Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FDXR	2232	broad.mit.edu	37	17	72862631	72862631	+	Silent	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr17:72862631G>A	ENST00000455107.2	-	5	614	c.198C>T	c.(196-198)aaC>aaT	p.N66N	FDXR_ENST00000544854.1_Silent_p.N58N|FDXR_ENST00000442102.2_Silent_p.N153N|FDXR_ENST00000293195.5_Silent_p.N110N|FDXR_ENST00000581969.1_5'UTR|FDXR_ENST00000420580.2_Intron|FDXR_ENST00000581530.1_Silent_p.N110N|FDXR_ENST00000583917.1_Silent_p.N111N|FDXR_ENST00000413947.2_Silent_p.N141N|FDXR_ENST00000582944.1_Silent_p.N102N			P22570	ADRO_HUMAN	ferredoxin reductase	110					cholesterol metabolic process|electron transport chain|steroid biosynthetic process|transport	mitochondrial matrix	ferredoxin-NADP+ reductase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16	all_lung(278;0.172)|Lung NSC(278;0.207)					CCACCTCCACGTTGCCCCAGA	0.652000													12	33					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203677	140203677	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr5:140203677C>G	ENST00000529859.1	+	1	2317	c.2317C>G	c.(2317-2319)Cca>Gca	p.P773A	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.P773A|PCDHA5_ENST00000378126.3_Missense_Mutation_p.P773A|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCCTTCAGTCCAAGCCTTCC	0.507000													13	52					0	0	1	0	0
CHST1	8534	broad.mit.edu	37	11	45671564	45671564	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr11:45671564C>T	ENST00000308064.2	-	4	1580	c.910G>A	c.(910-912)Gac>Aac	p.D304N		NM_003654.5	NP_003645.1	O43916	CHST1_HUMAN	carbohydrate (keratan sulfate Gal-6) sulfotransferase 1	304					galactose metabolic process|inflammatory response|keratan sulfate metabolic process	Golgi membrane|integral to membrane	keratan sulfotransferase activity			breast(1)|endometrium(3)|large_intestine(10)|lung(17)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(35;3e-06)|BRCA - Breast invasive adenocarcinoma(625;0.0781)		CGAGCCAGGTCCTCGTAGCGC	0.632000													41	113					0	0	1	0	0
PPAP2A	8611	broad.mit.edu	37	5	54771207	54771207	+	Missense_Mutation	SNP	A	A	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr5:54771207A>G	ENST00000307259.8	-	2	550	c.130T>C	c.(130-132)Tcc>Ccc	p.S44P	PPAP2A_ENST00000264775.5_Intron|PPAP2A_ENST00000515132.1_Intron	NM_003711.2	NP_003702.2	O14494	LPP1_HUMAN	phosphatidic acid phosphatase type 2A	44					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|androgen receptor signaling pathway|germ cell migration|negative regulation of cell proliferation|phospholipid dephosphorylation|regulation of lipid metabolic process|sphingolipid metabolic process	integral to plasma membrane|membrane fraction	phosphatidate phosphatase activity|sphingosine-1-phosphate phosphatase activity			breast(2)|endometrium(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	9		Lung NSC(810;4.08e-05)|Prostate(74;0.0181)|Breast(144;0.0544)				TACTTGATGGACTCATCATTA	0.368000													5	20					0	0	1	0	0
RABL5	64792	broad.mit.edu	37	7	100962287	100962287	+	Silent	SNP	A	A	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr7:100962287A>G	ENST00000315322.4	-	2	159	c.66T>C	c.(64-66)ttT>ttC	p.F22F	RABL5_ENST00000495166.1_Intron|RABL5_ENST00000437644.2_Silent_p.F22F|RABL5_ENST00000517481.1_5'UTR|RABL5_ENST00000498704.2_Intron	NM_022777.2	NP_073614.1	Q9H7X7	RABL5_HUMAN	RAB, member RAS oncogene family-like 5	22							GTP binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	7	Lung NSC(181;0.215)					ATTCTGTCAGAAAGTTGGCCA	0.463000													17	50					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44219921	44219921	+	Missense_Mutation	SNP	A	A	G	rs139414975		TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr6:44219921A>G	ENST00000371554.1	+	10	1862	c.1648A>G	c.(1648-1650)Aag>Gag	p.K550E	HSP90AB1_ENST00000353801.3_Missense_Mutation_p.K550E|HSP90AB1_ENST00000371646.5_Missense_Mutation_p.K550E			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	550					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TGAGGAGGAGAAGAAGAAGAT	0.483000													12	32					0	0	1	0	0
COL12A1	1303	broad.mit.edu	37	6	75838065	75838065	+	Missense_Mutation	SNP	A	A	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr6:75838065A>G	ENST00000322507.8	-	38	6596	c.6287T>C	c.(6286-6288)aTt>aCt	p.I2096T	COL12A1_ENST00000483888.2_Missense_Mutation_p.I2096T|COL12A1_ENST00000416123.2_Missense_Mutation_p.I2096T|COL12A1_ENST00000345356.6_Missense_Mutation_p.I932T	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2096	Fibronectin type-III 16.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						ATAAACAGCAATAACAGTAAT	0.378000													14	20					0	0	1	0	0
EIF2A	83939	broad.mit.edu	37	3	150285753	150285753	+	Missense_Mutation	SNP	A	A	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr3:150285753A>C	ENST00000460851.1	+	8	723	c.614A>C	c.(613-615)aAc>aCc	p.N205T	EIF2A_ENST00000383043.3_Intron|EIF2A_ENST00000406576.3_Missense_Mutation_p.N144T|SERP1_ENST00000479209.1_Intron|EIF2A_ENST00000273435.5_Missense_Mutation_p.N200T|SERP1_ENST00000490945.1_Intron|EIF2A_ENST00000487799.1_Missense_Mutation_p.N180T			Q9BY44	EIF2A_HUMAN	eukaryotic translation initiation factor 2A, 65kDa	205					regulation of translation|ribosome assembly	eukaryotic translation initiation factor 2 complex	ribosome binding|translation initiation factor activity|tRNA binding			cervix(1)|endometrium(2)|kidney(1)|lung(3)	7		Melanoma(1037;0.0575)	LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			CAGTACCCCAACTTTGCTGGA	0.323000													5	29					0	0	1	0	0
MCOLN1	57192	broad.mit.edu	37	19	7594575	7594575	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr19:7594575G>A	ENST00000264079.6	+	11	1461	c.1336G>A	c.(1336-1338)Gtg>Atg	p.V446M		NM_020533.2	NP_065394.1	Q9GZU1	MCLN1_HUMAN	mucolipin 1	446			V -> L (in MLIV; does not affect channel activity; affects channel inhibition by low pH).		calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TGGCTGGATCGTGCTGGGGCC	0.582000													48	136					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117809951	117809951	+	Missense_Mutation	SNP	A	A	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chrX:117809951A>T	ENST00000276204.6	+	47	5326	c.5252A>T	c.(5251-5253)gAa>gTa	p.E1751V	DOCK11_ENST00000276202.7_Missense_Mutation_p.E1751V			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1751	DHR-2.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						AAAATTCTGGAAGTTATGCAT	0.294000													3	13					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2115837	2115837	+	Missense_Mutation	SNP	G	G	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr9:2115837G>T	ENST00000382203.1	+	25	3681	c.3472G>T	c.(3472-3474)Gac>Tac	p.D1158Y	SMARCA2_ENST00000357248.2_Missense_Mutation_p.D1158Y|SMARCA2_ENST00000349721.2_Missense_Mutation_p.D1158Y|SMARCA2_ENST00000382194.1_Missense_Mutation_p.D1158Y			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	1158	Helicase C-terminal.				chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GCAGGCCCAAGACCGAGCTCA	0.572000													4	8					0.00909568	0.00919674	1	1	0
SLC47A1	55244	broad.mit.edu	37	17	19470499	19470499	+	Missense_Mutation	SNP	A	A	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr17:19470499A>T	ENST00000270570.4	+	14	1353	c.1267A>T	c.(1267-1269)Atc>Ttc	p.I423F	SLC47A1_ENST00000436810.2_Missense_Mutation_p.I400F|RP11-1113L8.1_ENST00000574267.1_RNA|SLC47A1_ENST00000575023.1_Intron|SLC47A1_ENST00000395585.1_Missense_Mutation_p.I423F|SLC47A1_ENST00000571335.1_Missense_Mutation_p.I228F|SLC47A1_ENST00000457293.1_Missense_Mutation_p.I423F	NM_018242.2	NP_060712.2	Q96FL8	S47A1_HUMAN	solute carrier family 47 (multidrug and toxin extrusion), member 1	423						integral to membrane|plasma membrane	drug:hydrogen antiporter activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(5)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	23	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					TGGCCTCCCCATCGGGATCGC	0.552000													39	171					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130898840	130898840	+	Nonsense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr12:130898840G>A	ENST00000261655.4	-	14	2645	c.2482C>T	c.(2482-2484)Cga>Tga	p.R828*		NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	828						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		AGGCGGTCTCGCCCGTAATCG	0.567000													24	76					0	0	1	0	0
MAP1A	4130	broad.mit.edu	37	15	43821544	43821544	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr15:43821544C>T	ENST00000382031.1	+	5	8618	c.8587C>T	c.(8587-8589)Cgg>Tgg	p.R2863W	MAP1A_ENST00000300231.5_Missense_Mutation_p.R2625W|MAP1A_ENST00000399453.1_Missense_Mutation_p.R2625W			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	2625						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	TCTGGATCTTCGGGGAAAACG	0.652000													30	69					0	0	1	0	0
IRX6	79190	broad.mit.edu	37	16	55360339	55360339	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr16:55360339C>T	ENST00000290552.7	+	2	1469	c.137C>T	c.(136-138)gCt>gTt	p.A46V	RP11-26L20.3_ENST00000558730.2_RNA|IRX6_ENST00000558315.1_3'UTR	NM_024335.2	NP_077311.2	P78412	IRX6_HUMAN	iroquois homeobox 6	46						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(2)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	33						CCAGCGCCCGCTCTCTGCTGC	0.637000													17	56					0	0	1	0	0
LCA5L	150082	broad.mit.edu	37	21	40795120	40795120	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr21:40795120C>T	ENST00000358268.2	-	5	1147	c.619G>A	c.(619-621)Gta>Ata	p.V207I	LCA5L_ENST00000485895.2_Missense_Mutation_p.V207I|LCA5L_ENST00000380671.2_Missense_Mutation_p.V207I|LCA5L_ENST00000288350.3_Missense_Mutation_p.V207I			O95447	LCA5L_HUMAN	Leber congenital amaurosis 5-like	207										breast(1)|cervix(1)|endometrium(3)|large_intestine(8)|lung(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	24		Prostate(19;1.2e-06)				AAATTTTTTACTTCATTCTGA	0.323000													3	25					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522786	95522786	+	RNA	SNP	T	T	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:95522786T>C	ENST00000432432.2	-	0	241					NR_040113.1													p.K44K(1)									CGGCGTCGCCTTTGACAGCTG	0.687000													6	86					0	0	1	0	0
RAB6C-AS1	100131320	broad.mit.edu	37	2	130725780	130725780	+	RNA	SNP	C	C	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:130725780C>A	ENST00000412425.1	-	0	838					NR_036537.1																						CAAACACACACAAAAAAGATG	0.423000													5	21					1.23904e-05	1.29601e-05	1	1	0
DOCK8	81704	broad.mit.edu	37	9	379811	379811	+	Silent	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr9:379811C>T	ENST00000432829.2	+	21	2593	c.2277C>T	c.(2275-2277)atC>atT	p.I759I	DOCK8_ENST00000382331.1_Silent_p.I129I|DOCK8_ENST00000382329.1_Silent_p.I294I|DOCK8_ENST00000453981.1_Silent_p.I827I|DOCK8_ENST00000469391.1_Silent_p.I759I	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	827					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TGGTGGCCATCGCCAACAGTC	0.577000													8	34					0	0	1	0	0
CUL3	8452	broad.mit.edu	37	2	225339003	225339003	+	Nonsense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:225339003G>A	ENST00000264414.4	-	16	2604	c.2266C>T	c.(2266-2268)Cga>Tga	p.R756*	CUL3_ENST00000344951.4_Nonsense_Mutation_p.R690*|CUL3_ENST00000409777.1_Nonsense_Mutation_p.R732*|CUL3_ENST00000409096.1_Nonsense_Mutation_p.R732*	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	756					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		TCAGGTGTTCGTGCCAAATAT	0.383000													3	24					0	0	1	0	0
ACTC1	70	broad.mit.edu	37	15	35086889	35086889	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr15:35086889G>A	ENST00000290378.4	-	2	776	c.121C>T	c.(121-123)Cgg>Tgg	p.R41W	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	41					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding	p.R41W(1)		central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		ACCTGGTGCCGCGGGCGGCCC	0.672000													26	53					0	0	1	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77043679	77043679	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr17:77043679G>C	ENST00000339142.2	+	5	910	c.355G>C	c.(355-357)Gca>Cca	p.A119P	C1QTNF1_ENST00000578229.1_Missense_Mutation_p.A37P|C1QTNF1_ENST00000311661.4_Missense_Mutation_p.A37P|C1QTNF1_ENST00000354124.3_Missense_Mutation_p.A129P|C1QTNF1_ENST00000579760.1_Missense_Mutation_p.A119P|C1QTNF1_ENST00000583904.1_Missense_Mutation_p.A119P|C1QTNF1_ENST00000581774.1_Missense_Mutation_p.A119P|C1QTNF1_ENST00000582625.1_3'UTR|C1QTNF1_ENST00000580474.1_Missense_Mutation_p.A119P|C1QTNF1_ENST00000580454.1_Missense_Mutation_p.A119P|C1QTNF1_ENST00000392445.2_Missense_Mutation_p.A119P	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	119	Collagen-like.					collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			AACAGGCTCAGCAGGGGCCAG	0.622000													24	98					0	0	1	0	0
CCDC27	148870	broad.mit.edu	37	1	3673432	3673432	+	Missense_Mutation	SNP	A	A	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr1:3673432A>T	ENST00000294600.2	+	4	773	c.689A>T	c.(688-690)tAc>tTc	p.Y230F		NM_152492.2	NP_689705.2	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	230										breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(2)|lung(17)|prostate(1)|skin(2)|urinary_tract(2)	36	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		ATGCCCTGGTACCTCTCAGTC	0.602000													8	20					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57328069	57328069	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr19:57328069G>A	ENST00000326441.9	-	10	2104	c.1741C>T	c.(1741-1743)Cac>Tac	p.H581Y	ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.H455Y|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.H457Y|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000601070.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.H581Y	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	581					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATTTTCTGGTGCTCAATCAGG	0.483000													15	30					0	0	1	0	0
KCNG2	26251	broad.mit.edu	37	18	77624226	77624226	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr18:77624226G>A	ENST00000316249.3	+	1	559	c.559G>A	c.(559-561)Gtg>Atg	p.V187M		NM_012283.1	NP_036415.1	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G, member 2	187					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity			breast(2)|endometrium(4)|lung(7)|skin(1)|upper_aerodigestive_tract(4)	18		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		CGTGTCCTTCGTGGCCGTCAC	0.776000													7	38					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236997	140236997	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr5:140236997C>T	ENST00000307360.5	+	1	1364	c.1364C>T	c.(1363-1365)gCg>gTg	p.A455V	PCDHA9_ENST00000532602.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.A455V|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGCGTTCGCGCAGTCCGAG	0.687000													68	219					0	0	1	0	0
SETDB1	9869	broad.mit.edu	37	1	150933236	150933236	+	Nonsense_Mutation	SNP	G	G	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr1:150933236G>T	ENST00000271640.5	+	16	2888	c.2698G>T	c.(2698-2700)Gag>Tag	p.E900*	SETDB1_ENST00000459773.1_3'UTR|SETDB1_ENST00000368969.4_Nonsense_Mutation_p.E900*	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	900	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGACCCTGAAGAGTCCAATGA	0.527000													36	64					9.04072e-19	1.01569e-18	1	1	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				7	35					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55193506	55193506	+	Silent	SNP	G	G	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr17:55193506G>T	ENST00000337714.3	+	7	2549	c.2316G>T	c.(2314-2316)ggG>ggT	p.G772G	AKAP1_ENST00000571629.1_Silent_p.G772G|AKAP1_ENST00000539273.1_Silent_p.G772G|AKAP1_ENST00000572557.1_Silent_p.G772G	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	772	Tudor.				blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					GTGCGGACGGGGCCTGGTGGC	0.632000													18	57					9.16793e-09	1.00516e-08	1	1	0
ZEB1	6935	broad.mit.edu	37	10	31815754	31815754	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr10:31815754G>A	ENST00000446923.2	+	9	3280	c.2889G>A	c.(2887-2889)atG>atA	p.M963I	ZEB1_ENST00000320985.10_Missense_Mutation_p.M979I|ZEB1_ENST00000560721.2_Missense_Mutation_p.M959I|ZEB1_ENST00000361642.5_Missense_Mutation_p.M980I|ZEB1_ENST00000542815.3_Missense_Mutation_p.M912I	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	979					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				CTCAACACATGAATCATCGCT	0.468000													11	27					0	0	1	0	0
POTEM	641455	broad.mit.edu	37	14	20010235	20010235	+	Missense_Mutation	SNP	A	A	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr14:20010235A>G	ENST00000551509.1	-	5	974	c.923T>C	c.(922-924)gTt>gCt	p.V308A	RP11-244H18.1_ENST00000547584.1_lincRNA	NM_001145442.1	NP_001138914.1	A6NI47	POTEM_HUMAN	POTE ankyrin domain family, member M	308										endometrium(4)|kidney(1)|lung(4)	9						AAGTATGAGAACAGTTCTAAA	0.368000													3	33					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368632	86368632	+	Missense_Mutation	SNP	T	T	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr13:86368632T>A	ENST00000400286.2	-	2	2610	c.2012A>T	c.(2011-2013)gAa>gTa	p.E671V		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	671						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		AGAGGGTCTTTCAGTAGTGTG	0.438000													25	70					0	0	1	0	0
GPR65	8477	broad.mit.edu	37	14	88477377	88477377	+	Silent	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr14:88477377C>T	ENST00000267549.3	+	2	744	c.186C>T	c.(184-186)ctC>ctT	p.L62L	RP11-300J18.2_ENST00000554433.1_RNA	NM_003608.3	NP_003599.2	Q8IYL9	PSYR_HUMAN	G protein-coupled receptor 65	62					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						CAGATTTACTCTATGCATTAA	0.398000													30	75					0	0	1	0	0
SLC12A2	6558	broad.mit.edu	37	5	127483420	127483420	+	Splice_Site	SNP	A	A	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr5:127483420A>G	ENST00000262461.2	+	11	2069	c.1881_splice	c.e11+1	p.Q627_splice	SLC12A2_ENST00000343225.4_Splice_Site_p.Q627_splice	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	627					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	AAAATATTTCAGGTAAGTGTT	0.328000													10	24					0	0	1	0	0
PUS7L	83448	broad.mit.edu	37	12	44130210	44130210	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr12:44130210C>T	ENST00000416848.2	-	7	2187	c.1699G>A	c.(1699-1701)Gat>Aat	p.D567N	PUS7L_ENST00000551923.1_Missense_Mutation_p.D567N|PUS7L_ENST00000344862.5_Missense_Mutation_p.D567N|PUS7L_ENST00000431332.3_Missense_Mutation_p.D254N	NM_001098615.1|NM_001271826.1	NP_001092085.1|NP_001258755.1	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S. cerevisiae)-like	567	TRUD.				pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(15)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TTCTCGTCATCAATGTCTTCA	0.368000													13	61					0	0	1	0	0
NUP153	9972	broad.mit.edu	37	6	17629177	17629177	+	Missense_Mutation	SNP	C	C	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr6:17629177C>A	ENST00000262077.2	-	18	3252	c.3253G>T	c.(3253-3255)Ggc>Tgc	p.G1085C	NUP153_ENST00000537253.1_Missense_Mutation_p.G1116C	NM_005124.2	NP_005115.2	P49790	NU153_HUMAN	nucleoporin 153kDa	1085					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			NS(2)|breast(6)|endometrium(4)|kidney(3)|large_intestine(7)|lung(23)|ovary(3)|skin(3)|urinary_tract(2)	53	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TCCACGTTGCCAAAAGAGAAT	0.458000													13	66					5.50884e-06	5.8977e-06	1	1	0
KIAA0355	9710	broad.mit.edu	37	19	34832983	34832983	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr19:34832983C>T	ENST00000299505.6	+	10	3017	c.2144C>T	c.(2143-2145)cCg>cTg	p.P715L		NM_014686.3	NP_055501.2	O15063	K0355_HUMAN	KIAA0355	715										breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	41	Esophageal squamous(110;0.162)					ACACCCCAGCCGGGACTGGCA	0.647000													37	160					0	0	1	0	0
SGCZ	137868	broad.mit.edu	37	8	13948147	13948147	+	Splice_Site	SNP	C	C	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr8:13948147C>A	ENST00000382080.1	-	8	1460		c.e8-1		SGCZ_ENST00000421524.2_Splice_Site	NM_139167.2	NP_631906.2	Q96LD1	SGCZ_HUMAN	sarcoglycan, zeta						cytoskeleton organization	cytoplasm|cytoskeleton|integral to membrane|sarcolemma				NS(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(14)|lung(15)|ovary(2)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	47				all cancers(2;0.000643)|Colorectal(111;0.00674)|COAD - Colon adenocarcinoma(73;0.0193)|GBM - Glioblastoma multiforme(2;0.026)		TTAAAAATATCTATGGGAAAA	0.388000													9	28					0.00448238	0.00458311	1	1	0
CNTNAP5	129684	broad.mit.edu	37	2	124999953	124999953	+	Missense_Mutation	SNP	C	C	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:124999953C>G	ENST00000431078.1	+	3	728	c.364C>G	c.(364-366)Caa>Gaa	p.Q122E		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	122	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		ACAGTACAAACAAGAAGACAG	0.448000													3	16					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2913354	2913354	+	Silent	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr18:2913354C>T	ENST00000254528.3	+	8	3273	c.3114C>T	c.(3112-3114)taC>taT	p.Y1038Y	EMILIN2_ENST00000308080.5_3'UTR	NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	1038	C1q.				cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		ATGAAATGTACTCCACATTTA	0.498000													4	63					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62293120	62293120	+	Silent	SNP	A	A	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr1:62293120A>G	ENST00000371158.2	+	16	1959	c.1845A>G	c.(1843-1845)aaA>aaG	p.K615K	INADL_ENST00000316485.6_Silent_p.K615K	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	615	PDZ 4.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TTTATGGAAAATCTCGCCGAG	0.423000													40	115					0	0	1	0	0
DDX42	11325	broad.mit.edu	37	17	61885097	61885097	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr17:61885097C>T	ENST00000578681.1	+	10	1461	c.860C>T	c.(859-861)gCa>gTa	p.A287V	DDX42_ENST00000583590.1_Missense_Mutation_p.A287V|DDX42_ENST00000457800.2_Missense_Mutation_p.A287V|DDX42_ENST00000389924.2_Missense_Mutation_p.A287V|DDX42_ENST00000359353.5_Missense_Mutation_p.A168V	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	287	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						GTGCCTGTGGCATTAAGTGGT	0.393000													24	74					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058330	11058330	+	RNA	SNP	G	G	A	rs138162498		TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr21:11058330G>A	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATCGCTGAAAGGGGTAAAGGA	0.378000													6	110					0	0	1	0	0
RSF1	51773	broad.mit.edu	37	11	77378137	77378137	+	Missense_Mutation	SNP	A	A	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr11:77378137A>C	ENST00000308488.6	-	16	4453	c.4151T>G	c.(4150-4152)aTt>aGt	p.I1384S	RSF1_ENST00000480887.1_Missense_Mutation_p.I1132S|RSF1_ENST00000360355.2_Missense_Mutation_p.I1353S			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	1384					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			AGGCTTGCCAATCAAGTTCTC	0.522000													28	89					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29633900	29633900	+	Missense_Mutation	SNP	A	A	G	rs60081496	by1000genomes	TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr20:29633900A>G	ENST00000278882.3	+	9	919	c.539A>G	c.(538-540)gAa>gGa	p.E180G	FRG1B_ENST00000358464.4_Missense_Mutation_p.E180G														p.E180G(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAAACAAGAGAACCAAATTGA	0.264000													4	23					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110466981	110466981	+	Silent	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr8:110466981C>T	ENST00000378402.5	+	45	6878	c.6774C>T	c.(6772-6774)caC>caT	p.H2258H		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2258	G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATTCCAACACAAGGCTGTCA	0.468000										HNSCC(38;0.096)			18	43					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													7	89					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													3	28					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62196238	62196238	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr20:62196238G>C	ENST00000467148.1	-	8	4006	c.3937C>G	c.(3937-3939)Cag>Gag	p.Q1313E	HELZ2_ENST00000427522.2_Missense_Mutation_p.Q744E	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		ATGGTGGCCTGGTCCGACGGG	0.672000													21	63					0	0	1	0	0
UBA3	9039	broad.mit.edu	37	3	69120701	69120701	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr3:69120701C>T	ENST00000361055.4	-	5	386	c.332G>A	c.(331-333)aGg>aAg	p.R111K	UBA3_ENST00000540295.1_Intron|UBA3_ENST00000349511.4_Missense_Mutation_p.R97K|UBA3_ENST00000415609.2_Missense_Mutation_p.R70K	NM_003968.3	NP_003959.3	Q8TBC4	UBA3_HUMAN	ubiquitin-like modifier activating enzyme 3	111					protein neddylation|proteolysis	nucleus	acid-amino acid ligase activity|ATP binding|protein heterodimerization activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.98e-05)|Epithelial(33;0.000363)|LUSC - Lung squamous cell carcinoma(21;0.012)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.206)|Kidney(39;0.241)		TAAAAACTGCCTATTTAGATT	0.289000													4	10					0	0	1	0	0
CMTR1	23070	broad.mit.edu	37	6	37414095	37414095	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr6:37414095G>A	ENST00000373451.4	+	4	478	c.314G>A	c.(313-315)gGa>gAa	p.G105E		NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		105	G-patch.				mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						GAAGGTGAAGGATTGGGTAAA	0.493000													48	147					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52813575	52813575	+	Missense_Mutation	SNP	A	A	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr3:52813575A>G	ENST00000273283.2	+	5	562	c.538A>G	c.(538-540)Aaa>Gaa	p.K180E	ITIH1_ENST00000540715.1_Missense_Mutation_p.K38E|ITIH1_ENST00000542827.1_Missense_Mutation_p.K180E	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	180					hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		AATTGTCATCAAAGTCAAGCC	0.532000													21	80					0	0	1	0	0
WDR92	116143	broad.mit.edu	37	2	68358560	68358560	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:68358560C>T	ENST00000295121.6	-	8	1000	c.884G>A	c.(883-885)cGg>cAg	p.R295Q	WDR92_ENST00000492039.2_5'UTR	NM_138458.3	NP_612467.1	Q96MX6	WDR92_HUMAN	WD repeat domain 92	295					apoptosis|histone lysine methylation		methylated histone residue binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|stomach(1)	12						TTTCTTTGACCGCTGAATAGG	0.388000													19	59					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40258684	40258684	+	Splice_Site	SNP	C	C	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr12:40258684C>A	ENST00000280871.4	-	6	1249	c.1198_splice	c.e6-1	p.G400_splice		NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	400						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				TACGGTGGTACCTTAAAAAAA	0.373000										HNSCC(50;0.14)			14	37					2.32078e-09	2.5755e-09	1	1	0
LCMT2	9836	broad.mit.edu	37	15	43621188	43621188	+	Silent	SNP	A	A	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr15:43621188A>C	ENST00000305641.5	-	1	1615	c.1500T>G	c.(1498-1500)ggT>ggG	p.G500G	LCMT2_ENST00000544735.1_Silent_p.G79G|LCMT2_ENST00000567039.1_3'UTR	NM_014793.4	NP_055608.2	O60294	LCMT2_HUMAN	leucine carboxyl methyltransferase 2	500					tRNA processing		methyltransferase activity|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|liver(1)|lung(9)|skin(1)|urinary_tract(1)	20		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.1e-07)	L-Leucine(DB00149)	CCACGCTTCGACCCCCATACA	0.502000													25	88					0	0	1	0	0
NCALD	83988	broad.mit.edu	37	8	102705020	102705020	+	Splice_Site	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr8:102705020G>A	ENST00000395923.1	-	5	942	c.484_splice	c.e5+1	p.D161_splice	NCALD_ENST00000522951.1_Splice_Site_p.D161_splice|NCALD_ENST00000311028.3_Splice_Site_p.D161_splice|NCALD_ENST00000519508.2_Splice_Site_p.D161_splice|NCALD_ENST00000521599.1_Splice_Site_p.D161_splice|NCALD_ENST00000220931.6_Splice_Site_p.D161_splice	NM_001040627.1|NM_001040628.1|NM_001040629.1|NM_001040630.1	NP_001035717.1|NP_001035718.1|NP_001035719.1|NP_001035720.1	P61601	NCALD_HUMAN	neurocalcin delta	161	EF-hand 4.				synaptic transmission|vesicle-mediated transport	clathrin coat of trans-Golgi network vesicle|cytosol	actin binding|calcium ion binding|clathrin binding|tubulin binding			endometrium(1)|large_intestine(2)|lung(4)|prostate(1)	8	all_cancers(14;8.94e-08)|all_epithelial(15;7.03e-10)|Lung NSC(17;1.36e-05)|all_lung(17;2.7e-05)		all cancers(13;1.09e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000699)			GCCTCCTACCGTCTCTATTGG	0.512000													12	38					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158735662	158735662	+	Missense_Mutation	SNP	C	C	T	rs150263738	byFrequency	TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr1:158735662C>T	ENST00000335094.2	-	1	830	c.811G>A	c.(811-813)Gac>Aac	p.D271N		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					AGGGCCTGGTCATAGTCCAGT	0.532000													33	144					0	0	1	0	0
ABCF3	55324	broad.mit.edu	37	3	183910606	183910606	+	Missense_Mutation	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr3:183910606G>A	ENST00000429586.2	+	18	1857	c.1672G>A	c.(1672-1674)Ggc>Agc	p.G558S	EIF2B5_ENST00000444495.1_Intron|ABCF3_ENST00000292808.5_Missense_Mutation_p.G552S	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	558	ABC transporter 2.						ATP binding|ATPase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TCTGAAGATTGGCTATTTCAG	0.542000													10	42					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51751972	51751972	+	Silent	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr6:51751972C>T	ENST00000371117.3	-	44	7343	c.7068G>A	c.(7066-7068)ccG>ccA	p.P2356P	PKHD1_ENST00000340994.4_Silent_p.P2356P	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2356					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity	p.P2356P(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGGAAAGAAGCGGAGCTTGTG	0.388000													16	37					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19505624	19505624	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr1:19505624G>C	ENST00000375267.2	-	18	2278	c.2275C>G	c.(2275-2277)Cgc>Ggc	p.R759G	UBR4_ENST00000375254.3_Missense_Mutation_p.R759G|UBR4_ENST00000375217.2_Missense_Mutation_p.R759G|UBR4_ENST00000375226.2_Missense_Mutation_p.R759G			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	759					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGCAGGAGGCGTGAAAGCACA	0.507000													35	60					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274291	39274291	+	Missense_Mutation	SNP	T	T	C	rs149439944	by1000genomes	TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr17:39274291T>C	ENST00000391413.2	-	1	315	c.277A>G	c.(277-279)Atg>Gtg	p.M93V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	93	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.M93V(4)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCAGCACATAGACTGGCAG	0.662000													4	70					0	0	1	0	0
IGHG2	3501	broad.mit.edu	37	14	106110069	106110069	+	RNA	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr14:106110069G>A	ENST00000390545.2	-	0	548																											CGGTGAGGACGCTGACCACAC	0.582000													82	246					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219301263	219301263	+	Missense_Mutation	SNP	G	G	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:219301263G>C	ENST00000248444.5	+	16	1973	c.1885G>C	c.(1885-1887)Ggg>Cgg	p.G629R	VIL1_ENST00000392114.2_Missense_Mutation_p.G318R	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	629	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity	p.G629W(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAACAAGACTGGGCGCTTCCT	0.522000													65	151					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38938335	38938335	+	Splice_Site	SNP	C	C	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr3:38938335C>A	ENST00000302328.3	-	14	2602		c.e14+1		SCN11A_ENST00000450244.1_Splice_Site|SCN11A_ENST00000444237.2_Splice_Site|SCN11A_ENST00000456224.3_Splice_Site	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit						response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAGACACATACCACAAGTTTT	0.308000													4	16					1	1	1	1	0
HNRNPA2B1	3181	broad.mit.edu	37	7	26232191	26232191	+	Missense_Mutation	SNP	T	T	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr7:26232191T>C	ENST00000354667.4	-	11	1175	c.1007A>G	c.(1006-1008)tAt>tGt	p.Y336C	HNRNPA2B1_ENST00000356674.7_Missense_Mutation_p.Y324C	NM_031243.2	NP_112533.1	P22626	ROA2_HUMAN	heterogeneous nuclear ribonucleoprotein A2/B1	336	Gly-rich.|Nuclear targeting sequence (By similarity).				RNA transport	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding|single-stranded telomeric DNA binding		HNRNPA2B1/ETV1(8)	breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	22						TCCTGGACCATAGTTTCCTAT	0.418000			T	ETV1	prostate								34	105					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82584955	82584955	+	Missense_Mutation	SNP	C	C	T			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr7:82584955C>T	ENST00000423517.2	-	5	5651	c.5314G>A	c.(5314-5316)Gat>Aat	p.D1772N	PCLO_ENST00000333891.8_Missense_Mutation_p.D1772N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1703					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCTGAAGAATCTTCAATAGTA	0.428000													30	88					0	0	1	0	0
CDC20	991	broad.mit.edu	37	1	43826790	43826790	+	Splice_Site	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr1:43826790G>A	ENST00000372462.1	+	8	1280		c.e8-1		CDC20_ENST00000310955.6_Splice_Site			Q12834	CDC20_HUMAN	cell division cycle 20						activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of synapse maturation|positive regulation of synaptic plasticity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	cytosol|nucleoplasm|spindle	enzyme binding|protein C-terminus binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	15	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATTCCATCTAGGCCGTAGCAT	0.557000													18	58					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11032424	11032424	+	Silent	SNP	C	C	T	rs147684194	byFrequency	TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr19:11032424C>T	ENST00000327064.4	+	16	2008	c.1818C>T	c.(1816-1818)taC>taT	p.Y606Y	CARM1_ENST00000344150.4_Silent_p.Y583Y	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	606	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						CCATGCACTACGGGAGCTAGG	0.662000													12	163					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205238182	205238182	+	Silent	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr1:205238182G>A	ENST00000358024.3	+	3	1241	c.852G>A	c.(850-852)cgG>cgA	p.R284R	TMCC2_ENST00000545499.1_Silent_p.R206R|TMCC2_ENST00000495538.1_3'UTR|TMCC2_ENST00000330675.7_Silent_p.R59R|TMCC2_ENST00000329800.7_Silent_p.R44R	NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	284						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			ACCCCCAGCGGACCAAGGCCG	0.637000													25	127					0	0	1	0	0
KCTD2	23510	broad.mit.edu	37	17	73059133	73059133	+	Silent	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr17:73059133G>A	ENST00000322444.6	+	6	789	c.783G>A	c.(781-783)tcG>tcA	p.S261S	KCTD2_ENST00000581589.1_Silent_p.S62S	NM_015353.1	NP_056168.1	Q14681	KCTD2_HUMAN	potassium channel tetramerization domain containing 2	261						voltage-gated potassium channel complex	voltage-gated potassium channel activity			kidney(1)|lung(2)	3	all_lung(278;0.226)					AGAGAGGATCGCGGATGTAAA	0.557000													4	47					0	0	1	0	0
CHRNA1	1134	broad.mit.edu	37	2	175618381	175618381	+	Missense_Mutation	SNP	A	A	C			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:175618381A>C	ENST00000348749.5	-	6	705	c.628T>G	c.(628-630)Tat>Gat	p.Y210D	CHRNA1_ENST00000409323.1_Missense_Mutation_p.Y210D|CHRNA1_ENST00000409542.1_Missense_Mutation_p.Y128D|CHRNA1_ENST00000409219.1_Missense_Mutation_p.Y210D|AC018890.6_ENST00000442996.1_RNA|CHRNA1_ENST00000261007.5_Missense_Mutation_p.Y235D	NM_000079.3	NP_000070.1	P02708	ACHA_HUMAN	cholinergic receptor, nicotinic, alpha 1 (muscle)	235					muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|ovary(3)|prostate(3)|skin(4)	37						CAGCAGGAATAGGTCACGGAG	0.592000													11	103					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871082	170871082	+	Silent	SNP	G	G	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr6:170871082G>A	ENST00000392092.2	+	3	537	c.258G>A	c.(256-258)caG>caA	p.Q86Q	TBP_ENST00000540980.1_Silent_p.Q66Q|TBP_ENST00000230354.6_Silent_p.Q86Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	86	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q86Q(2)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.612000													5	56					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	237024474	237024474	+	Frame_Shift_Del	DEL	A	A	-			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr1:237024474delA	ENST00000366577.5	+	20	2487	c.2093delA	c.(2092-2094)cafs	p.Q698fs	MTR_ENST00000535889.1_Intron	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	698	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGTTAAACCAAAAAAAATAT	0.308													7	59	---	---	---	---					
WNT6	7475	broad.mit.edu	37	2	219724790	219724792	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr2:219724790_219724792delGCT	ENST00000233948.3	+	1	247_249	c.30_32delGCT	c.(28-33)ggg>gg	p.GL10del	WNT6_ENST00000486233.1_3'UTR	NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	10					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity	p.L17delL(1)		large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCCGCCTCGGGCTGCTGCTGCTG	0.773													2	4	---	---	---	---					
CTNNB1	1499	broad.mit.edu	37	3	41268759	41268760	+	In_Frame_Ins	INS	-	-	ACG			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr3:41268759_41268760insACG	ENST00000349496.5	+	7	1277_1278	c.997_998insACG	c.(997-999)cga>ACGcga	p.332_333insT	CTNNB1_ENST00000405570.1_In_Frame_Ins_p.332_333insT|CTNNB1_ENST00000453024.1_In_Frame_Ins_p.325_326insT|CTNNB1_ENST00000396183.3_In_Frame_Ins_p.332_333insT|CTNNB1_ENST00000396185.3_In_Frame_Ins_p.332_333insT	NM_001904.3	NP_001895.1	P35222	CTNB1_HUMAN	catenin (cadherin-associated protein), beta 1, 88kDa	332					adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding		CTNNB1/PLAG1(60)	NS(4)|adrenal_gland(103)|biliary_tract(43)|bone(21)|breast(7)|central_nervous_system(260)|cervix(9)|endometrium(293)|eye(1)|haematopoietic_and_lymphoid_tissue(60)|kidney(202)|large_intestine(269)|liver(1010)|lung(63)|oesophagus(6)|ovary(106)|pancreas(126)|parathyroid(11)|pituitary(111)|pleura(2)|prostate(31)|salivary_gland(13)|skin(103)|small_intestine(17)|soft_tissue(792)|stomach(165)|thyroid(55)|upper_aerodigestive_tract(2)|urinary_tract(8)	3893				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GACCTATACTTACGAAAAACTA	0.386		15	"""H, Mis, T"""	PLAG1	"""colorectal, cvarian,  hepatoblastoma, others, pleomorphic salivary adenoma"""				Pilomatrixoma, Familial Clustering of				8	60	---	---	---	---					
GCNT4	51301	broad.mit.edu	37	5	74324730	74324730	+	Frame_Shift_Del	DEL	A	A	-			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr5:74324730delA	ENST00000322348.4	-	1	1994	c.1133delT	c.(1132-1134)tcfs	p.F378fs		NM_016591.2	NP_057675.1	Q9P109	GCNT4_HUMAN	glucosaminyl (N-acetyl) transferase 4, core 2	378					protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(2)|skin(1)|stomach(2)	19		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		ACTGGGATAGAAAAAGCCTTC	0.438													7	41	---	---	---	---					
HLA-V	352962	broad.mit.edu	37	6	29761783	29761784	+	RNA	INS	-	-	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr6:29761783_29761784insG	ENST00000457107.1	+	0	1009_1010																											ggattggtgcaaagccctgctt	0.550													3	6	---	---	---	---					
MDFI	4188	broad.mit.edu	37	6	41621169	41621171	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr6:41621169_41621171delCTG	ENST00000373050.4	+	4	601_603	c.414_416delCTG	c.(412-417)ctc>ct	p.LC138del				Q99750	MDFI_HUMAN	MyoD family inhibitor	199					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			ACTCGTGCCTCTGCTGCTGCTGC	0.655													7	233	---	---	---	---					
CSMD3	114788	broad.mit.edu	37	8	114186064	114186064	+	Frame_Shift_Del	DEL	T	T	-			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr8:114186064delT	ENST00000297405.5	-	4	840	c.596delA	c.(595-597)agfs	p.K199fs	CSMD3_ENST00000352409.3_Frame_Shift_Del_p.K199fs|CSMD3_ENST00000455883.2_Frame_Shift_Del_p.K199fs|CSMD3_ENST00000343508.3_Frame_Shift_Del_p.K159fs	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	199	Sushi 1.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTAGCGGATCTTGTCCCCGAC	0.453										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	72	---	---	---	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	GCCGCC	-	rs11279082		TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr9:100616701_100616706delGCCGCC	ENST00000375123.3	+	1	1166_1171	c.505_510delGCCGCC	c.(505-510)del	p.AA177del		NM_004473.3	NP_004464.2	O00358	FOXE1_HUMAN	forkhead box E1 (thyroid transcription factor 2)	177	Ala-rich.|Poly-Ala.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.767													6	9	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													2	4	---	---	---	---					
APOC1P1	342	broad.mit.edu	37	19	45431267	45431268	+	RNA	INS	-	-	A			TCGA-62-A46V-01A-11D-A24D-08	TCGA-62-A46V-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c39c017-a02d-4ed9-bd4d-29e243c8ab82	1658aa2e-ddb3-4e73-aee4-33c3f640ce41	g.chr19:45431267_45431268insA	ENST00000574565.1	+	0	402					NR_028412.1																						TGAACAGATTGAAAAAAAAAAC	0.525													3	3	---	---	---	---					
