Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													6	42					0	0	0.00116845	0	0
PTCHD1	139411	broad.mit.edu	37	X	23412156	23412156	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chrX:23412156A>G	ENST00000379361.4	+	3	3381	c.2521A>G	c.(2521-2523)Att>Gtt	p.I841V		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	841					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						CTGCTTTGCCATTTTACCTGT	0.418000													35	76					0	0	0.000491102	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668708	176668708	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:176668708C>A	ENST00000367662.3	+	8	4383	c.3219C>A	c.(3217-3219)caC>caA	p.H1073Q		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1073					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CACATTCTCACAGGAAGTTCA	0.542000													14	193					2.31682e-05	0.000131075	0.000308642	1	0
ANKRD7	56311	broad.mit.edu	37	7	117876904	117876904	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr7:117876904G>C	ENST00000357099.4	+	6	869	c.696G>C	c.(694-696)caG>caC	p.Q232H	ANKRD7_ENST00000477532.1_3'UTR|ANKRD7_ENST00000433239.1_Missense_Mutation_p.Q159H|ANKRD7_ENST00000417525.1_Missense_Mutation_p.Q159H|ANKRD7_ENST00000265224.4_Missense_Mutation_p.Q212H			Q92527	ANKR7_HUMAN	ankyrin repeat domain 7	212					male gonad development			p.Q232H(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)	29						TTCTTCTTCAGCAAGGTGTGG	0.393000													4	112					0	0	0.00116845	0	0
PHLDB2	90102	broad.mit.edu	37	3	111685542	111685542	+	Nonsense_Mutation	SNP	G	G	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:111685542G>T	ENST00000431670.2	+	14	3571	c.3160G>T	c.(3160-3162)Gaa>Taa	p.E1054*	PHLDB2_ENST00000412622.1_Nonsense_Mutation_p.E1011*|PHLDB2_ENST00000393923.3_Nonsense_Mutation_p.E1038*|PHLDB2_ENST00000393925.3_Nonsense_Mutation_p.E1054*|PHLDB2_ENST00000470699.2_3'UTR|PHLDB2_ENST00000495180.1_Nonsense_Mutation_p.E545*|PHLDB2_ENST00000481953.1_Nonsense_Mutation_p.E1011*	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	1054						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GCGGCTGCTCGAATCCAGGGT	0.488000													14	29					1.05317e-09	6.39646e-09	0.000219431	1	0
PDE10A	10846	broad.mit.edu	37	6	165848820	165848820	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr6:165848820G>A	ENST00000366882.1	-	7	566	c.412C>T	c.(412-414)Cgc>Tgc	p.R138C	PDE10A_ENST00000354448.4_Missense_Mutation_p.R138C|PDE10A_ENST00000539869.2_Missense_Mutation_p.R148C			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	138	GAF 1.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	GGGATGAGGCGGGGTTTTCCT	0.488000													11	55					0	0	0.00185496	0	0
RHPN2	85415	broad.mit.edu	37	19	33512539	33512539	+	Missense_Mutation	SNP	T	T	C	rs143681913	by1000genomes	TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr19:33512539T>C	ENST00000254260.3	-	4	363	c.328A>G	c.(328-330)Att>Gtt	p.I110V	RHPN2_ENST00000400226.4_Intron	NM_033103.4	NP_149094.3	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	110					signal transduction	perinuclear region of cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(5)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(3)|urinary_tract(1)	44	Esophageal squamous(110;0.137)					ATCAGGGGAATCGTAAATGCC	0.532000													3	63					0	0	0.00024832	0	0
TRIM41	90933	broad.mit.edu	37	5	180651713	180651713	+	Silent	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:180651713C>T	ENST00000315073.5	+	1	1424	c.714C>T	c.(712-714)tgC>tgT	p.C238C	TRIM41_ENST00000351937.5_Silent_p.C238C|CTC-338M12.7_ENST00000499096.2_RNA	NM_033549.4	NP_291027.3	Q8WV44	TRI41_HUMAN	tripartite motif containing 41	238						cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(3)|prostate(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	26	all_cancers(89;9.17e-06)|all_epithelial(37;1.19e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCTCTTCTGCGAGGTAGACG	0.592000													22	43					0	0	0.00188189	0	0
ST7L	54879	broad.mit.edu	37	1	113124662	113124662	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:113124662C>G	ENST00000358039.4	-	9	1325	c.1021G>C	c.(1021-1023)Gaa>Caa	p.E341Q	ST7L_ENST00000343210.7_Missense_Mutation_p.E341Q|ST7L_ENST00000360743.4_Missense_Mutation_p.E341Q|ST7L_ENST00000490067.1_Missense_Mutation_p.E324Q|ST7L_ENST00000538187.1_Missense_Mutation_p.E285Q|ST7L_ENST00000544629.1_Missense_Mutation_p.E276Q|ST7L_ENST00000463235.1_5'UTR|ST7L_ENST00000543570.1_Missense_Mutation_p.E324Q|ST7L_ENST00000369666.1_Missense_Mutation_p.E324Q|ST7L_ENST00000369668.2_Missense_Mutation_p.E341Q|ST7L_ENST00000369669.1_Missense_Mutation_p.E158Q	NM_017744.4|NM_138727.3	NP_060214.2|NP_620055.1	Q8TDW4	ST7L_HUMAN	suppression of tumorigenicity 7 like	341					negative regulation of cell growth	integral to membrane	binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(1)|prostate(2)|stomach(1)|urinary_tract(3)	15	Lung SC(450;0.246)	all_cancers(81;1.44e-07)|all_epithelial(167;7.64e-07)|all_lung(203;2.16e-05)|Lung NSC(69;3.86e-05)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCTGTAATTCTAAAAGTGAT	0.328000													3	62					0	0	0.00024832	0	0
TINAG	27283	broad.mit.edu	37	6	54214655	54214655	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr6:54214655G>T	ENST00000259782.4	+	7	1137	c.1041G>T	c.(1039-1041)agG>agT	p.R347S		NM_014464.3	NP_055279.3	Q9UJW2	TINAG_HUMAN	tubulointerstitial nephritis antigen	347					cell adhesion|immune response|Malpighian tubule morphogenesis|proteolysis	basement membrane	cysteine-type endopeptidase activity|nucleotide binding|polysaccharide binding|scavenger receptor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(1)	34	Lung NSC(77;0.0518)		LUSC - Lung squamous cell carcinoma(124;0.246)			AATCTAACAGGATCTATCAAT	0.433000													10	97					1.08611e-07	6.40804e-07	0.000978159	1	0
GGT5	2687	broad.mit.edu	37	22	24640618	24640618	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr22:24640618C>T	ENST00000327365.4	-	1	492	c.76G>A	c.(76-78)Gct>Act	p.A26T	GGT5_ENST00000263112.7_Missense_Mutation_p.A26T|GGT5_ENST00000418439.2_Missense_Mutation_p.A26T|GGT5_ENST00000398292.3_Missense_Mutation_p.A26T	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	26					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity	p.A26P(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						AGGACCACAGCCAGCACAATG	0.677000													15	35					0	0	0.000422831	0	0
CCNB3	85417	broad.mit.edu	37	X	50094701	50094701	+	Nonstop_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chrX:50094701A>G	ENST00000376042.1	+	13	4485	c.4187A>G	c.(4186-4188)tAg>tGg	p.*1396W	CCNB3_ENST00000276014.7_Nonstop_Mutation_p.*1396W|CCNB3_ENST00000376038.1_Nonstop_Mutation_p.*292W|CCNB3_ENST00000348603.2_Nonstop_Mutation_p.*292W			Q8WWL7	CCNB3_HUMAN	cyclin B3	0					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					CTGGTACTCTAGCAGCAGCCA	0.428000													5	48					0	0	0.000602214	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178541012	178541012	+	Silent	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:178541012G>A	ENST00000251582.7	-	22	3593	c.3492C>T	c.(3490-3492)ccC>ccT	p.P1164P		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	1164					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GGATTTTGTAGGGTTCATCTA	0.547000													30	103					0	0	0.00178596	0	0
N4BP2	55728	broad.mit.edu	37	4	40122226	40122226	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr4:40122226C>G	ENST00000261435.6	+	9	2911	c.2495C>G	c.(2494-2496)tCt>tGt	p.S832C		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	832						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						AACAGTGTATCTGTGAATACA	0.403000													4	31					0	0	0.00024832	0	0
GPR52	9293	broad.mit.edu	37	1	174418031	174418031	+	Missense_Mutation	SNP	G	G	A	rs144653948		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:174418031G>A	ENST00000367685.2	+	1	820	c.782G>A	c.(781-783)cGt>cAt	p.R261H	RABGAP1L_ENST00000357444.6_Intron|RABGAP1L_ENST00000367689.3_Intron|RABGAP1L_ENST00000251507.4_Intron	NM_005684.4	NP_005675.3	Q9Y2T5	GPR52_HUMAN	G protein-coupled receptor 52	261						integral to plasma membrane	G-protein coupled receptor activity			breast(3)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|prostate(1)|skin(2)	20						AGCCCTGACCGTCGCTACGCC	0.458000													30	74					0	0	0.001512	0	0
ZEB2	9839	broad.mit.edu	37	2	145147072	145147072	+	Silent	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:145147072C>T	ENST00000558170.2	-	10	4775	c.3591G>A	c.(3589-3591)ggG>ggA	p.G1197G	ZEB2_ENST00000303660.4_Silent_p.G1197G|ZEB2_ENST00000539609.3_Silent_p.G1173G|ZEB2_ENST00000409487.3_Silent_p.G1197G	NM_014795.3	NP_055610.1	O60315	ZEB2_HUMAN	zinc finger E-box binding homeobox 2	1197	Glu-rich (acidic).					cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(7)|kidney(6)|large_intestine(23)|lung(45)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	107				BRCA - Breast invasive adenocarcinoma(221;0.112)		TTTCCATTTTCCCATCCTCCG	0.388000													57	236					0	0	0.000781405	0	0
REEP2	51308	broad.mit.edu	37	5	137776766	137776766	+	Missense_Mutation	SNP	G	G	A	rs147103044		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:137776766G>A	ENST00000378339.2	+	2	286	c.94G>A	c.(94-96)Gtg>Atg	p.V32M	REEP2_ENST00000254901.5_Missense_Mutation_p.V32M|REEP2_ENST00000464751.2_3'UTR|REEP2_ENST00000506158.1_5'UTR	NM_001271803.1	NP_001258732.1	Q9BRK0	REEP2_HUMAN	receptor accessory protein 2	32						integral to membrane				endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	12			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			GACAAAAAACGTGAAGGAATA	0.547000													14	34					0	0	0.000308642	0	0
PPIG	9360	broad.mit.edu	37	2	170488419	170488419	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:170488419G>A	ENST00000260970.3	+	11	1125	c.905G>A	c.(904-906)aGa>aAa	p.R302K	PPIG_ENST00000462903.1_Missense_Mutation_p.R302K|PPIG_ENST00000448752.2_Missense_Mutation_p.R302K|PPIG_ENST00000482772.1_3'UTR|PPIG_ENST00000409714.3_Missense_Mutation_p.R287K	NM_004792.2	NP_004783.2	Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	302					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	aggaaaaacagagagagagaa	0.348000													5	19					0	0	0.000602214	0	0
ADIPOQ	9370	broad.mit.edu	37	3	186570990	186570990	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:186570990G>A	ENST00000412955.2	+	2	284	c.143G>A	c.(142-144)gGc>gAc	p.G48D	ADIPOQ-AS1_ENST00000422718.1_RNA|ADIPOQ_ENST00000320741.2_Missense_Mutation_p.G48D|ADIPOQ_ENST00000444204.2_Missense_Mutation_p.G48D			Q15848	ADIPO_HUMAN	adiponectin, C1Q and collagen domain containing	48	Collagen-like.				brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(2)	16	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GGGCATCCGGGCCATAATGGG	0.612000													8	15					0	0	0.000157383	0	0
ZNF644	84146	broad.mit.edu	37	1	91403507	91403507	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:91403507G>T	ENST00000370440.1	-	4	3440	c.3223C>A	c.(3223-3225)Cca>Aca	p.P1075T	ZNF644_ENST00000347275.5_Intron|ZNF644_ENST00000467231.1_Intron|ZNF644_ENST00000337393.5_Missense_Mutation_p.P1075T|ZNF644_ENST00000361321.5_Intron			Q9H582	ZN644_HUMAN	zinc finger protein 644	1075					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(2)|large_intestine(10)|lung(21)|ovary(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	47		all_lung(203;0.00206)|Lung NSC(277;0.0519)|Lung SC(238;0.101)		all cancers(265;0.00102)|Epithelial(280;0.00766)|KIRC - Kidney renal clear cell carcinoma(1967;0.147)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		ACACAGATTGGAGATTTGTGA	0.368000													6	103					2.7689e-08	1.65732e-07	8.12818e-05	1	0
MUC4	4585	broad.mit.edu	37	3	195538661	195538661	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:195538661G>A	ENST00000463781.3	-	1	487	c.28C>T	c.(28-30)Ccc>Tcc	p.P10S	MUC4_ENST00000475231.1_Missense_Mutation_p.P10S|MUC4_ENST00000478685.1_5'UTR|MUC4_ENST00000349607.4_Missense_Mutation_p.P10S|MUC4_ENST00000346145.4_Missense_Mutation_p.P10S	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	10					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACACCCAGGGGACCCTCCTC	0.652000													13	48					0	0	0.000566183	0	0
IL1RL1	9173	broad.mit.edu	37	2	102955462	102955462	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:102955462C>A	ENST00000311734.2	+	3	566	c.227C>A	c.(226-228)cCa>cAa	p.P76Q	IL1RL1_ENST00000473175.1_3'UTR|IL1RL1_ENST00000233954.1_Missense_Mutation_p.P76Q|IL1RL1_ENST00000409584.1_Missense_Mutation_p.P76Q|IL1RL1_ENST00000393393.3_Missense_Mutation_p.P76Q|IL1RL1_ENST00000404917.2_5'UTR			Q01638	ILRL1_HUMAN	interleukin 1 receptor-like 1	76	Ig-like C2-type 1.				innate immune response	integral to membrane	interleukin-1 receptor activity|receptor signaling protein activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(3)|urinary_tract(1)	16						AAGTTTCTACCAGCTGCAGTT	0.433000													19	138					0.000229342	0.00124629	0.00188189	1	0
TP53	7157	broad.mit.edu	37	17	7574018	7574018	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr17:7574018G>A	ENST00000269305.4	-	10	1198	c.1009C>T	c.(1009-1011)Cgc>Tgc	p.R337C	TP53_ENST00000455263.2_3'UTR|TP53_ENST00000445888.2_Missense_Mutation_p.R337C|TP53_ENST00000359597.4_Intron|TP53_ENST00000420246.2_3'UTR|TP53_ENST00000413465.2_Intron	NM_000546.5|NM_001126112.2|NM_001126118.1|NM_001276760.1|NM_001276761.1	NP_000537.3|NP_001119584.1|NP_001119590.1|NP_001263689.1|NP_001263690.1	P04637	P53_HUMAN	tumor protein p53	337	Interaction with CARM1.|Interaction with HIPK1 (By similarity).|Interaction with HIPK2.|Oligomerization.		R -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> H (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R337C(18)|p.0?(8)|p.R337fs*8(2)|p.R337G(1)|p.?(1)|p.I332fs*5(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTCGAAGCGCTCACGCCCA	0.522000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			26	29					0	0	0.001512	0	0
CRB1	23418	broad.mit.edu	37	1	197316538	197316538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:197316538G>A	ENST00000367400.3	+	4	1052	c.917G>A	c.(916-918)tGg>tAg	p.W306*	CRB1_ENST00000535699.1_Nonsense_Mutation_p.W237*|CRB1_ENST00000543483.1_Nonsense_Mutation_p.W5*|CRB1_ENST00000367399.2_Intron|CRB1_ENST00000538660.1_Nonsense_Mutation_p.W306*	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	306	EGF-like 8.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CCTCTTTGTTGGTCAAAACCT	0.423000													23	61					0	0	0.000375601	0	0
COL6A2	1292	broad.mit.edu	37	21	47549151	47549151	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr21:47549151C>T	ENST00000357838.4	+	28	2585	c.2503C>T	c.(2503-2505)Cgc>Tgc	p.R835C	COL6A2_ENST00000310645.5_3'UTR|COL6A2_ENST00000409416.1_3'UTR|COL6A2_ENST00000300527.4_Intron|COL6A2_ENST00000397763.1_Missense_Mutation_p.R835C	NM_058174.2	NP_478054.2	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	572	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CACCTTCCTCCGCACGGAAGA	0.672000													31	146					0	0	0.001512	0	0
SORCS1	114815	broad.mit.edu	37	10	108336983	108336983	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr10:108336983A>G	ENST00000344440.6	-	27	3592	c.3593T>C	c.(3592-3594)gTt>gCt	p.V1198A	SORCS1_ENST00000263054.6_3'UTR|SORCS1_ENST00000369698.1_3'UTR	NM_001013031.2|NM_001206569.1|NM_001206571.1|NM_001206572.1	NP_001013049.1|NP_001193498.1|NP_001193500.1|NP_001193501.1	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	0						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CTCCATTCAAACATTTACATA	0.308000													21	52					0	0	0.00188189	0	0
CPD	1362	broad.mit.edu	37	17	28782439	28782439	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr17:28782439T>G	ENST00000225719.4	+	15	3364	c.3288T>G	c.(3286-3288)gaT>gaG	p.D1096E	CPD_ENST00000584051.1_3'UTR|CPD_ENST00000543464.2_Missense_Mutation_p.D849E	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	1096	Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						TTGCCTTAGATGGTGGTTCCA	0.363000													16	227					0	0	0.000308642	0	0
WDR13	64743	broad.mit.edu	37	X	48460281	48460281	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chrX:48460281C>A	ENST00000218056.5	+	6	1446	c.941C>A	c.(940-942)gCc>gAc	p.A314D		NM_001166426.1|NM_017883.4	NP_001159898.1|NP_060353.2	Q9H1Z4	WDR13_HUMAN	WD repeat domain 13	314						cytoplasm|nucleus				endometrium(1)|large_intestine(4)|lung(4)|ovary(2)	11						TCCTTTGATGCCCCTGGCCGG	0.577000													11	37					5.50884e-06	3.15993e-05	0.00136819	1	0
GBF1	8729	broad.mit.edu	37	10	104112253	104112253	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr10:104112253A>G	ENST00000369983.3	+	7	822	c.562A>G	c.(562-564)Atg>Gtg	p.M188V		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	188					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		TCTCGTAGACATGGTGCAGCT	0.507000											OREG0020477	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	56					0	0	0.00185496	0	0
VPS16	64601	broad.mit.edu	37	20	2845910	2845910	+	Silent	SNP	T	T	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr20:2845910T>G	ENST00000380445.3	+	21	2193	c.2121T>G	c.(2119-2121)ggT>ggG	p.G707G	VPS16_ENST00000380469.3_Silent_p.G563G|PTPRA_ENST00000380393.3_5'UTR|VPS16_ENST00000380443.3_Silent_p.G393G	NM_022575.2	NP_072097.2	Q9H269	VPS16_HUMAN	vacuolar protein sorting 16 homolog (S. cerevisiae)	707					intracellular protein transport	early endosome|HOPS complex|late endosome membrane|lysosomal membrane|recycling endosome				NS(3)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	37						TTCTTGGCGGTCACAACAAGC	0.617000													17	43					0	0	0.000958276	0	0
OR52N1	79473	broad.mit.edu	37	11	5809217	5809217	+	Missense_Mutation	SNP	A	A	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr11:5809217A>T	ENST00000317078.1	-	1	829	c.830T>A	c.(829-831)aTt>aAt	p.I277N	TRIM5_ENST00000380027.1_Intron	NM_001001913.1	NP_001001913.1	Q8NH53	O52N1_HUMAN	olfactory receptor, family 52, subfamily N, member 1	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(15)|prostate(2)|skin(3)	31		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		AGCCATAATAATATGTATGTG	0.438000													12	52					0	0	0.00185496	0	0
GPR180	160897	broad.mit.edu	37	13	95271525	95271525	+	Silent	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr13:95271525G>C	ENST00000376958.4	+	4	652	c.627G>C	c.(625-627)ctG>ctC	p.L209L		NM_180989.5	NP_851320.1	Q86V85	GP180_HUMAN	G protein-coupled receptor 180	209						integral to membrane				breast(1)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	10	all_neural(89;0.0684)|Medulloblastoma(90;0.163)					TAAAGGTTCTGACAACTGCAT	0.388000													3	75					0	0	6.4e-05	0	0
NIPAL3	57185	broad.mit.edu	37	1	24786997	24786997	+	Missense_Mutation	SNP	G	G	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:24786997G>T	ENST00000003912.3	+	11	1358	c.643G>T	c.(643-645)Ggg>Tgg	p.G215W	NIPAL3_ENST00000374399.4_Missense_Mutation_p.G297W|NIPAL3_ENST00000339255.2_Missense_Mutation_p.G297W			Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	297						integral to membrane				endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(1)	14						GGACTTCATCGGGGAGGACGT	0.493000													4	54					8.12818e-05	0.000447592	8.12818e-05	1	0
MUC4	4585	broad.mit.edu	37	3	195538662	195538662	+	Silent	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:195538662G>C	ENST00000463781.3	-	1	486	c.27C>G	c.(25-27)gtC>gtG	p.V9V	MUC4_ENST00000475231.1_Silent_p.V9V|MUC4_ENST00000478685.1_5'UTR|MUC4_ENST00000349607.4_Silent_p.V9V|MUC4_ENST00000346145.4_Silent_p.V9V	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	9					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		ACACCCAGGGGACCCTCCTCC	0.647000													13	49					0	0	0.000566183	0	0
TTN	7273	broad.mit.edu	37	2	179447908	179447908	+	Silent	SNP	A	A	C	rs55766906		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:179447908A>C	ENST00000589042.1	-	313	65846	c.65622T>G	c.(65620-65622)acT>acG	p.T21874T	TTN_ENST00000342992.6_Silent_p.T19306T|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000342175.6_Silent_p.T13001T|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Silent_p.T12809T|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000591111.1_Silent_p.T20233T|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000359218.5_Silent_p.T12934T	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20233	Fibronectin type-III 58.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGCTTTCACAGTAAGCAAAG	0.398000													6	21					0	0	0.000157383	0	0
KIF20A	10112	broad.mit.edu	37	5	137521298	137521298	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:137521298G>A	ENST00000394894.3	+	16	2250	c.2024G>A	c.(2023-2025)cGg>cAg	p.R675Q	KIF20A_ENST00000508792.1_Missense_Mutation_p.R657Q	NM_005733.2	NP_005724.1	O95235	KI20A_HUMAN	kinesin family member 20A	675					cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|liver(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(1)	27			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTGGCCCTACGGCGGTCACAA	0.507000													13	118					0	0	0.000219431	0	0
FOXG1	2290	broad.mit.edu	37	14	29237174	29237174	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr14:29237174G>A	ENST00000382535.3	+	2	1058	c.689G>A	c.(688-690)cGc>cAc	p.R230H	FOXG1_ENST00000313071.4_Missense_Mutation_p.R230H			P55316	FOXG1_HUMAN	forkhead box G1	230					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.R230H(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		AACTCCATCCGCCACAATCTG	0.592000													16	30					0	0	0.000566183	0	0
FGF10	2255	broad.mit.edu	37	5	44388506	44388506	+	Missense_Mutation	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:44388506C>G	ENST00000264664.4	-	1	393	c.279G>C	c.(277-279)gaG>gaC	p.E93D		NM_004465.1	NP_004456.1	O15520	FGF10_HUMAN	fibroblast growth factor 10	93					actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			haematopoietic_and_lymphoid_tissue(1)|lung(11)|skin(1)	13	Lung NSC(6;1.12e-06)					TCCCGTTCTTCTCAATCTTGA	0.517000													26	62					0	0	0.000409698	0	0
IGHV1-8	28472	broad.mit.edu	37	14	106539276	106539276	+	RNA	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr14:106539276C>G	ENST00000390599.2	-	0	215																											CAGTTGATATCATAACTGGTG	0.557000													25	138					0	0	0.00047179	0	0
NUP107	57122	broad.mit.edu	37	12	69107517	69107517	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr12:69107517A>G	ENST00000229179.4	+	11	1230	c.898A>G	c.(898-900)Act>Gct	p.T300A	NUP107_ENST00000539906.1_Missense_Mutation_p.T271A|NUP107_ENST00000378905.2_Missense_Mutation_p.T149A	NM_020401.2	NP_065134.1	P57740	NU107_HUMAN	nucleoporin 107kDa	300					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			CAGGGAAAATACTCTGCATAC	0.328000													14	45					0	0	0.000219431	0	0
ARAP1	116985	broad.mit.edu	37	11	72408407	72408407	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr11:72408407C>T	ENST00000359373.5	-	21	3765	c.2914G>A	c.(2914-2916)Gtg>Atg	p.V972M	ARAP1_ENST00000426523.1_Missense_Mutation_p.V727M|ARAP1_ENST00000429686.1_Missense_Mutation_p.V666M|ARAP1_ENST00000495878.1_5'UTR|ARAP1_ENST00000393605.3_Missense_Mutation_p.V732M|ARAP1_ENST00000455638.2_Missense_Mutation_p.V972M|ARAP1_ENST00000393609.3_Missense_Mutation_p.V972M|ARAP1_ENST00000334211.8_Missense_Mutation_p.V727M			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	972	Rho-GAP.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						TACACGATCACCGGGATATCC	0.682000													4	14					0	0	0.000602214	0	0
CANX	821	broad.mit.edu	37	5	179151752	179151752	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:179151752G>A	ENST00000247461.4	+	13	1813	c.1613G>A	c.(1612-1614)gGa>gAa	p.G538E	CANX_ENST00000504734.1_Missense_Mutation_p.G538E|CANX_ENST00000415618.2_Missense_Mutation_p.G573E|CANX_ENST00000452673.2_Missense_Mutation_p.G538E|CANX_ENST00000512607.2_Missense_Mutation_p.G430E	NM_001746.3	NP_001737.1	P27824	CALX_HUMAN	calnexin	538					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|prostate(2)|urinary_tract(3)	22	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	aaggacaagggagatgaggag	0.433000													7	7					0	0	8.12818e-05	0	0
TM4SF1	4071	broad.mit.edu	37	3	149093484	149093484	+	Missense_Mutation	SNP	A	A	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr3:149093484A>C	ENST00000305366.3	-	2	567	c.250T>G	c.(250-252)Tgt>Ggt	p.C84G	TM4SF1_ENST00000472441.1_5'UTR	NM_014220.2	NP_055035.1	P30408	T4S1_HUMAN	transmembrane 4 L six family member 1	84						integral to plasma membrane				endometrium(3)|large_intestine(1)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CGTTTGCCACAGTTTTCATGG	0.517000													18	157					0	0	0.00152264	0	0
ATP2B4	493	broad.mit.edu	37	1	203668679	203668679	+	Silent	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:203668679C>T	ENST00000357681.5	+	4	1606	c.483C>T	c.(481-483)atC>atT	p.I161I	ATP2B4_ENST00000391954.2_Silent_p.I161I|ATP2B4_ENST00000367218.3_Silent_p.I161I|ATP2B4_ENST00000341360.2_Silent_p.I161I|ATP2B4_ENST00000367219.3_Silent_p.I161I	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	161					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			CAGTGATCATCGTGGTGTTAG	0.502000													11	193					0	0	0.00136819	0	0
HSD17B3	3293	broad.mit.edu	37	9	98997839	98997839	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr9:98997839C>T	ENST00000375263.3	-	11	883	c.836G>A	c.(835-837)aGc>aAc	p.S279N	HSD17B3_ENST00000375262.2_Missense_Mutation_p.S229N|HSD17B3_ENST00000464104.1_5'UTR	NM_000197.1	NP_000188.1	P37058	DHB3_HUMAN	hydroxysteroid (17-beta) dehydrogenase 3	279					androgen biosynthetic process|male genitalia development	endoplasmic reticulum membrane|microsome	binding|testosterone 17-beta-dehydrogenase (NAD+) activity|testosterone 17-beta-dehydrogenase (NADP+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13		Acute lymphoblastic leukemia(62;0.0171)|all_hematologic(171;0.214)			NADH(DB00157)	CGGGATCAGGCTCAGAAAGCC	0.488000													11	10					0	0	0.000978159	0	0
MYO18A	399687	broad.mit.edu	37	17	27493549	27493549	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr17:27493549T>C	ENST00000527372.1	-	2	590	c.410A>G	c.(409-411)aAg>aGg	p.K137R	MYO18A_ENST00000354329.4_Missense_Mutation_p.K137R|MYO18A_ENST00000533112.1_Missense_Mutation_p.K137R|MYO18A_ENST00000531253.1_Missense_Mutation_p.K137R	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	137					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GGAAAAGCGCTTGACAATCAT	0.622000													8	64					0	0	0.000274275	0	0
DHX37	57647	broad.mit.edu	37	12	125434579	125434579	+	Silent	SNP	C	C	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr12:125434579C>G	ENST00000308736.2	-	25	3341	c.3243G>C	c.(3241-3243)cgG>cgC	p.R1081R	DHX37_ENST00000544745.1_Silent_p.R868R	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	1081			R -> Q (in dbSNP:rs4447263).				ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		GCAGACAGCTCCGGTATGAGG	0.662000													8	15					0	0	0.000157383	0	0
SHCBP1	79801	broad.mit.edu	37	16	46615942	46615942	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr16:46615942G>C	ENST00000303383.3	-	13	1984	c.1718C>G	c.(1717-1719)aCa>aGa	p.T573R		NM_024745.4	NP_079021.3	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	573										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				CTCTCCACTTGTCTGAATTTT	0.373000													17	88					0	0	0.00121646	0	0
CYP4F11	57834	broad.mit.edu	37	19	16035624	16035624	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr19:16035624C>A	ENST00000326742.7	-	5	595	c.594G>T	c.(592-594)atG>atT	p.M198I	CYP4F11_ENST00000402119.3_Missense_Mutation_p.M198I|CYP4F11_ENST00000248041.7_Missense_Mutation_p.M198I			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	198					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						TGTCCAAGGTCATGAGGCTGA	0.537000													21	81					9.95505e-16	6.13647e-15	0.000295444	1	0
CAMTA1	23261	broad.mit.edu	37	1	7700570	7700570	+	Silent	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:7700570G>A	ENST00000303635.7	+	7	828	c.621G>A	c.(619-621)gcG>gcA	p.A207A	CAMTA1_ENST00000439411.2_Silent_p.A207A	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	207					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGGAGTGGGCGAAATGGACGA	0.627000			T	WWTR1	epitheliod hemangioendothelioma								27	73					0	0	0.001512	0	0
PPIG	9360	broad.mit.edu	37	2	170489767	170489767	+	Missense_Mutation	SNP	T	T	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr2:170489767T>A	ENST00000462903.1	+	12	1207	c.1027T>A	c.(1027-1029)Tct>Act	p.S343T	PPIG_ENST00000448752.2_Intron|PPIG_ENST00000482772.1_Intron|PPIG_ENST00000260970.3_Intron|PPIG_ENST00000409714.3_Intron			Q13427	PPIG_HUMAN	peptidylprolyl isomerase G (cyclophilin G)	0					protein folding|RNA splicing	nuclear matrix|nuclear speck	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(17)|ovary(2)|stomach(1)|urinary_tract(1)	43					L-Proline(DB00172)	GGTAGGTGATTCTTTCCCCAG	0.358000													9	45					0	0	0.000442599	0	0
OR10J3	441911	broad.mit.edu	37	1	159283480	159283480	+	Missense_Mutation	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:159283480C>T	ENST00000332217.5	-	1	969	c.970G>A	c.(970-972)Gcg>Acg	p.A324T		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	324					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					TTTATAAACGCAAAGGAAAAG	0.393000													15	65					0	0	0.000308642	0	0
UTRN	7402	broad.mit.edu	37	6	144875916	144875916	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr6:144875916T>C	ENST00000367545.3	+	48	7021	c.7021T>C	c.(7021-7023)Tgg>Cgg	p.W2341R		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2341					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		CAGTCTTCAGTGGGATGACCA	0.493000													4	67					0	0	0.00024832	0	0
CDH7	1005	broad.mit.edu	37	18	63526954	63526954	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr18:63526954A>G	ENST00000536984.2	+	10	2199	c.1505A>G	c.(1504-1506)aAa>aGa	p.K502R	CDH7_ENST00000323011.3_Missense_Mutation_p.K502R|CDH7_ENST00000397968.2_Missense_Mutation_p.K502R			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	502	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GTTATCCAGAAAATCAGTGCT	0.363000													6	23					0	0	0.00116845	0	0
FAM155B	27112	broad.mit.edu	37	X	68725635	68725635	+	Missense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chrX:68725635C>A	ENST00000252338.4	+	1	552	c.510C>A	c.(508-510)gaC>gaA	p.D170E		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	170						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						GGCCCCCTGACTCCCTTTCCC	0.592000													11	34					6.40141e-05	0.000357268	0.000978159	1	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr17:39296167A>G	ENST00000345847.4	-	1	572	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													3	11					0	0	6.4e-05	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237249	140237249	+	Missense_Mutation	SNP	G	G	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:140237249G>C	ENST00000307360.5	+	1	1616	c.1616G>C	c.(1615-1617)gGg>gCg	p.G539A	PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1												p.G539A(2)		NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGATGGGGGCGTGCCG	0.687000													5	148					0	0	0.000602214	0	0
CHEK2	11200	broad.mit.edu	37	22	29091782	29091782	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr22:29091782G>A	ENST00000544772.1	-	12	1948	c.512C>T	c.(511-513)gCg>gTg	p.A171V	CHEK2_ENST00000328354.6_Missense_Mutation_p.A392V|CHEK2_ENST00000382578.1_Missense_Mutation_p.A301V|CHEK2_ENST00000404276.1_Missense_Mutation_p.A392V|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000403642.1_Missense_Mutation_p.A301V|CHEK2_ENST00000382580.2_Missense_Mutation_p.A435V|CHEK2_ENST00000348295.3_Missense_Mutation_p.A363V|CHEK2_ENST00000405598.1_Missense_Mutation_p.A392V|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000402731.1_Missense_Mutation_p.A363V	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	392	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						AACTTCAGGCGCCAAGTAGGT	0.428000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					15	55					0	0	0.000958276	0	0
ZBTB37	84614	broad.mit.edu	37	1	173842711	173842711	+	Missense_Mutation	SNP	A	A	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:173842711A>G	ENST00000432989.1	+	4	1303	c.1030A>G	c.(1030-1032)Agt>Ggt	p.S344G	ZBTB37_ENST00000367702.1_Missense_Mutation_p.S344G|ZBTB37_ENST00000367704.1_Intron|ZBTB37_ENST00000427304.1_Intron|ZBTB37_ENST00000367701.4_Intron	NM_032522.3	NP_115911.1	Q5TC79	ZBT37_HUMAN	zinc finger and BTB domain containing 37	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(4)	13						CCAGGTATGGAGTTGTGGATT	0.473000													8	29					0	0	0.000442599	0	0
FCHSD1	89848	broad.mit.edu	37	5	141030648	141030648	+	Nonsense_Mutation	SNP	C	C	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:141030648C>A	ENST00000435817.2	-	2	108	c.58G>T	c.(58-60)Gaa>Taa	p.E20*	FCHSD1_ENST00000522126.1_5'UTR|FCHSD1_ENST00000522783.1_Nonsense_Mutation_p.E20*|FCHSD1_ENST00000519800.1_Nonsense_Mutation_p.E20*	NM_033449.2	NP_258260.1	Q86WN1	FCSD1_HUMAN	FCH and double SH3 domains 1	20	FCH.								FCHSD1/BRAF(2)	central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCAGCTGTTCCAGGAAGCGA	0.587000													5	6					0.00116845	0.00626712	0.00116845	1	0
ANKRD34A	284615	broad.mit.edu	37	1	145474307	145474307	+	Missense_Mutation	SNP	T	T	G			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr1:145474307T>G	ENST00000323397.4	+	4	2272	c.979T>G	c.(979-981)Tca>Gca	p.S327A		NM_001039888.2	NP_001034977.1	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34A	327	Pro-rich.									endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	20	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGGTCCCCCTTCAGGGCTGAG	0.647000													14	24					0	0	0.000308642	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62820921	62820921	+	RNA	SNP	C	C	T			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr17:62820921C>T	ENST00000582986.1	-	0	188					NR_024386.1																						TCACTAGTGACCACCATGTCC	0.562000													8	48					0	0	0.000157383	0	0
RPAP1	26015	broad.mit.edu	37	15	41813100	41813100	+	Missense_Mutation	SNP	G	G	A	rs138581766		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr15:41813100G>A	ENST00000304330.4	-	22	3400	c.3284C>T	c.(3283-3285)cCg>cTg	p.P1095L	RPAP1_ENST00000561603.1_Intron	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	1095	Leu-rich.					nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGGCAGCAGCGGCTCCGTAGG	0.662000													7	54					0	0	8.12818e-05	0	0
SORCS1	114815	broad.mit.edu	37	10	108337011	108337011	+	Missense_Mutation	SNP	T	T	C			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr10:108337011T>C	ENST00000344440.6	-	27	3564	c.3565A>G	c.(3565-3567)Aca>Gca	p.T1189A	SORCS1_ENST00000263054.6_3'UTR|SORCS1_ENST00000369698.1_3'UTR	NM_001013031.2|NM_001206569.1|NM_001206571.1|NM_001206572.1	NP_001013049.1|NP_001193498.1|NP_001193500.1|NP_001193501.1	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	0						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATTTCTTTTGTGCTTTGATTC	0.313000													23	57					0	0	0.000720815	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65208417	65208417	+	Missense_Mutation	SNP	G	G	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr14:65208417G>A	ENST00000247226.7	+	14	2322	c.2014G>A	c.(2014-2016)Gaa>Aaa	p.E672K	PLEKHG3_ENST00000492928.1_3'UTR|PLEKHG3_ENST00000484731.2_Missense_Mutation_p.E233K|PLEKHG3_ENST00000471182.2_Missense_Mutation_p.E261K|PLEKHG3_ENST00000394691.1_Missense_Mutation_p.E728K	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	728					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TGAAAATGCAGAACACCATGA	0.527000													36	92					0	0	0.00111076	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202657	140202658	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr5:140202657_140202658insA	ENST00000529859.1	+	1	1297_1298	c.1297_1298insA	c.(1297-1299)gctfs	p.A433fs	PCDHA1_ENST00000504120.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Frame_Shift_Ins_p.A433fs|PCDHA5_ENST00000378126.3_Frame_Shift_Ins_p.A433fs|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGGCTCGCCTTCGCTGTGGGCC	0.639													44	141	---	---	---	---					
FAM184A	79632	broad.mit.edu	37	6	119324685	119324686	+	Frame_Shift_Ins	INS	-	-	A			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr6:119324685_119324686insA	ENST00000338891.7	-	8	2360_2361	c.1917_1918insT	c.(1915-1920)atagtgfs	p.V640fs	RP11-351A11.1_ENST00000518570.1_RNA|FAM184A_ENST00000521531.1_Frame_Shift_Ins_p.V640fs|FAM184A_ENST00000368475.4_Frame_Shift_Ins_p.V520fs|FAM184A_ENST00000352896.5_Frame_Shift_Ins_p.V520fs	NM_024581.4	NP_078857.5	Q8NB25	F184A_HUMAN	family with sequence similarity 184, member A	640										breast(2)|central_nervous_system(2)|endometrium(2)|kidney(5)|large_intestine(19)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(5)	52						TCAGTCCACTTAATTTCTAAGT	0.347													24	50	---	---	---	---					
MAP3K4	4216	broad.mit.edu	37	6	161413044	161413045	+	In_Frame_Ins	INS	-	-	CCG			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr6:161413044_161413045insCCG	ENST00000392142.4	+	1	229_230	c.81_82insCCG	c.(79-84)cccgcc>ccCCGcgcc	p.27_28PA>PRA	MAP3K4_ENST00000348824.7_In_Frame_Ins_p.27_28PA>PRA|MAP3K4_ENST00000366919.2_In_Frame_Ins_p.27_28PA>PRA|MAP3K4_ENST00000366920.2_In_Frame_Ins_p.27_28PA>PRA	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	27	Poly-Pro.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		Agccgccgccaccgccgccgcc	0.738													4	4	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55249017	55249018	+	In_Frame_Ins	INS	-	-	CCA	rs121913445		TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr7:55249017_55249018insCCA	ENST00000275493.2	+	20	2492_2493	c.2315_2316insCCA	c.(2314-2316)cca>cCCAca	p.772_773insT	EGFR_ENST00000455089.1_In_Frame_Ins_p.727_728insT|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_In_Frame_Ins_p.719_720insT|EGFR-AS1_ENST00000442411.1_RNA	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	772	Protein kinase.				activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.P772_H773insX(2)|p.N771_P772>SVDNR(1)|p.P772_H773insTHP(1)|p.P772_H773insV(1)|p.P772_H773insHV(1)|p.H773>NPY(1)|p.P772P(1)|p.P772R(1)|p.D770_P772>ASVDNR(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GTGGACAACCCCCACGTGTGCC	0.644		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			129	166	---	---	---	---					
PPAPDC1A	196051	broad.mit.edu	37	10	122280537	122280539	+	In_Frame_Del	DEL	AAT	AAT	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr10:122280537_122280539delAAT	ENST00000398250.1	+	5	727_729	c.375_377delAAT	c.(373-378)gag>ga	p.EM125del	PPAPDC1A_ENST00000369073.3_In_Frame_Del_p.EM115del|PPAPDC1A_ENST00000439221.1_Intron|PPAPDC1A_ENST00000398248.1_Intron|PPAPDC1A_ENST00000541332.1_In_Frame_Del_p.EM125del	NM_001030059.1	NP_001025230.1	Q5VZY2	PPC1A_HUMAN	phosphatidic acid phosphatase type 2 domain containing 1A	125					phospholipid dephosphorylation	integral to membrane	phosphatidate phosphatase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|urinary_tract(1)	20		Lung NSC(174;0.1)|all_lung(145;0.132)		all cancers(201;0.0117)		TGAACTCGGAAATGCATTGCACA	0.493													20	42	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711145	6711147	+	In_Frame_Del	DEL	TCC	TCC	-	rs71584865	byFrequency	TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr12:6711145_6711147delTCC	ENST00000309577.6	-	4	580_582	c.417_419delGGA	c.(415-420)gat>ga	p.ED139del	CHD4_ENST00000544484.1_In_Frame_Del_p.ED136del|CHD4_ENST00000544040.1_In_Frame_Del_p.ED132del|CHD4_ENST00000357008.2_In_Frame_Del_p.ED139del			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	139	Poly-Asp.		E -> D (in dbSNP:rs1639122).		chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ATCATCATCAtcctcctcctcct	0.453													7	45	---	---	---	---					
ABCC4	10257	broad.mit.edu	37	13	95818595	95818595	+	Frame_Shift_Del	DEL	G	G	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr13:95818595delG	ENST00000376887.4	-	15	1965	c.1851delC	c.(1849-1851)tafs	p.Y617fs	ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000536256.1_Frame_Shift_Del_p.Y542fs|ABCC4_ENST00000412704.1_Frame_Shift_Del_p.Y617fs|ABCC4_ENST00000431522.1_Frame_Shift_Del_p.Y617fs	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	617	ABC transporter 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	GGAACTCAGTGTAAGTCCCCT	0.368													9	57	---	---	---	---					
SLC7A5	8140	broad.mit.edu	37	16	87870213	87870213	+	Frame_Shift_Del	DEL	A	A	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr16:87870213delA	ENST00000261622.4	-	8	1246	c.1181delT	c.(1180-1182)tcfs	p.F394fs	RP4-536B24.2_ENST00000563687.1_RNA|SLC7A5_ENST00000565644.1_Frame_Shift_Del_p.F128fs	NM_003486.5	NP_003477.4	Q01650	LAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 5	394					blood coagulation|cell differentiation|cellular amino acid metabolic process|ion transport|leukocyte migration|nervous system development	apical plasma membrane|cytosol|integral to membrane	neutral amino acid transmembrane transporter activity|peptide antigen binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(80;0.049)		GATGACGGAGAAGATGTCCTT	0.612													12	34	---	---	---	---					
SERTAD1	29950	broad.mit.edu	37	19	40929409	40929411	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr19:40929409_40929411delCTC	ENST00000357949.4	-	2	201_203	c.43_45delGAG	c.(43-45)del	p.E15del		NM_013376.3	NP_037508.2	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	15					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(2)|lung(1)|prostate(1)|skin(1)	5			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGGTTCCTTCTCCTCCTCCTCC	0.557													7	78	---	---	---	---					
TTC3	7267	broad.mit.edu	37	21	38555171	38555180	+	Frame_Shift_Del	DEL	ATCACTGAAG	ATCACTGAAG	-			TCGA-50-6673-01A-11D-1945-08	TCGA-50-6673-11A-02D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	fc6185f2-f1ea-43ea-8d4f-3b121949d06f	20683d9f-102f-4976-985f-97162ae99514	g.chr21:38555171_38555180delATCACTGAAG	ENST00000399017.2	+	36	7460_7469	c.4713_4722delATCACTGAAG	c.(4711-4722)aafs	p.KSLK1571fs	TTC3_ENST00000355666.1_Frame_Shift_Del_p.KSLK1571fs|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000354749.2_Frame_Shift_Del_p.KSLK1571fs	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1571	Arg/Lys-rich (basic).				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				AAAGACTAAAATCACTGAAGAAGAAAATTA	0.271													9	34	---	---	---	---					
