Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
F5	2153	broad.mit.edu	37	1	169524505	169524505	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:169524505G>A	ENST00000367796.3	-	7	1234	c.1033C>T	c.(1033-1035)Cgg>Tgg	p.R345W	F5_ENST00000546081.1_Missense_Mutation_p.R208W|F5_ENST00000367797.3_Missense_Mutation_p.R345W			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	345					cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TTCATGTGCCGCCTCTGCTCA	0.448000													13	105					0	0	0.016723	0	0
PTCH2	8643	broad.mit.edu	37	1	45294011	45294011	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:45294011G>A	ENST00000447098.2	-	13	1677	c.1666C>T	c.(1666-1668)Cgg>Tgg	p.R556W	PTCH2_ENST00000372192.3_Missense_Mutation_p.R556W	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	556					protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity	p.R556W(1)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					CAGTGGCGCCGCCGTAGGTCC	0.657000									Basal Cell Nevus syndrome				10	30					0	0	0.013537	0	0
KIF25	3834	broad.mit.edu	37	6	168443325	168443325	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:168443325C>A	ENST00000443060.2	+	9	1305	c.914C>A	c.(913-915)gCt>gAt	p.A305D	KIF25_ENST00000354419.2_Missense_Mutation_p.A305D|KIF25_ENST00000351261.3_Intron			Q9UIL4	KIF25_HUMAN	kinesin family member 25	305					microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		GTCCTGGGGGCTTTGTTGGAG	0.652000													15	49					2.61681e-11	4.32952e-11	0.020292	1	0
RP1	6101	broad.mit.edu	37	8	55537288	55537288	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:55537288A>T	ENST00000220676.1	+	4	994	c.846A>T	c.(844-846)aaA>aaT	p.K282N		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	282					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CTTCTGAGAAAACACATAATA	0.323000													20	52					0	0	0.007413	0	0
OR1N2	138882	broad.mit.edu	37	9	125315572	125315572	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:125315572C>G	ENST00000373688.2	+	1	182	c.124C>G	c.(124-126)Cct>Gct	p.P42A		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						AGAGGAGCAGCCTCTTCTGTT	0.527000													20	60					0	0	0.007413	0	0
BLK	640	broad.mit.edu	37	8	11412354	11412354	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:11412354G>A	ENST00000259089.4	+	7	1167	c.575G>A	c.(574-576)cGg>cAg	p.R192Q	BLK_ENST00000529894.1_Missense_Mutation_p.R121Q	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	192	SH2.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		ATCTCCCCCCGGATCACCTTC	0.597000													14	24					0	0	0.024245	0	0
TCEANC	170082	broad.mit.edu	37	X	13680883	13680883	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:13680883G>T	ENST00000380600.1	+	2	343	c.256G>T	c.(256-258)Gcg>Tcg	p.A86S	TCEANC_ENST00000314720.4_Missense_Mutation_p.A116S|TCEANC_ENST00000490617.1_3'UTR|TCEANC_ENST00000544987.1_Missense_Mutation_p.A86S|TCEANC_ENST00000545566.1_Missense_Mutation_p.A86S			Q8N8B7	TEANC_HUMAN	transcription elongation factor A (SII) N-terminal and central domain containing	86					regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)|large_intestine(5)|lung(2)|pancreas(1)	9						TCACTCCAAAGCGAGGAACAG	0.438000													5	24					0.014758	0.0157542	0.014758	1	0
SLC1A3	6507	broad.mit.edu	37	5	36677170	36677170	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:36677170C>A	ENST00000265113.4	+	6	1220	c.744C>A	c.(742-744)gtC>gtA	p.V248V	SLC1A3_ENST00000381918.3_Silent_p.V248V|CTD-2353F22.1_ENST00000510740.1_RNA	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	248					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	GTCTAGTTGTCTTCTCCATGT	0.498000													72	57					1.93348e-29	4.13448e-29	0.014410	1	0
KMO	8564	broad.mit.edu	37	1	241752098	241752098	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:241752098C>A	ENST00000366559.4	+	12	1375	c.1064C>A	c.(1063-1065)gCg>gAg	p.A355E	KMO_ENST00000366558.3_Missense_Mutation_p.A355E|KMO_ENST00000366557.4_Missense_Mutation_p.A355E	NM_003679.4	NP_003670.2	O15229	KMO_HUMAN	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	355					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity	p.A355G(1)		NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)	33	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GATGATCACGCGATTTCAGAC	0.363000													11	40					0.000219431	0.000257709	0.020292	1	0
SULF1	23213	broad.mit.edu	37	8	70539497	70539497	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:70539497T>C	ENST00000260128.4	+	16	2620	c.1903T>C	c.(1903-1905)Tcg>Ccg	p.S635P	SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Missense_Mutation_p.S635P|SULF1_ENST00000458141.2_Missense_Mutation_p.S635P|SULF1_ENST00000419716.3_Missense_Mutation_p.S635P	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	635					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			ACTGTACCAATCGGCCAGAGC	0.418000													7	34					0	0	0.004482	0	0
WDR64	128025	broad.mit.edu	37	1	241886722	241886722	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:241886722G>T	ENST00000366552.2	+	9	1355	c.1148G>T	c.(1147-1149)aGc>aTc	p.S383I	WDR64_ENST00000437684.2_Missense_Mutation_p.S383I	NM_144625.4	NP_653226.4	B1ANS9	WDR64_HUMAN	WD repeat domain 64	383										breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(17)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CATGTCGTCAGCCTTTCCTCT	0.393000													13	40					1.41608e-15	2.67481e-15	0.016723	1	0
ACBD6	84320	broad.mit.edu	37	1	180257516	180257516	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:180257516G>A	ENST00000367595.3	-	8	1518	c.831C>T	c.(829-831)caC>caT	p.H277H	ACBD6_ENST00000475338.2_5'UTR	NM_032360.3	NP_115736.1	Q9BR61	ACBD6_HUMAN	acyl-CoA binding domain containing 6	277						cytoplasm|nucleus	fatty-acyl-CoA binding		ACBD6/RRP15(2)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|ovary(1)	7						TGCCAGTTGTGTGCCGCTGCA	0.473000													9	45					0	0	0.008291	0	0
HLA-DQB1	3119	broad.mit.edu	37	6	32629750	32629750	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:32629750C>A	ENST00000399084.1	-	4	833	c.655G>T	c.(655-657)Gag>Tag	p.E219*	XXbac-BPG254F23.6_ENST00000443574.1_RNA|HLA-DQB1_ENST00000434651.2_Nonsense_Mutation_p.E219*|HLA-DQB1_ENST00000399079.3_Nonsense_Mutation_p.E219*|HLA-DQB1_ENST00000399082.3_Nonsense_Mutation_p.E129*|HLA-DQB1_ENST00000374943.4_Nonsense_Mutation_p.E219*			P01920	DQB1_HUMAN	major histocompatibility complex, class II, DQ beta 1	219	Beta-2.|Ig-like C1-type.				antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			breast(1)|large_intestine(1)|lung(1)|pancreas(1)	4					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTACGCCACTCCACGGTGATG	0.537000									T-cell Lymphoma, (Cutaneous) , Familial Clustering of;Sjgren syndrome;Melanoma, Familial Clustering of;ACTH-independent macronodular adrenal hyperplasia				8	50					2.62699e-14	4.78915e-14	0.024245	1	0
CALCR	799	broad.mit.edu	37	7	93072917	93072917	+	Splice_Site	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:93072917C>G	ENST00000359558.2	-	11	1202	c.904_splice	c.e11+1	p.W301_splice	CALCR_ENST00000421592.1_Splice_Site_p.W283_splice|CALCR_ENST00000394441.1_Splice_Site_p.W267_splice|CALCR_ENST00000426151.1_Splice_Site_p.W267_splice|CALCR_ENST00000360249.4_Splice_Site_p.W283_splice	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	283					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	AATACATACCCCAGCCCAAGA	0.438000													12	53					0	0	0.010729	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33616054	33616054	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:33616054C>G	ENST00000504830.1	-	15	2602	c.2267G>C	c.(2266-2268)gGg>gCg	p.G756A	ADAMTS12_ENST00000352040.3_Missense_Mutation_p.G671A|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	756	Spacer 1.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.G756V(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GATAATAAACCCTCCATTCAG	0.478000										HNSCC(64;0.19)			30	242					0	0	0.012213	0	0
PLXDC2	84898	broad.mit.edu	37	10	20465966	20465966	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:20465966G>T	ENST00000377252.3	+	8	1763	c.922G>T	c.(922-924)Gag>Tag	p.E308*	PLXDC2_ENST00000377242.3_Nonsense_Mutation_p.E259*|PLXDC2_ENST00000377238.2_3'UTR	NM_032812.7	NP_116201.7	Q6UX71	PXDC2_HUMAN	plexin domain containing 2	308						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(9)|ovary(2)|skin(3)|stomach(1)	34						CCACCGAGTAGAGCTACAAAT	0.343000													9	107					0.000978159	0.00112546	0.010729	1	0
ITGAE	3682	broad.mit.edu	37	17	3649152	3649152	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:3649152C>A	ENST00000263087.4	-	18	2323	c.2225G>T	c.(2224-2226)tGt>tTt	p.C742F		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	742					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		TACGTCTGAACACTGCAGCCG	0.587000													19	52					6.49762e-13	1.12714e-12	0.006122	1	0
GRM3	2913	broad.mit.edu	37	7	86468419	86468419	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:86468419T>A	ENST00000361669.2	+	4	2688	c.1589T>A	c.(1588-1590)aTt>aAt	p.I530N	GRM3_ENST00000536043.1_Missense_Mutation_p.I402N|GRM3_ENST00000439827.1_Intron|GRM3_ENST00000546348.1_Missense_Mutation_p.I122N|GRM3_ENST00000394720.2_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	530					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TGCTGCTGGATTTGCATCCCC	0.537000													7	141					0	0	0.003080	0	0
DNAJC12	56521	broad.mit.edu	37	10	69571290	69571290	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:69571290C>A	ENST00000225171.2	-	3	441	c.289G>T	c.(289-291)Gtg>Ttg	p.V97L	DNAJC12_ENST00000339758.7_Missense_Mutation_p.V97L|DNAJC12_ENST00000483798.2_Missense_Mutation_p.V127L	NM_021800.2	NP_068572.1	Q9UKB3	DJC12_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 12	97					protein folding		heat shock protein binding|unfolded protein binding			breast(2)|kidney(2)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	12						ACCGTCTTCACTGAGTCATTC	0.507000													45	101					1.23103e-26	2.61594e-26	0.013114	1	0
SAMD13	148418	broad.mit.edu	37	1	84815393	84815393	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:84815393T>C	ENST00000370673.3	+	4	479	c.287T>C	c.(286-288)cTg>cCg	p.L96P	SAMD13_ENST00000370667.3_Missense_Mutation_p.L72P|SAMD13_ENST00000370671.3_Missense_Mutation_p.L102P|SAMD13_ENST00000370670.2_Missense_Mutation_p.L82P|SAMD13_ENST00000394834.3_Missense_Mutation_p.L82P|SAMD13_ENST00000370669.1_Missense_Mutation_p.L82P|SAMD13_ENST00000370668.3_Missense_Mutation_p.L82P|RP11-376N17.4_ENST00000505585.1_RNA	NM_001010971.2	NP_001010971.1	Q5VXD3	SAM13_HUMAN	sterile alpha motif domain containing 13	102	SAM.									lung(4)	4				all cancers(265;0.00667)|Epithelial(280;0.0219)|OV - Ovarian serous cystadenocarcinoma(397;0.136)		GGGCCTGCTCTGAAAATCTAC	0.373000													28	115					0	0	0.009535	0	0
ZNF766	90321	broad.mit.edu	37	19	52793794	52793794	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:52793794G>A	ENST00000439461.1	+	4	793	c.750G>A	c.(748-750)aaG>aaA	p.K250K	CTD-2525I3.5_ENST00000594865.1_RNA|ZNF766_ENST00000359102.4_Silent_p.K265K|ZNF766_ENST00000599581.1_3'UTR|ZNF766_ENST00000593612.1_Silent_p.K265K	NM_001010851.2	NP_001010851.1	Q5HY98	ZN766_HUMAN	zinc finger protein 766	250					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	17				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		AGTGTGGCAAGCTCTTCAATC	0.443000													13	18					0	0	0.013537	0	0
NKTR	4820	broad.mit.edu	37	3	42679196	42679196	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:42679196G>A	ENST00000232978.8	+	13	2188	c.2000G>A	c.(1999-2001)aGa>aAa	p.R667K	RP4-613B23.1_ENST00000445452.1_RNA|RP4-613B23.1_ENST00000438017.1_RNA|RP4-613B23.1_ENST00000434363.1_RNA	NM_005385.3	NP_005376.2	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	667	Arg/Ser-rich.				protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			breast(3)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(10)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	41				KIRC - Kidney renal clear cell carcinoma(284;0.24)		TACCATAAAAGAGAAAAAAAT	0.378000													10	76					0	0	0.006214	0	0
NLRP11	204801	broad.mit.edu	37	19	56313001	56313001	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:56313001A>T	ENST00000443188.1	-	7	2818	c.2108T>A	c.(2107-2109)cTa>cAa	p.L703Q	NLRP11_ENST00000589093.1_Missense_Mutation_p.L703Q|NLRP11_ENST00000360133.3_Missense_Mutation_p.L649Q|NLRP11_ENST00000589824.2_Missense_Mutation_p.L649Q|NLRP11_ENST00000592953.1_Missense_Mutation_p.L604Q	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	703							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		AAACATATTTAGGGAAATGGA	0.463000													23	49					0	0	0.024334	0	0
SLFN12	55106	broad.mit.edu	37	17	33738771	33738771	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:33738771G>A	ENST00000394562.1	-	6	1846	c.1323C>T	c.(1321-1323)ctC>ctT	p.L441L	SLFN12_ENST00000304905.5_Silent_p.L441L|SLFN12_ENST00000460530.1_5'UTR|SLFN12_ENST00000452764.3_Silent_p.L441L			Q8IYM2	SLN12_HUMAN	schlafen family member 12	441							ATP binding			breast(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GAGCATCACAGAGGACTTTGT	0.463000													35	62					0	0	0.019004	0	0
MRAP2	112609	broad.mit.edu	37	6	84765060	84765060	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:84765060C>A	ENST00000257776.4	+	2	158	c.23C>A	c.(22-24)tCt>tAt	p.S8Y		NM_138409.2	NP_612418.2	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	8					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(4)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	19						AGGTTAATTTCTAACAGAACC	0.433000													19	76					2.21704e-12	3.81667e-12	0.016522	1	0
SLC17A4	10050	broad.mit.edu	37	6	25777124	25777124	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:25777124C>T	ENST00000377905.4	+	10	1324	c.1205C>T	c.(1204-1206)tCt>tTt	p.S402F	SLC17A4_ENST00000439485.2_Missense_Mutation_p.S172F|SLC17A4_ENST00000397076.2_Missense_Mutation_p.S200F	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	402					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTGGTGCTGTCTTCTGCCATC	0.537000													26	103					0	0	0.024334	0	0
R3HDM1	23518	broad.mit.edu	37	2	136393668	136393668	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:136393668G>T	ENST00000264160.4	+	11	1188	c.818G>T	c.(817-819)cGt>cTt	p.R273L	R3HDM1_ENST00000329971.3_Missense_Mutation_p.R229L|R3HDM1_ENST00000410054.1_Missense_Mutation_p.R217L|R3HDM1_ENST00000409478.1_Missense_Mutation_p.R229L|R3HDM1_ENST00000409606.1_Missense_Mutation_p.R273L	NM_015361.2	NP_056176.2	Q15032	R3HD1_HUMAN	R3H domain containing 1	273							nucleic acid binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(3)|lung(14)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	38				BRCA - Breast invasive adenocarcinoma(221;0.127)		ATGAGAATACGTTTGAAAGAT	0.353000													30	85					7.26314e-15	1.33485e-14	0.034045	1	0
EPHA5	2044	broad.mit.edu	37	4	66213899	66213899	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:66213899C>A	ENST00000273854.3	-	15	3131	c.2531G>T	c.(2530-2532)tGg>tTg	p.W844L	EPHA5_ENST00000511294.1_Missense_Mutation_p.W845L|EPHA5_ENST00000354839.4_Missense_Mutation_p.W822L|EPHA5_ENST00000432638.2_Missense_Mutation_p.W681L	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	844	Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity	p.W844L(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TGGGGCAGTCCATCTGATTGG	0.393000										TSP Lung(17;0.13)			8	78					1.12685e-05	1.46233e-05	0.004482	1	0
PCDHB11	56125	broad.mit.edu	37	5	140580956	140580956	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:140580956G>A	ENST00000354757.3	+	1	1609	c.1609G>A	c.(1609-1611)Ggc>Agc	p.G537S	PCDHB11_ENST00000536699.1_Missense_Mutation_p.G172S	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		537	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACAGACCGCGGCTCCCCGGC	0.672000													24	74					0	0	0.021523	0	0
CDH9	1007	broad.mit.edu	37	5	26902674	26902674	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:26902674G>T	ENST00000231021.4	-	7	1336	c.1164C>A	c.(1162-1164)taC>taA	p.Y388*		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	388	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						CTTCTATCAAGTAAGAGACTT	0.393000													7	195					0.000274275	0.000319361	0.004482	1	0
MYH2	4620	broad.mit.edu	37	17	10432977	10432977	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:10432977C>A	ENST00000245503.5	-	24	3405	c.3021G>T	c.(3019-3021)gaG>gaT	p.E1007D	CTC-297N7.7_ENST00000587182.1_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E1007D|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1007					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCTGGTGGGCCTCCTGGAGAG	0.483000													34	110					1.63038e-21	3.29957e-21	0.014410	1	0
LPA	4018	broad.mit.edu	37	6	160977168	160977168	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:160977168C>A	ENST00000447678.1	-	31	4982	c.4862G>T	c.(4861-4863)gGc>gTc	p.G1621V	LPA_ENST00000316300.5_Missense_Mutation_p.G1621V	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	4129	Kringle 15.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ATAACTCTGGCCATTACCATG	0.488000													30	128					3.1745e-13	5.53502e-13	0.037714	1	0
NR1D2	9975	broad.mit.edu	37	3	24001260	24001260	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:24001260G>C	ENST00000312521.4	+	4	790	c.471G>C	c.(469-471)caG>caC	p.Q157H	NR1D2_ENST00000492552.1_3'UTR	NM_001145425.1|NM_005126.4	NP_001138897.1|NP_005117.3	Q14995	NR1D2_HUMAN	nuclear receptor subfamily 1, group D, member 2	157					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|zinc ion binding			NS(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	22						ACAGATGTCAGCAATGTCGCT	0.378000													18	99					0	0	0.008871	0	0
SLIT2	9353	broad.mit.edu	37	4	20525799	20525799	+	Splice_Site	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:20525799A>T	ENST00000504154.1	+	14	1689	c.1438_splice	c.e14+1	p.S479_splice	SLIT2_ENST00000503837.1_Splice_Site_p.S483_splice|SLIT2_ENST00000273739.5_Splice_Site_p.S483_splice|SLIT2_ENST00000503823.1_Splice_Site_p.S479_splice	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	479	LRRCT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TCCGTTGTTCAGGTAATTTCT	0.478000													24	88					0	0	0.014323	0	0
AQR	9716	broad.mit.edu	37	15	35202392	35202392	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:35202392C>T	ENST00000156471.5	-	17	1832	c.1607G>A	c.(1606-1608)cGt>cAt	p.R536H		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	536						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		AACATCTGCACGAACTCGGGT	0.448000													25	102					0	0	0.030593	0	0
RLBP1	6017	broad.mit.edu	37	15	89761919	89761919	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:89761919G>T	ENST00000268125.5	-	4	457	c.18C>A	c.(16-18)ggC>ggA	p.G6G		NM_000326.4	NP_000317.1	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	6					response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(1)|prostate(1)|skin(1)	18	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	TGCGGAACGTGCCCACCTGGG	0.582000													11	33					1.33987e-11	2.24966e-11	0.008291	1	0
ZNF208	7757	broad.mit.edu	37	19	22154113	22154113	+	Silent	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:22154113A>T	ENST00000397126.4	-	4	3871	c.3723T>A	c.(3721-3723)acT>acA	p.T1241T	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CCTTATGTTTAGTGAGGATTG	0.388000													10	56					0	0	0.008291	0	0
CCR8	1237	broad.mit.edu	37	3	39373851	39373851	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:39373851C>A	ENST00000326306.4	+	2	167	c.29C>A	c.(28-30)aCa>aAa	p.T10K	CCR8_ENST00000414803.1_Missense_Mutation_p.T10K|CCR8_ENST00000545843.1_5'UTR	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	10					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		CTCAGTGTGACAACAGTGACC	0.413000													16	81					3.99206e-14	7.23893e-14	0.007413	1	0
BAZ2B	29994	broad.mit.edu	37	2	160295207	160295207	+	Splice_Site	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:160295207C>A	ENST00000392783.2	-	8	1396		c.e8-1		BAZ2B_ENST00000343439.5_Splice_Site|BAZ2B_ENST00000355831.2_Splice_Site|BAZ2B_ENST00000392782.1_Splice_Site	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						GTAATAGCACCTAGATATAAA	0.373000													29	125					1.7881e-09	2.82113e-09	0.037714	1	0
XIRP2	129446	broad.mit.edu	37	2	168102003	168102003	+	Silent	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:168102003T>A	ENST00000409195.1	+	9	4190	c.4101T>A	c.(4099-4101)acT>acA	p.T1367T	XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000295237.9_Silent_p.T1367T|XIRP2_ENST00000409273.1_Silent_p.T1145T|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1192					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AATCAGAAACTGTGTATGTTA	0.368000													25	65					0	0	0.016522	0	0
TP53	7157	broad.mit.edu	37	17	7577547	7577547	+	Missense_Mutation	SNP	C	C	A	rs121912656		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:7577547C>A	ENST00000420246.2	-	7	866	c.734G>T	c.(733-735)gGc>gTc	p.G245V	TP53_ENST00000359597.4_Missense_Mutation_p.G245V|TP53_ENST00000413465.2_Missense_Mutation_p.G245V|TP53_ENST00000455263.2_Missense_Mutation_p.G245V|TP53_ENST00000445888.2_Missense_Mutation_p.G245V|TP53_ENST00000269305.4_Missense_Mutation_p.G245V	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	245	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		G -> A (in sporadic cancers; somatic mutation).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> S (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs28934575).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245D(104)|p.G245V(66)|p.G245A(8)|p.0?(8)|p.?(5)|p.G152V(4)|p.G244_M246>V(3)|p.G152D(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.G245fs*2(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.M243fs*18(1)|p.C238_M246delCNSSCMGGM(1)|p.G151_M153>V(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCGGTTCATGCCGCCCATGCA	0.582000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	43					0.00307968	0.00343872	0.003080	1	0
USP51	158880	broad.mit.edu	37	X	55514457	55514457	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:55514457C>A	ENST00000500968.3	-	2	998	c.916G>T	c.(916-918)Gaa>Taa	p.E306*	USP51_ENST00000586165.1_Intron	NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	306					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						AAAATTTTTTCTTTTGTTTCT	0.343000													4	72					0.00024832	0.000289636	0.009096	1	0
KCNF1	3754	broad.mit.edu	37	2	11053045	11053045	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:11053045C>A	ENST00000295082.1	+	1	983	c.493C>A	c.(493-495)Cag>Aag	p.Q165K		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	165						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		GCGCCGCTGCCAGAAGTGCGT	0.697000													8	40					1.58986e-06	2.1579e-06	0.008291	1	0
TTLL11	158135	broad.mit.edu	37	9	124751430	124751430	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:124751430C>A	ENST00000373776.3	-	4	1770	c.1583G>T	c.(1582-1584)gGc>gTc	p.G528V	TTLL11_ENST00000474723.1_Intron|TTLL11_ENST00000321582.5_Intron	NM_194252.2	NP_919228.2	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	528	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(3)|skin(1)	18						CCTCTTGAGGCCGGTCAAGGC	0.602000													24	51					7.88262e-20	1.56731e-19	0.018920	1	0
PHKA1	5255	broad.mit.edu	37	X	71856209	71856209	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:71856209C>T	ENST00000373545.3	-	15	1925	c.1487G>A	c.(1486-1488)gGa>gAa	p.G496E	PHKA1_ENST00000541944.1_Missense_Mutation_p.G496E|PHKA1_ENST00000339490.3_Missense_Mutation_p.G496E|PHKA1_ENST00000373539.3_Missense_Mutation_p.G496E|PHKA1_ENST00000373542.4_Missense_Mutation_p.G496E			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	496					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					GTAGGGTCGTCCACTGAGTTT	0.363000													13	70					0	0	0.020292	0	0
IER5	51278	broad.mit.edu	37	1	181058374	181058374	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:181058374G>T	ENST00000367577.4	+	1	737	c.336G>T	c.(334-336)cgG>cgT	p.R112R		NM_016545.4	NP_057629.2	Q5VY09	IER5_HUMAN	immediate early response 5	112										lung(1)|ovary(1)|pancreas(1)|urinary_tract(1)	4						ACGCGCCGCGGGTAGGGGACG	0.751000													4	8					0.000157383	0.000186772	0.003080	1	0
NFU1	27247	broad.mit.edu	37	2	69646724	69646724	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:69646724C>A	ENST00000410022.2	-	4	520	c.315G>T	c.(313-315)agG>agT	p.R105S	NFU1_ENST00000471185.1_5'UTR|NFU1_ENST00000303698.3_Missense_Mutation_p.R81S|NFU1_ENST00000394305.1_5'UTR	NM_001002755.2	NP_001002755.1	Q9UMS0	NFU1_HUMAN	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	105					iron-sulfur cluster assembly	cytosol|mitochondrion|nucleus	4 iron, 4 sulfur cluster binding|iron ion binding|protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(1)|prostate(1)|skin(1)	7						CTCCTTCAATCCTAAATAACT	0.269000													3	6					0.014758	0.0157542	0.014758	1	0
DRC1	92749	broad.mit.edu	37	2	26676259	26676259	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:26676259G>T	ENST00000288710.2	+	14	1835	c.1761G>T	c.(1759-1761)gaG>gaT	p.E587D		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		CAGAATTggagctggcagagc	0.582000													20	81					1.37878e-21	2.79872e-21	0.018920	1	0
LMO4	8543	broad.mit.edu	37	1	87805252	87805252	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:87805252C>A	ENST00000370544.5	+	3	1050	c.270C>A	c.(268-270)tgC>tgA	p.C90*	LMO4_ENST00000370542.1_Nonsense_Mutation_p.C90*|LMO4_ENST00000489303.1_3'UTR	NM_006769.3	NP_006760.1	P61968	LMO4_HUMAN	LIM domain only 4	90	LIM zinc-binding 2.				neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(1)	9		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		GCAGCGCTTGCGGACAGTCGA	0.388000													13	24					4.7546e-09	7.38158e-09	0.028581	1	0
CTBP1	1487	broad.mit.edu	37	4	1206751	1206751	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:1206751G>A	ENST00000382952.3	-	9	1440	c.1056C>T	c.(1054-1056)gcC>gcT	p.A352A	CTBP1_ENST00000290921.6_Silent_p.A363A	NM_001012614.1	NP_001012632.1	Q13363	CTBP1_HUMAN	C-terminal binding protein 1	363	Interaction with GLIS2 2 (By similarity).				interspecies interaction between organisms|negative regulation of cell proliferation|negative regulation of histone H4 acetylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of histone deacetylation|protein phosphorylation|regulation of cell cycle|regulation of transcription by chromatin organization|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|viral genome replication|white fat cell differentiation	cytoplasm|transcriptional repressor complex	NAD binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor|protein C-terminus binding|protein domain specific binding|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|urinary_tract(1)	8			OV - Ovarian serous cystadenocarcinoma(23;0.00818)	Colorectal(103;0.2)		GGTCCATGCTGGCCCAGTGGG	0.647000													11	56					0	0	0.024245	0	0
PKN3	29941	broad.mit.edu	37	9	131469303	131469303	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:131469303G>T	ENST00000291906.4	+	5	1044		c.e5+1			NM_013355.3	NP_037487.2	Q6P5Z2	PKN3_HUMAN	protein kinase N3						signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm	ATP binding|protein binding|protein kinase C activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|pancreas(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24						ACTGGCTGAGGTCAGGCCCCA	0.612000													18	41					2.37509e-13	4.16253e-13	0.010504	1	0
COL11A1	1301	broad.mit.edu	37	1	103491416	103491416	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:103491416T>A	ENST00000358392.2	-	6	1190	c.873A>T	c.(871-873)aaA>aaT	p.K291N	COL11A1_ENST00000512756.1_Intron|COL11A1_ENST00000370096.3_Intron|COL11A1_ENST00000353414.4_Intron	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	293	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGATGAAAATTTTTCAGATT	0.343000													23	125					0	0	0.014323	0	0
SRCAP	10847	broad.mit.edu	37	16	30749056	30749056	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:30749056G>T	ENST00000262518.4	+	34	8080	c.7695G>T	c.(7693-7695)gaG>gaT	p.E2565D	SRCAP_ENST00000344771.4_Missense_Mutation_p.E2407D|SRCAP_ENST00000395059.2_Missense_Mutation_p.E2503D	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2565	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			AGTCCCTGGAGCTGGCTTCTG	0.557000													20	78					0.000958276	0.00110633	0.007413	1	0
PCDHB14	56122	broad.mit.edu	37	5	140603183	140603183	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:140603183G>T	ENST00000239449.4	+	1	106	c.106G>T	c.(106-108)Gca>Tca	p.A36S	PCDHB14_ENST00000515856.2_Intron	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		36	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTATTCTGTGGCAGAGGAAAC	0.512000													14	34					0.000219431	0.000257709	0.020292	1	0
ASGR1	432	broad.mit.edu	37	17	7077011	7077011	+	Silent	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:7077011C>G	ENST00000574388.1	-	7	1518	c.726G>C	c.(724-726)ctG>ctC	p.L242L	ASGR1_ENST00000269299.3_Silent_p.L281L|ASGR1_ENST00000380920.4_Silent_p.L180L			P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	281	C-type lectin.				receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	10						TGGCCTTGTCCAGCTCTGTCT	0.637000													7	46					0	0	0.004482	0	0
SLC6A15	55117	broad.mit.edu	37	12	85279265	85279265	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:85279265G>T	ENST00000450363.3	-	4	981	c.523C>A	c.(523-525)Caa>Aaa	p.Q175K	SLC6A15_ENST00000266682.5_Missense_Mutation_p.Q175K|SLC6A15_ENST00000552192.1_Missense_Mutation_p.Q68K|SLC6A15_ENST00000551388.1_Intron	NM_018057.6	NP_060527.2	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	175					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						GGCAGGGGTTGCTGAAAAGAC	0.363000													9	46					0.00829132	0.00907906	0.008291	1	0
PRAME	23532	broad.mit.edu	37	22	22890900	22890900	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:22890900C>T	ENST00000543184.1	-	5	1981	c.1119G>A	c.(1117-1119)ctG>ctA	p.L373L	PRAME_ENST00000405655.3_Silent_p.L373L|PRAME_ENST00000398741.1_Silent_p.L373L|PRAME_ENST00000398743.2_Silent_p.L373L|PRAME_ENST00000402697.1_Silent_p.L373L|PRAME_ENST00000539862.1_Silent_p.L357L|PRAME_ENST00000424204.2_Silent_p.L357L	NM_206953.1	NP_996836.1	P78395	PRAME_HUMAN	preferentially expressed antigen in melanoma	373					apoptosis|cell differentiation|negative regulation of apoptosis|negative regulation of cell differentiation|negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|regulation of growth|transcription, DNA-dependent	nucleus|plasma membrane	retinoic acid receptor binding			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)|all_lung(157;4.03e-05)		READ - Rectum adenocarcinoma(21;0.0649)		AGGCTCTCTCCAGCAGAGCTT	0.592000													43	72					0	0	0.010771	0	0
DAGLB	221955	broad.mit.edu	37	7	6449644	6449644	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:6449644G>A	ENST00000297056.6	-	15	2012	c.1843C>T	c.(1843-1845)Cac>Tac	p.H615Y	DAGLB_ENST00000428902.2_3'UTR|DAGLB_ENST00000436575.1_Missense_Mutation_p.H574Y|DAGLB_ENST00000425398.2_Missense_Mutation_p.H486Y	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta	615					lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		GCGCTATAGTGAGCAGCAGAG	0.597000													5	66					0	0	0.021553	0	0
SUGP2	10147	broad.mit.edu	37	19	19136604	19136604	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:19136604C>G	ENST00000601879.1	-	3	850	c.553G>C	c.(553-555)Gag>Cag	p.E185Q	SUGP2_ENST00000600377.1_Missense_Mutation_p.E199Q|SUGP2_ENST00000452918.2_Missense_Mutation_p.E185Q|SUGP2_ENST00000337018.6_Missense_Mutation_p.E185Q|SUGP2_ENST00000456085.2_Intron|SUGP2_ENST00000598202.1_5'UTR			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	185					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CTCTCCTTCTCCAAACACTCT	0.517000													5	46					0	0	0.021553	0	0
FRMD3	257019	broad.mit.edu	37	9	85926822	85926822	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:85926822C>T	ENST00000304195.3	-	8	959	c.753G>A	c.(751-753)aaG>aaA	p.K251K	FRMD3_ENST00000376434.1_Silent_p.K57K|FRMD3_ENST00000376438.1_Silent_p.K251K	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	251	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						AATGGATTCTCTTATTTCCCT	0.383000													8	37					0	0	0.012319	0	0
LY6G5B	58496	broad.mit.edu	37	6	31638977	31638977	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:31638977G>T	ENST00000375864.4	+	2	887	c.103G>T	c.(103-105)Gac>Tac	p.D35Y	LY6G5B_ENST00000409525.1_5'UTR|CSNK2B-LY6G5B-1181_ENST00000375880.2_Missense_Mutation_p.R201I	NM_021221.2	NP_067044.2	Q8NDX9	LY65B_HUMAN	lymphocyte antigen 6 complex, locus G5B	35	UPAR/Ly6.					extracellular region				lung(4)	4						CCTCGTAGAAGACCCTTCTGT	0.537000													38	185					6.19805e-25	1.29284e-24	0.023175	1	0
TLR1	7096	broad.mit.edu	37	4	38798817	38798817	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:38798817C>A	ENST00000308979.2	-	4	1909	c.1636G>T	c.(1636-1638)Gtg>Ttg	p.V546L	TLR1_ENST00000502213.2_Missense_Mutation_p.V546L	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	546	LRRCT.				cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						CCCTCTAACACTTCACTTGAT	0.413000													58	301					2.93687e-30	6.31985e-30	0.014410	1	0
KCND2	3751	broad.mit.edu	37	7	120387741	120387741	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:120387741C>A	ENST00000331113.4	+	6	2687	c.1722C>A	c.(1720-1722)tcC>tcA	p.S574S	RP4-797C5.2_ENST00000450480.1_RNA	NM_012281.2	NP_036413.1	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 2	574					regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			NS(2)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(35)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	75	all_neural(327;0.117)					TCAGCCGATCCAGTTTAAATG	0.313000													12	41					3.07112e-06	4.10287e-06	0.010729	1	0
ITPR3	3710	broad.mit.edu	37	6	33652441	33652441	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:33652441G>T	ENST00000374316.5	+	39	6173	c.5113G>T	c.(5113-5115)Gac>Tac	p.D1705Y	ITPR3_ENST00000605930.1_Missense_Mutation_p.D1705Y			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1705					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						CTCGCGGGGGGACCTTCCCGA	0.642000													18	60					6.94344e-10	1.10834e-09	0.006122	1	0
CHRNA4	1137	broad.mit.edu	37	20	61981752	61981752	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:61981752C>A	ENST00000370263.4	-	5	1232	c.1011G>T	c.(1009-1011)acG>acT	p.T337T	CHRNA4_ENST00000463705.1_5'UTR	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	337					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	GCATGGTGTGCGTGCGTGGCG	0.622000													11	49					0.0202918	0.0216276	0.020292	1	0
STX1B	112755	broad.mit.edu	37	16	31012463	31012463	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:31012463C>A	ENST00000215095.5	-	3	388	c.157G>T	c.(157-159)Gtg>Ttg	p.V53L	STX1B_ENST00000565419.1_Missense_Mutation_p.V53L	NM_052874.3	NP_443106.1	P61266	STX1B_HUMAN	syntaxin 1B	53					intracellular protein transport|neurotransmitter transport|synaptic transmission	integral to plasma membrane	extracellular-glutamate-gated ion channel activity|SNAP receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(5)	13						TGTTTTTTCACCTGCTCCACA	0.582000													10	70					1.76689e-08	2.65229e-08	0.006214	1	0
FAM83D	81610	broad.mit.edu	37	20	37570728	37570728	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:37570728G>T	ENST00000217429.4	+	2	741	c.700G>T	c.(700-702)Gat>Tat	p.D234Y		NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D	204					cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				TCAATTTCTGGATATGTGCAT	0.428000													14	120					1.15088e-07	1.65804e-07	0.028581	1	0
ATAD2	29028	broad.mit.edu	37	8	124383531	124383531	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:124383531C>A	ENST00000287394.5	-	5	691	c.584G>T	c.(583-585)cGt>cTt	p.R195L	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			TCGCTGTCTACGCATCTTCTT	0.313000													5	38					8.12818e-05	9.85234e-05	0.029380	1	0
PIGW	284098	broad.mit.edu	37	17	34893860	34893860	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:34893860G>A	ENST00000592983.1	+	2	1490	c.910G>A	c.(910-912)Gaa>Aaa	p.E304K	MYO19_ENST00000590081.1_Intron|PIGW_ENST00000328396.2_Missense_Mutation_p.E304K			Q7Z7B1	PIGW_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class W	304					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	O-acyltransferase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13		Breast(25;0.00957)|Ovarian(249;0.17)	Kidney(155;0.104)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCCAACCGCGAAGGAATAAT	0.428000													8	76					0	0	0.003080	0	0
SLCO4A1	28231	broad.mit.edu	37	20	61303108	61303108	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:61303108G>T	ENST00000217159.1	+	12	2237	c.2032G>T	c.(2032-2034)Ggc>Tgc	p.G678C	SLCO4A1_ENST00000370507.1_Missense_Mutation_p.G678C	NM_016354.3	NP_057438.3	Q96BD0	SO4A1_HUMAN	solute carrier organic anion transporter family, member 4A1	678					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(3)|prostate(2)	21	Breast(26;3.65e-08)		BRCA - Breast invasive adenocarcinoma(19;2.33e-06)			CCAGGTGCTGGGCGTCCTCTT	0.627000													31	138					1.22384e-17	2.37774e-17	0.013726	1	0
TRANK1	9881	broad.mit.edu	37	3	36898278	36898278	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:36898278T>C	ENST00000301807.6	-	12	3050	c.1153A>G	c.(1153-1155)Aaa>Gaa	p.K385E	TRANK1_ENST00000428977.2_Missense_Mutation_p.K385E|TRANK1_ENST00000429976.2_Missense_Mutation_p.K935E	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	935					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						ACTTGGCCTTTATTGATACCT	0.498000													15	96					0	0	0.028581	0	0
PPFIA4	8497	broad.mit.edu	37	1	203025516	203025516	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:203025516G>T	ENST00000367240.2	+	17	2584	c.2057G>T	c.(2056-2058)cGg>cTg	p.R686L	PPFIA4_ENST00000414050.2_Missense_Mutation_p.R414L|PPFIA4_ENST00000447715.2_Missense_Mutation_p.R685L|PPFIA4_ENST00000599966.1_Missense_Mutation_p.R201L|PPFIA4_ENST00000272198.6_Missense_Mutation_p.R201L|PPFIA4_ENST00000295706.4_Missense_Mutation_p.R201L			O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4	201					cell communication	cell surface|cytoplasm	protein binding			NS(1)|autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(8)|lung(20)|ovary(4)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	50						CCAGTGTCTCGGGAAGAGAAC	0.592000													10	39					5.16669e-11	8.44554e-11	0.010729	1	0
ZNF208	7757	broad.mit.edu	37	19	22154114	22154114	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:22154114G>A	ENST00000397126.4	-	4	3870	c.3722C>T	c.(3721-3723)aCt>aTt	p.T1241I	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CTTATGTTTAGTGAGGATTGA	0.383000													10	58					0	0	0.008291	0	0
SLC9A9	285195	broad.mit.edu	37	3	143082363	143082363	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:143082363C>A	ENST00000316549.6	-	14	1775	c.1567G>T	c.(1567-1569)Gct>Tct	p.A523S		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	523					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						AAGAGCCGAGCACTCTCTGCT	0.373000													20	80					4.35082e-09	6.77015e-09	0.010504	1	0
XIRP2	129446	broad.mit.edu	37	2	168114604	168114604	+	Silent	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:168114604T>A	ENST00000409728.1	+	11	1736	c.1647T>A	c.(1645-1647)gcT>gcA	p.A549A	XIRP2_ENST00000409043.1_Silent_p.A516A|XIRP2_ENST00000295237.9_3'UTR|XIRP2_ENST00000409273.1_3'UTR|XIRP2_ENST00000409195.1_3'UTR|XIRP2_ENST00000409605.1_Silent_p.A294A|XIRP2_ENST00000409756.2_Silent_p.A516A|XIRP2_ENST00000420519.1_Silent_p.A549A	NM_001199143.1	NP_001186072.1	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						ATTTAGATGCTGGTAACAGTG	0.383000													14	74					0	0	0.024245	0	0
IGFL3	388555	broad.mit.edu	37	19	46627241	46627241	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:46627241G>T	ENST00000341415.2	-	3	276	c.252C>A	c.(250-252)ccC>ccA	p.P84P	AC007193.6_ENST00000597989.1_lincRNA	NM_207393.1	NP_997276.1	Q6UXB1	IGFL3_HUMAN	IGF-like family member 3	84						extracellular region	protein binding	p.P84P(1)		endometrium(1)|large_intestine(1)|lung(5)	7		Ovarian(192;0.0175)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00473)|GBM - Glioblastoma multiforme(486;0.0149)|Epithelial(262;0.239)		CAAAAGACTCGGGACAGCAGA	0.537000													69	110					2.26907e-38	4.9613e-38	0.014410	1	0
PGBD4	161779	broad.mit.edu	37	15	34396468	34396468	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:34396468A>T	ENST00000397766.2	+	1	2195	c.1736A>T	c.(1735-1737)tAc>tTc	p.Y579F		NM_152595.4	NP_689808.2	Q96DM1	PGBD4_HUMAN	piggyBac transposable element derived 4	579										breast(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|pancreas(1)|prostate(1)	16		all_lung(180;1.76e-08)		all cancers(64;1.22e-17)|GBM - Glioblastoma multiforme(113;1.78e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0242)		TTTGAAATTTACCACACGAAA	0.393000													21	50					0	0	0.016522	0	0
TECPR2	9895	broad.mit.edu	37	14	102891368	102891368	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:102891368C>G	ENST00000359520.7	+	6	917	c.691C>G	c.(691-693)Cta>Gta	p.L231V	TECPR2_ENST00000558678.1_Missense_Mutation_p.L231V|TECPR2_ENST00000561228.1_3'UTR	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	231							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						GCAAAGTGATCTAACCTTGTA	0.448000													29	77					0	0	0.015359	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900060	151900060	+	Silent	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:151900060G>C	ENST00000393900.3	-	3	1094	c.741C>G	c.(739-741)acC>acG	p.T247T	MAGEA12_ENST00000357916.4_Silent_p.T247T|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Silent_p.T247T	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	247	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CCAAATCTTGGGTGAGCAGCT	0.572000													51	192					0	0	0.014410	0	0
ABCA10	10349	broad.mit.edu	37	17	67197703	67197703	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:67197703C>A	ENST00000269081.4	-	11	2022	c.1113G>T	c.(1111-1113)gaG>gaT	p.E371D	ABCA10_ENST00000416101.2_Missense_Mutation_p.E371D|ABCA10_ENST00000432313.2_Missense_Mutation_p.E371D	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	371					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					CAGAGGAATGCTCAGGATTTA	0.358000													14	52					1.49906e-05	1.91609e-05	0.020292	1	0
CASQ2	845	broad.mit.edu	37	1	116269693	116269693	+	Silent	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:116269693T>C	ENST00000261448.5	-	6	896	c.657A>G	c.(655-657)ccA>ccG	p.P219P	CASQ2_ENST00000488931.1_5'UTR|CASQ2_ENST00000456138.2_Silent_p.P148P	NM_001232.3	NP_001223.2	O14958	CASQ2_HUMAN	calsequestrin 2 (cardiac muscle)	219					heart development|striated muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|skin(1)	18	Lung SC(450;0.211)	all_cancers(81;1.25e-06)|all_epithelial(167;1.02e-06)|all_lung(203;8.03e-06)|Lung NSC(69;5.01e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		CATCCATAAATGGCTCATAGA	0.403000													6	37					0	0	0.021553	0	0
NMS	129521	broad.mit.edu	37	2	101097619	101097619	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:101097619T>G	ENST00000376865.1	+	8	411	c.404T>G	c.(403-405)tTc>tGc	p.F135C		NM_001011717.1	NP_001011717.1	Q5H8A3	NMS_HUMAN	neuromedin S	135					neuropeptide signaling pathway|regulation of smooth muscle contraction	extracellular region				breast(1)|large_intestine(4)|lung(7)|ovary(1)|stomach(1)	14						CGACCCTTTTTCCTTTTCAGG	0.438000													34	114					0	0	0.015359	0	0
KBTBD2	25948	broad.mit.edu	37	7	32909054	32909054	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:32909054T>A	ENST00000304056.4	-	4	2474	c.1775A>T	c.(1774-1776)gAa>gTa	p.E592V	AVL9_ENST00000404479.1_Intron	NM_015483.2	NP_056298.2	Q8IY47	KBTB2_HUMAN	kelch repeat and BTB (POZ) domain containing 2	592										endometrium(3)|kidney(3)|large_intestine(3)|lung(7)|urinary_tract(1)	17			GBM - Glioblastoma multiforme(11;0.0499)			TGGAGACTCTTCAAGGCAGGA	0.483000													29	84					0	0	0.034045	0	0
DMGDH	29958	broad.mit.edu	37	5	78328549	78328549	+	Missense_Mutation	SNP	G	G	T	rs148916205	byFrequency	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:78328549G>T	ENST00000255189.3	-	9	1506	c.1478C>A	c.(1477-1479)cCg>cAg	p.P493Q	DMGDH_ENST00000380311.4_Missense_Mutation_p.P292Q|DMGDH_ENST00000540686.1_Missense_Mutation_p.P113Q	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	493					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		GAACCAGTGCGGCTGCTCCCA	0.562000													48	119					2.29192e-23	4.68019e-23	0.014410	1	0
ISY1-RAB43	100534599	broad.mit.edu	37	3	128852984	128852984	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:128852984C>T	ENST00000418265.1	-	9	656	c.596G>A	c.(595-597)aGa>aAa	p.R199K	ISY1_ENST00000273541.8_Missense_Mutation_p.R221K|ISY1_ENST00000393295.3_Missense_Mutation_p.R199K|ISY1_ENST00000393292.3_Silent_p.K200K|ISY1_ENST00000471497.1_Intron	NM_001204890.1	NP_001191819.1	Q9ULR0	ISY1_HUMAN		199						catalytic step 2 spliceosome											ctTTTCTCCTCTTGCCAGCCG	0.512000													8	75					0	0	0.004482	0	0
PTCHD4	442213	broad.mit.edu	37	6	47847065	47847065	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:47847065G>T	ENST00000339488.4	-	3	1548	c.1515C>A	c.(1513-1515)gcC>gcA	p.A505A		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	505						integral to membrane	hedgehog receptor activity										GCTGAACCATGGCATAGGAAA	0.468000													9	25					1.12685e-05	1.46233e-05	0.004482	1	0
SPEG	10290	broad.mit.edu	37	2	220332025	220332025	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:220332025G>T	ENST00000312358.7	+	10	3143	c.3011G>T	c.(3010-3012)cGt>cTt	p.R1004L	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1004	Ig-like 4.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity	p.R1004L(1)		breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TGGCTGTGCCGTGGCCGCCTG	0.627000													16	64					6.72482e-11	1.09399e-10	0.024245	1	0
ZNF791	163049	broad.mit.edu	37	19	12740052	12740052	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:12740052A>G	ENST00000343325.4	+	4	1871	c.1709A>G	c.(1708-1710)cAt>cGt	p.H570R	ZNF791_ENST00000540038.1_Missense_Mutation_p.H461R|ZNF791_ENST00000446165.1_3'UTR|ZNF791_ENST00000458122.3_Missense_Mutation_p.H538R|ZNF490_ENST00000465656.1_Intron	NM_153358.2	NP_699189.2	Q3KP31	ZN791_HUMAN	zinc finger protein 791	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(3)	19						TTAAAAAAACATATGAGAATG	0.333000													18	42					0	0	0.010504	0	0
RBM41	55285	broad.mit.edu	37	X	106331911	106331911	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:106331911C>G	ENST00000372487.1	-	5	708	c.682G>C	c.(682-684)Ggc>Cgc	p.G228R	RBM41_ENST00000372479.3_Missense_Mutation_p.G228R|RBM41_ENST00000203616.8_Intron	NM_001171080.1	NP_001164551.1	Q96IZ5	RBM41_HUMAN	RNA binding motif protein 41	228							nucleotide binding|RNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	13						TCAGCTGTGCCACTATCACCC	0.463000													15	57					0	0	0.033300	0	0
MAT1A	4143	broad.mit.edu	37	10	82036222	82036222	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:82036222G>T	ENST00000372213.3	-	6	938	c.678C>A	c.(676-678)gtC>gtA	p.V226V		NM_000429.2	NP_000420.1	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	226					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity			endometrium(4)|large_intestine(7)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	CGGCCCTGATGACTTGCTCCT	0.607000													21	78					4.96729e-08	7.32702e-08	0.008871	1	0
SP8	221833	broad.mit.edu	37	7	20825372	20825372	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:20825372C>A	ENST00000361443.4	-	3	247	c.10G>T	c.(10-12)Gct>Tct	p.A4S	SP8_ENST00000418710.2_Missense_Mutation_p.A22S	NM_198956.2	NP_945194.1	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	8						TTACAGGTAGCGGCAAGCATG	0.627000													18	31					1.67942e-08	2.54344e-08	0.006122	1	0
KRT73	319101	broad.mit.edu	37	12	53007601	53007601	+	Silent	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:53007601C>G	ENST00000305748.3	-	5	889	c.855G>C	c.(853-855)acG>acC	p.T285T	RP11-641A6.2_ENST00000549180.1_RNA|RP11-641A6.2_ENST00000552364.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	285	Linker 12.|Rod.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		GGATGATGGACGTGTCGCTGA	0.557000													18	90					0	0	0.008871	0	0
ZNF592	9640	broad.mit.edu	37	15	85345402	85345402	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:85345402G>T	ENST00000299927.3	+	8	3604	c.3582G>T	c.(3580-3582)atG>atT	p.M1194I	ZNF592_ENST00000560079.2_Missense_Mutation_p.M1194I			Q92610	ZN592_HUMAN	zinc finger protein 592	1194					cell death|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	40			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CAGCGGAGATGGCAGTGGAGG	0.622000													5	13					1.23904e-05	1.58971e-05	0.014758	1	0
ITGA6	3655	broad.mit.edu	37	2	173352049	173352049	+	Silent	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:173352049A>T	ENST00000375221.2	+	16	2348	c.2145A>T	c.(2143-2145)atA>atT	p.I715I	ITGA6_ENST00000264106.6_Silent_p.I715I|ITGA6_ENST00000409532.1_Silent_p.I557I|ITGA6_ENST00000264107.7_Silent_p.I676I|ITGA6_ENST00000409080.1_Silent_p.I676I|ITGA6_ENST00000343713.4_Silent_p.I671I|AC093818.1_ENST00000442417.1_RNA			P23229	ITA6_HUMAN	integrin, alpha 6	715					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			CTTTAGAAATAACAGTGACAA	0.388000													20	61					0	0	0.007413	0	0
RYR2	6262	broad.mit.edu	37	1	237923132	237923132	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:237923132C>T	ENST00000366574.2	+	83	11699	c.11382C>T	c.(11380-11382)gcC>gcT	p.A3794A	RYR2_ENST00000542537.1_Silent_p.A3778A|RYR2_ENST00000360064.6_Silent_p.A3800A	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3794					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGAGCCTGGCCGGCCTGATGC	0.433000													18	71					0	0	0.012319	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127989	117127989	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:117127989C>T	ENST00000310357.3	-	3	900	c.879G>A	c.(877-879)atG>atA	p.M293I	GPRC6A_ENST00000368549.3_Missense_Mutation_p.M293I|GPRC6A_ENST00000530250.1_Intron	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	293					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TATTTATATTCATTTCAATGG	0.353000													5	94					0	0	0.014758	0	0
SUN3	256979	broad.mit.edu	37	7	48026950	48026950	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:48026950C>A	ENST00000453192.2	-	11	1258	c.1015G>T	c.(1015-1017)Ggc>Tgc	p.G339C	SUN3_ENST00000395572.2_Missense_Mutation_p.G351C|SUN3_ENST00000297325.4_Missense_Mutation_p.G351C|SUN3_ENST00000473723.1_5'UTR|SUN3_ENST00000412142.1_Missense_Mutation_p.G263C			Q8TAQ9	SUN3_HUMAN	Sad1 and UNC84 domain containing 3	351	SUN.					integral to membrane				central_nervous_system(1)|endometrium(3)|large_intestine(8)|liver(1)|lung(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CCTGGTGTGCCATGGACCCTG	0.413000													32	146					6.97489e-18	1.359e-17	0.021022	1	0
KIF13A	63971	broad.mit.edu	37	6	17781518	17781518	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:17781518C>A	ENST00000378814.5	-	29	3519	c.3520G>T	c.(3520-3522)Gcc>Tcc	p.A1174S	KIF13A_ENST00000378816.5_Missense_Mutation_p.A1187S|KIF13A_ENST00000259711.6_Missense_Mutation_p.A1187S|KIF13A_ENST00000378843.2_Missense_Mutation_p.A1174S|KIF13A_ENST00000378826.2_Missense_Mutation_p.A1187S	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	1187					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			TGCTCATTGGCACTGAGGTCA	0.463000													7	51					7.48243e-07	1.03838e-06	0.006214	1	0
AKR1B15	441282	broad.mit.edu	37	7	134260652	134260652	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:134260652G>T	ENST00000457545.2	+	8	976	c.716G>T	c.(715-717)aGc>aTc	p.S239I	AKR1B15_ENST00000423958.1_Missense_Mutation_p.S211I	NM_001080538.2	NP_001074007.2	C9JRZ8	AK1BF_HUMAN	aldo-keto reductase family 1, member B15	239							oxidoreductase activity			endometrium(1)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|urinary_tract(1)	18						ACGGCCTACAGCCCCCTGGGC	0.483000													8	44					2.17888e-05	2.74377e-05	0.006214	1	0
LINC00521	256369	broad.mit.edu	37	14	94467727	94467727	+	RNA	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:94467727G>T	ENST00000444118.1	+	0	805					NR_024182.1																						GGGGGCGTGGGGCCCCCTTTC	0.657000													4	6					0.000602214	0.000698815	0.014758	1	0
CYP19A1	1588	broad.mit.edu	37	15	51514613	51514613	+	Silent	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:51514613C>G	ENST00000396402.1	-	5	714	c.561G>C	c.(559-561)gtG>gtC	p.V187V	RP11-108K3.1_ENST00000559909.1_lincRNA|CYP19A1_ENST00000396404.4_Silent_p.V187V|CYP19A1_ENST00000405913.3_Silent_p.V187V|CYP19A1_ENST00000260433.2_Silent_p.V187V|CYP19A1_ENST00000557858.1_Silent_p.V187V|CYP19A1_ENST00000559878.1_Silent_p.V187V	NM_000103.3	NP_000094.2	P11511	CP19A_HUMAN	cytochrome P450, family 19, subfamily A, polypeptide 1	187					estrogen biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|membrane fraction	aromatase activity|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			endometrium(1)|kidney(4)|large_intestine(9)|lung(11)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	33				all cancers(107;0.000372)|GBM - Glioblastoma multiforme(94;0.0128)	Aminoglutethimide(DB00357)|Anastrozole(DB01217)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Diethylstilbestrol(DB00255)|Exemestane(DB00990)|Letrozole(DB01006)|Testolactone(DB00894)|Testosterone(DB00624)	GAAGGGTCAACACGTCCACAT	0.512000													10	39					0	0	0.010729	0	0
CINP	51550	broad.mit.edu	37	14	102829188	102829188	+	Translation_Start_Site	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:102829188T>C	ENST00000216756.6	-	1	41	c.1A>G	c.(1-3)Atg>Gtg	p.M1V	CINP_ENST00000541568.2_Start_Codon_SNP_p.M1V	NM_032630.2	NP_116019.1	Q9BW66	CINP_HUMAN	cyclin-dependent kinase 2 interacting protein	1					cell cycle|cell division|DNA repair|DNA replication	nucleus	protein binding			large_intestine(2)|lung(2)	4						GCACCTTCCATAAGGTCCACA	0.622000													5	34					0	0	0.014758	0	0
WTAP	9589	broad.mit.edu	37	6	160176510	160176510	+	Nonsense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:160176510C>G	ENST00000358372.4	+	8	2815	c.1058C>G	c.(1057-1059)tCa>tGa	p.S353*	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	353					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		ACACACCAATCAAATGACACA	0.502000													13	90					0	0	0.013537	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84607683	84607683	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:84607683G>A	ENST00000344803.2	+	4	2345	c.2298G>A	c.(2296-2298)atG>atA	p.M766I		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		TGCTTTCCATGGAGAATGTGG	0.473000													9	41					0	0	0.008291	0	0
DDX26B	203522	broad.mit.edu	37	X	134713926	134713926	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:134713926G>T	ENST00000370752.4	+	15	2556	c.2222G>T	c.(2221-2223)gGa>gTa	p.G741V	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	741										large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					TTTGTAGGAGGAGCCAAAAAC	0.453000													13	48					0.00136819	0.00155321	0.013537	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140774427	140774427	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:140774427G>T	ENST00000398604.2	+	1	2047	c.2047G>T	c.(2047-2049)Gac>Tac	p.D683Y	PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB4_ENST00000519479.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCTTCGGTCGACCCGAACGA	0.617000													7	17					2.0095e-06	2.71123e-06	0.029380	1	0
ROS1	6098	broad.mit.edu	37	6	117632220	117632220	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:117632220C>A	ENST00000368508.3	-	39	6394	c.6196G>T	c.(6196-6198)Ggc>Tgc	p.G2066C	ROS1_ENST00000368507.3_Missense_Mutation_p.G2060C	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2066	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TAGACACAGCCTTTTGAAATA	0.378000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								14	67					3.45872e-05	4.31546e-05	0.028581	1	0
FRMD3	257019	broad.mit.edu	37	9	85926824	85926824	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:85926824T>A	ENST00000304195.3	-	8	957	c.751A>T	c.(751-753)Aag>Tag	p.K251*	FRMD3_ENST00000376434.1_Nonsense_Mutation_p.K57*|FRMD3_ENST00000376438.1_Nonsense_Mutation_p.K251*	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	251	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						TGGATTCTCTTATTTCCCTGA	0.383000													8	38					0	0	0.016522	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37490239	37490239	+	Missense_Mutation	SNP	G	G	A	rs137903346	by1000genomes	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:37490239G>A	ENST00000374660.1	+	37	3143	c.3044G>A	c.(3043-3045)aGt>aAt	p.S1015N	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.S896N|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.S896N			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1037						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GATAAAATAAGTGGAAAATTA	0.328000													10	37					0	0	0.010729	0	0
LPHN3	23284	broad.mit.edu	37	4	62598770	62598770	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:62598770T>G	ENST00000512091.1	+	7	1440	c.693T>G	c.(691-693)ttT>ttG	p.F231L	LPHN3_ENST00000514996.1_Missense_Mutation_p.F231L|LPHN3_ENST00000506746.1_Missense_Mutation_p.F299L|LPHN3_ENST00000507625.1_Missense_Mutation_p.F299L|LPHN3_ENST00000514591.1_Missense_Mutation_p.F231L|LPHN3_ENST00000545650.1_Missense_Mutation_p.F231L|LPHN3_ENST00000507164.1_Missense_Mutation_p.F299L|LPHN3_ENST00000514157.1_Missense_Mutation_p.F231L|LPHN3_ENST00000511324.1_Missense_Mutation_p.F299L|LPHN3_ENST00000506700.1_Missense_Mutation_p.F231L|LPHN3_ENST00000508693.1_Missense_Mutation_p.F299L|LPHN3_ENST00000506720.1_Missense_Mutation_p.F299L|LPHN3_ENST00000508946.1_Missense_Mutation_p.F231L|LPHN3_ENST00000504896.1_Missense_Mutation_p.F231L|LPHN3_ENST00000509896.1_Missense_Mutation_p.F299L			Q9HAR2	LPHN3_HUMAN	latrophilin 3	231	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TAGTAAAGTTTGATTTGCGGA	0.463000													9	19					0	0	0.008291	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76513435	76513435	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:76513435G>T	ENST00000307431.8	+	13	2264	c.1879_splice	c.e13+1	p.E627_splice	CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Splice_Site_p.E579_splice|CNTNAP4_ENST00000478060.1_Splice_Site_p.E555_splice|CNTNAP4_ENST00000476707.1_Splice_Site_p.E631_splice	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	628	Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CAATATGACCGGTGAGTTAAT	0.333000													21	62					1.00905e-13	1.80566e-13	0.008871	1	0
CLCN1	1180	broad.mit.edu	37	7	143029957	143029957	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:143029957C>A	ENST00000343257.2	+	12	1479	c.1392C>A	c.(1390-1392)ttC>ttA	p.F464L		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	464					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					TTCTCTTCTTCGTCATGAAGG	0.502000													41	114					3.38236e-24	6.99089e-24	0.027894	1	0
PJA1	64219	broad.mit.edu	37	X	68382632	68382632	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:68382632C>A	ENST00000361478.1	-	2	827	c.450G>T	c.(448-450)aaG>aaT	p.K150N	PJA1_ENST00000477231.1_5'UTR|PJA1_ENST00000374571.4_Missense_Mutation_p.K95N|PJA1_ENST00000374583.1_Missense_Mutation_p.K150N|PJA1_ENST00000374584.3_Intron	NM_001032396.2|NM_022368.4|NM_145119.3	NP_001027568.1|NP_071763.2|NP_660095.1	Q8NG27	PJA1_HUMAN	praja ring finger 1, E3 ubiquitin protein ligase	150							zinc ion binding			endometrium(3)|large_intestine(5)|lung(12)|ovary(1)	21						GGTCATACAGCTTATCATCTT	0.512000													8	18					0.000157383	0.000186772	0.003080	1	0
WDR7	23335	broad.mit.edu	37	18	54361959	54361959	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr18:54361959C>T	ENST00000254442.3	+	10	1287	c.1076C>T	c.(1075-1077)tCa>tTa	p.S359L	WDR7_ENST00000357574.3_Missense_Mutation_p.S359L|WDR7_ENST00000589935.1_Intron	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	359										NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		TGGAACATATCAGACACAGCT	0.328000													7	27					0	0	0.004482	0	0
AHNAK	79026	broad.mit.edu	37	11	62299271	62299271	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:62299271C>A	ENST00000378024.4	-	5	2892	c.2618G>T	c.(2617-2619)tGg>tTg	p.W873L	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	873					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTTCAGGTGCCAGTCTGGGCC	0.483000													122	262					7.54917e-67	1.67213e-66	0.014410	1	0
NPTX2	4885	broad.mit.edu	37	7	98254454	98254454	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:98254454C>A	ENST00000265634.3	+	3	1029	c.864C>A	c.(862-864)ccC>ccA	p.P288P		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	288	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GCAACAACCCCATCGAGCTGC	0.667000													11	57					1.08611e-07	1.57139e-07	0.010729	1	0
BAZ1A	11177	broad.mit.edu	37	14	35243648	35243648	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:35243648G>T	ENST00000360310.1	-	19	3449	c.2882C>A	c.(2881-2883)tCc>tAc	p.S961Y	BAZ1A_ENST00000358716.4_Missense_Mutation_p.S929Y|BAZ1A_ENST00000382422.2_Missense_Mutation_p.S961Y	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	961					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		ATATGCATTGGAAGATCTTCC	0.333000													16	93					5.03518e-11	8.25042e-11	0.007413	1	0
NTRK3	4916	broad.mit.edu	37	15	88680653	88680653	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:88680653T>A	ENST00000394480.1	-	7	925	c.604A>T	c.(604-606)Atg>Ttg	p.M202L	NTRK3_ENST00000540489.2_Missense_Mutation_p.M202L|NTRK3_ENST00000360948.2_Missense_Mutation_p.M202L|NTRK3_ENST00000357724.2_Missense_Mutation_p.M202L|NTRK3_ENST00000355254.2_Missense_Mutation_p.M202L|NTRK3_ENST00000542733.2_Missense_Mutation_p.M104L|NTRK3_ENST00000557856.1_Missense_Mutation_p.M202L|NTRK3_ENST00000558676.1_Missense_Mutation_p.M202L|NTRK3_ENST00000317501.3_Missense_Mutation_p.M202L	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	202	LRRCT.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGATGTTCATGCGGAAGAGA	0.612000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			6	29					0	0	0.029380	0	0
UGT2B17	7367	broad.mit.edu	37	4	69433871	69433871	+	Nonsense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:69433871G>C	ENST00000317746.2	-	1	374	c.332C>G	c.(331-333)tCa>tGa	p.S111*		NM_001077.3	NP_001068.1	O75795	UDB17_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B17	111					steroid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(14)|ovary(2)|prostate(1)	30						TTGTAGTTGTGAAAAATATGA	0.279000													33	43					0	0	0.012213	0	0
FAM83D	81610	broad.mit.edu	37	20	37576645	37576645	+	Splice_Site	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:37576645T>A	ENST00000217429.4	+	3	907		c.e3+2			NM_030919.2	NP_112181.2	Q9H4H8	FA83D_HUMAN	family with sequence similarity 83, member D						cell division|mitosis	cytoplasm|spindle pole				endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(4)|stomach(1)	28		Myeloproliferative disorder(115;0.00878)				CTCCTACAGGTAAGTCTCTAA	0.433000													15	60					0	0	0.024245	0	0
PXK	54899	broad.mit.edu	37	3	58385031	58385031	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:58385031G>T	ENST00000463280.1	+	10	1100	c.1009G>T	c.(1009-1011)Gtg>Ttg	p.V337L	PXK_ENST00000383716.3_Missense_Mutation_p.V337L|PXK_ENST00000302779.5_Missense_Mutation_p.V353L|PXK_ENST00000356151.2_Missense_Mutation_p.V370L|PXK_ENST00000479241.1_Missense_Mutation_p.V353L|PXK_ENST00000484288.1_Missense_Mutation_p.V370L|PXK_ENST00000383715.4_Missense_Mutation_p.V353L|PXK_ENST00000536660.1_Missense_Mutation_p.V233L			Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	370	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		TCAAGTGGCCGTGTTGGAGTC	0.438000													6	31					3.59834e-05	4.45696e-05	0.021553	1	0
TRBV4-2	28616	broad.mit.edu	37	7	142045406	142045406	+	RNA	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:142045406G>T	ENST00000390392.3	+	0	155																											TGTCTCCTGGGAGCGGGTGAG	0.567000													13	215					1.33834e-09	2.11644e-09	0.007413	1	0
ADCY1	107	broad.mit.edu	37	7	45650001	45650001	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:45650001G>T	ENST00000297323.7	+	3	835	c.813G>T	c.(811-813)ctG>ctT	p.L271L	ADCY1_ENST00000432715.1_Silent_p.L46L	NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	271					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	TGAGCCTCCTGCCCCGGAACG	0.592000													22	95					2.39556e-15	4.46297e-15	0.016522	1	0
FPGT	8790	broad.mit.edu	37	1	74671407	74671407	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:74671407A>G	ENST00000370898.2	+	4	1713	c.1676A>G	c.(1675-1677)tAt>tGt	p.Y559C	FPGT-TNNI3K_ENST00000370895.1_Intron|TNNI3K_ENST00000370891.2_Intron|TNNI3K_ENST00000370893.1_Intron|FPGT-TNNI3K_ENST00000557284.1_Intron|FPGT_ENST00000534056.1_Missense_Mutation_p.Y305C|FPGT_ENST00000370894.4_3'UTR|FPGT-TNNI3K_ENST00000370899.3_Intron|FPGT_ENST00000524915.1_Intron	NM_001199328.1|NM_003838.3	NP_001186257.1|NP_003829.2			fucose-1-phosphate guanylyltransferase											breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(18)|ovary(1)|prostate(4)|skin(1)|urinary_tract(1)	39						CTGAATAGCTATAAGTTGCTG	0.338000													15	61					0	0	0.028581	0	0
ZNF711	7552	broad.mit.edu	37	X	84510461	84510461	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:84510461G>T	ENST00000360700.4	+	4	1162	c.276G>T	c.(274-276)gcG>gcT	p.A92A	ZNF711_ENST00000395402.1_Silent_p.A70A|ZNF711_ENST00000373165.3_Silent_p.A92A|ZNF711_ENST00000276123.3_Silent_p.A92A			Q9Y462	ZN711_HUMAN	zinc finger protein 711	92					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TTCCTGAAGCGGTACTTGAAG	0.433000													48	126					1.00953e-15	1.91754e-15	0.013114	1	0
HIST2H2BB	338391	broad.mit.edu	37	1	149375049	149375049	+	RNA	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:149375049T>C	ENST00000415338.1	-	0	1061																											GGAGAACCTCTGGCCTTGAGG	0.458000													29	90					0	0	0.013726	0	0
CPED1	79974	broad.mit.edu	37	7	120911459	120911459	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:120911459G>A	ENST00000310396.5	+	22	3310	c.2843G>A	c.(2842-2844)gGg>gAg	p.G948E		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		TTTCTACAGGGGAAGTGTGGA	0.323000													27	125					0	0	0.024334	0	0
ABCG8	64241	broad.mit.edu	37	2	44079588	44079588	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:44079588G>T	ENST00000272286.2	+	5	747	c.657G>T	c.(655-657)agG>agT	p.R219S		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	219	ABC transporter.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GTGAGCGCAGGAGAGTCAGCA	0.677000													5	53					0.0215528	0.0228285	0.021553	1	0
MAGEA10	4109	broad.mit.edu	37	X	151303839	151303839	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:151303839T>A	ENST00000370323.4	-	4	570	c.254A>T	c.(253-255)cAg>cTg	p.Q85L	MAGEA10_ENST00000244096.3_Missense_Mutation_p.Q85L|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	85										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CTGAGCACTCTGGGGAGGATT	0.547000													48	162					0	0	0.014410	0	0
HIST1H2BL	8340	broad.mit.edu	37	6	27775425	27775425	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:27775425C>G	ENST00000377401.2	-	1	284	c.260G>C	c.(259-261)cGc>cCc	p.R87P		NM_003519.3	NP_003510.1	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl	87					nucleosome assembly	nucleosome|nucleus	DNA binding			cervix(1)|endometrium(1)|large_intestine(2)|lung(7)|urinary_tract(1)	12						GATGGTCGAGCGCTTGTTGTA	0.632000													23	132					0	0	0.021523	0	0
PGBD5	79605	broad.mit.edu	37	1	230492930	230492930	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:230492930C>A	ENST00000321327.2	-	4	558	c.559G>T	c.(559-561)Gga>Tga	p.G187*	PGBD5_ENST00000525115.1_Nonsense_Mutation_p.G88*|PGBD5_ENST00000391860.1_Nonsense_Mutation_p.G42*			Q8N414	PGBD5_HUMAN	piggyBac transposable element derived 5	88						integral to membrane				biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(2)|skin(1)	33	Breast(184;0.0397)	Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;0.201)		ACCCAGGCTCCGTCGCTCCCA	0.567000													11	50					0.00010058	0.000120838	0.013537	1	0
PRDM14	63978	broad.mit.edu	37	8	70981559	70981559	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:70981559C>A	ENST00000276594.2	-	2	738	c.537G>T	c.(535-537)gaG>gaT	p.E179D		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			TGGGACCATCCTCTGACTGCT	0.577000													9	25					0.00448238	0.00494808	0.004482	1	0
PCDH7	5099	broad.mit.edu	37	4	30726008	30726008	+	Silent	SNP	C	C	A	rs148242685		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:30726008C>A	ENST00000361762.2	+	1	3972	c.2964C>A	c.(2962-2964)ggC>ggA	p.G988G	PCDH7_ENST00000543491.1_Silent_p.G988G	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	988					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						GTGGGCCCGGCAGTCCTGACC	0.517000													8	63					0.00307968	0.00343872	0.003080	1	0
PTBP1	5725	broad.mit.edu	37	19	810798	810798	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:810798G>C	ENST00000356948.6	+	15	2069	c.1646G>C	c.(1645-1647)cGg>cCg	p.R549P	PTBP1_ENST00000394601.4_Missense_Mutation_p.R542P|PTBP1_ENST00000350092.4_Missense_Mutation_p.R189P|PTBP1_ENST00000349038.4_Missense_Mutation_p.R523P	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1	523					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCACCTGCGGGTCTCCTTC	0.612000													12	72					0	0	0.020292	0	0
NAA15	80155	broad.mit.edu	37	4	140291518	140291518	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:140291518G>T	ENST00000296543.5	+	15	2230	c.1907G>T	c.(1906-1908)gGa>gTa	p.G636V	NAA15_ENST00000398947.1_Missense_Mutation_p.G636V	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	636					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						gaggagataggaggtccaaaa	0.358000													5	27					1.23904e-05	1.58971e-05	0.014758	1	0
OR11G2	390439	broad.mit.edu	37	14	20665591	20665591	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:20665591A>T	ENST00000357366.3	+	1	97	c.97A>T	c.(97-99)Agg>Tgg	p.R33W		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TACAATTCACAGGCACATGAA	0.448000													6	22					0	0	0.029380	0	0
GOLGB1	2804	broad.mit.edu	37	3	121413027	121413027	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:121413027C>T	ENST00000393667.3	-	13	6453	c.6343G>A	c.(6343-6345)Gaa>Aaa	p.E2115K	GOLGB1_ENST00000340645.5_Missense_Mutation_p.E2110K	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	2110					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TTAACTGATTCTTTATTTGAC	0.403000													11	195					0	0	0.013537	0	0
KMT2D	8085	broad.mit.edu	37	12	49433751	49433751	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:49433751G>A	ENST00000301067.7	-	31	7801	c.7802C>T	c.(7801-7803)aCa>aTa	p.T2601I		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GCTCTCCCCTGTGGACCCGCT	0.662000													7	13					0	0	0.004482	0	0
NXF3	56000	broad.mit.edu	37	X	102333559	102333559	+	Splice_Site	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:102333559C>A	ENST00000395065.3	-	17	1481	c.1378_splice	c.e17-1	p.V460_splice	NXF3_ENST00000425644.1_Splice_Site_p.V132_splice|NXF3_ENST00000497850.1_5'UTR	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	460	NTF2.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						ACTGTCCTTCCACTTCAAAGA	0.517000													7	186					0.00448238	0.00494808	0.004482	1	0
TLL2	7093	broad.mit.edu	37	10	98129868	98129868	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:98129868C>A	ENST00000357947.3	-	20	3092	c.2867G>T	c.(2866-2868)gGc>gTc	p.G956V		NM_012465.3	NP_036597.1	Q9Y6L7	TLL2_HUMAN	tolloid-like 2	956	CUB 5.				cell differentiation|multicellular organismal development|proteolysis	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(15)|lung(22)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	58		Colorectal(252;0.0846)		Epithelial(162;1.51e-07)|all cancers(201;7.59e-06)		GCTGTCGTAGCCGTCGTAGGC	0.637000													9	41					2.17888e-05	2.74377e-05	0.006214	1	0
NLRP3	114548	broad.mit.edu	37	1	247587867	247587867	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:247587867C>A	ENST00000366497.2	+	4	1902	c.1122C>A	c.(1120-1122)tcC>tcA	p.S374S	NLRP3_ENST00000336119.3_Silent_p.S374S|NLRP3_ENST00000348069.2_Silent_p.S374S|NLRP3_ENST00000391827.2_Silent_p.S374S|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000391828.3_Silent_p.S374S|NLRP3_ENST00000366496.2_Silent_p.S374S	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	374	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGGGTTTCTCCGAGGCCAAAA	0.552000													21	61					4.96729e-08	7.32702e-08	0.008871	1	0
CLIC2	1193	broad.mit.edu	37	X	154508456	154508456	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:154508456G>T	ENST00000369449.2	-	5	782	c.564C>A	c.(562-564)ccC>ccA	p.P188P	CLIC2_ENST00000465553.1_5'UTR	NM_001289.4	NP_001280.3	O15247	CLIC2_HUMAN	chloride intracellular channel 2	188	C-terminal.|GST C-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	voltage-gated chloride channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|skin(1)	18	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGTTCAGCTTGGGTAACAAGC	0.478000													6	133					0.00116845	0.00132867	0.021553	1	0
SLC38A6	145389	broad.mit.edu	37	14	61451499	61451499	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:61451499G>T	ENST00000354886.2	+	3	452	c.288G>T	c.(286-288)ctG>ctT	p.L96L	SLC38A6_ENST00000456840.2_Silent_p.L73L|SLC38A6_ENST00000554304.1_3'UTR|SLC38A6_ENST00000267488.4_Silent_p.L96L	NM_001172702.1	NP_001166173.1	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	96					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(2)|lung(5)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TCCATCTTCTGCTTAGTATGT	0.383000													20	77					2.39556e-15	4.46297e-15	0.016522	1	0
SLC4A7	9497	broad.mit.edu	37	3	27473031	27473031	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:27473031G>A	ENST00000295736.5	-	7	951	c.881C>T	c.(880-882)cCt>cTt	p.P294L	SLC4A7_ENST00000446700.1_Missense_Mutation_p.P286L|SLC4A7_ENST00000425128.2_Missense_Mutation_p.P286L|SLC4A7_ENST00000454389.1_Missense_Mutation_p.P303L|SLC4A7_ENST00000388777.4_5'UTR|SLC4A7_ENST00000437179.1_Intron|SLC4A7_ENST00000435667.2_Intron|SLC4A7_ENST00000428386.1_Intron|SLC4A7_ENST00000455077.1_Intron|SLC4A7_ENST00000445684.1_Missense_Mutation_p.P290L|SLC4A7_ENST00000440156.1_Missense_Mutation_p.P290L	NM_003615.4	NP_003606.3	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 7	294						apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(12)|lung(9)|ovary(4)|skin(1)	38						TGAGCCTGCAGGGGTTCCAGC	0.512000													14	65					0	0	0.016723	0	0
TENM2	57451	broad.mit.edu	37	5	167653121	167653121	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:167653121G>A	ENST00000519204.1	+	23	4892	c.4774G>A	c.(4774-4776)Gtg>Atg	p.V1592M	TENM2_ENST00000518659.1_Missense_Mutation_p.V1713M|TENM2_ENST00000545108.1_Missense_Mutation_p.V1712M|TENM2_ENST00000520394.1_Missense_Mutation_p.V1474M|TENM2_ENST00000403607.2_Missense_Mutation_p.V1537M					teneurin transmembrane protein 2																		CCTGACCAACGTGACGCGCCC	0.527000													4	37					0	0	0.009096	0	0
DGKB	1607	broad.mit.edu	37	7	14758281	14758281	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:14758281G>T	ENST00000403951.2	-	6	771	c.352C>A	c.(352-354)Cct>Act	p.P118T	DGKB_ENST00000399322.3_Missense_Mutation_p.P118T|DGKB_ENST00000407950.1_Missense_Mutation_p.P111T|DGKB_ENST00000403963.1_5'UTR|DGKB_ENST00000406247.3_Missense_Mutation_p.P118T|DGKB_ENST00000402815.1_Missense_Mutation_p.P118T|DGKB_ENST00000258767.5_Missense_Mutation_p.P118T|DGKB_ENST00000444700.2_Missense_Mutation_p.P111T			Q9Y6T7	DGKB_HUMAN	diacylglycerol kinase, beta 90kDa	118					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(34)|ovary(4)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72					Phosphatidylserine(DB00144)	GTCCGGGGAGGGGTGATGGCA	0.383000													11	34					1.58986e-06	2.1579e-06	0.008291	1	0
TIAM1	7074	broad.mit.edu	37	21	32513751	32513751	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr21:32513751C>T	ENST00000286827.3	-	22	4018	c.3547G>A	c.(3547-3549)Gag>Aag	p.E1183K	TIAM1_ENST00000541036.1_Missense_Mutation_p.E1123K	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1183	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						AGGTACGACTCCAGCGTGGAT	0.572000													30	83					0	0	0.012213	0	0
WDR86	349136	broad.mit.edu	37	7	151093213	151093213	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:151093213G>T	ENST00000334493.6	-	3	805	c.375C>A	c.(373-375)gaC>gaA	p.D125E	WDR86_ENST00000469830.2_Missense_Mutation_p.D125E|WDR86_ENST00000477459.1_5'UTR	NM_198285.2	NP_938026.2	Q86TI4	WDR86_HUMAN	WD repeat domain 86	125										breast(1)|endometrium(2)|kidney(1)|lung(6)	10			OV - Ovarian serous cystadenocarcinoma(82;0.00419)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCTGCCCCTTGTCCACACTCC	0.652000													10	41					9.70103e-10	1.54489e-09	0.008291	1	0
ARSH	347527	broad.mit.edu	37	X	2931179	2931179	+	Silent	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:2931179G>C	ENST00000381130.2	+	3	306	c.306G>C	c.(304-306)ctG>ctC	p.L102L		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	102						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				TTGCCAAGCTGCTGCAGCACC	0.562000													11	81					0	0	0.008291	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144882495	144882495	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:144882495C>A	ENST00000369359.4	-	27	3973	c.3935G>T	c.(3934-3936)aGa>aTa	p.R1312I	PDE4DIP_ENST00000369354.3_Missense_Mutation_p.R1175I|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.R1312I|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.R1175I|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1175					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTCTGGGGTCTGGGGAAAGG	0.512000			T	PDGFRB	MPD								10	94					1.58986e-06	2.1579e-06	0.008291	1	0
PIM1	5292	broad.mit.edu	37	6	37138394	37138394	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:37138394G>T	ENST00000373509.5	+	1	416	c.43G>T	c.(43-45)Gcg>Tcg	p.A15S		NM_001243186.1|NM_002648.3	NP_001230115.1|NP_002639.1	P11309	PIM1_HUMAN	pim-1 oncogene	106					cell cycle|cell proliferation|multicellular organismal development|negative regulation of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|protein autophosphorylation	cytoplasm|nucleus|plasma membrane	ATP binding|manganese ion binding|protein binding|protein serine/threonine kinase activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(17)|large_intestine(4)|lung(3)|prostate(2)|skin(2)	30			OV - Ovarian serous cystadenocarcinoma(102;0.241)		Adenosine monophosphate(DB00131)	CCTGCGCGCCGCGCCCTGCAA	0.721000			T	BCL6	NHL								9	35					7.48243e-07	1.03838e-06	0.006214	1	0
BPIFB4	149954	broad.mit.edu	37	20	31695558	31695558	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:31695558G>T	ENST00000375483.3	+	15	1753	c.1753G>T	c.(1753-1755)Ggt>Tgt	p.G585C	BPIFB4_ENST00000494121.1_3'UTR	NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	585						cytoplasm|extracellular region	lipid binding										AGCTGTGCTGGGTTCTGGCGT	0.468000													8	38					7.48243e-07	1.03838e-06	0.006214	1	0
SHOC2	8036	broad.mit.edu	37	10	112745436	112745436	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:112745436C>T	ENST00000369452.4	+	3	1099	c.754C>T	c.(754-756)Cac>Tac	p.H252Y	SHOC2_ENST00000489390.1_Intron|SHOC2_ENST00000265277.5_Intron	NM_007373.3	NP_031399.2	Q9UQ13	SHOC2_HUMAN	soc-2 suppressor of clear homolog (C. elegans)	252					fibroblast growth factor receptor signaling pathway|positive regulation of Ras protein signal transduction|Ras protein signal transduction	nucleus|protein phosphatase type 1 complex	protein phosphatase binding|protein phosphatase regulator activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|skin(2)	17				Epithelial(162;0.000796)|all cancers(201;0.011)|BRCA - Breast invasive adenocarcinoma(275;0.126)		TCAACTTGAACACCTTCCAAA	0.378000													6	70					0	0	0.029380	0	0
SH3TC2	79628	broad.mit.edu	37	5	148408068	148408068	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:148408068C>T	ENST00000515425.1	-	11	1328	c.1227G>A	c.(1225-1227)gaG>gaA	p.E409E	SH3TC2_ENST00000513340.1_5'UTR|SH3TC2_ENST00000394358.2_Silent_p.E294E|SH3TC2_ENST00000512049.1_Silent_p.E402E|SH3TC2_ENST00000538184.1_5'UTR	NM_024577.3	NP_078853.2	Q8TF17	S3TC2_HUMAN	SH3 domain and tetratricopeptide repeats 2	409							binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	39			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTGATGCTCCTCCCAGGCTC	0.622000													11	43					0	0	0.016723	0	0
STAB2	55576	broad.mit.edu	37	12	104089331	104089331	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:104089331C>A	ENST00000388887.2	+	32	3583	c.3379C>A	c.(3379-3381)Ctg>Atg	p.L1127M		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1127	FAS1 3.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						TTTTCAGGTGCTGGTCCCACA	0.468000													6	63					3.59834e-05	4.45696e-05	0.021553	1	0
FAM73A	374986	broad.mit.edu	37	1	78324681	78324681	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:78324681C>T	ENST00000370791.3	+	9	1087	c.1055C>T	c.(1054-1056)cCa>cTa	p.P352L	FAM73A_ENST00000443751.2_Missense_Mutation_p.P314L	NM_001270384.1|NM_198549.3	NP_001257313.1|NP_940951.1	Q8NAN2	FA73A_HUMAN	family with sequence similarity 73, member A	352						integral to membrane				breast(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	19				Colorectal(170;0.226)		TGTCACTGCCCATTTTACGAG	0.423000													15	73					0	0	0.020292	0	0
CACNG3	10368	broad.mit.edu	37	16	24372671	24372671	+	Splice_Site	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:24372671A>T	ENST00000005284.3	+	4	1638		c.e4-1			NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3						regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		CCCTTCTCTTAGGGTTAAGCA	0.428000													27	134					0	0	0.030593	0	0
KRTAP3-3	85293	broad.mit.edu	37	17	39150184	39150184	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:39150184G>T	ENST00000391586.1	-	1	201	c.166C>A	c.(166-168)Cac>Aac	p.H56N		NM_033185.2	NP_149441.1	Q9BYR6	KRA33_HUMAN	keratin associated protein 3-3	56	3 X 5 AA repeats of C-C-X(3).					keratin filament	structural molecule activity			lung(2)|prostate(2)	4		Breast(137;0.00043)				TGAGGAATGTGGCAGGGTGGG	0.617000													27	46					3.6726e-16	7.05472e-16	0.021523	1	0
SP110	3431	broad.mit.edu	37	2	231042313	231042313	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:231042313C>A	ENST00000258381.6	-	14	1608	c.1531G>T	c.(1531-1533)Gca>Tca	p.A511S	SP110_ENST00000258382.5_Missense_Mutation_p.A511S|SP110_ENST00000358662.4_Missense_Mutation_p.A511S|SP110_ENST00000338556.3_Missense_Mutation_p.A213S|SP110_ENST00000392048.3_Missense_Mutation_p.A509S|SP110_ENST00000540870.1_Missense_Mutation_p.A517S	NM_080424.2	NP_536349.2	Q9HB58	SP110_HUMAN	SP110 nuclear body protein	511	SAND.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|signal transducer activity|zinc ion binding			breast(4)|endometrium(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Renal(207;0.0112)|all_lung(227;0.0223)|Lung NSC(271;0.0983)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.169)		Epithelial(121;2.61e-12)|all cancers(144;6.39e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.0097)		CAGTTCTTTGCGTTCCTTCCT	0.428000													40	233					5.71845e-15	1.05381e-14	0.023175	1	0
IL13RA1	3597	broad.mit.edu	37	X	117900509	117900509	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:117900509G>T	ENST00000371666.3	+	7	912	c.845G>T	c.(844-846)tGt>tTt	p.C282F	IL13RA1_ENST00000481868.1_3'UTR	NM_001560.2	NP_001551.1	P78552	I13R1_HUMAN	interleukin 13 receptor, alpha 1	282						interleukin-13 receptor complex	cytokine receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)	12						GAGGCTAAATGTGAGAATCCA	0.338000													5	109					1.23904e-05	1.58971e-05	0.014758	1	0
HIST1H2BK	85236	broad.mit.edu	37	6	27114507	27114507	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:27114507T>A	ENST00000396891.4	-	1	112	c.71A>T	c.(70-72)aAg>aTg	p.K24M	HIST1H2BK_ENST00000356950.1_Missense_Mutation_p.K24M	NM_080593.2	NP_542160.1	O60814	H2B1K_HUMAN	histone cluster 1, H2bk	24					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						GCCGTCCTTCTTCTGCGCCTT	0.602000													24	128					0	0	0.021523	0	0
ZNF536	9745	broad.mit.edu	37	19	31038967	31038967	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:31038967G>T	ENST00000355537.3	+	4	2588	c.2441G>T	c.(2440-2442)gGg>gTg	p.G814V		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	814					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CCGCTGTCTGGGCAACCCCCA	0.572000													35	110					6.53348e-20	1.30286e-19	0.017118	1	0
ARHGAP36	158763	broad.mit.edu	37	X	130218269	130218269	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:130218269C>T	ENST00000276211.5	+	5	981	c.636C>T	c.(634-636)tcC>tcT	p.S212S	ARHGAP36_ENST00000370921.1_Silent_p.S76S|ARHGAP36_ENST00000370922.1_Silent_p.S200S	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	212					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						CAAAAATTTCCTTTCCAATTG	0.498000													13	32					0	0	0.016723	0	0
SERPINE1	5054	broad.mit.edu	37	7	100771685	100771685	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:100771685C>G	ENST00000223095.4	+	2	168	c.11C>G	c.(10-12)tCt>tGt	p.S4C	SERPINE1_ENST00000445463.2_Missense_Mutation_p.S4C	NM_000602.4	NP_000593.1	P05121	PAI1_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	4					angiogenesis|cellular response to chemical stimulus|cellular response to lipopolysaccharide|chronological cell aging|defense response to Gram-negative bacterium|fibrinolysis|negative regulation of apoptosis|negative regulation of cell adhesion mediated by integrin|negative regulation of fibrinolysis|negative regulation of plasminogen activation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell-matrix adhesion|negative regulation of vascular wound healing|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of interleukin-8 production|positive regulation of leukotriene production involved in inflammatory response|positive regulation of monocyte chemotaxis|positive regulation of receptor-mediated endocytosis|regulation of receptor activity	extracellular matrix|extracellular space|plasma membrane|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|prostate(3)	20	Lung NSC(181;0.136)|all_lung(186;0.182)				Atorvastatin(DB01076)|Dimethyl sulfoxide(DB01093)|Drotrecogin alfa(DB00055)|Simvastatin(DB00641)|Tenecteplase(DB00031)|Troglitazone(DB00197)|Urokinase(DB00013)	ATGCAGATGTCTCCAGCCCTC	0.622000													18	68					0	0	0.006122	0	0
HDAC9	9734	broad.mit.edu	37	7	18625115	18625115	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:18625115G>A	ENST00000406451.3	+	3	384	c.234G>A	c.(232-234)caG>caA	p.Q78Q	HDAC9_ENST00000441542.2_Silent_p.Q78Q|HDAC9_ENST00000406072.1_Silent_p.Q106Q|HDAC9_ENST00000432645.2_Silent_p.Q78Q|HDAC9_ENST00000405010.3_Silent_p.Q78Q|HDAC9_ENST00000428307.2_Silent_p.Q78Q|HDAC9_ENST00000401921.1_Silent_p.Q78Q|HDAC9_ENST00000456174.2_Silent_p.Q47Q|HDAC9_ENST00000476135.1_3'UTR|HDAC9_ENST00000417496.2_Silent_p.Q120Q|HDAC9_ENST00000524023.1_Silent_p.Q47Q	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	78					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TGACACGGCAGCACCAGGCTC	0.483000													8	35					0	0	0.006214	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212698	26212698	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:26212698G>A	ENST00000379034.1	+	2	884	c.735G>A	c.(733-735)gtG>gtA	p.V245V		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	245	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						AACATTTGGTGGTGGCCTTTG	0.507000													12	59					0	0	0.010729	0	0
BMS1P20	96610	broad.mit.edu	37	22	22658345	22658345	+	RNA	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:22658345G>T	ENST00000426066.1	+	0	112					NR_027293.1																						AATTGACCCTGACGAAGAAGA	0.313000													4	45					0.00909568	0.0098961	0.009096	1	0
TRPV3	162514	broad.mit.edu	37	17	3448539	3448539	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:3448539C>A	ENST00000301365.4	-	3	277	c.146G>T	c.(145-147)gGg>gTg	p.G49V	TRPV3_ENST00000572519.1_Missense_Mutation_p.G49V|TRPV3_ENST00000576742.1_Missense_Mutation_p.G49V			Q8NET8	TRPV3_HUMAN	transient receptor potential cation channel, subfamily V, member 3	49						integral to membrane	calcium channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(12)|ovary(5)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	35					Menthol(DB00825)	GGGTTCAAACCCTTCTATCTC	0.597000													16	42					0.00400662	0.0044664	0.028581	1	0
QSOX2	169714	broad.mit.edu	37	9	139115958	139115958	+	Splice_Site	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:139115958C>A	ENST00000358701.5	-	4	516	c.478_splice	c.e4-1	p.G160_splice		NM_181701.3	NP_859052.3	Q6ZRP7	QSOX2_HUMAN	quiescin Q6 sulfhydryl oxidase 2	160	Thioredoxin.				cell redox homeostasis	extracellular region|integral to membrane|nuclear membrane|plasma membrane	thiol oxidase activity	p.G160E(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)	22		Myeloproliferative disorder(178;0.0511)		Epithelial(140;7.78e-08)|OV - Ovarian serous cystadenocarcinoma(145;1.55e-07)		TCGGTCAGGTCCTGCCGGAAG	0.657000													14	30					6.31663e-08	9.27712e-08	0.024245	1	0
OCA2	4948	broad.mit.edu	37	15	28096612	28096612	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:28096612G>T	ENST00000354638.3	-	22	2409	c.2254C>A	c.(2254-2256)Ctc>Atc	p.L752I	OCA2_ENST00000353809.5_Missense_Mutation_p.L728I	NM_000275.2	NP_000266.2	Q04671	P_HUMAN	oculocutaneous albinism II	752					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AGGTTCAGGAGCACGGGAATC	0.572000									Oculocutaneous Albinism				4	13					2.56e-06	3.43353e-06	0.009096	1	0
NALCN	259232	broad.mit.edu	37	13	101944629	101944629	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr13:101944629C>A	ENST00000251127.6	-	8	969	c.888G>T	c.(886-888)tgG>tgT	p.W296C	NALCN_ENST00000376196.3_Missense_Mutation_p.W296C|NALCN_ENST00000470333.1_5'UTR	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	296						integral to membrane	sodium channel activity|voltage-gated ion channel activity	p.W296*(1)		NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AGTAGGAACGCCAACGGGGAA	0.458000													13	20					2.27111e-07	3.21741e-07	0.013537	1	0
BRINP1	1620	broad.mit.edu	37	9	121976385	121976385	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:121976385G>A	ENST00000265922.3	-	6	1195	c.734C>T	c.(733-735)tCg>tTg	p.S245L	DBC1_ENST00000373964.2_Missense_Mutation_p.S245L	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		245	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						GCTCAAGGCCGACTGGACAAA	0.478000													6	50					0	0	0.021553	0	0
WSCD2	9671	broad.mit.edu	37	12	108589949	108589949	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:108589949G>T	ENST00000332082.4	+	3	1158	c.340G>T	c.(340-342)Gcc>Tcc	p.A114S	WSCD2_ENST00000261400.3_Missense_Mutation_p.A114S|WSCD2_ENST00000547525.1_Missense_Mutation_p.A114S|WSCD2_ENST00000549903.1_Missense_Mutation_p.A114S			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	114						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						CTGGAGCCGAGCCCTCAAGGG	0.592000													6	44					0.0215528	0.0228285	0.021553	1	0
DCAF12L2	340578	broad.mit.edu	37	X	125299247	125299247	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:125299247G>T	ENST00000538699.1	-	2	741	c.661C>A	c.(661-663)Cgg>Agg	p.R221R	DCAF12L2_ENST00000360028.2_Silent_p.R221R	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	221										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						GGGTCCATCCGCCACAGAGCC	0.637000													12	33					6.40141e-05	7.87154e-05	0.010729	1	0
PRR12	57479	broad.mit.edu	37	19	50099610	50099610	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:50099610G>A	ENST00000418929.2	+	4	2030	c.2018G>A	c.(2017-2019)gGa>gAa	p.G673E		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	416	Pro-rich.						DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GCCTCTAAGGGACTTGGGGGG	0.672000													3	10					0	0	0.009096	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998837	27998837	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:27998837G>T	ENST00000441525.1	-	1	729	c.615C>A	c.(613-615)aaC>aaA	p.N205K		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	205										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						TGCCACGCTGGTTAAAGTGTA	0.537000													6	25					4.096e-09	6.38826e-09	0.021553	1	0
UNC79	57578	broad.mit.edu	37	14	94089109	94089109	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:94089109G>T	ENST00000553484.1	+	31	5750	c.5596G>T	c.(5596-5598)Gct>Tct	p.A1866S	UNC79_ENST00000555664.1_Missense_Mutation_p.A1844S|UNC79_ENST00000393151.2_Missense_Mutation_p.A1844S|UNC79_ENST00000256339.4_Missense_Mutation_p.A1667S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1844						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						GAGGAAGATTGCTGTCAGTGC	0.468000													10	32					1.58986e-06	2.1579e-06	0.008291	1	0
MARCO	8685	broad.mit.edu	37	2	119735461	119735461	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:119735461C>G	ENST00000541757.1	+	9	862	c.482C>G	c.(481-483)cCa>cGa	p.P161R	MARCO_ENST00000327097.4_Missense_Mutation_p.P239R			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	239	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						CTCATTGGCCCAAAAGGGGAA	0.592000													5	17					0	0	0.021553	0	0
CREB5	9586	broad.mit.edu	37	7	28848929	28848929	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:28848929G>A	ENST00000357727.2	+	9	1542	c.1152G>A	c.(1150-1152)cgG>cgA	p.R384R	CREB5_ENST00000396299.2_Silent_p.R351R|CREB5_ENST00000396298.2_Silent_p.R245R|CREB5_ENST00000396300.2_Silent_p.R377R|CREB5_ENST00000409603.1_Silent_p.R351R	NM_182898.2	NP_878901.2	Q02930	CREB5_HUMAN	cAMP responsive element binding protein 5	384					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(13)|prostate(1)|skin(3)	32						TTCTGGAACGGAACCGGGCAG	0.592000													13	49					0	0	0.016723	0	0
ABCA12	26154	broad.mit.edu	37	2	215815684	215815684	+	Silent	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:215815684A>G	ENST00000272895.7	-	45	6990	c.6771T>C	c.(6769-6771)taT>taC	p.Y2257Y	AC072062.1_ENST00000607412.1_RNA|ABCA12_ENST00000389661.4_Silent_p.Y1939Y	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2257	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		TTGTGAGACAATAAAGTTGGA	0.413000													39	103					0	0	0.021022	0	0
SLC4A10	57282	broad.mit.edu	37	2	162719434	162719434	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:162719434C>T	ENST00000375514.5	+	7	948	c.661C>T	c.(661-663)Cgc>Tgc	p.R221C	SLC4A10_ENST00000535165.1_Missense_Mutation_p.R210C|SLC4A10_ENST00000493021.1_3'UTR|SLC4A10_ENST00000421911.1_Missense_Mutation_p.R210C|SLC4A10_ENST00000272716.5_Missense_Mutation_p.R210C|SLC4A10_ENST00000446997.1_Missense_Mutation_p.R210C|SLC4A10_ENST00000415876.2_Missense_Mutation_p.R210C	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	210					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TGAAGATGTACGCCATAGGGT	0.438000													4	23					0	0	0.009096	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712430	140712430	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:140712430G>T	ENST00000517417.1	+	1	2179	c.2179G>T	c.(2179-2181)Gct>Tct	p.A727S	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.A727S	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTGCTACAGGCTTCGGGAGG	0.667000													22	75					1.96292e-10	3.18565e-10	0.010504	1	0
INADL	10207	broad.mit.edu	37	1	62626579	62626579	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:62626579G>T	ENST00000371158.2	+	43	5492		c.e43-1			NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)						intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CTTGTTTGTAGGGAGCAGCTG	0.403000													5	54					0.014758	0.0157542	0.014758	1	0
CENPI	2491	broad.mit.edu	37	X	100381698	100381698	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:100381698G>T	ENST00000372927.1	+	8	965	c.687_splice	c.e8-1	p.G230_splice	CENPI_ENST00000372926.1_Splice_Site_p.G230_splice|CENPI_ENST00000218507.5_Splice_Site_p.G230_splice|CENPI_ENST00000423383.1_Splice_Site_p.G230_splice	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I	230					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(19)|prostate(1)|skin(2)	30						TTTATTTCAGGGAATGCAGCC	0.353000													10	398					7.48243e-07	1.03838e-06	0.006214	1	0
CYTL1	54360	broad.mit.edu	37	4	5018685	5018685	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:5018685A>T	ENST00000307746.4	-	3	231	c.205T>A	c.(205-207)Tgt>Agt	p.C69S		NM_018659.2	NP_061129.1	Q9NRR1	CYTL1_HUMAN	cytokine-like 1	69					signal transduction	extracellular space|soluble fraction	receptor binding			breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		TCCAGCACACAGTAATTCTGG	0.557000													20	97					0	0	0.008871	0	0
SPEG	10290	broad.mit.edu	37	2	220315884	220315884	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:220315884G>C	ENST00000312358.7	+	5	2272	c.2140G>C	c.(2140-2142)Gct>Cct	p.A714P	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396698.1_Missense_Mutation_p.A610P	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	714					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity	p.V712_P722del(1)		breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CTACGTGTCCGCTGGAGAAGA	0.587000													12	120					0	0	0.013537	0	0
PGP	283871	broad.mit.edu	37	16	2263992	2263992	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:2263992T>A	ENST00000333503.7	-	2	732	c.703A>T	c.(703-705)Aag>Tag	p.K235*		NM_001042371.2	NP_001035830.1	A6NDG6	PGP_HUMAN	phosphoglycolate phosphatase	235					carbohydrate metabolic process		phosphoglycolate phosphatase activity			skin(1)	1						CGGCTGGGCTTCCCGATGATG	0.662000													12	83					0	0	0.024245	0	0
PXDNL	137902	broad.mit.edu	37	8	52284529	52284529	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:52284529C>A	ENST00000356297.4	-	19	3905	c.3805G>T	c.(3805-3807)Gct>Tct	p.A1269S	PXDNL_ENST00000543296.1_Missense_Mutation_p.A1269S	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1269					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AAGACATCAGCCTGCACTTGC	0.542000													5	16					0.014758	0.0157542	0.014758	1	0
LMOD2	442721	broad.mit.edu	37	7	123302771	123302771	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:123302771C>A	ENST00000458573.2	+	2	1288	c.1131C>A	c.(1129-1131)acC>acA	p.T377T	LMOD2_ENST00000456238.2_Intron	NM_207163.1	NP_997046.1	Q6P5Q4	LMOD2_HUMAN	leiomodin 2 (cardiac)	377						cytoskeleton	actin binding|tropomyosin binding										ATCTTAGGACCAAAGTCTGGC	0.468000													18	87					0.000132079	0.000158401	0.008871	1	0
EPHB1	2047	broad.mit.edu	37	3	134968224	134968224	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:134968224T>A	ENST00000398015.3	+	15	3107	c.2737T>A	c.(2737-2739)Ttt>Att	p.F913I	EPHB1_ENST00000493838.1_Missense_Mutation_p.F474I	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	913	SAM.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						CTTCACGGCCTTTACCACCGT	0.587000													14	50					0	0	0.020292	0	0
PLOD1	5351	broad.mit.edu	37	1	12024297	12024297	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:12024297G>T	ENST00000196061.4	+	12	1295	c.1268G>T	c.(1267-1269)aGt>aTt	p.S423I	PLOD1_ENST00000376369.3_Missense_Mutation_p.S470I	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	423					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	GGGGCTCTCAGTGCAGATGGC	0.632000													37	159					4.01765e-15	7.44415e-15	0.036044	1	0
BOD1L1	259282	broad.mit.edu	37	4	13606600	13606600	+	Missense_Mutation	SNP	C	C	T	rs151278291	byFrequency	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:13606600C>T	ENST00000040738.5	-	10	2059	c.1924G>A	c.(1924-1926)Gac>Aac	p.D642N		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	642	Lys-rich.						DNA binding										TTGTTTTCGTCAACTACATGC	0.398000													25	61					0	0	0.018920	0	0
OR7A10	390892	broad.mit.edu	37	19	14952304	14952304	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:14952304G>T	ENST00000248058.1	-	1	385	c.386C>A	c.(385-387)cCt>cAt	p.P129H		NM_001005190.1	NP_001005190.1	O76100	OR7AA_HUMAN	olfactory receptor, family 7, subfamily A, member 10	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|stomach(1)	19	Ovarian(108;0.203)					GTAGTGCAGAGGGTGACAGAT	0.468000													9	58					2.17888e-05	2.74377e-05	0.006214	1	0
OR11G2	390439	broad.mit.edu	37	14	20665719	20665719	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:20665719G>T	ENST00000357366.3	+	1	225	c.225G>T	c.(223-225)ctG>ctT	p.L75L		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		TTTACCTCCTGACCCTCATGG	0.562000													18	73					8.00594e-06	1.05301e-05	0.007413	1	0
UMOD	7369	broad.mit.edu	37	16	20359765	20359765	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:20359765G>T	ENST00000396134.2	-	4	1080	c.957C>A	c.(955-957)taC>taA	p.Y319*	UMOD_ENST00000570689.1_Nonsense_Mutation_p.Y286*|UMOD_ENST00000424589.1_Nonsense_Mutation_p.Y319*|UMOD_ENST00000302509.4_Nonsense_Mutation_p.Y286*|UMOD_ENST00000396138.4_Nonsense_Mutation_p.Y335*|UMOD_ENST00000396142.2_Nonsense_Mutation_p.Y286*	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	286					cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GACCTGTGCAGTACGCCAGGT	0.632000													10	36					0.000673444	0.000778813	0.008291	1	0
ZSCAN21	7589	broad.mit.edu	37	7	99654701	99654701	+	Silent	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:99654701G>C	ENST00000292450.4	+	2	236	c.72G>C	c.(70-72)ctG>ctC	p.L24L	ZSCAN21_ENST00000456748.2_Silent_p.L24L|ZSCAN21_ENST00000543588.1_Silent_p.L24L|ZSCAN21_ENST00000477297.1_3'UTR	NM_145914.2	NP_666019.1	Q9Y5A6	ZSC21_HUMAN	zinc finger and SCAN domain containing 21	24					positive regulation of transcription, DNA-dependent|viral reproduction	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|skin(1)	21	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TGGGGCCTCTGATGGTAAAAG	0.542000													8	247					0	0	0.003080	0	0
HSPA13	6782	broad.mit.edu	37	21	15746076	15746076	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr21:15746076G>A	ENST00000285667.3	-	5	1345	c.1278C>T	c.(1276-1278)ccC>ccT	p.P426P	HSPA13_ENST00000544452.1_Silent_p.P218P	NM_006948.4	NP_008879.3	P48723	HSP13_HUMAN	heat shock protein 70kDa family, member 13	426						endoplasmic reticulum|microsome	ATP binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						CAGATGTGTTGGGATCTTTTC	0.483000													14	56					0	0	0.020292	0	0
ZWILCH	55055	broad.mit.edu	37	15	66838952	66838952	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:66838952G>T	ENST00000307897.5	+	18	2091	c.1711G>T	c.(1711-1713)Ggt>Tgt	p.G571C	ZWILCH_ENST00000535141.2_Missense_Mutation_p.G457C|ZWILCH_ENST00000446801.2_Missense_Mutation_p.G457C|ZWILCH_ENST00000565627.1_Missense_Mutation_p.G457C	NM_017975.3	NP_060445.3	Q9H900	ZWILC_HUMAN	zwilch kinetochore protein	571					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(1)|lung(6)|ovary(1)	18						AACACTAAACGGTAGCCTGGA	0.373000													7	54					2.17888e-05	2.74377e-05	0.006214	1	0
KRT77	374454	broad.mit.edu	37	12	53091651	53091651	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:53091651C>A	ENST00000341809.3	-	2	601	c.573G>T	c.(571-573)gtG>gtT	p.V191V	KRT77_ENST00000537195.1_5'UTR	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	191	Coil 1A.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						TTGTTTGTAGCACCTGGTTCT	0.562000													24	125					4.26978e-12	7.27681e-12	0.018920	1	0
PKHD1	5314	broad.mit.edu	37	6	51889991	51889991	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:51889991C>A	ENST00000371117.3	-	32	4892	c.4617G>T	c.(4615-4617)caG>caT	p.Q1539H	PKHD1_ENST00000340994.4_Missense_Mutation_p.Q1539H	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	1539	IPT/TIG 10.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGTCTCTTGTCTGGCACACAA	0.443000													21	71					2.54575e-18	4.98879e-18	0.010504	1	0
KCNF1	3754	broad.mit.edu	37	2	11053046	11053046	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:11053046A>G	ENST00000295082.1	+	1	984	c.494A>G	c.(493-495)cAg>cGg	p.Q165R		NM_002236.4	NP_002227.2	Q9H3M0	KCNF1_HUMAN	potassium voltage-gated channel, subfamily F, member 1	165						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(2)|skin(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.128)		CGCCGCTGCCAGAAGTGCGTC	0.697000													8	41					0	0	0.008291	0	0
FAM86DP	692099	broad.mit.edu	37	3	75476773	75476773	+	RNA	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:75476773C>T	ENST00000459803.1	-	0	583					NR_024241.1																						AAGATGAATGCCCGGGGGCGG	0.587000													8	32					0	0	0.003080	0	0
NXPE3	91775	broad.mit.edu	37	3	101540739	101540739	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:101540739G>T	ENST00000422132.1	+	5	1818	c.1621G>T	c.(1621-1623)Gtt>Ttt	p.V541F	NXPE3_ENST00000491511.1_Missense_Mutation_p.V541F|NXPE3_ENST00000477909.1_Missense_Mutation_p.V541F|NXPE3_ENST00000273347.5_Missense_Mutation_p.V541F					neurexophilin and PC-esterase domain family, member 3																		TCCAGATGAAGTTATTGTGAA	0.498000													18	77					8.00594e-06	1.05301e-05	0.007413	1	0
ARPP21	10777	broad.mit.edu	37	3	35723305	35723305	+	Missense_Mutation	SNP	C	C	T	rs139626582		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:35723305C>T	ENST00000187397.4	+	3	518	c.62C>T	c.(61-63)aCg>aTg	p.T21M	ARPP21_ENST00000458225.1_Missense_Mutation_p.T21M|ARPP21_ENST00000474696.1_Missense_Mutation_p.T21M|ARPP21_ENST00000396481.2_Missense_Mutation_p.T21M|ARPP21_ENST00000417925.1_Missense_Mutation_p.T21M|ARPP21_ENST00000396482.2_Missense_Mutation_p.T21M|ARPP21_ENST00000436702.1_Missense_Mutation_p.T21M|ARPP21_ENST00000441454.1_Missense_Mutation_p.T21M|ARPP21_ENST00000432682.1_Missense_Mutation_p.T21M|ARPP21_ENST00000438071.1_Missense_Mutation_p.T21M|ARPP21_ENST00000337271.5_Missense_Mutation_p.T21M|ARPP21_ENST00000428373.1_Missense_Mutation_p.T21M|ARPP21_ENST00000427542.1_Missense_Mutation_p.T21M|ARPP21_ENST00000412048.1_Missense_Mutation_p.T21M|ARPP21_ENST00000444190.1_Missense_Mutation_p.T21M	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	21						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						GAGCAGGAGACGGCCACTCCA	0.468000													7	27					0	0	0.029380	0	0
COL9A1	1297	broad.mit.edu	37	6	71011744	71011744	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:71011744G>A	ENST00000357250.6	-	2	206	c.48C>T	c.(46-48)ttC>ttT	p.F16F	COL9A1_ENST00000370496.3_Silent_p.F16F	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	16					axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						AGGGTTCCAGGAAACTGCACA	0.448000													4	14					0	0	0.021553	0	0
ADAMTS16	170690	broad.mit.edu	37	5	5237092	5237092	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:5237092A>C	ENST00000274181.7	+	14	2172	c.2034A>C	c.(2032-2034)ttA>ttC	p.L678F	ADAMTS16_ENST00000513709.1_Intron	NM_139056.2	NP_620687.2	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 16	678	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(72)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	107						ATCAGGACTTATGCAAACTCT	0.333000													66	73					0	0	0.014410	0	0
CXorf57	55086	broad.mit.edu	37	X	105905439	105905439	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:105905439C>T	ENST00000372548.4	+	12	2282	c.2173C>T	c.(2173-2175)Cag>Tag	p.Q725*	CXorf57_ENST00000372544.2_Nonsense_Mutation_p.Q628*|CXorf57_ENST00000497124.1_3'UTR	NM_018015.5	NP_060485.4	Q6NSI4	CX057_HUMAN	chromosome X open reading frame 57	725										NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(5)|large_intestine(6)|lung(11)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	31						GTATAATTCTCAGCCTGCGAA	0.403000													20	74					0	0	0.008871	0	0
CLVS2	134829	broad.mit.edu	37	6	123332169	123332169	+	Silent	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:123332169T>C	ENST00000275162.4	+	3	1764	c.429T>C	c.(427-429)tcT>tcC	p.S143S	CLVS2_ENST00000368438.1_5'UTR	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	143	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						TCTTACTTTCTTTAGAAGCCA	0.393000													16	100					0	0	0.028581	0	0
POTEC	388468	broad.mit.edu	37	18	14542862	14542862	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr18:14542862C>A	ENST00000358970.5	-	1	283	c.284G>T	c.(283-285)aGg>aTg	p.R95M	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	95										NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						CATCTTGCTCCTGAGCGTCTT	0.617000													8	261					1.12685e-05	1.46233e-05	0.004482	1	0
ITGA2B	3674	broad.mit.edu	37	17	42457145	42457145	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:42457145A>T	ENST00000262407.5	-	18	1821	c.1790T>A	c.(1789-1791)gTg>gAg	p.V597E	ITGA2B_ENST00000353281.4_Missense_Mutation_p.V597E	NM_000419.3	NP_000410.2	P08514	ITA2B_HUMAN	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	597					axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			biliary_tract(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GAGGCTGAGCACAATGGGGCT	0.607000													16	87					0	0	0.028581	0	0
IZUMO2	126123	broad.mit.edu	37	19	50666245	50666245	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:50666245C>A	ENST00000293405.3	-	1	207	c.207G>T	c.(205-207)gcG>gcT	p.A69A		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	69						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						ACACGTTCAGCGCGTAGTCCC	0.682000													20	32					1.64293e-13	2.89429e-13	0.018920	1	0
NUP210	23225	broad.mit.edu	37	3	13368843	13368843	+	Missense_Mutation	SNP	C	C	A	rs61751581	byFrequency	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:13368843C>A	ENST00000254508.5	-	32	4463	c.4381G>T	c.(4381-4383)Gca>Tca	p.A1461S		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1461					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GGGTGCTCTGCGTCCCACACA	0.642000													6	28					8.12818e-05	9.85234e-05	0.029380	1	0
FAM171A1	221061	broad.mit.edu	37	10	15255469	15255469	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:15255469C>A	ENST00000378116.4	-	8	2124	c.2118G>T	c.(2116-2118)cgG>cgT	p.R706R		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	706						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						CGAACCACGCCCGGGGGTGCG	0.557000													24	66					3.08376e-08	4.6087e-08	0.018920	1	0
ZNF598	90850	broad.mit.edu	37	16	2048807	2048807	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:2048807A>T	ENST00000563630.1	-	11	2334	c.2092T>A	c.(2092-2094)Ttc>Atc	p.F698I	ZNF598_ENST00000562103.1_Missense_Mutation_p.F698I|ZNF598_ENST00000431526.1_Missense_Mutation_p.F753I			Q86UK7	ZN598_HUMAN	zinc finger protein 598	753	Pro-rich.					intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						CTCTCCCGGAAGTTCTCGGGG	0.617000													3	6					0	0	0.004672	0	0
OR51E2	81285	broad.mit.edu	37	11	4703209	4703209	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:4703209C>T	ENST00000396950.3	-	2	972	c.733G>A	c.(733-735)Ggt>Agt	p.G245S		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	245					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		AGTACCACACCAATGTGTGAC	0.498000													21	49					0	0	0.014323	0	0
TTN	7273	broad.mit.edu	37	2	179582757	179582757	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:179582757C>A	ENST00000589042.1	-	86	25200	c.24976G>T	c.(24976-24978)Gtg>Ttg	p.V8326L	TTN_ENST00000591111.1_Missense_Mutation_p.V8009L|TTN_ENST00000359218.5_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.V7082L|TTN_ENST00000342175.6_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8009	Ig-like 66.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGTGATCCACTTTGTTGATT	0.403000													21	117					2.39187e-15	4.46297e-15	0.008871	1	0
DBT	1629	broad.mit.edu	37	1	100671808	100671808	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:100671808A>T	ENST00000370132.3	-	10	1272	c.1259T>A	c.(1258-1260)aTt>aAt	p.I420N		NM_001918.3	NP_001909.3	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase E2	420					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(1)	19		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		AAGGGCCCCAATGGCTACTTC	0.333000													16	58					0	0	0.007413	0	0
TTC17	55761	broad.mit.edu	37	11	43465675	43465675	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:43465675G>C	ENST00000039989.4	+	18	2595	c.2581G>C	c.(2581-2583)Gaa>Caa	p.E861Q	TTC17_ENST00000299240.6_Missense_Mutation_p.E918Q|TTC17_ENST00000526774.1_3'UTR	NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	861							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						GAAAAAAGTAGAAACAGGTCA	0.418000													15	29					0	0	0.024245	0	0
UBR3	130507	broad.mit.edu	37	2	170863539	170863539	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:170863539G>T	ENST00000272793.5	+	28	4119	c.4069G>T	c.(4069-4071)Gaa>Taa	p.E1357*	UBR3_ENST00000418381.1_Nonsense_Mutation_p.E1357*|UBR3_ENST00000392631.1_Nonsense_Mutation_p.E178*			Q6ZT12	UBR3_HUMAN	ubiquitin protein ligase E3 component n-recognin 3 (putative)	1357					sensory perception of smell|suckling behavior|ubiquitin-dependent protein catabolic process	integral to membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(3)|stomach(1)	33						GGACAAAGGAGAATTCACGTG	0.403000													23	48					4.26978e-12	7.27681e-12	0.018920	1	0
TIMMDC1	51300	broad.mit.edu	37	3	119236073	119236073	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:119236073G>A	ENST00000494664.1	+	6	820	c.618G>A	c.(616-618)ctG>ctA	p.L206L	TIMMDC1_ENST00000493694.1_Silent_p.L72L	NM_016589.3	NP_057673.2	Q9NPL8	TIDC1_HUMAN	translocase of inner mitochondrial membrane domain containing 1	206						integral to membrane|mitochondrial inner membrane	protein transporter activity			autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	15						GAGGCCTGCTGATGGCATTTC	0.453000													5	76					0	0	0.021553	0	0
ABL2	27	broad.mit.edu	37	1	179079530	179079530	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:179079530C>A	ENST00000502732.1	-	11	1915	c.1712G>T	c.(1711-1713)cGg>cTg	p.R571L	ABL2_ENST00000367623.4_Missense_Mutation_p.R550L|ABL2_ENST00000507173.1_Missense_Mutation_p.R550L|ABL2_ENST00000511413.1_Missense_Mutation_p.R571L|ABL2_ENST00000408940.3_Missense_Mutation_p.R535L|ABL2_ENST00000344730.3_Missense_Mutation_p.R556L|ABL2_ENST00000512653.1_Missense_Mutation_p.R556L|ABL2_ENST00000504405.1_Missense_Mutation_p.R535L	NM_001168236.1|NM_001168237.1|NM_001168238.1|NM_007314.3	NP_001161708.1|NP_001161709.1|NP_001161710.1|NP_009298.1	P42684	ABL2_HUMAN	c-abl oncogene 2, non-receptor tyrosine kinase	571					axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(8)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	65					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	TATAGGTAGCCGGGGCAGGTA	0.498000			T	ETV6	AML								31	96					5.77227e-19	1.13772e-18	0.037714	1	0
FRMD3	257019	broad.mit.edu	37	9	85926821	85926821	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:85926821T>C	ENST00000304195.3	-	8	960	c.754A>G	c.(754-756)Aga>Gga	p.R252G	FRMD3_ENST00000376434.1_Missense_Mutation_p.R58G|FRMD3_ENST00000376438.1_Missense_Mutation_p.R252G	NM_001244960.1|NM_174938.5	NP_001231889.1|NP_777598.3	A2A2Y4	FRMD3_HUMAN	FERM domain containing 3	252	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane|integral to membrane	cytoskeletal protein binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	30						AAATGGATTCTCTTATTTCCC	0.378000													5	37					0	0	0.012319	0	0
LRP2	4036	broad.mit.edu	37	2	170094605	170094605	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:170094605C>G	ENST00000263816.3	-	27	4787	c.4502G>C	c.(4501-4503)aGa>aCa	p.R1501T		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	1501					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACTTACCACTCTTCTGTCCGT	0.443000													3	39					0	0	0.004672	0	0
SERBP1	26135	broad.mit.edu	37	1	67889914	67889914	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:67889914C>T	ENST00000370994.4	-	5	838	c.724G>A	c.(724-726)Gaa>Aaa	p.E242K	SERBP1_ENST00000484880.1_5'UTR|SERBP1_ENST00000361219.6_Missense_Mutation_p.E248K|SERBP1_ENST00000370995.2_Missense_Mutation_p.E263K|SERBP1_ENST00000370990.5_Missense_Mutation_p.E257K	NM_001018067.1|NM_001018068.1|NM_001018069.1|NM_015640.3	NP_001018077.1|NP_001018078.1|NP_001018079.1|NP_056455.3	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1	263					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(2)	13						GGATGATGTTCTTCACCTTCA	0.368000													19	102					0	0	0.018920	0	0
BTBD7	55727	broad.mit.edu	37	14	93712551	93712551	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:93712551C>A	ENST00000334746.5	-	10	2510	c.2203G>T	c.(2203-2205)Gta>Tta	p.V735L	BTBD7_ENST00000393170.2_Missense_Mutation_p.V309L|BTBD7_ENST00000554565.1_Missense_Mutation_p.V384L	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	735										breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		GTACTGTTTACGCGACATCTC	0.473000													35	102					1.45844e-13	2.57594e-13	0.013726	1	0
PDGFRA	5156	broad.mit.edu	37	4	55155261	55155261	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:55155261C>A	ENST00000257290.5	+	21	3191	c.2860C>A	c.(2860-2862)Ctg>Atg	p.L954M	FIP1L1_ENST00000507166.1_Missense_Mutation_p.L714M	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	954	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GGAGAATCTGCTGCCTGGACA	0.488000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			8	35					0.00307968	0.00343872	0.003080	1	0
MROH7	374977	broad.mit.edu	37	1	55158101	55158101	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:55158101G>C	ENST00000414150.2	+	16	2994	c.2716G>C	c.(2716-2718)Gtg>Ctg	p.V906L	MROH7_ENST00000395690.2_Missense_Mutation_p.V906L|MROH7_ENST00000454855.2_Missense_Mutation_p.V424L|MROH7_ENST00000409996.1_Missense_Mutation_p.V474L|MROH7_ENST00000339553.5_Missense_Mutation_p.V906L|MROH7_ENST00000545244.1_Missense_Mutation_p.V474L|MROH7_ENST00000421030.2_Missense_Mutation_p.V906L					maestro heat-like repeat family member 7																		TGGCAGCTGGGTGGTGAAAGT	0.597000													23	87					0	0	0.024334	0	0
EFCAB14	9813	broad.mit.edu	37	1	47183662	47183662	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:47183662C>A	ENST00000371933.3	-	1	1074	c.98G>T	c.(97-99)cGc>cTc	p.R33L	EFCAB14_ENST00000544071.1_Missense_Mutation_p.R33L	NM_014774.2	NP_055589.1			EF-hand calcium binding domain 14																		AGGCTCAGTGCGAAGCAGGCG	0.537000													7	34					8.12818e-05	9.85234e-05	0.029380	1	0
PCDHB10	56126	broad.mit.edu	37	5	140572143	140572143	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:140572143G>T	ENST00000239446.4	+	1	202	c.18G>T	c.(16-18)ttG>ttT	p.L6F		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		6					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAGAGAGTTGTGCTTCCCAA	0.478000													30	97					1.08312e-15	2.05159e-15	0.009535	1	0
APEX2	27301	broad.mit.edu	37	X	55033290	55033290	+	Missense_Mutation	SNP	C	C	A	rs138407648	byFrequency	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:55033290C>A	ENST00000374987.3	+	6	1045	c.979C>A	c.(979-981)Cgc>Agc	p.R327S		NM_014481.2	NP_055296.2	Q9UBZ4	APEX2_HUMAN	APEX nuclease (apurinic/apyrimidinic endonuclease) 2	327					cell cycle|DNA recombination|DNA repair	nucleus	DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|endonuclease activity|exonuclease activity|zinc ion binding			breast(1)|endometrium(8)|large_intestine(4)|lung(6)|prostate(1)|urinary_tract(1)	21						TCTGTGCACCCGCTTCCTCCC	0.572000								Other BER factors					3	34					0.004672	0.00513241	0.004672	1	0
HACE1	57531	broad.mit.edu	37	6	105192070	105192070	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:105192070C>T	ENST00000262903.4	-	22	2754	c.2478G>A	c.(2476-2478)gaG>gaA	p.E826E	HACE1_ENST00000517995.1_5'UTR|HACE1_ENST00000369125.2_Silent_p.E611E	NM_020771.3	NP_065822.2	Q8IYU2	HACE1_HUMAN	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	826	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	endoplasmic reticulum	ubiquitin-protein ligase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	44		all_cancers(87;6.89e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0216)|Colorectal(196;0.202)		BRCA - Breast invasive adenocarcinoma(108;0.122)|Epithelial(106;0.204)		GAACTCTCTCCTCTTGAGTAA	0.343000													14	76					0	0	0.028581	0	0
TSEN34	79042	broad.mit.edu	37	19	54695979	54695979	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:54695979C>T	ENST00000396383.1	+	4	811	c.500C>T	c.(499-501)tCc>tTc	p.S167F	TSEN34_ENST00000396388.2_Missense_Mutation_p.S167F|TSEN34_ENST00000429671.2_Missense_Mutation_p.S167F|TSEN34_ENST00000302937.4_Missense_Mutation_p.S167F			Q9BSV6	SEN34_HUMAN	TSEN34 tRNA splicing endonuclease subunit	167					mRNA processing|tRNA-type intron splice site recognition and cleavage	nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity			endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	10	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCCTCGTCTTCCCAAGCAGGA	0.602000													5	77					0	0	0.021553	0	0
NDC1	55706	broad.mit.edu	37	1	54252918	54252918	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:54252918T>A	ENST00000371429.3	-	16	2311	c.1713A>T	c.(1711-1713)ttA>ttT	p.L571F	NDC1_ENST00000234725.8_Missense_Mutation_p.L456F|NDC1_ENST00000540001.1_Missense_Mutation_p.S535C|NDC1_ENST00000537333.1_Missense_Mutation_p.L236F	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		ATGCTGCTACTAAGTGCGACA	0.343000													25	135					0	0	0.021523	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147027984	147027984	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:147027984T>A	ENST00000265272.5	-	5	1358	c.891A>T	c.(889-891)aaA>aaT	p.K297N	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.K255N|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.K297N	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	297						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTCTTCTAATTTTCTTATAG	0.308000													32	126					0	0	0.015359	0	0
RB1CC1	9821	broad.mit.edu	37	8	53586509	53586509	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:53586509C>G	ENST00000025008.5	-	7	1421	c.898G>C	c.(898-900)Gat>Cat	p.D300H	RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000435644.2_Missense_Mutation_p.D300H|RB1CC1_ENST00000539297.1_Missense_Mutation_p.D300H	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	300					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AAGGGCAGATCACCATCTTTA	0.388000													28	89					0	0	0.027356	0	0
WNT1	7471	broad.mit.edu	37	12	49373341	49373341	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:49373341C>A	ENST00000293549.3	+	2	231	c.195C>A	c.(193-195)agC>agA	p.S65R		NM_005430.3	NP_005421.1	P04628	WNT1_HUMAN	wingless-type MMTV integration site family, member 1	65					brain segmentation|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|central nervous system morphogenesis|cerebellum formation|dermatome development|diencephalon development|embryonic axis specification|forebrain anterior/posterior pattern formation|fourth ventricle development|hemopoietic stem cell proliferation|hepatocyte differentiation|inner ear morphogenesis|mesoderm morphogenesis|midbrain development|midbrain-hindbrain boundary maturation during brain development|negative regulation of cell-cell adhesion|negative regulation of cell-substrate adhesion|negative regulation of DNA damage checkpoint|negative regulation of fat cell differentiation|neuron fate determination|positive regulation of fibroblast proliferation|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of lamellipodium assembly|positive regulation of Notch signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to wounding|signal transduction in response to DNA damage|Spemann organizer formation|T cell differentiation in thymus|Wnt receptor signaling pathway, calcium modulating pathway	early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled-2 binding|transcription regulatory region DNA binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	11				BRCA - Breast invasive adenocarcinoma(357;0.244)		AGCTGTTGAGCCGCAAACAGC	0.602000													11	74					0.00829132	0.00907906	0.008291	1	0
F13B	2165	broad.mit.edu	37	1	197032028	197032028	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:197032028G>A	ENST00000367412.1	-	2	267	c.224C>T	c.(223-225)aCg>aTg	p.T75M		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	75	Sushi 1.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TGTTGTACACGTGGTTTGCTC	0.373000													14	182					0	0	0.024245	0	0
OR6N2	81442	broad.mit.edu	37	1	158746645	158746645	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:158746645G>T	ENST00000339258.1	-	1	780	c.781C>A	c.(781-783)Cgg>Agg	p.R261R		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					TTCTTTAGCCGCACATACATG	0.433000													18	72					8.28177e-16	1.57748e-15	0.007413	1	0
TAS2R10	50839	broad.mit.edu	37	12	10978098	10978098	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:10978098C>A	ENST00000240619.2	-	1	859	c.771G>T	c.(769-771)ctG>ctT	p.L257L		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	257					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						ACATAAGCAGCAGTTTGTTTT	0.383000													15	97					0.000219431	0.000257709	0.020292	1	0
CEP57L1	285753	broad.mit.edu	37	6	109480491	109480491	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:109480491C>T	ENST00000407272.1	+	11	1419	c.842C>T	c.(841-843)cCa>cTa	p.P281L	CEP57L1_ENST00000521522.1_Intron|CEP57L1_ENST00000520883.1_Intron|CEP57L1_ENST00000517392.1_Missense_Mutation_p.P281L|CEP57L1_ENST00000523787.1_Missense_Mutation_p.P284L|CEP57L1_ENST00000368970.2_Missense_Mutation_p.P298L|CEP57L1_ENST00000368968.2_Missense_Mutation_p.P281L|CEP57L1_ENST00000336977.4_Intron|CEP57L1_ENST00000359793.3_Missense_Mutation_p.P281L	NM_001083535.1	NP_001077004.1	Q8IYX8	CE57L_HUMAN	centrosomal protein 57kDa-like 1	281						microtubule|microtubule organizing center				endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)	11						CATCGTGACCCACATATCCTT	0.418000													22	93					0	0	0.018920	0	0
DNAJC8	22826	broad.mit.edu	37	1	28559490	28559490	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:28559490C>A	ENST00000263697.4	-	1	46	c.20G>T	c.(19-21)aGc>aTc	p.S7I	DNAJC8_ENST00000489277.1_5'UTR	NM_014280.2	NP_055095.2	O75937	DNJC8_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 8	7					nuclear mRNA splicing, via spliceosome|protein folding	nucleoplasm	heat shock protein binding|unfolded protein binding			kidney(1)|large_intestine(3)|lung(2)	6		Colorectal(325;3.46e-05)|Lung NSC(340;4.08e-05)|all_lung(284;4.29e-05)|Renal(390;0.00121)|Breast(348;0.00345)|Ovarian(437;0.0105)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		OV - Ovarian serous cystadenocarcinoma(117;2.81e-22)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00275)|BRCA - Breast invasive adenocarcinoma(304;0.0059)|STAD - Stomach adenocarcinoma(196;0.00671)|READ - Rectum adenocarcinoma(331;0.0649)		TGAAGTCCCGCTCTCTCCTGA	0.632000													5	32					0.00116845	0.00132867	0.021553	1	0
TAS2R60	338398	broad.mit.edu	37	7	143141281	143141281	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:143141281C>G	ENST00000332690.1	+	1	736	c.736C>G	c.(736-738)Ctg>Gtg	p.L246V	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	246					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					CATAAAGGCTCTGCTGGCTCT	0.478000													23	99					0	0	0.012319	0	0
SCAF4	57466	broad.mit.edu	37	21	33043759	33043759	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr21:33043759C>A	ENST00000286835.7	-	20	3779	c.3397G>T	c.(3397-3399)Gtt>Ttt	p.V1133F	SCAF4_ENST00000399804.1_Missense_Mutation_p.V1111F|SCAF4_ENST00000434667.3_Missense_Mutation_p.V1118F	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	1133						nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						TCGGGTTCAACGGATGAGGTA	0.498000													17	53					4.14922e-12	7.10697e-12	0.028581	1	0
SPTBN1	6711	broad.mit.edu	37	2	54872392	54872392	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:54872392G>T	ENST00000333896.5	+	20	4642	c.4257G>T	c.(4255-4257)cgG>cgT	p.R1419R	SPTBN1_ENST00000356805.4_Silent_p.R1432R	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1432					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			TGGAAGTGCGGAAGAAGGAGA	0.562000													15	72					2.31682e-05	2.90671e-05	0.024245	1	0
TEP1	7011	broad.mit.edu	37	14	20849471	20849471	+	Splice_Site	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:20849471C>A	ENST00000262715.5	-	32	4688		c.e32+1		TEP1_ENST00000556935.1_Splice_Site|TEP1_ENST00000545983.1_Splice_Site	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1						telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TAGGAACTAACCAGGTGGTAA	0.557000													49	147					2.73381e-35	5.9583e-35	0.014410	1	0
FAT2	2196	broad.mit.edu	37	5	150921889	150921889	+	Silent	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:150921889A>T	ENST00000261800.5	-	9	8811	c.8799T>A	c.(8797-8799)gcT>gcA	p.A2933A		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2933	Cadherin 26.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGAAATGTCAGCATCCAGGG	0.498000													41	124					0	0	0.030466	0	0
OR10G8	219869	broad.mit.edu	37	11	123900680	123900680	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:123900680G>T	ENST00000431524.1	+	1	384	c.351G>T	c.(349-351)atG>atT	p.M117I		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	117					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		ACAGGGTCATGTCCTGTGATC	0.557000													57	85					1.46156e-29	3.1352e-29	0.014410	1	0
GABRG1	2565	broad.mit.edu	37	4	46053569	46053569	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:46053569G>T	ENST00000295452.4	-	8	1170	c.1003C>A	c.(1003-1005)Ctc>Atc	p.L335I		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	335					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		GAAACAAAGAGATCCATCGCA	0.383000													19	49					2.39187e-15	4.46297e-15	0.008871	1	0
BMP2K	55589	broad.mit.edu	37	4	79832722	79832722	+	Silent	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:79832722T>A	ENST00000335016.5	+	16	3187	c.3021T>A	c.(3019-3021)acT>acA	p.T1007T	PAQR3_ENST00000295462.3_Intron	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	1007						nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						CAAAGAAGACTTTGAAGCCTA	0.493000													27	51					0	0	0.024334	0	0
PABPC5	140886	broad.mit.edu	37	X	90691151	90691151	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:90691151C>A	ENST00000312600.3	+	2	789	c.575C>A	c.(574-576)aCc>aAc	p.T192N	PABPC5_ENST00000373105.1_Missense_Mutation_p.T28N	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	192						cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						GAGGTCAGAACCAGGGATAGA	0.463000													15	48					6.31663e-08	9.27712e-08	0.024245	1	0
DNAJC21	134218	broad.mit.edu	37	5	34937456	34937456	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:34937456G>T	ENST00000382021.2	+	5	691	c.464G>T	c.(463-465)tGg>tTg	p.W155L	DNAJC21_ENST00000342382.4_Missense_Mutation_p.W155L|DNAJC21_ENST00000303525.7_Missense_Mutation_p.W155L	NM_194283.3	NP_919259.3	Q5F1R6	DJC21_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 21	155					protein folding	ribosome	heat shock protein binding|nucleic acid binding|unfolded protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(31;7.08e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)			TACGCTTATTGGCAGAGTTTC	0.373000													11	107					2.80697e-09	4.40818e-09	0.010729	1	0
CTSH	1512	broad.mit.edu	37	15	79229742	79229742	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:79229742C>T	ENST00000220166.5	-	3	256	c.147G>A	c.(145-147)gaG>gaA	p.E49E		NM_004390.3	NP_004381.2	P09668	CATH_HUMAN	cathepsin H	49					protein destabilization|proteolysis	lysosome	cysteine-type endopeptidase activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)	10						GGTGGTACTCCTCCGTACTGT	0.493000													13	39					0	0	0.020292	0	0
AKAP6	9472	broad.mit.edu	37	14	33014693	33014693	+	Silent	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:33014693T>A	ENST00000280979.4	+	4	1004	c.834T>A	c.(832-834)gcT>gcA	p.A278A	AKAP6_ENST00000557272.1_Silent_p.A278A|AKAP6_ENST00000557354.1_Silent_p.A278A	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	278					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TTACGGTAGCTGCTGACTCTA	0.453000													28	84					0	0	0.009535	0	0
CYP2W1	54905	broad.mit.edu	37	7	1027059	1027059	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:1027059C>A	ENST00000340150.6	+	7	889	c.867C>A	c.(865-867)ccC>ccA	p.P289P	CYP2W1_ENST00000308919.7_Silent_p.P345P			Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W, polypeptide 1	345					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		AGGCTCTGCCCTACACAAGCG	0.721000													4	9					0.000602214	0.000698815	0.014758	1	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74834759	74834759	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:74834759C>A	ENST00000370895.1	+	16	1713	c.1678C>A	c.(1678-1680)Cag>Aag	p.Q560K	TNNI3K_ENST00000326637.3_Missense_Mutation_p.Q459K|TNNI3K_ENST00000370891.2_Missense_Mutation_p.Q560K|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.Q560K|RP11-439H8.4_ENST00000415549.2_RNA|FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.Q560K			Q59H18	TNI3K_HUMAN		459	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										TTTCCATCTTCAGCTCTCAGA	0.338000													15	33					1.3612e-06	1.86994e-06	0.024245	1	0
GCM2	9247	broad.mit.edu	37	6	10874470	10874470	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:10874470G>T	ENST00000379491.4	-	5	1426	c.1279C>A	c.(1279-1281)Cca>Aca	p.P427T	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	427					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding	p.P427A(2)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				CAGGGTTCTGGATAGACAGAC	0.552000													9	39					2.17888e-05	2.74377e-05	0.006214	1	0
GAD2	2572	broad.mit.edu	37	10	26581395	26581395	+	Splice_Site	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:26581395G>A	ENST00000376261.3	+	14	1891	c.1386_splice	c.e14-1	p.G463_splice	GAD2_ENST00000259271.3_Splice_Site_p.G463_splice	NM_001134366.1	NP_001127838.1	Q05329	DCE2_HUMAN	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	463					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	CTTACCTAGGGGACTACCGGG	0.463000													7	74					0	0	0.004482	0	0
GPCPD1	56261	broad.mit.edu	37	20	5566906	5566906	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:5566906C>A	ENST00000379019.4	-	5	453	c.241G>T	c.(241-243)Ggt>Tgt	p.G81C		NM_019593.3	NP_062539.1	Q9NPB8	GPCP1_HUMAN	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	81	CBM20.				glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)	16						TGACATGGACCACCGATAGTC	0.373000													28	123					1.50538e-07	2.15962e-07	0.030593	1	0
PER3	8863	broad.mit.edu	37	1	7887411	7887411	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:7887411C>T	ENST00000377532.3	+	17	2646	c.2422C>T	c.(2422-2424)Cca>Tca	p.P808S	PER3_ENST00000361923.2_Missense_Mutation_p.P800S			P56645	PER3_HUMAN	period circadian clock 3	800	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TTACCTCGTCCCAGCTTTTCC	0.697000													19	73					0	0	0.007413	0	0
CCDC135	84229	broad.mit.edu	37	16	57760106	57760106	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:57760106G>T	ENST00000360716.3	+	14	2106	c.1885G>T	c.(1885-1887)Gcc>Tcc	p.A629S	CCDC135_ENST00000336825.8_Missense_Mutation_p.A564S|CCDC135_ENST00000394337.4_Missense_Mutation_p.A629S			Q8IY82	CC135_HUMAN	coiled-coil domain containing 135	629						cytoplasm				breast(1)|central_nervous_system(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	30						CCACATCACGGCCTCCAAGCG	0.652000													14	39					4.3838e-07	6.15906e-07	0.016723	1	0
SNHG14	104472715	broad.mit.edu	37	15	25463705	25463705	+	RNA	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:25463705G>T	ENST00000424208.1	+	0	2988				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						GCACTGAGCTGTGATGAGTAC	0.582000													17	138					3.45872e-05	4.31546e-05	0.028581	1	0
SRRM2	23524	broad.mit.edu	37	16	2813501	2813501	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:2813501G>T	ENST00000301740.8	+	11	3521	c.2972G>T	c.(2971-2973)gGg>gTg	p.G991V		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	991	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						AGTCACTCAGGGTCTATTTCA	0.473000													31	156					9.45814e-24	1.93721e-23	0.021022	1	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112997080	112997080	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:112997080G>T	ENST00000271277.6	+	5	565	c.340G>T	c.(340-342)Gac>Tac	p.D114Y		NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	114						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GGTGATCCTAGACCTTGAGGA	0.398000													7	54					0.00307968	0.00343872	0.003080	1	0
H3F3C	440093	broad.mit.edu	37	12	31944778	31944778	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:31944778T>A	ENST00000340398.3	-	1	397	c.323A>T	c.(322-324)aAc>aTc	p.N108I		NM_001013699.2	NP_001013721.2	Q6NXT2	H3C_HUMAN	H3 histone, family 3C	108					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	18						GGCACACAGGTTAGTATCTTC	0.552000										HNSCC(67;0.2)			28	85					0	0	0.030593	0	0
SYAP1	94056	broad.mit.edu	37	X	16761894	16761894	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:16761894C>T	ENST00000380155.3	+	5	599	c.506C>T	c.(505-507)cCc>cTc	p.P169L		NM_032796.3	NP_116185.2	Q96A49	SYAP1_HUMAN	synapse associated protein 1	169	BSD.									endometrium(3)|lung(4)|pancreas(1)|prostate(1)|skin(1)	10	Hepatocellular(33;0.0997)					CAGATGTACCCCGTGGCCCTG	0.468000													6	226					0	0	0.021553	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118202628	118202628	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:118202628C>A	ENST00000369230.3	+	3	412	c.266C>A	c.(265-267)aCc>aAc	p.T89N		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	89					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		GACAAGATCACCCGTATCAAC	0.388000													5	48					0.014758	0.0157542	0.014758	1	0
RASGRF1	5923	broad.mit.edu	37	15	79294032	79294032	+	Silent	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:79294032G>C	ENST00000419573.3	-	17	2869	c.2595C>G	c.(2593-2595)ccC>ccG	p.P865P	RASGRF1_ENST00000558480.2_Silent_p.P849P|RASGRF1_ENST00000560334.1_5'UTR|RASGRF1_ENST00000394745.3_Silent_p.P81P	NM_002891.4	NP_002882.3	Q13972	RGRF1_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 1	867					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(18)|lung(23)|ovary(2)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						TGACTGATTTGGGTGTTGTTG	0.408000													23	121					0	0	0.021523	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162280	33162280	+	RNA	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:33162280G>C	ENST00000510327.1	-	0	346																											AGCCAGCGCCGAGCGATGGGC	0.488000													40	33					0	0	0.013114	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839708	128839708	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:128839708C>A	ENST00000310343.9	-	22	5357	c.5358G>T	c.(5356-5358)ggG>ggT	p.G1786G	ARHGAP32_ENST00000392657.3_Silent_p.G1437G|ARHGAP32_ENST00000524655.1_3'UTR|ARHGAP32_ENST00000527272.1_Silent_p.G1437G	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1786	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						TGACATAGATCCCACCCAAGT	0.547000													39	63					7.53189e-24	1.54734e-23	0.030466	1	0
NEDD4	4734	broad.mit.edu	37	15	56208095	56208095	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:56208095C>A	ENST00000508342.1	-	1	1234	c.935G>T	c.(934-936)gGc>gTc	p.G312V	NEDD4_ENST00000338963.2_Missense_Mutation_p.G312V|NEDD4_ENST00000506154.1_Missense_Mutation_p.G312V|NEDD4_ENST00000435532.3_Intron			P46934	NEDD4_HUMAN	neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase	312					development involved in symbiotic interaction|glucocorticoid receptor signaling pathway|negative regulation of sodium ion transport|negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage|negative regulation of vascular endothelial growth factor receptor signaling pathway|neuron projection development|positive regulation of nucleocytoplasmic transport|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein catabolic process|progesterone receptor signaling pathway|protein K63-linked ubiquitination|protein targeting to lysosome|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|receptor catabolic process|receptor internalization|regulation of dendrite morphogenesis|response to calcium ion|transmission of virus	apicolateral plasma membrane|cell cortex|chromatin|cytosol|perinuclear region of cytoplasm|ubiquitin ligase complex	beta-2 adrenergic receptor binding|phosphoserine binding|phosphothreonine binding|proline-rich region binding|protein domain specific binding|RNA polymerase binding|sodium channel inhibitor activity|ubiquitin binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(15)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	43				all cancers(107;0.0299)|GBM - Glioblastoma multiforme(80;0.113)		AGCACTAGTGCCATCCTCATT	0.413000													11	97					6.40141e-05	7.87154e-05	0.010729	1	0
SORCS3	22986	broad.mit.edu	37	10	106675691	106675691	+	Splice_Site	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:106675691G>A	ENST00000369701.3	+	3	1022		c.e3+1			NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3							integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CAAAAGGAAGGTAAGAGACTG	0.448000													8	50					0	0	0.004482	0	0
NCAM2	4685	broad.mit.edu	37	21	22710708	22710708	+	Splice_Site	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr21:22710708G>A	ENST00000400546.1	+	8	1147		c.e8-1		NCAM2_ENST00000535285.1_Splice_Site|NCAM2_ENST00000284894.7_Splice_Site	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2						neuron cell-cell adhesion	integral to membrane|plasma membrane				breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		ATTCTTTACAGTACAGCCTCA	0.358000													9	37					0	0	0.010729	0	0
WNK3	65267	broad.mit.edu	37	X	54275171	54275171	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:54275171G>A	ENST00000354646.2	-	17	4048	c.3610C>T	c.(3610-3612)Ctg>Ttg	p.L1204L	WNK3_ENST00000375159.2_Silent_p.L1204L|WNK3_ENST00000375169.3_Silent_p.L1204L	NM_020922.4	NP_065973.2	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3	1204					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			autonomic_ganglia(1)|biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(24)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80						ATCACATTCAGGTCCCTTTTG	0.393000													8	36					0	0	0.003080	0	0
C9orf43	257169	broad.mit.edu	37	9	116186556	116186556	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:116186556C>T	ENST00000288462.4	+	8	1213	c.767C>T	c.(766-768)tCt>tTt	p.S256F	C9orf43_ENST00000374165.1_Missense_Mutation_p.S256F	NM_152786.1	NP_689999.1	Q8TAL5	CI043_HUMAN	chromosome 9 open reading frame 43	256										breast(2)|large_intestine(6)|lung(2)|ovary(1)|pancreas(1)|prostate(3)	15						AGTGTGATTTCTTCTAAGATG	0.433000													21	170					0	0	0.014323	0	0
KIAA0947	23379	broad.mit.edu	37	5	5489358	5489358	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:5489358G>A	ENST00000296564.7	+	19	6938	c.6716G>A	c.(6715-6717)cGg>cAg	p.R2239Q		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	2239										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						GAAGCTTGGCGGAGAGAGGCC	0.532000													3	47					0	0	0.004672	0	0
RAD54L2	23132	broad.mit.edu	37	3	51690031	51690031	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:51690031G>T	ENST00000409535.1	+	19	3196	c.3071G>T	c.(3070-3072)cGt>cTt	p.R1024L	RAD54L2_ENST00000296477.3_Missense_Mutation_p.R718L	NM_015106.2	NP_055921.2	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2 (S. cerevisiae)	1024						nucleus	ATP binding|DNA binding|helicase activity			NS(2)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|liver(2)|lung(9)|ovary(4)|skin(2)	31				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		GCCAGTGTTCGTCCTGTGCAG	0.507000													24	123					5.45024e-15	1.00711e-14	0.018920	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125175026	125175026	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:125175026G>A	ENST00000431078.1	+	4	752	c.388G>A	c.(388-390)Gca>Aca	p.A130T		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	130	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		GCAGACCTTTGCAGGAAACAT	0.488000													7	24					0	0	0.003080	0	0
SORCS1	114815	broad.mit.edu	37	10	108412220	108412220	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:108412220C>T	ENST00000263054.6	-	18	2402	c.2395G>A	c.(2395-2397)Ggg>Agg	p.G799R	SORCS1_ENST00000369698.1_Missense_Mutation_p.G334R|SORCS1_ENST00000344440.6_Missense_Mutation_p.G799R	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	799						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ATCCGCAGCCCCCGCGGGGCT	0.522000													17	67					0	0	0.033300	0	0
POTEH	23784	broad.mit.edu	37	22	16267078	16267078	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:16267078C>T	ENST00000343518.6	-	9	1422	c.1371G>A	c.(1369-1371)aaG>aaA	p.K457K		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	457										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TTCCGTGCTTCTTCATTTCTT	0.358000													11	383					0	0	0.016723	0	0
PSME4	23198	broad.mit.edu	37	2	54133777	54133777	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:54133777C>T	ENST00000404125.1	-	26	2956	c.2901G>A	c.(2899-2901)atG>atA	p.M967I	PSME4_ENST00000421748.2_Missense_Mutation_p.M111I	NM_014614.2	NP_055429.2	Q14997	PSME4_HUMAN	proteasome (prosome, macropain) activator subunit 4	967					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell differentiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|multicellular organismal development|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|spermatogenesis|viral reproduction	nuclear speck|proteasome complex	binding			breast(5)|endometrium(8)|kidney(1)|large_intestine(11)|lung(26)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(2)	60			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GATCTCTGATCATATCTTGAT	0.353000													20	88					0	0	0.012319	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187692860	187692860	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:187692860T>C	ENST00000295131.2	-	9	1792	c.1753A>G	c.(1753-1755)Aca>Gca	p.T585A		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	585					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			AGTTTAGCTGTGCTCCAATTG	0.373000													6	61					0	0	0.021553	0	0
KRT37	8688	broad.mit.edu	37	17	39577234	39577234	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:39577234G>T	ENST00000225550.3	-	7	1245	c.1246C>A	c.(1246-1248)Ccc>Acc	p.P416T	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	416	Tail.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				GGATTGCAGGGGAGTCTGCAG	0.552000													15	31					0.000219431	0.000257709	0.020292	1	0
CYP4F2	8529	broad.mit.edu	37	19	15989681	15989681	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:15989681C>T	ENST00000221700.5	-	13	1558	c.1463G>A	c.(1462-1464)cGc>cAc	p.R488H	CYP4F2_ENST00000592328.1_Missense_Mutation_p.R488H	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	488					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						GACGCGGAAGCGCAGCAGCGT	0.677000													6	50					0	0	0.003080	0	0
DMBX1	127343	broad.mit.edu	37	1	46977793	46977793	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:46977793C>A	ENST00000371956.4	+	4	791	c.776C>A	c.(775-777)tCc>tAc	p.S259Y	DMBX1_ENST00000360032.3_Missense_Mutation_p.S254Y	NM_147192.2	NP_671725.1	Q8NFW5	DMBX1_HUMAN	diencephalon/mesencephalon homeobox 1	259					brain development|developmental growth|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Acute lymphoblastic leukemia(166;0.155)					TATTCCTCGTCCCCGCTGAGC	0.637000													33	124					2.09667e-21	4.23066e-21	0.017118	1	0
HOXC4	3221	broad.mit.edu	37	12	54447898	54447898	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:54447898G>T	ENST00000430889.2	+	1	238	c.192G>T	c.(190-192)gaG>gaT	p.E64D	HOXC4_ENST00000303406.4_Missense_Mutation_p.E64D	NM_153633.2	NP_705897.1	P09017	HXC4_HUMAN	homeobox C4	64						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	13						GCTACCCTGAGCGCCAGTATA	0.652000													27	116					2.14196e-07	3.04713e-07	0.034045	1	0
LAMB1	3912	broad.mit.edu	37	7	107626637	107626637	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:107626637G>C	ENST00000393561.1	-	4	851	c.667C>G	c.(667-669)Ccc>Gcc	p.P223A	LAMB1_ENST00000393560.1_Missense_Mutation_p.P199A|LAMB1_ENST00000222399.6_Missense_Mutation_p.P199A			P07942	LAMB1_HUMAN	laminin, beta 1	199	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCAGTTGAGGGTTCAATGTCA	0.393000													14	65					0	0	0.024245	0	0
USH2A	7399	broad.mit.edu	37	1	216465670	216465670	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:216465670G>T	ENST00000366943.2	-	10	2073	c.1687C>A	c.(1687-1689)Caa>Aaa	p.Q563K	USH2A_ENST00000366942.3_Missense_Mutation_p.Q563K|USH2A_ENST00000307340.3_Missense_Mutation_p.Q563K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	563	Laminin EGF-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGATCACCTTGGCGGAAAGGC	0.368000										HNSCC(13;0.011)			16	56					8.60227e-14	1.5516e-13	0.028581	1	0
NTNG1	22854	broad.mit.edu	37	1	107866972	107866972	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:107866972G>T	ENST00000370067.1	+	3	942	c.315G>T	c.(313-315)ctG>ctT	p.L105L	NTNG1_ENST00000370074.4_Silent_p.L105L|NTNG1_ENST00000370073.2_Silent_p.L105L|NTNG1_ENST00000370070.2_Silent_p.L105L|NTNG1_ENST00000370072.3_Silent_p.L105L|NTNG1_ENST00000370061.3_Silent_p.L105L|NTNG1_ENST00000542803.1_Silent_p.L105L|NTNG1_ENST00000370071.2_Silent_p.L105L|NTNG1_ENST00000370068.1_Silent_p.L105L|NTNG1_ENST00000370065.1_Silent_p.L105L|NTNG1_ENST00000370066.1_Silent_p.L105L|NTNG1_ENST00000477948.1_3'UTR			Q9Y2I2	NTNG1_HUMAN	netrin G1	105	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CCCCTGAGCTGATGTTTGATT	0.488000													50	194					4.01344e-20	8.02687e-20	0.014410	1	0
UBE4B	10277	broad.mit.edu	37	1	10228257	10228257	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:10228257G>T	ENST00000377157.3	+	23	3588	c.2527G>T	c.(2527-2529)Gcc>Tcc	p.A843S	UBE4B_ENST00000253251.8_Missense_Mutation_p.A959S|UBE4B_ENST00000343090.6_Missense_Mutation_p.A1088S	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	1088					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		CTCTTACCTCGCCCTGGCCAC	0.582000													6	37					5.9392e-07	8.30999e-07	0.021553	1	0
VARS	7407	broad.mit.edu	37	6	31750199	31750199	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:31750199C>A	ENST00000375663.3	-	17	2453	c.2013G>T	c.(2011-2013)gaG>gaT	p.E671D	VARS_ENST00000444930.2_3'UTR	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	671					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GCAGCAGAGGCTCTACCACGT	0.682000													5	14					0.014758	0.0157542	0.014758	1	0
ZNF728	388523	broad.mit.edu	37	19	23159271	23159271	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:23159271C>A	ENST00000594710.1	-	4	1013	c.868G>T	c.(868-870)Ggc>Tgc	p.G290C		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		AAGGCTTTGCCACATTCTTCA	0.438000													11	55					1.33987e-11	2.24966e-11	0.008291	1	0
MROH2B	133558	broad.mit.edu	37	5	41054884	41054884	+	Silent	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:41054884A>T	ENST00000399564.4	-	11	1542	c.1092T>A	c.(1090-1092)ggT>ggA	p.G364G	MROH2B_ENST00000506092.2_Intron	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		TACTGAGATCACCCATGACGA	0.363000													23	150					0	0	0.024334	0	0
NCKAP5	344148	broad.mit.edu	37	2	133489455	133489455	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:133489455G>T	ENST00000409261.1	-	17	5671	c.5298C>A	c.(5296-5298)gcC>gcA	p.A1766A	NCKAP5_ENST00000317721.6_Silent_p.A1766A|NCKAP5_ENST00000409213.1_Silent_p.A447A|NCKAP5_ENST00000405974.3_Silent_p.A447A	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1766							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CAAGGGTTTGGGCTCTCATGG	0.592000													8	81					0.000157383	0.000186772	0.003080	1	0
NAGPA	51172	broad.mit.edu	37	16	5078957	5078957	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:5078957C>A	ENST00000312251.3	-	5	863	c.844G>T	c.(844-846)Gcc>Tcc	p.A282S	NAGPA_ENST00000381955.3_Missense_Mutation_p.A282S|RP11-165E7.1_ENST00000588778.1_RNA	NM_016256.3	NP_057340.2	Q9UK23	NAGPA_HUMAN	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase	282					carbohydrate metabolic process|lysosome organization|protein modification process|protein targeting to lysosome	Golgi cisterna membrane|integral to membrane	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity			endometrium(4)|large_intestine(4)|lung(3)|urinary_tract(1)	12					N-Acetyl-D-glucosamine(DB00141)	AGGTTGATGGCGTTGACCACG	0.597000													23	122					1.10923e-09	1.75822e-09	0.016522	1	0
EMR2	30817	broad.mit.edu	37	19	14877889	14877889	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:14877889A>G	ENST00000315576.3	-	6	839	c.388T>C	c.(388-390)Tgt>Cgt	p.C130R	EMR2_ENST00000596991.2_Missense_Mutation_p.C130R|EMR2_ENST00000594076.1_Intron|EMR2_ENST00000353005.1_Intron|EMR2_ENST00000346057.1_Missense_Mutation_p.C130R|EMR2_ENST00000594294.1_Missense_Mutation_p.C130R|EMR2_ENST00000601345.1_Missense_Mutation_p.C130R|EMR2_ENST00000392967.2_Missense_Mutation_p.C130R|EMR2_ENST00000595839.1_Intron|EMR2_ENST00000392965.3_Missense_Mutation_p.C130R|EMR2_ENST00000353876.1_Intron|EMR2_ENST00000392964.3_5'UTR	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	130	EGF-like 3; calcium-binding.				cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						TAGCTTTTACAGAGCCTTGGG	0.592000													7	12					0	0	0.029380	0	0
NLRP14	338323	broad.mit.edu	37	11	7070936	7070936	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:7070936G>A	ENST00000299481.4	+	6	2504	c.2158G>A	c.(2158-2160)Gat>Aat	p.D720N		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	720					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TGGTTGTCAGGATATCTCTAC	0.378000													38	85					0	0	0.021022	0	0
CMYA5	202333	broad.mit.edu	37	5	79030276	79030276	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:79030276G>T	ENST00000446378.2	+	2	5719	c.5688G>T	c.(5686-5688)ttG>ttT	p.L1896F		NM_153610.3	NP_705838.3	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1896						perinuclear region of cytoplasm				NS(2)|breast(4)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(37)|lung(34)|ovary(6)|pancreas(2)|prostate(5)|skin(5)|stomach(11)|upper_aerodigestive_tract(3)|urinary_tract(1)	128		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		ACTGGATGTTGGGAAAGCCAG	0.433000													5	23					0.0215528	0.0228285	0.021553	1	0
NLRP5	126206	broad.mit.edu	37	19	56565158	56565158	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:56565158G>C	ENST00000390649.3	+	13	3283	c.3283G>C	c.(3283-3285)Gtt>Ctt	p.V1095L		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1095						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		AAAGAACAGTGTTCTGGCGAG	0.617000													13	39					0	0	0.028581	0	0
DOCK3	1795	broad.mit.edu	37	3	51264742	51264742	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:51264742C>T	ENST00000266037.9	+	16	1429	c.1406C>T	c.(1405-1407)cCa>cTa	p.P469L		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	469	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCAGGAGAGCCAAATAGGAGT	0.468000													21	135					0	0	0.014323	0	0
AMER3	205147	broad.mit.edu	37	2	131520863	131520863	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:131520863C>A	ENST00000423981.1	+	2	1328	c.1218C>A	c.(1216-1218)ggC>ggA	p.G406G	AMER3_ENST00000321420.4_Silent_p.G406G	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		AGAGCCCAGGCACTCCTGCCG	0.622000													7	49					0.00198382	0.00224459	0.029380	1	0
PCDH11X	27328	broad.mit.edu	37	X	91873442	91873442	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:91873442C>A	ENST00000373094.1	+	7	4392	c.3547C>A	c.(3547-3549)Cag>Aag	p.Q1183K	PCDH11X_ENST00000373088.1_Missense_Mutation_p.Q1146K|PCDH11X_ENST00000298274.8_Missense_Mutation_p.Q1146K|PCDH11X_ENST00000361655.2_Missense_Mutation_p.Q1165K|PCDH11X_ENST00000373097.1_Missense_Mutation_p.Q1173K|PCDH11X_ENST00000406881.1_Missense_Mutation_p.Q1175K|PCDH11X_ENST00000504220.1_3'UTR	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	1183					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GGCCTCTACTCAGCACCACAG	0.587000													26	73					3.01185e-09	4.70818e-09	0.021523	1	0
KCNJ5	3762	broad.mit.edu	37	11	128781592	128781592	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:128781592T>G	ENST00000529694.1	+	2	800	c.424T>G	c.(424-426)Ttc>Gtc	p.F142V	KCNJ5_ENST00000338350.4_Missense_Mutation_p.F142V|KCNJ5_ENST00000533599.1_Missense_Mutation_p.F142V	NM_000890.3	NP_000881.3	P48544	IRK5_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 5	142					synaptic transmission	voltage-gated potassium channel complex	G-protein activated inward rectifier potassium channel activity|protein binding			NS(1)|breast(1)|endometrium(4)|large_intestine(4)|liver(2)|lung(9)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_hematologic(175;0.0641)	Lung NSC(97;0.00038)|all_lung(97;0.000817)|Breast(109;0.00123)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0059)|LUSC - Lung squamous cell carcinoma(976;0.021)|Lung(977;0.0215)	Glibenclamide(DB01016)	CGCTTTCCTGTTCTCCATTGA	0.522000													50	85					0	0	0.014410	0	0
OSBP2	23762	broad.mit.edu	37	22	31091455	31091455	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:31091455G>T	ENST00000332585.6	+	1	663	c.559G>T	c.(559-561)Ggc>Tgc	p.G187C	OSBP2_ENST00000403222.3_Intron|OSBP2_ENST00000382310.3_Missense_Mutation_p.G187C|OSBP2_ENST00000407373.1_Intron|OSBP2_ENST00000446658.2_Missense_Mutation_p.G187C	NM_030758.3	NP_110385.1	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2	187	PH.				lipid transport	membrane	lipid binding			breast(3)|central_nervous_system(1)|endometrium(2)|kidney(2)|lung(6)|ovary(1)|skin(3)|urinary_tract(1)	19						CAGCTTCGAGGGCTGGCTTCT	0.597000													13	63					3.27435e-08	4.86148e-08	0.020292	1	0
USH2A	7399	broad.mit.edu	37	1	215972262	215972262	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:215972262G>T	ENST00000366943.2	-	50	10331	c.9945C>A	c.(9943-9945)taC>taA	p.Y3315*	USH2A_ENST00000307340.3_Nonsense_Mutation_p.Y3315*			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3315					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GAAGGCGATTGTACACCACTC	0.483000										HNSCC(13;0.011)			15	67					7.93312e-07	1.09422e-06	0.020292	1	0
CR2	1380	broad.mit.edu	37	1	207647210	207647210	+	Silent	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:207647210T>C	ENST00000367057.3	+	12	2409	c.2220T>C	c.(2218-2220)gtT>gtC	p.V740V	CR2_ENST00000367059.3_Silent_p.V681V|CR2_ENST00000367058.3_Silent_p.V681V|CR2_ENST00000458541.2_Silent_p.V654V	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	812	Sushi 12.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGGAGCTAGTTAATACGTCCT	0.428000													19	65					0	0	0.007413	0	0
MYH13	8735	broad.mit.edu	37	17	10222310	10222310	+	Missense_Mutation	SNP	G	G	T	rs116855901	by1000genomes	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:10222310G>T	ENST00000418404.3	-	26	3698	c.3535C>A	c.(3535-3537)Cgc>Agc	p.R1179S	MYH13_ENST00000252172.4_Missense_Mutation_p.R1179S|MYH13_ENST00000570743.1_Missense_Mutation_p.R1179S			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1179					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						AGGTCCCTGCGCATTTTCTGG	0.582000													45	122					8.01111e-26	1.68655e-25	0.010771	1	0
SRPK3	26576	broad.mit.edu	37	X	153049525	153049525	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:153049525C>A	ENST00000489426.1	+	16	3571	c.1205C>A	c.(1204-1206)tCc>tAc	p.S402Y	SRPK3_ENST00000370108.3_Intron|SRPK3_ENST00000393786.3_Intron|SRPK3_ENST00000370101.3_Missense_Mutation_p.S335Y|SRPK3_ENST00000370104.1_Missense_Mutation_p.S334Y|SRPK3_ENST00000370100.1_Intron			Q9UPE1	SRPK3_HUMAN	SRSF protein kinase 3	335	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(2)|lung(4)|ovary(2)|pancreas(2)|urinary_tract(1)	13	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCTCTTCCTCCCCCGCCCCA	0.697000													11	27					0.000673444	0.000778813	0.008291	1	0
SULT1C2	6819	broad.mit.edu	37	2	108910141	108910141	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:108910141C>A	ENST00000326853.5	+	2	471	c.18C>A	c.(16-18)gaC>gaA	p.D6E	SULT1C2_ENST00000409880.1_Missense_Mutation_p.D6E|SULT1C2_ENST00000251481.6_Missense_Mutation_p.D6E|SULT1C2_ENST00000437390.2_Missense_Mutation_p.D6E	NM_176825.2	NP_789795.1	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 2	6					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20						TGACCTCAGACCTGGGGAAAC	0.478000													14	54					2.32078e-09	3.65309e-09	0.024245	1	0
LILRB3	11025	broad.mit.edu	37	19	54724968	54724968	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:54724968G>C	ENST00000391750.1	-	6	1078	c.942C>G	c.(940-942)aaC>aaG	p.N314K	LILRB3_ENST00000245620.9_Missense_Mutation_p.N314K|LILRA6_ENST00000270464.5_Missense_Mutation_p.N314K|LILRB3_ENST00000346401.6_Missense_Mutation_p.N314K|LILRA6_ENST00000440558.2_Intron|LILRB3_ENST00000407860.2_Missense_Mutation_p.N314K|LILRB3_ENST00000424807.1_Missense_Mutation_p.N314K|LILRA6_ENST00000419410.2_Intron|LILRA6_ENST00000391735.3_Intron			O75022	LIRB3_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	314	Ig-like C2-type 3.				cell surface receptor linked signaling pathway|defense response	integral to plasma membrane	transmembrane receptor activity			endometrium(3)|kidney(13)|large_intestine(1)|lung(6)|ovary(2)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	34	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCATCAGGATGTTCAGGGGGT	0.682000													13	12					0	0	0.007413	0	0
AMER3	205147	broad.mit.edu	37	2	131521085	131521085	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:131521085C>A	ENST00000423981.1	+	2	1550	c.1440C>A	c.(1438-1440)agC>agA	p.S480R	AMER3_ENST00000321420.4_Missense_Mutation_p.S480R	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		ACCTGCTCAGCCAGGGCTTCC	0.652000													3	28					0.00909568	0.0098961	0.009096	1	0
PLCXD3	345557	broad.mit.edu	37	5	41313735	41313735	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:41313735C>A	ENST00000377801.3	-	3	1024	c.950G>T	c.(949-951)gGa>gTa	p.G317V	PLCXD3_ENST00000328457.3_Missense_Mutation_p.G317V			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	317					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						GTTGGCTTCTCCTTCATCAAA	0.403000													24	119					1.42536e-11	2.3873e-11	0.024334	1	0
CSMD1	64478	broad.mit.edu	37	8	3166007	3166007	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:3166007C>A	ENST00000602557.1	-	25	4208	c.3653G>T	c.(3652-3654)tGt>tTt	p.C1218F	CSMD1_ENST00000400186.3_Missense_Mutation_p.C1218F|CSMD1_ENST00000602723.1_Missense_Mutation_p.C1218F|CSMD1_ENST00000539096.1_Missense_Mutation_p.C1217F|CSMD1_ENST00000542608.1_Missense_Mutation_p.C1217F|CSMD1_ENST00000537824.1_Missense_Mutation_p.C1217F|CSMD1_ENST00000520002.1_Missense_Mutation_p.C1218F			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1218	Sushi 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGGATCCTCACATTTTACCAG	0.478000													6	12					0.00116845	0.00132867	0.021553	1	0
SI	6476	broad.mit.edu	37	3	164766935	164766935	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:164766935G>C	ENST00000264382.3	-	15	1757	c.1695C>G	c.(1693-1695)agC>agG	p.S565R		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	565	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTATAGCCATGCTGTATCCAT	0.328000										HNSCC(35;0.089)			14	38					0	0	0.024245	0	0
SYNE3	161176	broad.mit.edu	37	14	95922038	95922038	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:95922038C>A	ENST00000334258.5	-	5	827	c.813G>T	c.(811-813)agG>agT	p.R271S	SYNE3_ENST00000557275.1_Missense_Mutation_p.R271S|SYNE3_ENST00000554873.1_Missense_Mutation_p.R28S|SYNE3_ENST00000553340.1_Missense_Mutation_p.R271S	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						ACTCCTCGCCCCTGGGAAAAT	0.532000													10	79					2.17888e-05	2.74377e-05	0.006214	1	0
FOXN4	121643	broad.mit.edu	37	12	109724509	109724509	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:109724509T>A	ENST00000299162.5	-	7	741	c.637A>T	c.(637-639)Agc>Tgc	p.S213C	FOXN4_ENST00000355216.1_Missense_Mutation_p.S33C	NM_213596.2	NP_998761.2	Q96NZ1	FOXN4_HUMAN	forkhead box N4	213					axon extension|embryo development|organ development|pattern specification process|regulation of heart contraction|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(5)|lung(9)|ovary(2)	16						ACAGGCAGGCTGCCTGTCTTG	0.617000													7	17					0	0	0.029380	0	0
NTF3	4908	broad.mit.edu	37	12	5603480	5603480	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:5603480C>A	ENST00000423158.3	+	2	351	c.139C>A	c.(139-141)Ctc>Atc	p.L47I	NTF3_ENST00000535299.1_Intron|NTF3_ENST00000331010.6_Missense_Mutation_p.L34I	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	34					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						GCTCAATTCCCTCATTATTAA	0.433000													15	78					2.31682e-05	2.90671e-05	0.024245	1	0
TRBV5-6	28609	broad.mit.edu	37	7	142131841	142131841	+	RNA	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:142131841G>T	ENST00000390375.2	-	0	77																											GCTCCCAGGAGACAAAGCAGT	0.622000													13	69					7.93312e-07	1.09422e-06	0.020292	1	0
LGR5	8549	broad.mit.edu	37	12	71977581	71977581	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:71977581G>T	ENST00000266674.5	+	18	2102	c.1791G>T	c.(1789-1791)ggG>ggT	p.G597G	RP11-186F10.2_ENST00000546601.1_RNA|LGR5_ENST00000540815.2_Silent_p.G573G|LGR5_ENST00000536515.1_Silent_p.G525G			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	597						integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						TGTTAATTGGGGTCATCGCAG	0.502000													22	90					1.10513e-12	1.91219e-12	0.014323	1	0
DPY19L1	23333	broad.mit.edu	37	7	34971203	34971203	+	Silent	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:34971203T>A	ENST00000310974.4	-	22	2154	c.2010A>T	c.(2008-2010)ctA>ctT	p.L670L		NM_015283.1	NP_056098.1	Q2PZI1	D19L1_HUMAN	dpy-19-like 1 (C. elegans)	670						integral to membrane				endometrium(3)|kidney(5)|large_intestine(8)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	31						TTACAACTTCTAGGACTTTGT	0.413000													22	87					0	0	0.024334	0	0
C9orf72	203228	broad.mit.edu	37	9	27561600	27561600	+	Silent	SNP	A	A	G	rs149801256		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:27561600A>G	ENST00000380003.3	-	5	711	c.648T>C	c.(646-648)caT>caC	p.H216H	C9orf72_ENST00000379997.3_Silent_p.H216H|C9orf72_ENST00000488117.1_5'UTR	NM_001256054.1|NM_018325.3	NP_001242983.1|NP_060795.1	Q96LT7	CI072_HUMAN	chromosome 9 open reading frame 72	216										breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(10)|ovary(4)|pancreas(1)	23		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		GAAAGCCTTCATGACAGCTGT	0.328000													12	30					0	0	0.016723	0	0
TUBBP1	92755	broad.mit.edu	37	8	30210398	30210398	+	RNA	SNP	A	A	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:30210398A>C	ENST00000518096.1	+	0	1010																											CTCACCCAGCAGGTCTTCGAT	0.597000													4	64					0	0	0.014758	0	0
ZNF408	79797	broad.mit.edu	37	11	46727337	46727337	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:46727337C>A	ENST00000311764.2	+	5	2317	c.2087C>A	c.(2086-2088)cCc>cAc	p.P696H		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	696					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GATGCCGCCCCCAGCCTGGTG	0.592000													6	9					8.12818e-05	9.85234e-05	0.029380	1	0
BAI1	575	broad.mit.edu	37	8	143562615	143562615	+	Splice_Site	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:143562615G>C	ENST00000517894.1	+	10	2723	c.1828_splice	c.e10-1	p.G610_splice	BAI1_ENST00000323289.5_Splice_Site_p.G610_splice			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	610					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GTCTCCCCAGGACTCATCCTG	0.622000													8	38					0	0	0.003080	0	0
UBR4	23352	broad.mit.edu	37	1	19525396	19525396	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:19525396G>A	ENST00000375267.2	-	4	408	c.405C>T	c.(403-405)ggC>ggT	p.G135G	UBR4_ENST00000375217.2_Silent_p.G135G|UBR4_ENST00000375254.3_Silent_p.G135G|UBR4_ENST00000375226.2_Silent_p.G135G			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	135					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAGTGCACAGGCCCTTGATTA	0.373000													19	58					0	0	0.006122	0	0
OTOL1	131149	broad.mit.edu	37	3	161216973	161216973	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:161216973G>T	ENST00000327928.4	+	2	379	c.379G>T	c.(379-381)Gct>Tct	p.A127S		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	127	Collagen-like 1.					collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						TAAAGGAGAGGCTGGAAATTT	0.398000													4	18					0.014758	0.0157542	0.014758	1	0
NKAIN4	128414	broad.mit.edu	37	20	61873917	61873917	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:61873917G>T	ENST00000370316.3	-	6	680	c.591C>A	c.(589-591)tcC>tcA	p.S197S	NKAIN4_ENST00000370313.1_Intron|NKAIN4_ENST00000466885.1_5'UTR|NKAIN4_ENST00000370307.2_Silent_p.S135S	NM_152864.3	NP_690603.3	Q8IVV8	NKAI4_HUMAN	Na+/K+ transporting ATPase interacting 4	197						integral to membrane|plasma membrane				endometrium(2)|lung(1)|ovary(1)	4	all_cancers(38;2.72e-09)					ACAAGAGACTGGATGGCTTTT	0.473000													35	195					4.40578e-31	9.54117e-31	0.025465	1	0
NCKAP1	10787	broad.mit.edu	37	2	183867758	183867758	+	Splice_Site	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:183867758C>G	ENST00000360982.2	-	5	1089	c.330_splice	c.e5-1	p.D111_splice	NCKAP1_ENST00000361354.3_Splice_Site_p.D105_splice	NM_205842.1	NP_995314.1	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1	105					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			breast(3)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(11)|lung(16)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	45			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			CAAACATGGTCCTGAAAAGAA	0.289000													5	38					0	0	0.014758	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769608	140769608	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:140769608C>T	ENST00000519479.1	+	1	2157	c.2157C>T	c.(2155-2157)ccC>ccT	p.P719P	PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCTCCAGCCCCGCCTCCTGGA	0.562000													46	152					0	0	0.011902	0	0
CUL3	8452	broad.mit.edu	37	2	225422432	225422432	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:225422432C>G	ENST00000264414.4	-	2	546	c.208G>C	c.(208-210)Gga>Cga	p.G70R	CUL3_ENST00000409096.1_Missense_Mutation_p.G46R|CUL3_ENST00000432260.2_5'UTR|CUL3_ENST00000344951.4_Intron|CUL3_ENST00000409777.1_Missense_Mutation_p.G46R	NM_003590.4	NP_003581.1	Q13618	CUL3_HUMAN	cullin 3	70					cell cycle arrest|cell migration|cyclin catabolic process|cytokinesis|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|mitotic anaphase|negative regulation of Rho protein signal transduction|positive regulation of cell proliferation|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|Golgi apparatus|nucleus|polar microtubule	ubiquitin protein ligase binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	46		all_lung(227;0.00877)|Lung NSC(271;0.011)|Renal(207;0.0112)|all_hematologic(139;0.138)		Epithelial(121;1.58e-11)|all cancers(144;1.43e-08)|Lung(261;0.00863)|LUSC - Lung squamous cell carcinoma(224;0.00902)		AGCTTTTCTCCATGTTTATGC	0.333000													3	27					0	0	0.004672	0	0
MYO18B	84700	broad.mit.edu	37	22	26299729	26299729	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:26299729G>T	ENST00000335473.7	+	31	5329	c.5079G>T	c.(5077-5079)ttG>ttT	p.L1693F	MYO18B_ENST00000407587.2_Missense_Mutation_p.L1694F|MYO18B_ENST00000536101.1_Missense_Mutation_p.L1693F|MYO18B_ENST00000536204.1_3'UTR	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1693	Gln-rich.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TCTGGAAGTTGGAATCCAGCG	0.557000													5	13					1.23904e-05	1.58971e-05	0.014758	1	0
FAT3	120114	broad.mit.edu	37	11	92531099	92531099	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:92531099C>T	ENST00000298047.6	+	9	4937	c.4920C>T	c.(4918-4920)tcC>tcT	p.S1640S	FAT3_ENST00000525166.1_Silent_p.S1490S|FAT3_ENST00000409404.2_Silent_p.S1640S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1640	Cadherin 15.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TTGTCCTATCCATCAAAGTCA	0.478000										TCGA Ovarian(4;0.039)			19	51					0	0	0.007413	0	0
PODN	127435	broad.mit.edu	37	1	53544622	53544622	+	Silent	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:53544622G>C	ENST00000371500.3	+	10	1868	c.1527G>C	c.(1525-1527)ctG>ctC	p.L509L	PODN_ENST00000312553.5_Silent_p.L528L|PODN_ENST00000395871.2_Silent_p.L386L|RP11-334A14.5_ENST00000447867.1_RNA	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	480					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						TGCGTGAGCTGTACCTCACCA	0.662000													3	5					0	0	0.004672	0	0
GPR26	2849	broad.mit.edu	37	10	125426472	125426472	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:125426472C>A	ENST00000284674.1	+	1	602	c.549C>A	c.(547-549)ctC>ctA	p.L183L		NM_153442.3	NP_703143.1	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	183					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	20		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				GCTTCCTGCTCTCCTTCGTCG	0.642000													3	20					0.00024832	0.000289636	0.009096	1	0
RBM6	10180	broad.mit.edu	37	3	50112758	50112758	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:50112758G>T	ENST00000443081.1	+	20	3764	c.2845G>T	c.(2845-2847)Gag>Tag	p.E949*	RBM6_ENST00000422955.1_Nonsense_Mutation_p.E559*|RBM6_ENST00000539992.1_Nonsense_Mutation_p.E423*|RBM6_ENST00000266022.4_Nonsense_Mutation_p.E1081*|RBM6_ENST00000421682.1_Nonsense_Mutation_p.E77*|RBM6_ENST00000442092.1_Nonsense_Mutation_p.E559*			P78332	RBM6_HUMAN	RNA binding motif protein 6	1081					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding	p.E1081Q(1)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		GGCTTCATCAGAGGAGGTAAA	0.483000													7	69					1.06961e-07	1.55747e-07	0.003080	1	0
ADAMTS13	11093	broad.mit.edu	37	9	136310172	136310172	+	Splice_Site	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:136310172A>T	ENST00000371929.3	+	20	3053	c.2610_splice	c.e20+1	p.H870_splice	ADAMTS13_ENST00000485925.1_3'UTR|ADAMTS13_ENST00000371916.1_3'UTR|ADAMTS13_ENST00000536611.1_3'UTR|ADAMTS13_ENST00000356589.2_Splice_Site_p.H839_splice|ADAMTS13_ENST00000355699.2_Splice_Site_p.H870_splice	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	870					cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GGCTGGGGCCATGTGAGTGCC	0.647000													4	13					0	0	0.014758	0	0
KRBOX4	55634	broad.mit.edu	37	X	46322201	46322201	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:46322201G>C	ENST00000344302.4	+	4	665	c.34G>C	c.(34-36)Gac>Cac	p.D12H	KRBOX4_ENST00000298190.6_Missense_Mutation_p.D12H|KRBOX4_ENST00000377919.2_Missense_Mutation_p.D12H|KRBOX4_ENST00000478600.1_Missense_Mutation_p.D12H|KRBOX4_ENST00000360017.5_Missense_Mutation_p.D12H|KRBOX4_ENST00000487081.1_Missense_Mutation_p.D12H	NM_001129898.1|NM_017776.2	NP_001123370.1|NP_060246.2			KRAB box domain containing 4																		GACCTTCAAGGACGTGTTTGT	0.547000													8	34					0	0	0.003080	0	0
LCT	3938	broad.mit.edu	37	2	136569890	136569890	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:136569890C>A	ENST00000264162.2	-	7	2354	c.2344G>T	c.(2344-2346)Gtg>Ttg	p.V782L		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	782	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCCTTGAGCACCTCATTGATA	0.408000													8	118					2.17888e-05	2.74377e-05	0.006214	1	0
RBM6	10180	broad.mit.edu	37	3	50036934	50036934	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:50036934G>A	ENST00000443081.1	+	6	2068	c.1149G>A	c.(1147-1149)atG>atA	p.M383I	RBM6_ENST00000422955.1_Intron|RBM6_ENST00000539992.1_Intron|RBM6_ENST00000266022.4_Missense_Mutation_p.M515I|RBM6_ENST00000442092.1_Intron|RBM6_ENST00000441115.1_3'UTR			P78332	RBM6_HUMAN	RNA binding motif protein 6	515					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		TCGGATGCATGGAGGCCAACC	0.433000													16	95					0	0	0.033300	0	0
SLC17A8	246213	broad.mit.edu	37	12	100784891	100784891	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:100784891C>A	ENST00000323346.5	+	3	780	c.467C>A	c.(466-468)gCt>gAt	p.A156D	SLC17A8_ENST00000392989.3_Missense_Mutation_p.A156D	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	156					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						AAGTTTGCTGCTAACAGGTAA	0.388000													16	76					5.01169e-05	6.19628e-05	0.033300	1	0
SEMA4D	10507	broad.mit.edu	37	9	91994486	91994486	+	Silent	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:91994486C>G	ENST00000450295.1	-	16	2498	c.1722G>C	c.(1720-1722)ctG>ctC	p.L574L	SEMA4D_ENST00000422704.2_Silent_p.L574L|SEMA4D_ENST00000339861.4_Intron|SEMA4D_ENST00000343780.4_Intron|SEMA4D_ENST00000455551.2_Intron|SEMA4D_ENST00000420987.1_Intron|SEMA4D_ENST00000356444.2_Silent_p.L574L|SEMA4D_ENST00000438547.2_Silent_p.L574L			Q92854	SEM4D_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D	574	Ig-like C2-type.				anti-apoptosis|axon guidance|cell adhesion|immune response	integral to membrane|plasma membrane	receptor activity|receptor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(8)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34						GGGAGCATTTCAGTTCCGCTG	0.483000													19	180					0	0	0.012319	0	0
GGA3	23163	broad.mit.edu	37	17	73235895	73235895	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:73235895C>A	ENST00000245541.6	-	13	1774	c.1558G>T	c.(1558-1560)Gat>Tat	p.D520Y	GGA3_ENST00000578348.1_Missense_Mutation_p.D398Y|GGA3_ENST00000351904.7_Missense_Mutation_p.D487Y|GGA3_ENST00000538886.1_Missense_Mutation_p.D398Y|GGA3_ENST00000582717.1_Missense_Mutation_p.D448Y|GGA3_ENST00000582486.1_Missense_Mutation_p.D448Y	NM_138619.2	NP_619525.1	Q9NZ52	GGA3_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	520	Unstructured hinge.				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			breast(2)|endometrium(3)|large_intestine(4)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	20			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			AGAAGCTGATCGAGGGCATCC	0.587000													13	33					9.05144e-12	1.53109e-11	0.016723	1	0
OLFML3	56944	broad.mit.edu	37	1	114524186	114524186	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:114524186C>A	ENST00000369551.1	+	4	1244	c.956C>A	c.(955-957)cCt>cAt	p.P319H	OLFML3_ENST00000320334.4_Missense_Mutation_p.P339H|OLFML3_ENST00000393300.2_Missense_Mutation_p.P319H|OLFML3_ENST00000491700.1_3'UTR			Q9NRN5	OLFL3_HUMAN	olfactomedin-like 3	339	Olfactomedin-like.				multicellular organismal development	extracellular region				breast(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)|urinary_tract(1)	14	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AACACCCGTCCTGCCAGTCGG	0.587000													7	59					0.0293803	0.0309267	0.029380	1	0
ARHGEF40	55701	broad.mit.edu	37	14	21549125	21549125	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:21549125G>T	ENST00000298694.4	+	13	2717	c.2590G>T	c.(2590-2592)Gtt>Ttt	p.V864F	ARHGEF40_ENST00000298693.3_Missense_Mutation_p.V864F			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	864					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						GCTGGAGCAGGTTGAGAGTGG	0.607000													21	113					3.01185e-09	4.70818e-09	0.021523	1	0
OTOF	9381	broad.mit.edu	37	2	26690031	26690031	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:26690031C>A	ENST00000272371.2	-	35	4424	c.4298G>T	c.(4297-4299)cGg>cTg	p.R1433L	OTOF_ENST00000402415.3_Missense_Mutation_p.R743L|OTOF_ENST00000339598.3_Missense_Mutation_p.R666L|OTOF_ENST00000338581.6_Missense_Mutation_p.R666L|OTOF_ENST00000403946.3_Missense_Mutation_p.R1433L	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1433					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTCTTGCCCCGAAGCAAGTT	0.602000													14	57					3.27435e-08	4.86148e-08	0.020292	1	0
OR10V1	390201	broad.mit.edu	37	11	59481200	59481200	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:59481200C>A	ENST00000307552.2	-	1	137	c.119G>T	c.(118-120)gGt>gTt	p.G40V	STX3_ENST00000300150.7_5'UTR	NM_001005324.1	NP_001005324.1	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V, member 1	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|liver(1)|lung(10)|skin(1)	16						AGCATTTCCACCGAGGCTGGT	0.443000													16	25					9.16793e-09	1.40094e-08	0.033300	1	0
BAGE2	85319	broad.mit.edu	37	21	11049539	11049539	+	RNA	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr21:11049539G>C	ENST00000470054.1	-	0	569									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCCATGATAGTGCTGACCAC	0.448000													8	132					0	0	0.020292	0	0
STAG1	10274	broad.mit.edu	37	3	136141303	136141303	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:136141303A>C	ENST00000383202.2	-	19	2242	c.1986T>G	c.(1984-1986)atT>atG	p.I662M	STAG1_ENST00000536929.1_Missense_Mutation_p.I246M|STAG1_ENST00000236698.5_Missense_Mutation_p.I662M|STAG1_ENST00000434713.2_Missense_Mutation_p.I436M	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	662					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						CAAACTCATCAATCAGCTGGC	0.358000													22	72					0	0	0.012319	0	0
BAI1	575	broad.mit.edu	37	8	143562715	143562715	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:143562715G>C	ENST00000517894.1	+	10	2823	c.1929G>C	c.(1927-1929)caG>caC	p.Q643H	BAI1_ENST00000323289.5_Missense_Mutation_p.Q643H			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	643					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GAAACATCCAGATGATGGTGA	0.607000													9	34					0	0	0.008291	0	0
C1orf173	127254	broad.mit.edu	37	1	75038906	75038906	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:75038906C>A	ENST00000326665.5	-	14	2706	c.2488G>T	c.(2488-2490)Gag>Tag	p.E830*	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	830	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGAGGGATCTCCCTTTTTTCT	0.572000													23	78					7.87624e-14	1.42443e-13	0.016522	1	0
ZNF205	7755	broad.mit.edu	37	16	3170215	3170215	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:3170215C>T	ENST00000382192.3	+	7	1759	c.1554C>T	c.(1552-1554)aaC>aaT	p.N518N	RP11-473M20.14_ENST00000575139.1_RNA|RP11-473M20.14_ENST00000576490.1_RNA|ZNF205_ENST00000219091.4_Silent_p.N518N	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	518					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						GGCGCTCCAACCTGCACCGGC	0.731000													10	51					0	0	0.006214	0	0
INCENP	3619	broad.mit.edu	37	11	61897761	61897761	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:61897761G>T	ENST00000394818.3	+	4	964	c.762G>T	c.(760-762)gcG>gcT	p.A254A	INCENP_ENST00000278849.4_Silent_p.A254A	NM_001040694.1	NP_001035784.1	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	254					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						GGCGGTCTGCGTCTAAGCTCA	0.647000													26	39					3.6726e-16	7.05472e-16	0.021523	1	0
COL25A1	84570	broad.mit.edu	37	4	109805343	109805343	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:109805343C>A	ENST00000399132.1	-	19	1541	c.1011G>T	c.(1009-1011)ccG>ccT	p.P337P	COL25A1_ENST00000399126.1_Silent_p.P337P|COL25A1_ENST00000399127.1_Silent_p.P333P	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	337	Collagen-like 4.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CCTTTATCCCCGGAAGTCCAG	0.408000													19	32					8.28177e-16	1.57748e-15	0.007413	1	0
TAL1	6886	broad.mit.edu	37	1	47685528	47685528	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:47685528G>T	ENST00000371883.3	-	4	1442	c.866C>A	c.(865-867)cCc>cAc	p.P289H	TAL1_ENST00000459729.1_5'UTR|TAL1_ENST00000371884.2_Missense_Mutation_p.P287H|TAL1_ENST00000294339.3_Missense_Mutation_p.P287H			P17542	TAL1_HUMAN	T-cell acute lymphocytic leukemia 1	287					basophil differentiation|cell fate commitment|cell proliferation|embryonic hemopoiesis|erythrocyte differentiation|megakaryocyte differentiation|positive regulation of cell division|positive regulation of chromatin assembly or disassembly|positive regulation of erythrocyte differentiation|positive regulation of mitotic cell cycle|positive regulation of protein complex assembly|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	E-box binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity			haematopoietic_and_lymphoid_tissue(1)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	15						GCTGGAGTTGGGGGAAAGCAC	0.711000			T	"""TRD@, SIL"""	lymphoblastic leukemia/biphasic								5	32					1.23904e-05	1.58971e-05	0.014758	1	0
FAM151A	338094	broad.mit.edu	37	1	55077354	55077354	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:55077354G>T	ENST00000302250.2	-	6	1025	c.865C>A	c.(865-867)Cgg>Agg	p.R289R	ACOT11_ENST00000371316.3_Intron|FAM151A_ENST00000371304.2_Silent_p.R289R	NM_176782.2	NP_788954.2	Q8WW52	F151A_HUMAN	family with sequence similarity 151, member A	289						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	12						GTGTTATCCCGGACGTAGAGC	0.577000													18	85					1.99824e-07	2.84864e-07	0.033300	1	0
POTEE	445582	broad.mit.edu	37	2	132021450	132021450	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:132021450G>C	ENST00000356920.5	+	15	2516	c.2422G>C	c.(2422-2424)Gcc>Ccc	p.A808P	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000303908.3_Intron|PLEKHB2_ENST00000404460.1_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	808	Actin-like.						ATP binding										GCTGACCGAGGCCCCCCTGAA	0.597000													33	136					0	0	0.023175	0	0
NELFCD	51497	broad.mit.edu	37	20	57561906	57561906	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:57561906C>G	ENST00000602795.1	+	3	376	c.328C>G	c.(328-330)Ctc>Gtc	p.L110V	NELFCD_ENST00000344018.3_Missense_Mutation_p.L101V					negative elongation factor complex member C/D																		GGCCGAGTGGCTCATTCAGAC	0.483000													26	70					0	0	0.027356	0	0
CENPF	1063	broad.mit.edu	37	1	214818608	214818608	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:214818608G>C	ENST00000366955.3	+	13	5863	c.5695G>C	c.(5695-5697)Gat>Cat	p.D1899H		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	1995					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		GAGATTTCTTGATGTGGAAAA	0.428000													17	66					0	0	0.006122	0	0
IGLV5-48	28780	broad.mit.edu	37	22	22707610	22707610	+	RNA	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:22707610G>T	ENST00000390293.1	+	0	198																											GCCCTCCCCGGTATCTCCTGA	0.542000													41	74					1.47244e-24	3.05263e-24	0.025465	1	0
DCAF8L2	347442	broad.mit.edu	37	X	27765740	27765740	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:27765740T>A	ENST00000451261.2	+	5	1127	c.728T>A	c.(727-729)cTg>cAg	p.L243Q		NM_001136533.1	NP_001130005.1			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|endometrium(9)|kidney(3)|lung(7)|pancreas(1)|skin(3)	24						GGCACCCGGCTGGCCAGTAGC	0.532000													4	26					0	0	0.009096	0	0
UNC79	57578	broad.mit.edu	37	14	94156483	94156483	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:94156483G>T	ENST00000553484.1	+	47	7443	c.7289G>T	c.(7288-7290)tGt>tTt	p.C2430F	UNC79_ENST00000555664.1_Missense_Mutation_p.C2369F|UNC79_ENST00000393151.2_Missense_Mutation_p.C2408F|UNC79_ENST00000256339.4_Missense_Mutation_p.C2231F			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	2408						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TTCATTGAGTGTGTCTCCCAT	0.448000													21	61					3.62473e-10	5.79957e-10	0.012319	1	0
TMED3	23423	broad.mit.edu	37	15	79614470	79614470	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:79614470C>T	ENST00000299705.5	+	3	756	c.568C>T	c.(568-570)Ctg>Ttg	p.L190L	TMED3_ENST00000558562.1_3'UTR|TMED3_ENST00000536821.1_Intron|TMED3_ENST00000424155.2_Intron	NM_007364.2	NP_031390.1	Q9Y3Q3	TMED3_HUMAN	transmembrane emp24 protein transport domain containing 3	190					protein transport	ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane				large_intestine(3)|lung(4)|ovary(1)|skin(1)	9						GACGATTGCCCTGTTCGTGGT	0.582000													17	66					0	0	0.028581	0	0
SETBP1	26040	broad.mit.edu	37	18	42531871	42531871	+	Missense_Mutation	SNP	G	G	A	rs140028039		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr18:42531871G>A	ENST00000282030.5	+	4	2862	c.2566G>A	c.(2566-2568)Gtg>Atg	p.V856M		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	856						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCTGTCCCCTGTGAGCGAGTC	0.572000									Schinzel-Giedion syndrome				14	15					0	0	0.020292	0	0
SLC9A4	389015	broad.mit.edu	37	2	103095489	103095489	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:103095489C>G	ENST00000295269.4	+	2	905	c.448C>G	c.(448-450)Ccc>Gcc	p.P150A		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	150					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GCCCACCCGGCCCTTCTTTGA	0.592000													7	42					0	0	0.003080	0	0
CACNA2D1	781	broad.mit.edu	37	7	81599236	81599236	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:81599236C>A	ENST00000356860.3	-	28	2607	c.2269G>T	c.(2269-2271)Gat>Tat	p.D757Y	CACNA2D1_ENST00000356253.5_Missense_Mutation_p.D769Y|CACNA2D1_ENST00000535308.1_Intron	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	769						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TTATCATTATCTAGGCTCCTT	0.338000													15	62					2.23348e-06	3.00152e-06	0.028581	1	0
IL36G	56300	broad.mit.edu	37	2	113737597	113737597	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:113737597G>T	ENST00000259205.4	+	4	241	c.172G>T	c.(172-174)Gtt>Ttt	p.V58F	IL36G_ENST00000376489.2_Missense_Mutation_p.V23F	NM_019618.2	NP_062564.1	Q9NZH8	IL36G_HUMAN	interleukin 36, gamma	58					cell-cell signaling	extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						CACTGTTGCTGTTATCACATG	0.413000													5	92					1.06961e-07	1.55747e-07	0.003080	1	0
LRP2	4036	broad.mit.edu	37	2	169995821	169995821	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:169995821G>A	ENST00000263816.3	-	74	13613	c.13328C>T	c.(13327-13329)gCa>gTa	p.A4443V		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4443					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GAAGAATCCTGCAATTGCCAG	0.483000													9	60					0	0	0.006214	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89417046	89417046	+	RNA	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:89417046C>A	ENST00000490686.1	-	0	164																											CCTGACTTGCCCGGCAAGTGA	0.512000													40	160					1.00776e-21	2.05172e-21	0.014410	1	0
MROH2B	133558	broad.mit.edu	37	5	41038949	41038949	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:41038949G>T	ENST00000399564.4	-	21	2553	c.2103C>A	c.(2101-2103)gtC>gtA	p.V701V	MROH2B_ENST00000506092.2_Silent_p.V256V	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		AGATGACCATGACATCTGTCT	0.453000													8	96					0.00307968	0.00343872	0.003080	1	0
CNST	163882	broad.mit.edu	37	1	246823556	246823556	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:246823556G>C	ENST00000366513.4	+	10	2161	c.1892G>C	c.(1891-1893)gGa>gCa	p.G631A		NM_152609.2	NP_689822.2	Q6PJW8	CNST_HUMAN	consortin, connexin sorting protein	631					positive regulation of Golgi to plasma membrane protein transport	integral to membrane|plasma membrane|protein complex|trans-Golgi network|transport vesicle	connexin binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|urinary_tract(2)	28						GATACTGTAGGAGATCATCCT	0.403000													31	106					0	0	0.010818	0	0
EYA4	2070	broad.mit.edu	37	6	133783546	133783546	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:133783546G>T	ENST00000367895.5	+	8	975	c.511G>T	c.(511-513)Ggg>Tgg	p.G171W	EYA4_ENST00000452339.2_Missense_Mutation_p.G117W|EYA4_ENST00000431403.2_Missense_Mutation_p.G171W|EYA4_ENST00000430974.2_Missense_Mutation_p.G117W|EYA4_ENST00000531901.1_Missense_Mutation_p.G171W|EYA4_ENST00000355286.6_Missense_Mutation_p.G148W|EYA4_ENST00000525849.1_Missense_Mutation_p.G148W|EYA4_ENST00000355167.3_Missense_Mutation_p.G171W	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	171					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity	p.G171W(2)		breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TCAGTATTCGGGGATGCAGCA	0.473000													29	100					1.39806e-14	2.56247e-14	0.037714	1	0
ZCCHC11	23318	broad.mit.edu	37	1	52981709	52981709	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:52981709C>A	ENST00000371544.3	-	3	998	c.736G>T	c.(736-738)Gaa>Taa	p.E246*	ZCCHC11_ENST00000355809.4_Nonsense_Mutation_p.E246*|ZCCHC11_ENST00000371541.1_5'UTR|ZCCHC11_ENST00000257177.4_Nonsense_Mutation_p.E246*	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	246					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TTATTAGATTCATCATTCTTC	0.318000													9	35					0.00448238	0.00494808	0.004482	1	0
MAP4K2	5871	broad.mit.edu	37	11	64564575	64564575	+	Splice_Site	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:64564575C>T	ENST00000294066.2	-	19	1457		c.e19+1		MAP4K2_ENST00000377350.3_Splice_Site	NM_004579.3	NP_004570.2	Q12851	M4K2_HUMAN	mitogen-activated protein kinase kinase kinase kinase 2						activation of JUN kinase activity|immune response|positive regulation of JNK cascade|vesicle targeting	basolateral plasma membrane|Golgi membrane|soluble fraction	ATP binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity|small GTPase regulator activity			cervix(1)|lung(3)|ovary(1)|pancreas(1)|urinary_tract(2)	8						CACCCTCTTACCTCAGGATCC	0.652000													13	31					0	0	0.016723	0	0
ECHS1	1892	broad.mit.edu	37	10	135184202	135184202	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:135184202T>A	ENST00000368547.3	-	2	503	c.148A>T	c.(148-150)Atc>Ttc	p.I50F		NM_004092.3	NP_004083.3	P30084	ECHM_HUMAN	enoyl CoA hydratase, short chain, 1, mitochondrial	50					fatty acid beta-oxidation	mitochondrial matrix	enoyl-CoA hydratase activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|skin(1)	10		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;1.62e-06)|OV - Ovarian serous cystadenocarcinoma(35;5.75e-06)|Epithelial(32;7.58e-06)		TTCAGTTGGATCAACCCCACG	0.532000													10	28					0	0	0.008291	0	0
SNHG14	104472715	broad.mit.edu	37	15	25488596	25488596	+	RNA	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:25488596T>A	ENST00000453082.2	+	0	2224					NR_003343.1																						GAGGAAGACTTGTGTTGGGCC	0.602000													5	24					0	0	0.014758	0	0
PCDHB6	56130	broad.mit.edu	37	5	140530589	140530589	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:140530589C>T	ENST00000231136.1	+	1	751	c.751C>T	c.(751-753)Cct>Tct	p.P251S	PCDHB6_ENST00000543635.1_Missense_Mutation_p.P115S	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		251	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCACAAGTCCCTGAGAACAA	0.527000													7	40					0	0	0.029380	0	0
YIPF1	54432	broad.mit.edu	37	1	54337113	54337113	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:54337113C>A	ENST00000072644.1	-	7	749	c.413G>T	c.(412-414)gGg>gTg	p.G138V	YIPF1_ENST00000469457.1_5'UTR|YIPF1_ENST00000371399.1_5'UTR|YIPF1_ENST00000539954.1_Missense_Mutation_p.G163V	NM_018982.4	NP_061855.1	Q9Y548	YIPF1_HUMAN	Yip1 domain family, member 1	138						integral to membrane|transport vesicle				endometrium(2)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|skin(1)|urinary_tract(2)	19						GGAAAGATTCCCACTAATTGC	0.423000													27	86					9.39395e-14	1.68992e-13	0.030593	1	0
NOS1	4842	broad.mit.edu	37	12	117662918	117662918	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:117662918C>A	ENST00000317775.6	-	25	4414	c.3729G>T	c.(3727-3729)cgG>cgT	p.R1243R	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Silent_p.R1277R	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1243					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTTGGGGGTTCCGGGGCAGGT	0.542000													21	99					1.28384e-07	1.84569e-07	0.012319	1	0
KBTBD8	84541	broad.mit.edu	37	3	67054223	67054223	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:67054223C>T	ENST00000295568.4	+	3	885	c.754C>T	c.(754-756)Cag>Tag	p.Q252*	KBTBD8_ENST00000460576.1_Intron|KBTBD8_ENST00000417314.2_Nonsense_Mutation_p.Q278*|KBTBD8_ENST00000469661.1_3'UTR	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	278	BACK.									breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		TGGCTGTACACAGAGGCTTGG	0.428000													23	101					0	0	0.018920	0	0
BST1	683	broad.mit.edu	37	4	15707203	15707203	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:15707203T>A	ENST00000382346.3	+	3	348	c.299T>A	c.(298-300)gTg>gAg	p.V100E	BST1_ENST00000265016.4_Missense_Mutation_p.V85E			Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1	85					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity			central_nervous_system(1)|large_intestine(1)|lung(2)|stomach(3)|urinary_tract(1)	8						CCCTGCTCCGTGCTGCCCTCA	0.473000													16	80					0	0	0.028581	0	0
ZNF98	148198	broad.mit.edu	37	19	22574517	22574517	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:22574517G>T	ENST00000357774.5	-	4	1641	c.1520C>A	c.(1519-1521)aCa>aAa	p.T507K		NM_001098626.1	NP_001092096.1	A6NK75	ZNF98_HUMAN	zinc finger protein 98	507					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37		all_cancers(12;0.0536)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00542)|Hepatocellular(1079;0.244)				CATCTTATGTGTAGTAAGGTG	0.383000													24	62					7.07758e-08	1.03723e-07	0.024334	1	0
MAP3K19	80122	broad.mit.edu	37	2	135745227	135745227	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:135745227G>T	ENST00000375845.3	-	7	1245	c.1215C>A	c.(1213-1215)agC>agA	p.S405R	MAP3K19_ENST00000392918.3_Intron|MAP3K19_ENST00000358371.4_Missense_Mutation_p.S292R|MAP3K19_ENST00000392917.3_Intron|MAP3K19_ENST00000375844.3_Intron|MAP3K19_ENST00000392915.1_Missense_Mutation_p.S422R|MAP3K19_ENST00000315513.3_5'UTR	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		CTTCATCCTGGCTTGGAGTTA	0.348000													18	88					5.03518e-11	8.25042e-11	0.007413	1	0
NF1	4763	broad.mit.edu	37	17	29528427	29528427	+	Splice_Site	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:29528427A>G	ENST00000358273.4	+	11	1568		c.e11-1		NF1_ENST00000431387.4_Splice_Site|NF1_ENST00000356175.3_Splice_Site	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1						actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(6)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		CTTTTTCTATAGATCTGCCTG	0.308000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			58	80					0	0	0.014410	0	0
GATA6	2627	broad.mit.edu	37	18	19762969	19762969	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr18:19762969A>C	ENST00000269216.3	+	6	1862	c.1585A>C	c.(1585-1587)Aat>Cat	p.N529H	GATA6_ENST00000581694.1_Missense_Mutation_p.N529H	NM_005257.4	NP_005248.2	Q92908	GATA6_HUMAN	GATA binding protein 6	529					blood coagulation|cardiac vascular smooth muscle cell differentiation|cellular response to hypoxia|intestinal epithelial cell differentiation|male gonad development|negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor-beta1 production|negative regulation of transforming growth factor-beta2 production|outflow tract septum morphogenesis|positive regulation of angiogenesis|positive regulation of cell cycle arrest|positive regulation of transcription from RNA polymerase II promoter|response to drug|response to growth factor stimulus		protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|skin(1)	18	all_cancers(21;0.00271)|all_epithelial(16;7.31e-05)|Ovarian(2;0.116)|Lung NSC(20;0.123)|all_lung(20;0.246)		STAD - Stomach adenocarcinoma(5;0.106)			TTGCAGCAAAAATACTTCCCC	0.373000													15	54					0	0	0.008871	0	0
CD109	135228	broad.mit.edu	37	6	74530266	74530266	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:74530266A>G	ENST00000437994.2	+	32	4521	c.4090A>G	c.(4090-4092)Ata>Gta	p.I1364V	CD109_ENST00000287097.5_Missense_Mutation_p.I1381V|CD109_ENST00000422508.2_Missense_Mutation_p.I1304V	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	1381						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TTCAGTGTCCATAGTGGATTA	0.353000													13	42					0	0	0.020292	0	0
SRSF7	6432	broad.mit.edu	37	2	38975201	38975201	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:38975201G>A	ENST00000313117.6	-	5	797	c.560C>T	c.(559-561)tCg>tTg	p.S187L	SRSF7_ENST00000446327.2_Missense_Mutation_p.S187L|SRSF7_ENST00000409276.1_Missense_Mutation_p.S187L	NM_001031684.2|NM_001195446.1	NP_001026854.1|NP_001182375.1	Q16629	SRSF7_HUMAN	serine/arginine-rich splicing factor 7	187	6 X 8 AA repeats of R-R-S-R-S-X-S-X.|Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						GAAATACCTCGATCCTTTTAT	0.388000													10	49					0	0	0.008291	0	0
QSER1	79832	broad.mit.edu	37	11	32953390	32953390	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:32953390T>A	ENST00000399302.2	+	4	534	c.199T>A	c.(199-201)Ttc>Atc	p.F67I	QSER1_ENST00000527250.1_3'UTR|QSER1_ENST00000527788.1_Missense_Mutation_p.F67I	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	67										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					TCCCACCACCTTCAGCAATAG	0.443000													42	62					0	0	0.011902	0	0
EMR2	30817	broad.mit.edu	37	19	14876179	14876179	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:14876179C>A	ENST00000315576.3	-	10	1310	c.859G>T	c.(859-861)Gac>Tac	p.D287Y	EMR2_ENST00000596991.2_Missense_Mutation_p.D287Y|EMR2_ENST00000594076.1_Missense_Mutation_p.D194Y|EMR2_ENST00000353005.1_Missense_Mutation_p.D145Y|EMR2_ENST00000346057.1_Missense_Mutation_p.D238Y|EMR2_ENST00000594294.1_Missense_Mutation_p.D238Y|EMR2_ENST00000601345.1_Missense_Mutation_p.D287Y|EMR2_ENST00000392967.2_Missense_Mutation_p.D287Y|EMR2_ENST00000595839.1_Missense_Mutation_p.D145Y|EMR2_ENST00000392965.3_Missense_Mutation_p.D287Y|EMR2_ENST00000353876.1_Missense_Mutation_p.D194Y|EMR2_ENST00000392964.3_Missense_Mutation_p.D26Y	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	287					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						CTGCCCAGGTCCTGGACTTTG	0.592000													11	101					1.49906e-05	1.91609e-05	0.020292	1	0
KRT6B	3854	broad.mit.edu	37	12	52843597	52843597	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:52843597G>C	ENST00000252252.3	-	4	904	c.857C>G	c.(856-858)gCc>gGc	p.A286G		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	286	Coil 1B.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		GTCTGCCTTGGCTTGCAGTTC	0.488000													12	98					0	0	0.013537	0	0
SLC26A5	375611	broad.mit.edu	37	7	103051925	103051925	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:103051925C>G	ENST00000306312.3	-	6	773	c.512G>C	c.(511-513)aGa>aCa	p.R171T	SLC26A5_ENST00000393727.1_Missense_Mutation_p.R171T|SLC26A5_ENST00000393723.1_Missense_Mutation_p.R171T|SLC26A5_ENST00000432958.2_Missense_Mutation_p.R171T|SLC26A5_ENST00000393730.1_Missense_Mutation_p.R171T|SLC26A5_ENST00000356767.4_Missense_Mutation_p.R171T|SLC26A5_ENST00000354356.4_5'UTR|SLC26A5_ENST00000339444.6_Missense_Mutation_p.R171T|SLC26A5_ENST00000393729.1_Missense_Mutation_p.R134T|SLC26A5_ENST00000393735.2_Missense_Mutation_p.R171T	NM_198999.2	NP_945350.1	P58743	S26A5_HUMAN	solute carrier family 26 (anion exchanger), member 5	171					regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			endometrium(5)|kidney(2)|large_intestine(9)|lung(15)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)	43						CAAGGCATCTCTGGCCTCTGT	0.448000													31	77					0	0	0.009535	0	0
DIEXF	27042	broad.mit.edu	37	1	210004186	210004186	+	Silent	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:210004186A>G	ENST00000491415.2	+	3	243	c.186A>G	c.(184-186)tcA>tcG	p.S62S		NM_014388.6	NP_055203.4	Q68CQ4	DIEXF_HUMAN	digestive organ expansion factor homolog (zebrafish)	62					multicellular organismal development	nucleus				breast(6)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(15)|large_intestine(7)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(2)	53						AAAGCGACTCAGAGAGTGAAC	0.378000													16	55					0	0	0.006122	0	0
FREM2	341640	broad.mit.edu	37	13	39343846	39343846	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr13:39343846G>A	ENST00000280481.7	+	4	5758	c.5542G>A	c.(5542-5544)Gag>Aag	p.E1848K		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	1848	Calx-beta 1.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TGGGGAGCATGAGCAGTCTGA	0.552000													5	35					0	0	0.014758	0	0
MAP4K1	11184	broad.mit.edu	37	19	39087686	39087686	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:39087686G>C	ENST00000591517.1	-	25	1957	c.1929C>G	c.(1927-1929)ttC>ttG	p.F643L	CTB-186G2.1_ENST00000589557.1_RNA|MAP4K1_ENST00000396857.2_Missense_Mutation_p.F643L|MAP4K1_ENST00000589130.1_Missense_Mutation_p.F639L|MAP4K1_ENST00000586296.1_Intron	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	643	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GGACAAGCAGGAATTTGTTCA	0.592000													4	81					0	0	0.009096	0	0
SLITRK3	22865	broad.mit.edu	37	3	164905951	164905951	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:164905951G>T	ENST00000475390.1	-	2	3111	c.2668C>A	c.(2668-2670)Cca>Aca	p.P890T	SLITRK3_ENST00000241274.3_Missense_Mutation_p.P890T			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	890						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						GCAGGCTGTGGCCTCTCTCGA	0.562000										HNSCC(40;0.11)			13	62					5.50884e-06	7.2738e-06	0.013537	1	0
CYP26B1	56603	broad.mit.edu	37	2	72362450	72362450	+	Silent	SNP	G	G	C	rs143775993		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:72362450G>C	ENST00000001146.2	-	3	731	c.528C>G	c.(526-528)ccC>ccG	p.P176P	CYP26B1_ENST00000412253.1_5'UTR|CYP26B1_ENST00000546307.1_Silent_p.P101P	NM_001277742.1|NM_019885.2	NP_001264671.1|NP_063938.1	Q9NR63	CP26B_HUMAN	cytochrome P450, family 26, subfamily B, polypeptide 1	176					cell fate determination|embryonic limb morphogenesis|male meiosis|negative regulation of retinoic acid receptor signaling pathway|proximal/distal pattern formation|retinoic acid catabolic process|spermatogenesis|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			breast(1)|kidney(3)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)	28						TGATGGCCTCGGGGTGGCTGC	0.627000													12	79					0	0	0.010729	0	0
CPED1	79974	broad.mit.edu	37	7	120935692	120935692	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:120935692A>G	ENST00000310396.5	+	23	3534	c.3067A>G	c.(3067-3069)Aaa>Gaa	p.K1023E		NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		GTGTGCAAATAAAAGGACTAT	0.483000													18	74					0	0	0.007413	0	0
VWA3A	146177	broad.mit.edu	37	16	22142978	22142978	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:22142978C>G	ENST00000389398.5	+	19	1896	c.1800C>G	c.(1798-1800)gaC>gaG	p.D600E	VWA3A_ENST00000389397.4_5'UTR	NM_173615.3	NP_775886.3	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	600	VWFA 1.					extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		TGGAAGTAGACTTCAAGGACA	0.607000													11	22					0	0	0.013537	0	0
PADI3	51702	broad.mit.edu	37	1	17575706	17575706	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:17575706C>A	ENST00000375460.3	+	1	114	c.74C>A	c.(73-75)aCc>aAc	p.T25N		NM_016233.2	NP_057317.2	Q9ULW8	PADI3_HUMAN	peptidyl arginine deiminase, type III	25					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|liver(2)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;1.17e-05)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	GGCGTGGAGACCCTCGTGGAC	0.612000													13	47					9.31168e-06	1.22003e-05	0.016723	1	0
MIPOL1	145282	broad.mit.edu	37	14	37754522	37754522	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:37754522G>T	ENST00000327441.7	+	8	959		c.e8-1		MIPOL1_ENST00000396294.2_Splice_Site|MIPOL1_ENST00000556451.1_Splice_Site|MIPOL1_ENST00000537471.1_Splice_Site|MIPOL1_ENST00000539062.2_Splice_Site|MIPOL1_ENST00000545536.1_Splice_Site|MIPOL1_ENST00000536774.1_Splice_Site	NM_001195296.1|NM_001195297.1|NM_138731.6	NP_001182225.1|NP_001182226.1|NP_620059.1	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1											breast(2)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	23	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		TATTTTGGTAGCTCTGGTTGA	0.358000													28	98					1.39649e-27	2.97684e-27	0.012213	1	0
NLRP7	199713	broad.mit.edu	37	19	55450278	55450278	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:55450278C>A	ENST00000588756.1	-	6	2395	c.1909G>T	c.(1909-1911)Gaa>Taa	p.E637*	NLRP7_ENST00000592784.1_Nonsense_Mutation_p.E637*|NLRP7_ENST00000590030.1_Nonsense_Mutation_p.E637*|NLRP7_ENST00000328092.5_Nonsense_Mutation_p.E637*|NLRP7_ENST00000448121.2_Nonsense_Mutation_p.E637*|NLRP7_ENST00000446217.1_Nonsense_Mutation_p.E665*|NLRP7_ENST00000340844.2_Nonsense_Mutation_p.E637*			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	637							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		ATGTCCAGTTCAAAATCCATG	0.468000													22	43					1.9806e-07	2.83538e-07	0.014323	1	0
TP63	8626	broad.mit.edu	37	3	189612219	189612219	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:189612219G>T	ENST00000264731.3	+	14	2060	c.1971G>T	c.(1969-1971)gaG>gaT	p.E657D	TP63_ENST00000354600.5_Missense_Mutation_p.E563D|TP63_ENST00000456148.1_Missense_Mutation_p.E559D|TP63_ENST00000449992.1_Missense_Mutation_p.E478D|TP63_ENST00000440651.2_Missense_Mutation_p.E653D|TP63_ENST00000320472.5_3'UTR|TP63_ENST00000382063.4_Missense_Mutation_p.E572D	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	657	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CCCGAGATGAGTGGAATGACT	0.552000										HNSCC(45;0.13)			21	70					7.45023e-12	1.26338e-11	0.010504	1	0
ITIH6	347365	broad.mit.edu	37	X	54784218	54784218	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:54784218C>T	ENST00000218436.6	-	8	2318	c.2289G>A	c.(2287-2289)gtG>gtA	p.V763V		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	763	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TGCCAGGTTTCACAGGTGGGA	0.532000													6	75					0	0	0.021553	0	0
FLG2	388698	broad.mit.edu	37	1	152325965	152325965	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:152325965G>T	ENST00000388718.5	-	3	4369	c.4297C>A	c.(4297-4299)Cac>Aac	p.H1433N	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1433							calcium ion binding|structural molecule activity	p.H1433Y(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCCCTGAGTGCACTTCACTG	0.542000													71	341					2.26907e-38	4.9613e-38	0.014410	1	0
PLD1	5337	broad.mit.edu	37	3	171426597	171426597	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:171426597C>A	ENST00000356327.5	-	11	1163	c.1093G>T	c.(1093-1095)Gtg>Ttg	p.V365L	PLD1_ENST00000342215.6_Missense_Mutation_p.V365L|PLD1_ENST00000351298.4_Missense_Mutation_p.V365L|PLD1_ENST00000340989.4_Missense_Mutation_p.V365L	NM_001130081.2	NP_001123553.1	Q13393	PLD1_HUMAN	phospholipase D1, phosphatidylcholine-specific	365					cell communication|chemotaxis|Ras protein signal transduction	endoplasmic reticulum membrane|Golgi membrane|late endosome membrane|perinuclear region of cytoplasm	NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|lung(27)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	63	all_cancers(22;4.53e-19)|Ovarian(172;0.00197)|Breast(254;0.186)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)		Choline(DB00122)	GCATTTGCCACATCTTCAAAA	0.318000													15	62					1.67942e-08	2.54344e-08	0.006122	1	0
ZFYVE28	57732	broad.mit.edu	37	4	2306941	2306941	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:2306941C>A	ENST00000290974.2	-	8	1465	c.1126G>T	c.(1126-1128)Gag>Tag	p.E376*	ZFYVE28_ENST00000515312.1_Nonsense_Mutation_p.E306*|RP11-478C1.7_ENST00000510632.1_RNA|ZFYVE28_ENST00000511071.1_Nonsense_Mutation_p.E346*	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	376					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						GGGCTGCCCTCCGCTCCTGGC	0.672000													5	45					0.00116845	0.00132867	0.021553	1	0
ASPHD2	57168	broad.mit.edu	37	22	26830260	26830260	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:26830260G>A	ENST00000215906.5	+	2	1117	c.679G>A	c.(679-681)Gag>Aag	p.E227K		NM_020437.4	NP_065170.2	Q6ICH7	ASPH2_HUMAN	aspartate beta-hydroxylase domain containing 2	227					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|prostate(4)|urinary_tract(1)	16						CCCCAGCGGGGAGTGGTTCAC	0.542000													8	86					0	0	0.004482	0	0
RRM2B	50484	broad.mit.edu	37	8	103231152	103231152	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:103231152C>A	ENST00000251810.3	-	6	817	c.574G>T	c.(574-576)Gct>Tct	p.A192S	RRM2B_ENST00000395912.2_Missense_Mutation_p.A140S|RRM2B_ENST00000519962.1_Intron|RRM2B_ENST00000519317.1_Intron	NM_001172478.1|NM_015713.4	NP_001165949.1|NP_056528.2	Q7LG56	RIR2B_HUMAN	ribonucleotide reductase M2 B (TP53 inducible)	192					deoxyribonucleoside diphosphate metabolic process|DNA repair|nucleobase, nucleoside and nucleotide interconversion	nucleoplasm	ribonucleoside-diphosphate reductase activity|transition metal ion binding			breast(1)|endometrium(1)|large_intestine(1)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	9	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000728)			CCTTCTACAGCAGCAAAGGCC	0.368000								Modulation of nucleotide pools					21	130					5.35047e-06	7.10609e-06	0.018920	1	0
PTPRT	11122	broad.mit.edu	37	20	41419856	41419856	+	Silent	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:41419856A>T	ENST00000373198.3	-	3	700	c.465T>A	c.(463-465)acT>acA	p.T155T	PTPRT_ENST00000373193.3_Silent_p.T155T|PTPRT_ENST00000373201.1_Silent_p.T155T|PTPRT_ENST00000356100.2_Silent_p.T155T|PTPRT_ENST00000373184.1_Silent_p.T155T|PTPRT_ENST00000373187.1_Silent_p.T155T|PTPRT_ENST00000373190.1_Silent_p.T155T	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	155	MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				GTGGCCAGAAAGTGCTGATGG	0.483000													7	145					0	0	0.029380	0	0
PRRC2C	23215	broad.mit.edu	37	1	171510839	171510839	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:171510839G>T	ENST00000367742.3	+	16	4476	c.4234G>T	c.(4234-4236)Gag>Tag	p.E1412*	PRRC2C_ENST00000338920.4_Nonsense_Mutation_p.E1410*|PRRC2C_ENST00000392078.3_Nonsense_Mutation_p.E1412*|PRRC2C_ENST00000426496.2_Nonsense_Mutation_p.E1410*			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	1410	Arg-rich.						protein C-terminus binding										TCCAAAATTTGAGCGAAAATT	0.493000													7	26					1.12685e-05	1.46233e-05	0.004482	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84651157	84651157	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:84651157C>A	ENST00000286744.5	+	21	3001	c.2777C>A	c.(2776-2778)cCc>cAc	p.P926H	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.P926H	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	926	Ig-like C2-type 1.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			TATTTGCTGCCCAACACATCC	0.517000													12	86					7.03913e-09	1.0805e-08	0.013537	1	0
BAI1	575	broad.mit.edu	37	8	143561100	143561100	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:143561100G>A	ENST00000517894.1	+	9	2667	c.1773G>A	c.(1771-1773)tgG>tgA	p.W591*	BAI1_ENST00000323289.5_Nonsense_Mutation_p.W591*			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	591					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CTGTGATCTGGAAGGAGACCC	0.642000													12	76					0	0	0.020292	0	0
OR2H1	26716	broad.mit.edu	37	6	29429716	29429716	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:29429716T>C	ENST00000377136.1	+	4	635	c.170T>C	c.(169-171)aTg>aCg	p.M57T	OR2H1_ENST00000377132.1_Missense_Mutation_p.M57T|OR2H1_ENST00000473369.1_Intron|OR2H1_ENST00000377133.1_Missense_Mutation_p.M57T|OR2H1_ENST00000396792.2_Missense_Mutation_p.M57T|OR2H1_ENST00000442615.1_Missense_Mutation_p.M57T			Q9GZK4	OR2H1_HUMAN	olfactory receptor, family 2, subfamily H, member 1	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(5)|lung(12)	17						CACTCTCCAATGTACTTTTTC	0.517000													28	75					0	0	0.030593	0	0
LAMA2	3908	broad.mit.edu	37	6	129748969	129748969	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:129748969G>A	ENST00000421865.2	+	41	5987	c.5938G>A	c.(5938-5940)Gaa>Aaa	p.E1980K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1980	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GATTCTTAACGAAGCCAAGAA	0.383000													8	96					0	0	0.003080	0	0
OR2H2	7932	broad.mit.edu	37	6	29556084	29556084	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:29556084C>T	ENST00000383640.2	+	1	402	c.363C>T	c.(361-363)taC>taT	p.Y121Y	GABBR1_ENST00000355973.3_Intron	NM_007160.3	NP_009091.3	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H, member 2	121					defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	14						TTGATCGCTACGTGGCTGTCT	0.577000													8	89					0	0	0.006214	0	0
KCNN2	3781	broad.mit.edu	37	5	113831760	113831760	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:113831760G>T	ENST00000512097.3	+	9	2639	c.1621G>T	c.(1621-1623)Gag>Tag	p.E541*	KCNN2_ENST00000503706.1_Nonsense_Mutation_p.E193*|KCNN2_ENST00000264773.3_Nonsense_Mutation_p.E541*|RP11-492A10.1_ENST00000514115.1_RNA			Q9H2S1	KCNN2_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	541						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		AGATTTCATTGAGGCTCAGAT	0.552000													38	77					3.33393e-15	6.19419e-15	0.021022	1	0
FCRL5	83416	broad.mit.edu	37	1	157497526	157497526	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:157497526G>T	ENST00000361835.3	-	9	1998	c.1841C>A	c.(1840-1842)tCt>tAt	p.S614Y	FCRL5_ENST00000368191.3_Missense_Mutation_p.S529Y|FCRL5_ENST00000368190.3_Missense_Mutation_p.S614Y|FCRL5_ENST00000356953.4_Missense_Mutation_p.S614Y	NM_001195388.1|NM_031281.2	NP_001182317.1|NP_112571.2	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	614	Ig-like C2-type 6.					integral to membrane|plasma membrane	receptor activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(45)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	85	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TTCTCCTCCAGAGGGGGCTGA	0.552000													30	103					3.99451e-17	7.71666e-17	0.009535	1	0
EP400	57634	broad.mit.edu	37	12	132466659	132466659	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:132466659A>T	ENST00000333577.4	+	6	1782	c.1673A>T	c.(1672-1674)cAg>cTg	p.Q558L	EP400_ENST00000389561.2_Missense_Mutation_p.Q522L|EP400_ENST00000389562.2_Missense_Mutation_p.Q521L|EP400_ENST00000332482.4_Missense_Mutation_p.Q485L|EP400_ENST00000330386.6_Missense_Mutation_p.Q522L			Q96L91	EP400_HUMAN	E1A binding protein p400	558					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CCCACGCCGCAGGCCGCGCAG	0.602000													33	184					0	0	0.017118	0	0
SLC12A1	6557	broad.mit.edu	37	15	48577447	48577447	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:48577447G>T	ENST00000396577.3	+	21	2844		c.e21+1		SLC12A1_ENST00000558405.1_Splice_Site|SLC12A1_ENST00000380993.3_Splice_Site	NM_001184832.1	NP_001171761.1	Q13621	S12A1_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 1						potassium ion transport|sodium ion transport	integral to membrane|membrane fraction	sodium:potassium:chloride symporter activity	p.?(2)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(30)|ovary(1)|prostate(2)|skin(1)	59		all_lung(180;0.00219)		all cancers(107;1.76e-09)|GBM - Glioblastoma multiforme(94;1.48e-06)	Bumetanide(DB00887)|Chlormerodrin(DB00534)|Chlorthalidone(DB00310)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Metolazone(DB00524)|Potassium Chloride(DB00761)|Torasemide(DB00214)|Trichlormethiazide(DB01021)	CCTAAAAAAGGTAAGAACTTT	0.368000													19	51					4.96729e-08	7.32702e-08	0.008871	1	0
ELAVL4	1996	broad.mit.edu	37	1	50610738	50610738	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:50610738C>A	ENST00000371824.1	+	2	376	c.119C>A	c.(118-120)aCc>aAc	p.T40N	ELAVL4_ENST00000371821.1_Missense_Mutation_p.T45N|ELAVL4_ENST00000357083.4_Missense_Mutation_p.T57N|ELAVL4_ENST00000371819.1_Missense_Mutation_p.T45N|ELAVL4_ENST00000492299.1_3'UTR|ELAVL4_ENST00000371827.1_Missense_Mutation_p.T40N|ELAVL4_ENST00000371823.4_Missense_Mutation_p.T40N|ELAVL4_ENST00000448907.2_Missense_Mutation_p.T43N			P26378	ELAV4_HUMAN	ELAV like neuron-specific RNA binding protein 4	40					mRNA processing		AU-rich element binding|mRNA 3'-UTR binding|nucleotide binding			NS(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	32						ACAGGGGCAACCACAGATGAC	0.473000													13	63					0.000219431	0.000257709	0.020292	1	0
DNAH5	1767	broad.mit.edu	37	5	13823411	13823411	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:13823411C>A	ENST00000265104.4	-	40	6752	c.6648G>T	c.(6646-6648)aaG>aaT	p.K2216N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2216					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGTAACCTGCCTTGTCCAGAA	0.388000									Kartagener syndrome				122	115					2.51472e-61	5.55199e-61	0.014410	1	0
RBMXL1	494115	broad.mit.edu	37	1	89448560	89448560	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:89448560C>G	ENST00000399794.2	-	3	1665	c.950G>C	c.(949-951)cGt>cCt	p.R317P	CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000260508.4_Intron|CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000370485.2_Intron|RBMXL1_ENST00000321792.5_Missense_Mutation_p.R317P	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	317	Ser-rich.						nucleotide binding|RNA binding										ATATCCATCACGTGAGCTGCT	0.498000													58	238					0	0	0.014410	0	0
DOCK8	81704	broad.mit.edu	37	9	328021	328021	+	Splice_Site	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:328021G>C	ENST00000432829.2	+	9	1006		c.e9-1		DOCK8_ENST00000469391.1_Splice_Site|DOCK8_ENST00000453981.1_Splice_Site	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8						blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CTCATTTACAGATCTCAGAAA	0.408000													21	46					0	0	0.012319	0	0
TCP10L2	401285	broad.mit.edu	37	6	167591903	167591903	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:167591903C>G	ENST00000366832.2	+	5	661	c.530C>G	c.(529-531)tCg>tGg	p.S177W		NM_001145121.1	NP_001138593.1	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	177										endometrium(1)|kidney(2)|lung(3)	6						AGAATTAACTCGGGGAAAACA	0.433000													6	45					0	0	0.004482	0	0
RNF38	152006	broad.mit.edu	37	9	36369894	36369894	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:36369894C>T	ENST00000357058.3	-	4	749	c.143G>A	c.(142-144)cGt>cAt	p.R48H	RNF38_ENST00000377877.4_Missense_Mutation_p.R55H|RNF38_ENST00000350199.4_Missense_Mutation_p.R48H|RNF38_ENST00000353739.4_Missense_Mutation_p.R81H|RNF38_ENST00000377885.2_Missense_Mutation_p.R48H|RNF38_ENST00000259605.6_Missense_Mutation_p.R131H|RNF38_ENST00000491349.1_5'UTR	NM_194328.2	NP_919309.1	Q9H0F5	RNF38_HUMAN	ring finger protein 38	131							zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			TCGAGACAGACGATCCCTTCT	0.453000													6	27					0	0	0.021553	0	0
CADPS	8618	broad.mit.edu	37	3	62636563	62636563	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:62636563G>T	ENST00000383710.4	-	5	1511	c.1162C>A	c.(1162-1164)Cag>Aag	p.Q388K	CADPS_ENST00000283269.9_Missense_Mutation_p.Q388K|CADPS_ENST00000490353.2_Missense_Mutation_p.Q388K|CADPS_ENST00000357948.3_Missense_Mutation_p.Q388K	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	388					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TTGGAGAGCTGGTTCTCACTC	0.517000													8	52					1.76689e-08	2.65229e-08	0.006214	1	0
STAB2	55576	broad.mit.edu	37	12	104056673	104056673	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:104056673C>A	ENST00000388887.2	+	18	2123	c.1919C>A	c.(1918-1920)gCc>gAc	p.A640D		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	640	FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GAGATCACTGCCAAAAATGGC	0.423000													20	92					1.55795e-14	2.84786e-14	0.012319	1	0
CIITA	4261	broad.mit.edu	37	16	10997612	10997612	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:10997612T>C	ENST00000324288.8	+	9	930	c.797T>C	c.(796-798)gTa>gCa	p.V266A	CIITA_ENST00000537380.1_3'UTR|CIITA_ENST00000381835.5_Missense_Mutation_p.V217A	NM_000246.3	NP_000237.2	P33076	C2TA_HUMAN	class II, major histocompatibility complex, transactivator	266					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)|large_intestine(7)|ovary(1)|skin(1)|stomach(2)	12						GCCAGCCAAGTACCCCCTCCC	0.602000			T	"""FLJ27352, CD274, CD273, RALGDS, RUNDC2A, C16orf75, BCL6"""	"""PMBL, Hodgkin Lymphona, """								9	117					0	0	0.004482	0	0
OR10K2	391107	broad.mit.edu	37	1	158390349	158390349	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:158390349G>T	ENST00000314902.2	-	1	307	c.308C>A	c.(307-309)tCc>tAc	p.S103Y		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					GAAGAGGAAGGAAAACATTTG	0.483000													32	125					1.45844e-13	2.57594e-13	0.013726	1	0
GTF2IRD1	9569	broad.mit.edu	37	7	73927187	73927187	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:73927187G>T	ENST00000476977.1	+	3	1842	c.151G>T	c.(151-153)Gag>Tag	p.E51*	GTF2IRD1_ENST00000489094.1_3'UTR|GTF2IRD1_ENST00000455841.2_Nonsense_Mutation_p.E51*|GTF2IRD1_ENST00000424337.2_Nonsense_Mutation_p.E51*|GTF2IRD1_ENST00000265755.3_Nonsense_Mutation_p.E51*			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	51						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						ACTGAACGCCGAGGTGGCCTG	0.597000													7	44					8.12818e-05	9.85234e-05	0.029380	1	0
SLC10A2	6555	broad.mit.edu	37	13	103705019	103705019	+	Missense_Mutation	SNP	C	C	A	rs143232105		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr13:103705019C>A	ENST00000245312.3	-	3	1132	c.536G>T	c.(535-537)gGa>gTa	p.G179V		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	179					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					AACAAACATTCCAATGGAAAC	0.388000													14	48					1.36491e-13	2.43606e-13	0.016723	1	0
CST6	1474	broad.mit.edu	37	11	65780862	65780862	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:65780862G>T	ENST00000312134.2	+	3	645	c.441G>T	c.(439-441)gtG>gtT	p.V147V		NM_001323.3	NP_001314.1	Q15828	CYTM_HUMAN	cystatin E/M	147					anatomical structure morphogenesis	extracellular region	cysteine-type endopeptidase inhibitor activity			large_intestine(1)|lung(1)|ovary(1)	3						ACAACTGTGTGCAGATGTGAT	0.562000													29	61					1.75199e-13	3.07842e-13	0.034045	1	0
OTOA	146183	broad.mit.edu	37	16	21698784	21698784	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:21698784G>T	ENST00000388958.3	+	7	451	c.450G>T	c.(448-450)ttG>ttT	p.L150F	OTOA_ENST00000388956.4_Missense_Mutation_p.L71F|OTOA_ENST00000286149.4_Missense_Mutation_p.L150F	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	150					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix				breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		AACGAGCCTTGCAGAGCCCTG	0.522000													23	103					2.12542e-12	3.66823e-12	0.030593	1	0
CMTR2	55783	broad.mit.edu	37	16	71319360	71319360	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:71319360T>A	ENST00000338099.5	-	3	800	c.464A>T	c.(463-465)aAc>aTc	p.N155I	FTSJD1_ENST00000434935.2_Missense_Mutation_p.N155I			Q8IYT2	FTSJ1_HUMAN		155						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TAAGTAGTGGTTGAGACTAGC	0.413000													27	72					0	0	0.030593	0	0
CAPN15	6650	broad.mit.edu	37	16	597502	597502	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:597502G>T	ENST00000219611.2	+	4	1027	c.664G>T	c.(664-666)Gcc>Tcc	p.A222S	LA16c-366D1.3_ENST00000565879.1_RNA	NM_005632.2	NP_005623.1			calpain 15																		GGGCCCAGCTGCCGAACCAGA	0.751000													6	33					0.00307968	0.00343872	0.003080	1	0
CNTNAP2	26047	broad.mit.edu	37	7	146741074	146741074	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:146741074C>A	ENST00000361727.3	+	4	994	c.478C>A	c.(478-480)Cgc>Agc	p.R160S		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	160	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding	p.R160C(1)		NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CCGCTATGTGCGCATAGTGCC	0.428000										HNSCC(39;0.1)			32	105					2.81731e-10	4.55053e-10	0.010818	1	0
CACNA1C	775	broad.mit.edu	37	12	2763057	2763057	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:2763057C>A	ENST00000399655.1	+	33	4396	c.4131C>A	c.(4129-4131)atC>atA	p.I1377I	CACNA1C_ENST00000399644.1_Silent_p.I1377I|CACNA1C_ENST00000399637.1_Silent_p.I1377I|CACNA1C_ENST00000399601.1_Silent_p.I1377I|CACNA1C_ENST00000399638.1_Silent_p.I1405I|CACNA1C_ENST00000344100.3_Silent_p.I1399I|CACNA1C_ENST00000399629.1_Silent_p.I1394I|CACNA1C_ENST00000327702.7_Silent_p.I1377I|CACNA1C_ENST00000406454.3_Silent_p.I1377I|CACNA1C_ENST00000399641.1_Silent_p.I1377I|CACNA1C_ENST00000399595.1_Silent_p.I1366I|CACNA1C_ENST00000399591.1_Silent_p.I1366I|CACNA1C_ENST00000335762.5_Silent_p.I1402I|CACNA1C_ENST00000399606.1_Silent_p.I1397I|CACNA1C_ENST00000402845.3_Silent_p.I1377I|CACNA1C_ENST00000399649.1_Silent_p.I1364I|CACNA1C_ENST00000347598.4_Silent_p.I1425I|CACNA1C_ENST00000399621.1_Silent_p.I1377I|CACNA1C_ENST00000399597.1_Silent_p.I1377I|CACNA1C_ENST00000399617.1_Silent_p.I1377I|CACNA1C_ENST00000399603.1_Silent_p.I1377I|CACNA1C_ENST00000399634.1_Silent_p.I1377I	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1425					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ACGCGGTGATCGGGATGCAGG	0.627000													6	23					8.12818e-05	9.85234e-05	0.029380	1	0
APOA5	116519	broad.mit.edu	37	11	116661395	116661395	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:116661395T>G	ENST00000542499.1	-	4	622	c.550A>C	c.(550-552)Acc>Ccc	p.T184P	APOA5_ENST00000227665.4_Missense_Mutation_p.T184P	NM_001166598.1|NM_052968.4	NP_001160070.1|NP_443200.2	Q6Q788	APOA5_HUMAN	apolipoprotein A-V	184					acylglycerol homeostasis|cholesterol homeostasis|lipid transport|lipoprotein metabolic process|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor-mediated endocytosis|positive regulation of triglyceride catabolic process|positive regulation of very-low-density lipoprotein particle remodeling|tissue regeneration|triglyceride catabolic process|triglyceride homeostasis	chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	enzyme binding|heparin binding|lipoprotein lipase activator activity|low-density lipoprotein particle receptor binding|phosphatidylcholine binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(8)|urinary_tract(1)	14	all_hematologic(175;0.0487)	all_cancers(61;3.31e-09)|all_epithelial(67;8.03e-06)|Breast(348;0.0126)|Melanoma(852;0.0153)|Acute lymphoblastic leukemia(157;0.0257)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0433)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;4.93e-06)|all cancers(92;0.000123)|OV - Ovarian serous cystadenocarcinoma(223;0.149)		AAGCGGCCGGTGTGGTGCACC	0.682000													10	37					0	0	0.006214	0	0
PYGB	5834	broad.mit.edu	37	20	25239872	25239872	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:25239872G>T	ENST00000216962.4	+	2	353		c.e2-1			NM_002862.3	NP_002853.2	P11216	PYGB_HUMAN	phosphorylase, glycogen; brain						glucose metabolic process|glycogen catabolic process	cytoplasm	glycogen phosphorylase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	31					Pyridoxal Phosphate(DB00114)	TGCTTCCTCAGCGCATTTATT	0.478000													12	55					0.0135373	0.0146816	0.013537	1	0
ABCA4	24	broad.mit.edu	37	1	94473843	94473843	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:94473843C>A	ENST00000370225.3	-	42	5932	c.5846G>T	c.(5845-5847)gGc>gTc	p.G1949V	ABCA4_ENST00000535881.1_Missense_Mutation_p.G68V|ABCA4_ENST00000536513.1_Missense_Mutation_p.G219V|ABCA4_ENST00000465352.1_5'UTR	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	1949	ABC transporter 2.				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		GCTGGAGGTGCCTGGATAAAT	0.542000													12	39					5.50884e-06	7.2738e-06	0.013537	1	0
TMEM63B	55362	broad.mit.edu	37	6	44122119	44122119	+	Silent	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:44122119A>T	ENST00000259746.9	+	23	2427	c.2244A>T	c.(2242-2244)acA>acT	p.T748T	TMEM63B_ENST00000323267.6_Silent_p.T748T			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	748						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			ACACGGAGACAGATACTGTGG	0.622000													18	66					0	0	0.033300	0	0
C12orf66	144577	broad.mit.edu	37	12	64588160	64588160	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:64588160G>C	ENST00000311915.8	-	3	827	c.800C>G	c.(799-801)gCc>gGc	p.A267G	C12orf66_ENST00000544871.1_Missense_Mutation_p.A214G|C12orf66_ENST00000398055.3_Missense_Mutation_p.A267G			Q96MD2	CL066_HUMAN	chromosome 12 open reading frame 66	267										central_nervous_system(1)|large_intestine(1)|lung(2)|ovary(1)	5						GCTAAACTTGGCAAGAAGCAT	0.458000													19	78					0	0	0.010504	0	0
MYH3	4621	broad.mit.edu	37	17	10543408	10543408	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:10543408C>T	ENST00000583535.1	-	22	2674	c.2587G>A	c.(2587-2589)Gaa>Aaa	p.E863K	MYH3_ENST00000226209.7_Missense_Mutation_p.E863K	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	863					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TTGGCGAGTTCATCTTTGGTT	0.478000													22	68					0	0	0.014323	0	0
FUNDC2P2	388965	broad.mit.edu	37	2	84518123	84518123	+	RNA	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:84518123T>A	ENST00000331369.5	+	0	317																											GTGCACGGGTTTTATATTCCA	0.488000													27	155					0	0	0.030593	0	0
RECK	8434	broad.mit.edu	37	9	36118894	36118894	+	Silent	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:36118894C>G	ENST00000377966.3	+	18	2960	c.2394C>G	c.(2392-2394)tcC>tcG	p.S798S		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	798						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			AGCACAGCTCCGTCGCCGAGT	0.607000													6	45					0	0	0.021553	0	0
FCRL3	115352	broad.mit.edu	37	1	157665243	157665243	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:157665243G>T	ENST00000368184.3	-	8	1578	c.1287C>A	c.(1285-1287)gcC>gcA	p.A429A	FCRL3_ENST00000473231.1_5'UTR|FCRL3_ENST00000368186.5_Silent_p.A429A|RP11-367J7.3_ENST00000453692.1_RNA	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	429	Ig-like C2-type 5.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					CTCCAGAGGGGGCTGAGCTGT	0.577000													28	134					3.73808e-20	7.49822e-20	0.027356	1	0
FBXO40	51725	broad.mit.edu	37	3	121341065	121341065	+	Silent	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:121341065T>C	ENST00000338040.4	+	3	1203	c.789T>C	c.(787-789)gcT>gcC	p.A263A		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	263					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		GAGAGGGCGCTCCCAAAAAGA	0.483000													10	34					0	0	0.006214	0	0
SLC17A4	10050	broad.mit.edu	37	6	25779404	25779404	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:25779404C>A	ENST00000377905.4	+	12	1601	c.1482C>A	c.(1480-1482)ttC>ttA	p.F494L	SLC17A4_ENST00000439485.2_Missense_Mutation_p.F264L|SLC17A4_ENST00000397076.2_3'UTR	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	494					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						AGCAGACATTCACCCACCTCT	0.473000													18	98					1.2644e-06	1.74048e-06	0.010504	1	0
TINF2	26277	broad.mit.edu	37	14	24709508	24709508	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:24709508G>A	ENST00000267415.7	-	7	1431	c.1090C>T	c.(1090-1092)Ctg>Ttg	p.L364L	TINF2_ENST00000538777.1_3'UTR|TINF2_ENST00000558566.1_3'UTR|TINF2_ENST00000399423.4_3'UTR|TINF2_ENST00000540705.1_Silent_p.L329L	NM_001099274.1	NP_001092744.1	Q9BSI4	TINF2_HUMAN	TERF1 (TRF1)-interacting nuclear factor 2	364					negative regulation of epithelial cell proliferation|negative regulation of protein ADP-ribosylation|negative regulation of telomere maintenance via telomerase|positive regulation of telomere maintenance|protein localization to chromosome, telomeric region|telomere assembly|telomere maintenance via telomere lengthening	nuclear telomere cap complex|nucleoplasm|perinucleolar chromocenter	protein binding|telomeric DNA binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|prostate(1)|urinary_tract(1)	7				GBM - Glioblastoma multiforme(265;0.0185)		GATAGTCTCAGGGGGTCCATG	0.502000									Congenital Dyskeratosis;Ataxia Pancytopenia syndrome				6	67					0	0	0.029380	0	0
PORCN	64840	broad.mit.edu	37	X	48369726	48369726	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:48369726G>A	ENST00000359882.4	+	3	359	c.180G>A	c.(178-180)ggG>ggA	p.G60G	PORCN_ENST00000361988.3_Silent_p.G60G|PORCN_ENST00000355961.4_Silent_p.G60G|PORCN_ENST00000537758.1_Silent_p.G60G|PORCN_ENST00000326194.6_Silent_p.G60G|PORCN_ENST00000355092.3_Silent_p.G60G|PORCN_ENST00000486272.1_3'UTR|PORCN_ENST00000367574.4_Intron			Q9H237	PORCN_HUMAN	porcupine homolog (Drosophila)	60	Leu-rich.		G -> R (in FODH).		Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGGCAGGCGGGTTCTTCAGCC	0.552000											OREG0019764	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	98					0	0	0.006122	0	0
PRLR	5618	broad.mit.edu	37	5	35066176	35066176	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:35066176G>T	ENST00000382002.5	-	10	1310	c.884C>A	c.(883-885)gCc>gAc	p.A295D	PRLR_ENST00000513753.1_Intron|PRLR_ENST00000511486.1_Missense_Mutation_p.A194D|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000310101.5_Missense_Mutation_p.A295D|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000342362.5_Missense_Mutation_p.A194D|PRLR_ENST00000231423.3_Missense_Mutation_p.A295D|PRLR_ENST00000348262.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	295					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GCATCCCAAGGCACTCAGTAG	0.438000													6	71					2.0095e-06	2.71123e-06	0.029380	1	0
CACNA1C	775	broad.mit.edu	37	12	2742805	2742805	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:2742805G>T	ENST00000406454.3	+	30	3839	c.3839G>T	c.(3838-3840)aGt>aTt	p.S1280I	CACNA1C_ENST00000399644.1_Missense_Mutation_p.S1280I|CACNA1C_ENST00000399637.1_Intron|CACNA1C_ENST00000399601.1_Intron|CACNA1C_ENST00000399638.1_Missense_Mutation_p.S1280I|CACNA1C_ENST00000399655.1_Intron|CACNA1C_ENST00000344100.3_Intron|CACNA1C_ENST00000399629.1_Missense_Mutation_p.S1280I|CACNA1C_ENST00000327702.7_Intron|CACNA1C_ENST00000399641.1_Intron|CACNA1C_ENST00000399595.1_Intron|CACNA1C_ENST00000399591.1_Intron|CACNA1C_ENST00000335762.5_Intron|CACNA1C_ENST00000399606.1_Intron|CACNA1C_ENST00000402845.3_Missense_Mutation_p.S1280I|CACNA1C_ENST00000399649.1_Intron|CACNA1C_ENST00000347598.4_Missense_Mutation_p.S1300I|CACNA1C_ENST00000399621.1_Intron|CACNA1C_ENST00000399597.1_Missense_Mutation_p.S1280I|CACNA1C_ENST00000399617.1_Missense_Mutation_p.S1280I|CACNA1C_ENST00000399603.1_Missense_Mutation_p.S1280I|CACNA1C_ENST00000399634.1_Intron			Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1300					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGTTACTTTAGTGATCCCTGG	0.443000													9	65					0.00448238	0.00494808	0.004482	1	0
BMP6	654	broad.mit.edu	37	6	7862687	7862687	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:7862687G>C	ENST00000283147.6	+	4	1319	c.1160G>C	c.(1159-1161)cGc>cCc	p.R387P		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	387					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					AGTCGTAATCGCTCTACCCAG	0.592000													4	69					0	0	0.014758	0	0
VCAN	1462	broad.mit.edu	37	5	82834365	82834365	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:82834365C>G	ENST00000265077.3	+	8	6108	c.5543C>G	c.(5542-5544)aCt>aGt	p.T1848S	VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000512590.2_Intron|VCAN_ENST00000343200.5_Missense_Mutation_p.T861S|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000513016.1_3'UTR	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1848	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		GAAACCACCACTGTTTCTTCA	0.507000													40	129					0	0	0.030466	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846149	47846149	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:47846149G>T	ENST00000339488.4	-	3	2464	c.2431C>A	c.(2431-2433)Ccc>Acc	p.P811T		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	811						integral to membrane	hedgehog receptor activity										TTGGAAGGGGGGAAAAACGTT	0.448000													18	90					3.41278e-10	5.47333e-10	0.033300	1	0
SV2C	22987	broad.mit.edu	37	5	75427578	75427578	+	Translation_Start_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:75427578G>T	ENST00000502798.2	+	2	445	c.3G>T	c.(1-3)atG>atT	p.M1I	SV2C_ENST00000322285.7_Start_Codon_SNP_p.M1I	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	1	Interaction with SYT1 (By similarity).				neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		GAGATAAGATGGAAGACTCTT	0.443000													8	25					5.4927e-09	8.50806e-09	0.004482	1	0
DRD5	1816	broad.mit.edu	37	4	9784743	9784743	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:9784743G>T	ENST00000304374.2	+	1	1486	c.1090G>T	c.(1090-1092)Gac>Tac	p.D364Y		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	364					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	CTTCAACGCCGACTTTCAGAA	0.592000													16	50					1.15088e-07	1.65804e-07	0.028581	1	0
COLGALT2	23127	broad.mit.edu	37	1	183933123	183933123	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:183933123G>T	ENST00000361927.4	-	6	1235	c.864C>A	c.(862-864)caC>caA	p.H288Q	COLGALT2_ENST00000367520.3_Missense_Mutation_p.H25Q|COLGALT2_ENST00000546159.1_Missense_Mutation_p.H288Q	NM_015101.2	NP_055916.1			collagen beta(1-O)galactosyltransferase 2																		GGTAGCCATAGTGCTCTCTGT	0.512000													9	38					3.09899e-07	4.3811e-07	0.004482	1	0
CEP192	55125	broad.mit.edu	37	18	13048964	13048964	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr18:13048964C>T	ENST00000506447.1	+	16	2254	c.2174C>T	c.(2173-2175)gCa>gTa	p.A725V	CEP192_ENST00000430049.2_Missense_Mutation_p.A250V|CEP192_ENST00000325971.8_Missense_Mutation_p.A129V	NM_032142.3	NP_115518.3	B7ZMF0	B7ZMF0_HUMAN	centrosomal protein 192kDa	320										NS(1)|breast(4)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(36)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71						ATTGCAGAGGCATCAGTTAAT	0.413000													10	108					0	0	0.006214	0	0
COPS7A	50813	broad.mit.edu	37	12	6839882	6839882	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:6839882C>T	ENST00000543155.1	+	7	1166	c.684C>T	c.(682-684)gcC>gcT	p.A228A	COPS7A_ENST00000539735.1_Silent_p.A228A|COPS7A_ENST00000538410.1_Intron|COPS7A_ENST00000229251.3_Silent_p.A228A|COPS7A_ENST00000534877.1_Silent_p.A228A|COPS7A_ENST00000534947.1_Silent_p.A228A|COPS7A_ENST00000542150.1_3'UTR	NM_001164094.1	NP_001157566.1	Q9UBW8	CSN7A_HUMAN	COP9 signalosome subunit 7A	228					cullin deneddylation	cytoplasm|signalosome				endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|urinary_tract(1)	10						CAGCAGCAGCCGCAGCCACAT	0.547000													10	35					0	0	0.008291	0	0
NOS1	4842	broad.mit.edu	37	12	117662919	117662919	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:117662919C>A	ENST00000317775.6	-	25	4413	c.3728G>T	c.(3727-3729)cGg>cTg	p.R1243L	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.R1277L	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1243					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TTGGGGGTTCCGGGGCAGGTG	0.542000													17	97					5.3912e-06	7.14624e-06	0.006122	1	0
KRTAP9-3	83900	broad.mit.edu	37	17	39388893	39388893	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:39388893G>C	ENST00000411528.2	+	1	179	c.140G>C	c.(139-141)tGc>tCc	p.C47S		NM_031962.2	NP_114168.1	Q9BYQ3	KRA93_HUMAN	keratin associated protein 9-3	47	16 X 5 AA repeats of C-C-[RQVSHE]-[SPTN]- [TASPI].					keratin filament	protein binding			breast(1)|endometrium(3)|lung(2)|ovary(1)|prostate(1)	8		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CAGCCTTGCTGCCACCCAACT	0.622000													28	44					0	0	0.009535	0	0
GTPBP2	54676	broad.mit.edu	37	6	43589437	43589437	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:43589437G>T	ENST00000307126.5	-	12	1722	c.1723C>A	c.(1723-1725)Cgg>Agg	p.R575R	GTPBP2_ENST00000307114.7_Silent_p.R487R|GTPBP2_ENST00000476510.1_5'UTR	NM_019096.3	NP_061969.3	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	575							GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			ACACCCTCCCGGAACAGCAGT	0.572000													10	58					0.010729	0.0116545	0.010729	1	0
RP11-24M17.5	0	broad.mit.edu	37	15	76075256	76075256	+	RNA	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:76075256G>T	ENST00000395215.3	+	0	896																											GGAGAGTTTGGAGGGAAAGCT	0.577000													12	46					2.61681e-11	4.32952e-11	0.020292	1	0
FMN2	56776	broad.mit.edu	37	1	240256625	240256625	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:240256625C>G	ENST00000319653.9	+	1	1446	c.1216C>G	c.(1216-1218)Cgc>Ggc	p.R406G		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	406					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCTAGCCAGCGCTGTTTCAA	0.692000													13	56					0	0	0.016723	0	0
COBL	23242	broad.mit.edu	37	7	51095655	51095655	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:51095655G>A	ENST00000395542.2	-	12	3568	c.3384C>T	c.(3382-3384)caC>caT	p.H1128H	COBL_ENST00000265136.7_Silent_p.H1046H			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1046	WH2 1.									NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					AAGGCTCGCCGTGGCCTGGGG	0.587000													12	51					0	0	0.010729	0	0
PHKA1	5255	broad.mit.edu	37	X	71856210	71856210	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:71856210C>A	ENST00000373545.3	-	15	1924	c.1486G>T	c.(1486-1488)Gga>Tga	p.G496*	PHKA1_ENST00000541944.1_Nonsense_Mutation_p.G496*|PHKA1_ENST00000339490.3_Nonsense_Mutation_p.G496*|PHKA1_ENST00000373539.3_Nonsense_Mutation_p.G496*|PHKA1_ENST00000373542.4_Nonsense_Mutation_p.G496*			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	496					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					TAGGGTCGTCCACTGAGTTTC	0.358000													13	70					3.27435e-08	4.86148e-08	0.020292	1	0
LDB2	9079	broad.mit.edu	37	4	16587550	16587550	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:16587550G>T	ENST00000502640.1	-	5	758	c.610C>A	c.(610-612)Ctc>Atc	p.L204I	LDB2_ENST00000503178.2_Missense_Mutation_p.L80I|LDB2_ENST00000515064.1_Missense_Mutation_p.L204I|LDB2_ENST00000441778.2_Missense_Mutation_p.L204I|LDB2_ENST00000304523.5_Missense_Mutation_p.L204I			O43679	LDB2_HUMAN	LIM domain binding 2	204							LIM domain binding|transcription cofactor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						CTTACCCTGAGGTAGTTGAGG	0.408000													13	67					2.68362e-12	4.60824e-12	0.013537	1	0
CASQ1	844	broad.mit.edu	37	1	160162662	160162662	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:160162662T>A	ENST00000368079.3	+	2	607	c.332T>A	c.(331-333)gTg>gAg	p.V111E	CASQ1_ENST00000368078.3_Missense_Mutation_p.V117E	NM_001231.4	NP_001222.3	P31415	CASQ1_HUMAN	calsequestrin 1 (fast-twitch, skeletal muscle)	117						mitochondrial matrix|sarcoplasmic reticulum lumen|smooth endoplasmic reticulum	calcium ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|skin(1)	21	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GATGCAGCTGTGGCCAAGAAA	0.552000											OREG0013927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	92					0	0	0.018920	0	0
C16orf82	162083	broad.mit.edu	37	16	27078574	27078574	+	RNA	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:27078574C>G	ENST00000505035.1	+	0	547				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			GCCATGCCAGCCTGAGCAGCG	0.642000													7	19					0	0	0.029380	0	0
DRD5	1816	broad.mit.edu	37	4	9784157	9784157	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:9784157C>A	ENST00000304374.2	+	1	900	c.504C>A	c.(502-504)tcC>tcA	p.S168S		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	168					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	GGACCTTGTCCATCCTCATCT	0.632000													4	37					1.23904e-05	1.58971e-05	0.014758	1	0
OR4A15	81328	broad.mit.edu	37	11	55135827	55135827	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:55135827G>T	ENST00000314706.3	+	1	468	c.468G>T	c.(466-468)aaG>aaT	p.K156N		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	156					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						CCATCTGTAAGCCTCTTCATG	0.433000													73	134					2.23852e-25	4.68368e-25	0.014410	1	0
TFAP2D	83741	broad.mit.edu	37	6	50696992	50696992	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:50696992G>C	ENST00000008391.3	+	5	1078	c.850G>C	c.(850-852)Gct>Cct	p.A284P	TFAP2D_ENST00000492804.1_3'UTR	NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	284	H-S-H (helix-span-helix), dimerization.						DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					ACGGAAAGCAGCTAATGTCAC	0.428000													6	152					0	0	0.029380	0	0
ZNF334	55713	broad.mit.edu	37	20	45130201	45130201	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:45130201T>C	ENST00000457685.2	-	6	2986	c.1663A>G	c.(1663-1665)Act>Gct	p.T555A	ZNF334_ENST00000347606.4_Missense_Mutation_p.T593A|ZNF334_ENST00000593880.1_Missense_Mutation_p.T616A			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	593					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				CCAGTGTGAGTTCGCTGATGT	0.438000													32	133					0	0	0.010818	0	0
ELOVL6	79071	broad.mit.edu	37	4	110980902	110980902	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:110980902C>T	ENST00000394607.3	-	4	393	c.230G>A	c.(229-231)gGt>gAt	p.G77D	ELOVL6_ENST00000506461.1_5'UTR|ELOVL6_ENST00000302274.3_Missense_Mutation_p.G77D			Q9H5J4	ELOV6_HUMAN	ELOVL fatty acid elongase 6	77					fatty acid elongation, saturated fatty acid|long-chain fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process		fatty acid elongase activity|protein binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	8				OV - Ovarian serous cystadenocarcinoma(123;0.00462)		TCGAAGAGCACCGAATATACT	0.403000													6	22					0	0	0.021553	0	0
FAM46D	169966	broad.mit.edu	37	X	79698805	79698805	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:79698805A>G	ENST00000538312.1	+	5	1101	c.767A>G	c.(766-768)aAa>aGa	p.K256R	FAM46D_ENST00000308293.5_Missense_Mutation_p.K256R	NM_001170574.1	NP_001164045.1	Q8NEK8	FA46D_HUMAN	family with sequence similarity 46, member D	256										kidney(1)|large_intestine(6)|liver(3)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23						TCAGAAATCAAAAACCTAGAA	0.388000													4	49					0	0	0.009096	0	0
ABCG8	64241	broad.mit.edu	37	2	44102542	44102542	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:44102542C>G	ENST00000272286.2	+	11	1836	c.1746C>G	c.(1744-1746)agC>agG	p.S582R		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	582	ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				ACTTGAGCAGCCTGTGGACAG	0.577000													8	43					0	0	0.003080	0	0
GFRA1	2674	broad.mit.edu	37	10	117884798	117884798	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:117884798T>C	ENST00000439649.3	-	5	1056	c.689A>G	c.(688-690)tAt>tGt	p.Y230C	GFRA1_ENST00000544592.1_Missense_Mutation_p.Y114C|GFRA1_ENST00000355422.6_Missense_Mutation_p.Y235C|GFRA1_ENST00000369236.1_Missense_Mutation_p.Y230C	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	235					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		CCTCTCTTCATAGGAGCACAC	0.557000													7	48					0	0	0.006214	0	0
CD97	976	broad.mit.edu	37	19	14507186	14507186	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:14507186T>C	ENST00000242786.5	+	5	459	c.379T>C	c.(379-381)Tgt>Cgt	p.C127R	CD97_ENST00000358600.3_Intron|CD97_ENST00000357355.3_Missense_Mutation_p.C127R|CD97_ENST00000587728.1_Intron	NM_078481.3	NP_510966.1	P48960	CD97_HUMAN	CD97 molecule	127	EGF-like 3; calcium-binding (Potential).				cell adhesion|cell-cell signaling|cellular component movement|immune response|inflammatory response|neuropeptide signaling pathway	extracellular space|integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						CCCAAGGCTCTGTAAAAGCTA	0.572000													8	126					0	0	0.004482	0	0
CD44	960	broad.mit.edu	37	11	35223312	35223312	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:35223312G>A	ENST00000428726.2	+	9	1254	c.1131G>A	c.(1129-1131)gaG>gaA	p.E377E	CD44_ENST00000278386.6_Intron|CD44_ENST00000433892.2_Intron|CD44_ENST00000263398.6_Intron|CD44_ENST00000434472.2_Intron|CD44_ENST00000415148.2_Silent_p.E334E|CD44_ENST00000433354.2_Silent_p.E378E|CD44_ENST00000526669.2_Intron|CD44_ENST00000449691.2_Silent_p.E377E|CD44_ENST00000437706.2_Silent_p.E377E|CD44_ENST00000360158.4_Intron|CD44_ENST00000352818.4_Intron	NM_000610.3	NP_000601.3	P16070	CD44_HUMAN	CD44 molecule (Indian blood group)	377	Stem.				cell-cell adhesion|cell-matrix adhesion|interferon-gamma-mediated signaling pathway|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation	cell surface|Golgi apparatus|integral to plasma membrane	collagen binding|hyaluronic acid binding|receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|skin(1)	23	all_cancers(35;0.212)|all_lung(20;0.0874)|all_epithelial(35;0.112)	all_hematologic(20;0.107)	STAD - Stomach adenocarcinoma(6;0.00731)		Hyaluronidase(DB00070)	AGGAAGAAGAGACCCCACATT	0.458000													21	38					0	0	0.008871	0	0
DPP6	1804	broad.mit.edu	37	7	154237702	154237702	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:154237702C>A	ENST00000404039.1	+	4	938	c.351C>A	c.(349-351)ggC>ggA	p.G117G	DPP6_ENST00000332007.3_Silent_p.G119G|DPP6_ENST00000496611.1_3'UTR|DPP6_ENST00000427557.1_Silent_p.G119G|DPP6_ENST00000377770.3_Silent_p.G181G|DPP6_ENST00000406326.1_Silent_p.G181G	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	181					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			TAATAGAAGGCAAAAAAATTG	0.338000													4	16					0.00909568	0.0098961	0.009096	1	0
PTPRD	5789	broad.mit.edu	37	9	8449761	8449761	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:8449761G>T	ENST00000381196.4	-	31	4495	c.3952C>A	c.(3952-3954)Cct>Act	p.P1318T	PTPRD_ENST00000540109.1_Missense_Mutation_p.P1318T|PTPRD_ENST00000360074.4_Missense_Mutation_p.P1305T|PTPRD_ENST00000537002.1_Missense_Mutation_p.P908T|PTPRD_ENST00000358503.5_Missense_Mutation_p.P1296T|PTPRD_ENST00000486161.1_Missense_Mutation_p.P911T|PTPRD_ENST00000356435.5_Missense_Mutation_p.P1318T|PTPRD_ENST00000355233.5_Missense_Mutation_p.P912T|PTPRD_ENST00000397606.3_Missense_Mutation_p.P897T|PTPRD_ENST00000397611.3_Missense_Mutation_p.P908T|PTPRD_ENST00000397617.3_Missense_Mutation_p.P897T	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1318					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.P1318S(2)|p.P789S(1)|p.P912S(1)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AGTTCTACAGGGTCTGTTGGG	0.448000										TSP Lung(15;0.13)			38	118					7.53189e-24	1.54734e-23	0.030466	1	0
LRFN5	145581	broad.mit.edu	37	14	42355965	42355965	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:42355965C>A	ENST00000554171.1	+	5	2569	c.137C>A	c.(136-138)cCa>cAa	p.P46Q	LRFN5_ENST00000554120.1_Missense_Mutation_p.P46Q|LRFN5_ENST00000298119.4_Missense_Mutation_p.P46Q			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	46	LRRNT.					integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		TTATTTGTTCCACCAAACATT	0.408000										HNSCC(30;0.082)			9	35					0.00448238	0.00494808	0.004482	1	0
SDK2	54549	broad.mit.edu	37	17	71431626	71431626	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:71431626G>T	ENST00000392650.3	-	9	1158	c.1158C>A	c.(1156-1158)gcC>gcA	p.A386A	SDK2_ENST00000388726.3_Silent_p.A386A	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	386	Ig-like C2-type 4.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GCACCTCGCCGGCTGCATTGC	0.632000													3	7					0.004672	0.00513241	0.004672	1	0
XIRP2	129446	broad.mit.edu	37	2	167760202	167760202	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:167760202G>T	ENST00000409195.1	+	2	299	c.210G>T	c.(208-210)atG>atT	p.M70I	XIRP2_ENST00000409728.1_Missense_Mutation_p.M70I|XIRP2_ENST00000420519.1_Missense_Mutation_p.M70I|XIRP2_ENST00000295237.9_Missense_Mutation_p.M70I|XIRP2_ENST00000409043.1_Missense_Mutation_p.M70I|XIRP2_ENST00000409756.2_Missense_Mutation_p.M70I	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GGGAAGAGATGTGGAGTTCGA	0.512000													7	37					0.00198382	0.00224459	0.029380	1	0
MFSD1	64747	broad.mit.edu	37	3	158537491	158537491	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:158537491G>T	ENST00000415822.2	+	8	994	c.853G>T	c.(853-855)Gat>Tat	p.D285Y	MFSD1_ENST00000392813.4_Missense_Mutation_p.D246Y|MFSD1_ENST00000264266.8_Missense_Mutation_p.D236Y	NM_022736.2	NP_073573.2	Q9H3U5	MFSD1_HUMAN	major facilitator superfamily domain containing 1	236					transmembrane transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	26			Lung(72;0.00372)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGCCTACTTGGATCAGAGAGC	0.358000													10	42					1.58986e-06	2.1579e-06	0.008291	1	0
CFHR1	3078	broad.mit.edu	37	1	196801077	196801077	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:196801077G>T	ENST00000320493.5	+	6	1029	c.941G>T	c.(940-942)cGa>cTa	p.R314L	CFHR2_ENST00000367421.3_Intron|CFHR1_ENST00000367424.3_Missense_Mutation_p.R255L	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	314	Sushi 5.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						CACACATTGCGAACAACATGT	0.383000													17	57					8.24728e-16	1.57748e-15	0.024334	1	0
GUCY2F	2986	broad.mit.edu	37	X	108684624	108684624	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:108684624G>T	ENST00000218006.2	-	7	1948	c.1657C>A	c.(1657-1659)Cta>Ata	p.L553I		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	553	Protein kinase.				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						GCTGGAGTTAGACTCCCTGAA	0.438000													56	150					3.88204e-17	7.52076e-17	0.014410	1	0
SPEF2	79925	broad.mit.edu	37	5	35800100	35800100	+	Nonsense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:35800100A>T	ENST00000440995.2	+	34	4846	c.4846A>T	c.(4846-4848)Aag>Tag	p.K1616*	SPEF2_ENST00000303129.4_Nonsense_Mutation_p.K418*|CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Nonsense_Mutation_p.K1621*			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1621					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGACTATGAGAAGGATCCACC	0.458000													21	540					0	0	0.018920	0	0
BPI	671	broad.mit.edu	37	20	36952318	36952318	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:36952318C>A	ENST00000262865.4	+	8	904	c.815C>A	c.(814-816)cCa>cAa	p.P272Q	CTD-2308N23.2_ENST00000437016.1_RNA|BPI_ENST00000489102.1_Intron	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	272					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				CCCTTTGCTCCACCAGTGATG	0.527000													12	49					4.3838e-07	6.15906e-07	0.016723	1	0
OSM	5008	broad.mit.edu	37	22	30660136	30660136	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:30660136G>T	ENST00000215781.2	-	3	535	c.495C>A	c.(493-495)ccC>ccA	p.P165P	OSM_ENST00000403389.1_Silent_p.P144P|OSM_ENST00000403463.1_3'UTR	NM_020530.4	NP_065391.1	P13725	ONCM_HUMAN	oncostatin M	165					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|skin(3)	11			Epithelial(10;0.206)			CAGCCTTCGTGGGCTCAGCCG	0.642000													6	40					0.0215528	0.0228285	0.021553	1	0
GRM5	2915	broad.mit.edu	37	11	88780894	88780894	+	Silent	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:88780894C>G	ENST00000418177.2	-	2	514	c.147G>C	c.(145-147)gtG>gtC	p.V49V	GRM5_ENST00000393297.1_Silent_p.V49V|GRM5_ENST00000455756.2_Silent_p.V49V|GRM5_ENST00000305447.4_Silent_p.V49V|GRM5_ENST00000305432.5_Silent_p.V49V|GRM5_ENST00000393294.3_Silent_p.V49V			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	49					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GAACTTTGTCCACAGTAGGCT	0.532000													6	39					0	0	0.021553	0	0
UGT1A4	54657	broad.mit.edu	37	2	234628155	234628155	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:234628155C>T	ENST00000373409.3	+	1	732	c.689C>T	c.(688-690)cCt>cTt	p.P230L	UGT1A6_ENST00000480628.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		TTTTCTGCCCCTTATGCAAGT	0.488000													47	194					0	0	0.014410	0	0
DTNA	1837	broad.mit.edu	37	18	32462098	32462098	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr18:32462098G>T	ENST00000283365.9	+	20	2327	c.1976G>T	c.(1975-1977)cGg>cTg	p.R659L	DTNA_ENST00000598334.1_Missense_Mutation_p.R656L|DTNA_ENST00000556414.3_Missense_Mutation_p.R368L|DTNA_ENST00000399097.3_Missense_Mutation_p.R364L|DTNA_ENST00000444659.1_Missense_Mutation_p.R716L|DTNA_ENST00000601125.1_Missense_Mutation_p.R338L|DTNA_ENST00000592449.1_3'UTR|DTNA_ENST00000591182.1_Missense_Mutation_p.R364L|DTNA_ENST00000399121.5_Missense_Mutation_p.R663L|DTNA_ENST00000399113.3_Missense_Mutation_p.R716L|DTNA_ENST00000269190.7_Missense_Mutation_p.R717L|DTNA_ENST00000590831.2_Missense_Mutation_p.R142L|DTNA_ENST00000595022.1_Missense_Mutation_p.R656L|DTNA_ENST00000598142.1_Missense_Mutation_p.R659L|DTNA_ENST00000269192.7_Missense_Mutation_p.R425L	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	716					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						GACTCTGTCCGGCAGCTGGAG	0.488000													8	33					1.12685e-05	1.46233e-05	0.004482	1	0
SDK2	54549	broad.mit.edu	37	17	71419589	71419589	+	Silent	SNP	C	C	G	rs146912233	by1000genomes	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:71419589C>G	ENST00000392650.3	-	14	1833	c.1833G>C	c.(1831-1833)acG>acC	p.T611T	SDK2_ENST00000388726.3_Silent_p.T611T	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	611	Fibronectin type-III 1.				cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						GCTTGGTCCACGTCAGGTTGA	0.607000													12	15					0	0	0.010729	0	0
CGNL1	84952	broad.mit.edu	37	15	57731566	57731566	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:57731566G>T	ENST00000281282.5	+	2	1447	c.1369G>T	c.(1369-1371)Gcc>Tcc	p.A457S		NM_001252335.1|NM_032866.4	NP_001239264.1|NP_116255.2	Q0VF96	CGNL1_HUMAN	cingulin-like 1	457	Head.					myosin complex|tight junction	motor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(14)|ovary(4)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(1)	60				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		GGCTTCATGTGCCCACTCCAG	0.622000													14	34					7.93312e-07	1.09422e-06	0.020292	1	0
HAP1	9001	broad.mit.edu	37	17	39881192	39881192	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:39881192C>T	ENST00000393939.2	-	10	1555	c.1546G>A	c.(1546-1548)Gag>Aag	p.E516K	HAP1_ENST00000310778.5_Missense_Mutation_p.E593K|HAP1_ENST00000347901.4_Missense_Mutation_p.E541K|HAP1_ENST00000341193.5_Missense_Mutation_p.E524K|JUP_ENST00000540235.1_Intron			P54257	HAP1_HUMAN	huntingtin-associated protein 1	593	Glu-rich.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			TCCACCTCCTCCCAGCCCTCG	0.627000													16	331					0	0	0.028581	0	0
BAGE2	85319	broad.mit.edu	37	21	11038970	11038970	+	RNA	SNP	G	G	T	rs594457	by1000genomes	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr21:11038970G>T	ENST00000470054.1	-	0	1233									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTCTGTCTCAGATGATAACTT	0.418000													17	420					9.16793e-09	1.40094e-08	0.033300	1	0
ARGFX	503582	broad.mit.edu	37	3	121289635	121289635	+	Silent	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:121289635G>C	ENST00000334384.3	+	1	85	c.75G>C	c.(73-75)gtG>gtC	p.V25V		NM_001012659.1	NP_001012677.1	A6NJG6	ARGFX_HUMAN	arginine-fifty homeobox	25						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	15				GBM - Glioblastoma multiforme(114;0.152)		ACATGAAGGTGATACCACCAC	0.463000													6	88					0	0	0.021553	0	0
SPATA31C1	441452	broad.mit.edu	37	9	90535409	90535409	+	RNA	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:90535409C>A	ENST00000602681.1	+	0	1313																											CTAAGTGCCTCCCAGCCACCA	0.617000													66	163					9.4991e-31	2.0506e-30	0.014410	1	0
NAA15	80155	broad.mit.edu	37	4	140291517	140291517	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:140291517G>A	ENST00000296543.5	+	15	2229	c.1906G>A	c.(1906-1908)Gga>Aga	p.G636R	NAA15_ENST00000398947.1_Missense_Mutation_p.G636R	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	636					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						tgaggagataggaggtccaaa	0.358000													5	27					0	0	0.014758	0	0
DMKN	93099	broad.mit.edu	37	19	36003562	36003562	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:36003562A>C	ENST00000339686.3	-	2	733	c.557T>G	c.(556-558)aTg>aGg	p.M186R	DMKN_ENST00000424570.2_Missense_Mutation_p.M186R|DMKN_ENST00000447113.2_Missense_Mutation_p.M186R|DMKN_ENST00000451297.2_Missense_Mutation_p.M186R|DMKN_ENST00000429837.1_Missense_Mutation_p.M186R|DMKN_ENST00000418261.1_Missense_Mutation_p.M186R|DMKN_ENST00000440396.1_Missense_Mutation_p.M186R|DMKN_ENST00000419602.1_Missense_Mutation_p.M186R	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	186	Gly-rich.					extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CTGAGGATTCATTCCAAAGCT	0.607000													8	69					0	0	0.004482	0	0
DDI1	414301	broad.mit.edu	37	11	103908369	103908369	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:103908369C>A	ENST00000302259.3	+	1	1062	c.819C>A	c.(817-819)gcC>gcA	p.A273A	PDGFD_ENST00000302251.5_Intron|PDGFD_ENST00000393158.2_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	273					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		AGGCTTGTGCCGAGCGATGTA	0.517000													32	69					1.45844e-13	2.57594e-13	0.013726	1	0
USP46	64854	broad.mit.edu	37	4	53468093	53468093	+	Missense_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:53468093T>C	ENST00000441222.2	-	7	1034	c.850A>G	c.(850-852)Aac>Gac	p.N284D	USP46_ENST00000451218.2_Missense_Mutation_p.N257D|USP46_ENST00000508499.1_Missense_Mutation_p.N277D	NM_022832.3	NP_073743.2	P62068	UBP46_HUMAN	ubiquitin specific peptidase 46	284					behavior|protein deubiquitination|regulation of synaptic transmission, GABAergic|ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(2)	12			LUSC - Lung squamous cell carcinoma(32;0.0295)			CTGGAGGTGTTGAAGAGCCGG	0.542000													18	49					0	0	0.010504	0	0
CDKL5	6792	broad.mit.edu	37	X	18627664	18627664	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:18627664C>A	ENST00000379989.3	+	15	2411	c.2126C>A	c.(2125-2127)cCa>cAa	p.P709Q	CDKL5_ENST00000379996.3_Missense_Mutation_p.P709Q|CDKL5_ENST00000463994.1_3'UTR	NM_001037343.1	NP_001032420.1	O76039	CDKL5_HUMAN	cyclin-dependent kinase-like 5	709					neuron migration|positive regulation of axon extension|positive regulation of dendrite morphogenesis|positive regulation of Rac GTPase activity|protein autophosphorylation	dendrite cytoplasm|dendritic growth cone|nucleus	ATP binding|cyclin-dependent protein kinase activity|Rac GTPase binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(12)|ovary(4)|skin(5)|stomach(1)	44	Hepatocellular(33;0.183)					GATCCTGTGCCAAGGAGAGTT	0.498000													7	54					8.12818e-05	9.85234e-05	0.029380	1	0
THRAP3	9967	broad.mit.edu	37	1	36752298	36752298	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:36752298G>C	ENST00000354618.5	+	4	691	c.467G>C	c.(466-468)cGc>cCc	p.R156P	THRAP3_ENST00000469141.2_Missense_Mutation_p.R156P	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	156	Arg-rich.|Ser-rich.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CGGTCAAGGCGCTCCTCATCC	0.527000			T	USP6	aneurysmal bone cysts								60	240					0	0	0.014410	0	0
ADCY5	111	broad.mit.edu	37	3	123049747	123049747	+	Silent	SNP	G	G	T	rs144214981	byFrequency	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:123049747G>T	ENST00000462833.1	-	5	2847	c.1635C>A	c.(1633-1635)atC>atA	p.I545I	ADCY5_ENST00000491190.1_Silent_p.I178I|ADCY5_ENST00000309879.5_Silent_p.I195I	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	545	Guanylate cyclase 1.				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		AGATGGCCTCGATCATGTCCA	0.602000													8	25					2.17888e-05	2.74377e-05	0.006214	1	0
CDHR2	54825	broad.mit.edu	37	5	176003034	176003034	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:176003034G>T	ENST00000510636.1	+	12	1316	c.1042G>T	c.(1042-1044)Gac>Tac	p.D348Y	CDHR2_ENST00000506348.1_Missense_Mutation_p.D348Y|CDHR2_ENST00000261944.5_Missense_Mutation_p.D348Y	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	348	Cadherin 3.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						GGACGTCAATGACCACAAACC	0.577000													10	25					1.58986e-06	2.1579e-06	0.008291	1	0
ZNF699	374879	broad.mit.edu	37	19	9408097	9408097	+	Silent	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:9408097T>C	ENST00000591998.1	-	5	573	c.345A>G	c.(343-345)gaA>gaG	p.E115E	ZNF699_ENST00000308650.3_Silent_p.E115E			Q32M78	ZN699_HUMAN	zinc finger protein 699	115					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGGATATTTTTTCTCCACAAA	0.348000													16	44					0	0	0.028581	0	0
PTGER3	5733	broad.mit.edu	37	1	71418718	71418718	+	Missense_Mutation	SNP	G	G	T	rs143165473		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:71418718G>T	ENST00000356595.4	-	4	1339	c.1129C>A	c.(1129-1131)Cag>Aag	p.Q377K	PTGER3_ENST00000414819.1_3'UTR|PTGER3_ENST00000460330.1_Intron|PTGER3_ENST00000370931.3_Intron|PTGER3_ENST00000354608.5_Intron|PTGER3_ENST00000370932.2_Intron|PTGER3_ENST00000351052.5_Intron	NM_198718.1	NP_942011.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	0					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	ctctgtatctgagagttctgc	0.338000													27	93					2.79863e-10	4.53112e-10	0.024334	1	0
ABCC2	1244	broad.mit.edu	37	10	101595910	101595910	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:101595910C>A	ENST00000370449.4	+	25	3590	c.3477C>A	c.(3475-3477)atC>atA	p.I1159I		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1159	ABC transmembrane type-1 2.					apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GGTCCCCAATCTACTCTCACT	0.507000													8	78					0.000157383	0.000186772	0.003080	1	0
HBD	3045	broad.mit.edu	37	11	5255616	5255616	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:5255616C>A	ENST00000380299.3	-	1	262	c.48G>T	c.(46-48)tgG>tgT	p.W16C	HBD_ENST00000292901.3_Missense_Mutation_p.W16C	NM_000519.3	NP_000510.1	P02042	HBD_HUMAN	hemoglobin, delta	16					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			endometrium(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)	16		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;5.69e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCACTTTGCCCCACAGGGCAT	0.502000													28	38					2.47511e-08	3.70721e-08	0.037714	1	0
ZFHX4	79776	broad.mit.edu	37	8	77765793	77765793	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:77765793C>T	ENST00000521891.2	+	10	7084	c.6636C>T	c.(6634-6636)ccC>ccT	p.P2212P	ZFHX4_ENST00000455469.2_Silent_p.P2167P|ZFHX4_ENST00000050961.6_Silent_p.P2167P|ZFHX4_ENST00000518282.1_Silent_p.P2186P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2167						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATCCACAGCCCACCTCTTTAG	0.373000										HNSCC(33;0.089)			13	60					0	0	0.013537	0	0
ERCC1	2067	broad.mit.edu	37	19	45923668	45923668	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:45923668C>T	ENST00000300853.3	-	4	930	c.339G>A	c.(337-339)ctG>ctA	p.L113L	ERCC1_ENST00000340192.7_Silent_p.L113L|ERCC1_ENST00000423698.2_Silent_p.L41L|ERCC1_ENST00000013807.5_Silent_p.L113L|ERCC1_ENST00000589165.1_Silent_p.L113L|ERCC1_ENST00000591636.1_Silent_p.L113L	NM_001983.3	NP_001974.1	P07992	ERCC1_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)	113					mitotic recombination|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to oxidative stress|transcription-coupled nucleotide-excision repair	cytoplasm|nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair complex	damaged DNA binding|endonuclease activity|protein C-terminus binding|protein domain specific binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(2)|ovary(2)|skin(1)	15		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0247)		GCACGAACTTCAGTACGGGAT	0.587000								Nucleotide excision repair (NER)					6	8					0	0	0.021553	0	0
ECT2L	345930	broad.mit.edu	37	6	139170499	139170499	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:139170499C>A	ENST00000423192.1	+	8	1158	c.997C>A	c.(997-999)Ctg>Atg	p.L333M	ECT2L_ENST00000367682.2_Missense_Mutation_p.L333M|ECT2L_ENST00000541398.1_Missense_Mutation_p.L264M			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	333					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						AGAAAAAGCTCTGGATGGGCA	0.463000			"""N, Splice, Mis"""		ETP ALL								18	71					9.7654e-05	0.000118158	0.007413	1	0
RGS8	85397	broad.mit.edu	37	1	182615976	182615976	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:182615976G>T	ENST00000483095.2	-	7	694	c.437C>A	c.(436-438)gCc>gAc	p.A146D	RGS8_ENST00000367557.4_Missense_Mutation_p.A146D|RGS8_ENST00000367556.1_Missense_Mutation_p.A146D|RGS8_ENST00000258302.4_Missense_Mutation_p.A164D			P57771	RGS8_HUMAN	regulator of G-protein signaling 8	146	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	5						TTTTCCTTGGGCTTGGTCAAA	0.502000													32	135					1.06801e-11	1.8021e-11	0.009535	1	0
LCE3D	84648	broad.mit.edu	37	1	152552337	152552337	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:152552337G>T	ENST00000368787.3	-	2	132	c.76C>A	c.(76-78)Cca>Aca	p.P26T		NM_032563.1	NP_115952.1	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	26					keratinization					breast(1)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)|stomach(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		CACTGTACTGGGCTCTTTGGG	0.632000													23	95					2.89027e-11	4.75879e-11	0.014323	1	0
JUP	3728	broad.mit.edu	37	17	39927916	39927916	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:39927916C>G	ENST00000393931.3	-	2	309	c.191G>C	c.(190-192)gGg>gCg	p.G64A	JUP_ENST00000393930.1_Missense_Mutation_p.G64A|JUP_ENST00000310706.5_Missense_Mutation_p.G64A|JUP_ENST00000540235.1_Missense_Mutation_p.G64A	NM_002230.2	NP_002221.1	P14923	PLAK_HUMAN	junction plakoglobin	64					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GGGGGGCACCCCCTGGGTGTA	0.612000													16	39					0	0	0.028581	0	0
GBP4	115361	broad.mit.edu	37	1	89657124	89657124	+	Silent	SNP	G	G	T	rs141089744		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:89657124G>T	ENST00000355754.6	-	6	833	c.736C>A	c.(736-738)Cgg>Agg	p.R246R		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	246						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		AAGCACTTCCGTTTTCGGAAG	0.393000													18	74					1.67942e-08	2.54344e-08	0.006122	1	0
INTS4	92105	broad.mit.edu	37	11	77639510	77639510	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:77639510C>G	ENST00000534064.1	-	11	1283	c.1249G>C	c.(1249-1251)Gtt>Ctt	p.V417L	INTS4_ENST00000529807.1_Missense_Mutation_p.V417L|INTS4_ENST00000525931.1_5'UTR	NM_033547.3	NP_291025.3	Q96HW7	INT4_HUMAN	integrator complex subunit 4	417					snRNA processing	integrator complex	protein binding		INTS4/GAB2(2)	NS(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(9)|ovary(2)|prostate(5)|upper_aerodigestive_tract(1)	32	all_cancers(14;4.53e-19)|all_epithelial(13;1.73e-21)|Breast(9;2.71e-16)|Ovarian(111;0.152)		Epithelial(5;1.13e-46)|all cancers(3;8.92e-44)|BRCA - Breast invasive adenocarcinoma(5;8.4e-26)|OV - Ovarian serous cystadenocarcinoma(8;1.05e-23)			AACATGTCAACTAGGAAATCA	0.438000													10	21					0	0	0.008291	0	0
GLYAT	10249	broad.mit.edu	37	11	58482866	58482866	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:58482866C>A	ENST00000344743.3	-	3	253	c.112G>T	c.(112-114)Gga>Tga	p.G38*	GLYAT_ENST00000278400.3_Nonsense_Mutation_p.G38*|GLYAT_ENST00000529732.1_Nonsense_Mutation_p.G38*	NM_201648.2	NP_964011.2	Q6IB77	GLYAT_HUMAN	glycine-N-acyltransferase	38					acyl-CoA metabolic process|response to toxin|xenobiotic metabolic process	mitochondrial matrix	glycine N-acyltransferase activity|glycine N-benzoyltransferase activity			NS(1)|autonomic_ganglia(1)|kidney(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16		Breast(21;0.0044)|all_epithelial(135;0.0157)			Glycine(DB00145)	AATGGATTTCCATGGTTTATG	0.398000													16	48					3.45872e-05	4.31546e-05	0.028581	1	0
TGM1	7051	broad.mit.edu	37	14	24724007	24724007	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:24724007C>A	ENST00000206765.6	-	13	2074	c.1951G>T	c.(1951-1953)Gcc>Tcc	p.A651S	TGM1_ENST00000544573.1_Missense_Mutation_p.A209S	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	651					cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TCCTTGTAGGCCACTGGCATG	0.627000													13	40					7.03913e-09	1.0805e-08	0.013537	1	0
HOXC10	3226	broad.mit.edu	37	12	54379646	54379646	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:54379646C>A	ENST00000303460.4	+	1	677	c.603C>A	c.(601-603)acC>acA	p.T201T		NM_017409.3	NP_059105.2	Q9NYD6	HXC10_HUMAN	homeobox C10	201					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(14)|pancreas(1)	20						TCCCTGAGACCCCCAAGTCCG	0.632000													12	54					0.00010058	0.000120838	0.013537	1	0
PCSK2	5126	broad.mit.edu	37	20	17462436	17462436	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:17462436G>T	ENST00000262545.2	+	12	1953	c.1638G>T	c.(1636-1638)aaG>aaT	p.K546N	PCSK2_ENST00000459871.1_3'UTR|PCSK2_ENST00000377899.1_Missense_Mutation_p.K527N|PCSK2_ENST00000536609.1_Missense_Mutation_p.K511N	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	546					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACGACTCCAAGGTGGGCTTTG	0.592000													5	46					0.014758	0.0157542	0.014758	1	0
FLG	2312	broad.mit.edu	37	1	152277708	152277708	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:152277708G>C	ENST00000368799.1	-	3	9689	c.9654C>G	c.(9652-9654)gaC>gaG	p.D3218E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3218	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CACTGTCACTGTCCTGGCTCA	0.567000									Ichthyosis				60	246					0	0	0.014410	0	0
MIOX	55586	broad.mit.edu	37	22	50925850	50925850	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:50925850G>T	ENST00000395732.3	+	2	74	c.52G>T	c.(52-54)Gac>Tac	p.D18Y	MIOX_ENST00000395733.3_Missense_Mutation_p.D18Y|MIOX_ENST00000216075.6_Missense_Mutation_p.D18Y			Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	18					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	13		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		ACCTGATGTGGACCCAGAGGT	0.597000													7	42					5.18039e-06	6.89367e-06	0.003080	1	0
FNDC1	84624	broad.mit.edu	37	6	159655446	159655446	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:159655446G>C	ENST00000297267.9	+	11	4102	c.3902G>C	c.(3901-3903)aGg>aCg	p.R1301T	FNDC1_ENST00000340366.6_Missense_Mutation_p.R1238T	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1301						extracellular region		p.R1301M(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		TTGCGCCAGAGGATGATGCAT	0.587000													4	35					0	0	0.014758	0	0
MRAP2	112609	broad.mit.edu	37	6	84765061	84765061	+	Silent	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:84765061T>A	ENST00000257776.4	+	2	159	c.24T>A	c.(22-24)tcT>tcA	p.S8S		NM_138409.2	NP_612418.2	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	8					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(4)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	19						GGTTAATTTCTAACAGAACCT	0.433000													19	76					0	0	0.016522	0	0
MAGEA12	4111	broad.mit.edu	37	X	151900061	151900061	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:151900061G>A	ENST00000393900.3	-	3	1093	c.740C>T	c.(739-741)aCc>aTc	p.T247I	MAGEA12_ENST00000357916.4_Missense_Mutation_p.T247I|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Missense_Mutation_p.T247I	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	247	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					CAAATCTTGGGTGAGCAGCTT	0.577000													52	191					0	0	0.014410	0	0
LETM1	3954	broad.mit.edu	37	4	1834499	1834499	+	Missense_Mutation	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:1834499C>T	ENST00000302787.2	-	6	1348	c.1052G>A	c.(1051-1053)cGg>cAg	p.R351Q		NM_012318.2	NP_036450.1	O95202	LETM1_HUMAN	leucine zipper-EF-hand containing transmembrane protein 1	351	LETM1.				cristae formation	integral to membrane|mitochondrial inner membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(2)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(1)	13			all cancers(2;0.00756)|OV - Ovarian serous cystadenocarcinoma(23;0.00989)|Epithelial(3;0.0141)			GGAGCGCAGCCGCATGGTAAG	0.567000													14	63					0	0	0.028581	0	0
VPS13C	54832	broad.mit.edu	37	15	62161820	62161820	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:62161820C>G	ENST00000261517.5	-	80	10700	c.10627G>C	c.(10627-10629)Gcc>Ccc	p.A3543P	VPS13C_ENST00000395898.3_Missense_Mutation_p.A3500P|VPS13C_ENST00000249837.3_Missense_Mutation_p.A3500P|VPS13C_ENST00000395896.4_Missense_Mutation_p.A3543P	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	3543					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						TCCTTTTTGGCACCTTCAGAA	0.443000													11	89					0	0	0.013537	0	0
SLC6A17	388662	broad.mit.edu	37	1	110714731	110714731	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:110714731C>A	ENST00000331565.4	+	3	821	c.336C>A	c.(334-336)ccC>ccA	p.P112P	RP5-1028L10.1_ENST00000443008.1_RNA	NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	112					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TCGGGATCCCCCTCTTCTTCC	0.627000													3	31					0.00024832	0.000289636	0.009096	1	0
ADAMTS12	81792	broad.mit.edu	37	5	33649757	33649757	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:33649757C>A	ENST00000504830.1	-	8	1571	c.1236G>T	c.(1234-1236)gtG>gtT	p.V412V	ADAMTS12_ENST00000352040.3_Silent_p.V412V|ADAMTS12_ENST00000504582.1_5'UTR	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	412	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GATGTCTGCCCACAGGCTCAC	0.547000										HNSCC(64;0.19)			6	136					0.000157383	0.000186772	0.003080	1	0
CNPY1	285888	broad.mit.edu	37	7	155295764	155295764	+	Nonstop_Mutation	SNP	T	T	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:155295764T>C	ENST00000321736.5	-	4	440	c.278A>G	c.(277-279)tAg>tGg	p.*93W	CNPY1_ENST00000406197.1_Nonstop_Mutation_p.*93W	NM_001103176.1	NP_001096646.1	Q3B7I2	CNPY1_HUMAN	canopy FGF signaling regulator 1	0										breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)	8	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.171)		ACGGCACTCCTAGAGCTCAGT	0.378000													9	24					0	0	0.008291	0	0
CDK12	51755	broad.mit.edu	37	17	37619304	37619304	+	Missense_Mutation	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:37619304A>G	ENST00000447079.4	+	1	1013	c.980A>G	c.(979-981)tAt>tGt	p.Y327C	CDK12_ENST00000430627.2_Missense_Mutation_p.Y327C	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	327					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						CCCAGTCCCTATGGTCGAAGG	0.562000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			17	40					0	0	0.007413	0	0
ZNF385D	79750	broad.mit.edu	37	3	21706379	21706379	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:21706379G>T	ENST00000281523.2	-	2	682	c.165_splice	c.e2+1	p.A55_splice	ZNF385D_ENST00000494118.1_Intron	NM_024697.2	NP_078973.1	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	55						nucleus	nucleic acid binding|zinc ion binding			NS(2)|breast(2)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(1)|prostate(1)|skin(4)	46						GGTACTTACCGCATTGAAATT	0.473000													13	86					1.05317e-09	1.67326e-09	0.020292	1	0
OTOF	9381	broad.mit.edu	37	2	26739403	26739403	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:26739403C>A	ENST00000272371.2	-	5	518	c.392G>T	c.(391-393)gGg>gTg	p.G131V	OTOF_ENST00000403946.3_Missense_Mutation_p.G131V	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	131					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGAAGTCCCCATCGTCCCA	0.647000													20	87					3.73194e-20	7.49822e-20	0.010504	1	0
ZNF697	90874	broad.mit.edu	37	1	120168693	120168693	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:120168693C>A	ENST00000421812.2	-	2	150	c.31G>T	c.(31-33)Gca>Tca	p.A11S		NM_001080470.1	NP_001073939.1	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	11					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		TCCTGGTGTGCACAGACACCC	0.483000													36	150					4.00102e-26	8.44935e-26	0.025465	1	0
BAI1	575	broad.mit.edu	37	8	143561106	143561106	+	Silent	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:143561106G>A	ENST00000517894.1	+	9	2673	c.1779G>A	c.(1777-1779)gaG>gaA	p.E593E	BAI1_ENST00000323289.5_Silent_p.E593E			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	593					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TCTGGAAGGAGACCCCAGCGG	0.642000													12	75					0	0	0.020292	0	0
QRICH2	84074	broad.mit.edu	37	17	74301008	74301008	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr17:74301008C>A	ENST00000262765.5	-	2	230	c.51G>T	c.(49-51)cgG>cgT	p.R17R		NM_032134.1	NP_115510.1	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	17							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(2)|stomach(4)	62						GTTCATCAACCCGCTGTAAAA	0.517000													45	107					2.40228e-13	4.19935e-13	0.013114	1	0
KYNU	8942	broad.mit.edu	37	2	143718199	143718199	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:143718199G>C	ENST00000264170.4	+	8	847	c.589G>C	c.(589-591)Gaa>Caa	p.E197Q	KYNU_ENST00000409512.1_Missense_Mutation_p.E197Q|KYNU_ENST00000375773.2_Missense_Mutation_p.E197Q	NM_003937.2	NP_003928.1	Q16719	KYNU_HUMAN	kynureninase	197					anthranilate metabolic process|NAD biosynthetic process|quinolinate biosynthetic process|response to interferon-gamma|response to vitamin B6	cytosol|mitochondrion|soluble fraction	kynureninase activity|protein homodimerization activity			large_intestine(10)|liver(1)|lung(18)|prostate(3)|skin(4)	36				BRCA - Breast invasive adenocarcinoma(221;0.072)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	TTAGGGGGAAGAAACCTTAAG	0.383000													13	55					0	0	0.024245	0	0
ZNF430	80264	broad.mit.edu	37	19	21216307	21216307	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:21216307G>T	ENST00000261560.5	+	3	323	c.142G>T	c.(142-144)Gag>Tag	p.E48*	ZNF430_ENST00000595401.1_Nonsense_Mutation_p.E48*|ZNF430_ENST00000599548.1_Nonsense_Mutation_p.E48*	NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	48	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						TTCTCTGGAGGAGTGGCAATG	0.448000													34	96					1.45844e-13	2.57594e-13	0.013726	1	0
LAMA1	284217	broad.mit.edu	37	18	7044769	7044769	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr18:7044769G>C	ENST00000389658.3	-	7	1021	c.928C>G	c.(928-930)Cag>Gag	p.Q310E		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	310	Laminin EGF-like 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGGGCTGCTGATGGTACCCA	0.478000													17	116					0	0	0.033300	0	0
OTOGL	283310	broad.mit.edu	37	12	80658799	80658799	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:80658799G>T	ENST00000458043.2	+	19	2012	c.2006G>T	c.(2005-2007)tGt>tTt	p.C669F	OTOGL_ENST00000547103.1_Missense_Mutation_p.C669F	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GCAGCACACTGTGATGTCATC	0.453000													34	163					4.00102e-26	8.44935e-26	0.025465	1	0
IFI44	10561	broad.mit.edu	37	1	79120844	79120844	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:79120844G>T	ENST00000370747.4	+	4	725	c.640G>T	c.(640-642)Gta>Tta	p.V214L	IFI44_ENST00000545124.1_5'UTR|IFI44_ENST00000495254.1_3'UTR	NM_006417.4	NP_006408.3	Q8TCB0	IFI44_HUMAN	interferon-induced protein 44	214					response to virus	cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	21						CCAAGGGCATGTAACGCATCA	0.463000													26	105					2.48779e-11	4.13619e-11	0.027356	1	0
GABRQ	55879	broad.mit.edu	37	X	151819033	151819033	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:151819033G>T	ENST00000370306.2	+	7	911	c.891G>T	c.(889-891)agG>agT	p.R297S		NM_018558.2	NP_061028.2	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) A receptor, theta	297						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCAGCCAGGGTGACAATTG	0.438000													74	248					2.13431e-38	4.69686e-38	0.014410	1	0
PANX3	116337	broad.mit.edu	37	11	124487256	124487256	+	Missense_Mutation	SNP	C	C	A	rs144166888		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:124487256C>A	ENST00000284288.2	+	3	478	c.411C>A	c.(409-411)agC>agA	p.S137R		NM_052959.2	NP_443191.1	Q96QZ0	PANX3_HUMAN	pannexin 3	137					protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|urinary_tract(1)	26	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		CAGCCCTCAGCTCCGATCTGC	0.597000													23	25					2.89027e-11	4.75879e-11	0.014323	1	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	40					0	0	0.004672	0	0
PLEKHA6	22874	broad.mit.edu	37	1	204230557	204230557	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:204230557C>A	ENST00000272203.3	-	7	717	c.401G>T	c.(400-402)cGc>cTc	p.R134L	PLEKHA6_ENST00000485632.1_5'UTR|PLEKHA6_ENST00000414478.1_Missense_Mutation_p.R154L	NM_014935.4	NP_055750.2	Q9Y2H5	PKHA6_HUMAN	pleckstrin homology domain containing, family A member 6	134	PH.									breast(2)|endometrium(6)|kidney(1)|large_intestine(9)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_cancers(21;0.0222)|Breast(84;0.179)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|BRCA - Breast invasive adenocarcinoma(75;0.0833)|Kidney(21;0.0934)|Epithelial(59;0.229)			GAAGTAGGTGCGGACCCCGGC	0.637000													14	33					6.72482e-11	1.09399e-10	0.024245	1	0
PTK7	5754	broad.mit.edu	37	6	43098158	43098158	+	Splice_Site	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:43098158G>A	ENST00000230419.4	+	4	882	c.661_splice	c.e4+1	p.D221_splice	PTK7_ENST00000471863.1_Splice_Site_p.D221_splice|PTK7_ENST00000481273.1_Splice_Site_p.D229_splice|PTK7_ENST00000345201.2_Splice_Site_p.D221_splice|PTK7_ENST00000349241.2_Splice_Site_p.D221_splice|PTK7_ENST00000352931.2_Splice_Site_p.D221_splice	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	221					actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GAGCATTGCTGGTGAGCCTGG	0.612000													3	43					0	0	0.004672	0	0
LAMA5	3911	broad.mit.edu	37	20	60891003	60891003	+	Splice_Site	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:60891003C>A	ENST00000252999.3	-	58	7934		c.e58+1			NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5						angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTCCGCATACCTGTGTCCAT	0.667000													6	8					3.59834e-05	4.45696e-05	0.021553	1	0
STX11	8676	broad.mit.edu	37	6	144508591	144508591	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:144508591G>T	ENST00000367568.4	+	2	1010	c.827G>T	c.(826-828)cGg>cTg	p.R276L		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	276					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		AACCCCTGCCGGACCCTCTGC	0.657000									Familial Hemophagocytic Lymphohistiocytosis				7	22					2.0095e-06	2.71123e-06	0.029380	1	0
MSL2	55167	broad.mit.edu	37	3	135870369	135870369	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:135870369C>A	ENST00000309993.2	-	2	2086	c.1354G>T	c.(1354-1356)Gtg>Ttg	p.V452L	MSL2_ENST00000434835.2_Missense_Mutation_p.V378L	NM_018133.3	NP_060603.2	Q9HCI7	MSL2_HUMAN	male-specific lethal 2 homolog (Drosophila)	452	Lys-rich.				histone H4-K16 acetylation	MSL complex	zinc ion binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(6)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	18						TTTTTGTACACAGTCTTGGTA	0.428000													16	104					2.35188e-11	3.9198e-11	0.006122	1	0
PI16	221476	broad.mit.edu	37	6	36931029	36931029	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:36931029C>A	ENST00000373674.3	+	5	1239	c.911C>A	c.(910-912)cCa>cAa	p.P304Q	PI16_ENST00000491324.1_Intron	NM_001199159.1|NM_153370.2	NP_001186088.1|NP_699201.2	Q6UXB8	PI16_HUMAN	peptidase inhibitor 16	304						extracellular region|integral to membrane	peptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GATGAGGAGCCAGTTACCTTC	0.527000													18	43					1.00905e-13	1.80566e-13	0.008871	1	0
NPAS3	64067	broad.mit.edu	37	14	33684570	33684570	+	Missense_Mutation	SNP	A	A	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr14:33684570A>C	ENST00000346562.2	+	2	307	c.233A>C	c.(232-234)aAc>aCc	p.N78T	NPAS3_ENST00000551008.1_Missense_Mutation_p.N6T|NPAS3_ENST00000357798.5_Missense_Mutation_p.N78T|NPAS3_ENST00000547068.1_Missense_Mutation_p.N6T|NPAS3_ENST00000548645.1_Missense_Mutation_p.N78T|NPAS3_ENST00000551492.1_Missense_Mutation_p.N115T|NPAS3_ENST00000341321.4_Missense_Mutation_p.N108T|NPAS3_ENST00000356141.4_Missense_Mutation_p.N108T	NM_001164749.1|NM_001165893.1|NM_022123.2|NM_173159.2	NP_001158221.1|NP_001159365.1|NP_071406.1|NP_775182.1	Q8IXF0	NPAS3_HUMAN	neuronal PAS domain protein 3	108	Helix-loop-helix motif.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|signal transducer activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	40	Breast(36;0.0102)|Hepatocellular(127;0.133)		LUAD - Lung adenocarcinoma(48;0.00169)|Lung(238;0.00968)	GBM - Glioblastoma multiforme(1;1.31e-09)|all cancers(1;0.000112)|OV - Ovarian serous cystadenocarcinoma(311;0.115)		GACTTTGCTAACCAGGGGGAC	0.478000													24	67					0	0	0.018920	0	0
GLRA4	441509	broad.mit.edu	37	X	102979084	102979084	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:102979084C>A	ENST00000372617.4	-	4	836	c.416G>T	c.(415-417)gGg>gTg	p.G139V		NM_001024452.2	NP_001019623.2	Q5JXX5	GLRA4_HUMAN	glycine receptor, alpha 4	139						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			cervix(1)|endometrium(2)|large_intestine(2)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						GAAGTTGGCCCCTTTCTCATT	0.527000													54	128					1.4374e-25	3.01676e-25	0.014410	1	0
RTP1	132112	broad.mit.edu	37	3	186917596	186917596	+	Missense_Mutation	SNP	T	T	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:186917596T>A	ENST00000312295.4	+	2	560	c.530T>A	c.(529-531)gTg>gAg	p.V177E	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	177					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		CGCATCCACGTGGCCAGCCGC	0.672000													9	23					0	0	0.006214	0	0
LINC00661	126536	broad.mit.edu	37	19	16131434	16131434	+	RNA	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:16131434G>T	ENST00000549354.1	+	0	265				AC004790.3_ENST00000592886.1_lincRNA	NR_026828.1																						CCCTGGAAGTGAAGGTAAGAG	0.627000													4	22					0.00024832	0.000289636	0.009096	1	0
PHF20	51230	broad.mit.edu	37	20	34519200	34519200	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:34519200G>T	ENST00000374012.3	+	15	2263	c.2134G>T	c.(2134-2136)Gac>Tac	p.D712Y	PHF20_ENST00000439301.1_3'UTR			Q9BVI0	PHF20_HUMAN	PHD finger protein 20	712					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			breast(5)|endometrium(1)|kidney(7)|large_intestine(6)|lung(11)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(12;0.00631)|all_lung(11;0.0145)					GTACTGGTATGACAAGGAGTG	0.512000													11	44					1.08611e-07	1.57139e-07	0.010729	1	0
CLDND1	56650	broad.mit.edu	37	3	98237790	98237790	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:98237790C>A	ENST00000503004.1	-	3	1221	c.342G>T	c.(340-342)caG>caT	p.Q114H	CLDND1_ENST00000437922.1_Missense_Mutation_p.Q137H|CLDND1_ENST00000394180.2_Missense_Mutation_p.Q114H|CLDND1_ENST00000394181.2_Missense_Mutation_p.Q114H|CLDND1_ENST00000394185.2_Missense_Mutation_p.Q114H|CLDND1_ENST00000341181.6_Missense_Mutation_p.Q114H|CLDND1_ENST00000510545.1_Missense_Mutation_p.Q114H|CLDND1_ENST00000513287.1_Missense_Mutation_p.Q114H|CLDND1_ENST00000511081.1_Missense_Mutation_p.Q19H|CLDND1_ENST00000508503.1_5'UTR|CLDND1_ENST00000507874.1_Missense_Mutation_p.Q114H|CLDND1_ENST00000502288.1_Missense_Mutation_p.Q19H			Q9NY35	CLDN1_HUMAN	claudin domain containing 1	114						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|ovary(1)	9						TCTCCATGAACTGCTCAGTTA	0.388000													5	33					5.18039e-06	6.89367e-06	0.003080	1	0
TMED1	11018	broad.mit.edu	37	19	10945981	10945981	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:10945981G>A	ENST00000214869.2	-	2	330	c.232C>T	c.(232-234)Cag>Tag	p.Q78*	TMED1_ENST00000588289.1_5'UTR|TMED1_ENST00000591695.1_Nonsense_Mutation_p.Q78*	NM_006858.2	NP_006849.1	Q13445	TMED1_HUMAN	transmembrane emp24 protein transport domain containing 1	78	GOLD.				cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			breast(1)|central_nervous_system(2)|lung(2)|ovary(3)|prostate(1)|skin(1)	10						AGCACGCCCTGAGGGCTCTCC	0.637000													12	96					0	0	0.016723	0	0
LTBP1	4052	broad.mit.edu	37	2	33540297	33540297	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:33540297C>A	ENST00000404816.2	+	24	4044	c.3691C>A	c.(3691-3693)Cag>Aag	p.Q1231K	LTBP1_ENST00000404525.1_Missense_Mutation_p.Q852K|LTBP1_ENST00000418533.2_Missense_Mutation_p.Q905K|LTBP1_ENST00000272273.5_Missense_Mutation_p.Q171K|LTBP1_ENST00000402934.1_Missense_Mutation_p.Q852K|LTBP1_ENST00000407925.1_Missense_Mutation_p.Q905K|LTBP1_ENST00000354476.3_Missense_Mutation_p.Q1232K|LTBP1_ENST00000390003.4_Missense_Mutation_p.Q906K			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1231	EGF-like 12; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGTCTGCCAGCAGGGTTTCTC	0.423000													12	60					1.5842e-08	2.41537e-08	0.016723	1	0
FCHO1	23149	broad.mit.edu	37	19	17892047	17892047	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:17892047G>T	ENST00000594202.1	+	21	1914	c.1635G>T	c.(1633-1635)atG>atT	p.M545I	FCHO1_ENST00000595033.1_Missense_Mutation_p.M495I|FCHO1_ENST00000539407.1_Missense_Mutation_p.M545I|FCHO1_ENST00000600676.1_Missense_Mutation_p.M545I|FCHO1_ENST00000252771.7_Missense_Mutation_p.M545I|FCHO1_ENST00000596951.1_Missense_Mutation_p.M545I|FCHO1_ENST00000597512.1_Missense_Mutation_p.M552I|FCHO1_ENST00000596536.1_Missense_Mutation_p.M545I|FCHO1_ENST00000389133.4_Missense_Mutation_p.M545I	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	545	Pro-rich.									NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						TAGACCTGATGCCTGCACCTG	0.627000													11	122					1.08611e-07	1.57139e-07	0.010729	1	0
C7orf60	154743	broad.mit.edu	37	7	112555434	112555434	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:112555434C>A	ENST00000297145.4	-	2	394	c.229G>T	c.(229-231)Gca>Tca	p.A77S	C7orf60_ENST00000485446.1_5'UTR	NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	77										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						TTTTTCATTGCAACGGCATAT	0.348000													18	70					3.41278e-10	5.47333e-10	0.033300	1	0
NOL8	55035	broad.mit.edu	37	9	95069173	95069173	+	Missense_Mutation	SNP	T	T	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:95069173T>G	ENST00000545558.1	-	11	3312	c.2820A>C	c.(2818-2820)aaA>aaC	p.K940N	NOL8_ENST00000442668.2_Missense_Mutation_p.K940N|NOL8_ENST00000358855.4_Missense_Mutation_p.K872N|NOL8_ENST00000542053.1_Missense_Mutation_p.K872N|NOL8_ENST00000535387.1_Missense_Mutation_p.K902N			Q76FK4	NOL8_HUMAN	nucleolar protein 8	940					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						CATACTTAAATTTCTTAGCAG	0.343000													38	92					0	0	0.036044	0	0
HAVCR2	84868	broad.mit.edu	37	5	156533689	156533689	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:156533689G>C	ENST00000307851.4	-	2	1073	c.343C>G	c.(343-345)Cca>Gca	p.P115A	CTB-120L21.1_ENST00000517708.1_RNA|HAVCR2_ENST00000522593.1_Missense_Mutation_p.P115A|HAVCR2_ENST00000517358.1_5'UTR	NM_032782.4	NP_116171.3	Q8TDQ0	HAVR2_HUMAN	hepatitis A virus cellular receptor 2	115	Ig-like V-type.					integral to membrane				cervix(1)|large_intestine(4)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			ATTATGCCTGGGATTTGGATC	0.428000													6	99					0	0	0.021553	0	0
NAA15	80155	broad.mit.edu	37	4	140291483	140291483	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:140291483G>C	ENST00000296543.5	+	15	2195	c.1872G>C	c.(1870-1872)caG>caC	p.Q624H	NAA15_ENST00000398947.1_Missense_Mutation_p.Q624H	NM_057175.3	NP_476516.1	Q9BXJ9	NAA15_HUMAN	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	624					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			NS(1)|endometrium(3)|large_intestine(7)|liver(2)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29						agagaaatcagaaaaagaaga	0.358000													4	21					0	0	0.009096	0	0
C19orf59	199675	broad.mit.edu	37	19	7742605	7742605	+	Silent	SNP	G	G	T	rs142098368	by1000genomes	TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:7742605G>T	ENST00000333598.3	+	2	631	c.177G>T	c.(175-177)acG>acT	p.T59T	C19orf59_ENST00000597445.1_Intron	NM_174918.2	NP_777578.2	Q8IX19	MCEM1_HUMAN	chromosome 19 open reading frame 59	59						integral to membrane				endometrium(1)|lung(2)|skin(1)|stomach(1)	5						CACGACCCACGAGCCAAGGTG	0.602000											OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	26					0.00116845	0.00132867	0.021553	1	0
KCNE4	23704	broad.mit.edu	37	2	223917945	223917945	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:223917945G>C	ENST00000281830.3	+	2	881	c.550G>C	c.(550-552)Gac>Cac	p.D184H	KCNE4_ENST00000488477.2_Intron|KCNE4_ENST00000604125.1_Missense_Mutation_p.D133H			Q8WWG9	KCNE4_HUMAN	potassium voltage-gated channel, Isk-related family, member 4	133						integral to membrane	voltage-gated potassium channel activity			large_intestine(2)|lung(5)|ovary(2)|skin(1)	10		Renal(207;0.0183)|Lung NSC(271;0.137)|all_lung(227;0.175)		Epithelial(121;4.48e-11)|all cancers(144;2.88e-08)|Lung(261;0.00688)|LUSC - Lung squamous cell carcinoma(224;0.008)		CTCCTCCCCGGACGTGCACCT	0.642000													5	33					0	0	0.014758	0	0
GPR32	2854	broad.mit.edu	37	19	51274755	51274755	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:51274755G>T	ENST00000270590.4	+	1	1035	c.898G>T	c.(898-900)Gct>Tct	p.A300S		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	300						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CATCCTCCAGGCTAGCTTTGC	0.522000													41	62					2.95478e-19	5.84084e-19	0.033182	1	0
SEMA6D	80031	broad.mit.edu	37	15	48053408	48053408	+	Silent	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:48053408C>A	ENST00000316364.5	+	5	775	c.336C>A	c.(334-336)ggC>ggA	p.G112G	SEMA6D_ENST00000537942.1_Silent_p.G112G|SEMA6D_ENST00000354744.4_Silent_p.G112G|SEMA6D_ENST00000389425.3_Silent_p.G112G|SEMA6D_ENST00000358066.4_Silent_p.G112G|SEMA6D_ENST00000558014.1_Silent_p.G112G|SEMA6D_ENST00000558816.1_Silent_p.G112G|SEMA6D_ENST00000355997.3_Silent_p.G112G|SEMA6D_ENST00000389428.3_Silent_p.G112G|SEMA6D_ENST00000389433.2_Silent_p.G112G|SEMA6D_ENST00000389432.2_Silent_p.G112G|SEMA6D_ENST00000536845.2_Silent_p.G112G	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	112	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		CTATGAAAGGCAAGCATAAAG	0.373000													5	42					3.59834e-05	4.45696e-05	0.021553	1	0
HOXC10	3226	broad.mit.edu	37	12	54379647	54379647	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:54379647C>A	ENST00000303460.4	+	1	678	c.604C>A	c.(604-606)Ccc>Acc	p.P202T		NM_017409.3	NP_059105.2	Q9NYD6	HXC10_HUMAN	homeobox C10	202					positive regulation of cell proliferation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(14)|pancreas(1)	20						CCCTGAGACCCCCAAGTCCGA	0.637000													12	54					0.00010058	0.000120838	0.013537	1	0
OR52K2	119774	broad.mit.edu	37	11	4471034	4471034	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:4471034G>T	ENST00000325719.4	+	1	510	c.465G>T	c.(463-465)gtG>gtT	p.V155V		NM_001005172.2	NP_001005172.2	Q8NGK3	O52K2_HUMAN	olfactory receptor, family 52, subfamily K, member 2	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|skin(6)	25		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;1.48e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0821)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCCGGGCTGTGACACTAATGA	0.567000													39	63					1.66425e-11	2.78056e-11	0.021022	1	0
MYO3A	53904	broad.mit.edu	37	10	26455006	26455006	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:26455006C>A	ENST00000265944.5	+	27	3176	c.3010C>A	c.(3010-3012)Ctc>Atc	p.L1004I	MYO3A_ENST00000543632.1_Intron	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	1004	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						GTACTACCTTCTCTGCTACAA	0.493000													11	233					0.000151284	0.000181115	0.016723	1	0
UBR1	197131	broad.mit.edu	37	15	43374882	43374882	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:43374882C>G	ENST00000290650.4	-	3	449	c.371G>C	c.(370-372)tGt>tCt	p.C124S	UBR1_ENST00000382177.2_Missense_Mutation_p.C124S	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	124					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GCAGTCCATACAGAGTACACA	0.378000													4	54					0	0	0.009096	0	0
LAMB1	3912	broad.mit.edu	37	7	107564713	107564713	+	Missense_Mutation	SNP	A	A	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr7:107564713A>T	ENST00000393561.1	-	31	5442	c.5258T>A	c.(5257-5259)cTt>cAt	p.L1753H	LAMB1_ENST00000222399.6_Missense_Mutation_p.L1729H			P07942	LAMB1_HUMAN	laminin, beta 1	1729	Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGAGCTAAAAGAGTTTTTGC	0.333000													16	74					0	0	0.008871	0	0
NALCN	259232	broad.mit.edu	37	13	101944630	101944630	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr13:101944630C>A	ENST00000251127.6	-	8	968	c.887G>T	c.(886-888)tGg>tTg	p.W296L	NALCN_ENST00000376196.3_Missense_Mutation_p.W296L|NALCN_ENST00000470333.1_5'UTR	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	296						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GTAGGAACGCCAACGGGGAAA	0.458000													13	22					2.27111e-07	3.21741e-07	0.013537	1	0
USP7	7874	broad.mit.edu	37	16	8999094	8999094	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:8999094C>A	ENST00000344836.4	-	14	1721	c.1523G>T	c.(1522-1524)cGa>cTa	p.R508L	USP7_ENST00000381886.4_Missense_Mutation_p.R492L|USP7_ENST00000535863.1_Missense_Mutation_p.R409L	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	508					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						AGTGCAGTGTCGAACAGACAG	0.433000											OREG0023595	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	93					0.00244969	0.00276251	0.020292	1	0
SCRN3	79634	broad.mit.edu	37	2	175263030	175263030	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:175263030G>T	ENST00000272732.6	+	2	101	c.19G>T	c.(19-21)Gac>Tac	p.D7Y	SCRN3_ENST00000409673.3_Intron	NM_001193528.1|NM_024583.4	NP_001180457.1|NP_078859.2	Q0VDG4	SCRN3_HUMAN	secernin 3	7					proteolysis		dipeptidase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|urinary_tract(3)	13			OV - Ovarian serous cystadenocarcinoma(117;0.229)			TTTTTCCTGTGACACTTTCGT	0.279000													10	61					6.40141e-05	7.87154e-05	0.010729	1	0
FAT1	2195	broad.mit.edu	37	4	187541782	187541782	+	Silent	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:187541782C>T	ENST00000441802.2	-	10	6167	c.5958G>A	c.(5956-5958)gcG>gcA	p.A1986A		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	1986	Cadherin 18.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding	p.A1989A(2)|p.A1986A(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						CTTTCACTACCGCAGAGTAGA	0.438000										HNSCC(5;0.00058)			63	172					0	0	0.014410	0	0
GPR148	344561	broad.mit.edu	37	2	131487397	131487397	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:131487397C>G	ENST00000309926.4	+	1	755	c.673C>G	c.(673-675)Ctg>Gtg	p.L225V		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	225						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					CACCTCCATTCTGTGCGTTCT	0.562000													10	87					0	0	0.016723	0	0
C7	730	broad.mit.edu	37	5	40972553	40972553	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:40972553C>A	ENST00000313164.9	+	15	2290	c.1931C>A	c.(1930-1932)cCc>cAc	p.P644H		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	644	Sushi 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				CAGAGTCACCCCCAAAAACCT	0.448000													14	95					9.31168e-06	1.22003e-05	0.016723	1	0
CD5L	922	broad.mit.edu	37	1	157809178	157809178	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:157809178G>T	ENST00000368174.4	-	2	147	c.51C>A	c.(49-51)ttC>ttA	p.F17L	CD5L_ENST00000484609.1_5'UTR	NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	17					apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			TCTTACCTAGGAATCCAGGTC	0.443000													11	67					7.03913e-09	1.0805e-08	0.013537	1	0
EPHA5	2044	broad.mit.edu	37	4	66467571	66467571	+	Missense_Mutation	SNP	C	C	G			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr4:66467571C>G	ENST00000273854.3	-	3	1298	c.698G>C	c.(697-699)tGc>tCc	p.C233S	EPHA5_ENST00000511294.1_Missense_Mutation_p.C233S|EPHA5_ENST00000354839.4_Missense_Mutation_p.C233S|EPHA5_ENST00000432638.2_Missense_Mutation_p.C233S	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	233	Cys-rich.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						CACAGAAGGGCATTTTTTATA	0.448000										TSP Lung(17;0.13)			14	25					0	0	0.020292	0	0
ZNF567	163081	broad.mit.edu	37	19	37211274	37211274	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:37211274G>T	ENST00000585696.1	+	3	2785	c.1555G>T	c.(1555-1557)Gta>Tta	p.V519L	ZNF567_ENST00000392163.2_Missense_Mutation_p.V519L|ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000360729.4_Missense_Mutation_p.V519L|ZNF567_ENST00000588311.1_Missense_Mutation_p.V519L|ZNF567_ENST00000536254.2_Missense_Mutation_p.V550L			Q8N184	ZN567_HUMAN	zinc finger protein 567	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			AACCCTCACTGTACATCAGAA	0.408000													26	123					6.12954e-19	1.20465e-18	0.024334	1	0
ANKRD55	79722	broad.mit.edu	37	5	55407117	55407117	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:55407117G>T	ENST00000341048.4	-	10	1609	c.1458C>A	c.(1456-1458)tgC>tgA	p.C486*	ANKRD55_ENST00000434982.2_Nonsense_Mutation_p.C198*|ANKRD55_ENST00000504958.2_Nonsense_Mutation_p.C443*	NM_024669.2	NP_078945.2	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55	485										breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(1)	34		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				GTAACATCTGGCAGCCAGTTC	0.453000													50	128					6.14515e-18	1.20078e-17	0.014410	1	0
LRP1B	53353	broad.mit.edu	37	2	141055532	141055532	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:141055532G>C	ENST00000389484.3	-	84	13783	c.12812C>G	c.(12811-12813)cCc>cGc	p.P4271R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4271	EGF-like 11.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.P4271H(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCTGCAGGTGGGTCTCCCTAT	0.403000										TSP Lung(27;0.18)			11	137					0	0	0.010729	0	0
SLC39A12	221074	broad.mit.edu	37	10	18266980	18266980	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr10:18266980G>T	ENST00000377369.2	+	5	1174	c.901G>T	c.(901-903)Gat>Tat	p.D301Y	SLC39A12_ENST00000377371.3_Missense_Mutation_p.D301Y|SLC39A12_ENST00000539911.1_Missense_Mutation_p.D167Y|SLC39A12_ENST00000377374.4_Missense_Mutation_p.D301Y	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	301					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						AGAGTCTGAGGATGGTCCAGT	0.368000													18	54					1.99824e-07	2.84864e-07	0.033300	1	0
MYT1L	23040	broad.mit.edu	37	2	1890380	1890380	+	Splice_Site	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:1890380C>A	ENST00000399161.2	-	18	3390		c.e18-1		MYT1L_ENST00000428368.2_Splice_Site	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like						cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		GCCAGACAGACTGTAAGACAG	0.448000													6	36					5.9392e-07	8.30999e-07	0.021553	1	0
LAT	27040	broad.mit.edu	37	16	28996747	28996747	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:28996747G>T	ENST00000395456.2	+	1	331	c.9G>T	c.(7-9)gaG>gaT	p.E3D	LAT_ENST00000360872.5_Missense_Mutation_p.E3D|LAT_ENST00000563964.1_3'UTR|LAT_ENST00000566177.1_Missense_Mutation_p.E3D|LAT_ENST00000454369.2_Missense_Mutation_p.E3D|LAT_ENST00000395461.3_Missense_Mutation_p.E39D|LAT_ENST00000354453.4_Missense_Mutation_p.E3D|LAT_ENST00000564277.1_Missense_Mutation_p.E3D|RP11-264B17.3_ENST00000569969.1_RNA	NM_001014987.1|NM_001014988.1|NM_014387.3	NP_001014987.1|NP_001014988.1|NP_055202.1	O43561	LAT_HUMAN	linker for activation of T cells	3					calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|Ras protein signal transduction|regulation of T cell activation|T cell receptor signaling pathway	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity			large_intestine(2)|lung(3)|urinary_tract(1)	6		Hepatocellular(780;0.244)				AGATGGAGGAGGCCATCCTGG	0.657000													5	64					1.024e-07	1.49746e-07	0.014758	1	0
DLGAP2	9228	broad.mit.edu	37	8	1624783	1624783	+	Splice_Site	SNP	C	C	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:1624783C>T	ENST00000421627.2	+	8	2181	c.2048_splice	c.e8+1	p.R683_splice		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	762					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AGATGAGAAGCGGTAACTCAG	0.582000													5	9					0	0	0.014758	0	0
SNHG14	104472715	broad.mit.edu	37	15	25336954	25336954	+	RNA	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:25336954C>A	ENST00000546682.1	+	0	969				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA|SNORD116-23_ENST00000384645.1_RNA	NR_003361.1																						GACCTCAATACATGCATTCCT	0.473000													25	171					1.77063e-15	3.33526e-15	0.027356	1	0
LARP1	23367	broad.mit.edu	37	5	154179189	154179189	+	Missense_Mutation	SNP	G	G	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr5:154179189G>C	ENST00000336314.4	+	9	1209	c.1185G>C	c.(1183-1185)gaG>gaC	p.E395D		NM_015315.3	NP_056130.2	Q6PKG0	LARP1_HUMAN	La ribonucleoprotein domain family, member 1	472							protein binding|RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	33	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TCGTTGATGAGAAAGTTCGTA	0.473000													10	105					0	0	0.010729	0	0
SLC9A9	285195	broad.mit.edu	37	3	143292936	143292936	+	Missense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:143292936G>T	ENST00000316549.6	-	8	1202	c.994C>A	c.(994-996)Cta>Ata	p.L332I		NM_173653.3	NP_775924.1	Q8IVB4	SL9A9_HUMAN	solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9	332					regulation of pH	integral to membrane|late endosome membrane|recycling endosome	sodium:hydrogen antiporter activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(13)|lung(29)|ovary(2)|skin(3)|stomach(1)	57						TGACCTGTTAGGCCGGCAGCC	0.537000													14	41					2.23348e-06	3.00152e-06	0.028581	1	0
TUBA1A	7846	broad.mit.edu	37	12	49580492	49580492	+	Missense_Mutation	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:49580492C>A	ENST00000301071.7	-	2	472	c.128G>T	c.(127-129)gGg>gTg	p.G43V	TUBA1A_ENST00000550767.1_Missense_Mutation_p.G8V|TUBA1A_ENST00000546918.1_Missense_Mutation_p.G43V|TUBA1A_ENST00000295766.5_Missense_Mutation_p.G43V	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	43					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						ATCTCCTCCCCCAATGGTCTT	0.577000													21	84					3.5997e-14	6.54491e-14	0.014323	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76569441	76569441	+	Splice_Site	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr16:76569441G>T	ENST00000307431.8	+	19	3137		c.e19-1		CNTNAP4_ENST00000469589.1_Splice_Site|CNTNAP4_ENST00000377504.4_Splice_Site|CNTNAP4_ENST00000478060.1_Splice_Site|CNTNAP4_ENST00000476707.1_Splice_Site	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4						cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						TTCCCTTTTAGGTGGAACGGC	0.463000													13	29					4.3838e-07	6.15906e-07	0.016723	1	0
PLD3	23646	broad.mit.edu	37	19	40872767	40872767	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:40872767G>A	ENST00000409587.1	+	5	587	c.190G>A	c.(190-192)Gac>Aac	p.D64N	PLD3_ENST00000409419.1_Missense_Mutation_p.D64N|PLD3_ENST00000409735.4_Missense_Mutation_p.D64N|PLD3_ENST00000356508.5_Missense_Mutation_p.D64N|PLD3_ENST00000409281.1_Missense_Mutation_p.D64N			Q8IV08	PLD3_HUMAN	phospholipase D family, member 3	64					lipid catabolic process	endoplasmic reticulum membrane|integral to membrane	NAPE-specific phospholipase D activity|phospholipase D activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	20			Lung(22;0.000636)|LUSC - Lung squamous cell carcinoma(20;0.00248)			GGAATACGGCGACTTGCATCT	0.627000													15	118					0	0	0.028581	0	0
STS	412	broad.mit.edu	37	X	7171273	7171273	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:7171273G>T	ENST00000217961.4	+	2	268	c.48G>T	c.(46-48)ctG>ctT	p.L16L		NM_000351.4	NP_000342.2	P08842	STS_HUMAN	steroid sulfatase (microsomal), isozyme S	16					female pregnancy|steroid catabolic process	endoplasmic reticulum membrane|endosome|Golgi apparatus|integral to membrane|lysosome|microsome|plasma membrane	metal ion binding|steryl-sulfatase activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|prostate(2)|skin(1)	27		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)			Estrone(DB00655)	TGTTCTTTCTGTGGGAAGCCG	0.498000									Ichthyosis				10	39					1.76689e-08	2.65229e-08	0.006214	1	0
PREX2	80243	broad.mit.edu	37	8	69028086	69028086	+	Missense_Mutation	SNP	G	G	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:69028086G>A	ENST00000288368.4	+	26	3522	c.3245G>A	c.(3244-3246)aGc>aAc	p.S1082N		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1082					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GAAAGAAACAGCAAACGGGTA	0.398000													29	74					0	0	0.012213	0	0
MASP1	5648	broad.mit.edu	37	3	186980341	186980341	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr3:186980341G>T	ENST00000337774.5	-	3	794	c.405C>A	c.(403-405)taC>taA	p.Y135*	MASP1_ENST00000392470.2_Nonsense_Mutation_p.Y109*|MASP1_ENST00000296280.6_Nonsense_Mutation_p.Y135*|MASP1_ENST00000392472.2_Nonsense_Mutation_p.Y22*|MASP1_ENST00000495249.1_Intron|MASP1_ENST00000169293.6_Nonsense_Mutation_p.Y135*	NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	135	CUB 1.|Homodimerization (By similarity).|Interaction with FCN2.|Interaction with MBL2.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CCACAGCCATGTAGTGGGCAT	0.522000													12	45					3.07112e-06	4.10287e-06	0.010729	1	0
IGLV5-48	28780	broad.mit.edu	37	22	22707535	22707535	+	RNA	SNP	C	C	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr22:22707535C>A	ENST00000390293.1	+	0	123																											GACTCACCTGCACCTTGCGCA	0.547000													70	167					4.09166e-32	8.88923e-32	0.014410	1	0
ZNF208	7757	broad.mit.edu	37	19	22154080	22154080	+	Silent	SNP	G	G	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr19:22154080G>T	ENST00000397126.4	-	4	3904	c.3756C>A	c.(3754-3756)ccC>ccA	p.P1252P	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				CACATTTGTAGGGTTTCTCTC	0.373000													13	48					7.03913e-09	1.0805e-08	0.013537	1	0
ESPN	83715	broad.mit.edu	37	1	6520177	6520178	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:6520177_6520178insT	ENST00000377828.1	+	13	2704_2705	c.2536_2537insT	c.(2536-2538)gaafs	p.E846fs	ESPN_ENST00000461727.1_Frame_Shift_Ins_p.E280fs|ESPN_ENST00000416731.1_Frame_Shift_Ins_p.E280fs	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	846					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		ACAGGTCATCCTGAAGAAGGGG	0.668													14	45	---	---	---	---					
PHGDH	26227	broad.mit.edu	37	1	120279767	120279768	+	Frame_Shift_Ins	INS	-	-	A	rs150995624		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:120279767_120279768insA	ENST00000369407.3	+	7	2228_2229	c.721_722insA	c.(721-723)tgafs	p.*241fs	PHGDH_ENST00000369409.4_Frame_Shift_Ins_p.*275fs			O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	275					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	18	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	CTTGGTGGACCATGAGAATGTC	0.609													16	42	---	---	---	---					
RYR2	6262	broad.mit.edu	37	1	237993848	237993848	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr1:237993848delG	ENST00000366574.2	+	103	14991	c.14674delG	c.(14674-14676)ggfs	p.G4892fs	RYR2_ENST00000360064.6_Frame_Shift_Del_p.G4898fs|RYR2_ENST00000542537.1_Frame_Shift_Del_p.G4876fs|RYR2_ENST00000462585.1_3'UTR	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4892					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CTTCATCTGTGGGATAGGCAA	0.433													27	121	---	---	---	---					
XIRP2	129446	broad.mit.edu	37	2	168103030	168103030	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr2:168103030delG	ENST00000409195.1	+	9	5217	c.5128delG	c.(5128-5130)gtfs	p.G1711fs	XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Frame_Shift_Del_p.G1489fs|XIRP2_ENST00000295237.9_Frame_Shift_Del_p.G1711fs|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1536					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGAAGTAATAGGTGGTGATGT	0.338													20	71	---	---	---	---					
SCAND3	114821	broad.mit.edu	37	6	28541080	28541081	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:28541080_28541081insT	ENST00000452236.2	-	4	3202_3203	c.2585_2586insA	c.(2584-2586)aaafs	p.K862fs		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	862					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						gagctaccttctttgctgcaga	0.416													22	175	---	---	---	---					
VNN3	55350	broad.mit.edu	37	6	133045931	133045932	+	Frame_Shift_Ins	INS	-	-	A	rs45513497		TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:133045931_133045932insA	ENST00000207771.3	-	6	1085_1086	c.1013_1014insT	c.(1012-1014)cggfs	p.R338fs	VNN3_ENST00000427187.2_3'UTR|VNN3_ENST00000425515.2_3'UTR|VNN3_ENST00000367927.5_3'UTR|VNN3_ENST00000423615.2_3'UTR|VNN3_ENST00000417437.2_3'UTR|VNN3_ENST00000275223.3_3'UTR|VNN3_ENST00000519686.2_3'UTR|VNN3_ENST00000509351.1_3'UTR|VNN3_ENST00000392393.3_3'UTR|VNN3_ENST00000414302.2_3'UTR					vanin 3											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(1)|stomach(1)	8	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00242)|GBM - Glioblastoma multiforme(226;0.0168)		AAATCATCCCCAGAAAATCTGA	0.460													15	77	---	---	---	---					
OPRM1	4988	broad.mit.edu	37	6	154410994	154410994	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr6:154410994delC	ENST00000414028.2	+	2	374	c.324delC	c.(322-324)tafs	p.Y108fs	OPRM1_ENST00000524163.1_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000518759.1_Frame_Shift_Del_p.Y27fs|OPRM1_ENST00000330432.7_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000522236.1_Frame_Shift_Del_p.Y8fs|OPRM1_ENST00000435918.2_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000452687.2_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000419506.2_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000434900.2_Frame_Shift_Del_p.Y201fs|OPRM1_ENST00000360422.4_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000520708.1_Frame_Shift_Del_p.Y8fs|OPRM1_ENST00000229768.5_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000428397.2_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000337049.4_Frame_Shift_Del_p.Y108fs|OPRM1_ENST00000522555.1_Frame_Shift_Del_p.Y8fs	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	108					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	CCAACATCTACATTTTCAACC	0.433													28	87	---	---	---	---					
SNTG1	54212	broad.mit.edu	37	8	51664620	51664620	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:51664620delC	ENST00000522124.1	+	18	2005	c.1344delC	c.(1342-1344)agfs	p.S448fs	SNTG1_ENST00000518864.1_Frame_Shift_Del_p.S448fs|SNTG1_ENST00000517473.1_Intron|SNTG1_ENST00000276467.5_Intron	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	448					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				ATGGCAAGAGCAAAATCAAAT	0.358													29	90	---	---	---	---					
TRPA1	8989	broad.mit.edu	37	8	72967791	72967791	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:72967791delC	ENST00000262209.4	-	12	1616	c.1409delG	c.(1408-1410)atfs	p.S470fs	RP11-383H13.1_ENST00000457356.4_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	470						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	CCTCGTATCACTTATGTCTTG	0.388													14	63	---	---	---	---					
TRIB1	10221	broad.mit.edu	37	8	126448538	126448539	+	Frame_Shift_Ins	INS	-	-	TC			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr8:126448538_126448539insTC	ENST00000311922.3	+	3	1526_1527	c.944_945insTC	c.(943-945)acgfs	p.T315fs	TRIB1_ENST00000519576.1_Frame_Shift_Ins_p.T84fs|TRIB1_ENST00000520847.1_Frame_Shift_Ins_p.T149fs	NM_025195.2	NP_079471.1	Q96RU8	TRIB1_HUMAN	tribbles pseudokinase 1	315	Protein kinase.				JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			NS(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			AGGTGCCTCATTCGCAGCCTCT	0.574													16	142	---	---	---	---					
PAPPA	5069	broad.mit.edu	37	9	118949903	118949904	+	Frame_Shift_Ins	INS	-	-	C			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr9:118949903_118949904insC	ENST00000328252.3	+	2	1255_1256	c.886_887insC	c.(886-888)ctgfs	p.L296fs		NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	296	Metalloprotease.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						TGTGAAGCATGCCTGGTCCCCC	0.584													15	34	---	---	---	---					
KIAA1549L	25758	broad.mit.edu	37	11	33604956	33604958	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr11:33604956_33604958delTCA	ENST00000321505.4	+	10	3764_3766	c.3584_3586delTCA	c.(3583-3588)gtc>g	p.VI1195del	KIAA1549L_ENST00000389726.3_In_Frame_Del_p.VI1201del|KIAA1549L_ENST00000265654.5_In_Frame_Del_p.VI1201del					KIAA1549-like																		GTGGTCACGGTCATCATCATCAT	0.547													2	4	---	---	---	---					
TRHDE	29953	broad.mit.edu	37	12	73014906	73014907	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr12:73014906_73014907insT	ENST00000261180.4	+	14	2449_2450	c.2353_2354insT	c.(2353-2355)tgcfs	p.C785fs		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	785					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TTTAAAGCAAGTTGCAACAACA	0.292													14	55	---	---	---	---					
POSTN	10631	broad.mit.edu	37	13	38158979	38158980	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr13:38158979_38158980insA	ENST00000379747.4	-	8	1098_1099	c.981_982insT	c.(979-984)aacaatfs	p.N328fs	POSTN_ENST00000541179.1_Frame_Shift_Ins_p.N328fs|POSTN_ENST00000379742.4_Frame_Shift_Ins_p.N328fs|POSTN_ENST00000541481.1_Frame_Shift_Ins_p.N328fs|POSTN_ENST00000379743.4_Frame_Shift_Ins_p.N328fs|POSTN_ENST00000379749.4_Frame_Shift_Ins_p.N328fs	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	328	FAS1 2.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		ATCTCAATTGTATTTCCTTCCA	0.376													17	39	---	---	---	---					
LOC101927079	101927079	broad.mit.edu	37	15	22332413	22332413	+	RNA	DEL	A	A	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:22332413delA	ENST00000558896.1	+	0	220																											TGGCTTGATGAAAAAAAACAA	0.323													12	84	---	---	---	---					
ADAL	161823	broad.mit.edu	37	15	43638085	43638086	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr15:43638085_43638086delTT	ENST00000422466.2	+	9	1033_1034	c.459_460delTT	c.(457-462)cctafs	p.PL153fs	ADAL_ENST00000428046.3_Frame_Shift_Del_p.PL153fs|ADAL_ENST00000562188.1_Frame_Shift_Del_p.PL153fs|ADAL_ENST00000389651.4_Frame_Shift_Del_p.PL153fs			Q6DHV7	ADAL_HUMAN	adenosine deaminase-like	153					adenosine catabolic process|inosine biosynthetic process|purine ribonucleoside monophosphate biosynthetic process		adenosine deaminase activity|metal ion binding			endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)	7		all_cancers(109;7.96e-11)|all_epithelial(112;2.96e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;9.31e-07)		GAGGTGGCCCTTTAGTAGCCAA	0.411													10	88	---	---	---	---					
BPI	671	broad.mit.edu	37	20	36932652	36932652	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:36932652delG	ENST00000262865.4	+	1	128	c.39delG	c.(37-39)ccfs	p.P13fs	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	13					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding	p.P13P(1)		kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				GCAACGCGCCGAGATGGGCGT	0.617													16	116	---	---	---	---					
BMP7	655	broad.mit.edu	37	20	55777651	55777651	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chr20:55777651delG	ENST00000395863.3	-	3	1145	c.640delC	c.(640-642)gtfs	p.R214fs	BMP7_ENST00000450594.2_Frame_Shift_Del_p.R214fs|BMP7_ENST00000460817.1_5'UTR|BMP7_ENST00000395864.3_Frame_Shift_Del_p.R214fs	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7	214					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			CAGAGGGTACGGCTGTCGAGC	0.617													14	56	---	---	---	---					
TSIX	9383	broad.mit.edu	37	X	73044420	73044420	+	RNA	DEL	G	G	-			TCGA-64-1679-01A-21D-2063-08	TCGA-64-1679-10A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	529d953a-880b-4dd4-a6aa-c09c8c89d980	510b548e-4350-45c8-889d-8930c2f20f9c	g.chrX:73044420delG	ENST00000604411.1	+	0	32381				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TTCTCACTGTGGTTTAACTAT	0.299													10	17	---	---	---	---					
