Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF208	7757	broad.mit.edu	37	19	22154249	22154249	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr19:22154249A>G	ENST00000397126.4	-	4	3735	c.3587T>C	c.(3586-3588)cTc>cCc	p.L1196P	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATTTGTAGAGTTTCTCTCC	0.378000													3	54					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62316891	62316891	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr20:62316891G>A	ENST00000318100.4	+	15	2034	c.1207G>A	c.(1207-1209)Gac>Aac	p.D403N	RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.D403N|RTEL1_ENST00000508582.2_Missense_Mutation_p.D427N|RTEL1_ENST00000360203.5_Missense_Mutation_p.D403N|RTEL1_ENST00000370018.3_Missense_Mutation_p.D403N			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	403					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GTTCAGTGTGGACCCCTCCGA	0.627000													12	46					0	0	1	0	0
ACTR5	79913	broad.mit.edu	37	20	37394972	37394972	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr20:37394972G>A	ENST00000243903.4	+	7	1422	c.1385G>A	c.(1384-1386)gGa>gAa	p.G462E		NM_024855.3	NP_079131.3	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog (yeast)	462					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding			kidney(2)|large_intestine(2)|liver(1)|lung(5)|skin(2)	12		Myeloproliferative disorder(115;0.00878)				TCTCTCATAGGAGAAGAACAG	0.433000													54	109					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51693912	51693912	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr15:51693912C>T	ENST00000335449.6	+	9	1206	c.1150C>T	c.(1150-1152)Cac>Tac	p.H384Y	GLDN_ENST00000396399.2_Missense_Mutation_p.H260Y	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	384	Olfactomedin-like.				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		TCTCTACTACCACAAAGGGGG	0.498000											OREG0023125	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	41					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													6	73					0	0	1	0	0
MEOX2	4223	broad.mit.edu	37	7	15666509	15666509	+	Silent	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr7:15666509G>A	ENST00000262041.5	-	2	961	c.552C>T	c.(550-552)aaC>aaT	p.N184N		NM_005924.4	NP_005915.2	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	184					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TGGGTTTGCTGTTGACTTCTG	0.378000													41	81					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41767837	41767837	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr13:41767837T>C	ENST00000379483.3	-	1	865	c.557A>G	c.(556-558)cAc>cGc	p.H186R		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	186							protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		TCGAAGCTTGTGATGGTCGAA	0.542000													10	81					0	0	1	0	0
SCYL1	57410	broad.mit.edu	37	11	65304101	65304101	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr11:65304101G>A	ENST00000524944.1	+	13	1729	c.1696G>A	c.(1696-1698)Gca>Aca	p.A566T	SCYL1_ENST00000279270.6_Missense_Mutation_p.A566T|SCYL1_ENST00000527630.1_Missense_Mutation_p.A566T|SCYL1_ENST00000527009.1_Missense_Mutation_p.A423T|SCYL1_ENST00000525364.1_Missense_Mutation_p.A566T|SCYL1_ENST00000270176.5_Missense_Mutation_p.A566T|SCYL1_ENST00000533862.1_Missense_Mutation_p.A566T|SCYL1_ENST00000420247.2_Missense_Mutation_p.A566T			Q96KG9	NTKL_HUMAN	SCY1-like 1 (S. cerevisiae)	566					regulation of transcription, DNA-dependent|retrograde vesicle-mediated transport, Golgi to ER|transcription, DNA-dependent	cis-Golgi network|COPI vesicle coat|ER-Golgi intermediate compartment|microtubule organizing center|nucleus	ATP binding|DNA binding|protein tyrosine kinase activity			ovary(1)|skin(1)	2						GGGAGGAGCCGCAGCTAGCTG	0.627000													4	98					0	0	1	0	0
TNFRSF10A	8797	broad.mit.edu	37	8	23049393	23049393	+	Silent	SNP	G	G	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr8:23049393G>T	ENST00000221132.3	-	10	1285	c.1221C>A	c.(1219-1221)gcC>gcA	p.A407A		NM_003844.3	NP_003835.3	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily, member 10a	407	Death.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			NS(2)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|skin(1)	16		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TTGCATACAAGGCATCCCCTG	0.542000													4	175					0.217242	0.220534	1	1	0
KEL	3792	broad.mit.edu	37	7	142658923	142658923	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr7:142658923G>A	ENST00000355265.2	-	2	514	c.40C>T	c.(40-42)Cgc>Tgc	p.R14C	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	14					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GCCTGGCTGCGTTCCCTCGGC	0.542000													29	464					0	0	1	0	0
KLK10	5655	broad.mit.edu	37	19	51520452	51520452	+	Silent	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr19:51520452G>A	ENST00000309958.3	-	3	401	c.183C>T	c.(181-183)gtC>gtT	p.V61V	KLK10_ENST00000358789.3_Silent_p.V61V|KLK10_ENST00000391805.1_Silent_p.V61V	NM_002776.4	NP_002767.2	O43240	KLK10_HUMAN	kallikrein-related peptidase 10	61	Peptidase S1.				cell cycle|proteolysis	extracellular region	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	13		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00328)|GBM - Glioblastoma multiforme(134;0.00885)		TGAAGAGCGAGACCTGCCAGG	0.682000											OREG0025646	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	7					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140176801	140176801	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr5:140176801C>T	ENST00000526136.1	+	1	2252	c.2252C>T	c.(2251-2253)tCg>tTg	p.S751L	PCDHA2_ENST00000520672.2_Missense_Mutation_p.S751L|PCDHA2_ENST00000378132.1_Missense_Mutation_p.S751L|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCTTACTCGCAGCAGAGG	0.667000													8	91					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32430029	32430029	+	Splice_Site	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chrX:32430029G>A	ENST00000357033.4	-	30	4279	c.4071_splice	c.e30-1	p.A1358_splice	DMD_ENST00000378677.2_Splice_Site_p.A1354_splice	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1358					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCTCCTTACAGCCTAAAAAGA	0.393000													14	25					0	0	1	0	0
YTHDC1	91746	broad.mit.edu	37	4	69202911	69202911	+	Silent	SNP	T	T	C			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr4:69202911T>C	ENST00000344157.4	-	4	1052	c.717A>G	c.(715-717)gaA>gaG	p.E239E	YTHDC1_ENST00000355665.3_Silent_p.E239E|YTHDC1_ENST00000579690.1_Silent_p.E239E	NM_001031732.2	NP_001026902.1	Q96MU7	YTDC1_HUMAN	YTH domain containing 1	239	Glu-rich.									NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	30						cctcctcctcttcctcctcct	0.473000													4	44					0	0	1	0	0
RCN3	57333	broad.mit.edu	37	19	50045899	50045899	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr19:50045899A>T	ENST00000270645.3	+	6	1216	c.769A>T	c.(769-771)Aag>Tag	p.K257*		NM_020650.2	NP_065701.2	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	257	EF-hand 5.					endoplasmic reticulum lumen	calcium ion binding|protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		GGATCTGAACAAGGATGGGCA	0.682000													3	31					0	0	1	0	0
DIO2	1734	broad.mit.edu	37	14	80669369	80669369	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr14:80669369T>C	ENST00000557010.1	-	4	870	c.485A>G	c.(484-486)gAt>gGt	p.D162G	DIO2_ENST00000557125.1_Missense_Mutation_p.M37V|DIO2_ENST00000555750.1_Missense_Mutation_p.D198G|DIO2_ENST00000438257.4_Missense_Mutation_p.D162G|DIO2_ENST00000422005.3_3'UTR	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	162					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		ATGAGCCTCATCAATGTAGAC	0.557000											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	70					0	0	1	0	0
NFIA	4774	broad.mit.edu	37	1	61824896	61824896	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr1:61824896G>A	ENST00000403491.3	+	6	1380	c.896G>A	c.(895-897)cGc>cAc	p.R299H	NFIA_ENST00000371184.2_Intron|NFIA_ENST00000371189.4_Missense_Mutation_p.R344H|NFIA_ENST00000371187.3_Missense_Mutation_p.R299H|NFIA_ENST00000371191.1_Missense_Mutation_p.R322H|NFIA_ENST00000371185.2_Missense_Mutation_p.R277H|NFIA_ENST00000407417.3_Missense_Mutation_p.R291H|NFIA_ENST00000485903.2_Missense_Mutation_p.R299H|NFIA_ENST00000479364.1_3'UTR	NM_001134673.3|NM_005595.4	NP_001128145.1|NP_005586.1	Q12857	NFIA_HUMAN	nuclear factor I/A	299					DNA replication|viral genome replication	cell junction|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding		NFIA/EHF(2)	endometrium(1)|kidney(2)|large_intestine(8)|lung(20)|pancreas(1)|prostate(1)|skin(1)	34						GGCCAAGGGCGCTCCCCAGGA	0.527000													30	145					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216465672	216465672	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr1:216465672C>T	ENST00000366943.2	-	10	2071	c.1685G>A	c.(1684-1686)cGc>cAc	p.R562H	USH2A_ENST00000307340.3_Missense_Mutation_p.R562H|USH2A_ENST00000366942.3_Missense_Mutation_p.R562H			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	562	Laminin EGF-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATCACCTTGGCGGAAAGGCTT	0.363000										HNSCC(13;0.011)			8	88					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1270391	1270391	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr16:1270391G>T	ENST00000348261.5	+	35	6707	c.6459G>T	c.(6457-6459)caG>caT	p.Q2153H	CACNA1H_ENST00000565831.1_Missense_Mutation_p.Q2147H|CACNA1H_ENST00000358590.4_Missense_Mutation_p.Q2147H	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	2153					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	CAGACGAGCAGTGGCGGCCCT	0.731000													4	11					0.00909568	0.00952204	1	1	0
STK38	11329	broad.mit.edu	37	6	36467711	36467711	+	Silent	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr6:36467711G>A	ENST00000229812.7	-	10	1176	c.891C>T	c.(889-891)acC>acT	p.T297T		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	297	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGTTGTACCCGGTCTGCATGA	0.527000													4	188					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47746006	47746006	+	Silent	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr1:47746006C>T	ENST00000360380.3	-	13	2487	c.2124G>A	c.(2122-2124)aaG>aaA	p.K708K	STIL_ENST00000371877.3_Silent_p.K708K|STIL_ENST00000396221.2_Silent_p.K708K|STIL_ENST00000337817.5_Silent_p.K708K|STIL_ENST00000243182.6_Silent_p.K708K			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	708	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				CTGACTCAGTCTTGGGTGTGT	0.488000													6	194					0	0	1	0	0
ANKRD20A5P	440482	broad.mit.edu	37	18	14183721	14183721	+	RNA	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr18:14183721C>T	ENST00000581935.1	+	0	572																				lung(3)	3						CAGAAAATGCCAGATTGATAT	0.388000													4	145					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151155294	151155294	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr3:151155294C>T	ENST00000282466.3	-	6	7054	c.7055G>A	c.(7054-7056)gGa>gAa	p.G2352E	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2352	Ig-like C2-type 10.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGTGGACTTTCCCAGCTGGGC	0.418000													57	109					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172501872	172501872	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr1:172501872G>T	ENST00000367723.3	+	1	384	c.260G>T	c.(259-261)cGa>cTa	p.R87L		NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		AGAGAAAAACGAATTCTGGAA	0.517000													10	53					1.08611e-07	1.23338e-07	1	1	0
TTYH1	57348	broad.mit.edu	37	19	54930464	54930464	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr19:54930464G>A	ENST00000301194.4	+	2	411	c.289G>A	c.(289-291)Gcc>Acc	p.A97T	TTYH1_ENST00000376530.3_Missense_Mutation_p.A97T|TTYH1_ENST00000376531.3_Missense_Mutation_p.A97T|TTYH1_ENST00000391739.3_Missense_Mutation_p.A146T			Q9H313	TTYH1_HUMAN	tweety family member 1	97					cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		CTGCATTGTCGCCCTTCTCGC	0.706000													8	17					0	0	1	0	0
ADAM23	8745	broad.mit.edu	37	2	207426992	207426992	+	Silent	SNP	A	A	G			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr2:207426992A>G	ENST00000264377.3	+	13	1648	c.1320A>G	c.(1318-1320)caA>caG	p.Q440Q	ADAM23_ENST00000374416.1_Silent_p.Q440Q|ADAM23_ENST00000374415.3_Silent_p.Q440Q	NM_003812.2	NP_003803.1	O75077	ADA23_HUMAN	ADAM metallopeptidase domain 23	440	Peptidase M12B.				cell adhesion|central nervous system development|proteolysis	extracellular region|integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			NS(2)|breast(1)|endometrium(6)|kidney(3)|large_intestine(5)|liver(2)|lung(22)|ovary(2)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	51				LUSC - Lung squamous cell carcinoma(261;0.0961)|Lung(261;0.182)|Epithelial(149;0.205)		TTGGAATCCAATGGGAACCTT	0.413000													7	287					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108477232	108477232	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr2:108477232T>C	ENST00000408999.3	+	13	1846	c.1769T>C	c.(1768-1770)cTt>cCt	p.L590P	RGPD4_ENST00000354986.4_Missense_Mutation_p.L590P	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	590					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						GGCAGTGGTCTTAATTCTTTT	0.308000													84	105					0	0	1	0	0
OR8B8	26493	broad.mit.edu	37	11	124310402	124310402	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr11:124310402C>T	ENST00000328064.2	-	1	652	c.580G>A	c.(580-582)Gtg>Atg	p.V194M		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGCTCATTCACATAGGTGCTG	0.473000													7	87					0	0	1	0	0
SPG20	23111	broad.mit.edu	37	13	36909703	36909703	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr13:36909703G>A	ENST00000451493.1	-	2	482	c.265C>T	c.(265-267)Cgc>Tgc	p.R89C	SPG20_ENST00000495510.1_5'UTR|SPG20_ENST00000355182.4_Missense_Mutation_p.R89C|SPG20_ENST00000438666.2_Missense_Mutation_p.R89C|SPG20_ENST00000494062.2_Missense_Mutation_p.R89C	NM_001142295.1	NP_001135767.1	Q8N0X7	SPG20_HUMAN	spastic paraplegia 20 (Troyer syndrome)	89	MIT.				cell death	cytoplasm	ubiquitin protein ligase binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	27		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;2.42e-08)|Epithelial(112;1.58e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00128)|BRCA - Breast invasive adenocarcinoma(63;0.0125)|GBM - Glioblastoma multiforme(144;0.026)		AGCCTGGTGCGTACATTCTGT	0.443000													3	65					0	0	1	0	0
PTDSS1	9791	broad.mit.edu	37	8	97312064	97312064	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr8:97312064C>T	ENST00000517309.1	+	6	1069	c.743C>T	c.(742-744)gCa>gTa	p.A248V	PTDSS1_ENST00000455950.2_Missense_Mutation_p.A102V|PTDSS1_ENST00000522072.1_Missense_Mutation_p.A45V|PTDSS1_ENST00000518776.1_3'UTR	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	248					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TACCACTGGGCAAGCTTCAAG	0.408000													33	60					0	0	1	0	0
TSPAN10	83882	broad.mit.edu	37	17	79609410	79609410	+	RNA	SNP	G	G	T	rs7406219	by1000genomes	TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr17:79609410G>T	ENST00000328585.4	+	0	62					NM_031945.3	NP_114151.3	Q9H1Z9	TSN10_HUMAN	tetraspanin 10							integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CGGCGCCTGTGCTGGGGGCTT	0.657000													4	98					1.23904e-05	1.36091e-05	1	1	0
LOC101927060	101927060	broad.mit.edu	37	17	45128671	45128671	+	RNA	SNP	T	T	G	rs1056072	by1000genomes	TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr17:45128671T>G	ENST00000575173.1	-	0	418																											GCTCACAAAATAAGTTCCAGG	0.323000													3	126					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587657	43587657	+	RNA	SNP	C	C	T	rs148404065	by1000genomes	TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr17:43587657C>T	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GGTGACAACACATCTGTTTTA	0.323000													5	148					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142237983	142237983	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr2:142237983C>T	ENST00000389484.3	-	3	1296	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	109	LDL-receptor class A 2.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGTACTCCTTCGTCATACCCA	0.413000										TSP Lung(27;0.18)			7	77					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6485624	6485624	+	Silent	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr7:6485624G>A	ENST00000297056.6	-	2	376	c.207C>T	c.(205-207)gtC>gtT	p.V69V	DAGLB_ENST00000421761.2_5'UTR|DAGLB_ENST00000425398.2_Silent_p.V69V|KDELR2_ENST00000463747.1_5'UTR|DAGLB_ENST00000436575.1_Silent_p.V28V|DAGLB_ENST00000479922.2_5'UTR|DAGLB_ENST00000428902.2_5'UTR	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta	69					lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CAGTACATATGACAACTGCCA	0.408000													68	94					0	0	1	0	0
C11orf68	83638	broad.mit.edu	37	11	65685011	65685011	+	Silent	SNP	G	G	C			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr11:65685011G>C	ENST00000438576.2	-	2	886	c.801C>G	c.(799-801)ctC>ctG	p.L267L	C11orf68_ENST00000530188.1_Silent_p.L225L|C11orf68_ENST00000449692.3_Silent_p.L266L			Q9H3H3	CK068_HUMAN	chromosome 11 open reading frame 68	225										large_intestine(1)|lung(3)	4				READ - Rectum adenocarcinoma(159;0.166)		GGCTCTCATAGAGAGTGGGGC	0.602000													40	43					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	82					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45128685	45128685	+	RNA	SNP	T	T	C	rs145089594	by1000genomes	TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr17:45128685T>C	ENST00000575173.1	-	0	418																											TTCCAGGATATGGCTATACTG	0.303000													4	147					0	0	1	0	0
MYT1	4661	broad.mit.edu	37	20	62858781	62858781	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr20:62858781G>C	ENST00000536311.1	+	17	2987	c.2623G>C	c.(2623-2625)Ggc>Cgc	p.G875R	MYT1_ENST00000328439.1_Missense_Mutation_p.G848R|MYT1_ENST00000360149.4_Missense_Mutation_p.G527R			Q01538	MYT1_HUMAN	myelin transcription factor 1	848					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					CCCCACGCCCGGCTGTGACGG	0.677000													3	84					0	0	1	0	0
ANKRD17	26057	broad.mit.edu	37	4	73956679	73956679	+	Silent	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr4:73956679C>T	ENST00000358602.4	-	29	6782	c.6666G>A	c.(6664-6666)tcG>tcA	p.S2222S	ANKRD17_ENST00000330838.6_Silent_p.S1971S|ANKRD17_ENST00000509867.2_Silent_p.S2109S	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	2222					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TACTTAAGGTCGAAGGTAGCT	0.438000													119	210					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116339264	116339264	+	Silent	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr7:116339264G>A	ENST00000397752.3	+	2	326	c.126G>A	c.(124-126)caG>caA	p.Q42Q	MET_ENST00000436117.2_Silent_p.Q42Q|MET_ENST00000318493.6_Silent_p.Q42Q	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	42	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TGAAGTATCAGCTTCCCAACT	0.453000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				12	96					0	0	1	0	0
MID2	11043	broad.mit.edu	37	X	107084257	107084257	+	Missense_Mutation	SNP	G	G	A	rs147886536		TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chrX:107084257G>A	ENST00000262843.6	+	2	910	c.362G>A	c.(361-363)cGc>cAc	p.R121H	MID2_ENST00000443968.2_Missense_Mutation_p.R121H	NM_012216.3|NM_052817.2	NP_036348.2|NP_438112.2	Q9UJV3	TRIM1_HUMAN	midline 2	121						centrosome|microtubule	ligase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)	19						AGTGAGAGCCGCCGGGAAAGG	0.552000													4	87					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183994719	183994719	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr3:183994719C>T	ENST00000402825.3	+	3	520	c.520C>T	c.(520-522)Cgc>Tgc	p.R174C	ECE2_ENST00000359140.4_Missense_Mutation_p.R27C|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000357474.5_Missense_Mutation_p.R102C|ECE2_ENST00000404464.3_Missense_Mutation_p.R56C	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	174					brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GTTAGGCTCACGCACGCAGCT	0.592000													10	82					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													4	57					0	0	1	0	0
COLGALT2	23127	broad.mit.edu	37	1	183908079	183908079	+	Missense_Mutation	SNP	G	G	A	rs148126558		TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr1:183908079G>A	ENST00000361927.4	-	12	2068	c.1697C>T	c.(1696-1698)cCg>cTg	p.P566L	COLGALT2_ENST00000546159.1_Intron|COLGALT2_ENST00000367521.1_Missense_Mutation_p.P174L|COLGALT2_ENST00000367520.3_Missense_Mutation_p.P303L|COLGALT2_ENST00000486375.1_Intron	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2									p.P566>?(1)									CAGGTACCCCGGCTGGCCTGT	0.552000													9	172					0	0	1	0	0
ZNF622	90441	broad.mit.edu	37	5	16465300	16465300	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr5:16465300C>A	ENST00000308683.2	-	1	601	c.475G>T	c.(475-477)Gtg>Ttg	p.V159L		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	159						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						CCCACGGCCACGACATTCCTG	0.637000													38	48					2.66277e-13	3.07595e-13	1	1	0
OR4K17	390436	broad.mit.edu	37	14	20586543	20586543	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr14:20586543G>T	ENST00000315543.4	+	1	978	c.978G>T	c.(976-978)aaG>aaT	p.K326N		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	298					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		AAGAAATGAAGATATCCATGA	0.378000													5	32					1.23904e-05	1.36091e-05	1	1	0
TTC25	83538	broad.mit.edu	37	17	40094978	40094978	+	RNA	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr17:40094978G>A	ENST00000591658.1	+	0	862							Q96NG3	TTC25_HUMAN	tetratricopeptide repeat domain 25							cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				GACCACAAACGCCGTCCCTCA	0.572000													8	167					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16890488	16890488	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr1:16890488C>T	ENST00000430580.2	-	29	4257	c.3370G>A	c.(3370-3372)Gga>Aga	p.G1124R		NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	0	NBPF 8.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		AGACTTGTTCCCATCAAAGTA	0.478000													73	644					0	0	1	0	0
LAMA5	3911	broad.mit.edu	37	20	60900504	60900504	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr20:60900504G>C	ENST00000252999.3	-	41	5463	c.5397C>G	c.(5395-5397)ttC>ttG	p.F1799L		NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	1799	Laminin IV type A.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGATCTGTGAGAAGAGGGCAC	0.652000													22	57					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													5	38					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111639252	111639252	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr3:111639252G>T	ENST00000431670.2	+	5	2398	c.1987G>T	c.(1987-1989)Ggt>Tgt	p.G663C	PHLDB2_ENST00000393925.3_Missense_Mutation_p.G663C|PHLDB2_ENST00000412622.1_Missense_Mutation_p.G663C|PHLDB2_ENST00000495180.1_Missense_Mutation_p.G249C|PHLDB2_ENST00000481953.1_Missense_Mutation_p.G663C|PHLDB2_ENST00000393923.3_Missense_Mutation_p.G690C	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	663						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GAACATTGTTGGTGAAAAGAC	0.353000													3	67					1	1	1	1	0
OR2T3	343173	broad.mit.edu	37	1	248637422	248637422	+	Silent	SNP	C	C	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr1:248637422C>T	ENST00000359594.2	+	1	796	c.771C>T	c.(769-771)ttC>ttT	p.F257F		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGCTGCTCTTCGGTGCTTCCT	0.552000													17	562					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114270000	114270000	+	Silent	SNP	G	G	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr7:114270000G>A	ENST00000393500.3	+	11	1132	c.312G>A	c.(310-312)caG>caA	p.Q104Q	FOXP2_ENST00000393494.2_Silent_p.Q179Q|FOXP2_ENST00000350908.4_Silent_p.Q179Q|FOXP2_ENST00000393498.2_Silent_p.Q159Q|FOXP2_ENST00000403559.4_Silent_p.Q196Q|AC020606.1_ENST00000580664.1_RNA|FOXP2_ENST00000408937.3_Silent_p.Q204Q|FOXP2_ENST00000378237.3_Silent_p.Q179Q|FOXP2_ENST00000393489.3_Silent_p.Q87Q|FOXP2_ENST00000393491.3_Silent_p.Q87Q|FOXP2_ENST00000390668.3_Silent_p.Q203Q|FOXP2_ENST00000360232.4_Silent_p.Q179Q			O15409	FOXP2_HUMAN	forkhead box P2	179	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q204Q(1)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						agcaacaacagcagcagcagc	0.498000													3	57					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115537600	115537601	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr1:115537600_115537601insA	ENST00000369522.3	+	32	3131_3132	c.2891_2892insA	c.(2890-2892)aaafs	p.K964fs	SYCP1_ENST00000477590.1_3'UTR|SYCP1_ENST00000369518.1_Frame_Shift_Ins_p.K964fs	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	964	Arg/Lys-rich (basic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAATGGATAGAAAAAAAAAAC	0.356													7	91	---	---	---	---					
ZNRD1-AS1	80862	broad.mit.edu	37	6	29970905	29970906	+	RNA	INS	-	-	G	rs139061936	by1000genomes	TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr6:29970905_29970906insG	ENST00000376797.3	-	0	1548				ZNRD1-AS1_ENST00000420251.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA																							gctgaggccctcttcccatggg	0.545													4	2	---	---	---	---					
MTHFSD	64779	broad.mit.edu	37	16	86582173	86582174	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr16:86582173_86582174insT	ENST00000322911.6	-	4	294_295	c.244_245insA	c.(244-246)attfs	p.I82fs	MTHFSD_ENST00000546093.1_5'UTR|MTHFSD_ENST00000360900.6_Frame_Shift_Ins_p.I83fs|MTHFSD_ENST00000381214.5_Frame_Shift_Ins_p.I83fs|MTHFSD_ENST00000568037.1_5'UTR|MTHFSD_ENST00000543303.2_Frame_Shift_Ins_p.I82fs	NM_001159377.1|NM_022764.2	NP_001152849.1|NP_073601.2	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	83					folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						AACCAACAATGTTTTTTTGCTC	0.361													24	61	---	---	---	---					
MAP3K3	4215	broad.mit.edu	37	17	61768562	61768562	+	Frame_Shift_Del	DEL	C	C	-	rs61737830	byFrequency	TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr17:61768562delC	ENST00000361357.3	+	14	1724	c.1406delC	c.(1405-1407)acfs	p.T469fs	MAP3K3_ENST00000579585.1_Frame_Shift_Del_p.T469fs|MAP3K3_ENST00000577395.1_Frame_Shift_Del_p.T434fs|MAP3K3_ENST00000361733.3_Frame_Shift_Del_p.T438fs|MAP3K3_ENST00000584573.1_Frame_Shift_Del_p.T465fs	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	438	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						GCTGAGAAGACCCTGACCATC	0.577													29	170	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	112519	112520	+	RNA	INS	-	-	A	rs140158594	by1000genomes	TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr18:112519_112520insA	ENST00000576266.1	+	0	153_154																											CCAGCTCCCCCGGGGCCTCCGT	0.530													4	5	---	---	---	---					
XPNPEP3	63929	broad.mit.edu	37	22	41282374	41282375	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-8087-01A-11D-2238-08	TCGA-55-8087-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b8ed498f-8517-4b48-87ae-f05fdcd8ac5a	d7a68390-c242-4dac-88fa-8c7ba2193666	g.chr22:41282374_41282375insT	ENST00000357137.4	+	4	731_732	c.647_648insT	c.(646-648)tgafs	p.*216fs	XPNPEP3_ENST00000541156.1_Frame_Shift_Ins_p.*216fs|XPNPEP3_ENST00000414396.1_Frame_Shift_Ins_p.*216fs|XPNPEP3_ENST00000544094.1_Frame_Shift_Ins_p.*193fs	NM_022098.3	NP_071381.1	Q9NQH7	XPP3_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	216					cellular process	mitochondrion	aminopeptidase activity|manganese ion binding|metallopeptidase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	17						CAGCTTCACTCTGACTATATGC	0.485													76	148	---	---	---	---					
