Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
BLID	414899	broad.mit.edu	37	11	121986579	121986579	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:121986579G>T	ENST00000560104.1	-	1	344	c.52C>A	c.(52-54)Cta>Ata	p.L18I		NM_001001786.2	NP_001001786.2	Q8IZY5	BLID_HUMAN	BH3-like motif containing, cell death inducer	18					apoptosis	mitochondrion				NS(1)|large_intestine(4)|lung(6)|pancreas(1)	12		Breast(109;0.0164)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;2.08e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.101)		TCAGATTCTAGGATCTCAAAG	0.448000											OREG0021435	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	35	18					3.38236e-24	5.73844e-24	1	1	0
CSMD1	64478	broad.mit.edu	37	8	2910079	2910079	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:2910079T>A	ENST00000520002.1	-	51	8123	c.7568A>T	c.(7567-7569)cAt>cTt	p.H2523L	CSMD1_ENST00000542608.1_Missense_Mutation_p.H2522L|CSMD1_ENST00000537824.1_Missense_Mutation_p.H2522L|CSMD1_ENST00000602723.1_Missense_Mutation_p.H2523L|CSMD1_ENST00000400186.3_Missense_Mutation_p.H2523L|CSMD1_ENST00000602557.1_Missense_Mutation_p.H2523L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2523	Sushi 15.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GAAGCCCTCATGACATTCATA	0.498000													3	10					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158507936	158507936	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:158507936G>T	ENST00000355585.4	+	23	3333	c.3258G>T	c.(3256-3258)gaG>gaT	p.E1086D	SYNJ2_ENST00000367122.2_Intron|SYNJ2_ENST00000367112.1_Missense_Mutation_p.E171D|SYNJ2_ENST00000367121.3_Missense_Mutation_p.E1086D	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	1086							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		CCGTCGGGGAGTTCCGCCACC	0.647000													19	33					6.49762e-13	9.17991e-13	1	1	0
CES3	23491	broad.mit.edu	37	16	66998614	66998614	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:66998614C>T	ENST00000303334.4	+	6	874	c.803C>T	c.(802-804)cCt>cTt	p.P268L	CES3_ENST00000394037.1_Missense_Mutation_p.P268L	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	268						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GACTCTCACCCTTGGCCCCTA	0.597000													43	75					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122418716	122418716	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:122418716T>G	ENST00000474629.2	+	6	1581	c.1315T>G	c.(1315-1317)Tca>Gca	p.S439A		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	439					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		AGCAGGGAAATCAGAGGATGT	0.363000													22	40					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61985470	61985470	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr13:61985470C>A	ENST00000409186.1	-	5	4867	c.2762G>T	c.(2761-2763)aGg>aTg	p.R921M	PCDH20_ENST00000409204.4_Missense_Mutation_p.R921M			Q8N6Y1	PCD20_HUMAN	protocadherin 20	894					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TTCATCTTCCCTGGGATGCTT	0.403000													12	25					0.000151284	0.000165911	1	1	0
C8A	731	broad.mit.edu	37	1	57347210	57347210	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:57347210G>T	ENST00000361249.3	+	5	653	c.557G>T	c.(556-558)aGg>aTg	p.R186M		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	186	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						GGGGAATGGAGGGAGCTTCGA	0.458000													20	74					3.62473e-10	4.70268e-10	1	1	0
ZNF711	7552	broad.mit.edu	37	X	84520160	84520160	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:84520160G>A	ENST00000360700.4	+	6	1701	c.815G>A	c.(814-816)aGt>aAt	p.S272N	ZNF711_ENST00000373165.3_Missense_Mutation_p.S272N|ZNF711_ENST00000542798.1_Missense_Mutation_p.S68N|ZNF711_ENST00000276123.3_Missense_Mutation_p.S272N|ZNF711_ENST00000395402.1_Missense_Mutation_p.S250N			Q9Y462	ZN711_HUMAN	zinc finger protein 711	272					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GAGTACACCAGTGGACATTCA	0.388000													51	75					0	0	1	0	0
IFT74	80173	broad.mit.edu	37	9	26978150	26978150	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:26978150G>A	ENST00000443698.1	+	3	316	c.145G>A	c.(145-147)Ggt>Agt	p.G49S	IFT74_ENST00000380062.5_Missense_Mutation_p.G49S|IFT74_ENST00000433700.1_Missense_Mutation_p.G49S|IFT74_ENST00000429045.2_Missense_Mutation_p.G49S	NM_001099222.1	NP_001092692.1	Q96LB3	IFT74_HUMAN	intraflagellar transport 74 homolog (Chlamydomonas)	49						cytoplasmic membrane-bounded vesicle|intraflagellar transport particle B|microtubule-based flagellum				endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)	6		all_neural(11;2.36e-10)		Lung(218;1.4e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		AGCAAGACCAGGTTCTCGTGG	0.408000													9	25					0	0	1	0	0
IGHV1-24	28467	broad.mit.edu	37	14	106733189	106733189	+	RNA	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:106733189C>A	ENST00000390610.2	-	0	365																											TCAGGCTGCTCAGCTCCATGT	0.512000													52	215					1.64573e-32	2.8656e-32	1	1	0
PRDX4	10549	broad.mit.edu	37	X	23685897	23685897	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:23685897C>A	ENST00000379341.4	+	1	335	c.210C>A	c.(208-210)gcC>gcA	p.A70A	PRDX4_ENST00000495599.1_3'UTR|PRDX4_ENST00000379331.3_Silent_p.A70A	NM_006406.1	NP_006397.1	Q13162	PRDX4_HUMAN	peroxiredoxin 4	70					cell redox homeostasis|I-kappaB phosphorylation		thioredoxin peroxidase activity			lung(6)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	9						TATCGGTCGCCGACCACTCCC	0.642000													39	23					7.66079e-34	1.3517e-33	1	1	0
SLC38A8	146167	broad.mit.edu	37	16	84070480	84070480	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:84070480C>T	ENST00000299709.3	-	2	214	c.215G>A	c.(214-216)gGg>gAg	p.G72E		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	72					amino acid transport|sodium ion transport	integral to membrane		p.G72V(1)		central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						GATGACCAGCCCGCTGATCAG	0.662000													9	8					0	0	1	0	0
SNRK	54861	broad.mit.edu	37	3	43389307	43389307	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:43389307C>T	ENST00000296088.7	+	7	1860	c.1556C>T	c.(1555-1557)cCa>cTa	p.P519L	SNRK_ENST00000429705.2_Missense_Mutation_p.P519L|SNRK_ENST00000437827.1_Missense_Mutation_p.P313L|SNRK_ENST00000454177.1_Missense_Mutation_p.P519L	NM_017719.4	NP_060189.3	Q9NRH2	SNRK_HUMAN	SNF related kinase	519					myeloid cell differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(3)|ovary(5)|prostate(1)|skin(2)|stomach(1)	27				KIRC - Kidney renal clear cell carcinoma(284;0.0636)|Kidney(284;0.0792)		ATAGCTTCTCCAGGTACAGTT	0.507000													13	24					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79319005	79319005	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:79319005C>A	ENST00000428286.1	-	9	7647	c.6447G>T	c.(6445-6447)aaG>aaT	p.K2149N	PRUNE2_ENST00000376718.3_Missense_Mutation_p.K2508N			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2508					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						CTGATATTTCCTTGCTGGCAC	0.353000													8	33					0.000978159	0.00104671	1	1	0
HPSE2	60495	broad.mit.edu	37	10	100995547	100995547	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr10:100995547A>T	ENST00000370552.3	-	1	72	c.13T>A	c.(13-15)Tgt>Agt	p.C5S	HPSE2_ENST00000370546.1_Missense_Mutation_p.C5S|HPSE2_ENST00000370549.1_Missense_Mutation_p.C5S|HPSE2_ENST00000404542.1_Missense_Mutation_p.C5S	NM_021828.4	NP_068600.4	Q8WWQ2	HPSE2_HUMAN	heparanase 2	5					carbohydrate metabolic process	intracellular|membrane	cation binding|heparanase activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	40				Epithelial(162;1.8e-09)|all cancers(201;4.72e-07)		GGGAAGGCACAAAGCACCCTC	0.547000													21	40					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50765651	50765651	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:50765651G>T	ENST00000404971.1	-	11	3342	c.2003C>A	c.(2002-2004)cCc>cAc	p.P668H	NRXN1_ENST00000406859.3_Missense_Mutation_p.P628H|NRXN1_ENST00000402717.3_Missense_Mutation_p.P620H|NRXN1_ENST00000401669.2_Missense_Mutation_p.P628H|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406316.2_Missense_Mutation_p.P628H|NRXN1_ENST00000405472.3_Missense_Mutation_p.P620H	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	628	Laminin G-like 3.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.P668H(1)|p.P628H(1)|p.P669H(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CACCTCGGTGGGGAAGACAAG	0.532000													20	125					3.62473e-10	4.70268e-10	1	1	0
IL9R	3581	broad.mit.edu	37	X	155233195	155233195	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:155233195A>T	ENST00000424344.3	+	4	528	c.161A>T	c.(160-162)cAg>cTg	p.Q54L	IL9R_ENST00000540897.1_Missense_Mutation_p.Q112L|IL9R_ENST00000244174.5_Missense_Mutation_p.Q75L|IL9R_ENST00000369423.2_Missense_Mutation_p.Q122L			Q01113	IL9R_HUMAN	interleukin 9 receptor	75					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity			NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GAGCTGGGACAGGGCTCCAGC	0.592000													12	40					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87027794	87027794	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:87027794C>A	ENST00000398399.2	-	2	648	c.285G>T	c.(283-285)caG>caT	p.Q95H	VGLL3_ENST00000383698.3_Missense_Mutation_p.Q95H	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		CAATGTCTCCCTGGAAATAAG	0.507000													14	17					7.93312e-07	9.37336e-07	1	1	0
BCOR	54880	broad.mit.edu	37	X	39930369	39930369	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:39930369T>A	ENST00000342274.4	-	6	3457	c.3095A>T	c.(3094-3096)gAa>gTa	p.E1032V	BCOR_ENST00000397354.3_Missense_Mutation_p.E1032V|BCOR_ENST00000378455.4_Missense_Mutation_p.E1014V|BCOR_ENST00000378444.4_Missense_Mutation_p.E1032V	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	1032					heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						GTGGCCACCTTCTCTTTCTTT	0.448000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						14	16					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17202591	17202591	+	Silent	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:17202591C>T	ENST00000261381.6	-	12	2925	c.2841G>A	c.(2839-2841)tcG>tcA	p.S947S		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	947					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CCCCCAGCTCCGACTTGGGGT	0.652000													6	29					0	0	1	0	0
TBX22	50945	broad.mit.edu	37	X	79282217	79282217	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:79282217C>A	ENST00000442340.1	+	6	778	c.288C>A	c.(286-288)tcC>tcA	p.S96S	TBX22_ENST00000373291.1_Silent_p.S96S|TBX22_ENST00000373294.5_Silent_p.S216S|TBX22_ENST00000373296.3_Silent_p.S216S	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	216					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TTCTGCAATCCATGCATAAGT	0.483000													75	75					1.16668e-32	2.0404e-32	1	1	0
IGFALS	3483	broad.mit.edu	37	16	1841461	1841461	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:1841461G>A	ENST00000415638.3	-	2	1151	c.1072C>T	c.(1072-1074)Cag>Tag	p.Q358*	IGFALS_ENST00000215539.3_Nonsense_Mutation_p.Q320*	NM_001146006.1|NM_004970.2	NP_001139478.1|NP_004961.1	P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	320					cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						TGGCCCAGCTGCAGCTCCTCC	0.677000													11	13					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105906085	105906085	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr10:105906085C>T	ENST00000357060.3	-	30	3906	c.3791G>A	c.(3790-3792)cGg>cAg	p.R1264Q	WDR96_ENST00000428666.1_Intron	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1264										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCTAGATTTCCGAACAGCTTC	0.408000													17	40					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197062287	197062287	+	Silent	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:197062287T>A	ENST00000367409.4	-	21	9445	c.9189A>T	c.(9187-9189)atA>atT	p.I3063I	ASPM_ENST00000294732.7_Silent_p.I1478I|ASPM_ENST00000367408.1_Silent_p.I728I	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3063					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						CCCTGGCTCGTATATATTTTT	0.393000													22	55					0	0	1	0	0
HOMEZ	57594	broad.mit.edu	37	14	23745473	23745473	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:23745473C>A	ENST00000357460.5	-	2	1128	c.964G>T	c.(964-966)Gca>Tca	p.A322S	HOMEZ_ENST00000561013.1_Missense_Mutation_p.A324S|HOMEZ_ENST00000431326.2_Missense_Mutation_p.A324S	NM_020834.2	NP_065885.2	Q8IX15	HOMEZ_HUMAN	homeobox and leucine zipper encoding	322						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(5)|lung(7)	12	all_cancers(95;5.54e-06)			GBM - Glioblastoma multiforme(265;0.00643)		GGGGGTAATGCCTGTTCACTG	0.557000													40	28					9.62906e-15	1.45351e-14	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113988224	113988224	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:113988224C>A	ENST00000297405.5	-	7	1428	c.1184G>T	c.(1183-1185)cGa>cTa	p.R395L	CSMD3_ENST00000343508.3_Missense_Mutation_p.R355L|CSMD3_ENST00000352409.3_Missense_Mutation_p.R395L|CSMD3_ENST00000455883.2_Intron	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	395						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AACTTGCACTCGCTGTTCCTC	0.502000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			18	66					4.63292e-17	7.18465e-17	1	1	0
ZCCHC14	23174	broad.mit.edu	37	16	87493625	87493625	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:87493625T>A	ENST00000268616.4	-	2	489	c.272A>T	c.(271-273)aAa>aTa	p.K91I		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	91					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		TTTGCTGTGTTTTCCTAAGGG	0.557000													49	234					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94655614	94655614	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:94655614T>C	ENST00000260526.6	-	13	1489	c.1307A>G	c.(1306-1308)cAg>cGg	p.Q436R	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	436					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		CTGCAGATGCTGCATGTGGAA	0.428000													9	18					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117299113	117299113	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:117299113G>T	ENST00000321322.6	-	33	6274	c.6273C>A	c.(6271-6273)agC>agA	p.S2091R	DSCAML1_ENST00000527706.1_Missense_Mutation_p.S1821R	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	2031					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCCCCGATGTGCTCATCTCGA	0.692000													51	31					7.34454e-26	1.2568e-25	1	1	0
GRIN1	2902	broad.mit.edu	37	9	140056880	140056880	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:140056880C>A	ENST00000371561.3	+	13	2873	c.1776C>A	c.(1774-1776)aaC>aaA	p.N592K	GRIN1_ENST00000371559.4_Missense_Mutation_p.N592K|GRIN1_ENST00000371550.4_Missense_Mutation_p.N592K|GRIN1_ENST00000371560.3_Missense_Mutation_p.N613K|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000371546.4_Missense_Mutation_p.N613K|GRIN1_ENST00000371553.3_Missense_Mutation_p.N613K|GRIN1_ENST00000371555.4_Missense_Mutation_p.N613K|GRIN1_ENST00000315048.3_Missense_Mutation_p.N592K|GRIN1_ENST00000350902.5_Missense_Mutation_p.N592K	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	592					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	TCAAGGTGAACAGCGAGGAGG	0.736000													9	18					3.07112e-06	3.54428e-06	1	1	0
CLLU1OS	574016	broad.mit.edu	37	12	92816356	92816356	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:92816356C>G	ENST00000378487.2	-	2	110	c.109G>C	c.(109-111)Gca>Cca	p.A37P	CLLU1OS_ENST00000538965.1_Missense_Mutation_p.A37P|CLLU1_ENST00000472839.2_Intron|RP11-693J15.4_ENST00000508671.1_RNA	NM_001025232.1	NP_001020403.1	Q5K130	CLU1O_HUMAN	chronic lymphocytic leukemia up-regulated 1 opposite strand	37										large_intestine(1)|lung(7)	8						gccccaagtgcagggccatag	0.398000													6	9					0	0	1	0	0
KIF7	374654	broad.mit.edu	37	15	90172673	90172673	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:90172673G>T	ENST00000394412.3	-	17	3526	c.3450C>A	c.(3448-3450)gaC>gaA	p.D1150E		NM_198525.2	NP_940927.2	Q2M1P5	KIF7_HUMAN	kinesin family member 7	1150					microtubule-based movement|negative regulation of smoothened signaling pathway|positive regulation of smoothened signaling pathway	cilium	ATP binding|microtubule motor activity|protein binding			central_nervous_system(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|stomach(1)|urinary_tract(1)	25	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			TCAGCTGGCGGTCCATCTCCA	0.647000													37	82					3.76114e-14	5.61342e-14	1	1	0
REM1	28954	broad.mit.edu	37	20	30070126	30070126	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:30070126G>T	ENST00000201979.2	+	4	753	c.460G>T	c.(460-462)Ggc>Tgc	p.G154C		NM_014012.4	NP_054731.2	O75628	REM1_HUMAN	RAS (RAD and GEM)-like GTP-binding 1	154					small GTPase mediated signal transduction	membrane	calmodulin binding|GTP binding|GTPase activity			kidney(3)|large_intestine(3)|lung(14)|pancreas(2)|upper_aerodigestive_tract(1)	23	all_cancers(5;0.000119)|Lung NSC(7;1.32e-05)|all_lung(7;2.14e-05)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Colorectal(19;0.00254)|COAD - Colon adenocarcinoma(19;0.0347)			CCTGCAGGGGGGCAGTGCCTA	0.597000													21	26					3.51602e-12	4.89775e-12	1	1	0
CSMD3	114788	broad.mit.edu	37	8	113516136	113516136	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:113516136C>A	ENST00000297405.5	-	30	5210	c.4966G>T	c.(4966-4968)Gga>Tga	p.G1656*	CSMD3_ENST00000343508.3_Nonsense_Mutation_p.G1616*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.G1656*|CSMD3_ENST00000455883.2_Nonsense_Mutation_p.G1552*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1656	CUB 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGAAAACTTCCAATCAGTGGG	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			7	35					0.27861	0.279314	1	1	0
PTHLH	5744	broad.mit.edu	37	12	28116374	28116374	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:28116374C>A	ENST00000535992.1	-	3	777	c.431G>T	c.(430-432)cGc>cTc	p.R144L	PTHLH_ENST00000538310.1_Missense_Mutation_p.R144L|PTHLH_ENST00000395872.1_Missense_Mutation_p.R144L|PTHLH_ENST00000201015.4_Missense_Mutation_p.R144L|PTHLH_ENST00000539239.1_Missense_Mutation_p.R144L|PTHLH_ENST00000354417.3_Missense_Mutation_p.R144L|PTHLH_ENST00000545234.1_Missense_Mutation_p.R144L|PTHLH_ENST00000395868.3_Missense_Mutation_p.R144L|RP11-993B23.3_ENST00000538113.1_RNA			P12272	PTHR_HUMAN	parathyroid hormone-like hormone	144					activation of adenylate cyclase activity by G-protein signaling pathway|cAMP metabolic process|cell-cell signaling|epidermis development|female pregnancy|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation	cytoplasm|extracellular space|nucleus	hormone activity|peptide hormone receptor binding			breast(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)|stomach(1)	10	Lung SC(9;0.184)					CCAGGCAGAGCGAGTTCGCCG	0.552000													33	22					3.62531e-18	5.78011e-18	1	1	0
GLRA4	441509	broad.mit.edu	37	X	102979908	102979908	+	Silent	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:102979908C>T	ENST00000372617.4	-	2	540	c.120G>A	c.(118-120)caG>caA	p.Q40Q		NM_001024452.2	NP_001019623.2	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4	40						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						GGGACATGGGCTGGGACCCCT	0.478000													4	17					0	0	1	0	0
TRIM8	81603	broad.mit.edu	37	10	104404540	104404540	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr10:104404540A>T	ENST00000302424.6	+	1	288	c.166A>T	c.(166-168)Aac>Tac	p.N56Y		NM_030912.2	NP_112174.2	Q9BZR9	TRIM8_HUMAN	tripartite motif containing 8	56						cytoplasm|PML body	ligase activity|protein homodimerization activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	15		Colorectal(252;0.122)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCCAGAGTGCAACCAGGCCTA	0.642000													6	6					0	0	1	0	0
BRSK1	84446	broad.mit.edu	37	19	55800959	55800959	+	Silent	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:55800959G>C	ENST00000309383.1	+	4	706	c.429G>C	c.(427-429)gcG>gcC	p.A143A	BRSK1_ENST00000585418.1_Silent_p.A143A|BRSK1_ENST00000590333.1_Silent_p.A159A	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	143	Protein kinase.				establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TTGTGTCTGCGCTGGACTTCT	0.617000													7	37					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33565445	33565445	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:33565445T>A	ENST00000321505.4	+	1	1625	c.1445T>A	c.(1444-1446)cTc>cAc	p.L482H	KIAA1549L_ENST00000265654.5_Missense_Mutation_p.L482H|KIAA1549L_ENST00000389726.3_Missense_Mutation_p.L482H					KIAA1549-like																		GATCTAGTCCTCGGTACAAGC	0.468000											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	45					0	0	1	0	0
MOSPD2	158747	broad.mit.edu	37	X	14915340	14915340	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:14915340G>T	ENST00000380492.3	+	5	545	c.457G>T	c.(457-459)Gaa>Taa	p.E153*	MOSPD2_ENST00000495110.1_3'UTR|MOSPD2_ENST00000482354.1_Nonsense_Mutation_p.E153*	NM_001177475.1|NM_152581.3	NP_001170946.1|NP_689794.1	Q8NHP6	MSPD2_HUMAN	motile sperm domain containing 2	153	CRAL-TRIO.					integral to membrane	structural molecule activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	Hepatocellular(33;0.183)					TGACCTGTCAGAAACTGGAAT	0.393000													18	91					2.98393e-07	3.56814e-07	1	1	0
DEF6	50619	broad.mit.edu	37	6	35280250	35280250	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:35280250C>T	ENST00000316637.5	+	4	600	c.595C>T	c.(595-597)Cgg>Tgg	p.R199W	DEF6_ENST00000542066.1_Intron	NM_022047.3	NP_071330.3	Q9H4E7	DEFI6_HUMAN	differentially expressed in FDCP 6 homolog (mouse)	199						cytoplasm|nucleus|plasma membrane				cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	15						GGGCGTGGGCCGGGACACCCT	0.652000													16	24					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34962304	34962304	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:34962304C>A	ENST00000329357.5	+	1	1392	c.1356C>A	c.(1354-1356)gaC>gaA	p.D452E		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	452										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GTGTTTCTGACTCTCTTCAAC	0.483000													27	136					1.06647e-15	1.62218e-15	1	1	0
XPNPEP2	7512	broad.mit.edu	37	X	128880265	128880265	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:128880265T>A	ENST00000371106.3	+	5	544	c.352T>A	c.(352-354)Tgg>Agg	p.W118R	XPNPEP2_ENST00000371105.3_Missense_Mutation_p.W118R	NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	118					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						CAGTCGCTACTGGACTCAGGC	0.557000													7	30					0	0	1	0	0
IGHV1-58	28464	broad.mit.edu	37	14	107078418	107078418	+	RNA	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:107078418C>A	ENST00000390628.2	-	0	366																											TCAGGCTGCTCAGCTCCATGT	0.537000													30	128					9.65021e-13	1.35856e-12	1	1	0
STK11IP	114790	broad.mit.edu	37	2	220473022	220473022	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:220473022G>T	ENST00000456909.1	+	14	1563	c.1473G>T	c.(1471-1473)agG>agT	p.R491S	STK11IP_ENST00000295641.10_Missense_Mutation_p.R502S			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	502	Glu-rich.				protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGGAGGTCAGGGCGGAGCCAC	0.637000													7	8					2.0095e-06	2.34638e-06	1	1	0
FN3KRP	79672	broad.mit.edu	37	17	80684407	80684407	+	Missense_Mutation	SNP	C	C	G	rs148824851		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:80684407C>G	ENST00000269373.6	+	5	593	c.520C>G	c.(520-522)Cag>Gag	p.Q174E	FN3KRP_ENST00000535965.1_Missense_Mutation_p.Q124E	NM_024619.3	NP_078895.2	Q9HA64	KT3K_HUMAN	fructosamine 3 kinase related protein	174							kinase activity			breast(1)|large_intestine(2)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	7	Breast(20;0.000523)|all_neural(118;0.0952)		BRCA - Breast invasive adenocarcinoma(99;0.0344)|OV - Ovarian serous cystadenocarcinoma(97;0.061)			GCAGCGCATTCAGCCCCAGAT	0.582000													37	153					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175046861	175046861	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:175046861G>T	ENST00000239462.4	+	2	420	c.307G>T	c.(307-309)Ggc>Tgc	p.G103C		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	103					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CGAGTTGGCAGGCAGTGTCCA	0.607000													14	45					2.23348e-06	2.60027e-06	1	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5303568	5303568	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:5303568G>T	ENST00000274181.7	+	19	3115	c.2977G>T	c.(2977-2979)Ggg>Tgg	p.G993W		NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	993	TSP type-1 4.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						ATGGAGCGCCGGGCCCTGGGC	0.662000													6	20					2.7689e-08	3.43516e-08	1	1	0
VCAN	1462	broad.mit.edu	37	5	82789654	82789654	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:82789654T>A	ENST00000265077.3	+	5	1217	c.652T>A	c.(652-654)Tat>Aat	p.Y218N	VCAN_ENST00000343200.5_Missense_Mutation_p.Y218N|VCAN_ENST00000512590.2_Missense_Mutation_p.Y170N|VCAN_ENST00000513984.1_Missense_Mutation_p.Y218N|VCAN_ENST00000342785.4_Missense_Mutation_p.Y218N|VCAN_ENST00000502527.2_Missense_Mutation_p.Y218N	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	218	Link 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		AGTAGGCTGTTATGGAGATAA	0.458000													26	22					0	0	1	0	0
OR51F2	119694	broad.mit.edu	37	11	4843362	4843362	+	Silent	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:4843362G>C	ENST00000322110.5	+	1	812	c.747G>C	c.(745-747)cgG>cgC	p.R249R	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	249					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		AAGAGAGGCGGAAAGCCTTCA	0.502000													9	40					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141092028	141092028	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:141092028G>T	ENST00000389484.3	-	79	13188	c.12217C>A	c.(12217-12219)Ccc>Acc	p.P4073T		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4073					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATACCTGTGGGTCTCTGTAAG	0.368000										TSP Lung(27;0.18)			9	36					1.58986e-06	1.86188e-06	1	1	0
MYT1L	23040	broad.mit.edu	37	2	1893073	1893073	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:1893073G>T	ENST00000399161.2	-	16	3207	c.2460C>A	c.(2458-2460)ccC>ccA	p.P820P	MYT1L_ENST00000428368.2_Silent_p.P818P	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	820					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TGTAGTCTACGGGCAAGTCCC	0.562000													30	54					1.04352e-10	1.39019e-10	1	1	0
KRT16	3868	broad.mit.edu	37	17	39767599	39767599	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:39767599C>A	ENST00000301653.4	-	3	833	c.769G>T	c.(769-771)Gag>Tag	p.E257*		NM_005557.3	NP_005548.2	P08779	K1C16_HUMAN	keratin 16	257	Coil 1B.|Rod.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		Breast(137;0.000307)				GACCGTACCTCCTCGTGGTTC	0.637000													39	28					5.78141e-17	8.93082e-17	1	1	0
ZNF195	7748	broad.mit.edu	37	11	3381717	3381717	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:3381717C>A	ENST00000354599.6	-	4	409	c.305G>T	c.(304-306)gGa>gTa	p.G102V	ZNF195_ENST00000005082.9_Missense_Mutation_p.G151V|ZNF195_ENST00000429541.2_Missense_Mutation_p.G106V|ZNF195_ENST00000399602.4_Missense_Mutation_p.G174V|ZNF195_ENST00000343338.7_Missense_Mutation_p.G106V|ZNF195_ENST00000526601.1_Missense_Mutation_p.G155V|ZNF195_ENST00000528796.1_Intron|ZNF195_ENST00000438262.2_3'UTR	NM_001242843.1|NM_001256825.1|NM_007152.4	NP_001229772.1|NP_001243754.1|NP_009083.2	O14628	ZN195_HUMAN	zinc finger protein 195	174	Spacer.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)	17		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTCCATATCCTCTCAGTAT	0.338000													10	36					2.74318e-10	3.61808e-10	1	1	0
HERC5	51191	broad.mit.edu	37	4	89408247	89408247	+	Missense_Mutation	SNP	G	G	A	rs148569726		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:89408247G>A	ENST00000264350.3	+	15	2032	c.1879G>A	c.(1879-1881)Gtc>Atc	p.V627I	HERC5_ENST00000508159.1_Missense_Mutation_p.V265I	NM_016323.3	NP_057407.2	Q9UII4	HERC5_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 5	627					innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity	p.V627I(1)		NS(2)|breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(11)|liver(2)|lung(17)|ovary(4)|prostate(1)|skin(4)	53		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		ACAATGCTGCGTCATATTCAG	0.318000													10	13					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43858093	43858093	+	RNA	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:43858093C>A	ENST00000378009.4	+	0	183				CD177_ENST00000378012.2_RNA|CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				CTAAGAACACCAGCTGCGACA	0.632000													18	35					3.62473e-10	4.70268e-10	1	1	0
IMPDH1	3614	broad.mit.edu	37	7	128035227	128035227	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:128035227C>A	ENST00000338791.6	-	13	1713	c.1363G>T	c.(1363-1365)Gtg>Ttg	p.V455L	IMPDH1_ENST00000470772.1_Missense_Mutation_p.V369L|IMPDH1_ENST00000480861.1_Missense_Mutation_p.V365L|IMPDH1_ENST00000496200.1_Missense_Mutation_p.V345L|IMPDH1_ENST00000343214.4_Missense_Mutation_p.V345L|IMPDH1_ENST00000348127.6_Missense_Mutation_p.V419L|IMPDH1_ENST00000378717.4_Missense_Mutation_p.V386L|IMPDH1_ENST00000419067.2_Missense_Mutation_p.V422L|IMPDH1_ENST00000354269.5_Missense_Mutation_p.V445L	NM_000883.3	NP_000874.2	P20839	IMDH1_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 1	370					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	DNA binding|IMP dehydrogenase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)	22					Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)|Ribavirin(DB00811)|Thioguanine(DB00352)	ACGTGTCCCACGGTCTGGATG	0.662000													27	30					3.73988e-18	5.91527e-18	1	1	0
OTUD6A	139562	broad.mit.edu	37	X	69283183	69283183	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:69283183A>T	ENST00000338352.2	+	1	843	c.809A>T	c.(808-810)aAc>aTc	p.N270I		NM_207320.1	NP_997203.1	Q7L8S5	OTU6A_HUMAN	OTU domain containing 6A	270	OTU.									autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(3)|urinary_tract(1)	23						GAGCACTACAACTCCGTGACA	0.677000													4	25					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152750	18152750	+	Silent	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:18152750C>T	ENST00000375406.1	+	3	1053	c.837C>T	c.(835-837)tcC>tcT	p.S279S		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	279						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		TTGTGGAATCCGTGGAGTCCT	0.647000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	37					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2910159	2910159	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:2910159A>T	ENST00000520002.1	-	51	8043	c.7488T>A	c.(7486-7488)tgT>tgA	p.C2496*	CSMD1_ENST00000542608.1_Nonsense_Mutation_p.C2495*|CSMD1_ENST00000537824.1_Nonsense_Mutation_p.C2495*|CSMD1_ENST00000602723.1_Nonsense_Mutation_p.C2496*|CSMD1_ENST00000400186.3_Nonsense_Mutation_p.C2496*|CSMD1_ENST00000602557.1_Nonsense_Mutation_p.C2496*			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2496	Sushi 15.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTGGGATTCCACAGGACACAG	0.368000													7	6					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30900224	30900224	+	Silent	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:30900224A>G	ENST00000597505.1	-	36	5258	c.5259T>C	c.(5257-5259)taT>taC	p.Y1753Y				P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GGATTCTGGCATAATTTGCTC	0.398000													21	8					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39537692	39537692	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:39537692G>T	ENST00000265707.5	+	16	1813	c.1768G>T	c.(1768-1770)Gat>Tat	p.D590Y	ADAM18_ENST00000541111.1_Missense_Mutation_p.D4Y|ADAM18_ENST00000379866.1_Missense_Mutation_p.D566Y	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	590	Cys-rich.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CATGAGATCAGATGGAACAGA	0.358000													5	17					5.9392e-07	7.05947e-07	1	1	0
MCM7	4176	broad.mit.edu	37	7	99696770	99696770	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:99696770C>T	ENST00000303887.5	-	5	1103	c.458G>A	c.(457-459)cGg>cAg	p.R153Q	MCM7_ENST00000354230.3_5'UTR|MCM7_ENST00000343023.6_Missense_Mutation_p.R153Q	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	153					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	AGAGTCAGCCCGCACTTCCCG	0.512000													16	72					0	0	1	0	0
ACTBL2	345651	broad.mit.edu	37	5	56778406	56778406	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:56778406G>A	ENST00000423391.1	-	1	230	c.129C>T	c.(127-129)ggC>ggT	p.G43G	CTD-2023N9.1_ENST00000506106.1_RNA	NM_001017992.3	NP_001017992.1	Q562R1	ACTBL_HUMAN	actin, beta-like 2	43						cytoplasm|cytoskeleton	ATP binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(3)|pancreas(1)|prostate(2)	28		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		CTACCATAACGCCCTGGTGTC	0.587000													5	17					0	0	1	0	0
ABCA3	21	broad.mit.edu	37	16	2349403	2349403	+	Splice_Site	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:2349403C>A	ENST00000301732.5	-	14	2442		c.e14+1		ABCA3_ENST00000382381.3_Splice_Site	NM_001089.2	NP_001080.2	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 3						response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(7)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(7)|prostate(5)|skin(6)|upper_aerodigestive_tract(1)	70		Ovarian(90;0.17)				CTGGCCCTCACCTGTGAGCAT	0.657000													33	34					1.74807e-11	2.37666e-11	1	1	0
MTA1	9112	broad.mit.edu	37	14	105931137	105931137	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:105931137C>T	ENST00000331320.7	+	15	1685	c.1471C>T	c.(1471-1473)Cgc>Tgc	p.R491C	MTA1_ENST00000406191.1_Missense_Mutation_p.R491C|MTA1_ENST00000435036.2_Missense_Mutation_p.R27C|MTA1_ENST00000405646.1_Missense_Mutation_p.R474C	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1	491					signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		TGAGATCCTGCGCCCGTGGCA	0.657000													9	20					0	0	1	0	0
DHX57	90957	broad.mit.edu	37	2	39088949	39088949	+	Silent	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:39088949C>T	ENST00000295373.6	-	5	729	c.603G>A	c.(601-603)gcG>gcA	p.A201A	AC018693.6_ENST00000442829.1_RNA|DHX57_ENST00000479345.2_5'UTR	NM_198963.1	NP_945314.1	Q6P158	DHX57_HUMAN	DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57	201	UBA.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(20)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	62		all_hematologic(82;0.248)				TCCTCAGGACCGCTTGACAGC	0.423000													12	28					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69380961	69380961	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:69380961G>C	ENST00000337103.4	+	3	1901	c.309G>C	c.(307-309)tgG>tgC	p.W103C	C8orf34_ENST00000348340.2_Missense_Mutation_p.W128C|C8orf34_ENST00000349492.3_Intron|C8orf34_ENST00000539993.1_Missense_Mutation_p.W128C|C8orf34_ENST00000518698.1_Missense_Mutation_p.W214C			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	128					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			AGTGGAACTGGAGGACTAAAC	0.398000													12	30					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190129925	190129925	+	Missense_Mutation	SNP	G	G	C	rs147790033		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:190129925G>C	ENST00000367462.3	-	7	1288	c.1057C>G	c.(1057-1059)Cgc>Ggc	p.R353G	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.R251G	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		353						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					TCATAACGGCGCTGAAAATTA	0.353000													32	66					0	0	1	0	0
SIRPG	55423	broad.mit.edu	37	20	1616067	1616067	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:1616067G>T	ENST00000381580.1	-	4	1007	c.828C>A	c.(826-828)aaC>aaA	p.N276K	SIRPG_ENST00000344103.4_Intron|RP11-77C3.3_ENST00000456177.1_RNA|SIRPG_ENST00000303415.3_Missense_Mutation_p.N309K|SIRPG_ENST00000216927.4_Intron|SIRPG_ENST00000381583.2_Intron			Q9P1W8	SIRPG_HUMAN	signal-regulatory protein gamma	309	Ig-like C1-type 2.				blood coagulation|cell adhesion|cell junction assembly|cell-cell signaling|intracellular signal transduction|leukocyte migration|negative regulation of cell proliferation|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to membrane|intracellular|plasma membrane	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|stomach(1)	27						AGCTTGTCCAGTTGTAGGTAC	0.547000													22	70					1.16021e-09	1.49546e-09	1	1	0
COL28A1	340267	broad.mit.edu	37	7	7415129	7415129	+	Splice_Site	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:7415129C>A	ENST00000399429.3	-	31	2463		c.e31-1			NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1						cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TTTCTTCTTTCTAGGGGATAA	0.313000													12	15					0.00136819	0.00144078	1	1	0
OR1C1	26188	broad.mit.edu	37	1	247921346	247921346	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:247921346A>T	ENST00000408896.2	-	1	636	c.363T>A	c.(361-363)gaT>gaA	p.D121E		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	121					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			CCACATATCTATCATACGCCA	0.493000													13	55					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77912559	77912559	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:77912559A>T	ENST00000321110.1	-	2	1654	c.1359T>A	c.(1357-1359)caT>caA	p.H453Q		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	453							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						CTCTGGCAAAATGACCAGGAT	0.547000													40	14					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92953017	92953017	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:92953017A>G	ENST00000544910.1	+	22	2080	c.1860A>G	c.(1858-1860)atA>atG	p.I620M	CCDC132_ENST00000541136.1_Missense_Mutation_p.I461M|CCDC132_ENST00000305866.5_Missense_Mutation_p.I650M|CCDC132_ENST00000535481.1_Missense_Mutation_p.I370M	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	650										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			TGTATGCAATATATACCTTTT	0.274000													7	30					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113933929	113933929	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:113933929G>T	ENST00000297405.5	-	10	1804	c.1560C>A	c.(1558-1560)ggC>ggA	p.G520G	CSMD3_ENST00000343508.3_Silent_p.G480G|CSMD3_ENST00000352409.3_Silent_p.G520G|CSMD3_ENST00000455883.2_Silent_p.G416G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	520	Sushi 2.					integral to membrane|plasma membrane		p.G520G(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGCTCTTTGCGCCCTGTAGGA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			19	39					8.10497e-08	9.80998e-08	1	1	0
LOC146880	146880	broad.mit.edu	37	17	62748014	62748014	+	RNA	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:62748014C>A	ENST00000400873.3	-	0	2295					NR_026899.1																						ATTTTGTCTACGCCTCCACAT	0.343000													3	47					0.115264	0.116734	1	1	0
MYOM2	9172	broad.mit.edu	37	8	2054110	2054110	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:2054110C>A	ENST00000262113.4	+	22	2954	c.2813C>A	c.(2812-2814)gCg>gAg	p.A938E	MYOM2_ENST00000523438.1_Missense_Mutation_p.A363E	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	938	Ig-like C2-type 3.				muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		ATGACAGACGCGTCTCAGTTC	0.483000													17	49					0.006122	0.00634579	1	1	0
FER1L5	90342	broad.mit.edu	37	2	97368737	97368737	+	RNA	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:97368737C>T	ENST00000457909.1	+	0	4923							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						AGCCTGGATGCCACGTCCATG	0.587000													3	23					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112303	248112303	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:248112303C>G	ENST00000357191.3	+	1	144	c.144C>G	c.(142-144)atC>atG	p.I48M	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	48					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TTCTTCTCATCTTCTTGGACA	0.418000													8	376					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38797411	38797411	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:38797411G>T	ENST00000449082.2	-	10	1328	c.1329C>A	c.(1327-1329)caC>caA	p.H443Q		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	443					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CATTGTGGGAGTGGAGAGAGG	0.468000													50	27					7.47603e-22	1.22644e-21	1	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106579342	106579342	+	Silent	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:106579342C>T	ENST00000526355.1	-	7	2355	c.1887G>A	c.(1885-1887)gtG>gtA	p.V629V	GUCY1A2_ENST00000282249.2_Silent_p.V660V|GUCY1A2_ENST00000347596.2_Silent_p.V650V	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	629	Guanylate cyclase.				intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		GTGGCATTCGCACCCCAACAA	0.463000													9	52					0	0	1	0	0
BTN1A1	696	broad.mit.edu	37	6	26509247	26509247	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:26509247G>T	ENST00000244513.6	+	7	1492	c.1426G>T	c.(1426-1428)Gct>Tct	p.A476S		NM_001732.2	NP_001723.2	Q13410	BT1A1_HUMAN	butyrophilin, subfamily 1, member A1	476	B30.2/SPRY.					extracellular region|integral to plasma membrane	receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(1)	26						CTGCCCAATTGCTGATGGGCC	0.537000													33	16					1.06647e-15	1.62218e-15	1	1	0
KRTAP21-1	337977	broad.mit.edu	37	21	32127623	32127623	+	Missense_Mutation	SNP	C	C	A	rs147233060	byFrequency	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr21:32127623C>A	ENST00000335093.3	-	1	123	c.74G>T	c.(73-75)gGc>gTc	p.G25V		NM_181619.1	NP_853650.1	Q3LI58	KR211_HUMAN	keratin associated protein 21-1	25						intermediate filament		p.G25A(1)		breast(1)|endometrium(1)|lung(4)|urinary_tract(1)	7						acagccacagccagagccaga	0.537000													26	75					4.7796e-09	6.06231e-09	1	1	0
ISL2	64843	broad.mit.edu	37	15	76632832	76632832	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:76632832C>G	ENST00000290759.4	+	4	887	c.727C>G	c.(727-729)Cgc>Ggc	p.R243G	RP11-685G9.2_ENST00000559539.1_RNA	NM_145805.1	NP_665804.1	Q96A47	ISL2_HUMAN	ISL LIM homeobox 2	243						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6						CCAGAACAAGCGCTGCAAGGA	0.637000													4	43					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7579329	7579329	+	Missense_Mutation	SNP	T	T	C	rs121912658		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:7579329T>C	ENST00000420246.2	-	4	490	c.358A>G	c.(358-360)Aag>Gag	p.K120E	TP53_ENST00000413465.2_Missense_Mutation_p.K120E|TP53_ENST00000269305.4_Missense_Mutation_p.K120E|TP53_ENST00000455263.2_Missense_Mutation_p.K120E|TP53_ENST00000445888.2_Missense_Mutation_p.K120E|TP53_ENST00000359597.4_Missense_Mutation_p.K120E	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	120	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.	Interaction with DNA.	K -> E (in sporadic cancers; somatic mutation).|K -> M (in sporadic cancers; somatic mutation).|K -> Q (in a sporadic cancer; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.K120E(3)|p.G59fs*23(3)|p.K120*(2)|p.V73fs*9(1)|p.G105_T125del21(1)|p.G112_V122delGFLHSGTAKSV(1)|p.T118fs*27(1)|p.H115fs*27(1)|p.Y107fs*44(1)|p.K120Q(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.K120fs*3(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTCACAGACTTGGCTGTCCCA	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			25	18					0	0	1	0	0
RTCB	51493	broad.mit.edu	37	22	32789884	32789884	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr22:32789884C>T	ENST00000216038.5	-	10	1383	c.1285G>A	c.(1285-1287)Gga>Aga	p.G429R	RTCB_ENST00000451746.2_Intron	NM_014306.4	NP_055121.1			RNA 2',3'-cyclic phosphate and 5'-OH ligase																		CTTACCGCTCCATGACAGGTT	0.438000													11	33					0	0	1	0	0
DOCK10	55619	broad.mit.edu	37	2	225717692	225717692	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:225717692G>A	ENST00000409592.3	-	17	2131	c.2018C>T	c.(2017-2019)cCc>cTc	p.P673L	DOCK10_ENST00000258390.7_Missense_Mutation_p.P679L			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	679	DHR-1.						GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		GAGGTGTTTGGGGTAAATATA	0.348000													20	26					0	0	1	0	0
PPP2R2B	5521	broad.mit.edu	37	5	146017924	146017924	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:146017924G>T	ENST00000394413.3	-	6	1250	c.680C>A	c.(679-681)gCa>gAa	p.A227E	PPP2R2B_ENST00000394414.1_Missense_Mutation_p.A293E|PPP2R2B_ENST00000394411.4_Missense_Mutation_p.A227E|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.A216E|PPP2R2B_ENST00000356826.3_Missense_Mutation_p.A227E|PPP2R2B_ENST00000453001.1_Missense_Mutation_p.A227E|PPP2R2B_ENST00000394409.3_Missense_Mutation_p.A285E|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.A233E|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.A230E|PPP2R2B_ENST00000508545.2_Missense_Mutation_p.A216E			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	227					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAACTCGGCTGCTGTGATCAC	0.557000													13	14					6.31663e-08	7.69233e-08	1	1	0
ARPP21	10777	broad.mit.edu	37	3	35763238	35763238	+	Silent	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:35763238C>T	ENST00000187397.4	+	14	1593	c.1137C>T	c.(1135-1137)acC>acT	p.T379T	ARPP21_ENST00000337271.5_Silent_p.T325T|ARPP21_ENST00000417925.1_Silent_p.T345T|ARPP21_ENST00000458225.1_Silent_p.T345T|ARPP21_ENST00000444190.1_Silent_p.T325T	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	379	Ser-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CCGCCATGACCAAGACGGCGA	0.547000													6	13					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178416315	178416315	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:178416315T>G	ENST00000231188.5	-	5	1282	c.1104A>C	c.(1102-1104)aaA>aaC	p.K368N	RP11-281O15.4_ENST00000519491.1_RNA|GRM6_ENST00000517717.1_Missense_Mutation_p.K368N	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	368					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		AGCTGGTCAGTTTGCAGTTAA	0.552000													40	47					0	0	1	0	0
REG3G	130120	broad.mit.edu	37	2	79253889	79253889	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:79253889G>A	ENST00000272324.5	+	3	311	c.127G>A	c.(127-129)Ggc>Agc	p.G43S	REG3G_ENST00000393897.2_Missense_Mutation_p.G43S|REG3G_ENST00000409471.1_Missense_Mutation_p.G43S	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	43					acute-phase response	extracellular region	sugar binding	p.G43S(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CTGTCCCAAAGGCTCCAAGGC	0.522000													23	27					0	0	1	0	0
BTG4	54766	broad.mit.edu	37	11	111365888	111365888	+	Splice_Site	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:111365888C>A	ENST00000356018.2	-	5	861	c.662_splice	c.e5+1	p.R221_splice		NM_017589.3	NP_060059.1	Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	221					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation					large_intestine(2)|upper_aerodigestive_tract(1)	3		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		CCAGTGGTACCTGTCCAGCCG	0.527000													36	30					1.57945e-13	2.30531e-13	1	1	0
TRHR	7201	broad.mit.edu	37	8	110131524	110131524	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:110131524C>A	ENST00000518632.1	+	3	1388	c.1037C>A	c.(1036-1038)gCt>gAt	p.A346D	TRHR_ENST00000311762.2_Missense_Mutation_p.A346D			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	346						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GAGAAACCTGCTAACTACAGT	0.478000													12	43					0.00136819	0.00144078	1	1	0
ZNF767	79970	broad.mit.edu	37	7	149318144	149318144	+	RNA	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:149318144G>C	ENST00000463567.1	-	0	486					NR_027788.1				zinc finger family member 767											central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(1)	5	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00434)			TACCCAAAGAGACCAGCATCT	0.498000													5	89					0	0	1	0	0
ABCB11	8647	broad.mit.edu	37	2	169836414	169836414	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:169836414G>A	ENST00000263817.6	-	11	1283	c.1159C>T	c.(1159-1161)Cgt>Tgt	p.R387C		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	387					bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GCTGCTGCACGTCCAGTTGCA	0.453000													8	22					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139726083	139726083	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:139726083C>A	ENST00000263549.3	-	11	2567	c.1694G>T	c.(1693-1695)gGc>gTc	p.G565V		NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12	565	PARP catalytic.					nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					GGCGCTGGTGCCGTGGAACAG	0.567000													41	95					5.85753e-14	8.64476e-14	1	1	0
ANK2	287	broad.mit.edu	37	4	114274486	114274486	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:114274486G>A	ENST00000357077.4	+	38	4765	c.4712G>A	c.(4711-4713)tGc>tAc	p.C1571Y	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.C1538Y|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1538					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGTGGAACCTGCACAAGAGAT	0.453000													8	20					0	0	1	0	0
HOXA1	3198	broad.mit.edu	37	7	27134105	27134105	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:27134105G>T	ENST00000343060.4	-	2	1023	c.962C>A	c.(961-963)cCt>cAt	p.P321H	HOXA1_ENST00000355633.5_3'UTR	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	321						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CCCCGGGGAAGGAACGCAGGG	0.617000													15	31					8.00594e-06	9.15953e-06	1	1	0
ANKRD44	91526	broad.mit.edu	37	2	197870518	197870518	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:197870518G>A	ENST00000328737.2	-	21	2248	c.2172C>T	c.(2170-2172)gcC>gcT	p.A724A	ANKRD44_ENST00000282272.8_Silent_p.A741A|ANKRD44_ENST00000450567.1_Silent_p.A724A|ANKRD44_ENST00000337207.5_Silent_p.A724A			Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	749							protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(20)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TCAGCCACGTGGCGTGGCCAC	0.522000													56	125					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36775745	36775745	+	Silent	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:36775745A>G	ENST00000280527.2	+	17	3379	c.3012A>G	c.(3010-3012)agA>agG	p.R1004R	AC007401.2_ENST00000406220.1_Intron	NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	1004					nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				GTTCCCAGAGAATGCTAAGAA	0.418000													3	55					0	0	1	0	0
NT5C1B	93034	broad.mit.edu	37	2	18757471	18757471	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:18757471A>T	ENST00000304081.4	-	8	1408	c.1308T>A	c.(1306-1308)tgT>tgA	p.C436*	NT5C1B_ENST00000600945.1_Nonsense_Mutation_p.C496*|NT5C1B-RDH14_ENST00000532967.1_Nonsense_Mutation_p.C496*|NT5C1B_ENST00000359846.2_Nonsense_Mutation_p.C496*	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GCTTACTTTCACATAATGTAT	0.358000													14	19					0	0	1	0	0
UBALD1	124402	broad.mit.edu	37	16	4664794	4664794	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:4664794G>C	ENST00000590965.1	-	1	81	c.5C>G	c.(4-6)tCc>tGc	p.S2C	UBALD1_ENST00000587649.1_Missense_Mutation_p.S2C|UBALD1_ENST00000283474.7_Missense_Mutation_p.S2C|UBALD1_ENST00000587615.1_Missense_Mutation_p.S2C|UBALD1_ENST00000591897.1_Intron|UBALD1_ENST00000591401.1_Missense_Mutation_p.S2C					UBA-like domain containing 1																		CATGTTCACGGACATGGCGCC	0.682000													4	29					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73787156	73787156	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:73787156T>G	ENST00000342056.2	+	4	1126	c.728T>G	c.(727-729)gTg>gGg	p.V243G	KCNQ5_ENST00000370398.1_Missense_Mutation_p.V243G|KCNQ5_ENST00000355635.3_Missense_Mutation_p.V243G|KCNQ5_ENST00000355194.4_Missense_Mutation_p.V243G|KCNQ5_ENST00000414165.2_Missense_Mutation_p.V243G|KCNQ5_ENST00000403813.2_Missense_Mutation_p.V243G|KCNQ5_ENST00000402622.2_Missense_Mutation_p.V243G|KCNQ5_ENST00000370392.1_Missense_Mutation_p.V243G	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	243					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CTCCGCATGGTGCGCATGGAC	0.438000													18	25					0	0	1	0	0
KDM6B	23135	broad.mit.edu	37	17	7750744	7750744	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:7750744C>T	ENST00000254846.5	+	10	1620	c.1231C>T	c.(1231-1233)Cgg>Tgg	p.R411W	KDM6B_ENST00000448097.2_Missense_Mutation_p.R411W	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	411	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						caCTGGTCTCCGGGGCGTGGA	0.662000													23	14					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65346837	65346837	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:65346837C>A	ENST00000483466.1	-	23	3999	c.3758G>T	c.(3757-3759)gGc>gTc	p.G1253V	MAGI1_ENST00000330909.8_Intron|MAGI1_ENST00000497477.2_Missense_Mutation_p.G1157V|MAGI1_ENST00000402939.2_Intron	NM_004742.2	NP_004733.2	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	0					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		TGGAGTCATGCCAGGGAAGGA	0.478000													18	18					7.41877e-09	9.32042e-09	1	1	0
CCDC108	255101	broad.mit.edu	37	2	219903188	219903188	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:219903188C>A	ENST00000341552.5	-	4	349	c.266G>T	c.(265-267)gGt>gTt	p.G89V	CCDC108_ENST00000324264.6_Missense_Mutation_p.G24V|CCDC108_ENST00000409865.3_Missense_Mutation_p.G78V|CCDC108_ENST00000410037.1_Missense_Mutation_p.G24V|CCDC108_ENST00000441968.1_Missense_Mutation_p.G89V|CCDC108_ENST00000453220.1_Missense_Mutation_p.G89V|CCDC108_ENST00000295729.2_Missense_Mutation_p.G24V	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	89						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCAGGATCCACCAGAGTTCAC	0.592000													15	48					1.52009e-12	2.13242e-12	1	1	0
GPR83	10888	broad.mit.edu	37	11	94113869	94113869	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:94113869C>A	ENST00000243673.2	-	4	889	c.718G>T	c.(718-720)Gac>Tac	p.D240Y	GPR83_ENST00000539203.2_Missense_Mutation_p.D198Y	NM_016540.3	NP_057624.3	Q9NYM4	GPR83_HUMAN	G protein-coupled receptor 83	240						integral to membrane|plasma membrane	neuropeptide Y receptor activity			NS(1)|breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	19		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				GTGGCCAAGTCCAGGTACTTC	0.577000													29	31					5.90632e-09	7.44384e-09	1	1	0
EIF4G3	8672	broad.mit.edu	37	1	21177969	21177969	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:21177969C>T	ENST00000602326.1	-	26	3987	c.3404G>A	c.(3403-3405)cGt>cAt	p.R1135H	EIF4G3_ENST00000537738.1_Missense_Mutation_p.R619H|EIF4G3_ENST00000264211.8_Missense_Mutation_p.R1129H|EIF4G3_ENST00000374935.3_Missense_Mutation_p.R849H|EIF4G3_ENST00000400422.1_Missense_Mutation_p.R1129H|EIF4G3_ENST00000536266.1_Missense_Mutation_p.R733H|EIF4G3_ENST00000374937.3_Missense_Mutation_p.R1135H	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1129					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CATACTTCCACGACTTAAAAG	0.423000													10	20					0	0	1	0	0
CPNE6	9362	broad.mit.edu	37	14	24546879	24546879	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:24546879C>A	ENST00000397016.2	+	17	1925	c.1614C>A	c.(1612-1614)ggC>ggA	p.G538G	CPNE6_ENST00000537691.1_Silent_p.G593G|CPNE6_ENST00000216775.2_Silent_p.G538G			O95741	CPNE6_HUMAN	copine VI (neuronal)	538					lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		CCAGCCAGGGCATCAGCCCTG	0.672000													19	62					2.94398e-08	3.641e-08	1	1	0
HERC2	8924	broad.mit.edu	37	15	28413618	28413618	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:28413618C>T	ENST00000261609.7	-	67	10456	c.10348G>A	c.(10348-10350)Gaa>Aaa	p.E3450K		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3450					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		AGCATGCATTCTTCTCCATTC	0.532000													24	96					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32171982	32171982	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:32171982G>A	ENST00000375023.3	-	19	3188	c.3050C>T	c.(3049-3051)cCc>cTc	p.P1017L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1017	EGF-like 26.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						AGTGCCTGTGGGGTGGCAGGG	0.617000													6	32					0	0	1	0	0
FTH1P10	2502	broad.mit.edu	37	5	17353980	17353980	+	RNA	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:17353980G>T	ENST00000401830.3	-	0	753					NR_002201.1																						TTAGCCTGAGGCTTAGCTTTC	0.493000													3	34					0.115264	0.116734	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141607808	141607808	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:141607808G>T	ENST00000389484.3	-	29	5773	c.4802C>A	c.(4801-4803)aCa>aAa	p.T1601K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1601					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATCAGGGACTGTAAATGCCGT	0.343000										TSP Lung(27;0.18)			4	39					3.59834e-05	3.99033e-05	1	1	0
PCLO	27445	broad.mit.edu	37	7	82474677	82474677	+	Silent	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:82474677T>A	ENST00000423517.2	-	13	14293	c.13956A>T	c.(13954-13956)tcA>tcT	p.S4652S	PCLO_ENST00000426442.2_5'UTR|PCLO_ENST00000333891.8_Silent_p.S4652S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4540	C2 1.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ATGTAGGACCTGAATGAACAT	0.517000													5	33					0	0	1	0	0
HS3ST1	9957	broad.mit.edu	37	4	11401183	11401183	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:11401183C>A	ENST00000002596.5	-	2	1621	c.447G>T	c.(445-447)ccG>ccT	p.P149P		NM_005114.2	NP_005105.1	O14792	HS3S1_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 1	149						Golgi lumen|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|skin(3)	15						CGCGCTCCGACGGGTCTCGCA	0.592000													7	24					0.000157383	0.000171652	1	1	0
NSDHL	50814	broad.mit.edu	37	X	152018810	152018810	+	Splice_Site	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:152018810C>A	ENST00000370274.3	+	3	304	c.108_splice	c.e3-1	p.A37_splice	NSDHL_ENST00000440023.1_Splice_Site_p.A37_splice	NM_015922.2	NP_057006.1	Q15738	NSDHL_HUMAN	NAD(P) dependent steroid dehydrogenase-like	37					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity|sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity			NS(1)|breast(1)|cervix(1)|endometrium(4)|large_intestine(3)|lung(5)	15	Acute lymphoblastic leukemia(192;6.56e-05)				NADH(DB00157)	TTTCCACAGGCCAAGAGATGC	0.512000													23	100					4.72057e-08	5.76636e-08	1	1	0
ZNF772	400720	broad.mit.edu	37	19	57985525	57985525	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:57985525C>A	ENST00000343280.4	-	5	847	c.587G>T	c.(586-588)gGa>gTa	p.G196V	ZNF772_ENST00000427512.2_Missense_Mutation_p.G84V|ZNF772_ENST00000601768.1_Intron|ZNF772_ENST00000356584.3_Missense_Mutation_p.G155V|ZNF772_ENST00000425074.3_3'UTR|AC004076.9_ENST00000415705.3_Intron|ZNF772_ENST00000600175.1_Intron|AC004076.9_ENST00000596831.1_Intron	NM_001024596.2	NP_001019767.1	Q68DY9	ZN772_HUMAN	zinc finger protein 772	196					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(4)|lung(3)	9		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)|Lung(386;0.174)		GGGTTTCTCTCCACTGTGCTG	0.488000													10	55					2.27111e-07	2.72396e-07	1	1	0
ATP13A3	79572	broad.mit.edu	37	3	194154508	194154508	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:194154508C>A	ENST00000439040.1	-	21	3029	c.2238G>T	c.(2236-2238)atG>atT	p.M746I	ATP13A3_ENST00000256031.4_Missense_Mutation_p.M746I			Q9H7F0	AT133_HUMAN	ATPase type 13A3	746					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	24	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		AACCTGTGACCATGACGGTGC	0.338000													18	26					3.6726e-16	5.62943e-16	1	1	0
DAW1	164781	broad.mit.edu	37	2	228786155	228786155	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:228786155G>T	ENST00000309931.2	+	12	1174	c.1091G>T	c.(1090-1092)aGc>aTc	p.S364I	DAW1_ENST00000545118.1_Missense_Mutation_p.S349I|DAW1_ENST00000373666.2_3'UTR	NM_178821.1	NP_849143.1			dynein assembly factor with WDR repeat domains 1																		CTAACTGGCAGCTCTGACAAA	0.428000													23	47					7.01153e-11	9.40398e-11	1	1	0
PIGN	23556	broad.mit.edu	37	18	59713182	59713182	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr18:59713182C>A	ENST00000357637.5	-	31	3118	c.2703G>T	c.(2701-2703)atG>atT	p.M901I	PIGN_ENST00000400334.3_Missense_Mutation_p.M901I	NM_176787.4	NP_789744.1	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class N	901					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(73;0.187)				AAAAGATGGTCATGGACATGA	0.453000													7	6					2.17888e-05	2.42982e-05	1	1	0
SLITRK3	22865	broad.mit.edu	37	3	164907524	164907524	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:164907524G>T	ENST00000475390.1	-	2	1538	c.1095C>A	c.(1093-1095)acC>acA	p.T365T	SLITRK3_ENST00000241274.3_Silent_p.T365T			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	365	LRRNT.					integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TTGGTGGTCTGGTCTGATAAG	0.502000										HNSCC(40;0.11)			123	109					1.75003e-54	3.17243e-54	1	1	0
OR2D2	120776	broad.mit.edu	37	11	6913141	6913141	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:6913141C>T	ENST00000299459.2	-	1	689	c.591G>A	c.(589-591)atG>atA	p.M197I		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GAAAAATGGCCATCTCTGATG	0.453000													7	28					0	0	1	0	0
ABCB1	5243	broad.mit.edu	37	7	87190657	87190657	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:87190657G>T	ENST00000265724.3	-	9	1166	c.749C>A	c.(748-750)gCt>gAt	p.A250D	ABCB1_ENST00000543898.1_Missense_Mutation_p.A186D	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	250	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	TACTGCTCCAGCTTTTGCATA	0.318000													3	28					2.56e-06	2.9717e-06	1	1	0
HPD	3242	broad.mit.edu	37	12	122295276	122295276	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:122295276G>T	ENST00000543163.1	-	5	484	c.39C>A	c.(37-39)acC>acA	p.T13T	HPD_ENST00000289004.4_Silent_p.T52T	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	52					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	CCCGGGAACCGGTCTCCAGGC	0.582000													50	65					2.41709e-19	3.86929e-19	1	1	0
XPOT	11260	broad.mit.edu	37	12	64812830	64812830	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:64812830A>G	ENST00000332707.5	+	6	974	c.445A>G	c.(445-447)Att>Gtt	p.I149V		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	149	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		CCTCATGGCTATTGATTCAGA	0.388000													19	125					0	0	1	0	0
NKD1	85407	broad.mit.edu	37	16	50659433	50659433	+	Missense_Mutation	SNP	G	G	T	rs141900711	byFrequency	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:50659433G>T	ENST00000268459.3	+	6	628	c.404G>T	c.(403-405)cGg>cTg	p.R135L		NM_033119.4	NP_149110.1	Q969G9	NKD1_HUMAN	naked cuticle homolog 1 (Drosophila)	135	EF-hand.|Interaction with DVL1, DVL2 and DVL3 (By similarity).				Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(9)|prostate(1)|urinary_tract(2)	23		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		GAGGACAGCCGGCAGGAGTGG	0.602000													17	50					4.35082e-09	5.55394e-09	1	1	0
SIPA1L3	23094	broad.mit.edu	37	19	38632048	38632048	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:38632048G>T	ENST00000222345.6	+	11	3877	c.3368G>T	c.(3367-3369)cGg>cTg	p.R1123L		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	1123					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GTCCCCTTCCGGGAGTCCCAG	0.647000													39	91					3.43241e-23	5.7255e-23	1	1	0
ARSF	416	broad.mit.edu	37	X	3002584	3002584	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:3002584G>T	ENST00000381127.1	+	6	928	c.707G>T	c.(706-708)aGc>aTc	p.S236I	ARSF_ENST00000537104.1_Missense_Mutation_p.S236I|ARSF_ENST00000359361.2_Missense_Mutation_p.S236I	NM_001201538.1|NM_001201539.1	NP_001188467.1|NP_001188468.1	P54793	ARSF_HUMAN	arylsulfatase F	236						extracellular region	arylsulfatase activity|metal ion binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	38		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				TGGTTCTCCAGCCACACGTCC	0.542000													19	66					1.45105e-14	2.18207e-14	1	1	0
SNX24	28966	broad.mit.edu	37	5	122281796	122281796	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:122281796G>A	ENST00000261369.4	+	3	376	c.191G>A	c.(190-192)aGg>aAg	p.R64K	SNX24_ENST00000513881.1_Missense_Mutation_p.R64K|SNX24_ENST00000395451.4_Missense_Mutation_p.R97K|SNX24_ENST00000511211.1_3'UTR|SNX24_ENST00000506996.1_Missense_Mutation_p.R64K	NM_014035.2	NP_054754.1	Q9Y343	SNX24_HUMAN	sorting nexin 24	64	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			lung(5)	5		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		AAACATGTTAGGAACTGGGTC	0.323000													8	21					0	0	1	0	0
CECR7	100130418	broad.mit.edu	37	22	17528314	17528314	+	RNA	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr22:17528314C>A	ENST00000441006.1	+	0	1004					NR_015352.1																						GTGACAGCCCCATGTAAGTAC	0.552000													7	5					5.4927e-09	6.9446e-09	1	1	0
F7	2155	broad.mit.edu	37	13	113773108	113773108	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr13:113773108G>T	ENST00000375581.3	+	9	1222	c.1187G>T	c.(1186-1188)aGc>aTc	p.S396I	F7_ENST00000541084.1_Missense_Mutation_p.S327I|F7_ENST00000346342.3_Missense_Mutation_p.S374I	NM_000131.4	NP_000122.1	P08709	FA7_HUMAN	coagulation factor VII (serum prothrombin conversion accelerator)	396	Peptidase S1.				anti-apoptosis|blood coagulation, extrinsic pathway|peptidyl-glutamic acid carboxylation|positive regulation of leukocyte chemotaxis|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of positive chemotaxis|positive regulation of protein kinase B signaling cascade|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|Golgi lumen|plasma membrane	calcium ion binding|glycoprotein binding|serine-type endopeptidase activity			large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	16	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0364)|all_epithelial(44;0.0393)|Lung NSC(25;0.128)|Breast(118;0.188)	all cancers(43;0.0737)|Epithelial(84;0.213)|BRCA - Breast invasive adenocarcinoma(86;0.218)		Coagulation Factor IX(DB00100)|Coagulation factor VIIa(DB00036)|Menadione(DB00170)	TCGGATGGCAGCAAGGACTCC	0.642000													6	18					5.18039e-06	5.94398e-06	1	1	0
RELN	5649	broad.mit.edu	37	7	103180648	103180648	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:103180648T>A	ENST00000428762.1	-	44	7085	c.6926A>T	c.(6925-6927)gAt>gTt	p.D2309V	RELN_ENST00000343529.5_Missense_Mutation_p.D2309V|RELN_ENST00000424685.2_Missense_Mutation_p.D2309V	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2309					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ACTGACCTGATCGATAACCCA	0.488000													18	50					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54783406	54783406	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:54783406C>A	ENST00000391748.1	-	5	579	c.452G>T	c.(451-453)gGc>gTc	p.G151V	LILRB2_ENST00000314446.5_Missense_Mutation_p.G151V|LILRB2_ENST00000391746.1_Missense_Mutation_p.G151V|LILRB2_ENST00000391749.4_Missense_Mutation_p.G151V|LILRB2_ENST00000434421.1_Missense_Mutation_p.G35V	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	151	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AATGAAGCCGCCAAATGCCAC	0.607000													35	46					7.53189e-24	1.26702e-23	1	1	0
MTBP	27085	broad.mit.edu	37	8	121457828	121457828	+	Splice_Site	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:121457828G>C	ENST00000305949.1	+	1	163	c.118_splice	c.e1+1	p.D40_splice		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	40					cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			GAATCAGCCGGGTAAGCGCTG	0.547000													7	42					0	0	1	0	0
OPN3	23596	broad.mit.edu	37	1	241757995	241757995	+	Splice_Site	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:241757995T>A	ENST00000366554.2	-	4	1052		c.e4-2		OPN3_ENST00000469376.1_Splice_Site|KMO_ENST00000366557.4_3'UTR|KMO_ENST00000366559.4_3'UTR|OPN3_ENST00000331838.5_Splice_Site	NM_014322.2	NP_055137.2	Q9H1Y3	OPN3_HUMAN	opsin 3						phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity			endometrium(1)|large_intestine(5)|lung(5)	11	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			TCTTCGAAACTGGGCAGAGAA	0.428000													21	61					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51169805	51169805	+	Silent	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:51169805T>A	ENST00000293441.1	-	22	5430	c.5412A>T	c.(5410-5412)tcA>tcT	p.S1804S	SHANK1_ENST00000391814.1_Silent_p.S1812S|SHANK1_ENST00000391813.1_Silent_p.S1191S|SYT3_ENST00000544769.1_Intron|SHANK1_ENST00000359082.3_Silent_p.S1795S	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1804					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TGGGGGGTCCTGAACAAGCAC	0.716000													3	5					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123587252	123587252	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:123587252T>A	ENST00000422452.2	-	23	4102	c.4039A>T	c.(4039-4041)Atc>Ttc	p.I1347F	TENM1_ENST00000371130.3_Missense_Mutation_p.I1340F	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		TTTGAGCCGATTACAGTTGTG	0.418000													17	79					0	0	1	0	0
JADE2	23338	broad.mit.edu	37	5	133895665	133895665	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:133895665G>T	ENST00000395003.1	+	5	636	c.457G>T	c.(457-459)Gag>Tag	p.E153*	PHF15_ENST00000282605.4_Nonsense_Mutation_p.E153*|PHF15_ENST00000361895.2_Nonsense_Mutation_p.E153*|PHF15_ENST00000402835.1_Nonsense_Mutation_p.E153*	NM_015288.4	NP_056103.4	Q9NQC1	JADE2_HUMAN		153					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATCAACTCGGAGCTTAAGGA	0.592000													12	12					3.27435e-08	4.03701e-08	1	1	0
F8	2157	broad.mit.edu	37	X	154091369	154091369	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:154091369C>T	ENST00000360256.4	-	23	6763	c.6563G>A	c.(6562-6564)tGt>tAt	p.C2188Y	F8_ENST00000330287.6_Missense_Mutation_p.C53Y	NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2188	F5/8 type C 1.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	ATTTAAATCACAGCCCATCAA	0.443000													21	95					0	0	1	0	0
PPFIA4	8497	broad.mit.edu	37	1	203029447	203029447	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:203029447A>T	ENST00000367240.2	+	21	3150	c.2623A>T	c.(2623-2625)Atc>Ttc	p.I875F	PPFIA4_ENST00000272198.6_Missense_Mutation_p.I390F|PPFIA4_ENST00000599966.1_Missense_Mutation_p.I390F|PPFIA4_ENST00000414050.2_Missense_Mutation_p.I603F|PPFIA4_ENST00000295706.4_Missense_Mutation_p.I390F|PPFIA4_ENST00000447715.2_Missense_Mutation_p.I874F			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	390					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CCAGCGGGAGATCGGCATCAG	0.632000													21	88					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143586715	143586715	+	Silent	SNP	C	C	T	rs147117374		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:143586715C>T	ENST00000507359.2	+	2	1529	c.438C>T	c.(436-438)agC>agT	p.S146S	KCTD16_ENST00000512467.1_Silent_p.S146S	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16	146						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			CCCAAGGAAGCGACACAAGAA	0.552000													12	38					0	0	1	0	0
QSOX2	169714	broad.mit.edu	37	9	139101020	139101020	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:139101020C>T	ENST00000358701.5	-	12	1688	c.1651G>A	c.(1651-1653)Gaa>Aaa	p.E551K		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	551					cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		ACGTGGCCTTCATCCCAGCTG	0.577000													18	67					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23518025	23518025	+	Missense_Mutation	SNP	C	C	A	rs62342743		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:23518025C>A	ENST00000296682.3	+	5	519	c.337C>A	c.(337-339)Cgt>Agt	p.R113S		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	113					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGTGGAACAGCGTAAACACCA	0.408000										HNSCC(3;0.000094)			50	127					6.20203e-27	1.07053e-26	1	1	0
SAMD14	201191	broad.mit.edu	37	17	48193255	48193255	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:48193255G>T	ENST00000330175.4	-	6	918	c.601C>A	c.(601-603)Cga>Aga	p.R201R	SAMD14_ENST00000503131.1_Silent_p.R201R	NM_001257359.1	NP_001244288.1	Q8IZD0	SAM14_HUMAN	sterile alpha motif domain containing 14	201										breast(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(3)|prostate(1)|urinary_tract(1)	15						GTGGATGCTCGGCGCAGGGTG	0.682000													16	1					5.03518e-11	6.79921e-11	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:20414379G>A	ENST00000380338.4	-	5	751	c.465C>T	c.(463-465)agC>agT	p.S155S	MLLT3_ENST00000429426.2_Silent_p.S152S|MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S155S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.532000			T	MLL	ALL								3	30					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212295774	212295774	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:212295774G>T	ENST00000342788.4	-	21	2849	c.2539C>A	c.(2539-2541)Cgt>Agt	p.R847S	ERBB4_ENST00000436443.1_Missense_Mutation_p.R847S|ERBB4_ENST00000402597.1_Missense_Mutation_p.R837S	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	847	Protein kinase.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		AAGACATTACGGGCTGCCAAA	0.413000										TSP Lung(8;0.080)			16	90					3.62473e-10	4.70268e-10	1	1	0
ZNF770	54989	broad.mit.edu	37	15	35275509	35275509	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:35275509C>A	ENST00000356321.4	-	3	471	c.127G>T	c.(127-129)Gct>Tct	p.A43S		NM_014106.3	NP_054825.2	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)	29		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		TAGTGCCTAGCTAATTTTGAT	0.373000													6	10					0.00448238	0.00467062	1	1	0
TRPC3	7222	broad.mit.edu	37	4	122825631	122825631	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:122825631C>A	ENST00000264811.5	-	7	2298	c.1880G>T	c.(1879-1881)gGg>gTg	p.G627V	TRPC3_ENST00000513531.1_Missense_Mutation_p.G572V|TRPC3_ENST00000379645.3_Missense_Mutation_p.G700V	NM_003305.2	NP_003296.1	Q13507	TRPC3_HUMAN	transient receptor potential cation channel, subfamily C, member 3	615					axon guidance|phototransduction|platelet activation	integral to plasma membrane	protein binding|store-operated calcium channel activity			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(12)|lung(13)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	51						TTCAGACAACCCAAATATTGA	0.303000													22	11					4.47668e-21	7.28378e-21	1	1	0
WAS	7454	broad.mit.edu	37	X	48547293	48547293	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:48547293C>A	ENST00000376701.4	+	10	1251	c.1176C>A	c.(1174-1176)ccC>ccA	p.P392P		NM_000377.2	NP_000368.1	P42768	WASP_HUMAN	Wiskott-Aldrich syndrome	392	Poly-Pro.				blood coagulation|defense response|epidermis development|immune response|T cell receptor signaling pathway	actin cytoskeleton|cytosol	identical protein binding|small GTPase regulator activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(315;1.27e-10)				GTGGGCCACCCATGccaccac	0.746000			"""Mis, N, F, S"""			lymphoma							5	3					0.217242	0.218342	1	1	0
TAF1	6872	broad.mit.edu	37	X	70598689	70598689	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:70598689G>T	ENST00000449580.1	+	8	1216	c.1165G>T	c.(1165-1167)Gag>Tag	p.E389*	TAF1_ENST00000276072.3_Nonsense_Mutation_p.E410*|TAF1_ENST00000423759.1_Nonsense_Mutation_p.E410*|TAF1_ENST00000373790.4_Nonsense_Mutation_p.E389*			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	389	Protein kinase 1.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				TAGGAAACTTGAGGAAAACAA	0.423000													49	97					9.82405e-12	1.34953e-11	1	1	0
ACSM2A	123876	broad.mit.edu	37	16	20477044	20477044	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:20477044G>A	ENST00000573854.1	+	3	497	c.383G>A	c.(382-384)cGa>cAa	p.R128Q	ACSM2A_ENST00000536134.1_5'UTR|ACSM2A_ENST00000575690.1_Missense_Mutation_p.R128Q|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000424070.1_Missense_Mutation_p.R128Q|ACSM2A_ENST00000417235.2_Missense_Mutation_p.R49Q|ACSM2A_ENST00000396104.2_Missense_Mutation_p.R128Q|ACSM2A_ENST00000219054.6_Missense_Mutation_p.R128Q	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	128					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						GGCTGCATTCGAGCAGGTTGG	0.562000													16	42					0	0	1	0	0
C1QB	713	broad.mit.edu	37	1	22987797	22987797	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:22987797C>A	ENST00000509305.1	+	3	1020	c.674C>A	c.(673-675)aCc>aAc	p.T225N	C1QB_ENST00000314933.6_Missense_Mutation_p.T227N			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	227	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CTGCAGGCCACCGACAAGAAC	0.572000													19	72					2.37509e-13	3.42877e-13	1	1	0
ARHGAP10	79658	broad.mit.edu	37	4	148887931	148887931	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:148887931C>T	ENST00000336498.3	+	18	1896	c.1657C>T	c.(1657-1659)Ctc>Ttc	p.L553F	ARHGAP10_ENST00000414545.2_Missense_Mutation_p.L202F	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	553	Rho-GAP.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		TGTCGCTGCCCTCATGGACTT	0.388000													13	57					0	0	1	0	0
ZIC3	7547	broad.mit.edu	37	X	136649747	136649747	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:136649747G>T	ENST00000287538.5	+	1	1447	c.897G>T	c.(895-897)tgG>tgT	p.W299C	ZIC3_ENST00000370606.3_Missense_Mutation_p.W299C	NM_003413.3	NP_003404.1	O60481	ZIC3_HUMAN	Zic family member 3	299	Nuclear localization signal.				cell differentiation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|large_intestine(3)|liver(1)|lung(18)|ovary(3)|soft_tissue(2)|urinary_tract(1)	37	Acute lymphoblastic leukemia(192;0.000127)					TCTGCTACTGGGAGGAGTGCC	0.607000													15	84					1.99824e-07	2.40394e-07	1	1	0
ANO6	196527	broad.mit.edu	37	12	45742393	45742393	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:45742393G>T	ENST00000320560.8	+	6	928	c.726G>T	c.(724-726)aaG>aaT	p.K242N	ANO6_ENST00000426898.2_3'UTR|ANO6_ENST00000423947.3_Missense_Mutation_p.K263N|ANO6_ENST00000441606.2_Missense_Mutation_p.K224N|ANO6_ENST00000435642.1_Missense_Mutation_p.K242N|ANO6_ENST00000425752.2_Missense_Mutation_p.K242N	NM_001025356.2	NP_001020527.2	Q4KMQ2	ANO6_HUMAN	anoctamin 6	242					activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GGATCTACAAGGCAGCTTTCC	0.398000													26	54					1.68575e-08	2.11118e-08	1	1	0
SLC9A3	6550	broad.mit.edu	37	5	475205	475205	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:475205C>T	ENST00000264938.3	-	16	2303	c.2294G>A	c.(2293-2295)cGc>cAc	p.R765H	SLC9A3_ENST00000514375.1_Missense_Mutation_p.R756H|CTD-2228K2.7_ENST00000607286.1_RNA	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	765						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CAGGAGGCTGCGGTCCAGGGC	0.682000													3	60					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40747103	40747103	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:40747103C>A	ENST00000373198.3	-	22	3223	c.2988G>T	c.(2986-2988)atG>atT	p.M996I	PTPRT_ENST00000373184.1_Missense_Mutation_p.M964I|PTPRT_ENST00000356100.2_Missense_Mutation_p.M983I|PTPRT_ENST00000373193.3_Missense_Mutation_p.M977I|PTPRT_ENST00000373201.1_Missense_Mutation_p.M964I|PTPRT_ENST00000373190.1_Missense_Mutation_p.M973I|PTPRT_ENST00000373187.1_Missense_Mutation_p.M974I	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	974	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTGCCAGATCATTCTCCAAA	0.537000													46	59					4.02871e-13	5.77399e-13	1	1	0
UGT2B28	54490	broad.mit.edu	37	4	70156385	70156385	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:70156385C>G	ENST00000335568.5	+	5	1168	c.1166C>G	c.(1165-1167)cCt>cGt	p.P389R	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	389					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	CATGGGATCCCTATGGTAGGC	0.443000													16	78					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625877	29625877	+	Missense_Mutation	SNP	G	G	A	rs7266938	by1000genomes	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:29625877G>A	ENST00000278882.3	+	5	501	c.121G>A	c.(121-123)Gcc>Acc	p.A41T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A41T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A46T														p.A41T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTACAGAATCGCCCTGAAATC	0.358000													5	45					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128351612	128351612	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:128351612C>A	ENST00000262462.4	+	5	2014	c.1004C>A	c.(1003-1005)gCa>gAa	p.A335E	SLC27A6_ENST00000506176.1_Missense_Mutation_p.A335E|SLC27A6_ENST00000395266.1_Missense_Mutation_p.A335E			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	335					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		GTGCGTTTGGCAATTGGAAAT	0.328000													10	38					0.00136819	0.00144078	1	1	0
XK	7504	broad.mit.edu	37	X	37545435	37545435	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:37545435T>G	ENST00000378616.3	+	1	424	c.221T>G	c.(220-222)cTg>cGg	p.L74R	TM4SF2_ENST00000465127.1_Intron	NM_021083.2	NP_066569.1	P51811	XK_HUMAN	X-linked Kx blood group (McLeod syndrome)	74					amino acid transport	integral to membrane	protein binding|transporter activity			breast(1)|endometrium(4)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		all_lung(315;0.175)				CTGCTGCACCTGCTGCAACTT	0.647000													5	12					0	0	1	0	0
DDX53	168400	broad.mit.edu	37	X	23018323	23018323	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:23018323C>A	ENST00000327968.5	+	1	237	c.149C>A	c.(148-150)cCa>cAa	p.P50Q	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	50	KH.					nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						CGTGAACCACCACTCTGCTTT	0.502000													25	33					9.04412e-07	1.06543e-06	1	1	0
ZCCHC5	203430	broad.mit.edu	37	X	77912669	77912669	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:77912669C>A	ENST00000321110.1	-	2	1544	c.1249G>T	c.(1249-1251)Gct>Tct	p.A417S		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	417							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						TGGTTTTCAGCTGGTGGACTC	0.517000													70	66					7.2426e-40	1.30696e-39	1	1	0
DCAF8L1	139425	broad.mit.edu	37	X	27998829	27998829	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:27998829C>G	ENST00000441525.1	-	1	737	c.623G>C	c.(622-624)gGc>gCc	p.G208A		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	208										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						CAGTCGGGTGCCACGCTGGTT	0.532000													10	16					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56020466	56020466	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:56020466G>T	ENST00000303059.3	+	1	791	c.791G>T	c.(790-792)aGg>aTg	p.R264M		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					GCTAAGGGAAGGCAAAAGGCC	0.413000													34	76					6.53348e-20	1.05439e-19	1	1	0
OGDHL	55753	broad.mit.edu	37	10	50954876	50954876	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr10:50954876C>T	ENST00000374103.4	-	10	1301	c.1216G>A	c.(1216-1218)Gtg>Atg	p.V406M	OGDHL_ENST00000432695.1_Missense_Mutation_p.V197M|OGDHL_ENST00000419399.1_Missense_Mutation_p.V349M	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	406					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TCATATACCACGCCCTGGCCA	0.627000													6	29					0	0	1	0	0
LPAR2	9170	broad.mit.edu	37	19	19737900	19737900	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:19737900T>G	ENST00000542587.1	-	5	1096	c.194A>C	c.(193-195)cAg>cCg	p.Q65P	LPAR2_ENST00000586703.1_Missense_Mutation_p.Q65P|LPAR2_ENST00000407877.3_Missense_Mutation_p.Q65P			Q9HBW0	LPAR2_HUMAN	lysophosphatidic acid receptor 2	65					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration	cell surface|integral to plasma membrane	LIM domain binding|lipid binding			breast(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	10						GTAGATGGGCTGGTGGAAGCG	0.642000													5	5					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760594	92760594	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:92760594C>A	ENST00000318238.4	-	5	5907	c.4691G>T	c.(4690-4692)aGa>aTa	p.R1564I	SAMD9L_ENST00000411955.1_Missense_Mutation_p.R1564I|SAMD9L_ENST00000437805.1_Missense_Mutation_p.R1564I	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1564										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GAAAGACACTCTTTCTATGTT	0.348000													6	29					0.0293803	0.0301395	1	1	0
ZNF131	7690	broad.mit.edu	37	5	43174673	43174673	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:43174673G>T	ENST00000509634.1	+	7	1664	c.1208G>T	c.(1207-1209)aGg>aTg	p.R403M	ZNF131_ENST00000399534.1_Missense_Mutation_p.R437M|ZNF131_ENST00000509156.1_Missense_Mutation_p.R437M|ZNF131_ENST00000505606.2_Missense_Mutation_p.R403M|ZNF131_ENST00000306938.4_Missense_Mutation_p.R403M|ZNF131_ENST00000509931.1_Intron			P52739	ZN131_HUMAN	zinc finger protein 131	437						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						GAATTAAGGAGGCATCTCAGT	0.393000													60	58					3.13743e-37	5.61063e-37	1	1	0
COL6A3	1293	broad.mit.edu	37	2	238296691	238296691	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:238296691C>A	ENST00000295550.4	-	4	1298	c.846G>T	c.(844-846)ggG>ggT	p.G282G	COL6A3_ENST00000409809.1_Silent_p.G76G|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000392003.2_Intron|COL6A3_ENST00000392004.3_Silent_p.G76G|COL6A3_ENST00000353578.4_Silent_p.G76G|COL6A3_ENST00000347401.3_Intron|COL6A3_ENST00000346358.4_Silent_p.G282G	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	282	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ACTGGACCACCCCCACTCGGA	0.517000													23	49					3.73988e-18	5.91527e-18	1	1	0
NUF2	83540	broad.mit.edu	37	1	163318841	163318841	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:163318841G>T	ENST00000271452.3	+	13	1510	c.1231G>T	c.(1231-1233)Gct>Tct	p.A411S	NUF2_ENST00000524800.1_Missense_Mutation_p.A364S|NUF2_ENST00000367900.3_Missense_Mutation_p.A411S	NM_145697.2	NP_663735.2	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	411	Interaction with the C-terminus of NDC80 and the SPBC24-SPBC25 subcomplex.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	all_hematologic(923;0.101)					ACTAAAAGATGCTGCTGAAAG	0.313000													18	17					3.62473e-10	4.70268e-10	1	1	0
FHL5	9457	broad.mit.edu	37	6	97063599	97063599	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:97063599A>G	ENST00000326771.2	+	7	1186	c.806A>G	c.(805-807)aAg>aGg	p.K269R	FHL5_ENST00000541107.1_Missense_Mutation_p.K269R	NM_020482.4	NP_065228.4	Q5TD97	FHL5_HUMAN	four and a half LIM domains 5	269	LIM zinc-binding 4.					nucleus	zinc ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|urinary_tract(1)	27		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		ACCCAGAACAAGGAAATCTTC	0.468000													4	34					0	0	1	0	0
PRKCH	5583	broad.mit.edu	37	14	62016507	62016507	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:62016507G>A	ENST00000332981.5	+	14	2395	c.2010G>A	c.(2008-2010)gaG>gaA	p.E670E	RP11-47I22.4_ENST00000556347.1_Intron|PRKCH_ENST00000555082.1_Silent_p.E509E|PRKCH_ENST00000556245.1_3'UTR	NM_006255.3	NP_006246.2	P24723	KPCL_HUMAN	protein kinase C, eta	670	AGC-kinase C-terminal.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity	p.E670E(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(4)|ovary(2)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		ACCAGGATGAGTTTAGAAACT	0.438000													12	30					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55522550	55522550	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:55522550C>T	ENST00000219070.4	+	6	1437	c.928C>T	c.(928-930)Cgc>Tgc	p.R310C	MMP2_ENST00000437642.2_Missense_Mutation_p.R260C|MMP2_ENST00000543485.1_Missense_Mutation_p.R234C|MMP2_ENST00000570308.1_Missense_Mutation_p.R234C	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	310	Collagen-binding.|Fibronectin type-II 2.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding	p.R310C(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	CACTGAGGGCCGCACGGATGG	0.617000													7	16					0	0	1	0	0
CSN2	1447	broad.mit.edu	37	4	70823321	70823321	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:70823321G>C	ENST00000353151.3	-	5	357	c.346C>G	c.(346-348)Cct>Gct	p.P116A		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	116					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						TTAAGGACAGGCATCACTCTG	0.488000													5	47					0	0	1	0	0
AMELX	265	broad.mit.edu	37	X	11316934	11316934	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:11316934C>A	ENST00000380712.3	+	6	521	c.453C>A	c.(451-453)caC>caA	p.H151Q	ARHGAP6_ENST00000337414.4_Intron|ARHGAP6_ENST00000413512.3_Intron|AMELX_ENST00000348912.4_Missense_Mutation_p.H121Q|ARHGAP6_ENST00000380736.1_Intron|AMELX_ENST00000380714.3_Missense_Mutation_p.H137Q|ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000380732.3_Intron	NM_182680.1	NP_872621.1	Q99217	AMELX_HUMAN	amelogenin, X-linked	137					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel			endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						CACAGCCTCACCAGCCCATGC	0.672000													12	41					4.93089e-13	7.0416e-13	1	1	0
C9orf172	389813	broad.mit.edu	37	9	139740228	139740228	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:139740228C>A	ENST00000436881.1	+	1	1362	c.1362C>A	c.(1360-1362)gcC>gcA	p.A454A		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	454										endometrium(2)|large_intestine(1)|lung(6)	9						ACATTCTGGCCCCGGGGCCGC	0.751000													2	2					1	1	1	1	0
FIGN	55137	broad.mit.edu	37	2	164466137	164466137	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:164466137C>A	ENST00000333129.3	-	3	2519	c.2205G>T	c.(2203-2205)aaG>aaT	p.K735N	FIGN_ENST00000409634.1_Intron	NM_018086.2	NP_060556.2	Q5HY92	FIGN_HUMAN	fidgetin	735						nuclear matrix	ATP binding|nucleoside-triphosphatase activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(23)|ovary(1)|prostate(2)|skin(1)	47						TAGGCTGAATCTTGCAGAAAG	0.423000													10	60					0.000978159	0.00104671	1	1	0
C20orf166-AS1	253868	broad.mit.edu	37	20	61143577	61143577	+	RNA	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:61143577G>A	ENST00000475015.1	-	0	761				C20orf166-AS1_ENST00000412495.1_RNA																							AGGGGATTGGGATGCCGCCTG	0.652000													15	29					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17744497	17744497	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:17744497C>A	ENST00000380060.3	+	6	2546	c.2208C>A	c.(2206-2208)gcC>gcA	p.A736A	NHS_ENST00000398097.3_Silent_p.A580A	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	736						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					CAAGCATGGCCACTTATGACA	0.512000													49	48					3.19069e-20	5.17021e-20	1	1	0
FBN2	2201	broad.mit.edu	37	5	127627283	127627283	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:127627283C>A	ENST00000508053.1	-	55	7204	c.6230G>T	c.(6229-6231)gGg>gTg	p.G2077V	FBN2_ENST00000262464.4_Missense_Mutation_p.G2077V			P35556	FBN2_HUMAN	fibrillin 2	2077	EGF-like 35; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTGGAAGCCCCCTGGAGTATT	0.443000													48	24					8.78508e-14	1.28697e-13	1	1	0
AMY2B	280	broad.mit.edu	37	1	104116893	104116893	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:104116893G>T	ENST00000361355.4	+	7	1372	c.756G>T	c.(754-756)ctG>ctT	p.L252L	AMY2B_ENST00000491397.1_3'UTR	NM_020978.3	NP_066188.1	P19961	AMY2B_HUMAN	amylase, alpha 2B (pancreatic)	252					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding			breast(1)|endometrium(7)|kidney(4)|large_intestine(1)|lung(30)|prostate(1)|skin(1)|urinary_tract(1)	46		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		TAATTGATCTGGGTGGTGAGC	0.348000													22	125					6.44725e-10	8.33733e-10	1	1	0
CD163	9332	broad.mit.edu	37	12	7639558	7639558	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:7639558G>T	ENST00000359156.4	-	9	2277	c.2075C>A	c.(2074-2076)tCg>tAg	p.S692*	CD163_ENST00000541972.1_Nonsense_Mutation_p.S680*|CD163_ENST00000396620.3_Nonsense_Mutation_p.S725*|CD163_ENST00000432237.2_Nonsense_Mutation_p.S692*	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	692					acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity	p.S692*(1)		breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						TGAATTGCACGAGGACAGTGT	0.438000													91	15					1.09905e-38	1.9743e-38	1	1	0
MYCBP2	23077	broad.mit.edu	37	13	77656071	77656071	+	Silent	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr13:77656071G>C	ENST00000407578.2	-	64	11360	c.11094C>G	c.(11092-11094)gtC>gtG	p.V3698V	MYCBP2-AS1_ENST00000450627.2_RNA|MYCBP2_ENST00000357337.6_Silent_p.V3660V|MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2-AS1_ENST00000448470.2_RNA|MYCBP2_ENST00000544440.2_Silent_p.V3660V|MYCBP2-AS1_ENST00000422231.2_RNA	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3660	DOC.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGTGATGAAAGACGTTGCTCT	0.368000													15	62					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70319439	70319439	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:70319439G>A	ENST00000338508.4	-	33	5087	c.5088C>T	c.(5086-5088)ccC>ccT	p.P1696P	SHANK2_ENST00000409161.1_Silent_p.P1099P|SHANK2_ENST00000423696.2_Silent_p.P1316P|SHANK2_ENST00000449833.2_Silent_p.P1100P			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1316					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTTCATAGTCGGGGGGCCGGC	0.627000													9	43					0	0	1	0	0
RCHY1	25898	broad.mit.edu	37	4	76416960	76416960	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:76416960G>A	ENST00000324439.5	-	6	881	c.483C>T	c.(481-483)gtC>gtT	p.V161V	RCHY1_ENST00000451788.1_Silent_p.V161V|RCHY1_ENST00000512706.1_Silent_p.V139V|RCHY1_ENST00000513257.1_Silent_p.V161V|RCHY1_ENST00000380840.2_Silent_p.V121V	NM_001278536.1|NM_001278538.1|NM_001278539.1	NP_001265465.1|NP_001265467.1|NP_001265468.1	Q96PM5	ZN363_HUMAN	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase	161					positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein autoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nuclear speck|ubiquitin ligase complex	electron carrier activity|p53 binding|protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|pancreas(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CACATGGCAAGACATGAGCAA	0.303000													6	27					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25168432	25168432	+	RNA	SNP	T	T	C	rs149337771	by1000genomes	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr13:25168432T>C	ENST00000453498.1	+	0	1104																											TTGAAACAGCTGGTGTATTAA	0.373000													3	35					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117783531	117783531	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:117783531G>T	ENST00000350763.4	-	28	6922	c.6511C>A	c.(6511-6513)Cac>Aac	p.H2171N	TNC_ENST00000535648.1_Missense_Mutation_p.H1716N|TNC_ENST00000537320.1_Missense_Mutation_p.H1534N|TNC_ENST00000542877.1_Missense_Mutation_p.H1808N|TNC_ENST00000341037.4_Missense_Mutation_p.H1989N|TNC_ENST00000345230.3_Missense_Mutation_p.H1534N|TNC_ENST00000340094.3_Missense_Mutation_p.H1807N|TNC_ENST00000346706.3_Missense_Mutation_p.H1625N|TNC_ENST00000423613.2_Missense_Mutation_p.H1898N	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2171	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						CCCTTCCAGTGGAACCAGTTA	0.468000													12	20					6.72482e-11	9.05002e-11	1	1	0
ZNF33A	7581	broad.mit.edu	37	10	38344866	38344866	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr10:38344866G>T	ENST00000374618.3	+	5	1992	c.1814G>T	c.(1813-1815)gGg>gTg	p.G605V	ZNF33A_ENST00000458705.2_Missense_Mutation_p.G604V|ZNF33A_ENST00000469037.2_Intron|ZNF33A_ENST00000307441.9_Missense_Mutation_p.G604V|ZNF33A_ENST00000432900.2_Missense_Mutation_p.G611V	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	604						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.G604V(1)		cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						ACACATACAGGGGAGAAACCC	0.373000													20	31					7.45023e-12	1.02699e-11	1	1	0
ADAM2	2515	broad.mit.edu	37	8	39646227	39646227	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:39646227G>A	ENST00000265708.4	-	8	706	c.603C>T	c.(601-603)gtC>gtT	p.V201V	ADAM2_ENST00000379853.2_Intron|ADAM2_ENST00000347580.4_Silent_p.V182V|ADAM2_ENST00000521880.1_Silent_p.V201V	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	201	Peptidase M12B.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding	p.V201V(2)		haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTTTTTGAGCGACAACAGTTG	0.289000													6	31					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982324	7982324	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:7982324T>A	ENST00000328600.2	-	2	996	c.835A>T	c.(835-837)Agg>Tgg	p.R279W		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	279	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTATGTCTCCTAATTAGAAGG	0.522000													19	69					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83590845	83590845	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:83590845C>A	ENST00000265362.3	-	17	2472	c.2158G>T	c.(2158-2160)Gag>Tag	p.E720*	SEMA3A_ENST00000436949.1_Nonsense_Mutation_p.E720*	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	720					axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						TCACAGAACTCATCCATTGTG	0.453000													23	41					6.36457e-07	7.5425e-07	1	1	0
ANGPT2	285	broad.mit.edu	37	8	6366501	6366501	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:6366501C>T	ENST00000325203.5	-	8	1756	c.1282G>A	c.(1282-1284)Gga>Aga	p.G428R	ANGPT2_ENST00000415216.1_Missense_Mutation_p.G427R|MCPH1_ENST00000344683.5_Intron|ANGPT2_ENST00000523120.1_Missense_Mutation_p.G427R|ANGPT2_ENST00000338312.6_Missense_Mutation_p.G376R			O15123	ANGP2_HUMAN	angiopoietin 2	428	Fibrinogen C-terminal.				angiogenesis|blood coagulation|leukocyte migration|negative regulation of blood vessel endothelial cell migration|negative regulation of positive chemotaxis|Tie receptor signaling pathway	extracellular space	metal ion binding|receptor tyrosine kinase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17		Hepatocellular(245;0.0663)		Colorectal(4;0.0142)|READ - Rectum adenocarcinoma(4;0.19)|COAD - Colon adenocarcinoma(4;0.226)		TCGTTGTCTCCATCCTTTGTG	0.408000													29	48					0	0	1	0	0
HAPLN2	60484	broad.mit.edu	37	1	156593864	156593864	+	Silent	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:156593864C>G	ENST00000255039.1	+	4	758	c.351C>G	c.(349-351)ggC>ggG	p.G117G	HAPLN2_ENST00000494218.1_3'UTR	NM_021817.2	NP_068589.1	Q9GZV7	HPLN2_HUMAN	hyaluronan and proteoglycan link protein 2	117	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	7	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCATCGCGGGCGTGCGCCTGG	0.692000													10	21					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70608668	70608668	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:70608668G>T	ENST00000449580.1	+	17	2698	c.2647G>T	c.(2647-2649)Gag>Tag	p.E883*	TAF1_ENST00000276072.3_Nonsense_Mutation_p.E904*|TAF1_ENST00000423759.1_Nonsense_Mutation_p.E904*|TAF1_ENST00000373790.4_Nonsense_Mutation_p.E883*			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	883					G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				GGTGTCACCAGAGCAGTGCTG	0.433000													55	54					7.91745e-34	1.39081e-33	1	1	0
PACRGL	133015	broad.mit.edu	37	4	20709442	20709442	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:20709442G>C	ENST00000360916.5	+	4	615	c.224G>C	c.(223-225)cGa>cCa	p.R75P	PACRGL_ENST00000538990.1_Intron|PACRGL_ENST00000444671.2_Intron|PACRGL_ENST00000503585.1_Missense_Mutation_p.R75P|PACRGL_ENST00000507634.1_Missense_Mutation_p.R75P|PACRGL_ENST00000502938.1_Intron|PACRGL_ENST00000295290.8_Missense_Mutation_p.R75P|PACRGL_ENST00000513459.1_Intron|PACRGL_ENST00000502374.1_Intron	NM_145048.3	NP_659485.1	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like	75							binding			endometrium(2)|lung(7)|prostate(1)	10						GAACAGTCACGAGTGCCTTCT	0.348000													8	32					0	0	1	0	0
MID2	11043	broad.mit.edu	37	X	107084433	107084433	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:107084433C>G	ENST00000262843.6	+	2	1086	c.538C>G	c.(538-540)Cgc>Ggc	p.R180G	MID2_ENST00000443968.2_Missense_Mutation_p.R180G	NM_012216.3|NM_052817.2	NP_036348.2|NP_438112.2	Q9UJV3	TRIM1_HUMAN	midline 2	180						centrosome|microtubule	ligase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)	19						CACCAGCCACCGCCTGGTGGA	0.527000													6	49					0	0	1	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603408	140603408	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:140603408G>T	ENST00000239449.4	+	1	331	c.331G>T	c.(331-333)Gaa>Taa	p.E111*	PCDHB14_ENST00000515856.2_Intron	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		111	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGTGGTTTTGGAAAACCCTTT	0.418000													43	35					3.4345e-17	5.34704e-17	1	1	0
SEMA3D	223117	broad.mit.edu	37	7	84727276	84727276	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:84727276G>C	ENST00000284136.6	-	2	200	c.157C>G	c.(157-159)Ctg>Gtg	p.L53V	SEMA3D_ENST00000444867.1_Missense_Mutation_p.L53V	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	53	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TTTGAAAGCAGCAAGTCTATG	0.373000													26	40					0	0	1	0	0
TRIM2	23321	broad.mit.edu	37	4	154197272	154197272	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:154197272A>G	ENST00000338700.5	+	3	508	c.443A>G	c.(442-444)cAc>cGc	p.H148R	TRIM2_ENST00000437508.2_Missense_Mutation_p.H121R|TRIM2_ENST00000494872.1_3'UTR	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	121						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		TGCCCAAACCACGATGGGAAT	0.557000													15	71					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179496014	179496014	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:179496014A>T	ENST00000589042.1	-	237	43985	c.43761T>A	c.(43759-43761)taT>taA	p.Y14587*	TTN_ENST00000591111.1_Nonsense_Mutation_p.Y12946*|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.Y5714*|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.Y5522*|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Nonsense_Mutation_p.Y5647*|TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.Y12019*|TTN-AS1_ENST00000589487.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12946	Fibronectin type-III 5.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCCTGTAAAATATGGGTCTC	0.353000													5	7					0	0	1	0	0
RSBN1	54665	broad.mit.edu	37	1	114354773	114354773	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:114354773G>T	ENST00000261441.5	-	1	325	c.262C>A	c.(262-264)Cag>Aag	p.Q88K		NM_018364.3	NP_060834.2	Q5VWQ0	RSBN1_HUMAN	round spermatid basic protein 1	88						nucleus				breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(3)|urinary_tract(2)	29	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATCGGCGCTGCCGTTTAACT	0.706000													12	34					0.00136819	0.00144078	1	1	0
ANKS1B	56899	broad.mit.edu	37	12	99478745	99478745	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:99478745C>A	ENST00000547776.2	-	16	2582	c.2583G>T	c.(2581-2583)ggG>ggT	p.G861G	ANKS1B_ENST00000546568.1_Silent_p.G87G|ANKS1B_ENST00000547010.1_Silent_p.G437G|ANKS1B_ENST00000550693.2_Silent_p.G87G|ANKS1B_ENST00000332712.7_Silent_p.G87G|ANKS1B_ENST00000329257.7_Silent_p.G861G|ANKS1B_ENST00000549558.2_Silent_p.G87G|ANKS1B_ENST00000547446.1_Silent_p.G56G|ANKS1B_ENST00000549025.2_Silent_p.G30G|ANKS1B_ENST00000546960.1_Silent_p.G87G|ANKS1B_ENST00000549493.2_Silent_p.G87G	NM_152788.4	NP_690001.3	Q7Z6G8	ANS1B_HUMAN	ankyrin repeat and sterile alpha motif domain containing 1B	861	SAM 1.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane				NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(15)|lung(38)|pancreas(1)|prostate(2)|skin(1)	70		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TTTGTCTGTGCCCAGAATTAA	0.388000													5	12					0.0215528	0.022167	1	1	0
TMEM63C	57156	broad.mit.edu	37	14	77685892	77685892	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:77685892C>T	ENST00000298351.4	+	4	346	c.202C>T	c.(202-204)Cgc>Tgc	p.R68C	RP11-463C8.4_ENST00000557752.1_3'UTR	NM_020431.2	NP_065164.2	Q9P1W3	TM63C_HUMAN	transmembrane protein 63C	68						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(1)	23			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0342)		GGACTATGGGCGCCTGGCTCT	0.582000													25	46					0	0	1	0	0
DCHS2	54798	broad.mit.edu	37	4	155225830	155225830	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:155225830G>A	ENST00000357232.3	-	17	4230	c.4231C>T	c.(4231-4233)Cac>Tac	p.H1411Y		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1411	Cadherin 12.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CCAATTATGTGATATTCAACA	0.423000													7	15					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103180650	103180650	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:103180650G>T	ENST00000428762.1	-	44	7083	c.6924C>A	c.(6922-6924)atC>atA	p.I2308I	RELN_ENST00000343529.5_Silent_p.I2308I|RELN_ENST00000424685.2_Silent_p.I2308I	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2308					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGACCTGATCGATAACCCAGG	0.488000													19	50					9.57634e-11	1.28007e-10	1	1	0
CMKLR1	1240	broad.mit.edu	37	12	108686241	108686241	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:108686241C>T	ENST00000312143.7	-	3	862	c.499G>A	c.(499-501)Gct>Act	p.A167T	CMKLR1_ENST00000412676.1_Missense_Mutation_p.A167T|CMKLR1_ENST00000550402.1_Missense_Mutation_p.A167T|CMKLR1_ENST00000552995.1_Missense_Mutation_p.A165T|CMKLR1_ENST00000397688.2_Missense_Mutation_p.A165T	NM_001142344.1|NM_004072.2	NP_001135816.1|NP_004063.1	Q99788	CML1_HUMAN	chemokine-like receptor 1	167					chemotaxis|immune response|negative regulation of interleukin-12 production|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage chemotaxis|regulation of calcium-mediated signaling|skeletal system development	integral to plasma membrane	chemokine receptor activity			endometrium(5)|large_intestine(3)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	37						AAGAAGAAAGCCAGGACCCAG	0.572000													47	59					0	0	1	0	0
GPX7	2882	broad.mit.edu	37	1	53072383	53072383	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:53072383G>T	ENST00000361314.4	+	2	204	c.166G>T	c.(166-168)Gag>Tag	p.E56*	GPX7_ENST00000459779.1_3'UTR	NM_015696.4	NP_056511.2	Q96SL4	GPX7_HUMAN	glutathione peroxidase 7	56					response to oxidative stress	extracellular region	glutathione peroxidase activity			breast(1)|kidney(1)|lung(4)|upper_aerodigestive_tract(1)	7					Glutathione(DB00143)	TGTGGCCAGCGAGTGCGGCTT	0.567000													13	21					2.31682e-05	2.57641e-05	1	1	0
TLL1	7092	broad.mit.edu	37	4	166963182	166963182	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:166963182G>T	ENST00000061240.2	+	11	1912	c.1265G>T	c.(1264-1266)aGa>aTa	p.R422I	TLL1_ENST00000507499.1_Missense_Mutation_p.R422I	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	422	CUB 1.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CTTTTAGGTAGATTCTGTGGG	0.353000													14	19					0.000151284	0.000165911	1	1	0
RERGL	79785	broad.mit.edu	37	12	18234369	18234369	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:18234369C>T	ENST00000229002.2	-	6	580	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	RERGL_ENST00000541632.1_5'UTR|RERGL_ENST00000536890.1_3'UTR|RERGL_ENST00000538724.1_Missense_Mutation_p.R124Q	NM_024730.2	NP_079006.1	Q9H628	RERGL_HUMAN	RERG/RAS-like	125	Small GTPase-like.				signal transduction	membrane	GTP binding|GTPase activity			endometrium(1)|large_intestine(5)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	17						ACAAAGATCTCGTTTGTTGCC	0.408000													17	47					0	0	1	0	0
BMP3	651	broad.mit.edu	37	4	81952571	81952571	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:81952571G>T	ENST00000282701.2	+	1	453	c.133G>T	c.(133-135)Ggc>Tgc	p.G45C		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	45					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						GGCAGGTGGTGGCCCGGACTC	0.667000													6	13					0.000442599	0.000477478	1	1	0
ALDH1A3	220	broad.mit.edu	37	15	101436218	101436218	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:101436218G>T	ENST00000329841.5	+	7	1279	c.747G>T	c.(745-747)caG>caT	p.Q249H	RP11-66B24.4_ENST00000560351.1_RNA|ALDH1A3_ENST00000346623.6_Missense_Mutation_p.Q142H	NM_000693.2	NP_000684.2	P47895	AL1A3_HUMAN	aldehyde dehydrogenase 1 family, member A3	249					retinal metabolic process	cytoplasm	aldehyde dehydrogenase|protein homodimerization activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(7)|lung(9)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	27	Lung NSC(78;0.00144)|all_lung(78;0.0018)|Melanoma(26;0.00852)		OV - Ovarian serous cystadenocarcinoma(32;0.000932)|LUSC - Lung squamous cell carcinoma(107;0.0766)|Lung(145;0.103)		NADH(DB00157)|Vitamin A(DB00162)	CTCACCCTCAGATCAACAAGA	0.547000													14	20					0.000958276	0.00103099	1	1	0
PIH1D3	139212	broad.mit.edu	37	X	106456220	106456220	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:106456220C>A	ENST00000535523.1	+	3	452	c.115C>A	c.(115-117)Ctt>Att	p.L39I	PIH1D3_ENST00000336387.4_Missense_Mutation_p.L39I|PIH1D3_ENST00000372453.3_Missense_Mutation_p.L39I	NM_001169154.1	NP_001162625.1			PIH1 domain containing 3																		CTCTAAGCTACTTAATCCTGA	0.363000													20	59					4.35082e-09	5.55394e-09	1	1	0
SPTLC3	55304	broad.mit.edu	37	20	13055138	13055138	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:13055138T>A	ENST00000399002.2	+	4	874	c.600T>A	c.(598-600)caT>caA	p.H200Q	SPTLC3_ENST00000378194.4_Missense_Mutation_p.H200Q	NM_018327.2	NP_060797.2	Q9NUV7	SPTC3_HUMAN	serine palmitoyltransferase, long chain base subunit 3	200					sphingoid biosynthetic process	integral to membrane|serine C-palmitoyltransferase complex	pyridoxal phosphate binding|serine C-palmitoyltransferase activity|transferase activity, transferring nitrogenous groups			breast(1)|endometrium(1)|large_intestine(7)|lung(14)|skin(1)|urinary_tract(1)	25					Pyridoxal Phosphate(DB00114)	GCACCAGGCATGAAATGGGTA	0.428000													7	128					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123192196	123192196	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:123192196C>T	ENST00000264501.4	+	47	7890	c.7517C>T	c.(7516-7518)cCa>cTa	p.P2506L	KIAA1109_ENST00000455637.1_Missense_Mutation_p.P2506L|KIAA1109_ENST00000388738.3_Missense_Mutation_p.P2506L			Q2LD37	K1109_HUMAN	KIAA1109	2506					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AATCTTCCTCCACTTGAGTTC	0.398000													19	19					0	0	1	0	0
TBC1D8B	54885	broad.mit.edu	37	X	106109122	106109122	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:106109122C>T	ENST00000357242.5	+	16	2695	c.2521C>T	c.(2521-2523)Cag>Tag	p.Q841*	TBC1D8B_ENST00000276175.3_Nonsense_Mutation_p.Q835*	NM_017752.2	NP_060222.2	Q0IIM8	TBC8B_HUMAN	TBC1 domain family, member 8B (with GRAM domain)	841						intracellular	calcium ion binding|Rab GTPase activator activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(6)|liver(4)|lung(15)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						GATTGACTGCCAGCAGTTCAG	0.418000													46	176					0	0	1	0	0
ASAH2	56624	broad.mit.edu	37	10	51974617	51974617	+	Silent	SNP	T	T	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr10:51974617T>C	ENST00000395526.3	-	8	1025	c.1026A>G	c.(1024-1026)gtA>gtG	p.V342V	ASAH2_ENST00000447815.1_Silent_p.V342V|ASAH2_ENST00000329428.6_Silent_p.V323V|ASAH2_ENST00000443575.1_Silent_p.V184V	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	342					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(1)|lung(9)|urinary_tract(1)	11						CAAAGGCTGCTACAAATGGCC	0.428000													9	31					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17698963	17698963	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:17698963C>A	ENST00000399080.2	-	1	743	c.720G>T	c.(718-720)caG>caT	p.Q240H		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	240										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CCAAGCTGGGCTGGTTTTGAG	0.348000													15	33					8.60227e-14	1.26485e-13	1	1	0
REG1P	5969	broad.mit.edu	37	2	79363162	79363162	+	RNA	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:79363162T>A	ENST00000444841.1	-	0	1176																											CCAGGATTTGTAGGAGACCAG	0.517000													5	25					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20586021	20586021	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:20586021C>A	ENST00000315543.4	+	1	456	c.456C>A	c.(454-456)gaC>gaA	p.D152E		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TGGCTTTTGACAGATATGTGG	0.448000													19	38					0.000229342	0.000249448	1	1	0
SLITRK3	22865	broad.mit.edu	37	3	164907271	164907271	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:164907271C>T	ENST00000475390.1	-	2	1791	c.1348G>A	c.(1348-1350)Ggg>Agg	p.G450R	SLITRK3_ENST00000241274.3_Missense_Mutation_p.G450R			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	450						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						ATAAAGGCCCCATCTTGGACA	0.423000										HNSCC(40;0.11)			17	18					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84659884	84659884	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:84659884G>T	ENST00000286744.5	+	23	4115	c.3891G>T	c.(3889-3891)gaG>gaT	p.E1297D	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.E1297D	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	1297	Ig-like C2-type 3.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			CCAAACCAGAGCACAACCATC	0.458000													113	142					4.9668e-63	9.08672e-63	1	1	0
DACH2	117154	broad.mit.edu	37	X	85769308	85769308	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:85769308G>A	ENST00000373131.1	+	2	678	c.515G>A	c.(514-516)cGt>cAt	p.R172H	DACH2_ENST00000373125.4_Missense_Mutation_p.R185H|DACH2_ENST00000510272.1_5'UTR|DACH2_ENST00000508860.1_Missense_Mutation_p.R18H	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding	p.R185P(1)|p.R172P(1)		breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						CCCCCTAAGCGTTCTTTGGGA	0.438000													7	50					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91642792	91642792	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:91642792G>T	ENST00000373094.1	+	5	4048	c.3203G>T	c.(3202-3204)gGt>gTt	p.G1068V	PCDH11X_ENST00000298274.8_Missense_Mutation_p.G1031V|PCDH11X_ENST00000373088.1_Missense_Mutation_p.G1031V|PCDH11X_ENST00000406881.1_Missense_Mutation_p.G1068V|PCDH11X_ENST00000373097.1_Missense_Mutation_p.G1058V|PCDH11X_ENST00000504220.1_Intron|PCDH11X_ENST00000361655.2_Missense_Mutation_p.G1058V	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1068					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						AGCAGTGATGGTGGACTGGGA	0.527000													24	178					6.19805e-25	1.05606e-24	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77767159	77767159	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:77767159G>T	ENST00000521891.2	+	10	8450	c.8002G>T	c.(8002-8004)Gtg>Ttg	p.V2668L	ZFHX4_ENST00000455469.2_Missense_Mutation_p.V2623L|ZFHX4_ENST00000050961.6_Missense_Mutation_p.V2623L|ZFHX4_ENST00000518282.1_Missense_Mutation_p.V2642L	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2623						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.V2652M(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTTCCGGGCGGTGGGTCCAGC	0.547000										HNSCC(33;0.089)			9	75					0.010729	0.0110634	1	1	0
KLHL4	56062	broad.mit.edu	37	X	86880772	86880772	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:86880772G>C	ENST00000373119.4	+	6	1445	c.1300G>C	c.(1300-1302)Gta>Cta	p.V434L	KLHL4_ENST00000373114.4_Missense_Mutation_p.V434L	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	434						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						ACTTTATGCTGTAGGAGGCAT	0.388000													10	68					0	0	1	0	0
FOXN4	121643	broad.mit.edu	37	12	109724502	109724502	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:109724502G>T	ENST00000299162.5	-	7	748	c.644C>A	c.(643-645)cCt>cAt	p.P215H	FOXN4_ENST00000355216.1_Missense_Mutation_p.P35H	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	215					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						CTCGCTCACAGGCAGGCTGCC	0.627000													6	18					0.000157383	0.000171652	1	1	0
GAB2	9846	broad.mit.edu	37	11	77931390	77931390	+	Missense_Mutation	SNP	G	G	T	rs142455789		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:77931390G>T	ENST00000361507.4	-	9	1947	c.1862C>A	c.(1861-1863)cCg>cAg	p.P621Q	GAB2_ENST00000340149.2_Missense_Mutation_p.P583Q	NM_080491.2	NP_536739.1	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2	621					osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity		INTS4/GAB2(2)	NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(8)|ovary(5)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			TGGGGAGCTCGGCTGGAAGTC	0.622000													27	44					1.13719e-10	1.50992e-10	1	1	0
NBPF1	55672	broad.mit.edu	37	1	16918374	16918374	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:16918374G>T	ENST00000430580.2	-	7	1030	c.143C>A	c.(142-144)gCc>gAc	p.A48D		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	48						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CAGGAAGCCGGCCAGTTGAGT	0.433000													20	818					1.96895e-08	2.45809e-08	1	1	0
KCNC1	3746	broad.mit.edu	37	11	17793274	17793274	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:17793274C>A	ENST00000379472.3	+	2	663	c.633C>A	c.(631-633)acC>acA	p.T211T	KCNC1_ENST00000265969.6_Silent_p.T211T	NM_004976.4	NP_004967.1	P48547	KCNC1_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 1	211						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(7)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	33						GCCTGGAGACCCACGAGCGCT	0.587000													16	33					1.3612e-06	1.59881e-06	1	1	0
KCNJ5	3762	broad.mit.edu	37	11	128781289	128781289	+	Missense_Mutation	SNP	C	C	T	rs115012103	byFrequency	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:128781289C>T	ENST00000529694.1	+	2	497	c.121C>T	c.(121-123)Cgc>Tgc	p.R41C	KCNJ5_ENST00000338350.4_Missense_Mutation_p.R41C|KCNJ5_ENST00000533599.1_Missense_Mutation_p.R41C	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	41					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	AGACCGTACGCGCCTGCTGGC	0.592000													23	82					0	0	1	0	0
KLHL34	257240	broad.mit.edu	37	X	21674057	21674057	+	Missense_Mutation	SNP	C	C	A	rs146464429	byFrequency	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:21674057C>A	ENST00000379499.2	-	1	2391	c.1850G>T	c.(1849-1851)cGg>cTg	p.R617L		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	617										cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						CACTGCGCACCGCAGGCCGCT	0.677000													17	11					5.35267e-07	6.38141e-07	1	1	0
DCBLD1	285761	broad.mit.edu	37	6	117824985	117824985	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:117824985G>T	ENST00000338728.5	+	2	288	c.168G>T	c.(166-168)aaG>aaT	p.K56N	DCBLD1_ENST00000368503.4_Missense_Mutation_p.K56N|GOPC_ENST00000467125.1_Intron|DCBLD1_ENST00000296955.8_Missense_Mutation_p.K56N			Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	56	CUB.				cell adhesion	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		TGACATCTAAGAATTATCCCG	0.438000													36	62					2.37825e-27	4.12299e-27	1	1	0
CCDC115	84317	broad.mit.edu	37	2	131096756	131096756	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:131096756C>A	ENST00000259229.2	-	5	703	c.480G>T	c.(478-480)tgG>tgT	p.W160C	CCDC115_ENST00000437688.2_3'UTR|CCDC115_ENST00000409127.1_Missense_Mutation_p.W155C	NM_032357.2	NP_115733.2	Q96NT0	CC115_HUMAN	coiled-coil domain containing 115	160						endosome|lysosome				central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(1)	7	Colorectal(110;0.1)					GGCTTCGACCCCAGTCAATGC	0.602000													11	30					9.31168e-06	1.05924e-05	1	1	0
MYO15A	51168	broad.mit.edu	37	17	18052078	18052078	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:18052078G>A	ENST00000205890.5	+	33	7106	c.6768G>A	c.(6766-6768)ggG>ggA	p.G2256G		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2256	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TCACCAGGGGGCTGGCAGATG	0.582000													4	7					0	0	1	0	0
DCLK3	85443	broad.mit.edu	37	3	36779279	36779279	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:36779279C>A	ENST00000416516.2	-	2	1362	c.872G>T	c.(871-873)cGa>cTa	p.R291L		NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	291						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						CTCTTCTCCTCGGGTCCTGCG	0.552000													26	53					5.60225e-13	7.94319e-13	1	1	0
SLC5A6	8884	broad.mit.edu	37	2	27430475	27430475	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:27430475G>C	ENST00000310574.3	-	3	517	c.44C>G	c.(43-45)tCg>tGg	p.S15W	SLC5A6_ENST00000408041.1_Missense_Mutation_p.S15W	NM_021095.2	NP_066918.2	Q9Y289	SC5A6_HUMAN	solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6	15					biotin metabolic process|pantothenate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent multivitamin transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(8)|ovary(3)|prostate(1)|skin(1)	20	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Biotin(DB00121)|Lipoic Acid(DB00166)	GCTTGTGCCCGAGGTTGGGGA	0.567000													17	36					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32820195	32820195	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:32820195G>T	ENST00000421745.2	+	68	13730	c.13596G>T	c.(13594-13596)atG>atT	p.M4532I		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4532					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					TGGCTGTTATGAAGAAATTAC	0.308000													5	17					0.184627	0.186506	1	1	0
OR4C16	219428	broad.mit.edu	37	11	55339753	55339753	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:55339753C>G	ENST00000314634.3	+	1	150	c.150C>G	c.(148-150)agC>agG	p.S50R		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	50					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				TCAAGACCAGCCAGGCACTTA	0.388000													25	77					0	0	1	0	0
PDSS1	23590	broad.mit.edu	37	10	27031431	27031431	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr10:27031431A>T	ENST00000376203.5	+	9	887	c.841A>T	c.(841-843)Aga>Tga	p.R281*	PDSS1_ENST00000376215.5_Silent_p.P344P|PDSS1_ENST00000470978.1_3'UTR			Q5T2R2	DPS1_HUMAN	prenyl (decaprenyl) diphosphate synthase, subunit 1	0					isoprenoid biosynthetic process|ubiquinone biosynthetic process	mitochondrion	metal ion binding|protein heterodimerization activity			autonomic_ganglia(1)|endometrium(1)|kidney(7)|large_intestine(6)|lung(5)|prostate(1)	21						GTTAGTTCCCAGAAATGAATG	0.343000													11	15					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49669765	49669765	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:49669765C>G	ENST00000561648.1	-	4	3351	c.3298G>C	c.(3298-3300)Gcc>Ccc	p.A1100P	ZNF423_ENST00000562871.1_Missense_Mutation_p.A1040P|ZNF423_ENST00000567169.1_Missense_Mutation_p.A983P|ZNF423_ENST00000562520.1_Missense_Mutation_p.A1040P|ZNF423_ENST00000262383.2_Missense_Mutation_p.A1100P|ZNF423_ENST00000563137.2_Missense_Mutation_p.A1040P|ZNF423_ENST00000535559.1_Missense_Mutation_p.A983P	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	1100					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				TGTCCGTTGGCGCTGCGGGCC	0.697000													13	24					0	0	1	0	0
INTS7	25896	broad.mit.edu	37	1	212156079	212156079	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:212156079C>G	ENST00000366994.3	-	9	1175	c.1071G>C	c.(1069-1071)agG>agC	p.R357S	INTS7_ENST00000440600.2_Missense_Mutation_p.R308S|INTS7_ENST00000366993.3_Missense_Mutation_p.R357S|INTS7_ENST00000366992.3_Missense_Mutation_p.R357S|INTS7_ENST00000469606.1_5'UTR	NM_001199811.1|NM_001199812.1|NM_015434.3	NP_001186740.1|NP_001186741.1|NP_056249.1	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	357					snRNA processing	integrator complex	protein binding			NS(1)|breast(1)|kidney(1)|large_intestine(8)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		CTGCAATGCCCCTGTTATTAT	0.368000													21	80					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55356838	55356838	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:55356838G>A	ENST00000524622.1	-	7	1091	c.430C>T	c.(430-432)Cgc>Tgc	p.R144C	TESPA1_ENST00000532804.1_Missense_Mutation_p.R144C|TESPA1_ENST00000449076.1_Missense_Mutation_p.R282C|TESPA1_ENST00000316577.8_Missense_Mutation_p.R282C|TESPA1_ENST00000531122.1_Missense_Mutation_p.R144C	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	282																	TTCCGAAGGCGGTCTCTGGGT	0.552000													8	40					0	0	1	0	0
ZMYND15	84225	broad.mit.edu	37	17	4647142	4647142	+	Splice_Site	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:4647142G>C	ENST00000433935.1	+	7	1435	c.1378_splice	c.e7+1	p.G460_splice	ZMYND15_ENST00000573751.2_Splice_Site_p.G460_splice|ZMYND15_ENST00000592813.1_Splice_Site_p.V460_splice|ZMYND15_ENST00000269289.6_Splice_Site_p.V460_splice	NM_001136046.2|NM_001267822.1	NP_001129518.1|NP_001254751.1	Q9H091	ZMY15_HUMAN	zinc finger, MYND-type containing 15	459							zinc ion binding			endometrium(5)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)	18						GGGTGTTTTTGGTGAGCTGGA	0.607000													6	13					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110827016	110827016	+	Silent	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr13:110827016T>A	ENST00000375820.4	-	38	3400	c.3279A>T	c.(3277-3279)ccA>ccT	p.P1093P		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1093	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CTGGGGACCCTGGCATTCCTG	0.532000													25	46					0	0	1	0	0
CACNA1I	8911	broad.mit.edu	37	22	40060895	40060895	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr22:40060895T>A	ENST00000336649.4	+	24	3836	c.3836T>A	c.(3835-3837)gTc>gAc	p.V1279D	CACNA1I_ENST00000402142.3_Missense_Mutation_p.V1273D|CACNA1I_ENST00000400164.3_Missense_Mutation_p.V1238D|CACNA1I_ENST00000407673.1_Missense_Mutation_p.V1238D|CACNA1I_ENST00000401624.1_Missense_Mutation_p.V1273D|CACNA1I_ENST00000404898.1_Missense_Mutation_p.V1238D			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	1273					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GTCCTCCGAGTCTTGCGGCTC	0.627000													21	30					0	0	1	0	0
FLRT2	23768	broad.mit.edu	37	14	86089618	86089618	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:86089618A>T	ENST00000330753.4	+	2	2527	c.1760A>T	c.(1759-1761)gAt>gTt	p.D587V	FLRT2_ENST00000554746.1_Missense_Mutation_p.D587V	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	587					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CGGAAAGATGATTATTGCGAG	0.498000													25	63					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111671538	111671538	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:111671538G>T	ENST00000431670.2	+	11	3162	c.2751G>T	c.(2749-2751)atG>atT	p.M917I	PHLDB2_ENST00000412622.1_Missense_Mutation_p.M874I|PHLDB2_ENST00000393923.3_Missense_Mutation_p.M901I|PHLDB2_ENST00000481953.1_Missense_Mutation_p.M874I|PHLDB2_ENST00000495180.1_Intron|PHLDB2_ENST00000393925.3_Missense_Mutation_p.M917I	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	917						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GTGCTACTATGGGGAGAAGCA	0.448000													23	43					1.75199e-13	2.53846e-13	1	1	0
RIN2	54453	broad.mit.edu	37	20	19956407	19956407	+	Missense_Mutation	SNP	T	T	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:19956407T>G	ENST00000255006.6	+	8	2034	c.1885T>G	c.(1885-1887)Tcg>Gcg	p.S629A	RIN2_ENST00000440354.2_Intron|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	580	VPS9.				endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						CCCCATCGAGTCGCTGATCCC	0.473000													3	9					0	0	1	0	0
PARP12	64761	broad.mit.edu	37	7	139741443	139741443	+	Splice_Site	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:139741443C>A	ENST00000263549.3	-	6	2056		c.e6+1		PARP12_ENST00000470515.1_Splice_Site	NM_022750.2	NP_073587.1	Q9H0J9	PAR12_HUMAN	poly (ADP-ribose) polymerase family, member 12							nucleus	NAD+ ADP-ribosyltransferase activity|nucleic acid binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(1)	19	Melanoma(164;0.0142)					ATCACACTTACCTGTCTTCCA	0.488000													31	127					7.11191e-15	1.07764e-14	1	1	0
SLFN5	162394	broad.mit.edu	37	17	33586242	33586242	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:33586242G>T	ENST00000299977.4	+	2	681	c.533G>T	c.(532-534)aGa>aTa	p.R178I	SLFN5_ENST00000592325.1_Missense_Mutation_p.R178I|SLFN5_ENST00000542451.1_Missense_Mutation_p.R178I	NM_144975.3	NP_659412.3	Q08AF3	SLFN5_HUMAN	schlafen family member 5	178					cell differentiation		ATP binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(8)|liver(2)|lung(6)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	34		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		TTATTTGATAGAAAGCGGCTT	0.398000													52	30					3.4597e-24	5.84469e-24	1	1	0
KIAA1244	57221	broad.mit.edu	37	6	138584561	138584561	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:138584561C>G	ENST00000251691.4	+	12	2107	c.1941C>G	c.(1939-1941)tgC>tgG	p.C647W		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	647	SEC7.				regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		CCCGGGACTGCCTAGGCCACC	0.592000													43	74					0	0	1	0	0
ZNF680	340252	broad.mit.edu	37	7	63981936	63981936	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:63981936A>T	ENST00000309683.6	-	4	1347	c.1196T>A	c.(1195-1197)aTt>aAt	p.I399N		NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				TCCAGTATGAATTCTCATATG	0.378000													10	45					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23913291	23913291	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr13:23913291C>G	ENST00000382298.3	-	10	5312	c.4724G>C	c.(4723-4725)cGg>cCg	p.R1575P	SACS_ENST00000402364.1_Missense_Mutation_p.R825P|SACS_ENST00000382292.3_Missense_Mutation_p.R1575P	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1575			R -> P (in SACS).		cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CATGAATTCCCGACTCATAAT	0.338000													20	34					0	0	1	0	0
KCNK2	3776	broad.mit.edu	37	1	215256771	215256771	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:215256771G>T	ENST00000444842.2	+	1	193	c.43G>T	c.(43-45)Gga>Tga	p.G15*	KCNK2_ENST00000391895.2_Intron|KCNK2_ENST00000391894.2_Intron	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	15							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CTATAGAGCAGGAGGTGAGAC	0.577000													11	81					0.00185496	0.0019482	1	1	0
CNTN1	1272	broad.mit.edu	37	12	41323600	41323600	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:41323600G>A	ENST00000551295.2	+	7	616	c.499G>A	c.(499-501)Gat>Aat	p.D167N	CNTN1_ENST00000547849.1_Missense_Mutation_p.D167N|CNTN1_ENST00000347616.1_Missense_Mutation_p.D167N|CNTN1_ENST00000547702.1_Missense_Mutation_p.D167N|CNTN1_ENST00000348761.2_Missense_Mutation_p.D156N|CNTN1_ENST00000360099.3_Missense_Mutation_p.D167N	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1	167	Ig-like C2-type 2.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TCTCCTAGATGATCTTAGCTA	0.333000													11	24					0	0	1	0	0
LIMK1	3984	broad.mit.edu	37	7	73520557	73520557	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:73520557C>A	ENST00000418310.1	+	7	1057	c.955C>A	c.(955-957)Cgg>Agg	p.R319R	LIMK1_ENST00000538333.3_Silent_p.R255R|LIMK1_ENST00000336180.2_Silent_p.R289R			P53667	LIMK1_HUMAN	LIM domain kinase 1	289					actin cytoskeleton organization|axon guidance|negative regulation of ubiquitin-protein ligase activity|positive regulation of actin filament bundle assembly|positive regulation of axon extension|Rho protein signal transduction	cytosol|growth cone|nucleus	ATP binding|heat shock protein binding|protein serine/threonine kinase activity|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21		Lung NSC(55;0.137)				CAGCTCTGCCCGGCAGAAACC	0.657000													8	174					0.000442599	0.000477478	1	1	0
COL11A1	1301	broad.mit.edu	37	1	103348760	103348760	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:103348760C>A	ENST00000358392.2	-	64	5319	c.5002G>T	c.(5002-5004)Gag>Tag	p.E1668*	COL11A1_ENST00000370096.3_Nonsense_Mutation_p.E1656*|COL11A1_ENST00000353414.4_Nonsense_Mutation_p.E1617*|COL11A1_ENST00000512756.1_Nonsense_Mutation_p.E1540*	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1656	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTTACTCCCTCAGATTTTTTG	0.368000													14	55					2.61681e-11	3.54565e-11	1	1	0
SSPO	23145	broad.mit.edu	37	7	149477086	149477086	+	RNA	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:149477086C>G	ENST00000378016.2	+	0	1263							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GTCTCTTTGCCTACTGCGCAG	0.632000													5	17					0	0	1	0	0
WNT11	7481	broad.mit.edu	37	11	75907590	75907590	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:75907590C>T	ENST00000322563.3	-	2	380	c.256G>A	c.(256-258)Gac>Aac	p.D86N		NM_004626.2	NP_004617.2	O96014	WNT11_HUMAN	wingless-type MMTV integration site family, member 11	86					adrenal gland development|anterior/posterior pattern formation|artery morphogenesis|axis specification|bone mineralization|cellular response to retinoic acid|cloacal septation|embryonic skeletal system development|endoderm development|lung-associated mesenchyme development|mesonephric duct development|negative regulation of apoptosis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cartilage development|negative regulation of cell growth|negative regulation of cell migration|negative regulation of transcription, DNA-dependent|neuroendocrine cell differentiation|neuron differentiation|osteoblast differentiation|outflow tract morphogenesis|palate development|positive regulation of cell migration|positive regulation of protein kinase C signaling cascade|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor-beta2 production|protein localization at cell surface|protein phosphorylation|tight junction assembly|ureteric bud morphogenesis|ventricular septum morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|protein kinase activator activity|Ras GTPase activator activity|transcription regulatory region DNA binding			breast(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20						CAGCGCATGTCGGCAAAGGCC	0.632000													21	152					0	0	1	0	0
CLK4	57396	broad.mit.edu	37	5	178040495	178040495	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:178040495G>C	ENST00000316308.4	-	7	973	c.805C>G	c.(805-807)Cag>Gag	p.Q269E		NM_020666.2	NP_065717.1	Q9HAZ1	CLK4_HUMAN	CDC-like kinase 4	269	Protein kinase.					nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(2)	21	all_cancers(89;0.000969)|Renal(175;0.000159)|all_epithelial(37;0.000451)|Lung NSC(126;0.00545)|all_lung(126;0.00918)	all_cancers(40;0.0272)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.235)		TGGCAGATCTGATACGCCATC	0.333000													20	2					0	0	1	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204242843	204242843	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:204242843T>C	ENST00000272203.3	-	3	329	c.13A>G	c.(13-15)Aca>Gca	p.T5A	PLEKHA6_ENST00000414478.1_Missense_Mutation_p.T5A	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	5										breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			TTCCCACCTGTTTTATTGGAC	0.522000													13	54					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82474784	82474784	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:82474784G>A	ENST00000423517.2	-	13	14186	c.13849C>T	c.(13849-13851)Cca>Tca	p.P4617S	PCLO_ENST00000426442.2_5'UTR|PCLO_ENST00000333891.8_Missense_Mutation_p.P4617S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4505	C2 1.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCAACCCCTGGGGATTTCGCC	0.423000													3	12					0	0	1	0	0
MRAP2	112609	broad.mit.edu	37	6	84765088	84765088	+	Silent	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:84765088T>A	ENST00000257776.4	+	2	186	c.51T>A	c.(49-51)tcT>tcA	p.S17S		NM_138409.2	NP_612418.2	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	17					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(4)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	19						AATCGGCATCTAATTCTGATT	0.403000													13	42					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65145914	65145914	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:65145914C>A	ENST00000381210.3	-	12	1078	c.968G>T	c.(967-969)gGa>gTa	p.G323V	TECRL_ENST00000507440.1_Intron	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	323					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						TGTAAAAATTCCAACTAGAAG	0.264000													6	12					0.0381472	0.0390321	1	1	0
KIAA1211	57482	broad.mit.edu	37	4	57181772	57181772	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:57181772C>A	ENST00000504228.1	+	6	2209	c.2104C>A	c.(2104-2106)Cgg>Agg	p.R702R	KIAA1211_ENST00000264229.6_Silent_p.R702R|KIAA1211_ENST00000541073.1_Silent_p.R695R			Q6ZU35	K1211_HUMAN	KIAA1211	702										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					TCCCAGGGGCCGGTGTGATTC	0.587000													23	45					4.7796e-09	6.06231e-09	1	1	0
LOC645752	645752	broad.mit.edu	37	15	78208916	78208916	+	RNA	SNP	C	C	G	rs56290535	by1000genomes	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:78208916C>G	ENST00000565869.1	+	0	53																											TCCAGATGTTCTCCTCCATCT	0.627000													3	65					0	0	1	0	0
TMEM214	54867	broad.mit.edu	37	2	27258027	27258027	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:27258027G>T	ENST00000238788.9	+	3	438	c.376G>T	c.(376-378)Gaa>Taa	p.E126*	TMEM214_ENST00000404032.3_Nonsense_Mutation_p.E126*	NM_017727.4	NP_060197.4	Q6NUQ4	TM214_HUMAN	transmembrane protein 214	126						integral to membrane	protein binding			kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CCTGCAGAAGGAACTGGACAA	0.542000													3	37					0.115264	0.116734	1	1	0
VWC2L	402117	broad.mit.edu	37	2	215279078	215279078	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:215279078T>A	ENST00000312504.5	+	2	963	c.161T>A	c.(160-162)gTc>gAc	p.V54D	AC107218.3_ENST00000412896.1_RNA|AC107218.3_ENST00000437883.1_RNA|VWC2L_ENST00000427124.1_Missense_Mutation_p.V54D	NM_001080500.2	NP_001073969.1	B2RUY7	VWC2L_HUMAN	von Willebrand factor C domain containing protein 2-like	54	VWFC 1.					extracellular region				breast(1)|endometrium(1)|large_intestine(3)|lung(10)|prostate(1)	16						AAAGGGTGTGTCGATGACAGC	0.468000													6	23					0	0	1	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33527434	33527434	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:33527434G>T	ENST00000504830.1	-	24	4979	c.4644C>A	c.(4642-4644)ttC>ttA	p.F1548L	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.F1463L	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1548	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GTGTCTGGCAGAAACTGGCTG	0.453000										HNSCC(64;0.19)			7	45					0.00307968	0.00321745	1	1	0
ACSL6	23305	broad.mit.edu	37	5	131303681	131303681	+	Silent	SNP	G	G	A	rs144740812		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:131303681G>A	ENST00000379264.2	-	16	1656	c.1548C>T	c.(1546-1548)ctC>ctT	p.L516L	ACSL6_ENST00000543479.1_Silent_p.L491L|AC034228.4_ENST00000446275.1_RNA|ACSL6_ENST00000357096.1_Silent_p.L416L|ACSL6_ENST00000379246.1_Silent_p.L502L|ACSL6_ENST00000379272.2_Silent_p.L506L|ACSL6_ENST00000544770.1_Silent_p.L400L|ACSL6_ENST00000296869.4_Silent_p.L516L|ACSL6_ENST00000379240.1_Silent_p.L491L|ACSL6_ENST00000379249.3_Silent_p.L491L|ACSL6_ENST00000379244.1_Silent_p.L491L|ACSL6_ENST00000379255.1_Silent_p.L416L|ACSL6_ENST00000431707.1_Silent_p.L471L	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	491					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity	p.L516L(1)		NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CAACATCAACGAGCTTGATAT	0.483000													34	35					0	0	1	0	0
EXD3	54932	broad.mit.edu	37	9	140242555	140242555	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:140242555C>A	ENST00000340951.4	-	17	2161	c.1966G>T	c.(1966-1968)Ggc>Tgc	p.G656C	EXD3_ENST00000342129.4_Missense_Mutation_p.G307C	NM_017820.3	NP_060290.3	Q8N9H8	MUT7_HUMAN	exonuclease 3'-5' domain containing 3	656					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)	12						TCACCATTGCCCAGCATGCGT	0.662000													5	28					8.12818e-05	8.96358e-05	1	1	0
XIRP2	129446	broad.mit.edu	37	2	168106147	168106147	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:168106147C>G	ENST00000409195.1	+	9	8334	c.8245C>G	c.(8245-8247)Ctg>Gtg	p.L2749V	XIRP2_ENST00000409273.1_Missense_Mutation_p.L2527V|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.L2749V	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2574					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAAACAATATCTGAAAACCAA	0.353000													6	35					0	0	1	0	0
TPBG	7162	broad.mit.edu	37	6	83075380	83075380	+	Silent	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:83075380C>T	ENST00000369750.3	+	2	1319	c.702C>T	c.(700-702)ccC>ccT	p.P234P	TPBG_ENST00000535040.1_Silent_p.P234P|TPBG_ENST00000543496.1_Silent_p.P234P			Q13641	TPBG_HUMAN	trophoblast glycoprotein	234					cell adhesion	integral to plasma membrane		p.P234P(1)		central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	15		all_cancers(76;0.000805)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0897)		BRCA - Breast invasive adenocarcinoma(397;0.107)		CCCAACTGCCCAGCCTCAGGC	0.622000													17	74					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124540252	124540252	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:124540252C>A	ENST00000296181.4	-	6	1146	c.850G>T	c.(850-852)Gca>Tca	p.A284S	ITGB5_ENST00000488466.1_Intron	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	284	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		CCATCCAATGCGATGTGGGGC	0.547000													35	61					1.30998e-17	2.04749e-17	1	1	0
EWSR1	2130	broad.mit.edu	37	22	29678498	29678498	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr22:29678498G>A	ENST00000397938.2	+	6	852	c.533G>A	c.(532-534)aGc>aAc	p.S178N	EWSR1_ENST00000333395.6_Missense_Mutation_p.S178N|EWSR1_ENST00000414183.2_Missense_Mutation_p.S184N|EWSR1_ENST00000406548.1_Missense_Mutation_p.S178N|EWSR1_ENST00000332035.6_Intron|EWSR1_ENST00000331029.7_Missense_Mutation_p.S178N|EWSR1_ENST00000332050.6_Missense_Mutation_p.S178N	NM_001163285.1|NM_001163286.1|NM_005243.3|NM_013986.3	NP_001156757.1|NP_001156758.1|NP_005234.1|NP_053733.2	Q01844	EWS_HUMAN	EWS RNA-binding protein 1	178	31 X approximate tandem repeats.|EAD (Gln/Pro/Thr-rich).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	calmodulin binding|nucleotide binding|RNA binding|zinc ion binding		EWSR1/ATF1(347)|EWSR1/POU5F1(10)|EWSR1/PBX1(3)|EWSR1/DDIT3(45)|EWSR1/FEV(11)|EWSR1/CREB1(44)|EWSR1/SMARCA5(2)|EWSR1/ETV4(6)|EWSR1/ERG(178)|EWSR1/ZNF384(4)|EWSR1/ETV1(7)|EWSR1/FLI1(2569)|EWSR1/NR4A3(146)|EWSR1/SP3(3)|EWSR1/PATZ1(2)|EWSR1/WT1(234)|EWSR1/NFATC2(9)	breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GTACCTGGGAGCTACCCCATG	0.493000			T	"""FLI1, ERG, ZNF278, NR4A3, FEV, ATF1, ETV1, ETV4, WT1, ZNF384, CREB1, POU5F1,  PBX1"""	"""Ewing sarcoma,  desmoplastic small round cell tumor , ALL, clear cell sarcoma, sarcoma, myoepithelioma"""								3	38					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56815713	56815713	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:56815713C>A	ENST00000229201.4	-	21	2763	c.2609G>T	c.(2608-2610)gGa>gTa	p.G870V	TIMELESS_ENST00000554616.1_Missense_Mutation_p.G368V|TIMELESS_ENST00000553532.1_Missense_Mutation_p.G871V	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	871			M -> V.		cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						GTCAGCCAGTCCCATCTGTAC	0.552000													34	82					7.63091e-17	1.17421e-16	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62292059	62292059	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:62292059T>C	ENST00000378024.4	-	5	10104	c.9830A>G	c.(9829-9831)aAa>aGa	p.K3277R	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3277					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TTTTGGACCTTTTAATTTGGC	0.413000													4	98					0	0	1	0	0
SPINT4	391253	broad.mit.edu	37	20	44352662	44352662	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:44352662C>A	ENST00000279058.3	+	2	276	c.259C>A	c.(259-261)Cgt>Agt	p.R87S		NM_178455.1	NP_848550.1	Q6UDR6	SPIT4_HUMAN	serine peptidase inhibitor, Kunitz type 4	87	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			lung(6)|ovary(1)|skin(1)	8		Myeloproliferative disorder(115;0.028)				TAAAATAGAACGTGAAGTAGC	0.393000													35	54					6.5261e-18	1.02406e-17	1	1	0
ACSM2A	123876	broad.mit.edu	37	16	20482929	20482929	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:20482929G>A	ENST00000573854.1	+	6	926	c.812G>A	c.(811-813)tGc>tAc	p.C271Y	ACSM2A_ENST00000536134.1_Missense_Mutation_p.C43Y|ACSM2A_ENST00000575690.1_Missense_Mutation_p.C271Y|ACSM2A_ENST00000575558.1_3'UTR|ACSM2A_ENST00000417235.2_Missense_Mutation_p.C192Y|ACSM2A_ENST00000396104.2_Missense_Mutation_p.C271Y|ACSM2A_ENST00000219054.6_Missense_Mutation_p.C271Y	NM_001010845.2	NP_001010845.1	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member 2A	271					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(34)|ovary(1)|skin(6)|stomach(1)	51						AACATCTTGTGCTCACTTATG	0.428000													92	120					0	0	1	0	0
GPER1	2852	broad.mit.edu	37	7	1131434	1131434	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:1131434C>T	ENST00000397092.1	+	3	954	c.70C>T	c.(70-72)Ccc>Tcc	p.P24S	C7orf50_ENST00000397098.3_Intron|GPER_ENST00000297469.3_Missense_Mutation_p.P24S|GPER_ENST00000397088.3_Missense_Mutation_p.P24S|C7orf50_ENST00000488073.1_Intron|C7orf50_ENST00000357429.6_Intron|C7orf50_ENST00000397100.2_Intron|GPER_ENST00000401670.1_Missense_Mutation_p.P24S	NM_001039966.1	NP_001035055.1	Q99527	GPER_HUMAN		24						endoplasmic reticulum membrane|Golgi membrane|integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)	13		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;2.32e-16)		GCCTGCGGCCCCCAACACCAC	0.652000													12	42					0	0	1	0	0
OR5D14	219436	broad.mit.edu	37	11	55563382	55563382	+	Silent	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:55563382G>C	ENST00000335605.1	+	1	351	c.351G>C	c.(349-351)ctG>ctC	p.L117L		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				CTTTCTTGCTGGCAGTGATGG	0.502000													14	16					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	32949109	32949109	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:32949109T>C	ENST00000340811.4	-	11	2399	c.2291A>G	c.(2290-2292)cAg>cGg	p.Q764R	PKP2_ENST00000070846.6_Missense_Mutation_p.Q808R	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	808					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					GCGTGCATTCTGGTAACTGTT	0.488000													18	102					0	0	1	0	0
MAPK14	1432	broad.mit.edu	37	6	36040673	36040673	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:36040673G>C	ENST00000229795.3	+	4	776	c.329G>C	c.(328-330)gGg>gCg	p.G110A	MAPK14_ENST00000229794.4_Missense_Mutation_p.G110A|MAPK14_ENST00000468133.1_Missense_Mutation_p.G33A|MAPK14_ENST00000310795.4_Missense_Mutation_p.G110A	NM_001315.2	NP_001306.1	Q16539	MK14_HUMAN	mitogen-activated protein kinase 14	110	Protein kinase.				activation of MAPK activity|cellular component movement|cellular response to ionizing radiation|chemotaxis|innate immune response|mRNA metabolic process|muscle cell differentiation|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of muscle cell differentiation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|signal transduction in response to DNA damage|stress-activated MAPK cascade|stress-induced premature senescence|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|MAP kinase kinase activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|skin(1)|stomach(1)	16						CATCTCATGGGGGCAGATCTG	0.368000													8	29					0	0	1	0	0
NCAPH	23397	broad.mit.edu	37	2	97031718	97031718	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:97031718G>T	ENST00000455200.1	+	14	2065	c.1770G>T	c.(1768-1770)caG>caT	p.Q590H	NCAPH_ENST00000240423.4_Missense_Mutation_p.Q601H|NCAPH_ENST00000427946.1_Missense_Mutation_p.Q465H			Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	601					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(717;0.0221)				CAGCACAACAGAATGGTGACA	0.468000													19	115					1.50039e-11	2.04692e-11	1	1	0
GNL3L	54552	broad.mit.edu	37	X	54578128	54578128	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:54578128C>A	ENST00000336470.4	+	11	1130	c.991C>A	c.(991-993)Cct>Act	p.P331T	GNL3L_ENST00000360845.2_Missense_Mutation_p.P331T	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	331					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						GCTGGCAGACCCTGTGACCCC	0.622000													10	20					0.00136819	0.00144078	1	1	0
HIVEP2	3097	broad.mit.edu	37	6	143093732	143093732	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:143093732C>A	ENST00000367603.2	-	5	2886	c.2144G>T	c.(2143-2145)aGc>aTc	p.S715I	HIVEP2_ENST00000367604.1_Missense_Mutation_p.S715I|HIVEP2_ENST00000012134.2_Missense_Mutation_p.S715I	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	715					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GCTTACAATGCTGCTGCAGAT	0.522000													18	83					2.4624e-09	3.16366e-09	1	1	0
SCG2	7857	broad.mit.edu	37	2	224463548	224463548	+	Silent	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:224463548A>G	ENST00000305409.2	-	2	685	c.453T>C	c.(451-453)taT>taC	p.Y151Y		NM_003469.4	NP_003460.2	P13521	SCG2_HUMAN	secretogranin II	151					angiogenesis|endothelial cell migration|eosinophil chemotaxis|induction of positive chemotaxis|inflammatory response|MAPKKK cascade|negative regulation of apoptosis|negative regulation of endothelial cell proliferation|positive regulation of endothelial cell proliferation|protein secretion	extracellular space|stored secretory granule	chemoattractant activity|cytokine activity			NS(1)|breast(1)|endometrium(1)|kidney(6)|large_intestine(10)|liver(1)|lung(16)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	44		Renal(207;0.0112)|Lung NSC(271;0.0185)|all_lung(227;0.0271)		Epithelial(121;8.16e-11)|all cancers(144;4.66e-08)|Lung(261;0.00714)|LUSC - Lung squamous cell carcinoma(224;0.008)		GCTGTGTCTCATAATCATCAC	0.413000													46	67					0	0	1	0	0
GALNT6	11226	broad.mit.edu	37	12	51749619	51749619	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:51749619G>A	ENST00000543196.2	-	10	1931	c.1726C>T	c.(1726-1728)Ccc>Tcc	p.P576S	GALNT6_ENST00000356317.3_Missense_Mutation_p.P576S			Q8NCL4	GALT6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)	576	Ricin B-type lectin.				protein O-linked glycosylation	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			endometrium(2)|large_intestine(6)|lung(7)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TCGTCCTTGGGGACCTGGCTA	0.557000													8	35					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105025751	105025751	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:105025751C>A	ENST00000507740.1	+	16	2804	c.2568C>A	c.(2566-2568)acC>acA	p.T856T	RIMS2_ENST00000262231.10_Silent_p.T881T|RIMS2_ENST00000436393.2_Intron|RIMS2_ENST00000406091.3_Silent_p.T1042T	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1104	C2 1.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGACCACCACCCGCTCCAGAT	0.498000										HNSCC(12;0.0054)			23	25					4.72057e-08	5.76636e-08	1	1	0
WSCD2	9671	broad.mit.edu	37	12	108589747	108589747	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:108589747G>T	ENST00000332082.4	+	3	956	c.138G>T	c.(136-138)tcG>tcT	p.S46S	WSCD2_ENST00000549903.1_Silent_p.S46S|WSCD2_ENST00000547525.1_Silent_p.S46S|WSCD2_ENST00000261400.3_Silent_p.S46S			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	46						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						CCGCTGTCTCGGGGAACCAGG	0.617000													69	96					3.58576e-35	6.38362e-35	1	1	0
ITGB8	3696	broad.mit.edu	37	7	20449323	20449323	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:20449323C>G	ENST00000222573.3	+	13	2793	c.2109C>G	c.(2107-2109)atC>atG	p.I703M	ITGB8_ENST00000537992.1_Missense_Mutation_p.I568M	NM_002214.2	NP_002205.1	P26012	ITB8_HUMAN	integrin, beta 8	703					cell-matrix adhesion|integrin-mediated signaling pathway|placenta blood vessel development	integrin complex	protein binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(17)|prostate(2)|skin(4)|stomach(2)|urinary_tract(1)	37						AAGTCCTGATCATTAGACAGG	0.333000													19	73					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53085023	53085023	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:53085023A>T	ENST00000276480.7	-	10	1081	c.398T>A	c.(397-399)tTg>tAg	p.L133*		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	133						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AAATTTCCCCAAGTGCATTAA	0.383000													22	22					0	0	1	0	0
TMEM45A	55076	broad.mit.edu	37	3	100277279	100277279	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:100277279G>T	ENST00000403410.1	+	6	1102	c.482G>T	c.(481-483)cGg>cTg	p.R161L	TMEM45A_ENST00000323523.4_Missense_Mutation_p.R145L			Q9NWC5	TM45A_HUMAN	transmembrane protein 45A	145						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)	11						ACTCATGGCCGGGAAATGCTG	0.483000													6	88					0.00198382	0.00207804	1	1	0
GFRAL	389400	broad.mit.edu	37	6	55223787	55223787	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:55223787C>T	ENST00000340465.2	+	6	889	c.803C>T	c.(802-804)aCt>aTt	p.T268I		NM_207410.2	NP_997293.2	Q6UXV0	GFRAL_HUMAN	GDNF family receptor alpha like	268						integral to membrane	receptor activity			NS(1)|breast(1)|endometrium(2)|kidney(5)|large_intestine(2)|liver(1)|lung(31)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	48	Lung NSC(77;0.0875)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CAGGACCTCACTTGTTCAGGA	0.438000													31	60					0	0	1	0	0
DZIP3	9666	broad.mit.edu	37	3	108363053	108363053	+	Missense_Mutation	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:108363053A>G	ENST00000361582.3	+	14	1414	c.1184A>G	c.(1183-1185)cAt>cGt	p.H395R	DZIP3_ENST00000463306.1_Missense_Mutation_p.H395R	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	395					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TATTTCTATCATCTGCTTCAT	0.308000													6	24					0	0	1	0	0
DDX24	57062	broad.mit.edu	37	14	94527356	94527356	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:94527356G>A	ENST00000330836.5	-	4	1431	c.1300C>T	c.(1300-1302)Ctg>Ttg	p.L434L	DDX24_ENST00000544005.1_Silent_p.L184L|DDX24_ENST00000555054.1_Silent_p.L391L	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	434	Helicase ATP-binding.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CGACGGTTCAGCATCCTCTGC	0.448000													21	51					0	0	1	0	0
ZNF530	348327	broad.mit.edu	37	19	58118185	58118185	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:58118185G>T	ENST00000332854.6	+	3	1512	c.1292G>T	c.(1291-1293)gGa>gTa	p.G431V	ZNF530_ENST00000597864.1_Intron	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	431					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTTCACACTGGAGAAAGGCCT	0.433000													29	54					4.74835e-14	7.03394e-14	1	1	0
GALNT3	2591	broad.mit.edu	37	2	166621499	166621499	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:166621499T>C	ENST00000392701.3	-	3	1358	c.583A>G	c.(583-585)Aat>Gat	p.N195D		NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	195	Catalytic subdomain A.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						CACGCTTCATTATGAAAAACT	0.413000													10	45					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027156	37027156	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:37027156C>G	ENST00000358047.3	+	1	725	c.673C>G	c.(673-675)Cag>Gag	p.Q225E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	225										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						TCTCCGCCCACAGCCTCCCAA	0.647000													4	95					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53547495	53547495	+	Silent	SNP	A	A	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:53547495A>G	ENST00000025008.5	-	20	4949	c.4426T>C	c.(4426-4428)Tta>Cta	p.L1476L	RB1CC1_ENST00000435644.2_Silent_p.L1476L|RB1CC1_ENST00000539297.1_Silent_p.L1476L|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1476					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CTTTGATTTAACCGTTTATTT	0.303000													6	18					0	0	1	0	0
OR10A2	341276	broad.mit.edu	37	11	6891885	6891885	+	Silent	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:6891885C>T	ENST00000307322.4	+	1	962	c.900C>T	c.(898-900)aaC>aaT	p.N300N		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		CCCTCAGAAACTGTATCCCAT	0.453000													10	33					0	0	1	0	0
AREL1	9870	broad.mit.edu	37	14	75134250	75134250	+	Silent	SNP	C	C	G	rs139207671	by1000genomes	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:75134250C>G	ENST00000356357.4	-	16	2477	c.1962G>C	c.(1960-1962)gcG>gcC	p.A654A	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		AGATTTTATTCGCATTGGTGA	0.448000													14	23					0	0	1	0	0
CHRM5	1133	broad.mit.edu	37	15	34355468	34355468	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:34355468C>A	ENST00000383263.5	+	3	1220	c.550C>A	c.(550-552)Cag>Aag	p.Q184K	CHRM5_ENST00000557872.1_Missense_Mutation_p.Q184K	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	184					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	GGATGAGTGCCAGATCCAGTT	0.532000													15	115					0.00498961	0.00518554	1	1	0
GABRA3	2556	broad.mit.edu	37	X	151533000	151533000	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:151533000C>G	ENST00000370314.4	-	2	281	c.43G>C	c.(43-45)Ggg>Cgg	p.G15R	GABRA3_ENST00000370311.1_Missense_Mutation_p.G15R|GABRA3_ENST00000535043.1_Missense_Mutation_p.G15R	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	15					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AAAAGAATCCCAAGGCTGGTC	0.448000													20	77					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74623070	74623070	+	Missense_Mutation	SNP	A	A	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:74623070A>C	ENST00000321288.5	+	15	2132	c.2132A>C	c.(2131-2133)cAt>cCt	p.H711P	CCDC33_ENST00000558821.1_Missense_Mutation_p.H101P|CCDC33_ENST00000398814.3_Missense_Mutation_p.H508P|CCDC33_ENST00000268082.4_Missense_Mutation_p.H101P			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	711							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AGGGTGCAGCATTTGCAGAAT	0.577000													10	67					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112605160	112605160	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:112605160C>A	ENST00000550722.1	-	72	12452	c.12057G>T	c.(12055-12057)gcG>gcT	p.A4019A	HECTD4_ENST00000430131.2_Silent_p.A3743A|HECTD4_ENST00000377560.5_Silent_p.A3993A	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGAGGATATCCGCTTCCTGCA	0.617000													31	64					1.42033e-22	2.34947e-22	1	1	0
C7orf33	202865	broad.mit.edu	37	7	148311372	148311372	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:148311372C>G	ENST00000307003.2	+	2	804	c.443C>G	c.(442-444)aCa>aGa	p.T148R		NM_145304.2	NP_660347.1	Q8WU49	CG033_HUMAN	chromosome 7 open reading frame 33	148										central_nervous_system(1)|large_intestine(4)|lung(7)|prostate(2)	14	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AGGACAGTGACAAGTTCATAC	0.483000													30	44					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60042681	60042681	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:60042681C>A	ENST00000397786.2	-	20	4606	c.4530G>T	c.(4528-4530)gcG>gcT	p.A1510A		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1510	Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						TAGTGCTGCTCGCTGCAGATG	0.433000													93	50					7.17885e-55	1.30734e-54	1	1	0
DSCAM	1826	broad.mit.edu	37	21	41416154	41416154	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr21:41416154C>G	ENST00000400454.1	-	31	5711	c.5234G>C	c.(5233-5235)cGc>cCc	p.R1745P		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1745					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCTGGCATAGCGGTTTCTCGC	0.602000													18	15					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24593414	24593414	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:24593414G>T	ENST00000264463.4	-	2	693	c.186C>A	c.(184-186)ttC>ttA	p.F62L	RP11-116O11.1_ENST00000510391.1_RNA	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	62	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CTTCAAGTAAGAAAAATTGAT	0.373000										HNSCC(23;0.051)			4	191					0.00909568	0.00940361	1	1	0
OR2T27	403239	broad.mit.edu	37	1	248814182	248814182	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:248814182C>A	ENST00000344889.3	-	1	3	c.4G>T	c.(4-6)Gag>Tag	p.E2*		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCTCTGCTCCATAGCTCTG	0.428000													7	31					2.17888e-05	2.42982e-05	1	1	0
SRPK3	26576	broad.mit.edu	37	X	153047046	153047046	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:153047046G>C	ENST00000489426.1	+	9	2844	c.478G>C	c.(478-480)Gtc>Ctc	p.V160L	SRPK3_ENST00000370108.3_Missense_Mutation_p.V93L|SRPK3_ENST00000370101.3_Missense_Mutation_p.V93L|SRPK3_ENST00000393786.3_Missense_Mutation_p.V93L|SRPK3_ENST00000370100.1_Missense_Mutation_p.V51L|SRPK3_ENST00000370104.1_Missense_Mutation_p.V93L			Q9UPE1	SRPK3_HUMAN	SRSF protein kinase 3	93	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(2)|pancreas(2)|urinary_tract(1)	13	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTCTCCACCGTCTGGCTCTG	0.662000													8	28					0	0	1	0	0
NSMF	26012	broad.mit.edu	37	9	140349708	140349708	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:140349708G>A	ENST00000371475.3	-	6	993	c.762C>T	c.(760-762)tcC>tcT	p.S254S	NSMF_ENST00000371472.2_Silent_p.S252S|NSMF_ENST00000371473.3_Silent_p.S254S|NSMF_ENST00000339554.3_Silent_p.S51S|NSMF_ENST00000392812.4_Intron|NSMF_ENST00000371474.3_Intron|NSMF_ENST00000265663.7_Silent_p.S252S|NSMF_ENST00000437259.1_Intron	NM_001130969.1	NP_001124441.1			NMDA receptor synaptonuclear signaling and neuronal migration factor																		TTACAGACGCGGAATCATTCT	0.672000													27	78					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136605641	136605641	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:136605641C>A	ENST00000264156.2	-	14	2095	c.2035G>T	c.(2035-2037)Ggt>Tgt	p.G679C	MCM6_ENST00000492091.1_5'UTR	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	679					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	CCACCAGCACCCTCATCTACC	0.438000													17	105					3.7963e-18	5.98069e-18	1	1	0
P2RY14	9934	broad.mit.edu	37	3	150931544	150931544	+	Silent	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:150931544T>A	ENST00000309170.3	-	3	873	c.561A>T	c.(559-561)tcA>tcT	p.S187S	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron|P2RY14_ENST00000424796.2_Silent_p.S187S	NM_001081455.1|NM_014879.3	NP_001074924.1|NP_055694.3	Q15391	P2Y14_HUMAN	purinergic receptor P2Y, G-protein coupled, 14	187						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled|UDP-activated nucleotide receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(1)	20			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AGATGTAGTTTGATGCTTTGT	0.368000													35	63					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36297334	36297334	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:36297334C>A	ENST00000301175.3	-	8	1244	c.1227G>T	c.(1225-1227)caG>caT	p.Q409H		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	409					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGGCCTACCTCTGACTGGTGG	0.577000													10	57					1.49906e-05	1.6907e-05	1	1	0
TTLL11	158135	broad.mit.edu	37	9	124794027	124794027	+	Missense_Mutation	SNP	T	T	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:124794027T>A	ENST00000321582.5	-	3	1125	c.938A>T	c.(937-939)gAc>gTc	p.D313V	TTLL11_ENST00000474723.1_Intron|TTLL11_ENST00000373776.3_Missense_Mutation_p.D313V	NM_001139442.1	NP_001132914.1	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	313	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						CTGGAACTCGTCAGGCAGAAT	0.502000													7	33					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130507126	130507126	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:130507126C>T	ENST00000314830.8	-	7	1630	c.1517G>A	c.(1516-1518)cGa>cAa	p.R506Q	SH2D3C_ENST00000373274.3_Missense_Mutation_p.R346Q|SH2D3C_ENST00000373276.3_Missense_Mutation_p.R438Q|SH2D3C_ENST00000373277.4_Missense_Mutation_p.R349Q|SH2D3C_ENST00000429553.1_Missense_Mutation_p.R152Q|SH2D3C_ENST00000420366.1_Missense_Mutation_p.R348Q|SH2D3C_ENST00000471939.1_5'UTR	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	506					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TGCCCACTCTCGGCTGCCACG	0.642000													10	166					0	0	1	0	0
OC90	729330	broad.mit.edu	37	8	133041363	133041363	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:133041363C>A	ENST00000262283.5	-	17	1830	c.1731G>T	c.(1729-1731)agG>agT	p.R577S	OC90_ENST00000254627.3_Missense_Mutation_p.R365S|OC90_ENST00000603859.1_Missense_Mutation_p.R365S|OC90_ENST00000443356.2_Missense_Mutation_p.R381S			Q02509	OC90_HUMAN	otoconin 90	381					lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			ACCAAGGAAGCCTCTCAAGCA	0.507000													23	92					1.42536e-11	1.95126e-11	1	1	0
TGM6	343641	broad.mit.edu	37	20	2398055	2398055	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:2398055C>A	ENST00000202625.2	+	10	1575	c.1514C>A	c.(1513-1515)cCc>cAc	p.P505H	TGM6_ENST00000381423.1_Missense_Mutation_p.P505H	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	505					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CTAGAGCCTCCCATGCTGGGC	0.657000													5	22					0.217242	0.218342	1	1	0
VGLL1	51442	broad.mit.edu	37	X	135630895	135630895	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:135630895G>T	ENST00000370634.3	+	3	532	c.362G>T	c.(361-363)aGg>aTg	p.R121M		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					TCCCTGGCTAGGAGGGCCTCT	0.607000													48	195					1.19403e-26	2.05208e-26	1	1	0
ITGAD	3681	broad.mit.edu	37	16	31434769	31434769	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:31434769G>T	ENST00000389202.2	+	25	3005	c.2956G>T	c.(2956-2958)Gcc>Tcc	p.A986S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	986					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGTCATGGAGGCCCCATCTCA	0.552000													36	79					4.16155e-14	6.18777e-14	1	1	0
ZFHX4	79776	broad.mit.edu	37	8	77762506	77762506	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:77762506C>A	ENST00000521891.2	+	9	4320	c.3872C>A	c.(3871-3873)cCa>cAa	p.P1291Q	ZFHX4_ENST00000455469.2_Missense_Mutation_p.P1246Q|ZFHX4_ENST00000050961.6_Missense_Mutation_p.P1246Q|ZFHX4_ENST00000518282.1_Missense_Mutation_p.P1265Q	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1246						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GTGATGATGCCAAACAGTATG	0.488000										HNSCC(33;0.089)			5	12					2.7689e-08	3.43516e-08	1	1	0
ANK1	286	broad.mit.edu	37	8	41530129	41530129	+	Silent	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:41530129G>T	ENST00000396942.1	-	38	4922	c.4839C>A	c.(4837-4839)ccC>ccA	p.P1613P	ANK1_ENST00000265709.8_Silent_p.P1654P|ANK1_ENST00000289734.7_Silent_p.P1613P|ANK1_ENST00000396945.1_Silent_p.P1613P|ANK1_ENST00000347528.4_Silent_p.P1613P|ANK1_ENST00000352337.4_Silent_p.P1613P|ANK1_ENST00000379758.2_Silent_p.P1613P			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1613	55 kDa regulatory domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton	p.P1654P(1)|p.P1613P(1)		breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AGCCCAACTCGGGGCCCCGCG	0.567000													20	124					7.45023e-12	1.02699e-11	1	1	0
PRLR	5618	broad.mit.edu	37	5	35070319	35070319	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:35070319G>T	ENST00000382002.5	-	7	1018	c.592C>A	c.(592-594)Cca>Aca	p.P198T	PRLR_ENST00000231423.3_Missense_Mutation_p.P198T|PRLR_ENST00000342362.5_Missense_Mutation_p.P97T|PRLR_ENST00000542609.1_Missense_Mutation_p.P198T|PRLR_ENST00000513753.1_Missense_Mutation_p.P198T|PRLR_ENST00000511486.1_Missense_Mutation_p.P97T|PRLR_ENST00000509934.1_5'UTR|PRLR_ENST00000397391.3_Missense_Mutation_p.P127T|PRLR_ENST00000310101.5_Missense_Mutation_p.P198T|PRLR_ENST00000348262.3_Missense_Mutation_p.P198T	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	198	Fibronectin type-III 2.				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TTCTGTCCTGGATGTAGGCTG	0.443000													12	37					0.00136819	0.00144078	1	1	0
PCLO	27445	broad.mit.edu	37	7	82584021	82584021	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:82584021G>C	ENST00000423517.2	-	5	6585	c.6248C>G	c.(6247-6249)aCc>aGc	p.T2083S	PCLO_ENST00000333891.8_Missense_Mutation_p.T2083S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	2014					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGGGGCCTGGGTTGGGCTAGA	0.463000													4	39					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65145918	65145918	+	Splice_Site	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:65145918C>A	ENST00000381210.3	-	12	1075		c.e12-1		TECRL_ENST00000507440.1_Intron	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like						lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						AAAATTCCAACTAGAAGAAAA	0.269000													3	14					6.4e-05	7.07744e-05	1	1	0
MBD1	4152	broad.mit.edu	37	18	47800235	47800235	+	Splice_Site	SNP	T	T	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr18:47800235T>C	ENST00000591416.1	-	12	1578		c.e12-2		MBD1_ENST00000585672.1_Splice_Site|MBD1_ENST00000585595.1_Splice_Site|MBD1_ENST00000457839.2_Splice_Site|MBD1_ENST00000436910.1_Splice_Site|MBD1_ENST00000424334.2_Splice_Site|MBD1_ENST00000398488.1_Splice_Site|MBD1_ENST00000398493.1_Splice_Site|MBD1_ENST00000398495.2_Splice_Site|MBD1_ENST00000382948.5_Splice_Site|MBD1_ENST00000353909.3_Splice_Site|MBD1_ENST00000349085.2_Splice_Site|MBD1_ENST00000347968.3_Splice_Site|MBD1_ENST00000339998.6_Splice_Site|MBD1_ENST00000269468.5_Splice_Site|MBD1_ENST00000269471.5_Splice_Site|MBD1_ENST00000588937.1_Splice_Site|MBD1_ENST00000587605.1_Splice_Site|MBD1_ENST00000591535.1_Splice_Site|MBD1_ENST00000590208.1_Splice_Site			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1						negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						CAGCCGCTTCTATGGGGAAAG	0.612000													29	24					0	0	1	0	0
FOXP3	50943	broad.mit.edu	37	X	49114015	49114015	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:49114015G>C	ENST00000376207.4	-	4	510	c.323C>G	c.(322-324)aCg>aGg	p.T108R	FOXP3_ENST00000518685.1_Missense_Mutation_p.T73R|FOXP3_ENST00000376199.2_Missense_Mutation_p.T73R|FOXP3_ENST00000455775.2_Missense_Mutation_p.T108R|FOXP3_ENST00000557224.1_Missense_Mutation_p.T73R|FOXP3_ENST00000376197.1_Missense_Mutation_p.T58R	NM_014009.3	NP_054728.2	Q9BZS1	FOXP3_HUMAN	forkhead box P3	108					B cell homeostasis|cerebellum development|chromatin remodeling|embryo development|myeloid cell homeostasis|negative regulation of activated T cell proliferation|negative regulation of chronic inflammatory response|negative regulation of CREB transcription factor activity|negative regulation of cytokine secretion|negative regulation of histone acetylation|negative regulation of histone deacetylation|negative regulation of interferon-gamma biosynthetic process|negative regulation of interferon-gamma production|negative regulation of interleukin-10 production|negative regulation of interleukin-2 biosynthetic process|negative regulation of interleukin-2 production|negative regulation of interleukin-4 production|negative regulation of interleukin-5 production|negative regulation of interleukin-6 production|negative regulation of isotype switching to IgE isotypes|negative regulation of NF-kappaB transcription factor activity|negative regulation of T cell cytokine production|negative regulation of tumor necrosis factor production|pattern specification process|positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation|positive regulation of histone acetylation|positive regulation of immature T cell proliferation in thymus|positive regulation of peripheral T cell tolerance induction|positive regulation of T cell anergy|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transforming growth factor-beta1 production|post-embryonic development|regulation of isotype switching to IgG isotypes|response to virus|T cell homeostasis|T cell receptor signaling pathway|tolerance induction to self antigen	cytoplasm|nucleus|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|histone acetyltransferase binding|histone deacetylase binding|NF-kappaB binding|NFAT protein binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription corepressor activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)	10	Ovarian(276;0.236)					GGCATCCACCGTTGAGAGCTG	0.677000													13	24					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57326157	57326157	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:57326157G>T	ENST00000326441.9	-	10	4016	c.3653C>A	c.(3652-3654)cCt>cAt	p.P1218H	ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.P1092H|PEG3_ENST00000423103.2_Missense_Mutation_p.P1218H|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.P1094H|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1218					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGCAAGAGCAGGATTCCTCTC	0.483000													11	50					9.31168e-06	1.05924e-05	1	1	0
BDP1	55814	broad.mit.edu	37	5	70785246	70785246	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr5:70785246G>T	ENST00000358731.4	+	10	1492	c.1229G>T	c.(1228-1230)tGt>tTt	p.C410F	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	410	Required for phosphorylation by CSNK2A1.				regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		AAAGTTGCCTGTGAAGGAGTG	0.358000													9	13					1.12685e-05	1.27453e-05	1	1	0
KRAS	3845	broad.mit.edu	37	12	25398282	25398282	+	Missense_Mutation	SNP	C	C	A	rs121913535		TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:25398282C>A	ENST00000311936.3	-	2	228	c.37G>T	c.(37-39)Ggc>Tgc	p.G13C	KRAS_ENST00000256078.4_Missense_Mutation_p.G13C|KRAS_ENST00000557334.1_Missense_Mutation_p.G13C|KRAS_ENST00000556131.1_Missense_Mutation_p.G13C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	13			G -> D (in a breast carcinoma cell line and GASC; somatic mutation).|G -> R (in pylocytic astrocytoma; somatic mutation; increase activation of the Ras pathway).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G13C(213)|p.G13S(59)|p.G13R(43)|p.G12_G13insG(3)|p.G13N(1)|p.G13I(1)|p.G12_G13insA(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TTGCCTACGCCACCAGCTCCA	0.343000	G13C(MORCPR_LUNG)|G13C(NCIH1355_LUNG)|G13C(NCIH1734_LUNG)|G13C(TOV21G_OVARY)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			14	10					1.5739e-10	2.08279e-10	1	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299578	125299578	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:125299578C>A	ENST00000538699.1	-	2	410	c.330G>T	c.(328-330)caG>caT	p.Q110H	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.Q110H	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	110										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						CGCACACCACCTGCCTGGCGT	0.652000													36	40					3.76114e-14	5.61342e-14	1	1	0
EGLN3	112399	broad.mit.edu	37	14	34419911	34419911	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr14:34419911C>A	ENST00000547327.2	-	1	376	c.48G>T	c.(46-48)ctG>ctT	p.L16L	EGLN3_ENST00000553215.1_Silent_p.L16L|EGLN3_ENST00000250457.3_Silent_p.L16L			Q9H6Z9	EGLN3_HUMAN	egl-9 family hypoxia-inducible factor 3	16					apoptosis	cytoplasm|nucleus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|upper_aerodigestive_tract(1)	15	Breast(36;0.0303)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.000246)|Lung(238;0.000959)|Epithelial(34;0.155)	GBM - Glioblastoma multiforme(112;0.0118)	Vitamin C(DB00126)	CGATGTACTCCAGGGCAATTT	0.627000													25	170					3.28513e-13	4.72535e-13	1	1	0
EN1	2019	broad.mit.edu	37	2	119603936	119603936	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:119603936G>C	ENST00000295206.6	-	1	1318	c.808C>G	c.(808-810)Ctc>Gtc	p.L270V		NM_001426.3	NP_001417.3	Q05925	HME1_HUMAN	engrailed homeobox 1	270					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	9						GGCCATACGAGAGGCTGCTGC	0.637000													4	28					0	0	1	0	0
KCTD14	65987	broad.mit.edu	37	11	77727789	77727789	+	Silent	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:77727789C>A	ENST00000353172.5	-	2	662	c.618G>T	c.(616-618)gcG>gcT	p.A206A	KCTD14_ENST00000533144.1_Silent_p.A176A	NM_001203260.1|NM_001203262.1|NM_023930.3	NP_001190189.1|NP_001190191.1|NP_076419.2	Q9BQ13	KCD14_HUMAN	potassium channel tetramerization domain containing 14	206						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.A206A(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	15	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1e-24)			TGTCTAGGACCGCCTTCCAGG	0.493000													55	31					7.47603e-22	1.22644e-21	1	1	0
GPC5	2262	broad.mit.edu	37	13	92797198	92797198	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr13:92797198G>T	ENST00000377067.3	+	7	1889	c.1517G>T	c.(1516-1518)gGa>gTa	p.G506V		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	506						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GGTTGCGGGGGATCAGGAAGT	0.433000													30	52					4.92203e-23	8.17592e-23	1	1	0
CNTN1	1272	broad.mit.edu	37	12	41323597	41323597	+	Splice_Site	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:41323597G>A	ENST00000551295.2	+	7	613		c.e7-1		CNTN1_ENST00000547849.1_Splice_Site|CNTN1_ENST00000347616.1_Splice_Site|CNTN1_ENST00000547702.1_Splice_Site|CNTN1_ENST00000348761.2_Splice_Site|CNTN1_ENST00000360099.3_Splice_Site	NM_001843.3	NP_001834.2	Q12860	CNTN1_HUMAN	contactin 1						axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(21)|lung(49)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	90	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TTTTCTCCTAGATGATCTTAG	0.343000													12	25					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													3	48					0	0	1	0	0
MELK	9833	broad.mit.edu	37	9	36657331	36657331	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:36657331A>T	ENST00000543751.1	+	12	1196	c.1051A>T	c.(1051-1053)Aca>Tca	p.T351S	MELK_ENST00000536860.1_Missense_Mutation_p.T335S|MELK_ENST00000298048.2_Missense_Mutation_p.T383S|MELK_ENST00000536987.1_Missense_Mutation_p.T252S|MELK_ENST00000545008.1_Missense_Mutation_p.T312S|MELK_ENST00000541717.1_Intron|MELK_ENST00000536329.1_Missense_Mutation_p.T312S|MELK_ENST00000538311.1_Missense_Mutation_p.T189S	NM_001256689.1	NP_001243618.1	Q14680	MELK_HUMAN	maternal embryonic leucine zipper kinase	383						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)	29		Acute lymphoblastic leukemia(2;1.09e-08)|all_hematologic(2;8.15e-06)	STAD - Stomach adenocarcinoma(86;0.228)			TGATTTATCAACAGGTGCTGC	0.363000													5	33					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88241831	88241831	+	Missense_Mutation	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:88241831A>T	ENST00000418177.2	-	10	3935	c.3568T>A	c.(3568-3570)Tgt>Agt	p.C1190S	GRM5_ENST00000393297.1_Missense_Mutation_p.C920S|GRM5_ENST00000305447.4_Missense_Mutation_p.C1190S|GRM5-AS1_ENST00000526448.1_RNA|GRM5_ENST00000455756.2_Missense_Mutation_p.C1158S|GRM5_ENST00000305432.5_Missense_Mutation_p.C1158S			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	1190					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GACGGGATACAGAGGGCCGAC	0.602000													24	26					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100831070	100831070	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:100831070C>T	ENST00000358544.2	+	47	8761	c.8650C>T	c.(8650-8652)Caa>Taa	p.Q2884*	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Nonsense_Mutation_p.Q2859*	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2884					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AAAACCACTGCAAAACATAGA	0.388000													11	28					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186277358	186277358	+	Missense_Mutation	SNP	C	C	G			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:186277358C>G	ENST00000445192.2	+	7	2552	c.2507C>G	c.(2506-2508)cCc>cGc	p.P836R	PRG4_ENST00000367486.3_Missense_Mutation_p.P793R|PRG4_ENST00000367483.4_Missense_Mutation_p.P795R|PRG4_ENST00000367485.4_Missense_Mutation_p.P743R|PRG4_ENST00000367484.3_Missense_Mutation_p.P365R	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	836	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						GAGCCTGCACCCACTACCCCC	0.577000													55	172					0	0	1	0	0
LRRC4	64101	broad.mit.edu	37	7	127670042	127670042	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr7:127670042C>A	ENST00000249363.3	-	2	909	c.652G>T	c.(652-654)Gtg>Ttg	p.V218L	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	218						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		TCCAGCCCCACCAGGGGGGTG	0.542000													9	37					1.12685e-05	1.27453e-05	1	1	0
ECE1	1889	broad.mit.edu	37	1	21582525	21582525	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:21582525G>A	ENST00000415912.2	-	8	1012	c.887C>T	c.(886-888)aCg>aTg	p.T296M	ECE1_ENST00000357071.4_Missense_Mutation_p.T300M|ECE1_ENST00000528294.1_5'UTR|ECE1_ENST00000374893.6_Missense_Mutation_p.T312M|ECE1_ENST00000264205.6_Missense_Mutation_p.T309M|ECE1_ENST00000436918.2_Missense_Mutation_p.T312M	NM_001113348.1	NP_001106819.1	P42892	ECE1_HUMAN	endothelin converting enzyme 1	312					bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	25		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		GGCCAGTGCCGTCTCAAAGTC	0.607000													11	45					0	0	1	0	0
PACRGL	133015	broad.mit.edu	37	4	20709441	20709441	+	Silent	SNP	C	C	A	rs74492021	by1000genomes	TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr4:20709441C>A	ENST00000360916.5	+	4	614	c.223C>A	c.(223-225)Cga>Aga	p.R75R	PACRGL_ENST00000538990.1_Intron|PACRGL_ENST00000444671.2_Intron|PACRGL_ENST00000503585.1_Silent_p.R75R|PACRGL_ENST00000507634.1_Silent_p.R75R|PACRGL_ENST00000502938.1_Intron|PACRGL_ENST00000295290.8_Silent_p.R75R|PACRGL_ENST00000513459.1_Intron|PACRGL_ENST00000502374.1_Intron	NM_145048.3	NP_659485.1	Q8N7B6	PACRL_HUMAN	PARK2 co-regulated-like	75							binding			endometrium(2)|lung(7)|prostate(1)	10						TGAACAGTCACGAGTGCCTTC	0.348000													8	32					2.17888e-05	2.42982e-05	1	1	0
COL5A1	1289	broad.mit.edu	37	9	137593141	137593141	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:137593141G>A	ENST00000371817.3	+	4	1030	c.616G>A	c.(616-618)Gtg>Atg	p.V206M	COL5A1_ENST00000464187.1_3'UTR	NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	206	Laminin G-like.|TSP N-terminal.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGGCATCATCGTGTTTGGCAC	0.552000													4	22					0	0	1	0	0
HDAC2	3066	broad.mit.edu	37	6	114281109	114281109	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:114281109C>A	ENST00000519065.1	-	2	502	c.126G>T	c.(124-126)ttG>ttT	p.L42F	HDAC2_ENST00000519108.1_Missense_Mutation_p.L12F|HDAC2_ENST00000398283.2_Missense_Mutation_p.L136F|HDAC2_ENST00000368632.2_Missense_Mutation_p.L12F			Q92769	HDAC2_HUMAN	histone deacetylase 2	42	Histone deacetylase.				blood coagulation|dendrite development|embryonic digit morphogenesis|epidermal cell differentiation|eyelid development in camera-type eye|fungiform papilla formation|hair follicle placode formation|maintenance of chromatin silencing|negative regulation of apoptosis|negative regulation of cell cycle|negative regulation of neuron projection development|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|odontogenesis of dentine-containing tooth|positive regulation of cell proliferation|positive regulation of proteolysis|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|ESC/E(Z) complex|NuRD complex|Sin3 complex	chromatin binding|enzyme binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|sequence-specific DNA binding|transcription factor binding			biliary_tract(1)|central_nervous_system(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(87;0.000629)|all_epithelial(87;0.00274)|Colorectal(196;0.0317)|all_lung(197;0.24)		all cancers(137;0.00318)|OV - Ovarian serous cystadenocarcinoma(136;0.00569)|Epithelial(106;0.0112)|GBM - Glioblastoma multiforme(226;0.0832)	Vorinostat(DB02546)	AATTTAACAGCAAGTTATGGG	0.308000													15	47					2.08468e-23	3.49205e-23	1	1	0
MICB	4277	broad.mit.edu	37	6	31475190	31475190	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:31475190G>A	ENST00000252229.6	+	5	985	c.906G>A	c.(904-906)gtG>gtA	p.V302V	MICB_ENST00000399150.3_Silent_p.V259V|MICB_ENST00000538442.1_Silent_p.V270V	NM_005931.3	NP_005922.2	Q29980	MICB_HUMAN	MHC class I polypeptide-related sequence B	302					antigen processing and presentation|cytolysis|gamma-delta T cell activation|immune response|immune response-activating cell surface receptor signaling pathway|interspecies interaction between organisms|negative regulation of defense response to virus by host|response to heat|response to oxidative stress|response to retinoic acid	integral to plasma membrane|MHC class I protein complex	natural killer cell lectin-like receptor binding			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)	13						AGGCGCTGGTGCTTCAGAGTC	0.473000													21	11					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648739	130648739	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:130648739G>T	ENST00000539839.1	+	1	1736	c.1154G>T	c.(1153-1155)cGt>cTt	p.R385L	FZD10_ENST00000229030.4_Missense_Mutation_p.V418L	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		CTCGGGCTTCGTGGCCCTGTT	0.612000													18	59					7.45023e-12	1.02699e-11	1	1	0
MYF5	4617	broad.mit.edu	37	12	81112732	81112732	+	Missense_Mutation	SNP	C	C	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:81112732C>A	ENST00000228644.3	+	3	822	c.670C>A	c.(670-672)Ctc>Atc	p.L224I		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	224					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						TGGGTTGCCTCTCCAGGATCT	0.493000													32	38					1.62565e-12	2.27247e-12	1	1	0
DHX30	22907	broad.mit.edu	37	3	47882389	47882389	+	Missense_Mutation	SNP	G	G	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr3:47882389G>C	ENST00000446256.2	+	8	844	c.272G>C	c.(271-273)cGg>cCg	p.R91P	DHX30_ENST00000457607.1_Missense_Mutation_p.R158P|DHX30_ENST00000445061.1_Missense_Mutation_p.R130P|DHX30_ENST00000348968.4_Missense_Mutation_p.R102P	NM_014966.3	NP_055781.2	Q7L2E3	DHX30_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 30	130	DRBM.					mitochondrial nucleoid	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(13)|ovary(4)|pancreas(1)|prostate(1)|skin(3)	37				BRCA - Breast invasive adenocarcinoma(193;0.000696)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		CTAGGTCCCCGGAATGAGTTG	0.577000													24	16					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55606955	55606955	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:55606955G>A	ENST00000378396.1	+	1	728	c.728G>A	c.(727-729)tGt>tAt	p.C243Y		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				TTCTCCACCTGTGCCTCCCAC	0.502000													18	47					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976934	119976934	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:119976934G>T	ENST00000313400.4	-	3	818	c.718C>A	c.(718-720)Ccc>Acc	p.P240T	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000361209.2_Missense_Mutation_p.P240T|ASTN2_ENST00000373996.3_Missense_Mutation_p.P240T			O75129	ASTN2_HUMAN	astrotactin 2	240						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CTCTTCTGGGGGATGCGGCGA	0.642000													9	25					3.07112e-06	3.54428e-06	1	1	0
TRIM44	54765	broad.mit.edu	37	11	35706848	35706848	+	Missense_Mutation	SNP	G	G	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:35706848G>T	ENST00000299413.5	+	2	1018	c.711G>T	c.(709-711)ttG>ttT	p.L237F		NM_017583.4	NP_060053.2	Q96DX7	TRI44_HUMAN	tripartite motif containing 44	237						intracellular	protein binding|zinc ion binding			endometrium(1)|large_intestine(8)|lung(4)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	18	all_lung(20;0.0317)|Lung NSC(22;0.0661)|all_epithelial(35;0.115)	all_hematologic(20;0.107)				TGATCGAATTGGTGGAAAGGT	0.428000													25	21					5.60225e-13	7.94319e-13	1	1	0
OR5T1	390155	broad.mit.edu	37	11	56044039	56044039	+	Missense_Mutation	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr11:56044039G>A	ENST00000313033.2	+	1	1011	c.925G>A	c.(925-927)Gta>Ata	p.V309I		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					GAACAAAGATGTAAAGGAGGC	0.348000													25	40					0	0	1	0	0
TMEM8A	58986	broad.mit.edu	37	16	427672	427672	+	Translation_Start_Site	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:427672C>T	ENST00000250930.3	-	0	204				TMEM8A_ENST00000431232.2_Splice_Site_p.V100_splice|TMEM8A_ENST00000476735.1_5'UTR			Q9HCN3	TMM8A_HUMAN	transmembrane protein 8A						cell adhesion	integral to plasma membrane				central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	14						GCCACCTACACGGTGATCTCC	0.706000													3	7					0	0	1	0	0
CNKSR2	22866	broad.mit.edu	37	X	21545028	21545028	+	Missense_Mutation	SNP	C	C	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chrX:21545028C>T	ENST00000425654.2	+	10	1481	c.1001C>T	c.(1000-1002)tCc>tTc	p.S334F	CNKSR2_ENST00000279451.4_Missense_Mutation_p.S334F|CNKSR2_ENST00000543067.1_Missense_Mutation_p.S285F|CNKSR2_ENST00000379510.3_Missense_Mutation_p.S334F	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	334	DUF1170.				regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						GCCACGCCTTCCAGCACCATC	0.453000													133	135					0	0	1	0	0
RAP1B	5908	broad.mit.edu	37	12	69044230	69044230	+	Silent	SNP	A	A	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr12:69044230A>T	ENST00000250559.9	+	3	339	c.108A>T	c.(106-108)atA>atT	p.I36I	RAP1B_ENST00000450214.2_Intron|RAP1B_ENST00000463493.1_Intron|RAP1B_ENST00000543697.1_Silent_p.I36I|RAP1B_ENST00000542145.1_Silent_p.I36I|RAP1B_ENST00000341355.5_Silent_p.I36I|RAP1B_ENST00000541216.1_Silent_p.I36I|RAP1B_ENST00000540209.1_Silent_p.I36I|RAP1B_ENST00000539091.1_Intron|RAP1B_ENST00000537460.1_Silent_p.I36I|RAP1B_ENST00000543393.1_Intron|RAP1B_ENST00000378985.3_Intron|RAP1B_ENST00000393436.5_Silent_p.I36I	NM_001010942.2|NM_001251921.1|NM_001251922.1|NM_015646.5	NP_001010942.1|NP_001238850.1|NP_001238851.1|NP_056461.1	P61224	RAP1B_HUMAN	RAP1B, member of RAS oncogene family	36					blood coagulation|energy reserve metabolic process|regulation of establishment of cell polarity|regulation of insulin secretion	cell-cell junction|cytosol	GDP binding|GTP binding|GTPase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(2)|urinary_tract(2)	12	Breast(13;1.24e-05)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)	GBM - Glioblastoma multiforme(7;0.000306)		ATCCTACGATAGAAGATTCTT	0.234000													5	18					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5294804	5294804	+	Missense_Mutation	SNP	T	T	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr20:5294804T>C	ENST00000546004.1	-	2	458	c.212A>G	c.(211-213)aAc>aGc	p.N71S	PROKR2_ENST00000217270.3_Missense_Mutation_p.N71S			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	71						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						AAAGACAAAGTTACCGATGCC	0.547000										HNSCC(71;0.22)			10	50					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90022631	90022631	+	Silent	SNP	G	G	A			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr15:90022631G>A	ENST00000268122.4	-	5	827	c.759C>T	c.(757-759)acC>acT	p.T253T	RHCG_ENST00000544600.1_Silent_p.T253T	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein	253					amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding	p.T253T(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					AGGAGCAGTAGGTGTTGATGG	0.597000													35	18					0	0	1	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67242954	67242955	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr1:67242954_67242955delGG	ENST00000282670.2	+	5	485_486	c.357_358delGG	c.(355-360)aaacfs	p.KD119fs		NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	119										large_intestine(2)|lung(10)|skin(1)	13						CCCAGGTCAAGGACTTGATGAT	0.371													10	44	---	---	---	---					
LINC01250	101927554	broad.mit.edu	37	2	2910813	2910814	+	RNA	INS	-	-	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:2910813_2910814insT	ENST00000457478.1	-	0	594																											tccaccccctctccccagccca	0.708													5	2	---	---	---	---					
AFF3	3899	broad.mit.edu	37	2	100218011	100218013	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:100218011_100218013delGCT	ENST00000317233.4	-	13	1490_1492	c.1255_1257delAGC	c.(1255-1257)del	p.S419del	AFF3_ENST00000409579.1_In_Frame_Del_p.S444del|AFF3_ENST00000409236.1_In_Frame_Del_p.S419del|AFF3_ENST00000356421.2_In_Frame_Del_p.S444del	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	419	Poly-Ser.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						tgctgctgccgctgctgctgctg	0.685													2	4	---	---	---	---					
LRP1B	53353	broad.mit.edu	37	2	141665475	141665475	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr2:141665475delG	ENST00000389484.3	-	22	4462	c.3491delC	c.(3490-3492)ctfs	p.P1164fs		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1164	LDL-receptor class A 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGAGCCATCAGGACAATCCTT	0.433										TSP Lung(27;0.18)			49	118	---	---	---	---					
IMPG1	3617	broad.mit.edu	37	6	76734925	76734926	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr6:76734925_76734926insT	ENST00000369963.3	-	4	502_503	c.313_314insA	c.(313-315)tgtfs	p.C105fs	IMPG1_ENST00000369950.3_Frame_Shift_Ins_p.C183fs			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	183					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TGAAATGACAATGGTTTCACCA	0.327													16	65	---	---	---	---					
ZFHX4	79776	broad.mit.edu	37	8	77764624	77764626	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr8:77764624_77764626delCAG	ENST00000521891.2	+	10	5915_5917	c.5467_5469delCAG	c.(5467-5469)del	p.Q1829del	ZFHX4_ENST00000455469.2_In_Frame_Del_p.Q1784del|ZFHX4_ENST00000518282.1_In_Frame_Del_p.Q1803del|ZFHX4_ENST00000050961.6_In_Frame_Del_p.Q1784del	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1784						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			accacctccacagcagcagcagc	0.473										HNSCC(33;0.089)			2	4	---	---	---	---					
PTPLAD2	401494	broad.mit.edu	37	9	21007045	21007046	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr9:21007045_21007046insT	ENST00000495827.1	-	7	734_735	c.689_690insA	c.(688-690)aaafs	p.K230fs	PTPLAD2_ENST00000513293.2_Frame_Shift_Ins_p.K230fs	NM_001010915.3	NP_001010915.2	Q5VWC8	HACD4_HUMAN	protein tyrosine phosphatase-like A domain containing 2	230	Poly-Lys.				fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	lyase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)	10				Lung(24;6.02e-14)|LUSC - Lung squamous cell carcinoma(38;1.29e-10)		TTCACATCTTCTTTTTTTTAAT	0.371													7	69	---	---	---	---					
COQ7	10229	broad.mit.edu	37	16	19079000	19079001	+	In_Frame_Ins	INS	-	-	GGC			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:19079000_19079001insGGC	ENST00000321998.5	+	1	80_81	c.14_15insGGC	c.(13-15)ggc>gGGCgc	p.5_6insR	RP11-626G11.5_ENST00000567047.1_RNA|COQ7_ENST00000568985.1_In_Frame_Ins_p.5_6insR	NM_016138.4	NP_057222.2	Q99807	COQ7_HUMAN	coenzyme Q7 homolog, ubiquinone (yeast)	5	Poly-Ala.				ubiquinone biosynthetic process	mitochondrial inner membrane|nucleus	oxidoreductase activity|transition metal ion binding			breast(1)|large_intestine(1)|lung(3)|prostate(1)|skin(3)|urinary_tract(1)	10						AGTTgcgccggggcggcggcgg	0.649													4	6	---	---	---	---					
FBXL19	54620	broad.mit.edu	37	16	30939203	30939204	+	Frame_Shift_Ins	INS	-	-	C			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr16:30939203_30939204insC	ENST00000338343.4	+	5	933_934	c.546_547insC	c.(544-549)ggccccfs	p.GP182fs	FBXL19_ENST00000471231.2_5'UTR|FBXL19_ENST00000380310.2_Frame_Shift_Ins_p.GP202fs|FBXL19_ENST00000565690.1_Intron|FBXL19_ENST00000562319.1_Frame_Shift_Ins_p.GP182fs			Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	202							DNA binding|zinc ion binding			breast(2)|endometrium(3)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						TGCCTGCCGGGCCCCCCCCGGA	0.708													2	4	---	---	---	---					
CENPV	201161	broad.mit.edu	37	17	16256469	16256471	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:16256469_16256471delCGG	ENST00000299736.4	-	1	342_344	c.280_282delCCG	c.(280-282)del	p.P94del	CENPV_ENST00000476243.1_5'UTR	NM_181716.2	NP_859067.2	Q7Z7K6	CENPV_HUMAN	centromere protein V	97	Pro-rich.				cell division|centromeric heterochromatin formation|mitosis|positive regulation of cytokinesis|regulation of chromosome organization	condensed chromosome kinetochore|cytoplasm|nucleus|spindle midzone	carbon-sulfur lyase activity			endometrium(1)|large_intestine(2)	3						TCGCGGGAGTcggcggcggcggc	0.773													2	4	---	---	---	---					
HOXB4	3214	broad.mit.edu	37	17	46657167	46657168	+	Translation_Start_Site	INS	-	-	AT			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:46657167_46657168insAT	ENST00000332503.5	-	0	305_306				HOXB3_ENST00000552000.2_Intron|HOXB3_ENST00000489475.1_Intron|HOXB3_ENST00000476342.1_Intron|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Intron|HOXB3_ENST00000472863.1_Intron|HOXB3_ENST00000498678.1_Intron	NM_024015.4	NP_076920.1	P17483	HXB4_HUMAN	homeobox B4							nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	9						ACTACATATACATATATATATA	0.361													6	5	---	---	---	---					
KIF19	124602	broad.mit.edu	37	17	72350399	72350400	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr17:72350399_72350400delCC	ENST00000389916.4	+	18	2545_2546	c.2407_2408delCC	c.(2407-2409)cfs	p.P803fs		NM_153209.3	NP_694941.2	Q2TAC6	KIF19_HUMAN	kinesin family member 19	803					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	41						CCTGCTGGCACCCGCGACAGAG	0.713													22	10	---	---	---	---					
APCDD1	147495	broad.mit.edu	37	18	10471699	10471699	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr18:10471699delG	ENST00000355285.4	+	3	769	c.415delG	c.(415-417)ggfs	p.G140fs	APCDD1_ENST00000578882.1_Frame_Shift_Del_p.G140fs	NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	140					hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		GATCATCCGAGGGGGCACGGA	0.597													8	33	---	---	---	---					
GDF1	2657	broad.mit.edu	37	19	18981067	18981069	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-55-7910-01A-11D-2167-08	TCGA-55-7910-11A-01D-2167-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73020d02-b5f8-4906-a2ae-fb870b62e6ca	d10a25f9-5c37-4092-ad5a-b21414f9b568	g.chr19:18981067_18981069delAGG	ENST00000247005.6	-	7	1393_1395	c.48_50delCCT	c.(46-51)ctg>ct	p.LL16del	CERS1_ENST00000427170.2_3'UTR					growth differentiation factor 1																		CAGCAGGGCCAGGAGGAGGAGGA	0.749													2	4	---	---	---	---					
