	NLGN4X_ENST00000538097.1_Nonsense_Mutation_p.W633*|NLGN4X_ENST00000381092.1_Nonsense_Mutation_p.W633*|NLGN4X_ENST00000275857.6_Nonsense_Mutation_p.W633*|NLGN4X_ENST00000381093.2_Nonsense_Mutation_p.W653*	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	633					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity	p.W633*(1)		breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						TGGTGGTTGGCCATATCTTGG	0.498000													37	1218					0	0	0.003954	0	0
SPTA1	6708	broad.mit.edu	37	1	158631093	158631093	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:158631093G>T	ENST00000368148.3	-	18	2751	c.2571C>A	c.(2569-2571)aaC>aaA	p.N857K	SPTA1_ENST00000368147.3_Missense_Mutation_p.N857K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	857					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton	p.N857K(1)		NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					CTACCATTTTGTTTCCCCTTT	0.433000													83	131					1.59627e-33	2.28304e-33	0.003610	1	0
PORCN	64840	broad.mit.edu	37	X	48368171	48368171	+	Splice_Site	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chrX:48368171G>A	ENST00000359882.4	+	2	142		c.e2-1		PORCN_ENST00000355092.3_Intron|PORCN_ENST00000355961.4_Splice_Site|PORCN_ENST00000537758.1_Splice_Site|PORCN_ENST00000361988.3_Splice_Site|PORCN_ENST00000326194.6_5'UTR|PORCN_ENST00000367574.4_5'UTR|PORCN_ENST00000486272.1_Intron			Q9H237	PORCN_HUMAN	porcupine homolog (Drosophila)						Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGCTTTGACAGATCTATCCAT	0.577000													3	21					0	0	0.004672	0	0
PDXDC1	23042	broad.mit.edu	37	16	15102638	15102638	+	Silent	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr16:15102638C>T	ENST00000396410.4	+	7	679	c.582C>T	c.(580-582)ctC>ctT	p.L194L	PDXDC1_ENST00000563679.1_Silent_p.L212L|PDXDC1_ENST00000325823.7_Silent_p.L179L|PDXDC1_ENST00000569715.1_Silent_p.L167L|PDXDC1_ENST00000455313.2_Intron|PDXDC1_ENST00000450288.2_Silent_p.L166L|PDXDC1_ENST00000535621.2_Silent_p.L194L|PDXDC1_ENST00000447912.2_Silent_p.L103L	NM_015027.2	NP_055842.2	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain containing 1	194					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding	p.L194L(1)		central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	TCCTGCAGCTCGGCTTGCCCT	0.458000													6	351					0	0	0.001984	0	0
ADCY3	109	broad.mit.edu	37	2	25057771	25057771	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr2:25057771C>T	ENST00000260600.5	-	9	2548	c.1697G>A	c.(1696-1698)aGg>aAg	p.R566K	ADCY3_ENST00000405392.1_Missense_Mutation_p.R199K	NM_004036.3	NP_004027.2	O60266	ADCY3_HUMAN	adenylate cyclase 3	566					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|sensory perception of smell|synaptic transmission|transmembrane transport|water transport	cytoplasm|integral to plasma membrane	ATP binding|calmodulin binding|metal ion binding	p.R566K(1)		NS(1)|breast(5)|endometrium(7)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(4)|skin(2)	44	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.203)					CAGGCGCAGCCTCCGGCGTGG	0.642000													9	30					0	0	0.004482	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144874795	144874795	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:144874795G>A	ENST00000369359.4	-	33	5259	c.5221C>T	c.(5221-5223)Cgc>Tgc	p.R1741C	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R1605C|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.R1605C|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.R1561C|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R1741C			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1605					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding	p.R1605C(2)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTGGGAGAGCGGTGGGAGTCA	0.547000			T	PDGFRB	MPD								66	252					0	0	0.003610	0	0
DAW1	164781	broad.mit.edu	37	2	228762983	228762983	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr2:228762983C>T	ENST00000373666.2	+	6	1162	c.526C>T	c.(526-528)Cat>Tat	p.H176Y	DAW1_ENST00000545118.1_Missense_Mutation_p.H161Y|DAW1_ENST00000309931.2_Missense_Mutation_p.H176Y					dynein assembly factor with WDR repeat domains 1									p.H176Y(1)									CTTCAGGGGTCATACAGCAGA	0.333000													10	54					0	0	0.008291	0	0
C20orf195	79025	broad.mit.edu	37	20	62187706	62187706	+	Silent	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr20:62187706C>T	ENST00000370098.3	+	2	782	c.690C>T	c.(688-690)gtC>gtT	p.V230V	C20orf195_ENST00000370097.1_Silent_p.V230V	NM_024059.2	NP_076964.1	Q9BVV2	CT195_HUMAN	chromosome 20 open reading frame 195	230								p.V230V(1)		large_intestine(3)|lung(4)	7	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;9.69e-09)|all cancers(9;5.84e-08)|BRCA - Breast invasive adenocarcinoma(10;3.63e-06)			GCTGGTTCGTCACCATCCAGC	0.647000													39	125					0	0	0.006999	0	0
BRIP1	83990	broad.mit.edu	37	17	59857699	59857699	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr17:59857699T>C	ENST00000259008.2	-	13	2125	c.1858A>G	c.(1858-1860)Atg>Gtg	p.M620V	BRIP1_ENST00000577598.1_Missense_Mutation_p.M620V	NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	620					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding	p.M620V(2)		NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						AAGGATTTCATTGGTGATAAT	0.303000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					4	211					0	0	0.000248	0	0
TPR	7175	broad.mit.edu	37	1	186324846	186324846	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:186324846G>A	ENST00000367478.3	-	16	2239	c.1943C>T	c.(1942-1944)tCa>tTa	p.S648L	TPR_ENST00000474852.1_5'UTR	NM_003292.2	NP_003283.2	P12270	TPR_HUMAN	translocated promoter region, nuclear basket protein	648					carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity	p.S648L(1)|p.S649L(1)		autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(9)|kidney(12)|large_intestine(23)|liver(1)|lung(45)|ovary(2)|pancreas(1)|prostate(6)|skin(3)|stomach(1)|urinary_tract(8)	123		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		AACAGTCTGTGATGTACTTGG	0.408000			T	NTRK1	papillary thyroid								30	70					0	0	0.008361	0	0
EIF2S3	1968	broad.mit.edu	37	X	24094881	24094881	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chrX:24094881G>T	ENST00000253039.4	+	12	1651	c.1398G>T	c.(1396-1398)aaG>aaT	p.K466N	RP11-479I1.4_ENST00000457332.1_RNA	NM_001415.3	NP_001406.1	P41091	IF2G_HUMAN	eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa	466						cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity	p.K466N(1)		breast(1)|cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(1)	12						TGACAATCAAGCCAACAGTAG	0.343000													54	1270					4.67007e-22	6.60251e-22	0.008740	1	0
PLCB1	23236	broad.mit.edu	37	20	8782791	8782791	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr20:8782791T>C	ENST00000378641.3	+	32	3987	c.3512T>C	c.(3511-3513)cTc>cCc	p.L1171P	PLCB1_ENST00000378637.2_Missense_Mutation_p.L1171P|PLCB1_ENST00000338037.6_Intron	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	0					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity	p.L1171P(1)		NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CCTCAAGCTCTCAAGTGGTGA	0.552000													9	46					0	0	0.004482	0	0
EPB41L1	2036	broad.mit.edu	37	20	34797690	34797690	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr20:34797690C>T	ENST00000338074.2	+	15	2110	c.1949C>T	c.(1948-1950)tCg>tTg	p.S650L	EPB41L1_ENST00000479336.1_3'UTR|EPB41L1_ENST00000373946.3_Intron|EPB41L1_ENST00000373941.1_Missense_Mutation_p.S650L|EPB41L1_ENST00000373950.2_Missense_Mutation_p.S541L|EPB41L1_ENST00000441639.1_Missense_Mutation_p.S576L|EPB41L1_ENST00000202028.5_Missense_Mutation_p.S576L	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	650					cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity	p.S650L(1)|p.S939L(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					AAAAGCGACTCGGACACTGAG	0.632000													9	29					0	0	0.004482	0	0
USH2A	7399	broad.mit.edu	37	1	215963479	215963479	+	Silent	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:215963479C>T	ENST00000366943.2	-	51	10490	c.10104G>A	c.(10102-10104)caG>caA	p.Q3368Q	USH2A_ENST00000307340.3_Silent_p.Q3368Q			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3368					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.Q3368Q(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TACAGCATTTCTGGCTCTTTG	0.388000										HNSCC(13;0.011)			20	70					0	0	0.002780	0	0
SP7	121340	broad.mit.edu	37	12	53723126	53723126	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr12:53723126G>A	ENST00000536324.2	-	3	383	c.100C>T	c.(100-102)Cgg>Tgg	p.R34W	SP7_ENST00000303846.3_Missense_Mutation_p.R34W|SP7_ENST00000537210.2_Missense_Mutation_p.R16W	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	34					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R34W(1)		cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						GTTGAGTCCCGCAGAGGGCTA	0.577000													4	83					0	0	0.000248	0	0
BTN2A1	11120	broad.mit.edu	37	6	26466290	26466290	+	Splice_Site	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr6:26466290G>A	ENST00000429381.1	+	7	1168	c.955_splice	c.e7-1	p.R319_splice	BTN2A1_ENST00000312541.5_Splice_Site_p.R319_splice|BTN2A1_ENST00000469185.1_Splice_Site_p.R319_splice|BTN2A1_ENST00000541522.1_Splice_Site_p.R258_splice			Q7KYR7	BT2A1_HUMAN	butyrophilin, subfamily 2, member A1	319	B30.2/SPRY.				lipid metabolic process	integral to plasma membrane		p.R305Q(1)|p.R319Q(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(3)	27						TCCCTTGCAGGATGGAGAAGA	0.448000													24	160					0	0	0.003330	0	0
COL6A3	1293	broad.mit.edu	37	2	238280361	238280361	+	Silent	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr2:238280361C>T	ENST00000392004.3	-	8	3935	c.3681G>A	c.(3679-3681)gcG>gcA	p.A1227A	COL6A3_ENST00000409809.1_Intron|COL6A3_ENST00000347401.3_Intron|COL6A3_ENST00000346358.4_Intron|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000295550.4_Intron|COL6A3_ENST00000392003.2_Silent_p.A1026A|COL6A3_ENST00000353578.4_Intron	NM_057165.4	NP_476506.3	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1434	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.A1227A(1)		breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GAACCTCCGACGCCCCCATCT	0.473000													28	66					0	0	0.007291	0	0
ZNF483	158399	broad.mit.edu	37	9	114293154	114293154	+	Splice_Site	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr9:114293154G>A	ENST00000309235.5	+	3	570		c.e3-1		ZNF483_ENST00000358151.4_Splice_Site|ZNF483_ENST00000355824.3_Splice_Site	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483						viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						CCCTTTCCTAGATCCAGTCTC	0.333000													15	88					0	0	0.003163	0	0
HLA-A	3105	broad.mit.edu	37	6	29911194	29911194	+	Nonsense_Mutation	SNP	C	C	T	rs41541518		TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr6:29911194C>T	ENST00000396634.1	+	5	834	c.493C>T	c.(493-495)Cag>Tag	p.Q165*	HLA-A_ENST00000376802.2_Nonsense_Mutation_p.Q165*|HLA-A_ENST00000376809.5_Nonsense_Mutation_p.Q165*|HLA-A_ENST00000376806.5_Nonsense_Mutation_p.Q165*			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	165	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.Q165*(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						CATGGCGGCTCAGATCACCAA	0.652000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			9	28					0	0	0.004482	0	0
XRN1	54464	broad.mit.edu	37	3	142133085	142133085	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr3:142133085G>A	ENST00000264951.4	-	14	1602	c.1485C>T	c.(1483-1485)atC>atT	p.I495I	XRN1_ENST00000392981.2_Silent_p.I495I	NM_019001.3	NP_061874.3	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1	495					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding	p.I495I(1)		NS(1)|breast(3)|endometrium(6)|kidney(12)|large_intestine(11)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	61						TGAGTGTACTGATGTTGTGTA	0.343000													16	79					0	0	0.004990	0	0
PMP22	5376	broad.mit.edu	37	17	15142888	15142888	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr17:15142888G>A	ENST00000494511.1	-	2	206	c.40C>T	c.(40-42)Cat>Tat	p.H14Y	PMP22_ENST00000426385.3_Silent_p.I73I|PMP22_ENST00000395936.1_Silent_p.I73I|PMP22_ENST00000395938.2_Silent_p.I73I|PMP22_ENST00000312280.3_Silent_p.I73I			Q01453	PMP22_HUMAN	peripheral myelin protein 22	0					peripheral nervous system development|synaptic transmission	integral to membrane		p.I73I(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(3)	8				UCEC - Uterine corpus endometrioid carcinoma (92;0.0884)|BRCA - Breast invasive adenocarcinoma(8;4.92e-06)		TGCTGAAGATGATCGACAGGA	0.542000													11	43					0	0	0.008291	0	0
LRP1	4035	broad.mit.edu	37	12	57539234	57539234	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr12:57539234G>A	ENST00000243077.3	+	6	1268	c.802G>A	c.(802-804)Gtg>Atg	p.V268M	LRP1_ENST00000554174.1_Missense_Mutation_p.V268M|LRP1_ENST00000553277.1_Missense_Mutation_p.V268M|RP11-545N8.3_ENST00000555461.1_RNA|LRP1_ENST00000338962.4_Missense_Mutation_p.V268M	NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	268					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity	p.V268M(1)		NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AAAGGGCTTCGTGGATGAGCA	0.597000													9	110					0	0	0.006214	0	0
KLHL4	56062	broad.mit.edu	37	X	86924389	86924389	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chrX:86924389C>A	ENST00000373114.4	+	11	2238	c.2158C>A	c.(2158-2160)Cac>Aac	p.H720N	KLHL4_ENST00000373119.4_3'UTR	NM_057162.2	NP_476503.1	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	0						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding	p.H720N(1)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						GACTCTGGGGCACTAAATTCA	0.428000													3	34					1.23904e-05	1.69335e-05	0.000602	1	0
C2orf71	388939	broad.mit.edu	37	2	29296770	29296770	+	Missense_Mutation	SNP	C	C	G	rs140625913	by1000genomes	TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr2:29296770C>G	ENST00000331664.5	-	1	357	c.358G>C	c.(358-360)Ggt>Cgt	p.G120R		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	120					response to stimulus|visual perception	photoreceptor outer segment		p.G120R(1)		NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CCATGGGAACCCTGTGTCTTG	0.453000													57	125					0	0	0.003610	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145773476	145773476	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr8:145773476C>T	ENST00000276826.5	-	4	1195	c.994G>A	c.(994-996)Gtg>Atg	p.V332M	ARHGAP39_ENST00000377307.2_Missense_Mutation_p.V332M|ARHGAP39_ENST00000540274.1_Missense_Mutation_p.V332M			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	332	Pro-rich.				axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity	p.V332M(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						TCGAATTGCACGTCCATGGGG	0.706000													17	20					0	0	0.004990	0	0
TRIL	9865	broad.mit.edu	37	7	28996325	28996325	+	RNA	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr7:28996325G>A	ENST00000322982.3	-	0	1609							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GCTCCTCCGCGAGACCTGCAG	0.721000													5	24					0	0	0.000602	0	0
GNL1	2794	broad.mit.edu	37	6	30522939	30522939	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr6:30522939C>T	ENST00000376621.3	-	3	1239	c.269G>A	c.(268-270)aGg>aAg	p.R90K		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	90					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity	p.R90K(1)		cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						TACCTCCTCCCTGCTGTCTCT	0.537000													45	198					0	0	0.002222	0	0
NASP	4678	broad.mit.edu	37	1	46083204	46083204	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:46083204G>A	ENST00000350030.3	+	14	2314	c.2227G>A	c.(2227-2229)Gga>Aga	p.G743R	NASP_ENST00000351223.3_Missense_Mutation_p.G404R|NASP_ENST00000530073.1_3'UTR|NASP_ENST00000372052.4_Missense_Mutation_p.G377R|NASP_ENST00000537798.1_Missense_Mutation_p.G679R|NASP_ENST00000402363.3_Missense_Mutation_p.G745R	NM_002482.3	NP_002473.2	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein (histone-binding)	743					blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding	p.G745R(1)		breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	17	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GGAGGTGAACGGAGGCAGTGG	0.493000													3	57					0	0	0.004672	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28212371	28212371	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr21:28212371G>A	ENST00000284984.2	-	6	2129	c.1675C>T	c.(1675-1677)Cat>Tat	p.H559Y		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	559	Disintegrin.|TSP type-1 1.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding	p.H559N(2)|p.H559Y(1)		central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		CAGCTTCCATGAAAAGGCGTC	0.463000													4	116					0	0	0.001168	0	0
SF1	7536	broad.mit.edu	37	11	64533557	64533557	+	Silent	SNP	G	G	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr11:64533557G>C	ENST00000377390.3	-	13	1990	c.1653C>G	c.(1651-1653)gcC>gcG	p.A551A	SF1_ENST00000334944.5_Silent_p.A551A|SF1_ENST00000433274.2_Silent_p.A525A|SF1_ENST00000377394.3_Intron|SF1_ENST00000227503.9_Intron|SF1_ENST00000422298.2_Intron|SF1_ENST00000377387.1_Intron	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	551	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding	p.A551A(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						GAGAAGCTGCGGCAGCCGCCT	0.682000													15	30					0	0	0.004990	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240794	39240794	+	Silent	SNP	C	C	A	rs9894106		TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr17:39240794C>A	ENST00000391417.4	+	1	336	c.336C>A	c.(334-336)ccC>ccA	p.P112P		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.R111_C115delRPSCC(1)|p.P112P(1)|p.?(1)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						gctgccgccccagctgctgcc	0.667000													3	9					0.004672	0.00604901	0.004672	1	0
WNT16	51384	broad.mit.edu	37	7	120969620	120969620	+	Splice_Site	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr7:120969620G>A	ENST00000222462.2	+	2	385		c.e2-1		WNT16_ENST00000361301.2_Splice_Site	NM_057168.1	NP_476509.1	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family, member 16						anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity	p.?(2)		breast(1)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)	18	all_neural(327;0.117)					GTGTCTTACAGGTGGTTGGGC	0.582000													12	94					0	0	0.003163	0	0
TRIML2	205860	broad.mit.edu	37	4	189012797	189012797	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr4:189012797G>A	ENST00000512729.1	-	7	1268	c.894C>T	c.(892-894)acC>acT	p.T298T	TRIML2_ENST00000326754.3_Silent_p.T323T	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	298	B30.2/SPRY.						ligase activity	p.T298T(1)		central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GAGTCCACTCGGTCCCCATCA	0.577000													35	166					0	0	0.003755	0	0
RASEF	158158	broad.mit.edu	37	9	85597694	85597694	+	Silent	SNP	T	T	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr9:85597694T>C	ENST00000376447.3	-	17	2381	c.2121A>G	c.(2119-2121)gaA>gaG	p.E707E		NM_152573.2	NP_689786.2	Q8IZ41	RASEF_HUMAN	RAS and EF-hand domain containing	707					protein transport|small GTPase mediated signal transduction	perinuclear region of cytoplasm	calcium ion binding|GTP binding	p.E707E(1)		NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(4)|liver(1)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	33						TCTTTTTCACTTCTCTgagac	0.418000													3	78					0	0	0.004672	0	0
ANKMY2	57037	broad.mit.edu	37	7	16640525	16640525	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr7:16640525G>A	ENST00000306999.2	-	10	1430	c.1187C>T	c.(1186-1188)cCa>cTa	p.P396L		NM_020319.2	NP_064715.1	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	396						cilium	zinc ion binding	p.P396L(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TTCAGCCTCTGGTTGCTCTTC	0.398000													4	68					0	0	0.000248	0	0
GPR174	84636	broad.mit.edu	37	X	78427197	78427197	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chrX:78427197G>A	ENST00000276077.1	+	1	729	c.693G>A	c.(691-693)atG>atA	p.M231I		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	231						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.M231I(1)		central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						CCTTGAAGATGATTCTAACCT	0.393000										HNSCC(63;0.18)			41	57					0	0	0.007835	0	0
OR51A7	119687	broad.mit.edu	37	11	4929375	4929375	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr11:4929375C>G	ENST00000359350.4	+	1	776	c.776C>G	c.(775-777)gCc>gGc	p.A259G	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004749.1	NP_001004749.1	Q8NH64	O51A7_HUMAN	olfactory receptor, family 51, subfamily A, member 7	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A259G(1)		breast(1)|endometrium(1)|large_intestine(7)|lung(13)|ovary(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACCCTGGCTGCCATGCATCAC	0.493000													79	221					0	0	0.003610	0	0
SLC46A2	57864	broad.mit.edu	37	9	115651960	115651960	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr9:115651960G>A	ENST00000374228.4	-	1	1233	c.1002C>T	c.(1000-1002)agC>agT	p.S334S		NM_033051.3	NP_149040.3	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	334						integral to membrane|plasma membrane	symporter activity	p.S334S(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|pancreas(1)|skin(1)	18						CACCCAGGAAGCTGGTGATGA	0.557000													42	19					0	0	0.002222	0	0
FAM90A1	55138	broad.mit.edu	37	12	8376143	8376143	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr12:8376143G>A	ENST00000538603.1	-	6	892	c.334C>T	c.(334-336)Ccg>Tcg	p.P112S	FAM90A1_ENST00000307435.6_Missense_Mutation_p.P112S	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	112							nucleic acid binding|zinc ion binding	p.P112S(1)		endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		TTCCTCTGCGGGTCTTGTGGC	0.547000													14	46					0	0	0.004990	0	0
HAO1	54363	broad.mit.edu	37	20	7866404	7866404	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr20:7866404G>A	ENST00000378789.3	-	6	972	c.921C>T	c.(919-921)ggC>ggT	p.G307G		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	307	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity	p.G307G(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CAGCCTTGGCGCCAAGAGCCA	0.483000													14	70					0	0	0.002450	0	0
RANBP17	64901	broad.mit.edu	37	5	170610377	170610377	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr5:170610377T>G	ENST00000523189.1	+	18	2145	c.1981T>G	c.(1981-1983)Ttc>Gtc	p.F661V	RANBP17_ENST00000521759.1_3'UTR	NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	661					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity	p.F661V(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCTCAGCGACTTCAGGTGTCG	0.403000			T	TRD@	ALL								29	70					0	0	0.008361	0	0
FAM46B	115572	broad.mit.edu	37	1	27332767	27332767	+	Silent	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:27332767G>A	ENST00000289166.5	-	2	1111	c.946C>T	c.(946-948)Ctg>Ttg	p.L316L		NM_052943.3	NP_443175.2	Q96A09	FA46B_HUMAN	family with sequence similarity 46, member B	316								p.L315L(1)		breast(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;7.71e-51)|OV - Ovarian serous cystadenocarcinoma(117;1.11e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|STAD - Stomach adenocarcinoma(196;0.00114)|READ - Rectum adenocarcinoma(331;0.0419)		TGCTCCACCAGGTCTGGAAAG	0.687000													3	32					0	0	0.004672	0	0
DNAH8	1769	broad.mit.edu	37	6	38840727	38840727	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr6:38840727G>A	ENST00000359357.3	+	49	6886	c.6632G>A	c.(6631-6633)tGg>tAg	p.W2211*	DNAH8_ENST00000449981.2_Nonsense_Mutation_p.W2428*|DNAH8_ENST00000441566.1_Nonsense_Mutation_p.W2175*					dynein, axonemal, heavy chain 8									p.W2211*(2)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GATGCCATCTGGATTGAGAAC	0.358000													35	77					0	0	0.002836	0	0
CPM	1368	broad.mit.edu	37	12	69260803	69260803	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr12:69260803G>C	ENST00000551568.1	-	7	873	c.813C>G	c.(811-813)atC>atG	p.I271M	CPM_ENST00000546373.1_Missense_Mutation_p.I271M|CPM_ENST00000338356.3_Missense_Mutation_p.I271M	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	271					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding	p.I271M(1)		large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			ACTGGGCCCAGATGTAGTTGT	0.408000													14	805					0	0	0.004007	0	0
DPY19L2	283417	broad.mit.edu	37	12	63963073	63963073	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr12:63963073C>A	ENST00000324472.4	-	21	2240	c.2057G>T	c.(2056-2058)aGa>aTa	p.R686I	DPY19L2_ENST00000413230.2_Missense_Mutation_p.R133I	NM_173812.4	NP_776173.3	Q6NUT2	D19L2_HUMAN	dpy-19-like 2 (C. elegans)	686					multicellular organismal development|spermatid development	integral to membrane		p.R686I(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(19)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	45			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		CAATTTATCTCTTACTTCTTT	0.289000													29	303					3.76114e-14	5.25704e-14	0.004289	1	0
USH2A	7399	broad.mit.edu	37	1	215963477	215963477	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr1:215963477T>A	ENST00000366943.2	-	51	10492	c.10106A>T	c.(10105-10107)aAa>aTa	p.K3369I	USH2A_ENST00000307340.3_Missense_Mutation_p.K3369I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3369					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.K3369I(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTACAGCATTTCTGGCTCTT	0.393000										HNSCC(13;0.011)			18	71					0	0	0.001882	0	0
NSUN2	54888	broad.mit.edu	37	5	6632745	6632745	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr5:6632745A>C	ENST00000264670.6	-	2	532	c.221T>G	c.(220-222)cTc>cGc	p.L74R	NSUN2_ENST00000506139.1_Missense_Mutation_p.L74R|NSUN2_ENST00000539938.1_5'UTR	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	74						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding	p.L74R(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						AGTGGCCGGGAGCGGCTCCCT	0.557000													4	133					0	0	0.000248	0	0
PRDM7	11105	broad.mit.edu	37	16	90128579	90128579	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr16:90128579A>G	ENST00000407825.1	-	7	651	c.14T>C	c.(13-15)tTc>tCc	p.F5S	PRDM7_ENST00000325921.6_Missense_Mutation_p.F5S|PRDM7_ENST00000449207.2_Missense_Mutation_p.F211S			Q9NQW5	PRDM7_HUMAN	PR domain containing 7	211						chromosome|nucleus	nucleic acid binding	p.F211S(1)|p.F5S(1)		lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		GTCAATGAAGAAGTTCTGACA	0.507000													13	38					0	0	0.003163	0	0
LINC00518	221718	broad.mit.edu	37	6	10430699	10430700	+	RNA	DEL	TT	TT	-	rs79230388		TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr6:10430699_10430700delTT	ENST00000496285.1	-	0	489					NR_027793.1																						CTCTGACTAGtttttttttttt	0.450													2	4	---	---	---	---					
MET	4233	broad.mit.edu	37	7	116412042	116412045	+	Splice_Site	DEL	AGGT	AGGT	-			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr7:116412042_116412045delAGGT	ENST00000397752.3	+	14	3227_3228	c.3028_splice	c.e14+1	p.E1009_splice	MET_ENST00000318493.6_Splice_Site_p.E1027_splice	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1009		Breakpoint for translocation to form TPR- MET oncogene.			axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.?(5)|p.982_1028del47(4)|p.L982_D1028del(3)|p.D981_D1028del(1)		NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CTTTTCCAGAAGGTATATTTCAGT	0.343			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				13	34	---	---	---	---					
FAM66D	100132923	broad.mit.edu	37	8	11994579	11994580	+	RNA	DEL	TG	TG	-			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr8:11994579_11994580delTG	ENST00000434078.2	+	0	608					NR_027425.1																						TGTTCgtgtttgtgtgtgtgtg	0.505													7	51	---	---	---	---					
XPOT	11260	broad.mit.edu	37	12	64812755	64812755	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr12:64812755delT	ENST00000332707.5	+	6	899	c.370delT	c.(370-372)ttfs	p.F126fs		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	126	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding	p.F126fs*6(1)		NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		GTGGCCCAAGTTTTTTTTTGA	0.443													7	478	---	---	---	---					
AE000661.37	0	broad.mit.edu	37	14	22933391	22933391	+	RNA	DEL	C	C	-	rs36090939		TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr14:22933391delC	ENST00000514473.2	-	0	225				TRDC_ENST00000390477.2_RNA|AE000661.37_ENST00000556777.1_RNA																							TTAGAAATGGCTAAGAAACCA	0.408													5	3	---	---	---	---					
SPAG9	9043	broad.mit.edu	37	17	49077041	49077041	+	Frame_Shift_Del	DEL	T	T	-			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr17:49077041delT	ENST00000262013.7	-	14	1853	c.1645delA	c.(1645-1647)ggfs	p.R549fs	SPAG9_ENST00000505279.1_Frame_Shift_Del_p.R535fs|SPAG9_ENST00000510283.1_Frame_Shift_Del_p.R392fs|SPAG9_ENST00000357122.4_Frame_Shift_Del_p.R535fs	NM_001130528.2	NP_001124000.1	O60271	JIP4_HUMAN	sperm associated antigen 9	549					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm		p.R535fs*28(1)		NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			ATGCTTGACCTTTTTTTTTCC	0.323													7	80	---	---	---	---					
CTC-513N18.6	0	broad.mit.edu	37	19	20634038	20634039	+	RNA	DEL	TG	TG	-			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr19:20634038_20634039delTG	ENST00000598131.1	+	0	160																											TTAGTAAAAATGTGTGTGTGTG	0.401													13	126	---	---	---	---					
CEP89	84902	broad.mit.edu	37	19	33406382	33406382	+	Frame_Shift_Del	DEL	T	T	-	rs145281633		TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr19:33406382delT	ENST00000305768.4	-	14	1514	c.1426delA	c.(1426-1428)ccfs	p.T476fs		NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	476						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						TGGCCGTGGGTTTTTGCCTCC	0.443													7	424	---	---	---	---					
WDR62	284403	broad.mit.edu	37	19	36583666	36583668	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr19:36583666_36583668delGCA	ENST00000401500.2	+	19	2321_2323	c.2286_2288delGCA	c.(2284-2289)cgg>cg	p.RQ762del	WDR62_ENST00000270301.7_In_Frame_Del_p.RQ762del	NM_001083961.1|NM_173636.4	NP_001077430.1|NP_775907.4	O43379	WDR62_HUMAN	WD repeat domain 62	762					cerebral cortex development	nucleus				cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(15)|prostate(4)|stomach(2)|urinary_tract(3)	43	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TTGACCACCGGCAGCAGCAGCAG	0.616													9	647	---	---	---	---					
LYPD3	27076	broad.mit.edu	37	19	43969653	43969655	+	In_Frame_Del	DEL	AGC	AGC	-	rs141441894	byFrequency	TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr19:43969653_43969655delAGC	ENST00000244333.3	-	1	157_159	c.69_71delGCT	c.(67-72)ctt>ct	p.LL23del		NM_014400.2	NP_055215.2	O95274	LYPD3_HUMAN	LY6/PLAUR domain containing 3	23						anchored to plasma membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|pancreas(1)|upper_aerodigestive_tract(2)	11		Prostate(69;0.0153)				ACCTCCGCGAAGCAGCAGCAGCA	0.675													9	244	---	---	---	---					
AC008103.5	0	broad.mit.edu	37	22	18842473	18842473	+	RNA	DEL	G	G	-	rs66618606		TCGA-50-6597-01A-11D-1855-08	TCGA-50-6597-10A-01D-1855-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cd0aeed5-93a1-4287-8a88-fe6b7b5e3983	32788069-6806-4112-afe3-28e731a6d8db	g.chr22:18842473delG	ENST00000412938.1	+	0	2208																											AGCTGCTGGTGGGGAGGTCTT	0.647													4	8	---	---	---	---					
