Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GP2	2813	broad.mit.edu	37	16	20335360	20335360	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr16:20335360C>T	ENST00000302555.5	-	3	462	c.313G>A	c.(313-315)Gag>Aag	p.E105K	GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.E105K|GP2_ENST00000341642.5_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	105						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ACACAGGTCTCCGACATCCTT	0.592000													39	69					0	0	0.840704	0	0
PTCHD3	374308	broad.mit.edu	37	10	27688056	27688056	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr10:27688056T>A	ENST00000438700.3	-	4	1588	c.1471A>T	c.(1471-1473)Aca>Tca	p.T491S		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	491	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GTGGTGATTGTAATAGACACT	0.413000													13	32					0	0	0.435327	0	0
LAMC3	10319	broad.mit.edu	37	9	133936562	133936562	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr9:133936562C>T	ENST00000361069.4	+	13	2432	c.2299C>T	c.(2299-2301)Cca>Tca	p.P767S	LAMC3_ENST00000480883.1_Intron	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	767	Laminin EGF-like 7.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		TACGACCATCCCAGAGAGCCG	0.677000													12	18					0	0	0.387290	0	0
OR2J2	26707	broad.mit.edu	37	6	29142088	29142088	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr6:29142088G>A	ENST00000377167.2	+	1	778	c.676G>A	c.(676-678)Gta>Ata	p.V226I		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TGCCCGGGCTGTACTGAGCAT	0.463000													5	100					0	0	0.307466	0	0
HMCN1	83872	broad.mit.edu	37	1	186056718	186056718	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:186056718G>T	ENST00000271588.4	+	60	9533	c.9304G>T	c.(9304-9306)Gag>Tag	p.E3102*	HMCN1_ENST00000367492.2_Nonsense_Mutation_p.E3102*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3102	Ig-like C2-type 29.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GATGATAACAGAGTCTACTCA	0.428000													17	91					2.35188e-11	3.32813e-11	0.539581	1	0
OTUB1	55611	broad.mit.edu	37	11	63764060	63764060	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:63764060A>G	ENST00000538426.1	+	4	322	c.278A>G	c.(277-279)tAt>tGt	p.Y93C	OTUB1_ENST00000535715.1_Missense_Mutation_p.Y93C|OTUB1_ENST00000541478.1_Intron|OTUB1_ENST00000543988.1_Missense_Mutation_p.Y63C|OTUB1_ENST00000428192.2_Missense_Mutation_p.Y93C|OTUB1_ENST00000422031.2_Missense_Mutation_p.Y130C|OTUB1_ENST00000543004.1_Missense_Mutation_p.Y102C	NM_017670.2	NP_060140.2	Q96FW1	OTUB1_HUMAN	OTU domain, ubiquitin aldehyde binding 1	93	OTU.				protein K48-linked deubiquitination	cytoplasm	NEDD8-specific protease activity|omega peptidase activity|ubiquitin binding|ubiquitin-specific protease activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)	6						AACTGTTTCTATCGGGCTTTC	0.592000													29	32					0	0	0.693898	0	0
OR4S2	219431	broad.mit.edu	37	11	55418704	55418704	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:55418704G>T	ENST00000312422.2	+	1	325	c.325G>T	c.(325-327)Gag>Tag	p.E109*		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				TGGTTGCACTGAGATCTTCAT	0.418000													20	111					2.37509e-13	3.49278e-13	0.592651	1	0
EIF4G2	1982	broad.mit.edu	37	11	10822541	10822541	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:10822541G>C	ENST00000526148.1	-	15	2017	c.1507C>G	c.(1507-1509)Cca>Gca	p.P503A	EIF4G2_ENST00000525681.1_Missense_Mutation_p.P503A|RP11-685M7.5_ENST00000532365.1_RNA|EIF4G2_ENST00000339995.5_Missense_Mutation_p.P503A|EIF4G2_ENST00000396525.2_Missense_Mutation_p.P465A	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	503					cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		GTGCGTGGTGGTTGTGCACTA	0.428000													4	49					0	0	0.184627	0	0
JPH2	57158	broad.mit.edu	37	20	42815110	42815110	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr20:42815110C>T	ENST00000372980.3	-	1	1108	c.236G>A	c.(235-237)cGc>cAc	p.R79H	JPH2_ENST00000342272.3_Missense_Mutation_p.R79H	NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	79	Gly-rich.				calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GTAGAGCCAGCGCCCCTTGGT	0.592000													3	59					0	0	0.115264	0	0
SNHG14	104472715	broad.mit.edu	37	15	25420090	25420090	+	RNA	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr15:25420090C>A	ENST00000441592.2	+	0	179				SNORD115-3_ENST00000363100.1_RNA																							ATGATGAGAACCTTATATTGT	0.498000													27	303					2.48779e-11	3.45527e-11	0.693898	1	0
CDC42BPG	55561	broad.mit.edu	37	11	64596984	64596984	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:64596984C>A	ENST00000342711.5	-	30	3925	c.3926G>T	c.(3925-3927)cGt>cTt	p.R1309L		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1309	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						CTCGTGGCCACGAGACTTGCG	0.652000													14	26					0.00244969	0.00258771	0.457914	1	0
PRRX1	5396	broad.mit.edu	37	1	170705309	170705309	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:170705309G>A	ENST00000239461.6	+	4	1033	c.720G>A	c.(718-720)caG>caA	p.Q240Q	PRRX1_ENST00000476867.2_3'UTR|PRRX1_ENST00000367760.3_3'UTR	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	240						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AGAGGAACCAGGTGCCAACAG	0.433000													34	72					0	0	0.750413	0	0
OR5L1	219437	broad.mit.edu	37	11	55579820	55579820	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:55579820G>T	ENST00000333973.2	+	1	967	c.878G>T	c.(877-879)aGa>aTa	p.R293I		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TACAGCCTGAGAAATAAAGAT	0.453000													4	38					0.000602214	0.000664207	0.184627	1	0
OR2M5	127059	broad.mit.edu	37	1	248308722	248308722	+	Silent	SNP	C	C	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:248308722C>G	ENST00000366476.1	+	1	273	c.273C>G	c.(271-273)tcC>tcG	p.S91S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GCAGCAAGTCCATTTCTATGG	0.463000													145	317					0	0	0.870114	0	0
ERCC6	2074	broad.mit.edu	37	10	50667157	50667157	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr10:50667157T>C	ENST00000355832.5	-	21	4264	c.4186A>G	c.(4186-4188)Aga>Gga	p.R1396G	RP11-123B3.2_ENST00000423283.1_RNA|ERCC6_ENST00000542458.1_Missense_Mutation_p.R766G	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	1396					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AGGTGGTTTCTAGCTCTCATT	0.512000								Direct reversal of damage;Nucleotide excision repair (NER)					18	76					0	0	0.520397	0	0
MTMR8	55613	broad.mit.edu	37	X	63444984	63444984	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chrX:63444984C>A	ENST00000453546.1	-	10	1761	c.1672G>T	c.(1672-1674)Ggc>Tgc	p.G558C	ASB12_ENST00000396130.2_Missense_Mutation_p.G174C|ASB12_ENST00000362002.2_Missense_Mutation_p.G183C			Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	0						nuclear envelope	protein tyrosine phosphatase activity	p.0?(2)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						TAGAGGGGGCCAGAACATGAA	0.562000													6	18					0.00198382	0.00212552	0.248553	1	0
NUP85	79902	broad.mit.edu	37	17	73206052	73206052	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:73206052G>T	ENST00000245544.4	+	3	333	c.262G>T	c.(262-264)Gag>Tag	p.E88*	NUP85_ENST00000541827.1_Nonsense_Mutation_p.E42*|NUP85_ENST00000447371.2_5'UTR|NUP85_ENST00000579324.1_5'UTR|NUP85_ENST00000579298.1_Nonsense_Mutation_p.E88*|NUP85_ENST00000449421.2_3'UTR	NM_024844.3	NP_079120.1	Q9BW27	NUP85_HUMAN	nucleoporin 85kDa	88					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|nuclear membrane|Nup107-160 complex|spindle	protein binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	16	all_lung(278;0.14)|Lung NSC(278;0.168)		all cancers(21;3.45e-06)			AATTGACGAAGAGTTGACTGG	0.403000													14	49					1.67942e-08	2.09927e-08	0.539581	1	0
TROAP	10024	broad.mit.edu	37	12	49724607	49724607	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr12:49724607C>T	ENST00000551245.1	+	13	2090	c.1979C>T	c.(1978-1980)cCc>cTc	p.P660L	TROAP_ENST00000257909.3_Missense_Mutation_p.P660L|TROAP_ENST00000547923.1_Missense_Mutation_p.P339L			Q12815	TROAP_HUMAN	trophinin associated protein	660	Cys-rich.				cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						AGTCTACCACCCTGCTGCAGT	0.607000													21	127					0	0	0.608945	0	0
L3MBTL3	84456	broad.mit.edu	37	6	130425623	130425623	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr6:130425623C>A	ENST00000529410.1	+	21	2268	c.1789C>A	c.(1789-1791)Cca>Aca	p.P597T	L3MBTL3_ENST00000526019.1_Missense_Mutation_p.P572T|L3MBTL3_ENST00000368136.2_Missense_Mutation_p.P597T|L3MBTL3_ENST00000368139.2_Missense_Mutation_p.P572T|L3MBTL3_ENST00000361794.2_Missense_Mutation_p.P597T|L3MBTL3_ENST00000533560.1_Missense_Mutation_p.P572T			Q96JM7	LMBL3_HUMAN	l(3)mbt-like 3 (Drosophila)	597					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|skin(4)|stomach(1)|urinary_tract(1)	43				GBM - Glioblastoma multiforme(226;0.0266)|OV - Ovarian serous cystadenocarcinoma(155;0.154)		CCGTATTTTTCCAGACCGCTT	0.378000													35	48					2.66277e-13	3.84053e-13	0.827153	1	0
ZNF148	7707	broad.mit.edu	37	3	124951371	124951371	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr3:124951371G>C	ENST00000360647.4	-	9	2684	c.2199C>G	c.(2197-2199)ttC>ttG	p.F733L	ZNF148_ENST00000492394.1_Missense_Mutation_p.F733L|ZNF148_ENST00000468369.1_Missense_Mutation_p.F83L|ZNF148_ENST00000544464.1_Missense_Mutation_p.F70L|SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000484491.1_Missense_Mutation_p.F733L|ZNF148_ENST00000497929.1_5'UTR|ZNF148_ENST00000485866.1_Missense_Mutation_p.F733L	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	733					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						AGGGAGCACGGAAGGGCTGTT	0.493000													22	61					0	0	0.592651	0	0
PRR12	57479	broad.mit.edu	37	19	50099261	50099261	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr19:50099261G>T	ENST00000418929.2	+	4	1681	c.1669G>T	c.(1669-1671)Ggt>Tgt	p.G557C		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	330	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGAGGCGGCGGTGAGGCCAG	0.692000													12	41					7.03913e-09	9.10232e-09	0.411799	1	0
DNAJB6	10049	broad.mit.edu	37	7	157174955	157174955	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:157174955A>T	ENST00000262177.4	+	6	567	c.362A>T	c.(361-363)gAc>gTc	p.D121V	DNAJB6_ENST00000452797.2_Missense_Mutation_p.D72V|DNAJB6_ENST00000429029.2_Missense_Mutation_p.D121V|DNAJB6_ENST00000443280.1_Intron	NM_058246.3	NP_490647.1	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	121	Gly/Phe-rich.|Interaction with HSP70.|Interaction with KRT18.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			central_nervous_system(1)|lung(1)|ovary(2)|stomach(1)	5	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		CCTTTTGAGGACTTCTTTGGG	0.418000													11	39					0	0	0.361761	0	0
GPRIN2	9721	broad.mit.edu	37	10	46999116	46999116	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr10:46999116G>T	ENST00000374314.4	+	1	1191	c.236G>T	c.(235-237)gGc>gTc	p.G79V	GPRIN2_ENST00000374317.1_Missense_Mutation_p.G79V			O60269	GRIN2_HUMAN	G protein regulated inducer of neurite outgrowth 2	79										breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)	18						CGGGCCTCTGGCCCCAAGGCG	0.701000													4	51					0.150653	0.154781	0.150653	1	0
ZFHX4	79776	broad.mit.edu	37	8	77617547	77617547	+	Silent	SNP	G	G	C	rs13250763		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr8:77617547G>C	ENST00000521891.2	+	2	1672	c.1224G>C	c.(1222-1224)ctG>ctC	p.L408L	ZFHX4_ENST00000518282.1_Silent_p.L408L|ZFHX4_ENST00000050961.6_Silent_p.L408L|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000455469.2_Silent_p.L408L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	408						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AAGTGAATCTGGGGGGGCTGT	0.537000										HNSCC(33;0.089)			7	16					0	0	0.248553	0	0
DNAH8	1769	broad.mit.edu	37	6	38843499	38843499	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr6:38843499G>A	ENST00000359357.3	+	51	7356	c.7102G>A	c.(7102-7104)Gaa>Aaa	p.E2368K	DNAH8_ENST00000441566.1_Missense_Mutation_p.E2332K|DNAH8_ENST00000449981.2_Missense_Mutation_p.E2585K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AGAAAGCAGAGAAAAGCTTGA	0.398000													4	43					0	0	0.217242	0	0
TECRL	253017	broad.mit.edu	37	4	65274985	65274985	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:65274985C>A	ENST00000381210.3	-	1	195	c.85G>T	c.(85-87)Gat>Tat	p.D29Y	TECRL_ENST00000507440.1_Missense_Mutation_p.D29Y	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	29					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						TTTCTCATATCATCCTTCAGT	0.428000													13	54					3.27435e-08	4.02584e-08	0.457914	1	0
CCDC57	284001	broad.mit.edu	37	17	80146200	80146200	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:80146200C>T	ENST00000389641.4	-	7	983	c.947G>A	c.(946-948)aGg>aAg	p.R316K	CCDC57_ENST00000392343.3_Missense_Mutation_p.R316K|CCDC57_ENST00000392347.1_Missense_Mutation_p.R316K			Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	316										endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	16	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			CTCCAGAACCCTGGTCTGCAG	0.652000													4	12					0	0	0.150653	0	0
KIDINS220	57498	broad.mit.edu	37	2	8919861	8919861	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr2:8919861G>A	ENST00000256707.3	-	18	2494	c.2313C>T	c.(2311-2313)gtC>gtT	p.V771V	KIDINS220_ENST00000427284.1_Silent_p.V771V|KIDINS220_ENST00000473731.1_Silent_p.V771V|KIDINS220_ENST00000418530.1_Silent_p.V729V|KIDINS220_ENST00000319688.5_Silent_p.V772V	NM_020738.2	NP_065789.1	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate, 220kDa	771	KAP NTPase.				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(25)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	60	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CATCGATGATGACCACCAGCC	0.463000													11	33					0	0	0.387290	0	0
LETM2	137994	broad.mit.edu	37	8	38250462	38250462	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr8:38250462G>T	ENST00000519476.2	+	3	750	c.450G>T	c.(448-450)atG>atT	p.M150I	LETM2_ENST00000297720.5_Missense_Mutation_p.M103I|LETM2_ENST00000524874.1_Missense_Mutation_p.M150I|LETM2_ENST00000523983.2_Missense_Mutation_p.M103I|LETM2_ENST00000379957.4_Missense_Mutation_p.M150I			Q2VYF4	LETM2_HUMAN	leucine zipper-EF-hand containing transmembrane protein 2	150	LETM1.					integral to membrane|mitochondrial inner membrane				NS(1)|large_intestine(1)|lung(3)|prostate(2)	7	all_cancers(2;6.77e-47)|all_epithelial(2;1.01e-50)|all_lung(3;1.25e-23)|Lung NSC(2;2.76e-23)|Colorectal(12;0.000442)|Esophageal squamous(3;0.00202)	all_lung(54;0.0657)|Hepatocellular(245;0.152)|Lung NSC(58;0.175)	Epithelial(3;1.17e-42)|all cancers(3;5.44e-38)|BRCA - Breast invasive adenocarcinoma(5;5.44e-27)|LUSC - Lung squamous cell carcinoma(2;7.12e-25)|Lung(2;4.49e-22)|COAD - Colon adenocarcinoma(9;0.114)			CTGCCAGAATGGTTTGGAGGC	0.373000													9	15					1.11149e-13	1.70126e-13	0.361761	1	0
SDCCAG3	10807	broad.mit.edu	37	9	139301868	139301868	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr9:139301868C>A	ENST00000298537.7	-	4	690	c.479G>T	c.(478-480)gGa>gTa	p.G160V	SDCCAG3_ENST00000371725.3_Missense_Mutation_p.G110V|SDCCAG3_ENST00000357365.3_Missense_Mutation_p.G183V	NM_006643.3	NP_006634.3	Q96C92	SDCG3_HUMAN	serologically defined colon cancer antigen 3	183						cytoplasm				NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)	16		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		CCCACTCCATCCGGTGTCCTC	0.622000													5	21					1.23904e-05	1.42966e-05	0.184627	1	0
PLD6	201164	broad.mit.edu	37	17	17106252	17106252	+	Silent	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:17106252C>A	ENST00000321560.3	-	2	616	c.588G>T	c.(586-588)cgG>cgT	p.R196R	RP11-45M22.4_ENST00000427497.3_3'UTR	NM_178836.3	NP_849158.2	Q8N2A8	PLD6_HUMAN	phospholipase D family, member 6	196					DNA methylation involved in gamete generation|lipid catabolic process|meiosis|mitochondrial fusion|P granule organization|piRNA metabolic process|spermatid development	integral to membrane|mitochondrial outer membrane	cardiolipin hydrolase activity|protein homodimerization activity			endometrium(1)|lung(1)	2						CCAGAAAAAGCCGCACGTACT	0.507000													21	43					3.62473e-10	4.94282e-10	0.608945	1	0
TP53	7157	broad.mit.edu	37	17	7578526	7578526	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:7578526C>A	ENST00000420246.2	-	5	536	c.404G>T	c.(403-405)tGc>tTc	p.C135F	TP53_ENST00000445888.2_Missense_Mutation_p.C135F|TP53_ENST00000359597.4_Missense_Mutation_p.C135F|TP53_ENST00000455263.2_Missense_Mutation_p.C135F|TP53_ENST00000269305.4_Missense_Mutation_p.C135F|TP53_ENST00000413465.2_Missense_Mutation_p.C135F	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	135	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		C -> F (in sporadic cancers; somatic mutation).|C -> G (in sporadic cancers; somatic mutation).|C -> R (in sporadic cancers; somatic mutation).|C -> S (in sporadic cancers; somatic mutation).|C -> T (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|C -> W (in sporadic cancers; somatic mutation).|C -> Y (in sporadic cancers; somatic mutation; decreased E6-mediated binding to E6-AP).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.C135Y(60)|p.C135F(43)|p.C135S(8)|p.0?(8)|p.C42Y(4)|p.C3Y(4)|p.C135fs*9(3)|p.N131fs*27(2)|p.C3F(2)|p.C42F(2)|p.F134_T140>S(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.V73fs*9(1)|p.C135fs*15(1)|p.C135fs*14(1)|p.Y126fs*11(1)|p.C3fs*9(1)|p.C42fs*9(1)|p.C135_A138delCQLA(1)|p.C42S(1)|p.M133fs*13(1)|p.C3S(1)|p.C135_T140delCQLAKT(1)|p.Q136fs*13(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGCCAGTTGGCAAAACATCTT	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			10	28					7.48243e-07	8.76847e-07	0.335167	1	0
KIAA1109	84162	broad.mit.edu	37	4	123192658	123192658	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:123192658G>A	ENST00000264501.4	+	47	8352	c.7979G>A	c.(7978-7980)aGa>aAa	p.R2660K	KIAA1109_ENST00000388738.3_Missense_Mutation_p.R2660K|KIAA1109_ENST00000455637.1_Missense_Mutation_p.R2660K			Q2LD37	K1109_HUMAN	KIAA1109	2660					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TCATTAGGAAGATCTGAAAGA	0.353000													4	20					0	0	0.150653	0	0
GPA33	10223	broad.mit.edu	37	1	167042703	167042703	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:167042703G>A	ENST00000367868.3	-	2	460	c.117C>T	c.(115-117)gtC>gtT	p.V39V	GPA33_ENST00000527955.1_5'UTR	NM_005814.1	NP_005805.1	Q99795	GPA33_HUMAN	glycoprotein A33 (transmembrane)	39	Ig-like V-type.					integral to plasma membrane	receptor activity			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						AGGGCAGGGTGACACTCTTTC	0.532000													12	33					0	0	0.411799	0	0
GRID1	2894	broad.mit.edu	37	10	87373269	87373269	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr10:87373269G>A	ENST00000327946.7	-	15	2581	c.2496C>T	c.(2494-2496)gcC>gcT	p.A832A	GRID1_ENST00000536331.1_Silent_p.A403A	NM_017551.2	NP_060021.1	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	832						cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(46)|ovary(5)|prostate(4)|skin(5)|stomach(4)|upper_aerodigestive_tract(5)	106					L-Glutamic Acid(DB00142)	AGAAGACCCCGGCGAAGCTGT	0.657000										Multiple Myeloma(13;0.14)			4	60					0	0	0.150653	0	0
BRWD3	254065	broad.mit.edu	37	X	80047410	80047410	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chrX:80047410G>A	ENST00000373275.4	-	6	589	c.373C>T	c.(373-375)Ctg>Ttg	p.L125L		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	125										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CCTCTATGCAGAGCCGCAAAA	0.373000													4	17					0	0	0.248553	0	0
CEP72	55722	broad.mit.edu	37	5	639251	639251	+	Silent	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr5:639251G>T	ENST00000264935.5	+	8	1344	c.1254G>T	c.(1252-1254)ctG>ctT	p.L418L	CEP72_ENST00000444221.1_3'UTR	NM_018140.3	NP_060610.2	Q9P209	CEP72_HUMAN	centrosomal protein 72kDa	418					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(5)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	20			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			AGACGGCCCTGCAGGCGGCGC	0.632000													19	53					1.67942e-08	2.09927e-08	0.539581	1	0
AFF2	2334	broad.mit.edu	37	X	148055037	148055037	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chrX:148055037G>T	ENST00000370460.2	+	16	3783	c.3304G>T	c.(3304-3306)Gcc>Tcc	p.A1102S	AFF2_ENST00000286437.5_Missense_Mutation_p.A743S|AFF2_ENST00000370457.5_Missense_Mutation_p.A1067S|AFF2_ENST00000342251.3_Missense_Mutation_p.A1069S	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	1102					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					TTATGCTGATGCCGCCCTCTC	0.468000													20	48					2.37509e-13	3.49278e-13	0.592651	1	0
SLC36A4	120103	broad.mit.edu	37	11	92881884	92881884	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr11:92881884T>C	ENST00000326402.4	-	11	1464	c.1334A>G	c.(1333-1335)tAt>tGt	p.Y445C	SLC36A4_ENST00000529184.1_Missense_Mutation_p.Y310C	NM_152313.2	NP_689526.2	Q6YBV0	S36A4_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 4	445					L-alanine transport|proline transport|tryptophan transport	integral to membrane	symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	25		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				CCATATATTATAATGTTCCTT	0.358000													13	25					0	0	0.479597	0	0
CUL1	8454	broad.mit.edu	37	7	148497609	148497609	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:148497609C>G	ENST00000325222.4	+	22	2545	c.2266C>G	c.(2266-2268)Cta>Gta	p.L756V	CUL1_ENST00000602748.1_Missense_Mutation_p.L756V|CUL1_ENST00000409469.1_Missense_Mutation_p.L756V	NM_003592.2	NP_003583.2	Q13616	CUL1_HUMAN	cullin 1	756					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(10)|liver(2)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	40	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			CATTGACATTCTAATTGAGAA	0.428000													9	32					0	0	0.307466	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617548	77617548	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr8:77617548G>T	ENST00000521891.2	+	2	1673	c.1225G>T	c.(1225-1227)Ggg>Tgg	p.G409W	ZFHX4_ENST00000518282.1_Missense_Mutation_p.G409W|ZFHX4_ENST00000050961.6_Missense_Mutation_p.G409W|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000455469.2_Missense_Mutation_p.G409W	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	409						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGTGAATCTGGGGGGGCTGTC	0.537000										HNSCC(33;0.089)			7	15					0.0293803	0.0306045	0.248553	1	0
PKD1L1	168507	broad.mit.edu	37	7	47882684	47882684	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:47882684A>G	ENST00000289672.2	-	34	5371	c.5321T>C	c.(5320-5322)gTa>gCa	p.V1774A		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1774					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						ATGATGATCTACTTGTCTACT	0.413000													6	23					0	0	0.248553	0	0
EXTL1	2134	broad.mit.edu	37	1	26357639	26357639	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:26357639T>G	ENST00000374280.3	+	5	1985	c.1118T>G	c.(1117-1119)aTt>aGt	p.I373S	EXTL1_ENST00000484339.1_3'UTR	NM_004455.2	NP_004446.2	Q92935	EXTL1_HUMAN	exostosin-like glycosyltransferase 1	373					skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|stomach(1)|urinary_tract(1)	23		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGACCGGATTTTTGGAACA	0.587000													21	92					0	0	0.624587	0	0
TTI1	9675	broad.mit.edu	37	20	36641109	36641109	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr20:36641109G>A	ENST00000373448.2	-	3	1348	c.1110C>T	c.(1108-1110)ctC>ctT	p.L370L	TTI1_ENST00000449821.1_Silent_p.L370L|TTI1_ENST00000487362.1_Intron|TTI1_ENST00000373447.3_Silent_p.L370L	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	370							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AGATGTCAGCGAGGGCTTTGT	0.458000													15	136					0	0	0.592651	0	0
FTSJ2	29960	broad.mit.edu	37	7	2279318	2279318	+	Silent	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:2279318G>A	ENST00000440306.2	-	2	68	c.33C>T	c.(31-33)tcC>tcT	p.S11S	FTSJ2_ENST00000486040.1_5'UTR|FTSJ2_ENST00000242257.8_Silent_p.S11S			Q9UI43	RRMJ2_HUMAN	FtsJ RNA methyltransferase homolog 2 (E. coli)	11					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		GACGCTGAAAGGAAACACACA	0.577000													13	86					0	0	0.539581	0	0
EGFR	1956	broad.mit.edu	37	7	55242490	55242490	+	Missense_Mutation	SNP	A	A	G	rs121913463		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:55242490A>G	ENST00000275493.2	+	19	2437	c.2260A>G	c.(2260-2262)Aaa>Gaa	p.K754E	EGFR_ENST00000455089.1_Missense_Mutation_p.K709E|EGFR_ENST00000442591.1_Intron|EGFR_ENST00000454757.2_Missense_Mutation_p.K701E	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	754	Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.S752_I759del(13)|p.T751_I759>N(8)|p.T751_I759>S(3)|p.T751_I759del(2)|p.A750_E758>P(2)|p.L747_K754del(2)|p.K754E(2)|p.L747_K754>ST(1)|p.K754A(1)|p.A750_E758del(1)|p.T751_I759>REA(1)|p.A750_K754del(1)|p.T751_E758del(1)|p.L747_K754>N(1)|p.P753_I759del(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	AACATCTCCGAAAGCCAACAA	0.493000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			9	34					0	0	0.335167	0	0
DLG3	1741	broad.mit.edu	37	X	69719800	69719800	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chrX:69719800G>A	ENST00000194900.4	+	18	2483	c.2142G>A	c.(2140-2142)atG>atA	p.M714I	DLG3_ENST00000461646.1_3'UTR|DLG3_ENST00000374355.3_Missense_Mutation_p.M377I|DLG3_ENST00000542398.1_Missense_Mutation_p.M231I|DLG3_ENST00000374360.3_Missense_Mutation_p.M682I			Q92796	DLG3_HUMAN	discs, large homolog 3 (Drosophila)	682	Guanylate kinase-like.				axon guidance|negative regulation of cell proliferation|synaptic transmission	plasma membrane	guanylate kinase activity			endometrium(4)|kidney(1)|large_intestine(10)|lung(5)|pancreas(1)|urinary_tract(1)	22	Renal(35;0.156)					GAGAACAAATGGAGAAAGATA	0.488000													5	26					0	0	0.184627	0	0
GTF3C4	9329	broad.mit.edu	37	9	135553884	135553884	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr9:135553884C>T	ENST00000372146.4	+	2	1442	c.878C>T	c.(877-879)cCg>cTg	p.P293L	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	293					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		TTTCAGCTGCCGTTTGTAGGA	0.473000													6	50					0	0	0.217242	0	0
ZDBF2	57683	broad.mit.edu	37	2	207170309	207170309	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr2:207170309T>C	ENST00000374423.3	+	5	1443	c.1057T>C	c.(1057-1059)Ttt>Ctt	p.F353L		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	353							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						CAAGACAGCCTTTTGGGAACA	0.388000													11	39					0	0	0.411799	0	0
NBPF14	25832	broad.mit.edu	37	1	148009403	148009403	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:148009403T>C	ENST00000369219.1	-	16	1920	c.1904A>G	c.(1903-1905)tAc>tGc	p.Y635C				Q5TI25	NBPFE_HUMAN	neuroblastoma breakpoint family, member 14	635	NBPF 7.					cytoplasm				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(23)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	42	all_hematologic(923;0.032)					GGCACTTCTGTAGGGCTGGCA	0.468000													31	341					0	0	0.796494	0	0
ITGA1	3672	broad.mit.edu	37	5	52235460	52235460	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr5:52235460G>A	ENST00000282588.6	+	25	3577	c.3119G>A	c.(3118-3120)aGt>aAt	p.S1040N	CTD-2175A23.1_ENST00000505701.1_RNA|CTD-2175A23.1_ENST00000503559.1_RNA	NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	1040					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				GATCCTTTCAGTATCAACTCT	0.358000													5	20					0	0	0.217242	0	0
BIRC8	112401	broad.mit.edu	37	19	53793270	53793270	+	Missense_Mutation	SNP	G	G	C	rs113838023	byFrequency	TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr19:53793270G>C	ENST00000426466.1	-	1	1605	c.358C>G	c.(358-360)Cga>Gga	p.R120G		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	120					apoptosis		zinc ion binding	p.R120*(1)		NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		AATCCCATTCGTATAGCTTCT	0.383000													16	81					0	0	0.479597	0	0
NCOR1	9611	broad.mit.edu	37	17	16024509	16024509	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:16024509C>A	ENST00000268712.3	-	16	1966	c.1709G>T	c.(1708-1710)cGg>cTg	p.R570L	NCOR1_ENST00000583226.1_5'UTR|NCOR1_ENST00000395851.1_Missense_Mutation_p.R570L|NCOR1_ENST00000395848.1_Missense_Mutation_p.R461L	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	570					cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTTTCGCCCCCGGGGTGTGGC	0.537000													32	84					9.65963e-10	1.2937e-09	0.779181	1	0
TNK2	10188	broad.mit.edu	37	3	195593860	195593860	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr3:195593860G>A	ENST00000333602.6	-	14	3627	c.3010C>T	c.(3010-3012)Cgg>Tgg	p.R1004W	TNK2_ENST00000428187.1_Missense_Mutation_p.R1006W|TNK2_ENST00000392400.1_Missense_Mutation_p.R1004W|TNK2_ENST00000381916.2_Missense_Mutation_p.R1052W	NM_005781.4	NP_005772.3	Q07912	ACK1_HUMAN	tyrosine kinase, non-receptor, 2	1004				Missing (in Ref. 4; AAH08884).	positive regulation of peptidyl-tyrosine phosphorylation|protein ubiquitination|small GTPase mediated signal transduction	adherens junction|cytoplasmic vesicle membrane|endosome|nucleus	ATP binding|GTPase inhibitor activity|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|ovary(3)|prostate(4)|skin(2)|stomach(1)|urinary_tract(1)	29	all_cancers(143;6.48e-09)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;1.46e-22)|OV - Ovarian serous cystadenocarcinoma(49;8.3e-19)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;0.000757)	Adenosine triphosphate(DB00171)	CCTCTGGGCCGCAGACCCAGC	0.682000													3	30					0	0	0.115264	0	0
SCFD2	152579	broad.mit.edu	37	4	53786890	53786890	+	Splice_Site	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:53786890G>A	ENST00000401642.3	-	6	1841		c.e6+1		SCFD2_ENST00000388940.4_Splice_Site	NM_152540.3	NP_689753.2	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2						protein transport|vesicle docking involved in exocytosis					breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	30			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			GTATATACTTGCCTGGTGGGT	0.393000													6	46					0	0	0.217242	0	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29977342	29977342	+	RNA	SNP	A	A	T	rs116382006	by1000genomes	TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr6:29977342A>T	ENST00000376797.3	-	0	731				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							TGGGACTGAGAGGCAAGATTT	0.438000													3	53					0	0	0.150653	0	0
SNX8	29886	broad.mit.edu	37	7	2309240	2309240	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:2309240C>A	ENST00000222990.3	-	5	617	c.575G>T	c.(574-576)tGc>tTc	p.C192F		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	192					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		GTCCCCGACGCACTGTGCTGA	0.393000													7	28					1.26484e-09	1.66427e-09	0.278610	1	0
HLA-A	3105	broad.mit.edu	37	6	29910607	29910607	+	Silent	SNP	G	G	C	rs72555397		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr6:29910607G>C	ENST00000396634.1	+	4	488	c.147G>C	c.(145-147)gtG>gtC	p.V49V	HLA-A_ENST00000376806.5_Silent_p.V49V|HLA-A_ENST00000376809.5_Silent_p.V49V|HLA-A_ENST00000376802.2_Silent_p.V49V			P30443	1A01_HUMAN	major histocompatibility complex, class I, A	49	Alpha-1.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to plasma membrane|MHC class I protein complex	MHC class I receptor activity	p.V49V(2)		central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	30						TCATCGCCGTGGGCTACGTGG	0.692000									Osteosarcoma, Familial Clustering of;Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of;Melanoma, Familial Clustering of;Lichen Sclerosis et Atrophicus, Familial Clustering of	Multiple Myeloma(9;0.094)			8	32					0	0	0.307466	0	0
KIAA1109	84162	broad.mit.edu	37	4	123192663	123192663	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:123192663G>A	ENST00000264501.4	+	47	8357	c.7984G>A	c.(7984-7986)Gaa>Aaa	p.E2662K	KIAA1109_ENST00000388738.3_Missense_Mutation_p.E2662K|KIAA1109_ENST00000455637.1_Missense_Mutation_p.E2662K			Q2LD37	K1109_HUMAN	KIAA1109	2662					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AGGAAGATCTGAAAGAAGAAC	0.348000													3	19					0	0	0.115264	0	0
CDHR2	54825	broad.mit.edu	37	5	176019778	176019778	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr5:176019778C>G	ENST00000510636.1	+	31	4063	c.3789C>G	c.(3787-3789)atC>atG	p.I1263M	CDHR2_ENST00000261944.5_Missense_Mutation_p.I1263M|CDHR2_ENST00000506348.1_Missense_Mutation_p.I1263M	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	1263					homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GTCAGGAAATCAAGGCAAGAT	0.552000													23	53					0	0	0.706142	0	0
ELF3	1999	broad.mit.edu	37	1	201983060	201983060	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:201983060delC	ENST00000359651.3	+	7	4101	c.909delC	c.(907-909)ttfs	p.F303fs	ELF3_ENST00000367283.3_Frame_Shift_Del_p.F303fs|ELF3_ENST00000367284.5_Frame_Shift_Del_p.F303fs|RP11-510N19.5_ENST00000504773.1_RNA			P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription factor, epithelial-specific )	303					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	20						AAGGCGTCTTCAAGTTCCTGC	0.582													11	20	---	---	---	---					
OBSCN	84033	broad.mit.edu	37	1	228560034	228560034	+	Frame_Shift_Del	DEL	C	C	-	rs36119328	by1000genomes	TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr1:228560034delC	ENST00000570156.2	+	105	24500	c.24426delC	c.(24424-24426)tafs	p.Y8142fs	OBSCN_ENST00000422127.1_Frame_Shift_Del_p.Y7185fs|OBSCN_ENST00000366707.4_Frame_Shift_Del_p.Y4819fs	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	7185					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GCGGGGGCTACGCAGGCGTGG	0.667													5	4	---	---	---	---					
TADA2B	93624	broad.mit.edu	37	4	7056195	7056196	+	Frame_Shift_Ins	INS	-	-	C	rs75397160		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr4:7056195_7056196insC	ENST00000310074.7	+	2	866_867	c.677_678insC	c.(676-678)taafs	p.*226fs	TADA2B_ENST00000512388.1_Frame_Shift_Ins_p.*151fs|TADA2B_ENST00000515646.1_Frame_Shift_Ins_p.*134fs	NM_152293.2	NP_689506.2	Q86TJ2	TAD2B_HUMAN	transcriptional adaptor 2B	226					regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|zinc ion binding	p.Y226*(1)		breast(3)|endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)	18						GCCCGTGACTACAATCTGGTGC	0.579													31	105	---	---	---	---					
DND1	373863	broad.mit.edu	37	5	140052285	140052285	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr5:140052285delT	ENST00000542735.1	-	3	392	c.349delA	c.(349-351)cgfs	p.T117fs		NM_194249.2	NP_919225.1	Q8IYX4	DND1_HUMAN	DND microRNA-mediated repression inhibitor 1	117	RRM 1.				multicellular organismal development|negative regulation of gene silencing by miRNA	cytoplasm|nucleus	AU-rich element binding|nucleotide binding	p.T117fs*24(1)		central_nervous_system(1)|prostate(4)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGTGCAGCGTGGCGATGGCG	0.682													5	4	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55242466	55242474	+	In_Frame_Del	DEL	GAATTAAGA	GAATTAAGA	-	rs121913438		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr7:55242466_55242474delGAATTAAGA	ENST00000275493.2	+	19	2413_2421	c.2236_2244delGAATTAAGA	c.(2236-2244)del	p.ELR746del	EGFR_ENST00000454757.2_In_Frame_Del_p.ELR693del|EGFR_ENST00000455089.1_In_Frame_Del_p.ELR701del|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	746	Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1007)|p.L747_P753>S(123)|p.L747_A750>P(82)|p.L747_T751del(76)|p.E746_S752>V(57)|p.L747_S752del(34)|p.L747_T751>P(21)|p.E746_T751>A(21)|p.L747_E749del(16)|p.E746_E749del(9)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.K745_E749del(6)|p.E746_T751>V(6)|p.L747S(6)|p.E746_S752>A(6)|p.E746_T751>VA(6)|p.L747_T751>Q(5)|p.E746_T751del(4)|p.E746_T751>I(4)|p.E746_S752>D(4)|p.E746_S752>I(4)|p.K745_E746insVPVAIK(4)|p.E746_A750>IP(3)|p.L747P(3)|p.L747_S752>Q(3)|p.E746K(3)|p.E746_T751>IP(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.L747_S752>QH(2)|p.E746_S752del(2)|p.E746_P753>VS(2)|p.E746_A750>QP(2)|p.L747_K754del(2)|p.L747_K754>ST(1)|p.E746_A750>VP(1)|p.L747_P753del(1)|p.E746del(1)|p.L747_K754>N(1)|p.E746_P753>IS(1)|p.E746_T751>L(1)|p.L747_R748>FP(1)|p.L747_T751>A(1)|p.I744_E749>LKR(1)|p.E746_P753>LS(1)|p.E746_T751>Q(1)|p.E746_T751>S(1)|p.E746_P753>VQ(1)|p.E746_A750>DP(1)|p.E746V(1)|p.I744_A750>VK(1)|p.R748I(1)|p.K745_A750del(1)|p.R748K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCTATCAAGGAATTAAGAGAAGCAACAT	0.478	E746K(HCC827_LUNG)|E746_A750del(NCIH1650_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			11	50	---	---	---	---					
LGALS9B	284194	broad.mit.edu	37	17	20370782	20370783	+	Translation_Start_Site	INS	-	-	TC	rs147679570		TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr17:20370782_20370783insTC	ENST00000423676.3	-	0	64_65				LGALS9B_ENST00000324290.5_Start_Codon_Ins			Q3B8N2	LEG9B_HUMAN	lectin, galactoside-binding, soluble, 9B								sugar binding	p.M1fs*12(1)		central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	10						GCTGAAGGCCATCTCCACCGCC	0.584													3	6	---	---	---	---					
DUXA	503835	broad.mit.edu	37	19	57666695	57666695	+	Frame_Shift_Del	DEL	T	T	-			TCGA-55-7573-01A-11D-2036-08	TCGA-55-7573-11A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	36b5181b-9b59-428a-9c0e-45ac9e0d1674	4cc8017b-3238-4cf0-9c04-4a739fe7b511	g.chr19:57666695delT	ENST00000554048.2	-	5	483	c.484delA	c.(484-486)ggfs	p.R162fs		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	162						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		ACAGGTTCCCTTTTTCTCTGG	0.408													7	54	---	---	---	---					
