Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
WWTR1	25937	broad.mit.edu	37	3	149290690	149290690	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:149290690C>A	ENST00000465804.1	-	4	785	c.529G>T	c.(529-531)Gtg>Ttg	p.V177L	WWTR1_ENST00000360632.3_Missense_Mutation_p.V177L|WWTR1_ENST00000467467.1_Missense_Mutation_p.V177L	NM_001168278.1	NP_001161750.1	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	177					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	23			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			CTCTGAGGCACTGGTGTGGAA	0.438000			T	CAMTA1	epitheliod hemangioendothelioma								23	73					1.33986e-20	2.36352e-20	1	1	0
UHRF1	29128	broad.mit.edu	37	19	4954431	4954431	+	RNA	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:4954431G>A	ENST00000592666.1	+	0	2464							Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains 1						cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|upper_aerodigestive_tract(2)	16				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		GAGGGAGGAGGAGGAGCAGCA	0.627000													4	28					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090479	9090479	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:9090479C>A	ENST00000397910.4	-	1	1539	c.1336G>T	c.(1336-1338)Gga>Tga	p.G446*		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	446	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GACTCTTCTCCAGGAGCAGAG	0.483000													48	113					3.61183e-13	5.51147e-13	1	1	0
SETD1A	9739	broad.mit.edu	37	16	30991893	30991893	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:30991893A>G	ENST00000262519.8	+	15	5182	c.4496A>G	c.(4495-4497)tAc>tGc	p.Y1499C		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	1499	Interaction with ASH2L, RBBP5 and WDR5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						AGCGAAGGCTACTACCCCATC	0.652000													32	116					0	0	1	0	0
SSTR4	6754	broad.mit.edu	37	20	23016580	23016580	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:23016580G>C	ENST00000255008.3	+	1	524	c.460G>C	c.(460-462)Gcg>Ccg	p.A154P	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	154					G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCCTCTGCGCGCGGCGACCTA	0.662000													6	90					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73067574	73067574	+	RNA	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:73067574G>C	ENST00000429829.1	-	0	5014					NR_001564.2																						TGGATAATTAGAAATACACAT	0.338000													8	33					0	0	1	0	0
GSG1	83445	broad.mit.edu	37	12	13237958	13237958	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:13237958G>T	ENST00000337630.6	-	6	925	c.858C>A	c.(856-858)ccC>ccA	p.P286P	GSG1_ENST00000432710.2_Silent_p.P299P|GSG1_ENST00000457134.2_Silent_p.P235P|GSG1_ENST00000324458.8_Silent_p.P322P|GSG1_ENST00000351606.6_3'UTR|GSG1_ENST00000537302.1_Silent_p.P258P|GSG1_ENST00000396302.3_3'UTR|GSG1_ENST00000396310.2_Silent_p.P255P	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	309						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		CAGAGTGGATGGGCTGATTAT	0.552000													7	12					0.0293803	0.0304864	1	1	0
SYMPK	8189	broad.mit.edu	37	19	46345518	46345518	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:46345518C>G	ENST00000245934.7	-	9	1321	c.1077G>C	c.(1075-1077)aaG>aaC	p.K359N		NM_004819.2	NP_004810.2	Q92797	SYMPK_HUMAN	symplekin	359					cell adhesion|mRNA processing	cytoplasm|cytoskeleton|nucleoplasm|tight junction	protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(25)|ovary(1)|urinary_tract(1)	45		all_neural(266;0.0299)|Ovarian(192;0.0308)		OV - Ovarian serous cystadenocarcinoma(262;0.00509)|GBM - Glioblastoma multiforme(486;0.0593)		CCAGCTTCATCTTCTTGAGTG	0.547000													12	108					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24491719	24491719	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:24491719C>G	ENST00000264463.4	-	11	2349	c.1842G>C	c.(1840-1842)ttG>ttC	p.L614F	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	614					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GGATGGCGATCAAGGCCCCAG	0.498000										HNSCC(23;0.051)			49	125					0	0	1	0	0
ZDHHC6	64429	broad.mit.edu	37	10	114200367	114200367	+	Silent	SNP	T	T	A	rs17129779	byFrequency	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:114200367T>A	ENST00000369405.3	-	5	1029	c.606A>T	c.(604-606)gcA>gcT	p.A202A	ZDHHC6_ENST00000369404.3_Silent_p.A198A	NM_022494.1	NP_071939.1	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	202						integral to membrane	acyltransferase activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		TGGTAGCAAATGCAGCTAATC	0.453000													17	115					0	0	1	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95457399	95457399	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:95457399G>T	ENST00000324972.6	+	5	589	c.396G>T	c.(394-396)gtG>gtT	p.V132V	DYNC1I1_ENST00000537881.1_Intron|DYNC1I1_ENST00000359388.4_Intron|DYNC1I1_ENST00000457059.1_Silent_p.V115V|DYNC1I1_ENST00000447467.2_Silent_p.V115V|DYNC1I1_ENST00000437599.1_Intron	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	132					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			ACCCCTCAGTGCTCCAGCTGC	0.443000													65	324					1.48005e-37	2.83783e-37	1	1	0
CASP5	838	broad.mit.edu	37	11	104877898	104877898	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:104877898C>A	ENST00000393141.2	-	3	415	c.384G>T	c.(382-384)ttG>ttT	p.L128F	CASP5_ENST00000531367.1_Intron|CASP5_ENST00000393139.2_Missense_Mutation_p.L82F|CASP5_ENST00000418434.1_Intron|CASP5_ENST00000260315.3_Missense_Mutation_p.L115F|CASP5_ENST00000444749.2_Missense_Mutation_p.L57F|CASP5_ENST00000526056.1_Missense_Mutation_p.L128F	NM_001136112.1|NM_004347.3	NP_001129584.1|NP_004338.3	P51878	CASP5_HUMAN	caspase 5, apoptosis-related cysteine peptidase	115	CARD.				apoptosis|cellular response to mechanical stimulus|proteolysis|regulation of apoptosis	intracellular	cysteine-type endopeptidase activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|ovary(3)|skin(1)|urinary_tract(1)	35		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Melanoma(852;0.0047)		BRCA - Breast invasive adenocarcinoma(274;0.000943)|Epithelial(105;0.0104)|all cancers(92;0.042)		AAGAGTCTACCAAGATCAGGG	0.368000													13	129					4.3838e-07	5.4922e-07	1	1	0
NKAP	79576	broad.mit.edu	37	X	119077528	119077528	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:119077528G>T	ENST00000371410.3	-	1	207	c.41C>A	c.(40-42)gCc>gAc	p.A14D		NM_024528.3	NP_078804.2	Q8N5F7	NKAP_HUMAN	NFKB activating protein	14	Ser-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)	20						CGAGCCCGAGGCCTCCCTATC	0.706000													4	44					0.0215528	0.0225231	1	1	0
ZMIZ2	83637	broad.mit.edu	37	7	44801481	44801481	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:44801481A>G	ENST00000309315.4	+	11	1696	c.1573A>G	c.(1573-1575)Atc>Gtc	p.I525V	ZMIZ2_ENST00000441627.1_Missense_Mutation_p.I525V|ZMIZ2_ENST00000413916.1_Missense_Mutation_p.I467V|ZMIZ2_ENST00000265346.7_Missense_Mutation_p.I499V|ZMIZ2_ENST00000433667.1_Missense_Mutation_p.I493V	NM_031449.3	NP_113637.3	Q8NF64	ZMIZ2_HUMAN	zinc finger, MIZ-type containing 2	525					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear replication fork	ligand-dependent nuclear receptor transcription coactivator activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CACCATCCAGATCACCGTCAC	0.687000													10	48					0	0	1	0	0
DIS3L	115752	broad.mit.edu	37	15	66618430	66618430	+	Silent	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:66618430A>T	ENST00000319194.5	+	12	1941	c.1680A>T	c.(1678-1680)cgA>cgT	p.R560R	DIS3L_ENST00000319212.4_Silent_p.R643R|RP11-352G18.2_ENST00000565993.1_RNA	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like	643					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GAGCTAAACGAGACGGATGTG	0.522000													31	116					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	163251	163251	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:163251G>C	ENST00000283426.6	+	11	2046	c.1996G>C	c.(1996-1998)Gac>Cac	p.D666H		NM_052909.3	NP_443141.3	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4B	666					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		GTGTGGACAGGACGGGGAGAC	0.692000													3	23					0	0	1	0	0
KRT14	3861	broad.mit.edu	37	17	39742668	39742668	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:39742668T>C	ENST00000167586.6	-	1	505	c.419A>G	c.(418-420)aAc>aGc	p.N140S		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	140	Coil 1A.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				CAGGTCGGCGTTGGCCTCCTC	0.582000													57	189					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101018337	101018337	+	Splice_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:101018337C>A	ENST00000360863.6	-	16	2556	c.2361_splice	c.e16-1	p.V788_splice	RGS22_ENST00000523287.1_Splice_Site_p.V607_splice|RGS22_ENST00000523437.1_Splice_Site_p.V776_splice|RGS22_ENST00000519421.1_5'UTR	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	788					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ACCAGCTCCACCTAAAAAAAA	0.368000													8	32					0.0381472	0.0393059	1	1	0
PRR21	643905	broad.mit.edu	37	2	240982119	240982119	+	Missense_Mutation	SNP	G	G	T	rs71420284		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:240982119G>T	ENST00000408934.1	-	1	280	c.281C>A	c.(280-282)cCa>cAa	p.P94Q		NM_001080835.1	NP_001074304.1	Q8WXC7	PRR21_HUMAN	proline rich 21	94	Pro-rich.							p.S86fs*291(2)		NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(5)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	29						GAAGGGCCGTGGGTGAAGAGG	0.612000													19	48					7.45023e-12	1.08434e-11	1	1	0
GRIN2B	2904	broad.mit.edu	37	12	14019061	14019061	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:14019061A>T	ENST00000279593.3	-	2	291	c.82T>A	c.(82-84)Tct>Act	p.S28T		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	28					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CTCTTCTGAGAACGAGCTCTG	0.582000													27	49					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24922199	24922199	+	Silent	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:24922199C>G	ENST00000329468.2	+	1	1659	c.1185C>G	c.(1183-1185)acC>acG	p.T395T		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GCAGCATCACCCAGCCTGCCC	0.522000													10	54					0	0	1	0	0
SEMA3G	56920	broad.mit.edu	37	3	52476764	52476764	+	Splice_Site	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:52476764T>A	ENST00000231721.2	-	2	274	c.276_splice	c.e2+1	p.E92_splice		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	92	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		CCAGCTCACCTCCCGGGGATC	0.617000													8	15					0	0	1	0	0
NAALAD2	10003	broad.mit.edu	37	11	89868777	89868777	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:89868777C>T	ENST00000534061.1	+	2	363	c.133C>T	c.(133-135)Caa>Taa	p.Q45*	NAALAD2_ENST00000321955.4_Nonsense_Mutation_p.Q45*|NAALAD2_ENST00000375944.3_Nonsense_Mutation_p.Q45*|NAALAD2_ENST00000525171.1_Nonsense_Mutation_p.Q45*	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	45					proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GCGCTATCATCAAAGTATACG	0.338000													13	65					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57405083	57405083	+	Splice_Site	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:57405083G>T	ENST00000374900.4	+	6	862		c.e6-1			NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2							integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						TATCCTTTCAGGTGTGGTTCC	0.463000										HNSCC(52;0.14)			27	89					2.48779e-11	3.52771e-11	1	1	0
MAST4	375449	broad.mit.edu	37	5	66462681	66462681	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:66462681G>T	ENST00000404260.3	+	29	7991	c.7683G>T	c.(7681-7683)ggG>ggT	p.G2561G	MAST4_ENST00000261569.7_Silent_p.G2364G|MAST4_ENST00000403666.1_Silent_p.G2369G|MAST4_ENST00000405643.1_Silent_p.G2379G|MAST4_ENST00000403625.2_Silent_p.G2558G			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	2561						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCACCGTAGGGGAAACCAAAG	0.657000													4	10					1	1	1	1	0
OR8K5	219453	broad.mit.edu	37	11	55927072	55927072	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:55927072C>A	ENST00000313447.1	-	1	721	c.722G>T	c.(721-723)tGt>tTt	p.C241F		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				ATGGGAACCACATGTGGAGAA	0.418000													13	79					9.31168e-06	1.12815e-05	1	1	0
ASB1	51665	broad.mit.edu	37	2	239353045	239353045	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:239353045G>T	ENST00000264607.4	+	4	804	c.557G>T	c.(556-558)cGg>cTg	p.R186L	ASB1_ENST00000409297.1_Missense_Mutation_p.R85L	NM_001040445.1	NP_001035535.1	Q9Y576	ASB1_HUMAN	ankyrin repeat and SOCS box containing 1	186					intracellular signal transduction|negative regulation of cytokine biosynthetic process					breast(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	8		all_epithelial(40;2.65e-14)|Breast(86;7.61e-05)|Renal(207;0.00183)|all_lung(227;0.0283)|Ovarian(221;0.0365)|Lung NSC(271;0.0941)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;4.5e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.5e-08)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)		CGATTCTCCCGGCGGCTCACC	0.612000													12	54					1.08611e-07	1.39236e-07	1	1	0
SLC25A47	283600	broad.mit.edu	37	14	100795206	100795206	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:100795206C>A	ENST00000361529.3	+	5	549	c.471C>A	c.(469-471)ccC>ccA	p.P157P	SLC25A47_ENST00000557052.1_Silent_p.P11P	NM_207117.2	NP_997000.2	Q6Q0C1	S2547_HUMAN	solute carrier family 25, member 47	157					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	13						GCCCAGAGCCCAAGTACCGCG	0.706000													12	31					3.07112e-06	3.76212e-06	1	1	0
DGKB	1607	broad.mit.edu	37	7	14789761	14789761	+	Silent	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:14789761G>C	ENST00000258767.5	-	3	351	c.165C>G	c.(163-165)ggC>ggG	p.G55G	DGKB_ENST00000403951.2_Intron|DGKB_ENST00000444700.2_Intron|DGKB_ENST00000402815.1_Intron|DGKB_ENST00000403963.1_Intron|DGKB_ENST00000407950.1_Intron|DGKB_ENST00000406247.3_Intron|DGKB_ENST00000399322.3_Intron			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	55					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	tccttaaattgcccaacacca	0.313000													4	24					0	0	1	0	0
SPRY1	10252	broad.mit.edu	37	4	124323206	124323206	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:124323206A>G	ENST00000394339.2	+	2	800	c.460A>G	c.(460-462)Atc>Gtc	p.I154V	SPRY1_ENST00000339241.1_Missense_Mutation_p.I154V	NM_001258039.1|NM_005841.2	NP_001244968.1|NP_005832.1	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling (Drosophila)	154					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				NS(1)|large_intestine(4)|lung(2)|ovary(1)|skin(3)	11						TGAAAGGGCAATCCGGACCCA	0.527000													9	72					0	0	1	0	0
SLC37A1	54020	broad.mit.edu	37	21	43955581	43955581	+	Splice_Site	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr21:43955581G>C	ENST00000352133.2	+	5	1253		c.e5-1		SLC37A1_ENST00000398341.3_Splice_Site			P57057	GLPT_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 1						carbohydrate transport|transmembrane transport	integral to membrane				breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|liver(2)|lung(3)	15						AATTCATATAGATAAGAACAA	0.468000													10	106					0	0	1	0	0
KIN	22944	broad.mit.edu	37	10	7801865	7801865	+	Silent	SNP	G	G	A	rs144499188		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:7801865G>A	ENST00000379562.3	-	12	1154	c.1107C>T	c.(1105-1107)atC>atT	p.I369I	KIN_ENST00000543003.1_Silent_p.I263I|KIN_ENST00000463666.1_5'UTR|KIN_ENST00000535925.1_Silent_p.I369I			O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)	369	C-terminal subdomain B.				DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						TTTCAATGACGATAGTAGCTG	0.303000													8	48					0	0	1	0	0
KLB	152831	broad.mit.edu	37	4	39408733	39408733	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:39408733G>C	ENST00000257408.4	+	1	261	c.164G>C	c.(163-165)gGa>gCa	p.G55A		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	55					carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						GGATTCTCTGGAGATGGAAGA	0.408000													13	116					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1317534	1317534	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:1317534G>T	ENST00000381567.3	-	5	530	c.531C>A	c.(529-531)gcC>gcA	p.A177A	CRLF2_ENST00000467626.1_Intron	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	177	Fibronectin type-III.					extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				AACACTTCTCGGCATCCAAGC	0.493000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								18	55					1.99824e-07	2.54688e-07	1	1	0
GRIK3	2899	broad.mit.edu	37	1	37291324	37291324	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:37291324C>A	ENST00000373091.3	-	11	1650	c.1634G>T	c.(1633-1635)cGa>cTa	p.R545L	GRIK3_ENST00000373093.4_Missense_Mutation_p.R545L	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	545					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	ATTGGGCTTTCGATACAGGAT	0.572000													15	98					1.3612e-06	1.68621e-06	1	1	0
TBCEL	219899	broad.mit.edu	37	11	120918293	120918293	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:120918293G>T	ENST00000422003.2	+	3	378	c.190G>T	c.(190-192)Gga>Tga	p.G64*	TBCEL_ENST00000529397.1_Nonsense_Mutation_p.G64*	NM_152715.3	NP_689928.3	Q5QJ74	TBCEL_HUMAN	tubulin folding cofactor E-like	64						cytoplasm|cytoskeleton			TECTA/TBCEL(2)	endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		Breast(109;0.00526)|Medulloblastoma(222;0.0523)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;5.89e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.121)		AACCTGTGCAGGAGATGAAAA	0.408000													30	98					4.74835e-14	7.47866e-14	1	1	0
CADM2	253559	broad.mit.edu	37	3	86115850	86115850	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:86115850G>T	ENST00000383699.3	+	10	1759	c.1132G>T	c.(1132-1134)Gat>Tat	p.D378Y	CADM2_ENST00000405615.2_Missense_Mutation_p.D411Y|CADM2_ENST00000407528.2_Missense_Mutation_p.D409Y	NM_001167675.1|NM_001256504.1|NM_001256505.1	NP_001161147.1|NP_001243433.1|NP_001243434.1	Q8N3J6	CADM2_HUMAN	cell adhesion molecule 2	409					adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(1)|prostate(1)|skin(4)	38		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		AGGAGCTGAAGATGCACCAGA	0.383000													33	56					6.50621e-10	8.85568e-10	1	1	0
BPIFB4	149954	broad.mit.edu	37	20	31671491	31671491	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:31671491C>A	ENST00000375483.3	+	3	488	c.488C>A	c.(487-489)aCt>aAt	p.T163N		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	163	Gly-rich.					cytoplasm|extracellular region	lipid binding										GGAGTTGCCACTGGGGCGGTG	0.672000													21	51					7.45023e-12	1.08434e-11	1	1	0
MYO18B	84700	broad.mit.edu	37	22	26422733	26422733	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr22:26422733G>T	ENST00000335473.7	+	43	7043	c.6793G>T	c.(6793-6795)Ggc>Tgc	p.G2265C	MYO18B_ENST00000407587.2_Missense_Mutation_p.G2266C|MYO18B_ENST00000536101.1_Missense_Mutation_p.G2265C	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2265						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGCCCAGAGAGGCCAGGGGTC	0.632000													8	19					0.00307968	0.00332877	1	1	0
RABL6	55684	broad.mit.edu	37	9	139733732	139733732	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr9:139733732C>A	ENST00000371675.3	+	12	2092	c.1207C>A	c.(1207-1209)Ccc>Acc	p.P403T	RABL6_ENST00000357466.2_Intron|RABL6_ENST00000311502.7_Missense_Mutation_p.P518T|RABL6_ENST00000432842.2_Intron|RABL6_ENST00000371663.4_Missense_Mutation_p.P519T					RAB, member RAS oncogene family-like 6																		GACCGCAGCACCCCCCTGGCC	0.667000													6	8					0.0215528	0.0225231	1	1	0
ZC3H13	23091	broad.mit.edu	37	13	46553965	46553965	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr13:46553965C>A	ENST00000242848.4	-	11	2243	c.1895G>T	c.(1894-1896)cGt>cTt	p.R632L	ZC3H13_ENST00000282007.3_Missense_Mutation_p.R632L			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	632	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTGTTGTCACGACGGTCTCG	0.373000													24	120					6.44725e-10	8.80259e-10	1	1	0
TEKT3	64518	broad.mit.edu	37	17	15222466	15222466	+	Splice_Site	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:15222466T>A	ENST00000395930.1	-	5	850		c.e5-2		TEKT3_ENST00000338696.2_Splice_Site	NM_031898.2	NP_114104.1	Q9BXF9	TEKT3_HUMAN	tektin 3						microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				endometrium(1)|kidney(3)|large_intestine(5)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	23				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		ATCAACTTCCTACTCAATTGG	0.294000													15	43					0	0	1	0	0
DIS3L	115752	broad.mit.edu	37	15	66618429	66618429	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:66618429G>T	ENST00000319194.5	+	12	1940	c.1679G>T	c.(1678-1680)cGa>cTa	p.R560L	DIS3L_ENST00000319212.4_Missense_Mutation_p.R643L|RP11-352G18.2_ENST00000565993.1_RNA	NM_133375.3	NP_588616.1	Q8TF46	DI3L1_HUMAN	DIS3 mitotic control homolog (S. cerevisiae)-like	643					rRNA catabolic process	cytoplasm|exosome (RNase complex)	exonuclease activity|protein binding|ribonuclease activity|RNA binding			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AGAGCTAAACGAGACGGATGT	0.517000													31	111					1.30897e-18	2.25491e-18	1	1	0
ACAN	176	broad.mit.edu	37	15	89383305	89383305	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:89383305C>T	ENST00000439576.2	+	4	891	c.517C>T	c.(517-519)Cgg>Tgg	p.R173W	ACAN_ENST00000558207.1_Missense_Mutation_p.R173W|ACAN_ENST00000559004.1_Missense_Mutation_p.R173W|ACAN_ENST00000561243.1_Missense_Mutation_p.R173W|ACAN_ENST00000352105.7_Missense_Mutation_p.R173W	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	173					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CAGGGCGCAGCGGGCCTGCCT	0.612000													3	13					0	0	1	0	0
C2orf71	388939	broad.mit.edu	37	2	29294021	29294021	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:29294021G>T	ENST00000331664.5	-	1	3106	c.3107C>A	c.(3106-3108)cCc>cAc	p.P1036H		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	1036	Pro-rich.				response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						TAGCACCCTGGGGCTCACAGG	0.662000													15	62					6.72482e-11	9.38496e-11	1	1	0
OR8J1	219477	broad.mit.edu	37	11	56128647	56128647	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:56128647C>T	ENST00000303039.3	+	1	957	c.925C>T	c.(925-927)Ctg>Ttg	p.L309L		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					CATGACAAATCTGTGCTATTC	0.348000													11	61					0	0	1	0	0
ZDHHC9	51114	broad.mit.edu	37	X	128962956	128962956	+	Splice_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:128962956C>A	ENST00000357166.6	-	4	720		c.e4+1		ZDHHC9_ENST00000371064.3_Splice_Site	NM_016032.3	NP_057116.2	Q9Y397	ZDHC9_HUMAN	zinc finger, DHHC-type containing 9							endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)	19						GGAAGACTCACCTATCTCCAT	0.463000													24	198					0.000295444	0.000331528	1	1	0
DNM1P47	100216544	broad.mit.edu	37	15	102294715	102294715	+	RNA	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:102294715C>T	ENST00000561463.1	+	0	2761																											AGCAGGCAGACCAAGGAGTTC	0.587000													5	10					0	0	1	0	0
LINGO1	84894	broad.mit.edu	37	15	77907883	77907883	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:77907883C>A	ENST00000355300.6	-	2	540	c.366G>T	c.(364-366)cgG>cgT	p.R122R	LINGO1_ENST00000561030.1_Silent_p.R116R	NM_032808.5	NP_116197.4	Q96FE5	LIGO1_HUMAN	leucine rich repeat and Ig domain containing 1	122					negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	31						GACCCAGCGTCCGGAGGTTGA	0.617000													5	26					1	1	1	1	0
FAM71B	153745	broad.mit.edu	37	5	156592893	156592893	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:156592893C>A	ENST00000302938.4	-	1	382	c.287G>T	c.(286-288)tGt>tTt	p.C96F		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	96						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATGCTGTTCACAGATTTTAGT	0.557000													32	68					2.61193e-14	4.14339e-14	1	1	0
RYR2	6262	broad.mit.edu	37	1	237947090	237947090	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:237947090G>T	ENST00000366574.2	+	90	12395	c.12078G>T	c.(12076-12078)ttG>ttT	p.L4026F	RYR2_ENST00000360064.6_Missense_Mutation_p.L4032F|RYR2_ENST00000542537.1_Missense_Mutation_p.L4010F	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4026	EF-hand.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TAAAGGATTTGACGTCGTCTG	0.423000													10	33					7.48243e-07	9.32133e-07	1	1	0
CR1	1378	broad.mit.edu	37	1	207679402	207679402	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:207679402G>T	ENST00000367049.4	+	2	275	c.275G>T	c.(274-276)tGg>tTg	p.W92L	CR1_ENST00000400960.2_Missense_Mutation_p.W92L|CR1_ENST00000367052.1_Missense_Mutation_p.W92L|CR1_ENST00000367051.1_Missense_Mutation_p.W92L|CR1_ENST00000367053.1_Missense_Mutation_p.W92L|CR1_ENST00000367050.4_3'UTR	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	92	Sushi 1.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						AACTCAGTCTGGACTGGTGCT	0.428000													32	184					1.36615e-20	2.40028e-20	1	1	0
SLC18A1	6570	broad.mit.edu	37	8	20004768	20004768	+	Splice_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:20004768C>A	ENST00000440926.1	-	16	1935		c.e16+1		SLC18A1_ENST00000381608.4_Intron|SLC18A1_ENST00000276373.5_Splice_Site|SLC18A1_ENST00000437980.1_Intron|SLC18A1_ENST00000265808.7_Splice_Site|SLC18A1_ENST00000519026.1_Splice_Site	NM_001135691.2	NP_001129163.1	P54219	VMAT1_HUMAN	solute carrier family 18 (vesicular monoamine transporter), member 1						neurotransmitter transport	clathrin sculpted monoamine transport vesicle membrane|integral to membrane|membrane fraction	drug transmembrane transporter activity|monoamine transmembrane transporter activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29				Colorectal(74;0.0747)		GTGCTCCTTACAAGCTTCTCT	0.493000													7	40					2.0095e-06	2.47539e-06	1	1	0
OSBPL6	114880	broad.mit.edu	37	2	179248840	179248840	+	Silent	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:179248840A>T	ENST00000190611.4	+	18	2326	c.1950A>T	c.(1948-1950)ccA>ccT	p.P650P	OSBPL6_ENST00000359685.3_Silent_p.P614P|OSBPL6_ENST00000315022.2_Silent_p.P654P|OSBPL6_ENST00000409045.3_Silent_p.P619P|OSBPL6_ENST00000409631.1_Silent_p.P614P|OSBPL6_ENST00000392505.2_Silent_p.P675P	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	650					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CATTCAACCCAGTCCTTGGGG	0.448000													82	325					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54844917	54844917	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:54844917T>A	ENST00000291759.4	-	8	1482	c.1426A>T	c.(1426-1428)Agg>Tgg	p.R476W	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	476						integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TGGCTGCACCTTGGGGGGCTT	0.552000													14	49					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559586	140559586	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:140559586C>A	ENST00000239444.2	+	1	2216	c.1971C>A	c.(1969-1971)gcC>gcA	p.A657A		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		657	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGGCCACCGCCACGCTGCACT	0.701000													20	70					2.41591e-17	4.02044e-17	1	1	0
PRKCI	5584	broad.mit.edu	37	3	170016797	170016797	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:170016797G>T	ENST00000295797.4	+	17	1907	c.1602G>T	c.(1600-1602)caG>caT	p.Q534H		NM_002740.5	NP_002731.4	P41743	KPCI_HUMAN	protein kinase C, iota	534	AGC-kinase C-terminal.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	36	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			AGCAAAAACAGGTGGTACCTC	0.413000													10	38					3.86212e-05	4.49392e-05	1	1	0
CACNA2D4	93589	broad.mit.edu	37	12	1963117	1963117	+	Splice_Site	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:1963117T>A	ENST00000382722.5	-	23	2608	c.2246_splice	c.e23+1	p.E749_splice	CACNA2D4_ENST00000588077.1_Splice_Site_p.E685_splice|CACNA2D4_ENST00000587995.1_Splice_Site_p.E724_splice|CACNA2D4_ENST00000585708.1_Splice_Site_p.E685_splice|CACNA2D4_ENST00000585732.1_Splice_Site_p.E610_splice|CACNA2D4_ENST00000586184.1_Splice_Site_p.E749_splice|CACNA2D4_ENST00000539048.2_Intron	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	749						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CTGGACCTACTCGGACATGTT	0.632000													8	17					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61328386	61328386	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr18:61328386G>T	ENST00000283752.5	-	2	208	c.65C>A	c.(64-66)tCa>tAa	p.S22*	SERPINB3_ENST00000332821.8_Nonsense_Mutation_p.S22*|SERPINB11_ENST00000489748.1_RNA	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	22					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						GTTCTCTTTTGATTTTCTGAA	0.433000													43	157					8.20599e-20	1.43605e-19	1	1	0
HYDIN	54768	broad.mit.edu	37	16	70896105	70896105	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:70896105G>T	ENST00000393567.2	-	69	11773	c.11623C>A	c.(11623-11625)Ctg>Atg	p.L3875M		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3875										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				GTGCTGTCCAGGGTGCTGCCT	0.562000											OREG0006524	type=TRANSCRIPTION FACTOR BINDING SITE|TFbs=REST|Dataset=NRSF/REST ChIPSeq sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	14	28					6.31663e-08	8.14512e-08	1	1	0
CEL	1056	broad.mit.edu	37	9	135940488	135940488	+	Silent	SNP	C	C	G	rs150358550	by1000genomes	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr9:135940488C>G	ENST00000372080.4	+	4	427	c.411C>G	c.(409-411)ggC>ggG	p.G137G	CEL_ENST00000351304.7_Silent_p.G134G	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	134					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		TGGGGTCCGGCCATGGGGCCA	0.632000													8	205					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103095467	103095467	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:103095467C>A	ENST00000295269.4	+	2	883	c.426C>A	c.(424-426)ggC>ggA	p.G142G		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	142					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						TTCTGGAGGGCGGCTACTTCA	0.597000													18	71					7.45023e-12	1.08434e-11	1	1	0
CDH8	1006	broad.mit.edu	37	16	61687654	61687654	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:61687654C>A	ENST00000577390.1	-	12	3212	c.2258G>T	c.(2257-2259)gGg>gTg	p.G753V	CDH8_ENST00000299345.6_Intron|CDH8_ENST00000577730.1_Intron	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	753					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AGCCACTGACCCTCGGCCTTC	0.507000													21	68					6.36457e-07	7.95121e-07	1	1	0
PSG7	5676	broad.mit.edu	37	19	43439847	43439847	+	RNA	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:43439847C>T	ENST00000406070.2	-	0	235				PSG7_ENST00000446844.3_RNA	NM_002783.2	NP_002774.2	Q13046	PSG7_HUMAN	pregnancy specific beta-1-glycoprotein 7 (gene/pseudogene)						female pregnancy	extracellular region							Prostate(69;0.00682)				TCCTTCCCCTCGGAAACTTTT	0.488000													90	202					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113668523	113668523	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:113668523G>T	ENST00000297405.5	-	18	3108	c.2864C>A	c.(2863-2865)cCa>cAa	p.P955Q	CSMD3_ENST00000343508.3_Missense_Mutation_p.P915Q|CSMD3_ENST00000455883.2_Missense_Mutation_p.P851Q|CSMD3_ENST00000352409.3_Missense_Mutation_p.P955Q	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	955	CUB 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CAGAAGATTTGGCCCATCATG	0.343000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	86					5.50884e-06	6.71104e-06	1	1	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													6	64					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	117884963	117884963	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:117884963G>A	ENST00000439649.3	-	5	891	c.524C>T	c.(523-525)aCc>aTc	p.T175I	GFRA1_ENST00000544592.1_Missense_Mutation_p.T59I|GFRA1_ENST00000369236.1_Missense_Mutation_p.T175I|GFRA1_ENST00000355422.6_Missense_Mutation_p.T180I	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	180					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		GGACACGCTGGTGGTGCACGG	0.582000													8	38					0	0	1	0	0
OR5D16	390144	broad.mit.edu	37	11	55607054	55607054	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:55607054C>A	ENST00000378396.1	+	1	827	c.827C>A	c.(826-828)gCc>gAc	p.A276D		NM_001005496.1	NP_001005496.1	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D, member 16	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A276D(1)		cervix(1)|endometrium(2)|large_intestine(4)|lung(26)|ovary(5)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	44		all_epithelial(135;0.208)				GTCAAAGTGGCCTCTGTGTTT	0.463000													5	79					0.184627	0.185892	1	1	0
THOC2	57187	broad.mit.edu	37	X	122799519	122799519	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:122799519G>T	ENST00000245838.8	-	12	1391	c.1360C>A	c.(1360-1362)Cgc>Agc	p.R454S	THOC2_ENST00000355725.4_Missense_Mutation_p.R454S|THOC2_ENST00000491737.1_Missense_Mutation_p.R339S	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	454					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						TTGCCTATGCGCACCACTTTT	0.358000													6	108					0.00198382	0.00217088	1	1	0
KIAA0430	9665	broad.mit.edu	37	16	15711344	15711344	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:15711344C>A	ENST00000396368.3	-	14	2975	c.2769G>T	c.(2767-2769)acG>acT	p.T923T	KIAA0430_ENST00000602337.1_Silent_p.T920T|KIAA0430_ENST00000540441.2_Silent_p.T758T|KIAA0430_ENST00000551742.1_Silent_p.T923T|KIAA0430_ENST00000548025.1_Silent_p.T920T|KIAA0430_ENST00000344181.3_Silent_p.T565T	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	922						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						GGATTGCGACCGTGTCTGTTA	0.488000													25	51					9.86323e-18	1.65387e-17	1	1	0
LUM	4060	broad.mit.edu	37	12	91502611	91502611	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:91502611C>T	ENST00000266718.4	-	2	600	c.146G>A	c.(145-147)aGt>aAt	p.S49N	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	49	Cys-rich.|LRRNT.				collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						GTACATGGCACTTGGGTAGCT	0.413000													9	70					0	0	1	0	0
PBDC1	51260	broad.mit.edu	37	X	75397740	75397740	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:75397740G>T	ENST00000373358.3	+	6	902	c.699G>T	c.(697-699)atG>atT	p.M233I	PBDC1_ENST00000373357.3_Missense_Mutation_p.C196F	NM_016500.3	NP_057584.2			polysaccharide biosynthesis domain containing 1																		AAAAAGCTATGTAAGGTATAC	0.393000													7	73					0.0381472	0.0393059	1	1	0
CWF19L2	143884	broad.mit.edu	37	11	107197780	107197780	+	Splice_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:107197780C>A	ENST00000282251.5	-	18	2569		c.e18-1			NM_152434.2	NP_689647.2	Q2TBE0	C19L2_HUMAN	CWF19-like 2, cell cycle control (S. pombe)								catalytic activity			endometrium(4)|kidney(2)|large_intestine(13)|lung(21)	40		Melanoma(852;1.75e-05)|all_epithelial(67;6.27e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|Breast(348;0.0258)		Epithelial(105;7.18e-06)|BRCA - Breast invasive adenocarcinoma(274;1.65e-05)|all cancers(92;1.76e-05)		CTATGATTTCCTTTTAAAGAA	0.348000													32	104					1.21669e-08	1.60647e-08	1	1	0
LRPPRC	10128	broad.mit.edu	37	2	44201883	44201883	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:44201883C>A	ENST00000260665.7	-	8	936	c.879G>T	c.(877-879)gtG>gtT	p.V293V	LRPPRC_ENST00000409946.1_Silent_p.V293V|LRPPRC_ENST00000409659.1_Silent_p.V293V	NM_133259.3	NP_573566.2	P42704	LPPRC_HUMAN	leucine-rich pentatricopeptide repeat containing	293					mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			breast(3)|endometrium(3)|kidney(5)|large_intestine(9)|lung(15)|ovary(2)|prostate(2)|skin(2)	41		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CGGACTTCTCCACCTTCTCCA	0.338000													14	62					2.32078e-09	3.09204e-09	1	1	0
CERK	64781	broad.mit.edu	37	22	47108119	47108119	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr22:47108119C>G	ENST00000216264.8	-	4	563	c.451G>C	c.(451-453)Gaa>Caa	p.E151Q	CERK_ENST00000541677.1_5'UTR	NM_022766.5	NP_073603.2	Q8TCT0	CERK1_HUMAN	ceramide kinase	151	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|ceramide metabolic process	integral to membrane of membrane fraction|membrane|nucleus	ATP binding|ceramide kinase activity|diacylglycerol kinase activity|magnesium ion binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	20		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACTTTTCTTTCATATATCCGC	0.393000													4	44					0	0	1	0	0
GABRB1	2560	broad.mit.edu	37	4	47408777	47408777	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:47408777C>A	ENST00000295454.3	+	8	1206	c.914C>A	c.(913-915)gCg>gAg	p.A305E	GABRB1_ENST00000538619.1_Missense_Mutation_p.A235E	NM_000812.3	NP_000803.2	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 1	305					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TATGTCAAAGCGATTGATATT	0.448000													8	103					1.26484e-09	1.7058e-09	1	1	0
TBX19	9095	broad.mit.edu	37	1	168282209	168282209	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:168282209G>A	ENST00000367821.3	+	8	1367	c.1316G>A	c.(1315-1317)gGg>gAg	p.G439E	TBX19_ENST00000465440.1_3'UTR	NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	439					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					GGAGCGGGTGGGCACCATTCT	0.592000													20	72					0	0	1	0	0
LYPD4	147719	broad.mit.edu	37	19	42341322	42341322	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:42341322C>A	ENST00000330743.3	-	5	1847	c.636G>T	c.(634-636)gaG>gaT	p.E212D	LYPD4_ENST00000601246.1_Missense_Mutation_p.E177D|LYPD4_ENST00000343055.4_Missense_Mutation_p.E177D	NM_173506.4	NP_775777.3	Q6UWN0	LYPD4_HUMAN	LY6/PLAUR domain containing 4	212	UPAR/Ly6.					anchored to membrane|plasma membrane				breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)	12						TGTTGAGGACCTCAGTCACTT	0.493000													104	111					6.84326e-50	1.32946e-49	1	1	0
DVL2	1856	broad.mit.edu	37	17	7132552	7132552	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:7132552T>G	ENST00000005340.5	-	8	1141	c.859A>C	c.(859-861)Aat>Cat	p.N287H	DVL2_ENST00000575458.1_Missense_Mutation_p.N281H|DVL2_ENST00000574642.1_5'UTR	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	287	PDZ.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						CCCCGCTCATTGCTCTGGCCA	0.592000													39	73					0	0	1	0	0
SETD1A	9739	broad.mit.edu	37	16	30991895	30991895	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:30991895T>A	ENST00000262519.8	+	15	5184	c.4498T>A	c.(4498-4500)Tac>Aac	p.Y1500N		NM_014712.1	NP_055527.1	O15047	SET1A_HUMAN	SET domain containing 1A	1500	Interaction with ASH2L, RBBP5 and WDR5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(21)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	59						CGAAGGCTACTACCCCATCAG	0.662000													34	115					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197896830	197896830	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:197896830C>T	ENST00000367390.3	+	5	843	c.816C>T	c.(814-816)acC>acT	p.T272T	LHX9_ENST00000367391.1_Silent_p.T272T|LHX9_ENST00000561173.1_Silent_p.T287T|LHX9_ENST00000367387.4_Silent_p.T281T|LHX9_ENST00000337020.2_Silent_p.T281T	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	281					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						AGCTCCGGACCATGAAATCCT	0.532000													80	151					0	0	1	0	0
DPH1	1801	broad.mit.edu	37	17	1943821	1943821	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:1943821C>T	ENST00000263083.6	+	9	989	c.944C>T	c.(943-945)gCc>gTc	p.A315V	DPH1_ENST00000570477.1_Missense_Mutation_p.A235V	NM_001383.3	NP_001374.3	Q9BZG8	DPH1_HUMAN	diphthamide biosynthesis 1	315					peptidyl-diphthamide biosynthetic process from peptidyl-histidine|translation	cytoplasm|nucleus				endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	17						CGACTCCGAGCCTTGGGCCTT	0.567000													20	64					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92979283	92979283	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:92979283G>T	ENST00000544910.1	+	26	2531	c.2311G>T	c.(2311-2313)Gtg>Ttg	p.V771L	CCDC132_ENST00000474412.1_3'UTR|CCDC132_ENST00000535481.1_Missense_Mutation_p.V521L|CCDC132_ENST00000305866.5_Missense_Mutation_p.V801L|CCDC132_ENST00000541136.1_3'UTR	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	801										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			CATGGCTAATGTGAAATGGGA	0.408000													18	98					5.01169e-05	5.8162e-05	1	1	0
KTN1	3895	broad.mit.edu	37	14	56103206	56103206	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:56103206C>G	ENST00000416613.1	+	9	1573	c.1501C>G	c.(1501-1503)Cag>Gag	p.Q501E	KTN1_ENST00000438792.2_Missense_Mutation_p.Q501E|KTN1_ENST00000395314.3_Missense_Mutation_p.Q501E|KTN1_ENST00000413890.2_Missense_Mutation_p.Q501E|KTN1_ENST00000395311.1_Missense_Mutation_p.Q501E|KTN1_ENST00000395309.3_Missense_Mutation_p.Q501E|KTN1_ENST00000395308.1_Missense_Mutation_p.Q501E			Q86UP2	KTN1_HUMAN	kinectin 1 (kinesin receptor)	501					microtubule-based movement	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction				breast(4)|central_nervous_system(1)|large_intestine(8)|lung(1)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	19						GGAAGAAGTTCAGAGCTACAT	0.373000			T	RET	papillary thryoid								6	20					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47976516	47976516	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:47976516A>C	ENST00000543600.1	-	2	749	c.710T>G	c.(709-711)aTg>aGg	p.M237R	PTCHD4_ENST00000339488.4_Missense_Mutation_p.M254R			Q6ZW05	CF138_HUMAN	patched domain containing 4	254	SSD.					integral to membrane	hedgehog receptor activity										GCAGTCCTTCATGGAGCTGGA	0.572000													14	33					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32811925	32811925	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr13:32811925A>G	ENST00000380250.3	+	44	6716	c.6220A>G	c.(6220-6222)Atg>Gtg	p.M2074V		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	2074					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		ACTGGCACATATGCCACTCGA	0.517000													7	70					0	0	1	0	0
NVL	4931	broad.mit.edu	37	1	224488275	224488275	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:224488275C>A	ENST00000281701.6	-	10	1310	c.1051G>T	c.(1051-1053)Gag>Tag	p.E351*	NVL_ENST00000469075.1_Nonsense_Mutation_p.E260*|NVL_ENST00000482491.1_Nonsense_Mutation_p.E75*|NVL_ENST00000391875.2_Nonsense_Mutation_p.E245*|NVL_ENST00000340871.4_Nonsense_Mutation_p.E162*|NVL_ENST00000361463.3_Nonsense_Mutation_p.E245*	NM_002533.3	NP_002524.2	O15381	NVL_HUMAN	nuclear VCP-like	351						aggresome|cytoplasm|nucleolus	ATP binding|nucleoside-triphosphatase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(13)|ovary(1)|prostate(1)|skin(4)|soft_tissue(1)|urinary_tract(1)	42				GBM - Glioblastoma multiforme(131;0.00501)		ACAGCTTGCTCAAATAGTTCT	0.443000													22	40					1.64293e-13	2.54222e-13	1	1	0
MYRIP	25924	broad.mit.edu	37	3	40251560	40251560	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:40251560G>A	ENST00000302541.6	+	11	2223	c.1881G>A	c.(1879-1881)caG>caA	p.Q627Q	MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000444716.1_Silent_p.Q627Q|MYRIP_ENST00000396217.3_Silent_p.Q538Q|MYRIP_ENST00000425621.1_Silent_p.Q627Q|MYRIP_ENST00000539167.1_Silent_p.Q440Q	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	627	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		ACAACAGCCAGAGTGTCCAGG	0.507000													10	38					0	0	1	0	0
GTF2IRD2P1	401375	broad.mit.edu	37	7	72658179	72658179	+	RNA	SNP	T	T	C	rs147293416	by1000genomes	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:72658179T>C	ENST00000425256.1	-	0	1732					NR_002164.1																						cagagtgatttcggatgaatt	0.507000													6	94					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159490614	159490614	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:159490614C>T	ENST00000389757.3	+	9	1500	c.1375C>T	c.(1375-1377)Caa>Taa	p.Q459*	PKP4_ENST00000389759.3_Nonsense_Mutation_p.Q459*	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	459					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						GACATCCAGCCAACGAAGTAC	0.388000										HNSCC(62;0.18)			18	124					0	0	1	0	0
HLX	3142	broad.mit.edu	37	1	221057701	221057701	+	Silent	SNP	T	T	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:221057701T>G	ENST00000366903.6	+	4	2623	c.1122T>G	c.(1120-1122)gcT>gcG	p.A374A	HLX_ENST00000549319.1_Silent_p.A160A	NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	374	Ser-rich.				cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		AAGGCGAGGCTGAGAGCGAGA	0.632000													8	53					0	0	1	0	0
AMER3	205147	broad.mit.edu	37	2	131521418	131521418	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:131521418G>T	ENST00000423981.1	+	2	1883	c.1773G>T	c.(1771-1773)ggG>ggT	p.G591G	AMER3_ENST00000321420.4_Silent_p.G591G	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		CCACACAAGGGACTGGCACAC	0.622000													14	58					4.3838e-07	5.4922e-07	1	1	0
SLITRK4	139065	broad.mit.edu	37	X	142716846	142716846	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:142716846C>A	ENST00000381779.4	-	2	2304	c.2079G>T	c.(2077-2079)caG>caT	p.Q693H	SLITRK4_ENST00000338017.4_Missense_Mutation_p.Q693H|SLITRK4_ENST00000356928.1_Missense_Mutation_p.Q693H	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	693						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTGCTCATCTGTTCTATAG	0.443000													28	202					7.01153e-11	9.75422e-11	1	1	0
ONECUT1	3175	broad.mit.edu	37	15	53081103	53081103	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:53081103G>T	ENST00000305901.5	-	1	1106	c.979C>A	c.(979-981)Ctc>Atc	p.L327I	ONECUT1_ENST00000561401.2_Intron	NM_004498.2	NP_004489.1	Q9UBC0	HNF6_HUMAN	one cut homeobox 1	327					endocrine pancreas development	nucleus	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	17				all cancers(107;0.0708)		AGGTCCGAGAGGGTCCCCTGG	0.632000													13	44					0.00244969	0.00266745	1	1	0
COL6A5	256076	broad.mit.edu	37	3	130095281	130095281	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:130095281G>A	ENST00000265379.6	+	3	763	c.269G>A	c.(268-270)aGa>aAa	p.R90K	COL6A5_ENST00000432398.2_Missense_Mutation_p.R90K			A8TX70	CO6A5_HUMAN	collagen, type VI, alpha 5	90	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				endometrium(6)|kidney(4)|large_intestine(8)|lung(19)|pancreas(2)|prostate(3)|stomach(1)|urinary_tract(1)	44						TTCAAAGGCAGAAGCCCCATG	0.512000													4	28					0	0	1	0	0
LILRP2	79166	broad.mit.edu	37	19	55220425	55220425	+	RNA	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:55220425C>G	ENST00000413439.1	+	0	563																											GAGCCAGGCTCTGTGATTACC	0.612000													8	11					0	0	1	0	0
SCP2D1	140856	broad.mit.edu	37	20	18794596	18794596	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:18794596C>G	ENST00000377428.2	+	1	227	c.137C>G	c.(136-138)cCa>cGa	p.P46R	C20orf78_ENST00000278779.4_Intron	NM_178483.2	NP_848578.1			SCP2 sterol-binding domain containing 1																		GAGAGCTTCCCAGTGTTTCAG	0.507000													7	71					0	0	1	0	0
FMR1	2332	broad.mit.edu	37	X	147024827	147024827	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:147024827C>A	ENST00000218200.8	+	13	1618	c.1389C>A	c.(1387-1389)cgC>cgA	p.R463R	FMR1_ENST00000440235.2_Silent_p.R131R|FMR1_ENST00000370471.3_Intron|FMR1_ENST00000370470.1_Silent_p.R484R|FMR1_ENST00000370475.4_Silent_p.R484R|FMR1_ENST00000370477.1_Silent_p.R463R|FMR1_ENST00000492846.1_3'UTR|FMR1_ENST00000439526.2_Silent_p.R461R	NM_001185076.1|NM_001185082.1	NP_001172005.1|NP_001172011.1	Q06787	FMR1_HUMAN	fragile X mental retardation 1	484	Interaction with RANBP9.				mRNA transport|negative regulation of translational initiation	cytoplasm|mRNA cap binding complex|nucleolus|nucleoplasm|soluble fraction	mRNA binding|protein binding	p.R484R(1)		NS(1)|breast(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	35	Acute lymphoblastic leukemia(192;6.56e-05)					ACGGCAGACGCGGTCCTGGAT	0.418000									Fragile X syndrome				28	137					4.22769e-11	5.91877e-11	1	1	0
PAGE3	139793	broad.mit.edu	37	X	55287035	55287035	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:55287035C>T	ENST00000374951.1	-	4	559	c.251G>A	c.(250-252)cGt>cAt	p.R84H	PAGE3_ENST00000519203.1_Missense_Mutation_p.R84H					P antigen family, member 3 (prostate associated)											endometrium(1)|kidney(1)|lung(1)	3						ACCATCTCCACGTTCACCCCC	0.393000													13	60					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204067	9204067	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:9204067C>T	ENST00000429566.3	+	1	213	c.147C>T	c.(145-147)atC>atT	p.I49I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						TCCTGGCCATCAGCATAGACT	0.542000													11	106					0	0	1	0	0
RRP7BP	91695	broad.mit.edu	37	22	42971967	42971967	+	RNA	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr22:42971967C>A	ENST00000357802.2	-	0	753																											TGCTGCCAGGCGTAGTTGAGC	0.672000													6	14					0.0215528	0.0225231	1	1	0
LILRB1	10859	broad.mit.edu	37	19	55142976	55142976	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:55142976G>T	ENST00000396331.1	+	5	453	c.96G>T	c.(94-96)tgG>tgT	p.W32C	LILRB1_ENST00000324602.7_Missense_Mutation_p.W32C|LILRB1_ENST00000396317.1_Missense_Mutation_p.W32C|LILRB1_ENST00000396315.1_Missense_Mutation_p.W32C|LILRB1_ENST00000396321.2_Missense_Mutation_p.W32C|LILRB1_ENST00000396327.3_Missense_Mutation_p.W32C|LILRB1_ENST00000434867.2_Missense_Mutation_p.W32C|LILRB1_ENST00000427581.2_Missense_Mutation_p.W68C|LILRB1_ENST00000396332.4_Missense_Mutation_p.W32C|LILRB1_ENST00000418536.2_Missense_Mutation_p.W32C|LILRB1_ENST00000448689.1_Missense_Mutation_p.W32C	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	32	Ig-like C2-type 1.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCACCCTCTGGGCTGAACCAG	0.572000										HNSCC(37;0.09)			53	102					9.72345e-25	1.75739e-24	1	1	0
CYP51A1	1595	broad.mit.edu	37	7	91763632	91763632	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:91763632C>A	ENST00000003100.8	-	1	212	c.47G>T	c.(46-48)gGt>gTt	p.G16V	CYP51A1_ENST00000450723.1_Intron|LRRD1_ENST00000422722.1_Intron	NM_000786.3	NP_000777.1	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A, polypeptide 1	10					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|skin(1)	10	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	CACCGACCCACCCGCCTGCAG	0.662000											OREG0018160	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	8					0.115264	0.116586	1	1	0
RBM26	64062	broad.mit.edu	37	13	79933723	79933723	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr13:79933723T>C	ENST00000438737.2	-	10	1956	c.1516A>G	c.(1516-1518)Act>Gct	p.T506A	RBM26_ENST00000267229.7_Missense_Mutation_p.T506A|RBM26_ENST00000438724.1_Missense_Mutation_p.T506A			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	506					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TCAAACCAAGTCTTCTTTGTA	0.378000													19	77					0	0	1	0	0
FAM83C	128876	broad.mit.edu	37	20	33874997	33874997	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:33874997G>T	ENST00000374408.3	-	4	1681	c.1585C>A	c.(1585-1587)Ccc>Acc	p.P529T		NM_178468.5	NP_848563.1	Q9BQN1	FA83C_HUMAN	family with sequence similarity 83, member C	529										central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(18;0.00252)			CCTGAGTTGGGGGTAACCCCA	0.652000													14	54					8.60227e-14	1.3405e-13	1	1	0
NOBOX	135935	broad.mit.edu	37	7	144096266	144096266	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:144096266G>T	ENST00000467773.1	-	8	1245	c.1246C>A	c.(1246-1248)Ccc>Acc	p.P416T	NOBOX_ENST00000483238.1_Missense_Mutation_p.P384T|NOBOX_ENST00000223140.5_Missense_Mutation_p.P299T	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	416	Pro-rich.				cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					AGCAGCATGGGGGGCTCTAGG	0.597000													10	20					2.17888e-05	2.5761e-05	1	1	0
SLC8A1	6546	broad.mit.edu	37	2	40342419	40342419	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:40342419C>A	ENST00000406785.1	-	8	2977	c.2788G>T	c.(2788-2790)Gcc>Tcc	p.A930S	SLC8A1-AS1_ENST00000601679.1_RNA|SLC8A1-AS1_ENST00000599956.1_RNA|SLC8A1-AS1_ENST00000599740.1_RNA|SLC8A1-AS1_ENST00000599268.1_RNA|SLC8A1-AS1_ENST00000598247.1_RNA|SLC8A1-AS1_ENST00000597385.1_RNA|SLC8A1-AS1_ENST00000597170.1_RNA|SLC8A1-AS1_ENST00000596532.1_RNA|SLC8A1-AS1_ENST00000593848.1_RNA|SLC8A1-AS1_ENST00000593878.1_RNA|SLC8A1-AS1_ENST00000444629.1_RNA|SLC8A1_ENST00000542756.1_Missense_Mutation_p.A961S|SLC8A1_ENST00000542024.1_Missense_Mutation_p.A930S|SLC8A1_ENST00000405269.1_Missense_Mutation_p.A930S|SLC8A1-AS1_ENST00000435515.1_RNA|SLC8A1_ENST00000403092.1_Missense_Mutation_p.A966S|SLC8A1_ENST00000408028.2_Missense_Mutation_p.A958S|SLC8A1_ENST00000406391.2_Missense_Mutation_p.A930S|SLC8A1_ENST00000405901.3_Missense_Mutation_p.A961S|SLC8A1_ENST00000402441.1_Missense_Mutation_p.A930S|SLC8A1_ENST00000332839.4_Missense_Mutation_p.A966S			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	966					cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TGGCAGTAGGCCTCCAGGGAG	0.418000													17	63					1.45105e-14	2.31016e-14	1	1	0
LAMP5	24141	broad.mit.edu	37	20	9496233	9496233	+	Silent	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:9496233T>C	ENST00000246070.2	+	2	690	c.198T>C	c.(196-198)ttT>ttC	p.F66F	LAMP5_ENST00000427562.2_Silent_p.F66F	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	66						integral to membrane											CAGCCAAATTTATTGTACCTT	0.498000													15	127					0	0	1	0	0
ZNF581	51545	broad.mit.edu	37	19	56156064	56156064	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:56156064C>T	ENST00000587252.1	+	2	400	c.127C>T	c.(127-129)Cag>Tag	p.Q43*	ZNF581_ENST00000270451.5_Nonsense_Mutation_p.Q43*|ZNF581_ENST00000588537.1_Nonsense_Mutation_p.Q43*			Q9P0T4	ZN581_HUMAN	zinc finger protein 581	43					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)	3		Ovarian(87;0.133)	BRCA - Breast invasive adenocarcinoma(297;0.18)	GBM - Glioblastoma multiforme(193;0.105)		CGGATCTCCCCAGGCTTCATC	0.607000													3	20					0	0	1	0	0
CLCA2	9635	broad.mit.edu	37	1	86896581	86896581	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:86896581G>T	ENST00000370565.4	+	4	674	c.512G>T	c.(511-513)tGg>tTg	p.W171L		NM_006536.5	NP_006527.1	Q9UQC9	CLCA2_HUMAN	chloride channel accessory 2	171					cell adhesion	basal plasma membrane|cell junction|extracellular region|integral to plasma membrane	chloride channel activity			NS(2)|breast(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(18)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	42		Lung NSC(277;0.238)		all cancers(265;0.0233)|Epithelial(280;0.0452)		CACCTCCGTTGGGGTGTGTTC	0.393000													39	163					2.24893e-16	3.71453e-16	1	1	0
CPQ	10404	broad.mit.edu	37	8	97797544	97797544	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:97797544G>T	ENST00000220763.5	+	2	629	c.419G>T	c.(418-420)gGg>gTg	p.G140V		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	140					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										AGCAGCATTGGGACTCCTCCA	0.418000													3	33					0.115264	0.116586	1	1	0
L1CAM	3897	broad.mit.edu	37	X	153133494	153133494	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:153133494T>A	ENST00000370060.1	-	15	1976	c.1787A>T	c.(1786-1788)gAa>gTa	p.E596V	L1CAM_ENST00000370055.1_Missense_Mutation_p.E591V|L1CAM_ENST00000361981.3_Missense_Mutation_p.E591V|L1CAM_ENST00000543994.1_Missense_Mutation_p.E598V|L1CAM_ENST00000538883.1_Missense_Mutation_p.E598V|L1CAM_ENST00000361699.4_Missense_Mutation_p.E596V|L1CAM_ENST00000370057.3_Missense_Mutation_p.E596V	NM_001278116.1	NP_001265045.1	P32004	L1CAM_HUMAN	L1 cell adhesion molecule	596	Ig-like C2-type 6.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				NS(1)|breast(4)|central_nervous_system(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|liver(1)|lung(31)|ovary(13)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	81	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CACATCCAGTTCGGTACTGGC	0.617000													27	96					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31769688	31769688	+	Silent	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:31769688T>A	ENST00000240587.4	-	2	1338	c.1011A>T	c.(1009-1011)acA>acT	p.T337T		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	337					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					GGGTTCCACCTGTGGAATCTG	0.557000													75	131					0	0	1	0	0
PRSS36	146547	broad.mit.edu	37	16	31155049	31155049	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:31155049G>A	ENST00000268281.4	-	7	888	c.830C>T	c.(829-831)aCt>aTt	p.T277I	PRSS36_ENST00000418068.2_Missense_Mutation_p.T277I|PRSS36_ENST00000569305.1_Missense_Mutation_p.T277I	NM_001258290.1|NM_173502.4	NP_001245219.1|NP_775773.2	Q5K4E3	POLS2_HUMAN	protease, serine, 36	277	Peptidase S1 1.				proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			kidney(2)|large_intestine(4)|lung(8)|ovary(3)	17						AGCCACAGCAGTGAAAACTCC	0.622000													32	106					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176301048	176301048	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:176301048C>A	ENST00000329542.4	+	7	1240	c.966C>A	c.(964-966)gtC>gtA	p.V322V	UNC5A_ENST00000261961.3_Silent_p.V282V	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	322					apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TGCTGCTTGTCCTCATCCTCG	0.617000													6	44					8.12818e-05	9.31047e-05	1	1	0
LOC93432	93432	broad.mit.edu	37	7	141833943	141833943	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:141833943C>A	ENST00000477922.3	+	7	792	c.738C>A	c.(736-738)acC>acA	p.T246T	RP11-1220K2.2_ENST00000550469.2_Silent_p.T246T																endometrium(1)|lung(5)	6						GGGACGCTACCCCCACCGAGG	0.542000													3	13					0.115264	0.116586	1	1	0
ATP5E	514	broad.mit.edu	37	20	57605429	57605429	+	Nonsense_Mutation	SNP	C	C	A	rs7509466		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:57605429C>A	ENST00000243997.3	-	2	218	c.88G>T	c.(88-90)Gaa>Taa	p.E30*	ATP5E_ENST00000395663.1_Nonsense_Mutation_p.E30*|ATP5E_ENST00000395659.1_Nonsense_Mutation_p.E30*	NM_006886.3	NP_008817.1	P56381	ATP5E_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit	30					respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1	all_lung(29;0.00711)		Colorectal(105;0.109)			GCTTTGAATTCTGTCTTCAGT	0.368000													9	69					2.17888e-05	2.5761e-05	1	1	0
HTR1E	3354	broad.mit.edu	37	6	87725404	87725404	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:87725404C>A	ENST00000305344.4	+	2	1055	c.352C>A	c.(352-354)Ctg>Atg	p.L118M	HTR1E_ENST00000369584.1_Missense_Mutation_p.L118M	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	118					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	TGTCATTGCCCTGGACAGGTA	0.567000													38	92					2.1956e-27	4.06831e-27	1	1	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973568	29973568	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:29973568T>A	ENST00000378993.1	+	11	2395	c.1722T>A	c.(1720-1722)gaT>gaA	p.D574E	IL1RAPL1_ENST00000302196.4_Missense_Mutation_p.D574E	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	574	Interaction with NCS1.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						AGGCTTTAGATGTCAGTGAGC	0.502000													17	48					0	0	1	0	0
CAPN15	6650	broad.mit.edu	37	16	601521	601521	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:601521G>T	ENST00000219611.2	+	9	2565	c.2202G>T	c.(2200-2202)cgG>cgT	p.R734R	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		GGCTTCTGCGGCTCCGAAACC	0.692000													52	76					3.77171e-38	7.26343e-38	1	1	0
PHB2	11331	broad.mit.edu	37	12	7079659	7079659	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:7079659G>A	ENST00000535923.1	-	1	329	c.48C>T	c.(46-48)ccC>ccT	p.P16P	PHB2_ENST00000440277.1_Silent_p.P16P|PHB2_ENST00000399433.2_Silent_p.P16P|PHB2_ENST00000542912.1_Silent_p.P16P|PHB2_ENST00000544134.1_5'UTR|PHB2_ENST00000546111.1_Silent_p.P16P	NM_001144831.1	NP_001138303.1	Q99623	PHB2_HUMAN	prohibitin 2	16					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						CCATGCCCCGGGGCCCGGCGG	0.706000													5	19					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28362196	28362196	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:28362196G>A	ENST00000261609.7	-	87	13485	c.13377C>T	c.(13375-13377)ctC>ctT	p.L4459L		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4459	HECT.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GAGGAAGGAGGAGGCTGTCGG	0.607000													6	36					0	0	1	0	0
NPTX1	4884	broad.mit.edu	37	17	78449351	78449351	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:78449351G>A	ENST00000306773.4	-	2	769	c.612C>T	c.(610-612)gcC>gcT	p.A204A	NPTX1_ENST00000575212.1_5'UTR	NM_002522.3	NP_002513.2	Q15818	NPTX1_HUMAN	neuronal pentraxin I	204					central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)	11	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			GGGAGGTCAGGGCGGTCTCGA	0.677000													3	29					0	0	1	0	0
LPPR4	9890	broad.mit.edu	37	1	99753637	99753637	+	Silent	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:99753637T>A	ENST00000370185.3	+	2	836	c.339T>A	c.(337-339)atT>atA	p.I113I	LPPR4_ENST00000457765.1_Silent_p.I113I	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		113							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TGCCGTACATTGAACCAACCC	0.458000													30	86					0	0	1	0	0
OR13A1	79290	broad.mit.edu	37	10	45799706	45799706	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:45799706C>A	ENST00000553795.1	-	4	473	c.165G>T	c.(163-165)ggG>ggT	p.G55G	OR13A1_ENST00000374401.2_Silent_p.G55G|OR13A1_ENST00000536058.1_Silent_p.G55G	NM_001004297.2	NP_001004297.2	Q8NGR1	O13A1_HUMAN	olfactory receptor, family 13, subfamily A, member 1	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|skin(2)|urinary_tract(1)	19						CTGTGAGGGCCCCAGAGTAGA	0.507000													5	45					0.014758	0.01557	1	1	0
PSG8	440533	broad.mit.edu	37	19	43258737	43258737	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:43258737C>A	ENST00000404209.4	-	5	1087	c.991G>T	c.(991-993)Ggt>Tgt	p.G331C	PSG8_ENST00000406636.3_Missense_Mutation_p.G209C|PSG8_ENST00000401467.2_Missense_Mutation_p.G238C|PSG8_ENST00000306511.4_Missense_Mutation_p.G331C|PSG8_ENST00000600709.1_5'UTR	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	331						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				AGGTCTGGACCATCTGGAGCA	0.507000													56	89					7.75977e-34	1.47503e-33	1	1	0
NAV3	89795	broad.mit.edu	37	12	78400686	78400686	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:78400686C>A	ENST00000397909.2	+	8	1541	c.1368C>A	c.(1366-1368)ctC>ctA	p.L456L	NAV3_ENST00000228327.6_Silent_p.L456L|NAV3_ENST00000266692.7_Silent_p.L456L|NAV3_ENST00000536525.2_Silent_p.L456L			Q8IVL0	NAV3_HUMAN	neuron navigator 3	456						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						GCAAAAATCTCAGCAATAAAA	0.403000										HNSCC(70;0.22)			29	60					8.58068e-18	1.44431e-17	1	1	0
ZNF845	91664	broad.mit.edu	37	19	53855009	53855009	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:53855009G>T	ENST00000458035.1	+	4	1198	c.1081G>T	c.(1081-1083)Gac>Tac	p.D361Y	ZNF845_ENST00000595091.1_Missense_Mutation_p.D361Y	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	361					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						TGAAGAATGTGACAAAGCTTT	0.388000													16	70					2.32078e-09	3.09204e-09	1	1	0
EDA	1896	broad.mit.edu	37	X	69176904	69176904	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:69176904G>C	ENST00000374552.4	+	2	666	c.424G>C	c.(424-426)Gat>Cat	p.D142H	EDA_ENST00000502251.1_3'UTR|EDA_ENST00000374553.2_Missense_Mutation_p.D142H|EDA_ENST00000524573.1_Missense_Mutation_p.D142H	NM_001399.4	NP_001390.1	Q92838	EDA_HUMAN	ectodysplasin A	142					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|urinary_tract(1)	14						CTTCTTCCCTGATGAAAAGCC	0.403000													15	51					0	0	1	0	0
DBH	1621	broad.mit.edu	37	9	136508552	136508552	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr9:136508552C>T	ENST00000393056.2	+	4	774	c.762C>T	c.(760-762)acC>acT	p.T254T		NM_000787.3	NP_000778.3	P09172	DOPO_HUMAN	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	254					hormone biosynthetic process	chromaffin granule lumen|chromaffin granule membrane|extracellular region|integral to membrane|membrane fraction|soluble fraction|transport vesicle membrane	dopamine beta-monooxygenase activity|L-ascorbic acid binding			central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(9)|liver(1)|lung(6)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	36				OV - Ovarian serous cystadenocarcinoma(145;2.33e-07)|Epithelial(140;1.5e-06)|all cancers(34;1.66e-05)	Dopamine(DB00988)|Vitamin C(DB00126)	CCATCGTCACCAAGGGCAATG	0.657000													19	58					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27481653	27481653	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:27481653C>A	ENST00000356183.4	-	31	4605	c.4590G>T	c.(4588-4590)atG>atT	p.M1530I	GTF3C1_ENST00000561623.1_Missense_Mutation_p.M1530I	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1530						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CGGCAGCCCGCATTCTGTCCA	0.512000													111	197					3.68091e-61	7.21459e-61	1	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3680084	3680084	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:3680084C>A	ENST00000344754.4	-	7	1550	c.1551G>T	c.(1549-1551)ccG>ccT	p.P517P	SIGLEC1_ENST00000202578.4_Silent_p.P517P	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	517	Ig-like C2-type 5.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CCTCGGCTGCCGGGCTGATGA	0.632000													6	11					3.09899e-07	3.92716e-07	1	1	0
SMR3B	10879	broad.mit.edu	37	4	71255432	71255432	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:71255432C>A	ENST00000304915.3	+	3	256	c.107C>A	c.(106-108)gCt>gAt	p.A36D	SMR3B_ENST00000504825.1_Missense_Mutation_p.A36D	NM_006685.3	NP_006676.1			submaxillary gland androgen regulated protein 3B											large_intestine(2)|lung(3)|skin(2)	7		all_hematologic(202;0.196)				GGACCGCTGGCTCCTCCTCAA	0.522000													30	84					4.40665e-25	8.03029e-25	1	1	0
SLC22A6	9356	broad.mit.edu	37	11	62751103	62751103	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:62751103G>T	ENST00000377871.3	-	3	800	c.534C>A	c.(532-534)tgC>tgA	p.C178*	SLC22A6_ENST00000421062.2_Nonsense_Mutation_p.C178*|SLC22A6_ENST00000458333.2_Nonsense_Mutation_p.C178*|SLC22A6_ENST00000360421.4_Nonsense_Mutation_p.C178*|SLC22A6_ENST00000537349.1_5'UTR	NM_004790.4|NM_153278.2	NP_004781.2|NP_695010.1	Q4U2R8	S22A6_HUMAN	solute carrier family 22 (organic anion transporter), member 6	178					alpha-ketoglutarate transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(18)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CGAAGGCTGCGCAGGTCCCTG	0.612000													6	15					0.0381472	0.0393059	1	1	0
CKB	1152	broad.mit.edu	37	14	103987647	103987647	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:103987647C>T	ENST00000348956.2	-	5	963	c.606G>A	c.(604-606)ctG>ctA	p.L202L		NM_001823.4	NP_001814.2	P12277	KCRB_HUMAN	creatine kinase, brain	202	Phosphagen kinase C-terminal.				creatine metabolic process	cytosol	ATP binding|creatine kinase activity			lung(2)|prostate(1)	3		Melanoma(154;0.155)	Epithelial(46;0.14)		Creatine(DB00148)	CCGAGGCCAGCAGCAGGGGCG	0.701000													5	10					0	0	1	0	0
OPHN1	4983	broad.mit.edu	37	X	67421506	67421506	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:67421506T>C	ENST00000355520.5	-	11	1621	c.980A>G	c.(979-981)gAg>gGg	p.E327G	OPHN1_ENST00000540071.1_Missense_Mutation_p.E327G	NM_002547.2	NP_002538.1	O60890	OPHN1_HUMAN	oligophrenin 1	327	PH.				axon guidance|endocytosis|filopodium assembly|small GTPase mediated signal transduction|substrate-dependent cell migration, cell extension	axon|cell junction|cytosol|dendritic spine|synapse	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|skin(2)	31						GTCGATAGACTCCGTCTTCCT	0.433000													18	149					0	0	1	0	0
FNIP1	96459	broad.mit.edu	37	5	131055009	131055009	+	Splice_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:131055009C>A	ENST00000307968.7	-	4	455		c.e4+1		FNIP1_ENST00000307954.8_Splice_Site|FNIP1_ENST00000514667.1_Intron|FNIP1_ENST00000511848.1_Splice_Site|FNIP1_ENST00000510461.1_Splice_Site	NM_001008738.2	NP_001008738.2			folliculin interacting protein 1											NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(11)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		AAACCTCTCACCGAATCTGAT	0.363000													11	32					0.000978159	0.00108384	1	1	0
KEAP1	9817	broad.mit.edu	37	19	10602875	10602875	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:10602875C>G	ENST00000171111.5	-	3	1250	c.703G>C	c.(703-705)Gac>Cac	p.D235H	KEAP1_ENST00000588024.1_5'UTR|KEAP1_ENST00000393623.2_Missense_Mutation_p.D235H	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	235	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TTCAGGTCGTCCCGGCTGATG	0.617000													19	41					0	0	1	0	0
TRIOBP	11078	broad.mit.edu	37	22	38165044	38165044	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr22:38165044G>A	ENST00000406386.3	+	20	6840	c.6585G>A	c.(6583-6585)gtG>gtA	p.V2195V	TRIOBP_ENST00000403663.2_Silent_p.V482V|RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	2195					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					GGTCAGATGTGGAGGCACTGA	0.592000													19	65					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57766805	57766805	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:57766805G>C	ENST00000371030.2	+	1	731	c.731G>C	c.(730-732)aGa>aCa	p.R244T		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	244						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCCTCGGAGAGACCCCTTTCT	0.672000													14	57					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50766620	50766620	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:50766620G>T	ENST00000440075.2	+	22	2684	c.2637G>T	c.(2635-2637)cgG>cgT	p.R879R	MYH14_ENST00000598205.1_Silent_p.R846R|MYH14_ENST00000596571.1_Silent_p.R838R|MYH14_ENST00000425460.1_Silent_p.R846R|MYH14_ENST00000376970.2_Silent_p.R871R|MYH14_ENST00000262269.8_Silent_p.R879R|MYH14_ENST00000601313.1_Silent_p.R879R			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	838					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		TGATGCAGCGGAACTGCGCGG	0.657000													3	12					0.115264	0.116586	1	1	0
GAL3ST4	79690	broad.mit.edu	37	7	99764167	99764167	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:99764167G>T	ENST00000360039.4	-	3	779	c.387C>A	c.(385-387)ccC>ccA	p.P129P	GAL3ST4_ENST00000482469.1_5'UTR|GAL3ST4_ENST00000413800.1_Silent_p.P129P|GAL3ST4_ENST00000423751.1_Intron|GAL3ST4_ENST00000411994.1_Intron|GAL3ST4_ENST00000426974.2_Intron	NM_024637.4	NP_078913.3	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	129					cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(5)|prostate(1)|upper_aerodigestive_tract(1)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGATGTGGAAGGGGAGCTGGG	0.592000													16	153					1.02788e-11	1.47654e-11	1	1	0
ABHD1	84696	broad.mit.edu	37	2	27353609	27353609	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:27353609C>A	ENST00000316470.4	+	9	1329	c.1215C>A	c.(1213-1215)agC>agA	p.S405R		NM_032604.3	NP_115993.3	Q96SE0	ABHD1_HUMAN	abhydrolase domain containing 1	405						integral to membrane	carboxylesterase activity			endometrium(1)|kidney(1)|lung(3)	5	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ACAGAAACAGCTGACAAGAGT	0.488000													15	69					6.31663e-08	8.14512e-08	1	1	0
GSG1	83445	broad.mit.edu	37	12	13237959	13237959	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:13237959G>T	ENST00000337630.6	-	6	924	c.857C>A	c.(856-858)cCc>cAc	p.P286H	GSG1_ENST00000432710.2_Missense_Mutation_p.P299H|GSG1_ENST00000457134.2_Missense_Mutation_p.P235H|GSG1_ENST00000324458.8_Missense_Mutation_p.P322H|GSG1_ENST00000351606.6_3'UTR|GSG1_ENST00000537302.1_Missense_Mutation_p.P258H|GSG1_ENST00000396302.3_3'UTR|GSG1_ENST00000396310.2_Missense_Mutation_p.P255H	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	309						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		AGAGTGGATGGGCTGATTATG	0.552000													7	12					0.0293803	0.0304864	1	1	0
NRXN2	9379	broad.mit.edu	37	11	64465257	64465257	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:64465257G>A	ENST00000265459.6	-	3	1199	c.738C>T	c.(736-738)caC>caT	p.H246H	NRXN2_ENST00000377551.1_Silent_p.H246H|NRXN2_ENST00000409571.1_Silent_p.H246H|NRXN2_ENST00000377559.3_Silent_p.H246H	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	246					cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CTTCCATGGGGTGCTCCTCTG	0.582000													7	38					0	0	1	0	0
MAPKBP1	23005	broad.mit.edu	37	15	42114454	42114454	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:42114454T>A	ENST00000457542.2	+	26	3349	c.3063T>A	c.(3061-3063)gaT>gaA	p.D1021E	MAPKBP1_ENST00000260357.7_Missense_Mutation_p.D860E|MAPKBP1_ENST00000456763.2_Missense_Mutation_p.D1027E|MAPKBP1_ENST00000514566.1_Missense_Mutation_p.D1021E|MAPKBP1_ENST00000221214.6_Missense_Mutation_p.D904E	NM_014994.2	NP_055809.2	O60336	MABP1_HUMAN	mitogen-activated protein kinase binding protein 1	1027										breast(6)|central_nervous_system(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_cancers(109;7.71e-14)|all_epithelial(112;5.15e-12)|Lung NSC(122;3.74e-08)|all_lung(180;1.81e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.95e-17)|GBM - Glioblastoma multiforme(94;5.71e-07)|Lung(196;0.0436)|BRCA - Breast invasive adenocarcinoma(123;0.203)|LUSC - Lung squamous cell carcinoma(244;0.225)		TCAGTGTGGATGGCATCTCCT	0.627000													9	31					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57367419	57367419	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:57367419G>T	ENST00000403558.1	+	2	587	c.221G>T	c.(220-222)aGa>aTa	p.R74I	SERPING1_ENST00000340687.6_Missense_Mutation_p.R40I|SERPING1_ENST00000278407.4_Missense_Mutation_p.R40I|SERPING1_ENST00000378323.4_Missense_Mutation_p.R45I|SERPING1_ENST00000378324.2_5'UTR	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	40					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						TTGCAAGACAGAGGCGAAGGG	0.473000													31	82					1.62565e-12	2.43021e-12	1	1	0
STARD10	10809	broad.mit.edu	37	11	72469605	72469605	+	Nonsense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:72469605G>C	ENST00000334805.6	-	4	1348	c.429C>G	c.(427-429)taC>taG	p.Y143*	STARD10_ENST00000538536.1_Nonsense_Mutation_p.Y97*|STARD10_ENST00000545082.1_Nonsense_Mutation_p.Y114*|STARD10_ENST00000543304.1_Nonsense_Mutation_p.Y143*|STARD10_ENST00000538437.1_5'UTR|ARAP1_ENST00000359373.5_Intron	NM_006645.2	NP_006636.2	Q9Y365	PCTL_HUMAN	StAR-related lipid transfer (START) domain containing 10	143	START.									endometrium(4)|large_intestine(1)|lung(2)|prostate(1)	8			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			TCATAATGATGTAATCAGCGC	0.607000													9	47					0	0	1	0	0
HOXA5	3202	broad.mit.edu	37	7	27181620	27181620	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:27181620A>T	ENST00000222726.3	-	2	707	c.647T>A	c.(646-648)tTc>tAc	p.F216Y	HOXA-AS3_ENST00000518848.1_RNA|HOXA-AS3_ENST00000521197.1_RNA|HOXA3_ENST00000467897.2_Intron|HOXA5_ENST00000520854.1_5'UTR	NM_019102.3	NP_061975.2	P20719	HXA5_HUMAN	homeobox A5	216					negative regulation of angiogenesis|negative regulation of erythrocyte differentiation|positive regulation of apoptosis|positive regulation of myeloid cell differentiation|positive regulation of receptor biosynthetic process|positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(2)|lung(12)|skin(1)	16						GTAACGGTTGAAGTGGAACTC	0.522000											OREG0017911	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	123					0	0	1	0	0
TCEAL2	140597	broad.mit.edu	37	X	101381936	101381936	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:101381936G>T	ENST00000372780.1	+	3	353	c.134G>T	c.(133-135)gGa>gTa	p.G45V	TCEAL2_ENST00000329035.2_Missense_Mutation_p.G45V	NM_080390.3	NP_525129.1	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	45					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						GAAAACGAGGGAAACACAGAA	0.458000													9	52					1.12685e-05	1.35406e-05	1	1	0
TBR1	10716	broad.mit.edu	37	2	162279889	162279889	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:162279889C>T	ENST00000389554.3	+	6	1517	c.1200C>T	c.(1198-1200)acC>acT	p.T400T	TBR1_ENST00000489530.1_3'UTR|AC009487.4_ENST00000437683.1_RNA|TBR1_ENST00000410035.1_Silent_p.T113T	NM_006593.2	NP_006584.1	Q16650	TBR1_HUMAN	T-box, brain, 1	400						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(3)	30						GGATCTACACCGGCTGTGACA	0.701000													10	55					0	0	1	0	0
ST6GALNAC2	10610	broad.mit.edu	37	17	74569430	74569430	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:74569430A>G	ENST00000225276.5	-	4	696	c.377T>C	c.(376-378)cTg>cCg	p.L126P	ST6GALNAC2_ENST00000586520.1_5'UTR	NM_006456.2	NP_006447.2	Q9UJ37	SIA7B_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2	126					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	11						CAGAAGGCTCAGGGTGGAGGC	0.647000													2	14					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79057007	79057007	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:79057007G>T	ENST00000388820.4	-	20	4519	c.4309C>A	c.(4309-4311)Cgc>Agc	p.R1437S		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1437	TSP type-1 5.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						GAGCTACAGCGCACCGGCCTC	0.726000													2	9					0.0784	0.080593	1	1	0
GPR173	54328	broad.mit.edu	37	X	53106004	53106004	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:53106004C>A	ENST00000332582.4	+	2	692	c.201C>A	c.(199-201)gcC>gcA	p.A67A		NM_018969.5	NP_061842.1	Q9NS66	GP173_HUMAN	G protein-coupled receptor 173	67						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(1)	16						TGTGCCTGGCCGATGGCATAC	0.607000													11	117					3.07112e-06	3.76212e-06	1	1	0
MIR329-2	574409	broad.mit.edu	37	14	101493495	101493495	+	RNA	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:101493495C>T	ENST00000385029.1	+	0	59					NR_029968.1																						CGAAACACACCTGGTTAACCT	0.468000													16	139					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77808128	77808128	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:77808128C>A	ENST00000269397.4	-	5	1490	c.1313G>T	c.(1312-1314)tGc>tTc	p.C438F		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	438	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			GCCCCCCAGGCAGGTGGGGGT	0.706000													4	4					0.00909568	0.0096423	1	1	0
CCDC91	55297	broad.mit.edu	37	12	28458616	28458616	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:28458616G>T	ENST00000545336.1	+	7	563	c.144G>T	c.(142-144)gaG>gaT	p.E48D	CCDC91_ENST00000540401.1_3'UTR|CCDC91_ENST00000381256.1_Missense_Mutation_p.E48D|CCDC91_ENST00000381259.1_Missense_Mutation_p.E48D|CCDC91_ENST00000539107.1_Missense_Mutation_p.E48D|CCDC91_ENST00000306172.5_Missense_Mutation_p.E18D			Q7Z6B0	CCD91_HUMAN	coiled-coil domain containing 91	48					protein transport	Golgi apparatus|membrane				NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|skin(1)	22	Acute lymphoblastic leukemia(23;0.00718)|all_hematologic(23;0.0113)|Lung SC(9;0.184)					CTTCTCCTGAGATTGTACTGG	0.403000													89	158					6.50375e-52	1.26909e-51	1	1	0
NAP1L2	4674	broad.mit.edu	37	X	72433769	72433769	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:72433769C>A	ENST00000373517.3	-	1	915	c.560G>T	c.(559-561)gGt>gTt	p.G187V	NAP1L2_ENST00000536638.1_Missense_Mutation_p.G45V	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	187	Glu-rich (acidic).				nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					CTCCTCATTACCATACATCTC	0.408000													33	103					1.414e-09	1.90114e-09	1	1	0
MGAM	8972	broad.mit.edu	37	7	141721430	141721430	+	Missense_Mutation	SNP	C	C	G	rs2272326	byFrequency	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:141721430C>G	ENST00000475668.2	+	6	657	c.603C>G	c.(601-603)caC>caG	p.H201Q	MGAM_ENST00000549489.2_Missense_Mutation_p.H201Q			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	201	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCCACGAACACGTGCAGTCCT	0.438000													27	76					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112173973	112173973	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:112173973G>T	ENST00000457016.1	+	16	3062	c.2682G>T	c.(2680-2682)gtG>gtT	p.V894V	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000508376.2_Silent_p.V894V|APC_ENST00000257430.4_Silent_p.V894V			P25054	APC_HUMAN	adenomatous polyposis coli	894	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TGGAAGAAGTGTCAGCCATTC	0.463000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			14	52					1.49906e-05	1.79156e-05	1	1	0
FAT2	2196	broad.mit.edu	37	5	150922516	150922516	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:150922516G>T	ENST00000261800.5	-	9	8184	c.8172C>A	c.(8170-8172)taC>taA	p.Y2724*		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2724	Cadherin 24.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCACTAGACTGTAGATGACTG	0.502000													27	85					7.07758e-08	9.09975e-08	1	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146805379	146805379	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:146805379C>G	ENST00000361727.3	+	5	1207	c.691C>G	c.(691-693)Cag>Gag	p.Q231E		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	231	Laminin G-like 1.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGGAGAAGGACAGCAAGGAGA	0.393000										HNSCC(39;0.1)			22	65					0	0	1	0	0
RCAN2	10231	broad.mit.edu	37	6	46293214	46293214	+	Translation_Start_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:46293214C>A	ENST00000330430.6	-	1	191	c.3G>T	c.(1-3)atG>atT	p.M1I	RCAN2_ENST00000405162.1_Intron|RCAN2_ENST00000306764.7_Intron|RCAN2_ENST00000371374.1_Intron	NM_005822.3	NP_005813.2	Q14206	RCAN2_HUMAN	regulator of calcineurin 2	1					calcium-mediated signaling|central nervous system development		nucleotide binding|protein phosphatase 2B binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	8						TAGGGGCTGGCATTCCCCCTT	0.502000													8	54					0.00307968	0.00332877	1	1	0
ASTN2	23245	broad.mit.edu	37	9	119738990	119738990	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr9:119738990G>C	ENST00000313400.4	-	8	1766	c.1666C>G	c.(1666-1668)Cag>Gag	p.Q556E	ASTN2_ENST00000373996.3_Missense_Mutation_p.Q556E|ASTN2_ENST00000361209.2_Missense_Mutation_p.Q505E|ASTN2_ENST00000361477.3_5'UTR			O75129	ASTN2_HUMAN	astrotactin 2	556						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CCTTCACTCTGTCCCCAGTCA	0.522000													21	61					0	0	1	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49340629	49340629	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:49340629C>T	ENST00000263265.6	-	20	2812	c.2257G>A	c.(2257-2259)Gat>Aat	p.D753N	PLEKHA4_ENST00000355496.5_3'UTR	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	753						cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		ATCCCGGCATCCCACGCGGGC	0.672000													21	34					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25429486	25429486	+	RNA	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:25429486G>T	ENST00000424208.1	+	0	450				SNORD115-8_ENST00000363856.1_RNA	NR_003305.1																						TTGTTCTGAAGAGAGATGATG	0.512000													41	273					4.16155e-14	6.57793e-14	1	1	0
PRKG1	5592	broad.mit.edu	37	10	54031159	54031159	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:54031159A>G	ENST00000373980.4	+	11	1640	c.1223A>G	c.(1222-1224)aAg>aGg	p.K408R	PRKG1-AS1_ENST00000452247.2_RNA|PRKG1_ENST00000401604.2_Missense_Mutation_p.K393R|PRKG1-AS1_ENST00000426785.2_RNA|PRKG1_ENST00000373985.1_Missense_Mutation_p.K381R|PRKG1_ENST00000373975.2_Missense_Mutation_p.K111R	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	393	Protein kinase.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		AAGATTCTCAAGAAACGTCAC	0.433000													8	38					0	0	1	0	0
N6AMT1	29104	broad.mit.edu	37	21	30255348	30255348	+	Silent	SNP	A	A	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr21:30255348A>C	ENST00000303775.5	-	2	205	c.180T>G	c.(178-180)tcT>tcG	p.S60S	N6AMT1_ENST00000351429.3_Silent_p.S60S	NM_013240.4	NP_037372.3	Q9Y5N5	HEMK2_HUMAN	N-6 adenine-specific DNA methyltransferase 1 (putative)	60					positive regulation of cell growth	protein complex	nucleic acid binding|protein binding|protein methyltransferase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(2)	12						CTAGGAATGCAGATACTACAC	0.353000													22	38					0	0	1	0	0
OR2T4	127074	broad.mit.edu	37	1	248525347	248525347	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:248525347C>A	ENST00000366475.1	+	1	465	c.465C>A	c.(463-465)taC>taA	p.Y155*		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGACCGCTACGTGGCCATCT	0.527000													54	256					3.28156e-27	6.05509e-27	1	1	0
OR14I1	401994	broad.mit.edu	37	1	248845369	248845369	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:248845369G>T	ENST00000342623.3	-	1	260	c.237C>A	c.(235-237)tcC>tcA	p.S79S		NM_001004734.1	NP_001004734.1	A6ND48	O14I1_HUMAN	olfactory receptor, family 14, subfamily I, member 1	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(4)|large_intestine(2)|lung(24)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	35						AGTTACGGATGGATTTAGGCA	0.483000													21	42					3.51602e-12	5.22075e-12	1	1	0
ABCC6	368	broad.mit.edu	37	16	16267233	16267233	+	Missense_Mutation	SNP	G	G	C	rs11861980	byFrequency	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:16267233G>C	ENST00000205557.7	-	21	2724	c.2695C>G	c.(2695-2697)Cgt>Ggt	p.R899G		NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	899					response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		GAAGTGGTACGGTCCTTCTCA	0.527000													56	87					0	0	1	0	0
CCDC125	202243	broad.mit.edu	37	5	68578845	68578845	+	Missense_Mutation	SNP	T	T	G	rs146206606	by1000genomes	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:68578845T>G	ENST00000396496.2	-	12	1354	c.1247A>C	c.(1246-1248)gAa>gCa	p.E416A	CCDC125_ENST00000460090.1_5'UTR|CCDC125_ENST00000383374.2_3'UTR|CCDC125_ENST00000511257.1_Missense_Mutation_p.E291A|CCDC125_ENST00000396499.1_Missense_Mutation_p.E416A			Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	416						cytoplasm				breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(7)|urinary_tract(1)	19		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		AGCCAAAGCTTCTTCTTTATC	0.323000													13	30					0	0	1	0	0
SAMHD1	25939	broad.mit.edu	37	20	35545233	35545233	+	Splice_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:35545233C>A	ENST00000262878.4	-	9	1153	c.953_splice	c.e9-1	p.R318_splice	SAMHD1_ENST00000373694.5_Splice_Site_p.R103_splice	NM_015474.3	NP_056289.2	Q9Y3Z3	SAMH1_HUMAN	SAM domain and HD domain 1	318	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	20		Myeloproliferative disorder(115;0.00878)				GATGGCAGTCCCTAGAAGGAT	0.328000													30	131					3.65163e-15	5.89878e-15	1	1	0
ATG5	9474	broad.mit.edu	37	6	106727644	106727644	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:106727644G>A	ENST00000369076.3	-	5	693	c.370C>T	c.(370-372)Cat>Tat	p.H124Y	ATG5_ENST00000360666.4_Intron|ATG5_ENST00000343245.3_Missense_Mutation_p.H124Y|ATG5_ENST00000369070.1_Missense_Mutation_p.H46Y	NM_004849.2	NP_004840.1	Q9H1Y0	ATG5_HUMAN	autophagy related 5	124					apoptosis|autophagic vacuole assembly|negative regulation of type I interferon production|post-translational protein modification	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			endometrium(1)|large_intestine(5)|lung(1)|prostate(1)	8	Breast(9;0.0296)	all_cancers(87;0.000301)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0612)|Lung NSC(302;0.216)	BRCA - Breast invasive adenocarcinoma(8;0.00802)	OV - Ovarian serous cystadenocarcinoma(136;0.128)|Epithelial(106;0.159)|all cancers(137;0.18)		GACATAAAATGAGCTTCAATT	0.328000													16	72					0	0	1	0	0
LOC101927060	101927060	broad.mit.edu	37	17	45127816	45127816	+	RNA	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:45127816C>A	ENST00000575173.1	-	0	418																											GCTAACCCAGCAGCTACAGTC	0.498000													55	201					1.80625e-27	3.361e-27	1	1	0
IGKV2-30	28919	broad.mit.edu	37	2	89545008	89545008	+	RNA	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:89545008C>A	ENST00000468494.1	-	0	71																											TACCTGGGACCCAGAGCATTA	0.557000													9	35					0.000673444	0.000748083	1	1	0
RELN	5649	broad.mit.edu	37	7	103234221	103234221	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:103234221G>T	ENST00000424685.2	-	27	3979	c.3820C>A	c.(3820-3822)Cca>Aca	p.P1274T	RELN_ENST00000343529.5_Missense_Mutation_p.P1274T|RELN_ENST00000428762.1_Missense_Mutation_p.P1274T			P78509	RELN_HUMAN	reelin	1274					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATTGCTGATGGTGTGGCAGCA	0.398000													23	102					9.57634e-11	1.32804e-10	1	1	0
TMPRSS11A	339967	broad.mit.edu	37	4	68777175	68777175	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:68777175C>A	ENST00000508048.1	-	10	1174	c.1139G>T	c.(1138-1140)tGg>tTg	p.W380L	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.W381L|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.W384L			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	384	Peptidase S1.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						AATGAGATACCACGTATCTTT	0.383000													26	78					8.58068e-18	1.44431e-17	1	1	0
GPR88	54112	broad.mit.edu	37	1	101005398	101005398	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:101005398C>A	ENST00000315033.4	+	2	1315	c.876C>A	c.(874-876)gtC>gtA	p.V292V		NM_022049.2	NP_071332.2	Q9GZN0	GPR88_HUMAN	G protein-coupled receptor 88	292						integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|skin(1)	3		all_epithelial(167;1.19e-05)|all_lung(203;0.00159)|Lung NSC(277;0.00171)		Epithelial(280;0.0372)|all cancers(265;0.0558)|COAD - Colon adenocarcinoma(174;0.141)|Colorectal(144;0.156)|Lung(183;0.189)		TCTGCTGCGTCTTCCTGCTGG	0.756000													4	11					0.00116845	0.001285	1	1	0
PLEKHH2	130271	broad.mit.edu	37	2	43927656	43927656	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:43927656C>T	ENST00000282406.4	+	8	1669	c.1559C>T	c.(1558-1560)cCa>cTa	p.P520L		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	520						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TTGGACTCTCCAAATTCAGAT	0.428000													45	206					0	0	1	0	0
TMEM132E	124842	broad.mit.edu	37	17	32964803	32964803	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:32964803A>T	ENST00000321639.5	+	10	2835	c.2507A>T	c.(2506-2508)cAg>cTg	p.Q836L		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	836						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCCGAGGGCCAGACCAGCATG	0.652000													26	96					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736196	12736196	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:12736196C>A	ENST00000380682.1	+	16	3757	c.3251C>A	c.(3250-3252)aCt>aAt	p.T1084N		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1084					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CTGGAGAGAACTGCCTTTCGC	0.483000													43	124					1.32136e-16	2.19067e-16	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11593123	11593123	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:11593123C>A	ENST00000262442.3	+	20	4052	c.3984C>A	c.(3982-3984)aaC>aaA	p.N1328K	DNAH9_ENST00000454412.2_Missense_Mutation_p.N1328K	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1328	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGAATATCAACGTGGAAGCCA	0.567000													11	42					1.58986e-06	1.96395e-06	1	1	0
RTN4RL2	349667	broad.mit.edu	37	11	57243849	57243849	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:57243849C>T	ENST00000335099.3	+	3	1045	c.728C>T	c.(727-729)cCc>cTc	p.P243L		NM_178570.1	NP_848665.1	Q86UN3	R4RL2_HUMAN	reticulon 4 receptor-like 2	243					axon regeneration	anchored to plasma membrane	receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(2)	6						GCCTCGCTGCCCGGCGAGGCG	0.726000													5	26					0	0	1	0	0
MICALL2	79778	broad.mit.edu	37	7	1484460	1484460	+	Missense_Mutation	SNP	C	C	G	rs142930229		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:1484460C>G	ENST00000297508.7	-	6	1421	c.1246G>C	c.(1246-1248)Gcc>Ccc	p.A416P	MICALL2_ENST00000405088.4_Missense_Mutation_p.A204P	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	416						cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		TTATTCCGGGCCTGCTGGGTC	0.612000													4	29					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114257896	114257896	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:114257896G>T	ENST00000357077.4	+	31	3808	c.3755G>T	c.(3754-3756)gGg>gTg	p.G1252V	ANK2_ENST00000506722.1_Missense_Mutation_p.G1243V|ANK2_ENST00000264366.6_Missense_Mutation_p.G1219V|ANK2_ENST00000394537.3_Missense_Mutation_p.G1252V|ANK2_ENST00000509550.1_Missense_Mutation_p.G428V|ANK2_ENST00000504887.1_3'UTR	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1219					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AATGGTTTTGGGGGAGATGCA	0.398000													9	70					1.76689e-08	2.30533e-08	1	1	0
COG5	10466	broad.mit.edu	37	7	107188764	107188764	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:107188764C>A	ENST00000393603.2	-	4	670	c.399G>T	c.(397-399)atG>atT	p.M133I	COG5_ENST00000297135.3_Missense_Mutation_p.M133I|COG5_ENST00000347053.3_Missense_Mutation_p.M133I|COG5_ENST00000475638.2_5'UTR	NM_001161520.1	NP_001154992.1	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5	133					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|skin(4)|stomach(1)	40						TCGTCTGCATCATCTGAAGAA	0.328000													50	219					9.55421e-19	1.65232e-18	1	1	0
ARMC5	79798	broad.mit.edu	37	16	31473825	31473825	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:31473825C>T	ENST00000457010.2	+	3	1658	c.957C>T	c.(955-957)ggC>ggT	p.G319G	ARMC5_ENST00000268314.4_Silent_p.G319G|ARMC5_ENST00000412665.2_Intron|ARMC5_ENST00000408912.3_Silent_p.G414G|ARMC5_ENST00000538189.1_Silent_p.G351G|ARMC5_ENST00000563544.1_Silent_p.G319G	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	319							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						CTGCACTGGGCAATGCTGGTG	0.652000													18	54					0	0	1	0	0
OR10G4	390264	broad.mit.edu	37	11	123886891	123886891	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:123886891A>C	ENST00000320891.4	+	1	610	c.610A>C	c.(610-612)Ata>Cta	p.I204L		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GGACATTGGGATAGTGGCCTC	0.557000													55	211					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66356335	66356335	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:66356335C>A	ENST00000273854.3	-	5	1762	c.1162G>T	c.(1162-1164)Gac>Tac	p.D388Y	EPHA5_ENST00000432638.2_Intron|EPHA5_ENST00000354839.4_Missense_Mutation_p.D388Y|EPHA5_ENST00000511294.1_Missense_Mutation_p.D388Y	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	388	Fibronectin type-III 1.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TATGACACGTCTTTCCTTCCA	0.517000										TSP Lung(17;0.13)			8	82					0.00307968	0.00332877	1	1	0
COPG1	22820	broad.mit.edu	37	3	128969540	128969540	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:128969540C>A	ENST00000314797.6	+	2	157	c.53C>A	c.(52-54)cCa>cAa	p.P18Q		NM_016128.3	NP_057212.1	Q9Y678	COPG_HUMAN	coatomer protein complex, subunit gamma 1	18					COPI coating of Golgi vesicle|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol	protein binding|structural molecule activity										GGCTCCAACCCATTCCAGCAC	0.478000													16	81					8.60227e-14	1.3405e-13	1	1	0
OR5D13	390142	broad.mit.edu	37	11	55541710	55541710	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:55541710C>A	ENST00000361760.1	+	1	797	c.797C>A	c.(796-798)cCt>cAt	p.P266H		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	266					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				GTTCCTAATCCTAAAACTTCT	0.453000													11	79					0.000673444	0.000748083	1	1	0
E2F4	1874	broad.mit.edu	37	16	67228641	67228641	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:67228641C>T	ENST00000379378.3	+	6	625	c.566C>T	c.(565-567)cCc>cTc	p.P189L	E2F4_ENST00000564718.1_3'UTR	NM_001950.3	NP_001941.2	Q16254	E2F4_HUMAN	E2F transcription factor 4, p107/p130-binding	189					G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(4)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)	11		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		GTGAGTGGTCCCATTGAGGTT	0.537000													13	100					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123336763	123336763	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:123336763C>A	ENST00000296513.2	+	11	1664	c.1479C>A	c.(1477-1479)atC>atA	p.I493I	ADAD1_ENST00000388724.2_Silent_p.I482I|ADAD1_ENST00000388725.2_Silent_p.I475I	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	493	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						GTGGGAAGATCACTGAAAGGT	0.328000													17	133					7.07596e-05	8.14751e-05	1	1	0
TCHHL1	126637	broad.mit.edu	37	1	152058211	152058211	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:152058211G>A	ENST00000368806.1	-	3	2011	c.1947C>T	c.(1945-1947)ccC>ccT	p.P649P		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	649							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GGTGTCCATTGGGCTCCACAG	0.537000													37	171					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102196301	102196301	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:102196301C>A	ENST00000306176.1	+	11	1235	c.1135C>A	c.(1135-1137)Cct>Act	p.P379T	ZPLD1_ENST00000491959.1_Missense_Mutation_p.P363T|ZPLD1_ENST00000466937.1_Missense_Mutation_p.P363T	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	363						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						TCCAAGTATGCCTCCCTTCCA	0.448000													37	286					4.92203e-23	8.78791e-23	1	1	0
SALL3	27164	broad.mit.edu	37	18	76755364	76755364	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr18:76755364G>A	ENST00000536229.3	+	2	3467	c.2758G>A	c.(2758-2760)Gcc>Acc	p.A920T	SALL3_ENST00000575389.2_Missense_Mutation_p.A1053T|SALL3_ENST00000537592.2_Missense_Mutation_p.A1125T			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CTTCTCCTCGGCCAGCGCCCT	0.692000													2	6					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427667	135427667	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:135427667C>A	ENST00000394143.1	+	6	2093	c.1802C>A	c.(1801-1803)tCc>tAc	p.S601Y	GPR112_ENST00000370652.1_Missense_Mutation_p.S601Y|GPR112_ENST00000412101.1_Missense_Mutation_p.S396Y|GPR112_ENST00000287534.4_Missense_Mutation_p.S538Y|GPR112_ENST00000394141.1_Missense_Mutation_p.S396Y	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	601					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ATGCTTTCCTCCACAATCACA	0.453000													21	80					2.37509e-13	3.64953e-13	1	1	0
STIM1	6786	broad.mit.edu	37	11	4104591	4104591	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:4104591G>T	ENST00000300737.4	+	10	1906	c.1337G>T	c.(1336-1338)gGc>gTc	p.G446V	STIM1_ENST00000533977.1_Missense_Mutation_p.G273V|STIM1_ENST00000527651.1_Missense_Mutation_p.G446V	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	446					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		AACAACCCTGGCATCCACTCA	0.587000													15	36					1.05317e-09	1.42907e-09	1	1	0
ZCCHC14	23174	broad.mit.edu	37	16	87446138	87446138	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:87446138C>A	ENST00000268616.4	-	12	1995	c.1778G>T	c.(1777-1779)cGg>cTg	p.R593L		NM_015144.2	NP_055959.1	Q8WYQ9	ZCH14_HUMAN	zinc finger, CCHC domain containing 14	593					cell communication		nucleic acid binding|phosphatidylinositol binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	36				BRCA - Breast invasive adenocarcinoma(80;0.0285)		GACTTTGGTCCGGGGACCAAA	0.662000													8	63					1.12685e-05	1.35406e-05	1	1	0
RYR2	6262	broad.mit.edu	37	1	237664096	237664096	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:237664096C>A	ENST00000366574.2	+	21	2606	c.2289C>A	c.(2287-2289)gcC>gcA	p.A763A	RYR2_ENST00000360064.6_Silent_p.A761A|RYR2_ENST00000542537.1_Silent_p.A747A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	763	B30.2/SPRY 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATCTGAGTGCCCCAAGCATCT	0.428000													72	256					2.03652e-46	3.93906e-46	1	1	0
COL1A1	1277	broad.mit.edu	37	17	48266618	48266618	+	Missense_Mutation	SNP	C	C	A	rs72653160		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:48266618C>A	ENST00000225964.5	-	40	2966	c.2848G>T	c.(2848-2850)Ggg>Tgg	p.G950W		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	950	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	CCTTGAGGCCCGGGAGTACCA	0.642000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						13	27					2.27111e-07	2.88634e-07	1	1	0
ZNF658	26149	broad.mit.edu	37	9	40773136	40773136	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr9:40773136G>T	ENST00000602553.1	-	5	2433	c.2139C>A	c.(2137-2139)ccC>ccA	p.P713P	ZNF658_ENST00000377626.3_Silent_p.P713P|ZNF658_ENST00000441795.1_Intron			Q5TYW1	ZN658_HUMAN	zinc finger protein 658	713					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	46				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		TACATTCATAGGGTTTCTCCC	0.398000													48	385					1.47857e-17	2.46989e-17	1	1	0
MSH3	4437	broad.mit.edu	37	5	80083469	80083469	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:80083469G>A	ENST00000265081.6	+	18	2601	c.2521G>A	c.(2521-2523)Gct>Act	p.A841T		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	841					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GGCCAAGGTCGCTAAGCAAGG	0.378000								Mismatch excision repair (MMR)					5	110					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45645621	45645621	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:45645621G>T	ENST00000303230.4	-	2	572	c.515C>A	c.(514-516)aCa>aAa	p.T172K		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	172						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CCATGGTGTTGTTGTTTGCTC	0.353000													23	119					1.50039e-11	2.13443e-11	1	1	0
PROKR2	128674	broad.mit.edu	37	20	5283045	5283045	+	Silent	SNP	G	G	T	rs146729363		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:5283045G>T	ENST00000546004.1	-	3	1042	c.796C>A	c.(796-798)Cgg>Agg	p.R266R	PROKR2_ENST00000217270.3_Silent_p.R266R			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	266						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						CAGCGCAGCCGCTTGCGAATC	0.612000										HNSCC(71;0.22)			25	64					4.26978e-12	6.3187e-12	1	1	0
PTK7	5754	broad.mit.edu	37	6	43109462	43109462	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:43109462C>T	ENST00000230419.4	+	11	1896	c.1675C>T	c.(1675-1677)Cgg>Tgg	p.R559W	PTK7_ENST00000349241.2_Missense_Mutation_p.R429W|PTK7_ENST00000345201.2_Missense_Mutation_p.R519W|PTK7_ENST00000481273.1_Missense_Mutation_p.R567W|PTK7_ENST00000352931.2_Missense_Mutation_p.R559W	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	559	Ig-like C2-type 6.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GCATTTTGCCCGGGTGACTCG	0.587000													12	163					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75039073	75039073	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:75039073G>A	ENST00000326665.5	-	14	2539	c.2321C>T	c.(2320-2322)gCa>gTa	p.A774V	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	774	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TTCCTCCATTGCTTCTTTCTT	0.478000													31	129					0	0	1	0	0
GABRA4	2557	broad.mit.edu	37	4	46976307	46976307	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:46976307T>A	ENST00000264318.3	-	6	1645	c.663A>T	c.(661-663)ttA>ttT	p.L221F		NM_000809.3|NM_001204266.1|NM_001204267.1	NP_000800.2|NP_001191195.1|NP_001191196.1	P48169	GBRA4_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 4	221					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	45					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CATATTGAACTAAGCTGGAAG	0.403000													16	93					0	0	1	0	0
RIPK2	8767	broad.mit.edu	37	8	90777628	90777628	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:90777628C>T	ENST00000220751.4	+	3	701	c.387C>T	c.(385-387)gcC>gcT	p.A129A	RIPK2_ENST00000540020.1_5'UTR	NM_003821.5	NP_003812.1	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	129	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	10			BRCA - Breast invasive adenocarcinoma(11;0.0474)			ATGAAATTGCCCTTGGTGTAA	0.343000													23	117					0	0	1	0	0
DYRK1B	9149	broad.mit.edu	37	19	40317324	40317324	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:40317324T>A	ENST00000593685.1	-	9	1867	c.1399A>T	c.(1399-1401)Atc>Ttc	p.I467F	DYRK1B_ENST00000348817.3_Missense_Mutation_p.I439F|DYRK1B_ENST00000597639.1_Missense_Mutation_p.I439F|DYRK1B_ENST00000430012.2_Missense_Mutation_p.I427F|DYRK1B_ENST00000323039.5_Missense_Mutation_p.I467F			Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B	467					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(7)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	24	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			GAACTGGAGATGGAGCTGGCG	0.682000													3	6					0	0	1	0	0
WSCD1	23302	broad.mit.edu	37	17	6023892	6023892	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:6023892G>A	ENST00000574946.1	+	9	2029	c.1639G>A	c.(1639-1641)Gac>Aac	p.D547N	WSCD1_ENST00000539421.1_Missense_Mutation_p.D547N|WSCD1_ENST00000573634.1_Missense_Mutation_p.D431N|WSCD1_ENST00000574232.1_Missense_Mutation_p.D547N|WSCD1_ENST00000317744.5_Missense_Mutation_p.D547N			Q658N2	WSCD1_HUMAN	WSC domain containing 1	547						integral to membrane	sulfotransferase activity	p.D547Y(1)		breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)	35						GGAGATGAAAGACTTGATCAA	0.652000													37	69					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692376	20692376	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:20692376G>C	ENST00000315519.2	+	1	586	c.508G>C	c.(508-510)Gga>Cga	p.G170R		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		CTGGGTAGGCGGATTTCTCTG	0.498000													22	79					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059689	152059689	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:152059689C>A	ENST00000368806.1	-	3	533	c.469G>T	c.(469-471)Gtg>Ttg	p.V157L		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	157							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			CATGGGTCCACTCTGTTATTT	0.453000													36	158					4.17593e-13	6.3503e-13	1	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72055592	72055592	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:72055592G>C	ENST00000555818.1	+	2	1351	c.1003G>C	c.(1003-1005)Gat>Cat	p.D335H	SIPA1L1_ENST00000381232.3_Missense_Mutation_p.D335H|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.D335H	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	335					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		TGCCCACTATGATGTCCAGAG	0.448000													22	85					0	0	1	0	0
IGKV2D-24	28885	broad.mit.edu	37	2	90044140	90044140	+	RNA	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:90044140G>A	ENST00000462693.1	+	0	91																											ATCCAGTGGGGATATTGTGAT	0.433000													32	129					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166910553	166910553	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:166910553G>T	ENST00000061240.2	+	2	837	c.190G>T	c.(190-192)Gcc>Tcc	p.A64S	TLL1_ENST00000513213.1_Missense_Mutation_p.A64S|TLL1_ENST00000507499.1_Missense_Mutation_p.A64S	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	64					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GGGCGATATTGCCTTAGATGA	0.333000													7	89					0.00448238	0.00482129	1	1	0
PGK2	5232	broad.mit.edu	37	6	49754693	49754693	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:49754693C>A	ENST00000304801.3	-	1	360	c.208G>T	c.(208-210)Gtt>Ttt	p.V70F		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	70					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					GGCATGGGAACACCATCAGGC	0.502000													57	111					3.4597e-24	6.22746e-24	1	1	0
CFC1	55997	broad.mit.edu	37	2	131356238	131356238	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:131356238G>T	ENST00000259216.4	-	3	486	c.224C>A	c.(223-225)cCc>cAc	p.P75H		NM_032545.3	NP_115934.1	P0CG37	CFC1_HUMAN	cripto, FRL-1, cryptic family 1	75					determination of left/right symmetry|gastrulation	anchored to membrane|extracellular region|plasma membrane				endometrium(1)|lung(4)	5	Colorectal(110;0.1)					CCGGGAGTAGGGGAGCGGCTC	0.617000													13	134					1.5842e-08	2.07926e-08	1	1	0
OBSCN	84033	broad.mit.edu	37	1	228525812	228525812	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:228525812G>C	ENST00000570156.2	+	78	19913	c.19839G>C	c.(19837-19839)tgG>tgC	p.W6613C	OBSCN_ENST00000366709.4_Missense_Mutation_p.W2775C|OBSCN_ENST00000422127.1_Missense_Mutation_p.W5656C|OBSCN_ENST00000366707.4_Missense_Mutation_p.W3290C|OBSCN_ENST00000284548.11_Missense_Mutation_p.W5656C	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5656	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGCAGGGCTGGGTGTCACCAG	0.657000													10	24					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744773	140744773	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:140744773C>A	ENST00000518069.1	+	1	876	c.876C>A	c.(874-876)ttC>ttA	p.F292L	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGAGACTTTCCAACTTGATT	0.463000													19	48					7.07596e-05	8.14751e-05	1	1	0
RGS7	6000	broad.mit.edu	37	1	240990402	240990402	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:240990402C>A	ENST00000366565.1	-	10	1061	c.680G>T	c.(679-681)cGg>cTg	p.R227L	RGS7_ENST00000366564.1_Missense_Mutation_p.R227L|RGS7_ENST00000366562.4_Missense_Mutation_p.R227L|RGS7_ENST00000366563.1_Missense_Mutation_p.R227L|RGS7_ENST00000348120.2_Missense_Mutation_p.R174L|RGS7_ENST00000401882.1_Missense_Mutation_p.R174L|RGS7_ENST00000331110.7_Missense_Mutation_p.R201L|RGS7_ENST00000446183.2_Missense_Mutation_p.R143L|RGS7_ENST00000407727.1_Missense_Mutation_p.R227L	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	227					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TTTTACCTTCCGTGTTTTGTG	0.403000													9	81					2.17888e-05	2.5761e-05	1	1	0
LILRB1	10859	broad.mit.edu	37	19	55143941	55143941	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:55143941G>T	ENST00000396331.1	+	7	1045	c.688G>T	c.(688-690)Gtg>Ttg	p.V230L	LILRB1_ENST00000324602.7_Missense_Mutation_p.V230L|LILRB1_ENST00000396317.1_Missense_Mutation_p.V230L|LILRB1_ENST00000396315.1_Missense_Mutation_p.V230L|LILRB1_ENST00000396321.2_Missense_Mutation_p.V230L|LILRB1_ENST00000396327.3_Missense_Mutation_p.V230L|LILRB1_ENST00000434867.2_Missense_Mutation_p.V230L|LILRB1_ENST00000427581.2_Missense_Mutation_p.V266L|LILRB1_ENST00000396332.4_Missense_Mutation_p.V230L|LILRB1_ENST00000418536.2_Missense_Mutation_p.V230L|LILRB1_ENST00000448689.1_Missense_Mutation_p.V230L	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	230	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		ATCACTCTCAGTGCAGCCAGG	0.562000										HNSCC(37;0.09)			49	76					4.00472e-15	6.44555e-15	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141474386	141474386	+	Splice_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:141474386C>A	ENST00000389484.3	-	36	6730		c.e36-1			NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTATCATTTTCTATGGATAAG	0.343000										TSP Lung(27;0.18)			13	82					4.3838e-07	5.4922e-07	1	1	0
PCDHGA7	56108	broad.mit.edu	37	5	140763359	140763359	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:140763359C>A	ENST00000518325.1	+	1	893	c.893C>A	c.(892-894)aCa>aAa	p.T298K	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACTCGCTTACAGGAGAAATA	0.413000													17	45					1.5739e-10	2.16903e-10	1	1	0
TAS2R41	259287	broad.mit.edu	37	7	143175320	143175320	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:143175320T>A	ENST00000408916.1	+	1	355	c.355T>A	c.(355-357)Ttc>Atc	p.F119I	EPHA1-AS1_ENST00000429289.1_RNA	NM_176883.2	NP_795364.2	P59536	T2R41_HUMAN	taste receptor, type 2, member 41	119					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			endometrium(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(2)|skin(1)	18	Melanoma(164;0.15)					ACACTCCACCTTCCTGTGGCT	0.527000													11	77					0	0	1	0	0
HIST1H2AH	85235	broad.mit.edu	37	6	27115290	27115290	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:27115290A>C	ENST00000377459.1	+	1	430	c.383A>C	c.(382-384)aAa>aCa	p.K128T		NM_080596.1	NP_542163.1	Q96KK5	H2A1H_HUMAN	histone cluster 1, H2ah	128					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(7)|prostate(1)|skin(1)	12						CATAAGGCCAAATAAGGAGCG	0.488000													19	64					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76372327	76372327	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:76372327G>T	ENST00000407242.2	-	3	552	c.310C>A	c.(310-312)Ctg>Atg	p.L104M	LRRC32_ENST00000260061.5_Missense_Mutation_p.L104M|LRRC32_ENST00000404995.1_Missense_Mutation_p.L104M|AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000464145.1_Intron	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	104						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						TTGTGAGCCAGGCTGAGGTGC	0.642000													15	55					2.61681e-11	3.69877e-11	1	1	0
PCLO	27445	broad.mit.edu	37	7	82387993	82387993	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:82387993C>A	ENST00000333891.8	-	25	15664	c.15327G>T	c.(15325-15327)aaG>aaT	p.K5109N		NM_033026.5	NP_149015.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	5032					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CAATCAAGGTCTTTTTCATAA	0.328000													35	125					1.62565e-12	2.43021e-12	1	1	0
NEB	4703	broad.mit.edu	37	2	152484188	152484188	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:152484188C>A	ENST00000397345.3	-	69	10194	c.9992G>T	c.(9991-9993)aGc>aTc	p.S3331I	NEB_ENST00000427231.2_Missense_Mutation_p.S3331I|NEB_ENST00000409198.1_Missense_Mutation_p.S3088I|NEB_ENST00000604864.1_Missense_Mutation_p.S3331I|NEB_ENST00000172853.10_Missense_Mutation_p.S3088I|NEB_ENST00000603639.1_Missense_Mutation_p.S3331I	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	3331					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTCCACTGGGCTGCTGAACTT	0.527000													51	574					5.57489e-27	1.02439e-26	1	1	0
MDC1	9656	broad.mit.edu	37	6	30675381	30675381	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:30675381C>A	ENST00000376406.3	-	8	3622	c.2975G>T	c.(2974-2976)gGa>gTa	p.G992V	MDC1-AS1_ENST00000442150.1_RNA|MDC1_ENST00000376405.2_Intron	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	992				Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						GGATCCCCTTCCACCTGACTG	0.632000								Other conserved DNA damage response genes					27	110					7.26314e-15	1.16052e-14	1	1	0
TMX4	56255	broad.mit.edu	37	20	7964454	7964454	+	Silent	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:7964454T>C	ENST00000246024.2	-	7	881	c.666A>G	c.(664-666)ttA>ttG	p.L222L		NM_021156.2	NP_066979.2	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	222					cell redox homeostasis|electron transport chain|transport	integral to membrane				endometrium(3)|large_intestine(2)|lung(11)|skin(1)	17						AACGCTCAGATAAATGCCTTG	0.383000													4	56					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109767329	109767329	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:109767329C>A	ENST00000399132.1	-	28	2011	c.1481G>T	c.(1480-1482)gGt>gTt	p.G494V	COL25A1_ENST00000399127.1_Missense_Mutation_p.G467V|COL25A1_ENST00000399126.1_Missense_Mutation_p.G494V	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	494	Collagen-like 6.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TCCTTTTTCACCTGTCATACC	0.368000													11	107					3.86212e-05	4.49392e-05	1	1	0
UBE2D2	7322	broad.mit.edu	37	5	138994493	138994493	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:138994493C>A	ENST00000253815.2	+	6	1036	c.159C>A	c.(157-159)ggC>ggA	p.G53G	UBE2D2_ENST00000398733.3_Silent_p.G82G|UBE2D2_ENST00000511725.1_Silent_p.G53G|UBE2D2_ENST00000505548.1_Silent_p.G53G	NM_181838.1	NP_862821.1	P62837	UB2D2_HUMAN	ubiquitin-conjugating enzyme E2D 2	82					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|protein binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			ACAGTAATGGCAGCATTTGTC	0.328000													20	85					1.64113e-05	1.95605e-05	1	1	0
ZNF831	128611	broad.mit.edu	37	20	57766928	57766928	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:57766928T>C	ENST00000371030.2	+	1	854	c.854T>C	c.(853-855)aTg>aCg	p.M285T		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	285						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					TCTGCCCCCATGGCGTCACCT	0.662000													28	71					0	0	1	0	0
HELQ	113510	broad.mit.edu	37	4	84376611	84376611	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:84376611C>A	ENST00000295488.3	-	1	398	c.236G>T	c.(235-237)gGt>gTt	p.G79V	HELQ_ENST00000510985.1_Missense_Mutation_p.G79V|HELQ_ENST00000440639.2_5'UTR	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	79							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						TGTATCACCACCTCCAAGGAC	0.567000								Other identified genes with known or suspected DNA repair function					35	114					1.56442e-22	2.77072e-22	1	1	0
UGT2A3	79799	broad.mit.edu	37	4	69811098	69811098	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:69811098A>T	ENST00000251566.4	-	2	820	c.790T>A	c.(790-792)Ttt>Att	p.F264I	UGT2A3_ENST00000420231.2_5'UTR	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	264						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GGTTGAGGAAATTCAAAATCC	0.373000													14	50					0	0	1	0	0
APC	324	broad.mit.edu	37	5	112174935	112174935	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:112174935G>T	ENST00000457016.1	+	16	4024	c.3644G>T	c.(3643-3645)aGt>aTt	p.S1215I	CTC-554D6.1_ENST00000520401.1_Intron|APC_ENST00000508376.2_Missense_Mutation_p.S1215I|APC_ENST00000257430.4_Missense_Mutation_p.S1215I			P25054	APC_HUMAN	adenomatous polyposis coli	1215	Responsible for down-regulation through a process mediated by direct ubiquitination.|Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.K1192fs*3(1)|p.?(1)		NS(7)|adrenal_gland(6)|biliary_tract(5)|bone(6)|breast(29)|central_nervous_system(12)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(2768)|liver(15)|lung(39)|oesophagus(1)|ovary(12)|pancreas(27)|prostate(15)|salivary_gland(2)|skin(14)|small_intestine(34)|soft_tissue(55)|stomach(136)|thyroid(22)|upper_aerodigestive_tract(8)|urinary_tract(20)	3261		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		TCTTCAAGCAGTGAGAATACG	0.428000		12	"""D, Mis, N, F, S"""		"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""	"""colorectal, pancreatic, desmoid, hepatoblastoma, glioma, other CNS"""			Turcot syndrome;Hereditary Desmoid Disease;Familial Adenomatous Polyposis	TSP Lung(16;0.13)			25	80					1.64293e-13	2.54222e-13	1	1	0
INPP4B	8821	broad.mit.edu	37	4	143226669	143226669	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:143226669T>C	ENST00000513000.1	-	10	878	c.445A>G	c.(445-447)Agt>Ggt	p.S149G	INPP4B_ENST00000262992.4_Missense_Mutation_p.S149G|INPP4B_ENST00000509777.1_Missense_Mutation_p.S149G|INPP4B_ENST00000508116.1_Missense_Mutation_p.S149G|INPP4B_ENST00000308502.4_Missense_Mutation_p.S149G	NM_003866.2	NP_003857.2	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II, 105kDa	149	C2.				signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(29)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58	all_hematologic(180;0.158)					ACTTTAAAACTGGCATAGCCC	0.373000													68	260					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197026415	197026415	+	Splice_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:197026415C>A	ENST00000367412.1	-	6	1029		c.e6+1			NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide						blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						GTGTTACTAACCAATGCATTT	0.373000													33	112					2.85442e-18	4.87906e-18	1	1	0
DDR2	4921	broad.mit.edu	37	1	162688905	162688905	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:162688905T>A	ENST00000367922.2	+	4	490	c.52T>A	c.(52-54)Ttg>Atg	p.L18M	DDR2_ENST00000367921.3_Missense_Mutation_p.L18M	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	18					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GCTGCCTATCTTGAGTTCTGC	0.443000													28	115					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112022377	112022377	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:112022377T>A	ENST00000371959.3	-	10	3004	c.3005A>T	c.(3004-3006)cAg>cTg	p.Q1002L	AMOT_ENST00000371962.1_Missense_Mutation_p.Q770L|AMOT_ENST00000524145.1_Missense_Mutation_p.Q1002L|AMOT_ENST00000304758.1_Missense_Mutation_p.Q593L	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	1002					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						AGTTGGTGCCTGAGTCTGAGC	0.622000													8	71					0	0	1	0	0
TNNI3	7137	broad.mit.edu	37	19	55669072	55669072	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:55669072C>A	ENST00000587871.1	-	5	505	c.506G>T	c.(505-507)cGg>cTg	p.R169L	TNNI3_ENST00000344887.5_5'UTR|TNNI3_ENST00000590463.1_5'UTR																							CAGTCTCCTCCGGGCTGCTTG	0.627000													13	21					1.5842e-08	2.07926e-08	1	1	0
UPF3B	65109	broad.mit.edu	37	X	118975149	118975149	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:118975149T>A	ENST00000276201.2	-	7	766	c.697A>T	c.(697-699)Agg>Tgg	p.R233W	UPF3B_ENST00000478840.1_5'UTR|UPF3B_ENST00000345865.2_Missense_Mutation_p.R233W	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	233	Necessary for interaction with UPF2.|Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						catttcctcctctcttcttct	0.358000													14	69					0	0	1	0	0
ITSN1	6453	broad.mit.edu	37	21	35169790	35169790	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr21:35169790G>T	ENST00000381318.3	+	18	2348	c.2060G>T	c.(2059-2061)aGt>aTt	p.S687I	ITSN1_ENST00000399355.2_Missense_Mutation_p.S687I|ITSN1_ENST00000437442.2_Missense_Mutation_p.S687I|AP000304.12_ENST00000429238.1_Intron|ITSN1_ENST00000399349.1_Missense_Mutation_p.S687I|ITSN1_ENST00000399352.1_Missense_Mutation_p.S687I|ITSN1_ENST00000399353.1_Missense_Mutation_p.S650I|ITSN1_ENST00000399367.3_Missense_Mutation_p.S687I|ITSN1_ENST00000399326.3_Missense_Mutation_p.S687I|ITSN1_ENST00000399338.4_Missense_Mutation_p.S687I|ITSN1_ENST00000381285.4_Missense_Mutation_p.S687I|ITSN1_ENST00000381291.4_Missense_Mutation_p.S687I|ITSN1_ENST00000379960.5_Missense_Mutation_p.S687I	NM_003024.2	NP_003015.2	Q15811	ITSN1_HUMAN	intersectin 1 (SH3 domain protein)	687	KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(26)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	67						AGGGAGGAGAGTGTCAAAAAG	0.507000													27	87					7.16444e-05	8.22791e-05	1	1	0
FLNA	2316	broad.mit.edu	37	X	153585927	153585927	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:153585927G>T	ENST00000422373.1	-	29	5068	c.4820C>A	c.(4819-4821)gCc>gAc	p.A1607D	FLNA_ENST00000344736.4_Missense_Mutation_p.A1607D|FLNA_ENST00000360319.4_Missense_Mutation_p.A1607D|FLNA_ENST00000369856.3_5'UTR|FLNA_ENST00000369850.3_Missense_Mutation_p.A1607D	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	1607	Interaction with furin (By similarity).				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					TGGCACGTAGGCCACTGTATA	0.612000													6	51					3.59834e-05	4.23164e-05	1	1	0
PDE1C	5137	broad.mit.edu	37	7	31862692	31862692	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:31862692G>T	ENST00000396184.3	-	15	1781	c.1577C>A	c.(1576-1578)cCc>cAc	p.P526H	PDE1C_ENST00000396191.1_Missense_Mutation_p.P526H|PDE1C_ENST00000396193.1_Missense_Mutation_p.P586H|PDE1C_ENST00000396182.2_Missense_Mutation_p.P526H|PDE1C_ENST00000321453.7_Missense_Mutation_p.P526H	NM_005020.2	NP_005011.1	Q14123	PDE1C_HUMAN	phosphodiesterase 1C, calmodulin-dependent 70kDa	526					activation of phospholipase C activity|nerve growth factor receptor signaling pathway	cytosol	calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(38)|prostate(4)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	81			GBM - Glioblastoma multiforme(11;0.216)			GTTACCTTTGGGTACCTTGGC	0.453000													57	133					1.44317e-28	2.70824e-28	1	1	0
C1QC	714	broad.mit.edu	37	1	22974096	22974096	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:22974096C>A	ENST00000374639.3	+	3	676	c.558C>A	c.(556-558)ggC>ggA	p.G186G	C1QC_ENST00000374640.4_Silent_p.G186G|C1QC_ENST00000374637.1_Silent_p.G186G	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	186	C1q.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	ACCGCAGCGGCGTCAAAGTGG	0.602000													14	86					0.000151284	0.000172841	1	1	0
TGFBR2	7048	broad.mit.edu	37	3	30686267	30686267	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:30686267C>T	ENST00000295754.5	+	2	505	c.123C>T	c.(121-123)aaC>aaT	p.N41N	TGFBR2_ENST00000359013.4_Silent_p.N66N	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	41					activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						TCACTGACAACAACGGTGCAG	0.418000													8	31					0	0	1	0	0
MPP1	4354	broad.mit.edu	37	X	154007575	154007575	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:154007575G>A	ENST00000413259.3	-	13	1580	c.1188C>T	c.(1186-1188)taC>taT	p.Y396Y	MPP1_ENST00000393531.1_Silent_p.Y406Y|MPP1_ENST00000369534.3_Silent_p.Y426Y	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	426	Guanylate kinase-like.|Interaction with MPP5.				regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					AGTAGTGAGCGTACTGGCTGC	0.522000													13	83					0	0	1	0	0
OR2H1	26716	broad.mit.edu	37	6	29429912	29429912	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:29429912G>T	ENST00000377136.1	+	4	831	c.366G>T	c.(364-366)gtG>gtT	p.V122V	OR2H1_ENST00000473369.1_3'UTR|OR2H1_ENST00000396792.2_Silent_p.V122V|OR2H1_ENST00000377132.1_Silent_p.V122V|OR2H1_ENST00000377133.1_Silent_p.V122V|OR2H1_ENST00000442615.1_Silent_p.V122V			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						ACCGATACGTGGCTGTCTGCC	0.582000													14	204					9.05144e-12	1.31305e-11	1	1	0
MYO16	23026	broad.mit.edu	37	13	109817349	109817349	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr13:109817349G>C	ENST00000356711.2	+	33	5325	c.5199G>C	c.(5197-5199)caG>caC	p.Q1733H	MYO16_ENST00000357550.2_Missense_Mutation_p.Q1733H|MYO16-AS1_ENST00000439299.1_RNA	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1733					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATGGAATTCAGTTATCTAATT	0.338000													9	24					0	0	1	0	0
PHF20L1	51105	broad.mit.edu	37	8	133807010	133807010	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:133807010G>C	ENST00000395386.2	+	4	586	c.287G>C	c.(286-288)cGt>cCt	p.R96P	PHF20L1_ENST00000395390.2_Missense_Mutation_p.R96P|PHF20L1_ENST00000315808.10_Missense_Mutation_p.R96P|PHF20L1_ENST00000395376.1_Missense_Mutation_p.R96P|PHF20L1_ENST00000395383.1_Missense_Mutation_p.R96P|PHF20L1_ENST00000220847.7_5'UTR|PHF20L1_ENST00000337920.4_Missense_Mutation_p.R96P|PHF20L1_ENST00000395382.3_5'UTR|PHF20L1_ENST00000395379.1_Missense_Mutation_p.R96P	NM_016018.4	NP_057102.4	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1	96	Tudor 2.						nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(10)|ovary(2)	15	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			GTTCTGGCTCGTTGGACAGAC	0.313000													8	67					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131212990	131212990	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:131212990T>A	ENST00000298542.4	-	12	1230	c.1055A>T	c.(1054-1056)gAa>gTa	p.E352V	FRMD7_ENST00000370879.1_Missense_Mutation_p.E232V|FRMD7_ENST00000464296.1_Missense_Mutation_p.E337V	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	352					regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					TCTCAAATCTTCCACCTTGAG	0.463000													43	217					0	0	1	0	0
LOC643733	643733	broad.mit.edu	37	11	104774201	104774201	+	RNA	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:104774201G>A	ENST00000532510.1	-	0	3335																											GAAAGAGGTAGAAATATCTTG	0.413000													3	29					0	0	1	0	0
OPN1SW	611	broad.mit.edu	37	7	128415664	128415664	+	Missense_Mutation	SNP	G	G	T	rs62479596		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:128415664G>T	ENST00000249389.2	-	1	180	c.181C>A	c.(181-183)Cgc>Agc	p.R61S		NM_001708.2	NP_001699.1	P03999	OPSB_HUMAN	opsin 1 (cone pigments), short-wave-sensitive	61					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|stomach(1)	19						TTTTTGTAGCGCAGTGTGGCC	0.557000													35	139					3.11337e-16	5.12313e-16	1	1	0
CACNA1C	775	broad.mit.edu	37	12	2760899	2760899	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:2760899C>T	ENST00000399655.1	+	32	4304	c.4039C>T	c.(4039-4041)Cgg>Tgg	p.R1347W	CACNA1C_ENST00000399629.1_Missense_Mutation_p.R1364W|CACNA1C_ENST00000399603.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000399617.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000399597.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000399621.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000399591.1_Missense_Mutation_p.R1336W|CACNA1C_ENST00000327702.7_Missense_Mutation_p.R1347W|CACNA1C_ENST00000399649.1_Missense_Mutation_p.R1334W|CACNA1C_ENST00000399606.1_Missense_Mutation_p.R1367W|CACNA1C_ENST00000399644.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000344100.3_Missense_Mutation_p.R1369W|CACNA1C_ENST00000399595.1_Missense_Mutation_p.R1336W|CACNA1C_ENST00000399641.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000335762.5_Missense_Mutation_p.R1372W|CACNA1C_ENST00000399601.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000406454.3_Missense_Mutation_p.R1347W|CACNA1C_ENST00000399637.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000347598.4_Missense_Mutation_p.R1395W|CACNA1C_ENST00000399638.1_Missense_Mutation_p.R1375W|CACNA1C_ENST00000399634.1_Missense_Mutation_p.R1347W|CACNA1C_ENST00000402845.3_Missense_Mutation_p.R1347W	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1395					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGAGGGCATCCGGACGCTGCT	0.637000													18	40					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111412258	111412258	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:111412258C>T	ENST00000265162.5	+	3	1198	c.856C>T	c.(856-858)Ctg>Ttg	p.L286L		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	286					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	GAGCACGTACCTGGTGTGCTT	0.353000													22	102					0	0	1	0	0
LIFR	3977	broad.mit.edu	37	5	38489197	38489197	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:38489197A>G	ENST00000263409.4	-	16	2480	c.2318T>C	c.(2317-2319)aTg>aCg	p.M773T	LIFR_ENST00000453190.2_Missense_Mutation_p.M773T	NM_002310.5	NP_002301.1	P42702	LIFR_HUMAN	leukemia inhibitory factor receptor alpha	773	Fibronectin type-III 6.				positive regulation of cell proliferation	extracellular region|integral to plasma membrane	ciliary neurotrophic factor receptor binding|growth factor binding|leukemia inhibitory factor receptor activity			NS(2)|breast(4)|endometrium(6)|kidney(2)|large_intestine(30)|liver(2)|lung(21)|ovary(3)|skin(5)|stomach(1)|urinary_tract(2)	78	all_lung(31;0.00021)					TAAAACCCTCATCTTAGATGT	0.343000			T	PLAG1	salivary adenoma								17	76					0	0	1	0	0
CDKN1A	1026	broad.mit.edu	37	6	36652159	36652159	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:36652159G>C	ENST00000405375.1	+	2	516	c.281G>C	c.(280-282)cGg>cCg	p.R94P	CDKN1A_ENST00000373711.2_Missense_Mutation_p.R94P|CDKN1A_ENST00000448526.2_Missense_Mutation_p.R128P|CDKN1A_ENST00000478800.1_3'UTR|CDKN1A_ENST00000244741.5_Missense_Mutation_p.R94P	NM_001220778.1	NP_001207707.1	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	94					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|urinary_tract(5)	15						GGAGGCAGGCGGCCTGGCACC	0.672000													3	16					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11197459	11197459	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:11197459G>T	ENST00000337414.4	-	7	2315	c.1443C>A	c.(1441-1443)ctC>ctA	p.L481L	ARHGAP6_ENST00000413512.3_Silent_p.L290L|ARHGAP6_ENST00000380736.1_Silent_p.L278L|ARHGAP6_ENST00000534860.1_Silent_p.L306L|ARHGAP6_ENST00000303025.6_Silent_p.L278L|ARHGAP6_ENST00000491514.1_5'UTR|ARHGAP6_ENST00000380718.1_Silent_p.L481L|ARHGAP6_ENST00000380732.3_Silent_p.L513L	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	481	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GCTCCCTGGTGAGAAGGGGGT	0.502000													47	115					7.88023e-25	1.43012e-24	1	1	0
MATN1	4146	broad.mit.edu	37	1	31188898	31188898	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:31188898C>A	ENST00000373765.4	-	5	1100	c.1065G>T	c.(1063-1065)ggG>ggT	p.G355G	MATN1_ENST00000477320.1_5'UTR	NM_002379.3	NP_002370.1	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein	355	VWFA 2.				protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		TGAGAGCAGCCCCAGTCATTG	0.587000													16	147					1.99824e-07	2.54688e-07	1	1	0
SOCS5	9655	broad.mit.edu	37	2	46987117	46987117	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:46987117G>T	ENST00000306503.5	+	2	1620	c.1448G>T	c.(1447-1449)aGc>aTc	p.S483I	SOCS5_ENST00000394861.2_Missense_Mutation_p.S483I	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	483	SOCS box.				cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TTCCCTTTTAGCCTGCAGTAT	0.408000													6	107					0.00116845	0.001285	1	1	0
CARD11	84433	broad.mit.edu	37	7	2979403	2979403	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:2979403C>T	ENST00000396946.4	-	6	1247	c.844G>A	c.(844-846)Gag>Aag	p.E282K		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	282					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GACTGCAGCTCCTGGTTTTTG	0.572000			Mis		DLBCL								16	142					0	0	1	0	0
AEBP2	121536	broad.mit.edu	37	12	19646788	19646788	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:19646788C>A	ENST00000266508.9	+	4	1043	c.1042C>A	c.(1042-1044)Cat>Aat	p.H348N	AEBP2_ENST00000398864.3_Missense_Mutation_p.H348N|AEBP2_ENST00000541908.1_Missense_Mutation_p.H119N|AEBP2_ENST00000360995.4_Missense_Mutation_p.H132N	NM_153207.4	NP_694939.2	Q6ZN18	AEBP2_HUMAN	AE binding protein 2	348					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)|Esophageal squamous(101;0.143)					GCTAGCTCGTCATGTACCCAC	0.458000													11	24					0.00244969	0.00266745	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62291793	62291793	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:62291793T>A	ENST00000378024.4	-	5	10370	c.10096A>T	c.(10096-10098)Aca>Tca	p.T3366S	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3366					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ACTTCAGGTGTCTGAACTTTA	0.393000													14	103					0	0	1	0	0
CPSF3	51692	broad.mit.edu	37	2	9572793	9572793	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:9572793C>T	ENST00000460593.1	+	5	1522	c.384C>T	c.(382-384)ttC>ttT	p.F128F	CPSF3_ENST00000238112.3_Silent_p.F165F			Q9UKF6	CPSF3_HUMAN	cleavage and polyadenylation specific factor 3, 73kDa	165					histone mRNA 3'-end processing|mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex|ribonucleoprotein complex	5'-3' exonuclease activity|endoribonuclease activity|metal ion binding|protein binding|RNA binding			NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)	all_cancers(51;2.39e-25)|all_epithelial(98;8.75e-19)|Lung NSC(108;2.38e-06)|Ovarian(717;0.0308)		all cancers(51;2.2e-40)|Epithelial(75;6.71e-35)|OV - Ovarian serous cystadenocarcinoma(76;4.35e-21)|STAD - Stomach adenocarcinoma(1183;0.00644)		CCGCCATGTTCATGATTGAGA	0.453000													7	51					0	0	1	0	0
SASS6	163786	broad.mit.edu	37	1	100598311	100598311	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:100598311C>T	ENST00000287482.5	-	1	200	c.60G>A	c.(58-60)gaG>gaA	p.E20E	SASS6_ENST00000535161.1_5'UTR|SASS6_ENST00000462159.1_5'UTR	NM_194292.1	NP_919268.1	Q6UVJ0	SAS6_HUMAN	spindle assembly 6 homolog (C. elegans)	20					centriole replication	centriole				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	19		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		CTTACCTCTCCTCACAGTCTT	0.602000													11	147					0	0	1	0	0
SEMA3A	10371	broad.mit.edu	37	7	83590877	83590877	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:83590877A>G	ENST00000265362.3	-	17	2440	c.2126T>C	c.(2125-2127)cTc>cCc	p.L709P	SEMA3A_ENST00000436949.1_Missense_Mutation_p.L709P	NM_006080.2	NP_006071.1	Q14563	SEM3A_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	709					axon guidance	extracellular region|membrane	receptor activity			breast(3)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(22)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53						GTGGTTGATGAGCTGCATGAA	0.468000													12	134					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17434568	17434568	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:17434568G>C	ENST00000262545.2	+	9	1382	c.1067G>C	c.(1066-1068)aGc>aCc	p.S356T	PCSK2_ENST00000377899.1_Missense_Mutation_p.S337T|PCSK2_ENST00000536609.1_Missense_Mutation_p.S321T	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	356	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TCCACCTTCAGCAACGGGAGG	0.597000													16	69					0	0	1	0	0
KAT2A	2648	broad.mit.edu	37	17	40267775	40267775	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:40267775G>A	ENST00000225916.5	-	12	1894	c.1841C>T	c.(1840-1842)gCc>gTc	p.A614V		NM_021078.2	NP_066564.2	Q92830	KAT2A_HUMAN	K(lysine) acetyltransferase 2A	614	N-acetyltransferase.				chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						GTACTCGTCGGCGTAGGTGAG	0.572000													24	130					0	0	1	0	0
KRBA1	84626	broad.mit.edu	37	7	149427528	149427528	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:149427528C>T	ENST00000255992.10	+	16	2412	c.2013C>T	c.(2011-2013)cgC>cgT	p.R671R	KRBA1_ENST00000485033.2_Silent_p.R611R|KRBA1_ENST00000319551.8_Silent_p.R611R|KRBA1_ENST00000479560.1_3'UTR	NM_032534.2	NP_115923.2	A5PL33	KRBA1_HUMAN	KRAB-A domain containing 1	672	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(17)|ovary(1)|prostate(1)	27	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGAGGGACCGCCTTCCCAGCT	0.632000													3	12					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211456682	211456682	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:211456682C>A	ENST00000233072.5	+	10	1271	c.1075C>A	c.(1075-1077)Caa>Aaa	p.Q359K	CPS1_ENST00000430249.2_Missense_Mutation_p.Q365K	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	359	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TGTCAACGATCAAACAAATGA	0.378000													10	25					0.00829132	0.00883206	1	1	0
DOK6	220164	broad.mit.edu	37	18	67508509	67508509	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr18:67508509C>G	ENST00000382713.5	+	8	1076	c.886C>G	c.(886-888)Cgt>Ggt	p.R296G		NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	296							insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				AAAGATGTCTCGTGCACAGAC	0.502000													21	106					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23956664	23956664	+	Splice_Site	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:23956664G>C	ENST00000379211.3	+	8	1335	c.785_splice	c.e8-1	p.R262_splice		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	262										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						CATTTTCTAGGGGTCCATACT	0.333000													9	81					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55713565	55713565	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:55713565C>A	ENST00000376350.3	-	6	1034	c.1012G>T	c.(1012-1014)Ggt>Tgt	p.G338C	PTPRH_ENST00000263434.5_Missense_Mutation_p.G160C|PTPRH_ENST00000588559.1_5'UTR	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	338	Fibronectin type-III 4.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		GCTCTGCCACCATCTCCAGTG	0.577000													38	88					5.43694e-19	9.43972e-19	1	1	0
TRRAP	8295	broad.mit.edu	37	7	98508016	98508016	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:98508016G>T	ENST00000359863.4	+	15	1897	c.1688G>T	c.(1687-1689)gGc>gTc	p.G563V	TRRAP_ENST00000355540.3_Missense_Mutation_p.G563V|TRRAP_ENST00000446306.3_Missense_Mutation_p.G563V	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	563					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity	p.G563D(2)		NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			ATCACGTGGGGCATAACATCA	0.393000													37	166					6.03168e-27	1.10372e-26	1	1	0
IGSF10	285313	broad.mit.edu	37	3	151163060	151163060	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:151163060C>A	ENST00000282466.3	-	4	4708	c.4709G>T	c.(4708-4710)tGg>tTg	p.W1570L		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1570					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GTTTTCTGCCCAGGGAGATGG	0.428000													26	189					6.32553e-13	9.55328e-13	1	1	0
MAPK3	5595	broad.mit.edu	37	16	30133307	30133307	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:30133307C>A	ENST00000403394.1	-	2	290	c.191G>T	c.(190-192)cGc>cTc	p.R64L	MAPK3_ENST00000322266.5_Missense_Mutation_p.R64L|MAPK3_ENST00000484663.1_5'UTR|MAPK3_ENST00000395199.3_Missense_Mutation_p.R64L|MAPK3_ENST00000263025.4_Missense_Mutation_p.R64L|MAPK3_ENST00000395200.1_Missense_Mutation_p.R35L|MAPK3_ENST00000395202.1_Missense_Mutation_p.R64L	NM_001040056.1	NP_001035145.1	P27361	MK03_HUMAN	mitogen-activated protein kinase 3	64	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle|cellular response to mechanical stimulus|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|interleukin-1-mediated signaling pathway|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|Ras protein signal transduction|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription initiation from RNA polymerase I promoter	cytosol|nucleoplasm	ATP binding|MAP kinase activity|phosphatase binding									Arsenic trioxide(DB01169)|Isoproterenol(DB01064)|Simvastatin(DB00641)|Sulindac(DB00605)	GCGAGTCTTGCGCACGTGGTC	0.647000													18	50					2.37509e-13	3.64953e-13	1	1	0
BAG6	7917	broad.mit.edu	37	6	31615436	31615436	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:31615436C>G	ENST00000404765.2	-	7	1009	c.720G>C	c.(718-720)caG>caC	p.Q240H	BAG6_ENST00000211379.5_Missense_Mutation_p.Q240H|BAG6_ENST00000375964.6_Missense_Mutation_p.Q246H|BAG6_ENST00000439687.2_Missense_Mutation_p.Q240H|BAG6_ENST00000375976.4_Missense_Mutation_p.Q240H|BAG6_ENST00000362049.6_Missense_Mutation_p.Q240H			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	246	Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GCTCCGGGTTCTGGGCTGGGG	0.602000													45	129					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27497397	27497397	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:27497397C>A	ENST00000356183.4	-	24	3794	c.3779G>T	c.(3778-3780)cGg>cTg	p.R1260L	GTF3C1_ENST00000561623.1_Missense_Mutation_p.R1260L	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1260						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GACACGAAGCCGCGTCATCCG	0.567000													77	313					3.1711e-36	6.05391e-36	1	1	0
MYH14	79784	broad.mit.edu	37	19	50766619	50766619	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:50766619G>T	ENST00000440075.2	+	22	2683	c.2636G>T	c.(2635-2637)cGg>cTg	p.R879L	MYH14_ENST00000598205.1_Missense_Mutation_p.R846L|MYH14_ENST00000596571.1_Missense_Mutation_p.R838L|MYH14_ENST00000425460.1_Missense_Mutation_p.R846L|MYH14_ENST00000376970.2_Missense_Mutation_p.R871L|MYH14_ENST00000262269.8_Missense_Mutation_p.R879L|MYH14_ENST00000601313.1_Missense_Mutation_p.R879L			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	838					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GTGATGCAGCGGAACTGCGCG	0.657000													3	12					0.115264	0.116586	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25457182	25457182	+	RNA	SNP	C	C	A	rs149341231	by1000genomes	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:25457182C>A	ENST00000424208.1	+	0	2516				SNHG14_ENST00000450809.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						GCTCCCTGTGCGGGCTTGGTG	0.597000													7	21					0.00198382	0.00217088	1	1	0
TSIX	9383	broad.mit.edu	37	X	73045857	73045857	+	RNA	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:73045857C>A	ENST00000604411.1	+	0	33818				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCAGGGAGTTCAGGCTGTCCC	0.502000													43	173					1.62957e-23	2.9213e-23	1	1	0
ATG13	9776	broad.mit.edu	37	11	46670729	46670729	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:46670729G>A	ENST00000434074.1	+	5	1002	c.313G>A	c.(313-315)Gaa>Aaa	p.E105K	ATG13_ENST00000530500.1_Missense_Mutation_p.E26K|ATG13_ENST00000529655.1_Missense_Mutation_p.E105K|ATG13_ENST00000312040.4_Missense_Mutation_p.E105K|ATG13_ENST00000451945.1_Missense_Mutation_p.E105K|ATG13_ENST00000528494.1_Missense_Mutation_p.E105K|ATG13_ENST00000526508.1_Missense_Mutation_p.E105K|ATG13_ENST00000524625.1_Missense_Mutation_p.E105K|ATG13_ENST00000359513.4_Missense_Mutation_p.E105K	NM_001205120.1	NP_001192049.1	O75143	ATG13_HUMAN	autophagy related 13	105					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	15						TGAAATGAATGAAAAGTAAGT	0.363000													9	85					0	0	1	0	0
DXO	1797	broad.mit.edu	37	6	31939185	31939185	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:31939185C>T	ENST00000375349.3	-	2	679	c.268G>A	c.(268-270)Gat>Aat	p.D90N	DOM3Z_ENST00000478221.1_Intron|DOM3Z_ENST00000337523.5_Missense_Mutation_p.D90N|DOM3Z_ENST00000375356.3_Missense_Mutation_p.D90N			O77932	DOM3Z_HUMAN		90							identical protein binding|metal ion binding|nucleotide binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	7						TGGTATCGATCCGGGTATCCG	0.632000													5	49					0	0	1	0	0
PDE7B	27115	broad.mit.edu	37	6	136468596	136468596	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:136468596G>A	ENST00000308191.6	+	4	577	c.274G>A	c.(274-276)Gcc>Acc	p.A92T	RP13-143G15.4_ENST00000585946.1_RNA|RP13-143G15.4_ENST00000417643.1_RNA|RP13-143G15.4_ENST00000591521.1_RNA	NM_018945.3	NP_061818.1	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	92					signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	TATACCACAAGCCCCTCTGCA	0.498000													35	69					0	0	1	0	0
STX11	8676	broad.mit.edu	37	6	144508470	144508470	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:144508470G>T	ENST00000367568.4	+	2	889	c.706G>T	c.(706-708)Gag>Tag	p.E236*		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	236	t-SNARE coiled-coil homology.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GGTGCTGGTGGAGAAGCAGGC	0.637000									Familial Hemophagocytic Lymphohistiocytosis				8	37					1.26484e-09	1.7058e-09	1	1	0
SUGP2	10147	broad.mit.edu	37	19	19135690	19135690	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:19135690C>T	ENST00000601879.1	-	3	1764	c.1467G>A	c.(1465-1467)ttG>ttA	p.L489L	SUGP2_ENST00000337018.6_Silent_p.L489L|SUGP2_ENST00000456085.2_Silent_p.L258L|SUGP2_ENST00000452918.2_Silent_p.L489L|SUGP2_ENST00000600377.1_Silent_p.L503L			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	489					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						AAGAAGAGGCCAAGGAAAATG	0.512000													20	133					0	0	1	0	0
ARSH	347527	broad.mit.edu	37	X	2945415	2945415	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:2945415G>A	ENST00000381130.2	+	7	1098	c.1098G>A	c.(1096-1098)ccG>ccA	p.P366P		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	366						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TCCGGTGGCCGTCAGTCTTGG	0.507000													11	93					0	0	1	0	0
MALAT1	378938	broad.mit.edu	37	11	65271321	65271321	+	RNA	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:65271321C>T	ENST00000534336.1	+	0	6089					NR_002819.2																						TATAATAATTCCAGGCACATG	0.343000													9	34					0	0	1	0	0
OR7E24	26648	broad.mit.edu	37	19	9361881	9361881	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:9361881G>A	ENST00000456448.1	+	1	276	c.162G>A	c.(160-162)ctG>ctA	p.L54L		NM_001079935.1	NP_001073404.1	Q6IFN5	O7E24_HUMAN	olfactory receptor, family 7, subfamily E, member 24	54					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						CCATGTACCTGGTCACGGTGC	0.577000													10	63					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21231778	21231778	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:21231778G>T	ENST00000233242.1	-	26	8089	c.7962C>A	c.(7960-7962)aaC>aaA	p.N2654K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2654					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGTGGAAGGTGTTAAGGATGG	0.378000													51	229					3.10996e-30	5.88624e-30	1	1	0
CPQ	10404	broad.mit.edu	37	8	97797543	97797543	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:97797543G>T	ENST00000220763.5	+	2	628	c.418G>T	c.(418-420)Ggg>Tgg	p.G140W		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	140					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										CAGCAGCATTGGGACTCCTCC	0.423000													3	34					0.115264	0.116586	1	1	0
TSPYL6	388951	broad.mit.edu	37	2	54482785	54482785	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:54482785G>T	ENST00000317802.7	-	1	624	c.504C>A	c.(502-504)ggC>ggA	p.G168G	ACYP2_ENST00000606865.1_Intron|ACYP2_ENST00000394666.3_Intron|ACYP2_ENST00000607452.1_Intron|ACYP2_ENST00000303536.4_Intron	NM_001003937.2	NP_001003937.2	Q8N831	TSYL6_HUMAN	TSPY-like 6	168					nucleosome assembly	nucleus				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(1)|ovary(1)|skin(1)|stomach(2)	20						CCATTTCTTCGCCTCCTGGCT	0.612000													19	120					7.45023e-12	1.08434e-11	1	1	0
ALS2	57679	broad.mit.edu	37	2	202572615	202572615	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:202572615G>A	ENST00000264276.6	-	28	4752	c.4380C>T	c.(4378-4380)tcC>tcT	p.S1460S	ALS2_ENST00000457679.2_3'UTR	NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	1460					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						ATTCAGATCGGGAATCTGACT	0.493000													16	84					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692748	20692748	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:20692748C>G	ENST00000315519.2	+	1	958	c.880C>G	c.(880-882)Ctg>Gtg	p.L294V		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		GATCATCACTCTGGTATACAC	0.438000													33	130					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31682999	31682999	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:31682999G>T	ENST00000319386.3	+	11	2564	c.1571G>T	c.(1570-1572)gGa>gTa	p.G524V	CCDC129_ENST00000407970.3_Missense_Mutation_p.G672V|CCDC129_ENST00000409210.1_Missense_Mutation_p.G580V|CCDC129_ENST00000451887.2_Missense_Mutation_p.G698V			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	672										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						AAACTGCCTGGAGATCCTGCC	0.483000													16	79					0.000422831	0.000473271	1	1	0
OR10H2	26538	broad.mit.edu	37	19	15839311	15839311	+	Missense_Mutation	SNP	C	C	T	rs139469467		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:15839311C>T	ENST00000305899.3	+	1	478	c.458C>T	c.(457-459)tCg>tTg	p.S153L		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	153					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					GCTGGTGGCTCGGTCATGGGG	0.592000													7	70					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212566821	212566821	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:212566821T>A	ENST00000342788.4	-	12	1670	c.1360A>T	c.(1360-1362)Agc>Tgc	p.S454C	ERBB4_ENST00000402597.1_Missense_Mutation_p.S454C|ERBB4_ENST00000436443.1_Missense_Mutation_p.S454C	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	454					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		TTTCCTGCGCTGATTTCCTTC	0.448000										TSP Lung(8;0.080)			25	125					0	0	1	0	0
C9orf106	414318	broad.mit.edu	37	9	132084840	132084840	+	RNA	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr9:132084840G>T	ENST00000316786.1	+	0	801							Q8NAJ2	CI106_HUMAN	chromosome 9 open reading frame 106											large_intestine(1)|lung(1)|ovary(1)|skin(1)	4		Ovarian(14;0.00556)|Medulloblastoma(224;0.235)				GCACTGCCCAGAGCTCCTAAC	0.557000													17	46					2.48551e-13	3.80593e-13	1	1	0
MYH2	4620	broad.mit.edu	37	17	10428077	10428077	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:10428077G>T	ENST00000245503.5	-	34	5352	c.4968C>A	c.(4966-4968)ctC>ctA	p.L1656L	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000532183.1_Intron|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Silent_p.L1656L|CTC-297N7.7_ENST00000581304.1_RNA	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1656					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						TATTTACCTTGAGGATGCCTT	0.502000													40	120					6.04917e-29	1.14004e-28	1	1	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:7578212G>A	ENST00000420246.2	-	6	769	c.637C>T	c.(637-639)Cga>Tga	p.R213*	TP53_ENST00000574684.1_Intron|TP53_ENST00000269305.4_Nonsense_Mutation_p.R213*|TP53_ENST00000455263.2_Nonsense_Mutation_p.R213*|TP53_ENST00000413465.2_Nonsense_Mutation_p.R213*|TP53_ENST00000445888.2_Nonsense_Mutation_p.R213*|TP53_ENST00000359597.4_Nonsense_Mutation_p.R213*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	213	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(250)|p.R81*(21)|p.R120*(21)|p.0?(8)|p.?(5)|p.R213G(5)|p.R213fs*35(3)|p.R213fs*34(3)|p.D208_V216delDRNTFRHSV(1)|p.R120G(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R81fs*>11(1)|p.D208fs*1(1)|p.R120fs*35(1)|p.R81G(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	26					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66082815	66082815	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:66082815C>A	ENST00000311330.3	-	1	1700	c.1684G>T	c.(1684-1686)Ggt>Tgt	p.G562C	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	562	Pro-rich.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	AGCTGGGCACCGAGGGTGGTG	0.627000													11	81					0.00829132	0.00883206	1	1	0
LRP1	4035	broad.mit.edu	37	12	57594275	57594275	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:57594275C>T	ENST00000243077.3	+	63	10531	c.10065C>T	c.(10063-10065)acC>acT	p.T3355T		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	3355	LDL-receptor class A 21.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGTGTGACACCGAGGACGACT	0.652000													12	42					0	0	1	0	0
HLA-F-AS1	285830	broad.mit.edu	37	6	29713465	29713465	+	RNA	SNP	T	T	C	rs150074469	by1000genomes	TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:29713465T>C	ENST00000458236.1	-	0	133																											AGATCCATCCTGGGACAGCAC	0.532000													4	63					0	0	1	0	0
OR10G2	26534	broad.mit.edu	37	14	22102443	22102443	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:22102443T>A	ENST00000542433.1	-	1	653	c.556A>T	c.(556-558)Atc>Ttc	p.I186F		NM_001005466.1	NP_001005466.1	Q8NGC3	O10G2_HUMAN	olfactory receptor, family 10, subfamily G, member 2	186					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)|stomach(2)	22	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0142)		ACTGCGCGGATGTCACAGATA	0.547000													39	173					0	0	1	0	0
PGLS	25796	broad.mit.edu	37	19	17627041	17627041	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:17627041G>A	ENST00000252603.2	+	2	392	c.348G>A	c.(346-348)gaG>gaA	p.E116E		NM_012088.2	NP_036220.1	O95336	6PGL_HUMAN	6-phosphogluconolactonase	116						cytosol	6-phosphogluconolactonase activity			endometrium(1)|lung(1)	2						TTAACCCCGAGCTGCCTGTGG	0.597000													4	45					0	0	1	0	0
NEURL4	84461	broad.mit.edu	37	17	7226286	7226286	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:7226286C>A	ENST00000399464.2	-	15	2589	c.2574G>T	c.(2572-2574)tcG>tcT	p.S858S	NEURL4_ENST00000315614.7_Silent_p.S858S|NEURL4_ENST00000570460.1_Silent_p.S836S	NM_032442.2	NP_115818.2			neuralized E3 ubiquitin protein ligase 4											central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GAGGCAGGCCCGAGCAGGCAG	0.627000													19	58					3.32936e-07	4.20701e-07	1	1	0
COL6A3	1293	broad.mit.edu	37	2	238277462	238277462	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:238277462C>A	ENST00000295550.4	-	10	5096	c.4644G>T	c.(4642-4644)ctG>ctT	p.L1548L	COL6A3_ENST00000409809.1_Silent_p.L1342L|COL6A3_ENST00000347401.3_Silent_p.L1347L|COL6A3_ENST00000472056.1_Silent_p.L941L|COL6A3_ENST00000346358.4_Silent_p.L1348L|COL6A3_ENST00000353578.4_Silent_p.L1342L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1548	Nonhelical region.|VWFA 8.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ATTTTCCACCCAGGACCAGGA	0.557000													14	141					6.81908e-15	1.09353e-14	1	1	0
KCNT2	343450	broad.mit.edu	37	1	196295871	196295871	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:196295871G>C	ENST00000367433.5	-	19	2353	c.2252C>G	c.(2251-2253)cCc>cGc	p.P751R	KCNT2_ENST00000294725.8_Missense_Mutation_p.P751R|KCNT2_ENST00000451324.2_Missense_Mutation_p.P362R|KCNT2_ENST00000367431.4_Missense_Mutation_p.P701R|KCNT2_ENST00000498426.1_Intron			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	751						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CAGTACTATGGGATTAAGTTC	0.289000													17	80					0	0	1	0	0
LOC645166	645166	broad.mit.edu	37	1	148932819	148932819	+	RNA	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:148932819G>T	ENST00000539543.1	+	0	75					NR_027355.1																						AGCCCGCCAGGCCTCCATAGA	0.597000													12	173					2.32078e-09	3.09204e-09	1	1	0
NAV3	89795	broad.mit.edu	37	12	78400687	78400687	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:78400687A>G	ENST00000397909.2	+	8	1542	c.1369A>G	c.(1369-1371)Agc>Ggc	p.S457G	NAV3_ENST00000228327.6_Missense_Mutation_p.S457G|NAV3_ENST00000266692.7_Missense_Mutation_p.S457G|NAV3_ENST00000536525.2_Missense_Mutation_p.S457G			Q8IVL0	NAV3_HUMAN	neuron navigator 3	457						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CAAAAATCTCAGCAATAAAAA	0.403000										HNSCC(70;0.22)			28	58					0	0	1	0	0
PCDHGA11	56105	broad.mit.edu	37	5	140800903	140800903	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:140800903C>A	ENST00000398587.2	+	1	142	c.109C>A	c.(109-111)Cca>Aca	p.P37T	PCDHGA10_ENST00000398610.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA11_ENST00000518882.1_Missense_Mutation_p.P37T|PCDHGB7_ENST00000398594.2_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018914.2|NM_032092.1	NP_061737.1|NP_114481.1														breast(3)|endometrium(8)|kidney(3)|large_intestine(9)|lung(22)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATATTCGGTGCCAGAAGAGAC	0.657000													21	39					2.54575e-18	4.36838e-18	1	1	0
KLRF1	51348	broad.mit.edu	37	12	9997060	9997060	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:9997060A>G	ENST00000279544.3	+	6	698	c.634A>G	c.(634-636)Att>Gtt	p.I212V	KLRF1_ENST00000354855.3_3'UTR|KLRF1_ENST00000324214.4_Missense_Mutation_p.I162V|KLRF1_ENST00000537723.1_3'UTR	NM_016523.1	NP_057607.1	Q9NZS2	KLRF1_HUMAN	killer cell lectin-like receptor subfamily F, member 1	212	C-type lectin.				cell surface receptor linked signaling pathway	integral to plasma membrane	MHC class I receptor activity|sugar binding			breast(1)|endometrium(2)|large_intestine(4)|lung(6)	13						CTGTGCTGCCATTAAGGAAAG	0.348000													6	38					0	0	1	0	0
TRAM1	23471	broad.mit.edu	37	8	71496019	71496019	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:71496019C>A	ENST00000521425.1	-	9	1534	c.498G>T	c.(496-498)ctG>ctT	p.L166L	TRAM1_ENST00000521049.1_5'UTR|TRAM1_ENST00000536748.1_Silent_p.L221L|TRAM1_ENST00000262213.2_Silent_p.L252L			Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	252	TLC.				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)	17			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			GAACTGCCCACAGAGAAAATC	0.388000													17	113					3.41278e-10	4.67403e-10	1	1	0
TRPV2	51393	broad.mit.edu	37	17	16326026	16326026	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:16326026C>A	ENST00000338560.7	+	4	847	c.448C>A	c.(448-450)Ccc>Acc	p.P150T	TRPV2_ENST00000577397.1_5'UTR	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	150	Required for interaction with SLC50A1 (By similarity).				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CAATCCTCAGCCCCTGGTAAA	0.547000													11	14					0.0809354	0.0830058	1	1	0
GPR112	139378	broad.mit.edu	37	X	135432283	135432283	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:135432283C>G	ENST00000394143.1	+	6	6709	c.6418C>G	c.(6418-6420)Cta>Gta	p.L2140V	GPR112_ENST00000370652.1_Missense_Mutation_p.L2140V|GPR112_ENST00000412101.1_Missense_Mutation_p.L1935V|GPR112_ENST00000287534.4_Missense_Mutation_p.L2077V|GPR112_ENST00000394141.1_Missense_Mutation_p.L1935V	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	2140					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TGACCACACTCTATCTGTTGG	0.458000													31	87					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236208816	236208816	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:236208816C>G	ENST00000264187.6	-	3	775	c.693G>C	c.(691-693)aaG>aaC	p.K231N	NID1_ENST00000366595.3_Missense_Mutation_p.K231N	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	231	NIDO.				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	CTCCGTTGCTCTTCCATAAGA	0.403000													9	120					0	0	1	0	0
GJA10	84694	broad.mit.edu	37	6	90605651	90605651	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:90605651C>A	ENST00000369352.1	+	1	1464	c.1464C>A	c.(1462-1464)atC>atA	p.I488I		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	488					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		CCCTACCGATCATGGAACTAT	0.483000													39	93					1.59932e-28	2.98857e-28	1	1	0
LRFN5	145581	broad.mit.edu	37	14	42356987	42356987	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:42356987A>T	ENST00000554171.1	+	5	3591	c.1159A>T	c.(1159-1161)Atc>Ttc	p.I387F	LRFN5_ENST00000554120.1_Missense_Mutation_p.I387F|LRFN5_ENST00000298119.4_Missense_Mutation_p.I387F			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	387						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TACAAACCATATCCATGAGCC	0.383000										HNSCC(30;0.082)			21	83					0	0	1	0	0
ZNF791	163049	broad.mit.edu	37	19	12739540	12739540	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:12739540G>C	ENST00000343325.4	+	4	1359	c.1197G>C	c.(1195-1197)ttG>ttC	p.L399F	ZNF490_ENST00000465656.1_Intron|ZNF791_ENST00000540038.1_Missense_Mutation_p.L290F|ZNF791_ENST00000458122.3_Missense_Mutation_p.L367F|ZNF791_ENST00000446165.1_3'UTR	NM_153358.2	NP_699189.2	Q3KP31	ZN791_HUMAN	zinc finger protein 791	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						CTCTAGATTTGAAAATCCACA	0.363000													6	127					0	0	1	0	0
STK17A	9263	broad.mit.edu	37	7	43647877	43647877	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:43647877G>C	ENST00000319357.5	+	3	621	c.442G>C	c.(442-444)Gac>Cac	p.D148H	STK17A_ENST00000462448.1_3'UTR	NM_004760.2	NP_004751.2	Q9UEE5	ST17A_HUMAN	serine/threonine kinase 17a	148	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	nucleus	ATP binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						TGAAATCTTTGACCAGTGTGT	0.368000													9	85					0	0	1	0	0
SLAMF7	57823	broad.mit.edu	37	1	160722919	160722919	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:160722919C>G	ENST00000359331.4	+	6	867	c.856C>G	c.(856-858)Cac>Gac	p.H286D	SLAMF7_ENST00000441662.2_Silent_p.L189L|SLAMF7_ENST00000458602.2_Silent_p.L173L|SLAMF7_ENST00000368042.3_Silent_p.L213L|SLAMF7_ENST00000458104.2_Missense_Mutation_p.H139D|SLAMF7_ENST00000368043.3_Silent_p.L320L|SLAMF7_ENST00000444090.2_Missense_Mutation_p.H155D			Q9NQ25	SLAF7_HUMAN	SLAM family member 7	0					cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			ACTCACTGCTCACGATGCCAG	0.483000													27	72					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107745023	107745023	+	Silent	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:107745023C>G	ENST00000388781.3	-	9	995	c.912G>C	c.(910-912)ccG>ccC	p.P304P	LAMB4_ENST00000388780.3_Silent_p.P304P|LAMB4_ENST00000414450.2_Silent_p.P304P|LAMB4_ENST00000205386.4_Silent_p.P304P	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	304	Laminin EGF-like 1.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TCTCACAGTTCGGACCATCTG	0.522000													43	216					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19856820	19856820	+	RNA	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:19856820C>A	ENST00000548109.1	+	0	72																											TTATACTTTCCTAACAGACAA	0.323000													6	64					0.0293803	0.0304864	1	1	0
PITX3	5309	broad.mit.edu	37	10	103990315	103990315	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:103990315C>T	ENST00000370002.3	-	4	1018	c.865G>A	c.(865-867)Gcc>Acc	p.A289T	PITX3_ENST00000539804.1_Missense_Mutation_p.A289T	NM_005029.3	NP_005020.1	O75364	PITX3_HUMAN	paired-like homeodomain 3	289					dopaminergic neuron differentiation|lens morphogenesis in camera-type eye|midbrain development|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(2)	5		Colorectal(252;0.00957)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CTAAGGTTGGCTGCCGGGGGC	0.677000													3	10					0	0	1	0	0
GJA9	81025	broad.mit.edu	37	1	39341093	39341093	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:39341093G>T	ENST00000454994.2	-	2	954	c.678C>A	c.(676-678)aaC>aaA	p.N226K	GJA9_ENST00000360786.3_Missense_Mutation_p.N226K|MYCBP_ENST00000489803.1_5'UTR|RP5-864K19.4_ENST00000443161.1_RNA|GJA9_ENST00000357771.3_Missense_Mutation_p.N226K|RP5-864K19.4_ENST00000433671.2_RNA|RP5-864K19.4_ENST00000456813.1_RNA			P57773	CXA9_HUMAN	gap junction protein, alpha 9, 59kDa	226					cell communication	connexon complex|integral to membrane				breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			TTTCAAGAATGTTTAAGAAAA	0.323000													11	75					3.86212e-05	4.49392e-05	1	1	0
MBL2	4153	broad.mit.edu	37	10	54529050	54529050	+	Silent	SNP	T	T	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:54529050T>G	ENST00000373968.3	-	3	394	c.330A>C	c.(328-330)tcA>tcC	p.S110S	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	110					acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						CTTTTCTTTCTGAGGCAGCCA	0.408000													8	112					0	0	1	0	0
RHOT2	89941	broad.mit.edu	37	16	722738	722738	+	Silent	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:722738A>T	ENST00000315082.4	+	17	1554	c.1440A>T	c.(1438-1440)acA>acT	p.T480T		NM_138769.2	NP_620124.1	Q8IXI1	MIRO2_HUMAN	ras homolog family member T2	480	Miro 2.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|pancreas(2)|prostate(1)	13		Hepatocellular(780;0.0218)				TGCTGGCCACATCGCTGGACG	0.622000													21	46					0	0	1	0	0
OR4C11	219429	broad.mit.edu	37	11	55371305	55371305	+	Nonsense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:55371305A>T	ENST00000302231.4	-	1	569	c.545T>A	c.(544-546)tTg>tAg	p.L182*		NM_001004700.2	NP_001004700.2	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C, member 11	182					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|prostate(1)|skin(1)	33						AAGTTTCAACAAGGGCTGCAA	0.408000													11	112					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12735831	12735831	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:12735831C>A	ENST00000380682.1	+	16	3392	c.2886C>A	c.(2884-2886)ggC>ggA	p.G962G		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	962					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CCGCTGGGGGCTTGCCTCCAA	0.612000													41	138					9.14704e-12	1.32257e-11	1	1	0
NYNRIN	57523	broad.mit.edu	37	14	24877490	24877490	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:24877490G>T	ENST00000382554.3	+	3	932	c.614G>T	c.(613-615)tGg>tTg	p.W205L		NM_025081.2	NP_079357.2	Q9P2P1	NYNRI_HUMAN	NYN domain and retroviral integrase containing	205					DNA integration	integral to membrane	DNA binding			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(8)|lung(21)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	56						ATCATCGAGTGGCTCAGCCGC	0.642000													11	37					3.86212e-05	4.49392e-05	1	1	0
MTHFD1	4522	broad.mit.edu	37	14	64905885	64905885	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:64905885C>T	ENST00000555709.1	+	17	2056	c.1669C>T	c.(1669-1671)Cgg>Tgg	p.R557W	MTHFD1_ENST00000216605.7_Missense_Mutation_p.R613W|MTHFD1_ENST00000555252.1_Missense_Mutation_p.R537W|MTHFD1_ENST00000545908.1_Missense_Mutation_p.R613W|CTD-2555O16.2_ENST00000556640.1_RNA	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	557	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GGGTCACACACGGACGGTAAC	0.473000													4	35					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3672676	3672676	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:3672676C>T	ENST00000344754.4	-	16	4203	c.4204G>A	c.(4204-4206)Gtc>Atc	p.V1402I	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.V1402I	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1402	Ig-like C2-type 14.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GCCACCTGGACATGGCCTGTC	0.597000													4	37					0	0	1	0	0
FSHR	2492	broad.mit.edu	37	2	49295429	49295429	+	Splice_Site	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:49295429C>G	ENST00000406846.2	-	2	272	c.152_splice	c.e2-1	p.L51_splice	FSHR_ENST00000346173.3_Splice_Site_p.L51_splice|FSHR_ENST00000304421.4_Splice_Site_p.L51_splice	NM_000145.3	NP_000136.2	P23945	FSHR_HUMAN	follicle stimulating hormone receptor	51					female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(10)|liver(1)|lung(45)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	73		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	GGACAAACCTCCTGCAAAGAG	0.378000									Gonadal Dysgenesis, 46 XX				20	104					0	0	1	0	0
MTNR1B	4544	broad.mit.edu	37	11	92714834	92714834	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:92714834C>T	ENST00000257068.2	+	2	451	c.445C>T	c.(445-447)Cac>Tac	p.H149Y		NM_005959.3	NP_005950.1	P49286	MTR1B_HUMAN	melatonin receptor 1B	149					G-protein signaling, coupled to cyclic nucleotide second messenger|glucose homeostasis|regulation of insulin secretion|synaptic transmission	integral to plasma membrane	melatonin receptor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	33		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)			Ramelteon(DB00980)	CATGGCCTACCACCGAATCTA	0.587000													22	74					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	79991526	79991526	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:79991526A>T	ENST00000373275.4	-	9	1091	c.875T>A	c.(874-876)aTc>aAc	p.I292N		NM_153252.4	NP_694984.4	Q6RI45	BRWD3_HUMAN	bromodomain and WD repeat domain containing 3	292										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						CCAGAAACAGATTGTTCCATC	0.294000													7	46					0	0	1	0	0
PCDH7	5099	broad.mit.edu	37	4	30725013	30725013	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr4:30725013C>A	ENST00000361762.2	+	1	2977	c.1969C>A	c.(1969-1971)Cct>Act	p.P657T	PCDH7_ENST00000543491.1_Missense_Mutation_p.P657T	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	657	Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						GCCCAACAGCCCTGTGGGGAT	0.443000													47	121					1.48734e-19	2.59255e-19	1	1	0
FILIP1	27145	broad.mit.edu	37	6	76063367	76063367	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:76063367C>T	ENST00000393004.2	-	4	738	c.517G>A	c.(517-519)Gag>Aag	p.E173K	FILIP1_ENST00000370020.1_Missense_Mutation_p.E74K|FILIP1_ENST00000237172.7_Missense_Mutation_p.E173K			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	173										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						TGACACTTCTCGGCCAGCAAC	0.478000													27	93					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78593173	78593173	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:78593173C>A	ENST00000397909.2	+	37	6750	c.6577C>A	c.(6577-6579)Cga>Aga	p.R2193R	NAV3_ENST00000228327.6_Silent_p.R2171R|NAV3_ENST00000266692.7_Silent_p.R1994R|NAV3_ENST00000541270.1_Silent_p.R23R|NAV3_ENST00000536525.2_Silent_p.R2171R			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2193						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.R2171*(1)		NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CAGATATCTTCGAAGAAAACT	0.323000										HNSCC(70;0.22)			25	67					4.87955e-14	7.65795e-14	1	1	0
AOC1	26	broad.mit.edu	37	7	150557663	150557663	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:150557663G>T	ENST00000493429.1	+	6	2515	c.1931G>T	c.(1930-1932)tGg>tTg	p.W644L	AOC1_ENST00000480582.1_3'UTR|AOC1_ENST00000467291.1_Missense_Mutation_p.W644L|AOC1_ENST00000416793.2_Missense_Mutation_p.W663L|AOC1_ENST00000360937.4_Missense_Mutation_p.W644L					amine oxidase, copper containing 1																		AACGACCCCTGGCACCCGCCC	0.612000													33	103					2.80507e-11	3.95219e-11	1	1	0
NRG3	10718	broad.mit.edu	37	10	83635849	83635849	+	Silent	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:83635849C>A	ENST00000404547.1	+	1	753	c.753C>A	c.(751-753)gcC>gcA	p.A251A	NRG3_ENST00000372141.2_Silent_p.A251A			P56975	NRG3_HUMAN	neuregulin 3	251	Ser/Thr-rich.				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(41)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	69				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AGGATGCTGcctcctcttctt	0.537000													4	21					0.00909568	0.0096423	1	1	0
ZC3HC1	51530	broad.mit.edu	37	7	129663356	129663356	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:129663356T>A	ENST00000358303.4	-	8	1312	c.1228A>T	c.(1228-1230)Agt>Tgt	p.S410C	RP11-306G20.1_ENST00000587038.1_RNA|RP11-306G20.1_ENST00000480018.1_RNA|ZC3HC1_ENST00000311873.5_Missense_Mutation_p.S389C|ZC3HC1_ENST00000360708.5_Intron|ZC3HC1_ENST00000481503.1_Missense_Mutation_p.S367C	NM_016478.3	NP_057562.3	Q86WB0	NIPA_HUMAN	zinc finger, C3HC-type containing 1	410					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding			endometrium(2)|kidney(6)|large_intestine(10)|lung(2)|prostate(1)|urinary_tract(1)	22	Melanoma(18;0.0435)					CTCACCGAACTGCTGGAGGAG	0.612000													29	127					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76532478	76532478	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:76532478G>T	ENST00000307431.8	+	16	2634	c.2249G>T	c.(2248-2250)gGa>gTa	p.G750V	CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Missense_Mutation_p.G702V|CNTNAP4_ENST00000476707.1_Missense_Mutation_p.G754V|CNTNAP4_ENST00000478060.1_Missense_Mutation_p.G678V	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	751	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AATGACACTGGATTGCTTGCT	0.373000													14	36					9.31168e-06	1.12815e-05	1	1	0
FOXP2	93986	broad.mit.edu	37	7	114066584	114066584	+	Silent	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:114066584G>A	ENST00000408937.3	+	2	392	c.18G>A	c.(16-18)gcG>gcA	p.A6A	FOXP2_ENST00000459666.1_3'UTR|FOXP2_ENST00000403559.4_Silent_p.A6A|FOXP2_ENST00000462331.1_Silent_p.A6A|FOXP2_ENST00000393494.2_Silent_p.A6A|FOXP2_ENST00000393500.3_5'UTR|FOXP2_ENST00000393498.2_Silent_p.A6A|FOXP2_ENST00000360232.4_Silent_p.A6A|FOXP2_ENST00000350908.4_Silent_p.A6A|FOXP2_ENST00000393489.3_5'UTR|FOXP2_ENST00000378237.3_Silent_p.A6A|FOXP2_ENST00000390668.3_Silent_p.A5A	NM_001172766.2|NM_014491.3|NM_148898.3	NP_001166237.1|NP_055306.1|NP_683696.2	O15409	FOXP2_HUMAN	forkhead box P2	6					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						AGGAATCTGCGACAGAGACAA	0.398000													5	71					0	0	1	0	0
PITPNM3	83394	broad.mit.edu	37	17	6387018	6387018	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:6387018C>A	ENST00000262483.8	-	6	493	c.406G>T	c.(406-408)Ggg>Tgg	p.G136W	ACKR6_ENST00000421306.3_Missense_Mutation_p.G100W	NM_031220.3	NP_112497.2																					ATGTTTCCCCCATGCAGGACC	0.627000													18	48					1.01871e-10	1.40831e-10	1	1	0
NMUR2	56923	broad.mit.edu	37	5	151771933	151771933	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:151771933T>C	ENST00000255262.3	-	4	1232	c.1067A>G	c.(1066-1068)cAg>cGg	p.Q356R		NM_020167.4	NP_064552.3	Q9GZQ4	NMUR2_HUMAN	neuromedin U receptor 2	356					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|arachidonic acid secretion|calcium ion transport|central nervous system development|elevation of cytosolic calcium ion concentration|regulation of smooth muscle contraction	integral to membrane|plasma membrane	GTP binding|intracellular calcium activated chloride channel activity|neuromedin U receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(12)|liver(1)|lung(15)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	44		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)	Kidney(363;0.000106)|KIRC - Kidney renal clear cell carcinoma(527;0.000672)			AGGTGGCAACTGTGGGTCATG	0.512000													40	97					0	0	1	0	0
ZC3H3	23144	broad.mit.edu	37	8	144590044	144590044	+	Silent	SNP	A	A	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:144590044A>G	ENST00000262577.5	-	4	1618	c.1587T>C	c.(1585-1587)acT>acC	p.T529T		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	529					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			TGGTGGGTGCAGTCCGCACGG	0.647000													12	111					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55587224	55587224	+	Silent	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr10:55587224C>T	ENST00000373965.2	-	33	4711	c.4317G>A	c.(4315-4317)gtG>gtA	p.V1439V	PCDH15_ENST00000361849.3_Silent_p.V1432V|PCDH15_ENST00000437009.1_Silent_p.V1361V|PCDH15_ENST00000409834.1_Silent_p.V1043V|PCDH15_ENST00000395438.1_Silent_p.V1432V|PCDH15_ENST00000320301.6_Silent_p.V1432V|PCDH15_ENST00000395430.1_Silent_p.V1429V|PCDH15_ENST00000395445.1_Silent_p.V1439V|PCDH15_ENST00000395432.2_Silent_p.V1392V|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000414778.1_Silent_p.V1434V|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000395433.1_Silent_p.V1407V|PCDH15_ENST00000395446.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395442.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1432	Poly-Pro.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				ggggcgCTGCCACTGGTGCAG	0.577000										HNSCC(58;0.16)			12	75					0	0	1	0	0
SYNRG	11276	broad.mit.edu	37	17	35902488	35902488	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:35902488C>A	ENST00000339208.6	-	15	2928	c.2788G>T	c.(2788-2790)Gag>Tag	p.E930*	SYNRG_ENST00000585472.1_Nonsense_Mutation_p.E851*|SYNRG_ENST00000502449.2_Nonsense_Mutation_p.E807*|SYNRG_ENST00000394378.2_Nonsense_Mutation_p.E852*|SYNRG_ENST00000591288.1_Nonsense_Mutation_p.E724*|SYNRG_ENST00000346661.4_Nonsense_Mutation_p.E930*|SYNRG_ENST00000345615.4_Nonsense_Mutation_p.E852*	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	930					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						AATGAAGTCTCTTTCTTTTGA	0.473000													31	139					1.06801e-11	1.5292e-11	1	1	0
OR2G2	81470	broad.mit.edu	37	1	247752389	247752389	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:247752389C>G	ENST00000320065.1	+	1	728	c.728C>G	c.(727-729)aCc>aGc	p.T243S	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCATTCGGGACCTGCTTCTCC	0.502000													31	137					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128148	83128148	+	Silent	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:83128148C>G	ENST00000329312.4	+	4	469	c.432C>G	c.(430-432)tcC>tcG	p.S144S		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	144					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						ATCCAGAATCCAAGCAAATAG	0.323000													7	42					0	0	1	0	0
LIN28A	79727	broad.mit.edu	37	1	26751830	26751830	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:26751830G>A	ENST00000326279.6	+	3	379	c.265G>A	c.(265-267)Gag>Aag	p.E89K	LIN28A_ENST00000254231.4_Missense_Mutation_p.E89K	NM_024674.4	NP_078950.1	Q9H9Z2	LN28A_HUMAN	lin-28 homolog A (C. elegans)	89	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)	8						GAGCTTGAAGGAGGGTGAGGC	0.458000													24	106					0	0	1	0	0
DGKB	1607	broad.mit.edu	37	7	14613853	14613853	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:14613853T>A	ENST00000403951.2	-	20	2176	c.1757A>T	c.(1756-1758)tAc>tTc	p.Y586F	DGKB_ENST00000444700.2_Missense_Mutation_p.Y567F|DGKB_ENST00000402815.1_Missense_Mutation_p.Y585F|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000407950.1_Missense_Mutation_p.Y578F|DGKB_ENST00000406247.3_Missense_Mutation_p.Y586F|DGKB_ENST00000399322.3_Missense_Mutation_p.Y586F|DGKB_ENST00000258767.5_Missense_Mutation_p.Y586F			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	586					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	AATGGAAAAGTAATTATTGAT	0.353000													24	265					0	0	1	0	0
FAM212A	389119	broad.mit.edu	37	3	49841819	49841819	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:49841819G>C	ENST00000333323.4	+	2	396	c.263G>C	c.(262-264)aGg>aCg	p.R88T		NM_203370.1	NP_976248.1	Q96EL1	CC054_HUMAN	family with sequence similarity 212, member A	86																	GGAGGCCCCAGGGAGCATGCC	0.617000													7	71					0	0	1	0	0
FAM110B	90362	broad.mit.edu	37	8	59059606	59059606	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr8:59059606G>T	ENST00000361488.3	+	5	1697	c.817G>T	c.(817-819)Gac>Tac	p.D273Y	FAM110B_ENST00000520369.1_Intron	NM_147189.2	NP_671722.1	Q8TC76	F110B_HUMAN	family with sequence similarity 110, member B	273						microtubule organizing center|mitochondrion|nucleus				breast(1)|endometrium(3)|kidney(1)|large_intestine(10)|lung(9)|skin(2)	26		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				AGTGGACGCGGACGTGGAGAG	0.532000													12	127					6.40141e-05	7.40951e-05	1	1	0
SLC5A12	159963	broad.mit.edu	37	11	26700322	26700322	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:26700322A>T	ENST00000396005.3	-	13	1825	c.1516T>A	c.(1516-1518)Tac>Aac	p.Y506N		NM_178498.3	NP_848593.2	Q1EHB4	SC5AC_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12	506					sodium ion transport	apical plasma membrane|integral to membrane	symporter activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)	35						GCACTGTAGTAAAGGTAGGAG	0.453000													14	91					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1271091	1271091	+	Silent	SNP	C	C	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:1271091C>G	ENST00000447027.1	+	31	13048	c.12990C>G	c.(12988-12990)ccC>ccG	p.P4330P	MUC5B_ENST00000529681.1_Silent_p.P4327P			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4327	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CACCCATCCCCTCCTCCACCC	0.617000													59	109					0	0	1	0	0
ERI3	79033	broad.mit.edu	37	1	44804865	44804865	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:44804865T>G	ENST00000372257.2	-	3	522	c.341A>C	c.(340-342)gAg>gCg	p.E114A	ERI3_ENST00000495828.1_5'UTR|ERI3_ENST00000537474.1_Intron	NM_024066.1	NP_076971.1	O43414	ERI3_HUMAN	ERI1 exoribonuclease family member 3	114						intracellular	exonuclease activity|metal ion binding|nucleic acid binding			endometrium(2)|large_intestine(2)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						GGAGCAGAACTCCGGAACACC	0.512000													35	251					0	0	1	0	0
LYST	1130	broad.mit.edu	37	1	235826359	235826359	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:235826359C>A	ENST00000389794.3	-	53	11461	c.11287G>T	c.(11287-11289)Ggc>Tgc	p.G3763C	LYST_ENST00000389793.2_Missense_Mutation_p.G3763C|LYST_ENST00000473037.1_5'UTR			Q99698	LYST_HUMAN	lysosomal trafficking regulator	3763					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAATGGTGGCCATCACAAGAA	0.393000													21	140					9.95505e-16	1.62599e-15	1	1	0
PYGO2	90780	broad.mit.edu	37	1	154931835	154931835	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:154931835C>A	ENST00000368457.2	-	3	812	c.641G>T	c.(640-642)cGa>cTa	p.R214L	PYGO2_ENST00000368456.1_Missense_Mutation_p.R177L	NM_138300.3	NP_612157.1	Q9BRQ0	PYGO2_HUMAN	pygopus family PHD finger 2	214	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			endometrium(2)|large_intestine(2)|lung(3)|skin(2)|urinary_tract(1)	10	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			CTGAGCAAATCGTTGGGACAG	0.627000													8	74					0.000274275	0.00030856	1	1	0
SLC34A1	6569	broad.mit.edu	37	5	176812786	176812786	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:176812786C>T	ENST00000324417.5	+	2	135	c.44C>T	c.(43-45)cCa>cTa	p.P15L	SLC34A1_ENST00000512593.1_Missense_Mutation_p.P15L	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	15					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCTGTCTCCCCACTCCCAGTC	0.632000													4	14					0	0	1	0	0
SLC30A6	55676	broad.mit.edu	37	2	32445541	32445541	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:32445541G>T	ENST00000282587.5	+	14	1182	c.1145G>T	c.(1144-1146)aGt>aTt	p.S382I	SLC30A6_ENST00000435660.1_Missense_Mutation_p.S359I|SLC30A6_ENST00000357055.3_Missense_Mutation_p.S185I|SLC30A6_ENST00000406369.1_Missense_Mutation_p.S308I|SLC30A6_ENST00000379343.2_Missense_Mutation_p.S422I|SLC30A6_ENST00000538303.1_Missense_Mutation_p.S353I	NM_017964.3	NP_060434.2	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter), member 6	382						Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(4)|lung(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					AAACCTAGTAGTCCACCTCCA	0.383000													27	142					6.32553e-13	9.55328e-13	1	1	0
PGD	5226	broad.mit.edu	37	1	10460608	10460608	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:10460608G>T	ENST00000538557.1	+	3	448	c.204G>T	c.(202-204)gtG>gtT	p.V68V	PGD_ENST00000541529.1_Silent_p.V81V|PGD_ENST00000270776.8_Silent_p.V81V			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	81					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		GGCAAGCTGTGGATGATTTCA	0.517000													11	50					1.33987e-11	1.91224e-11	1	1	0
HGF	3082	broad.mit.edu	37	7	81335720	81335720	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:81335720C>A	ENST00000222390.5	-	15	1866	c.1640G>T	c.(1639-1641)tGg>tTg	p.W547L	HGF_ENST00000457544.2_Missense_Mutation_p.W542L	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	547	Peptidase S1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						AATTCCAAGCCAAGCTTCATA	0.348000													18	102					2.94398e-08	3.82978e-08	1	1	0
DPH1	1801	broad.mit.edu	37	17	1943820	1943820	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr17:1943820G>T	ENST00000263083.6	+	9	988	c.943G>T	c.(943-945)Gcc>Tcc	p.A315S	DPH1_ENST00000570477.1_Missense_Mutation_p.A235S	NM_001383.3	NP_001374.3	Q9BZG8	DPH1_HUMAN	diphthamide biosynthesis 1	315					peptidyl-diphthamide biosynthetic process from peptidyl-histidine|translation	cytoplasm|nucleus				endometrium(3)|large_intestine(2)|lung(6)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	17						TCGACTCCGAGCCTTGGGCCT	0.572000													20	64					1.56442e-22	2.77072e-22	1	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299905	125299905	+	Translation_Start_Site	SNP	C	C	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:125299905C>A	ENST00000538699.1	-	2	83	c.3G>T	c.(1-3)atG>atT	p.M1I	DCAF12L2_ENST00000360028.2_Start_Codon_SNP_p.M1I	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	1										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						GCTGCTGGGCCATGGTGGGCG	0.776000													10	25					0.00621372	0.00665109	1	1	0
FLG2	388698	broad.mit.edu	37	1	152324100	152324100	+	Silent	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:152324100G>T	ENST00000388718.5	-	3	6234	c.6162C>A	c.(6160-6162)gcC>gcA	p.A2054A	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	2054							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTTGAGATCCGGCTTGGCCAT	0.527000													170	776					3.3515e-75	6.59826e-75	1	1	0
ARHGAP20	57569	broad.mit.edu	37	11	110450311	110450311	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:110450311C>T	ENST00000260283.4	-	16	3643	c.3359G>A	c.(3358-3360)aGa>aAa	p.R1120K	ARHGAP20_ENST00000524756.1_Missense_Mutation_p.R1097K|ARHGAP20_ENST00000528829.1_Missense_Mutation_p.R1084K|ARHGAP20_ENST00000529591.1_Missense_Mutation_p.R663K|ARHGAP20_ENST00000357139.3_Missense_Mutation_p.R1094K|ARHGAP20_ENST00000527598.1_Missense_Mutation_p.R1084K|ARHGAP20_ENST00000533353.1_Missense_Mutation_p.R1094K	NM_020809.3	NP_065860.2	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	1120					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(18)|lung(13)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	60		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GCTACAGTGTCTCTCTGAGTC	0.507000													28	82					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr22:18844763T>C	ENST00000412938.1	+	0	3013																											TCACAGCCTCTGAGGGCAGCA	0.562000													4	17					0	0	1	0	0
CFB	629	broad.mit.edu	37	6	31910804	31910804	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr6:31910804A>C	ENST00000456570.1	+	7	884	c.829A>C	c.(829-831)Aag>Cag	p.K277Q	CFB_ENST00000477310.1_Intron|C2_ENST00000469372.1_Missense_Mutation_p.K184Q|C2_ENST00000452323.2_Missense_Mutation_p.K216Q|C2_ENST00000299367.5_Missense_Mutation_p.K430Q|C2_ENST00000442278.2_Missense_Mutation_p.K298Q|CFB_ENST00000556679.1_Missense_Mutation_p.K277Q			P00751	CFAB_HUMAN	complement factor B	446	VWFA.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						AGGGTCCAAGAAGGATGGTGA	0.537000													10	275					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218976	130218976	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:130218976T>C	ENST00000276211.5	+	7	1238	c.893T>C	c.(892-894)tTc>tCc	p.F298S	ARHGAP36_ENST00000370922.1_Missense_Mutation_p.F286S|ARHGAP36_ENST00000370921.1_Missense_Mutation_p.F162S	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	298	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						AAGGAGTTTTTCCGTGACATG	0.473000													40	150					0	0	1	0	0
ZGPAT	84619	broad.mit.edu	37	20	62366093	62366093	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr20:62366093G>T	ENST00000328969.5	+	5	1095	c.968G>T	c.(967-969)aGc>aTc	p.S323I	ZGPAT_ENST00000490623.1_3'UTR|ZGPAT_ENST00000355969.6_Missense_Mutation_p.S303I|ZGPAT_ENST00000369967.3_Missense_Mutation_p.S303I|ZGPAT_ENST00000357119.4_Missense_Mutation_p.S294I|ZGPAT_ENST00000448100.1_Missense_Mutation_p.S303I	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	323					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					GGGACCTGCAGCTCTGCCTTT	0.612000													22	89					2.21704e-12	3.30308e-12	1	1	0
HTR3C	170572	broad.mit.edu	37	3	183776358	183776358	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:183776358G>C	ENST00000318351.1	+	6	737	c.703G>C	c.(703-705)Gac>Cac	p.D235H		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	235						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CAACCTATATGACCAGATCAT	0.512000													20	74					0	0	1	0	0
PHB2	11331	broad.mit.edu	37	12	7079658	7079658	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr12:7079658G>A	ENST00000535923.1	-	1	330	c.49C>T	c.(49-51)Cgg>Tgg	p.R17W	PHB2_ENST00000440277.1_Missense_Mutation_p.R17W|PHB2_ENST00000399433.2_Missense_Mutation_p.R17W|PHB2_ENST00000542912.1_Missense_Mutation_p.R17W|PHB2_ENST00000544134.1_5'UTR|PHB2_ENST00000546111.1_Missense_Mutation_p.R17W	NM_001144831.1	NP_001138303.1	Q99623	PHB2_HUMAN	prohibitin 2	17					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial inner membrane|nucleus	estrogen receptor binding|receptor activity			ovary(2)|pancreas(1)	3						CCCATGCCCCGGGGCCCGGCG	0.706000													4	19					0	0	1	0	0
NAALADL2	254827	broad.mit.edu	37	3	175473137	175473137	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr3:175473137T>A	ENST00000454872.1	+	13	2248	c.2120T>A	c.(2119-2121)aTg>aAg	p.M707K		NM_207015.2	NP_996898.2	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 2	707					proteolysis	integral to membrane	peptidase activity			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(20)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	49	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		CGCATCCGGATGCTGAATGAC	0.473000													9	28					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5727349	5727349	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr19:5727349A>T	ENST00000381624.3	+	3	258	c.197A>T	c.(196-198)tAt>tTt	p.Y66F	CATSPERD_ENST00000381614.2_5'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	66						integral to membrane											ATAGCACTATATCTAGGGTAA	0.338000													6	66					0	0	1	0	0
FAM132A	388581	broad.mit.edu	37	1	1179636	1179636	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:1179636delG	ENST00000330388.2	-	3	345	c.314delC	c.(313-315)cafs	p.P105fs		NM_001014980.2	NP_001014980.1	Q5T7M4	F132A_HUMAN	family with sequence similarity 132, member A	105						extracellular region				haematopoietic_and_lymphoid_tissue(1)|lung(1)	2	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;2.83e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.22e-21)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGGAGGTCCTGGGGGACCGAA	0.657													12	63	---	---	---	---					
TNR	7143	broad.mit.edu	37	1	175293627	175293628	+	Frame_Shift_Ins	INS	-	-	C			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:175293627_175293628insC	ENST00000367674.1	-	22	4529_4530	c.3821_3822insG	c.(3820-3822)cccfs	p.P1274fs	TNR_ENST00000263525.2_Frame_Shift_Ins_p.P1274fs|RP3-518E13.2_ENST00000569593.1_RNA	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1274	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix		p.R1274L(1)		NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TGGAGAAAGGGCGTCCTTGATG	0.480													12	182	---	---	---	---					
HMCN1	83872	broad.mit.edu	37	1	186099742	186099743	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr1:186099742_186099743delCC	ENST00000271588.4	+	85	13372_13373	c.13143_13144delCC	c.(13141-13146)atagfs	p.IQ4381fs	HMCN1_ENST00000367492.2_Frame_Shift_Del_p.IQ4381fs	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4381	Ig-like C2-type 43.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CCCCAACCATCCAGTGGAACAG	0.495													25	127	---	---	---	---					
AQP12B	653437	broad.mit.edu	37	2	241621800	241621800	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr2:241621800delC	ENST00000407834.3	-	1	517	c.455delG	c.(454-456)acfs	p.S153fs		NM_001102467.1	NP_001095937.1	A6NM10	AQ12B_HUMAN	aquaporin 12B	141						integral to membrane	transporter activity	p.S152fs*24(2)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|lung(8)|ovary(1)	13		all_epithelial(40;1.71e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.2e-31)|all cancers(36;1.08e-28)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.52e-06)|Lung(119;0.00163)|LUSC - Lung squamous cell carcinoma(224;0.008)|Colorectal(34;0.0124)|COAD - Colon adenocarcinoma(134;0.0757)		CAGGGCCGAGCTGCAGCTCTG	0.697													4	6	---	---	---	---					
CTC-338M12.9	0	broad.mit.edu	37	5	180708776	180708777	+	RNA	INS	-	-	G	rs140221514		TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr5:180708776_180708777insG	ENST00000412295.2	+	0	238																											gggcggtaggagggggctggag	0.728													2	4	---	---	---	---					
GLI3	2737	broad.mit.edu	37	7	42005301	42005301	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr7:42005301delG	ENST00000395925.3	-	15	3454	c.3370delC	c.(3370-3372)acfs	p.H1124fs	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	1124					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						CCGGGCCCGTGGGGCACTTTG	0.647									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				15	175	---	---	---	---					
MAMDC2	256691	broad.mit.edu	37	9	72723375	72723376	+	Frame_Shift_Ins	INS	-	-	A			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr9:72723375_72723376insA	ENST00000377182.4	+	3	1014_1015	c.397_398insA	c.(397-399)aaafs	p.K133fs	MAMDC2-AS1_ENST00000591368.1_RNA|MAMDC2-AS1_ENST00000414515.3_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	133	MAM 1.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						CTTGGATTTGCAAAACAGTTCC	0.386													21	69	---	---	---	---					
MUC5B	727897	broad.mit.edu	37	11	1263910	1263910	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:1263910delC	ENST00000447027.1	+	31	5867	c.5809delC	c.(5809-5811)ccfs	p.P1939fs	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Frame_Shift_Del_p.P1936fs			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1936	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			PPPKVLT -> GTPHVS (in Ref. 4; CAA96577).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GAGAACAGCTCCCCCTCCCAA	0.642													36	125	---	---	---	---					
C11orf16	56673	broad.mit.edu	37	11	8943062	8943062	+	Splice_Site	DEL	C	C	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:8943062delC	ENST00000326053.5	-	6	1311	c.1204_splice	c.e6-1	p.G402_splice	C11orf16_ENST00000525780.1_Intron	NM_020643.2	NP_065694.2	Q9NQ32	CK016_HUMAN	chromosome 11 open reading frame 16	402										central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	22				Epithelial(150;4.11e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0234)		ATATCTTGTTCCTAAACCCAA	0.408													25	102	---	---	---	---					
ARFGAP2	84364	broad.mit.edu	37	11	47196566	47196566	+	Splice_Site	DEL	T	T	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:47196566delT	ENST00000524782.1	-	5	708	c.480_splice	c.e5+1	p.Q160_splice	ARFGAP2_ENST00000395449.3_5'UTR|ARFGAP2_ENST00000319543.6_Intron|ARFGAP2_ENST00000419701.2_Intron|ARFGAP2_ENST00000426335.2_Intron	NM_001242832.1|NM_032389.4	NP_001229761.1|NP_115765.2	Q8N6H7	ARFG2_HUMAN	ADP-ribosylation factor GTPase activating protein 2	160	Required for interaction with coatomer.				protein transport|regulation of ARF GTPase activity|vesicle-mediated transport	Golgi membrane|nucleolus|plasma membrane	ARF GTPase activator activity|zinc ion binding			breast(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23						GGGCACTCACTTGAGTGTGTT	0.458													72	368	---	---	---	---					
OR8J3	81168	broad.mit.edu	37	11	55904527	55904527	+	Frame_Shift_Del	DEL	A	A	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr11:55904527delA	ENST00000301529.1	-	1	667	c.668delT	c.(667-669)tgfs	p.L223fs		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					TAGAATGGACAAAACAATATT	0.363													14	96	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20134648	20134648	+	RNA	DEL	A	A	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr14:20134648delA	ENST00000548261.1	+	0	391																											CTAACCACGTAAAAGGTAGTC	0.413													15	121	---	---	---	---					
ADAMTSL3	57188	broad.mit.edu	37	15	84611516	84611517	+	Frame_Shift_Ins	INS	-	-	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:84611516_84611517insT	ENST00000286744.5	+	18	2510_2511	c.2286_2287insT	c.(2284-2289)ggggcafs	p.A763fs	ADAMTSL3_ENST00000567476.1_Frame_Shift_Ins_p.A763fs	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	763	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding	p.G762G(1)		NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GCCCTCCTGGCTGGCACATTGA	0.574													13	27	---	---	---	---					
UBE2Q2P1	388165	broad.mit.edu	37	15	85077360	85077360	+	RNA	DEL	A	A	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr15:85077360delA	ENST00000339094.1	-	0	1678					NR_003661.2																						tttttaaactaaaaaaaaaaa	0.373													6	9	---	---	---	---					
CDH16	1014	broad.mit.edu	37	16	66950107	66950108	+	Splice_Site	INS	-	-	T			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chr16:66950107_66950108insT	ENST00000299752.4	-	5	479		c.e5-1		CDH16_ENST00000568632.1_Splice_Site|CDH16_ENST00000394055.3_Splice_Site|CDH16_ENST00000565796.1_Splice_Site|CDH16_ENST00000570262.1_Splice_Site	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		CCAGGGTGACCTGGCAGGGAAG	0.594													43	86	---	---	---	---					
HUWE1	10075	broad.mit.edu	37	X	53560323	53560323	+	Frame_Shift_Del	DEL	G	G	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:53560323delG	ENST00000342160.3	-	83	13529	c.13072delC	c.(13072-13074)acfs	p.H4358fs	HUWE1_ENST00000262854.6_Frame_Shift_Del_p.H4358fs			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	4358	HECT.				base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						AGTAGCATGTGGCGGAGCTTC	0.483													7	43	---	---	---	---					
PHF8	23133	broad.mit.edu	37	X	54037583	54037583	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8510-01A-11D-2393-08	TCGA-55-8510-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	109a0b2a-16a2-49ba-bf67-b82185691b44	fdfa1e8d-baa2-4e31-9bdf-64dbeacc7e5d	g.chrX:54037583delC	ENST00000338154.6	-	8	1422	c.918delG	c.(916-918)aafs	p.K306fs	PHF8_ENST00000338946.6_Frame_Shift_Del_p.K306fs|PHF8_ENST00000322659.8_Frame_Shift_Del_p.K306fs|PHF8_ENST00000357988.5_Frame_Shift_Del_p.K342fs	NM_015107.2	NP_055922.1	Q9UPP1	PHF8_HUMAN	PHD finger protein 8	342	JmjC.				brain development|G1/S transition of mitotic cell cycle|negative regulation of chromatin silencing at rDNA|positive regulation of transcription from RNA polymerase I promoter|transcription, DNA-dependent	nucleolus	chromatin binding|histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(10)|ovary(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	40						TCTGTCCTTGCTTCACGGAAC	0.512													11	100	---	---	---	---					
