Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FLCN	201163	broad.mit.edu	37	17	17124800	17124800	+	Missense_Mutation	SNP	C	C	A	rs148567904		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:17124800C>A	ENST00000389169.5	-	8	1376	c.922G>T	c.(922-924)Ggt>Tgt	p.G308C	FLCN_ENST00000285071.4_Intron|RP11-45M22.4_ENST00000427497.3_Intron	NM_144606.5	NP_653207.1	Q8NFG4	FLCN_HUMAN	folliculin	0					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|stomach(1)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						CAGCTGGTACCGCCCCACGGC	0.647000									Familial Non-VHL Clear Cell Renal Cancer;Birt-Hogg-Dub syndrome				35	65					3.33393e-15	4.04412e-15	1	1	0
TBC1D32	221322	broad.mit.edu	37	6	121452773	121452773	+	Splice_Site	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:121452773C>A	ENST00000275159.6	-	26	3021	c.3022_splice	c.e26+1	p.A1008_splice	TBC1D32_ENST00000398212.2_Splice_Site_p.A967_splice|TBC1D32_ENST00000398197.2_5'UTR					TBC1 domain family, member 32																		ATGTACTTACCCTCTCCACTG	0.308000													14	15					4.93089e-13	5.77619e-13	1	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18684735	18684735	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr9:18684735A>C	ENST00000380548.4	+	13	1850	c.1511A>C	c.(1510-1512)aAg>aCg	p.K504T	ADAMTSL1_ENST00000327883.7_Missense_Mutation_p.K504T|ADAMTSL1_ENST00000276935.6_Missense_Mutation_p.K504T	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	504						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GTCGAGGCCAAGTTGCCATGG	0.423000													3	23					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73843264	73843264	+	Silent	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:73843264C>A	ENST00000342056.2	+	11	1823	c.1425C>A	c.(1423-1425)ggC>ggA	p.G475G	KCNQ5_ENST00000402622.2_Silent_p.G466G|KCNQ5_ENST00000414165.2_Intron|KCNQ5_ENST00000355194.4_Silent_p.G456G|KCNQ5_ENST00000403813.2_Silent_p.G447G|KCNQ5_ENST00000355635.3_Silent_p.G457G|KCNQ5_ENST00000370398.1_Silent_p.G456G	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	456					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CAGCCGAGGGCAGTCCCACCA	0.592000													10	81					6.40141e-05	6.76438e-05	1	1	0
NFATC2	4773	broad.mit.edu	37	20	50090662	50090662	+	Silent	SNP	A	A	C	rs148245628		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr20:50090662A>C	ENST00000371564.3	-	5	1782	c.1563T>G	c.(1561-1563)ctT>ctG	p.L521L	NFATC2_ENST00000396009.3_Silent_p.L521L|NFATC2_ENST00000414705.1_Silent_p.L501L	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	521	RHD.				B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					CGGCGTTTCTAAGCTTCAAGA	0.532000													26	82					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762771	130762771	+	Silent	SNP	C	C	A	rs146211569		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:130762771C>A	ENST00000392429.1	+	2	3582	c.1204C>A	c.(1204-1206)Cgg>Agg	p.R402R	TMEM200A_ENST00000296978.3_Silent_p.R402R|TMEM200A_ENST00000545622.1_Silent_p.R402R	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	402						integral to membrane		p.R402G(2)		NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		GGACTTAGACCGGGGTCCCTC	0.502000													37	55					4.11147e-13	4.84398e-13	1	1	0
OR4N5	390437	broad.mit.edu	37	14	20612771	20612771	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr14:20612771G>T	ENST00000333629.1	+	1	877	c.877G>T	c.(877-879)Gag>Tag	p.E293*		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TCGCAACCAGGAGGTGAAAGC	0.413000													57	123					3.31993e-32	4.53723e-32	1	1	0
TCF7L1	83439	broad.mit.edu	37	2	85529723	85529723	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:85529723G>C	ENST00000282111.3	+	5	917	c.642G>C	c.(640-642)gaG>gaC	p.E214D		NM_031283.2	NP_112573.1	Q9HCS4	TF7L1_HUMAN	transcription factor 7-like 1 (T-cell specific, HMG-box)	214	Pro-rich.				chromatin organization|regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|skin(4)|upper_aerodigestive_tract(1)	18						TCTCCCCAGAGATCGATCCAA	0.587000													547	130					0	0	1	0	0
PREX1	57580	broad.mit.edu	37	20	47266679	47266679	+	Silent	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr20:47266679C>A	ENST00000396220.1	-	24	2905	c.2883G>T	c.(2881-2883)ccG>ccT	p.P961P	PREX1_ENST00000371941.3_Silent_p.P961P			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	961					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGCCACACAGCGGGTGGGGCT	0.592000													19	87					4.96729e-08	5.44542e-08	1	1	0
SPOCK3	50859	broad.mit.edu	37	4	167656097	167656097	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr4:167656097C>T	ENST00000357154.3	-	12	1423	c.1286G>A	c.(1285-1287)gGt>gAt	p.G429D	SPOCK3_ENST00000421836.2_Missense_Mutation_p.G378D|SPOCK3_ENST00000541637.1_Missense_Mutation_p.G331D|SPOCK3_ENST00000541354.1_Missense_Mutation_p.G309D|SPOCK3_ENST00000502330.1_Missense_Mutation_p.G429D|SPOCK3_ENST00000534949.1_Missense_Mutation_p.G333D|SPOCK3_ENST00000511269.1_Missense_Mutation_p.G426D|SPOCK3_ENST00000357545.4_Missense_Mutation_p.G426D|SPOCK3_ENST00000512681.1_Missense_Mutation_p.G331D|SPOCK3_ENST00000510741.1_Missense_Mutation_p.G386D|SPOCK3_ENST00000506886.1_Missense_Mutation_p.G429D|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000511531.1_Missense_Mutation_p.G429D|SPOCK3_ENST00000504953.1_Missense_Mutation_p.G426D|SPOCK3_ENST00000535728.1_Missense_Mutation_p.G297D	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	429	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		atggtcatcaccaccatcatc	0.308000													6	47					0	0	1	0	0
NRIP2	83714	broad.mit.edu	37	12	2937101	2937101	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:2937101G>T	ENST00000337508.4	-	4	731	c.691C>A	c.(691-693)Cag>Aag	p.Q231K	ITFG2_ENST00000542548.1_Intron	NM_031474.2	NP_113662.1	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	231					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CCCACCACCTGTGCCGAGCAC	0.627000													24	79					2.21704e-12	2.58234e-12	1	1	0
KRTAP19-7	337974	broad.mit.edu	37	21	31933439	31933439	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr21:31933439T>A	ENST00000334849.2	-	1	194	c.170A>T	c.(169-171)tAc>tTc	p.Y57F		NM_181614.1	NP_853645.1	Q3SYF9	KR197_HUMAN	keratin associated protein 19-7	57						intermediate filament				endometrium(1)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	11						AGAAGACCAGTATCCCCCATA	0.448000													27	134					0	0	1	0	0
ATP6V0C	527	broad.mit.edu	37	16	2569669	2569669	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr16:2569669A>G	ENST00000330398.4	+	3	625	c.391A>G	c.(391-393)Atg>Gtg	p.M131V	ATP6V0C_ENST00000565223.1_Missense_Mutation_p.M88V|ATP6V0C_ENST00000564973.1_Missense_Mutation_p.M88V|ATP6V0C_ENST00000568562.1_3'UTR|RP11-20I23.1_ENST00000564543.1_3'UTR|ATP6C_ENST00000569317.1_Intron	NM_001198569.1|NM_001694.3	NP_001185498.1|NP_001685.1	P27449	VATL_HUMAN	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	131					ATP hydrolysis coupled proton transport|ATP synthesis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|interspecies interaction between organisms|transferrin transport	endosome membrane|integral to membrane|proton-transporting ATP synthase complex, coupling factor F(o)|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism|ubiquitin protein ligase binding			endometrium(1)|lung(1)|ovary(1)	3		Ovarian(90;0.17)				ATTCGTGGGCATGATCCTGAT	0.662000													12	79					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40126142	40126142	+	Splice_Site	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr20:40126142C>T	ENST00000373233.3	-	8	1152		c.e8-1		CHD6_ENST00000309279.7_Splice_Site|CHD6_ENST00000373222.3_3'UTR	NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6						chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TAAGTAGGAACTATCCAAAGA	0.413000													33	107					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394277	154394277	+	Silent	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:154394277G>T	ENST00000435029.4	+	1	1018	c.858G>T	c.(856-858)gtG>gtT	p.V286V		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	286	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTAGCTTTGTGCCCTACAGAG	0.453000													71	147					5.00936e-31	6.6683e-31	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141747214	141747214	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:141747214C>G	ENST00000389484.3	-	17	3628	c.2657G>C	c.(2656-2658)tGt>tCt	p.C886S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	886	LDL-receptor class A 4.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATCATCAGGACAGCTATGATT	0.378000										TSP Lung(27;0.18)			26	97					0	0	1	0	0
ZNF804B	219578	broad.mit.edu	37	7	88962737	88962737	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr7:88962737G>T	ENST00000333190.4	+	4	1050	c.441G>T	c.(439-441)caG>caT	p.Q147H		NM_181646.2	NP_857597.1	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	147						intracellular	zinc ion binding			NS(1)|breast(2)|endometrium(5)|kidney(5)|large_intestine(20)|lung(78)|ovary(5)|pancreas(5)|prostate(2)|skin(11)|soft_tissue(1)|upper_aerodigestive_tract(9)	144	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			AGCAACTCCAGCAAGGAATTT	0.383000										HNSCC(36;0.09)			11	37					1.58986e-06	1.71538e-06	1	1	0
ASTN1	460	broad.mit.edu	37	1	177030277	177030277	+	Silent	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:177030277G>A	ENST00000367654.2	-	2	421	c.408C>T	c.(406-408)ccC>ccT	p.P136P	ASTN1_ENST00000367657.3_Silent_p.P136P|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000361833.2_Silent_p.P136P|ASTN1_ENST00000424564.2_Silent_p.P136P			O14525	ASTN1_HUMAN	astrotactin 1	136					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GTTCTTCAGTGGGGTCTTGTC	0.542000													55	295					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98515272	98515272	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr7:98515272C>A	ENST00000359863.4	+	20	2801	c.2592C>A	c.(2590-2592)caC>caA	p.H864Q	TRRAP_ENST00000446306.3_Missense_Mutation_p.H863Q|TRRAP_ENST00000355540.3_Missense_Mutation_p.H864Q	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	864					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			TCTACGACCACATCCAGCCGG	0.572000													19	36					1.33834e-09	1.49923e-09	1	1	0
MUC5B	727897	broad.mit.edu	37	11	1272612	1272612	+	Silent	SNP	C	C	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr11:1272612C>G	ENST00000447027.1	+	31	14569	c.14511C>G	c.(14509-14511)tcC>tcG	p.S4837S	MUC5B_ENST00000529681.1_Silent_p.S4834S			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4834	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACTGGATCCACGGCCACCC	0.647000													22	119					0	0	1	0	0
TMEM71	137835	broad.mit.edu	37	8	133740143	133740143	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr8:133740143T>A	ENST00000356838.3	-	6	662	c.520A>T	c.(520-522)Atc>Ttc	p.I174F	TMEM71_ENST00000377901.4_Intron|TMEM71_ENST00000523829.1_Missense_Mutation_p.I193F	NM_144649.2	NP_653250.2	Q6P5X7	TMM71_HUMAN	transmembrane protein 71	193						integral to membrane				endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGAGATATGATGTGGCTGGAA	0.468000													42	143					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175092699	175092699	+	Silent	SNP	T	T	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:175092699T>G	ENST00000239462.4	+	12	2927	c.2814T>G	c.(2812-2814)acT>acG	p.T938T		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	938	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		ACAGCAGCACTGTCCTGACGG	0.627000													38	88					0	0	1	0	0
FAM83D	81610	broad.mit.edu	37	20	37581025	37581025	+	Silent	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr20:37581025C>T	ENST00000217429.4	+	4	1751	c.1710C>T	c.(1708-1710)tcC>tcT	p.S570S		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	540					cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				GTATCAGGTCCCGGCTCAACC	0.488000													45	126					0	0	1	0	0
CDKN3	1033	broad.mit.edu	37	14	54884582	54884582	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr14:54884582A>G	ENST00000543789.2	+	6	523	c.433A>G	c.(433-435)Act>Gct	p.T145A	CDKN3_ENST00000458126.2_Silent_p.L154L|CDKN3_ENST00000395577.2_Silent_p.L109L|CDKN3_ENST00000556305.1_3'UTR|CDKN3_ENST00000556102.2_Silent_p.L155L|CDKN3_ENST00000335183.6_Silent_p.L155L|CDKN3_ENST00000442975.2_Silent_p.L115L			Q16667	CDKN3_HUMAN	cyclin-dependent kinase inhibitor 3	0					cell cycle arrest|G1/S transition of mitotic cell cycle|negative regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity	perinuclear region of cytoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(2)|stomach(1)	3						CTTGTCTCCTACTATACCTGT	0.413000													8	4					0	0	1	0	0
PIGS	94005	broad.mit.edu	37	17	26887088	26887088	+	Silent	SNP	G	G	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:26887088G>C	ENST00000308360.7	-	7	1173	c.798C>G	c.(796-798)ggC>ggG	p.G266G	PIGS_ENST00000543734.1_Silent_p.G205G|PIGS_ENST00000395346.2_Silent_p.G258G|PIGS_ENST00000465444.1_5'UTR	NM_033198.3	NP_149975.1	Q96S52	PIGS_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class S	266					attachment of GPI anchor to protein|C-terminal protein lipidation	GPI-anchor transamidase complex	protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(42;0.00431)					CAGAGAAGTTGCCAGCGGCAC	0.517000													46	54					0	0	1	0	0
FBL	2091	broad.mit.edu	37	19	40325327	40325327	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:40325327C>A	ENST00000221801.3	-	8	1035	c.922G>T	c.(922-924)Gtg>Ttg	p.V308L	FBL_ENST00000593503.1_5'UTR	NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	308					rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		CCCACGACCACGGCATGGTCT	0.567000													42	86					3.61848e-18	4.5231e-18	1	1	0
LGALS9	3965	broad.mit.edu	37	17	25970600	25970600	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:25970600C>T	ENST00000395473.2	+	5	1962	c.494C>T	c.(493-495)tCc>tTc	p.S165F	LGALS9_ENST00000302228.5_Intron|LGALS9_ENST00000413914.2_Missense_Mutation_p.S108F|LGALS9_ENST00000310394.5_Intron|LGALS9_ENST00000313648.6_Intron	NM_009587.2	NP_033665.1	O00182	LEG9_HUMAN	lectin, galactoside-binding, soluble, 9	165					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity			endometrium(3)|large_intestine(2)|lung(12)|skin(1)	18	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		GTGCCGTTCTCCCAGCCTGTC	0.582000													26	38					0	0	1	0	0
CCDC122	160857	broad.mit.edu	37	13	44442842	44442842	+	Silent	SNP	C	C	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr13:44442842C>G	ENST00000444614.3	-	4	402	c.144G>C	c.(142-144)ctG>ctC	p.L48L	CCDC122_ENST00000281508.3_Silent_p.L48L|CCDC122_ENST00000476570.2_5'UTR	NM_144974.3	NP_659411.2	Q5T0U0	CC122_HUMAN	coiled-coil domain containing 122	48								p.L48L(1)		endometrium(1)|large_intestine(2)|lung(5)|stomach(1)	9		Lung NSC(96;7.5e-06)|Breast(139;0.00765)|Hepatocellular(98;0.00826)|Prostate(109;0.0143)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000767)|BRCA - Breast invasive adenocarcinoma(63;0.128)		TCAAATTGAACAGAACCTTTT	0.303000													2	6					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	88					0	0	1	0	0
SLC11A2	4891	broad.mit.edu	37	12	51398615	51398615	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:51398615T>A	ENST00000394904.3	-	5	521	c.472A>T	c.(472-474)Act>Tct	p.T158S	SLC11A2_ENST00000547688.1_Missense_Mutation_p.T158S|SLC11A2_ENST00000541174.2_Missense_Mutation_p.T129S|SLC11A2_ENST00000547198.1_Missense_Mutation_p.T129S|SLC11A2_ENST00000262051.7_Missense_Mutation_p.T129S|SLC11A2_ENST00000546743.1_Missense_Mutation_p.T50S|SLC11A2_ENST00000262052.5_Missense_Mutation_p.T129S|SLC11A2_ENST00000545993.2_Missense_Mutation_p.T125S	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	129					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						TGCAGCCCAGTAACCACTCCC	0.507000													7	62					0	0	1	0	0
NEUROG1	4762	broad.mit.edu	37	5	134871293	134871293	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:134871293C>T	ENST00000314744.4	-	1	346	c.88G>A	c.(88-90)Gaa>Aaa	p.E30K		NM_006161.2	NP_006152.2	Q92886	NGN1_HUMAN	neurogenin 1	30					positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter	nucleus	chromatin binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			endometrium(1)|liver(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCACAGTCTTCCTCGTCGGTG	0.692000													7	6					0	0	1	0	0
MGA	23269	broad.mit.edu	37	15	41961656	41961656	+	Silent	SNP	A	A	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr15:41961656A>G	ENST00000219905.7	+	2	745	c.564A>G	c.(562-564)caA>caG	p.Q188Q	MGA_ENST00000389936.4_Silent_p.Q188Q|MGA_ENST00000568630.1_Intron|MGA_ENST00000545763.1_Silent_p.Q188Q|MGA_ENST00000570161.1_Silent_p.Q188Q|MGA_ENST00000566586.1_Silent_p.Q188Q	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	188						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		CACTGGACCAAGAAGGGCATA	0.438000													120	200					0	0	1	0	0
DCAF8L2	347442	broad.mit.edu	37	X	27766805	27766805	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chrX:27766805G>A	ENST00000451261.2	+	5	2192	c.1793G>A	c.(1792-1794)aGt>aAt	p.S598N		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						GACTGGAGAAGTGGTGAAGCT	0.532000													12	4					0	0	1	0	0
ACTL8	81569	broad.mit.edu	37	1	18152816	18152816	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:18152816C>A	ENST00000375406.1	+	3	1119	c.903C>A	c.(901-903)aaC>aaA	p.N301K		NM_030812.2	NP_110439.2	Q9H568	ACTL8_HUMAN	actin-like 8	301						cytoplasm|cytoskeleton				NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	28		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00186)|all_lung(284;0.0054)|Lung NSC(340;0.00566)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;6.43e-06)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.00652)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)		GCGGGGGCAACACCCTCTATC	0.632000											OREG0013157	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	38	55					1.49673e-21	1.92975e-21	1	1	0
OR2C3	81472	broad.mit.edu	37	1	247695263	247695263	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:247695263A>T	ENST00000366487.3	-	2	912	c.551T>A	c.(550-552)cTc>cAc	p.L184H	GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000463359.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TTGCATAATGAGGGGCATCTC	0.557000													28	51					0	0	1	0	0
C5orf42	65250	broad.mit.edu	37	5	37169397	37169397	+	Silent	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:37169397T>A	ENST00000274258.7	-	34	6956	c.3369A>T	c.(3367-3369)acA>acT	p.T1123T	C5orf42_ENST00000425232.2_Silent_p.T2243T|C5orf42_ENST00000508244.1_Silent_p.T2243T			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	2243										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GAATACTTCCTGTATGTAAGA	0.453000													31	196					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													5	36					0.184627	0.184627	1	1	0
ADAMTS16	170690	broad.mit.edu	37	5	5200294	5200294	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:5200294G>A	ENST00000274181.7	+	9	1501	c.1363G>A	c.(1363-1365)Ggc>Agc	p.G455S	ADAMTS16_ENST00000511368.1_Missense_Mutation_p.G455S	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	455	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						AAAGTCCGAGGGCAACATCAT	0.458000													23	71					0	0	1	0	0
C8orf58	541565	broad.mit.edu	37	8	22459488	22459488	+	Missense_Mutation	SNP	C	C	T	rs147403979	byFrequency	TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr8:22459488C>T	ENST00000409586.3	+	4	781	c.661C>T	c.(661-663)Ccc>Tcc	p.P221S	C8orf58_ENST00000289989.5_Missense_Mutation_p.P221S	NM_001013842.2|NM_001198827.1|NM_173686.2	NP_001013864.1|NP_001185756.1|NP_775957.2	Q8NAV2	CH058_HUMAN	chromosome 8 open reading frame 58	221										endometrium(1)|lung(1)|ovary(1)|skin(1)	4		Prostate(55;0.0421)|Breast(100;0.102)|all_epithelial(46;0.142)		BRCA - Breast invasive adenocarcinoma(99;0.00563)|Colorectal(74;0.0145)|COAD - Colon adenocarcinoma(73;0.0608)		TGCATAGGATCCCGGCGAGGA	0.637000													3	21					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78542632	78542632	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:78542632A>T	ENST00000397909.2	+	22	4891	c.4718A>T	c.(4717-4719)aAa>aTa	p.K1573I	NAV3_ENST00000266692.7_Missense_Mutation_p.K1396I|NAV3_ENST00000536525.2_Missense_Mutation_p.K1573I|NAV3_ENST00000228327.6_Missense_Mutation_p.K1573I			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1573						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CAAATCCATAAACTGCGGAGA	0.333000										HNSCC(70;0.22)			11	40					0	0	1	0	0
GLUD1	2746	broad.mit.edu	37	10	88854406	88854406	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr10:88854406G>T	ENST00000277865.4	-	1	217	c.121C>A	c.(121-123)Ccg>Acg	p.P41T		NM_005271.3	NP_005262.1	P00367	DHE3_HUMAN	glutamate dehydrogenase 1	41					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding			endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(11)|prostate(1)	22					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCCGGCTGCGGGGCGGCGGCG	0.756000													30	20					2.4375e-19	3.10365e-19	1	1	0
ERLEC1	27248	broad.mit.edu	37	2	54021509	54021509	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:54021509G>C	ENST00000185150.4	+	2	321	c.190G>C	c.(190-192)Gat>Cat	p.D64H	ASB3_ENST00000406625.2_Intron|ERLEC1_ENST00000494373.1_3'UTR|GPR75-ASB3_ENST00000352846.3_Intron|ASB3_ENST00000498475.2_Intron|ERLEC1_ENST00000405123.3_Missense_Mutation_p.D64H|ERLEC1_ENST00000378239.5_Missense_Mutation_p.D64H	NM_015701.4	NP_056516.2	Q96DZ1	ERLEC_HUMAN	endoplasmic reticulum lectin 1	64					ER-associated protein catabolic process	endoplasmic reticulum lumen	glycoprotein binding|protein binding			endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|stomach(1)|urinary_tract(1)	18						ATATAAAGAAGATAATTATGT	0.313000													6	92					0	0	1	0	0
WDR64	128025	broad.mit.edu	37	1	241886621	241886621	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:241886621G>T	ENST00000366552.2	+	9	1254	c.1047G>T	c.(1045-1047)ttG>ttT	p.L349F	WDR64_ENST00000437684.2_Missense_Mutation_p.L349F	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	349								p.L349F(1)|p.L69F(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TCATCCGGTTGTGGCACCCCA	0.443000													49	107					4.0181e-32	5.45504e-32	1	1	0
ZNF423	23090	broad.mit.edu	37	16	49670418	49670418	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr16:49670418G>A	ENST00000561648.1	-	4	2698	c.2645C>T	c.(2644-2646)tCg>tTg	p.S882L	ZNF423_ENST00000567169.1_Missense_Mutation_p.S765L|ZNF423_ENST00000562871.1_Missense_Mutation_p.S822L|ZNF423_ENST00000563137.2_Missense_Mutation_p.S822L|ZNF423_ENST00000535559.1_Missense_Mutation_p.S765L|ZNF423_ENST00000262383.2_Missense_Mutation_p.S882L|ZNF423_ENST00000562520.1_Missense_Mutation_p.S822L	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	882					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CATGGGCTCCGACGCGTCCAC	0.627000													5	84					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458777	248458777	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:248458777G>C	ENST00000317996.1	-	1	103	c.104C>G	c.(103-105)aCc>aGc	p.T35S		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			AAACAGGGAGGTCAAAACGGT	0.507000													47	229					0	0	1	0	0
KRT18P55	284085	broad.mit.edu	37	17	26604107	26604107	+	RNA	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:26604107C>A	ENST00000577198.1	-	0	854					NR_028334.1																						GTCGTTGAGGCTTTGCATGGT	0.602000													23	169					1.66031e-10	1.88046e-10	1	1	0
GLRA4	441509	broad.mit.edu	37	X	102974030	102974030	+	Silent	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chrX:102974030G>T	ENST00000372617.4	-	7	1308	c.888C>A	c.(886-888)ctC>ctA	p.L296L		NM_001024452.2	NP_001019623.2	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4	296						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						TGGTCATGGTGAGCACGGTGG	0.577000													63	58					1.75667e-42	2.44977e-42	1	1	0
NRSN1	140767	broad.mit.edu	37	6	24145932	24145932	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:24145932A>C	ENST00000378491.4	+	4	647	c.346A>C	c.(346-348)Aag>Cag	p.K116Q		NM_080723.4	NP_542454.3	Q8IZ57	NRSN1_HUMAN	neurensin 1	116					nervous system development	growth cone|integral to membrane|neuronal cell body|transport vesicle				breast(1)|endometrium(2)|large_intestine(2)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	22						GGACATGTACAAGCTGGCAGG	0.502000													17	119					0	0	1	0	0
TMCO4	255104	broad.mit.edu	37	1	20073003	20073003	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:20073003C>T	ENST00000294543.6	-	9	944	c.703G>A	c.(703-705)Gcc>Acc	p.A235T	TMCO4_ENST00000375122.2_Missense_Mutation_p.A235T|TMCO4_ENST00000375127.1_Missense_Mutation_p.A235T	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	235						integral to membrane				biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		GCTATGCCGGCTGCTGAGCCC	0.582000													6	15					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8539051	8539051	+	Splice_Site	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:8539051G>T	ENST00000348943.3	+	13	1158	c.925_splice	c.e13-1	p.G309_splice	HNRNPM_ENST00000325495.4_Splice_Site_p.G348_splice	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	348					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						TCTCTTGCAGGAATGGAGGGG	0.448000													43	126					2.35958e-20	3.02322e-20	1	1	0
CUL7	9820	broad.mit.edu	37	6	43014810	43014810	+	Silent	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:43014810C>A	ENST00000535468.1	-	10	2543	c.2457G>T	c.(2455-2457)ctG>ctT	p.L819L	CUL7_ENST00000265348.3_Silent_p.L735L|CUL7_ENST00000478630.1_5'UTR	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	735	DOC.				interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			TCACTGAGGTCAGGCGGTGCA	0.582000													69	94					2.69673e-31	3.61327e-31	1	1	0
PCSK4	54760	broad.mit.edu	37	19	1487981	1487981	+	Silent	SNP	C	C	T	rs151115553	byFrequency	TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:1487981C>T	ENST00000300954.5	-	4	559	c.498G>A	c.(496-498)ccG>ccA	p.P166P	PCSK4_ENST00000587784.1_5'UTR	NM_017573.3	NP_060043.2	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	166	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity			cervix(2)|endometrium(2)|kidney(1)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGAGGTCCGGGTGGTCCT	0.692000													7	125					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110534559	110534559	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr8:110534559G>T	ENST00000378402.5	+	74	12280	c.12176G>T	c.(12175-12177)tGg>tTg	p.W4059L		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	4059					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GACTCTGGGTGGATTAAGGTA	0.338000										HNSCC(38;0.096)			20	61					3.5997e-14	4.26554e-14	1	1	0
PLCB2	5330	broad.mit.edu	37	15	40587216	40587216	+	Silent	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr15:40587216G>T	ENST00000260402.3	-	18	2076	c.1827C>A	c.(1825-1827)cgC>cgA	p.R609R	PLCB2_ENST00000557821.1_Silent_p.R605R|PLCB2_ENST00000456256.2_Silent_p.R609R	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	609	PI-PLC Y-box.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		AGGAGTCCATGCGGGTTCCCT	0.567000													47	89					1.17673e-23	1.52677e-23	1	1	0
THUMPD2	80745	broad.mit.edu	37	2	39996966	39996966	+	Missense_Mutation	SNP	C	C	T	rs74719162		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:39996966C>T	ENST00000505747.1	-	3	583	c.556G>A	c.(556-558)Gaa>Aaa	p.E186K	THUMPD2_ENST00000454352.2_Missense_Mutation_p.E156K|THUMPD2_ENST00000403537.3_5'UTR|THUMPD2_ENST00000260619.6_Missense_Mutation_p.E156K	NM_025264.4	NP_079540.2	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	186	THUMP.						methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	17		all_hematologic(82;0.248)				AATTCTTCTTCTTGAAACTTT	0.358000													9	67					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156964947	156964947	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:156964947G>A	ENST00000257527.4	-	4	382	c.304C>T	c.(304-306)Cct>Tct	p.P102S	ADAM19_ENST00000517905.1_Missense_Mutation_p.P102S|ADAM19_ENST00000394020.1_Missense_Mutation_p.P104S|ADAM19_ENST00000430702.2_5'UTR	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	102					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGTTTGAGGGTTACCACTT	0.443000													24	59					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116616440	116616440	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr8:116616440T>A	ENST00000395715.3	-	4	2333	c.1756A>T	c.(1756-1758)Agc>Tgc	p.S586C	TRPS1_ENST00000220888.5_Missense_Mutation_p.S573C|TRPS1_ENST00000519076.1_Intron|TRPS1_ENST00000520276.1_Missense_Mutation_p.S577C|TRPS1_ENST00000519674.1_Missense_Mutation_p.S573C	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	573					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			TTTTCTGGGCTGCAAAGTCCT	0.448000									Langer-Giedion syndrome				78	49					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	87951855	87951855	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr8:87951855C>T	ENST00000518476.1	+	4	355	c.304C>T	c.(304-306)Cat>Tat	p.H102Y		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	102										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						GGAAAGTCAACATCAACAACC	0.343000													13	110					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263418	248263418	+	Silent	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:248263418G>A	ENST00000366478.2	+	3	1078	c.741G>A	c.(739-741)gtG>gtA	p.V247V	OR2L13_ENST00000358120.2_Silent_p.V247V	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TAACTGTAGTGATCTTTTACT	0.458000													30	172					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70926781	70926781	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:70926781T>G	ENST00000357250.6	-	38	2743	c.2585A>C	c.(2584-2586)gAc>gCc	p.D862A	COL9A1_ENST00000320755.7_Missense_Mutation_p.D619A|COL9A1_ENST00000370499.4_Missense_Mutation_p.D619A|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	862	Triple-helical region (COL1).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AGGGCCTGGGTCACCTGAAAC	0.587000													3	32					0	0	1	0	0
FAM86JP	100125556	broad.mit.edu	37	3	125647387	125647387	+	RNA	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr3:125647387G>A	ENST00000485843.1	+	0	532					NR_024251.1																						ACCAGAAACTGTTTCCCTATG	0.502000													7	143					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68784777	68784777	+	Missense_Mutation	SNP	C	C	T	rs139061539	byFrequency	TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr4:68784777C>T	ENST00000508048.1	-	8	898	c.863G>A	c.(862-864)cGc>cAc	p.R288H	TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.R289H|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.R292H			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	292	Peptidase S1.			S -> P (in Ref. 1; AAD41463).	cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						ACAAATCTGGCGTATGTCATC	0.463000													38	152					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073399	17073399	+	Silent	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr22:17073399C>A	ENST00000359963.3	-	1	301	c.42G>T	c.(40-42)cgG>cgT	p.R14R		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	14					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TCAGTGCCAGCCGCTGGGGCA	0.637000													24	54					4.7796e-09	5.26784e-09	1	1	0
PCDHA5	56143	broad.mit.edu	37	5	140201950	140201950	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:140201950A>T	ENST00000529859.1	+	1	590	c.590A>T	c.(589-591)aAa>aTa	p.K197I	PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.K197I|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.K197I|PCDHA1_ENST00000504120.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTTTGAGGAAATCCTTAGAT	0.343000													32	101					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1220640	1220640	+	Nonsense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:1220640C>T	ENST00000326873.7	+	5	1831	c.658C>T	c.(658-660)Cag>Tag	p.Q220*		NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	220	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.Q220*(4)|p.?(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCGGCTTTCCAGCCGCCCGA	0.711000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			21	7					0	0	1	0	0
RHBDF2	79651	broad.mit.edu	37	17	74475272	74475272	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:74475272C>T	ENST00000591885.1	-	5	910	c.360G>A	c.(358-360)atG>atA	p.M120I	RHBDF2_ENST00000389760.4_Missense_Mutation_p.M120I|RHBDF2_ENST00000592378.1_5'UTR|RHBDF2_ENST00000313080.4_Missense_Mutation_p.M149I			Q6PJF5	RHDF2_HUMAN	rhomboid 5 homolog 2 (Drosophila)	149					negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(4)|skin(1)	27						GGCCGTAGCGCATGCTGCAGT	0.692000													17	51					0	0	1	0	0
FBXO41	150726	broad.mit.edu	37	2	73491614	73491614	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:73491614C>T	ENST00000521871.1	-	6	2013	c.1598G>A	c.(1597-1599)cGa>cAa	p.R533Q	FBXO41_ENST00000520530.2_Missense_Mutation_p.R533Q|FBXO41_ENST00000295133.5_Missense_Mutation_p.R594Q			Q8TF61	FBX41_HUMAN	F-box protein 41	533	F-box.					intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						CCTCTCTGCTCGCCGACCCCG	0.627000													6	92					0	0	1	0	0
NXPH4	11247	broad.mit.edu	37	12	57619244	57619244	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:57619244G>A	ENST00000349394.5	+	2	816	c.641G>A	c.(640-642)gGg>gAg	p.G214E		NM_007224.3	NP_009155.1	O95158	NXPH4_HUMAN	neurexophilin 4	214	IV (linker domain).				neuropeptide signaling pathway	extracellular region				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)	10						GCACTGGCGGGGCCGCTTGGG	0.721000													18	18					0	0	1	0	0
TGFBR3	7049	broad.mit.edu	37	1	92224203	92224203	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:92224203C>A	ENST00000212355.4	-	4	816	c.351G>T	c.(349-351)gaG>gaT	p.E117D	TGFBR3_ENST00000370399.2_Missense_Mutation_p.E117D|TGFBR3_ENST00000468996.2_5'UTR|TGFBR3_ENST00000525962.1_Missense_Mutation_p.E117D	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	117					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TGGCAAGTCTCTCTGTCTTCA	0.502000													68	87					2.18329e-32	3.00385e-32	1	1	0
NINL	22981	broad.mit.edu	37	20	25456786	25456786	+	Silent	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr20:25456786G>A	ENST00000278886.6	-	17	3214	c.3141C>T	c.(3139-3141)acC>acT	p.T1047T	NINL_ENST00000422516.1_Intron	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	1047					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						GCGCTATTTTGGTCTCCCCCT	0.562000													39	157					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993042	28993042	+	Silent	SNP	T	T	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr18:28993042T>C	ENST00000359747.4	+	15	2693	c.2664T>C	c.(2662-2664)ccT>ccC	p.P888P	RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Silent_p.P869P	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	869					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTGACCTCCCTTTGCTCGGAC	0.418000													27	230					0	0	1	0	0
ZNF10	7556	broad.mit.edu	37	12	133732744	133732744	+	Silent	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:133732744G>T	ENST00000248211.6	+	5	1134	c.912G>T	c.(910-912)cgG>cgT	p.R304R	ZNF10_ENST00000426665.2_Silent_p.R304R|ZNF10_ENST00000402932.2_Silent_p.R170R|ZNF268_ENST00000416488.1_Intron|CTD-2140B24.4_ENST00000540096.2_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		CTTTCAGCCGGAGTTCTCACC	0.418000													40	89					6.5261e-18	8.10819e-18	1	1	0
IL10RA	3587	broad.mit.edu	37	11	117869643	117869643	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr11:117869643C>G	ENST00000227752.3	+	7	1144	c.1024C>G	c.(1024-1026)Ccc>Gcc	p.P342A	IL10RA_ENST00000545409.1_Missense_Mutation_p.P193A|IL10RA_ENST00000541785.1_Missense_Mutation_p.P322A|IL10RA_ENST00000533700.1_3'UTR	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha	342						integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		TGACCCTCACCCCCAGGCTGA	0.617000													40	17					0	0	1	0	0
ABCC6	368	broad.mit.edu	37	16	16297439	16297439	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr16:16297439C>A	ENST00000205557.7	-	8	855	c.826G>T	c.(826-828)Ggc>Tgc	p.G276C	ABCC6_ENST00000574094.1_5'UTR	NM_001171.5	NP_001162.4	O95255	MRP6_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	276					response to drug|visual perception	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(10)|lung(10)|ovary(1)|skin(6)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CCACTGCCGCCTTTCCTTTTA	0.582000													4	44					2.56e-06	2.74764e-06	1	1	0
SOBP	55084	broad.mit.edu	37	6	107955650	107955650	+	Silent	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:107955650G>A	ENST00000317357.5	+	6	2261	c.1602G>A	c.(1600-1602)ccG>ccA	p.P534P		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	534	Pro-rich.						metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		TGCCCCTACCGGTGCCCATCC	0.667000													8	33					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10362583	10362583	+	Silent	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:10362583G>A	ENST00000255381.2	-	15	1682	c.1572C>T	c.(1570-1572)atC>atT	p.I524I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	524	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CGATGAGCTCGATGCAGGCAG	0.468000													57	144					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197297746	197297746	+	Missense_Mutation	SNP	C	C	A	rs145525029		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:197297746C>A	ENST00000367400.3	+	2	400	c.265C>A	c.(265-267)Cca>Aca	p.P89T	CRB1_ENST00000538660.1_Missense_Mutation_p.P89T|CRB1_ENST00000367399.2_Missense_Mutation_p.P89T|CRB1_ENST00000535699.1_Missense_Mutation_p.P20T	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	89	EGF-like 2.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TGTGAACACCCCAGGAGAAAG	0.478000													63	53					1.80625e-27	2.38892e-27	1	1	0
COA6	388753	broad.mit.edu	37	1	234510059	234510059	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:234510059T>C	ENST00000366612.1	+	1	613	c.68T>C	c.(67-69)tTa>tCa	p.L23S	COA6_ENST00000366615.4_Missense_Mutation_p.L99S|COA6_ENST00000366613.1_Missense_Mutation_p.L69S					cytochrome c oxidase assembly factor 6 homolog (S. cerevisiae)																		TGGAAGTGTTTAGATGAGAAC	0.463000													45	119					0	0	1	0	0
FAM86JP	100125556	broad.mit.edu	37	3	125647396	125647396	+	RNA	SNP	T	T	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr3:125647396T>C	ENST00000485843.1	+	0	541					NR_024251.1																						TGTTTCCCTATGAAGAGCACT	0.502000													7	144					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216591874	216591874	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:216591874C>A	ENST00000366943.2	-	3	1019	c.633G>T	c.(631-633)tgG>tgT	p.W211C	USH2A_ENST00000366942.3_Missense_Mutation_p.W211C|USH2A_ENST00000307340.3_Missense_Mutation_p.W211C			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	211					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TAAGATGAATCCATTTCTTCA	0.333000										HNSCC(13;0.011)			37	121					1.60099e-16	1.96528e-16	1	1	0
PHLDB1	23187	broad.mit.edu	37	11	118516533	118516533	+	Missense_Mutation	SNP	T	T	A	rs146154740		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr11:118516533T>A	ENST00000361417.2	+	18	3908	c.3497T>A	c.(3496-3498)aTg>aAg	p.M1166K	PHLDB1_ENST00000356063.5_Missense_Mutation_p.M1119K|PHLDB1_ENST00000534672.1_3'UTR|PHLDB1_ENST00000524713.1_Missense_Mutation_p.M309K|PHLDB1_ENST00000527898.1_Missense_Mutation_p.M217K	NM_015157.3	NP_055972.1	Q86UU1	PHLB1_HUMAN	pleckstrin homology-like domain, family B, member 1	1166										breast(3)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(10)|liver(3)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(1)	46	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.0735)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		AACCGGCTCATGGAGTCGAGG	0.587000													5	91					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629121	47629121	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:47629121A>G	ENST00000546455.1	+	4	1006	c.275A>G	c.(274-276)tAc>tGc	p.Y92C	PCED1B_ENST00000432328.1_Missense_Mutation_p.Y92C					PC-esterase domain containing 1B																		GTACGTTTTTACTTCCTCACC	0.597000													124	162					0	0	1	0	0
ADCY1	107	broad.mit.edu	37	7	45747981	45747981	+	Silent	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr7:45747981G>T	ENST00000297323.7	+	18	2872	c.2850G>T	c.(2848-2850)acG>acT	p.T950T		NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	950					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	ACCTGAGCACGCTGGCGGACT	0.512000													84	24					1.51617e-55	2.12887e-55	1	1	0
ARNTL2	56938	broad.mit.edu	37	12	27553498	27553498	+	Silent	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:27553498T>A	ENST00000544915.1	+	9	1068	c.849T>A	c.(847-849)acT>acA	p.T283T	ARNTL2_ENST00000311001.5_Silent_p.T303T|ARNTL2_ENST00000266503.5_Silent_p.T317T|RP11-165P7.1_ENST00000500498.2_RNA|ARNTL2_ENST00000261178.5_Silent_p.T269T|ARNTL2_ENST00000542388.1_Silent_p.T232T|ARNTL2_ENST00000395901.2_Silent_p.T280T|ARNTL2_ENST00000546179.1_Silent_p.T280T	NM_020183.4	NP_064568.3	Q8WYA1	BMAL2_HUMAN	aryl hydrocarbon receptor nuclear translocator-like 2	317					circadian rhythm|entrainment of circadian clock|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|endometrium(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	21	Colorectal(261;0.0847)|Lung SC(9;0.184)					TCCATTGCACTGGTTACTTGA	0.328000													26	69					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			17	23					3.32936e-07	3.61121e-07	1	1	0
ROBO1	6091	broad.mit.edu	37	3	78710311	78710311	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr3:78710311G>A	ENST00000436010.2	-	14	3069	c.2072C>T	c.(2071-2073)aCg>aTg	p.T691M	ROBO1_ENST00000464233.1_Missense_Mutation_p.T730M|ROBO1_ENST00000495273.1_Missense_Mutation_p.T694M|ROBO1_ENST00000467549.1_Missense_Mutation_p.T694M			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	730	Fibronectin type-III 2.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TTTGGCTGGCGTCCTCACTTC	0.413000													7	34					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16670832	16670832	+	Nonsense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:16670832C>A	ENST00000513610.1	-	39	6140	c.5686G>T	c.(5686-5688)Gga>Tga	p.G1896*	MYO10_ENST00000427430.2_Nonsense_Mutation_p.G1253*|MYO10_ENST00000515803.1_Nonsense_Mutation_p.G1235*|MYO10_ENST00000274203.9_Nonsense_Mutation_p.G1253*|MYO10_ENST00000505695.1_Nonsense_Mutation_p.G1235*	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1896	FERM.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						ACCACGGATCCTGTCCGGAAG	0.577000													22	145					6.12954e-19	7.70892e-19	1	1	0
ADAM19	8728	broad.mit.edu	37	5	156964975	156964975	+	Silent	SNP	T	T	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:156964975T>G	ENST00000257527.4	-	4	354	c.276A>C	c.(274-276)acA>acC	p.T92T	ADAM19_ENST00000517905.1_Silent_p.T92T|ADAM19_ENST00000394020.1_Silent_p.T94T|ADAM19_ENST00000430702.2_5'UTR	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	92					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AATGGGTTTCTGTGTAGGAAG	0.418000													21	50					0	0	1	0	0
ZNF257	113835	broad.mit.edu	37	19	22270960	22270960	+	Nonsense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:22270960T>A	ENST00000594947.1	+	4	552	c.408T>A	c.(406-408)tgT>tgA	p.C136*	ZNF257_ENST00000600162.1_3'UTR	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	136					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTAACCAATGTCTGATAACTA	0.313000													26	78					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49705106	49705106	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:49705106T>A	ENST00000433368.2	-	2	142	c.73A>T	c.(73-75)Aca>Tca	p.T25S	CRISP3_ENST00000393666.1_Missense_Mutation_p.T2S|CRISP3_ENST00000263045.4_Missense_Mutation_p.T15S|CRISP3_ENST00000423399.2_Intron|CRISP3_ENST00000371159.4_Missense_Mutation_p.T33S	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	2					innate immune response	proteinaceous extracellular matrix|specific granule				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GGGAATAATGTCATTGCTGGG	0.428000													26	79					0	0	1	0	0
PANK4	55229	broad.mit.edu	37	1	2441345	2441345	+	Silent	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:2441345C>A	ENST00000378466.3	-	18	2076	c.2064G>T	c.(2062-2064)ctG>ctT	p.L688L	PANK4_ENST00000435556.3_Silent_p.L649L	NM_018216.1	NP_060686.1	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	688					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			breast(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	23	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		GCACCAGCAGCAGCCTCTCTT	0.652000													6	10					0.0215528	0.0216584	1	1	0
CDH4	1002	broad.mit.edu	37	20	60318792	60318792	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr20:60318792G>T	ENST00000360469.5	+	3	431	c.343G>T	c.(343-345)Gcc>Tcc	p.A115S	RP11-429E11.2_ENST00000447909.1_RNA|RP11-429E11.2_ENST00000442888.1_RNA|CDH4_ENST00000543233.1_Missense_Mutation_p.A41S	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	115					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GAAATGGGACGCCGTGGTGCG	0.632000													7	6					8.12818e-05	8.50142e-05	1	1	0
ZNF599	148103	broad.mit.edu	37	19	35250893	35250893	+	Silent	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:35250893C>T	ENST00000329285.7	-	4	1186	c.813G>A	c.(811-813)acG>acA	p.T271T		NM_001007248.2	NP_001007249.1	Q96NL3	ZN599_HUMAN	zinc finger protein 599	271					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|skin(1)	24	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GCTGGTGCTCCGTGAGGTGAA	0.458000													76	145					0	0	1	0	0
MYLK4	340156	broad.mit.edu	37	6	2680456	2680456	+	Splice_Site	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr6:2680456T>A	ENST00000274643.7	-	8	1099	c.758_splice	c.e8+1	p.R253_splice	MYLK4_ENST00000268446.5_Intron	NM_001012418.3	NP_001012418.2	Q86YV6	MYLK4_HUMAN	myosin light chain kinase family, member 4	253	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23	Ovarian(93;0.0412)	all_hematologic(90;0.0897)				TAGACATACCTTCTGGCCAAT	0.418000													105	266					0	0	1	0	0
LHX8	431707	broad.mit.edu	37	1	75609565	75609565	+	Nonsense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:75609565G>T	ENST00000294638.5	+	7	1310	c.646G>T	c.(646-648)Gag>Tag	p.E216*	LHX8_ENST00000356261.3_Nonsense_Mutation_p.E206*	NM_001001933.1	NP_001001933.1	Q68G74	LHX8_HUMAN	LIM homeobox 8	216						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(18)|ovary(3)|urinary_tract(1)	30						CCTCCTCACAGAGCAAGATGT	0.383000													20	40					1.66031e-10	1.88046e-10	1	1	0
GPR162	27239	broad.mit.edu	37	12	6933929	6933929	+	Silent	SNP	T	T	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:6933929T>C	ENST00000311268.3	+	2	1652	c.865T>C	c.(865-867)Ttg>Ctg	p.L289L	GPR162_ENST00000428545.2_Intron|GPR162_ENST00000382315.3_Intron	NM_019858.1	NP_062832.1	Q16538	GP162_HUMAN	G protein-coupled receptor 162	289						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(2)|skin(1)	18						GGTGCCCATCTTGGTGAGATC	0.572000													38	49					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26942151	26942151	+	Silent	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:26942151C>A	ENST00000528896.2	-	39	6713	c.6639G>T	c.(6637-6639)cgG>cgT	p.R2213R	SPAG5-AS1_ENST00000424210.1_RNA|SPAG5-AS1_ENST00000554154.1_RNA|KIAA0100_ENST00000389003.3_Silent_p.R2070R|KIAA0100_ENST00000544884.1_Silent_p.R2070R	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	2213						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CAATGAGGAGCCGGGCTTTCT	0.522000													202	169					9.37032e-68	1.32477e-67	1	1	0
MOGS	7841	broad.mit.edu	37	2	74688553	74688553	+	Missense_Mutation	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:74688553C>T	ENST00000233616.4	-	4	2525	c.2363G>A	c.(2362-2364)cGt>cAt	p.R788H	MOGS_ENST00000452063.2_Missense_Mutation_p.R682H|MOGS_ENST00000409065.1_3'UTR	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	788					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity			cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						CACGTTGGCACGGAGCTCACC	0.607000													13	124					0	0	1	0	0
COL6A2	1292	broad.mit.edu	37	21	47552155	47552155	+	Missense_Mutation	SNP	G	G	C	rs145381639		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr21:47552155G>C	ENST00000300527.4	+	28	2853	c.2749G>C	c.(2749-2751)Gtg>Ctg	p.V917L		NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	917	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		CTTCTCGCACGTGGGCGCAGG	0.682000													5	17					0	0	1	0	0
DIRAS1	148252	broad.mit.edu	37	19	2717862	2717862	+	Silent	SNP	C	C	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:2717862C>G	ENST00000586572.1	-	3	447	c.222G>C	c.(220-222)ggG>ggC	p.G74G	DIRAS1_ENST00000585334.1_5'UTR|DIRAS1_ENST00000323469.4_5'UTR																							CTGCAAGAACCCCAGACCGAG	0.697000													5	5					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210558906	210558906	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:210558906G>A	ENST00000360351.4	+	7	2518	c.2012G>A	c.(2011-2013)aGg>aAg	p.R671K	MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.R667K|MAP2_ENST00000361559.4_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	671					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GGAGAGAAAAGGGACCTCCAC	0.413000													51	130					0	0	1	0	0
SSX9	280660	broad.mit.edu	37	X	48159110	48159110	+	Silent	SNP	G	G	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chrX:48159110G>C	ENST00000376909.1	-	6	485	c.423C>G	c.(421-423)ccC>ccG	p.P141P	SSX9_ENST00000407081.2_Silent_p.P141P																breast(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|stomach(1)	8						GTTTTCCCGGGGGGCACAGCT	0.483000													57	279					0	0	1	0	0
CMYA5	202333	broad.mit.edu	37	5	79030054	79030054	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:79030054A>T	ENST00000446378.2	+	2	5497	c.5466A>T	c.(5464-5466)aaA>aaT	p.K1822N		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1822						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		TAGAACAAAAAAAGACAGAAA	0.388000													16	51					0	0	1	0	0
EIF2AK3	9451	broad.mit.edu	37	2	88870405	88870405	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:88870405A>G	ENST00000303236.3	-	14	3273	c.2972T>C	c.(2971-2973)aTg>aCg	p.M991T	EIF2AK3_ENST00000419748.1_Missense_Mutation_p.M840T|AC104134.2_ENST00000413234.1_RNA	NM_004836.5	NP_004827.4	Q9NZJ5	E2AK3_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 3	991	Protein kinase.				activation of caspase activity|bone mineralization|calcium-mediated signaling|chondrocyte development|endocrine pancreas development|endoplasmic reticulum organization|endoplasmic reticulum unfolded protein response|ER overload response|insulin secretion|insulin-like growth factor receptor signaling pathway|negative regulation of myelination|negative regulation of translational initiation in response to stress|protein autophosphorylation|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|identical protein binding			ovary(3)	3						CTCTGGGCTCATATACAGTTT	0.453000													199	95					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23527089	23527089	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:23527089C>A	ENST00000296682.3	+	11	2074	c.1892C>A	c.(1891-1893)aCa>aAa	p.T631K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	631					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						AGGAGACACACAGGGGAGAAG	0.612000										HNSCC(3;0.000094)			26	105					5.43694e-19	6.88007e-19	1	1	0
DTWD1	56986	broad.mit.edu	37	15	49917603	49917603	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr15:49917603C>A	ENST00000251250.6	+	3	446	c.239C>A	c.(238-240)cCt>cAt	p.P80H	DTWD1_ENST00000558653.1_Missense_Mutation_p.P80H|DTWD1_ENST00000403028.3_Missense_Mutation_p.P80H|DTWD1_ENST00000559223.1_3'UTR|DTWD1_ENST00000329873.5_Missense_Mutation_p.P80H	NM_020234.5	NP_064619.2	Q8N5C7	DTWD1_HUMAN	DTW domain containing 1	80										endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;0.0384)		all cancers(107;3.27e-08)|GBM - Glioblastoma multiforme(94;7.6e-05)		GAAAATGTACCTATTGAACAG	0.318000													10	21					0.00621372	0.00627493	1	1	0
WWC1	23286	broad.mit.edu	37	5	167855769	167855769	+	Silent	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:167855769G>A	ENST00000265293.4	+	13	2479	c.1977G>A	c.(1975-1977)gcG>gcA	p.A659A	WWC1_ENST00000521089.1_Silent_p.A659A	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	659	C2.				cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CAGTGGGTGCGACCCGAATTC	0.552000													4	62					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84636129	84636129	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr7:84636129G>T	ENST00000284136.6	-	16	1940	c.1897C>A	c.(1897-1899)Cat>Aat	p.H633N	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	633	Ig-like C2-type.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						TCCTCTCGATGCTCATCCCCT	0.383000													70	174					2.69673e-31	3.61327e-31	1	1	0
HSF2BP	11077	broad.mit.edu	37	21	45053213	45053213	+	Silent	SNP	C	C	G	rs114602699	byFrequency	TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr21:45053213C>G	ENST00000291560.2	-	5	712	c.381G>C	c.(379-381)gcG>gcC	p.A127A	HSF2BP_ENST00000542962.1_Silent_p.A52A	NM_007031.1	NP_008962.1	O75031	HSF2B_HUMAN	heat shock transcription factor 2 binding protein	127					spermatogenesis|transcription from RNA polymerase II promoter	cytosol	binding			kidney(2)|large_intestine(3)|prostate(1)|skin(1)	7				STAD - Stomach adenocarcinoma(101;0.18)		AGAGGGTACACGCTGCTGCTC	0.498000													14	71					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81734876	81734876	+	Missense_Mutation	SNP	A	A	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:81734876A>T	ENST00000550584.2	-	19	2669	c.2374T>A	c.(2374-2376)Tac>Aac	p.Y792N	PPFIA2_ENST00000407050.4_Missense_Mutation_p.Y718N|PPFIA2_ENST00000541017.1_Missense_Mutation_p.Y9N|PPFIA2_ENST00000333447.7_Missense_Mutation_p.Y774N|PPFIA2_ENST00000541570.2_Missense_Mutation_p.Y359N|PPFIA2_ENST00000549396.1_Missense_Mutation_p.Y792N|PPFIA2_ENST00000552948.1_Missense_Mutation_p.Y792N|PPFIA2_ENST00000443686.3_Missense_Mutation_p.Y693N|PPFIA2_ENST00000550359.2_Missense_Mutation_p.Y639N|PPFIA2_ENST00000548586.1_Missense_Mutation_p.Y792N|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000549325.1_Missense_Mutation_p.Y774N	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	718										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TCATTGTGGTAGGAAGAAGGG	0.468000													36	56					0	0	1	0	0
PRIMA1	145270	broad.mit.edu	37	14	94187868	94187868	+	Silent	SNP	A	A	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr14:94187868A>G	ENST00000393140.1	-	5	486	c.384T>C	c.(382-384)aaT>aaC	p.N128N	PRIMA1_ENST00000316227.3_3'UTR|PRIMA1_ENST00000393143.1_Silent_p.N128N	NM_178013.3	NP_821092.1	Q86XR5	PRIMA_HUMAN	proline rich membrane anchor 1	128					neurotransmitter catabolic process	cell junction|integral to membrane|synapse				endometrium(1)|large_intestine(2)|lung(3)|skin(1)	7		all_cancers(154;0.127)		Epithelial(152;0.138)|COAD - Colon adenocarcinoma(157;0.229)		CGCTGGTGCCATTTTCGTCTT	0.557000													10	34					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	36					0	0	1	0	0
CCDC147	159686	broad.mit.edu	37	10	106214253	106214253	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr10:106214253G>A	ENST00000369704.3	+	18	2718	c.2584G>A	c.(2584-2586)Gga>Aga	p.G862R		NM_001008723.1	NP_001008723.1	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	862										NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	52		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		TACTGGGGGCGGATTTCCTCT	0.463000													24	214					0	0	1	0	0
ZNF32	7580	broad.mit.edu	37	10	44139763	44139763	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr10:44139763T>G	ENST00000395797.1	-	3	745	c.557A>C	c.(556-558)gAg>gCg	p.E186A	ZNF32-AS1_ENST00000453284.1_RNA|ZNF32-AS3_ENST00000458063.1_RNA|ZNF32_ENST00000374433.2_Missense_Mutation_p.E186A	NM_001005368.1	NP_001005368.1	P17041	ZNF32_HUMAN	zinc finger protein 32	186					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|ovary(1)|pancreas(1)|urinary_tract(1)	14		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)		ATAGGGCTTCTCACCACTGTG	0.473000													14	145					0	0	1	0	0
KRTAP11-1	337880	broad.mit.edu	37	21	32253606	32253606	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr21:32253606G>C	ENST00000332378.4	-	1	268	c.238C>G	c.(238-240)Cct>Gct	p.P80A		NM_175858.2	NP_787054.1	Q8IUC1	KR111_HUMAN	keratin associated protein 11-1	80						keratin filament	structural molecule activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|pancreas(1)	18						ACCTGGCAAGGGTTGGAGACA	0.562000													16	101					0	0	1	0	0
VCL	7414	broad.mit.edu	37	10	75843123	75843123	+	Splice_Site	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr10:75843123G>T	ENST00000211998.4	+	8	968		c.e8-1		VCL_ENST00000417648.2_Intron|VCL_ENST00000478896.2_Intron|VCL_ENST00000372755.3_Splice_Site	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin						adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					CTTTATTTTAGGGGATGCTGG	0.393000													28	122					0.00106085	0.00109283	1	1	0
LRP1	4035	broad.mit.edu	37	12	57567573	57567573	+	Silent	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:57567573C>T	ENST00000243077.3	+	22	3823	c.3357C>T	c.(3355-3357)atC>atT	p.I1119I		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1119	LDL-receptor class A 9.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity	p.I1119I(1)		NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CTCGGTGCATCAGCAAAGCGT	0.627000													19	173					0	0	1	0	0
C1QTNF9	338872	broad.mit.edu	37	13	24895903	24895903	+	Silent	SNP	G	G	A	rs143548748		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr13:24895903G>A	ENST00000382071.2	+	4	1084	c.999G>A	c.(997-999)ccG>ccA	p.P333P	C1QTNF9_ENST00000332018.4_Silent_p.P333P			P0C862	C1T9A_HUMAN	C1q and tumor necrosis factor related protein 9	333	C1q.					collagen	hormone activity			endometrium(1)|kidney(2)|lung(6)	9		all_cancers(29;3.55e-20)|all_epithelial(30;4.25e-17)|all_lung(29;1.04e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.00565)|Epithelial(112;0.027)|OV - Ovarian serous cystadenocarcinoma(117;0.115)|Lung(94;0.159)		TCAGCAGCCCGTGACAGAGGA	0.448000													36	167					0	0	1	0	0
SERPINA3	12	broad.mit.edu	37	14	95081408	95081408	+	Silent	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr14:95081408C>T	ENST00000553947.1	+	5	1593	c.705C>T	c.(703-705)taC>taT	p.Y235Y	SERPINA3_ENST00000467132.1_Silent_p.Y210Y|SERPINA3_ENST00000393078.3_Silent_p.Y210Y|SERPINA3_ENST00000393080.4_Silent_p.Y210Y|SERPINA3_ENST00000556388.1_Intron			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	210					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		TGGTGAATTACATCTTCTTTA	0.463000													15	135					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211280664	211280664	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:211280664G>T	ENST00000367007.4	-	2	304	c.135C>A	c.(133-135)agC>agA	p.S45R	KCNH1_ENST00000271751.4_Missense_Mutation_p.S45R	NM_002238.3|NM_172362.2	NP_002229.1|NP_758872.1	O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	45	PAS.				myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		ATCCATCATTGCTGTACACAA	0.408000													17	184					3.41278e-10	3.84407e-10	1	1	0
AGO3	192669	broad.mit.edu	37	1	36520728	36520728	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:36520728T>A	ENST00000373191.4	+	18	2805	c.2456T>A	c.(2455-2457)gTg>gAg	p.V819E	AGO3_ENST00000246314.6_Missense_Mutation_p.V585E|AGO3_ENST00000471099.1_3'UTR	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		TATCATCTTGTGGACAAAGAA	0.423000													10	14					0	0	1	0	0
CDC14A	8556	broad.mit.edu	37	1	100928388	100928388	+	Missense_Mutation	SNP	C	C	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:100928388C>G	ENST00000336454.3	+	9	1144	c.789C>G	c.(787-789)ttC>ttG	p.F263L	CDC14A_ENST00000542213.1_Missense_Mutation_p.F205L|CDC14A_ENST00000370125.2_3'UTR|RP5-837M10.4_ENST00000432210.1_RNA|CDC14A_ENST00000361544.6_Missense_Mutation_p.F263L|CDC14A_ENST00000370124.3_Missense_Mutation_p.F263L|CDC14A_ENST00000544534.1_Missense_Mutation_p.F263L	NM_003672.3	NP_003663.2	Q9UNH5	CC14A_HUMAN	cell division cycle 14A	263	B.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		TGCGAAGGTTCCTGAACATCT	0.557000													22	42					0	0	1	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45885799	45885799	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:45885799G>A	ENST00000418234.2	-	12	2512	c.2434C>T	c.(2434-2436)Cgg>Tgg	p.R812W	PPP1R13L_ENST00000360957.5_Missense_Mutation_p.R812W	NM_001142502.1	NP_001135974.1	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13 like	812	SH3.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		AAGTAGTTCCGCGGCACGTAG	0.672000													13	154					0	0	1	0	0
TRIM49	57093	broad.mit.edu	37	11	89531678	89531678	+	Missense_Mutation	SNP	T	T	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr11:89531678T>G	ENST00000329758.1	-	8	1307	c.979A>C	c.(979-981)Agt>Cgt	p.S327R	TRIM49_ENST00000532501.2_Missense_Mutation_p.S250R	NM_020358.2	NP_065091.1	P0CI25	TRI49_HUMAN	tripartite motif containing 49	327	B30.2/SPRY.					intracellular	zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|liver(1)|lung(14)|prostate(1)|skin(2)|stomach(1)	27		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GCAAGAAAACTTCTAGGTGTT	0.418000													6	79					0	0	1	0	0
ITGBL1	9358	broad.mit.edu	37	13	102235664	102235664	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr13:102235664T>A	ENST00000376180.3	+	6	1045	c.826T>A	c.(826-828)Tgt>Agt	p.C276S	ITGBL1_ENST00000545560.2_Missense_Mutation_p.C135S|ITGBL1_ENST00000376162.3_Missense_Mutation_p.C183S	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	276	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGAGAGGGACTGTAGAGCTGT	0.493000													15	209					0	0	1	0	0
TBCK	93627	broad.mit.edu	37	4	107230101	107230101	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr4:107230101T>A	ENST00000273980.4	-	3	464	c.17A>T	c.(16-18)gAc>gTc	p.D6V	TBCK_ENST00000394708.2_Missense_Mutation_p.D6V|TBCK_ENST00000361687.4_Missense_Mutation_p.D6V|TBCK_ENST00000394706.3_Missense_Mutation_p.D6V|TBCK_ENST00000432496.2_Missense_Mutation_p.D6V			Q8TEA7	TBCK_HUMAN	TBC1 domain containing kinase	6	Protein kinase.					intracellular	Rab GTPase activator activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)	25						CATTTCAGCGTCCTTCAGGGG	0.423000													21	50					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17073398	17073398	+	Silent	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr22:17073398G>A	ENST00000359963.3	-	1	302	c.43C>T	c.(43-45)Ctg>Ttg	p.L15L		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	15					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TTCAGTGCCAGCCGCTGGGGC	0.642000													24	54					0	0	1	0	0
INSC	387755	broad.mit.edu	37	11	15243128	15243128	+	Silent	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr11:15243128C>T	ENST00000379554.3	+	8	1112	c.1066C>T	c.(1066-1068)Ctg>Ttg	p.L356L	INSC_ENST00000528567.1_Silent_p.L309L|INSC_ENST00000530161.1_Silent_p.L309L|INSC_ENST00000525218.1_Silent_p.L267L|INSC_ENST00000379556.3_Silent_p.L309L|INSC_ENST00000424273.1_Silent_p.L267L|INSC_ENST00000447214.2_3'UTR	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	356					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						CTCCCCACACCTGCCCGTCAC	0.642000													13	78					0	0	1	0	0
FAM69A	388650	broad.mit.edu	37	1	93312897	93312897	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:93312897T>A	ENST00000370310.4	-	4	387	c.317A>T	c.(316-318)gAt>gTt	p.D106V		NM_001006605.4|NM_001252269.1|NM_001252271.1	NP_001006606.2|NP_001239198.1|NP_001239200.1	Q5T7M9	FA69A_HUMAN	family with sequence similarity 69, member A	106						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)	4		all_lung(203;0.00265)|Lung NSC(277;0.00562)|all_neural(321;0.185)|Melanoma(281;0.192)|Glioma(108;0.203)		GBM - Glioblastoma multiforme(16;0.000563)|all cancers(265;0.000751)|Epithelial(280;0.127)		TGGTAGATTATCCCAAATCCC	0.318000													16	18					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154544244	154544244	+	Silent	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:154544244C>T	ENST00000368476.3	+	5	1209	c.945C>T	c.(943-945)agC>agT	p.S315S		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	315					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	TCGTCACCAGCGTGTGCGTGC	0.622000													47	54					0	0	1	0	0
TCERG1	10915	broad.mit.edu	37	5	145859638	145859638	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr5:145859638G>T	ENST00000296702.5	+	12	1905	c.1867G>T	c.(1867-1869)Gtt>Ttt	p.V623F	TCERG1_ENST00000394421.2_Missense_Mutation_p.V602F	NM_006706.3	NP_006697.2	O14776	TCRG1_HUMAN	transcription elongation regulator 1	623					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(18)|lung(9)|ovary(2)|prostate(3)|skin(1)	46		Lung NSC(249;0.00188)|all_lung(500;0.00307)|all_neural(839;0.0424)|Breast(839;0.0743)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGATGAGCCTGTTAAAGCAAA	0.279000													15	32					1.02788e-11	1.19049e-11	1	1	0
FBN1	2200	broad.mit.edu	37	15	48903020	48903020	+	Missense_Mutation	SNP	A	A	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr15:48903020A>G	ENST00000316623.5	-	4	706	c.251T>C	c.(250-252)aTt>aCt	p.I84T		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	84	EGF-like 1.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ATGCCGGCAAATGGCTGTGAA	0.488000													6	32					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21599382	21599382	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr7:21599382G>A	ENST00000328843.6	+	4	885	c.854G>A	c.(853-855)aGa>aAa	p.R285K	DNAH11_ENST00000409508.3_Missense_Mutation_p.R285K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	285	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATGATGAGGAGAGAAAATCTG	0.353000									Kartagener syndrome				24	11					0	0	1	0	0
FANCI	55215	broad.mit.edu	37	15	89837159	89837159	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr15:89837159T>C	ENST00000310775.7	+	23	2473	c.2387T>C	c.(2386-2388)aTg>aCg	p.M796T	FANCI_ENST00000300027.8_Missense_Mutation_p.M796T	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	796					cell cycle|DNA repair	nucleoplasm	protein binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					AAAACTAAAATGGCCAACAAG	0.373000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				54	60					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7699788	7699788	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:7699788C>A	ENST00000572933.1	+	50	9141	c.7681C>A	c.(7681-7683)Cag>Aag	p.Q2561K	DNAH2_ENST00000389173.2_Missense_Mutation_p.Q2561K			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	2561	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CTAGAAGTCCCAGATCATCCG	0.532000													8	54					1.06961e-07	1.16633e-07	1	1	0
SART3	9733	broad.mit.edu	37	12	108918236	108918236	+	Silent	SNP	A	A	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:108918236A>C	ENST00000228284.3	-	18	2805	c.2571T>G	c.(2569-2571)gcT>gcG	p.A857A	SART3_ENST00000431469.2_Silent_p.A821A	NM_014706.3	NP_055521.1	Q15020	SART3_HUMAN	squamous cell carcinoma antigen recognized by T cells 3	857	RRM 2.				RNA processing	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|stomach(1)	25						TCTTCATCACAGCCTGCGACG	0.527000									Porokeratosis				27	104					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2705056	2705056	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:2705056C>A	ENST00000399655.1	+	20	2945	c.2680C>A	c.(2680-2682)Cac>Aac	p.H894N	CACNA1C_ENST00000399601.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399595.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399629.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000402845.3_Missense_Mutation_p.H894N|CACNA1C_ENST00000399649.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399641.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399606.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000406454.3_Missense_Mutation_p.H894N|CACNA1C_ENST00000399637.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399591.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399597.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399634.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000335762.5_Missense_Mutation_p.H919N|CACNA1C_ENST00000399644.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399617.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000347598.4_Missense_Mutation_p.H894N|CACNA1C_ENST00000327702.7_Missense_Mutation_p.H894N|CACNA1C_ENST00000480911.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399638.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000344100.3_Missense_Mutation_p.H894N|CACNA1C_ENST00000399603.1_Missense_Mutation_p.H894N|CACNA1C_ENST00000399621.1_Missense_Mutation_p.H894N	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	894					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	CCTCCAGTGCCACCGCATTGT	0.582000													28	82					7.26314e-15	8.70727e-15	1	1	0
POTEC	388468	broad.mit.edu	37	18	14543000	14543000	+	Missense_Mutation	SNP	T	T	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr18:14543000T>C	ENST00000358970.5	-	1	145	c.146A>G	c.(145-147)cAc>cGc	p.H49R	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	49										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GGAGTCGTCGTGGTCTCCAGA	0.587000													32	263					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179410280	179410280	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:179410280G>T	ENST00000589042.1	-	344	95781	c.95557C>A	c.(95557-95559)Cgc>Agc	p.R31853S	TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R22788S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R30212S|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R29285S|TTN-AS1_ENST00000586831.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.R22980S|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R22913S|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000438095.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30212							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGTGTCCAGCGCAGGCTCTTC	0.483000													68	379					5.44642e-36	7.54403e-36	1	1	0
HEPHL1	341208	broad.mit.edu	37	11	93822102	93822102	+	Silent	SNP	C	C	T	rs116956001	by1000genomes	TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr11:93822102C>T	ENST00000315765.9	+	12	2270	c.2262C>T	c.(2260-2262)ttC>ttT	p.F754F		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	754	Plastocyanin-like 5.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ACTGGGAGTTCGAAAAGCAGC	0.542000													6	102					0	0	1	0	0
LRIT1	26103	broad.mit.edu	37	10	85992334	85992334	+	Silent	SNP	A	A	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr10:85992334A>T	ENST00000372105.3	-	4	1242	c.1221T>A	c.(1219-1221)ctT>ctA	p.L407L		NM_015613.2	NP_056428.1	Q9P2V4	LRIT1_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 1	407						integral to endoplasmic reticulum membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|skin(1)	23						GGAAGTGCTCAAGGGTCAGCT	0.607000													27	113					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210558531	210558531	+	Missense_Mutation	SNP	A	A	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr2:210558531A>C	ENST00000360351.4	+	7	2143	c.1637A>C	c.(1636-1638)aAg>aCg	p.K546T	MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.K542T|MAP2_ENST00000361559.4_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	546					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	GACAAAGATAAGATTGAAGGA	0.378000													8	158					0	0	1	0	0
PEX11B	8799	broad.mit.edu	37	1	145522532	145522532	+	Silent	SNP	C	C	G			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr1:145522532C>G	ENST00000369306.3	+	4	542	c.393C>G	c.(391-393)ctC>ctG	p.L131L	PEX11B_ENST00000537888.1_Silent_p.L117L	NM_003846.2	NP_003837.1	O96011	PX11B_HUMAN	peroxisomal biogenesis factor 11 beta	131					peroxisome fission|signal transduction	integral to peroxisomal membrane	protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)	7	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TGTTTTCCCTCATCATGAATT	0.428000													118	118					0	0	1	0	0
ACIN1	22985	broad.mit.edu	37	14	23564368	23564368	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr14:23564368G>T	ENST00000262710.1	-	1	455	c.128C>A	c.(127-129)cCg>cAg	p.P43Q	C14orf119_ENST00000319074.4_5'UTR|ACIN1_ENST00000555053.1_Missense_Mutation_p.P43Q|ACIN1_ENST00000457657.1_Missense_Mutation_p.P43Q	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	43					apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		GGGCATCTTCGGTAATTTCCG	0.627000													31	62					2.49534e-26	3.27914e-26	1	1	0
SYT17	51760	broad.mit.edu	37	16	19236033	19236033	+	Silent	SNP	T	T	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr16:19236033T>C	ENST00000562034.1	+	5	4716	c.918T>C	c.(916-918)caT>caC	p.H306H	SYT17_ENST00000562711.2_Silent_p.H363H|SYT17_ENST00000355377.2_Silent_p.H367H|SYT17_ENST00000568433.1_Silent_p.H61H|SYT17_ENST00000568115.1_Silent_p.H306H			Q9BSW7	SYT17_HUMAN	synaptotagmin XVII	367						membrane|synaptic vesicle	transporter activity			NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)	17						AGCTGGTGCATGGACTCAAAC	0.423000													36	75					0	0	1	0	0
NELL1	4745	broad.mit.edu	37	11	21594927	21594927	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr11:21594927G>T	ENST00000298925.5	+	20	2591	c.2438G>T	c.(2437-2439)gGa>gTa	p.G813V	NELL1_ENST00000325319.5_Missense_Mutation_p.G728V|NELL1_ENST00000357134.5_Missense_Mutation_p.G785V|NELL1_ENST00000529218.1_3'UTR|NELL1_ENST00000532434.1_Missense_Mutation_p.G738V			Q92832	NELL1_HUMAN	NEL-like 1 (chicken)	785					cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			NS(1)|breast(3)|endometrium(5)|kidney(3)|large_intestine(15)|lung(36)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	70						ACGATGGCTGGATCTCCCTGC	0.493000													32	183					2.61193e-14	3.11306e-14	1	1	0
TFR2	7036	broad.mit.edu	37	7	100228605	100228605	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr7:100228605G>C	ENST00000462107.1	-	10	1464	c.1177C>G	c.(1177-1179)Ccc>Gcc	p.P393A	TFR2_ENST00000431692.1_Missense_Mutation_p.P307R|TFR2_ENST00000223051.3_Missense_Mutation_p.P393A|TFR2_ENST00000544242.1_5'UTR			Q9UP52	TFR2_HUMAN	transferrin receptor 2	393					cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					CGTGGCCCGGGGCCCAGGTGA	0.617000													7	17					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29628035	29628035	+	Missense_Mutation	SNP	C	C	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:29628035C>A	ENST00000318184.5	-	14	1558	c.1559G>T	c.(1558-1560)cGt>cTt	p.R520L	OVCH1-AS1_ENST00000549411.1_Intron|OVCH1-AS1_ENST00000551108.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	520	CUB 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity	p.R520H(1)		NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					GCCTTGTAAACGATTTTTACC	0.338000													3	14					6.4e-05	6.76438e-05	1	1	0
MYH15	22989	broad.mit.edu	37	3	108219048	108219048	+	Missense_Mutation	SNP	G	G	C			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr3:108219048G>C	ENST00000273353.3	-	5	529	c.473C>G	c.(472-474)gCc>gGc	p.A158G		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	158	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TTTGTAGGCGGCCATGACTTC	0.478000													18	53					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64880761	64880761	+	Missense_Mutation	SNP	T	T	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr17:64880761T>A	ENST00000533854.1	+	5	790	c.553T>A	c.(553-555)Tcc>Acc	p.S185T	CACNG5_ENST00000307139.3_Missense_Mutation_p.S185T|CACNG5_ENST00000169565.3_Missense_Mutation_p.S185T			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	185					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CGCCGCCATCTCCTTCCTTTT	0.557000													38	136					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50684208	50684208	+	Silent	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr3:50684208C>T	ENST00000446044.1	+	11	1463	c.867C>T	c.(865-867)ccC>ccT	p.P289P	MAPKAPK3_ENST00000357955.2_Silent_p.P289P	NM_001243926.1	NP_001230855.1	Q16644	MAPK3_HUMAN	mitogen-activated protein kinase-activated protein kinase 3	289	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		AGACAGACCCCACAGAGAGGC	0.617000													42	15					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18270309	18270309	+	Missense_Mutation	SNP	G	G	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr10:18270309G>T	ENST00000377369.2	+	6	1266	c.993G>T	c.(991-993)gaG>gaT	p.E331D	SLC39A12_ENST00000377371.3_Missense_Mutation_p.E331D|SLC39A12_ENST00000539911.1_Missense_Mutation_p.E197D|SLC39A12_ENST00000377374.4_Missense_Mutation_p.E331D	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	331					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						TTTCTAAGGAGGACTTTAAGC	0.488000													21	122					2.4624e-09	2.74343e-09	1	1	0
MTAP	4507	broad.mit.edu	37	9	21854737	21854737	+	Silent	SNP	C	C	T			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr9:21854737C>T	ENST00000380172.4	+	6	764	c.558C>T	c.(556-558)ttC>ttT	p.F186F	MTAP_ENST00000580900.1_Silent_p.F186F|MTAP_ENST00000460874.2_Silent_p.F203F|RP11-145E5.5_ENST00000404796.2_Intron	NM_002451.3	NP_002442.2	Q13126	MTAP_HUMAN	methylthioadenosine phosphorylase	186					nucleoside metabolic process	cytoplasm	phosphorylase activity|S-methyl-5-thioadenosine phosphorylase activity	p.0(1)|p.0?(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|lung(3)|pancreas(1)	10		all_cancers(5;0)|Hepatocellular(5;0.00162)|Colorectal(97;0.173)		GBM - Glioblastoma multiforme(3;0)|Lung(24;2.24e-57)|LUSC - Lung squamous cell carcinoma(38;1.97e-36)|STAD - Stomach adenocarcinoma(4;3.26e-05)|OV - Ovarian serous cystadenocarcinoma(39;0.00931)|COAD - Colon adenocarcinoma(8;0.15)	Adenine(DB00173)	GCTTCATGTTCCGCACCTGGG	0.532000													21	84					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913439	6913439	+	Missense_Mutation	SNP	G	G	A			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr11:6913439G>A	ENST00000299459.2	-	1	391	c.293C>T	c.(292-294)gCa>gTa	p.A98V		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAGTCGAGCTGCGCAAAGTGT	0.478000													14	82					0	0	1	0	0
LINC00987	100499405	broad.mit.edu	37	12	9392739	9392740	+	RNA	INS	-	-	TCTTCCTCCTCC	rs71045240		TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr12:9392739_9392740insTCTTCCTCCTCC	ENST00000427111.3	+	0	141_142					NR_036466.1																						caccatcaccttcttcctcccc	0.545													4	6	---	---	---	---					
DPPA3P2	400206	broad.mit.edu	37	14	36841115	36841115	+	RNA	DEL	T	T	-			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr14:36841115delT	ENST00000557188.1	+	0	746																											TTCTTGCACCTTTTTTTCTTG	0.358													7	545	---	---	---	---					
CNGB1	1258	broad.mit.edu	37	16	57983331	57983331	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr16:57983331delC	ENST00000564448.1	-	14	1089	c.1029delG	c.(1027-1029)cgfs	p.R343fs	CNGB1_ENST00000251102.8_Frame_Shift_Del_p.R349fs			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	349					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						cctcttcAATCCGGGACAGCT	0.557													40	62	---	---	---	---					
RNF165	494470	broad.mit.edu	37	18	44030744	44030744	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr18:44030744delC	ENST00000269439.7	+	6	849	c.798delC	c.(796-798)ttfs	p.F266fs	RNF165_ENST00000543885.1_Frame_Shift_Del_p.F74fs	NM_152470.2	NP_689683.2	Q6ZSG1	RN165_HUMAN	ring finger protein 165	266							zinc ion binding			NS(1)|large_intestine(4)|lung(6)	11				READ - Rectum adenocarcinoma(1;0.0873)		GGTTCACCTTCCCCCACAAGT	0.542													15	40	---	---	---	---					
LILRA6	79168	broad.mit.edu	37	19	54744957	54744977	+	In_Frame_Del	DEL	CAGGACAGGGCCCTGCAGGGT	CAGGACAGGGCCCTGCAGGGT	-			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:54744957_54744977delCAGGACAGGGCCCTGCAGGGT	ENST00000440558.2	-	5	733_753	c.685_705delACCCTGCAGGGCCCTGTCCTG	c.(685-705)del	p.TLQGPVL229del	LILRA6_ENST00000270464.5_Intron|LILRA6_ENST00000245621.5_In_Frame_Del_p.TLQGPVL229del|LILRA6_ENST00000419410.2_In_Frame_Del_p.TLQGPVL229del|LILRA6_ENST00000396365.2_In_Frame_Del_p.TLQGPVL229del|LILRB3_ENST00000407860.2_Intron|LILRA6_ENST00000391735.3_3'UTR					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GCCCAGGGGCCAGGACAGGGCCCTGCAGGGTCAGGAGGGAG	0.638													8	112	---	---	---	---					
LILRB4	11006	broad.mit.edu	37	19	55178154	55178154	+	Frame_Shift_Del	DEL	C	C	-			TCGA-55-8615-01A-11D-2393-08	TCGA-55-8615-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	010ae1ac-cdd8-45e5-8441-eb0bd518fd88	7c05c2e8-8fdd-44a0-acaa-e3d93054d0de	g.chr19:55178154delC	ENST00000391736.1	+	12	1310	c.995delC	c.(994-996)gcfs	p.A332fs	LILRB4_ENST00000270452.2_Frame_Shift_Del_p.A332fs|LILRB4_ENST00000391733.3_Frame_Shift_Del_p.A333fs|LILRB4_ENST00000391734.3_Frame_Shift_Del_p.A332fs|LILRB4_ENST00000430952.2_Frame_Shift_Del_p.A332fs	NM_001278426.2|NM_001278428.2|NM_001278429.2|NM_001278430.2	NP_001265355.1|NP_001265357.1|NP_001265358.1|NP_001265359.1	Q8NHJ6	LIRB4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4	332						integral to membrane|plasma membrane	antigen binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(20)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	39				GBM - Glioblastoma multiforme(193;0.035)		GCAGGTGCTGCCGTGAAGAAC	0.607													47	161	---	---	---	---					
