Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC12A2	6558	broad.mit.edu	37	5	127503459	127503459	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:127503459G>T	ENST00000262461.2	+	18	2812	c.2623G>T	c.(2623-2625)Ggt>Tgt	p.G875C	SLC12A2_ENST00000343225.4_Missense_Mutation_p.G875C	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	875					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TTAGGCTGCTGGTCTTGGTCG	0.338000													15	71					2.23348e-06	2.70828e-06	0.500413	1	0
NEB	4703	broad.mit.edu	37	2	152476249	152476249	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:152476249G>C	ENST00000427231.2	-	73	10790	c.10588C>G	c.(10588-10590)Cag>Gag	p.Q3530E	NEB_ENST00000604864.1_Missense_Mutation_p.Q3530E|NEB_ENST00000409198.1_Missense_Mutation_p.Q3287E|NEB_ENST00000172853.10_Missense_Mutation_p.Q3287E|NEB_ENST00000397345.3_Missense_Mutation_p.Q3530E|NEB_ENST00000603639.1_Missense_Mutation_p.Q3530E	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3530					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGACCCAACTGTTTACGATAT	0.463000													11	56					0	0	0.457914	0	0
SCEL	8796	broad.mit.edu	37	13	78130760	78130760	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:78130760C>A	ENST00000535157.1	+	3	243	c.73C>A	c.(73-75)Cgg>Agg	p.R25R	SCEL_ENST00000377246.3_Silent_p.R25R|SCEL_ENST00000349847.3_Silent_p.R25R	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	25					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		GGGAACCACACGGAAGCAGCA	0.428000													50	124					2.12129e-23	3.83754e-23	0.870114	1	0
ZNF720	124411	broad.mit.edu	37	16	31734625	31734625	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:31734625G>T	ENST00000316491.9	+	3	376	c.177G>T	c.(175-177)agG>agT	p.R59S	ZNF720_ENST00000534369.1_Intron|ZNF720_ENST00000398696.3_Intron|ZNF720_ENST00000539915.1_Intron|ZNF720_ENST00000531864.2_Intron|ZNF720_ENST00000399681.3_5'UTR	NM_001130913.1	NP_001124385.1	Q7Z2F6	ZN720_HUMAN	zinc finger protein 720	59	KRAB.				regulation of transcription, DNA-dependent	intracellular	nucleic acid binding			endometrium(1)|kidney(1)|lung(1)|stomach(1)	4						TGGAGCAAAGGAAAGAGCCCT	0.478000													5	16					5.18039e-06	6.20094e-06	0.278610	1	0
TSHZ3	57616	broad.mit.edu	37	19	31768748	31768748	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:31768748C>T	ENST00000240587.4	-	2	2278	c.1951G>A	c.(1951-1953)Ggg>Agg	p.G651R		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	651					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					ATGGGTTCCCCGACTTCGCTG	0.637000													5	14					0	0	0.184627	0	0
C5orf42	65250	broad.mit.edu	37	5	37180279	37180279	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:37180279C>G	ENST00000274258.7	-	28	5804	c.2217G>C	c.(2215-2217)atG>atC	p.M739I	C5orf42_ENST00000508244.1_Missense_Mutation_p.M1859I|C5orf42_ENST00000425232.2_Missense_Mutation_p.M1859I			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1859										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			CTTCAGTTGGCATTCTACTGA	0.254000													4	16					0	0	0.217242	0	0
HUNK	30811	broad.mit.edu	37	21	33371376	33371376	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr21:33371376G>A	ENST00000270112.2	+	11	2384	c.2024G>A	c.(2023-2025)cGc>cAc	p.R675H		NM_014586.1	NP_055401.1	P57058	HUNK_HUMAN	hormonally up-regulated Neu-associated kinase	675					multicellular organismal development|signal transduction		ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|skin(2)|stomach(1)	30						TTAAGGAAGCGCCATCAGAGT	0.607000													5	56					0	0	0.217242	0	0
COL19A1	1310	broad.mit.edu	37	6	70916886	70916886	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:70916886C>A	ENST00000322773.4	+	51	3439	c.3337C>A	c.(3337-3339)Cca>Aca	p.P1113T	COL19A1_ENST00000393344.1_Missense_Mutation_p.P735T	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	1113					cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						TGCCCCAGGCCCACAGGGCCC	0.532000													58	97					4.01556e-35	7.63503e-35	0.870114	1	0
PTCH1	5727	broad.mit.edu	37	9	98240358	98240358	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:98240358C>A	ENST00000430669.2	-	9	1713	c.1128G>T	c.(1126-1128)gtG>gtT	p.V376V	PTCH1_ENST00000421141.1_Silent_p.V291V|PTCH1_ENST00000418258.1_Silent_p.V291V|PTCH1_ENST00000375274.2_Silent_p.V441V|PTCH1_ENST00000331920.6_Silent_p.V442V|PTCH1_ENST00000437951.1_Silent_p.V376V|PTCH1_ENST00000429896.2_Silent_p.V291V			Q13635	PTC1_HUMAN	patched 1	442			F -> S (in BCNS).		embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity	p.A443fs*54(1)		NS(8)|bone(33)|breast(10)|central_nervous_system(95)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(8)|kidney(2)|large_intestine(18)|lung(22)|meninges(1)|oesophagus(3)|ovary(6)|prostate(2)|skin(262)|upper_aerodigestive_tract(11)|urinary_tract(2)|vulva(1)	490		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				AGCCGCTGGCCACGCGGATGA	0.522000													9	45					1.61879e-10	2.25101e-10	0.411799	1	0
ZNF860	344787	broad.mit.edu	37	3	32031962	32031962	+	Missense_Mutation	SNP	A	A	G	rs1808125	by1000genomes	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:32031962A>G	ENST00000360311.4	+	2	1940	c.1391A>G	c.(1390-1392)cAt>cGt	p.H464R		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						AAGACCTTCCATCACAATTCA	0.418000													6	96					0	0	0.217242	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182917	140182917	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:140182917T>A	ENST00000522353.2	+	1	2135	c.2135T>A	c.(2134-2136)gTg>gAg	p.V712E	PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Intron|PCDHA3_ENST00000532566.2_Missense_Mutation_p.V712E|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGTCTGTTGGTGCTCACACTG	0.662000													21	90					0	0	0.639603	0	0
RABGAP1	23637	broad.mit.edu	37	9	125863871	125863871	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:125863871C>G	ENST00000373647.4	+	25	3050	c.2916C>G	c.(2914-2916)tgC>tgG	p.C972W	RABGAP1_ENST00000373643.5_Missense_Mutation_p.C311W	NM_012197.3	NP_036329.3	Q9Y3P9	RBGP1_HUMAN	RAB GTPase activating protein 1	972					cell cycle	centrosome|cytosol|microtubule associated complex	Rab GTPase activator activity|tubulin binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|prostate(4)|stomach(3)|upper_aerodigestive_tract(1)	41						GTGAGCGGTGCCGGGAATTTT	0.453000													10	16					0	0	0.435327	0	0
RP1	6101	broad.mit.edu	37	8	55538036	55538036	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:55538036G>T	ENST00000220676.1	+	4	1742	c.1594G>T	c.(1594-1596)Gaa>Taa	p.E532*		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	532					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTCATCATTAGAAAGAAAAAA	0.333000													8	26					5.18039e-06	6.20094e-06	0.278610	1	0
KMT2C	58508	broad.mit.edu	37	7	151962157	151962157	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:151962157G>T	ENST00000355193.2	-	8	1368	c.1150C>A	c.(1150-1152)Caa>Aaa	p.Q384K	KMT2C_ENST00000262189.6_Missense_Mutation_p.Q384K					lysine (K)-specific methyltransferase 2C									p.Q384E(2)									TCAGGACATTGCCAACCTGCA	0.428000													11	593					1.33834e-09	1.81585e-09	0.557998	1	0
SLC14A2	8170	broad.mit.edu	37	18	43207004	43207004	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:43207004G>C	ENST00000255226.6	+	4	1229	c.413G>C	c.(412-414)gGc>gCc	p.G138A	SLC14A2_ENST00000586448.1_Missense_Mutation_p.G138A	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	138						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCTCTCAGCGGCCTCATCATC	0.562000													30	106					0	0	0.750413	0	0
ATP1A2	477	broad.mit.edu	37	1	160106794	160106794	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:160106794G>T	ENST00000361216.3	+	20	2902	c.2813G>T	c.(2812-2814)cGc>cTc	p.R938L	ATP1A2_ENST00000472488.1_3'UTR|ATP1A2_ENST00000392233.3_Missense_Mutation_p.R938L	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	938					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.R938H(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AAGACCCGCCGCAACTCAGTC	0.602000													92	157					1.46079e-55	2.85518e-55	0.870114	1	0
ZNF75D	7626	broad.mit.edu	37	X	134421548	134421548	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:134421548T>C	ENST00000370766.3	-	7	3763	c.1054A>G	c.(1054-1056)Atg>Gtg	p.M352V	ZNF75D_ENST00000494295.1_Intron|ZNF75D_ENST00000370764.1_Missense_Mutation_p.M257V	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	352					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						TGAAGATCCATAAGTTTTGGA	0.418000													9	18					0	0	0.307466	0	0
CENPT	80152	broad.mit.edu	37	16	67863681	67863681	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:67863681G>A	ENST00000562787.1	-	12	1721	c.1173C>T	c.(1171-1173)gcC>gcT	p.A391A	CENPT_ENST00000219172.3_Silent_p.A391A|CENPT_ENST00000564817.1_Intron|CENPT_ENST00000440851.2_Silent_p.A391A	NM_025082.3	NP_079358.3	Q96BT3	CENPT_HUMAN	centromere protein T	391					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding			NS(1)|breast(2)|lung(6)|urinary_tract(1)	10		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		CCCTGCCAGAGGCATCCTCAT	0.597000													13	38					0	0	0.457914	0	0
NCOR1P1	149934	broad.mit.edu	37	20	26084307	26084307	+	RNA	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:26084307C>A	ENST00000478176.1	-	0	150					NR_003678.1													p.D37N(1)									AATGCTGGATCCTTTAGAGAA	0.393000													11	38					7.03913e-09	9.43614e-09	0.411799	1	0
MMRN1	22915	broad.mit.edu	37	4	90857595	90857595	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:90857595A>G	ENST00000394980.1	+	7	3083	c.2764A>G	c.(2764-2766)Aaa>Gaa	p.K922E	MMRN1_ENST00000264790.2_Missense_Mutation_p.K922E|MMRN1_ENST00000394981.1_Intron|MMRN1_ENST00000508372.1_Missense_Mutation_p.K664E			Q13201	MMRN1_HUMAN	multimerin 1	922					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TTCGCTTAACAAAACTCTCCA	0.383000													7	22					0	0	0.278610	0	0
FOXD4	2298	broad.mit.edu	37	9	117816	117816	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:117816G>A	ENST00000382500.2	-	1	601	c.304C>T	c.(304-306)Ccg>Tcg	p.P102S		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	102					axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		GGCTTTGCCGGCTGCCGGGCA	0.672000													30	106					0	0	0.804634	0	0
FRMD6	122786	broad.mit.edu	37	14	52192518	52192518	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:52192518G>C	ENST00000395718.2	+	13	1775	c.1490G>C	c.(1489-1491)gGg>gCg	p.G497A	FRMD6_ENST00000553556.1_Missense_Mutation_p.G147A|FRMD6_ENST00000344768.5_Missense_Mutation_p.G505A|FRMD6_ENST00000356218.4_Missense_Mutation_p.G497A|FRMD6_ENST00000554167.1_Missense_Mutation_p.G428A	NM_001267046.1|NM_152330.3	NP_001253975.1|NP_689543.1	Q96NE9	FRMD6_HUMAN	FERM domain containing 6	505						cytoskeleton|mitochondrion|plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(7)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_epithelial(31;0.0163)|Breast(41;0.089)					AAAGAAATTGGGTCTTCCACC	0.353000													20	49					0	0	0.693898	0	0
SLC22A12	116085	broad.mit.edu	37	11	64360331	64360331	+	Silent	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:64360331T>A	ENST00000377574.1	+	2	1230	c.483T>A	c.(481-483)gcT>gcA	p.A161A	SLC22A12_ENST00000336464.7_Silent_p.A161A|SLC22A12_ENST00000473690.1_5'UTR|SLC22A12_ENST00000377567.2_Silent_p.A161A|SLC22A12_ENST00000377572.1_Silent_p.A161A	NM_144585.2	NP_653186.2	Q96S37	S22AC_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 12	161					cellular homeostasis|response to drug|urate metabolic process	apical plasma membrane|brush border membrane|integral to membrane	PDZ domain binding|urate transmembrane transporter activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27						TGGGAGCTGCTGCGTGCGGCC	0.642000													50	85					0	0	0.870114	0	0
PDZD2	23037	broad.mit.edu	37	5	31799379	31799379	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:31799379C>A	ENST00000438447.1	+	2	412	c.24C>A	c.(22-24)gcC>gcA	p.A8A	PDZD2_ENST00000282493.3_Silent_p.A8A			O15018	PDZD2_HUMAN	PDZ domain containing 2	8					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						AGGACAATGCCGTGCTGCACC	0.662000													5	40					0.184627	0.187648	0.184627	1	0
APOB	338	broad.mit.edu	37	2	21225921	21225921	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:21225921C>A	ENST00000233242.1	-	29	12500	c.12373G>T	c.(12373-12375)Gat>Tat	p.D4125Y		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4125					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	ACGTCGATATCATCAATTTGC	0.498000													30	114					2.75727e-19	4.72796e-19	0.804634	1	0
TAS2R46	259292	broad.mit.edu	37	12	11214361	11214361	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:11214361G>A	ENST00000533467.1	-	1	532	c.533C>T	c.(532-534)aCg>aTg	p.T178M	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176887.2	NP_795368.2	P59540	T2R46_HUMAN	taste receptor, type 2, member 46	178					sensory perception of taste	cilium membrane|integral to membrane	G-protein coupled receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GATGGTTACCGTTGTATTTGA	0.368000													18	47					0	0	0.639603	0	0
SLC12A5	57468	broad.mit.edu	37	20	44664062	44664062	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:44664062C>A	ENST00000454036.1	+	3	312	c.236C>A	c.(235-237)cCt>cAt	p.P79H	SLC12A5_ENST00000372315.1_Missense_Mutation_p.P56H|SLC12A5_ENST00000539566.1_Missense_Mutation_p.P56H|SLC12A5_ENST00000243964.3_Missense_Mutation_p.P56H	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	79					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GACACCAGCCCTATGGTGTCC	0.577000													79	255					4.66267e-56	9.14538e-56	0.870114	1	0
NXF3	56000	broad.mit.edu	37	X	102334377	102334377	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:102334377G>T	ENST00000395065.3	-	15	1346	c.1245C>A	c.(1243-1245)caC>caA	p.H415Q	NXF3_ENST00000425644.1_Missense_Mutation_p.H87Q|NXF3_ENST00000497850.1_5'UTR	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	415	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						CAAGTTTTGTGTGCTTCAGCA	0.542000													20	77					1.87028e-06	2.29274e-06	0.608945	1	0
TTN	7273	broad.mit.edu	37	2	179610952	179610952	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:179610952G>A	ENST00000360870.5	-	46	16397	c.16175C>T	c.(16174-16176)cCa>cTa	p.P5392L	TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000585451.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	8900	Ig-like 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAATTTTCTGGAATTTTAAA	0.338000													15	31					0	0	0.539581	0	0
GPR35	2859	broad.mit.edu	37	2	241569925	241569925	+	Missense_Mutation	SNP	G	G	T	rs146267919		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:241569925G>T	ENST00000319838.5	+	6	1498	c.556G>T	c.(556-558)Gtg>Ttg	p.V186L	GPR35_ENST00000403859.1_Missense_Mutation_p.V186L|GPR35_ENST00000438013.2_Missense_Mutation_p.V217L|GPR35_ENST00000430267.1_Missense_Mutation_p.V186L|GPR35_ENST00000407714.1_Missense_Mutation_p.V186L	NM_001195381.1	NP_001182310.1	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	186						integral to plasma membrane	G-protein coupled receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(1)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	17		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GCCCCTGGCCGTGGTGGTCTT	0.662000													12	42					1.5739e-10	2.20503e-10	0.500413	1	0
RBMXL2	27288	broad.mit.edu	37	11	7111090	7111090	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:7111090A>T	ENST00000306904.5	+	1	926	c.739A>T	c.(739-741)Agt>Tgt	p.S247C		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	247	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CGGCCACTCCAGTGTCCGGGA	0.647000													14	33					0	0	0.575678	0	0
KBTBD6	89890	broad.mit.edu	37	13	41705410	41705410	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:41705410T>C	ENST00000379485.1	-	1	1472	c.1238A>G	c.(1237-1239)aAt>aGt	p.N413S	KBTBD6_ENST00000499385.2_Missense_Mutation_p.N347S	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	413							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		CTGCCAACTATTCTGAGCTGG	0.498000													44	94					0	0	0.870114	0	0
KIAA1109	84162	broad.mit.edu	37	4	123193363	123193363	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:123193363A>T	ENST00000264501.4	+	48	8622	c.8249A>T	c.(8248-8250)gAa>gTa	p.E2750V	KIAA1109_ENST00000455637.1_Missense_Mutation_p.E2750V|KIAA1109_ENST00000388738.3_Missense_Mutation_p.E2750V			Q2LD37	K1109_HUMAN	KIAA1109	2750					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TTTGAGAATGAACAAGACAAC	0.383000													14	23					0	0	0.479597	0	0
TRIM48	79097	broad.mit.edu	37	11	55036771	55036771	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:55036771C>G	ENST00000417545.2	+	5	718	c.632C>G	c.(631-633)gCa>gGa	p.A211G		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	195						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						GCGCTCAGGGCAGGGCCCATC	0.498000													33	64					0	0	0.864702	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			4	22					0.00116845	0.00127571	0.217242	1	0
GLUD2	2747	broad.mit.edu	37	X	120182418	120182418	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:120182418G>C	ENST00000328078.1	+	1	957	c.880G>C	c.(880-882)Gga>Cga	p.G294R		NM_012084.3	NP_036216.2	P49448	DHE4_HUMAN	glutamate dehydrogenase 2	294					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|urinary_tract(1)	38					L-Glutamic Acid(DB00142)|NADH(DB00157)	GAGCATTTTAGGAATGACACC	0.428000													13	107					0	0	0.435327	0	0
CACNA1F	778	broad.mit.edu	37	X	49079280	49079280	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:49079280G>T	ENST00000376265.2	-	16	2197	c.2136C>A	c.(2134-2136)gaC>gaA	p.D712E	CACNA1F_ENST00000323022.5_Missense_Mutation_p.D701E|CACNA1F_ENST00000376251.1_Missense_Mutation_p.D647E|CACNA1F_ENST00000480889.1_5'UTR	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	712					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	CCACGTTCCAGTCCTCACCTG	0.547000													14	84					5.35267e-07	6.76955e-07	0.557998	1	0
LCLAT1	253558	broad.mit.edu	37	2	30748531	30748531	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:30748531G>T	ENST00000309052.4	+	3	398	c.189G>T	c.(187-189)ctG>ctT	p.L63L	LCLAT1_ENST00000379509.3_Silent_p.L25L|LCLAT1_ENST00000359433.1_Silent_p.L63L|LCLAT1_ENST00000319406.4_Silent_p.L63L|LCLAT1_ENST00000540623.1_Silent_p.L25L|LCLAT1_ENST00000491680.2_Intron	NM_182551.3	NP_872357.2	Q6UWP7	LCLT1_HUMAN	lysocardiolipin acyltransferase 1	63					multicellular organismal development|phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)	19						TTTTCATGCTGAGTCCCTTTT	0.403000													29	59					8.88839e-20	1.53827e-19	0.750413	1	0
PCDH15	65217	broad.mit.edu	37	10	55849794	55849794	+	Silent	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:55849794T>A	ENST00000373965.2	-	17	2362	c.1968A>T	c.(1966-1968)acA>acT	p.T656T	PCDH15_ENST00000414778.1_Silent_p.T654T|PCDH15_ENST00000373957.3_Silent_p.T627T|PCDH15_ENST00000395433.1_Silent_p.T627T|PCDH15_ENST00000409834.1_Silent_p.T260T|PCDH15_ENST00000320301.6_Silent_p.T649T|PCDH15_ENST00000395446.1_Silent_p.T649T|PCDH15_ENST00000395430.1_Silent_p.T649T|PCDH15_ENST00000361849.3_Silent_p.T649T|PCDH15_ENST00000373955.1_Silent_p.T649T|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395438.1_Silent_p.T649T|PCDH15_ENST00000437009.1_Intron|PCDH15_ENST00000395432.2_Silent_p.T612T|PCDH15_ENST00000395445.1_Silent_p.T656T|PCDH15_ENST00000395442.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	649	Cadherin 6.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CAATGGCATATGTTATTGAGT	0.338000										HNSCC(58;0.16)			10	44					0	0	0.411799	0	0
TSSK1B	83942	broad.mit.edu	37	5	112770510	112770510	+	Silent	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:112770510T>A	ENST00000390666.3	-	1	218	c.27A>T	c.(25-27)cgA>cgT	p.R9R	CTD-2201G3.1_ENST00000416046.2_RNA|MCC_ENST00000408903.3_Intron|CTD-2201G3.1_ENST00000383058.4_RNA	NM_032028.3	NP_114417.1	Q9BXA7	TSSK1_HUMAN	testis-specific serine kinase 1B	9					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(8)|ovary(2)|skin(2)|stomach(1)	13		all_cancers(142;0.0138)|all_epithelial(76;0.000445)|Colorectal(10;0.00814)|Prostate(80;0.0115)|Ovarian(225;0.156)		Epithelial(69;4.15e-08)|OV - Ovarian serous cystadenocarcinoma(64;4.49e-08)|all cancers(49;3.2e-06)|COAD - Colon adenocarcinoma(37;0.0371)|Colorectal(14;0.0449)		GGTAGCCTCGTCGCTTGAGGA	0.552000													7	56					0	0	0.335167	0	0
SLC38A7	55238	broad.mit.edu	37	16	58709954	58709954	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:58709954T>A	ENST00000570101.1	-	7	1656	c.773A>T	c.(772-774)cAc>cTc	p.H258L	SLC38A7_ENST00000564010.1_Missense_Mutation_p.H169L|SLC38A7_ENST00000564100.1_Missense_Mutation_p.H258L|SLC38A7_ENST00000566953.1_5'UTR|SLC38A7_ENST00000219320.4_Missense_Mutation_p.H258L			Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	258					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	13						ACTGCTGACGTGGCACTGTCC	0.577000													9	32					0	0	0.361761	0	0
TNXB	7148	broad.mit.edu	37	6	32011570	32011570	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:32011570C>T	ENST00000375244.3	-	35	11687	c.11486G>A	c.(11485-11487)cGa>cAa	p.R3829Q	TNXB_ENST00000451343.1_Missense_Mutation_p.R258Q|TNXB_ENST00000375247.2_Missense_Mutation_p.R3827Q			P22105	TENX_HUMAN	tenascin XB	3874	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CTCAAAGCCTCGGACCGAGAC	0.642000													46	105					0	0	0.870114	0	0
GCM2	9247	broad.mit.edu	37	6	10874994	10874994	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:10874994C>G	ENST00000379491.4	-	5	902	c.755G>C	c.(754-756)gGa>gCa	p.G252A	RP11-637O19.3_ENST00000480294.1_Intron|SYCP2L_ENST00000543878.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	252					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				CATTTTGTCTCCTTGAAAGGT	0.458000													19	70					0	0	0.592651	0	0
FOXS1	2307	broad.mit.edu	37	20	30433280	30433280	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:30433280G>A	ENST00000375978.3	-	1	140	c.66C>T	c.(64-66)agC>agT	p.S22S		NM_004118.3	NP_004109.1	O43638	FOXS1_HUMAN	forkhead box S1	22					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|insulin receptor signaling pathway|lymphangiogenesis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|neural crest cell fate commitment|neuromuscular process controlling balance|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of multicellular organism growth|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|somitogenesis|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	9						GGGCGATGTAGCTGTAGGGAG	0.657000													3	85					0	0	0.217242	0	0
TGM4	7047	broad.mit.edu	37	3	44952588	44952588	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:44952588C>T	ENST00000296125.4	+	12	1813	c.1745C>T	c.(1744-1746)aCg>aTg	p.T582M		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	582					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	GAAGTATTCACGTCTTTCCAG	0.493000													11	29					0	0	0.520397	0	0
AXIN2	8313	broad.mit.edu	37	17	63545648	63545648	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:63545648C>G	ENST00000307078.5	-	3	1259	c.946G>C	c.(946-948)Gac>Cac	p.D316H	CTD-2535L24.2_ENST00000577662.1_3'UTR|AXIN2_ENST00000375702.5_Missense_Mutation_p.D316H	NM_004655.3	NP_004646.3	Q9Y2T1	AXIN2_HUMAN	axin 2	316					cellular protein localization|cellular response to organic cyclic compound|dorsal/ventral axis specification|intramembranous ossification|maintenance of DNA repeat elements|mRNA stabilization|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of osteoblast differentiation|odontogenesis|positive regulation of cell death|positive regulation of epithelial to mesenchymal transition|positive regulation of protein phosphorylation|regulation of centromeric sister chromatid cohesion|regulation of mismatch repair|Wnt receptor signaling pathway involved in somitogenesis	Axin-APC-beta-catenin-GSK3B complex|cell cortex|centrosome|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|nucleus|plasma membrane|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			NS(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	34						ACACTGCTGTCCGTCATGGAC	0.547000									Oligodontia, Ectodermal Dysplasia and Colorectal Polyp syndrome				7	27					0	0	0.307466	0	0
KIF4A	24137	broad.mit.edu	37	X	69624660	69624660	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:69624660A>T	ENST00000374403.3	+	25	2968	c.2886A>T	c.(2884-2886)acA>acT	p.T962T	KIF4A_ENST00000374388.3_Silent_p.T962T	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	962	Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						TGCTGAGCACACTGAAGTGTC	0.473000													6	26					0	0	0.248553	0	0
C1orf194	127003	broad.mit.edu	37	1	109649724	109649724	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:109649724G>A	ENST00000369949.4	-	3	362	c.183C>T	c.(181-183)gaC>gaT	p.D61D	C1orf194_ENST00000369945.3_Silent_p.D34D|C1orf194_ENST00000369948.3_Silent_p.D73D	NM_001122961.1	NP_001116433.1	Q5T5A4	CA194_HUMAN	chromosome 1 open reading frame 194	73										large_intestine(2)|lung(2)|ovary(2)	6						CTAAGCGGAAGTCCAGGTCAT	0.478000													32	80					0	0	0.834066	0	0
TTI1	9675	broad.mit.edu	37	20	36640118	36640118	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:36640118C>A	ENST00000373448.2	-	3	2339	c.2101G>T	c.(2101-2103)Ggg>Tgg	p.G701W	TTI1_ENST00000449821.1_Missense_Mutation_p.G701W|TTI1_ENST00000373447.3_Missense_Mutation_p.G701W	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	701							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						AAAGAGATCCCATTCACTAAA	0.493000													7	30					0.0293803	0.030584	0.248553	1	0
ABCA13	154664	broad.mit.edu	37	7	48311668	48311668	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:48311668G>A	ENST00000435803.1	+	17	2429	c.2405G>A	c.(2404-2406)tGg>tAg	p.W802*		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	802					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						GAAGTGATTTGGAAAATGCAG	0.338000													9	27					0	0	0.387290	0	0
SGCZ	137868	broad.mit.edu	37	8	14095111	14095111	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:14095111C>G	ENST00000382080.1	-	4	1129	c.414G>C	c.(412-414)caG>caC	p.Q138H	SGCZ_ENST00000421524.2_Missense_Mutation_p.Q91H	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta	125					cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		CTATGGTCAGCTGTCCGGTTA	0.413000													185	494					0	0	0.870114	0	0
CARD9	64170	broad.mit.edu	37	9	139266376	139266376	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:139266376G>A	ENST00000371732.5	-	2	320	c.155C>T	c.(154-156)cCc>cTc	p.P52L	CARD9_ENST00000371734.3_Missense_Mutation_p.P52L|CARD9_ENST00000315908.7_Missense_Mutation_p.P52L	NM_052813.4	NP_434700.2	Q9H257	CARD9_HUMAN	caspase recruitment domain family, member 9	52	CARD.				positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of JNK cascade|positive regulation of stress-activated MAPK cascade|regulation of apoptosis	cytoplasm	CARD domain binding|protein homodimerization activity			endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)|prostate(3)|skin(1)	15		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;4.58e-06)|Epithelial(140;5.65e-06)		GACCAGGTTGGGGTCGCTGAG	0.637000													74	193					0	0	0.870114	0	0
OR4C6	219432	broad.mit.edu	37	11	55433000	55433000	+	Missense_Mutation	SNP	C	C	A	rs146965889	byFrequency	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:55433000C>A	ENST00000314259.3	+	1	387	c.358C>A	c.(358-360)Cgc>Agc	p.R120S		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	120					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						GGCCTATGACCGCTACGTGGC	0.552000													25	83					7.92952e-12	1.15734e-11	0.667858	1	0
MEGF8	1954	broad.mit.edu	37	19	42873083	42873083	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:42873083C>T	ENST00000334370.4	+	36	7004	c.6369C>T	c.(6367-6369)aaC>aaT	p.N2123N	MEGF8_ENST00000251268.6_Silent_p.N2190N	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2190	PSI 7.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				ACGACTGCAACGAGACGCAGA	0.672000													8	48					0	0	0.361761	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857926	9857926	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:9857926G>A	ENST00000396573.2	-	14	3784	c.3475C>T	c.(3475-3477)Cgc>Tgc	p.R1159C	GRIN2A_ENST00000396575.2_Missense_Mutation_p.R1159C|GRIN2A_ENST00000562109.1_Missense_Mutation_p.R1159C|GRIN2A_ENST00000404927.2_Missense_Mutation_p.R1159C|GRIN2A_ENST00000330684.3_Missense_Mutation_p.R1159C|GRIN2A_ENST00000535259.1_Missense_Mutation_p.R1002C	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1159					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TCCCCCTTGCGGAAGTTTTCA	0.532000													13	98					0	0	0.435327	0	0
MAP3K2	10746	broad.mit.edu	37	2	128066328	128066328	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:128066328G>T	ENST00000409947.1	-	16	1749	c.1467C>A	c.(1465-1467)atC>atA	p.I489I	MAP3K2_ENST00000344908.5_Silent_p.I489I			Q9Y2U5	M3K2_HUMAN	mitogen-activated protein kinase kinase kinase 2	489	Protein kinase.				activation of JUN kinase activity|cellular response to mechanical stimulus	nucleus	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein kinase binding			central_nervous_system(1)|large_intestine(1)|lung(3)|ovary(2)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0706)		AATCTCGCAGGATATTTGCGC	0.418000													5	35					0.00116845	0.00127571	0.217242	1	0
AFF2	2334	broad.mit.edu	37	X	148037824	148037824	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:148037824G>T	ENST00000370460.2	+	11	2728	c.2249G>T	c.(2248-2250)tGt>tTt	p.C750F	AFF2_ENST00000286437.5_Missense_Mutation_p.C391F|AFF2_ENST00000342251.3_Missense_Mutation_p.C717F|AFF2_ENST00000370457.5_Missense_Mutation_p.C717F	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	750					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					AAGGAAATCTGTGGTGCCAGC	0.463000													8	68					0.000274275	0.000307254	0.307466	1	0
SYNE3	161176	broad.mit.edu	37	14	95884188	95884188	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:95884188C>A	ENST00000334258.5	-	17	2917	c.2903G>T	c.(2902-2904)cGc>cTc	p.R968L	SYNE3_ENST00000554873.1_Missense_Mutation_p.R725L|SYNE3_ENST00000557275.1_Missense_Mutation_p.R963L	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						GCCATTGTAGCGCAGCATGAG	0.622000													90	164					5.9366e-57	1.17264e-56	0.870114	1	0
VN1R2	317701	broad.mit.edu	37	19	53762215	53762215	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:53762215C>A	ENST00000341702.3	+	1	671	c.587C>A	c.(586-588)tCc>tAc	p.S196Y		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	196					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		CCTAGGAACTCCAGGTGGGCA	0.483000													3	21					0.004672	0.00500316	0.115264	1	0
DHRS2	10202	broad.mit.edu	37	14	24108149	24108149	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:24108149A>T	ENST00000250383.6	+	2	552	c.76A>T	c.(76-78)Acc>Tcc	p.T26S	DHRS2_ENST00000553896.1_3'UTR|DHRS2_ENST00000344777.7_Missense_Mutation_p.T26S	NM_005794.3	NP_005785.1	Q13268	DHRS2_HUMAN	dehydrogenase/reductase (SDR family) member 2	4					C21-steroid hormone metabolic process|cellular response to oxidative stress|myeloid dendritic cell differentiation|negative regulation of apoptosis|negative regulation of cell proliferation|response to toxin	mitochondrion|nuclear envelope	binding|carbonyl reductase (NADPH) activity			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14				GBM - Glioblastoma multiforme(265;0.00659)		GATGAGCAGCACCGGGATAGA	0.612000													23	96					0	0	0.693898	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518030	113518030	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:113518030G>T	ENST00000284601.3	-	4	3185	c.3117C>A	c.(3115-3117)taC>taA	p.Y1039*		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	1039					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CACCTGAAGTGTATAGTGATT	0.388000													50	135					5.29962e-57	1.05053e-56	0.870114	1	0
IGKV3D-20	28874	broad.mit.edu	37	2	90078155	90078155	+	RNA	SNP	G	G	C	rs2555984		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:90078155G>C	ENST00000390270.2	+	0	289																											CTGGCCTGGCGCCCAGGCTCC	0.587000													19	44					0	0	0.608945	0	0
BRINP3	339479	broad.mit.edu	37	1	190067320	190067320	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:190067320A>C	ENST00000367462.3	-	8	2360	c.2129T>G	c.(2128-2130)gTa>gGa	p.V710G	FAM5C_ENST00000534846.1_Missense_Mutation_p.V608G|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		710						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GAGTTTATTTACACGGTCTCT	0.483000													13	47					0	0	0.457914	0	0
TLR3	7098	broad.mit.edu	37	4	187004836	187004836	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:187004836A>G	ENST00000296795.2	+	4	2100	c.1996A>G	c.(1996-1998)Acc>Gcc	p.T666A	TLR3_ENST00000504367.1_Missense_Mutation_p.T389A	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	666	LRRCT.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		CGAGACCCATACCAACATCCC	0.438000													33	84					0	0	0.760397	0	0
CACNA1A	773	broad.mit.edu	37	19	13470426	13470426	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:13470426G>T	ENST00000360228.5	-	6	971	c.972C>A	c.(970-972)ctC>ctA	p.L324L	CACNA1A_ENST00000573710.2_Silent_p.L324L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	324					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	TTACATTGTAGAGGAGATCAG	0.537000													7	27					1.58986e-06	1.96189e-06	0.361761	1	0
CSAG4	100130935	broad.mit.edu	37	X	151896606	151896606	+	RNA	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:151896606G>C	ENST00000361201.4	-	0	334					NR_073432.1															endometrium(2)|kidney(2)|lung(1)	5						CTGGAGGCTCGTGGTTTCCTG	0.557000													7	187					0	0	0.335167	0	0
ADAP2	55803	broad.mit.edu	37	17	29283366	29283366	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:29283366C>T	ENST00000330889.3	+	10	1325	c.990C>T	c.(988-990)ctC>ctT	p.L330L	AC091177.1_ENST00000442757.1_RNA|ADAP2_ENST00000580525.1_Silent_p.L336L	NM_018404.2	NP_060874.1	Q9NPF8	ADAP2_HUMAN	ArfGAP with dual PH domains 2	330	PH 2.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						AAGCCGGACTCACCATTGTCA	0.567000													14	65					0	0	0.539581	0	0
ARFGAP2	84364	broad.mit.edu	37	11	47193031	47193031	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:47193031T>C	ENST00000524782.1	-	10	1115	c.887A>G	c.(886-888)gAa>gGa	p.E296G	ARFGAP2_ENST00000395449.3_5'UTR|ARFGAP2_ENST00000426335.2_Missense_Mutation_p.E160G|ARFGAP2_ENST00000319543.6_Missense_Mutation_p.E27G|ARFGAP2_ENST00000419701.2_Missense_Mutation_p.E189G	NM_001242832.1|NM_032389.4	NP_001229761.1|NP_115765.2	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating protein 2	296	Required for interaction with coatomer.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						CTTCTTCCCTTCCAGATTCTG	0.547000													39	77					0	0	0.834066	0	0
PRDM9	56979	broad.mit.edu	37	5	23522872	23522872	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:23522872C>A	ENST00000296682.3	+	8	942	c.760C>A	c.(760-762)Cct>Act	p.P254T		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	254	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						ATCAGGCATCCCTCAGGCTGG	0.582000										HNSCC(3;0.000094)			3	39					1.23904e-05	1.46432e-05	0.184627	1	0
AHNAK2	113146	broad.mit.edu	37	14	105414909	105414909	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:105414909G>A	ENST00000333244.5	-	7	6998	c.6879C>T	c.(6877-6879)gcC>gcT	p.A2293A	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2293						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CATCCAGCTTGGCTCCTGGGG	0.597000													6	294					0	0	0.278610	0	0
DACH1	1602	broad.mit.edu	37	13	72063270	72063270	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:72063270C>A	ENST00000305425.4	-	7	2009	c.1587G>T	c.(1585-1587)ccG>ccT	p.P529P	DACH1_ENST00000359684.2_Silent_p.P581P|DACH1_ENST00000354591.4_Silent_p.P327P|DACH1_ENST00000313174.7_Silent_p.P381P	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	579					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GTGTAGAAAGCGGGGTCTCAT	0.443000													39	138					2.47907e-22	4.44166e-22	0.870114	1	0
NLRP10	338322	broad.mit.edu	37	11	7982542	7982542	+	Missense_Mutation	SNP	A	A	T	rs112986837	byFrequency	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:7982542A>T	ENST00000328600.2	-	2	778	c.617T>A	c.(616-618)gTa>gAa	p.V206E		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	206	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTTGCAGCTTACATAAAAGAC	0.537000													6	40					0	0	0.217242	0	0
OR4A47	403253	broad.mit.edu	37	11	48510651	48510651	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:48510651C>A	ENST00000446524.1	+	1	383	c.307C>A	c.(307-309)Cac>Aac	p.H103N		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						CTTTATCGAGCACATTTTCGG	0.438000													33	76					7.63091e-17	1.26955e-16	0.834066	1	0
PTER	9317	broad.mit.edu	37	10	16526540	16526540	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:16526540G>T	ENST00000378000.1	+	3	403	c.157G>T	c.(157-159)Gtg>Ttg	p.V53L	PTER_ENST00000535784.2_Missense_Mutation_p.V53L|PTER_ENST00000298942.3_Missense_Mutation_p.V53L|PTER_ENST00000423462.2_Missense_Mutation_p.V53L	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related	53					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						AGAACCTATCGTGATGAAAAA	0.438000													9	39					1.08611e-07	1.4054e-07	0.387290	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68249514	68249514	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:68249514C>T	ENST00000347230.4	-	21	4493	c.4355G>A	c.(4354-4356)aGc>aAc	p.S1452N	ZFYVE26_ENST00000555452.1_Missense_Mutation_p.S1452N	NM_015346.3	NP_056161.2	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1452					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		CACAGCACAGCTCAGGACTGC	0.488000													114	282					0	0	0.870114	0	0
TLE1	7088	broad.mit.edu	37	9	84226816	84226816	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:84226816C>A	ENST00000376499.3	-	13	2186	c.1122G>T	c.(1120-1122)atG>atT	p.M374I	TLE1_ENST00000464999.1_5'UTR|TLE1_ENST00000376472.1_Missense_Mutation_p.M49I|TLE1_ENST00000376484.1_Missense_Mutation_p.M49I	NM_005077.3	NP_005068.2	Q04724	TLE1_HUMAN	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	374	Pro/Ser-rich.				negative regulation of Wnt receptor signaling pathway|organ morphogenesis|transcription, DNA-dependent|Wnt receptor signaling pathway		transcription factor binding			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	29						CGTGGGGGACCATCCCAAAAG	0.627000													36	49					8.04919e-23	1.44678e-22	0.870114	1	0
WNT7A	7476	broad.mit.edu	37	3	13860788	13860788	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:13860788C>A	ENST00000285018.4	-	4	1007	c.703G>T	c.(703-705)Gcc>Tcc	p.A235S		NM_004625.3	NP_004616.2	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family, member 7A	235					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	24						ACGTGAACGGCCTCGTTGTAC	0.617000													11	47					1.33987e-11	1.93537e-11	0.361761	1	0
CCKBR	887	broad.mit.edu	37	11	6291344	6291344	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:6291344A>T	ENST00000525462.1	+	3	433	c.430A>T	c.(430-432)Agc>Tgc	p.S144C	CCKBR_ENST00000334619.2_Missense_Mutation_p.S144C|CCKBR_ENST00000532715.1_Missense_Mutation_p.S60C|CCKBR_ENST00000525014.1_3'UTR			P32239	GASR_HUMAN	cholecystokinin B receptor	134					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GTCCACGCTAAGCCTCGTGGC	0.587000													17	45					0	0	0.592651	0	0
MYH3	4621	broad.mit.edu	37	17	10535299	10535299	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:10535299C>A	ENST00000583535.1	-	35	5078	c.4991G>T	c.(4990-4992)gGc>gTc	p.G1664V	MYH3_ENST00000226209.7_Missense_Mutation_p.G1664V	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1664				RG -> QT (in Ref. 3; CAA31492).	muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						GTCCTCCTGGCCCCGGAGGGC	0.592000													13	54					2.32078e-09	3.12607e-09	0.479597	1	0
THOC2	57187	broad.mit.edu	37	X	122778712	122778712	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:122778712G>T	ENST00000245838.8	-	14	1508	c.1477C>A	c.(1477-1479)Cca>Aca	p.P493T	THOC2_ENST00000355725.4_Missense_Mutation_p.P493T|THOC2_ENST00000491737.1_Missense_Mutation_p.P378T	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	493					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						GAAAGAGATGGAAGTAGTACC	0.328000													7	86					0.000157383	0.000178092	0.278610	1	0
A2M	2	broad.mit.edu	37	12	9265053	9265053	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:9265053C>T	ENST00000318602.7	-	3	657	c.350G>A	c.(349-351)cGg>cAg	p.R117Q		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	117					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	CACTGTGGTCCGCTTCTTAAA	0.463000													9	29					0	0	0.307466	0	0
ATP13A4	84239	broad.mit.edu	37	3	193130049	193130049	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:193130049C>T	ENST00000342695.4	-	27	3448	c.3126G>A	c.(3124-3126)tgG>tgA	p.W1042*	ATP13A4_ENST00000400270.2_Nonsense_Mutation_p.W58*|ATP13A4_ENST00000482964.1_5'UTR|ATP13A4_ENST00000392443.3_Nonsense_Mutation_p.W1023*	NM_032279.2	NP_115655.2	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1042					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(27)|ovary(2)|prostate(3)|skin(11)|upper_aerodigestive_tract(2)	71	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TTCCCAAGAACCAGACTGTAG	0.388000													49	87					0	0	0.870114	0	0
SLC26A2	1836	broad.mit.edu	37	5	149360182	149360182	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:149360182A>T	ENST00000286298.4	+	3	1294	c.1026A>T	c.(1024-1026)gcA>gcT	p.A342A		NM_000112.3	NP_000103.2	P50443	S26A2_HUMAN	solute carrier family 26 (anion exchanger), member 2	342						integral to plasma membrane|membrane fraction	secondary active sulfate transmembrane transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(1)|prostate(2)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			TTGTTGTAGCAGCCACATTAG	0.383000													16	43					0	0	0.539581	0	0
SYT1	6857	broad.mit.edu	37	12	79689995	79689995	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:79689995C>A	ENST00000261205.4	+	7	1278	c.621C>A	c.(619-621)ttC>ttA	p.F207L	SYT1_ENST00000457153.2_Missense_Mutation_p.F204L|SYT1_ENST00000552744.1_Missense_Mutation_p.F207L|SYT1_ENST00000393240.3_Missense_Mutation_p.F207L	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	207	C2 1.|Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						ATCCTGTCTTCAATGAGCAAT	0.353000													9	29					6.40141e-05	7.42404e-05	0.387290	1	0
NKRF	55922	broad.mit.edu	37	X	118724896	118724896	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:118724896C>A	ENST00000371527.1	-	2	1144	c.492G>T	c.(490-492)gaG>gaT	p.E164D	NKRF_ENST00000304449.5_Missense_Mutation_p.E164D|NKRF_ENST00000542113.1_Missense_Mutation_p.E179D|NKRF_ENST00000487600.1_Intron	NM_001173488.1	NP_001166959.1	O15226	NKRF_HUMAN	NFKB repressing factor	164	Active repression domain.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|double-stranded RNA binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(1)|urinary_tract(1)	30						CTACCACAGACTCGGGAAATG	0.438000													13	99					6.31663e-08	8.26931e-08	0.479597	1	0
PKHD1	5314	broad.mit.edu	37	6	51897848	51897848	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:51897848C>T	ENST00000371117.3	-	29	3619	c.3344G>A	c.(3343-3345)aGa>aAa	p.R1115K	PKHD1_ENST00000340994.4_Missense_Mutation_p.R1115K	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1115	IPT/TIG 6; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GCTTATGTTTCTGCTCAGAGT	0.373000													10	51					0	0	0.361761	0	0
UNC5CL	222643	broad.mit.edu	37	6	41000739	41000739	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:41000739T>A	ENST00000244565.3	-	4	921	c.833A>T	c.(832-834)cAg>cTg	p.Q278L	UNC5CL_ENST00000373164.1_Missense_Mutation_p.Q278L	NM_173561.2	NP_775832.2	Q8IV45	UN5CL_HUMAN	unc-5 homolog C (C. elegans)-like	278	Interaction with RELA and NFKB1.				signal transduction	cytoplasm|integral to membrane				endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					CAGTGCCCACTGCAGGGCGCA	0.627000													6	10					0	0	0.217242	0	0
FUNDC2	65991	broad.mit.edu	37	X	154280018	154280018	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:154280018A>T	ENST00000369498.3	+	4	688	c.434A>T	c.(433-435)cAg>cTg	p.Q145L	FUNDC2_ENST00000484175.1_3'UTR	NM_023934.3	NP_076423.2	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	145						mitochondrion				breast(2)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	13	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					GCCAAAGAGCAGCTGAAGATC	0.453000													12	45					0	0	0.457914	0	0
DMBT1	1755	broad.mit.edu	37	10	124377624	124377624	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:124377624C>A	ENST00000368909.3	+	38	4702	c.4596C>A	c.(4594-4596)acC>acA	p.T1532T	DMBT1_ENST00000359586.6_Silent_p.T383T|DMBT1_ENST00000330163.4_Silent_p.T904T|DMBT1_ENST00000368955.3_Silent_p.T1522T|DMBT1_ENST00000368956.2_Silent_p.T904T|DMBT1_ENST00000344338.3_Silent_p.T1522T|DMBT1_ENST00000338354.3_Silent_p.T1532T	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1532	SRCR 12.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CCTGGGGCACCGTGTGTGATG	0.597000													119	342					1.13993e-56	2.24374e-56	0.870114	1	0
OR52L1	338751	broad.mit.edu	37	11	6008051	6008051	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:6008051C>G	ENST00000332249.4	-	1	164	c.110G>C	c.(109-111)gGt>gCt	p.G37A		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTCCTCTAAACCTGGAATCCC	0.473000													7	25					0	0	0.248553	0	0
ZNF343	79175	broad.mit.edu	37	20	2464392	2464392	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:2464392C>A	ENST00000278772.4	-	6	1702	c.1215G>T	c.(1213-1215)ggG>ggT	p.G405G	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						AAGGCTTCTCCCCTGAGTGTA	0.493000													13	50					4.75885e-15	7.51468e-15	0.520397	1	0
RPTN	126638	broad.mit.edu	37	1	152127816	152127816	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:152127816G>T	ENST00000316073.3	-	3	1823	c.1759C>A	c.(1759-1761)Cag>Aag	p.Q587K		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	587	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TCCCCAGTCTGTGATTGAATA	0.463000													39	387					1.48734e-19	2.56611e-19	0.864702	1	0
SLITRK4	139065	broad.mit.edu	37	X	142717426	142717426	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:142717426C>A	ENST00000381779.4	-	2	1724	c.1499G>T	c.(1498-1500)aGa>aTa	p.R500I	SLITRK4_ENST00000338017.4_Missense_Mutation_p.R500I|SLITRK4_ENST00000356928.1_Missense_Mutation_p.R500I	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	500						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					CAGGTTCAGTCTAGCTAAGGG	0.458000													23	166					5.61819e-17	9.4029e-17	0.693898	1	0
RETSAT	54884	broad.mit.edu	37	2	85576623	85576623	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:85576623C>T	ENST00000295802.4	-	5	993	c.881G>A	c.(880-882)gGg>gAg	p.G294E	RETSAT_ENST00000457495.2_Missense_Mutation_p.G233E|RETSAT_ENST00000263854.6_Missense_Mutation_p.G294E	NM_017750.3	NP_060220.3	Q6NUM9	RETST_HUMAN	retinol saturase (all-trans-retinol 13,14-reductase)	294					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	30					Vitamin A(DB00162)	ACTGGAACCCCCTCGGGGATA	0.572000													21	58					0	0	0.639603	0	0
TST	7263	broad.mit.edu	37	22	37407367	37407367	+	Splice_Site	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:37407367C>A	ENST00000403892.3	-	2	1330		c.e2-1		TST_ENST00000249042.3_Splice_Site	NM_001270483.1	NP_001257412.1	Q16762	THTR_HUMAN	thiosulfate sulfurtransferase (rhodanese)						cyanate catabolic process|rRNA transport	mitochondrial matrix|plasma membrane	5S rRNA binding|thiosulfate sulfurtransferase activity			kidney(1)|large_intestine(1)|lung(2)|prostate(1)|skin(1)|urinary_tract(1)	7						GAGTCCAGTCCTGGGCAGGGC	0.562000													11	30					1.5739e-10	2.20503e-10	0.500413	1	0
KCNS2	3788	broad.mit.edu	37	8	99440748	99440748	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:99440748G>A	ENST00000287042.4	+	2	891	c.541G>A	c.(541-543)Ggc>Agc	p.G181S	KCNS2_ENST00000521839.1_Missense_Mutation_p.G181S	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	181						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			GGACAACCCCGGCTACTCAGT	0.582000													10	39					0	0	0.457914	0	0
TBC1D21	161514	broad.mit.edu	37	15	74173742	74173742	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:74173742G>T	ENST00000300504.2	+	2	146	c.63G>T	c.(61-63)gtG>gtT	p.V21V	TBC1D21_ENST00000535547.2_Intron|TBC1D21_ENST00000562056.1_Silent_p.V21V	NM_153356.1	NP_699187.1	Q8IYX1	TBC21_HUMAN	TBC1 domain family, member 21	21						intracellular	Rab GTPase activator activity			breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	17						TTTGCCAGGTGAAGAGAAAAC	0.418000													4	17					0.00909568	0.00962971	0.150653	1	0
TAZ	6901	broad.mit.edu	37	X	153649030	153649030	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:153649030G>C	ENST00000299328.5	+	10	1022	c.733G>C	c.(733-735)Gcc>Ccc	p.A245P	TAZ_ENST00000351413.4_Missense_Mutation_p.A231P|TAZ_ENST00000498029.1_3'UTR|TAZ_ENST00000369776.4_Missense_Mutation_p.A215P|TAZ_ENST00000350743.4_Missense_Mutation_p.A215P|TAZ_ENST00000369790.4_Missense_Mutation_p.A201P	NM_000116.3	NP_000107.1	Q16635	TAZ_HUMAN	tafazzin	245					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity			lung(1)	1	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCCTTCAGTGCCCTGCCTGT	0.642000													10	89					0	0	0.539581	0	0
CA6	765	broad.mit.edu	37	1	9019038	9019038	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:9019038G>T	ENST00000377443.2	+	4	482	c.478G>T	c.(478-480)Gct>Tct	p.A160S	CA6_ENST00000476083.1_3'UTR|CA6_ENST00000377436.3_Missense_Mutation_p.A160S|CA6_ENST00000377442.2_Missense_Mutation_p.A100S	NM_001215.3	NP_001206.2	P23280	CAH6_HUMAN	carbonic anhydrase VI	160					one-carbon metabolic process	extracellular region	carbonate dehydratase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)|skin(5)	16	Ovarian(185;0.112)|all_lung(157;0.143)	all_epithelial(116;1.02e-19)|all_lung(118;3.6e-06)|Lung NSC(185;7.94e-06)|Renal(390;0.000147)|Breast(348;0.00123)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.9e-07)|COAD - Colon adenocarcinoma(227;8.28e-05)|Kidney(185;0.000268)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|STAD - Stomach adenocarcinoma(132;0.00184)|BRCA - Breast invasive adenocarcinoma(304;0.00192)|READ - Rectum adenocarcinoma(331;0.0649)		GGATGGTTTGGCTGTACTGGC	0.438000													26	124					1.7881e-09	2.42022e-09	0.729181	1	0
LLGL2	3993	broad.mit.edu	37	17	73539528	73539528	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:73539528A>T	ENST00000392550.3	+	2	138	c.21A>T	c.(19-21)ccA>ccT	p.P7P	LLGL2_ENST00000578363.1_Silent_p.P7P|LLGL2_ENST00000577200.1_Silent_p.P7P|LLGL2_ENST00000375227.4_Silent_p.P7P|LLGL2_ENST00000167462.5_Silent_p.P7P	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	7					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			TCCTGAGGCCAGGGCATGACC	0.577000													19	57					0	0	0.624587	0	0
POF1B	79983	broad.mit.edu	37	X	84560850	84560850	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:84560850C>G	ENST00000262753.4	-	13	1529	c.1384G>C	c.(1384-1386)Gag>Cag	p.E462Q	POF1B_ENST00000373145.3_Missense_Mutation_p.E462Q	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	462							actin binding	p.E462*(1)		central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TTTACCATCTCCGTGTAGTGG	0.408000													12	66					0	0	0.435327	0	0
UPP2	151531	broad.mit.edu	37	2	158962622	158962622	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:158962622T>C	ENST00000605860.1	+	5	291	c.245T>C	c.(244-246)gTt>gCt	p.V82A	UPP2_ENST00000460456.1_3'UTR|UPP2_ENST00000005756.4_Missense_Mutation_p.V25A|UPP2_ENST00000409859.4_Missense_Mutation_p.V82A			O95045	UPP2_HUMAN	uridine phosphorylase 2	25					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage|uridine metabolic process	cytosol|type III intermediate filament	uridine phosphorylase activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31						AAAAGGTTTGTTCACGTTAAA	0.323000													6	10					0	0	0.217242	0	0
AMER1	139285	broad.mit.edu	37	X	63412377	63412377	+	Missense_Mutation	SNP	C	C	G	rs150929706	byFrequency	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:63412377C>G	ENST00000330258.3	-	2	1062	c.790G>C	c.(790-792)Gcc>Ccc	p.A264P	AMER1_ENST00000403336.1_Missense_Mutation_p.A264P|AMER1_ENST00000374869.3_Missense_Mutation_p.A264P	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									GAGGCACAGGCCTCCATGGGT	0.552000													12	67					0	0	0.387290	0	0
RIMS2	9699	broad.mit.edu	37	8	104922378	104922378	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:104922378C>G	ENST00000507740.1	+	3	1301	c.1065C>G	c.(1063-1065)aaC>aaG	p.N355K	RIMS2_ENST00000262231.10_Intron|RIMS2_ENST00000406091.3_Missense_Mutation_p.N547K|RIMS2_ENST00000436393.2_Missense_Mutation_p.N325K	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	614					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGGATTACAACTGGTTGGATC	0.398000										HNSCC(12;0.0054)			28	112					0	0	0.834066	0	0
CLEC3B	7123	broad.mit.edu	37	3	45077404	45077404	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:45077404C>A	ENST00000296130.4	+	3	777	c.597C>A	c.(595-597)ttC>ttA	p.F199L	CLEC3B_ENST00000490386.1_3'UTR|CLEC3B_ENST00000428034.1_Missense_Mutation_p.F157L	NM_003278.2	NP_003269.2	P05452	TETN_HUMAN	C-type lectin domain family 3, member B	199					skeletal system development	extracellular space	protein binding|sugar binding			endometrium(1)|lung(3)	4				BRCA - Breast invasive adenocarcinoma(193;0.00863)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCTGCCAGTTCGGGATCGTGT	0.721000													10	22					3.86212e-05	4.49776e-05	0.361761	1	0
PAPLN	89932	broad.mit.edu	37	14	73721605	73721605	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:73721605G>T	ENST00000427855.1	+	14	1608	c.1506G>T	c.(1504-1506)tcG>tcT	p.S502S	PAPLN_ENST00000554301.1_Silent_p.S502S|PAPLN_ENST00000381166.3_Silent_p.S502S|PAPLN_ENST00000340738.5_Silent_p.S475S|PAPLN_ENST00000555445.1_Silent_p.S502S			O95428	PPN_HUMAN	papilin, proteoglycan-like sulfated glycoprotein	502	TSP type-1 5.					proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase inhibitor activity|zinc ion binding			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|pancreas(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(3)	42				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.0468)		GCTGCAGCTCGGGCACTCGGA	0.657000													12	40					1.67942e-08	2.23522e-08	0.539581	1	0
LGSN	51557	broad.mit.edu	37	6	64004924	64004924	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:64004924C>A	ENST00000370658.5	-	2	90	c.57G>T	c.(55-57)gaG>gaT	p.E19D	LGSN_ENST00000370657.4_Missense_Mutation_p.E19D	NM_001143940.1|NM_016571.2	NP_001137412.1|NP_057655.2	Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	19					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	TGGCTTCAGTCTCATTGCCTT	0.348000													12	26					0.00185496	0.00201736	0.435327	1	0
NEUROD1	4760	broad.mit.edu	37	2	182543431	182543431	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:182543431G>A	ENST00000295108.3	-	2	614	c.157C>T	c.(157-159)Ctg>Ttg	p.L53L	NEUROD1_ENST00000496876.1_Intron|CERKL_ENST00000479558.1_Intron	NM_002500.4	NP_002491.2	Q13562	NDF1_HUMAN	neuronal differentiation 1	53					amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CCGTTCCTCAGTGAGTCCTCC	0.572000													8	8					0	0	0.278610	0	0
LRRC4	64101	broad.mit.edu	37	7	127670306	127670306	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:127670306G>A	ENST00000249363.3	-	2	645	c.388C>T	c.(388-390)Ctg>Ttg	p.L130L	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	130						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		TTGTCGAACAGCTCCAGGGTG	0.612000													3	63					0	0	0.217242	0	0
CDH9	1007	broad.mit.edu	37	5	26885906	26885906	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:26885906G>T	ENST00000231021.4	-	11	1871	c.1699C>A	c.(1699-1701)Ccg>Acg	p.P567T		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	567	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						ATTAAAATCGGCAATAAGTAG	0.408000													14	25					1.5739e-10	2.20503e-10	0.500413	1	0
VGLL1	51442	broad.mit.edu	37	X	135630860	135630860	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:135630860C>A	ENST00000370634.3	+	3	497	c.327C>A	c.(325-327)ccC>ccA	p.P109P		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					TGCCTGGTCCCATGGCTGTGA	0.582000													208	259					6.15472e-140	1.23759e-139	0.870114	1	0
ZMYM3	9203	broad.mit.edu	37	X	70467599	70467599	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:70467599C>T	ENST00000373998.1	-	12	2830	c.2133G>A	c.(2131-2133)ctG>ctA	p.L711L	ZMYM3_ENST00000314425.5_Silent_p.L711L|ZMYM3_ENST00000373984.3_Silent_p.L713L|ZMYM3_ENST00000489332.1_5'UTR|ZMYM3_ENST00000373988.1_Silent_p.L713L|ZMYM3_ENST00000353904.2_Silent_p.L711L	NM_001171162.1	NP_001164633.1	Q14202	ZMYM3_HUMAN	zinc finger, MYM-type 3	711					multicellular organismal development	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(7)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(17)|ovary(1)|prostate(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(35;0.156)					AGTACCACAGCAGGTACTTGC	0.602000													9	75					0	0	0.435327	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110505897	110505897	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:110505897G>T	ENST00000378402.5	+	63	10348	c.10244G>T	c.(10243-10245)aGa>aTa	p.R3415I		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3415					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TAGATAAATAGAGGGACCAAT	0.348000										HNSCC(38;0.096)			5	27					0.000602214	0.000665292	0.184627	1	0
DRP2	1821	broad.mit.edu	37	X	100503152	100503152	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:100503152G>T	ENST00000395209.3	+	13	1854	c.1327G>T	c.(1327-1329)Gat>Tat	p.D443Y	DRP2_ENST00000402866.1_Missense_Mutation_p.D443Y|DRP2_ENST00000538510.1_Missense_Mutation_p.D443Y|DRP2_ENST00000541709.1_Missense_Mutation_p.D365Y	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	443					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						GCACGTGATGGATGTGGTAGA	0.493000													31	242					4.65686e-17	7.81738e-17	0.788014	1	0
BAI3	577	broad.mit.edu	37	6	70071380	70071380	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:70071380A>T	ENST00000370598.1	+	29	5036	c.4215A>T	c.(4213-4215)tcA>tcT	p.S1405S	BAI3_ENST00000238918.8_Silent_p.S611S|BAI3_ENST00000546190.1_Silent_p.S369S	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1405					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				AAACTGGATCAACGATATCAA	0.358000													28	39					0	0	0.796494	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33624404	33624404	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:33624404C>A	ENST00000504830.1	-	14	2410	c.2075G>T	c.(2074-2076)gGt>gTt	p.G692V	ADAMTS12_ENST00000352040.3_Intron|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	692	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						CAGGCACACACCGCAGCGATC	0.512000										HNSCC(64;0.19)			9	41					4.68919e-08	6.15319e-08	0.361761	1	0
PLK4	10733	broad.mit.edu	37	4	128807073	128807073	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:128807073C>G	ENST00000270861.5	+	5	822	c.548C>G	c.(547-549)gCc>gGc	p.A183G	PLK4_ENST00000507249.1_Missense_Mutation_p.A183G|PLK4_ENST00000513090.1_Missense_Mutation_p.A151G|PLK4_ENST00000514379.1_Missense_Mutation_p.A142G|PLK4_ENST00000515069.1_Missense_Mutation_p.A183G	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	183	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						CCAGAAATTGCCACTCGAAGT	0.433000													6	52					0	0	0.217242	0	0
MUC16	94025	broad.mit.edu	37	19	8999550	8999550	+	Missense_Mutation	SNP	C	C	A	rs78879019		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:8999550C>A	ENST00000397910.4	-	56	40828	c.40625G>T	c.(40624-40626)gGg>gTg	p.G13542V	MUC16_ENST00000380951.5_Missense_Mutation_p.G183V	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13544	SEA 10.			Missing (in Ref. 3; AAK74120).	cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGGCTGCCCCATCCTTCTT	0.602000													8	28					0.000673444	0.000741054	0.361761	1	0
SNHG14	104472715	broad.mit.edu	37	15	25488705	25488705	+	RNA	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:25488705G>A	ENST00000453082.2	+	0	2332					NR_003343.1																						ACTAGCTGTGGTGAGCACATC	0.587000													10	45					0	0	0.361761	0	0
FGF13	2258	broad.mit.edu	37	X	137715135	137715135	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:137715135T>A	ENST00000315930.6	-	5	1275	c.614A>T	c.(613-615)aAg>aTg	p.K205M	FGF13_ENST00000305414.4_Missense_Mutation_p.K152M|FGF13_ENST00000370603.3_Missense_Mutation_p.K215M|FGF13_ENST00000441825.2_Missense_Mutation_p.K186M|FGF13_ENST00000541469.1_Missense_Mutation_p.K159M	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	205					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					TGATGGCTCCTTGTACATGGC	0.478000													9	66					0	0	0.387290	0	0
TBX22	50945	broad.mit.edu	37	X	79286261	79286261	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:79286261C>A	ENST00000442340.1	+	9	1344	c.854C>A	c.(853-855)cCa>cAa	p.P285Q	TBX22_ENST00000373294.5_Missense_Mutation_p.P405Q|TBX22_ENST00000373291.1_Missense_Mutation_p.P285Q|TBX22_ENST00000373296.3_Missense_Mutation_p.P405Q	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	405					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						TCTTTAGCCCCACTCATGATG	0.443000													46	95					4.17328e-34	7.8813e-34	0.870114	1	0
MUC16	94025	broad.mit.edu	37	19	9085906	9085906	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:9085906G>T	ENST00000397910.4	-	1	6112	c.5909C>A	c.(5908-5910)cCa>cAa	p.P1970Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1970	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TACAATTGTTGGTGGGGTGAT	0.453000													14	58					1.99824e-07	2.56196e-07	0.520397	1	0
VGLL1	51442	broad.mit.edu	37	X	135630861	135630861	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:135630861A>T	ENST00000370634.3	+	3	498	c.328A>T	c.(328-330)Atg>Ttg	p.M110L		NM_016267.3	NP_057351.1	Q99990	VGLL1_HUMAN	vestigial like 1 (Drosophila)	110					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Acute lymphoblastic leukemia(192;0.000127)					GCCTGGTCCCATGGCTGTGAA	0.577000													207	259					0	0	0.870114	0	0
SLC2A5	6518	broad.mit.edu	37	1	9098009	9098009	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:9098009T>C	ENST00000377424.4	-	11	1428	c.1249A>G	c.(1249-1251)Agt>Ggt	p.S417G	SLC2A5_ENST00000536305.1_Missense_Mutation_p.S358G|SLC2A5_ENST00000535586.1_Missense_Mutation_p.S302G	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	417					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CAGTGCACACTGCCCCCCACC	0.632000													10	29					0	0	0.411799	0	0
XIST	7503	broad.mit.edu	37	X	73064384	73064384	+	RNA	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:73064384G>T	ENST00000429829.1	-	0	8204					NR_001564.2																						ATGCATGGTTGTGGTCACTTA	0.443000													17	33					5.35267e-07	6.76955e-07	0.557998	1	0
MEGF8	1954	broad.mit.edu	37	19	42866301	42866301	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:42866301G>A	ENST00000334370.4	+	32	6214	c.5579G>A	c.(5578-5580)cGt>cAt	p.R1860H	MEGF8_ENST00000251268.6_Missense_Mutation_p.R1927H	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1927						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GAATGTCGACGTCTCCGGACC	0.652000													8	7					0	0	0.361761	0	0
ATP2B2	491	broad.mit.edu	37	3	10400407	10400407	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:10400407C>A	ENST00000397077.1	-	13	2544	c.1969G>T	c.(1969-1971)Gtg>Ttg	p.V657L	ATP2B2_ENST00000343816.4_Missense_Mutation_p.V688L|ATP2B2_ENST00000383800.4_Missense_Mutation_p.V657L|ATP2B2_ENST00000360273.2_Missense_Mutation_p.V702L|ATP2B2_ENST00000352432.4_Missense_Mutation_p.V702L			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	702					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						ATGCCCACCACGCAGATGCAG	0.657000													11	45					0.00185496	0.00201736	0.435327	1	0
KRT2	3849	broad.mit.edu	37	12	53041550	53041550	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:53041550C>G	ENST00000309680.3	-	6	1233	c.1212G>C	c.(1210-1212)caG>caC	p.Q404H		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	404	Coil 2.|Rod.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		CCTGCAGCCTCTGGATCACGC	0.587000													9	23					0	0	0.361761	0	0
IGHV3-15	28448	broad.mit.edu	37	14	106610477	106610477	+	RNA	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:106610477C>A	ENST00000390603.2	-	0	272																											CCAACCCACTCCAGCCCCTTC	0.532000													27	105					2.09667e-21	3.69727e-21	0.788014	1	0
MAP1LC3C	440738	broad.mit.edu	37	1	242161881	242161881	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:242161881C>A	ENST00000357246.3	-	3	220	c.156G>T	c.(154-156)ccG>ccT	p.P52P		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	52					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			TTTTGTCCAGCGGGGGCAGGA	0.587000											OREG0014354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	88					6.38683e-12	9.42015e-12	0.729181	1	0
GLA	2717	broad.mit.edu	37	X	100656784	100656784	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:100656784C>T	ENST00000218516.3	-	3	404	c.383G>A	c.(382-384)gGa>gAa	p.G128E	GLA_ENST00000493905.1_5'UTR|RPL36A-HNRNPH2_ENST00000409170.3_Intron	NM_000169.2	NP_000160.1	P06280	AGAL_HUMAN	galactosidase, alpha	128			G -> E (in FD).		glycoside catabolic process|glycosphingolipid catabolic process|glycosylceramide catabolic process|negative regulation of nitric oxide biosynthetic process|negative regulation of nitric-oxide synthase activity|oligosaccharide metabolic process	extracellular region|Golgi apparatus|lysosome	cation binding|protein homodimerization activity|raffinose alpha-galactosidase activity|receptor binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(8)	14					Agalsidase beta(DB00103)	TAGCTTCAGTCCTTTGCTGTG	0.478000													15	85					0	0	0.575678	0	0
PDE1A	5136	broad.mit.edu	37	2	183104954	183104954	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:183104954C>G	ENST00000435564.1	-	3	481	c.281G>C	c.(280-282)cGg>cCg	p.R94P	PDE1A_ENST00000456212.1_Missense_Mutation_p.R94P|PDE1A_ENST00000331935.6_Missense_Mutation_p.R94P|PDE1A_ENST00000351439.5_Missense_Mutation_p.R78P|PDE1A_ENST00000410103.1_Missense_Mutation_p.R94P|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000536095.1_5'UTR|PDE1A_ENST00000346717.4_Missense_Mutation_p.R60P|PDE1A_ENST00000409365.1_Missense_Mutation_p.R78P|PDE1A_ENST00000358139.2_Missense_Mutation_p.R94P	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	94					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			CAACCAGTCCCGGACTTCAGA	0.393000													35	66					0	0	0.870114	0	0
GREM2	64388	broad.mit.edu	37	1	240656703	240656703	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:240656703G>T	ENST00000318160.4	-	2	339	c.73C>A	c.(73-75)Cgg>Agg	p.R25R		NM_022469.3	NP_071914.3	Q9H772	GREM2_HUMAN	gremlin 2, DAN family BMP antagonist	25					BMP signaling pathway	extracellular space	cytokine activity			endometrium(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	10		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			CCCGCCGGCCGGTTCTTCCGG	0.622000													4	10					0.014758	0.0155362	0.184627	1	0
CARD16	114769	broad.mit.edu	37	11	104915260	104915260	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:104915260G>A	ENST00000375706.2	-	2	150	c.133C>T	c.(133-135)Cgt>Tgt	p.R45C	CARD16_ENST00000375704.3_Missense_Mutation_p.R45C|CASP1_ENST00000598974.1_Intron|CASP1_ENST00000593315.1_Intron|CASP1_ENST00000415981.2_Intron|CARD16_ENST00000525374.1_Missense_Mutation_p.R45C|CASP1_ENST00000594519.1_Intron	NM_001017534.1	NP_001017534.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						GCATTTTCACGTTTTACTTTC	0.418000													31	187					0	0	0.827153	0	0
KDM5C	8242	broad.mit.edu	37	X	53230809	53230809	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:53230809G>A	ENST00000452825.3	-	12	2315	c.1783C>T	c.(1783-1785)Ctg>Ttg	p.L595L	KDM5C_ENST00000404049.3_Silent_p.L661L|KDM5C_ENST00000375379.3_Silent_p.L662L|KDM5C_ENST00000375383.3_Silent_p.L621L|KDM5C_ENST00000465402.1_5'UTR|KDM5C_ENST00000375401.3_Silent_p.L662L	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	662	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						GCTGCCGCCAGGTTCAGGTCT	0.567000			"""N, F, S"""		clear cell renal carcinoma								7	45					0	0	0.307466	0	0
TRRAP	8295	broad.mit.edu	37	7	98528436	98528436	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:98528436A>G	ENST00000359863.4	+	25	3783	c.3574A>G	c.(3574-3576)Atg>Gtg	p.M1192V	TRRAP_ENST00000446306.3_Missense_Mutation_p.M1191V|TRRAP_ENST00000355540.3_Missense_Mutation_p.M1192V	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	1192					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTTTGTCATGATGGACTTAAC	0.473000													14	24					0	0	0.520397	0	0
SEMA7A	8482	broad.mit.edu	37	15	74708159	74708159	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:74708159A>T	ENST00000261918.4	-	8	1517	c.969T>A	c.(967-969)ggT>ggA	p.G323G	SEMA7A_ENST00000542748.1_Silent_p.G158G|SEMA7A_ENST00000543145.2_Silent_p.G309G	NM_003612.3	NP_003603.1	O75326	SEM7A_HUMAN	semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)	323	Sema.				axon guidance|immune response|inflammatory response|integrin-mediated signaling pathway|positive regulation of axon extension|positive regulation of ERK1 and ERK2 cascade|positive regulation of macrophage cytokine production|regulation of inflammatory response	anchored to membrane|external side of plasma membrane	receptor activity			breast(3)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(3)|lung(12)|upper_aerodigestive_tract(1)	30						TGGAGAAAACACCATAGACCC	0.612000													3	7					0	0	0.115264	0	0
MTR	4548	broad.mit.edu	37	1	237038125	237038125	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:237038125T>A	ENST00000366577.5	+	24	2967	c.2573T>A	c.(2572-2574)aTt>aAt	p.I858N	MTR_ENST00000535889.1_Missense_Mutation_p.I807N	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	858	B12-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CCATTGTTGATTGGAGGAGCA	0.388000													8	67					0	0	0.361761	0	0
PKD1L1	168507	broad.mit.edu	37	7	47968930	47968930	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:47968930G>C	ENST00000289672.2	-	7	981	c.931C>G	c.(931-933)Cgt>Ggt	p.R311G		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	311					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						ATATGAACACGGAATCCCAGA	0.498000													50	153					0	0	0.870114	0	0
DCLRE1C	64421	broad.mit.edu	37	10	14987184	14987184	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:14987184T>A	ENST00000378289.4	-	3	587	c.166A>T	c.(166-168)Aag>Tag	p.K56*	DCLRE1C_ENST00000396817.2_5'UTR|DCLRE1C_ENST00000378246.2_5'UTR|DCLRE1C_ENST00000378254.1_5'UTR|DCLRE1C_ENST00000378255.1_5'UTR|DCLRE1C_ENST00000453695.2_5'UTR|DCLRE1C_ENST00000378278.2_Nonsense_Mutation_p.K56*|DCLRE1C_ENST00000378258.1_5'UTR|DCLRE1C_ENST00000378249.1_5'UTR|DCLRE1C_ENST00000357717.2_Intron			Q96SD1	DCR1C_HUMAN	DNA cross-link repair 1C	56					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)	17						AGATAAACCTTCAAGCTGAAA	0.303000								Non-homologous end-joining					7	19					0	0	0.335167	0	0
F2RL2	2151	broad.mit.edu	37	5	75919025	75919025	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:75919025G>T	ENST00000296641.4	-	1	234	c.31C>A	c.(31-33)Ctc>Atc	p.L11I	IQGAP2_ENST00000502745.1_Intron|IQGAP2_ENST00000396234.3_Intron|F2RL2_ENST00000504899.1_Intron|IQGAP2_ENST00000379730.3_Intron|IQGAP2_ENST00000274364.6_Intron	NM_004101.3	NP_004092.1	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	11					platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(3)	32		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		AGAAGCAGGAGGCCAGCAGCT	0.438000													21	111					9.39395e-14	1.45867e-13	0.706142	1	0
ARPP21	10777	broad.mit.edu	37	3	35770889	35770889	+	Silent	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:35770889T>C	ENST00000187397.4	+	15	1776	c.1320T>C	c.(1318-1320)gcT>gcC	p.A440A	ARPP21_ENST00000337271.5_Silent_p.A386A|ARPP21_ENST00000444190.1_Silent_p.A386A|ARPP21_ENST00000458225.1_Silent_p.A406A|ARPP21_ENST00000417925.1_Silent_p.A406A	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	440						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						GTGTGGCAGCTGGCTCTCCAG	0.597000													16	86					0	0	0.520397	0	0
FAM167B	84734	broad.mit.edu	37	1	32713255	32713255	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:32713255C>T	ENST00000373582.3	+	1	422	c.233C>T	c.(232-234)tCc>tTc	p.S78F		NM_032648.2	NP_116037.2	Q9BTA0	F167B_HUMAN	family with sequence similarity 167, member B	78										endometrium(1)|large_intestine(1)|lung(1)|ovary(2)	5						TCAATGGACTCCGCCCTTGAG	0.652000													5	49					0	0	0.307466	0	0
PDILT	204474	broad.mit.edu	37	16	20396128	20396128	+	Missense_Mutation	SNP	C	C	A	rs141023477		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:20396128C>A	ENST00000302451.4	-	3	496	c.248G>T	c.(247-249)gGc>gTc	p.G83V		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	83					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						CACAGCTTTGCCCAGCTCTTC	0.493000													93	335					6.47804e-62	1.2933e-61	0.870114	1	0
LRP1B	53353	broad.mit.edu	37	2	141665468	141665468	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:141665468G>A	ENST00000389484.3	-	22	4469	c.3498C>T	c.(3496-3498)ggC>ggT	p.G1166G		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1166	LDL-receptor class A 10.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTCATCAGAGCCATCAGGAC	0.423000										TSP Lung(27;0.18)			69	246					0	0	0.870114	0	0
DACH2	117154	broad.mit.edu	37	X	85403942	85403942	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:85403942G>A	ENST00000373131.1	+	1	481	c.318G>A	c.(316-318)ttG>ttA	p.L106L	DACH2_ENST00000373125.4_Silent_p.L106L	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	106	DACHbox-N.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TGGGAGGCTTGCACACTGTGT	0.582000													7	53					0	0	0.278610	0	0
SCN5A	6331	broad.mit.edu	37	3	38622764	38622764	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:38622764G>T	ENST00000413689.1	-	17	3079	c.2886C>A	c.(2884-2886)gcC>gcA	p.A962A	SCN5A_ENST00000333535.4_Silent_p.A962A|SCN5A_ENST00000450102.2_Silent_p.A962A|SCN5A_ENST00000449557.2_Silent_p.A962A|SCN5A_ENST00000423572.2_Silent_p.A962A|SCN5A_ENST00000443581.1_Silent_p.A962A|SCN5A_ENST00000425664.1_Silent_p.A962A|SCN5A_ENST00000414099.2_Silent_p.A962A|SCN5A_ENST00000455624.2_Silent_p.A962A|SCN5A_ENST00000451551.2_Silent_p.A962A	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	962					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGCGGGCCAGGGCCAGCTGGA	0.617000													6	14					0.0215528	0.0225618	0.217242	1	0
OR2AE1	81392	broad.mit.edu	37	7	99473882	99473882	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:99473882T>A	ENST00000316368.2	-	1	798	c.775A>T	c.(775-777)Atg>Ttg	p.M259L		NM_001005276.1	NP_001005276.1	Q8NHA4	O2AE1_HUMAN	olfactory receptor, family 2, subfamily AE, member 1	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(2)	11	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)					CTGGGTCTCATGTAGGAGAAG	0.488000													20	67					0	0	0.624587	0	0
COL23A1	91522	broad.mit.edu	37	5	177690296	177690296	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:177690296C>A	ENST00000390654.3	-	9	909	c.552G>T	c.(550-552)ggG>ggT	p.G184G	COL23A1_ENST00000407622.1_Silent_p.G148G	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1	184	Collagen-like 1.|Gly-rich.					collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		GCCCCGGAGGCCCAGCAGCTC	0.672000													7	7					0.000157383	0.000178092	0.278610	1	0
LHX2	9355	broad.mit.edu	37	9	126794959	126794959	+	Silent	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:126794959A>G	ENST00000373615.4	+	5	1933	c.1194A>G	c.(1192-1194)tcA>tcG	p.S398S		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	398				GHEPHSPSQTTLTNLF -> AMSLTAPHKRLLPTFSNDSQP PHPTISLKKKLSLV (in Ref. 1; AAB08752).		nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						ACAGCCCCTCACAAACGACTC	0.473000													17	40					0	0	0.693898	0	0
PTPRO	5800	broad.mit.edu	37	12	15722369	15722369	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:15722369C>G	ENST00000281171.4	+	19	3096	c.2766C>G	c.(2764-2766)gaC>gaG	p.D922E	PTPRO_ENST00000544244.1_Missense_Mutation_p.D83E|PTPRO_ENST00000445537.2_Missense_Mutation_p.D111E|PTPRO_ENST00000442921.2_Missense_Mutation_p.D111E|PTPRO_ENST00000542557.1_Missense_Mutation_p.D83E|PTPRO_ENST00000348962.2_Missense_Mutation_p.D894E	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	922						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				AACTGGATGACTTTGATGCCT	0.323000													19	60					0	0	0.639603	0	0
MYO18A	399687	broad.mit.edu	37	17	27493073	27493073	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:27493073T>C	ENST00000527372.1	-	2	1066	c.886A>G	c.(886-888)Atc>Gtc	p.I296V	MYO18A_ENST00000354329.4_Missense_Mutation_p.I296V|MYO18A_ENST00000533112.1_Missense_Mutation_p.I296V|MYO18A_ENST00000531253.1_Missense_Mutation_p.I296V	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	296	PDZ.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GACTGCCGGATCATCTCCACA	0.627000													72	172					0	0	0.870114	0	0
OR2L13	284521	broad.mit.edu	37	1	248263605	248263605	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:248263605C>A	ENST00000366478.2	+	3	1265	c.928C>A	c.(928-930)Ctg>Atg	p.L310M	OR2L13_ENST00000358120.2_Missense_Mutation_p.L310M	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			ATTCTCTTTCCTGAAAGAATA	0.448000													9	26					0.0809354	0.0837831	0.387290	1	0
CNR1	1268	broad.mit.edu	37	6	88854124	88854124	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:88854124G>A	ENST00000537554.1	-	2	4432	c.870C>T	c.(868-870)atC>atT	p.I290I	CNR1_ENST00000369499.2_Silent_p.I290I|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000549890.1_Silent_p.I290I|CNR1_ENST00000535130.1_Silent_p.I290I|CNR1_ENST00000428600.2_Silent_p.I290I|CNR1_ENST00000549716.1_Silent_p.I229I|CNR1_ENST00000369501.2_Silent_p.I290I|CNR1_ENST00000468898.1_Silent_p.I257I	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	290					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	ACGCATACACGATGAACAGAA	0.507000													5	17					0	0	0.184627	0	0
C16orf93	90835	broad.mit.edu	37	16	30771695	30771695	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:30771695C>T	ENST00000543610.1	-	4	1340	c.379G>A	c.(379-381)Gcg>Acg	p.A127T	PHKG2_ENST00000424889.3_3'UTR|PHKG2_ENST00000563588.1_3'UTR|C16orf93_ENST00000545825.1_Missense_Mutation_p.A127T|C16orf93_ENST00000541260.1_Missense_Mutation_p.A127T	NM_001014979.2	NP_001014979.2	A1A4V9	CP093_HUMAN	chromosome 16 open reading frame 93	127										breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(6)	11						AAAATGAGCGCGTGGCAGAAG	0.617000													23	58					0	0	0.750413	0	0
UNC5A	90249	broad.mit.edu	37	5	176297417	176297417	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:176297417G>T	ENST00000329542.4	+	6	1042	c.768G>T	c.(766-768)ctG>ctT	p.L256L	UNC5A_ENST00000261961.3_Silent_p.L216L	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	256	TSP type-1.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTGTGGGCTGGACTGCACCC	0.667000													5	30					2.0095e-06	2.44198e-06	0.248553	1	0
MUM1L1	139221	broad.mit.edu	37	X	105449932	105449932	+	Silent	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:105449932A>G	ENST00000337685.2	+	5	1292	c.507A>G	c.(505-507)tcA>tcG	p.S169S	MUM1L1_ENST00000357175.2_Silent_p.S169S|MUM1L1_ENST00000372552.1_Silent_p.S169S	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	169										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATGATAAATCACAAGCACCCA	0.428000													8	17					0	0	0.307466	0	0
NRDE2	55051	broad.mit.edu	37	14	90770427	90770427	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:90770427T>C	ENST00000354366.3	-	5	1089	c.857A>G	c.(856-858)cAg>cGg	p.Q286R	NRDE2_ENST00000357904.3_Missense_Mutation_p.Q55R	NM_017970.3	NP_060440.2			NRDE-2, necessary for RNA interference, domain containing																		TGGAGGACCCTGTCCTTGTAG	0.532000													40	127					0	0	0.870114	0	0
C11orf73	51501	broad.mit.edu	37	11	86013497	86013497	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:86013497G>T	ENST00000533986.1	+	1	245	c.7G>T	c.(7-9)Ggc>Tgc	p.G3C	C11orf73_ENST00000278483.3_Missense_Mutation_p.G3C			Q53FT3	CK073_HUMAN	chromosome 11 open reading frame 73	3						cytoplasm				kidney(1)|large_intestine(1)|urinary_tract(1)	3		Acute lymphoblastic leukemia(157;1.17e-07)|all_hematologic(158;0.000556)				CGCCATGTTTGGCTGCTTGGT	0.637000													3	5					0.150653	0.153678	0.150653	1	0
TRPM8	79054	broad.mit.edu	37	2	234879068	234879068	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:234879068C>G	ENST00000324695.4	+	17	2393	c.2353C>G	c.(2353-2355)Cag>Gag	p.Q785E	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	785						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGAAGTGAGACAGGTAGGGCT	0.532000													44	115					0	0	0.870114	0	0
PCDH7	5099	broad.mit.edu	37	4	30724581	30724581	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:30724581C>A	ENST00000361762.2	+	1	2545	c.1537C>A	c.(1537-1539)Ccc>Acc	p.P513T	PCDH7_ENST00000543491.1_Missense_Mutation_p.P513T	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	513	Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						CTCAGGCAGCCCCAGCCTCTC	0.577000													16	49					5.03518e-11	7.2171e-11	0.557998	1	0
CDH7	1005	broad.mit.edu	37	18	63477136	63477136	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:63477136A>T	ENST00000536984.2	+	3	1101	c.407A>T	c.(406-408)gAg>gTg	p.E136V	CDH7_ENST00000323011.3_Missense_Mutation_p.E136V|CDH7_ENST00000397968.2_Missense_Mutation_p.E136V			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	136	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.E136G(2)		NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GTGGAGCCCGAGTCGGAGTTT	0.522000													14	59					0	0	0.479597	0	0
USP6	9098	broad.mit.edu	37	17	5042761	5042761	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:5042761G>C	ENST00000574788.1	+	22	3520	c.1290G>C	c.(1288-1290)caG>caC	p.Q430H	USP6_ENST00000250066.6_Missense_Mutation_p.Q430H|USP6_ENST00000304328.5_Missense_Mutation_p.Q113H|USP6_ENST00000332776.4_Missense_Mutation_p.Q430H			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	430					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TGGGCACTCAGGGTGTGCCCA	0.632000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								14	56					0	0	0.520397	0	0
LHX5	64211	broad.mit.edu	37	12	113906984	113906984	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:113906984C>A	ENST00000261731.3	-	2	913	c.340G>T	c.(340-342)Gtg>Ttg	p.V114L		NM_022363.2	NP_071758.1	Q9H2C1	LHX5_HUMAN	LIM homeobox 5	114	LIM zinc-binding 2.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	10						TCTTTGCACACGAACTTGTTC	0.562000													4	18					0.014758	0.0155362	0.184627	1	0
ATP8B4	79895	broad.mit.edu	37	15	50279673	50279673	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:50279673C>A	ENST00000284509.6	-	10	804	c.663G>T	c.(661-663)aaG>aaT	p.K221N	ATP8B4_ENST00000559829.1_Missense_Mutation_p.K221N|ATP8B4_ENST00000558959.1_5'UTR	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	221					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TGAGGGAATGCTTGCTGTCTT	0.403000													7	40					0.00621372	0.00662875	0.335167	1	0
LACTB2	51110	broad.mit.edu	37	8	71556476	71556476	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:71556476A>C	ENST00000276590.4	-	4	452	c.416T>G	c.(415-417)gTt>gGt	p.V139G	LACTB2_ENST00000517601.1_5'UTR|LACTB2_ENST00000522447.1_Missense_Mutation_p.V139G|RP11-382J12.1_ENST00000499227.2_Intron|RP11-382J12.1_ENST00000518553.1_Intron	NM_016027.2	NP_057111.1	Q53H82	LACB2_HUMAN	lactamase, beta 2	139							hydrolase activity|metal ion binding			endometrium(2)|large_intestine(1)|liver(1)|lung(4)|ovary(1)|prostate(1)	10	Breast(64;0.0716)		Epithelial(68;0.00319)|all cancers(69;0.0175)|OV - Ovarian serous cystadenocarcinoma(28;0.0628)|BRCA - Breast invasive adenocarcinoma(89;0.166)			GGTATATAGAACTCTGGTTGA	0.368000													26	119					0	0	0.740014	0	0
LILRB1	10859	broad.mit.edu	37	19	55146621	55146621	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:55146621T>A	ENST00000396331.1	+	12	1907	c.1550T>A	c.(1549-1551)cTg>cAg	p.L517Q	LILRB1_ENST00000427581.2_Missense_Mutation_p.L567Q|LILRB1_ENST00000396317.1_Missense_Mutation_p.L501Q|LILRB1_ENST00000396327.3_Missense_Mutation_p.L518Q|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000396332.4_Missense_Mutation_p.L517Q|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000434867.2_Missense_Mutation_p.L517Q|LILRB1_ENST00000396315.1_Missense_Mutation_p.L518Q|LILRB1_ENST00000396321.2_Missense_Mutation_p.L517Q|LILRB1_ENST00000418536.2_Missense_Mutation_p.L501Q|LILRB1_ENST00000324602.7_Missense_Mutation_p.L518Q	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	517					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GACAGAGGCCTGCAGTGGAGG	0.622000										HNSCC(37;0.09)			6	23					0	0	0.387290	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659734	24659734	+	RNA	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:24659734T>C	ENST00000414583.2	+	0	3259					NR_003714.1																						CTCTCTCCTGTGGGAGGGGGG	0.632000													3	8					0	0	0.150653	0	0
TRAV1-1	28693	broad.mit.edu	37	14	22090672	22090672	+	RNA	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:22090672A>T	ENST00000542354.1	+	0	344																											CTCCTTCTACAGGAGCTCCAG	0.448000													10	16					0	0	0.361761	0	0
TTF1	7270	broad.mit.edu	37	9	135275516	135275516	+	Missense_Mutation	SNP	C	C	A	rs148836459		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:135275516C>A	ENST00000334270.2	-	3	1536	c.1497G>T	c.(1495-1497)caG>caT	p.Q499H		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	499					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		GAATGAACTCCTGAAGCTGTT	0.468000													16	94					2.39187e-15	3.79846e-15	0.575678	1	0
GRM1	2911	broad.mit.edu	37	6	146708032	146708032	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:146708032C>A	ENST00000392299.2	+	7	2079	c.1609C>A	c.(1609-1611)Cgg>Agg	p.R537R	GRM1_ENST00000355289.4_Silent_p.R537R|GRM1_ENST00000507907.1_Silent_p.R537R|GRM1_ENST00000492807.2_Silent_p.R537R|GRM1_ENST00000361719.2_Silent_p.R537R|GRM1_ENST00000282753.1_Silent_p.R537R			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	537					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	ATAGGTTATACGGAAAGGAGA	0.373000													9	27					1.08611e-07	1.4054e-07	0.387290	1	0
SV2A	9900	broad.mit.edu	37	1	149885315	149885315	+	Silent	SNP	C	C	A	rs147888576		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:149885315C>A	ENST00000369146.3	-	2	568	c.78G>T	c.(76-78)gcG>gcT	p.A26A	SV2A_ENST00000369145.1_Silent_p.A26A	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	26	Interaction with SYT1 (By similarity).				neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CCTTCTTGGCCGCATGCTTTT	0.547000													25	94					7.01153e-11	9.97315e-11	0.717897	1	0
ADH1A	124	broad.mit.edu	37	4	100212093	100212093	+	Translation_Start_Site	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:100212093G>T	ENST00000209668.2	-	0	92				RP11-696N14.1_ENST00000500358.2_RNA|ADH1A_ENST00000511656.1_5'UTR|RP11-696N14.1_ENST00000509939.1_RNA	NM_000667.3	NP_000658.1	P07327	ADH1A_HUMAN	alcohol dehydrogenase 1A (class I), alpha polypeptide						ethanol oxidation|transcription, DNA-dependent|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|protein binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)	25				OV - Ovarian serous cystadenocarcinoma(123;9.56e-08)	Fomepizole(DB01213)|NADH(DB00157)	CTTCTCTGCAGACCAGGAGAC	0.348000													23	80					1.2476e-16	2.0512e-16	0.706142	1	0
MARCH1	55016	broad.mit.edu	37	4	164534510	164534510	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:164534510G>T	ENST00000503008.1	-	5	1174	c.198C>A	c.(196-198)agC>agA	p.S66R	MARCH1_ENST00000274056.7_Missense_Mutation_p.S66R|MARCH1_ENST00000339875.5_Missense_Mutation_p.S49R|MARCH1_ENST00000514618.1_Missense_Mutation_p.S66R	NM_001166373.1	NP_001159845.1	Q8TCQ1	MARH1_HUMAN	membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase	66	Responsible for low stability (By similarity).				antigen processing and presentation of peptide antigen via MHC class II|immune response	cytoplasmic vesicle membrane|early endosome membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|plasma membrane	MHC protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(20)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	36	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				ACCTTGACTGGCTCCTGGGAG	0.413000													30	59					6.68952e-21	1.17224e-20	0.864702	1	0
KIF4B	285643	broad.mit.edu	37	5	154396718	154396718	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:154396718G>T	ENST00000435029.4	+	1	3459	c.3299G>T	c.(3298-3300)gGg>gTg	p.G1100V		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1100	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			AAGCAGTGTGGGTGCAGGAAG	0.527000													9	51					0.0581538	0.0603116	0.335167	1	0
DIAPH2	1730	broad.mit.edu	37	X	96203955	96203955	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:96203955C>T	ENST00000324765.8	+	15	1878	c.1531C>T	c.(1531-1533)Cga>Tga	p.R511*	DIAPH2_ENST00000355827.4_Nonsense_Mutation_p.R511*|DIAPH2_ENST00000373049.4_Nonsense_Mutation_p.R511*|DIAPH2_ENST00000373061.3_Nonsense_Mutation_p.R511*|DIAPH2_ENST00000373054.4_Nonsense_Mutation_p.R507*			O60879	DIAP2_HUMAN	diaphanous-related formin 2	511					cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding	p.R511R(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						ATTCACAGCTCGACAGGAAGC	0.348000													3	13					0	0	0.115264	0	0
KIF1B	23095	broad.mit.edu	37	1	10383941	10383941	+	Splice_Site	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:10383941G>T	ENST00000377086.1	+	25	2560		c.e25-1		KIF1B_ENST00000377081.1_Splice_Site|KIF1B_ENST00000263934.6_Splice_Site			O60333	KIF1B_HUMAN	kinesin family member 1B						anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TTTCTATTCAGGTGCAGTTTC	0.433000													13	64					3.51602e-12	5.2134e-12	0.575678	1	0
OR6F1	343169	broad.mit.edu	37	1	247875769	247875769	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:247875769A>G	ENST00000302084.2	-	1	336	c.289T>C	c.(289-291)Tgt>Cgt	p.C97R	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGCAAAAGACAGCTTGTAAAT	0.488000													20	56					0	0	0.681144	0	0
CHDC2	286464	broad.mit.edu	37	X	36103528	36103528	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:36103528G>T	ENST00000378660.1	+	5	702	c.514G>T	c.(514-516)Gtg>Ttg	p.V172L	CHDC2_ENST00000313548.4_Missense_Mutation_p.V172L					calponin homology domain containing 2																		CATTTATGATGTGCTGCTCCA	0.358000													9	79					2.68362e-12	4.01108e-12	0.411799	1	0
PSG1	5669	broad.mit.edu	37	19	43375970	43375970	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:43375970G>T	ENST00000244296.2	-	3	795	c.658C>A	c.(658-660)Cgg>Agg	p.R220R	PSG1_ENST00000312439.6_Silent_p.R220R|PSG1_ENST00000436291.2_Silent_p.R220R|PSG1_ENST00000595356.1_Silent_p.R220R|PSG1_ENST00000403380.3_Intron|PSG1_ENST00000595124.1_Intron	NM_006905.2	NP_008836.2			pregnancy specific beta-1-glycoprotein 1											breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	30		Prostate(69;0.00682)				ACTGGGTTCCGTATTTCACAT	0.517000													57	295					1.63007e-36	3.10994e-36	0.870114	1	0
MAST2	23139	broad.mit.edu	37	1	46476544	46476544	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:46476544G>T	ENST00000361297.2	+	10	1404	c.1121G>T	c.(1120-1122)cGg>cTg	p.R374L	MAST2_ENST00000372008.1_Missense_Mutation_p.R259L|MAST2_ENST00000372009.2_Intron	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	374					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GATAAATCTCGGAGTGGCCTC	0.463000													13	34					0.000308642	0.000345062	0.479597	1	0
HOXA13	3209	broad.mit.edu	37	7	27238953	27238953	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:27238953G>A	ENST00000222753.4	-	1	772	c.744C>T	c.(742-744)ggC>ggT	p.G248G	HOTTIP_ENST00000421733.1_RNA	NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	248					skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						TATCCAGGTAGCCAGGCATGG	0.677000			T	NUP98	AML								7	38					0	0	0.307466	0	0
PAX1	5075	broad.mit.edu	37	20	21687575	21687575	+	Silent	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:21687575C>G	ENST00000398485.2	+	2	840	c.786C>G	c.(784-786)ccC>ccG	p.P262P	PAX1_ENST00000444366.2_Silent_p.P238P|PAX1_ENST00000460221.1_3'UTR	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	262					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						CCGTGTCGCCCACGGGCGCCA	0.697000													7	26					0	0	0.248553	0	0
SEPT5	5413	broad.mit.edu	37	22	19707724	19707724	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:19707724A>T	ENST00000438754.2	+	4	632	c.352A>T	c.(352-354)Acg>Tcg	p.T118S	SEPT5_ENST00000406395.1_Missense_Mutation_p.T109S|SEPT5_ENST00000455784.2_Missense_Mutation_p.T109S|SEPT5_ENST00000383045.3_Missense_Mutation_p.T118S	NM_001009939.2	NP_001009939.1	Q99719	SEPT5_HUMAN	septin 5	109					cell cycle|cytokinesis|regulation of exocytosis|synaptic vesicle targeting	plasma membrane|septin complex|synaptic vesicle	GTP binding|GTPase activity|protein binding|structural molecule activity			lung(1)|upper_aerodigestive_tract(1)	2	Colorectal(54;0.0993)					CATCGTGGACACGCCGGGATT	0.597000													6	26					0	0	0.278610	0	0
TLR4	7099	broad.mit.edu	37	9	120476267	120476267	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:120476267C>A	ENST00000355622.6	+	3	1962	c.1861C>A	c.(1861-1863)Ctg>Atg	p.L621M	TLR4_ENST00000394487.4_Missense_Mutation_p.L581M|TLR4_ENST00000472304.1_3'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	621	LRRCT.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						CATGCCTGTGCTGAGTTTGAA	0.463000													8	14					7.48243e-07	9.31554e-07	0.335167	1	0
CRYBB3	1417	broad.mit.edu	37	22	25601330	25601330	+	Splice_Site	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:25601330G>A	ENST00000215855.2	+	5	550		c.e5+1		CRYBB3_ENST00000404334.1_Intron	NM_004076.3	NP_004067.1	P26998	CRBB3_HUMAN	crystallin, beta B3						visual perception		protein binding|structural constituent of eye lens			large_intestine(2)|lung(2)|prostate(1)	5						TCAACGGGACGTAAGGGACCC	0.532000													3	22					0	0	0.115264	0	0
PTPRB	5787	broad.mit.edu	37	12	71002973	71002973	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:71002973C>A	ENST00000334414.6	-	4	899	c.855G>T	c.(853-855)ttG>ttT	p.L285F	PTPRB_ENST00000538708.1_Missense_Mutation_p.L67F|PTPRB_ENST00000550358.1_Missense_Mutation_p.L285F|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000261266.5_Missense_Mutation_p.L67F|PTPRB_ENST00000451516.2_Missense_Mutation_p.L67F|PTPRB_ENST00000550857.1_Missense_Mutation_p.L67F|PTPRB_ENST00000551525.1_Missense_Mutation_p.L284F	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	67	Fibronectin type-III 3.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGGTAGGGCACAACGCGGCCC	0.478000													13	37					3.45872e-05	4.06181e-05	0.500413	1	0
ATP5G2	517	broad.mit.edu	37	12	54062982	54062982	+	Silent	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:54062982A>C	ENST00000338662.5	-	4	1514	c.309T>G	c.(307-309)tcT>tcG	p.S103S	ATP5G2_ENST00000394349.3_Silent_p.S144S|ATP5G2_ENST00000602871.1_Silent_p.S87S|ATP5G2_ENST00000550241.1_5'UTR|ATP5G2_ENST00000549164.1_Silent_p.S87S	NM_001002031.2	NP_001002031.1	Q06055	AT5G2_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)	87					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport	integral to membrane|mitochondrial proton-transporting ATP synthase complex|proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transmembrane transporter activity|lipid binding			kidney(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6						TCCCAGCCCCAGAACCAGCCA	0.527000													25	67					0	0	0.779181	0	0
KIAA1549	57670	broad.mit.edu	37	7	138554431	138554431	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:138554431C>A	ENST00000440172.1	-	14	4676	c.4628G>T	c.(4627-4629)gGg>gTg	p.G1543V	KIAA1549_ENST00000422774.1_Missense_Mutation_p.G1543V|KIAA1549_ENST00000242365.4_Missense_Mutation_p.G1493V	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1543						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CTCGTAGTGCCCGCGGCGCTT	0.617000			O	BRAF	pilocytic astrocytoma								11	25					0.000219431	0.000247802	0.457914	1	0
DACH2	117154	broad.mit.edu	37	X	85403694	85403694	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:85403694C>A	ENST00000373131.1	+	1	233	c.70C>A	c.(70-72)Cgg>Agg	p.R24R	DACH2_ENST00000373125.4_Silent_p.R24R	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						GGGCTTATTCCGGGCCGAACC	0.582000													3	6					0.150653	0.153678	0.150653	1	0
CXorf40A	91966	broad.mit.edu	37	X	148628335	148628335	+	Missense_Mutation	SNP	G	G	T	rs141148310		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:148628335G>T	ENST00000441248.1	+	4	1891	c.304G>T	c.(304-306)Gat>Tat	p.D102Y	CXorf40A_ENST00000428236.1_Missense_Mutation_p.D40Y|CXorf40A_ENST00000422892.2_Missense_Mutation_p.D102Y|CXorf40A_ENST00000423540.2_Missense_Mutation_p.D102Y|CXorf40A_ENST00000434353.2_Missense_Mutation_p.D102Y|CXorf40A_ENST00000393985.3_Missense_Mutation_p.D102Y|CXorf40A_ENST00000514208.1_Missense_Mutation_p.D102Y|CXorf40A_ENST00000359293.5_Missense_Mutation_p.D102Y|CXorf40A_ENST00000423421.1_Missense_Mutation_p.D102Y|CXorf40A_ENST00000450602.2_Missense_Mutation_p.D102Y			Q8TE69	CX04A_HUMAN	chromosome X open reading frame 40A	102							protein binding			breast(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CTTAACTCCCGATGAGGTTGT	0.468000													7	39					0.000673444	0.000741054	0.361761	1	0
ZNF804A	91752	broad.mit.edu	37	2	185801290	185801290	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:185801290G>T	ENST00000302277.6	+	4	1761	c.1167G>T	c.(1165-1167)gaG>gaT	p.E389D		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	389						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						CCACAACTGAGGTTGAAAATA	0.368000													22	36					7.92952e-12	1.15734e-11	0.667858	1	0
F5	2153	broad.mit.edu	37	1	169511332	169511332	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:169511332G>A	ENST00000367796.3	-	13	3212	c.3011C>T	c.(3010-3012)cCa>cTa	p.P1004L	F5_ENST00000367797.3_Missense_Mutation_p.P999L			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	999	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	AGGAAACTTTGGGTGGCCACT	0.463000													42	131					0	0	0.870114	0	0
RYR3	6263	broad.mit.edu	37	15	33938652	33938652	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:33938652G>A	ENST00000389232.4	+	29	3936	c.3866G>A	c.(3865-3867)cGc>cAc	p.R1289H	RYR3_ENST00000415757.3_Missense_Mutation_p.R1289H	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	1289	4 X approximate repeats.|B30.2/SPRY 3.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		ATCTATTGCCGCTTGAGCATG	0.537000													22	157					0	0	0.706142	0	0
CTNNA3	29119	broad.mit.edu	37	10	68139071	68139071	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:68139071G>T	ENST00000433211.1	-	12	1745	c.1571C>A	c.(1570-1572)gCc>gAc	p.A524D	CTNNA3_ENST00000373744.4_Missense_Mutation_p.A524D	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	524					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						GTCTCTTAAGGCTATGATACA	0.423000													12	48					1.99824e-07	2.56196e-07	0.520397	1	0
SLITRK6	84189	broad.mit.edu	37	13	86369115	86369115	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:86369115G>T	ENST00000400286.2	-	2	2127	c.1529C>A	c.(1528-1530)aCc>aAc	p.T510N		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	510						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		GTCAATCTGGGTTAGCAAATC	0.408000													12	62					1.05317e-09	1.43591e-09	0.457914	1	0
KEL	3792	broad.mit.edu	37	7	142643378	142643378	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:142643378G>A	ENST00000355265.2	-	11	1704	c.1230C>T	c.(1228-1230)tgC>tgT	p.C410C	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	410					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCTCCTCCACGCACTTCATCC	0.567000													10	16					0	0	0.361761	0	0
SUCLA2	8803	broad.mit.edu	37	13	48528647	48528647	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:48528647T>C	ENST00000378654.3	-	7	904	c.848A>G	c.(847-849)tAt>tGt	p.Y283C	SUCLA2_ENST00000543413.1_Missense_Mutation_p.Y225C|SUCLA2_ENST00000544100.1_Missense_Mutation_p.Y149C|SUCLA2_ENST00000534875.1_Missense_Mutation_p.Y225C	NM_003850.2	NP_003841.1	Q9P2R7	SUCB1_HUMAN	succinate-CoA ligase, ADP-forming, beta subunit	283	ATP-grasp.				succinyl-CoA pathway|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|metal ion binding|protein binding|succinate-CoA ligase (ADP-forming) activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(4)	15		all_cancers(8;1.13e-24)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|Lung NSC(96;0.000226)|all_hematologic(8;0.000885)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;2.1e-06)	Succinic acid(DB00139)	CTTTTGGCGATAGGCTGAATT	0.378000													21	41					0	0	0.639603	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858029	9858029	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:9858029C>T	ENST00000396573.2	-	14	3681	c.3372G>A	c.(3370-3372)aaG>aaA	p.K1124K	GRIN2A_ENST00000396575.2_Silent_p.K1124K|GRIN2A_ENST00000562109.1_Silent_p.K1124K|GRIN2A_ENST00000404927.2_Silent_p.K1124K|GRIN2A_ENST00000330684.3_Silent_p.K1124K|GRIN2A_ENST00000535259.1_Silent_p.K967K	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1124					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AACCAGGCTCCTTCTCACCAT	0.512000													34	84					0	0	0.870114	0	0
COBL	23242	broad.mit.edu	37	7	51096453	51096453	+	Silent	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:51096453C>G	ENST00000395542.2	-	12	2770	c.2586G>C	c.(2584-2586)ctG>ctC	p.L862L	COBL_ENST00000265136.7_Silent_p.L780L			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	780										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					AGGGTCGGCCCAGGTGTTTTT	0.577000													18	28					0	0	0.608945	0	0
MURC	347273	broad.mit.edu	37	9	103340822	103340822	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:103340822G>T	ENST00000307584.5	+	1	462	c.397G>T	c.(397-399)Gta>Tta	p.V133L		NM_001018116.1	NP_001018126.1	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	133					cell differentiation|muscle organ development|transcription, DNA-dependent					endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)	16		Acute lymphoblastic leukemia(62;0.0461)				ATTCCGCGTGGTAATATTCCA	0.378000													7	47					7.48243e-07	9.31554e-07	0.335167	1	0
TTN	7273	broad.mit.edu	37	2	179443955	179443955	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:179443955G>A	ENST00000589042.1	-	320	68026	c.67802C>T	c.(67801-67803)tCa>tTa	p.S22601L	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S13661L|RP11-171I2.2_ENST00000603521.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S13728L|TTN_ENST00000591111.1_Missense_Mutation_p.S20960L|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.S20033L|TTN_ENST00000460472.2_Missense_Mutation_p.S13536L|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20960	Fibronectin type-III 64.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACCGCAGATGACTCAACACT	0.448000													32	133					0	0	0.819951	0	0
BCORL1	63035	broad.mit.edu	37	X	129149565	129149565	+	Silent	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:129149565T>A	ENST00000540052.1	+	3	2861	c.2817T>A	c.(2815-2817)ccT>ccA	p.P939P	BCORL1_ENST00000303743.5_Silent_p.P939P|BCORL1_ENST00000359304.2_Silent_p.P939P|BCORL1_ENST00000218147.7_Silent_p.P939P	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	939					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CTGTTCAGCCTAGCGGTGGGG	0.562000													5	79					0	0	0.184627	0	0
RTDR1	27156	broad.mit.edu	37	22	23404056	23404056	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:23404056T>A	ENST00000216036.4	-	6	917	c.721A>T	c.(721-723)Aaa>Taa	p.K241*		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	241							binding			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		ACTGGGTCTTTCAGCAGATGG	0.587000													16	45					0	0	0.592651	0	0
RSPH1	89765	broad.mit.edu	37	21	43905839	43905839	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr21:43905839C>A	ENST00000291536.3	-	5	608	c.441G>T	c.(439-441)gaG>gaT	p.E147D	RSPH1_ENST00000398352.3_Missense_Mutation_p.E109D	NM_080860.2	NP_543136.1	Q8WYR4	RSPH1_HUMAN	radial spoke head 1 homolog (Chlamydomonas)	147					meiosis	cytosol|nucleus				large_intestine(7)|lung(2)|ovary(1)|prostate(1)|stomach(1)	12						CGGCCGTGCCCTCCTGCTGTC	0.507000													29	48					3.76114e-14	5.87284e-14	0.796494	1	0
STXBP5L	9515	broad.mit.edu	37	3	120998722	120998722	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:120998722G>T	ENST00000273666.6	+	19	2300	c.2029G>T	c.(2029-2031)Ggg>Tgg	p.G677W	STXBP5L_ENST00000472879.1_Missense_Mutation_p.G677W|STXBP5L_ENST00000497029.1_Missense_Mutation_p.G677W|STXBP5L_ENST00000471454.1_Missense_Mutation_p.G677W|STXBP5L_ENST00000492541.1_Missense_Mutation_p.G677W	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	677					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		GTTAAGCATGGGGACCATTGA	0.398000													29	49					6.29468e-14	9.80147e-14	0.804634	1	0
CDH18	1016	broad.mit.edu	37	5	19571711	19571711	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:19571711A>T	ENST00000507958.1	-	10	2220	c.1230T>A	c.(1228-1230)ccT>ccA	p.P410P	CDH18_ENST00000502796.1_Silent_p.P410P|CDH18_ENST00000506372.1_Silent_p.P410P|CDH18_ENST00000382275.1_Silent_p.P410P|CDH18_ENST00000274170.4_Silent_p.P410P|CDH18_ENST00000511273.1_Silent_p.P410P			Q13634	CAD18_HUMAN	cadherin 18, type 2	410	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					TAGTACTGTCAGGATCTTGTG	0.383000													34	80					0	0	0.819951	0	0
MAP7D3	79649	broad.mit.edu	37	X	135314150	135314150	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:135314150G>T	ENST00000316077.9	-	8	1186	c.966C>A	c.(964-966)tcC>tcA	p.S322S	MAP7D3_ENST00000370663.5_Silent_p.S304S|MAP7D3_ENST00000370661.1_Silent_p.S287S	NM_024597.3	NP_078873.2	Q8IWC1	MA7D3_HUMAN	MAP7 domain containing 3	322						cytoplasm|spindle				central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(2)|prostate(1)|skin(1)	44	Acute lymphoblastic leukemia(192;0.000127)					CTGCCTTGGGGGACGCTTCCA	0.567000													28	289					1.90571e-15	3.03502e-15	0.796494	1	0
NLRP10	338322	broad.mit.edu	37	11	7982583	7982583	+	Silent	SNP	G	G	T	rs138681119	byFrequency	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:7982583G>T	ENST00000328600.2	-	2	737	c.576C>A	c.(574-576)acC>acA	p.T192T		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	192	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		ACAGAGTACCGGTGGCCCAGT	0.532000													7	43					6.42651e-13	9.86929e-13	0.387290	1	0
CRKL	1399	broad.mit.edu	37	22	21288246	21288246	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:21288246G>A	ENST00000354336.3	+	2	1000	c.491G>A	c.(490-492)cGg>cAg	p.R164Q		NM_005207.3	NP_005198.1	P46109	CRKL_HUMAN	v-crk avian sarcoma virus CT10 oncogene homolog-like	164	SH3 1.				JNK cascade|Ras protein signal transduction	cytosol	protein tyrosine kinase activity|SH3/SH2 adaptor activity|signal transducer activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)	14	all_cancers(11;1.16e-25)|all_epithelial(7;3.37e-24)|Lung NSC(8;7.25e-16)|all_lung(8;1.37e-14)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.176)			TGGAGTGCCCGGAACAAGGAT	0.478000													3	78					0	0	0.150653	0	0
TET2	54790	broad.mit.edu	37	4	106156190	106156190	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:106156190G>T	ENST00000513237.1	+	3	1951	c.1154G>T	c.(1153-1155)gGt>gTt	p.G385V	TET2_ENST00000413648.2_Missense_Mutation_p.G364V|TET2_ENST00000394764.1_Missense_Mutation_p.G364V|TET2_ENST00000545826.1_Missense_Mutation_p.G364V|TET2_ENST00000305737.2_Missense_Mutation_p.G364V|TET2_ENST00000380013.4_Missense_Mutation_p.G364V|TET2_ENST00000540549.1_Missense_Mutation_p.G364V			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	364					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.G364fs*8(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		CAAGCTCCTGGTGGCAGCTCT	0.438000			"""Mis N, F"""		MDS								9	28					1.58986e-06	1.96189e-06	0.361761	1	0
RAB19	401409	broad.mit.edu	37	7	140125719	140125719	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:140125719G>T	ENST00000275874.5	+	5	762	c.564G>T	c.(562-564)ctG>ctT	p.L188L	RAB19_ENST00000537763.1_Silent_p.L141L|RAB19_ENST00000356407.3_Silent_p.L141L			A4D1S5	RAB19_HUMAN	RAB19, member RAS oncogene family	141					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			breast(3)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)	9	Melanoma(164;0.0142)					GGCACGTCCTGTTCGAGGATG	0.458000													21	76					5.35356e-11	7.65381e-11	0.639603	1	0
F2RL2	2151	broad.mit.edu	37	5	75913449	75913449	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:75913449C>G	ENST00000296641.4	-	2	1286	c.1083G>C	c.(1081-1083)atG>atC	p.M361I	IQGAP2_ENST00000502745.1_Intron|IQGAP2_ENST00000396234.3_Intron|F2RL2_ENST00000504899.1_Missense_Mutation_p.M339I|IQGAP2_ENST00000379730.3_Intron|IQGAP2_ENST00000274364.6_Intron	NM_004101.3	NP_004092.1	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	361					platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(3)	32		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		TGGTTTTTGACATGAGAAAAT	0.358000													11	37					0	0	0.411799	0	0
LRP1B	53353	broad.mit.edu	37	2	141214133	141214133	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:141214133C>A	ENST00000389484.3	-	62	10825	c.9854G>T	c.(9853-9855)aGt>aTt	p.S3285I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3285					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCACAAATGACTGCAACCACC	0.378000										TSP Lung(27;0.18)			41	53					9.57592e-29	1.7725e-28	0.870114	1	0
ZNF462	58499	broad.mit.edu	37	9	109689688	109689688	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:109689688C>T	ENST00000277225.5	+	3	3784	c.3495C>T	c.(3493-3495)ggC>ggT	p.G1165G	ZNF462_ENST00000441147.2_Silent_p.G10G|ZNF462_ENST00000457913.1_Silent_p.G1165G			Q96JM2	ZN462_HUMAN	zinc finger protein 462	1165					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|autonomic_ganglia(2)|breast(5)|central_nervous_system(4)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(20)|lung(32)|ovary(5)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	119						GGCCCCAAGGCTCCCCCCGGC	0.547000													15	72					0	0	0.520397	0	0
CR2	1380	broad.mit.edu	37	1	207649630	207649630	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:207649630G>T	ENST00000367057.3	+	15	2957	c.2768G>T	c.(2767-2769)gGt>gTt	p.G923V	CR2_ENST00000458541.2_Missense_Mutation_p.G837V|CR2_ENST00000367059.3_Intron|CR2_ENST00000367058.3_Missense_Mutation_p.G864V	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	864	Sushi 15.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						AACCATACTGGTGGAAACATA	0.498000													30	82					1.43246e-33	2.68707e-33	0.834066	1	0
THADA	63892	broad.mit.edu	37	2	43547623	43547623	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:43547623G>A	ENST00000405006.4	-	31	4751	c.4400C>T	c.(4399-4401)aCt>aTt	p.T1467I	THADA_ENST00000415080.2_Missense_Mutation_p.T1148I|THADA_ENST00000405975.2_Missense_Mutation_p.T1467I|THADA_ENST00000330266.7_Intron	NM_001083953.1|NM_001271643.1	NP_001077422.1|NP_001258572.1	Q6YHU6	THADA_HUMAN	thyroid adenoma associated	1467							binding			breast(1)|endometrium(9)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	66		Acute lymphoblastic leukemia(82;0.00361)|all_hematologic(82;0.00837)				GAGGCAGCAAGTCAATAGGAA	0.378000													35	73					0	0	0.870114	0	0
DPP6	1804	broad.mit.edu	37	7	154143392	154143392	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:154143392T>A	ENST00000404039.1	+	2	732	c.145T>A	c.(145-147)Tcg>Acg	p.S49T	DPP6_ENST00000332007.3_Missense_Mutation_p.S51T|DPP6_ENST00000406326.1_Missense_Mutation_p.S113T|DPP6_ENST00000377770.3_Missense_Mutation_p.S113T|DPP6_ENST00000496611.1_3'UTR|DPP6_ENST00000427557.1_Missense_Mutation_p.S51T	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	113					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GATCGTCACCTCGGTCATACT	0.433000													24	87					0	0	0.717897	0	0
VCAM1	7412	broad.mit.edu	37	1	101198174	101198174	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:101198174G>T	ENST00000294728.2	+	7	1827	c.1726G>T	c.(1726-1728)Gtt>Ttt	p.V576F	VCAM1_ENST00000370115.1_Missense_Mutation_p.V377F|VCAM1_ENST00000347652.2_Missense_Mutation_p.V484F|VCAM1_ENST00000370119.4_Missense_Mutation_p.V514F	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	576	Ig-like C2-type 6.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	AGATTCTGGGGTTTATTTATG	0.428000													15	40					2.32078e-09	3.12607e-09	0.479597	1	0
MDH2	4191	broad.mit.edu	37	7	75692874	75692874	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:75692874C>T	ENST00000315758.5	+	6	691	c.597C>T	c.(595-597)ggC>ggT	p.G199G	MDH2_ENST00000432020.2_Silent_p.G157G|MDH2_ENST00000443006.1_Silent_p.G92G	NM_005918.2	NP_005909.2	P40926	MDHM_HUMAN	malate dehydrogenase 2, NAD (mitochondrial)	199					gluconeogenesis|malate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus|plasma membrane	binding|L-malate dehydrogenase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(2)	14					NADH(DB00157)	TCATTGGTGGCCATGCTGGGA	0.517000													22	74					0	0	0.769981	0	0
MXRA5	25878	broad.mit.edu	37	X	3240763	3240763	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:3240763G>T	ENST00000217939.6	-	5	3117	c.2963C>A	c.(2962-2964)cCa>cAa	p.P988Q		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	988						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ATCCTCATCTGGTTGTGACTT	0.468000													18	47					1.33834e-09	1.81585e-09	0.557998	1	0
AQP10	89872	broad.mit.edu	37	1	154293696	154293696	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:154293696G>T	ENST00000484864.1	+	1	101	c.65G>T	c.(64-66)cGg>cTg	p.R22L	AQP10_ENST00000355197.4_3'UTR|AQP10_ENST00000324978.3_Missense_Mutation_p.R22L			Q96PS8	AQP10_HUMAN	aquaporin 10	22					response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(14)|stomach(2)|upper_aerodigestive_tract(1)	23	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTCCTGGCCCGGCAGTGCCTG	0.567000													35	83					2.13384e-23	3.84779e-23	0.870114	1	0
BEND2	139105	broad.mit.edu	37	X	18192332	18192332	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:18192332G>A	ENST00000380033.4	-	12	1931	c.1799C>T	c.(1798-1800)gCa>gTa	p.A600V	BEND2_ENST00000380030.3_Missense_Mutation_p.A509V	NM_153346.4	NP_699177.2	Q8NDZ0	BEND2_HUMAN	BEN domain containing 2	600										NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(11)|liver(1)|lung(21)|ovary(3)|prostate(1)	49						ATCTGCAGATGCCGATGCAAC	0.403000													8	88					0	0	0.361761	0	0
VPS13D	55187	broad.mit.edu	37	1	12414217	12414217	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:12414217G>A	ENST00000358136.3	+	47	9748	c.9618G>A	c.(9616-9618)acG>acA	p.T3206T	VPS13D_ENST00000356315.4_Silent_p.T3181T	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	3205					protein localization			p.T3206T(1)		NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TTAATGGGACGCTGAAACCTG	0.433000													6	64					0	0	0.217242	0	0
PRKACA	5566	broad.mit.edu	37	19	14208238	14208238	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:14208238C>A	ENST00000308677.4	-	8	896	c.700G>T	c.(700-702)Gct>Tct	p.A234S	PRKACA_ENST00000590853.1_Intron|PRKACA_ENST00000589994.1_Missense_Mutation_p.A226S|PRKACA_ENST00000350356.3_5'UTR	NM_002730.3	NP_002721.1	P17612	KAPCA_HUMAN	protein kinase, cAMP-dependent, catalytic, alpha	234	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|gluconeogenesis|intracellular protein kinase cascade|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|regulation of insulin secretion|transmembrane transport|triglyceride catabolic process|water transport	cAMP-dependent protein kinase complex|centrosome|cytosol|nucleoplasm|plasma membrane	ATP binding|cAMP-dependent protein kinase activity|cAMP-dependent protein kinase inhibitor activity|protein kinase binding			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)	16						GGGTAGCCAGCGGCCATTTCA	0.607000													13	33					1.15088e-07	1.48235e-07	0.500413	1	0
SYNE2	23224	broad.mit.edu	37	14	64460674	64460674	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:64460674G>T	ENST00000358025.3	+	22	2998	c.2768G>T	c.(2767-2769)tGt>tTt	p.C923F	SYNE2_ENST00000554584.1_Missense_Mutation_p.C923F|SYNE2_ENST00000344113.4_Missense_Mutation_p.C923F|SYNE2_ENST00000357395.3_5'UTR	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	923					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGAGATGTCTGTGCCAAATGG	0.383000													18	65					9.57634e-11	1.35523e-10	0.654019	1	0
BGN	633	broad.mit.edu	37	X	152773762	152773762	+	Silent	SNP	C	C	A	rs141929620	byFrequency	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:152773762C>A	ENST00000331595.4	+	8	1152	c.966C>A	c.(964-966)ccC>ccA	p.P322P	BGN_ENST00000370204.1_Silent_p.P261P|BGN_ENST00000480756.1_3'UTR	NM_001711.4	NP_001702.1	P21810	PGS1_HUMAN	biglycan	322						proteinaceous extracellular matrix|transport vesicle	extracellular matrix structural constituent			breast(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ACTTCTGTCCCATGGGCTTCG	0.612000													25	212					6.38683e-12	9.42015e-12	0.729181	1	0
IDS	3423	broad.mit.edu	37	X	148585762	148585762	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:148585762C>A	ENST00000340855.6	-	2	374	c.165G>T	c.(163-165)ggG>ggT	p.G55G	IDS_ENST00000541269.1_Intron|IDS_ENST00000428056.2_Silent_p.G55G|IDS_ENST00000370441.4_Silent_p.G55G|AF011889.5_ENST00000422081.1_RNA|IDS_ENST00000370443.4_Silent_p.G55G	NM_000202.5|NM_001166550.1	NP_000193.1|NP_001160022.1	P22304	IDS_HUMAN	iduronate 2-sulfatase	55						lysosome	iduronate-2-sulfatase activity|metal ion binding			NS(1)|breast(3)|endometrium(5)|large_intestine(2)|lung(8)|prostate(1)	20	Acute lymphoblastic leukemia(192;6.56e-05)|Colorectal(9;0.0662)					CCAGCTTATCCCCATAACAGC	0.552000													7	28					0.00198382	0.00214498	0.248553	1	0
OR1D2	4991	broad.mit.edu	37	17	2995604	2995604	+	Silent	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:2995604G>C	ENST00000331459.1	-	1	686	c.687C>G	c.(685-687)ccC>ccG	p.P229P		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	229					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						TAGAGACTGAGGGTATTCTGA	0.473000													23	43					0	0	0.729181	0	0
PQLC3	130814	broad.mit.edu	37	2	11300801	11300801	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:11300801G>T	ENST00000295083.3	+	3	452	c.277G>T	c.(277-279)Gcc>Tcc	p.A93S	PQLC3_ENST00000402361.1_Missense_Mutation_p.A93S|PQLC3_ENST00000476787.1_3'UTR|PQLC3_ENST00000441908.2_Missense_Mutation_p.A93S	NM_152391.3	NP_689604.1	Q8N755	PQLC3_HUMAN	PQ loop repeat containing 3	93						integral to membrane				kidney(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	6	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0978)|OV - Ovarian serous cystadenocarcinoma(76;0.132)		CGTGAAGCAGGCCACTCCTTA	0.502000													32	81					7.53189e-24	1.36699e-23	0.834066	1	0
KIF4B	285643	broad.mit.edu	37	5	154396717	154396717	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:154396717G>T	ENST00000435029.4	+	1	3458	c.3298G>T	c.(3298-3300)Ggg>Tgg	p.G1100W		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	1100	Globular (By similarity).|Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CAAGCAGTGTGGGTGCAGGAA	0.532000													9	51					0.0581538	0.0603116	0.335167	1	0
CD200	4345	broad.mit.edu	37	3	112064051	112064051	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:112064051C>A	ENST00000315711.8	+	3	394	c.337C>A	c.(337-339)Ctg>Atg	p.L113M	CD200_ENST00000473539.1_Missense_Mutation_p.L138M|CD200_ENST00000383681.3_Missense_Mutation_p.L39M	NM_005944.5	NP_005935.4	P41217	OX2G_HUMAN	CD200 molecule	113	Ig-like V-type.				regulation of immune response	integral to plasma membrane				endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				GAATATCACCCTGGAGGATGA	0.488000													24	43					3.1745e-13	4.90205e-13	0.729181	1	0
MRRF	92399	broad.mit.edu	37	9	125047485	125047485	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:125047485G>T	ENST00000344641.3	+	4	689	c.378G>T	c.(376-378)ggG>ggT	p.G126G	MRRF_ENST00000373730.3_Silent_p.G126G|MRRF_ENST00000373728.1_Silent_p.G126G|MRRF_ENST00000394315.3_Silent_p.G126G|MRRF_ENST00000546115.1_Silent_p.G126G|MRRF_ENST00000297908.3_Silent_p.G74G|MRRF_ENST00000373727.1_Silent_p.G126G|MRRF_ENST00000373729.1_Silent_p.G82G|MRRF_ENST00000373723.4_Silent_p.G126G	NM_138777.3	NP_620132.1	Q96E11	RRFM_HUMAN	mitochondrial ribosome recycling factor	126					ribosome disassembly|translation	mitochondrion	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	12						CTGCTGACGGGAAGCTTGCTT	0.433000													5	40					6.5536e-12	9.64069e-12	0.278610	1	0
STARD13	90627	broad.mit.edu	37	13	33704181	33704181	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:33704181C>A	ENST00000336934.5	-	5	749	c.633G>T	c.(631-633)caG>caT	p.Q211H	STARD13_ENST00000399365.3_Missense_Mutation_p.Q93H|STARD13_ENST00000255486.4_Missense_Mutation_p.Q203H	NM_001243476.1|NM_178006.3	NP_001230405.1|NP_821074.1	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain containing 13	211					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	40	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		ACTGGCCCGGCTGGCTGCGAC	0.632000													6	36					5.9392e-07	7.4607e-07	0.217242	1	0
SHCBP1	79801	broad.mit.edu	37	16	46633784	46633784	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:46633784C>G	ENST00000303383.3	-	9	1570	c.1304G>C	c.(1303-1305)gGc>gCc	p.G435A		NM_024745.4	NP_079021.3	Q8NEM2	SHCBP_HUMAN	SHC SH2-domain binding protein 1	435										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(37;0.00404)|all_epithelial(9;0.00527)|all_lung(18;0.0413)|Lung NSC(13;0.213)				AAATTTTATGCCTGAGATTTT	0.388000													8	36					0	0	0.307466	0	0
HCN1	348980	broad.mit.edu	37	5	45645616	45645616	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:45645616G>T	ENST00000303230.4	-	2	577	c.520C>A	c.(520-522)Cca>Aca	p.P174T		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	174						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						ATAATCCATGGTGTTGTTGTT	0.353000													13	74					1.37285e-15	2.19264e-15	0.500413	1	0
NANOGP1	404635	broad.mit.edu	37	12	8048154	8048154	+	RNA	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:8048154C>A	ENST00000607111.1	+	0	82																				kidney(1)|lung(4)|prostate(1)	6						AAACAACCCACTACTGCAGAG	0.468000													20	78					2.27525e-19	3.91344e-19	0.667858	1	0
OTOF	9381	broad.mit.edu	37	2	26700586	26700586	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:26700586A>T	ENST00000272371.2	-	19	2372	c.2246T>A	c.(2245-2247)aTc>aAc	p.I749N	OTOF_ENST00000402415.3_Missense_Mutation_p.I59N|OTOF_ENST00000339598.3_Missense_Mutation_p.I2N|OTOF_ENST00000403946.3_Missense_Mutation_p.I749N|OTOF_ENST00000338581.6_Missense_Mutation_p.I2N	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	749					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCCGTTTTGATCATCTCCTG	0.637000													12	29					0	0	0.479597	0	0
A1CF	29974	broad.mit.edu	37	10	52619638	52619638	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:52619638G>A	ENST00000282641.2	-	3	250	c.63C>T	c.(61-63)cgC>cgT	p.R21R	A1CF_ENST00000395495.1_Silent_p.R21R|A1CF_ENST00000373993.1_Silent_p.R21R|A1CF_ENST00000374001.1_Silent_p.R21R|A1CF_ENST00000373997.3_Silent_p.R21R|A1CF_ENST00000395489.2_5'UTR|A1CF_ENST00000373995.3_5'UTR	NM_138932.2	NP_620310.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	21					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						GGACCAGTGCGCGGAGGGCTG	0.483000													6	104					0	0	0.278610	0	0
UBXN11	91544	broad.mit.edu	37	1	26620716	26620716	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:26620716G>C	ENST00000374222.1	-	9	1003	c.539C>G	c.(538-540)gCc>gGc	p.A180G	UBXN11_ENST00000374217.2_Missense_Mutation_p.A147G|UBXN11_ENST00000535108.1_Missense_Mutation_p.A22G|UBXN11_ENST00000436301.2_Missense_Mutation_p.A105G|UBXN11_ENST00000357089.4_Missense_Mutation_p.A147G|UBXN11_ENST00000374221.3_Missense_Mutation_p.A180G|UBXN11_ENST00000374223.1_Intron|UBXN11_ENST00000314675.7_Intron			Q5T124	UBX11_HUMAN	UBX domain protein 11	180						cytoplasm|cytoskeleton				endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(3)	23						GAACTTCTTGGCTGTCATCCA	0.592000													3	92					0	0	0.184627	0	0
DDX53	168400	broad.mit.edu	37	X	23018308	23018308	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:23018308G>T	ENST00000327968.5	+	1	222	c.134G>T	c.(133-135)gGc>gTc	p.G45V	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	45						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						AGAGCAGCAGGCTCCCGTGAA	0.517000													11	45					1.02788e-11	1.48857e-11	0.520397	1	0
OR56A4	120793	broad.mit.edu	37	11	6023851	6023851	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:6023851G>C	ENST00000330728.4	-	1	573	c.528C>G	c.(526-528)gaC>gaG	p.D176E		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	124					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCACATAACGGTCATAGGCCA	0.507000													12	40					0	0	0.411799	0	0
CRB1	23418	broad.mit.edu	37	1	197396937	197396937	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:197396937G>A	ENST00000367397.1	+	3	1483	c.625G>A	c.(625-627)Gat>Aat	p.D209N	CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367400.3_Missense_Mutation_p.D828N|CRB1_ENST00000367399.2_Missense_Mutation_p.D716N|CRB1_ENST00000544212.1_Missense_Mutation_p.D309N|CRB1_ENST00000535699.1_Missense_Mutation_p.D759N			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	828	EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CGAAAAGGGAGATGTCATCTA	0.368000													18	37					0	0	0.608945	0	0
C5orf46	389336	broad.mit.edu	37	5	147286025	147286025	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:147286025G>T	ENST00000515291.1	-	1	76	c.40C>A	c.(40-42)Ctg>Atg	p.L14M	C5orf46_ENST00000318315.4_Missense_Mutation_p.L14M|C5orf46_ENST00000510432.1_5'UTR			Q6UWT4	CE046_HUMAN	chromosome 5 open reading frame 46	14						extracellular region				NS(1)|lung(1)|prostate(1)	3						AAGACAAGCAGTCCCAGGACA	0.463000													16	34					3.8784e-16	6.28414e-16	0.608945	1	0
FBN2	2201	broad.mit.edu	37	5	127624914	127624914	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:127624914A>C	ENST00000508053.1	-	58	7516	c.6542T>G	c.(6541-6543)aTt>aGt	p.I2181S	FBN2_ENST00000262464.4_Missense_Mutation_p.I2181S			P35556	FBN2_HUMAN	fibrillin 2	2181	EGF-like 36; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ATTTGAACAAATGCCTGGGCT	0.458000													20	56					0	0	0.667858	0	0
PPP1R26	9858	broad.mit.edu	37	9	138376996	138376996	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:138376996G>T	ENST00000356818.2	+	4	1189	c.640G>T	c.(640-642)Gtc>Ttc	p.V214F	PPP1R26_ENST00000605286.1_Missense_Mutation_p.V214F|PPP1R26_ENST00000605660.1_Missense_Mutation_p.V214F|PPP1R26_ENST00000604351.1_Missense_Mutation_p.V214F|PPP1R26_ENST00000401470.3_Missense_Mutation_p.V214F|PPP1R26_ENST00000602993.1_Intron	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	214						nucleolus	protein binding										CGCCTCCCCGGTCAGTGTGAG	0.582000													8	67					1.10513e-12	1.67872e-12	0.624587	1	0
CAMSAP1	157922	broad.mit.edu	37	9	138710463	138710463	+	Splice_Site	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:138710463C>A	ENST00000389532.4	-	13	4024		c.e13-1		CAMSAP1_ENST00000312405.6_Splice_Site|CAMSAP1_ENST00000483991.1_Splice_Site|CAMSAP1_ENST00000409386.3_Splice_Site	NM_015447.3	NP_056262.3	Q5T5Y3	CAMP1_HUMAN	calmodulin regulated spectrin-associated protein 1							cytoplasm|microtubule				breast(3)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(11)|lung(16)|ovary(3)|pancreas(1)|skin(1)	47				OV - Ovarian serous cystadenocarcinoma(145;1.4e-06)|Epithelial(140;1.11e-05)		AGCTTTGCGCCTGAGAGAAAC	0.652000													7	28					1.12685e-05	1.33455e-05	0.307466	1	0
PILRA	29992	broad.mit.edu	37	7	99972004	99972004	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:99972004A>T	ENST00000198536.2	+	2	614	c.402A>T	c.(400-402)tcA>tcT	p.S134S	PILRA_ENST00000453419.1_Silent_p.S134S|PILRA_ENST00000394000.2_Silent_p.S134S|PILRA_ENST00000350573.2_Silent_p.S134S|PILRA_ENST00000474013.1_3'UTR	NM_013439.2	NP_038467.2	Q9UKJ1	PILRA_HUMAN	paired immunoglobin-like type 2 receptor alpha	134	Ig-like V-type.				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	15	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CACGGAGCTCAGGGAGGCAGC	0.607000													31	93					0	0	0.812448	0	0
AHSG	197	broad.mit.edu	37	3	186335029	186335029	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:186335029C>T	ENST00000411641.2	+	4	682	c.463C>T	c.(463-465)Ctg>Ttg	p.L155L	AHSG_ENST00000273784.5_Silent_p.L156L			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	155	Cystatin fetuin-A-type 2.			PLLAPLNDTRVVHAAKAALAAFNAQNNGSNFQL -> MVGW QEGANHKNGAGRSQKQEMAEKMVPEVASG (in Ref. 12; AAF69649).	acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GCTGGCCCCGCTGAACGACAC	0.632000											OREG0015968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	50					0	0	0.760397	0	0
THBS2	7058	broad.mit.edu	37	6	169648752	169648752	+	Silent	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:169648752C>G	ENST00000366787.3	-	4	618	c.369G>C	c.(367-369)acG>acC	p.T123T		NM_003247.2	NP_003238.2	P35442	TSP2_HUMAN	thrombospondin 2	123	Heparin-binding (Potential).|TSP N-terminal.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			NS(3)|biliary_tract(1)|endometrium(8)|kidney(3)|large_intestine(23)|liver(1)|lung(56)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	111		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TGAGATCCAGCGTGTCCGCGG	0.652000													23	53					0	0	0.717897	0	0
AMMECR1	9949	broad.mit.edu	37	X	109459750	109459750	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:109459750C>A	ENST00000262844.5	-	3	862	c.695G>T	c.(694-696)tGg>tTg	p.W232L	AMMECR1_ENST00000372059.2_Missense_Mutation_p.W195L|AMMECR1_ENST00000372057.1_Missense_Mutation_p.W109L	NM_015365.2	NP_056180.1	Q9Y4X0	AMER1_HUMAN	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	232	AMMECR1.									large_intestine(1)|lung(4)|ovary(1)|stomach(1)	7						TCTTACCTCCCAGTCCAAATA	0.398000													12	75					4.36969e-10	6.0164e-10	0.435327	1	0
FAM160A2	84067	broad.mit.edu	37	11	6233027	6233027	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:6233027C>A	ENST00000265978.4	-	12	3028	c.2670G>T	c.(2668-2670)caG>caT	p.Q890H	FAM160A2_ENST00000529360.1_5'UTR|FAM160A2_ENST00000449352.2_Missense_Mutation_p.Q876H	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	876					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						ATTGTGCCGCCTGCCGGGCCC	0.622000													92	173					1.26781e-57	2.52209e-57	0.870114	1	0
NELL1	4745	broad.mit.edu	37	11	21581787	21581787	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:21581787C>A	ENST00000298925.5	+	18	2076	c.1923C>A	c.(1921-1923)tgC>tgA	p.C641*	NELL1_ENST00000529218.1_Intron|NELL1_ENST00000532434.1_Nonsense_Mutation_p.C566*|NELL1_ENST00000325319.5_Nonsense_Mutation_p.C556*|NELL1_ENST00000357134.5_Nonsense_Mutation_p.C613*			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	613	VWFC 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						ATTCTGCCTGCATCAACCTGG	0.522000													33	116					4.29476e-34	8.0834e-34	0.870114	1	0
RYR2	6262	broad.mit.edu	37	1	237778129	237778129	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:237778129C>A	ENST00000366574.2	+	37	6018	c.5701C>A	c.(5701-5703)Cca>Aca	p.P1901T	RYR2_ENST00000542537.1_Missense_Mutation_p.P1885T|RYR2_ENST00000360064.6_Missense_Mutation_p.P1899T	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1901	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.P1899T(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACTGCCAGAGCCAGTTAAATT	0.473000													15	25					1.87028e-06	2.29274e-06	0.608945	1	0
ABCA10	10349	broad.mit.edu	37	17	67150045	67150045	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:67150045T>C	ENST00000269081.4	-	33	4801	c.3892A>G	c.(3892-3894)Atg>Gtg	p.M1298V	ABCA10_ENST00000519732.1_5'UTR|ABCA10_ENST00000416101.2_3'UTR	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	1298	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					TGCTCTTTCATTGTAAGCTTG	0.478000													31	120					0	0	0.779181	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885420	88885420	+	Missense_Mutation	SNP	G	G	C	rs147092234		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:88885420G>C	ENST00000319675.3	-	1	876	c.780C>G	c.(778-780)agC>agG	p.S260R		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	260										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						CCTTCCACCCGCTGCCTTGAT	0.502000													17	80					0	0	0.608945	0	0
DYM	54808	broad.mit.edu	37	18	46808540	46808540	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:46808540T>A	ENST00000269445.6	-	10	1409	c.952A>T	c.(952-954)Agt>Tgt	p.S318C	DYM_ENST00000442713.2_Missense_Mutation_p.S128C	NM_017653.3	NP_060123.3	Q7RTS9	DYM_HUMAN	dymeclin	318						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						GGGAAAGGACTGCTATCTGGA	0.358000													20	39					0	0	0.681144	0	0
SMARCA1	6594	broad.mit.edu	37	X	128645819	128645819	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:128645819G>T	ENST00000371122.4	-	6	901	c.772C>A	c.(772-774)Ctc>Atc	p.L258I	SMARCA1_ENST00000478420.1_5'UTR|SMARCA1_ENST00000371123.1_Missense_Mutation_p.L258I|SMARCA1_ENST00000371121.3_Missense_Mutation_p.L258I	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	258	Helicase ATP-binding.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						ATGACACGGAGAGATGGGACC	0.388000													16	155					5.03518e-11	7.2171e-11	0.557998	1	0
ZP4	57829	broad.mit.edu	37	1	238048463	238048463	+	Splice_Site	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:238048463A>T	ENST00000366570.4	-	9	1470		c.e9+1		RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4						acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			GGAACATCCTACCGGTCCCCT	0.527000													13	55					0	0	0.479597	0	0
ADCK1	57143	broad.mit.edu	37	14	78325441	78325441	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:78325441G>A	ENST00000238561.5	+	4	341	c.242G>A	c.(241-243)cGt>cAt	p.R81H	ADCK1_ENST00000341211.5_Intron	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	88						extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		TCTGCCAGGCGTCTCTGTGAG	0.607000													6	159					0	0	0.278610	0	0
TTN	7273	broad.mit.edu	37	2	179542447	179542447	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:179542447C>A	ENST00000589042.1	-	146	34416	c.34192G>T	c.(34192-34194)Gtt>Ttt	p.V11398F	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.V11081F|TTN_ENST00000342992.6_Missense_Mutation_p.V10154F|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11081	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCGGGAGGAACTTCCTCTTCC	0.458000													28	53					1.17739e-12	1.77882e-12	0.693898	1	0
CLEC4F	165530	broad.mit.edu	37	2	71044180	71044180	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:71044180C>T	ENST00000272367.2	-	4	409	c.333G>A	c.(331-333)atG>atA	p.M111I	CLEC4F_ENST00000426626.1_Missense_Mutation_p.M111I	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	111					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TGGAATTCTCCATGTGGCCTT	0.502000													10	35					0	0	0.335167	0	0
GABBR1	2550	broad.mit.edu	37	6	29577145	29577145	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:29577145G>A	ENST00000377034.4	-	15	2055	c.1720C>T	c.(1720-1722)Cca>Tca	p.P574S	GABBR1_ENST00000376977.3_Intron|GABBR1_ENST00000377012.4_Missense_Mutation_p.P457S|GABBR1_ENST00000377016.4_Missense_Mutation_p.P512S|GABBR1_ENST00000355973.3_Missense_Mutation_p.P457S	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	574					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	TGGTCAGCTGGGGGGGACCCT	0.542000													19	39					0	0	0.667858	0	0
LBR	3930	broad.mit.edu	37	1	225598013	225598013	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:225598013C>A	ENST00000338179.2	-	10	1419	c.1294G>T	c.(1294-1296)Gtg>Ttg	p.V432L	LBR_ENST00000272163.4_Missense_Mutation_p.V432L	NM_194442.2	NP_919424.1	Q14739	LBR_HUMAN	lamin B receptor	432					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		AGAGCATCCACCACATAGAGA	0.453000													33	69					1.57351e-24	2.87449e-24	0.788014	1	0
MCF2	4168	broad.mit.edu	37	X	138670544	138670544	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:138670544C>A	ENST00000520602.1	-	24	2889	c.2604G>T	c.(2602-2604)ttG>ttT	p.L868F	MCF2_ENST00000370576.4_Missense_Mutation_p.L808F|MCF2_ENST00000370578.4_Missense_Mutation_p.L953F|MCF2_ENST00000536274.1_Missense_Mutation_p.L769F|MCF2_ENST00000370573.4_Missense_Mutation_p.L808F|MCF2_ENST00000414978.1_Missense_Mutation_p.L868F|MCF2_ENST00000519895.1_Missense_Mutation_p.L884F|MCF2_ENST00000338585.6_Missense_Mutation_p.L824F			P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	808					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			NS(2)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(15)|lung(34)|pancreas(1)|pleura(1)|prostate(1)	62	Acute lymphoblastic leukemia(192;0.000127)					GCTGCTTCAACAAAATATTTC	0.333000													15	15					1.01871e-10	1.43803e-10	0.575678	1	0
LOC101927079	101927079	broad.mit.edu	37	15	22332492	22332492	+	RNA	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:22332492A>C	ENST00000558896.1	+	0	299																											TATTTCTCTTATTACTATTTT	0.383000													5	93					0	0	0.184627	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20488784	20488784	+	RNA	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:20488784G>A	ENST00000555186.1	+	0	267					NR_038836.1																						TTTTGGGAGAGACCTCTCTCA	0.408000													6	73					0	0	0.278610	0	0
TOR1AIP1	26092	broad.mit.edu	37	1	179887219	179887219	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:179887219A>T	ENST00000435319.3	+	10	1788	c.1597A>T	c.(1597-1599)Aga>Tga	p.R533*	TOR1AIP1_ENST00000271583.3_Nonsense_Mutation_p.R549*	NM_001267578.1|NM_015602.3	NP_001254507.1|NP_056417.2	Q5JTV8	TOIP1_HUMAN	torsin A interacting protein 1	533						integral to membrane|nuclear inner membrane				breast(4)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	18						AGAAAAAGTAAGAGATTTTCT	0.423000													31	56					0	0	0.796494	0	0
UBE2A	7319	broad.mit.edu	37	X	118708880	118708880	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:118708880C>T	ENST00000371558.2	+	2	235	c.61C>T	c.(61-63)Cca>Tca	p.P21S	UBE2A_ENST00000346330.3_Missense_Mutation_p.P21S|UBE2A_ENST00000469205.1_3'UTR	NM_003336.2|NM_181762.1	NP_003327.2|NP_861427.1	P49459	UBE2A_HUMAN	ubiquitin-conjugating enzyme E2A	21					histone H2A ubiquitination|positive regulation of cell proliferation|postreplication repair|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|response to UV|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity			haematopoietic_and_lymphoid_tissue(1)|lung(7)	8						GGAGGATCCTCCAGCCGGAGT	0.682000								Rad6 pathway					11	105					0	0	0.435327	0	0
ATP6V0C	527	broad.mit.edu	37	16	2569624	2569624	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:2569624G>T	ENST00000330398.4	+	3	580	c.346G>T	c.(346-348)Gct>Tct	p.A116S	ATP6V0C_ENST00000568562.1_3'UTR|ATP6V0C_ENST00000564973.1_Missense_Mutation_p.A73S|RP11-20I23.1_ENST00000564543.1_3'UTR|ATP6C_ENST00000569317.1_Intron|ATP6V0C_ENST00000565223.1_Missense_Mutation_p.A73S	NM_001198569.1|NM_001694.3	NP_001185498.1|NP_001685.1	P27449	VATL_HUMAN	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	116					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|interspecies interaction between organisms|transferrin transport	endosome membrane|integral to membrane|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|ubiquitin protein ligase binding			endometrium(1)|lung(1)|ovary(1)	3		Ovarian(90;0.17)				CGTGGGGGACGCTGGCGTGCG	0.687000													7	11					3.09899e-07	3.9551e-07	0.307466	1	0
PLA2G5	5322	broad.mit.edu	37	1	20417116	20417116	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:20417116C>T	ENST00000375108.3	+	5	616	c.348C>T	c.(346-348)taC>taT	p.Y116Y	PLA2G5_ENST00000486277.1_3'UTR	NM_000929.2	NP_000920.1	P39877	PA2G5_HUMAN	phospholipase A2, group V	116					lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity			NS(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		AGCTCGTCTACTGCCTCAAGA	0.567000													23	41					0	0	0.667858	0	0
OR14J1	442191	broad.mit.edu	37	6	29274852	29274852	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:29274852A>C	ENST00000377160.2	+	1	450	c.386A>C	c.(385-387)cAt>cCt	p.H129P		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						CAACCACTTCATTATGAGACT	0.483000													20	63					0	0	0.654019	0	0
ABL2	27	broad.mit.edu	37	1	179090797	179090797	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:179090797T>A	ENST00000502732.1	-	5	1096	c.893A>T	c.(892-894)cAg>cTg	p.Q298L	ABL2_ENST00000504405.1_Missense_Mutation_p.Q262L|ABL2_ENST00000507173.1_Missense_Mutation_p.Q277L|ABL2_ENST00000408940.3_Missense_Mutation_p.Q262L|ABL2_ENST00000512653.1_Missense_Mutation_p.Q283L|ABL2_ENST00000511413.1_Missense_Mutation_p.Q298L|ABL2_ENST00000344730.3_Missense_Mutation_p.Q283L|ABL2_ENST00000392043.3_Missense_Mutation_p.Q277L|ABL2_ENST00000367623.4_Missense_Mutation_p.Q277L	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	298	Protein kinase.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	CTCTCCATACTGACCGCCCCC	0.458000			T	ETV6	AML								42	119					0	0	0.840704	0	0
SPTBN5	51332	broad.mit.edu	37	15	42164514	42164514	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:42164514C>A	ENST00000320955.6	-	27	5378	c.5151G>T	c.(5149-5151)gaG>gaT	p.E1717D		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1717					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TGGCCGCCAACTCCTGCAGTG	0.627000													3	23					0.150653	0.153678	0.150653	1	0
DCAF12L1	139170	broad.mit.edu	37	X	125685464	125685464	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:125685464G>A	ENST00000371126.1	-	1	1370	c.1128C>T	c.(1126-1128)gaC>gaT	p.D376D		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	376										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						GGGCCCGGACGTCATAGAAGA	0.627000													23	26					0	0	0.706142	0	0
FCRL5	83416	broad.mit.edu	37	1	157491068	157491068	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:157491068G>A	ENST00000361835.3	-	11	2411	c.2254C>T	c.(2254-2256)Ccg>Tcg	p.P752S	FCRL5_ENST00000356953.4_Missense_Mutation_p.P752S|FCRL5_ENST00000461387.1_5'UTR	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	752	Ig-like C2-type 8.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				GTGAGGACCGGGCGAGACACC	0.512000													12	61					0	0	0.479597	0	0
CDH22	64405	broad.mit.edu	37	20	44856203	44856203	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:44856203C>A	ENST00000372262.3	-	3	1014	c.614G>T	c.(613-615)cGg>cTg	p.R205L	CDH22_ENST00000537909.1_Missense_Mutation_p.R205L	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	205	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GTACACCAGCCGAGCGCTGCT	0.711000													16	38					3.73194e-20	6.47874e-20	0.592651	1	0
SEMA4C	54910	broad.mit.edu	37	2	97530493	97530493	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:97530493T>C	ENST00000305476.5	-	9	1043	c.911A>G	c.(910-912)cAg>cGg	p.Q304R		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	304	Dominant negative effect on myogenic differentiation (By similarity).|Sema.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						GGAGGTGTCCTGCAGGGTGTG	0.607000													23	56					0	0	0.693898	0	0
CSH2	1443	broad.mit.edu	37	17	61950681	61950681	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:61950681A>G	ENST00000336844.5	-	2	180	c.29T>C	c.(28-30)cTc>cCc	p.L10P	CSH2_ENST00000345366.7_Missense_Mutation_p.L10P|CSH2_ENST00000392886.2_Missense_Mutation_p.L10P|CSH2_ENST00000560142.1_Missense_Mutation_p.L10P	NM_022644.3	NP_072170.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	10					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						AAAAGCCAGGAGCAGGGACGT	0.612000													3	32					0	0	0.307466	0	0
NRG1	3084	broad.mit.edu	37	8	32585533	32585533	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:32585533G>T	ENST00000341377.5	+	6	1086	c.569G>T	c.(568-570)tGt>tTt	p.C190F	NRG1_ENST00000539990.1_Missense_Mutation_p.C36F|NRG1_ENST00000519301.1_Missense_Mutation_p.C135F|NRG1_ENST00000287840.5_Missense_Mutation_p.C190F|NRG1_ENST00000338921.4_Missense_Mutation_p.C190F|NRG1_ENST00000520502.2_Missense_Mutation_p.C245F|NRG1_ENST00000356819.4_Missense_Mutation_p.C190F|NRG1_ENST00000287842.3_Missense_Mutation_p.C190F|NRG1_ENST00000521670.1_Missense_Mutation_p.C190F|NRG1_ENST00000287845.5_Missense_Mutation_p.C156F|NRG1_ENST00000523079.1_Missense_Mutation_p.C190F|NRG1_ENST00000405005.2_Missense_Mutation_p.C190F|NRG1_ENST00000520407.1_Missense_Mutation_p.C371F			Q02297	NRG1_HUMAN	neuregulin 1	190	EGF-like.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		AAAACTTTCTGTGTGAATGGA	0.438000													22	92					1.17739e-12	1.77882e-12	0.693898	1	0
EPHA6	285220	broad.mit.edu	37	3	97124081	97124081	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:97124081G>T	ENST00000389672.5	+	6	1732	c.1694G>T	c.(1693-1695)gGa>gTa	p.G565V		NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	470						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						TTTTCCAATGGAGCCATTCTG	0.403000													9	13					1.61879e-10	2.25101e-10	0.411799	1	0
RELN	5649	broad.mit.edu	37	7	103191669	103191669	+	Silent	SNP	C	C	G	rs116750302	by1000genomes	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:103191669C>G	ENST00000428762.1	-	41	6306	c.6147G>C	c.(6145-6147)gcG>gcC	p.A2049A	RELN_ENST00000343529.5_Silent_p.A2049A|RELN_ENST00000424685.2_Silent_p.A2049A	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2049					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGTGCCAGGTCGCCCCGAAGT	0.547000													10	40					0	0	0.361761	0	0
C11orf87	399947	broad.mit.edu	37	11	109294741	109294741	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:109294741G>T	ENST00000327419.6	+	2	785	c.382G>T	c.(382-384)Gaa>Taa	p.E128*	RP11-708B6.2_ENST00000532992.1_RNA|RP11-708B6.2_ENST00000532929.1_RNA	NM_207645.3	NP_997528.2	Q6NUJ2	CK087_HUMAN	chromosome 11 open reading frame 87	128						integral to membrane				breast(2)|endometrium(1)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|urinary_tract(1)	17						CCACGCAAAGGAAACCCGGCT	0.701000													22	32					1.04121e-07	1.35673e-07	0.693898	1	0
CSMD1	64478	broad.mit.edu	37	8	3263564	3263564	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:3263564C>T	ENST00000520002.1	-	16	2809	c.2254G>A	c.(2254-2256)Gtg>Atg	p.V752M	CSMD1_ENST00000542608.1_Missense_Mutation_p.V751M|CSMD1_ENST00000602723.1_Missense_Mutation_p.V752M|CSMD1_ENST00000400186.3_Missense_Mutation_p.V752M|CSMD1_ENST00000602557.1_Missense_Mutation_p.V752M|CSMD1_ENST00000539096.1_Missense_Mutation_p.V751M|CSMD1_ENST00000537824.1_Missense_Mutation_p.V751M			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	752	Sushi 4.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGCGGGGCACGGTGGAGCTC	0.532000													18	38					0	0	0.681144	0	0
FBN2	2201	broad.mit.edu	37	5	127647596	127647596	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:127647596G>T	ENST00000508053.1	-	44	5903	c.4929C>A	c.(4927-4929)ccC>ccA	p.P1643P	FBN2_ENST00000262464.4_Silent_p.P1643P			P35556	FBN2_HUMAN	fibrillin 2	1643					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGATTGTGATGGGGTTAGGTC	0.418000													7	43					7.48243e-07	9.31554e-07	0.335167	1	0
MMP16	4325	broad.mit.edu	37	8	89128822	89128822	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:89128822G>T	ENST00000286614.6	-	6	1278	c.997C>A	c.(997-999)Ccc>Acc	p.P333T	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	333					collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GGATAGGAGGGTCTGCCGGTT	0.522000													22	52					1.10513e-12	1.67872e-12	0.624587	1	0
RASAL2	9462	broad.mit.edu	37	1	178410734	178410734	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:178410734G>C	ENST00000448150.3	+	7	1643	c.825G>C	c.(823-825)gaG>gaC	p.E275D	RASAL2_ENST00000367649.3_Missense_Mutation_p.E293D|RASAL2_ENST00000462775.1_Missense_Mutation_p.E145D	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	145					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						CTGCTTCTGAGAGAGACAAGT	0.343000													19	54					0	0	0.706142	0	0
IFI16	3428	broad.mit.edu	37	1	159023409	159023409	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:159023409A>T	ENST00000295809.7	+	11	2427	c.2172A>T	c.(2170-2172)acA>acT	p.T724T	IFI16_ENST00000368131.4_Silent_p.T668T|IFI16_ENST00000430894.2_Silent_p.T672T|IFI16_ENST00000368132.3_Silent_p.T668T|IFI16_ENST00000359709.3_Silent_p.T668T|IFI16_ENST00000340979.6_Silent_p.T612T|IFI16_ENST00000448393.2_Silent_p.T612T			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	724	HIN-200 2.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					GACTGACCACAATCAACTGTG	0.403000													74	122					0	0	0.870114	0	0
DST	667	broad.mit.edu	37	6	56494059	56494059	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:56494059C>A	ENST00000370754.5	-	31	4364	c.4365G>T	c.(4363-4365)caG>caT	p.Q1455H	DST_ENST00000370769.4_Missense_Mutation_p.Q1277H|DST_ENST00000370765.6_Missense_Mutation_p.Q951H|DST_ENST00000370788.2_Missense_Mutation_p.Q1277H|DST_ENST00000361203.3_Missense_Mutation_p.Q1277H|DST_ENST00000312431.6_Missense_Mutation_p.Q1277H|DST_ENST00000518935.1_Missense_Mutation_p.Q951H|DST_ENST00000446842.2_Missense_Mutation_p.Q951H|DST_ENST00000421834.2_Missense_Mutation_p.Q1277H|DST_ENST00000244364.6_Missense_Mutation_p.Q951H			Q03001	DYST_HUMAN	dystonin	1277					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGTTGTCAATCTGCACATGAA	0.323000													20	106					2.41591e-17	4.08004e-17	0.681144	1	0
CSMD1	64478	broad.mit.edu	37	8	3046476	3046476	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:3046476G>T	ENST00000520002.1	-	36	6014	c.5459C>A	c.(5458-5460)cCt>cAt	p.P1820H	CSMD1_ENST00000542608.1_Missense_Mutation_p.P1819H|CSMD1_ENST00000602723.1_Missense_Mutation_p.P1820H|CSMD1_ENST00000400186.3_Missense_Mutation_p.P1820H|CSMD1_ENST00000602557.1_Missense_Mutation_p.P1820H|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000539096.1_Missense_Mutation_p.P1819H|CSMD1_ENST00000537824.1_Missense_Mutation_p.P1819H			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1820	CUB 11.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GTATGGCTCAGGGTAGCCGGG	0.473000													8	23					0.000157383	0.000178092	0.278610	1	0
PTPRC	5788	broad.mit.edu	37	1	198721821	198721821	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:198721821C>A	ENST00000367376.2	+	31	3594	c.3423C>A	c.(3421-3423)gtC>gtA	p.V1141V	PTPRC_ENST00000352140.3_Silent_p.V1093V|PTPRC_ENST00000594404.1_Silent_p.V980V|PTPRC_ENST00000442510.2_Silent_p.V1143V|PTPRC_ENST00000348564.6_Silent_p.V982V	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	1141	Tyrosine-protein phosphatase 2.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TGATTCAGGTCGTCAAACAAA	0.448000													13	39					0.000422831	0.000471782	0.500413	1	0
ARHGAP15	55843	broad.mit.edu	37	2	144276912	144276912	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:144276912A>C	ENST00000295095.6	+	10	1071	c.904A>C	c.(904-906)Att>Ctt	p.I302L	RP11-570L15.1_ENST00000553076.1_RNA|RP11-570L15.2_ENST00000546678.1_RNA	NM_018460.3	NP_060930.3	Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	302	Rho-GAP.				regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		AAAGCAATGCATTGAAGCTGT	0.443000													44	76					0	0	0.870114	0	0
PPP1R26	9858	broad.mit.edu	37	9	138376995	138376995	+	Silent	SNP	G	G	T	rs145406252	byFrequency	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:138376995G>T	ENST00000356818.2	+	4	1188	c.639G>T	c.(637-639)ccG>ccT	p.P213P	PPP1R26_ENST00000605286.1_Silent_p.P213P|PPP1R26_ENST00000605660.1_Silent_p.P213P|PPP1R26_ENST00000604351.1_Silent_p.P213P|PPP1R26_ENST00000401470.3_Silent_p.P213P|PPP1R26_ENST00000602993.1_Intron	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	213						nucleolus	protein binding										CCGCCTCCCCGGTCAGTGTGA	0.582000													8	66					1.10513e-12	1.67872e-12	0.624587	1	0
PTPRH	5794	broad.mit.edu	37	19	55715189	55715189	+	Nonsense_Mutation	SNP	C	C	A	rs141593423		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:55715189C>A	ENST00000376350.3	-	5	869	c.847G>T	c.(847-849)Gga>Tga	p.G283*	PTPRH_ENST00000263434.5_Intron|PTPRH_ENST00000588559.1_5'UTR	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	283	Fibronectin type-III 3.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CTATTTACTCCGTCTTTCTCC	0.483000													36	178					3.54561e-26	6.51972e-26	0.847076	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125298989	125298989	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:125298989G>T	ENST00000538699.1	-	2	999	c.919C>A	c.(919-921)Cga>Aga	p.R307R	DCAF12L2_ENST00000360028.2_Silent_p.R307R	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	307								p.R307R(2)		NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						ACATTCTCTCGGCAGTAGGGC	0.607000													86	157					2.19568e-55	4.2766e-55	0.870114	1	0
PITPNC1	26207	broad.mit.edu	37	17	65665684	65665684	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:65665684G>T	ENST00000580974.1	+	7	1219	c.523G>T	c.(523-525)Gat>Tat	p.D175Y	PITPNC1_ENST00000581322.1_Missense_Mutation_p.D175Y|PITPNC1_ENST00000299954.9_Missense_Mutation_p.D175Y|PITPNC1_ENST00000335257.6_Missense_Mutation_p.D175Y	NM_012417.3|NM_181671.2	NP_036549.2|NP_858057.1	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein, cytoplasmic 1	175					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			breast(1)|kidney(2)|large_intestine(3)|liver(2)|lung(4)|prostate(2)|skin(3)	17	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			AGGCTGGAGAGATAGTCATCA	0.428000													3	15					0.184627	0.187648	0.184627	1	0
COL9A3	1299	broad.mit.edu	37	20	61453472	61453472	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:61453472G>A	ENST00000343916.3	+	9	436	c.433G>A	c.(433-435)Gga>Aga	p.G145R		NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	145	Triple-helical region 3 (COL3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					GGGACCTTCTGGACTCCCCGG	0.647000													15	44					0	0	0.608945	0	0
PLEKHB2	55041	broad.mit.edu	37	2	132110650	132110650	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:132110650G>C	ENST00000404460.1	+	7	535	c.481G>C	c.(481-483)Gtt>Ctt	p.V161L	PLEKHB2_ENST00000303908.3_Missense_Mutation_p.V161L			Q96CS7	PKHB2_HUMAN	pleckstrin homology domain containing, family B (evectins) member 2	0						membrane	protein binding			large_intestine(1)|lung(3)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.0828)		AACCCAGGCGGTTCTCCCAAC	0.448000													4	17					0	0	0.278610	0	0
LRP1B	53353	broad.mit.edu	37	2	141526835	141526835	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:141526835G>C	ENST00000389484.3	-	35	6676	c.5705C>G	c.(5704-5706)gCt>gGt	p.A1902G		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1902					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGGCATCAAAGCATCCATTTT	0.363000										TSP Lung(27;0.18)			20	74					0	0	0.624587	0	0
ADARB2	105	broad.mit.edu	37	10	1779262	1779262	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:1779262C>A	ENST00000381312.1	-	1	408	c.83G>T	c.(82-84)cGg>cTg	p.R28L		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	28					mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		CTTGGACCTCCGCCTCCTCCT	0.692000													22	63					4.59853e-10	6.31592e-10	0.693898	1	0
CD4	920	broad.mit.edu	37	12	6924037	6924037	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:6924037C>A	ENST00000011653.4	+	5	744	c.486C>A	c.(484-486)aaC>aaA	p.N162K	CD4_ENST00000538827.1_3'UTR|CD4_ENST00000541982.1_Missense_Mutation_p.N107K	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	162	Ig-like C2-type 1.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				GGGGTAAAAACATACAGGGGG	0.577000													18	57					9.7654e-05	0.000112554	0.557998	1	0
F8	2157	broad.mit.edu	37	X	154132600	154132600	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:154132600G>T	ENST00000360256.4	-	17	5986	c.5786C>A	c.(5785-5787)cCc>cAc	p.P1929H		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1929	F5/8 type A 3.|Plastocyanin-like 6.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTTAAAAGTGGGATCTTCCAT	0.393000													38	310					2.81731e-22	5.01552e-22	0.870114	1	0
TENM2	57451	broad.mit.edu	37	5	167379677	167379677	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:167379677C>A	ENST00000519204.1	+	3	552	c.434C>A	c.(433-435)tCc>tAc	p.S145Y	TENM2_ENST00000518659.1_Missense_Mutation_p.S266Y|CTC-353G13.1_ENST00000523050.1_RNA|TENM2_ENST00000520393.1_3'UTR|TENM2_ENST00000545108.1_Missense_Mutation_p.S266Y|TENM2_ENST00000520394.1_Missense_Mutation_p.S75Y|TENM2_ENST00000403607.2_Missense_Mutation_p.S99Y					teneurin transmembrane protein 2																		CACCACTCGTCCGCCAACTCC	0.622000													8	27					3.07112e-06	3.70789e-06	0.387290	1	0
GLE1	2733	broad.mit.edu	37	9	131289491	131289491	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:131289491A>T	ENST00000309971.4	+	8	1269	c.1163A>T	c.(1162-1164)cAg>cTg	p.Q388L	GLE1_ENST00000539582.1_Missense_Mutation_p.Q134L|GLE1_ENST00000494417.1_3'UTR|GLE1_ENST00000372770.4_Missense_Mutation_p.Q388L	NM_001003722.1	NP_001003722.1	Q53GS7	GLE1_HUMAN	GLE1 RNA export mediator	388					poly(A)+ mRNA export from nucleus|protein transport|transmembrane transport	cytoplasm|nuclear pore	protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	16						ATTACAATGCAGTGGTACCAG	0.463000													13	44					0	0	0.539581	0	0
IFNG	3458	broad.mit.edu	37	12	68552024	68552024	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:68552024C>A	ENST00000229135.3	-	2	261	c.130G>T	c.(130-132)Gat>Tat	p.D44Y	IFNG-AS1_ENST00000536914.1_RNA	NM_000619.2	NP_000610.2	P01579	IFNG_HUMAN	interferon, gamma	44					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	TCCGCTACATCTGAATGACCT	0.313000													8	14					2.52707e-12	3.78721e-12	0.335167	1	0
ZNF615	284370	broad.mit.edu	37	19	52497146	52497146	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:52497146T>C	ENST00000602063.1	-	6	1532	c.1183A>G	c.(1183-1185)Aca>Gca	p.T395A	ZNF615_ENST00000598071.1_Missense_Mutation_p.T406A|ZNF615_ENST00000594083.1_Missense_Mutation_p.T406A|ZNF615_ENST00000391795.3_Missense_Mutation_p.T400A|ZNF615_ENST00000376716.5_Missense_Mutation_p.T395A			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TTCTCTCCTGTATGAGTTTGC	0.383000													10	46					0	0	0.435327	0	0
PIK3R1	5295	broad.mit.edu	37	5	67593402	67593402	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:67593402C>T	ENST00000521381.1	+	16	2764	c.2148C>T	c.(2146-2148)taC>taT	p.Y716Y	PIK3R1_ENST00000336483.5_Silent_p.Y446Y|PIK3R1_ENST00000320694.8_Silent_p.Y416Y|PIK3R1_ENST00000521657.1_Silent_p.Y716Y|PIK3R1_ENST00000274335.5_Silent_p.Y716Y|PIK3R1_ENST00000523872.1_Silent_p.Y353Y|PIK3R1_ENST00000396611.1_Silent_p.Y724Y	NM_181523.2	NP_852664.1	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	716	SH2 2.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.0?(1)|p.?(1)		breast(12)|central_nervous_system(31)|cervix(1)|endometrium(68)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(32)|lung(10)|ovary(9)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	178		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CACTAGCCTACCCAGTATATG	0.512000			"""Mis, F, O"""		"""gliobastoma, ovarian, colorectal"""					TCGA GBM(4;<1E-08)			85	165					0	0	0.870114	0	0
SPOP	8405	broad.mit.edu	37	17	47688725	47688725	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:47688725C>G	ENST00000393331.3	-	8	1045	c.575G>C	c.(574-576)gGa>gCa	p.G192A	SPOP_ENST00000393328.2_Missense_Mutation_p.G192A|SPOP_ENST00000347630.2_Missense_Mutation_p.G192A|SPOP_ENST00000504102.1_Missense_Mutation_p.G192A|SPOP_ENST00000503676.1_Missense_Mutation_p.G192A	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	192	BTB.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						CTCCCACAGTCCTCCTAACTC	0.493000										Prostate(2;0.17)			46	160					0	0	0.870114	0	0
NOL11	25926	broad.mit.edu	37	17	65716058	65716058	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:65716058G>T	ENST00000253247.4	+	3	407	c.292G>T	c.(292-294)Gat>Tat	p.D98Y	NOL11_ENST00000535137.1_5'UTR|NOL11_ENST00000581966.1_3'UTR	NM_015462.3	NP_056277.2	Q9H8H0	NOL11_HUMAN	nucleolar protein 11	98						nucleolus				haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	11	all_cancers(12;1.54e-10)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0518)|COAD - Colon adenocarcinoma(4;0.0977)|LUSC - Lung squamous cell carcinoma(166;0.24)			TGTAAACCTGGATAAAGTATT	0.234000													8	33					0.335167	0.340034	0.335167	1	0
CD22	933	broad.mit.edu	37	19	35832688	35832688	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:35832688G>T	ENST00000085219.5	+	9	1921	c.1855G>T	c.(1855-1857)Gac>Tac	p.D619Y	CD22_ENST00000594250.1_Missense_Mutation_p.D442Y|CD22_ENST00000536635.2_Missense_Mutation_p.D531Y|CD22_ENST00000419549.2_Missense_Mutation_p.D447Y|CD22_ENST00000341773.6_Missense_Mutation_p.D442Y|CD22_ENST00000270311.6_Missense_Mutation_p.D499Y|CD22_ENST00000544992.2_Missense_Mutation_p.D619Y	NM_001771.3	NP_001762.2	P20273	CD22_HUMAN	CD22 molecule	619	Ig-like C2-type 6.				cell adhesion		protein binding|sugar binding	p.D619N(1)		breast(2)|endometrium(2)|kidney(3)|large_intestine(14)|lung(21)|ovary(5)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	54	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.83e-19)|OV - Ovarian serous cystadenocarcinoma(14;3.19e-18)|all cancers(14;3.41e-16)|LUSC - Lung squamous cell carcinoma(66;0.0417)		OspA lipoprotein(DB00045)	CTGTGAGAGCGACGCCAACCC	0.612000													9	40					0.0931896	0.0962901	0.411799	1	0
DSG4	147409	broad.mit.edu	37	18	28956922	28956922	+	Splice_Site	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:28956922G>T	ENST00000359747.4	+	1	77	c.48_splice	c.e1+1	p.M16_splice	DSG4_ENST00000308128.4_Splice_Site_p.M16_splice|RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000581452.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	16					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding	p.M16I(2)		NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			TCATTCTAATGGTAAGTAGAA	0.408000													10	15					4.68919e-08	6.15319e-08	0.361761	1	0
CHL1	10752	broad.mit.edu	37	3	436553	436553	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:436553G>T	ENST00000256509.2	+	24	3734	c.3092G>T	c.(3091-3093)gGg>gTg	p.G1031V	CHL1_ENST00000397491.2_Missense_Mutation_p.G1015V	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	1015					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTAGGAGAAGGGAGTAAGTAC	0.443000													7	21					0.000157383	0.000178092	0.278610	1	0
ABCB1	5243	broad.mit.edu	37	7	87183173	87183173	+	Silent	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:87183173A>G	ENST00000265724.3	-	10	1320	c.903T>C	c.(901-903)gcT>gcC	p.A301A	ABCB1_ENST00000543898.1_Silent_p.A237A	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	301	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GCAGGAAAGCAGCACCTATAG	0.383000													34	75					0	0	0.840704	0	0
PAMR1	25891	broad.mit.edu	37	11	35454341	35454341	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:35454341C>A	ENST00000378880.2	-	11	2171	c.1726G>T	c.(1726-1728)Gtc>Ttc	p.V576F	PAMR1_ENST00000378878.3_Missense_Mutation_p.V465F|PAMR1_ENST00000278360.3_Missense_Mutation_p.V593F|PAMR1_ENST00000532848.1_Missense_Mutation_p.V536F	NM_001001991.1	NP_001001991.1	Q6UXH9	PAMR1_HUMAN	peptidase domain containing associated with muscle regeneration 1	576	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	26						ATGGGCTGGACTCGGGTGCTG	0.567000													19	63					3.8784e-16	6.28414e-16	0.608945	1	0
NAT9	26151	broad.mit.edu	37	17	72768373	72768373	+	Silent	SNP	G	G	A	rs151031640		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:72768373G>A	ENST00000357814.3	-	5	451	c.378C>T	c.(376-378)ctC>ctT	p.L126L	NAT9_ENST00000583757.1_Silent_p.L125L|NAT9_ENST00000581136.1_Silent_p.L126L|NAT9_ENST00000583476.1_Silent_p.L126L|NAT9_ENST00000580632.1_Intron|NAT9_ENST00000580301.1_Silent_p.L125L|NAT9_ENST00000582870.1_Silent_p.L130L|NAT9_ENST00000582524.1_Silent_p.L126L|NAT9_ENST00000578822.1_Silent_p.L131L	NM_015654.3	NP_056469.2	Q9BTE0	NAT9_HUMAN	N-acetyltransferase 9 (GCN5-related, putative)	126	N-acetyltransferase.			L -> P (in Ref. 3; CAB43370).		protein complex	N-acetyltransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)	8						ACAGCATCGCGAGAACGGCCT	0.617000													13	38					0	0	0.539581	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35500182	35500182	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:35500182G>T	ENST00000599564.1	+	3	500	c.429G>T	c.(427-429)ggG>ggT	p.G143G	GRAMD1A_ENST00000317991.5_Silent_p.G56G|GRAMD1A_ENST00000504615.2_5'UTR|GRAMD1A_ENST00000598073.1_3'UTR|GRAMD1A_ENST00000411896.2_Silent_p.G56G|GRAMD1A_ENST00000424536.2_Silent_p.G56G			Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A	56	GRAM.					integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GGGTGCCTGGGACCCCCAGCA	0.662000													15	34					1.96292e-10	2.70932e-10	0.592651	1	0
LRRC30	339291	broad.mit.edu	37	18	7231580	7231580	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:7231580G>A	ENST00000383467.2	+	1	458	c.444G>A	c.(442-444)tcG>tcA	p.S148S		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	148										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						TGAGCTTGTCGCACAACTGCC	0.567000													6	47					0	0	0.278610	0	0
MYO10	4651	broad.mit.edu	37	5	16764426	16764426	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:16764426C>T	ENST00000513610.1	-	12	1713	c.1259G>A	c.(1258-1260)aGg>aAg	p.R420K		NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	420	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						GCCTTTGATCCTGCTGTTGAT	0.483000													21	76					0	0	0.592651	0	0
DOCK3	1795	broad.mit.edu	37	3	51126673	51126673	+	Splice_Site	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:51126673G>C	ENST00000266037.9	+	8	572		c.e8-1			NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3							cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCTTTCCATAGCATTTATCTA	0.403000													4	12					0	0	0.184627	0	0
HYAL4	23553	broad.mit.edu	37	7	123508357	123508357	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:123508357G>T	ENST00000223026.4	+	3	668	c.30G>T	c.(28-30)aaG>aaT	p.K10N	HYAL4_ENST00000476325.1_Missense_Mutation_p.K10N	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	10					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						GACAGTTAAAGCTTTGTGTTG	0.338000													30	80					6.97489e-18	1.18509e-17	0.804634	1	0
PPP2R1A	5518	broad.mit.edu	37	19	52714572	52714572	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:52714572G>T	ENST00000322088.6	+	4	388	c.330G>T	c.(328-330)gaG>gaT	p.E110D	PPP2R1A_ENST00000473455.2_3'UTR|PPP2R1A_ENST00000462990.1_5'UTR|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.E55D	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	110	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		AGGCAGTGGAGTCCTTACGGG	0.637000			Mis		clear cell ovarian carcinoma								9	28					0.000978159	0.00107425	0.387290	1	0
DONSON	29980	broad.mit.edu	37	21	34957030	34957030	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr21:34957030G>T	ENST00000453626.1	-	4	655	c.651C>A	c.(649-651)agC>agA	p.S217R	AP000304.12_ENST00000429238.1_Missense_Mutation_p.P179T|DONSON_ENST00000303113.6_Missense_Mutation_p.S203R|DONSON_ENST00000303071.5_Missense_Mutation_p.S217R|DONSON_ENST00000432378.1_Missense_Mutation_p.S217R			Q9NYP3	DONS_HUMAN	downstream neighbor of SON	217					multicellular organismal development	nucleus				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|ovary(1)	11						AATAGATAAGGCTCTGCTGGA	0.458000													6	17					1.06961e-07	1.3905e-07	0.278610	1	0
GATA1	2623	broad.mit.edu	37	X	48651663	48651663	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:48651663C>T	ENST00000376670.3	+	5	940	c.829C>T	c.(829-831)Ccc>Tcc	p.P277S	GATA1_ENST00000376665.3_Missense_Mutation_p.P277S	NM_002049.3	NP_002040.1	P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	277					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						CAGTGGGGATCCCGTGTGCAA	0.597000			"""Mis, F"""		megakaryoblastic leukemia of Downs Syndrome								14	66					0	0	0.520397	0	0
RBFOX1	54715	broad.mit.edu	37	16	7568297	7568297	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:7568297C>A	ENST00000340209.4	+	2	488	c.191C>A	c.(190-192)cCc>cAc	p.P64H	RBFOX1_ENST00000553186.1_Missense_Mutation_p.P59H|RBFOX1_ENST00000355637.4_Missense_Mutation_p.P79H|RBFOX1_ENST00000535565.2_Missense_Mutation_p.P95H|RBFOX1_ENST00000550418.1_Missense_Mutation_p.P59H|RBFOX1_ENST00000547372.1_Missense_Mutation_p.P102H|RBFOX1_ENST00000552089.1_Missense_Mutation_p.P95H|RBFOX1_ENST00000547338.1_Missense_Mutation_p.P59H|RBFOX1_ENST00000436368.2_Missense_Mutation_p.P79H|RBFOX1_ENST00000422070.4_Missense_Mutation_p.P102H|RBFOX1_ENST00000311745.5_Missense_Mutation_p.P79H			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	59					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						ACCACGGTTCCCGAGCACACA	0.657000													57	164					1.43675e-24	2.63327e-24	0.870114	1	0
VN1R4	317703	broad.mit.edu	37	19	53770284	53770284	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:53770284C>A	ENST00000311170.4	-	1	688	c.635G>T	c.(634-636)cGg>cTg	p.R212L		NM_173857.2	NP_776256.2	Q7Z5H5	VN1R4_HUMAN	vomeronasal 1 receptor 4	212					response to pheromone	actin cytoskeleton|cytoplasm|integral to membrane|plasma membrane	pheromone receptor activity			central_nervous_system(1)|large_intestine(4)|lung(10)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	22				GBM - Glioblastoma multiforme(134;0.00294)		GTGCTGGACCCGCTGCTTGTG	0.542000										HNSCC(26;0.072)			5	20					2.0095e-06	2.44198e-06	0.248553	1	0
PROS1	5627	broad.mit.edu	37	3	93617365	93617365	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:93617365T>A	ENST00000394236.3	-	8	1092	c.776A>T	c.(775-777)tAc>tTc	p.Y259F	PROS1_ENST00000407433.1_Missense_Mutation_p.Y128F	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	259	EGF-like 4; calcium-binding (Potential).				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	ACCTCCAGGGTAATTGACACA	0.378000													6	67					0	0	0.248553	0	0
PCDH9	5101	broad.mit.edu	37	13	67205366	67205366	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:67205366C>A	ENST00000544246.1	-	4	4007	c.3316G>T	c.(3316-3318)Gat>Tat	p.D1106Y	PCDH9_ENST00000328454.5_Missense_Mutation_p.D1072Y|PCDH9_ENST00000377865.2_Missense_Mutation_p.D1106Y|PCDH9_ENST00000456367.1_Missense_Mutation_p.D1072Y	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1106					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GAGTTGCCATCTGCTTCAGTC	0.488000													25	56					2.65835e-16	4.33241e-16	0.717897	1	0
ABCC1	4363	broad.mit.edu	37	16	16225669	16225669	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:16225669A>T	ENST00000399408.2	+	28	4048	c.3873A>T	c.(3871-3873)acA>acT	p.T1291T	ABCC1_ENST00000345148.5_Silent_p.T1281T|ABCC1_ENST00000351154.5_Silent_p.T1222T|ABCC1_ENST00000349029.5_Silent_p.T1166T|ABCC1_ENST00000399410.3_Silent_p.T1281T|ABCC1_ENST00000346370.5_Silent_p.T1225T			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1281					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	TCCAGGAGACAGCTCCGCCCA	0.592000													5	21					0	0	0.217242	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20890069	20890069	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:20890069G>T	ENST00000381552.1	+	11	1779	c.1411G>T	c.(1411-1413)Gct>Tct	p.A471S	SLCO1C1_ENST00000266509.2_Missense_Mutation_p.A471S|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.A422S|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.A471S|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.A353S			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	471	Kazal-like.				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TCATGAACGAGCTCTCTTTTC	0.358000													4	29					0.150653	0.153678	0.150653	1	0
AMMECR1	9949	broad.mit.edu	37	X	109441767	109441767	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:109441767G>T	ENST00000262844.5	-	6	1150	c.983C>A	c.(982-984)cCa>cAa	p.P328Q	AMMECR1_ENST00000372057.1_Missense_Mutation_p.P205Q|AMMECR1_ENST00000372059.2_Missense_Mutation_p.P291Q	NM_015365.2	NP_056180.1	Q9Y4X0	AMER1_HUMAN	Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1	328										large_intestine(1)|lung(4)|ovary(1)|stomach(1)	7						ATGGTTGTATGGCGGAAGGGG	0.502000													12	67					5.3912e-06	6.43949e-06	0.539581	1	0
COL4A1	1282	broad.mit.edu	37	13	110815875	110815875	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:110815875G>T	ENST00000375820.4	-	47	4305	c.4184C>A	c.(4183-4185)cCa>cAa	p.P1395Q		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	1395	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			AGGAATACCTGGAGGTCCAGG	0.493000													9	14					0.00010058	0.000115688	0.411799	1	0
NLRP14	338323	broad.mit.edu	37	11	7063863	7063863	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:7063863G>T	ENST00000299481.4	+	4	952	c.606G>T	c.(604-606)gaG>gaT	p.E202D		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	202	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ATTGGGCAGAGGGCAGTCTCT	0.453000													17	71					2.89027e-11	4.16407e-11	0.624587	1	0
TMEM132E	124842	broad.mit.edu	37	17	32961820	32961820	+	Nonsense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:32961820C>G	ENST00000321639.5	+	8	1749	c.1421C>G	c.(1420-1422)tCa>tGa	p.S474*		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	474						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CACCCCAGGTCAGTCCGGGAA	0.637000													3	9					0	0	0.115264	0	0
HTR1A	3350	broad.mit.edu	37	5	63257442	63257442	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:63257442G>T	ENST00000323865.3	-	1	338	c.105C>A	c.(103-105)taC>taA	p.Y35*	RP11-158J3.2_ENST00000502882.1_RNA	NM_000524.3	NP_000515.2	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled	35					behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(29)|ovary(2)|pancreas(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	56		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGATCACTTGGTAGCTGACGG	0.617000													21	59					3.83957e-06	4.62569e-06	0.639603	1	0
OBSCN	84033	broad.mit.edu	37	1	228471312	228471312	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:228471312G>T	ENST00000570156.2	+	38	10207	c.10133G>T	c.(10132-10134)cGc>cTc	p.R3378L	OBSCN_ENST00000366707.4_Missense_Mutation_p.R68L|OBSCN_ENST00000359599.6_Missense_Mutation_p.R1796L|OBSCN_ENST00000284548.11_Missense_Mutation_p.R2949L|OBSCN_ENST00000366709.4_Missense_Mutation_p.R68L|OBSCN_ENST00000422127.1_Missense_Mutation_p.R2949L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2413	Ig-like 34.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GTGACCTGGCGCAAGGGCCTC	0.637000													9	17					4.68919e-08	6.15319e-08	0.361761	1	0
LMNB2	84823	broad.mit.edu	37	19	2438518	2438518	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:2438518C>A	ENST00000325327.3	-	3	475	c.413G>T	c.(412-414)aGg>aTg	p.R138M	LMNB2_ENST00000582871.1_Missense_Mutation_p.R118M			Q03252	LMNB2_HUMAN	lamin B2	118	Coil 1B.|Rod.					nuclear inner membrane	structural molecule activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCGCCCTCCCTCTTCTTGGC	0.657000													9	20					0.000151284	0.000172588	0.435327	1	0
MYO16	23026	broad.mit.edu	37	13	109475582	109475582	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:109475582C>A	ENST00000356711.2	+	9	1113	c.987C>A	c.(985-987)ccC>ccA	p.P329P	MYO16_ENST00000251041.5_Silent_p.P329P|MYO16_ENST00000357550.2_Silent_p.P329P	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	329					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			AAGAAGAGCCCTATGAAGAGA	0.428000													23	90					1.66031e-10	2.2973e-10	0.667858	1	0
KCNC4	3749	broad.mit.edu	37	1	110766455	110766455	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:110766455G>T	ENST00000369787.3	+	2	1575	c.1548G>T	c.(1546-1548)cgG>cgT	p.R516R	KCNC4_ENST00000438661.2_Silent_p.R516R|KCNC4_ENST00000412512.2_Intron|KCNC4_ENST00000413138.3_Silent_p.R516R	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	516			R -> Q (in dbSNP:rs59123361).		synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTTCCCCCCGGGACAGCACCT	0.597000													22	52					3.1745e-13	4.90205e-13	0.729181	1	0
HELB	92797	broad.mit.edu	37	12	66712429	66712429	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:66712429G>T	ENST00000247815.4	+	7	2071	c.2012G>T	c.(2011-2013)cGc>cTc	p.R671L		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	671					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		ATCTCAAGACGCCAATTTCCA	0.313000													14	36					5.35267e-07	6.76955e-07	0.557998	1	0
PHLPP1	23239	broad.mit.edu	37	18	60646012	60646012	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:60646012G>C	ENST00000400316.4	+	17	4747	c.2966G>C	c.(2965-2967)gGa>gCa	p.G989A	PHLPP1_ENST00000262719.5_Missense_Mutation_p.G1501A	NM_194449.3	NP_919431.2	O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	1501					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						CCCCCGCCCGGAGCCCTAAGC	0.632000													3	9					0	0	0.115264	0	0
LECT2	3950	broad.mit.edu	37	5	135283148	135283148	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:135283148A>T	ENST00000274507.1	-	4	528	c.328T>A	c.(328-330)Tat>Aat	p.Y110N	FBXL21_ENST00000467490.1_RNA|LECT2_ENST00000471827.1_Intron|LECT2_ENST00000512872.1_Missense_Mutation_p.Y38N|LECT2_ENST00000522943.1_Intron	NM_002302.2	NP_002293.2	O14960	LECT2_HUMAN	leukocyte cell-derived chemotaxin 2	110					chemotaxis|skeletal system development	cytoplasm|extracellular space				large_intestine(1)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGACCTTTATACTTAATTGGC	0.318000													8	20					0	0	0.307466	0	0
TSIX	9383	broad.mit.edu	37	X	73046552	73046552	+	RNA	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:73046552C>G	ENST00000604411.1	+	0	34513				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CTCCAGATTCCGGCCGTTAGT	0.507000													27	51					0	0	0.740014	0	0
AHCTF1	25909	broad.mit.edu	37	1	247068885	247068885	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:247068885C>G	ENST00000366508.1	-	6	1080	c.944G>C	c.(943-945)cGg>cCg	p.R315P	AHCTF1_ENST00000326225.3_Missense_Mutation_p.R289P|AHCTF1_ENST00000391829.2_Missense_Mutation_p.R280P			Q8WYP5	ELYS_HUMAN	AT hook containing transcription factor 1	280	Necessary for cytoplasmic localization (By similarity).				cytokinesis|mitotic prometaphase|mRNA transport|nuclear pore complex assembly|protein transport|transmembrane transport	condensed chromosome kinetochore|cytosol|nuclear matrix|nuclear membrane|nuclear pore|nucleoplasm	DNA binding			NS(1)|breast(6)|cervix(3)|endometrium(8)|kidney(6)|large_intestine(12)|liver(2)|lung(21)|ovary(5)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	74	all_cancers(71;3.05e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00271)			ACAGCAATTCCGAGGATCATT	0.353000													22	77					0	0	0.706142	0	0
KCND2	3751	broad.mit.edu	37	7	119915700	119915700	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:119915700C>T	ENST00000331113.4	+	1	1979	c.1014C>T	c.(1012-1014)ttC>ttT	p.F338F		NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	338					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TCATCATCTTCGCTACAGTTA	0.517000													6	84					0	0	0.248553	0	0
PLCE1	51196	broad.mit.edu	37	10	95987179	95987179	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:95987179C>A	ENST00000260766.3	+	5	2560	c.1926C>A	c.(1924-1926)aaC>aaA	p.N642K	PLCE1_ENST00000371380.2_Missense_Mutation_p.N642K|PLCE1_ENST00000371375.1_Missense_Mutation_p.N334K|PLCE1_ENST00000371385.3_Missense_Mutation_p.N334K	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	642	Ras-GEF.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				GCAACTACAACGCTGTCATGG	0.488000													12	135					1.02788e-11	1.48857e-11	0.520397	1	0
HID1	283987	broad.mit.edu	37	17	72955008	72955008	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:72955008T>A	ENST00000425042.2	-	9	1224	c.1147A>T	c.(1147-1149)Aag>Tag	p.K383*		NM_030630.2	NP_085133.1			HID1 domain containing																		TGGCCCACCTTGTTGAAGTCG	0.617000											OREG0024721	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	18					0	0	0.361761	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84606548	84606548	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:84606548C>A	ENST00000344803.2	+	4	1210	c.1163C>A	c.(1162-1164)gCc>gAc	p.A388D		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TCTTCTGAGGCCTTTTTAGGG	0.468000													6	20					0.00198382	0.00214498	0.248553	1	0
HAS2	3037	broad.mit.edu	37	8	122627197	122627197	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:122627197G>T	ENST00000303924.4	-	4	1348	c.811C>A	c.(811-813)Cag>Aag	p.Q271K		NM_005328.2	NP_005319.1	Q92819	HAS2_HUMAN	hyaluronan synthase 2	271						integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(19)|ovary(5)|skin(1)	38	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			AAATAAGACTGACAGGCCCTT	0.383000													31	46					4.31865e-32	8.07399e-32	0.804634	1	0
ZNF536	9745	broad.mit.edu	37	19	31039763	31039763	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:31039763G>A	ENST00000355537.3	+	4	3384	c.3237G>A	c.(3235-3237)atG>atA	p.M1079I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	1079					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.M1079I(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTGAGAAGATGGCCCAAGGTC	0.537000													10	19					0	0	0.361761	0	0
PSMA7	5688	broad.mit.edu	37	20	60714836	60714836	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:60714836C>T	ENST00000370858.3	-	3	475	c.349G>A	c.(349-351)Gtg>Atg	p.V117M	PSMA7_ENST00000484488.1_5'UTR|PSMA7_ENST00000370861.1_Splice_Site|PSMA7_ENST00000370873.4_Splice_Site			O14818	PSA7_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 7	122					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity			large_intestine(1)|lung(2)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CAGGCACCCACCTGCTTCAGA	0.622000													27	52					0	0	0.769981	0	0
CD163L1	283316	broad.mit.edu	37	12	7586288	7586288	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:7586288C>A	ENST00000313599.3	-	3	184	c.127G>T	c.(127-129)Gga>Tga	p.G43*	CD163L1_ENST00000416109.2_Nonsense_Mutation_p.G43*|CD163L1_ENST00000396630.1_Nonsense_Mutation_p.G43*			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	43						extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						AAATCTGTTCCATCTGCAAGA	0.438000													38	79					6.5261e-18	1.11222e-17	0.840704	1	0
TRIM51HP	440041	broad.mit.edu	37	11	55062962	55062962	+	RNA	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:55062962G>T	ENST00000526016.1	-	0	675					NR_038174.2																						TCTGCTTTATGGCACATTTTC	0.443000													15	37					2.4624e-09	3.30885e-09	0.575678	1	0
TTN	7273	broad.mit.edu	37	2	179438168	179438168	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:179438168C>A	ENST00000589042.1	-	326	72915	c.72691G>T	c.(72691-72693)Gtg>Ttg	p.V24231L	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.V15291L|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.V15358L|TTN_ENST00000591111.1_Missense_Mutation_p.V22590L|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.V21663L|TTN_ENST00000460472.2_Missense_Mutation_p.V15166L|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000592600.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22590	Ig-like 121.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGTTGTCACTTCAGGGTTT	0.453000													19	77					1.10513e-12	1.67872e-12	0.624587	1	0
SLC2A5	6518	broad.mit.edu	37	1	9107740	9107740	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:9107740A>C	ENST00000377424.4	-	4	526	c.347T>G	c.(346-348)aTg>aGg	p.M116R	SLC2A5_ENST00000377414.3_Missense_Mutation_p.M116R|SLC2A5_ENST00000536305.1_Missense_Mutation_p.M57R|SLC2A5_ENST00000535586.1_Start_Codon_SNP_p.M1R	NM_003039.2	NP_003030.1	P22732	GTR5_HUMAN	solute carrier family 2 (facilitated glucose/fructose transporter), member 5	116					carbohydrate metabolic process	integral to membrane|plasma membrane	fructose transmembrane transporter activity|glucose transmembrane transporter activity			endometrium(6)|kidney(15)|large_intestine(6)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|urinary_tract(1)	36	Ovarian(185;0.112)|all_lung(157;0.185)	all_epithelial(116;1.34e-15)|all_lung(118;9.46e-05)|Lung NSC(185;0.000172)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.00715)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;7.78e-07)|COAD - Colon adenocarcinoma(227;8.83e-05)|Kidney(185;0.000286)|KIRC - Kidney renal clear cell carcinoma(229;0.00103)|STAD - Stomach adenocarcinoma(132;0.0019)|BRCA - Breast invasive adenocarcinoma(304;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGCATCCCATTAAGATCGC	0.408000													9	69					0	0	0.307466	0	0
PRG4	10216	broad.mit.edu	37	1	186275983	186275983	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:186275983C>A	ENST00000445192.2	+	7	1177	c.1132C>A	c.(1132-1134)Ccc>Acc	p.P378T	PRG4_ENST00000367484.3_Missense_Mutation_p.P337T|PRG4_ENST00000367485.4_Missense_Mutation_p.P285T|PRG4_ENST00000367483.4_Missense_Mutation_p.P337T|PRG4_ENST00000367486.3_Missense_Mutation_p.P335T	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	378	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						ACCCACCACCCCCAAGGAGCC	0.637000													6	137					5.9392e-07	7.4607e-07	0.217242	1	0
MAOA	4128	broad.mit.edu	37	X	43515603	43515603	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:43515603A>G	ENST00000338702.3	+	1	137	c.14A>G	c.(13-15)gAg>gGg	p.E5G	MAOA_ENST00000497485.1_3'UTR|MAOA_ENST00000542639.1_5'UTR	NM_000240.3	NP_000231.1	P21397	AOFA_HUMAN	monoamine oxidase A	5					behavior|neurotransmitter biosynthetic process|neurotransmitter catabolic process|neurotransmitter secretion|xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	primary amine oxidase activity|protein binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	18					Almotriptan(DB00918)|Carbidopa(DB00190)|Clonazepam(DB01068)|Dopamine(DB00988)|Fluvoxamine(DB00176)|Ginkgo biloba(DB01381)|Imipramine(DB00458)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Linezolid(DB00601)|Lorazepam(DB00186)|Moclobemide(DB01171)|Nicotine(DB00184)|Norepinephrine(DB00368)|Phenelzine(DB00780)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Pseudoephedrine(DB00852)|Rasagiline(DB01367)|Riboflavin(DB00140)|Rizatriptan(DB00953)|Selegiline(DB01037)|Sumatriptan(DB00669)|Testosterone(DB00624)|Tranylcypromine(DB00752)|Zolmitriptan(DB00315)	GAGAATCAAGAGAAGGCGAGT	0.612000													3	74					0	0	0.184627	0	0
SYT1	6857	broad.mit.edu	37	12	79689996	79689996	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:79689996A>C	ENST00000261205.4	+	7	1279	c.622A>C	c.(622-624)Aat>Cat	p.N208H	SYT1_ENST00000457153.2_Missense_Mutation_p.N205H|SYT1_ENST00000552744.1_Missense_Mutation_p.N208H|SYT1_ENST00000393240.3_Missense_Mutation_p.N208H	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	208	C2 1.|Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						TCCTGTCTTCAATGAGCAATT	0.358000													9	29					0	0	0.361761	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33546166	33546166	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:33546166G>T	ENST00000504830.1	-	22	4779	c.4444C>A	c.(4444-4446)Ctg>Atg	p.L1482M	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.L1397M	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	1482	TSP type-1 8.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						AGTCTTACCAGGTCCCAGTTC	0.433000										HNSCC(64;0.19)			17	44					1.66031e-10	2.2973e-10	0.667858	1	0
CTNNA2	1496	broad.mit.edu	37	2	80782913	80782913	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:80782913C>T	ENST00000466387.1	+	16	2360	c.1636C>T	c.(1636-1638)Cgg>Tgg	p.R546W	CTNNA2_ENST00000361291.4_Missense_Mutation_p.R580W|CTNNA2_ENST00000541047.1_Missense_Mutation_p.R546W|CTNNA2_ENST00000402739.4_Missense_Mutation_p.R546W|CTNNA2_ENST00000540488.1_Missense_Mutation_p.R546W|CTNNA2_ENST00000496558.1_Missense_Mutation_p.R546W|CTNNA2_ENST00000343114.3_Missense_Mutation_p.R225W			P26232	CTNA2_HUMAN	catenin (cadherin-associated protein), alpha 2	546					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(49)|pancreas(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	78						CATCAGGGGCCGGGCAGCTCG	0.498000													28	66					0	0	0.717897	0	0
MAGEC2	51438	broad.mit.edu	37	X	141290746	141290746	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:141290746C>A	ENST00000247452.3	-	3	1375	c.1028G>T	c.(1027-1029)aGa>aTa	p.R343I		NM_016249.3	NP_057333.1	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	343						cytoplasm|nucleus				NS(2)|breast(3)|endometrium(3)|kidney(2)|large_intestine(8)|lung(18)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(3)	47	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCTGGACTCTCTCTTCCAC	0.453000										HNSCC(46;0.14)			12	166					0.0285812	0.0298634	0.500413	1	0
GSG1	83445	broad.mit.edu	37	12	13243747	13243747	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:13243747C>T	ENST00000337630.6	-	2	82	c.15G>A	c.(13-15)gaG>gaA	p.E5E	GSG1_ENST00000537302.1_Silent_p.E5E|GSG1_ENST00000324458.8_Silent_p.E18E|GSG1_ENST00000432710.2_Silent_p.E18E|GSG1_ENST00000457134.2_Silent_p.E5E|GSG1_ENST00000351606.6_Silent_p.E18E|GSG1_ENST00000396310.2_Silent_p.E2E|GSG1_ENST00000396302.3_Silent_p.E5E	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	5						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		CCTTCGAGAGCTCCATCTGTA	0.567000													12	33					0	0	0.479597	0	0
COBL	23242	broad.mit.edu	37	7	51095939	51095939	+	Missense_Mutation	SNP	C	C	T	rs139783292		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:51095939C>T	ENST00000395542.2	-	12	3284	c.3100G>A	c.(3100-3102)Ggg>Agg	p.G1034R	COBL_ENST00000265136.7_Missense_Mutation_p.G952R			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	952										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					ATGACCTCCCCCCTAGGAGGG	0.567000													18	50					0	0	0.681144	0	0
COG6	57511	broad.mit.edu	37	13	40297470	40297470	+	Splice_Site	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:40297470A>T	ENST00000416691.1	+	16	1685	c.1584_splice	c.e16-1	p.I529_splice	COG6_ENST00000455146.3_Splice_Site_p.I529_splice	NM_001145079.1	NP_001138551.1	Q9Y2V7	COG6_HUMAN	component of oligomeric golgi complex 6	529					protein transport	Golgi membrane|Golgi transport complex				NS(1)|kidney(2)|large_intestine(5)|lung(4)|skin(1)	13		Lung NSC(96;0.000124)|Breast(139;0.0199)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.03e-09)|Epithelial(112;7e-07)|OV - Ovarian serous cystadenocarcinoma(117;0.00015)|BRCA - Breast invasive adenocarcinoma(63;0.00438)|GBM - Glioblastoma multiforme(144;0.0168)		TTTATTTTAGATCGAAGCACA	0.378000													6	18					0	0	0.217242	0	0
KRTAP5-7	440050	broad.mit.edu	37	11	71238382	71238382	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:71238382C>T	ENST00000398536.4	+	1	70	c.36C>T	c.(34-36)tcC>tcT	p.S12S		NM_001012503.1	NP_001012521.1	Q6L8G8	KRA57_HUMAN	keratin associated protein 5-7	12						keratin filament				breast(1)|endometrium(1)|kidney(3)|lung(6)|ovary(1)	12						GCTGTGGCTCCGGCTGTGGGG	0.662000													39	208					0	0	0.864702	0	0
PLBD2	196463	broad.mit.edu	37	12	113826320	113826320	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:113826320G>T	ENST00000280800.3	+	12	1690	c.1659G>T	c.(1657-1659)acG>acT	p.T553T	PLBD2_ENST00000545182.2_Silent_p.T521T	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	553					lipid catabolic process	lysosomal lumen	hydrolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						GCGGTCCCACGTGGGACCAGG	0.677000													5	13					0.000602214	0.000665292	0.184627	1	0
PDE6A	5145	broad.mit.edu	37	5	149276334	149276334	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:149276334G>T	ENST00000255266.5	-	11	1532	c.1413C>A	c.(1411-1413)acC>acA	p.T471T		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	471					cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			ACACCTCTCTGGTTTTCTGCC	0.522000													27	119					1.36615e-20	2.37905e-20	0.769981	1	0
CDH9	1007	broad.mit.edu	37	5	26885905	26885905	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:26885905G>T	ENST00000231021.4	-	11	1872	c.1700C>A	c.(1699-1701)cCg>cAg	p.P567Q		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	567	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P567L(1)		breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						GATTAAAATCGGCAATAAGTA	0.408000													15	24					1.02788e-11	1.48857e-11	0.520397	1	0
DNAJB9	4189	broad.mit.edu	37	7	108213735	108213735	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:108213735A>T	ENST00000249356.3	+	3	1156	c.610A>T	c.(610-612)Agg>Tgg	p.R204W	DNAJB9_ENST00000465725.1_Intron	NM_012328.2	NP_036460.1	Q9UBS3	DNJB9_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 9	204					ER-associated protein catabolic process|protein folding	endoplasmic reticulum|nucleolus	heat shock protein binding|misfolded protein binding|unfolded protein binding			central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|urinary_tract(1)	13						CAAGCACTGCAGGACTGTCAC	0.378000													31	81					0	0	0.804634	0	0
GRIP2	80852	broad.mit.edu	37	3	14559366	14559366	+	RNA	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:14559366G>A	ENST00000273083.3	-	0	1134							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						GGGCACGCAGGGGTCCCAGCG	0.642000													4	7					0	0	0.184627	0	0
FAM154B	283726	broad.mit.edu	37	15	82575098	82575098	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:82575098G>A	ENST00000339465.5	+	3	961	c.892G>A	c.(892-894)Gga>Aga	p.G298R	FAM154B_ENST00000565501.1_3'UTR|FAM154B_ENST00000427381.2_Missense_Mutation_p.G283R	NM_001008226.1	NP_001008227.1	Q658L1	F154B_HUMAN	family with sequence similarity 154, member B	298										autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)	19						TTGTCGTCAAGGACTTATTAA	0.403000													14	36					0	0	0.592651	0	0
NEFM	4741	broad.mit.edu	37	8	24775285	24775285	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:24775285C>A	ENST00000221166.5	+	3	2699	c.1917C>A	c.(1915-1917)ggC>ggA	p.G639G	NEFM_ENST00000433454.2_Silent_p.G263G|NEFM_ENST00000521540.1_Intron|NEFM_ENST00000437366.2_Intron|NEFM_ENST00000518131.1_Intron			P07197	NFM_HUMAN	neurofilament, medium polypeptide	639	6 X 13 AA approximate tandem repeats of K-S-P-V-[PS]-K-S-P-V-E-E-[KA]-[GAK].|Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		AAGAGAAAGGCAAGTCTCCTG	0.502000													25	82					9.78306e-22	1.73611e-21	0.740014	1	0
SRBD1	55133	broad.mit.edu	37	2	45829187	45829187	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:45829187C>A	ENST00000263736.4	-	3	178	c.116G>T	c.(115-117)aGt>aTt	p.S39I		NM_018079.4	NP_060549.4	Q8N5C6	SRBD1_HUMAN	S1 RNA binding domain 1	39					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		hydrolase activity, acting on ester bonds|RNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(13)|large_intestine(8)|lung(15)|skin(2)|stomach(1)|urinary_tract(1)	49		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)	LUSC - Lung squamous cell carcinoma(58;0.0917)|Lung(47;0.154)			CTCCCAGGCACTATCTTCCTT	0.443000													22	37					6.36457e-07	7.97712e-07	0.667858	1	0
STK11	6794	broad.mit.edu	37	19	1207078	1207078	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:1207078G>T	ENST00000326873.7	+	1	1339	c.166G>T	c.(166-168)Ggg>Tgg	p.G56W	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	56	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.G56W(2)|p.G56fs*107(1)|p.G56fs*4(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GGACCTGCTGGGGGAAGGCTC	0.612000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			16	20					7.45023e-12	1.09309e-11	0.592651	1	0
RYR3	6263	broad.mit.edu	37	15	33895372	33895372	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:33895372C>A	ENST00000389232.4	+	18	2041	c.1971C>A	c.(1969-1971)taC>taA	p.Y657*	RYR3_ENST00000415757.3_Nonsense_Mutation_p.Y657*	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	657	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGCCCAGTACAAGAAGTGGT	0.537000													16	71					6.94344e-10	9.48994e-10	0.539581	1	0
CDH12	1010	broad.mit.edu	37	5	21755941	21755941	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:21755941C>A	ENST00000382254.1	-	14	2730	c.1644G>T	c.(1642-1644)gcG>gcT	p.A548A	CDH12_ENST00000521384.1_5'UTR|RP11-804N13.1_ENST00000522350.1_RNA|CDH12_ENST00000504376.2_Silent_p.A548A|CDH12_ENST00000522262.1_Silent_p.A508A	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	548	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A548A(1)		NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						TTTCAATCCCCGCTGTGTTGT	0.428000										HNSCC(59;0.17)			13	52					0.00498961	0.00533306	0.520397	1	0
CNTN4	152330	broad.mit.edu	37	3	2777967	2777967	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:2777967G>A	ENST00000397461.1	+	4	508	c.124G>A	c.(124-126)Gag>Aag	p.E42K	CNTN4_ENST00000418658.1_Missense_Mutation_p.E42K|CNTN4_ENST00000427331.1_Missense_Mutation_p.E42K	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	42	Ig-like C2-type 1.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TTTGGATTCTGAGGAGAAAAA	0.363000													21	69					0	0	0.592651	0	0
GJA8	2703	broad.mit.edu	37	1	147380414	147380414	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:147380414C>T	ENST00000240986.4	+	2	385	c.332C>T	c.(331-333)gCg>gTg	p.A111V	GJA8_ENST00000369235.1_Missense_Mutation_p.A111V	NM_005267.4	NP_005258.2	P48165	CXA8_HUMAN	gap junction protein, alpha 8, 50kDa	111				EA -> D (in Ref. 1; AAA77062).	cell communication|visual perception	connexon complex|integral to plasma membrane	channel activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)	37	all_hematologic(923;0.0276)					AGCCGCGAGGCGGAGGAGCTG	0.652000													10	45					0	0	0.411799	0	0
ADAM7	8756	broad.mit.edu	37	8	24365030	24365030	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:24365030C>A	ENST00000175238.6	+	21	2329	c.2246C>A	c.(2245-2247)cCc>cAc	p.P749H	RP11-624C23.1_ENST00000523578.1_RNA|ADAM7_ENST00000520720.1_Intron|ADAM7_ENST00000380789.1_Missense_Mutation_p.P771H|RP11-561E1.1_ENST00000519364.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	749					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ATCGCAGATCCCAATCAAAGT	0.383000													22	69					9.04412e-07	1.12348e-06	0.681144	1	0
AEBP1	165	broad.mit.edu	37	7	44152247	44152247	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:44152247T>A	ENST00000223357.3	+	18	2613	c.2308T>A	c.(2308-2310)Tcc>Acc	p.S770T	AEBP1_ENST00000450684.2_Missense_Mutation_p.S345T	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	770	Interaction with PTEN (By similarity).				cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						GCGGCTAGTATCCTACCCCTA	0.652000													10	60					0	0	0.411799	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104984579	104984579	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:104984579G>C	ENST00000372582.1	+	8	1699	c.943G>C	c.(943-945)Gca>Cca	p.A315P	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.A315P	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	315	Ig-like C2-type 3.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						AGTTGAATTGGCACTCATCTT	0.443000													8	65					0	0	0.307466	0	0
LPPR4	9890	broad.mit.edu	37	1	99767302	99767302	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:99767302C>T	ENST00000370185.3	+	6	1312	c.815C>T	c.(814-816)aCg>aTg	p.T272M	LPPR4_ENST00000370184.1_Missense_Mutation_p.T114M|LPPR4_ENST00000457765.1_Intron	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		272							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TCCACATTAACGGATTCCTCT	0.333000													7	22					0	0	0.307466	0	0
SYNPO2	171024	broad.mit.edu	37	4	119952569	119952569	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:119952569A>T	ENST00000307142.4	+	4	2835	c.2639A>T	c.(2638-2640)cAg>cTg	p.Q880L	SYNPO2_ENST00000429713.2_Missense_Mutation_p.Q880L|SYNPO2_ENST00000448416.2_Intron|SYNPO2_ENST00000434046.2_Missense_Mutation_p.Q880L	NM_133477.2	NP_597734.2	Q9UMS6	SYNP2_HUMAN	synaptopodin 2	880						nucleus|Z disc	14-3-3 protein binding|actin binding|muscle alpha-actinin binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(18)|ovary(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCTAAAAGGCAGTCGAGAATG	0.552000													9	79					0	0	0.335167	0	0
ZNF597	146434	broad.mit.edu	37	16	3493134	3493134	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr16:3493134G>A	ENST00000301744.4	-	2	255	c.20C>T	c.(19-21)aCg>aTg	p.T7M	LA16c-306E5.2_ENST00000575785.1_RNA	NM_152457.1	NP_689670.1	Q96LX8	ZN597_HUMAN	zinc finger protein 597	7					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)|urinary_tract(1)	13						GGCCTCGGGCGTCGGGGGCAT	0.582000													16	41					0	0	0.608945	0	0
GUCY2F	2986	broad.mit.edu	37	X	108697069	108697069	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:108697069G>T	ENST00000218006.2	-	4	1343	c.1052C>A	c.(1051-1053)aCc>aAc	p.T351N		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	351					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						ATTGTAGATGGTTCCAAACAA	0.408000													4	18					0.00909568	0.00962971	0.150653	1	0
DRD5	1816	broad.mit.edu	37	4	9784506	9784506	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:9784506C>A	ENST00000304374.2	+	1	1249	c.853C>A	c.(853-855)Cgc>Agc	p.R285S		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	285					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CACCAGCCTGCGCGCTTCCAT	0.627000													5	12					2.7689e-08	3.6678e-08	0.248553	1	0
HCN1	348980	broad.mit.edu	37	5	45262384	45262384	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:45262384G>T	ENST00000303230.4	-	8	2369	c.2312C>A	c.(2311-2313)aCg>aAg	p.T771K		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	771						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						AAGCGCCTGCGTGCTCTTGTG	0.632000													21	24					1.04121e-07	1.35673e-07	0.693898	1	0
SLC16A14	151473	broad.mit.edu	37	2	230914552	230914552	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:230914552T>A	ENST00000295190.4	-	3	786	c.328A>T	c.(328-330)Aac>Tac	p.N110Y		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	110						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		CCCAGGGAGTTGACGAGCCCT	0.488000													40	86					0	0	0.870114	0	0
CCDC63	160762	broad.mit.edu	37	12	111342463	111342463	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:111342463G>C	ENST00000308208.5	+	11	1656	c.1414G>C	c.(1414-1416)Gca>Cca	p.A472P	CCDC63_ENST00000552694.1_Missense_Mutation_p.A393P|CCDC63_ENST00000545036.1_Missense_Mutation_p.A432P	NM_152591.1	NP_689804.1	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	472										NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(1)	39						AGTGGAAGGGGCAGAGGCTGA	0.577000													12	56					0	0	0.411799	0	0
SLC24A2	25769	broad.mit.edu	37	9	19786265	19786265	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:19786265G>T	ENST00000341998.2	-	1	661	c.600C>A	c.(598-600)caC>caA	p.H200Q	SLC24A2_ENST00000286344.3_Missense_Mutation_p.H200Q	NM_001193288.2|NM_020344.3	NP_001180217.1|NP_065077.1	Q9UI40	NCKX2_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 2	200					visual perception	integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33				GBM - Glioblastoma multiforme(1;1.67e-55)|Lung(42;0.0443)		CAACGTTGCTGTGAGCGATAA	0.463000													8	55					0.000442599	0.000492855	0.335167	1	0
ARMCX2	9823	broad.mit.edu	37	X	100911063	100911063	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:100911063G>T	ENST00000328766.5	-	5	1965	c.1512C>A	c.(1510-1512)caC>caA	p.H504Q	ARMCX2_ENST00000356824.4_Missense_Mutation_p.H504Q|ARMCX2_ENST00000330154.2_Missense_Mutation_p.H504Q	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	504						integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						TGACAAGCAGGTGCTGGTAGT	0.373000													19	130					9.95505e-16	1.59452e-15	0.624587	1	0
KIAA1549L	25758	broad.mit.edu	37	11	33566894	33566894	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:33566894C>A	ENST00000321505.4	+	2	2644	c.2464C>A	c.(2464-2466)Cag>Aag	p.Q822K	KIAA1549L_ENST00000265654.5_Missense_Mutation_p.Q828K|KIAA1549L_ENST00000389726.3_Missense_Mutation_p.Q828K					KIAA1549-like																		CCTGGAGTGTCAGATGTCCAG	0.502000													6	12					5.9392e-07	7.4607e-07	0.217242	1	0
GPR112	139378	broad.mit.edu	37	X	135427278	135427278	+	Silent	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:135427278T>A	ENST00000394143.1	+	6	1704	c.1413T>A	c.(1411-1413)ccT>ccA	p.P471P	GPR112_ENST00000394141.1_Silent_p.P266P|GPR112_ENST00000412101.1_Silent_p.P266P|GPR112_ENST00000370652.1_Silent_p.P471P|GPR112_ENST00000287534.4_Silent_p.P408P	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	471					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P471P(1)		NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CACCTGAGCCTGTGCTCATCT	0.448000													7	73					0	0	0.307466	0	0
PCDH17	27253	broad.mit.edu	37	13	58299242	58299242	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:58299242G>T	ENST00000377918.3	+	4	3320	c.3294G>T	c.(3292-3294)agG>agT	p.R1098S		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1098					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		AGATGGCAAGGGTCTTTGCAG	0.532000													27	145					7.11191e-15	1.11987e-14	0.769981	1	0
FIP1L1	81608	broad.mit.edu	37	4	54324957	54324957	+	Splice_Site	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:54324957G>T	ENST00000337488.6	+	17	1831	c.1637_splice	c.e17+1	p.S546_splice	FIP1L1_ENST00000358575.5_Splice_Site_p.S540_splice|FIP1L1_ENST00000306932.6_Splice_Site_p.S472_splice|FIP1L1_ENST00000507166.1_Intron	NM_030917.3	NP_112179.2	Q6UN15	FIP1_HUMAN	factor interacting with PAPOLA and CPSF1	546	Arg-rich.|Glu-rich.|Sufficient for interaction with CPSF1 and CSTF3.				mRNA processing	nucleus	RNA binding			large_intestine(3)|liver(1)|ovary(1)|skin(1)	6			GBM - Glioblastoma multiforme(3;3.31e-36)|LUSC - Lung squamous cell carcinoma(32;0.0134)			TCTTCTCGAAGGTTTGCTCTT	0.403000			T	PDGFRA	idiopathic hypereosinophilic syndrome								6	11					0.00448238	0.00482784	0.307466	1	0
MAB21L2	10586	broad.mit.edu	37	4	151504255	151504255	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:151504255C>A	ENST00000317605.4	+	1	1179	c.74C>A	c.(73-75)gCg>gAg	p.A25E	LRBA_ENST00000510413.1_Intron|LRBA_ENST00000535741.1_Intron|LRBA_ENST00000507224.1_Intron|LRBA_ENST00000357115.3_Intron	NM_006439.4	NP_006430.1	Q9Y586	MB212_HUMAN	mab-21-like 2 (C. elegans)	25					nervous system development	nucleus				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(2)	21	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		GCGCGCAAGGCGGCCATCGCC	0.587000													5	21					0.0215528	0.0225618	0.217242	1	0
DLK1	8788	broad.mit.edu	37	14	101201086	101201086	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:101201086C>A	ENST00000341267.4	+	5	1247	c.1005C>A	c.(1003-1005)tcC>tcA	p.S335S	DLK1_ENST00000331224.6_Silent_p.S262S	NM_003836.5	NP_003827.3	P80370	DLK1_HUMAN	delta-like 1 homolog (Drosophila)	335					multicellular organismal development	extracellular space|integral to membrane|soluble fraction				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(16)|ovary(2)|prostate(1)|skin(1)	29		Melanoma(154;0.155)				CCTGGGTGTCCAACCTGCGCT	0.587000													37	90					3.21987e-24	5.86289e-24	0.870114	1	0
MTFP1	51537	broad.mit.edu	37	22	30824457	30824457	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:30824457A>T	ENST00000439838.1	+	9	953	c.953A>T	c.(952-954)gAt>gTt	p.D318V	MTFP1_ENST00000407550.3_Missense_Mutation_p.D123V|MTFP1_ENST00000355143.4_Silent_p.G68G|MTFP1_ENST00000266263.5_Missense_Mutation_p.D146V																							AGGTCGGTGGATTTCCTCCTG	0.592000													6	38					0	0	0.335167	0	0
TENM2	57451	broad.mit.edu	37	5	167671538	167671538	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:167671538C>A	ENST00000519204.1	+	25	5389	c.5271C>A	c.(5269-5271)cgC>cgA	p.R1757R	TENM2_ENST00000518659.1_Silent_p.R1878R|TENM2_ENST00000545108.1_Silent_p.R1877R|TENM2_ENST00000520394.1_Silent_p.R1639R|TENM2_ENST00000403607.2_Silent_p.R1702R					teneurin transmembrane protein 2																		AGGTGGGCCGCCCCTTCCTCT	0.547000													10	51					0.000151284	0.000172588	0.435327	1	0
NAV3	89795	broad.mit.edu	37	12	78513500	78513500	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:78513500C>A	ENST00000397909.2	+	15	3697	c.3524C>A	c.(3523-3525)aCc>aAc	p.T1175N	NAV3_ENST00000266692.7_Missense_Mutation_p.T1175N|NAV3_ENST00000536525.2_Missense_Mutation_p.T1175N|NAV3_ENST00000228327.6_Missense_Mutation_p.T1175N			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1175	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GGGGCCACCACCTCGAAACTG	0.517000										HNSCC(70;0.22)			10	32					0.00829132	0.00882828	0.361761	1	0
OR5B21	219968	broad.mit.edu	37	11	58275359	58275359	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:58275359C>A	ENST00000360374.2	-	1	219	c.220G>T	c.(220-222)Gct>Tct	p.A74S		NM_001005218.1	NP_001005218.1	A6NL26	OR5BL_HUMAN	olfactory receptor, family 5, subfamily B, member 21	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGGGCTACAGCTGATGAGTAA	0.517000													19	33					3.5997e-14	5.6365e-14	0.624587	1	0
HGF	3082	broad.mit.edu	37	7	81355295	81355295	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:81355295G>T	ENST00000222390.5	-	9	1305	c.1079C>A	c.(1078-1080)tCt>tAt	p.S360Y	HGF_ENST00000457544.2_Missense_Mutation_p.S355Y	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	360	Kringle 3.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						GGGTGATTCAGACCCATCTGG	0.438000													33	67					1.69901e-12	2.55308e-12	0.812448	1	0
TTN	7273	broad.mit.edu	37	2	179566271	179566271	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:179566271T>A	ENST00000589042.1	-	110	30806	c.30582A>T	c.(30580-30582)agA>agT	p.R10194S	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.R9877S|TTN_ENST00000342992.6_Missense_Mutation_p.R8950S|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589830.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9877	Glu-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGCACTGCTCTGATAGGCA	0.433000													39	64					0	0	0.870114	0	0
ZNF280B	140883	broad.mit.edu	37	22	22842827	22842827	+	Silent	SNP	C	C	A	rs148287160		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:22842827C>A	ENST00000360412.2	-	4	1672	c.897G>T	c.(895-897)ccG>ccT	p.P299P	ZNF280B_ENST00000406426.1_Silent_p.P299P	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		TCTTCTGTTCCGGCTGCCCTT	0.388000													12	60					1.49906e-05	1.76416e-05	0.457914	1	0
ITGB7	3695	broad.mit.edu	37	12	53587597	53587597	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr12:53587597A>T	ENST00000267082.5	-	11	1628	c.1397T>A	c.(1396-1398)cTg>cAg	p.L466Q	ITGB7_ENST00000422257.3_Missense_Mutation_p.L466Q|ITGB7_ENST00000550743.2_Missense_Mutation_p.L466Q|ITGB7_ENST00000338737.4_Missense_Mutation_p.L466Q	NM_000889.1	NP_000880.1	P26010	ITB7_HUMAN	integrin, beta 7	466					cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|regulation of immune response	integrin complex	identical protein binding|metal ion binding|receptor activity			NS(2)|breast(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CTCCACAATCAGCTCCTCTGA	0.587000													13	35					0	0	0.520397	0	0
ANGPT1	284	broad.mit.edu	37	8	108315533	108315533	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:108315533G>T	ENST00000520734.1	-	4	556	c.271C>A	c.(271-273)Caa>Aaa	p.Q91K	ANGPT1_ENST00000520052.1_Missense_Mutation_p.Q90K|ANGPT1_ENST00000518386.1_Intron			Q15389	ANGP1_HUMAN	angiopoietin 1	291					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			AAACCAGCTTGATATACATCT	0.303000													12	54					2.62699e-14	4.12496e-14	0.479597	1	0
CHL1	10752	broad.mit.edu	37	3	386357	386357	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:386357G>A	ENST00000256509.2	+	9	1455	c.813G>A	c.(811-813)ggG>ggA	p.G271G	CHL1_ENST00000397491.2_Silent_p.G255G	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	255	Ig-like C2-type 3.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TCCTCAAAGGGGAAATCTTGC	0.423000													18	86					0	0	0.667858	0	0
ELF4	2000	broad.mit.edu	37	X	129206304	129206304	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:129206304G>T	ENST00000308167.5	-	5	808	c.429C>A	c.(427-429)gcC>gcA	p.A143A	ELF4_ENST00000335997.7_Silent_p.A143A	NM_001421.3	NP_001412.1	Q99607	ELF4_HUMAN	E74-like factor 4 (ets domain transcription factor)	143	RUNX1-binding.				natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						CCCTGTTCAGGGCATCGGGCT	0.552000			T	ERG	AML								10	88					5.50884e-06	6.56597e-06	0.411799	1	0
ZP4	57829	broad.mit.edu	37	1	238053229	238053229	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:238053229C>T	ENST00000366570.4	-	3	496	c.338G>A	c.(337-339)gGc>gAc	p.G113D	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	113					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TTCAGCCGCGCCTGCTCCTTC	0.562000													58	256					0	0	0.870114	0	0
TRPM4	54795	broad.mit.edu	37	19	49671235	49671235	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:49671235G>T	ENST00000252826.5	+	4	455	c.329G>T	c.(328-330)tGg>tTg	p.W110L	TRPM4_ENST00000427978.2_Missense_Mutation_p.W110L|TRPM4_ENST00000355712.5_Intron	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	110					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		ACACGCACATGGGGCTTCCGT	0.662000													33	201					3.86236e-30	7.19687e-30	0.870114	1	0
HAUS7	55559	broad.mit.edu	37	X	152721789	152721789	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:152721789C>A	ENST00000421080.2	-	9	1418	c.252G>T	c.(250-252)gaG>gaT	p.E84D	HAUS7_ENST00000370211.4_Missense_Mutation_p.E213D|TREX2_ENST00000338525.2_5'UTR|HAUS7_ENST00000370212.3_Missense_Mutation_p.E223D|TREX2_ENST00000370232.1_5'UTR|TREX2_ENST00000330912.2_5'UTR|HAUS7_ENST00000370219.3_Missense_Mutation_p.E223D|HAUS7_ENST00000484394.1_5'UTR|TREX2_ENST00000334497.2_5'UTR			Q99871	HAUS7_HUMAN	HAUS augmin-like complex, subunit 7	223					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|nucleolus|plasma membrane|spindle	thioesterase binding			endometrium(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|skin(3)	19						CCGCCAGCTTCTCCTCCTCCT	0.612000													6	106					0.00198382	0.00214498	0.248553	1	0
COL6A6	131873	broad.mit.edu	37	3	130285792	130285792	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:130285792G>C	ENST00000358511.6	+	4	1560	c.1529G>C	c.(1528-1530)gGt>gCt	p.G510A	COL6A6_ENST00000453409.2_Missense_Mutation_p.G510A	NM_001102608.1	NP_001096078.1	A6NMZ7	CO6A6_HUMAN	collagen, type VI, alpha 6	510	Nonhelical region.|VWFA 3.				axon guidance|cell adhesion	collagen				NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(30)|lung(57)|ovary(8)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	134						AGGCAGATGGGTGGGAATACA	0.458000													4	42					0	0	0.150653	0	0
MMP9	4318	broad.mit.edu	37	20	44641964	44641964	+	Silent	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:44641964C>G	ENST00000372330.3	+	9	1420	c.1401C>G	c.(1399-1401)gtC>gtG	p.V467V		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	467					collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	CCCCGACGGTCTGCCCCACCG	0.701000											OREG0025990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	73					0	0	0.624587	0	0
PRDM9	56979	broad.mit.edu	37	5	23527465	23527465	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:23527465C>A	ENST00000296682.3	+	11	2450	c.2268C>A	c.(2266-2268)ggC>ggA	p.G756G		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	756					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GTGGGCGGGGCTTTCGCGATA	0.577000										HNSCC(3;0.000094)			26	133					8.16721e-17	1.35474e-16	0.750413	1	0
SPTBN4	57731	broad.mit.edu	37	19	41029501	41029501	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:41029501T>C	ENST00000352632.3	+	17	3898	c.3812T>C	c.(3811-3813)aTc>aCc	p.I1271T	SPTBN4_ENST00000595535.1_Missense_Mutation_p.I1271T|SPTBN4_ENST00000598249.1_Missense_Mutation_p.I1271T|SPTBN4_ENST00000344104.3_Missense_Mutation_p.I1271T|SPTBN4_ENST00000338932.3_Missense_Mutation_p.I1271T			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	1271					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CAGGGCAACATCTACGGGGAG	0.627000													19	38					0	0	0.681144	0	0
HAPLN3	145864	broad.mit.edu	37	15	89422412	89422412	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:89422412C>A	ENST00000359595.3	-	4	796	c.582G>T	c.(580-582)gtG>gtT	p.V194V	HAPLN3_ENST00000562889.1_Silent_p.V256V	NM_178232.2	NP_839946.1	Q96S86	HPLN3_HUMAN	hyaluronan and proteoglycan link protein 3	194	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)	17	Lung NSC(78;0.0392)|all_lung(78;0.077)					AGGAGGCCACCACCGCAGCCT	0.642000											OREG0023445	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	39					1.12685e-05	1.33455e-05	0.307466	1	0
AGPS	8540	broad.mit.edu	37	2	178362494	178362494	+	Splice_Site	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:178362494G>T	ENST00000264167.4	+	13	1508		c.e13+1		AGPS_ENST00000409888.1_Intron	NM_003659.3	NP_003650.1	O00116	ADAS_HUMAN	alkylglycerone phosphate synthase						ether lipid biosynthetic process	peroxisomal matrix|peroxisomal membrane|plasma membrane	alkylglycerone-phosphate synthase activity|flavin adenine dinucleotide binding|oxidoreductase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0018)|Epithelial(96;0.00919)|all cancers(119;0.0358)			TATTACAAAGGTAAGAATTTT	0.299000													3	5					0.115264	0.118879	0.115264	1	0
ISL1	3670	broad.mit.edu	37	5	50683378	50683378	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:50683378C>A	ENST00000230658.7	+	3	858	c.273C>A	c.(271-273)ttC>ttA	p.F91L	ISL1_ENST00000505475.2_3'UTR|ISL1_ENST00000511384.1_Missense_Mutation_p.F91L	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	91	LIM zinc-binding 2.				generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				AGAACGACTTCGTGATGCGTG	0.632000													6	32					0.0215528	0.0225618	0.217242	1	0
OR14J1	442191	broad.mit.edu	37	6	29274875	29274875	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:29274875C>A	ENST00000377160.2	+	1	473	c.409C>A	c.(409-411)Cgt>Agt	p.R137S		NM_030946.1	NP_112208.1	Q9UGF5	O14J1_HUMAN	olfactory receptor, family 14, subfamily J, member 1	137					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(2)	17						TATGGATCCCCGTGCCTGTAG	0.507000													26	68					5.45727e-16	8.79139e-16	0.729181	1	0
SMAD4	4089	broad.mit.edu	37	18	48575062	48575062	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:48575062G>T	ENST00000342988.3	+	3	794	c.256G>T	c.(256-258)Ggt>Tgt	p.G86C	SMAD4_ENST00000398417.2_Missense_Mutation_p.G86C|SMAD4_ENST00000452201.2_Missense_Mutation_p.G86C|RP11-729L2.2_ENST00000590722.2_3'UTR|SMAD4_ENST00000588745.1_Missense_Mutation_p.G86C	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	86	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(4)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		CTAGGTGGCTGGTCGGAAAGG	0.373000													13	46					6.72482e-11	9.58974e-11	0.479597	1	0
PLAC8	51316	broad.mit.edu	37	4	84026147	84026147	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:84026147A>T	ENST00000426923.2	-	3	223	c.145T>A	c.(145-147)Tgc>Agc	p.C49S	PLAC8_ENST00000411416.2_Missense_Mutation_p.C49S|PLAC8_ENST00000311507.4_Missense_Mutation_p.C49S|PLAC8_ENST00000515389.1_Intron|PLAC8_ENST00000505406.1_Missense_Mutation_p.C49S|PLAC8_ENST00000509973.1_5'UTR	NM_001130715.1	NP_001124187.1	Q9NZF1	PLAC8_HUMAN	placenta-specific 8	49										large_intestine(2)|lung(3)|ovary(1)	6		Hepatocellular(203;0.114)				CACCCAAGGCACGGGAAACAA	0.493000													8	47					0	0	0.361761	0	0
APBB1IP	54518	broad.mit.edu	37	10	26789819	26789819	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:26789819G>T	ENST00000376236.4	+	5	687	c.232G>T	c.(232-234)Gct>Tct	p.A78S	APBB1IP_ENST00000356785.4_Missense_Mutation_p.A78S	NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	78					blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium		p.A78S(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						CATAAGTGAGGCTGAGCAGAG	0.438000													17	54					1.40151e-16	2.29749e-16	0.592651	1	0
MYH2	4620	broad.mit.edu	37	17	10428111	10428111	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:10428111G>T	ENST00000245503.5	-	34	5318	c.4934C>A	c.(4933-4935)gCc>gAc	p.A1645D	CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron|MYH2_ENST00000397183.2_Missense_Mutation_p.A1645D|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1645					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GTTCCTCAGGGCCTCAGCAGC	0.507000													26	97					2.09667e-21	3.69727e-21	0.788014	1	0
MID1	4281	broad.mit.edu	37	X	10450570	10450570	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:10450570C>T	ENST00000317552.4	-	5	1363	c.963G>A	c.(961-963)aaG>aaA	p.K321K	MID1_ENST00000380779.1_Silent_p.K321K|MID1_ENST00000380782.2_Silent_p.K321K|MID1_ENST00000380780.1_Silent_p.K321K|MID1_ENST00000380787.1_Silent_p.K321K|MID1_ENST00000380785.1_Silent_p.K321K|MID1_ENST00000453318.2_Silent_p.K321K	NM_000381.3|NM_033289.1	NP_000372.1|NP_150631.1	O15344	TRI18_HUMAN	midline 1 (Opitz/BBB syndrome)	321	COS.				microtubule cytoskeleton organization|pattern specification process|positive regulation of stress-activated MAPK cascade	cytoplasm|microtubule|microtubule associated complex|spindle	ligase activity|ubiquitin protein ligase binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	26						GATCATTCTCCTTCAGAGAGT	0.522000													11	94					0	0	0.479597	0	0
SMARCC1	6599	broad.mit.edu	37	3	47814359	47814359	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:47814359T>A	ENST00000254480.5	-	2	382	c.263A>T	c.(262-264)cAg>cTg	p.Q88L	SMARCC1_ENST00000425518.1_5'UTR	NM_003074.3	NP_003065.3	Q92922	SMRC1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	88					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(15)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	33				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		GGCATCTTCCTGGAACTGAAG	0.468000													15	42					0	0	0.520397	0	0
HTR5A	3361	broad.mit.edu	37	7	154863040	154863040	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:154863040C>A	ENST00000287907.2	+	1	1007	c.431C>A	c.(430-432)aCg>aAg	p.T144K	AC093726.4_ENST00000543018.1_5'UTR|AC093726.4_ENST00000395731.2_5'UTR|AC093726.4_ENST00000493904.1_5'UTR	NM_024012.3	NP_076917.1	P47898	5HT5A_HUMAN	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	144						integral to plasma membrane	serotonin receptor activity	p.T144M(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(3)|stomach(1)	48	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0238)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		TGGTCCATCACGCGCCACATG	0.637000													17	51					6.94344e-10	9.48994e-10	0.539581	1	0
KBTBD8	84541	broad.mit.edu	37	3	67054705	67054705	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:67054705G>T	ENST00000295568.4	+	3	1367	c.1236G>T	c.(1234-1236)gaG>gaT	p.E412D	KBTBD8_ENST00000417314.2_Missense_Mutation_p.E438D|KBTBD8_ENST00000460576.1_Intron	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	438										breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		ATGCTGTGGAGTACAAAGAGA	0.393000													40	118					4.17328e-34	7.8813e-34	0.870114	1	0
MBD5	55777	broad.mit.edu	37	2	149247298	149247298	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:149247298C>T	ENST00000407073.1	+	12	4395	c.3398C>T	c.(3397-3399)cCa>cTa	p.P1133L	MBD5_ENST00000404807.1_Missense_Mutation_p.P1366L	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1133						chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		ATTGGTGACCCATTAAATCTC	0.517000													21	83					0	0	0.693898	0	0
HERC2	8924	broad.mit.edu	37	15	28538091	28538091	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:28538091C>A	ENST00000261609.7	-	4	373	c.265G>T	c.(265-267)Gca>Tca	p.A89S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	89					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TATATAGGTGCAGGAGTTTCT	0.388000													7	9					0.0293803	0.030584	0.248553	1	0
ERMN	57471	broad.mit.edu	37	2	158177958	158177958	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:158177958G>T	ENST00000410096.1	-	3	971	c.680C>A	c.(679-681)cCa>cAa	p.P227Q	ERMN_ENST00000420719.2_Missense_Mutation_p.P207Q|ERMN_ENST00000535935.1_Missense_Mutation_p.P121Q|ERMN_ENST00000397283.2_Missense_Mutation_p.P240Q	NM_020711.1	NP_065762.1	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein	227						cytoplasm|cytoskeleton				endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12						ACTGCTCAGTGGGGAGTCCTC	0.413000													82	146					1.2711e-46	2.45016e-46	0.870114	1	0
FXYD5	53827	broad.mit.edu	37	19	35657168	35657168	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:35657168C>A	ENST00000342879.3	+	7	1205	c.427C>A	c.(427-429)Cgg>Agg	p.R143R	FXYD5_ENST00000590686.1_Silent_p.R143R|FXYD5_ENST00000588699.1_Silent_p.R143R|FXYD5_ENST00000541435.2_Silent_p.R143R|FXYD5_ENST00000543307.1_Silent_p.R143R|FXYD5_ENST00000423817.3_Silent_p.R143R|FXYD5_ENST00000392219.2_Silent_p.R143R|FXYD5_ENST00000392217.3_Silent_p.R72R|FXYD5_ENST00000591716.2_3'UTR			Q96DB9	FXYD5_HUMAN	FXYD domain containing ion transport regulator 5	143					microvillus assembly|negative regulation of calcium-dependent cell-cell adhesion	integral to membrane	actin binding|cadherin binding|ion channel activity	p.R143W(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(3)	9	all_lung(56;9.4e-09)|Lung NSC(56;1.4e-08)|Esophageal squamous(110;0.162)		Epithelial(14;5.75e-22)|OV - Ovarian serous cystadenocarcinoma(14;3.17e-20)|all cancers(14;7.07e-19)|LUSC - Lung squamous cell carcinoma(66;0.0221)			ACACACCCTCCGGAAACGGGG	0.532000													73	260					1.61169e-53	3.12824e-53	0.870114	1	0
PANK4	55229	broad.mit.edu	37	1	2444349	2444349	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:2444349A>C	ENST00000378466.3	-	13	1717	c.1705T>G	c.(1705-1707)Tgg>Ggg	p.W569G	PANK4_ENST00000435556.3_Missense_Mutation_p.W530G	NM_018216.1	NP_060686.1	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	569					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			breast(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	23	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		TTGGCCCCCCAGTCGAAGACA	0.697000													42	82					0	0	0.870114	0	0
RYR2	6262	broad.mit.edu	37	1	237791261	237791261	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:237791261G>T	ENST00000366574.2	+	41	6638	c.6321G>T	c.(6319-6321)acG>acT	p.T2107T	RYR2_ENST00000542537.1_Silent_p.T2091T|RYR2_ENST00000360064.6_Silent_p.T2105T	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2107	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGACCTACACGATAAATGGTG	0.547000													15	45					3.51602e-12	5.2134e-12	0.575678	1	0
LPHN1	22859	broad.mit.edu	37	19	14288458	14288458	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:14288458T>A	ENST00000340736.6	-	3	466	c.169A>T	c.(169-171)Atg>Ttg	p.M57L	LPHN1_ENST00000361434.3_Missense_Mutation_p.M57L	NM_001008701.2	NP_001008701.1	O94910	LPHN1_HUMAN	latrophilin 1	57	SUEL-type lectin.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TTCTCCACCATGATGACGTCG	0.642000													23	130					0	0	0.729181	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89476605	89476605	+	RNA	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:89476605G>A	ENST00000484817.1	-	0	39																											AGCTGAGCAAGGAGCCTCATT	0.552000													7	18					0	0	0.411799	0	0
UGT3A1	133688	broad.mit.edu	37	5	35965662	35965662	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:35965662G>T	ENST00000274278.3	-	4	1026	c.669C>A	c.(667-669)aaC>aaA	p.N223K	UGT3A1_ENST00000503189.1_Missense_Mutation_p.N223K|UGT3A1_ENST00000507113.1_Missense_Mutation_p.N189K|UGT3A1_ENST00000513233.1_Intron|UGT3A1_ENST00000333811.4_Missense_Mutation_p.N169K	NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	223						integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CCTTGATGGTGTTGTCAAATG	0.438000													10	56					2.27111e-07	2.90515e-07	0.411799	1	0
GPR112	139378	broad.mit.edu	37	X	135429898	135429898	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:135429898T>C	ENST00000394143.1	+	6	4324	c.4033T>C	c.(4033-4035)Tca>Cca	p.S1345P	GPR112_ENST00000394141.1_Missense_Mutation_p.S1140P|GPR112_ENST00000412101.1_Missense_Mutation_p.S1140P|GPR112_ENST00000370652.1_Missense_Mutation_p.S1345P|GPR112_ENST00000287534.4_Missense_Mutation_p.S1282P	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1345					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					AACCTTGACCTCAAGTAACAC	0.463000													9	78					0	0	0.411799	0	0
ZFP28	140612	broad.mit.edu	37	19	57051028	57051028	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:57051028G>C	ENST00000301318.3	+	2	314	c.243G>C	c.(241-243)gaG>gaC	p.E81D	ZFP28_ENST00000594386.1_3'UTR|ZFP28_ENST00000591844.1_Missense_Mutation_p.E81D	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	81					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		TTCCCCAGGAGAGAAACAAGA	0.507000													7	26					0	0	0.307466	0	0
PADI6	353238	broad.mit.edu	37	1	17725322	17725322	+	RNA	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:17725322G>A	ENST00000434762.2	+	0	1881							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GGTCCTTTGCGAGGCCATACT	0.612000													10	115					0	0	0.435327	0	0
BOD1L2	284257	broad.mit.edu	37	18	54814994	54814994	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:54814994G>T	ENST00000585477.1	+	1	702	c.451G>T	c.(451-453)Gct>Tct	p.A151S		NM_001257964.1	NP_001244893.1			biorientation of chromosomes in cell division 1-like 2																		GAAAGAAGCAGCTGTGCCAGC	0.488000													6	18					3.59834e-05	4.19931e-05	0.217242	1	0
OR2G2	81470	broad.mit.edu	37	1	247752214	247752214	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:247752214C>G	ENST00000320065.1	+	1	553	c.553C>G	c.(553-555)Cct>Gct	p.P185A	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	185					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CTGCGAGGTCCCTGTGCTCAT	0.532000													14	156					0	0	0.500413	0	0
ABI3BP	25890	broad.mit.edu	37	3	100621500	100621500	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:100621500C>A	ENST00000471714.1	-	3	420	c.311G>T	c.(310-312)cGa>cTa	p.R104L	ABI3BP_ENST00000495063.1_Missense_Mutation_p.R104L|ABI3BP_ENST00000532144.1_5'UTR|ABI3BP_ENST00000284322.5_Missense_Mutation_p.R104L			Q7Z7G0	TARSH_HUMAN	ABI family, member 3 (NESH) binding protein	104						extracellular space				central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	50						TGGAGCAGGTCGCACAACTAT	0.408000													6	40					0.00448238	0.00482784	0.307466	1	0
SERPINB12	89777	broad.mit.edu	37	18	61223490	61223490	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:61223490T>C	ENST00000382768.1	+	1	98	c.98T>C	c.(97-99)cTg>cCg	p.L33P	SERPINB12_ENST00000269491.1_Missense_Mutation_p.L33P			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	33					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TTCTCTCCCCTGAGCCTCTCA	0.443000													3	135					0	0	0.729181	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518823	113518823	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:113518823G>C	ENST00000284601.3	-	4	2392	c.2324C>G	c.(2323-2325)cCa>cGa	p.P775R		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	775					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						CCCTTCATGTGGATCAAACGC	0.403000													17	63					0	0	0.575678	0	0
MARK3	4140	broad.mit.edu	37	14	103969433	103969433	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:103969433G>T	ENST00000429436.2	+	18	2641	c.2131G>T	c.(2131-2133)Gtg>Ttg	p.V711L	MARK3_ENST00000335102.5_Missense_Mutation_p.V734L|MARK3_ENST00000216288.7_Missense_Mutation_p.V671L|MARK3_ENST00000303622.9_Missense_Mutation_p.V687L|MARK3_ENST00000416682.2_Missense_Mutation_p.V710L|MARK3_ENST00000553942.1_Missense_Mutation_p.V702L|MARK3_ENST00000440884.3_Missense_Mutation_p.V617L	NM_001128918.1|NM_001128919.1	NP_001122390.1|NP_001122391.1	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	711	KA1.						ATP binding|protein binding|protein serine/threonine kinase activity	p.V671M(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30		Melanoma(154;0.155)	Epithelial(46;0.241)			GGAGAACCTCGTGCAGTGGGA	0.537000													23	65					9.57634e-11	1.35523e-10	0.654019	1	0
DUPD1	338599	broad.mit.edu	37	10	76818170	76818170	+	Missense_Mutation	SNP	T	T	A	rs146256162		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:76818170T>A	ENST00000338487.5	-	1	102	c.103A>T	c.(103-105)Acc>Tcc	p.T35S		NM_001003892.1	NP_001003892.1	Q68J44	DUPD1_HUMAN	dual specificity phosphatase and pro isomerase domain containing 1	35						cytoplasm	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(2)|lung(5)|ovary(2)|urinary_tract(1)	11	all_cancers(46;0.0207)|all_epithelial(25;0.00126)|Prostate(51;0.0112)|Ovarian(15;0.0348)					GCTCCAGGGGTGCAGTAGTCC	0.572000													10	30					0	0	0.361761	0	0
VN1R2	317701	broad.mit.edu	37	19	53762244	53762244	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:53762244C>A	ENST00000341702.3	+	1	700	c.616C>A	c.(616-618)Ccg>Acg	p.P206T		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	206					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity	p.P206T(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		AGTAAAAGCCCCGACATACAT	0.483000													12	18					0.000151284	0.000172588	0.435327	1	0
AFAP1L2	84632	broad.mit.edu	37	10	116060248	116060248	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:116060248G>T	ENST00000369271.3	-	14	2044	c.1744C>A	c.(1744-1746)Cca>Aca	p.P582T	AFAP1L2_ENST00000304129.4_Missense_Mutation_p.P582T|AFAP1L2_ENST00000545353.1_Missense_Mutation_p.P635T|AFAP1L2_ENST00000491814.1_5'UTR	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	582					inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GGCTCATCTGGGGTGGGACCT	0.647000													26	43					1.2476e-16	2.0512e-16	0.706142	1	0
IGLV9-49	28773	broad.mit.edu	37	22	22697764	22697764	+	RNA	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr22:22697764C>T	ENST00000427632.2	+	0	89																											TCCAGGGTCCCTCTCCCAGCC	0.597000											OREG0026357	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	31					0	0	0.278610	0	0
COL9A3	1299	broad.mit.edu	37	20	61453473	61453473	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:61453473G>T	ENST00000343916.3	+	9	437	c.434G>T	c.(433-435)gGa>gTa	p.G145V		NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	145	Triple-helical region 3 (COL3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					GGACCTTCTGGACTCCCCGGC	0.652000													14	44					3.51602e-12	5.2134e-12	0.575678	1	0
CR1	1378	broad.mit.edu	37	1	207803918	207803918	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:207803918G>A	ENST00000367049.4	+	46	7409	c.7409G>A	c.(7408-7410)gGc>gAc	p.G2470D	CR1_ENST00000400960.2_Missense_Mutation_p.G2020D|CR1_ENST00000367052.1_Missense_Mutation_p.G2020D|CR1_ENST00000367053.1_Missense_Mutation_p.G2020D|CR1_ENST00000367051.1_Missense_Mutation_p.G2020D	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	2020					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						TCTCAAGGAGGCAGCAGCGTT	0.338000													7	17					0	0	0.307466	0	0
STRA6	64220	broad.mit.edu	37	15	74473702	74473702	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:74473702T>A	ENST00000323940.5	-	17	1863	c.1618A>T	c.(1618-1620)Aac>Tac	p.N540Y	STRA6_ENST00000535552.1_Missense_Mutation_p.N577Y|STRA6_ENST00000563965.1_Missense_Mutation_p.N579Y|STRA6_ENST00000449139.2_Missense_Mutation_p.N540Y|STRA6_ENST00000574278.1_Missense_Mutation_p.N555Y|STRA6_ENST00000423167.2_Missense_Mutation_p.N531Y|STRA6_ENST00000416286.3_Missense_Mutation_p.N532Y|STRA6_ENST00000574439.1_5'UTR|STRA6_ENST00000395105.4_Missense_Mutation_p.N540Y	NM_001142617.1|NM_001142618.1|NM_001142619.1	NP_001136089.1|NP_001136090.1|NP_001136091.1	Q9BX79	STRA6_HUMAN	stimulated by retinoic acid 6	540					adrenal gland development|alveolar primary septum development|developmental growth|diaphragm development|digestive tract morphogenesis|ear development|embryonic camera-type eye formation|embryonic digestive tract development|eyelid development in camera-type eye|face morphogenesis|feeding behavior|female genitalia development|kidney development|lung vasculature development|neuromuscular process|nose morphogenesis|paramesonephric duct development|positive regulation of behavior|pulmonary artery morphogenesis|pulmonary valve morphogenesis|smooth muscle tissue development|transport|uterus morphogenesis|ventricular septum development|vocal learning	integral to membrane|plasma membrane|protein complex	receptor activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(5)|skin(1)|stomach(2)	26						TGGATGGCGTTGTAGAGGGCA	0.627000													6	27					0	0	0.248553	0	0
TECTA	7007	broad.mit.edu	37	11	120996152	120996152	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:120996152G>T	ENST00000392793.1	+	8	1616	c.1345G>T	c.(1345-1347)Gtc>Ttc	p.V449F	TECTA_ENST00000264037.2_Missense_Mutation_p.V449F			O75443	TECTA_HUMAN	tectorin alpha	449	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix		p.V449I(1)	TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CTCCATTTCCGTCCCAGGCTC	0.512000													115	155					1.05585e-87	2.11549e-87	0.870114	1	0
KDR	3791	broad.mit.edu	37	4	55961097	55961097	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:55961097C>A	ENST00000263923.4	-	21	3138	c.2843G>T	c.(2842-2844)gGg>gTg	p.G948V		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	948	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.G948E(1)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GTAGTCTTTCCCTTGACGGAA	0.443000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			9	37					4.68919e-08	6.15319e-08	0.361761	1	0
GPR158	57512	broad.mit.edu	37	10	25464725	25464725	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:25464725C>A	ENST00000376351.3	+	1	735	c.376C>A	c.(376-378)Ctg>Atg	p.L126M	GPR158-AS1_ENST00000449643.1_RNA	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	126						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						GCACCGGGCGCTGGACACACT	0.652000													31	100					4.32679e-17	7.28517e-17	0.827153	1	0
PTPN2	5771	broad.mit.edu	37	18	12817351	12817351	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:12817351C>A	ENST00000309660.5	-	6	602	c.509G>T	c.(508-510)aGa>aTa	p.R170I	PTPN2_ENST00000353319.4_Missense_Mutation_p.R170I|PTPN2_ENST00000327283.3_Missense_Mutation_p.R170I|PTPN2_ENST00000591115.1_Missense_Mutation_p.R193I|PTPN2_ENST00000591497.1_Missense_Mutation_p.R141I	NM_002828.3	NP_002819.2	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type 2	170	Tyrosine-protein phosphatase.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)|skin(3)	13		Lung NSC(161;8.94e-06)				AGATATTGTTCTGGTTTCACC	0.328000													11	35					1.15088e-07	1.48235e-07	0.500413	1	0
FASLG	356	broad.mit.edu	37	1	172633496	172633496	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:172633496A>G	ENST00000340030.3	+	2	559	c.371A>G	c.(370-372)aAa>aGa	p.K124R	FASLG_ENST00000367721.2_Silent_p.E139E			P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	0					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						CACCCCCTGAAAAAAAGGAGC	0.413000													18	31					0	0	0.667858	0	0
SORCS3	22986	broad.mit.edu	37	10	106983008	106983008	+	Splice_Site	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:106983008G>T	ENST00000369701.3	+	20	3095		c.e20+1		SORCS3_ENST00000369699.4_Splice_Site	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3							integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		TAGCACAAAGGTTTGGCCCTT	0.453000													47	153					6.83704e-37	1.30887e-36	0.870114	1	0
ZNF417	147687	broad.mit.edu	37	19	58420128	58420128	+	Silent	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:58420128C>G	ENST00000312026.5	-	3	1682	c.1518G>C	c.(1516-1518)gcG>gcC	p.A506A	ZNF417_ENST00000595559.1_Silent_p.A505A|CTD-2583A14.9_ENST00000602124.1_Intron|ZNF417_ENST00000536263.1_Silent_p.A307A	NM_152475.2	NP_689688.2	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|stomach(3)|upper_aerodigestive_tract(1)	18		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		GAACATGAAGCGCAGAGCTGG	0.398000													26	56					0	0	0.693898	0	0
CSMD1	64478	broad.mit.edu	37	8	2796233	2796233	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:2796233A>T	ENST00000520002.1	-	71	11127	c.10572T>A	c.(10570-10572)gcT>gcA	p.A3524A	CSMD1_ENST00000542608.1_Silent_p.A3346A|CSMD1_ENST00000602723.1_Silent_p.A3347A|CSMD1_ENST00000400186.3_Silent_p.A3347A|CSMD1_ENST00000602557.1_Silent_p.A3524A|CSMD1_ENST00000537824.1_Silent_p.A3523A			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3524						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TTTCATGCCCAGCATAGCCAT	0.408000													5	8					0	0	0.248553	0	0
DOPEY1	23033	broad.mit.edu	37	6	83823062	83823062	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:83823062A>T	ENST00000349129.2	+	7	962	c.702A>T	c.(700-702)tcA>tcT	p.S234S	DOPEY1_ENST00000237163.5_Silent_p.S234S|DOPEY1_ENST00000536812.1_3'UTR|DOPEY1_ENST00000369739.3_Silent_p.S234S	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	234					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TAAGTACTTCAGTGCAGGACT	0.378000													25	37					0	0	0.750413	0	0
TRAJ31	28724	broad.mit.edu	37	14	22979963	22979963	+	RNA	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:22979963C>A	ENST00000390506.1	+	0	13																											AATAACAATGCCAGACTCATG	0.448000													5	18					2.0095e-06	2.44198e-06	0.248553	1	0
CHSY3	337876	broad.mit.edu	37	5	129520708	129520708	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:129520708G>A	ENST00000305031.4	+	3	2231	c.1873G>A	c.(1873-1875)Gtt>Att	p.V625I		NM_175856.4	NP_787052.3	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	625						Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|urinary_tract(1)	28		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		ACACATTCTCGTTCCTCTCAT	0.353000													5	37					0	0	0.217242	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599512	136599512	+	Silent	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr6:136599512A>T	ENST00000531224.1	-	4	759	c.507T>A	c.(505-507)gcT>gcA	p.A169A	BCLAF1_ENST00000353331.4_Silent_p.A167A|BCLAF1_ENST00000530767.1_Silent_p.A169A|BCLAF1_ENST00000392348.2_Silent_p.A167A|BCLAF1_ENST00000527759.1_Silent_p.A167A|BCLAF1_ENST00000527536.1_Silent_p.A169A	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	169					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GTTCCCCTTCAGCTTTTTTGG	0.418000													15	119					0	0	0.608945	0	0
DYM	54808	broad.mit.edu	37	18	46808504	46808504	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:46808504T>A	ENST00000269445.6	-	10	1445	c.988A>T	c.(988-990)Atc>Ttc	p.I330F	DYM_ENST00000442713.2_Missense_Mutation_p.I140F	NM_017653.3	NP_060123.3	Q7RTS9	DYM_HUMAN	dymeclin	330						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						TTAAAGTTGATCTGGAAGGCA	0.363000													19	48					0	0	0.681144	0	0
SELP	6403	broad.mit.edu	37	1	169572267	169572267	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:169572267C>A	ENST00000263686.6	-	10	1739	c.1702G>T	c.(1702-1704)Gaa>Taa	p.E568*	SELP_ENST00000367792.2_Intron|SELP_ENST00000367791.2_Nonsense_Mutation_p.E444*|SELP_ENST00000367786.2_Nonsense_Mutation_p.E506*|SELP_ENST00000367788.2_Nonsense_Mutation_p.E506*|SELP_ENST00000367794.2_Nonsense_Mutation_p.E506*|SELP_ENST00000367793.2_Nonsense_Mutation_p.E506*|SELP_ENST00000458599.2_Intron	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	568	Sushi 6.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	AGCCTACCTTCACACATTGGT	0.443000													31	51					8.73648e-17	1.44488e-16	0.796494	1	0
ANK3	288	broad.mit.edu	37	10	61956332	61956332	+	Missense_Mutation	SNP	C	C	T	rs140324936		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr10:61956332C>T	ENST00000280772.1	-	15	1932	c.1741G>A	c.(1741-1743)Gcc>Acc	p.A581T	ANK3_ENST00000503366.1_Missense_Mutation_p.A564T|ANK3_ENST00000373827.2_Missense_Mutation_p.A575T	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	581					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGGAGATTGGCGACTTCAAGC	0.408000													9	30					0	0	0.457914	0	0
CACNA1G	8913	broad.mit.edu	37	17	48680441	48680441	+	Silent	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:48680441C>T	ENST00000352832.5	+	20	4353	c.3981C>T	c.(3979-3981)gaC>gaT	p.D1327D	CACNA1G_ENST00000507336.1_Silent_p.D1350D|CACNA1G_ENST00000513964.1_Silent_p.D1350D|CACNA1G_ENST00000513689.2_Silent_p.D1350D|CACNA1G_ENST00000514079.1_Silent_p.D1350D|CACNA1G_ENST00000416767.4_Silent_p.D1350D|CACNA1G_ENST00000360761.4_Silent_p.D1327D|CACNA1G_ENST00000510366.1_Silent_p.D1350D|CACNA1G_ENST00000503485.1_Silent_p.D1350D|CACNA1G_ENST00000512389.1_Silent_p.D1350D|CACNA1G_ENST00000510115.1_Silent_p.D1327D|CACNA1G_ENST00000507896.1_Silent_p.D1350D|CACNA1G_ENST00000502264.1_Silent_p.D1327D|CACNA1G_ENST00000358244.5_Silent_p.D1327D|CACNA1G_ENST00000507609.1_Silent_p.D1350D|CACNA1G_ENST00000359106.5_Silent_p.D1350D|CACNA1G_ENST00000442258.2_Silent_p.D1327D|CACNA1G_ENST00000505165.1_Silent_p.D1350D|CACNA1G_ENST00000429973.2_Silent_p.D1350D|CACNA1G_ENST00000507510.2_Silent_p.D1350D|CACNA1G_ENST00000515411.1_Silent_p.D1350D|CACNA1G_ENST00000515165.1_Silent_p.D1350D|CACNA1G_ENST00000515765.1_Silent_p.D1350D|CACNA1G_ENST00000514717.1_Silent_p.D1327D|CACNA1G_ENST00000354983.4_Silent_p.D1327D|CACNA1G_ENST00000514181.1_Silent_p.D1350D	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1350					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	ACGTGCTGGACGGGCTGTTGG	0.657000													7	140					0	0	0.248553	0	0
OCA2	4948	broad.mit.edu	37	15	28270017	28270017	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr15:28270017G>T	ENST00000354638.3	-	5	702	c.547C>A	c.(547-549)Ctg>Atg	p.L183M	OCA2_ENST00000382996.2_Missense_Mutation_p.L183M|OCA2_ENST00000353809.5_Missense_Mutation_p.L183M	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	183					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AAGGCAAACAGGCCCATGACT	0.552000									Oculocutaneous Albinism				6	48					5.18039e-06	6.20094e-06	0.278610	1	0
MAP1S	55201	broad.mit.edu	37	19	17837202	17837202	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:17837202G>T	ENST00000324096.4	+	5	1160	c.1009G>T	c.(1009-1011)Gtg>Ttg	p.V337L	MAP1S_ENST00000544059.2_Missense_Mutation_p.V311L|MAP1S_ENST00000597681.1_Intron	NM_018174.4	NP_060644.4	Q66K74	MAP1S_HUMAN	microtubule-associated protein 1S	337	Necessary for the microtubule-organizing center localization.				apoptosis|brain development|microtubule bundle formation|mitochondrion transport along microtubule|neuron projection morphogenesis	cytosol|dendrite|microtubule|neuronal cell body|nucleus|perinuclear region of cytoplasm|spindle|synapse	actin filament binding|beta-tubulin binding|DNA binding|microtubule binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	25						CCTGGGGGTCGTGTTCTTCAA	0.721000													3	5					0.000602214	0.000665292	0.184627	1	0
ABCB5	340273	broad.mit.edu	37	7	20782591	20782591	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:20782591G>T	ENST00000404938.2	+	25	3768	c.3116G>T	c.(3115-3117)aGt>aTt	p.S1039I	ABCB5_ENST00000258738.6_Missense_Mutation_p.S594I	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	594					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TTATCCCTCAGTATTGAGCGA	0.478000													13	45					1.52009e-12	2.29038e-12	0.479597	1	0
FREM2	341640	broad.mit.edu	37	13	39357301	39357301	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr13:39357301G>T	ENST00000280481.7	+	5	5952	c.5736G>T	c.(5734-5736)caG>caT	p.Q1912H		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1912	Calx-beta 2.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		ATGTGAGCCAGGAGTTGATGG	0.433000													31	73					5.04308e-16	8.14763e-16	0.819951	1	0
R3HDM1	23518	broad.mit.edu	37	2	136473252	136473252	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:136473252G>T	ENST00000264160.4	+	23	3134	c.2764G>T	c.(2764-2766)Gtc>Ttc	p.V922F	R3HDM1_ENST00000409606.1_Missense_Mutation_p.V923F|R3HDM1_ENST00000329971.3_Missense_Mutation_p.V793F|R3HDM1_ENST00000410054.1_Missense_Mutation_p.V867F|R3HDM1_ENST00000409478.1_Missense_Mutation_p.V794F	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	922							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		TAGACCTTTTGTCCCCGGGCA	0.473000													28	117					1.36615e-20	2.37905e-20	0.769981	1	0
CSRP3	8048	broad.mit.edu	37	11	19207884	19207884	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:19207884G>T	ENST00000533783.1	-	5	533	c.293C>A	c.(292-294)cCg>cAg	p.P98Q	CSRP3_ENST00000265968.3_Missense_Mutation_p.P98Q	NM_003476.4	NP_003467.1	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3 (cardiac LIM protein)	98					cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding			kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10						TGAGCGTGCCGGCTTTGGGGA	0.502000													18	39					9.95505e-16	1.59452e-15	0.624587	1	0
GPR174	84636	broad.mit.edu	37	X	78427211	78427211	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:78427211C>A	ENST00000276077.1	+	1	743	c.707C>A	c.(706-708)gCa>gAa	p.A236E		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	236						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						CTAACCTGTGCAGGGGTATTC	0.408000										HNSCC(63;0.18)			6	50					2.0095e-06	2.44198e-06	0.248553	1	0
PDE4A	5141	broad.mit.edu	37	19	10578180	10578180	+	Silent	SNP	C	C	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:10578180C>G	ENST00000380702.2	+	16	2478	c.2478C>G	c.(2476-2478)gcC>gcG	p.A826A	PDE4A_ENST00000592685.1_Silent_p.A826A|PDE4A_ENST00000293683.5_Silent_p.A822A|PDE4A_ENST00000440014.2_Silent_p.A787A|PDE4A_ENST00000344979.3_Silent_p.A609A|PDE4A_ENST00000352831.6_Silent_p.A848A			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	848					signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	AGGTGGAGGCCCAACGAGAGC	0.677000													26	46					0	0	0.717897	0	0
SERPINB12	89777	broad.mit.edu	37	18	61223491	61223491	+	Silent	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:61223491G>C	ENST00000382768.1	+	1	99	c.99G>C	c.(97-99)ctG>ctC	p.L33L	SERPINB12_ENST00000269491.1_Silent_p.L33L			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	33					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TCTCTCCCCTGAGCCTCTCAG	0.448000													3	137					0	0	0.729181	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110451322	110451322	+	Splice_Site	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:110451322G>T	ENST00000378402.5	+	32	4060		c.e32+1			NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1						immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATCAACAAGGTATGATAATG	0.388000										HNSCC(38;0.096)			26	57					5.91797e-21	1.0403e-20	0.760397	1	0
CPZ	8532	broad.mit.edu	37	4	8621068	8621068	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:8621068C>A	ENST00000429646.2	+	9	3300	c.507C>A	c.(505-507)gtC>gtA	p.V169V	CPZ_ENST00000382480.2_Silent_p.V424V|CPZ_ENST00000315782.6_Silent_p.V550V|CPZ_ENST00000360986.4_Silent_p.V561V			Q66K79	CBPZ_HUMAN	carboxypeptidase Z	561					proteolysis|Wnt receptor signaling pathway	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(23)|ovary(3)|pancreas(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						ACGCCAAAGTCATCAAGAAAG	0.532000													4	21					3.59834e-05	4.19931e-05	0.217242	1	0
OR2G6	391211	broad.mit.edu	37	1	248685327	248685327	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:248685327G>T	ENST00000343414.4	+	1	412	c.380G>T	c.(379-381)tGc>tTc	p.C127F		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCTGCTGTCTGCCGGCCACTG	0.592000													15	42					1.49906e-05	1.76416e-05	0.457914	1	0
SH3BP2	6452	broad.mit.edu	37	4	2831520	2831520	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:2831520G>T	ENST00000442312.2	+	8	1150	c.971G>T	c.(970-972)tGc>tTc	p.C324F	SH3BP2_ENST00000503393.2_Missense_Mutation_p.C353F|SH3BP2_ENST00000435136.2_Missense_Mutation_p.C296F|SH3BP2_ENST00000356331.5_Missense_Mutation_p.C296F|SH3BP2_ENST00000452765.2_Missense_Mutation_p.C296F|SH3BP2_ENST00000511747.1_Missense_Mutation_p.C296F	NM_001145855.1	NP_001139327.1	P78314	3BP2_HUMAN	SH3-domain binding protein 2	296					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		AAACCCCCTTGCTTCCGGGAG	0.697000									Cherubism				19	47					6.21321e-17	1.03677e-16	0.639603	1	0
DIDO1	11083	broad.mit.edu	37	20	61537357	61537357	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr20:61537357T>A	ENST00000266070.4	-	6	1795	c.1470A>T	c.(1468-1470)gaA>gaT	p.E490D	DIDO1_ENST00000370366.1_Missense_Mutation_p.E490D|DIDO1_ENST00000395335.2_Missense_Mutation_p.E490D|DIDO1_ENST00000370371.4_Missense_Mutation_p.E490D|DIDO1_ENST00000266071.5_Missense_Mutation_p.E490D|DIDO1_ENST00000370368.1_Missense_Mutation_p.E490D|DIDO1_ENST00000354665.4_Missense_Mutation_p.E490D|DIDO1_ENST00000395343.1_Missense_Mutation_p.E490D|DIDO1_ENST00000395340.1_Missense_Mutation_p.E490D	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	490					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TCCCGAGTGCTTCACTCCGCG	0.532000													24	86					0	0	0.706142	0	0
MYH8	4626	broad.mit.edu	37	17	10318895	10318895	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:10318895C>A	ENST00000403437.2	-	7	636	c.542G>T	c.(541-543)gGa>gTa	p.G181V	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	181	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						ACCAGATTCTCCGCTGTCAAA	0.413000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				24	87					1.61788e-16	2.64443e-16	0.760397	1	0
CILP2	148113	broad.mit.edu	37	19	19651072	19651072	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:19651072G>C	ENST00000586018.1	+	3	343	c.241G>C	c.(241-243)Gag>Cag	p.E81Q	CILP2_ENST00000291495.4_Missense_Mutation_p.E75Q			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	75						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						CGGCGACTTCGAGAGCCTGGC	0.736000													2	7					0	0	0.115264	0	0
TBR1	10716	broad.mit.edu	37	2	162273093	162273093	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:162273093G>T	ENST00000389554.3	+	1	489	c.172G>T	c.(172-174)Ggg>Tgg	p.G58W		NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	58						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						AATTACCAGGGGGATGACGAA	0.498000													12	54					0.11911	0.122619	0.457914	1	0
NCAM2	4685	broad.mit.edu	37	21	22910226	22910226	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr21:22910226T>C	ENST00000400546.1	+	18	2711	c.2462T>C	c.(2461-2463)aTt>aCt	p.I821T	NCAM2_ENST00000284894.7_Missense_Mutation_p.I679T	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	821					neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		ACTATAGAAATTAAAGTTTCT	0.323000													6	7					0	0	0.248553	0	0
GRID2	2895	broad.mit.edu	37	4	94690475	94690475	+	Silent	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:94690475C>A	ENST00000282020.4	+	15	2733	c.2475C>A	c.(2473-2475)gcC>gcA	p.A825A	GRID2_ENST00000510992.1_Silent_p.A730A	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	825					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	AAGGAGGCGCCCTGGACATAA	0.517000													7	44					8.12818e-05	9.38772e-05	0.248553	1	0
OR4A5	81318	broad.mit.edu	37	11	51412120	51412120	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:51412120G>T	ENST00000319760.6	-	1	328	c.276C>A	c.(274-276)ttC>ttA	p.F92L		NM_001005272.3	NP_001005272.3	Q8NH83	OR4A5_HUMAN	olfactory receptor, family 4, subfamily A, member 5	92					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(28)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	49		all_lung(304;0.236)				TGCAACCTTGGAAGGAAATAG	0.443000													11	54					6.40141e-05	7.42404e-05	0.387290	1	0
CPQ	10404	broad.mit.edu	37	8	97892089	97892089	+	Silent	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr8:97892089G>T	ENST00000220763.5	+	4	915	c.705G>T	c.(703-705)acG>acT	p.T235T		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	235					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										CCTGTATTACGGTGGAAGATG	0.463000													71	129					9.11151e-29	1.69214e-28	0.870114	1	0
MURC	347273	broad.mit.edu	37	9	103340821	103340821	+	Silent	SNP	G	G	C			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:103340821G>C	ENST00000307584.5	+	1	461	c.396G>C	c.(394-396)gtG>gtC	p.V132V		NM_001018116.1	NP_001018126.1	Q5BKX8	MURC_HUMAN	muscle-related coiled-coil protein	132					cell differentiation|muscle organ development|transcription, DNA-dependent					endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)	16		Acute lymphoblastic leukemia(62;0.0461)				AATTCCGCGTGGTAATATTCC	0.378000													7	46					0	0	0.335167	0	0
CLMP	79827	broad.mit.edu	37	11	122968652	122968652	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:122968652A>T	ENST00000448775.2	-	2	377	c.37T>A	c.(37-39)Tat>Aat	p.Y13N		NM_024769.2	NP_079045.1	Q9H6B4	CLMP_HUMAN	CXADR-like membrane protein	13						integral to membrane|tight junction				endometrium(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	14						GTTCCAACATAGTAGGAAACT	0.458000													21	24					0	0	0.681144	0	0
NXF5	55998	broad.mit.edu	37	X	101096692	101096692	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:101096692G>T	ENST00000537026.1	-	5	553	c.194C>A	c.(193-195)gCa>gAa	p.A65E	NXF5_ENST00000473265.2_Missense_Mutation_p.A65E|NXF5_ENST00000361708.2_Missense_Mutation_p.A65E	NM_032946.2	NP_116564.2	Q9H1B4	NXF5_HUMAN	nuclear RNA export factor 5	65	RRM.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nucleus	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|skin(1)	30						ATCCTTCAATGCAGAGGCAGC	0.493000													48	106					9.5628e-27	1.76423e-26	0.870114	1	0
FAM154A	158297	broad.mit.edu	37	9	18928468	18928468	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr9:18928468C>A	ENST00000380534.4	-	4	1286	c.1007G>T	c.(1006-1008)gGc>gTc	p.G336V	FAM154A_ENST00000380530.1_3'UTR|FAM154A_ENST00000542071.1_Missense_Mutation_p.G144V	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	336										breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		GGTGGAAGAGCCTTCAAAGCG	0.587000													12	27					0.000151284	0.000172588	0.435327	1	0
RNF121	55298	broad.mit.edu	37	11	71668281	71668281	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:71668281G>A	ENST00000361756.3	+	2	433	c.72G>A	c.(70-72)atG>atA	p.M24I	RNF121_ENST00000530137.1_Intron|RNF121_ENST00000393713.3_Intron|RNF121_ENST00000490867.1_3'UTR|RNF121_ENST00000545854.1_Intron|RNF121_ENST00000533380.1_Intron	NM_018320.4	NP_060790.2	Q9H920	RN121_HUMAN	ring finger protein 121	24						integral to membrane	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|urinary_tract(1)	13						AGGTTGATATGTCAGATCTCT	0.438000													38	65					0	0	0.870114	0	0
PABPC5	140886	broad.mit.edu	37	X	90691703	90691703	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:90691703G>T	ENST00000312600.3	+	2	1341	c.1127G>T	c.(1126-1128)gGc>gTc	p.G376V	PABPC5_ENST00000373105.1_Missense_Mutation_p.G212V	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	376	RRM 4.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						GTCACCCTGGGCCAGGCCAGG	0.507000													5	8					0.000602214	0.000665292	0.184627	1	0
TIGIT	201633	broad.mit.edu	37	3	114014665	114014665	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:114014665C>T	ENST00000481065.1	+	3	3151	c.536C>T	c.(535-537)aCc>aTc	p.T179I	TIGIT_ENST00000383671.3_Missense_Mutation_p.T112I|TIGIT_ENST00000486257.1_Missense_Mutation_p.T112I			Q495A1	TIGIT_HUMAN	T cell immunoreceptor with Ig and ITIM domains	112					negative regulation of interleukin-12 production|negative regulation of T cell activation|positive regulation of interleukin-10 production	cell surface|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(7)|prostate(1)	17						ATCTATCACACCTACCCTGAT	0.562000													15	31					0	0	0.520397	0	0
ZNF57	126295	broad.mit.edu	37	19	2917873	2917873	+	Silent	SNP	G	G	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:2917873G>A	ENST00000306908.5	+	4	1402	c.1254G>A	c.(1252-1254)aaG>aaA	p.K418K	ZNF57_ENST00000523428.1_Silent_p.K386K|AC006277.2_ENST00000520090.2_RNA	NM_173480.2	NP_775751.1	Q68EA5	ZNF57_HUMAN	zinc finger protein 57	418					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGGAGAGAAGCCTTATGAGT	0.438000													3	49					0	0	0.184627	0	0
MIA2	117153	broad.mit.edu	37	14	39722068	39722068	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr14:39722068G>T	ENST00000280082.3	+	5	1883	c.1684G>T	c.(1684-1686)Gct>Tct	p.A562S	RP11-407N17.3_ENST00000553728.1_Intron	NM_054024.3	NP_473365.3	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	0						extracellular region				NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	31	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		CGAAGGGCCTGCTCTGGTGGA	0.378000													11	42					9.31168e-06	1.1075e-05	0.435327	1	0
TTC17	55761	broad.mit.edu	37	11	43511837	43511837	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:43511837G>T	ENST00000039989.4	+	22	3093	c.3079G>T	c.(3079-3081)Gtg>Ttg	p.V1027L		NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	1027							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						CTACTGGAGGGTGAAAGGCCA	0.542000													30	55					4.3181e-19	7.3817e-19	0.769981	1	0
ADGRE4P	326342	broad.mit.edu	37	19	6988821	6988821	+	RNA	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:6988821C>A	ENST00000600751.1	-	0	109					NR_024075.1																						GGCTTCTGATCCTGGCAGAGC	0.532000													27	52					3.90053e-15	6.17676e-15	0.760397	1	0
CPXCR1	53336	broad.mit.edu	37	X	88009037	88009037	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:88009037C>T	ENST00000276127.4	+	3	881	c.622C>T	c.(622-624)Ctc>Ttc	p.L208F	CPXCR1_ENST00000373111.1_Missense_Mutation_p.L208F	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	208						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						CTACCGTCCCCTCACTGAGAG	0.428000													6	19					0	0	0.217242	0	0
ULK2	9706	broad.mit.edu	37	17	19705218	19705218	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:19705218C>A	ENST00000395544.4	-	16	1812	c.1313G>T	c.(1312-1314)aGg>aTg	p.R438M	ULK2_ENST00000580130.1_5'UTR|ULK2_ENST00000361658.2_Missense_Mutation_p.R438M	NM_014683.3	NP_055498.3	Q8IYT8	ULK2_HUMAN	unc-51 like autophagy activating kinase 2	438					signal transduction		ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|skin(4)|stomach(1)	6	all_cancers(12;4.97e-05)|all_epithelial(12;0.00362)|Breast(13;0.186)					GGTGTTGGACCTTCGTACCAC	0.473000													45	136					2.81731e-22	5.01552e-22	0.870114	1	0
ZNF608	57507	broad.mit.edu	37	5	124036777	124036777	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:124036777C>A	ENST00000306315.5	-	2	1527	c.1092G>T	c.(1090-1092)gaG>gaT	p.E364D	ZNF608_ENST00000504926.1_5'UTR	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	364						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCCAAGACACTCTGGCTCTG	0.443000													17	56					1.87028e-06	2.29274e-06	0.608945	1	0
DYRK3	8444	broad.mit.edu	37	1	206809097	206809097	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr1:206809097delG	ENST00000367109.2	+	1	217	c.49delG	c.(49-51)ggfs	p.G17fs	DYRK3_ENST00000367108.3_5'UTR|DYRK3_ENST00000489878.1_3'UTR	NM_003582.2	NP_003573.2	O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	17					erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			GGGGCCGCCTGGGGCCGGGCT	0.756													4	6	---	---	---	---					
SLC8A1	6546	broad.mit.edu	37	2	40366616	40366616	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:40366616delG	ENST00000406785.1	-	7	2551	c.2362delC	c.(2362-2364)acfs	p.H788fs	SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1_ENST00000408028.2_Frame_Shift_Del_p.H816fs|SLC8A1_ENST00000406391.2_Frame_Shift_Del_p.H788fs|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1_ENST00000405269.1_Frame_Shift_Del_p.H788fs|SLC8A1_ENST00000403092.1_Frame_Shift_Del_p.H824fs|SLC8A1_ENST00000402441.1_Frame_Shift_Del_p.H788fs|SLC8A1_ENST00000332839.4_Frame_Shift_Del_p.H824fs|SLC8A1_ENST00000542756.1_Frame_Shift_Del_p.H819fs|SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1_ENST00000542024.1_Frame_Shift_Del_p.H788fs|SLC8A1_ENST00000405901.3_Frame_Shift_Del_p.H819fs			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	824					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	CAGCCAAAGTGGGAAGCCAGG	0.483													16	36	---	---	---	---					
LRP1B	53353	broad.mit.edu	37	2	141108483	141108483	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr2:141108483delC	ENST00000389484.3	-	77	12746	c.11775delG	c.(11773-11775)ggfs	p.G3925fs		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3925					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATACATCCATCCCTGTTATTC	0.343										TSP Lung(27;0.18)			47	106	---	---	---	---					
OR5AC1	81431	broad.mit.edu	37	3	97783701	97783701	+	RNA	DEL	C	C	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:97783701delC	ENST00000429239.1	+	0	386									olfactory receptor, family 5, subfamily AC, member 1 (gene/pseudogene)																		CATATGCAATCCCTTGCTTTA	0.418													21	54	---	---	---	---					
PHC3	80012	broad.mit.edu	37	3	169889137	169889138	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr3:169889137_169889138insA	ENST00000497658.1	-	4	454_455	c.437_438insT	c.(436-438)tctfs	p.S146fs	PHC3_ENST00000495893.1_Intron|PHC3_ENST00000494943.1_Intron|PHC3_ENST00000474275.1_Intron|PHC3_ENST00000467570.1_Intron|PHC3_ENST00000481639.1_Frame_Shift_Ins_p.S142fs			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	782	Ser-rich.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			TTAAATCCAGGAAAAAAAAATT	0.337													2	4	---	---	---	---					
CXXC4	80319	broad.mit.edu	37	4	105412094	105412096	+	In_Frame_Del	DEL	GAG	GAG	-	rs146939312		TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr4:105412094_105412096delGAG	ENST00000394767.2	-	2	1314_1316	c.864_866delCTC	c.(862-867)tcg>tc	p.SS290del	CXXC4_ENST00000426831.1_In_Frame_Del_p.SS121del|AC093628.1_ENST00000606234.1_RNA|CXXC4_ENST00000466963.1_Intron	NM_025212.2	NP_079488.2	Q9H2H0	CXXC4_HUMAN	CXXC finger protein 4	121					negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway|zygotic specification of dorsal/ventral axis		DNA binding|PDZ domain binding|zinc ion binding	p.S120A(1)		kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	11				OV - Ovarian serous cystadenocarcinoma(123;3.05e-08)		TGAGGAGGACGAGGAGGAGGAGG	0.606													7	75	---	---	---	---					
NUDT12	83594	broad.mit.edu	37	5	102891701	102891702	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:102891701_102891702insA	ENST00000230792.2	-	4	990_991	c.894_895insT	c.(892-897)taagagfs	p.*E298fs	NUDT12_ENST00000507423.1_Frame_Shift_Ins_p.*E280fs|NUDT12_ENST00000515407.1_5'UTR	NM_031438.2	NP_113626.1	Q9BQG2	NUD12_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 12	298						nucleus|peroxisome	metal ion binding|NAD+ diphosphatase activity			endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(6)|urinary_tract(1)	12		all_cancers(142;6.38e-08)|all_epithelial(76;1.99e-10)|Prostate(80;0.0138)|Lung NSC(167;0.0212)|Colorectal(57;0.0247)|all_lung(232;0.0283)|Ovarian(225;0.0423)		Epithelial(69;9.3e-13)|COAD - Colon adenocarcinoma(37;0.0221)		CATAATCTCTTATAGCCACCTT	0.416													14	51	---	---	---	---					
FBN2	2201	broad.mit.edu	37	5	127597566	127597566	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr5:127597566delC	ENST00000508053.1	-	70	9200	c.8226delG	c.(8224-8226)ggfs	p.G2742fs	FBN2_ENST00000262464.4_Frame_Shift_Del_p.G2742fs			P35556	FBN2_HUMAN	fibrillin 2	2742					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ACAGGTACTGCCCCTTGTTAA	0.433													25	131	---	---	---	---					
SSPO	23145	broad.mit.edu	37	7	149522109	149522110	+	RNA	INS	-	-	G			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:149522109_149522110insG	ENST00000378016.2	+	0	13896_13897							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGCCCTGCAGTGGGGGGTTCAG	0.653													4	6	---	---	---	---					
GIMAP5	55340	broad.mit.edu	37	7	150439450	150439450	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr7:150439450delG	ENST00000358647.3	+	3	590	c.223delG	c.(223-225)ggfs	p.G75fs	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AACATGGAACGGGAGGAAAGT	0.572													20	64	---	---	---	---					
CHRM1	1128	broad.mit.edu	37	11	62678152	62678152	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr11:62678152delG	ENST00000306960.3	-	2	962	c.421delC	c.(421-423)ggfs	p.R141fs	AP000438.2_ENST00000543624.1_RNA	NM_000738.2	NP_000729.2	P11229	ACM1_HUMAN	cholinergic receptor, muscarinic 1	141					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell proliferation|nervous system development|positive regulation of cell proliferation|protein modification process	cell junction|integral to plasma membrane|membrane fraction|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity|protein binding			large_intestine(5)|lung(3)|stomach(1)	9					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Benztropine(DB00245)|Bethanechol(DB01019)|Biperiden(DB00810)|Buclizine(DB00354)|Carbachol(DB00411)|Carbinoxamine(DB00748)|Cevimeline(DB00185)|Clidinium(DB00771)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Cyclopentolate(DB00979)|Cycrimine(DB00942)|Desipramine(DB01151)|Dicyclomine(DB00804)|Diphenidol(DB01231)|Doxylamine(DB00366)|Ethopropazine(DB00392)|Flavoxate(DB01148)|Glycopyrrolate(DB00986)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methantheline(DB00940)|Methotrimeprazine(DB01403)|Methylscopolamine(DB00462)|Metixene(DB00340)|Metoclopramide(DB01233)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Oxyphenonium(DB00219)|Pilocarpine(DB01085)|Pirenzepine(DB00670)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propantheline(DB00782)|Propiomazine(DB00777)|Quinacrine(DB01103)|Scopolamine(DB00747)|Solifenacin(DB01591)|Succinylcholine(DB00202)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)|Trihexyphenidyl(DB00376)|Trospium(DB00209)	AGAGCTGCCCGGCGGGGTGTG	0.627													33	49	---	---	---	---					
ZNF232	7775	broad.mit.edu	37	17	5009460	5009461	+	Frame_Shift_Del	DEL	TA	TA	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr17:5009460_5009461delTA	ENST00000250076.3	-	5	1647_1648	c.993_994delTA	c.(991-996)taagfs	p.YK331fs	ZNF232_ENST00000575898.1_Frame_Shift_Del_p.YK322fs|ZNF232_ENST00000416429.2_3'UTR	NM_014519.2	NP_055334.2	Q9UNY5	ZN232_HUMAN	zinc finger protein 232	304					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|ovary(1)|prostate(2)	11						TCACTACACTTATAGGGTTTCT	0.411													35	133	---	---	---	---					
RP11-683L23.1	0	broad.mit.edu	37	18	47752	47752	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr18:47752delC	ENST00000573909.1	-	3	1403	c.871delG	c.(871-873)agfs	p.E291fs	RP11-683L23.1_ENST00000308911.6_Frame_Shift_Del_p.E325fs																							TCATCCACCTCCCTCATGGGC	0.517													33	118	---	---	---	---					
LILRA6	79168	broad.mit.edu	37	19	54742915	54742915	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chr19:54742915delC	ENST00000396365.2	-	8	1399	c.1360delG	c.(1360-1362)cafs	p.A454fs	LILRB3_ENST00000407860.2_Intron|LILRA6_ENST00000419410.2_Intron|LILRA6_ENST00000270464.5_Intron|LILRA6_ENST00000440558.2_Intron|LILRA6_ENST00000245621.5_Frame_Shift_Del_p.A437fs|LILRA6_ENST00000391735.3_Intron	NM_024318.2	NP_077294.2			leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACCAAGCCTGCCATGCCCATG	0.572													16	81	---	---	---	---					
RP13-228J13.1	0	broad.mit.edu	37	X	154578865	154578865	+	RNA	DEL	G	G	-	rs150846040	by1000genomes	TCGA-55-8203-01A-11D-2238-08	TCGA-55-8203-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9c45b38b-d33c-48cb-98f0-701bb0c76520	07e3f6f8-8e0e-468d-8c38-a8201e0c5474	g.chrX:154578865delG	ENST00000412436.1	-	0	98				RP13-228J13.5_ENST00000453508.1_RNA|RP13-228J13.1_ENST00000444722.1_RNA																							TTTTCTCTCTGTTTTTTTTTT	0.418													2	4	---	---	---	---					
