Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TPTE2P6	374491	broad.mit.edu	37	13	25168432	25168432	+	RNA	SNP	T	T	C	rs149337771	by1000genomes	TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr13:25168432T>C	ENST00000453498.1	+	0	1104																											TTGAAACAGCTGGTGTATTAA	0.373000													3	16					0	0	0.004672	0	0
POTEC	388468	broad.mit.edu	37	18	14524916	14524916	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr18:14524916G>C	ENST00000358970.5	-	7	1192	c.1193C>G	c.(1192-1194)cCa>cGa	p.P398R		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	398										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						CCATGCCTCTGGCTGGCTATT	0.313000													4	61					0	0	0.000248	0	0
THNSL2	55258	broad.mit.edu	37	2	88472698	88472698	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr2:88472698C>T	ENST00000324166.5	+	1	1720	c.29C>T	c.(28-30)gCc>gTc	p.A10V	THNSL2_ENST00000402102.1_Missense_Mutation_p.A10V|THNSL2_ENST00000377254.3_Missense_Mutation_p.A10V|THNSL2_ENST00000358591.2_Missense_Mutation_p.A10V|THNSL2_ENST00000343544.4_Missense_Mutation_p.A10V|THNSL2_ENST00000449349.1_Intron	NM_018271.4	NP_060741.3	Q86YJ6	THNS2_HUMAN	threonine synthase-like 2 (S. cerevisiae)	10					threonine biosynthetic process		threonine synthase activity			breast(4)|lung(17)|ovary(1)|prostate(3)|upper_aerodigestive_tract(2)	27						AGGGGCGTAGCCCCACGGGTC	0.617000													8	88					0	0	0.004482	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43625427	43625427	+	RNA	SNP	G	G	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr17:43625427G>C	ENST00000586348.1	+	0	45																											TCTGTAGTGGGTTCTGGAATG	0.507000													27	186					0	0	0.006320	0	0
DOK6	220164	broad.mit.edu	37	18	67365760	67365760	+	Missense_Mutation	SNP	T	T	A			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr18:67365760T>A	ENST00000382713.5	+	5	720	c.530T>A	c.(529-531)gTg>gAg	p.V177E	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	177	IRS-type PTB.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				GTCAAACTGGTGATGTGGCCT	0.473000													4	44					0	0	0.000248	0	0
PLA2R1	22925	broad.mit.edu	37	2	160862239	160862239	+	Silent	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr2:160862239C>T	ENST00000283243.7	-	11	1964	c.1758G>A	c.(1756-1758)acG>acA	p.T586T	PLA2R1_ENST00000392771.1_Silent_p.T586T	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	586	C-type lectin 3.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						TGTATTCTCCCGTATCATTTT	0.458000													9	83					0	0	0.004482	0	0
YBX2	51087	broad.mit.edu	37	17	7192945	7192945	+	Silent	SNP	G	G	A			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr17:7192945G>A	ENST00000007699.5	-	7	1011	c.948C>T	c.(946-948)ccC>ccT	p.P316P		NM_015982.3	NP_057066.2	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	316	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|skin(3)	12						GTGGGCGCTGGGGCTCAGGCC	0.721000													9	27					0	0	0.006214	0	0
CYYR1	116159	broad.mit.edu	37	21	27840918	27840918	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr21:27840918C>T	ENST00000299340.4	-	4	710	c.367G>A	c.(367-369)Gaa>Aaa	p.E123K	AP001596.6_ENST00000429340.1_RNA|AP001596.6_ENST00000444306.1_RNA|CYYR1_ENST00000435845.2_3'UTR|AP001597.1_ENST00000357401.3_RNA|AP001597.1_ENST00000414486.1_RNA|AP001596.6_ENST00000421771.1_RNA	NM_052954.2	NP_443186.1	Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	123						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						GCACAGTATTCCATCTCGTGG	0.507000													22	55					0	0	0.002780	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296167	39296167	+	Silent	SNP	A	A	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr17:39296167A>G	ENST00000345847.4	-	1	572	c.573T>C	c.(571-573)atT>atC	p.I191I		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	187						keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGCAGGTGGAAATGACACAGG	0.627000													3	13					0	0	0.000248	0	0
ZNF780A	284323	broad.mit.edu	37	19	40587729	40587729	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr19:40587729G>C	ENST00000450241.2	-	5	438	c.127C>G	c.(127-129)Cca>Gca	p.P43A	ZNF780A_ENST00000594395.1_Missense_Mutation_p.P78A|ZNF780A_ENST00000455521.1_Missense_Mutation_p.P78A|ZNF780A_ENST00000414720.2_Missense_Mutation_p.P93A|ZNF780A_ENST00000595687.2_Missense_Mutation_p.P77A|ZNF780A_ENST00000340963.5_Missense_Mutation_p.P77A|AC005614.5_ENST00000595508.1_RNA			O75290	Z780A_HUMAN	zinc finger protein 780A	77	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					CACTTACCTGGATACCGTCTG	0.448000													10	87					0	0	0.008291	0	0
ITGA5	3678	broad.mit.edu	37	12	54799449	54799449	+	Splice_Site	SNP	C	C	T	rs141341610	byFrequency	TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr12:54799449C>T	ENST00000293379.4	-	11	1276	c.1016_splice	c.e11+1	p.G339_splice	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	339					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						ACCACTCACCCATCCCCATTG	0.552000													9	62					0	0	0.001855	0	0
BCL10	8915	broad.mit.edu	37	1	85733383	85733383	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr1:85733383T>G	ENST00000370580.1	-	3	1366	c.629A>C	c.(628-630)gAa>gCa	p.E210A		NM_003921.4	NP_003912.1	O95999	BCL10_HUMAN	B-cell CLL/lymphoma 10	210			Missing (in follicular lymphoma).		apoptosis|cellular response to mechanical stimulus|innate immune response|interleukin-6 biosynthetic process|lymphotoxin A biosynthetic process|negative regulation of mature B cell apoptosis|neural tube closure|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 biosynthetic process|positive regulation of mast cell cytokine production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of transcription, DNA-dependent|protein homooligomerization|response to molecule of bacterial origin|T cell receptor signaling pathway	CBM complex|cytosol|lysosome|membrane raft|nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protease binding|protein C-terminus binding|protein kinase B binding|protein self-association|transcription coactivator activity|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	19				all cancers(265;0.0114)|Epithelial(280;0.0311)		TCCTTCTTCTTCTAACTGTAG	0.423000			T	IGH@	MALT								4	66					0	0	0.000248	0	0
CD8B	926	broad.mit.edu	37	2	87085348	87085348	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr2:87085348T>G	ENST00000390655.6	-	2	293	c.235A>C	c.(235-237)Act>Cct	p.T79P	CD8B_ENST00000349455.3_Missense_Mutation_p.T79P|CD8B_ENST00000431506.2_Intron|CD8B_ENST00000393761.2_Missense_Mutation_p.T79P|CD8B_ENST00000393759.2_Missense_Mutation_p.T79P|CD8B_ENST00000331469.2_Missense_Mutation_p.T79P	NM_004931.4	NP_004922.1	P10966	CD8B_HUMAN	CD8b molecule	79	Ig-like V-type.				immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	13						CCGTGGATAGTCCCTTTTGCG	0.557000													17	65					0	0	0.004990	0	0
CRHBP	1393	broad.mit.edu	37	5	76249905	76249905	+	Missense_Mutation	SNP	G	G	A	rs147365557		TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr5:76249905G>A	ENST00000274368.4	+	3	649	c.227G>A	c.(226-228)cGg>cAg	p.R76Q	CRHBP_ENST00000506501.1_Missense_Mutation_p.R76Q	NM_001882.3	NP_001873.2	P24387	CRHBP_HUMAN	corticotropin releasing hormone binding protein	76					female pregnancy|learning or memory|signal transduction	soluble fraction				kidney(3)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	16		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;2.17e-51)|Epithelial(54;8.79e-46)|all cancers(79;2.49e-41)		ACCGCCGACCGGCCGCAGCTG	0.652000													4	96					0	0	0.001984	0	0
BMS1P20	96610	broad.mit.edu	37	22	22663086	22663086	+	RNA	SNP	T	T	G	rs1054157	by1000genomes	TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr22:22663086T>G	ENST00000426066.1	+	0	525					NR_027293.1																						AGCTGCCACATAAGTTGTCCT	0.299000													3	31					0	0	0.000248	0	0
GFPT2	9945	broad.mit.edu	37	5	179757728	179757728	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr5:179757728G>A	ENST00000253778.8	-	6	675	c.506C>T	c.(505-507)aCg>aTg	p.T169M		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	169	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CTCGACCAACGTTGAAAACGT	0.388000													8	69					0	0	0.003080	0	0
ZAN	7455	broad.mit.edu	37	7	100391747	100391747	+	RNA	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr7:100391747C>T	ENST00000542585.1	+	0	8202				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TCTAGCTGGGCAGCAGCTTTC	0.642000													5	36					0	0	0.000602	0	0
MUL1	79594	broad.mit.edu	37	1	20827839	20827839	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr1:20827839C>T	ENST00000264198.3	-	4	539	c.403G>A	c.(403-405)Gtg>Atg	p.V135M		NM_024544.2	NP_078820.2	Q969V5	MUL1_HUMAN	mitochondrial E3 ubiquitin protein ligase 1	135					activation of caspase activity|activation of JUN kinase activity|induction of apoptosis|mitochondrial fission|mitochondrion localization|negative regulation of cell growth|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to mitochondrial outer membrane|nucleus|peroxisome	identical protein binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(5)	11		Colorectal(325;0.000147)|Renal(390;0.000469)|Lung NSC(340;0.00412)|all_lung(284;0.00419)|Breast(348;0.00748)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000137)|Kidney(64;0.00017)|GBM - Glioblastoma multiforme(114;0.00124)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)		GCCACATCCACGCCATCCTCG	0.507000													15	101					0	0	0.004990	0	0
WNK1	65125	broad.mit.edu	37	12	993965	993965	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr12:993965C>T	ENST00000537687.1	+	19	5418	c.4775C>T	c.(4774-4776)aCa>aTa	p.T1592I	WNK1_ENST00000535572.1_Missense_Mutation_p.T1085I|WNK1_ENST00000530271.2_Missense_Mutation_p.T1830I|WNK1_ENST00000340908.4_Missense_Mutation_p.T925I|WNK1_ENST00000315939.6_Missense_Mutation_p.T1332I	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1332					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			ACAGGACCAACATTTCCAGTA	0.493000													7	63					0	0	0.001984	0	0
NTM	50863	broad.mit.edu	37	11	132082022	132082022	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr11:132082022G>C	ENST00000374786.1	+	3	986	c.507G>C	c.(505-507)tgG>tgC	p.W169C	NTM_ENST00000425719.2_Missense_Mutation_p.W169C|NTM_ENST00000374784.1_Missense_Mutation_p.W169C|NTM_ENST00000374791.3_Missense_Mutation_p.W169C|NTM_ENST00000539799.1_Missense_Mutation_p.W169C|NTM_ENST00000474900.1_3'UTR|NTM_ENST00000427481.2_Missense_Mutation_p.W160C	NM_001144058.1|NM_016522.2	NP_001137530.1|NP_057606.1	Q9P121	NTRI_HUMAN	neurotrimin	169	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(4)|large_intestine(9)|lung(30)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	56						CGGTTACTTGGAGACACATCT	0.433000													3	102					0	0	0.004672	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													5	100					0	0	0.000602	0	0
SYNE2	23224	broad.mit.edu	37	14	64519395	64519395	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr14:64519395A>G	ENST00000358025.3	+	48	8994	c.8764A>G	c.(8764-8766)Att>Gtt	p.I2922V	SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000344113.4_Missense_Mutation_p.I2922V|SYNE2_ENST00000554584.1_Missense_Mutation_p.I2955V	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2922					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAATCTTAAGATTAGGACCAA	0.348000													6	18					0	0	0.001168	0	0
PLXNB2	23654	broad.mit.edu	37	22	50721832	50721832	+	Silent	SNP	C	C	T			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr22:50721832C>T	ENST00000449103.1	-	16	2753	c.2613G>A	c.(2611-2613)ggG>ggA	p.G871G	PLXNB2_ENST00000496720.1_5'UTR|PLXNB2_ENST00000359337.4_Silent_p.G871G			O15031	PLXB2_HUMAN	plexin B2	871	IPT/TIG 1.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTCGACACCCCCCGTGAAAG	0.662000													4	27					0	0	0.000248	0	0
MUC5B	727897	broad.mit.edu	37	11	1271623	1271623	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr11:1271623A>G	ENST00000447027.1	+	31	13580	c.13522A>G	c.(13522-13524)Act>Gct	p.T4508A	MUC5B_ENST00000529681.1_Missense_Mutation_p.T4505A			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4505	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		AGGGACTGCAACTGCCCTTCC	0.632000													12	181					0	0	0.001855	0	0
HTR1D	3352	broad.mit.edu	37	1	23520201	23520201	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr1:23520201A>G	ENST00000374619.1	-	1	1021	c.512T>C	c.(511-513)aTc>aCc	p.I171T	HTR1D_ENST00000314113.3_Missense_Mutation_p.I171T	NM_000864.4	NP_000855.1	P28221	5HT1D_HUMAN	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	171					G-protein signaling, coupled to cyclic nucleotide second messenger|intestine smooth muscle contraction|synaptic transmission	integral to plasma membrane	serotonin receptor activity			NS(1)|large_intestine(3)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	9		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000779)|all_lung(284;0.00135)|Breast(348;0.0385)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0561)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;4.69e-27)|Colorectal(126;4.86e-08)|COAD - Colon adenocarcinoma(152;2.86e-06)|GBM - Glioblastoma multiforme(114;0.00012)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(1967;0.00122)|STAD - Stomach adenocarcinoma(196;0.0123)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.083)|LUSC - Lung squamous cell carcinoma(448;0.185)	Almotriptan(DB00918)|Dihydroergotamine(DB00320)|Eletriptan(DB00216)|Ergotamine(DB00696)|Frovatriptan(DB00998)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Ziprasidone(DB00246)|Zolmitriptan(DB00315)	GAGCGGGGGGATGGAGATGCA	0.597000													3	70					0	0	0.000248	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													3	37					0	0	0.004672	0	0
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121137803	121137805	+	RNA	DEL	CCA	CCA	-	rs60375635	by1000genomes	TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr1:121137803_121137805delCCA	ENST00000437515.1	-	0	329																											ACCGCCGCCGCCACGGCTTTTTG	0.645													5	6	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55241679	55241681	+	In_Frame_Del	DEL	AAC	AAC	-			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr7:55241679_55241681delAAC	ENST00000275493.2	+	18	2304_2306	c.2127_2129delAAC	c.(2125-2130)gat>ga	p.ET709del	EGFR_ENST00000454757.2_In_Frame_Del_p.ET656del|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000455089.1_In_Frame_Del_p.ET664del	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	709			E -> A (found in a lung cancer sample).|E -> K (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E709H(2)|p.T710A(1)|p.E709_T710>D(1)|p.E709_T710>G(1)|p.E709_T710>A(1)|p.E709fs*1(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCTTGAAGGAAACTGAATTCAAA	0.567		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			18	58	---	---	---	---					
CTIF	9811	broad.mit.edu	37	18	46284770	46284771	+	Frame_Shift_Ins	INS	-	-	C			TCGA-55-6980-01A-11D-1945-08	TCGA-55-6980-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cbbf3b76-5a2d-4882-9a93-6ffa043abb59	79e91d69-af03-4bb9-9c1d-d07c81437507	g.chr18:46284770_46284771insC	ENST00000256413.3	+	8	1360_1361	c.1065_1066insC	c.(1063-1068)aaaaaafs	p.K355fs	CTIF_ENST00000382998.4_Frame_Shift_Ins_p.K355fs	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	355					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						GAAGGCTAAAGGAAAAGGTACC	0.515													25	247	---	---	---	---					
