Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IL2RB	3560	broad.mit.edu	37	22	37524438	37524438	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr22:37524438C>T	ENST00000216223.5	-	10	1552	c.1354G>A	c.(1354-1356)Gaa>Aaa	p.E452K		NM_000878.3	NP_000869.1	P14784	IL2RB_HUMAN	interleukin 2 receptor, beta	452					interspecies interaction between organisms|positive regulation of survival gene product expression|protein complex assembly	external side of plasma membrane|integral to plasma membrane	interleukin-2 receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(5)	23					Aldesleukin(DB00041)|Basiliximab(DB00074)|Daclizumab(DB00111)|Denileukin diftitox(DB00004)	ATCCTCTCTTCACCGGCCCCA	0.667000													9	10					0	0	0.000442599	0	0
KIAA0895	23366	broad.mit.edu	37	7	36373544	36373544	+	Silent	SNP	G	G	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:36373544G>T	ENST00000317020.6	-	4	1374	c.1074C>A	c.(1072-1074)ggC>ggA	p.G358G	KIAA0895_ENST00000338533.5_Silent_p.G396G|KIAA0895_ENST00000297063.6_Silent_p.G409G|KIAA0895_ENST00000480192.1_5'UTR|KIAA0895_ENST00000440378.1_Silent_p.G406G|KIAA0895_ENST00000453212.1_Silent_p.G164G|KIAA0895_ENST00000436884.1_Silent_p.G306G	NM_015314.2	NP_056129.2	Q8NCT3	K0895_HUMAN	KIAA0895	409										breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						TGACAAACCTGCCAATATCTT	0.448000													6	122					2.0095e-06	2.91377e-05	8.12818e-05	1	0
HLA-DMA	3108	broad.mit.edu	37	6	32918314	32918314	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr6:32918314T>C	ENST00000374843.4	-	2	440	c.355A>G	c.(355-357)Aaa>Gaa	p.K119E	XXbac-BPG181M17.5_ENST00000429234.1_Intron|HLA-DMA_ENST00000395305.3_Intron|HLA-DMA_ENST00000464392.1_Intron|HLA-DMA_ENST00000395303.3_Missense_Mutation_p.K119E	NM_006120.3	NP_006111.2	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM alpha	119						integral to membrane|MHC class II protein complex				kidney(1)|large_intestine(2)|lung(8)	11						ACCGGGATTTTCCCATCAAGT	0.488000													9	209					0	0	0.000442599	0	0
NOD1	10392	broad.mit.edu	37	7	30491515	30491515	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:30491515G>A	ENST00000222823.4	-	6	2043	c.1518C>T	c.(1516-1518)ccC>ccT	p.P506P		NM_006092.2	NP_006083.1	Q9Y239	NOD1_HUMAN	nucleotide-binding oligomerization domain containing 1	506	NACHT.				activation of MAPK activity|detection of bacterium|induction of apoptosis|inflammatory response|innate immune response|interleukin-8 biosynthetic process|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of dendritic cell antigen processing and presentation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	basolateral plasma membrane|cytosol	ATP binding|CARD domain binding|caspase activator activity|peptidoglycan binding|protein homodimerization activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|skin(2)	39						GGTCACCCCCGGGGCCCAGCT	0.627000													7	56					0	0	0.000274275	0	0
DMBT1	1755	broad.mit.edu	37	10	124339284	124339284	+	Silent	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:124339284C>T	ENST00000338354.3	+	10	976	c.870C>T	c.(868-870)ggC>ggT	p.G290G	DMBT1_ENST00000368909.3_Silent_p.G290G|DMBT1_ENST00000368956.2_Silent_p.G290G|DMBT1_ENST00000330163.4_Silent_p.G290G|DMBT1_ENST00000344338.3_Silent_p.G290G|DMBT1_ENST00000368955.3_Silent_p.G290G|DMBT1_ENST00000359586.6_Intron			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	290	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCCAGTTTGGCCAGGGCTCAG	0.597000													7	149					0	0	0.000274275	0	0
POLR3A	11128	broad.mit.edu	37	10	79779004	79779004	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:79779004T>C	ENST00000372371.3	-	9	1342	c.1205A>G	c.(1204-1206)aAt>aGt	p.N402S	POLR3A_ENST00000484760.1_5'UTR	NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	402					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			CCTCAAGAAATTGATGTTTGC	0.383000													9	50					0	0	0.000274275	0	0
CPPED1	55313	broad.mit.edu	37	16	12875100	12875100	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:12875100C>G	ENST00000381774.4	-	2	471	c.231G>C	c.(229-231)aaG>aaC	p.K77N	CPPED1_ENST00000261660.4_Missense_Mutation_p.K77N|CPPED1_ENST00000433677.2_Missense_Mutation_p.K77N	NM_018340.2	NP_060810.2	Q9BRF8	CPPED_HUMAN	calcineurin-like phosphoesterase domain containing 1	77				K -> E (in Ref. 2; BAA92034).			hydrolase activity|metal ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|urinary_tract(1)	18						TGGGGTTCAGCTTGTTGATGG	0.562000													3	41					0	0	6.4e-05	0	0
MIR371B	100616185	broad.mit.edu	37	19	54290965	54290965	+	RNA	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr19:54290965G>A	ENST00000595160.1	-	0	331				MIR371A_ENST00000362161.1_RNA	NR_029864.1|NR_029865.1|NR_039909.1																						TCTGCTCTCTGGTGAAAGTGC	0.557000													6	36					0	0	3.59834e-05	0	0
MOGAT3	346606	broad.mit.edu	37	7	100843556	100843556	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:100843556G>A	ENST00000223114.4	-	3	413	c.247C>T	c.(247-249)Cgg>Tgg	p.R83W	MOGAT3_ENST00000379423.3_Missense_Mutation_p.R83W|MOGAT3_ENST00000440203.2_Missense_Mutation_p.R83W	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	83					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					CAAATTGCCCGGTTCCTTATC	0.562000													29	200					0	0	0.000409698	0	0
UGT1A10	54575	broad.mit.edu	37	2	234545643	234545643	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:234545643A>G	ENST00000344644.5	+	1	544	c.475A>G	c.(475-477)Aaa>Gaa	p.K159E	UGT1A10_ENST00000373445.1_Missense_Mutation_p.K159E|UGT1A8_ENST00000373450.4_Intron	NM_019075.2	NP_061948.1														endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(2)|skin(3)	32		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		AATTGTTGCTAAATATTTCTC	0.423000													26	132					0	0	0.000227799	0	0
DMBT1	1755	broad.mit.edu	37	10	124377716	124377716	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:124377716A>G	ENST00000338354.3	+	38	4794	c.4688A>G	c.(4687-4689)cAg>cGg	p.Q1563R	DMBT1_ENST00000368909.3_Missense_Mutation_p.Q1563R|DMBT1_ENST00000368956.2_Missense_Mutation_p.Q935R|DMBT1_ENST00000330163.4_Missense_Mutation_p.Q935R|DMBT1_ENST00000344338.3_Missense_Mutation_p.Q1553R|DMBT1_ENST00000368955.3_Missense_Mutation_p.Q1553R|DMBT1_ENST00000359586.6_Missense_Mutation_p.Q414R			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1563	SRCR 12.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGAAATGCCCAGTTTGGCCAG	0.612000													5	229					0	0	0.000157383	0	0
PCBP3	54039	broad.mit.edu	37	21	47360050	47360050	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr21:47360050G>A	ENST00000400314.1	+	15	1354	c.1016G>A	c.(1015-1017)cGt>cAt	p.R339H	PCBP3_ENST00000400310.1_Missense_Mutation_p.R319H|PCBP3_ENST00000468429.1_3'UTR|PCBP3_ENST00000449640.1_Missense_Mutation_p.R339H|PCBP3_ENST00000400304.1_Missense_Mutation_p.R329H|PCBP3_ENST00000400308.1_Missense_Mutation_p.R313H|PCBP3_ENST00000400309.1_Missense_Mutation_p.R338H			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	339	KH 3.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TCCTCAGAGCGTCAGATCACC	0.557000													11	46					0	0	6.40141e-05	0	0
FAT2	2196	broad.mit.edu	37	5	150931118	150931118	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr5:150931118G>A	ENST00000261800.5	-	6	4218	c.4206C>T	c.(4204-4206)atC>atT	p.I1402I		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1402	Cadherin 12.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TGGCAATGACGATGCTGCCTG	0.522000													7	63					0	0	0.000274275	0	0
SDF4	51150	broad.mit.edu	37	1	1158663	1158663	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:1158663C>T	ENST00000263741.7	-	4	830	c.538G>A	c.(538-540)Gcc>Acc	p.A180T	SDF4_ENST00000545427.1_Missense_Mutation_p.A180T|SDF4_ENST00000360001.6_Missense_Mutation_p.A180T	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	180					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		AGCCTGATGGCGTCGGCAACC	0.562000													20	111					0	0	0.000375601	0	0
GPR35	2859	broad.mit.edu	37	2	241569479	241569479	+	Missense_Mutation	SNP	T	T	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:241569479T>G	ENST00000319838.5	+	6	1052	c.110T>G	c.(109-111)cTc>cGc	p.L37R	GPR35_ENST00000438013.2_Missense_Mutation_p.L68R|GPR35_ENST00000430267.1_Missense_Mutation_p.L37R|GPR35_ENST00000407714.1_Missense_Mutation_p.L37R|GPR35_ENST00000403859.1_Missense_Mutation_p.L37R	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	37						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GGCCTGCTGCTCAACAGCCTG	0.642000													5	50					0	0	0.000602214	0	0
OR52E6	390078	broad.mit.edu	37	11	5862669	5862669	+	Silent	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr11:5862669C>T	ENST00000329322.5	-	1	458	c.459G>A	c.(457-459)agG>agA	p.R153R	TRIM5_ENST00000380027.1_Intron|OR52E6_ENST00000379946.2_Silent_p.R157R	NM_001005167.1	NP_001005167.1	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E, member 6	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTACAAGCTCCTCAGGACAG	0.483000													7	204					0	0	8.12818e-05	0	0
RAB40C	57799	broad.mit.edu	37	16	675984	675984	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:675984C>T	ENST00000535977.1	+	6	650	c.428C>T	c.(427-429)gCg>gTg	p.A143V	RAB40C_ENST00000248139.3_Missense_Mutation_p.A143V|RAB40C_ENST00000539661.1_Missense_Mutation_p.A143V|RAB40C_ENST00000538492.1_Missense_Mutation_p.A143V	NM_001172663.1	NP_001166134.1	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	143					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			NS(1)|endometrium(2)|large_intestine(1)|lung(1)|prostate(1)	6		Hepatocellular(780;0.0218)				CAGGCCCGCGCGTACGCAGAG	0.617000													11	31					0	0	6.40141e-05	0	0
HVCN1	84329	broad.mit.edu	37	12	111099246	111099246	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr12:111099246G>A	ENST00000356742.5	-	3	782	c.29C>T	c.(28-30)aCc>aTc	p.T10I	HVCN1_ENST00000439744.2_5'UTR|HVCN1_ENST00000242607.8_Missense_Mutation_p.T10I|HVCN1_ENST00000548312.1_Missense_Mutation_p.T10I			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	10					response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						GGCCCTGCGGGTGACTGCCTA	0.602000													5	25					0	0	0.000602214	0	0
TRMT5	57570	broad.mit.edu	37	14	61446337	61446337	+	Silent	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:61446337T>C	ENST00000261249.6	-	2	663	c.279A>G	c.(277-279)acA>acG	p.T93T	RP11-193F5.1_ENST00000553946.1_RNA	NM_020810.2	NP_065861.2	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	93						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(1)	11				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		GAATGTTGACTGTCTTTTTAA	0.423000													15	192					0	0	0.000566183	0	0
GNPNAT1	64841	broad.mit.edu	37	14	53250176	53250176	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:53250176G>C	ENST00000216410.3	-	3	369	c.182C>G	c.(181-183)aCa>aGa	p.T61R	GNPNAT1_ENST00000554230.1_5'UTR	NM_198066.3	NP_932332.1	Q96EK6	GNA1_HUMAN	glucosamine-phosphate N-acetyltransferase 1	61	N-acetyltransferase.				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|endosome membrane|Golgi membrane	glucosamine 6-phosphate N-acetyltransferase activity			liver(1)|lung(1)|prostate(1)|skin(1)	4	Breast(41;0.176)					TCCAGTCTCTGTTAGCTGACC	0.318000													3	95					0	0	0.000602214	0	0
WHSC1	7468	broad.mit.edu	37	4	1961303	1961303	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr4:1961303G>C	ENST00000382895.3	+	19	3522	c.3091G>C	c.(3091-3093)Gag>Cag	p.E1031Q	WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Missense_Mutation_p.E379Q|WHSC1_ENST00000382891.5_Missense_Mutation_p.E1031Q|WHSC1_ENST00000382892.2_Missense_Mutation_p.E1031Q|WHSC1_ENST00000508803.1_Missense_Mutation_p.E1031Q	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1031	AWS.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CTTTGATTCGGAGTGTCTGAA	0.527000			T	IGH@	MM								7	54					0	0	0.000157383	0	0
ZNF462	58499	broad.mit.edu	37	9	109773236	109773236	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr9:109773236G>C	ENST00000277225.5	+	13	7735	c.7446G>C	c.(7444-7446)aaG>aaC	p.K2482N	ZNF462_ENST00000441147.2_Missense_Mutation_p.K1388N|RP11-508N12.2_ENST00000439901.1_RNA|ZNF462_ENST00000542028.1_Missense_Mutation_p.K439N|ZNF462_ENST00000457913.1_Missense_Mutation_p.K2542N			Q96JM2	ZN462_HUMAN	zinc finger protein 462	2482					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						TTTCCCTAAAGAATGAAACAG	0.413000													6	19					0	0	8.12818e-05	0	0
CDYL2	124359	broad.mit.edu	37	16	80718848	80718848	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:80718848G>C	ENST00000299564.8	-	2	358	c.203C>G	c.(202-204)tCa>tGa	p.S68*	CDYL2_ENST00000562812.1_Nonsense_Mutation_p.S68*|CDYL2_ENST00000566173.1_Nonsense_Mutation_p.S68*|CDYL2_ENST00000562753.1_5'UTR|CDYL2_ENST00000563890.1_Nonsense_Mutation_p.S68*	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	68						nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						CTGCTTCCCTGACTTGATCCT	0.547000													22	74					0	0	0.000586117	0	0
COL4A4	1286	broad.mit.edu	37	2	227872966	227872966	+	Missense_Mutation	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:227872966T>C	ENST00000396625.3	-	47	4784	c.4577A>G	c.(4576-4578)aAc>aGc	p.N1526S	COL4A4_ENST00000329662.7_Missense_Mutation_p.N1523S	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1526	Collagen IV NC1.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CTGGTGGATGTTGCAGTAGGC	0.582000													3	33					0	0	6.4e-05	0	0
OGDH	4967	broad.mit.edu	37	7	44687313	44687313	+	Missense_Mutation	SNP	G	G	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:44687313G>T	ENST00000222673.5	+	4	514	c.472G>T	c.(472-474)Gac>Tac	p.D158Y	OGDH_ENST00000543843.1_Intron|OGDH_ENST00000449767.1_Intron|OGDH_ENST00000447398.1_Intron|OGDH_ENST00000443864.2_Missense_Mutation_p.D158Y|OGDH_ENST00000439616.2_Intron|OGDH_ENST00000444676.1_Missense_Mutation_p.D158Y	NM_002541.3	NP_002532.2	Q02218	ODO1_HUMAN	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	158					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			breast(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	36					NADH(DB00157)	TGCTGATCTGGACTCCTCCGT	0.557000													18	148					1.10513e-12	1.70386e-11	0.000295444	1	0
OR14C36	127066	broad.mit.edu	37	1	248512522	248512522	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:248512522G>A	ENST00000317861.1	+	1	446	c.446G>A	c.(445-447)aGt>aAt	p.S149N		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						TCCCTACTCAGTGGTCTTGTC	0.527000													5	66					0	0	0.000602214	0	0
DMBT1	1755	broad.mit.edu	37	10	124339221	124339221	+	Silent	SNP	T	T	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:124339221T>C	ENST00000338354.3	+	10	913	c.807T>C	c.(805-807)aaT>aaC	p.N269N	DMBT1_ENST00000368909.3_Silent_p.N269N|DMBT1_ENST00000368956.2_Silent_p.N269N|DMBT1_ENST00000330163.4_Silent_p.N269N|DMBT1_ENST00000344338.3_Silent_p.N269N|DMBT1_ENST00000368955.3_Silent_p.N269N|DMBT1_ENST00000359586.6_Intron			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	269	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				ATGATGCCAATGTGGTCTGCA	0.607000													20	289					0	0	0.000375601	0	0
TANK	10010	broad.mit.edu	37	2	162036222	162036222	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:162036222C>T	ENST00000392749.2	+	2	288	c.49C>T	c.(49-51)Cgg>Tgg	p.R17W	TANK_ENST00000403609.1_Missense_Mutation_p.R17W|TANK_ENST00000405852.1_Missense_Mutation_p.R17W|TANK_ENST00000402568.1_Missense_Mutation_p.R75W|TANK_ENST00000406287.1_Missense_Mutation_p.R75W|TANK_ENST00000457476.1_Missense_Mutation_p.R17W|TANK_ENST00000259075.2_Missense_Mutation_p.R17W	NM_001199135.1	NP_001186064.1	Q92844	TANK_HUMAN	TRAF family member-associated NFKB activator	17						cytosol	metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)	21						TGAAGCCTTCCGGCAGGCATG	0.403000													4	30					0	0	0.000602214	0	0
BSN	8927	broad.mit.edu	37	3	49692949	49692949	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr3:49692949C>T	ENST00000296452.4	+	5	6074	c.5960C>T	c.(5959-5961)aCc>aTc	p.T1987I		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1987					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		ATGTCTGACACCAATTTGGCT	0.627000													4	29					0	0	0.000602214	0	0
CROCCP3	114819	broad.mit.edu	37	1	16809784	16809784	+	RNA	SNP	T	T	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:16809784T>G	ENST00000263511.4	-	0	2001					NR_023386.1																						CCCGGCACCTTCTCAGGAGCT	0.632000													2	5					0	0	6.4e-05	0	0
DSG3	1830	broad.mit.edu	37	18	29044158	29044158	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr18:29044158C>T	ENST00000257189.4	+	9	1167	c.1084C>T	c.(1084-1086)Cga>Tga	p.R362*		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	362	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGTTATCTCTCGATACCGAGT	0.378000													13	45					0	0	0.000219431	0	0
LRP4	4038	broad.mit.edu	37	11	46880755	46880755	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr11:46880755G>A	ENST00000378623.1	-	38	5739	c.5497C>T	c.(5497-5499)Cgg>Tgg	p.R1833W	LRP4-AS1_ENST00000531719.1_RNA|LRP4-AS1_ENST00000502049.2_RNA	NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1833					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		AGGCCCCCCCGTGAGCTTCGC	0.562000													22	68					0	0	0.000295444	0	0
CACNA1G	8913	broad.mit.edu	37	17	48655855	48655855	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr17:48655855A>G	ENST00000352832.5	+	9	2603	c.2231A>G	c.(2230-2232)tAc>tGc	p.Y744C	CACNA1G_ENST00000512389.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000360761.4_Missense_Mutation_p.Y744C|CACNA1G_ENST00000358244.5_Missense_Mutation_p.Y744C|CACNA1G_ENST00000502264.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000354983.4_Missense_Mutation_p.Y744C|CACNA1G_ENST00000510366.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000442258.2_Missense_Mutation_p.Y744C|CACNA1G_ENST00000359106.5_Missense_Mutation_p.Y744C|CACNA1G_ENST00000416767.4_Missense_Mutation_p.Y744C|CACNA1G_ENST00000429973.2_Missense_Mutation_p.Y744C|CACNA1G_ENST00000514181.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000515765.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000503485.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000515411.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000515165.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000514079.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000507896.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000514717.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000507510.2_Missense_Mutation_p.Y744C|CACNA1G_ENST00000507609.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000505165.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000507336.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000513964.1_Missense_Mutation_p.Y744C|CACNA1G_ENST00000513689.2_Missense_Mutation_p.Y744C|CACNA1G_ENST00000510115.1_Missense_Mutation_p.Y744C	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	744					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GACAGCAAGTACTTTGGCCGG	0.592000													6	66					0	0	3.59834e-05	0	0
HSP90AB2P	391634	broad.mit.edu	37	4	13338269	13338269	+	RNA	SNP	G	G	A	rs114664012	by1000genomes	TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr4:13338269G>A	ENST00000602906.1	+	0	287																				kidney(3)|lung(1)	4						GACAAGATTCGCTATGAAAGC	0.428000													16	39					0	0	0.000422831	0	0
RANBP2	5903	broad.mit.edu	37	2	109384184	109384184	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:109384184G>C	ENST00000283195.6	+	20	7315	c.7189G>C	c.(7189-7191)Ggg>Cgg	p.G2397R		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2397	RanBD1 3.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						AAATATGAAAGGGACAGAAAG	0.373000													8	623					0	0	6.40141e-05	0	0
G2E3	55632	broad.mit.edu	37	14	31077238	31077238	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:31077238A>G	ENST00000206595.6	+	12	1617	c.1463A>G	c.(1462-1464)gAt>gGt	p.D488G	G2E3_ENST00000553504.1_Missense_Mutation_p.D518G|G2E3_ENST00000438909.2_Missense_Mutation_p.D442G	NM_017769.3	NP_060239.2	Q7L622	G2E3_HUMAN	G2/M-phase specific E3 ubiquitin protein ligase	488	HECT.				apoptosis|multicellular organismal development|protein modification process	Golgi apparatus|nucleolus	acid-amino acid ligase activity|protein binding|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						ATTTTAGATGATGTTTCAGAC	0.343000													10	106					0	0	0.000151284	0	0
LPAR4	2846	broad.mit.edu	37	X	78010493	78010493	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chrX:78010493G>A	ENST00000435339.2	+	2	532	c.127G>A	c.(127-129)Ggt>Agt	p.G43S	RP11-475D8.1_ENST00000514744.1_RNA|LPAR4_ENST00000373301.2_Missense_Mutation_p.G43S	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	43						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						TAATCTCAATGGTGCTGTCTA	0.408000													21	261					0	0	0.000295444	0	0
SVOP	55530	broad.mit.edu	37	12	109309580	109309580	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr12:109309580G>C	ENST00000299134.5	-	13	1222	c.1223C>G	c.(1222-1224)tCa>tGa	p.S408*		NM_018711.2	NP_061181.1	Q8N4V2	SVOP_HUMAN	SV2 related protein homolog (rat)	0						cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity			breast(2)|lung(4)	6						ACGGAGTGATGAGAGCACCCA	0.612000													4	14					0	0	0.000602214	0	0
TAS2R1	50834	broad.mit.edu	37	5	9630087	9630087	+	Missense_Mutation	SNP	C	C	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr5:9630087C>A	ENST00000382492.2	-	1	376	c.58G>T	c.(58-60)Ggg>Tgg	p.G20W	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	20					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						GTGAAAATCCCAAGAAGAAAT	0.348000													20	56					8.10497e-08	1.21875e-06	0.000175454	1	0
IPO4	79711	broad.mit.edu	37	14	24652208	24652208	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:24652208C>T	ENST00000354464.6	-	23	2571	c.2395G>A	c.(2395-2397)Gtg>Atg	p.V799M	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	799					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		GCCTTGAGCACGCCACAGAGC	0.677000													15	56					0	0	0.000219431	0	0
LOC440040	440040	broad.mit.edu	37	11	49597962	49597962	+	RNA	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr11:49597962G>A	ENST00000527477.1	+	0	566																											TTCATGAGAGGAAGTGTGGGG	0.522000													4	23					0	0	0.000602214	0	0
TAAR5	9038	broad.mit.edu	37	6	132910007	132910007	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr6:132910007C>T	ENST00000258034.2	-	1	870	c.819G>A	c.(817-819)atG>atA	p.M273I		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	273					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GGCTGTCGACCATCGTGTCTA	0.517000													11	90					0	0	6.40141e-05	0	0
MAGI2	9863	broad.mit.edu	37	7	77764449	77764449	+	Silent	SNP	G	G	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:77764449G>T	ENST00000354212.4	-	17	3173	c.2920C>A	c.(2920-2922)Cgg>Agg	p.R974R	MAGI2_ENST00000522391.1_Silent_p.R974R|MAGI2_ENST00000419488.1_Silent_p.R960R	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	974	PDZ 5.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				GCTAGGATCCGGTCTCCCACT	0.483000													5	159					8.12818e-05	0.00116472	8.12818e-05	1	0
RGPD4	285190	broad.mit.edu	37	2	108488724	108488724	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:108488724G>C	ENST00000408999.3	+	20	4341	c.4264G>C	c.(4264-4266)Ggg>Cgg	p.G1422R	RGPD4_ENST00000354986.4_Missense_Mutation_p.G1422R	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1422	RanBD1 2.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AAATATGAAAGGGACAGAAAG	0.378000													21	328					0	0	0.000375601	0	0
GRIA3	2892	broad.mit.edu	37	X	122598956	122598956	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chrX:122598956G>C	ENST00000264357.5	+	13	2609	c.2317G>C	c.(2317-2319)Gca>Cca	p.A773P	GRIA3_ENST00000371256.5_Missense_Mutation_p.A773P|AL356213.1_ENST00000577653.1_RNA|GRIA3_ENST00000371251.1_Missense_Mutation_p.A773P|GRIA3_ENST00000542149.1_Missense_Mutation_p.A773P	NM_000828.4	NP_000819.3	P42263	GRIA3_HUMAN	glutamate receptor, ionotropic, AMPA 3	773					glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			breast(2)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|pancreas(2)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	57					L-Glutamic Acid(DB00142)	TAAAGGCTCAGCATTAAGGTG	0.398000													5	75					0	0	0.000602214	0	0
DHX35	60625	broad.mit.edu	37	20	37643539	37643539	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr20:37643539C>T	ENST00000252011.3	+	14	1397	c.1364C>T	c.(1363-1365)tCg>tTg	p.S455L	DHX35_ENST00000373325.2_Missense_Mutation_p.S455L|DHX35_ENST00000373323.4_Missense_Mutation_p.S424L	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	455						catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				CCAGCACAGTCGATGGTTCAA	0.388000													14	120					0	0	0.000566183	0	0
DNAJC10	54431	broad.mit.edu	37	2	183584806	183584806	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:183584806C>T	ENST00000264065.6	+	4	692	c.277C>T	c.(277-279)Cgg>Tgg	p.R93W	DNAJC10_ENST00000537515.1_Missense_Mutation_p.R93W|DNAJC10_ENST00000469118.1_3'UTR	NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	93	J.				apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TGAAGATCTACGGAAAAAGTA	0.313000													6	56					0	0	8.12818e-05	0	0
TNR	7143	broad.mit.edu	37	1	175362964	175362964	+	Silent	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:175362964C>T	ENST00000367674.1	-	6	2016	c.1308G>A	c.(1306-1308)gaG>gaA	p.E436E	TNR_ENST00000263525.2_Silent_p.E436E	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	436	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					ATGAGAAGGGCTCCCACTGCA	0.463000													15	173					0	0	0.000422831	0	0
ZNF341	84905	broad.mit.edu	37	20	32378868	32378868	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr20:32378868G>A	ENST00000375200.1	+	15	2475	c.2110G>A	c.(2110-2112)Gcc>Acc	p.A704T	ZNF341_ENST00000342427.2_Missense_Mutation_p.A697T|RP4-553F4.6_ENST00000423074.1_RNA|RP4-553F4.6_ENST00000443171.1_RNA|RP4-553F4.6_ENST00000439444.1_RNA			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	704					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						GCATCAGCGCGCCCACACGGG	0.612000													5	35					0	0	0.000602214	0	0
CDK4	1019	broad.mit.edu	37	12	58145430	58145430	+	Missense_Mutation	SNP	C	C	A	rs104894340		TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr12:58145430C>A	ENST00000257904.6	-	2	436	c.71G>T	c.(70-72)cGt>cTt	p.R24L	CDK4_ENST00000549606.1_Intron|CDK4_ENST00000312990.6_Missense_Mutation_p.R24L|CDK4_ENST00000540325.1_5'UTR|CDK4_ENST00000551888.1_5'UTR	NM_000075.3	NP_000066.1	P11802	CDK4_HUMAN	cyclin-dependent kinase 4	24	Protein kinase.		R -> C (in CMM3; somatic and familial; generates a dominant oncogene resistant to inhibition by p16(INK4a); dbSNP:rs11547328).|R -> H (in CMM3).		cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding	p.R24L(1)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	21	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			GTGGGGATCACGGGCCTTGTA	0.557000			Mis			melanoma			Hereditary Melanoma				13	29					4.3838e-07	6.51155e-06	0.000151284	1	0
NCOA5	57727	broad.mit.edu	37	20	44691001	44691001	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr20:44691001G>C	ENST00000290231.6	-	8	1842	c.1678C>G	c.(1678-1680)Cag>Gag	p.Q560E		NM_020967.2	NP_066018.1	Q9HCD5	NCOA5_HUMAN	nuclear receptor coactivator 5	560	Transcription activation.				regulation of transcription, DNA-dependent|transcription, DNA-dependent|translation	nucleus	aminoacyl-tRNA ligase activity|ATP binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|skin(2)|urinary_tract(1)	21		Myeloproliferative disorder(115;0.0122)				GCTGTGGTCTGGCTAACCAGG	0.547000													4	30					0	0	0.000602214	0	0
ATG2B	55102	broad.mit.edu	37	14	96811066	96811066	+	Missense_Mutation	SNP	A	A	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr14:96811066A>C	ENST00000359933.4	-	4	1399	c.506T>G	c.(505-507)aTa>aGa	p.I169R		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	169										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		AACAGTATCTATAAAAGTGAC	0.294000													6	32					0	0	0.000274275	0	0
RUNX3	864	broad.mit.edu	37	1	25229017	25229017	+	Missense_Mutation	SNP	C	C	A	rs149811022		TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:25229017C>A	ENST00000399916.1	-	6	1324	c.886G>T	c.(886-888)Gcc>Tcc	p.A296S	RUNX3_ENST00000540420.1_Missense_Mutation_p.A189S|RUNX3_ENST00000308873.6_Missense_Mutation_p.A282S|RUNX3_ENST00000338888.3_Missense_Mutation_p.A296S	NM_001031680.2	NP_001026850.1	Q13761	RUNX3_HUMAN	runt-related transcription factor 3	282	Pro/Ser/Thr-rich.				cell proliferation|induction of apoptosis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|protein phosphorylation|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(3)	18		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00131)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0419)|OV - Ovarian serous cystadenocarcinoma(117;2.85e-26)|Colorectal(126;4.35e-08)|COAD - Colon adenocarcinoma(152;1.92e-06)|GBM - Glioblastoma multiforme(114;0.000102)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00148)|BRCA - Breast invasive adenocarcinoma(304;0.00173)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.136)		GAGGGCGTGGCGCTGTAGGGG	0.692000													24	66					4.72057e-08	7.18707e-07	0.000586117	1	0
FZD6	8323	broad.mit.edu	37	8	104331000	104331000	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr8:104331000G>A	ENST00000358755.4	+	3	677	c.360G>A	c.(358-360)gaG>gaA	p.E120E	FZD6_ENST00000540287.1_Intron|FZD6_ENST00000523739.1_Silent_p.E88E|FZD6_ENST00000522566.1_Silent_p.E120E	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	120	FZ.				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			GGCCTGAGGAGCTTGAATGTG	0.368000													6	44					0	0	3.59834e-05	0	0
PRKD3	23683	broad.mit.edu	37	2	37543552	37543552	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:37543552C>T	ENST00000379066.1	-	2	878	c.116G>A	c.(115-117)cGa>cAa	p.R39Q	PRKD3_ENST00000234179.2_Missense_Mutation_p.R39Q			O94806	KPCD3_HUMAN	protein kinase D3	39					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				ATTAGAGAGTCGGGCAGAGAG	0.517000													7	83					0	0	8.12818e-05	0	0
DMBT1	1755	broad.mit.edu	37	10	124339277	124339277	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr10:124339277A>G	ENST00000338354.3	+	10	969	c.863A>G	c.(862-864)cAg>cGg	p.Q288R	DMBT1_ENST00000368909.3_Missense_Mutation_p.Q288R|DMBT1_ENST00000368956.2_Missense_Mutation_p.Q288R|DMBT1_ENST00000330163.4_Missense_Mutation_p.Q288R|DMBT1_ENST00000344338.3_Missense_Mutation_p.Q288R|DMBT1_ENST00000368955.3_Missense_Mutation_p.Q288R|DMBT1_ENST00000359586.6_Intron			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	288	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGAAATGCCCAGTTTGGCCAG	0.607000													7	172					0	0	0.000442599	0	0
ADAM18	8749	broad.mit.edu	37	8	39564352	39564352	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr8:39564352G>A	ENST00000265707.5	+	18	1991	c.1946G>A	c.(1945-1947)aGa>aAa	p.R649K	ADAM18_ENST00000541111.1_Missense_Mutation_p.R63K|ADAM18_ENST00000523755.1_3'UTR|ADAM18_ENST00000379866.1_Missense_Mutation_p.R625K	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	649	EGF-like.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CCTGGACATAGACCTCCAGAT	0.348000													21	58					0	0	0.000295444	0	0
ECT2	1894	broad.mit.edu	37	3	172480505	172480505	+	Missense_Mutation	SNP	A	A	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr3:172480505A>T	ENST00000417960.1	+	10	1295	c.818A>T	c.(817-819)gAt>gTt	p.D273V	ECT2_ENST00000540509.1_Missense_Mutation_p.D305V|ECT2_ENST00000441497.2_Missense_Mutation_p.D274V|ECT2_ENST00000427830.1_Missense_Mutation_p.D274V|ECT2_ENST00000392692.3_Missense_Mutation_p.D305V|ECT2_ENST00000232458.5_Missense_Mutation_p.D274V	NM_001258316.1	NP_001245245.1	Q9H8V3	ECT2_HUMAN	epithelial cell transforming sequence 2 oncogene	274	BRCT 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity|signal transducer activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.33e-14)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)			CCGCTTGGAGATGAAAGATGC	0.333000													4	52					0	0	3.59834e-05	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202391825	202391825	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:202391825C>T	ENST00000406302.3	+	3	653	c.500C>T	c.(499-501)cCa>cTa	p.P167L	PPP1R12B_ENST00000336894.4_Missense_Mutation_p.P167L|PPP1R12B_ENST00000480184.1_Missense_Mutation_p.P167L|PPP1R12B_ENST00000356764.2_Missense_Mutation_p.P167L	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B	167					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			GCAGAAGAGCCAGCCATGAAG	0.458000													13	61					0	0	0.000219431	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118006474	118006474	+	Missense_Mutation	SNP	T	T	A	rs144274050		TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr4:118006474T>A	ENST00000310754.4	-	1	262	c.76A>T	c.(76-78)Atc>Ttc	p.I26F		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	26					protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						CAGGAGACGATGTCCGCATGA	0.562000													10	47					0	0	0.00010058	0	0
SCN5A	6331	broad.mit.edu	37	3	38674694	38674694	+	Silent	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr3:38674694G>A	ENST00000413689.1	-	2	298	c.105C>T	c.(103-105)ggC>ggT	p.G35G	SCN5A_ENST00000425664.1_Silent_p.G35G|SCN5A_ENST00000443581.1_Silent_p.G35G|SCN5A_ENST00000414099.2_Silent_p.G35G|SCN5A_ENST00000455624.2_Silent_p.G35G|SCN5A_ENST00000450102.2_Silent_p.G35G|SCN5A_ENST00000423572.2_Silent_p.G35G|SCN5A_ENST00000333535.4_Silent_p.G35G|SCN5A_ENST00000449557.2_Silent_p.G35G|SCN5A_ENST00000451551.2_Silent_p.G35G	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	35					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGGTGGTTGAGCCGCGGGCTT	0.637000													3	16					0	0	6.4e-05	0	0
KRT19P2	160313	broad.mit.edu	37	12	95228798	95228798	+	RNA	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr12:95228798G>A	ENST00000405395.2	+	0	569					NR_036685.1																						GCCCAGCTGGGCGATGTGCGA	0.577000													4	10					0	0	0.000602214	0	0
FLOT2	2319	broad.mit.edu	37	17	27208290	27208290	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr17:27208290G>A	ENST00000394906.2	-	11	1260	c.1183C>T	c.(1183-1185)Cgg>Tgg	p.R395W	FLOT2_ENST00000577789.1_5'UTR|FLOT2_ENST00000585169.1_Missense_Mutation_p.R340W|FLOT2_ENST00000394908.4_Missense_Mutation_p.R340W			Q14254	FLOT2_HUMAN	flotillin 2	340					cell adhesion|epidermis development	cell surface|endocytic vesicle|endosome|membrane fraction				endometrium(3)|lung(6)|prostate(1)|urinary_tract(1)	11	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;3.26e-06)|all cancers(11;1.76e-05)|BRCA - Breast invasive adenocarcinoma(11;0.00015)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			AGCTTCATCCGCTCAGCCTCT	0.612000													9	39					0	0	0.000673444	0	0
RABEPK	10244	broad.mit.edu	37	9	127969995	127969995	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr9:127969995A>G	ENST00000373544.1	+	4	372	c.206A>G	c.(205-207)gAt>gGt	p.D69G	RABEPK_ENST00000394125.4_Missense_Mutation_p.D69G|RABEPK_ENST00000259460.8_Missense_Mutation_p.D69G|RABEPK_ENST00000394124.4_Missense_Mutation_p.D69G|RABEPK_ENST00000373538.3_Missense_Mutation_p.D69G			Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	69					receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15						CACACCATGGATCTGGGTAAG	0.507000													10	78					0	0	0.000673444	0	0
DIAPH3	81624	broad.mit.edu	37	13	60545013	60545013	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr13:60545013G>C	ENST00000400324.4	-	16	2152	c.1932C>G	c.(1930-1932)atC>atG	p.I644M	DIAPH3_ENST00000400320.1_Missense_Mutation_p.I598M|DIAPH3_ENST00000400319.1_Missense_Mutation_p.I574M|DIAPH3_ENST00000400330.1_Missense_Mutation_p.I644M|DIAPH3_ENST00000377908.2_Missense_Mutation_p.I633M|DIAPH3_ENST00000267215.4_Missense_Mutation_p.I644M|DIAPH3_ENST00000465066.1_5'UTR	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	644	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TTCTCATGCTGATTTCAGGTT	0.338000													5	40					0	0	8.12818e-05	0	0
MCTS1	28985	broad.mit.edu	37	X	119739377	119739377	+	Missense_Mutation	SNP	A	A	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chrX:119739377A>G	ENST00000371315.3	+	2	663	c.130A>G	c.(130-132)Atc>Gtc	p.I44V	MCTS1_ENST00000487133.1_3'UTR|MCTS1_ENST00000371317.5_Missense_Mutation_p.I43V	NM_001137554.1	NP_001131026.1	Q9ULC4	MCTS1_HUMAN	malignant T cell amplified sequence 1	43					cell cycle|positive regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm	RNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|stomach(1)|urinary_tract(1)	10						GCTTAATCAAATCATGCCTAA	0.343000													4	139					0	0	0.00024832	0	0
CACNG3	10368	broad.mit.edu	37	16	24268206	24268206	+	Missense_Mutation	SNP	C	C	G			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:24268206C>G	ENST00000005284.3	+	1	1333	c.131C>G	c.(130-132)tCt>tGt	p.S44C		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	44					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		AGGACTAAATCTACAAGTGAT	0.453000													3	86					0	0	0.00024832	0	0
TMEM177	80775	broad.mit.edu	37	2	120439204	120439204	+	Missense_Mutation	SNP	G	G	C			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:120439204G>C	ENST00000424086.1	+	2	1248	c.775G>C	c.(775-777)Gcc>Ccc	p.A259P	TMEM177_ENST00000409951.1_Intron|TMEM177_ENST00000272521.6_Missense_Mutation_p.A259P|TMEM177_ENST00000496203.1_Intron|TMEM177_ENST00000401466.1_Missense_Mutation_p.A259P	NM_001105198.1	NP_001098668.1	Q53S58	TM177_HUMAN	transmembrane protein 177	259						integral to membrane				breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	13	Colorectal(110;0.196)					GGGCAACCTGGCCCTGCGCAG	0.587000													7	50					0	0	8.12818e-05	0	0
ISL1	3670	broad.mit.edu	37	5	50683467	50683467	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr5:50683467C>T	ENST00000230658.7	+	3	947	c.362C>T	c.(361-363)gCg>gTg	p.A121V	ISL1_ENST00000505475.2_3'UTR|ISL1_ENST00000511384.1_Missense_Mutation_p.A121V	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	121	LIM zinc-binding 2.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				GACGAATTTGCGCTTCGGGAG	0.632000													7	30					0	0	8.12818e-05	0	0
RCSD1	92241	broad.mit.edu	37	1	167654689	167654689	+	Missense_Mutation	SNP	C	C	T			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr1:167654689C>T	ENST00000367854.3	+	3	471	c.140C>T	c.(139-141)cCg>cTg	p.P47L	RCSD1_ENST00000537350.1_Intron	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	47										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CGAAGGAAACCGCCCTGTTCC	0.577000													7	46					0	0	8.12818e-05	0	0
UMODL1	89766	broad.mit.edu	37	21	43522353	43522353	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr21:43522353G>A	ENST00000400427.1	+	8	1444	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K	UMODL1_ENST00000400424.1_Missense_Mutation_p.E350K|UMODL1_ENST00000408910.2_Missense_Mutation_p.E422K|UMODL1_ENST00000408989.2_Missense_Mutation_p.E422K|C21orf128_ENST00000329015.2_3'UTR	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	422	Fibronectin type-III 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CAGCAGTGTGGAGTACCAGGA	0.438000													8	144					0	0	0.000274275	0	0
TUFM	7284	broad.mit.edu	37	16	28855408	28855408	+	Missense_Mutation	SNP	G	G	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr16:28855408G>A	ENST00000313511.3	-	8	1075	c.937C>T	c.(937-939)Cac>Tac	p.H313Y		NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	310						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						AGGCTCTTGTGGAACATCTCA	0.622000													11	62					0	0	0.000673444	0	0
PRPF40A	55660	broad.mit.edu	37	2	153547493	153547494	+	Splice_Site	INS	-	-	A			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr2:153547493_153547494insA	ENST00000410080.1	-	5	870		c.e5-1			NM_017892.3	NP_060362.3	O75400	PR40A_HUMAN	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)						mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|urinary_tract(1)	21						GATGCTGTACCTAAAAAATAAA	0.267													2	4	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55242468	55242482	+	In_Frame_Del	DEL	ATTAAGAGAAGCAAC	ATTAAGAGAAGCAAC	-	rs121913438		TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr7:55242468_55242482delATTAAGAGAAGCAAC	ENST00000275493.2	+	19	2415_2429	c.2238_2252delATTAAGAGAAGCAAC	c.(2236-2253)gaa>ga	p.ELREAT746del	EGFR_ENST00000455089.1_In_Frame_Del_p.ELREAT701del|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_In_Frame_Del_p.ELREAT693del	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	746	Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1007)|p.L747_P753>S(123)|p.L747_A750>P(82)|p.L747_T751del(76)|p.E746_S752>V(57)|p.L747_S752del(34)|p.L747_T751>P(21)|p.E746_T751>A(21)|p.L747_E749del(16)|p.E746_E749del(9)|p.T751_I759>N(8)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.L747S(6)|p.K745_E749del(6)|p.E746_T751>V(6)|p.E746_S752>A(6)|p.T751I(6)|p.E746_T751>VA(6)|p.L747_T751>Q(5)|p.E746_T751del(4)|p.E746_T751>I(4)|p.E746_S752>D(4)|p.E746_S752>I(4)|p.T751_I759>S(3)|p.E746_A750>IP(3)|p.L747P(3)|p.L747_S752>Q(3)|p.E746_T751>IP(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.L747_S752>QH(2)|p.E746_S752del(2)|p.A750_E758>P(2)|p.E746_P753>VS(2)|p.E746_A750>QP(2)|p.L747_K754del(2)|p.T751_I759del(2)|p.L747_K754>ST(1)|p.A750_K754del(1)|p.T751_I759>REA(1)|p.L747_P753del(1)|p.E746_A750>VP(1)|p.L747_K754>N(1)|p.E746_P753>IS(1)|p.E746_T751>L(1)|p.L747_R748>FP(1)|p.E749G(1)|p.L747_T751>A(1)|p.I744_E749>LKR(1)|p.E746_P753>LS(1)|p.E746_T751>Q(1)|p.E746_T751>S(1)|p.E746_P753>VQ(1)|p.E746_A750>DP(1)|p.A750_E758del(1)|p.E746V(1)|p.I744_A750>VK(1)|p.R748I(1)|p.K745_A750del(1)|p.T751_E758del(1)|p.R748K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CTATCAAGGAATTAAGAGAAGCAACATCTCCGAAA	0.479	E746_A750del(NCIH1650_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			66	108	---	---	---	---					
KIAA1429	25962	broad.mit.edu	37	8	95538800	95538800	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr8:95538800delG	ENST00000297591.5	-	8	1747	c.1672delC	c.(1672-1674)atfs	p.H558fs	KIAA1429_ENST00000437199.1_Frame_Shift_Del_p.H558fs|KIAA1429_ENST00000421249.2_Frame_Shift_Del_p.H558fs	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	558					mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TCATAGAAATGGCATTTTTGG	0.398													50	118	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26114737	26114737	+	RNA	DEL	C	C	-			TCGA-55-6981-01A-11D-1945-08	TCGA-55-6981-11A-01D-1945-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	89a3a647-cf21-447f-9df3-9e563662e076	468bfcb8-eaa3-4e1e-b4ee-f673d3531d54	g.chr20:26114737delC	ENST00000416563.1	-	0	97																											atctccaccaccaactgcatg	0.632													4	2	---	---	---	---					
