Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NUTM2D	728130	broad.mit.edu	37	10	89120919	89120919	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr10:89120919C>T	ENST00000412718.1	+	2	1394	c.848C>T	c.(847-849)gCg>gTg	p.A283V	NUTM2D_ENST00000381697.2_Missense_Mutation_p.A283V					NUT family member 2D																		GACACCGAAGCGCTTTCGTGC	0.597000													22	140					0	0	1	0	0
IFNA21	3452	broad.mit.edu	37	9	21166060	21166060	+	Missense_Mutation	SNP	T	T	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr9:21166060T>A	ENST00000380225.1	-	1	599	c.552A>T	c.(550-552)agA>agT	p.R184S		NM_002175.2	NP_002166.2	P01568	IFN21_HUMAN	interferon, alpha 21	184					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)	14				GBM - Glioblastoma multiforme(5;1.93e-187)|Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		TCCTCCTTAATCTTTCTTGAA	0.383000													67	93					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38126718	38126718	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr4:38126718T>G	ENST00000261439.4	+	18	3453	c.3098T>G	c.(3097-3099)cTt>cGt	p.L1033R	TBC1D1_ENST00000508802.1_Intron|TBC1D1_ENST00000407365.1_3'UTR	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	1033						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						CTACCCAACCTTGGCTTGGTA	0.408000													21	55					0	0	1	0	0
C8A	731	broad.mit.edu	37	1	57349283	57349283	+	Missense_Mutation	SNP	T	T	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr1:57349283T>A	ENST00000361249.3	+	6	880	c.784T>A	c.(784-786)Ttg>Atg	p.L262M		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	262	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CAGCCCTTTATTGGTGGGTGT	0.403000													14	47					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5067912	5067912	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr11:5067912G>T	ENST00000380370.1	+	1	157	c.157G>T	c.(157-159)Gta>Tta	p.V53L		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	53					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTCATCAAGGTAGAACAGAC	0.517000													43	38					4.14194e-30	4.65968e-30	1	1	0
NSD1	64324	broad.mit.edu	37	5	176687001	176687001	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr5:176687001C>T	ENST00000439151.2	+	14	5023	c.4978C>T	c.(4978-4980)Cgc>Tgc	p.R1660C	NSD1_ENST00000361032.4_Missense_Mutation_p.R1557C|NSD1_ENST00000354179.4_Missense_Mutation_p.R1391C|NSD1_ENST00000347982.4_Missense_Mutation_p.R1391C	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1660					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding	p.R1660C(2)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TCGGTTGATGCGCTGTGTCCG	0.403000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			4	150					0	0	1	0	0
GLRA4	441509	broad.mit.edu	37	X	102974035	102974035	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chrX:102974035C>T	ENST00000372617.4	-	7	1303	c.883G>A	c.(883-885)Gtg>Atg	p.V295M		NM_001024452.2	NP_001019623.2	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4	295						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						ATGGTGAGCACGGTGGTGATG	0.582000													36	134					0	0	1	0	0
FEM1A	55527	broad.mit.edu	37	19	4793160	4793160	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr19:4793160G>A	ENST00000269856.3	+	1	1433	c.1294G>A	c.(1294-1296)Gcc>Acc	p.A432T	AC005523.2_ENST00000601192.1_RNA	NM_018708.2	NP_061178.1	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a (C. elegans)	432					regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	17		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		CCCCATGACCGCCAGCAGCTT	0.617000													4	130					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44921455	44921455	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr15:44921455T>G	ENST00000261866.7	-	9	1883	c.1867A>C	c.(1867-1869)Aag>Cag	p.K623Q	SPG11_ENST00000427534.2_Missense_Mutation_p.K623Q|SPG11_ENST00000558319.1_Missense_Mutation_p.K623Q|SPG11_ENST00000535302.2_Missense_Mutation_p.K623Q|SPG11_ENST00000559193.1_Missense_Mutation_p.K623Q	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	623					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		AAAAGCTCCTTTATTTGGTTG	0.398000													27	50					0	0	1	0	0
NPIPB11	728888	broad.mit.edu	37	16	29415043	29415043	+	Silent	SNP	G	G	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr16:29415043G>A	ENST00000524087.1	-	2	155	c.81C>T	c.(79-81)caC>caT	p.H27H	SNX29P2_ENST00000398878.3_lincRNA					nuclear pore complex interacting protein family, member B11									p.H27H(24)									CTGACTTTACGTGCTGCTGCA	0.577000													3	14					0	0	1	0	0
FAM71E1	112703	broad.mit.edu	37	19	50979475	50979475	+	Silent	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr19:50979475C>T	ENST00000600100.1	-	1	535	c.171G>A	c.(169-171)ccG>ccA	p.P57P	FAM71E1_ENST00000595790.1_Silent_p.P57P			Q6IPT2	F71E1_HUMAN	family with sequence similarity 71, member E1	57										breast(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		CCCCGTCCGACGGGAGCGGAC	0.662000													42	32					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42513913	42513913	+	Splice_Site	SNP	C	C	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr17:42513913C>A	ENST00000591680.1	-	4	224	c.193_splice	c.e4-1	p.G65_splice	GPATCH8_ENST00000586265.1_5'UTR|GPATCH8_ENST00000434000.1_5'UTR	NM_001002909.2	NP_001002909.1	Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	65	G-patch.					intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		ATCTGTTCTCCCTGTAACAGG	0.428000													25	10					1.16021e-09	1.20483e-09	1	1	0
EEF1B2	1933	broad.mit.edu	37	2	207025358	207025358	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr2:207025358A>G	ENST00000392222.2	+	2	502	c.127A>G	c.(127-129)Agc>Ggc	p.S43G	EEF1B2_ENST00000236957.5_Missense_Mutation_p.S43G|EEF1B2_ENST00000392221.1_Missense_Mutation_p.S43G	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	43	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.S43G(4)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						AGCCGTGTCCAGCCCACCGCC	0.468000													4	83					0	0	1	0	0
FAM27L	284123	broad.mit.edu	37	17	21825411	21825411	+	RNA	SNP	G	G	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr17:21825411G>A	ENST00000426869.3	+	0	115					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		gcagggcttcggtgtcggggc	0.622000													10	4					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51175050	51175050	+	Silent	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr16:51175050C>T	ENST00000440970.1	-	2	1223	c.792G>A	c.(790-792)ggG>ggA	p.G264G	SALL1_ENST00000541611.1_Intron|SALL1_ENST00000251020.4_Silent_p.G361G|SALL1_ENST00000566102.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	361					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CATGGGAGGCCCCAGCACTTG	0.507000													24	58					0	0	1	0	0
MIEF2	125170	broad.mit.edu	37	17	18167985	18167985	+	Silent	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr17:18167985C>T	ENST00000323019.4	+	4	1483	c.1272C>T	c.(1270-1272)agC>agT	p.S424S	SMCR7_ENST00000395706.2_Silent_p.S435S|SMCR7_ENST00000395704.4_3'UTR	NM_001144900.1|NM_139162.3	NP_001138372.1|NP_631901.2	Q96C03	SMCR7_HUMAN		424						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|lung(4)	9	all_neural(463;0.228)					TCAACCCCAGCGTGAACCTCT	0.622000													26	21					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38913145	38913145	+	Missense_Mutation	SNP	C	C	G			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr3:38913145C>G	ENST00000302328.3	-	21	3748	c.3550G>C	c.(3550-3552)Gtc>Ctc	p.V1184L	SCN11A_ENST00000444237.2_Missense_Mutation_p.V1184L|SCN11A_ENST00000456224.3_Missense_Mutation_p.V1146L|SCN11A_ENST00000450244.1_Missense_Mutation_p.V1184L	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1184					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATGAGGCAGACAAGCAAAACA	0.383000													26	21					0	0	1	0	0
RLBP1	6017	broad.mit.edu	37	15	89758399	89758399	+	Silent	SNP	G	G	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr15:89758399G>A	ENST00000268125.5	-	6	856	c.417C>T	c.(415-417)acC>acT	p.T139T		NM_000326.4	NP_000317.1	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	139	CRAL-TRIO.				response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(1)|prostate(1)|skin(1)	18	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	CAGCTTCAATGGTGCAGCGGA	0.547000													21	133					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	184001716	184001716	+	Silent	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr3:184001716C>T	ENST00000402825.3	+	8	1314	c.1314C>T	c.(1312-1314)cgC>cgT	p.R438R	ECE2_ENST00000357474.5_Silent_p.R366R|ECE2_ENST00000359140.4_Silent_p.R291R|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000404464.3_Silent_p.R320R	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	438	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACCAGCGGCGCGACGAGGAGA	0.637000													7	39					0	0	1	0	0
RLBP1	6017	broad.mit.edu	37	15	89755000	89755000	+	Missense_Mutation	SNP	G	G	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr15:89755000G>T	ENST00000268125.5	-	7	1097	c.658C>A	c.(658-660)Ctc>Atc	p.L220I		NM_000326.4	NP_000317.1	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	220	CRAL-TRIO.				response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(1)|prostate(1)|skin(1)	18	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	ATCTTCCTGAGATCTGAAGTC	0.547000													20	70					5.26018e-13	5.68099e-13	1	1	0
DEFA5	1670	broad.mit.edu	37	8	6913033	6913033	+	Missense_Mutation	SNP	T	T	G			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr8:6913033T>G	ENST00000330590.2	-	2	241	c.205A>C	c.(205-207)Acc>Ccc	p.T69P		NM_021010.1	NP_066290.1	Q01523	DEF5_HUMAN	defensin, alpha 5, Paneth cell-specific	69					defense response to bacterium|defense response to fungus|killing of cells of other organism	extracellular space				NS(1)|lung(4)|skin(1)|stomach(1)	7				COAD - Colon adenocarcinoma(149;0.0572)|READ - Rectum adenocarcinoma(644;0.121)		CAACGGCCGGTTCGGCAATAG	0.562000													4	3					0	0	1	0	0
ZMYND11	10771	broad.mit.edu	37	10	292708	292708	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr10:292708C>T	ENST00000397962.3	+	11	1381	c.953C>T	c.(952-954)gCc>gTc	p.A318V	ZMYND11_ENST00000602682.1_Missense_Mutation_p.A233V|ZMYND11_ENST00000381607.4_Missense_Mutation_p.A224V|ZMYND11_ENST00000381584.1_Missense_Mutation_p.A301V|ZMYND11_ENST00000473115.1_3'UTR|ZMYND11_ENST00000402736.1_Missense_Mutation_p.A287V|ZMYND11_ENST00000509513.2_Missense_Mutation_p.A317V|ZMYND11_ENST00000558098.2_Missense_Mutation_p.A318V|ZMYND11_ENST00000545619.1_Missense_Mutation_p.A198V|ZMYND11_ENST00000535374.1_Missense_Mutation_p.A113V|ZMYND11_ENST00000403354.1_Missense_Mutation_p.A238V|ZMYND11_ENST00000381604.4_Missense_Mutation_p.A278V|ZMYND11_ENST00000381591.1_Missense_Mutation_p.A318V|ZMYND11_ENST00000381602.4_Missense_Mutation_p.A278V|ZMYND11_ENST00000309776.4_Missense_Mutation_p.A278V|ZMYND11_ENST00000397959.3_Missense_Mutation_p.A233V			Q15326	ZMY11_HUMAN	zinc finger, MYND-type containing 11	278					cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	24		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		TTTCCTAGGGCCTGGATTCCT	0.473000													11	32					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51196725	51196725	+	Silent	SNP	G	G	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr3:51196725G>T	ENST00000266037.9	+	11	902	c.879G>T	c.(877-879)gtG>gtT	p.V293V		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	293						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TTGCCCATGTGATCCGAATAG	0.378000													17	33					7.21436e-19	7.95052e-19	1	1	0
EEF1B2	1933	broad.mit.edu	37	2	207025366	207025366	+	Silent	SNP	G	G	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr2:207025366G>A	ENST00000392222.2	+	2	510	c.135G>A	c.(133-135)ccG>ccA	p.P45P	EEF1B2_ENST00000236957.5_Silent_p.P45P|EEF1B2_ENST00000392221.1_Silent_p.P45P	NM_001959.3	NP_001950.1	P24534	EF1B_HUMAN	eukaryotic translation elongation factor 1 beta 2	45	GST C-terminal.					cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity	p.P45P(5)		breast(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(6)	16						CCAGCCCACCGCCTGCCGACT	0.448000													4	80					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42513914	42513914	+	Splice_Site	SNP	C	C	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr17:42513914C>A	ENST00000434000.1	-	5	242		c.e5-1		GPATCH8_ENST00000591680.1_Splice_Site|GPATCH8_ENST00000586265.1_Splice_Site			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8							intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TCTGTTCTCCCTGTAACAGGA	0.423000													24	10					1.12875e-08	1.12875e-08	1	1	0
PBX4	80714	broad.mit.edu	37	19	19680947	19680947	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr19:19680947C>T	ENST00000251203.8	-	4	889	c.603G>A	c.(601-603)atG>atA	p.M201I		NM_025245.2	NP_079521.1	Q9BYU1	PBX4_HUMAN	pre-B-cell leukemia homeobox 4	201							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(4)|ovary(1)|prostate(3)	9						AACGCAGGGTCATCACTGCCT	0.597000													24	17					0	0	1	0	0
PHKA2	5256	broad.mit.edu	37	X	18959758	18959758	+	Silent	SNP	T	T	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chrX:18959758T>A	ENST00000379942.4	-	8	1418	c.753A>T	c.(751-753)acA>acT	p.T251T		NM_000292.2	NP_000283.1	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	251			Missing (in GSD9A; type 2).		glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					TTTCTTTAGATGTCGACGCTC	0.413000													27	79					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168189644	168189644	+	Missense_Mutation	SNP	C	C	T	rs73802391	byFrequency	TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr5:168189644C>T	ENST00000519560.1	-	15	1929	c.1510G>A	c.(1510-1512)Gtg>Atg	p.V504M	SLIT3_ENST00000404867.3_Missense_Mutation_p.V504M|SLIT3_ENST00000332966.8_Missense_Mutation_p.V504M	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	504	LRRNT 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCGGGGCACACGAGGTCCATG	0.612000													8	227					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	44					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130412683	130412683	+	Missense_Mutation	SNP	G	G	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chrX:130412683G>A	ENST00000370904.1	-	18	2676	c.1766C>T	c.(1765-1767)aCc>aTc	p.T589I	IGSF1_ENST00000361420.3_Missense_Mutation_p.T598I|IGSF1_ENST00000370903.3_Missense_Mutation_p.T603I|IGSF1_ENST00000370910.1_Missense_Mutation_p.T589I			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	598	Ig-like C2-type 6.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						AGGAAAGTTGGTCTCTGCCCA	0.547000													39	105					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195512118	195512118	+	Silent	SNP	G	G	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr3:195512118G>A	ENST00000463781.3	-	2	6792	c.6333C>T	c.(6331-6333)acC>acT	p.T2111T	MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000475231.1_Silent_p.T2111T	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	880	EGF-like 2.				cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		CATGAAGAGCGGTGGCGTGAC	0.572000													3	3					0	0	1	0	0
BAI3	577	broad.mit.edu	37	6	70037717	70037717	+	Missense_Mutation	SNP	C	C	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr6:70037717C>A	ENST00000370598.1	+	22	3792	c.2971C>A	c.(2971-2973)Cca>Aca	p.P991T	BAI3_ENST00000238918.8_Missense_Mutation_p.P197T	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	991					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TGCAGGTTTACCAGCATTAGT	0.393000													21	41					4.35082e-09	4.43291e-09	1	1	0
NUDCD3	23386	broad.mit.edu	37	7	44524807	44524807	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr7:44524807C>T	ENST00000355451.6	-	2	548	c.269G>A	c.(268-270)aGa>aAa	p.R90K		NM_015332.3	NP_056147.2	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	90										endometrium(2)|large_intestine(1)|lung(3)|skin(1)	7						CTCTTCCTTTCTTCTGATTTT	0.473000													21	56					0	0	1	0	0
EBP	10682	broad.mit.edu	37	X	48382378	48382378	+	Silent	SNP	G	G	A			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chrX:48382378G>A	ENST00000495186.1	+	2	1042	c.219G>A	c.(217-219)ggG>ggA	p.G73G	EBP_ENST00000276096.6_3'UTR	NM_006579.2	NP_006570.1	Q15125	EBP_HUMAN	emopamil binding protein (sterol isomerase)	73					cholesterol biosynthetic process|skeletal system development	endoplasmic reticulum membrane|integral to plasma membrane	cholestenol delta-isomerase activity|drug transmembrane transporter activity|steroid delta-isomerase activity|transmembrane receptor activity			NS(1)|endometrium(2)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|stomach(1)	11						CAGTGTGTGGGTTCATTCACC	0.537000													23	80					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38126700	38126700	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr4:38126700A>G	ENST00000261439.4	+	18	3435	c.3080A>G	c.(3079-3081)aAa>aGa	p.K1027R	TBC1D1_ENST00000508802.1_Intron|TBC1D1_ENST00000407365.1_3'UTR	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	1027						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						GACTTTATAAAAAGCACGCTA	0.418000													28	67					0	0	1	0	0
SEC63	11231	broad.mit.edu	37	6	108222676	108222676	+	Missense_Mutation	SNP	C	C	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr6:108222676C>T	ENST00000369002.4	-	13	1434	c.1255G>A	c.(1255-1257)Gat>Aat	p.D419N		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	419	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		GTGTGACGATCTGATTCTTTT	0.318000													27	27					0	0	1	0	0
CSF1R	1436	broad.mit.edu	37	5	149441326	149441326	+	Nonsense_Mutation	SNP	G	G	T			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr5:149441326G>T	ENST00000286301.3	-	12	2004	c.1713C>A	c.(1711-1713)taC>taA	p.Y571*	CSF1R_ENST00000515239.1_5'UTR	NM_005211.3	NP_005202.2	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor	571					cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(38)|kidney(2)|large_intestine(6)|liver(3)|lung(23)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	93			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	ACTTCTCGTTGTAAGGCAGCT	0.552000													19	111					3.51602e-12	3.72284e-12	1	1	0
EFR3A	23167	broad.mit.edu	37	8	132982870	132982870	+	Missense_Mutation	SNP	A	A	G			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr8:132982870A>G	ENST00000254624.5	+	10	1364	c.1139A>G	c.(1138-1140)aAt>aGt	p.N380S	EFR3A_ENST00000519656.1_Missense_Mutation_p.N344S|EFR3A_ENST00000334503.4_Missense_Mutation_p.N380S	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	380						plasma membrane	binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			ATTGTGCAGAATGCTATCATC	0.368000													46	78					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1638057	1638058	+	Frame_Shift_Ins	INS	-	-	G			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr2:1638057_1638058insG	ENST00000252804.4	-	23	4408_4409	c.4358_4359insC	c.(4357-4359)cgcfs	p.R1453fs		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1453	VWFC.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CACAGGTGGCAGGGGGGCAAGC	0.624													7	10	---	---	---	---					
FN1	2335	broad.mit.edu	37	2	216226286	216226286	+	Frame_Shift_Del	DEL	G	G	-	rs146924311	by1000genomes	TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr2:216226286delG	ENST00000354785.4	-	46	7795	c.7426delC	c.(7426-7428)gafs	p.R2476fs	FN1_ENST00000357009.2_3'UTR|FN1_ENST00000357867.4_Frame_Shift_Del_p.R2175fs|FN1_ENST00000356005.4_Frame_Shift_Del_p.R2295fs|FN1_ENST00000345488.5_Frame_Shift_Del_p.R2183fs|FN1_ENST00000443816.1_Frame_Shift_Del_p.R2264fs|FN1_ENST00000346544.3_Frame_Shift_Del_p.R2210fs|FN1_ENST00000421182.1_Frame_Shift_Del_p.R2239fs|FN1_ENST00000359671.1_Frame_Shift_Del_p.R2385fs|FN1_ENST00000336916.4_Frame_Shift_Del_p.R2354fs|FN1_ENST00000432072.2_Frame_Shift_Del_p.R2266fs|FN1_ENST00000323926.6_Frame_Shift_Del_p.R2445fs|FN1_ENST00000446046.1_Frame_Shift_Del_p.R2329fs			P02751	FINC_HUMAN	fibronectin 1	2385					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding		FN1/ALK(2)	NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(7)|endometrium(9)|kidney(8)|large_intestine(33)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	109		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ATTTACTCTCGGGAATCTTCT	0.408													33	129	---	---	---	---					
IQCF5	389124	broad.mit.edu	37	3	51908064	51908064	+	Frame_Shift_Del	DEL	C	C	-			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr3:51908064delC	ENST00000446461.1	-	2	184	c.132delG	c.(130-132)tgfs	p.W45fs	IQCF5-AS1_ENST00000440723.1_RNA	NM_001145059.1	NP_001138531.1	A8MTL0	IQCF5_HUMAN	IQ motif containing F5	45										kidney(1)	1						CCTGCCTCCACCAGCACTGAA	0.602													2	4	---	---	---	---					
POMZP3	22932	broad.mit.edu	37	7	76255354	76255356	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr7:76255354_76255356delTCC	ENST00000310842.4	-	2	710_712	c.26_28delGGA	c.(25-30)atc>a	p.RI9del	UPK3B_ENST00000419923.2_Intron|AC004980.7_ENST00000418663.1_RNA|POMZP3_ENST00000275569.4_In_Frame_Del_p.RI9del|UPK3B_ENST00000443097.2_Intron	NM_012230.3	NP_036362.3	Q6PJE2	POZP3_HUMAN	POM121 and ZP3 fusion	9										kidney(3)|lung(2)	5		Myeloproliferative disorder(862;0.204)				GGAGGGGCGATCCTCAGAGTCAC	0.507													12	58	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49434685	49434685	+	Frame_Shift_Del	DEL	C	C	-			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr12:49434685delC	ENST00000301067.7	-	31	6867	c.6868delG	c.(6868-6870)aafs	p.E2291fs		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		CCAAGCTCTTCCTTCTTCACC	0.622													25	37	---	---	---	---					
LA16c-306E5.3	0	broad.mit.edu	37	16	3546140	3546141	+	RNA	INS	-	-	A	rs74546027		TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr16:3546140_3546141insA	ENST00000574423.2	+	0	111																											gactccgtctcaaaaaaaaaaa	0.559													4	3	---	---	---	---					
E2F4	1874	broad.mit.edu	37	16	67226952	67226952	+	Frame_Shift_Del	DEL	A	A	-			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr16:67226952delA	ENST00000379378.3	+	3	345	c.286delA	c.(286-288)aafs	p.K96fs	E2F4_ENST00000564718.1_3'UTR	NM_001950.3	NP_001941.2	Q16254	E2F4_HUMAN	E2F transcription factor 4, p107/p130-binding	96	Dimerization (Potential).				G1 phase of mitotic cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(4)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)	11		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000697)|Epithelial(162;0.00303)|all cancers(182;0.0325)		GATTGCTGACAAACTGATTGA	0.612													2	4	---	---	---	---					
PAFAH1B1	5048	broad.mit.edu	37	17	2569368	2569368	+	Frame_Shift_Del	DEL	T	T	-			TCGA-62-8397-01A-11D-2323-08	TCGA-62-8397-10A-01D-2323-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4211c6c7-de22-4a5e-ac2a-f5fb7e448692	b65e341c-8a4d-457c-a2e9-c829a3f6a677	g.chr17:2569368delT	ENST00000397195.5	+	4	627	c.176delT	c.(175-177)atfs	p.I59fs		NM_000430.3	NP_000421.1	P43034	LIS1_HUMAN	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)	59	Interaction with NDE1 (By similarity).|Interaction with NDEL1 (By similarity).				acrosome assembly|actin cytoskeleton organization|adult locomotory behavior|brain morphogenesis|corpus callosum morphogenesis|establishment of mitotic spindle orientation|G2/M transition of mitotic cell cycle|hippocampus development|layer formation in cerebral cortex|learning or memory|lipid catabolic process|microtubule organizing center organization|mitotic prometaphase|neuroblast proliferation|neuromuscular process controlling balance|neuron migration|platelet activating factor metabolic process|regulation of Rho GTPase activity|retrograde axon cargo transport|synaptic transmission|vesicle transport along microtubule	astral microtubule|cell cortex|centrosome|cytosol|kinetochore|motile primary cilium|nuclear membrane|perinuclear region of cytoplasm	dynactin binding|heparin binding|microtubule binding|phospholipase binding|phosphoprotein binding|protein homodimerization activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(1)|skin(1)	11						ACATCTGTTATTAGATTACAA	0.224													2	4	---	---	---	---					
