Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C1orf198	84886	broad.mit.edu	37	1	230979457	230979457	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:230979457G>C	ENST00000366663.5	-	3	710	c.570C>G	c.(568-570)ttC>ttG	p.F190L	C1orf198_ENST00000470540.1_Missense_Mutation_p.F152L|C1orf198_ENST00000427697.2_5'UTR|C1orf198_ENST00000523410.1_Missense_Mutation_p.F60L	NM_032800.2	NP_116189.1	Q9H425	CA198_HUMAN	chromosome 1 open reading frame 198	190								p.F190L(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	17	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				TGATCTTCCAGAATGACGCTT	0.637000													5	98					0	0	0.184627	0	0
PRSS21	10942	broad.mit.edu	37	16	2868692	2868692	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:2868692G>C	ENST00000455114.1	+	4	372	c.266G>C	c.(265-267)aGt>aCt	p.S89T	PRSS21_ENST00000005995.3_Missense_Mutation_p.S91T|PRSS21_ENST00000450020.3_Missense_Mutation_p.S91T	NM_001270452.1|NM_006799.3|NM_144956.2	NP_001257381.1|NP_006790.1|NP_659205.1	Q9Y6M0	TEST_HUMAN	protease, serine, 21 (testisin)	91	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity	p.S91T(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	15						AGTGACCTTAGTGATCCCTCC	0.567000													16	49					0	0	0.520397	0	0
OR1N1	138883	broad.mit.edu	37	9	125288842	125288842	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:125288842C>A	ENST00000304880.2	-	1	730	c.731G>T	c.(730-732)tGc>tTc	p.C244F		NM_012363.1	NP_036495.1	Q8NGS0	OR1N1_HUMAN	olfactory receptor, family 1, subfamily N, member 1	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C244F(1)		breast(2)|central_nervous_system(1)|large_intestine(2)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						ACAAACAACGCAGAGGTGGGA	0.552000													13	25					3.27435e-08	4.34572e-08	0.457914	1	0
SPP2	6694	broad.mit.edu	37	2	234967486	234967486	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:234967486G>T	ENST00000168148.3	+	3	305	c.217G>T	c.(217-219)Gtc>Ttc	p.V73F	SPP2_ENST00000373368.1_Missense_Mutation_p.V73F	NM_006944.2	NP_008875.1	Q13103	SPP24_HUMAN	secreted phosphoprotein 2, 24kDa	73					bone remodeling|skeletal system development	extracellular region	endopeptidase inhibitor activity	p.V73F(1)		breast(1)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	12		Breast(86;0.0109)|Renal(207;0.019)|all_lung(227;0.13)|all_hematologic(139;0.182)		Epithelial(121;5.73e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000166)|Lung(119;0.00539)|LUSC - Lung squamous cell carcinoma(224;0.00846)		GAAGGTTGAGGTCCTAGATGA	0.393000													24	52					6.36457e-07	8.05187e-07	0.667858	1	0
ADAMTSL2	9719	broad.mit.edu	37	9	136405802	136405802	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:136405802C>A	ENST00000393061.3	+	6	1254	c.822C>A	c.(820-822)gcC>gcA	p.A274A	ADAMTSL2_ENST00000393060.1_Silent_p.A165A|ADAMTSL2_ENST00000354484.4_Silent_p.A165A			Q86TH1	ATL2_HUMAN	ADAMTS-like 2	165					negative regulation of transforming growth factor beta receptor signaling pathway	proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding	p.A165A(1)		kidney(2)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(145;9.31e-08)|Epithelial(140;6.62e-07)|all cancers(34;7.74e-06)		TGGTCCCCGCCCGCGACGGCA	0.572000													15	28					9.16793e-09	1.24477e-08	0.520397	1	0
GTSE1	51512	broad.mit.edu	37	22	46704833	46704833	+	Missense_Mutation	SNP	C	C	A	rs147669373	byFrequency	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr22:46704833C>A	ENST00000454366.1	+	4	967	c.755C>A	c.(754-756)gCg>gAg	p.A252E		NM_016426.6	NP_057510.4	Q9NYZ3	GTSE1_HUMAN	G-2 and S-phase expressed 1	233					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G2 phase of mitotic cell cycle|microtubule-based process	cytoplasmic microtubule		p.A252E(1)|p.A233E(1)		NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	27		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00462)		CCTGGGGCTGCGGAGAAGGTA	0.622000													3	32					0.00024832	0.000283732	0.150653	1	0
NUF2	83540	broad.mit.edu	37	1	163313600	163313600	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:163313600G>C	ENST00000271452.3	+	10	1026	c.747G>C	c.(745-747)gaG>gaC	p.E249D	NUF2_ENST00000367900.3_Missense_Mutation_p.E249D|NUF2_ENST00000524800.1_Missense_Mutation_p.E249D	NM_145697.2	NP_663735.2	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	249	Interaction with the N-terminus of NDC80.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding	p.E249D(2)		breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(15)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	all_hematologic(923;0.101)					ATTCTCCAGAGAAGTTAAAGA	0.274000													10	34					0	0	0.387290	0	0
MSANTD1	345222	broad.mit.edu	37	4	3255175	3255175	+	Missense_Mutation	SNP	G	G	T	rs138360402		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:3255175G>T	ENST00000438480.2	+	2	2309	c.562G>T	c.(562-564)Gac>Tac	p.D188Y	MSANTD1_ENST00000507492.1_Missense_Mutation_p.D175Y|MSANTD1_ENST00000510580.1_Missense_Mutation_p.D188Y	NM_001042690.1	NP_001036155.1	Q6ZTZ1	CD044_HUMAN	Myb/SANT-like DNA-binding domain containing 1	188								p.D188Y(2)		endometrium(1)|lung(2)	3						TGATCGCTCCGACAGCTCCTC	0.587000													50	96					4.0181e-32	7.76115e-32	0.870114	1	0
RBFOX1	54715	broad.mit.edu	37	16	7568325	7568325	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:7568325C>A	ENST00000340209.4	+	2	516	c.219C>A	c.(217-219)ccC>ccA	p.P73P	RBFOX1_ENST00000552089.1_Silent_p.P104P|RBFOX1_ENST00000422070.4_Silent_p.P111P|RBFOX1_ENST00000550418.1_Silent_p.P68P|RBFOX1_ENST00000436368.2_Silent_p.P88P|RBFOX1_ENST00000535565.2_Silent_p.P104P|RBFOX1_ENST00000547338.1_Silent_p.P68P|RBFOX1_ENST00000355637.4_Silent_p.P88P|RBFOX1_ENST00000553186.1_Silent_p.P68P|RBFOX1_ENST00000311745.5_Silent_p.P88P|RBFOX1_ENST00000547372.1_Silent_p.P111P			Q9NWB1	RFOX1_HUMAN	RNA binding protein, fox-1 homolog (C. elegans) 1	68					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding	p.P88P(2)|p.P68P(1)		breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|lung(17)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)	55						TGTACCCTCCCGCCCAGACGC	0.642000													54	111					4.33383e-22	8.08235e-22	0.870114	1	0
MAGEC1	9947	broad.mit.edu	37	X	140996099	140996099	+	Missense_Mutation	SNP	C	C	A	rs143297640		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:140996099C>A	ENST00000285879.4	+	4	3195	c.2909C>A	c.(2908-2910)cCt>cAt	p.P970H	MAGEC1_ENST00000406005.2_Missense_Mutation_p.P37H	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	970	MAGE.						protein binding	p.P970H(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGTGGACCCTGATGACTCC	0.478000										HNSCC(15;0.026)			72	54					1.07363e-35	2.08618e-35	0.870114	1	0
LYST	1130	broad.mit.edu	37	1	235969372	235969372	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:235969372G>T	ENST00000389794.3	-	6	3238	c.3064C>A	c.(3064-3066)Cag>Aag	p.Q1022K	LYST_ENST00000536965.1_Missense_Mutation_p.Q1022K|LYST_ENST00000389793.2_Missense_Mutation_p.Q1022K			Q99698	LYST_HUMAN	lysosomal trafficking regulator	1022					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding	p.Q1022K(1)		NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTTAAATCCTGGTTTTCATTT	0.338000													34	69					1.62565e-12	2.51201e-12	0.760397	1	0
STIL	6491	broad.mit.edu	37	1	47746154	47746154	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:47746154G>A	ENST00000360380.3	-	13	2339	c.1976C>T	c.(1975-1977)tCa>tTa	p.S659L	STIL_ENST00000337817.5_Missense_Mutation_p.S659L|STIL_ENST00000396221.2_Missense_Mutation_p.S659L|STIL_ENST00000371877.3_Missense_Mutation_p.S659L|STIL_ENST00000243182.6_Missense_Mutation_p.S659L			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	659	PIN1-binding (By similarity).				cell proliferation|multicellular organismal development	centrosome|cytosol		p.S659L(1)		central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				AGGACTACTTGAAGAACAGAA	0.468000													5	79					0	0	0.184627	0	0
MUC5B	727897	broad.mit.edu	37	11	1272371	1272371	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:1272371C>T	ENST00000447027.1	+	31	14328	c.14270C>T	c.(14269-14271)cCc>cTc	p.P4757L	MUC5B_ENST00000529681.1_Missense_Mutation_p.P4754L			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4754	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding	p.P4709L(1)|p.P4754L(1)		cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACACCCATCCCCTCCTCCACC	0.577000													10	31					0	0	0.361761	0	0
T	6862	broad.mit.edu	37	6	166574331	166574331	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:166574331C>A	ENST00000296946.2	-	8	1496	c.1028G>T	c.(1027-1029)aGc>aTc	p.S343I	T_ENST00000366871.3_Missense_Mutation_p.S285I	NM_003181.3	NP_003172.1	O15178	BRAC_HUMAN	T, brachyury homolog (mouse)	343					anterior/posterior axis specification, embryo|mesoderm development|primitive streak formation	nucleus	sequence-specific DNA binding transcription factor activity	p.S343I(1)		autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Prostate(117;4.48e-07)|Ovarian(120;1.78e-06)|Breast(66;2.54e-06)|Lung SC(201;0.0225)|Esophageal squamous(34;0.0559)		OV - Ovarian serous cystadenocarcinoma(33;1.09e-113)|GBM - Glioblastoma multiforme(31;1.51e-108)|BRCA - Breast invasive adenocarcinoma(81;8.45e-09)|LUAD - Lung adenocarcinoma(999;0.0407)		TTACCTGGAGCTGGTAGGTGG	0.542000									Chordoma, Familial Clustering of				26	43					4.22769e-11	6.35133e-11	0.706142	1	0
NNT	23530	broad.mit.edu	37	5	43656852	43656852	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:43656852G>T	ENST00000264663.5	+	16	2612	c.2391G>T	c.(2389-2391)gtG>gtT	p.V797V	NNT_ENST00000344920.4_Silent_p.V797V|NNT_ENST00000512996.2_Silent_p.V666V	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	797					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding	p.V797V(1)		breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	CATTCATGGTGGACCCAAGCT	0.493000													25	137					6.12954e-19	1.08988e-18	0.681144	1	0
OR10A4	283297	broad.mit.edu	37	11	6898490	6898490	+	Silent	SNP	T	T	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:6898490T>G	ENST00000379829.2	+	1	635	c.612T>G	c.(610-612)acT>acG	p.T204T		NM_207186.2	NP_997069.2	Q9H209	O10A4_HUMAN	olfactory receptor, family 10, subfamily A, member 4	204					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T204T(1)		kidney(1)|large_intestine(2)|liver(2)|lung(20)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	31		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TGACAGCCACTGTCCTATTCA	0.522000													11	53					0	0	0.387290	0	0
SZT2	23334	broad.mit.edu	37	1	43870102	43870102	+	Missense_Mutation	SNP	C	C	T	rs150074610		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:43870102C>T	ENST00000562955.1	+	4	379	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C	SZT2_ENST00000372450.4_Missense_Mutation_p.R125C|SZT2_ENST00000310739.4_Missense_Mutation_p.R127C	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	127						peroxisome		p.R127C(1)|p.R125C(1)		NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						TGCCCTGTCCCGCTGCTTAGG	0.547000													11	55					0	0	0.387290	0	0
ANXA13	312	broad.mit.edu	37	8	124696964	124696964	+	Splice_Site	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:124696964T>C	ENST00000262219.6	-	11	909		c.e11-2		ANXA13_ENST00000419625.1_Splice_Site	NM_001003954.1	NP_001003954.1	P27216	ANX13_HUMAN	annexin A13						cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding	p.?(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	25	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			CACATCTCACTGGGCAGGACA	0.522000													13	30					0	0	0.457914	0	0
ATP1A4	480	broad.mit.edu	37	1	160137163	160137163	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:160137163G>C	ENST00000368081.4	+	10	1923	c.1452G>C	c.(1450-1452)aaG>aaC	p.K484N		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	484					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity	p.K484N(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AAAACCCCAAGGTGGCAGAGA	0.522000													37	81					0	0	0.796494	0	0
TRAK1	22906	broad.mit.edu	37	3	42226214	42226214	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:42226214A>T	ENST00000327628.5	+	4	801	c.401A>T	c.(400-402)cAg>cTg	p.Q134L	TRAK1_ENST00000449246.1_Missense_Mutation_p.Q60L|TRAK1_ENST00000487159.1_3'UTR|TRAK1_ENST00000396175.1_Missense_Mutation_p.Q76L|TRAK1_ENST00000341421.3_Missense_Mutation_p.Q76L	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	134	HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus		p.Q76L(2)|p.Q134L(1)		central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						CGCATCGGCCAGTCGTTGTTG	0.512000													39	78					0	0	0.812448	0	0
OSBPL7	114881	broad.mit.edu	37	17	45895647	45895647	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:45895647G>A	ENST00000007414.3	-	7	777	c.586C>T	c.(586-588)Cgc>Tgc	p.R196C	OSBPL7_ENST00000392507.3_Missense_Mutation_p.R196C	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	196					lipid transport		lipid binding	p.R196C(1)		autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						TGAGAGCAGCGGTCCAGCCCA	0.622000													16	51					0	0	0.539581	0	0
XDH	7498	broad.mit.edu	37	2	31609340	31609340	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:31609340G>T	ENST00000379416.3	-	9	781	c.733C>A	c.(733-735)Ctg>Atg	p.L245M	XDH_ENST00000491727.1_5'UTR	NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	245	FAD-binding PCMH-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity	p.L245M(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	AGGTCCAGCAGCTCCTTGAGG	0.607000													19	38					1.33834e-09	1.89646e-09	0.557998	1	0
BST1	683	broad.mit.edu	37	4	15724522	15724522	+	Silent	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:15724522G>C	ENST00000382346.3	+	9	910	c.861G>C	c.(859-861)gtG>gtC	p.V287V	BST1_ENST00000265016.4_Silent_p.V272V			Q10588	BST1_HUMAN	bone marrow stromal cell antigen 1	272					humoral immune response|multicellular organismal development	anchored to membrane|extrinsic to membrane|plasma membrane	binding|NAD+ nucleosidase activity	p.V272V(1)		central_nervous_system(1)|large_intestine(1)|lung(2)|stomach(3)|urinary_tract(1)	8						TACAGTGCGTGGACCACAGCA	0.373000													17	61					0	0	0.557998	0	0
RNASE3	6037	broad.mit.edu	37	14	21359949	21359949	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:21359949C>A	ENST00000304639.3	+	2	162	c.104C>A	c.(103-105)gCt>gAt	p.A35D		NM_002935.2	NP_002926.2	P12724	ECP_HUMAN	ribonuclease, RNase A family, 3	35					defense response to bacterium|RNA catabolic process	extracellular region|soluble fraction	nucleic acid binding|pancreatic ribonuclease activity	p.A35D(1)		endometrium(1)|large_intestine(1)|lung(6)|ovary(1)	9	all_cancers(95;0.00453)		OV - Ovarian serous cystadenocarcinoma(11;6.3e-09)|Epithelial(56;1.42e-07)|all cancers(55;5.48e-07)	GBM - Glioblastoma multiforme(265;0.0187)	Pranlukast(DB01411)	TTTACGAGGGCTCAGTGGTTT	0.498000													31	60					5.91797e-21	1.07887e-20	0.760397	1	0
TRPM4	54795	broad.mit.edu	37	19	49693476	49693476	+	Silent	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:49693476A>C	ENST00000252826.5	+	15	2157	c.2031A>C	c.(2029-2031)acA>acC	p.T677T	TRPM4_ENST00000427978.2_Silent_p.T677T|TRPM4_ENST00000355712.5_Silent_p.T323T	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	677					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding	p.T677T(1)		breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CTCTGCTGACACAGAAGTGGT	0.587000													125	106					0	0	0.870114	0	0
TRIM25	7706	broad.mit.edu	37	17	54969341	54969341	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:54969341G>A	ENST00000316881.4	-	9	1662	c.1613C>T	c.(1612-1614)cCa>cTa	p.P538L	TRIM25_ENST00000537230.1_Missense_Mutation_p.P538L	NM_005082.4	NP_005073.2	Q14258	TRI25_HUMAN	tripartite motif containing 25	538	B30.2/SPRY.				innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|response to virus	cell junction|cytosol|nucleus	sequence-specific DNA binding transcription factor activity|ubiquitin-protein ligase activity|zinc ion binding	p.P538L(1)		breast(2)|endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Breast(9;6.15e-08)					CCTGCTTTCTGGGCCCTGCCG	0.582000													30	75					0	0	0.760397	0	0
TAF1L	138474	broad.mit.edu	37	9	32630549	32630549	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:32630549T>C	ENST00000242310.4	-	1	5118	c.5029A>G	c.(5029-5031)Acg>Gcg	p.T1677A		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1677					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.T1677A(1)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCTCGAGACGTACTGAGGGAT	0.483000													61	125					0	0	0.870114	0	0
PLCE1	51196	broad.mit.edu	37	10	95791904	95791904	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:95791904G>T	ENST00000260766.3	+	2	1735	c.1101G>T	c.(1099-1101)aaG>aaT	p.K367N	PLCE1_ENST00000371380.2_Missense_Mutation_p.K367N	NM_016341.3	NP_057425.3	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1	367					activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity	p.K367N(1)		liver(1)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	8		Colorectal(252;0.0458)				TAGATCAGAAGAGAAATGGTC	0.483000													17	31					1.5739e-10	2.31623e-10	0.500413	1	0
RHCE	6006	broad.mit.edu	37	1	25717390	25717390	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:25717390C>A	ENST00000349320.3	-	7	991	c.603G>T	c.(601-603)tgG>tgT	p.W201C	RHCE_ENST00000413854.1_Missense_Mutation_p.W217C|RHCE_ENST00000294413.7_Missense_Mutation_p.W217C|RHCE_ENST00000340849.4_Intron|RHCE_ENST00000425135.1_Missense_Mutation_p.W217C|RHCE_ENST00000349438.4_Missense_Mutation_p.W217C|RHCE_ENST00000455194.1_Intron|RHCE_ENST00000346452.4_Intron|RHCE_ENST00000374352.2_Missense_Mutation_p.W201C|RHCE_ENST00000243186.6_Missense_Mutation_p.W217C			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	217				R -> T (in Ref. 13; ACK75568).		integral to plasma membrane		p.W217C(1)		endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		GCCAGAACATCCACAAGAAGA	0.527000													17	93					9.16793e-09	1.24477e-08	0.520397	1	0
HAUS5	23354	broad.mit.edu	37	19	36109807	36109807	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:36109807G>T	ENST00000203166.5	+	13	1060	c.1035G>T	c.(1033-1035)ggG>ggT	p.G345G	HAUS5_ENST00000379045.2_3'UTR	NM_015302.1	NP_056117.1	O94927	HAUS5_HUMAN	HAUS augmin-like complex, subunit 5	345					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle		p.G345G(1)		NS(1)|breast(2)|cervix(3)|endometrium(1)|large_intestine(2)|lung(5)|skin(2)	16						TGATACTGGGGCTTCGGCGCT	0.617000													31	42					2.80507e-11	4.2337e-11	0.760397	1	0
ZFHX4	79776	broad.mit.edu	37	8	77764145	77764145	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:77764145C>A	ENST00000521891.2	+	10	5436	c.4988C>A	c.(4987-4989)aCc>aAc	p.T1663N	ZFHX4_ENST00000518282.1_Missense_Mutation_p.T1637N|ZFHX4_ENST00000050961.6_Missense_Mutation_p.T1618N|ZFHX4_ENST00000455469.2_Missense_Mutation_p.T1618N	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1618	Gln-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.T1663N(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGCAAAGATACCCATTTAGAT	0.453000										HNSCC(33;0.089)			11	43					2.27111e-07	2.91871e-07	0.411799	1	0
IQSEC3	440073	broad.mit.edu	37	12	176419	176419	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:176419C>T	ENST00000538872.1	+	1	489	c.371C>T	c.(370-372)cCc>cTc	p.P124L	IQSEC3_ENST00000326261.4_Missense_Mutation_p.P124L			Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	124					regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity	p.P124L(1)		central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		CTGGAGCAGCCCCAGCGGGGC	0.711000													3	7					0	0	0.115264	0	0
IGF2BP3	10643	broad.mit.edu	37	7	23358857	23358857	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:23358857G>C	ENST00000258729.3	-	11	1576	c.1220C>G	c.(1219-1221)aCt>aGt	p.T407S		NM_006547.2	NP_006538.2	O00425	IF2B3_HUMAN	insulin-like growth factor 2 mRNA binding protein 3	407	KH 3.				anatomical structure morphogenesis|negative regulation of translation|translation	cytosol|nucleus	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity	p.T407S(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(2)|prostate(2)|skin(4)|stomach(1)	34						CAGATGAACAGTCTCCGTTTC	0.448000													30	65					0	0	0.740014	0	0
NBPF10	100132406	broad.mit.edu	37	1	145304535	145304535	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:145304535G>C	ENST00000342960.5	+	10	1503	c.1468G>C	c.(1468-1470)Gac>Cac	p.D490H	NBPF10_ENST00000369338.1_Missense_Mutation_p.D219H|NBPF10_ENST00000369339.2_Missense_Mutation_p.D219H|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	490								p.D219H(1)|p.D490H(1)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TGGCTCTTATGACTCCAACCA	0.468000													6	421					0	0	0.248553	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	11					0.00307968	0.00333119	0.278610	1	0
CTNND2	1501	broad.mit.edu	37	5	11346577	11346577	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:11346577A>T	ENST00000304623.8	-	9	1724	c.1535T>A	c.(1534-1536)gTt>gAt	p.V512D	CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.V512D|CTNND2_ENST00000458100.2_Missense_Mutation_p.V79D|CTNND2_ENST00000511377.1_Missense_Mutation_p.V421D|CTNND2_ENST00000503622.1_Missense_Mutation_p.V175D	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	512					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding	p.V512D(1)		NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TGGAGACTCAACAGAGGGACA	0.612000													29	145					0	0	0.706142	0	0
RIPPLY2	134701	broad.mit.edu	37	6	84567041	84567041	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:84567041C>A	ENST00000369689.1	+	4	471	c.320C>A	c.(319-321)gCc>gAc	p.A107D	RIPPLY2_ENST00000369687.1_Missense_Mutation_p.A49D	NM_001009994.1	NP_001009994.1	Q5TAB7	RIPP2_HUMAN	ripply transcriptional repressor 2	107	Ripply homology domain.				somite rostral/caudal axis specification	nucleus		p.A107D(1)		large_intestine(2)|lung(4)|urinary_tract(1)	7						CCAATTCAAGCCACAATTTCA	0.313000													29	59					5.61819e-17	9.67163e-17	0.693898	1	0
COL24A1	255631	broad.mit.edu	37	1	86590978	86590978	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:86590978G>A	ENST00000370571.2	-	3	1407	c.1041C>T	c.(1039-1041)ttC>ttT	p.F347F	COL24A1_ENST00000436319.1_Silent_p.F347F	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	347					cell adhesion	collagen	extracellular matrix structural constituent	p.F347F(1)		NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTGACAGGCTGAAATTTGTCT	0.413000													16	67					0	0	0.520397	0	0
FOXG1	2290	broad.mit.edu	37	14	29237064	29237064	+	Silent	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:29237064C>G	ENST00000382535.3	+	2	948	c.579C>G	c.(577-579)gcC>gcG	p.A193A	FOXG1_ENST00000313071.4_Silent_p.A193A			P55316	FOXG1_HUMAN	forkhead box G1	193					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.A193A(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		TCATGATGGCCATCCGGCAGA	0.607000													11	22					0	0	0.411799	0	0
WDR90	197335	broad.mit.edu	37	16	712767	712767	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:712767A>T	ENST00000549091.1	+	34	4332	c.4240A>T	c.(4240-4242)Acc>Tcc	p.T1414S	WDR90_ENST00000293879.4_Missense_Mutation_p.T1412S	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1412								p.T1412S(1)		endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				CGTCGTGGGCACCACGGCGGG	0.637000													7	17					0	0	0.248553	0	0
TRIM33	51592	broad.mit.edu	37	1	114969832	114969832	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:114969832G>A	ENST00000358465.2	-	8	1470	c.1387C>T	c.(1387-1389)Ccc>Tcc	p.P463S	TRIM33_ENST00000369543.2_Missense_Mutation_p.P463S|TRIM33_ENST00000450349.2_Missense_Mutation_p.P71S	NM_015906.3	NP_056990.3	Q9UPN9	TRI33_HUMAN	tripartite motif containing 33	463					negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding	p.P463S(1)		breast(2)|central_nervous_system(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	48	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CAGAAGGTGGGATCACAATGG	0.368000			T	RET	papillary thyroid								13	51					0	0	0.435327	0	0
MARCO	8685	broad.mit.edu	37	2	119727764	119727764	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:119727764C>A	ENST00000541757.1	+	4	420	c.40C>A	c.(40-42)Ccg>Acg	p.P14T	MARCO_ENST00000327097.4_Missense_Mutation_p.P92T			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	92					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity	p.P92K(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						TGAGGACAGCCCGTCCTTCTC	0.612000													12	40					1.5842e-08	2.13752e-08	0.435327	1	0
VSTM2A	222008	broad.mit.edu	37	7	54617553	54617553	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:54617553C>A	ENST00000302287.3	+	4	730	c.324C>A	c.(322-324)atC>atA	p.I108I	VSTM2A_ENST00000407838.3_Silent_p.I108I|VSTM2A_ENST00000402026.2_Silent_p.I107I|VSTM2A_ENST00000402613.3_Silent_p.I108I|VSTM2A_ENST00000404951.1_Silent_p.I108I|VSTM2A_ENST00000498834.1_3'UTR			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	108	Ig-like V-type.					extracellular region		p.I107I(2)|p.I108I(1)		endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			GCAATGACATCTCCCACAAGC	0.408000													3	14					0.150653	0.153011	0.150653	1	0
WDR96	80217	broad.mit.edu	37	10	105902094	105902094	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:105902094C>T	ENST00000357060.3	-	33	4331	c.4216G>A	c.(4216-4218)Gag>Aag	p.E1406K	WDR96_ENST00000428666.1_Missense_Mutation_p.E1378K	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1406								p.E1406K(1)		NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCTTCCTCCTCAACTCTCTTC	0.403000													10	68					0	0	0.335167	0	0
GDF6	392255	broad.mit.edu	37	8	97172755	97172755	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:97172755G>A	ENST00000287020.5	-	1	265	c.166C>T	c.(166-168)Cgc>Tgc	p.R56C		NM_001001557.2	NP_001001557.1	Q6KF10	GDF6_HUMAN	growth differentiation factor 6	56					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity	p.R56C(1)		breast(2)|cervix(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	27	Breast(36;2.67e-05)					TCACTGTCGCGCGGCGCCCGC	0.711000													32	50					0	0	0.796494	0	0
CYP2A7	1549	broad.mit.edu	37	19	41387975	41387975	+	Silent	SNP	G	G	T	rs150838585	by1000genomes	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:41387975G>T	ENST00000301146.4	-	1	682	c.141C>A	c.(139-141)ctC>ctA	p.L47L	CYP2A7_ENST00000291764.3_Silent_p.L47L|CTC-490E21.12_ENST00000601627.1_Intron	NM_000764.2	NP_000755.2	P20853	CP2A7_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 7	47						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding	p.L47L(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			TGTTCAGCTGGAGGTAGTTTC	0.582000													5	49					0.014758	0.0154483	0.184627	1	0
FAM27L	284123	broad.mit.edu	37	17	21826375	21826375	+	RNA	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:21826375G>T	ENST00000426869.3	+	0	558					NR_028336.1				family with sequence similarity 27-like											central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14				UCEC - Uterine corpus endometrioid carcinoma (53;0.11)|BRCA - Breast invasive adenocarcinoma(1;0.00463)		CTGGGCTCTGGCCCCTGCTCT	0.557000													5	7					1.23904e-05	1.48639e-05	0.184627	1	0
IL20RA	53832	broad.mit.edu	37	6	137325893	137325893	+	Silent	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:137325893T>C	ENST00000367748.1	-	5	982	c.396A>G	c.(394-396)caA>caG	p.Q132Q	IL20RA_ENST00000541547.1_Silent_p.Q194Q|IL20RA_ENST00000468393.1_5'UTR|IL20RA_ENST00000316649.5_Silent_p.Q243Q			Q9UHF4	I20RA_HUMAN	interleukin 20 receptor, alpha	243	Fibronectin type-III 1.					integral to membrane	receptor activity	p.Q243Q(1)		NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	27	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000351)|OV - Ovarian serous cystadenocarcinoma(155;0.00459)		ACTCTGATGATTGATCTGTAA	0.378000													20	68					0	0	0.624587	0	0
MUC16	94025	broad.mit.edu	37	19	9047816	9047816	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:9047816T>A	ENST00000397910.4	-	5	34018	c.33815A>T	c.(33814-33816)gAg>gTg	p.E11272V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11274	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.E6905V(1)|p.E11272V(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGAGCTACTCTCTGCAGGATG	0.488000													8	8					0	0	0.278610	0	0
CHL1	10752	broad.mit.edu	37	3	440756	440756	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:440756T>A	ENST00000256509.2	+	26	3952	c.3310T>A	c.(3310-3312)Tgt>Agt	p.C1104S	CHL1_ENST00000397491.2_Missense_Mutation_p.C1088S	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	1088					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix		p.C1104S(1)		NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TGGACTGATGTGTGCGATTGC	0.368000													32	93					0	0	0.769981	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140723759	140723759	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:140723759G>A	ENST00000253812.6	+	1	159	c.159G>A	c.(157-159)ggG>ggA	p.G53G	PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1												p.G53G(1)		breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGACCTGGGGCTAGAGCCCC	0.607000											OREG0016855	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	116					0	0	0.847076	0	0
LCORL	254251	broad.mit.edu	37	4	17910869	17910869	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:17910869C>A	ENST00000382226.5	-	5	638	c.530G>T	c.(529-531)gGt>gTt	p.G177V	LCORL_ENST00000382224.1_Missense_Mutation_p.G93V|LCORL_ENST00000326877.3_Missense_Mutation_p.G177V|LCORL_ENST00000539056.1_Missense_Mutation_p.G90V	NM_001166139.1	NP_001159611.1	Q8N3X6	LCORL_HUMAN	ligand dependent nuclear receptor corepressor-like	177					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.G177V(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)	4						TTGAGTTTTACCACTTTTTGA	0.363000													19	55					2.39187e-15	4.01737e-15	0.575678	1	0
CSF2RB	1439	broad.mit.edu	37	22	37333941	37333941	+	Missense_Mutation	SNP	G	G	A	rs138676111		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr22:37333941G>A	ENST00000262825.5	+	14	2326	c.2109G>A	c.(2107-2109)atG>atA	p.M703I	CSF2RB_ENST00000403662.3_Missense_Mutation_p.M697I|CSF2RB_ENST00000406230.1_Missense_Mutation_p.M703I|CSF2RB_ENST00000536485.1_Missense_Mutation_p.M644I	NM_000395.2	NP_000386.1	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	697					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity	p.M697I(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(18)|ovary(3)|pancreas(1)|skin(5)|upper_aerodigestive_tract(2)	42					Sargramostim(DB00020)	CTATACCCATGAGCTCTGGGG	0.627000													12	27					0	0	0.387290	0	0
PCSK5	5125	broad.mit.edu	37	9	78710935	78710935	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:78710935G>C	ENST00000545128.1	+	8	1562	c.1024G>C	c.(1024-1026)Gga>Cga	p.G342R	PCSK5_ENST00000376752.4_Missense_Mutation_p.G342R|PCSK5_ENST00000376767.3_Missense_Mutation_p.G342R	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	342	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity	p.G342R(3)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						TGCAGAAAGCGGAAAGAAACC	0.512000													8	50					0	0	0.278610	0	0
FBN3	84467	broad.mit.edu	37	19	8152944	8152944	+	Splice_Site	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:8152944C>A	ENST00000600128.1	-	52	6910	c.6496_splice	c.e52+1	p.D2166_splice	FBN3_ENST00000270509.2_Splice_Site_p.D2166_splice|FBN3_ENST00000601739.1_Splice_Site_p.D2166_splice			Q75N90	FBN3_HUMAN	fibrillin 3	2166	EGF-like 35; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent	p.D2166Y(1)		NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AGAGTTGTACCCTCGCAGGTC	0.642000													13	23					2.27111e-07	2.91871e-07	0.411799	1	0
WBSCR17	64409	broad.mit.edu	37	7	70880937	70880937	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:70880937G>T	ENST00000333538.5	+	4	1286	c.652G>T	c.(652-654)Gta>Tta	p.V218L	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	218	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.V218L(1)		NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGTGAAGGTGGTAAGAAATCA	0.532000													11	26					7.03913e-09	9.69935e-09	0.411799	1	0
CD5L	922	broad.mit.edu	37	1	157805829	157805829	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:157805829C>A	ENST00000368174.4	-	3	268	c.172G>T	c.(172-174)Gtg>Ttg	p.V58L	CD5L_ENST00000484609.1_5'UTR	NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	58	SRCR 1.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity	p.V58L(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AACACAGCCACGTCCTTAATG	0.607000													52	109					6.4308e-24	1.21679e-23	0.870114	1	0
TAAR2	9287	broad.mit.edu	37	6	132938666	132938666	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:132938666C>A	ENST00000275191.2	-	1	651	c.544G>T	c.(544-546)Ggg>Tgg	p.G182W	TAAR2_ENST00000367931.1_Missense_Mutation_p.G227W|TAAR2_ENST00000537809.1_Missense_Mutation_p.G182W	NM_014626.3	NP_055441.2	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2	227						plasma membrane	G-protein coupled receptor activity	p.G227W(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)	23	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		CCATAAATCCCCACCATCATA	0.418000													13	43					6.31663e-08	8.29856e-08	0.479597	1	0
EHD1	10938	broad.mit.edu	37	11	64622062	64622062	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:64622062C>T	ENST00000320631.3	-	5	1602	c.1348G>A	c.(1348-1350)Gag>Aag	p.E450K	EHD1_ENST00000359393.2_Missense_Mutation_p.E450K|EHD1_ENST00000488711.1_5'UTR	NM_006795.2	NP_006786.2	Q9H4M9	EHD1_HUMAN	EH-domain containing 1	450	EH.				blood coagulation|cholesterol homeostasis|endocytic recycling|intracellular protein transport|low-density lipoprotein particle clearance|positive regulation of cholesterol storage|protein homooligomerization	early endosome membrane|lipid particle|plasma membrane|platelet dense tubular network membrane|recycling endosome membrane	ATP binding|calcium ion binding|GTP binding|GTPase activity|protein binding	p.E450K(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(3)|ovary(1)|prostate(1)	12						TAGAAGATCTCGTCGTAGGTG	0.637000													19	32					0	0	0.592651	0	0
PRPF40B	25766	broad.mit.edu	37	12	50037160	50037160	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:50037160C>T	ENST00000261897.1	+	22	2809	c.2258C>T	c.(2257-2259)tCc>tTc	p.S753F	FMNL3_ENST00000335154.5_3'UTR|PRPF40B_ENST00000548825.2_Missense_Mutation_p.S787F|PRPF40B_ENST00000380281.1_Missense_Mutation_p.S766F			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	766					mRNA processing|RNA splicing	nuclear speck		p.S766F(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						GGCTCCCCTTCCTCCCATCTT	0.592000													30	38					0	0	0.740014	0	0
TSEN34	79042	broad.mit.edu	37	19	54697134	54697134	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:54697134G>T	ENST00000396383.1	+	5	1161	c.850G>T	c.(850-852)Gtc>Ttc	p.V284F	TSEN34_ENST00000302937.4_Missense_Mutation_p.V284F|TSEN34_ENST00000396388.2_Missense_Mutation_p.V284F|TSEN34_ENST00000429671.2_Missense_Mutation_p.V284F			Q9BSV6	SEN34_HUMAN	TSEN34 tRNA splicing endonuclease subunit	284					mRNA processing|tRNA-type intron splice site recognition and cleavage	nucleolus|tRNA-intron endonuclease complex	nucleic acid binding|tRNA-intron endonuclease activity	p.V284F(1)		endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	10	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGGAACCAGCGTCAGAAAGAC	0.617000													3	69					0.004672	0.00501178	0.115264	1	0
TTC3	7267	broad.mit.edu	37	21	38507791	38507791	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:38507791G>T	ENST00000399017.2	+	18	4302	c.1555G>T	c.(1555-1557)Ggt>Tgt	p.G519C	TTC3_ENST00000354749.2_Missense_Mutation_p.G519C|TTC3_ENST00000355666.1_Missense_Mutation_p.G519C|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000540756.1_Missense_Mutation_p.G209C	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	519					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.G519C(1)		breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				GTTGCTGAACGGTTTAGATCC	0.403000													14	23					2.31682e-05	2.75388e-05	0.479597	1	0
DACH2	117154	broad.mit.edu	37	X	85950089	85950089	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:85950089C>A	ENST00000373131.1	+	4	962	c.799C>A	c.(799-801)Cat>Aat	p.H267N	DACH2_ENST00000508860.1_Missense_Mutation_p.H113N|DACH2_ENST00000373125.4_Missense_Mutation_p.H280N|DACH2_ENST00000510272.1_Missense_Mutation_p.H61N	NM_001139514.1	NP_001132986.1	Q96NX9	DACH2_HUMAN	dachshund homolog 2 (Drosophila)	280					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|nucleotide binding	p.H267N(1)|p.H280N(1)		breast(2)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(14)|lung(28)|ovary(5)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	71						TGGACCCCAACATGGAATTGC	0.468000													11	5					0.000151284	0.000176272	0.435327	1	0
SLCO1C1	53919	broad.mit.edu	37	12	20896250	20896250	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:20896250C>A	ENST00000381552.1	+	13	2113	c.1745C>A	c.(1744-1746)cCa>cAa	p.P582Q	SLCO1C1_ENST00000540354.1_Missense_Mutation_p.P533Q|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.P464Q|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.P582Q|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.P582Q			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	582					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity	p.P582Q(2)		NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TGCATTAAGCCACAGCTTAAG	0.323000													47	72					1.61004e-24	3.05531e-24	0.870114	1	0
GNAS	2778	broad.mit.edu	37	20	57430039	57430039	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:57430039C>T	ENST00000306120.3	+	1	1529	c.1529C>T	c.(1528-1530)aCg>aTg	p.T510M	GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371099.2_Silent_p.D573D|GNAS_ENST00000371100.4_Silent_p.D573D|GNAS_ENST00000371102.4_Silent_p.D573D|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000603534.1_Intron|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371075.3_Intron			P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity	p.D573D(1)		adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			CCAGCAGCGACGATGACTCCA	0.687000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			6	13					0	0	0.248553	0	0
TAS2R1	50834	broad.mit.edu	37	5	9629469	9629469	+	Missense_Mutation	SNP	C	C	A	rs145804099		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:9629469C>A	ENST00000382492.2	-	1	994	c.676G>T	c.(676-678)Gcg>Tcg	p.A226S	CTD-2001E22.1_ENST00000504182.2_RNA	NM_019599.2	NP_062545.1	Q9NYW7	TA2R1_HUMAN	taste receptor, type 2, member 1	226					chemosensory behavior|sensory perception of taste	integral to membrane	taste receptor activity	p.A226S(1)		breast(5)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(19)|ovary(3)|prostate(1)|skin(1)|stomach(1)	39						GACAGCAACGCGCTGATGGGT	0.498000													36	38					9.80977e-26	1.87804e-25	0.796494	1	0
PTPRZ1	5803	broad.mit.edu	37	7	121652034	121652034	+	Silent	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:121652034C>G	ENST00000393386.2	+	12	3345	c.2934C>G	c.(2932-2934)acC>acG	p.T978T	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	978					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity	p.T978T(2)		NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CGTTAATAACCCCAACTGCAT	0.453000													44	89					0	0	0.870114	0	0
ATRN	8455	broad.mit.edu	37	20	3584857	3584857	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:3584857A>G	ENST00000262919.5	+	24	3817	c.3749A>G	c.(3748-3750)aAt>aGt	p.N1250S	ATRN_ENST00000446916.2_Missense_Mutation_p.N1250S	NM_139321.2	NP_647537.1	O75882	ATRN_HUMAN	attractin	1250					inflammatory response	extracellular space|integral to plasma membrane	receptor activity|sugar binding	p.N1250S(1)		breast(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	59						AACCACCCAAATATCACTTTC	0.393000													14	54					0	0	0.457914	0	0
HUWE1	10075	broad.mit.edu	37	X	53642720	53642720	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:53642720C>A	ENST00000342160.3	-	21	2491	c.2034G>T	c.(2032-2034)acG>acT	p.T678T	HUWE1_ENST00000262854.6_Silent_p.T678T|HUWE1_ENST00000218328.8_Silent_p.T678T			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	678					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity	p.T678T(2)		NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TGATGGCAGTCGTTGCATCTG	0.458000													13	6					4.36969e-10	6.28809e-10	0.435327	1	0
SLITRK3	22865	broad.mit.edu	37	3	164908507	164908507	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:164908507C>G	ENST00000475390.1	-	2	555	c.112G>C	c.(112-114)Gag>Cag	p.E38Q	SLITRK3_ENST00000241274.3_Missense_Mutation_p.E38Q			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	38						integral to membrane		p.E38Q(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						TCTATTTCCTCTGAGTCCTCT	0.398000										HNSCC(40;0.11)			18	59					0	0	0.592651	0	0
EBF1	1879	broad.mit.edu	37	5	158139237	158139237	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:158139237C>A	ENST00000313708.6	-	14	1756	c.1474G>T	c.(1474-1476)Ggc>Tgc	p.G492C	EBF1_ENST00000380654.4_Missense_Mutation_p.G461C|EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Intron	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	492	Pro/Ser/Thr-rich.				multicellular organismal development	nucleus	DNA binding|metal ion binding	p.G492C(1)	HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GCGGCAGAGCCGTATCCGTTC	0.582000			T	HMGA2	lipoma								6	12					2.0095e-06	2.48886e-06	0.248553	1	0
PRSS58	136541	broad.mit.edu	37	7	141955399	141955399	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:141955399C>T	ENST00000552471.1	-	2	454	c.135G>A	c.(133-135)ctG>ctA	p.L45L	PRSS58_ENST00000547058.2_Silent_p.L45L			Q8IYP2	PRS58_HUMAN	protease, serine, 58	45	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.L45L(1)		kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						GCGGGTGGATCAGGACTCCAG	0.498000													11	37					0	0	0.361761	0	0
TRHDE	29953	broad.mit.edu	37	12	73056892	73056892	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:73056892G>C	ENST00000261180.4	+	19	3088	c.2992G>C	c.(2992-2994)Gaa>Caa	p.E998Q		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	998					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding	p.E998Q(1)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						ACGAGCTGTGGAAACTGTCGA	0.388000													19	18					0	0	0.575678	0	0
DNAI2	64446	broad.mit.edu	37	17	72277987	72277987	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:72277987C>A	ENST00000579490.1	+	1	337	c.202C>A	c.(202-204)Cgc>Agc	p.R68S	DNAI2_ENST00000307504.5_5'UTR|DNAI2_ENST00000582036.1_Missense_Mutation_p.R11S|DNAI2_ENST00000311014.6_Missense_Mutation_p.R11S|DNAI2_ENST00000446837.2_Missense_Mutation_p.R11S			Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate chain 2	11					cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity	p.R11S(1)		breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(2)|lung(19)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						CGTCAAGAAGCGCAGCGAGTT	0.632000									Kartagener syndrome				18	42					1.45105e-14	2.38413e-14	0.539581	1	0
RGS22	26166	broad.mit.edu	37	8	101051226	101051226	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:101051226A>C	ENST00000360863.6	-	14	2293	c.2099T>G	c.(2098-2100)cTg>cGg	p.L700R	RGS22_ENST00000523437.1_Missense_Mutation_p.L688R|RGS22_ENST00000523287.1_Missense_Mutation_p.L519R	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	700					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity	p.L700R(2)	RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			ATAAGCCTGCAGGTCAAACCA	0.348000													10	35					0	0	0.335167	0	0
IL22RA1	58985	broad.mit.edu	37	1	24463712	24463712	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:24463712G>A	ENST00000270800.1	-	3	302	c.264C>T	c.(262-264)ctC>ctT	p.L88L		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	88	Fibronectin type-III 1.					integral to membrane	interferon receptor activity	p.L88L(1)		breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		AGAGCTCCGTGAGGTTGCCCG	0.612000													7	35					0	0	0.278610	0	0
PMCHL2	5370	broad.mit.edu	37	5	70672131	70672131	+	RNA	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:70672131G>T	ENST00000502659.2	-	0	698				PMCHL2_ENST00000450213.2_RNA																							ATGTATGCTGGGAAGAGTCTA	0.328000													3	30					4.3838e-07	5.56768e-07	0.435327	1	0
LMX1B	4010	broad.mit.edu	37	9	129376847	129376847	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:129376847C>A	ENST00000355497.5	+	1	126	c.119C>A	c.(118-120)gCc>gAc	p.A40D	LMX1B_ENST00000425646.2_Missense_Mutation_p.A17D|LMX1B_ENST00000373474.4_Missense_Mutation_p.A40D|LMX1B_ENST00000561065.1_Missense_Mutation_p.A17D|LMX1B_ENST00000526117.1_Missense_Mutation_p.A40D	NM_001174146.1	NP_001167617.1	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	17	LIM zinc-binding 1.				dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A40D(1)|p.A17D(1)		endometrium(1)|large_intestine(3)|lung(9)|ovary(1)|skin(1)	15						CCCGGGCCCGCCACTCTGGGG	0.716000									Nail-Patella Syndrome				4	3					0.00909568	0.00961416	0.150653	1	0
SKA1	220134	broad.mit.edu	37	18	47908532	47908532	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr18:47908532G>T	ENST00000285116.3	+	4	458	c.247G>T	c.(247-249)Gac>Tac	p.D83Y	SKA1_ENST00000488454.1_5'UTR|SKA1_ENST00000417656.2_Missense_Mutation_p.D83Y|SKA1_ENST00000398452.2_Missense_Mutation_p.D83Y	NM_001039535.2|NM_145060.3	NP_001034624.1|NP_659497.1	Q96BD8	SKA1_HUMAN	spindle and kinetochore associated complex subunit 1	83					cell division|chromosome segregation|mitotic anaphase|mitotic prometaphase|regulation of microtubule polymerization or depolymerization	condensed chromosome outer kinetochore|cytosol|spindle microtubule	microtubule binding	p.D83Y(1)		breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(1)|prostate(1)	13						AGATTACAAAGACATAGAACA	0.343000													5	16					2.0095e-06	2.48886e-06	0.248553	1	0
REG3G	130120	broad.mit.edu	37	2	79253232	79253232	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:79253232A>G	ENST00000272324.5	+	2	197	c.13A>G	c.(13-15)Atg>Gtg	p.M5V	REG3G_ENST00000393897.2_Missense_Mutation_p.M5V|REG3G_ENST00000409471.1_Missense_Mutation_p.M5V	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	5					acute-phase response	extracellular region	sugar binding	p.M5V(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GCTGCCTCCCATGGCCCTGCC	0.542000													10	22					0	0	0.387290	0	0
SCLT1	132320	broad.mit.edu	37	4	129880846	129880846	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:129880846C>A	ENST00000281142.5	-	12	1459	c.956G>T	c.(955-957)tGc>tTc	p.C319F	SCLT1_ENST00000439369.2_Intron|SCLT1_ENST00000503215.1_Intron|SCLT1_ENST00000434680.1_Intron|SCLT1_ENST00000502495.1_5'UTR	NM_144643.2	NP_653244.2	Q96NL6	SCLT1_HUMAN	sodium channel and clathrin linker 1	319						centrosome		p.C319F(2)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	29						TAATTCATTGCACTTTGCTTG	0.358000													44	46					9.84934e-19	1.73702e-18	0.853193	1	0
SLCO1C1	53919	broad.mit.edu	37	12	20870080	20870080	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:20870080G>T	ENST00000381552.1	+	7	1059	c.691G>T	c.(691-693)Gtt>Ttt	p.V231F	SLCO1C1_ENST00000540354.1_Missense_Mutation_p.V182F|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.V113F|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.V231F|SLCO1C1_ENST00000266509.2_Missense_Mutation_p.V231F			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	231					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity	p.V231F(2)		NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					TGTGCAGACGGTTGCAATTAT	0.333000													13	26					0.000308642	0.000348363	0.479597	1	0
PIP4K2A	5305	broad.mit.edu	37	10	22880696	22880696	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:22880696C>T	ENST00000376573.4	-	4	582	c.354G>A	c.(352-354)agG>agA	p.R118R	PIP4K2A_ENST00000422321.1_5'UTR|PIP4K2A_ENST00000545335.1_Silent_p.R59R	NM_005028.4	NP_005019.2	P48426	PI42A_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	118	PIPK.						1-phosphatidylinositol-4-phosphate 5-kinase activity|1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding	p.R118R(1)		endometrium(4)|kidney(13)|large_intestine(4)|lung(6)|ovary(1)|skin(1)	29						GGGGTGCGCTCCTGGTCAGGG	0.522000													18	26					0	0	0.592651	0	0
NBPF10	100132406	broad.mit.edu	37	1	145303954	145303954	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:145303954G>A	ENST00000342960.5	+	9	1386	c.1351G>A	c.(1351-1353)Gag>Aag	p.E451K	NBPF10_ENST00000369338.1_Missense_Mutation_p.E180K|NBPF10_ENST00000369339.2_Missense_Mutation_p.E180K|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	451								p.E180K(1)|p.E451K(1)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		TGAGGTGGCTGAGAAAGTGCA	0.433000													7	300					0	0	0.278610	0	0
LOC100130331	100130331	broad.mit.edu	37	1	238090572	238090572	+	RNA	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:238090572C>A	ENST00000450451.1	+	0	2078					NR_027247.2																						TCTGGGCGCACCAGTGGCATT	0.582000													3	20					0.115264	0.117991	0.115264	1	0
TBX20	57057	broad.mit.edu	37	7	35242325	35242325	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:35242325G>T	ENST00000408931.3	-	8	1587	c.1061C>A	c.(1060-1062)tCc>tAc	p.S354Y		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	354						nucleus	DNA binding	p.S354Y(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						AGGAAAACTGGAAGAAGATGA	0.483000													3	4					0.115264	0.117991	0.115264	1	0
DCN	1634	broad.mit.edu	37	12	91539908	91539908	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:91539908T>A	ENST00000052754.5	-	8	1508	c.1007A>T	c.(1006-1008)tAc>tTc	p.Y336F	DCN_ENST00000441303.2_Missense_Mutation_p.Y149F|DCN_ENST00000425043.1_Missense_Mutation_p.Y189F|DCN_ENST00000228329.5_Missense_Mutation_p.Y227F|DCN_ENST00000393155.1_Missense_Mutation_p.Y336F|DCN_ENST00000420120.2_Missense_Mutation_p.Y227F|DCN_ENST00000547568.2_Missense_Mutation_p.Y189F|DCN_ENST00000552962.1_Missense_Mutation_p.Y336F|DCN_ENST00000303320.3_Missense_Mutation_p.Y149F	NM_001920.3	NP_001911.1	P07585	PGS2_HUMAN	decorin	336					organ morphogenesis	extracellular space		p.Y336F(1)		central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						TATCTCCCAGTACTGGACCGG	0.448000													5	45					0	0	0.184627	0	0
IGHV3-74	28408	broad.mit.edu	37	14	107218737	107218737	+	RNA	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:107218737G>T	ENST00000424969.2	-	0	525																											CAGATACAGCGTGTTCTTGGC	0.517000													65	95					6.52717e-41	1.27211e-40	0.870114	1	0
KLHL9	55958	broad.mit.edu	37	9	21334168	21334168	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:21334168C>A	ENST00000359039.4	-	1	1211	c.691G>T	c.(691-693)Gat>Tat	p.D231Y	KLHL9_ENST00000537938.1_Missense_Mutation_p.D163Y			Q9P2J3	KLHL9_HUMAN	kelch-like family member 9	231	BACK.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody		p.D231Y(1)		endometrium(9)|large_intestine(7)|lung(10)|ovary(4)|skin(2)	32				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		GCAGCATAATCCATCCGAGGG	0.423000													22	43					3.8784e-16	6.57202e-16	0.608945	1	0
MAP2	4133	broad.mit.edu	37	2	210561338	210561338	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:210561338G>T	ENST00000360351.4	+	8	4759	c.4253G>T	c.(4252-4254)cGg>cTg	p.R1418L	MAP2_ENST00000475600.1_3'UTR|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000199940.6_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000447185.1_Missense_Mutation_p.R1414L	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	1418					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity	p.R1418L(1)		breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AAGGAAGCTCGGAGATCATCT	0.393000													15	49					1.05317e-09	1.50221e-09	0.457914	1	0
OR8H2	390151	broad.mit.edu	37	11	55873241	55873241	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:55873241C>A	ENST00000313503.1	+	1	723	c.723C>A	c.(721-723)tgC>tgA	p.C241*		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C241*(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					TCTCTACTTGCGTCTCTCATC	0.378000										HNSCC(53;0.14)			20	41					1.90627e-21	3.51468e-21	0.608945	1	0
LTF	4057	broad.mit.edu	37	3	46492017	46492017	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:46492017C>G	ENST00000231751.4	-	7	1145	c.850G>C	c.(850-852)Gat>Cat	p.D284H	LTF_ENST00000426532.2_Missense_Mutation_p.D240H|LTF_ENST00000417439.1_Missense_Mutation_p.D284H	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	284	Transferrin-like 1.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity	p.D284H(1)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	CAGATGGCATCCTCCTTGCCA	0.567000													10	14					0	0	0.335167	0	0
PTPRN	5798	broad.mit.edu	37	2	220162048	220162048	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:220162048G>T	ENST00000295718.2	-	14	2235	c.1995C>A	c.(1993-1995)gcC>gcA	p.A665A	PTPRN_ENST00000409251.3_Silent_p.A636A|PTPRN_ENST00000423636.2_Silent_p.A575A	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	665					response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity	p.A665A(1)		breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		GGCTGGCCTGGGCTGCGTCGC	0.652000													23	50					9.57634e-11	1.41573e-10	0.654019	1	0
TLR3	7098	broad.mit.edu	37	4	187004712	187004712	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:187004712C>T	ENST00000296795.2	+	4	1976	c.1872C>T	c.(1870-1872)tcC>tcT	p.S624S	TLR3_ENST00000504367.1_Silent_p.S347S	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	624					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity	p.S624S(1)		breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		TCATAACATCCGTTGAGAAGA	0.393000													5	56					0	0	0.184627	0	0
KRT39	390792	broad.mit.edu	37	17	39119941	39119941	+	Missense_Mutation	SNP	G	G	T	rs145339869	byFrequency	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:39119941G>T	ENST00000355612.2	-	3	681	c.646C>A	c.(646-648)Cta>Ata	p.L216I	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	216	Coil 1B.|Rod.					intermediate filament	structural molecule activity	p.L216I(1)		NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				TGTGCCTCTAGGTCGGCCTTG	0.498000													20	65					1.55795e-14	2.54687e-14	0.608945	1	0
KIAA2026	158358	broad.mit.edu	37	9	5921606	5921606	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:5921606C>A	ENST00000399933.3	-	8	4389	c.4390G>T	c.(4390-4392)Gta>Tta	p.V1464L	KIAA2026_ENST00000381461.2_Missense_Mutation_p.V1434L	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	1464								p.V639L(1)|p.V1464L(1)		breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		CCACTGATTACATCTCCATTT	0.388000													18	48					0.00395357	0.00426933	0.667858	1	0
GUCA1C	9626	broad.mit.edu	37	3	108626994	108626994	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:108626994C>A	ENST00000261047.3	-	4	637	c.505G>T	c.(505-507)Gtt>Ttt	p.V169F	GUCA1C_ENST00000393963.3_Missense_Mutation_p.C182F	NM_005459.3	NP_005450.3	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	169					signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity	p.V169F(1)		endometrium(2)|large_intestine(1)|liver(1)|lung(8)|pancreas(1)|skin(1)	14						CTCTTGTAAACAATCTCCAGG	0.418000													11	37					1.36491e-13	2.17648e-13	0.435327	1	0
ZNF432	9668	broad.mit.edu	37	19	52538395	52538395	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:52538395G>A	ENST00000594154.1	-	5	749	c.537C>T	c.(535-537)ttC>ttT	p.F179F	ZNF432_ENST00000221315.5_Silent_p.F179F			O94892	ZN432_HUMAN	zinc finger protein 432	179					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F179F(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TACTTACAGAGAATTTAGCTG	0.348000													3	85					0	0	0.115264	0	0
ZNF836	162962	broad.mit.edu	37	19	52659499	52659499	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:52659499G>A	ENST00000322146.8	-	5	1958	c.1437C>T	c.(1435-1437)ttC>ttT	p.F479F	CTC-471J1.8_ENST00000594362.1_RNA|ZNF836_ENST00000597252.1_Silent_p.F479F	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	479					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F479F(2)		endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						AAGTCTGACTGAAGACCTTGC	0.428000													54	54					0	0	0.870114	0	0
LRRC7	57554	broad.mit.edu	37	1	70452024	70452024	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:70452024C>A	ENST00000310961.5	+	11	1205	c.787C>A	c.(787-789)Ctc>Atc	p.L263I	LRRC7_ENST00000415775.2_5'UTR|LRRC7_ENST00000035383.5_Missense_Mutation_p.L258I			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	258						centrosome|focal adhesion|nucleolus	protein binding	p.L258I(1)		breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CCTTGAGGACCTCTTATTGTC	0.328000													3	35					0.00909568	0.00961416	0.150653	1	0
GPR61	83873	broad.mit.edu	37	1	110086428	110086428	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:110086428C>G	ENST00000527748.1	+	2	1467	c.784C>G	c.(784-786)Cgc>Ggc	p.R262G	RP5-1160K1.8_ENST00000526411.1_RNA	NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	262						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R262G(1)		breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		TCTCAGCAGCCGCTCCACGAT	0.682000													21	76					0	0	0.608945	0	0
HEATR1	55127	broad.mit.edu	37	1	236727849	236727849	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:236727849C>T	ENST00000366582.3	-	32	4662	c.4548G>A	c.(4546-4548)ttG>ttA	p.L1516L	HEATR1_ENST00000366581.2_Silent_p.L1435L	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1516					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding	p.L1516L(1)		NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			AGGACACTGACAAAAATTTAA	0.348000													22	42					0	0	0.624587	0	0
C6orf118	168090	broad.mit.edu	37	6	165715241	165715241	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:165715241G>A	ENST00000543069.1	-	2	839	c.258C>T	c.(256-258)gcC>gcT	p.A86A	C6orf118_ENST00000230301.8_Silent_p.A190A			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	190								p.A190A(1)		breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CTCTGGACCCGGCCTCCTGGT	0.632000													10	45					0	0	0.361761	0	0
ZNF485	220992	broad.mit.edu	37	10	44112805	44112805	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:44112805G>T	ENST00000361807.3	+	5	1508	c.1314G>T	c.(1312-1314)atG>atT	p.M438I	ZNF485_ENST00000374437.2_Missense_Mutation_p.M347I|ZNF485_ENST00000374435.3_Missense_Mutation_p.M438I	NM_145312.3	NP_660355.2	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.M438I(1)|p.M399I(1)		breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16						AAAGAGCCATGAAATGTAGTT	0.343000													13	15					3.27435e-08	4.34572e-08	0.457914	1	0
BCLAF1	9774	broad.mit.edu	37	6	136596819	136596819	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:136596819T>C	ENST00000531224.1	-	6	1955	c.1703A>G	c.(1702-1704)gAc>gGc	p.D568G	BCLAF1_ENST00000527759.1_Missense_Mutation_p.D566G|BCLAF1_ENST00000530767.1_Missense_Mutation_p.D395G|BCLAF1_ENST00000392348.2_Missense_Mutation_p.D566G|BCLAF1_ENST00000527536.1_Missense_Mutation_p.D568G|BCLAF1_ENST00000353331.4_Missense_Mutation_p.D566G	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	568					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding	p.D568G(1)		haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		AAGCAGCCTGTCTTTAGTCAA	0.388000													4	112					0	0	0.248553	0	0
NIFK	84365	broad.mit.edu	37	2	122486106	122486106	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:122486106G>A	ENST00000285814.4	-	5	643	c.571C>T	c.(571-573)Cag>Tag	p.Q191*		NM_032390.4	NP_115766.3	Q9BYG3	MK67I_HUMAN		191					protein complex assembly|rRNA metabolic process|rRNA transcription	condensed nuclear chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|protein binding|RNA binding	p.Q191*(1)		endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|pancreas(1)|urinary_tract(1)	12						TCCGTTTTCTGTAAAATCTTT	0.279000													12	28					0	0	0.435327	0	0
LEFTY2	7044	broad.mit.edu	37	1	226128808	226128808	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:226128808C>A	ENST00000366820.5	-	1	381	c.33G>T	c.(31-33)tgG>tgT	p.W11C	LEFTY2_ENST00000420304.2_Missense_Mutation_p.W11C	NM_003240.3	NP_003231.2	O00292	LFTY2_HUMAN	left-right determination factor 2	11					cell growth|multicellular organismal development|platelet activation|platelet degranulation|transforming growth factor beta receptor signaling pathway	extracellular space|platelet alpha granule lumen	cytokine activity|growth factor activity|transforming growth factor beta receptor binding	p.W11C(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16	Breast(184;0.197)					GGGGCAGCACCCAGAGTGCCC	0.701000													4	13					0.184627	0.186932	0.184627	1	0
ABCB5	340273	broad.mit.edu	37	7	20793041	20793041	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:20793041G>T	ENST00000404938.2	+	27	4140	c.3488G>T	c.(3487-3489)aGa>aTa	p.R1163I	ABCB5_ENST00000258738.6_Missense_Mutation_p.R718I	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	718					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity	p.R1163I(1)|p.R718I(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						CAGAAACAAAGACTAGCTATT	0.418000													26	44					2.44723e-14	3.98058e-14	0.681144	1	0
RAI1	10743	broad.mit.edu	37	17	17701461	17701461	+	Silent	SNP	G	G	T	rs146112263	byFrequency	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:17701461G>T	ENST00000353383.1	+	3	5668	c.5199G>T	c.(5197-5199)tcG>tcT	p.S1733S	RAI1_ENST00000261641.6_Intron	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1733						cytoplasm|nucleus	zinc ion binding	p.S1733S(1)		breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		AGGAGGCCTCGCTGCCGCTTG	0.642000													13	29					7.03913e-09	9.69935e-09	0.411799	1	0
DZIP3	9666	broad.mit.edu	37	3	108363427	108363427	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:108363427G>T	ENST00000361582.3	+	14	1788	c.1558G>T	c.(1558-1560)Ggt>Tgt	p.G520C	DZIP3_ENST00000463306.1_Missense_Mutation_p.G520C	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	520					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding	p.G520C(1)		breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						TTTGATGAATGGTCTCACTGA	0.403000													32	83					4.02929e-09	5.64796e-09	0.750413	1	0
KDR	3791	broad.mit.edu	37	4	55946163	55946163	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:55946163G>T	ENST00000263923.4	-	30	4311	c.4016C>A	c.(4015-4017)aCa>aAa	p.T1339K	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1339					angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.T1339K(1)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	AATCTGGGCTGTGCTACCGGT	0.522000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			34	100					6.84511e-11	1.01659e-10	0.779181	1	0
RPL10L	140801	broad.mit.edu	37	14	47120456	47120456	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:47120456G>T	ENST00000298283.3	-	1	572	c.484C>A	c.(484-486)Cgc>Agc	p.R162S		NM_080746.2	NP_542784.1	Q96L21	RL10L_HUMAN	ribosomal protein L10-like	162					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome	p.R162S(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(20)|ovary(1)	27						ATCTTCTGGCGTCCAGGGAAC	0.502000													23	34					4.26978e-12	6.55103e-12	0.654019	1	0
KRTAP4-8	728224	broad.mit.edu	37	17	39254054	39254054	+	Missense_Mutation	SNP	A	A	T	rs76270529	by1000genomes	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:39254054A>T	ENST00000333822.4	-	1	339	c.283T>A	c.(283-285)Tgc>Agc	p.C95S		NM_031960.2	NP_114166.1	Q9BYQ9	KRA48_HUMAN	keratin associated protein 4-8	95	25 X 5 AA repeats of C-C-[IKRQVHEC]- [SPRT]-[STCVQPR].					keratin filament		p.C95S(4)		endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|prostate(1)	11						ctggagatgcagcagcTAGGG	0.677000													5	28					0	0	0.184627	0	0
UXS1	80146	broad.mit.edu	37	2	106761802	106761802	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:106761802C>A	ENST00000283148.7	-	6	413	c.316G>T	c.(316-318)Ggc>Tgc	p.G106C	UXS1_ENST00000540130.1_Missense_Mutation_p.G44C|UXS1_ENST00000479621.1_5'UTR|UXS1_ENST00000428048.2_Intron|UXS1_ENST00000409501.3_Missense_Mutation_p.G101C	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	101					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity	p.G101C(1)|p.G106C(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						AGATGGGAGCCCACGAACCCT	0.557000													10	20					0.00621372	0.00662184	0.335167	1	0
RNF5	6048	broad.mit.edu	37	6	32146358	32146358	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:32146358A>G	ENST00000427134.2	+	1	85	c.70A>G	c.(70-72)Acc>Gcc	p.T24A	RNF5_ENST00000487940.1_3'UTR|RNF5_ENST00000375094.3_Missense_Mutation_p.T24A			Q99942	RNF5_HUMAN	ring finger protein 5, E3 ubiquitin protein ligase	24					ER-associated misfolded protein catabolic process|protein K48-linked ubiquitination|protein K63-linked ubiquitination	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.T24A(1)		endometrium(1)|lung(7)|urinary_tract(2)	10						GGCGGGCGCGACCTTCGAATG	0.642000													14	37					0	0	0.539581	0	0
RTN4	57142	broad.mit.edu	37	2	55252705	55252705	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:55252705C>A	ENST00000337526.6	-	3	2773	c.2530G>T	c.(2530-2532)Gac>Tac	p.D844Y	RTN4_ENST00000357732.4_Intron|RTN4_ENST00000404909.1_Missense_Mutation_p.D638Y|RTN4_ENST00000317610.7_Intron|RTN4_ENST00000354474.6_Missense_Mutation_p.D612Y|RTN4_ENST00000405240.1_Missense_Mutation_p.D638Y|RTN4_ENST00000394611.2_Missense_Mutation_p.D638Y|RTN4_ENST00000357376.3_Missense_Mutation_p.D638Y|RTN4_ENST00000402434.2_Intron	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	844					apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding	p.D844Y(1)|p.D638Y(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						ATAAATAAGTCATCATTTGAA	0.348000													9	64					1.12685e-05	1.35682e-05	0.307466	1	0
OR8J3	81168	broad.mit.edu	37	11	55904269	55904269	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:55904269C>A	ENST00000301529.1	-	1	925	c.926G>T	c.(925-927)tGt>tTt	p.C309F		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C309F(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					AAAGGAGTAACATGGATTTTC	0.313000													17	37					8.10497e-08	1.05838e-07	0.592651	1	0
ABCB4	5244	broad.mit.edu	37	7	87041230	87041230	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:87041230A>G	ENST00000265723.4	-	23	3014	c.2903T>C	c.(2902-2904)aTg>aCg	p.M968T	ABCB4_ENST00000359206.3_Missense_Mutation_p.M968T|ABCB4_ENST00000358400.3_Intron|ABCB4_ENST00000545634.1_Missense_Mutation_p.M968T|ABCB4_ENST00000453593.1_Intron	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	968	ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity	p.M968T(1)		breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TCTGAAGCGCATATGTCCATT	0.308000													10	35					0	0	0.335167	0	0
PCLO	27445	broad.mit.edu	37	7	82579217	82579217	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:82579217C>T	ENST00000423517.2	-	6	11024	c.10687G>A	c.(10687-10689)Ggc>Agc	p.G3563S	PCLO_ENST00000333891.8_Missense_Mutation_p.G3563S|PCLO_ENST00000437081.1_Missense_Mutation_p.G283S	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3494					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity	p.G3563S(2)|p.G3494S(1)		breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CCTAAACTGCCCCCTTTGTAA	0.448000													14	47					0	0	0.520397	0	0
COL19A1	1310	broad.mit.edu	37	6	70878091	70878091	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:70878091G>T	ENST00000322773.4	+	39	2627	c.2525G>T	c.(2524-2526)gGg>gTg	p.G842V	COL19A1_ENST00000393344.1_Missense_Mutation_p.G464V	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	842	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging	p.G842L(1)		breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						AGTTACCCAGGGCCACCCGGT	0.373000													8	22					1.12685e-05	1.35682e-05	0.307466	1	0
KCNJ12	3768	broad.mit.edu	37	17	21319719	21319719	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:21319719C>A	ENST00000583088.1	+	3	1960	c.1065C>A	c.(1063-1065)ccC>ccA	p.P355P	KCNJ12_ENST00000331718.5_Silent_p.P355P	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12									p.P355P(1)		NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		CCTCTACGCCCCGCTGCAGTG	0.577000										Prostate(3;0.18)			15	68					2.32078e-09	3.28146e-09	0.479597	1	0
CFH	3075	broad.mit.edu	37	1	196642292	196642292	+	Splice_Site	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:196642292G>T	ENST00000367429.4	+	2	483	c.244_splice	c.e2+1	p.Q81_splice	CFH_ENST00000496761.1_3'UTR|CFH_ENST00000439155.2_Splice_Site_p.Q81_splice|CFH_ENST00000359637.2_Splice_Site_p.Q81_splice	NM_000186.3	NP_000177.2	P08603	CFAH_HUMAN	complement factor H	81	Sushi 1.				complement activation, alternative pathway	extracellular space		p.Q81H(1)|p.Q81Q(1)		NS(3)|breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(24)|lung(33)|ovary(1)|prostate(5)|skin(9)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	101						GGAAATGTCAGAGTAAGTACT	0.318000													17	62					7.81268e-19	1.38536e-18	0.520397	1	0
LAMA4	3910	broad.mit.edu	37	6	112537579	112537579	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:112537579C>G	ENST00000230538.7	-	3	684	c.287G>C	c.(286-288)gGa>gCa	p.G96A	LAMA4_ENST00000424408.2_Missense_Mutation_p.G96A|LAMA4_ENST00000522006.1_Missense_Mutation_p.G96A|LAMA4_ENST00000431543.2_Missense_Mutation_p.G96A|LAMA4_ENST00000389463.4_Missense_Mutation_p.G96A|LAMA4_ENST00000524032.1_5'UTR	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	96	Laminin EGF-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding	p.G96A(1)		NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		CACACAGTATCCTGAGCCGTC	0.468000													15	32					0	0	0.520397	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153283102	153283102	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:153283102C>A	ENST00000290722.1	-	1	92	c.40G>T	c.(40-42)Ggt>Tgt	p.G14C		NM_052891.1	NP_443123.1	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3	14					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding	p.G14C(1)		breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(1)|liver(1)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	28	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCTGGAGACCCAGAATGAAG	0.502000													44	101					1.86633e-21	3.45086e-21	0.870114	1	0
CC2D1B	200014	broad.mit.edu	37	1	52819274	52819274	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:52819274C>A	ENST00000371586.2	-	24	2632	c.2494G>T	c.(2494-2496)Gtg>Ttg	p.V832L	RP11-155O18.6_ENST00000606527.1_RNA|CC2D1B_ENST00000460261.1_5'UTR|CC2D1B_ENST00000284376.3_Missense_Mutation_p.V826L	NM_032449.2	NP_115825.1	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	832								p.V832L(1)		breast(1)|large_intestine(6)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	27						CGCAGCCTCACCTTCACCTCC	0.612000													7	10					0.000274275	0.000311742	0.307466	1	0
EPHX4	253152	broad.mit.edu	37	1	92511171	92511171	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:92511171G>T	ENST00000370383.4	+	4	656	c.558G>T	c.(556-558)gtG>gtT	p.V186V		NM_173567.4	NP_775838.3	Q8IUS5	EPHX4_HUMAN	epoxide hydrolase 4	186						integral to membrane	hydrolase activity	p.V186V(1)		central_nervous_system(1)|large_intestine(3)|lung(8)	12						CTGAAATGGTGATGAAGCTTA	0.373000													33	50					2.47316e-13	3.90579e-13	0.779181	1	0
ADAM15	8751	broad.mit.edu	37	1	155030752	155030752	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:155030752G>A	ENST00000356955.2	+	15	1853	c.1752G>A	c.(1750-1752)caG>caA	p.Q584Q	ADAM15_ENST00000368413.1_Silent_p.Q290Q|ADAM15_ENST00000368410.2_Silent_p.Q290Q|ADAM15_ENST00000368412.3_Silent_p.Q584Q|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000449910.2_Silent_p.Q584Q|ADAM15_ENST00000447332.3_Silent_p.Q568Q|ADAM15_ENST00000531455.1_Silent_p.Q594Q|ADAM15_ENST00000271836.6_Silent_p.Q584Q|ADAM15_ENST00000360674.4_Silent_p.Q584Q|ADAM15_ENST00000359280.4_Silent_p.Q584Q|ADAM15_ENST00000355956.2_Silent_p.Q584Q	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	584	Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding	p.Q584Q(1)		NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TCCAGTGCCAGACAGGTAGGA	0.587000													6	42					0	0	0.278610	0	0
GBA3	57733	broad.mit.edu	37	4	22820507	22820507	+	RNA	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:22820507C>A	ENST00000508264.1	+	0	329				GBA3_ENST00000511446.1_RNA|GBA3_ENST00000508166.1_RNA|GBA3_ENST00000503442.1_RNA			Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AGGAATAAGCCAAGATCATCC	0.498000													6	19					3.59834e-05	4.25377e-05	0.217242	1	0
OR2W3	343171	broad.mit.edu	37	1	248059478	248059478	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:248059478G>T	ENST00000537741.1	+	3	847	c.590G>T	c.(589-591)gGc>gTc	p.G197V	OR2W3_ENST00000360358.3_Missense_Mutation_p.G197V			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G197V(1)		breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCCATCGAAGGCACCGTCTTT	0.592000													16	66					3.80469e-20	6.85902e-20	0.740014	1	0
TAAR2	9287	broad.mit.edu	37	6	132938667	132938667	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:132938667C>T	ENST00000275191.2	-	1	650	c.543G>A	c.(541-543)gtG>gtA	p.V181V	TAAR2_ENST00000367931.1_Silent_p.V226V|TAAR2_ENST00000537809.1_Silent_p.V181V	NM_014626.3	NP_055441.2	Q9P1P5	TAAR2_HUMAN	trace amine associated receptor 2	226						plasma membrane	G-protein coupled receptor activity	p.G227W(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(1)	23	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00608)|GBM - Glioblastoma multiforme(226;0.0151)		CATAAATCCCCACCATCATAG	0.413000													13	43					0	0	0.479597	0	0
SSPO	23145	broad.mit.edu	37	7	149522153	149522153	+	RNA	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:149522153G>T	ENST00000378016.2	+	0	13940							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity	p.W32C(1)				Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCCTCTGTGGAGGAGGCTGC	0.662000													6	6					0.00116845	0.00129406	0.217242	1	0
OR4Q3	441669	broad.mit.edu	37	14	20215940	20215940	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:20215940C>A	ENST00000331723.1	+	1	354	c.354C>A	c.(352-354)gtC>gtA	p.V118V		NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V118V(1)		NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TGCTGACAGTCATGGCCTATG	0.498000													17	69					9.16793e-09	1.24477e-08	0.520397	1	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261693	39261693	+	Missense_Mutation	SNP	A	A	T	rs113059833	by1000genomes	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:39261693A>T	ENST00000391415.1	+	1	110	c.53A>T	c.(52-54)gAc>gTc	p.D18V		NM_001146041.1	NP_001139513.1	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	18						keratin filament		p.D18V(1)		central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(1)|urinary_tract(3)	14						TGCGGCCAAGACCTCTGTCAG	0.627000													4	28					0	0	0.217242	0	0
MYOM2	9172	broad.mit.edu	37	8	2027642	2027642	+	Splice_Site	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:2027642C>T	ENST00000262113.4	+	13	1605	c.1462_splice	c.e13-1	p.A488_splice	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	488					muscle contraction	myosin filament	structural constituent of muscle	p.A488A(1)		autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		TCTCCGCAGCCGTTCATTTGG	0.507000													24	145					0	0	0.717897	0	0
IMPG2	50939	broad.mit.edu	37	3	100962638	100962638	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:100962638C>A	ENST00000193391.7	-	13	2724	c.2537G>T	c.(2536-2538)gGc>gTc	p.G846V		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	846					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity	p.G846V(1)		NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						GTAATCTGTGCCTATCCGGTC	0.443000													37	75					4.07013e-28	7.81513e-28	0.840704	1	0
ADAMTS9	56999	broad.mit.edu	37	3	64527523	64527523	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:64527523C>A	ENST00000498707.1	-	33	5530	c.5188G>T	c.(5188-5190)Gtc>Ttc	p.V1730F	ADAMTS9_ENST00000295903.4_Missense_Mutation_p.V1702F	NM_182920.1	NP_891550.1	Q9P2N4	ATS9_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 9	1730	TSP type-1 15.				glycoprotein catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.V1730F(1)		breast(3)|central_nervous_system(4)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(17)|liver(4)|lung(43)|ovary(3)|prostate(3)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	100		Lung NSC(201;0.00682)		BRCA - Breast invasive adenocarcinoma(55;0.00142)|Kidney(15;0.00202)|KIRC - Kidney renal clear cell carcinoma(15;0.00221)		CAGTTATAGACATTACGGCAG	0.403000													26	73					8.16721e-17	1.40225e-16	0.750413	1	0
SAMD9L	219285	broad.mit.edu	37	7	92764413	92764413	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:92764413T>C	ENST00000318238.4	-	5	2088	c.872A>G	c.(871-873)gAa>gGa	p.E291G	SAMD9L_ENST00000411955.1_Missense_Mutation_p.E291G|SAMD9L_ENST00000437805.1_Missense_Mutation_p.E291G	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	291								p.E291G(1)		central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CAGAAGGACTTCCACAAACCT	0.363000													49	93					0	0	0.870114	0	0
CCDC178	374864	broad.mit.edu	37	18	30950088	30950088	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr18:30950088G>T	ENST00000383096.3	-	6	456	c.274C>A	c.(274-276)Cca>Aca	p.P92T	CCDC178_ENST00000300227.8_Missense_Mutation_p.P92T|CCDC178_ENST00000579916.1_Missense_Mutation_p.P92T|CCDC178_ENST00000579947.1_Missense_Mutation_p.P92T|CCDC178_ENST00000402325.1_Missense_Mutation_p.P92T|CCDC178_ENST00000403303.1_Missense_Mutation_p.P92T|CCDC178_ENST00000583930.1_Missense_Mutation_p.P92T|CCDC178_ENST00000406524.2_Missense_Mutation_p.P92T					coiled-coil domain containing 178									p.P92T(2)									CAAGGTGCTGGAATATTTACT	0.378000													19	19					2.37509e-13	3.76879e-13	0.592651	1	0
SNAPC3	6619	broad.mit.edu	37	9	15433602	15433602	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:15433602G>A	ENST00000380821.3	+	3	621	c.445G>A	c.(445-447)Gcc>Acc	p.A149T	SNAPC3_ENST00000461041.1_3'UTR	NM_001039697.1	NP_001034786.1	Q92966	SNPC3_HUMAN	small nuclear RNA activating complex, polypeptide 3, 50kDa	149					regulation of transcription, DNA-dependent|snRNA transcription|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding|protein binding	p.A149T(1)		breast(1)|endometrium(3)|large_intestine(6)|lung(2)	12				GBM - Glioblastoma multiforme(50;2.15e-06)		AATAGATCGAGCCTGCAGACA	0.348000													29	74					0	0	0.788014	0	0
DACH1	1602	broad.mit.edu	37	13	72049302	72049302	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:72049302C>A	ENST00000305425.4	-	10	2482	c.2060G>T	c.(2059-2061)gGc>gTc	p.G687V	DACH1_ENST00000313174.7_Missense_Mutation_p.G539V|DACH1_ENST00000354591.4_Missense_Mutation_p.G485V|DACH1_ENST00000359684.2_Missense_Mutation_p.G739V	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	737	DACHbox-C.|Interaction with SIN3A (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding	p.G687V(1)		NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		ATCTGTTCTGCCGCCACTGCG	0.408000													18	34					2.4624e-09	3.46658e-09	0.575678	1	0
ENTPD1	953	broad.mit.edu	37	10	97607405	97607405	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:97607405C>A	ENST00000371203.5	+	6	1189	c.602C>A	c.(601-603)cCt>cAt	p.P201H	ENTPD1_ENST00000453258.2_Missense_Mutation_p.P346H|ENTPD1_ENST00000543964.1_Missense_Mutation_p.P231H|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000539125.1_Missense_Mutation_p.P201H|RP11-429G19.3_ENST00000433113.1_RNA|ENTPD1_ENST00000371207.3_Missense_Mutation_p.P351H|ENTPD1_ENST00000371205.4_Missense_Mutation_p.P339H	NM_001164179.1|NM_001164182.1|NM_001776.5	NP_001157651.1|NP_001157654.1|NP_001767.3	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	339					cell adhesion	integral to plasma membrane	ATP binding	p.P339H(1)		cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		AGTTACTGCCCTTACTCCCAG	0.448000													28	55					6.38683e-12	9.75307e-12	0.729181	1	0
MYO1E	4643	broad.mit.edu	37	15	59553681	59553681	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:59553681C>A	ENST00000288235.4	-	3	574	c.175G>T	c.(175-177)Gtc>Ttc	p.V59F	MYO1E_ENST00000558814.1_Intron	NM_004998.3	NP_004989.2	Q12965	MYO1E_HUMAN	myosin IE	59	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity	p.V59F(1)		breast(1)|central_nervous_system(3)|endometrium(5)|kidney(4)|large_intestine(6)|lung(10)|pancreas(2)|prostate(1)|urinary_tract(1)	33				all cancers(107;0.207)		AAAGGGTTGACTGAGATTAAT	0.338000													24	54					3.6726e-16	6.23958e-16	0.667858	1	0
GRK5	2869	broad.mit.edu	37	10	121214575	121214575	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:121214575G>T	ENST00000392870.2	+	16	2098	c.1769G>T	c.(1768-1770)aGc>aTc	p.S590I	GRK5_ENST00000369108.3_Missense_Mutation_p.S485I	NM_005308.2	NP_005299.1	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	590					G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity	p.S590I(1)		endometrium(2)|large_intestine(5)|lung(15)|skin(3)|stomach(1)|urinary_tract(1)	27		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		ACCGGAAGCAGCTAGTTTCGG	0.552000													11	18					0.00136819	0.00150757	0.411799	1	0
GABRP	2568	broad.mit.edu	37	5	170224482	170224482	+	Silent	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:170224482T>A	ENST00000518525.1	+	7	935	c.471T>A	c.(469-471)acT>acA	p.T157T	GABRP_ENST00000265294.4_Silent_p.T157T|GABRP_ENST00000519598.1_Silent_p.T157T|GABRP_ENST00000519385.1_Silent_p.T157T			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	157						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.T157T(1)		NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCACGACAACTGTTGCATGTA	0.418000													15	45					0	0	0.520397	0	0
SLC5A2	6524	broad.mit.edu	37	16	31500068	31500068	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:31500068G>A	ENST00000330498.3	+	10	1274	c.1255G>A	c.(1255-1257)Gac>Aac	p.D419N		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	419					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity	p.D419N(1)		endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						ACGCGCCGGCGACCGCGAGCT	0.711000													10	14					0	0	0.361761	0	0
COL19A1	1310	broad.mit.edu	37	6	70878090	70878090	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:70878090G>T	ENST00000322773.4	+	39	2626	c.2524G>T	c.(2524-2526)Ggg>Tgg	p.G842W	COL19A1_ENST00000393344.1_Missense_Mutation_p.G464W	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	842	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging	p.G842L(1)		breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CAGTTACCCAGGGCCACCCGG	0.373000													8	22					1.12685e-05	1.35682e-05	0.307466	1	0
OR2AK2	391191	broad.mit.edu	37	1	248129425	248129425	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:248129425C>A	ENST00000366480.3	+	1	891	c.792C>A	c.(790-792)agC>agA	p.S264R	OR2L13_ENST00000366478.2_Intron	NM_001004491.1	NP_001004491.1	Q8NG84	O2AK2_HUMAN	olfactory receptor, family 2, subfamily AK, member 2	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S264R(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TTGTGGCAAGCCTGTTCTATG	0.493000													11	33					3.86212e-05	4.5573e-05	0.361761	1	0
LOC494141	494141	broad.mit.edu	37	11	18231471	18231471	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:18231471G>A	ENST00000527059.1	+	1	717	c.257G>A	c.(256-258)cGa>cAa	p.R86Q	RP11-113D6.10_ENST00000340135.3_Missense_Mutation_p.R86Q|RP11-113D6.10_ENST00000534640.1_Missense_Mutation_p.R86Q														p.R86Q(1)									GATGGATTTCGAAACTTGTAT	0.448000													13	38					0	0	0.411799	0	0
GRB2	2885	broad.mit.edu	37	17	73316501	73316501	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:73316501T>A	ENST00000578961.1	-	4	607	c.433A>T	c.(433-435)Aga>Tga	p.R145*	GRB2_ENST00000316804.5_Missense_Mutation_p.Q201L|GRB2_ENST00000462266.1_5'UTR|GRB2_ENST00000392564.1_Missense_Mutation_p.Q201L|GRB2_ENST00000392563.1_Missense_Mutation_p.Q160L|GRB2_ENST00000316615.5_Missense_Mutation_p.Q160L|GRB2_ENST00000392562.1_Missense_Mutation_p.Q201L			P62993	GRB2_HUMAN	growth factor receptor-bound protein 2	0	SH2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity	p.Q201L(1)		breast(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	17	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	CATGCCGGTCTGCCCGTGGCA	0.493000													41	131					0	0	0.859065	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590432	140590432	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:140590432G>T	ENST00000239450.2	+	1	2142	c.1953G>T	c.(1951-1953)ccG>ccT	p.P651P	PCDHB12_ENST00000541609.1_Silent_p.P314P	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		651	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.P651P(1)		NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGAGCCTCCGCGCTCGGCCA	0.731000													5	73					0.00307968	0.00333119	0.278610	1	0
RHAG	6005	broad.mit.edu	37	6	49578778	49578778	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:49578778G>T	ENST00000371175.4	-	7	1052	c.1026C>A	c.(1024-1026)ggC>ggA	p.G342G	RHAG_ENST00000229810.7_Intron	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	342					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding	p.G342G(1)		NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					TGCCTGCAAGGCCTCCCACTA	0.473000													14	52					1.3612e-06	1.70216e-06	0.479597	1	0
ZNF74	7625	broad.mit.edu	37	22	20761064	20761064	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr22:20761064G>T	ENST00000400451.2	+	5	2255	c.1741G>T	c.(1741-1743)Ggg>Tgg	p.G581W	ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000356671.5_Missense_Mutation_p.G581W|ZNF74_ENST00000405993.1_Missense_Mutation_p.G549W	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	581					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding	p.G581W(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCACAGCGAGGGGAAGCCCTT	0.572000													16	18					3.32936e-07	4.25345e-07	0.539581	1	0
PPARG	5468	broad.mit.edu	37	3	12475578	12475578	+	Silent	SNP	C	C	A	rs149367249	byFrequency	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:12475578C>A	ENST00000397026.2	+	9	1769	c.1386C>A	c.(1384-1386)atC>atA	p.I462I	PPARG_ENST00000397015.2_Silent_p.I456I|PPARG_ENST00000397000.1_3'UTR|PPARG_ENST00000397010.2_Silent_p.I456I|PPARG_ENST00000397012.2_Silent_p.I456I|PPARG_ENST00000309576.6_Silent_p.I456I|PPARG_ENST00000539812.1_3'UTR|PPARG_ENST00000287820.6_Silent_p.I484I			P37231	PPARG_HUMAN	peroxisome proliferator-activated receptor gamma	484	Ligand-binding.				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding	p.I484I(1)	PAX8/PPARG(117)	breast(2)|endometrium(4)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)	20					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	TGCAGGTGATCAAGAAGACGG	0.517000			T	PAX8	follicular thyroid		"""Insulin resistance ; lipodystrophy, familial partial L;diabetes mellitus, insulin-resistantI, with acanthosis nigricans and hypertension"""						10	32					0.00621372	0.00662184	0.335167	1	0
DOPEY2	9980	broad.mit.edu	37	21	37665644	37665644	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:37665644C>T	ENST00000399151.3	+	37	6757	c.6672C>T	c.(6670-6672)acC>acT	p.T2224T		NM_005128.2	NP_005119.2	Q9Y3R5	DOP2_HUMAN	dopey family member 2	2224					endoplasmic reticulum organization|Golgi to endosome transport|multicellular organismal development|protein transport	Golgi membrane		p.T2224T(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(6)|lung(25)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						ATGAGATCACCATGAAGAGTG	0.448000													3	63					0	0	0.115264	0	0
MUSK	4593	broad.mit.edu	37	9	113563055	113563055	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:113563055C>A	ENST00000416899.2	+	13	2499	c.2373C>A	c.(2371-2373)ggC>ggA	p.G791G	MUSK_ENST00000189978.5_Silent_p.G799G|MUSK_ENST00000374448.4_Silent_p.G799G			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	799	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.G799G(1)		breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						TCTCCTATGGCCTGCAGCCCT	0.542000													9	29					0.00621372	0.00662184	0.335167	1	0
H2AFY2	55506	broad.mit.edu	37	10	71851628	71851628	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:71851628C>A	ENST00000373255.4	+	4	659	c.395C>A	c.(394-396)cCa>cAa	p.P132Q		NM_018649.2	NP_061119.1	Q9P0M6	H2AW_HUMAN	H2A histone family, member Y2	132	Lys-rich.				chromatin modification|dosage compensation|nucleosome assembly	Barr body|nucleosome	DNA binding	p.P132Q(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(4)|skin(1)	15						TCCCCACCCCCAGAGAAAAGA	0.597000													19	17					8.10497e-08	1.05838e-07	0.592651	1	0
CACNA1F	778	broad.mit.edu	37	X	49065117	49065117	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:49065117G>T	ENST00000376265.2	-	43	5075	c.5014C>A	c.(5014-5016)Cgc>Agc	p.R1672S	CACNA1F_ENST00000323022.5_Missense_Mutation_p.R1661S|CACNA1F_ENST00000376251.1_Missense_Mutation_p.R1607S	NM_005183.2	NP_005174.2	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type, alpha 1F subunit	1672					axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity	p.R1672S(1)		autonomic_ganglia(1)|breast(8)|central_nervous_system(3)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(4)|urinary_tract(1)	85					Verapamil(DB00661)	GAGCCCCGGCGAGCTGAGGGC	0.567000													12	9					4.36969e-10	6.28809e-10	0.435327	1	0
SEZ6L2	26470	broad.mit.edu	37	16	29889672	29889672	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:29889672C>A	ENST00000308713.5	-	10	2175	c.1648G>T	c.(1648-1650)Ggc>Tgc	p.G550C	SEZ6L2_ENST00000537485.1_Missense_Mutation_p.G506C|SEZ6L2_ENST00000350527.3_Missense_Mutation_p.G480C|SEZ6L2_ENST00000346932.5_Missense_Mutation_p.G436C	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	550	CUB 3.					endoplasmic reticulum membrane|integral to membrane|plasma membrane		p.G480C(1)|p.G550C(1)		breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CAGTCTTGGCCCGGGCTATAG	0.602000													9	32					7.03913e-09	9.69935e-09	0.411799	1	0
ZSCAN20	7579	broad.mit.edu	37	1	33945125	33945125	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:33945125G>T	ENST00000361328.3	+	2	389	c.236G>T	c.(235-237)tGg>tTg	p.W79L	ZSCAN20_ENST00000373413.2_Missense_Mutation_p.W79L|ZSCAN20_ENST00000480917.1_3'UTR	NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	79	SCAN box.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.W79F(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				TGCTGTCGTTGGCTGAGGCCG	0.622000													6	29					2.0095e-06	2.48886e-06	0.248553	1	0
KIF4A	24137	broad.mit.edu	37	X	69622523	69622523	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:69622523C>A	ENST00000374403.3	+	23	2679	c.2597C>A	c.(2596-2598)gCc>gAc	p.A866D	KIF4A_ENST00000374388.3_Missense_Mutation_p.A866D	NM_012310.4	NP_036442.3	O95239	KIF4A_HUMAN	kinesin family member 4A	866	Interaction with PRC1.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding	p.A866D(1)		breast(6)|endometrium(9)|kidney(3)|large_intestine(8)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	51						GCCAAGTGTGCCCTGAAATAT	0.453000													10	4					2.17888e-05	2.60422e-05	0.335167	1	0
ZNF257	113835	broad.mit.edu	37	19	22270783	22270783	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:22270783G>T	ENST00000594947.1	+	4	375	c.231G>T	c.(229-231)atG>atT	p.M77I	ZNF257_ENST00000600162.1_3'UTR	NM_033468.2	NP_258429.2	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.M77I(1)		haematopoietic_and_lymphoid_tissue(2)|lung(4)	6		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTTTAGTTATGTGTTCTCATA	0.294000													9	24					5.68852e-11	8.46755e-11	0.307466	1	0
ZNF154	7710	broad.mit.edu	37	19	58213094	58213094	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:58213094G>T	ENST00000512439.2	-	3	1419	c.1223C>A	c.(1222-1224)aCt>aAt	p.T408N	ZNF154_ENST00000426889.1_Missense_Mutation_p.T408N|AC003006.7_ENST00000599221.1_Intron|AC003006.7_ENST00000596085.1_Intron			Q13106	ZN154_HUMAN	zinc finger protein 154	408						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.T408N(2)		endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTTCTCCCCAGTGTGAACCCT	0.443000													36	31					4.4194e-11	6.624e-11	0.769981	1	0
CACHD1	57685	broad.mit.edu	37	1	65098382	65098382	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:65098382G>C	ENST00000371073.2	+	6	745	c.745G>C	c.(745-747)Gac>Cac	p.D249H	CACHD1_ENST00000495994.1_Intron|CACHD1_ENST00000290039.5_Missense_Mutation_p.D198H			Q5VU97	CAHD1_HUMAN	cache domain containing 1	249	VWFA.				calcium ion transport	integral to membrane		p.D198H(1)		breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						GATTGCCAAGGACGCTGCTCA	0.522000													20	24					0	0	0.608945	0	0
MARS2	92935	broad.mit.edu	37	2	198571111	198571111	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:198571111G>T	ENST00000282276.6	+	1	1025	c.982G>T	c.(982-984)Ggc>Tgc	p.G328C	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	328					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity	p.G328C(1)		breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	GTTAGGGGCCGGCATGAGCCC	0.537000													47	124					1.61863e-15	2.73565e-15	0.870114	1	0
TTN	7273	broad.mit.edu	37	2	179449567	179449567	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:179449567C>T	ENST00000589042.1	-	310	65025	c.64801G>A	c.(64801-64803)Gat>Aat	p.D21601N	TTN_ENST00000460472.2_Missense_Mutation_p.D12536N|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D19033N|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D12728N|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D19960N|TTN-AS1_ENST00000592750.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D12661N|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19960	Fibronectin type-III 57.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.D19033N(1)|p.D12661N(1)|p.D19031N(1)|p.D12536N(1)|p.D12728N(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGGCTTACATCACACTTCTCC	0.507000													16	151					0	0	0.520397	0	0
F2	2147	broad.mit.edu	37	11	46744801	46744801	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:46744801C>A	ENST00000311907.5	+	5	444	c.388C>A	c.(388-390)Cag>Aag	p.Q130K	F2_ENST00000530231.1_Missense_Mutation_p.Q130K	NM_000506.3	NP_000497.1	P00734	THRB_HUMAN	coagulation factor II (thrombin)	130	Kringle 1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity	p.Q130K(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	27		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	CATTGAGTGCCAGCTATGGAG	0.607000													18	76					9.16793e-09	1.24477e-08	0.520397	1	0
EFS	10278	broad.mit.edu	37	14	23828659	23828659	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:23828659C>A	ENST00000216733.3	-	4	1635	c.1028G>T	c.(1027-1029)cGc>cTc	p.R343L	EFS_ENST00000429593.2_Missense_Mutation_p.R174L|EFS_ENST00000351354.3_Missense_Mutation_p.R250L	NM_005864.2	NP_005855.1	O43281	EFS_HUMAN	embryonal Fyn-associated substrate	343	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding	p.R343L(1)		endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)	16	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		ACCAGGCAGGCGGGGTGGGGG	0.692000													11	43					7.03913e-09	9.69935e-09	0.411799	1	0
HIST1H2AC	8334	broad.mit.edu	37	6	26124812	26124812	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:26124812C>G	ENST00000602637.1	+	1	382	c.352C>G	c.(352-354)Cct>Gct	p.P118A	HIST1H2AC_ENST00000377791.2_Missense_Mutation_p.P118A			Q93077	H2A1C_HUMAN	histone cluster 1, H2ac	118					nucleosome assembly	nucleosome|nucleus	DNA binding	p.P118A(1)|p.P118T(1)		NS(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|lung(5)	12						CGTGCTTCTGCCTAAGAAGAC	0.567000													25	51					0	0	0.706142	0	0
REG1P	5969	broad.mit.edu	37	2	79363206	79363206	+	RNA	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:79363206G>A	ENST00000444841.1	-	0	1132																											GGCAGTTCTAGATGGGGAAGG	0.507000													5	13					0	0	0.217242	0	0
OTUB2	78990	broad.mit.edu	37	14	94510400	94510400	+	Splice_Site	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:94510400C>T	ENST00000203664.5	+	4	511	c.303_splice	c.e4+1	p.A101_splice		NM_023112.3	NP_075601.1	Q96DC9	OTUB2_HUMAN	OTU domain, ubiquitin aldehyde binding 2	101	OTU.				cellular amino acid metabolic process|protein K48-linked deubiquitination|protein K63-linked deubiquitination		omega peptidase activity|protein binding|ubiquitin-specific protease activity	p.A101V(1)		kidney(1)|large_intestine(1)|lung(2)|ovary(1)	5		all_cancers(154;0.12)		Epithelial(152;0.124)|all cancers(159;0.21)|COAD - Colon adenocarcinoma(157;0.215)		TTCTTCAATGCTGTGAGTTCA	0.567000													39	54					0	0	0.819951	0	0
FAM47B	170062	broad.mit.edu	37	X	34962859	34962859	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:34962859C>A	ENST00000329357.5	+	1	1947	c.1911C>A	c.(1909-1911)gaC>gaA	p.D637E		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	637								p.D637E(1)		breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						ACAAAGAAGACGTCACAGATG	0.378000													38	19					1.07121e-22	2.01511e-22	0.827153	1	0
CADPS	8618	broad.mit.edu	37	3	62751616	62751616	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:62751616G>T	ENST00000383710.4	-	2	834	c.485C>A	c.(484-486)gCt>gAt	p.A162D	CADPS_ENST00000283269.9_Missense_Mutation_p.A162D|CADPS_ENST00000490353.2_Missense_Mutation_p.A162D|CADPS_ENST00000357948.3_Missense_Mutation_p.A162D	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	162					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding	p.A162D(2)		breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		ATTGAGGAAAGCCTGAAACCG	0.468000													25	71					5.61819e-17	9.67163e-17	0.693898	1	0
KIF1B	23095	broad.mit.edu	37	1	10363995	10363995	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:10363995C>A	ENST00000377093.4	+	21	2905	c.2752C>A	c.(2752-2754)Cgt>Agt	p.R918S	KIF1B_ENST00000377083.1_Missense_Mutation_p.R918S|KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377086.1_Intron	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding	p.R918S(1)		breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		TAGACGTGGACGTCTGCGCTG	0.453000													6	29					0.0215528	0.0223804	0.217242	1	0
ARMC8	25852	broad.mit.edu	37	3	137960639	137960639	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:137960639G>T	ENST00000469044.1	+	11	1123	c.852G>T	c.(850-852)ttG>ttT	p.L284F	ARMC8_ENST00000481646.1_Missense_Mutation_p.L270F|ARMC8_ENST00000393058.3_Missense_Mutation_p.L274F|ARMC8_ENST00000461822.1_Intron|ARMC8_ENST00000470821.1_Missense_Mutation_p.L284F|ARMC8_ENST00000471453.1_Missense_Mutation_p.L270F|ARMC8_ENST00000491704.1_Missense_Mutation_p.L242F|ARMC8_ENST00000485396.1_Missense_Mutation_p.L211F|ARMC8_ENST00000489213.1_Missense_Mutation_p.L242F|ARMC8_ENST00000538260.1_Missense_Mutation_p.L253F|ARMC8_ENST00000358441.2_Missense_Mutation_p.L270F	NM_001267041.1|NM_001267042.1	NP_001253970.1|NP_001253971.1	Q8IUR7	ARMC8_HUMAN	armadillo repeat containing 8	284							binding	p.L270F(2)		endometrium(2)|kidney(1)|large_intestine(7)|lung(5)|upper_aerodigestive_tract(1)	16						TACCTTGTTTGGTTCGAATGT	0.378000													21	37					8.10497e-08	1.05838e-07	0.592651	1	0
MUC1	4582	broad.mit.edu	37	1	155160273	155160273	+	Missense_Mutation	SNP	C	C	A	rs144273480		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:155160273C>A	ENST00000368395.1	-	5	1077	c.1006G>T	c.(1006-1008)Gac>Tac	p.D336Y	MUC1_ENST00000368398.3_Missense_Mutation_p.D91Y|MUC1_ENST00000368393.3_Missense_Mutation_p.D134Y|MUC1_ENST00000368392.3_Missense_Mutation_p.D125Y|MUC1_ENST00000368389.2_Intron|MUC1_ENST00000342482.4_Intron|MUC1_ENST00000343256.5_Intron|MUC1_ENST00000338684.5_Missense_Mutation_p.D85Y|MUC1_ENST00000438413.1_Missense_Mutation_p.D90Y|MUC1_ENST00000368390.3_Missense_Mutation_p.D116Y|MUC1_ENST00000462215.1_5'UTR|MUC1_ENST00000457295.2_Missense_Mutation_p.D125Y|MUC1_ENST00000337604.5_Missense_Mutation_p.D134Y|MUC1_ENST00000368396.4_Intron	NM_001204285.1|NM_001204286.1	NP_001191214.1|NP_001191215.1	P15941	MUC1_HUMAN	mucin 1, cell surface associated	1116	42 X 20 AA approximate tandem repeats of P-A-P-G-S-T-A-P-P-A-H-G-V-T-S-A-P-D-T-R.					apical plasma membrane|cell surface|cytoplasm|extracellular region|integral to plasma membrane|nucleus	protein binding	p.D134Y(1)|p.D125Y(1)|p.D336Y(1)		breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|skin(2)	10	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;5.31e-10)|all cancers(21;2.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GTCTCCACGTCGTGGACATTG	0.542000			T	IGH@	B-NHL								8	20					0.000157383	0.000181747	0.278610	1	0
MATK	4145	broad.mit.edu	37	19	3784122	3784122	+	Splice_Site	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:3784122G>A	ENST00000310132.6	-	5	760	c.362_splice	c.e5+1	p.P121_splice	MATK_ENST00000395040.2_Splice_Site_p.P80_splice|MATK_ENST00000395045.2_Splice_Site_p.P122_splice|MATK_ENST00000585778.1_Splice_Site_p.P121_splice	NM_139355.2	NP_647612.1	P42679	MATK_HUMAN	megakaryocyte-associated tyrosine kinase	121					cell proliferation|mesoderm development|positive regulation of cell proliferation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity	p.P122L(1)|p.P121L(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(2)|stomach(2)|urinary_tract(1)	26		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCACTCACGGCATGAGGCT	0.701000													8	12					0	0	0.361761	0	0
FOXG1	2290	broad.mit.edu	37	14	29237494	29237494	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:29237494C>A	ENST00000382535.3	+	2	1378	c.1009C>A	c.(1009-1011)Cac>Aac	p.H337N	FOXG1_ENST00000313071.4_Missense_Mutation_p.H337N			P55316	FOXG1_HUMAN	forkhead box G1	337					axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.H337N(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(2)	43			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		CTACCCCAGCCACCCCATGCC	0.652000													30	94					0.000279167	0.000316747	0.740014	1	0
UPF3B	65109	broad.mit.edu	37	X	118979178	118979178	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:118979178A>C	ENST00000276201.2	-	4	521	c.452T>G	c.(451-453)gTc>gGc	p.V151G	UPF3B_ENST00000345865.2_Missense_Mutation_p.V151G|UPF3B_ENST00000478840.1_5'UTR	NM_080632.2	NP_542199.1	Q9BZI7	REN3B_HUMAN	UPF3 regulator of nonsense transcripts homolog B (yeast)	151	Necessary for interaction with UPF2.|Sufficient for association with EJC core.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|termination of RNA polymerase II transcription	cytosol|exon-exon junction complex|nucleoplasm	mRNA binding|nucleocytoplasmic transporter activity|nucleotide binding|protein binding	p.V151G(1)		breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|prostate(1)	30						GATAGTCCCGACTTTGGTATC	0.338000													36	22					0	0	0.834066	0	0
SLC2A10	81031	broad.mit.edu	37	20	45358045	45358045	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:45358045G>T	ENST00000359271.2	+	4	1715	c.1465G>T	c.(1465-1467)Ggc>Tgc	p.G489C		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	489						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity	p.G489C(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				CGCTGTCCTCGGCCTGGGCTT	0.562000													16	32					1.3612e-06	1.70216e-06	0.479597	1	0
SPEG	10290	broad.mit.edu	37	2	220344800	220344800	+	Silent	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:220344800A>T	ENST00000312358.7	+	25	5412	c.5280A>T	c.(5278-5280)acA>acT	p.T1760T	SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	1760	Protein kinase 1.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity	p.T1760T(1)		breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AGTATGGCACACCTGAGTTTG	0.607000													15	45					0	0	0.479597	0	0
OCA2	4948	broad.mit.edu	37	15	28195702	28195702	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:28195702C>A	ENST00000382996.2	-	19	2069	c.1960G>T	c.(1960-1962)Ggc>Tgc	p.G654C	OCA2_ENST00000354638.3_Intron|OCA2_ENST00000353809.5_Intron			Q04671	P_HUMAN	oculocutaneous albinism II	654					eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|lung(48)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		TGAACCAAGCCCAGGCCACCT	0.448000									Oculocutaneous Albinism				3	7					0.004672	0.00501178	0.115264	1	0
HUWE1	10075	broad.mit.edu	37	X	53643940	53643940	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:53643940C>T	ENST00000342160.3	-	20	2405	c.1948G>A	c.(1948-1950)Gat>Aat	p.D650N	HUWE1_ENST00000262854.6_Missense_Mutation_p.D650N|HUWE1_ENST00000218328.8_Missense_Mutation_p.D650N			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	650					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity	p.D650N(2)		NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CCAAGGGGATCAGAACTTCTC	0.403000													8	7					0	0	0.307466	0	0
ADAM33	80332	broad.mit.edu	37	20	3655206	3655206	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:3655206C>A	ENST00000356518.2	-	6	786	c.545G>T	c.(544-546)aGg>aTg	p.R182M	ADAM33_ENST00000350009.2_Missense_Mutation_p.R182M|ADAM33_ENST00000379861.4_Missense_Mutation_p.R182M	NM_025220.2	NP_079496.1	Q9BZ11	ADA33_HUMAN	ADAM metallopeptidase domain 33	182					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding	p.R182M(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|skin(3)	29						CCCAGGATCCCTGTGGCCACA	0.597000													37	62					2.20474e-14	3.59516e-14	0.788014	1	0
ZNF770	54989	broad.mit.edu	37	15	35273923	35273923	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:35273923G>A	ENST00000356321.4	-	3	2057	c.1713C>T	c.(1711-1713)gtC>gtT	p.V571V		NM_014106.3	NP_054825.2	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.V571V(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)	29		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		CTGACTCTGAGACCTCGTATT	0.398000													23	122					0	0	0.639603	0	0
ACTR3B	57180	broad.mit.edu	37	7	152549293	152549293	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:152549293C>T	ENST00000256001.8	+	10	1168	c.1034C>T	c.(1033-1035)gCt>gTt	p.A345V	ACTR3B_ENST00000537264.1_Missense_Mutation_p.A257V|ACTR3B_ENST00000377776.3_Intron|ACTR3B_ENST00000397282.2_Missense_Mutation_p.A257V	NM_020445.5	NP_065178.1	Q9P1U1	ARP3B_HUMAN	ARP3 actin-related protein 3 homolog B (yeast)	345					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding	p.A345V(1)		breast(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	13		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		GTGGTGGATGCTAGGCTGAGG	0.602000													9	42					0	0	0.361761	0	0
TEX35	84066	broad.mit.edu	37	1	178489853	178489853	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:178489853G>T	ENST00000367641.3	+	7	446	c.387G>T	c.(385-387)atG>atT	p.M129I	TEX35_ENST00000367643.3_Missense_Mutation_p.M129I|TEX35_ENST00000319416.2_Missense_Mutation_p.M129I|TEX35_ENST00000258298.2_Missense_Mutation_p.M53I|TEX35_ENST00000367642.3_3'UTR|TEX35_ENST00000367639.1_Missense_Mutation_p.M137I					testis expressed 35									p.M129I(2)									TCAGGCTGATGGGAAAGACTC	0.562000													5	21					0.014758	0.0154483	0.184627	1	0
BMP7	655	broad.mit.edu	37	20	55803293	55803293	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:55803293G>A	ENST00000395863.3	-	2	1108	c.603C>T	c.(601-603)caC>caT	p.H201H	BMP7_ENST00000450594.2_Silent_p.H201H|BMP7_ENST00000395864.3_Silent_p.H201H	NM_001719.2	NP_001710.1	P18075	BMP7_HUMAN	bone morphogenetic protein 7	201					BMP signaling pathway|cartilage development|cellular response to hypoxia|epithelial to mesenchymal transition|growth|mesonephros development|negative regulation of glomerular mesangial cell proliferation|negative regulation of MAP kinase activity|negative regulation of mitosis|negative regulation of neuron differentiation|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|negative regulation of phosphorylation|negative regulation of striated muscle cell apoptosis|negative regulation of transcription, DNA-dependent|ossification|pathway-restricted SMAD protein phosphorylation|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|protein localization to nucleus|regulation of removal of superoxide radicals|SMAD protein signal transduction|steroid hormone mediated signaling pathway|ureteric bud development	extracellular space	cytokine activity|growth factor activity	p.H201H(1)		endometrium(4)|kidney(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20	all_lung(29;0.0133)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;2.49e-13)|Epithelial(14;1.74e-08)|all cancers(14;2.05e-07)			ACCTGCCCAAGTGCTCCTGGA	0.572000													35	83					0	0	0.788014	0	0
ZNF2	7549	broad.mit.edu	37	2	95847613	95847613	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:95847613G>T	ENST00000398107.2	+	4	1436	c.914G>T	c.(913-915)tGt>tTt	p.C305F	ZNF2_ENST00000425369.1_Missense_Mutation_p.C267F|ZNF2_ENST00000453539.2_Missense_Mutation_p.C360F|ZNF2_ENST00000340539.5_Missense_Mutation_p.C347F|ZNF2_ENST00000295210.6_Missense_Mutation_p.C309F	NM_001017396.1	NP_001017396.1	Q9BSG1	ZNF2_HUMAN	zinc finger protein 2	346					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.C347F(1)		endometrium(4)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	12		Ovarian(717;0.00768)		READ - Rectum adenocarcinoma(193;0.0222)		TGTAACGAGTGTGGCAAAGCT	0.488000													31	48					9.65021e-13	1.49832e-12	0.750413	1	0
IQCJ	654502	broad.mit.edu	37	3	158983125	158983125	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:158983125C>T	ENST00000482126.1	+	4	437	c.332C>T	c.(331-333)cCc>cTc	p.P111L	IQCJ_ENST00000451172.1_Missense_Mutation_p.P138L|IQCJ-SCHIP1_ENST00000476809.1_Intron|IQCJ-SCHIP1_ENST00000467442.1_Intron|IQCJ-SCHIP1_ENST00000485419.1_Intron	NM_001197100.1	NP_001184029.1			IQ motif containing J									p.P138L(1)		cervix(1)|endometrium(2)|large_intestine(2)|lung(10)	15			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			CTTGCCAGACCCACTGGGTTC	0.483000													18	58					0	0	0.520397	0	0
ASTL	431705	broad.mit.edu	37	2	96789930	96789930	+	Nonsense_Mutation	SNP	C	C	A	rs147267731	byFrequency	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:96789930C>A	ENST00000342380.2	-	9	954	c.955G>T	c.(955-957)Gaa>Taa	p.E319*		NM_001002036.3	NP_001002036.3	Q6HA08	ASTL_HUMAN	astacin-like metallo-endopeptidase (M12 family)	319					proteolysis		metalloendopeptidase activity|zinc ion binding	p.E319*(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(2)	30						CTCCTGGATTCCGCCGACAGT	0.662000													12	29					7.93312e-07	9.99727e-07	0.457914	1	0
SCAF11	9169	broad.mit.edu	37	12	46342248	46342248	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:46342248A>C	ENST00000369367.3	-	5	603	c.370T>G	c.(370-372)Tgt>Ggt	p.C124G	SCAF11_ENST00000419565.2_Missense_Mutation_p.C124G	NM_004719.2	NP_004710.2	Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	124					spliceosome assembly	nucleus	protein binding|zinc ion binding	p.C124G(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TTTTCATGACAGGAGACCTGT	0.308000													14	22					0	0	0.500413	0	0
EEPD1	80820	broad.mit.edu	37	7	36338682	36338682	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:36338682G>T	ENST00000242108.4	+	8	2295	c.1577G>T	c.(1576-1578)gGg>gTg	p.G526V	EEPD1_ENST00000534978.1_Missense_Mutation_p.G526V	NM_030636.2	NP_085139.2	Q7L9B9	EEPD1_HUMAN	endonuclease/exonuclease/phosphatase family domain containing 1	526					DNA repair		DNA binding	p.G526V(1)		endometrium(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|skin(1)	18						TCTTGGGGCGGGGTGGCTTCT	0.587000													18	46					1.45105e-14	2.38413e-14	0.539581	1	0
PDZRN3	23024	broad.mit.edu	37	3	73432672	73432672	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:73432672C>A	ENST00000263666.4	-	10	3159	c.3045G>T	c.(3043-3045)atG>atT	p.M1015I	PDZRN3_ENST00000479530.1_Missense_Mutation_p.M732I|PDZRN3_ENST00000462146.2_Missense_Mutation_p.M672I|PDZRN3_ENST00000466780.1_Missense_Mutation_p.M672I|PDZRN3_ENST00000535920.1_Missense_Mutation_p.M737I	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1015							ubiquitin-protein ligase activity|zinc ion binding	p.M1015I(1)		breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		CGAGAATGTTCATCTCCTTCC	0.498000													25	218					3.65163e-15	6.07668e-15	0.706142	1	0
DNMT3A	1788	broad.mit.edu	37	2	25470539	25470539	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:25470539G>A	ENST00000264709.3	-	8	1272	c.935C>T	c.(934-936)tCt>tTt	p.S312F	DNMT3A_ENST00000402667.1_Missense_Mutation_p.S89F|DNMT3A_ENST00000380746.4_Missense_Mutation_p.S123F|DNMT3A_ENST00000321117.5_Missense_Mutation_p.S312F	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	312	Interaction with DNMT1 and DNMT3B.|PWWP.				regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding	p.S312F(1)|p.S123F(1)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CATCCACCAAGACACAATGCG	0.632000			"""Mis, F, N, S"""		AML								19	38					0	0	0.608945	0	0
ZSCAN20	7579	broad.mit.edu	37	1	33945126	33945126	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:33945126G>T	ENST00000361328.3	+	2	390	c.237G>T	c.(235-237)tgG>tgT	p.W79C	ZSCAN20_ENST00000373413.2_Missense_Mutation_p.W79C|ZSCAN20_ENST00000480917.1_3'UTR	NM_145238.3	NP_660281.2	P17040	ZSC20_HUMAN	zinc finger and SCAN domain containing 20	79	SCAN box.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.W79F(1)		breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(2)|pancreas(1)|stomach(1)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				GCTGTCGTTGGCTGAGGCCGG	0.622000													4	30					0.00024832	0.000283732	0.150653	1	0
GRXCR1	389207	broad.mit.edu	37	4	43032469	43032469	+	Missense_Mutation	SNP	G	G	T	rs146696590	by1000genomes	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:43032469G>T	ENST00000399770.2	+	4	785	c.785G>T	c.(784-786)cGa>cTa	p.R262L		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	262					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity	p.R262L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						TCCATGTTTCGAAACTGCTTC	0.468000													50	99					3.94638e-17	6.86648e-17	0.870114	1	0
OR4M2	390538	broad.mit.edu	37	15	22369380	22369380	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:22369380C>A	ENST00000332663.2	+	1	903	c.805C>A	c.(805-807)Cta>Ata	p.L269I	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L269I(1)		NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTCGTTTTCCCTAGATAAAGT	0.418000													24	155					9.57634e-11	1.41573e-10	0.654019	1	0
KIAA1324	57535	broad.mit.edu	37	1	109737059	109737059	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:109737059A>G	ENST00000369939.3	+	15	2147	c.1964A>G	c.(1963-1965)tAc>tGc	p.Y655C	KIAA1324_ENST00000529753.1_Missense_Mutation_p.Y568C|KIAA1324_ENST00000369938.1_3'UTR	NM_020775.4	NP_065826.2	Q6UXG2	K1324_HUMAN	KIAA1324	655					macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane		p.Y655C(1)		NS(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(9)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		TCTCTGTGCTACAACGATTGC	0.577000													3	29					0	0	0.217242	0	0
C17orf47	284083	broad.mit.edu	37	17	56620524	56620524	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:56620524G>T	ENST00000321691.3	-	1	1205	c.1024C>A	c.(1024-1026)Cag>Aag	p.Q342K	RP11-112H10.4_ENST00000580769.1_RNA|RP11-112H10.4_ENST00000580589.1_RNA|RP11-112H10.4_ENST00000578022.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	342								p.Q342K(1)		NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCTACTGACTGTACCCCTGGG	0.532000													8	34					0.00307968	0.00333119	0.278610	1	0
SV2A	9900	broad.mit.edu	37	1	149884838	149884838	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:149884838C>T	ENST00000369146.3	-	2	1045	c.555G>A	c.(553-555)gtG>gtA	p.V185V	SV2A_ENST00000369145.1_Silent_p.V185V	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	185					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity	p.V185V(1)		breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CGAAGCCCACCACAAAGACCT	0.582000													20	73					0	0	0.592651	0	0
AHR	196	broad.mit.edu	37	7	17374516	17374516	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:17374516G>A	ENST00000242057.4	+	8	1557	c.914G>A	c.(913-915)aGa>aAa	p.R305K		NM_001621.4	NP_001612.1	P35869	AHR_HUMAN	aryl hydrocarbon receptor	305	PAS 2.				apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding	p.R305K(2)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(11)|ovary(1)|pancreas(1)|urinary_tract(3)	33	Lung NSC(10;0.0392)|all_lung(11;0.0754)					AACAGAGGAAGAATTGTTTTA	0.333000													3	88					0	0	0.115264	0	0
MOGS	7841	broad.mit.edu	37	2	74689728	74689728	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:74689728G>A	ENST00000233616.4	-	4	1350	c.1188C>T	c.(1186-1188)agC>agT	p.S396S	MOGS_ENST00000409065.1_3'UTR|MOGS_ENST00000452063.2_Silent_p.S290S	NM_006302.2	NP_006293.2	Q13724	MOGS_HUMAN	mannosyl-oligosaccharide glucosidase	396					oligosaccharide metabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|membrane fraction	mannosyl-oligosaccharide glucosidase activity	p.S396S(1)		cervix(1)|endometrium(6)|large_intestine(3)|lung(10)|prostate(1)|urinary_tract(2)	23						CAAGGAGGCCGCTGAGGGCAG	0.582000													9	166					0	0	0.361761	0	0
CDHR2	54825	broad.mit.edu	37	5	176002154	176002154	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:176002154G>C	ENST00000510636.1	+	8	839	c.565G>C	c.(565-567)Ggc>Cgc	p.G189R	CDHR2_ENST00000506348.1_Missense_Mutation_p.G189R|CDHR2_ENST00000261944.5_Missense_Mutation_p.G189R	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	189	Cadherin 2.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding	p.G189R(1)		breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						AGTCCTCAATGGCAGCCTCAG	0.627000													26	61					0	0	0.706142	0	0
LRRC73	221424	broad.mit.edu	37	6	43476063	43476063	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:43476063C>A	ENST00000372441.1	-	3	1429	c.529G>T	c.(529-531)Gtc>Ttc	p.V177F		NM_001012974.1	NP_001012992.1	Q5JTD7	CF154_HUMAN	leucine rich repeat containing 73	177								p.V177F(1)									AGATTGAGGACGCGGACCTGG	0.607000													18	25					3.32936e-07	4.25345e-07	0.539581	1	0
UGT1A3	54659	broad.mit.edu	37	2	234637908	234637908	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:234637908G>C	ENST00000482026.1	+	1	155	c.136G>C	c.(136-138)Gag>Cag	p.E46Q	UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A7_ENST00000373426.3_Intron	NM_019093.2	NP_061966.1												p.E46Q(1)		breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CAGCATGCGGGAGGTCTTGCG	0.582000													14	36					0	0	0.500413	0	0
ZNF536	9745	broad.mit.edu	37	19	31038886	31038886	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:31038886C>A	ENST00000355537.3	+	4	2507	c.2360C>A	c.(2359-2361)gCc>gAc	p.A787D		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	787					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.A787D(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					TGTGACTATGCCGGCACGCAG	0.512000													36	233					4.0492e-12	6.22732e-12	0.827153	1	0
TMPRSS11E	28983	broad.mit.edu	37	4	69342097	69342097	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:69342097C>T	ENST00000305363.4	+	7	712	c.648C>T	c.(646-648)cgC>cgT	p.R216R		NM_014058.3	NP_054777.2	Q9UL52	TM11E_HUMAN	transmembrane protease, serine 11E	216	Peptidase S1.				proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity	p.R216R(1)		endometrium(1)|lung(19)|pancreas(1)|skin(3)	24						GGAGTCATCGCTGTGGAGCAA	0.488000													19	35					0	0	0.575678	0	0
BEST3	144453	broad.mit.edu	37	12	70049458	70049458	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:70049458G>T	ENST00000330891.5	-	10	1462	c.1236C>A	c.(1234-1236)agC>agA	p.S412R	BEST3_ENST00000553096.1_Missense_Mutation_p.S306R|BEST3_ENST00000331471.4_Intron|BEST3_ENST00000488961.1_Missense_Mutation_p.S199R	NM_032735.2	NP_116124.2	Q8N1M1	BEST3_HUMAN	bestrophin 3	412						chloride channel complex|plasma membrane	chloride channel activity	p.S199R(1)|p.S412R(1)		cervix(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(2)	12	Breast(13;2.31e-06)|Esophageal squamous(21;0.187)		Lung(24;0.000278)|OV - Ovarian serous cystadenocarcinoma(12;0.0019)|STAD - Stomach adenocarcinoma(21;0.00694)			GCCTCCTGTAGCTTCTTCTTC	0.562000													28	34					4.22769e-11	6.35133e-11	0.706142	1	0
OR10Z1	128368	broad.mit.edu	37	1	158577102	158577102	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:158577102C>A	ENST00000361284.1	+	1	874	c.874C>A	c.(874-876)Cta>Ata	p.L292I		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	292					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L292I(1)		endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					TGTTTATAGTCTAAGGAATAG	0.463000													101	167					2.54621e-43	4.97738e-43	0.870114	1	0
UXS1	80146	broad.mit.edu	37	2	106761803	106761803	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:106761803C>A	ENST00000283148.7	-	6	412	c.315G>T	c.(313-315)gtG>gtT	p.V105V	UXS1_ENST00000540130.1_Silent_p.V43V|UXS1_ENST00000479621.1_5'UTR|UXS1_ENST00000428048.2_Intron|UXS1_ENST00000409501.3_Silent_p.V100V	NM_001253875.1|NM_025076.4	NP_001240804.1|NP_079352.2	Q8NBZ7	UXS1_HUMAN	UDP-glucuronate decarboxylase 1	100					cellular metabolic process	Golgi cisterna membrane|integral to membrane	coenzyme binding|UDP-glucuronate decarboxylase activity	p.G101C(1)|p.G106C(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	17						GATGGGAGCCCACGAACCCTG	0.557000													9	21					0.0477658	0.0492845	0.307466	1	0
ATP2B4	493	broad.mit.edu	37	1	203669926	203669926	+	Splice_Site	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:203669926G>T	ENST00000357681.5	+	6	1899	c.775_splice	c.e6-1	p.G259_splice	ATP2B4_ENST00000341360.2_Splice_Site_p.G259_splice|ATP2B4_ENST00000367218.3_Splice_Site_p.G259_splice|ATP2B4_ENST00000367219.3_Splice_Site_p.G259_splice|ATP2B4_ENST00000391954.2_Splice_Site_p.G259_splice	NM_001684.4	NP_001675.3	P23634	AT2B4_HUMAN	ATPase, Ca++ transporting, plasma membrane 4	259					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding	p.G259V(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(10)|lung(20)|ovary(2)|prostate(6)|skin(1)|stomach(1)|urinary_tract(3)	56	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TCCCGTGTAGGGACCCATGTC	0.453000													7	40					0.00198382	0.00216751	0.248553	1	0
PAK6	56924	broad.mit.edu	37	15	40564712	40564712	+	Silent	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:40564712A>T	ENST00000455577.2	+	6	2058	c.1146A>T	c.(1144-1146)acA>acT	p.T382T	RP11-133K1.2_ENST00000558658.1_3'UTR|PAK6_ENST00000453867.1_Silent_p.T382T|PAK6_ENST00000260404.4_Silent_p.T382T|PAK6_ENST00000542403.2_Silent_p.T382T|PAK6_ENST00000441369.1_Silent_p.T382T|PAK6_ENST00000560346.1_Silent_p.T382T	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	382	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity	p.T382T(1)		breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		GTGAGGACACAGGTGTTGTGA	0.647000													5	18					0	0	0.217242	0	0
COPG2	26958	broad.mit.edu	37	7	130295897	130295897	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:130295897C>G	ENST00000445977.2	-	9	753	c.664G>C	c.(664-666)Ggt>Cgt	p.G222R				Q9UBF2	COPG2_HUMAN	coatomer protein complex, subunit gamma 2	222					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat	protein binding|structural molecule activity	p.G222R(1)		large_intestine(1)	1	Melanoma(18;0.0435)					GACTTGAGACCAGATTTAGTA	0.403000													14	46					0	0	0.435327	0	0
NPR1	4881	broad.mit.edu	37	1	153660630	153660630	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:153660630T>C	ENST00000368680.3	+	15	2822	c.2350T>C	c.(2350-2352)Tgg>Cgg	p.W784R		NM_000906.3	NP_000897.3	P16066	ANPRA_HUMAN	natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)	784	Protein kinase.				body fluid secretion|intracellular signal transduction|negative regulation of angiogenesis|negative regulation of cell growth|positive regulation of renal sodium excretion|positive regulation of urine volume|receptor guanylyl cyclase signaling pathway|regulation of blood pressure|regulation of blood vessel size|regulation of vascular permeability|regulation of vasodilation		ATP binding|GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|peptide receptor activity, G-protein coupled|protein kinase activity	p.W784R(1)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(17)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)		Erythrityl Tetranitrate(DB01613)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Nesiritide(DB04899)|Nitric Oxide(DB00435)|Nitroglycerin(DB00727)|Nitroprusside(DB00325)	GCAGCGGTGCTGGGCTGAGGA	0.642000													33	61					0	0	0.779181	0	0
NR1H3	10062	broad.mit.edu	37	11	47282972	47282972	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:47282972G>T	ENST00000467728.1	+	4	1918	c.680G>T	c.(679-681)cGc>cTc	p.R227L	NR1H3_ENST00000395397.3_Missense_Mutation_p.R182L|NR1H3_ENST00000527949.1_Missense_Mutation_p.R136L|NR1H3_ENST00000441012.2_Missense_Mutation_p.R227L|NR1H3_ENST00000405853.3_Missense_Mutation_p.R227L|NR1H3_ENST00000405576.1_Missense_Mutation_p.R182L|NR1H3_ENST00000481889.2_Missense_Mutation_p.R182L|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000407404.1_Missense_Mutation_p.R227L			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	227	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding	p.R227L(1)		endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						TGTAACCGGCGCTCCTTTTCT	0.617000													13	23					2.31682e-05	2.75388e-05	0.479597	1	0
WDR7	23335	broad.mit.edu	37	18	54363593	54363593	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr18:54363593C>T	ENST00000254442.3	+	12	1689	c.1478C>T	c.(1477-1479)tCa>tTa	p.S493L	WDR7_ENST00000589935.1_Intron|WDR7_ENST00000357574.3_Missense_Mutation_p.S493L	NM_015285.2	NP_056100.2	Q9Y4E6	WDR7_HUMAN	WD repeat domain 7	493								p.S493L(1)		NS(1)|breast(5)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(37)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	78				Lung(128;0.0238)|Colorectal(16;0.0296)		GTGGATTTTTCAGTCATAATT	0.403000													4	57					0	0	0.184627	0	0
ADA	100	broad.mit.edu	37	20	43248977	43248977	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:43248977G>T	ENST00000372874.4	-	11	1175	c.1041C>A	c.(1039-1041)ctC>ctA	p.L347L	ADA_ENST00000537820.1_Silent_p.L323L|PKIG_ENST00000372887.1_Intron|PKIG_ENST00000372882.3_Intron|ADA_ENST00000464097.1_5'UTR	NM_000022.2	NP_000013.2	P00813	ADA_HUMAN	adenosine deaminase	347					adenosine catabolic process|cell adhesion|hypoxanthine salvage|inosine biosynthetic process|negative regulation of adenosine receptor signaling pathway|purine nucleotide salvage|purine ribonucleoside monophosphate biosynthetic process|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation	cell junction|cytoplasmic membrane-bounded vesicle lumen|cytosol|external side of plasma membrane|lysosome	adenosine deaminase activity|protein binding|zinc ion binding	p.L347L(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(2)|prostate(3)|skin(2)|urinary_tract(1)	18		all_lung(126;1.24e-07)|Lung NSC(126;1.94e-07)|Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)		Adenosine(DB00640)|Cladribine(DB00242)|Dipyridamole(DB00975)|Erythromycin(DB00199)|Fludarabine(DB01073)|Idoxuridine(DB00249)|Nelarabine(DB01280)|Pentostatin(DB00552)|Theophylline(DB00277)|Vidarabine(DB00194)	AGGCTTTATAGAGCAGGTCGA	0.537000									Adenosine Deaminase Deficiency				21	48					1.10513e-12	1.71177e-12	0.624587	1	0
CDK9	1025	broad.mit.edu	37	9	130550579	130550579	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:130550579C>T	ENST00000373265.2	+	5	870	c.870C>T	c.(868-870)gcC>gcT	p.A290A	CDK9_ENST00000480353.1_3'UTR|CDK9_ENST00000373264.4_Silent_p.A173A			P50750	CDK9_HUMAN	cyclin-dependent kinase 9	173	Protein kinase.				cell proliferation|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	transcription elongation factor complex	ATP binding|cyclin-dependent protein kinase activity|DNA binding|protein binding|RNA polymerase II carboxy-terminal domain kinase activity	p.A173A(1)		lung(1)	1						TGGCCCGGGCCTTCAGCCTGG	0.612000													5	19					0	0	0.184627	0	0
MIR646HG	284757	broad.mit.edu	37	20	58883586	58883586	+	RNA	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:58883586G>C	ENST00000432910.1	+	0	332				MIR646_ENST00000385067.1_RNA	NR_046099.1																						gtgatcccaggagaggaagca	0.572000													7	11					0	0	0.278610	0	0
RYR3	6263	broad.mit.edu	37	15	34113753	34113753	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:34113753C>A	ENST00000389232.4	+	80	11015	c.10945C>A	c.(10945-10947)Ctg>Atg	p.L3649M	RYR3_ENST00000415757.3_Missense_Mutation_p.L3644M	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	3649					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.L3648M(1)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGTTGAGACGCTGAAGCTGGG	0.552000													5	22					0.00116845	0.00129406	0.217242	1	0
AJAP1	55966	broad.mit.edu	37	1	4829965	4829965	+	Silent	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:4829965A>T	ENST00000378191.4	+	3	1263	c.882A>T	c.(880-882)atA>atT	p.I294I	AJAP1_ENST00000378190.3_Silent_p.I294I	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	294					cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane		p.I294I(1)		endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		TCATGGTCATAGCTGCTCTCA	0.527000													17	79					0	0	0.557998	0	0
KRT71	112802	broad.mit.edu	37	12	52941958	52941958	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:52941958G>T	ENST00000267119.5	-	5	1025	c.956C>A	c.(955-957)gCt>gAt	p.A319D		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	319	Coil 2.|Rod.						structural molecule activity	p.A319D(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CAGGGCCTCAGCCTCGGCCTT	0.577000													6	35					0.00307968	0.00333119	0.278610	1	0
POLR1D	51082	broad.mit.edu	37	13	28240074	28240074	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:28240074G>T	ENST00000399697.3	+	3	471	c.353G>T	c.(352-354)cGg>cTg	p.R118L	POLR1D_ENST00000465887.1_3'UTR	NM_001206559.1|NM_152705.2	NP_001193488.1|NP_689918.1	Q9Y2S0	RPAC2_HUMAN	polymerase (RNA) I polypeptide D, 16kDa	0					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity	p.R118L(1)		endometrium(1)|large_intestine(1)|lung(4)|stomach(2)	8		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.0758)|OV - Ovarian serous cystadenocarcinoma(117;0.1)|Epithelial(112;0.213)		TACGAAAAGCGGTCCAACCGG	0.652000													11	24					2.68362e-12	4.13698e-12	0.411799	1	0
USH2A	7399	broad.mit.edu	37	1	215848721	215848721	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:215848721G>C	ENST00000366943.2	-	63	12918	c.12532C>G	c.(12532-12534)Cct>Gct	p.P4178A	USH2A_ENST00000307340.3_Missense_Mutation_p.P4178A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4178	Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.P4178A(1)|p.P4178T(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGGTTAACAGGCTCAGACCAG	0.507000										HNSCC(13;0.011)			8	38					0	0	0.278610	0	0
MAP3K4	4216	broad.mit.edu	37	6	161470454	161470454	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:161470454A>G	ENST00000392142.4	+	3	1298	c.1150A>G	c.(1150-1152)Aaa>Gaa	p.K384E	MAP3K4_ENST00000366920.2_Missense_Mutation_p.K384E|MAP3K4_ENST00000348824.7_Missense_Mutation_p.K384E|MAP3K4_ENST00000366919.2_Missense_Mutation_p.K384E	NM_005922.2	NP_005913.2	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	384					activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding	p.K384E(2)		breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(28)|ovary(3)|skin(2)|stomach(1)	77		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		ATATGCTGCAAAAGACTTCCA	0.403000													11	38					0	0	0.361761	0	0
TGFBI	7045	broad.mit.edu	37	5	135390481	135390481	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:135390481G>A	ENST00000442011.2	+	10	1502	c.1341G>A	c.(1339-1341)aaG>aaA	p.K447K	TGFBI_ENST00000305126.8_Silent_p.K447K	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	447	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding	p.K447K(1)		breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			TGGCCTCTAAGTATCTGTACC	0.448000													7	160					0	0	0.278610	0	0
OSM	5008	broad.mit.edu	37	22	30660402	30660402	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr22:30660402G>T	ENST00000215781.2	-	3	269	c.229C>A	c.(229-231)Cgc>Agc	p.R77S	OSM_ENST00000403389.1_Missense_Mutation_p.R56S|OSM_ENST00000403463.1_3'UTR	NM_020530.4	NP_065391.1	P13725	ONCM_HUMAN	oncostatin M	77					cell proliferation|immune response|negative regulation of cell proliferation|negative regulation of hormone secretion|positive regulation of cell division|positive regulation of cell proliferation|positive regulation of MAPKKK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of transcription from RNA polymerase II promoter|regulation of growth	extracellular space|oncostatin-M receptor complex	cytokine activity|growth factor activity|oncostatin-M receptor binding	p.R77S(1)		breast(1)|endometrium(2)|large_intestine(2)|lung(3)|skin(3)	11			Epithelial(10;0.206)			GCCCCGGGGCGCTCCCTGCAG	0.632000													7	17					8.12818e-05	9.52201e-05	0.248553	1	0
NUP205	23165	broad.mit.edu	37	7	135261743	135261743	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:135261743G>T	ENST00000285968.6	+	5	541	c.515G>T	c.(514-516)cGc>cTc	p.R172L	NUP205_ENST00000440390.2_5'UTR	NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	172					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.R172L(1)		breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						ATGACAACACGCTTTACAGAT	0.363000													28	27					2.85442e-18	4.9933e-18	0.750413	1	0
C3orf20	84077	broad.mit.edu	37	3	14763190	14763190	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:14763190G>T	ENST00000253697.3	+	10	1917	c.1465G>T	c.(1465-1467)Gga>Tga	p.G489*	C3orf20_ENST00000495387.1_3'UTR|C3orf20_ENST00000412910.1_Nonsense_Mutation_p.G367*|C3orf20_ENST00000435614.1_Nonsense_Mutation_p.G367*	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	489						cytoplasm|integral to membrane		p.G489*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						AAAGGTACTGGGACAGGACTC	0.502000													38	69					2.09667e-21	3.85478e-21	0.788014	1	0
PXDN	7837	broad.mit.edu	37	2	1642638	1642638	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:1642638T>C	ENST00000252804.4	-	21	4236	c.4186A>G	c.(4186-4188)Atc>Gtc	p.I1396V		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1396					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity	p.I1396V(1)		breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		AGGTCTGTGATGGTCTTCTGC	0.557000													10	34					0	0	0.457914	0	0
TDRD7	23424	broad.mit.edu	37	9	100222868	100222868	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:100222868G>T	ENST00000355295.4	+	7	1559	c.1264G>T	c.(1264-1266)Ggt>Tgt	p.G422C	TDRD7_ENST00000422139.2_Missense_Mutation_p.G348C	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	422	Lotus/OST-HTH 3.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding	p.G422C(1)		endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				GCAAGCACATGGTGATAATGA	0.418000													25	49					3.65163e-15	6.07668e-15	0.706142	1	0
TLE3	7090	broad.mit.edu	37	15	70358421	70358421	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:70358421C>A	ENST00000558939.1	-	7	1886	c.509G>T	c.(508-510)gGc>gTc	p.G170V	TLE3_ENST00000558379.1_Missense_Mutation_p.G170V|TLE3_ENST00000560939.1_Missense_Mutation_p.G175V|TLE3_ENST00000557907.1_Missense_Mutation_p.G170V|TLE3_ENST00000440567.3_Missense_Mutation_p.G163V|TLE3_ENST00000317509.8_Missense_Mutation_p.G170V|TLE3_ENST00000557997.1_Missense_Mutation_p.G170V|TLE3_ENST00000442299.2_Missense_Mutation_p.G170V|TLE3_ENST00000451782.2_Missense_Mutation_p.G170V|TLE3_ENST00000559048.1_Missense_Mutation_p.G175V|TLE3_ENST00000539550.1_Missense_Mutation_p.G114V|TLE3_ENST00000560589.1_Missense_Mutation_p.G114V|TLE3_ENST00000558201.1_Missense_Mutation_p.G176V|TLE3_ENST00000559191.1_Intron|TLE3_ENST00000559929.1_Missense_Mutation_p.G180V			Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	170	Gly/Pro-rich.				organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding	p.G170V(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GCCCAGGGCGCCCAGTGCCAG	0.682000													9	18					4.68919e-08	6.17299e-08	0.361761	1	0
LRP1B	53353	broad.mit.edu	37	2	141986816	141986816	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:141986816G>C	ENST00000389484.3	-	6	1757	c.786C>G	c.(784-786)atC>atG	p.I262M		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	262					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.I262M(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTGTTATCTGGATACATTTGA	0.303000										TSP Lung(27;0.18)			24	52					0	0	0.624587	0	0
GBP5	115362	broad.mit.edu	37	1	89730567	89730567	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:89730567C>G	ENST00000343435.5	-	8	1487	c.951G>C	c.(949-951)ttG>ttC	p.L317F	RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000370459.3_Missense_Mutation_p.L317F|GBP5_ENST00000481145.1_5'UTR	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	317						plasma membrane	GTP binding|GTPase activity	p.L317F(1)		breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		CTCTCTGAGCCAAGGCCAGGA	0.522000													28	33					0	0	0.681144	0	0
FIBCD1	84929	broad.mit.edu	37	9	133779435	133779435	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:133779435G>T	ENST00000253018.4	-	6	1215	c.497C>A	c.(496-498)tCc>tAc	p.S166Y	FIBCD1_ENST00000372338.4_3'UTR|FIBCD1_ENST00000372337.2_3'UTR|FIBCD1_ENST00000448616.1_3'UTR			Q8N539	FBCD1_HUMAN	fibrinogen C domain containing 1	36					signal transduction	extracellular space|integral to membrane	chitin binding|metal ion binding|receptor binding			kidney(1)|large_intestine(3)|lung(2)|prostate(5)|urinary_tract(1)	12	all_hematologic(7;0.0028)			OV - Ovarian serous cystadenocarcinoma(145;3.52e-05)|Epithelial(140;0.00019)		CAGGGCCAAGGACAAGGTGCA	0.627000													9	14					9.70103e-10	1.38984e-09	0.361761	1	0
MRC1	4360	broad.mit.edu	37	10	17891603	17891603	+	Missense_Mutation	SNP	T	T	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:17891603T>G	ENST00000331429.2	+	7	1187	c.1084T>G	c.(1084-1086)Tgt>Ggt	p.C362G	MRC1L1_ENST00000457317.1_Missense_Mutation_p.C362G														p.C362G(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCCTACTCACTGTCCTAGTCA	0.383000													18	87					0	0	0.693898	0	0
MAP4K1	11184	broad.mit.edu	37	19	39101766	39101766	+	Silent	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:39101766A>T	ENST00000591517.1	-	11	763	c.735T>A	c.(733-735)gcT>gcA	p.A245A	MAP4K1_ENST00000396857.2_Silent_p.A245A|MAP4K1_ENST00000423454.2_Intron|MAP4K1_ENST00000586296.1_Silent_p.A245A|MAP4K1_ENST00000589130.1_Silent_p.A241A|MAP4K1_ENST00000589002.1_Intron	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	245	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity	p.A245A(2)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TGTGGAAGGCAGCCGACCTTG	0.582000													9	30					0	0	0.307466	0	0
WBSCR17	64409	broad.mit.edu	37	7	70880936	70880936	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:70880936G>T	ENST00000333538.5	+	4	1285	c.651G>T	c.(649-651)gtG>gtT	p.V217V	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	217	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.V218L(1)|p.V217V(1)		NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				TGGTGAAGGTGGTAAGAAATC	0.532000													11	25					7.03913e-09	9.69935e-09	0.411799	1	0
ZNF716	441234	broad.mit.edu	37	7	57522855	57522855	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:57522855G>T	ENST00000420713.1	+	3	355	c.243G>T	c.(241-243)gaG>gaT	p.E81D		NM_001159279.1	NP_001152751.1			zinc finger protein 716									p.E81D(2)		breast(1)|kidney(1)|lung(20)|ovary(2)	24						AGAGAAATGAGATGGTAGCCA	0.413000													15	63					0.00244969	0.00267202	0.457914	1	0
LIX1	167410	broad.mit.edu	37	5	96460280	96460280	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:96460280C>T	ENST00000274382.4	-	2	431	c.136G>A	c.(136-138)Gct>Act	p.A46T	CTD-2215E18.1_ENST00000509481.1_Intron	NM_153234.4	NP_694966.3	Q8N485	LIX1_HUMAN	Lix1 homolog (chicken)	46								p.A46T(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)	10		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		GGGAATGCAGCCTTCTGCTGC	0.483000													10	17					0	0	0.361761	0	0
ZFP14	57677	broad.mit.edu	37	19	36831324	36831324	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:36831324G>A	ENST00000270001.7	-	5	1519	c.1404C>T	c.(1402-1404)acC>acT	p.T468T		NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T468T(1)		NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					TCTGATGTTGGGTAAGTTGTG	0.373000													50	63					0	0	0.870114	0	0
IGKV1D-8	28904	broad.mit.edu	37	2	90259791	90259791	+	RNA	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:90259791C>T	ENST00000471857.1	+	0	199																											TGAGGGTCCCCGCTCAGCTCC	0.557000													4	150					0	0	0.217242	0	0
ITGAD	3681	broad.mit.edu	37	16	31422671	31422671	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:31422671G>T	ENST00000389202.2	+	14	1589	c.1540G>T	c.(1540-1542)Ggc>Tgc	p.G514C		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	514					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity	p.G514C(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						TGGTGAGCAGGGCCACCCCTG	0.627000													43	97					1.68508e-10	2.44658e-10	0.847076	1	0
C20orf85	128602	broad.mit.edu	37	20	56728599	56728599	+	Splice_Site	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:56728599G>T	ENST00000371168.3	+	2	129		c.e2-1			NM_178456.2	NP_848551.1	Q9H1P6	CT085_HUMAN	chromosome 20 open reading frame 85									p.?(1)		kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	13	all_epithelial(3;5.99e-14)|Lung NSC(12;0.000152)|all_lung(29;0.000518)|Melanoma(10;0.118)		BRCA - Breast invasive adenocarcinoma(13;5.53e-12)|Epithelial(14;7.42e-08)|all cancers(14;7.19e-07)			TTCTTTTTCAGGAAATACCGT	0.478000													47	84					2.81731e-22	5.26926e-22	0.870114	1	0
OSBPL5	114879	broad.mit.edu	37	11	3123481	3123481	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:3123481C>G	ENST00000263650.7	-	12	1516	c.1357G>C	c.(1357-1359)Ggg>Cgg	p.G453R	OSBPL5_ENST00000542243.1_Missense_Mutation_p.G84R|OSBPL5_ENST00000525498.1_Missense_Mutation_p.G364R|OSBPL5_ENST00000348039.5_Missense_Mutation_p.G385R|OSBPL5_ENST00000389989.3_Missense_Mutation_p.G385R	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	453					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding	p.G453R(1)		breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		AAGGTCTCCCCCAGGATGGGG	0.597000													3	1					0	0	0.115264	0	0
OR11G2	390439	broad.mit.edu	37	14	20666456	20666456	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:20666456C>A	ENST00000357366.3	+	1	962	c.962C>A	c.(961-963)cCa>cAa	p.P321Q		NM_001005503.1	NP_001005503.1	Q8NGC1	O11G2_HUMAN	olfactory receptor, family 11, subfamily G, member 2	321					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P321Q(1)		endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	22	all_cancers(95;0.00108)		Epithelial(56;9.76e-07)|all cancers(55;5.61e-06)	GBM - Glioblastoma multiforme(265;0.0144)		gttgttaccccactgcttaac	0.403000													23	58					1.10923e-09	1.57871e-09	0.639603	1	0
NOL8	55035	broad.mit.edu	37	9	95062203	95062203	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:95062203C>T	ENST00000545558.1	-	14	3763	c.3271G>A	c.(3271-3273)Gaa>Aaa	p.E1091K	NOL8_ENST00000442668.2_Missense_Mutation_p.E1091K|NOL8_ENST00000535387.1_Missense_Mutation_p.E1053K|NOL8_ENST00000542053.1_Missense_Mutation_p.E1023K|NOL8_ENST00000358855.4_Missense_Mutation_p.E1023K			Q76FK4	NOL8_HUMAN	nucleolar protein 8	1091					DNA replication|positive regulation of cell growth	nucleolus	nucleotide binding|protein binding|RNA binding			endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)	16						TCTGTTTCTTCAGTAACATCT	0.378000													5	209					0	0	0.184627	0	0
FBXL7	23194	broad.mit.edu	37	5	15928579	15928579	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:15928579C>A	ENST00000504595.1	+	3	1189	c.708C>A	c.(706-708)ctC>ctA	p.L236L	FBXL7_ENST00000329673.7_Silent_p.L224L|FBXL7_ENST00000510662.1_Silent_p.L189L	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	236					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity	p.L236L(1)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						TGGTGTCCCTCTGCCCTAATC	0.562000													22	90					1.37878e-21	2.55665e-21	0.654019	1	0
CYYR1	116159	broad.mit.edu	37	21	27945363	27945363	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:27945363C>A	ENST00000435845.2	-	1	240	c.221G>T	c.(220-222)cGg>cTg	p.R74L	CYYR1_ENST00000299340.4_5'UTR|CYYR1_ENST00000400043.3_5'UTR			Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	0						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						TCCTGAGAGCCGGGTGGAGCA	0.711000													6	8					0.0215528	0.0223804	0.217242	1	0
APBA2	321	broad.mit.edu	37	15	29346220	29346220	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:29346220G>T	ENST00000558402.1	+	5	732	c.133G>T	c.(133-135)Ggc>Tgc	p.G45C	APBA2_ENST00000558259.1_Missense_Mutation_p.G45C|APBA2_ENST00000561069.1_Missense_Mutation_p.G45C|APBA2_ENST00000411764.1_Missense_Mutation_p.G45C|APBA2_ENST00000558330.1_Missense_Mutation_p.G45C			Q99767	APBA2_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 2	45					nervous system development|protein transport		protein binding	p.G45C(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|liver(2)|lung(33)|stomach(1)|urinary_tract(1)	59		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		TGTGCCCGAGGGCCTGGAGCT	0.657000													5	34					0.000602214	0.000671541	0.184627	1	0
CHRDL1	91851	broad.mit.edu	37	X	109919543	109919543	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:109919543C>G	ENST00000218054.4	-	12	1483	c.1287G>C	c.(1285-1287)atG>atC	p.M429I	CHRDL1_ENST00000482160.1_Missense_Mutation_p.M351I|CHRDL1_ENST00000394797.4_Missense_Mutation_p.M429I|CHRDL1_ENST00000372045.1_Missense_Mutation_p.M423I|CHRDL1_ENST00000434224.1_Missense_Mutation_p.M350I|CHRDL1_ENST00000444321.2_Missense_Mutation_p.M430I|CHRDL1_ENST00000372042.1_Missense_Mutation_p.M431I	NM_001143981.1|NM_001143982.1|NM_145234.3	NP_001137453.1|NP_001137454.1|NP_660277.2	Q9BU40	CRDL1_HUMAN	chordin-like 1	423					BMP signaling pathway|cell differentiation|nervous system development|ossification	extracellular region		p.M429I(1)		endometrium(1)|large_intestine(12)|liver(1)|lung(15)|prostate(1)|skin(1)	31						GACTTGAACACATCTGGCTGA	0.473000													6	34					0	0	0.248553	0	0
OR10J5	127385	broad.mit.edu	37	1	159505015	159505015	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:159505015C>T	ENST00000334857.2	-	1	827	c.783G>A	c.(781-783)ccG>ccA	p.P261P		NM_001004469.1	NP_001004469.1	Q8NHC4	O10J5_HUMAN	olfactory receptor, family 10, subfamily J, member 5	261					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P261P(2)		kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	22	all_hematologic(112;0.0429)					TTTCTGACTTCGGCTTGAGGT	0.502000													3	68					0	0	0.150653	0	0
CYLC1	1538	broad.mit.edu	37	X	83129059	83129059	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:83129059C>A	ENST00000329312.4	+	4	1380	c.1343C>A	c.(1342-1344)tCt>tAt	p.S448Y		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	448					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity	p.S447Y(1)|p.S448Y(1)		NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						GATGCTGACTCTGAACCGAAG	0.338000													5	6					0.0215528	0.0223804	0.217242	1	0
COLQ	8292	broad.mit.edu	37	3	15531040	15531040	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:15531040G>T	ENST00000383785.2	-	2	336	c.211C>A	c.(211-213)Cga>Aga	p.R71R	COLQ_ENST00000383786.5_Silent_p.R71R|COLQ_ENST00000383781.4_Silent_p.R61R|COLQ_ENST00000383787.2_Silent_p.R71R|COLQ_ENST00000603808.1_Silent_p.R71R|COLQ_ENST00000383788.5_Silent_p.R71R|COLQ_ENST00000435459.2_Silent_p.R61R			Q9Y215	COLQ_HUMAN	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	71					acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft		p.R71R(1)|p.R61R(1)		endometrium(2)|large_intestine(4)|lung(10)|skin(3)	19						ACCGGACTTCGGCCACCTCTG	0.582000													14	27					1.05317e-09	1.50221e-09	0.457914	1	0
RANBP9	10048	broad.mit.edu	37	6	13644892	13644892	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:13644892G>C	ENST00000011619.3	-	6	1055	c.997C>G	c.(997-999)Cct>Gct	p.P333A	RANBP9_ENST00000539980.1_Missense_Mutation_p.P104A	NM_005493.2	NP_005484.2	Q96S59	RANB9_HUMAN	RAN binding protein 9	333	B30.2/SPRY.				axon guidance|microtubule nucleation|protein complex assembly	cytosol|microtubule associated complex|nucleus	Ran GTPase binding	p.P333A(1)		breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|skin(1)	16	Breast(50;0.00669)|Ovarian(93;0.0634)	all_hematologic(90;0.117)	Epithelial(50;0.223)			AACACGAAAGGATGTTGCCCA	0.423000													22	82					0	0	0.624587	0	0
ZMYND8	23613	broad.mit.edu	37	20	45850047	45850047	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:45850047C>A	ENST00000311275.7	-	20	3528	c.3275G>T	c.(3274-3276)aGc>aTc	p.S1092I	ZMYND8_ENST00000352431.2_Missense_Mutation_p.S1066I|ZMYND8_ENST00000540497.1_Missense_Mutation_p.S1040I|ZMYND8_ENST00000536340.1_Missense_Mutation_p.S1119I|ZMYND8_ENST00000396281.4_Missense_Mutation_p.S1092I|ZMYND8_ENST00000355972.4_Missense_Mutation_p.S1092I|ZMYND8_ENST00000458360.2_Missense_Mutation_p.S960I|ZMYND8_ENST00000262975.4_Missense_Mutation_p.S1046I|ZMYND8_ENST00000360911.3_Missense_Mutation_p.S1041I|ZMYND8_ENST00000372023.3_Missense_Mutation_p.S1014I|ZMYND8_ENST00000461685.1_Missense_Mutation_p.S1066I|ZMYND8_ENST00000446994.2_Missense_Mutation_p.S983I|ZMYND8_ENST00000471951.2_Missense_Mutation_p.S1112I			Q9ULU4	PKCB1_HUMAN	zinc finger, MYND-type containing 8	1092	Poly-Ser.						protein binding|zinc ion binding	p.S1066N(1)|p.S1066I(1)		NS(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|prostate(3)|skin(2)|urinary_tract(8)	62			Epithelial(1;0.0289)|all cancers(1;0.0962)|OV - Ovarian serous cystadenocarcinoma(1;0.154)			TGATTGTGTGCTCGAGGAGCT	0.557000													18	41					2.48551e-13	3.90579e-13	0.520397	1	0
SLITRK2	84631	broad.mit.edu	37	X	144904367	144904367	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:144904367G>T	ENST00000370490.1	+	1	4679	c.424G>T	c.(424-426)Gac>Tac	p.D142Y	SLITRK2_ENST00000434188.2_Missense_Mutation_p.D142Y|SLITRK2_ENST00000428560.2_Missense_Mutation_p.D142Y|SLITRK2_ENST00000413937.2_Missense_Mutation_p.D142Y|SLITRK2_ENST00000447897.2_Missense_Mutation_p.D142Y			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	142						integral to membrane		p.D142Y(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					TCTCCAGGCCGACTACAATTA	0.488000													22	18					1.55795e-14	2.54687e-14	0.608945	1	0
SELP	6403	broad.mit.edu	37	1	169581604	169581604	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:169581604C>T	ENST00000263686.6	-	6	849	c.812G>A	c.(811-813)gGa>gAa	p.G271E	SELP_ENST00000367792.2_Missense_Mutation_p.G271E|SELP_ENST00000367788.2_Intron|SELP_ENST00000367786.2_Missense_Mutation_p.G271E|SELP_ENST00000458599.2_Missense_Mutation_p.G271E|SELP_ENST00000367794.2_Missense_Mutation_p.G271E|SELP_ENST00000367793.2_Intron|SELP_ENST00000367791.2_Missense_Mutation_p.G271E	NM_003005.3	NP_002996.2	P16109	LYAM3_HUMAN	selectin P (granule membrane protein 140kDa, antigen CD62)	271	Sushi 2.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding	p.G271E(1)		breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(32)|ovary(4)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GGTCATGTTTCCTCGTTCAGG	0.478000													17	42					0	0	0.520397	0	0
SPECC1	92521	broad.mit.edu	37	17	20000015	20000015	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:20000015C>T	ENST00000395529.3	+	2	103	c.51C>T	c.(49-51)caC>caT	p.H17H	SPECC1_ENST00000472876.1_Intron|SPECC1_ENST00000395527.4_Silent_p.H17H|SPECC1_ENST00000261503.5_Silent_p.H17H	NM_152904.4	NP_690868.3	Q5M775	CYTSB_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1	17						nucleus		p.H17H(1)		breast(1)|large_intestine(3)|ovary(4)	8				KIRC - Kidney renal clear cell carcinoma(2;0.166)|Kidney(2;0.196)		CAGGGGGCCACGGCCCAGACC	0.567000													8	120					0	0	0.278610	0	0
TTK	7272	broad.mit.edu	37	6	80749948	80749948	+	Silent	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:80749948C>G	ENST00000509894.1	+	20	3169	c.2340C>G	c.(2338-2340)tcC>tcG	p.S780S	TTK_ENST00000369798.2_Silent_p.S781S|TTK_ENST00000230510.3_Silent_p.S780S			P33981	TTK_HUMAN	TTK protein kinase	781	Protein kinase.				mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.S781S(1)|p.S765S(1)		endometrium(4)|kidney(2)|large_intestine(12)|lung(22)|ovary(7)|pancreas(1)|prostate(1)|stomach(3)|urinary_tract(1)	53		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		AGAGGATATCCATTCCTGAGC	0.299000													16	42					0	0	0.539581	0	0
C12orf77	196415	broad.mit.edu	37	12	25148752	25148752	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:25148752C>T	ENST00000549828.1	-	3	600	c.396G>A	c.(394-396)ggG>ggA	p.G132G	C12orf77_ENST00000549262.1_Silent_p.G77G|C12orf77_ENST00000434912.3_Silent_p.G77G	NM_001101339.1	NP_001094809.1	C9JDV5	CL097_HUMAN	chromosome 12 open reading frame 77	132								p.G132G(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)	7						TGCAGTATATCCCCAACAGGA	0.418000													5	12					0	0	0.248553	0	0
DTNB	1838	broad.mit.edu	37	2	25754371	25754371	+	Silent	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:25754371T>C	ENST00000406818.3	-	9	1221	c.972A>G	c.(970-972)ccA>ccG	p.P324P	DTNB_ENST00000545439.1_Silent_p.P120P|DTNB_ENST00000496972.2_Silent_p.P267P|DTNB_ENST00000405222.1_Silent_p.P324P|DTNB_ENST00000407186.1_Silent_p.P324P|DTNB_ENST00000404103.3_Silent_p.P324P|DTNB_ENST00000407038.3_Silent_p.P324P|DTNB_ENST00000288642.8_Silent_p.P324P|DTNB_ENST00000407661.3_Silent_p.P324P	NM_001256303.1|NM_021907.4	NP_001243232.1|NP_068707.1	O60941	DTNB_HUMAN	dystrobrevin, beta	324						cytoplasm	calcium ion binding|zinc ion binding	p.P324P(1)		endometrium(1)|large_intestine(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTGGTTTCTCTGGTTGCTCAG	0.468000													24	77					0	0	0.693898	0	0
SLFN11	91607	broad.mit.edu	37	17	33690157	33690157	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:33690157G>T	ENST00000394566.1	-	4	942	c.670C>A	c.(670-672)Caa>Aaa	p.Q224K	SLFN11_ENST00000308377.4_Missense_Mutation_p.Q224K	NM_001104587.1|NM_001104588.1|NM_001104589.1|NM_001104590.1	NP_001098057.1|NP_001098058.1|NP_001098059.1|NP_001098060.1	Q7Z7L1	SLN11_HUMAN	schlafen family member 11	224						nucleus	ATP binding	p.Q224K(1)		autonomic_ganglia(1)|breast(1)|kidney(3)|large_intestine(14)|lung(17)|ovary(1)|prostate(4)|skin(2)|stomach(5)|upper_aerodigestive_tract(2)	50		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACATATTCTTGGAAGTGTTTT	0.373000													38	101					2.87052e-16	4.88968e-16	0.812448	1	0
ANK2	287	broad.mit.edu	37	4	114277762	114277762	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:114277762C>A	ENST00000357077.4	+	38	8041	c.7988C>A	c.(7987-7989)tCc>tAc	p.S2663Y	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.S2630Y|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000506722.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2630					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding	p.S2663Y(1)		NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GTGTCTTCCTCCTCAGAAAGT	0.478000													20	20					5.35267e-07	6.78492e-07	0.557998	1	0
PIK3C2G	5288	broad.mit.edu	37	12	18719923	18719923	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:18719923C>T	ENST00000433979.1	+	28	3936	c.3820C>T	c.(3820-3822)Cac>Tac	p.H1274Y	PIK3C2G_ENST00000266497.5_Missense_Mutation_p.H1274Y|PIK3C2G_ENST00000538779.1_Missense_Mutation_p.H1315Y	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1274	PX.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity	p.H1274Y(1)		breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				AAATTCAGATCACAGAAGATT	0.284000													14	26					0	0	0.520397	0	0
CKAP5	9793	broad.mit.edu	37	11	46772905	46772905	+	Silent	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:46772905T>C	ENST00000529230.1	-	39	5359	c.5313A>G	c.(5311-5313)aaA>aaG	p.K1771K	CKAP5_ENST00000312055.5_Silent_p.K1711K|CKAP5_ENST00000354558.3_Silent_p.K1711K|CKAP5_ENST00000415402.1_Silent_p.K1771K			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	1771					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding	p.K1771K(1)		breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						CCTTGGGCCCTTTTAATTTGC	0.443000													3	116					0	0	0.115264	0	0
P2RY1	5028	broad.mit.edu	37	3	152554645	152554645	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:152554645C>T	ENST00000305097.3	+	1	1910	c.1074C>T	c.(1072-1074)acC>acT	p.T358T		NM_002563.3	NP_002554.1	P47900	P2RY1_HUMAN	purinergic receptor P2Y, G-protein coupled, 1	358					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.T358T(1)		breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			AAGACATGACCCTCAATATTT	0.438000													20	33					0	0	0.557998	0	0
HOXC13	3229	broad.mit.edu	37	12	54338921	54338921	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:54338921C>G	ENST00000243056.3	+	2	1030	c.874C>G	c.(874-876)Cgc>Ggc	p.R292G		NM_017410.2	NP_059106.2	P31276	HXC13_HUMAN	homeobox C13	292						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R292G(1)		breast(1)|large_intestine(1)|skin(1)	3						GAAGCGCCGGCGCATCTCCGC	0.582000			T	NUP98	AML								18	28					0	0	0.539581	0	0
IFI16	3428	broad.mit.edu	37	1	159021490	159021490	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:159021490G>T	ENST00000295809.7	+	10	1942	c.1687G>T	c.(1687-1689)Gaa>Taa	p.E563*	IFI16_ENST00000368131.4_Nonsense_Mutation_p.E507*|IFI16_ENST00000368132.3_Nonsense_Mutation_p.E507*|IFI16_ENST00000340979.6_Nonsense_Mutation_p.E451*|IFI16_ENST00000430894.2_Nonsense_Mutation_p.E511*|IFI16_ENST00000359709.3_Nonsense_Mutation_p.E507*|IFI16_ENST00000448393.2_Nonsense_Mutation_p.E451*			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	563	HIN-200 2.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding	p.E507*(1)		cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					ACTGAAGACTGAACCTGAAGA	0.423000													26	46					3.1745e-13	4.97644e-13	0.729181	1	0
DDX50	79009	broad.mit.edu	37	10	70694664	70694664	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:70694664A>T	ENST00000373585.3	+	10	1618	c.1511A>T	c.(1510-1512)gAa>gTa	p.E504V	DDX50_ENST00000466265.1_Intron	NM_024045.1	NP_076950.1	Q9BQ39	DDX50_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	504	Helicase C-terminal.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding	p.E504V(1)		breast(2)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	29						AGATATGTGGAACAAAAAGCA	0.373000													25	35					0	0	0.681144	0	0
SLC10A2	6555	broad.mit.edu	37	13	103718307	103718307	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:103718307A>G	ENST00000245312.3	-	1	889	c.293T>C	c.(292-294)gTa>gCa	p.V98A		NM_000452.2	NP_000443.1	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid cotransporter), member 2	98			V -> I (in dbSNP:rs55971546).		bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity	p.V98A(1)		breast(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GAGCACCACTACGGCCTGGAG	0.532000													14	59					0	0	0.500413	0	0
PKD2	5311	broad.mit.edu	37	4	88973291	88973291	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:88973291T>A	ENST00000237596.2	+	7	1763	c.1697T>A	c.(1696-1698)gTa>gAa	p.V566E	PKD2_ENST00000511337.1_3'UTR|PKD2_ENST00000508588.1_5'UTR	NM_000297.3	NP_000288.1	Q13563	PKD2_HUMAN	polycystic kidney disease 2 (autosomal dominant)	566						basal cortex|basal plasma membrane|endoplasmic reticulum|integral to membrane|lamellipodium|microtubule basal body	calcium ion binding|cytoskeletal protein binding|voltage-gated chloride channel activity|voltage-gated sodium channel activity	p.V566E(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(2)|lung(15)|skin(4)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)|Acute lymphoblastic leukemia(40;0.221)		OV - Ovarian serous cystadenocarcinoma(123;9.98e-10)|COAD - Colon adenocarcinoma(81;0.0237)		GCTGTCACAGTATTTTTTGTC	0.308000													4	54					0	0	0.184627	0	0
TRPC4	7223	broad.mit.edu	37	13	38225483	38225483	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:38225483G>A	ENST00000379705.3	-	8	2855	c.1998C>T	c.(1996-1998)ctC>ctT	p.L666L	TRPC4_ENST00000379679.1_Silent_p.L493L|TRPC4_ENST00000379673.2_Intron|TRPC4_ENST00000426868.2_3'UTR|TRPC4_ENST00000447043.1_Silent_p.L666L|TRPC4_ENST00000379681.3_Silent_p.L666L|TRPC4_ENST00000358477.2_Silent_p.L666L|TRPC4_ENST00000355779.2_Silent_p.L666L|TRPC4_ENST00000338947.5_Silent_p.L493L			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	666	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity	p.L666L(2)		NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TCAGGTACCAGAGAGACTTGG	0.423000													7	48					0	0	0.278610	0	0
CLTCL1	8218	broad.mit.edu	37	22	19230452	19230452	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr22:19230452C>A	ENST00000263200.10	-	4	599	c.527G>T	c.(526-528)cGt>cTt	p.R176L	CLTCL1_ENST00000353891.5_Missense_Mutation_p.R176L|CLTCL1_ENST00000427926.1_Missense_Mutation_p.R176L	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	176	Globular terminal domain.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity	p.R176H(1)|p.R176L(1)		breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					TCCAACCACACGGTTTTGCTA	0.383000			T	?	ALCL								4	18					0.014758	0.0154483	0.184627	1	0
ZFY	7544	broad.mit.edu	37	Y	2847526	2847526	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrY:2847526A>C	ENST00000155093.3	+	8	2219	c.1898A>C	c.(1897-1899)cAt>cCt	p.H633P	ZFY_ENST00000431102.1_Missense_Mutation_p.H442P|ZFY_ENST00000449237.1_Missense_Mutation_p.H556P|ZFY-AS1_ENST00000417305.1_RNA|ZFY_ENST00000383052.1_Missense_Mutation_p.H633P	NM_003411.3	NP_003402.2	P08048	ZFY_HUMAN	zinc finger protein, Y-linked	633					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H633P(1)		biliary_tract(1)|kidney(3)|large_intestine(1)|lung(3)	8						CAGTGTTTGCATTGCGACCAC	0.403000													25	10					0	0	0.654019	0	0
OAZ3	51686	broad.mit.edu	37	1	151742669	151742669	+	Translation_Start_Site	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:151742669C>A	ENST00000479764.1	+	0	3470				OAZ3_ENST00000400999.1_De_novo_Start_OutOfFrame|OAZ3_ENST00000315067.8_Nonsense_Mutation_p.Y122*|OAZ3_ENST00000321531.5_Nonsense_Mutation_p.Y122*|OAZ3_ENST00000453029.2_Nonsense_Mutation_p.Y135*			Q9UMX2	OAZ3_HUMAN	ornithine decarboxylase antizyme 3						cellular nitrogen compound metabolic process|regulation of cellular amino acid metabolic process|spermatogenesis	cytosol|nucleus	ornithine decarboxylase inhibitor activity	p.Y166*(1)|p.Y166Y(1)		endometrium(2)|kidney(2)|large_intestine(1)|lung(4)	9	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)		L-Ornithine(DB00129)	CCCTGGAGTACGTGGAAGAGA	0.517000													41	169					3.54909e-21	6.50666e-21	0.859065	1	0
MACF1	23499	broad.mit.edu	37	1	39893130	39893130	+	Silent	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:39893130A>G	ENST00000564288.1	+	62	17097	c.16320A>G	c.(16318-16320)caA>caG	p.Q5440Q	MACF1_ENST00000567887.1_Silent_p.Q5477Q|MACF1_ENST00000289893.4_Silent_p.Q3880Q|MACF1_ENST00000545844.1_Silent_p.Q3378Q|MACF1_ENST00000539005.1_Silent_p.Q3357Q|MACF1_ENST00000317713.7_Silent_p.Q3378Q|MACF1_ENST00000361689.2_Silent_p.Q3378Q|MACF1_ENST00000372915.3_Silent_p.Q5445Q			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5445					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding	p.Q3378Q(1)|p.Q3880Q(1)		breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGTGTAGGCAAAAACAGCTGG	0.383000													26	58					0	0	0.717897	0	0
PMCHL2	5370	broad.mit.edu	37	5	70672130	70672130	+	RNA	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:70672130G>T	ENST00000502659.2	-	0	698				PMCHL2_ENST00000450213.2_RNA																							GATGTATGCTGGGAAGAGTCT	0.328000													3	30					4.3838e-07	5.56768e-07	0.435327	1	0
IL20RB	53833	broad.mit.edu	37	3	136714381	136714381	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:136714381G>A	ENST00000329582.4	+	6	1057	c.808G>A	c.(808-810)Gtc>Atc	p.V270I	IL20RB_ENST00000309741.5_3'UTR	NM_144717.3	NP_653318.2	Q6UXL0	I20RB_HUMAN	interleukin 20 receptor beta	270						integral to membrane	receptor activity	p.V270I(2)		kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	14						CCCCGTGGTGGTCCTCCCAGA	0.512000													62	198					0	0	0.870114	0	0
MRC2	9902	broad.mit.edu	37	17	60743900	60743900	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:60743900G>T	ENST00000303375.5	+	4	1181	c.779G>T	c.(778-780)aGg>aTg	p.R260M		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	260	C-type lectin 1.				endocytosis	integral to membrane	receptor activity|sugar binding	p.R260M(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						CTGTCGTGGAGGGAGGCCTGG	0.617000													5	15					0.00198382	0.00216751	0.248553	1	0
YBX1	4904	broad.mit.edu	37	1	43166670	43166670	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:43166670A>T	ENST00000321358.7	+	7	1098	c.959A>T	c.(958-960)cAg>cTg	p.Q320L		NM_004559.3	NP_004550.2	P67809	YBOX1_HUMAN	Y box binding protein 1	320					CRD-mediated mRNA stabilization|negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|positive regulation of cell division|transcription from RNA polymerase II promoter	CRD-mediated mRNA stability complex|extracellular region|histone pre-mRNA 3'end processing complex|nucleoplasm|stress granule|U12-type spliceosomal complex	double-stranded DNA binding|protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding	p.Q320L(1)		large_intestine(2)|lung(4)|ovary(4)|prostate(4)|upper_aerodigestive_tract(2)	16	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAGGCTGAGCAGGGCGGGGCT	0.547000													15	20					0	0	0.539581	0	0
TMPRSS2	7113	broad.mit.edu	37	21	42866466	42866466	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:42866466C>A	ENST00000398585.3	-	3	226	c.166G>T	c.(166-168)Gga>Tga	p.G56*	TMPRSS2_ENST00000497881.1_Intron|TMPRSS2_ENST00000332149.5_Nonsense_Mutation_p.G19*|TMPRSS2_ENST00000458356.1_Nonsense_Mutation_p.G19*	NM_001135099.1	NP_001128571.1	O15393	TMPS2_HUMAN	transmembrane protease, serine 2	19					proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity	p.G19*(2)|p.G56*(1)	TMPRSS2/ETV1(34)|TMPRSS2/ETV5_ENST00000306376(5)|TMPRSS2/ERG(3582)|TMPRSS2/ETV4(13)	central_nervous_system(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				GGTTGGTATCCATGGTTTTCA	0.483000			T	"""ERG, ETV1, ETV4, ETV5"""	prostate								9	29					0.000274275	0.000311742	0.307466	1	0
HOXB3	3213	broad.mit.edu	37	17	46628425	46628425	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:46628425C>A	ENST00000470495.1	-	2	2014	c.567G>T	c.(565-567)aaG>aaT	p.K189N	HOXB-AS1_ENST00000502764.2_RNA|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000472863.1_Missense_Mutation_p.K116N|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Missense_Mutation_p.K57N|HOXB3_ENST00000498678.1_Missense_Mutation_p.K189N|HOXB3_ENST00000476342.1_Missense_Mutation_p.K189N|HOXB3_ENST00000311626.4_Missense_Mutation_p.K189N|HOXB-AS1_ENST00000508688.1_RNA|HOXB3_ENST00000489475.1_Missense_Mutation_p.K116N|HOXB3_ENST00000490677.1_Missense_Mutation_p.K55N|HOXB3_ENST00000485909.2_Missense_Mutation_p.K57N			P14651	HXB3_HUMAN	homeobox B3	189					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.K189N(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						TCCGCGCCCGCTTGGACGCCG	0.746000													14	56					9.16793e-09	1.24477e-08	0.520397	1	0
SNHG14	104472715	broad.mit.edu	37	15	25470204	25470204	+	RNA	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:25470204T>C	ENST00000453082.2	+	0	972					NR_003343.1																						CCAAAGGCCCTAGACCAGTGT	0.567000													6	14					0	0	0.217242	0	0
TRIO	7204	broad.mit.edu	37	5	14474198	14474198	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:14474198G>C	ENST00000344204.4	+	40	6099	c.6075G>C	c.(6073-6075)tgG>tgC	p.W2025C	TRIO_ENST00000537187.1_Missense_Mutation_p.W2025C	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2025	DH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.W2025C(1)		NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					TTTACGACTGGCACAGAGAGT	0.453000													7	61					0	0	0.307466	0	0
PLEKHM2	23207	broad.mit.edu	37	1	16057111	16057111	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:16057111T>A	ENST00000375799.3	+	15	2520	c.2293T>A	c.(2293-2295)Tgc>Agc	p.C765S	PLEKHM2_ENST00000375793.2_Missense_Mutation_p.C745S|RP11-288I21.1_ENST00000453804.1_RNA|PLEKHM2_ENST00000477849.1_3'UTR	NM_015164.2	NP_055979.2	Q8IWE5	PKHM2_HUMAN	pleckstrin homology domain containing, family M (with RUN domain) member 2	765	Interaction with sifA.				Golgi organization	cytoplasm	kinesin binding	p.C868S(1)|p.C765S(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000259)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00057)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		GCCCTGCCACTGCTCACCCCC	0.652000													3	3					0	0	0.115264	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202495	140202495	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:140202495G>A	ENST00000529859.1	+	1	1135	c.1135G>A	c.(1135-1137)Ggt>Agt	p.G379S	PCDHA5_ENST00000378126.3_Missense_Mutation_p.G379S|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.G379S|PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018908.2	NP_061731.1												p.G379S(2)		NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGTGACTCAGGTGCCAACGG	0.567000													35	70					0	0	0.769981	0	0
APP	351	broad.mit.edu	37	21	27254054	27254054	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:27254054C>G	ENST00000358918.3	-	17	2385	c.2186G>C	c.(2185-2187)cGc>cCc	p.R729P	APP_ENST00000440126.3_Missense_Mutation_p.R723P|APP_ENST00000348990.5_Missense_Mutation_p.R672P|APP_ENST00000359726.3_Missense_Mutation_p.R691P|APP_ENST00000448388.2_Missense_Mutation_p.R637P|APP_ENST00000354192.3_Missense_Mutation_p.R616P|APP_ENST00000346798.3_Missense_Mutation_p.R747P|APP_ENST00000357903.3_Missense_Mutation_p.R728P|APP_ENST00000439274.2_Missense_Mutation_p.R691P	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	747					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity	p.R747P(1)		endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				GGACAGGTGGCGCTCCTCTGG	0.478000											OREG0026148	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	62					0	0	0.592651	0	0
LAMB1	3912	broad.mit.edu	37	7	107592472	107592472	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:107592472G>A	ENST00000393561.1	-	21	3532	c.3348C>T	c.(3346-3348)ttC>ttT	p.F1116F	LAMB1_ENST00000222399.6_Silent_p.F1092F			P07942	LAMB1_HUMAN	laminin, beta 1	1092	Laminin EGF-like 12.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent	p.F1092F(1)		NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAGATGGCCCGAAGGAATGAG	0.577000													4	24					0	0	0.150653	0	0
FLG2	388698	broad.mit.edu	37	1	152327656	152327656	+	Missense_Mutation	SNP	G	G	T	rs34309186		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:152327656G>T	ENST00000388718.5	-	3	2678	c.2606C>A	c.(2605-2607)tCt>tAt	p.S869Y	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	869	Ser-rich.						calcium ion binding|structural molecule activity	p.S869Y(1)		NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAAAGCCAGATGTCTGTCC	0.498000													139	74					1.04606e-72	2.07612e-72	0.870114	1	0
RHOD	29984	broad.mit.edu	37	11	66833438	66833438	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:66833438C>T	ENST00000308831.2	+	2	289	c.204C>T	c.(202-204)caC>caT	p.H68H	RHOD_ENST00000533360.1_Silent_p.H68H|RHOD_ENST00000532559.1_Intron	NM_014578.3	NP_055393.1	O00212	RHOD_HUMAN	ras homolog family member D	68					regulation of small GTPase mediated signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity	p.H68H(1)		lung(3)	3						TGCACCTCCACATCTGGGACA	0.622000													6	6					0	0	0.217242	0	0
ABLIM2	84448	broad.mit.edu	37	4	8082493	8082493	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:8082493T>A	ENST00000296372.8	-	5	633	c.491A>T	c.(490-492)cAg>cTg	p.Q164L	ABLIM2_ENST00000407564.3_Missense_Mutation_p.Q164L|ABLIM2_ENST00000447017.2_Missense_Mutation_p.Q164L|ABLIM2_ENST00000361581.5_Missense_Mutation_p.Q164L|ABLIM2_ENST00000361737.5_Missense_Mutation_p.Q164L|ABLIM2_ENST00000545242.1_Missense_Mutation_p.Q164L|ABLIM2_ENST00000318888.4_5'UTR|ABLIM2_ENST00000546334.1_Missense_Mutation_p.Q164L|ABLIM2_ENST00000341937.5_Missense_Mutation_p.Q164L|ABLIM2_ENST00000428004.2_Missense_Mutation_p.Q164L|ABLIM2_ENST00000505872.1_Missense_Mutation_p.Q164L			Q6H8Q1	ABLM2_HUMAN	actin binding LIM protein family, member 2	164	LIM zinc-binding 3.				axon guidance|cytoskeleton organization	actin cytoskeleton|cytoplasm|intermediate filament cytoskeleton|nucleus	actin binding|zinc ion binding	p.Q164L(1)		NS(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|pancreas(3)|prostate(2)|urinary_tract(1)	25						TACCAGGGCCTGGCCATTCTT	0.552000													12	15					0	0	0.411799	0	0
CSMD3	114788	broad.mit.edu	37	8	113323375	113323375	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:113323375C>A	ENST00000297405.5	-	50	7961	c.7717G>T	c.(7717-7719)Gaa>Taa	p.E2573*	CSMD3_ENST00000455883.2_Nonsense_Mutation_p.E2469*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.E2533*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.E2503*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2573	Sushi 14.					integral to membrane|plasma membrane		p.E2573*(1)|p.E2533*(1)		breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GGTGGGGATTCTGGTGTACTA	0.398000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			6	53					0.217242	0.219269	0.217242	1	0
OR52N4	390072	broad.mit.edu	37	11	5776568	5776568	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:5776568T>A	ENST00000317254.3	+	1	646	c.598T>A	c.(598-600)Tat>Aat	p.Y200N	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Y200N(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		CAATGCCATCTATGGTCTGAT	0.502000													26	47					0	0	0.667858	0	0
APOB	338	broad.mit.edu	37	2	21251356	21251356	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:21251356G>T	ENST00000233242.1	-	13	1799	c.1672C>A	c.(1672-1674)Cga>Aga	p.R558R	APOB_ENST00000399256.4_Silent_p.R558R	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	558	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity	p.R558*(1)|p.R558R(1)		NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCAGCCAGTCGCTTATCTCCC	0.448000													40	77					2.24893e-16	3.85107e-16	0.847076	1	0
OTUD3	23252	broad.mit.edu	37	1	20216956	20216956	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:20216956G>T	ENST00000375120.3	+	2	301	c.300G>T	c.(298-300)gtG>gtT	p.V100V	OTUD3_ENST00000466697.1_3'UTR	NM_015207.1	NP_056022.1	Q5T2D3	OTUD3_HUMAN	OTU domain containing 3	100	OTU.							p.V100V(1)		breast(1)|kidney(2)|large_intestine(4)|lung(1)|skin(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000276)|Lung NSC(340;0.000338)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.12e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.000408)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AGGAGACAGTGGACTACATGA	0.443000													37	72					4.11147e-13	6.41429e-13	0.788014	1	0
APOB	338	broad.mit.edu	37	2	21233969	21233969	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:21233969G>T	ENST00000233242.1	-	26	5898	c.5771C>A	c.(5770-5772)aCt>aAt	p.T1924N		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1924					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity	p.T1924N(1)		NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGCTGCCCAGTATGTTCTCC	0.458000													52	128					1.39843e-22	2.62306e-22	0.870114	1	0
LILRA2	11027	broad.mit.edu	37	19	55086909	55086909	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:55086909C>T	ENST00000251377.3	+	6	975	c.842C>T	c.(841-843)aCc>aTc	p.T281I	LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000391737.1_Missense_Mutation_p.T269I|LILRB1_ENST00000448689.1_Intron|LILRA2_ENST00000251376.3_Missense_Mutation_p.T281I|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391738.3_Missense_Mutation_p.T281I					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2									p.T281I(1)		breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		GCCAACTTCACCCTGGGCCCT	0.632000													30	39					0	0	0.769981	0	0
YBX1	4904	broad.mit.edu	37	1	43162350	43162350	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:43162350T>C	ENST00000321358.7	+	5	531	c.392T>C	c.(391-393)gTt>gCt	p.V131A	YBX1_ENST00000467957.1_3'UTR	NM_004559.3	NP_004550.2	P67809	YBOX1_HUMAN	Y box binding protein 1	131					CRD-mediated mRNA stabilization|negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|positive regulation of cell division|transcription from RNA polymerase II promoter	CRD-mediated mRNA stability complex|extracellular region|histone pre-mRNA 3'end processing complex|nucleoplasm|stress granule|U12-type spliceosomal complex	double-stranded DNA binding|protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding	p.V131A(1)		large_intestine(2)|lung(4)|ovary(4)|prostate(4)|upper_aerodigestive_tract(2)	16	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCTGGTGGTGTTCCAGTTCAA	0.438000													22	26					0	0	0.624587	0	0
KRTAP19-6	337973	broad.mit.edu	37	21	31914037	31914037	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:31914037T>C	ENST00000334046.5	-	1	146	c.116A>G	c.(115-117)tAt>tGt	p.Y39C		NM_181612.2	NP_853643.1	Q3LI70	KR196_HUMAN	keratin associated protein 19-6	39						intermediate filament		p.Y39C(1)		breast(1)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	9						GCCATATCTATAGCCTCCATA	0.498000													52	101					0	0	0.870114	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27539347	27539347	+	RNA	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:27539347C>G	ENST00000574842.1	+	0	616				LRRC37A6P_ENST00000284414.4_RNA																							ACAGGAGGACCTGGAGGCTCA	0.597000													4	23					0	0	0.150653	0	0
IPO7	10527	broad.mit.edu	37	11	9459724	9459724	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:9459724C>T	ENST00000379719.3	+	22	2729	c.2587C>T	c.(2587-2589)Ccg>Tcg	p.P863S		NM_006391.2	NP_006382.1	O95373	IPO7_HUMAN	importin 7	863					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity	p.P863S(1)		NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		ACAGATTTTGCCGGCTTTTAT	0.398000													5	184					0	0	0.217242	0	0
NLRP3	114548	broad.mit.edu	37	1	247587436	247587436	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:247587436G>A	ENST00000366497.2	+	4	1471	c.691G>A	c.(691-693)Ggg>Agg	p.G231R	NLRP3_ENST00000348069.2_Missense_Mutation_p.G231R|NLRP3_ENST00000391828.3_Missense_Mutation_p.G231R|NLRP3_ENST00000366496.2_Missense_Mutation_p.G231R|NLRP3_ENST00000336119.3_Missense_Mutation_p.G231R|NLRP3_ENST00000391827.2_Missense_Mutation_p.G231R|NLRP3_ENST00000474792.1_3'UTR	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	231	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding	p.G231R(1)		NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GGCAGGGATTGGGAAAACAAT	0.542000													10	16					0	0	0.361761	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58024791	58024791	+	Silent	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:58024791A>T	ENST00000341156.4	-	4	1046	c.462T>A	c.(460-462)gtT>gtA	p.V154V	B4GALNT1_ENST00000449184.3_Silent_p.V154V|B4GALNT1_ENST00000418555.2_Silent_p.V99V|B4GALNT1_ENST00000552350.1_Silent_p.V154V|B4GALNT1_ENST00000550764.1_Silent_p.V154V	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	154					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity	p.V154V(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			TGAGGGGCTGAACTTCCACAC	0.642000													13	21					0	0	0.457914	0	0
TP53	7157	broad.mit.edu	37	17	7577565	7577565	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:7577565T>C	ENST00000420246.2	-	7	848	c.716A>G	c.(715-717)aAc>aGc	p.N239S	TP53_ENST00000455263.2_Missense_Mutation_p.N239S|TP53_ENST00000445888.2_Missense_Mutation_p.N239S|TP53_ENST00000359597.4_Missense_Mutation_p.N239S|TP53_ENST00000413465.2_Missense_Mutation_p.N239S|TP53_ENST00000269305.4_Missense_Mutation_p.N239S	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	239	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		N -> D (in sporadic cancers; somatic mutation).|N -> H (in a sporadic cancer; somatic mutation).|N -> I (in a sporadic cancer; somatic mutation).|N -> K (in sporadic cancers; somatic mutation).|N -> S (in sporadic cancers; somatic mutation).|N -> T (in sporadic cancers; somatic mutation).|N -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.N239S(28)|p.0?(8)|p.?(5)|p.N239T(4)|p.M237_N239delMCN(4)|p.N146S(3)|p.N239_C242delNSSC(3)|p.N239fs*25(2)|p.N239_S240delNS(2)|p.Y236_M243delYMCNSSCM(1)|p.N239fs*1(1)|p.N239_S240insN(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.N239fs*4(1)|p.C238_M246delCNSSCMGGM(1)|p.M144_N146delMCN(1)|p.C238fs*21(1)|p.N239I(1)|p.H233fs*6(1)|p.N239*(1)|p.H233_C242del10(1)|p.N239_C242>S(1)|p.N239fs*>48(1)|p.N146fs*>10(1)|p.N239_C242del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGGAACTGTTACACATGTA	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	11					0	0	0.307466	0	0
VAV2	7410	broad.mit.edu	37	9	136633629	136633629	+	Missense_Mutation	SNP	C	C	A	rs145738821		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:136633629C>A	ENST00000371851.1	-	27	2819	c.2494G>T	c.(2494-2496)Gtg>Ttg	p.V832L	VAV2_ENST00000406606.3_Missense_Mutation_p.V803L|VAV2_ENST00000371850.3_Missense_Mutation_p.V842L			P52735	VAV2_HUMAN	vav 2 guanine nucleotide exchange factor	842	SH3 2.				angiogenesis|apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	metal ion binding|Rho guanyl-nucleotide exchange factor activity	p.V842L(1)|p.V803L(1)		breast(1)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	35				OV - Ovarian serous cystadenocarcinoma(145;3.9e-07)|Epithelial(140;2.07e-06)|all cancers(34;9.39e-06)		ATCCTCACCACGTCACCCTCC	0.652000													14	38					0.000308642	0.000348363	0.479597	1	0
HIST1H3H	8357	broad.mit.edu	37	6	27778257	27778257	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:27778257G>T	ENST00000369163.2	+	1	416	c.406G>T	c.(406-408)Gct>Tct	p.A136S		NM_003536.2	NP_003527.1	P68431	H31_HUMAN	histone cluster 1, H3h	136					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding	p.A136S(1)		haematopoietic_and_lymphoid_tissue(1)|lung(4)|ovary(2)|upper_aerodigestive_tract(3)	10						CGGCGAGAGGGCTTGAGTCTC	0.552000													12	23					1.61879e-10	2.37155e-10	0.411799	1	0
ZIM3	114026	broad.mit.edu	37	19	57646434	57646434	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:57646434C>A	ENST00000269834.1	-	5	1656	c.1271G>T	c.(1270-1272)tGt>tTt	p.C424F		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	424					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.C424F(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGTTTTTCCACATTCACTACA	0.388000													19	180					2.35188e-11	3.56629e-11	0.539581	1	0
VSTM4	196740	broad.mit.edu	37	10	50255081	50255081	+	Missense_Mutation	SNP	C	C	A	rs149594660	byFrequency	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:50255081C>A	ENST00000332853.3	-	7	807	c.784G>T	c.(784-786)Gcc>Tcc	p.A262S		NM_001031746.3	NP_001026916.2	Q8IW00	CJ072_HUMAN	V-set and transmembrane domain containing 4	262						integral to membrane|plasma membrane		p.A262S(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|skin(2)	31						AACGTGGGGGCTATCGGAGCT	0.478000													37	48					2.95478e-19	5.28278e-19	0.840704	1	0
NT5DC3	51559	broad.mit.edu	37	12	104190758	104190758	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:104190758C>A	ENST00000392876.3	-	6	707	c.667G>T	c.(667-669)Gag>Tag	p.E223*	NT5DC3_ENST00000465502.1_5'UTR	NM_001031701.2	NP_001026871.1	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	223							hydrolase activity|metal ion binding	p.E148*(1)|p.E223*(1)		NS(1)|breast(1)|endometrium(1)|kidney(4)|large_intestine(3)|lung(15)|ovary(2)|skin(1)|stomach(2)	30						AGGGTCATCTCGGGCAGGGAG	0.498000													21	24					1.64113e-05	1.96512e-05	0.592651	1	0
JAK1	3716	broad.mit.edu	37	1	65323453	65323453	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:65323453G>A	ENST00000342505.4	-	10	1592	c.1344C>T	c.(1342-1344)taC>taT	p.Y448Y		NM_002227.2	NP_002218.2	P23458	JAK1_HUMAN	Janus kinase 1	448	SH2.				interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity	p.Y448Y(1)		breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(48)|kidney(3)|large_intestine(8)|liver(2)|lung(19)|ovary(1)|prostate(12)|skin(1)|soft_tissue(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	120				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TATTGATGGCGTATTCTGTAC	0.517000			Mis		ALL								6	24					0	0	0.248553	0	0
NUP205	23165	broad.mit.edu	37	7	135333220	135333220	+	Silent	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:135333220A>G	ENST00000285968.6	+	43	5981	c.5955A>G	c.(5953-5955)ttA>ttG	p.L1985L		NM_015135.2	NP_055950.1	Q92621	NU205_HUMAN	nucleoporin 205kDa	1985					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding	p.L1985L(1)		breast(4)|central_nervous_system(2)|endometrium(9)|kidney(7)|large_intestine(17)|liver(4)|lung(36)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	93						TTGAAGGATTATATTCAAAAG	0.413000													17	40					0	0	0.539581	0	0
ESF1	51575	broad.mit.edu	37	20	13755882	13755882	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:13755882C>A	ENST00000202816.1	-	4	1177	c.1070G>T	c.(1069-1071)tGg>tTg	p.W357L		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	357					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm		p.W357L(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TAATCTATCCCAGTCCATGTT	0.323000													19	66					2.54575e-18	4.46538e-18	0.592651	1	0
SPATA31E1	286234	broad.mit.edu	37	9	90501555	90501555	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:90501555G>T	ENST00000325643.5	+	4	2219	c.2153G>T	c.(2152-2154)cGg>cTg	p.R718L		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1									p.R718L(1)									GACCCAAGCCGGGATCAAGGC	0.572000													14	32					9.31168e-06	1.12959e-05	0.435327	1	0
PCDHGA12	26025	broad.mit.edu	37	5	140890662	140890662	+	Silent	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:140890662A>G	ENST00000252085.3	+	4	2863	c.2721A>G	c.(2719-2721)gcA>gcG	p.A907A	PCDHGC3_ENST00000308177.3_Silent_p.A909A|PCDHGA11_ENST00000518882.1_Silent_p.A725A|PCDHGA4_ENST00000571252.1_Silent_p.A906A|PCDHGA11_ENST00000398587.2_Silent_p.A910A|PCDHGA3_ENST00000253812.6_Silent_p.A907A|PCDHGC5_ENST00000252087.1_Silent_p.A919A|PCDHGA10_ENST00000398610.2_Silent_p.A911A|PCDHGA6_ENST00000517434.1_Silent_p.A907A|PCDHGC4_ENST00000306593.1_Silent_p.A913A|PCDHGA9_ENST00000573521.1_Silent_p.A907A|PCDHGB3_ENST00000576222.1_Silent_p.A904A|PCDHGB4_ENST00000519479.1_Silent_p.A898A|PCDHGA5_ENST00000518069.1_Silent_p.A906A|PCDHGB2_ENST00000522605.1_Silent_p.A906A|PCDHGA1_ENST00000517417.1_Silent_p.A906A|PCDHGA7_ENST00000518325.1_Silent_p.A907A|PCDHGB1_ENST00000523390.1_Silent_p.A902A|PCDHGB7_ENST00000398594.2_Silent_p.A904A|PCDHGB6_ENST00000520790.1_Silent_p.A905A|PCDHGA2_ENST00000394576.2_Silent_p.A907A|PCDHGA8_ENST00000398604.2_Silent_p.A907A	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1												p.A907A(9)|p.A906A(7)|p.A904A(3)|p.A919A(2)|p.A909A(2)|p.A902A(2)|p.A905A(1)|p.A910A(1)|p.A911A(1)|p.A898A(1)|p.A913A(1)		breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGACCAACGCAGCTGGCAAGC	0.602000													15	65					0	0	0.520397	0	0
UBN2	254048	broad.mit.edu	37	7	138946381	138946381	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:138946381C>A	ENST00000288561.8	+	6	1289	c.1040C>A	c.(1039-1041)aCc>aAc	p.T347N	UBN2_ENST00000473989.2_Missense_Mutation_p.T430N	NM_173569.3	NP_775840.3	Q6ZU65	UBN2_HUMAN	ubinuclein 2	430								p.T347N(1)		NS(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	42						GAAAATGGAACCACCACCCAG	0.483000													15	42					1.3612e-06	1.70216e-06	0.479597	1	0
SUV39H2	79723	broad.mit.edu	37	10	14939506	14939506	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:14939506A>C	ENST00000313519.5	+	2	890	c.659A>C	c.(658-660)tAt>tCt	p.Y220S	SUV39H2_ENST00000354919.6_Missense_Mutation_p.Y280S|DCLRE1C_ENST00000378289.4_3'UTR|SUV39H2_ENST00000378325.3_Intron	NM_001193425.1|NM_024670.3	NP_001180354.1|NP_078946.1	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2 (Drosophila)	280	Pre-SET.				cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding	p.Y280S(1)|p.Y220S(1)		breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)	19						GTCATGGAATATGTTGGAGAG	0.383000													3	58					0	0	0.115264	0	0
KIF1A	547	broad.mit.edu	37	2	241706739	241706739	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:241706739G>T	ENST00000498729.2	-	18	1767	c.1521C>A	c.(1519-1521)aaC>aaA	p.N507K	KIF1A_ENST00000320389.7_Missense_Mutation_p.N498K	NM_001244008.1	NP_001230937.1	Q12756	KIF1A_HUMAN	kinesin family member 1A	498					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity	p.N498K(1)		NS(1)|central_nervous_system(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(25)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	66		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		GCGGGTCCTCGTTCAGGTTGA	0.617000													7	17					0.0293803	0.0303628	0.248553	1	0
RYR1	6261	broad.mit.edu	37	19	38980787	38980787	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:38980787G>T	ENST00000355481.4	+	36	6017	c.5886G>T	c.(5884-5886)gcG>gcT	p.A1962A	RYR1_ENST00000359596.3_Silent_p.A1962A|RYR1_ENST00000360985.3_Silent_p.A1962A	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1962	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.A1962A(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CAGCCTTTGCGGAGCGCTATG	0.592000													25	39					7.88262e-20	1.41321e-19	0.654019	1	0
SMC5	23137	broad.mit.edu	37	9	72879306	72879306	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:72879306G>T	ENST00000361138.5	+	2	330	c.272G>T	c.(271-273)tGt>tTt	p.C91F		NM_015110.3	NP_055925.2	Q8IY18	SMC5_HUMAN	structural maintenance of chromosomes 5	91					DNA recombination|DNA repair	chromosome|nucleus	ATP binding	p.C91F(1)		breast(1)|central_nervous_system(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(4)	35						AGCATTGTGTGTGCCATTTGC	0.373000													13	63					1.99824e-07	2.59371e-07	0.520397	1	0
FHIT	2272	broad.mit.edu	37	3	59908137	59908137	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:59908137C>G	ENST00000468189.1	-	8	653	c.283G>C	c.(283-285)Gtt>Ctt	p.V95L	FHIT_ENST00000476844.1_Missense_Mutation_p.V95L|FHIT_ENST00000341848.4_Missense_Mutation_p.V95L|FHIT_ENST00000492590.1_Missense_Mutation_p.V95L|FHIT_ENST00000466788.1_5'UTR			P49789	FHIT_HUMAN	fragile histidine triad	95	Binding to substrate; phosphate linker.|HIT.				nucleotide metabolic process		bis(5'-adenosyl)-triphosphatase activity|protein binding	p.V95L(2)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(5)|prostate(1)|stomach(1)	12		all_cancers(2;2.37e-314)|all_epithelial(2;5.17e-286)|Colorectal(2;1.24e-68)|all_lung(2;1.31e-45)|Lung NSC(2;1.79e-44)|all_hematologic(2;1.59e-23)|Renal(2;1.03e-13)|Breast(2;1.06e-10)|Esophageal squamous(2;6.31e-09)|Melanoma(2;1.83e-07)|Acute lymphoblastic leukemia(2;5.46e-05)|all_neural(2;0.00118)|Medulloblastoma(2;0.00263)|Hepatocellular(2;0.0245)|Ovarian(2;0.0408)		UCEC - Uterine corpus endometrioid carcinoma (45;0.0887)|Epithelial(1;9.28e-70)|all cancers(1;3.07e-60)|Colorectal(1;2.33e-53)|STAD - Stomach adenocarcinoma(1;7.22e-48)|COAD - Colon adenocarcinoma(3;1.05e-44)|READ - Rectum adenocarcinoma(3;2.41e-08)|KIRC - Kidney renal clear cell carcinoma(10;0.000109)|Kidney(10;0.000125)|Lung(1;0.000161)|LUSC - Lung squamous cell carcinoma(1;0.000742)|OV - Ovarian serous cystadenocarcinoma(275;0.00372)|BRCA - Breast invasive adenocarcinoma(55;0.00448)		TGGACGTGAACGTGCTGAAAA	0.418000			T	HMGA2	pleomorphic salivary gland adenoma				Renal Cell Cancer associated with constitutional translocation of chromosome 3				9	30					0	0	0.307466	0	0
LRRC8A	56262	broad.mit.edu	37	9	131670679	131670679	+	Silent	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:131670679G>C	ENST00000259324.5	+	3	1759	c.1236G>C	c.(1234-1236)acG>acC	p.T412T	LRRC8A_ENST00000372600.4_Silent_p.T412T|LRRC8A_ENST00000372599.3_Silent_p.T412T	NM_001127244.1	NP_001120716.1	Q8IWT6	LRC8A_HUMAN	leucine rich repeat containing 8 family, member A	412					pre-B cell differentiation	integral to membrane		p.T412T(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(3)	28						ACGAGTGGACGCTGGACAAGC	0.587000													6	38					0	0	0.248553	0	0
TUBB4A	10382	broad.mit.edu	37	19	6495933	6495933	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:6495933C>G	ENST00000264071.2	-	4	948	c.577G>C	c.(577-579)Gtg>Ctg	p.V193L	TUBB4A_ENST00000540257.1_Missense_Mutation_p.V193L			P04350	TBB4_HUMAN	tubulin, beta 4A class IVa	193					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity	p.V193L(1)									GTATTCTCCACCAGCTGGTGC	0.592000													29	57					0	0	0.717897	0	0
OR4N2	390429	broad.mit.edu	37	14	20295622	20295622	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:20295622C>A	ENST00000568211.1	+	1	15	c.15C>A	c.(13-15)aaC>aaA	p.N5K	OR4N2_ENST00000315947.1_Missense_Mutation_p.N5K			Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.N5K(1)		breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAAGCGAGAACAGAACAGTGA	0.373000													36	116					2.51541e-25	4.80147e-25	0.804634	1	0
LPHN3	23284	broad.mit.edu	37	4	62599218	62599218	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:62599218A>C	ENST00000512091.1	+	7	1888	c.1141A>C	c.(1141-1143)Aac>Cac	p.N381H	LPHN3_ENST00000508946.1_Missense_Mutation_p.N381H|LPHN3_ENST00000514996.1_Missense_Mutation_p.N381H|LPHN3_ENST00000509896.1_Missense_Mutation_p.N449H|LPHN3_ENST00000514157.1_Missense_Mutation_p.N381H|LPHN3_ENST00000506720.1_Missense_Mutation_p.N449H|LPHN3_ENST00000506700.1_Missense_Mutation_p.N381H|LPHN3_ENST00000506746.1_Missense_Mutation_p.N449H|LPHN3_ENST00000514591.1_Missense_Mutation_p.N381H|LPHN3_ENST00000507625.1_Missense_Mutation_p.N449H|LPHN3_ENST00000511324.1_Missense_Mutation_p.N449H|LPHN3_ENST00000507164.1_Missense_Mutation_p.N449H|LPHN3_ENST00000545650.1_Missense_Mutation_p.N381H|LPHN3_ENST00000508693.1_Missense_Mutation_p.N449H|LPHN3_ENST00000504896.1_Missense_Mutation_p.N381H			Q9HAR2	LPHN3_HUMAN	latrophilin 3	381	Olfactomedin-like.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding	p.N381H(3)		breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TGTATGGAATAACTATCACGT	0.393000													5	22					0	0	0.217242	0	0
SMEK2	57223	broad.mit.edu	37	2	55808792	55808792	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:55808792C>T	ENST00000272313.5	-	8	1603	c.1276G>A	c.(1276-1278)Gat>Aat	p.D426N	SMEK2_ENST00000345102.5_Missense_Mutation_p.D426N|SMEK2_ENST00000407823.3_Missense_Mutation_p.D426N	NM_020463.2	NP_065196.1	Q5MIZ7	P4R3B_HUMAN	SMEK homolog 2, suppressor of mek1 (Dictyostelium)	426						microtubule organizing center|nucleus	protein binding	p.D426N(2)		kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	16			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGATCAGTATCACAGATCATT	0.363000													4	69					0	0	0.150653	0	0
ITGA1	3672	broad.mit.edu	37	5	52214578	52214578	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:52214578G>T	ENST00000282588.6	+	16	2463	c.2005G>T	c.(2005-2007)Gta>Tta	p.V669L		NM_181501.1	NP_852478.1	P56199	ITA1_HUMAN	integrin, alpha 1	669					axon guidance|cell-matrix adhesion|integrin-mediated signaling pathway|muscle contraction	integrin complex	collagen binding|receptor activity	p.V669L(1)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(19)|ovary(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(810;5.05e-05)|Breast(144;0.0851)				AGATGTGGCCGTAGTTAAAGT	0.373000													17	15					1.33834e-09	1.89646e-09	0.557998	1	0
ARHGAP36	158763	broad.mit.edu	37	X	130215841	130215841	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:130215841T>A	ENST00000276211.5	+	2	547	c.202T>A	c.(202-204)Tac>Aac	p.Y68N	ARHGAP36_ENST00000370922.1_Missense_Mutation_p.Y56N	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	68					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity	p.Y68N(1)		breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						AGAGACTGCTTACCACGAACT	0.572000													48	27					0	0	0.870114	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770398	31770398	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:31770398C>A	ENST00000240587.4	-	2	628	c.301G>T	c.(301-303)Gag>Tag	p.E101*		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	101					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E101*(1)		breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					ACCGTGACCTCCTTGGTCTCC	0.532000													144	40					2.909e-70	5.75592e-70	0.870114	1	0
RNF123	63891	broad.mit.edu	37	3	49749945	49749945	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:49749945G>A	ENST00000327697.6	+	27	2674	c.2530G>A	c.(2530-2532)Gtc>Atc	p.V844I	RNF123_ENST00000432042.1_Missense_Mutation_p.V698I	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	844						cytoplasm	ligase activity|protein binding|zinc ion binding	p.V844I(1)		NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GCTGCTGCGCGTCTGCCTGCG	0.612000													13	28					0	0	0.435327	0	0
GALNT3	2591	broad.mit.edu	37	2	166605329	166605329	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:166605329C>G	ENST00000392701.3	-	11	2639	c.1864G>C	c.(1864-1866)Gat>Cat	p.D622H	GALNT3_ENST00000409882.1_Missense_Mutation_p.D360H	NM_004482.3	NP_004473.2	Q14435	GALT3_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)	622	Ricin B-type lectin.				protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	Golgi cisterna membrane|integral to membrane|membrane fraction|nucleus|perinuclear region of cytoplasm	calcium ion binding|manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding	p.D622H(1)		NS(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|skin(1)	20						TGGAGTGGATCTGATGGGTTG	0.333000													3	23					0	0	0.115264	0	0
GRIN3A	116443	broad.mit.edu	37	9	104449121	104449121	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:104449121C>A	ENST00000361820.3	-	2	1661	c.1061G>T	c.(1060-1062)tGg>tTg	p.W354L		NM_133445.2	NP_597702.2	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A	354					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding	p.W354L(1)		breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(44)|ovary(4)|pancreas(1)|skin(7)|upper_aerodigestive_tract(1)	80		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TCCCAGCACCCAACGAAGTTC	0.517000													7	23					0.00829132	0.00882142	0.361761	1	0
GART	2618	broad.mit.edu	37	21	34889378	34889378	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:34889378G>A	ENST00000381831.3	-	16	2288	c.2025C>T	c.(2023-2025)gtC>gtT	p.V675V	GART_ENST00000381815.4_Silent_p.V675V|GART_ENST00000381839.3_Silent_p.V675V|GART_ENST00000543717.1_Silent_p.V227V	NM_001136005.1	NP_001129477.1	P22102	PUR2_HUMAN	phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase	675	AIRS.				'de novo' IMP biosynthetic process|purine base biosynthetic process	cytosol	ATP binding|metal ion binding|methyltransferase activity|phosphoribosylamine-glycine ligase activity|phosphoribosylformylglycinamidine cyclo-ligase activity|phosphoribosylglycinamide formyltransferase activity|protein binding	p.V675V(1)		NS(2)|breast(1)|endometrium(3)|large_intestine(3)|lung(13)|ovary(3)|prostate(5)|urinary_tract(1)	31					Pemetrexed(DB00642)	CAAAGGCTTTGACATGTCCTG	0.448000													29	79					0	0	0.740014	0	0
DSCAML1	57453	broad.mit.edu	37	11	117392117	117392117	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:117392117G>A	ENST00000321322.6	-	6	1122	c.1121C>T	c.(1120-1122)cCc>cTc	p.P374L	DSCAML1_ENST00000527706.1_Missense_Mutation_p.P104L	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	314	Ig-like C2-type 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity	p.P374L(1)		breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACATGAAGGGGATCTGGGCC	0.592000													9	10					0	0	0.387290	0	0
CDC40	51362	broad.mit.edu	37	6	110551182	110551182	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:110551182G>T	ENST00000368932.1	+	16	1689	c.1588G>T	c.(1588-1590)Gga>Tga	p.G530*	CDC40_ENST00000368933.1_Intron|CDC40_ENST00000445340.2_Intron|CDC40_ENST00000307731.1_Nonsense_Mutation_p.G530*|CDC40_ENST00000368930.1_Intron			O60508	PRP17_HUMAN	cell division cycle 40	530					mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm		p.G530*(1)		breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)	18		all_cancers(87;6.23e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		Epithelial(106;0.0221)|all cancers(137;0.0314)|OV - Ovarian serous cystadenocarcinoma(136;0.034)		AGATGGAAATGGAAAATTAAA	0.353000													12	43					0.000219431	0.000252055	0.457914	1	0
RP11-337C18.8	0	broad.mit.edu	37	1	146650133	146650133	+	RNA	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:146650133A>C	ENST00000607149.1	+	0	350																											AATTTAAGAAATTCATTAGTG	0.448000													34	53					0	0	0.769981	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	4967037	4967037	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrY:4967037C>A	ENST00000333703.4	+	5	1898	c.1385C>A	c.(1384-1386)gCt>gAt	p.A462D	PCDH11Y_ENST00000215473.6_Missense_Mutation_p.A473D|PCDH11Y_ENST00000362095.5_Missense_Mutation_p.A473D	NM_001278619.1|NM_032971.2	NP_001265548.1|NP_116753.1	Q9BZA8	PC11Y_HUMAN	protocadherin 11 Y-linked	473	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A473D(2)|p.A462D(1)		autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						GCTGCAGATGCTGGCAAACCT	0.403000													21	14					9.04072e-19	1.59875e-18	0.779181	1	0
ADAMTSL4	54507	broad.mit.edu	37	1	150529802	150529802	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:150529802T>C	ENST00000271643.4	+	12	2274	c.2038T>C	c.(2038-2040)Tgc>Cgc	p.C680R	ADAMTSL4_ENST00000369041.5_Missense_Mutation_p.C680R|ADAMTSL4_ENST00000369038.2_Missense_Mutation_p.C680R|RP11-54A4.2_ENST00000442435.2_RNA|ADAMTSL4_ENST00000369039.5_Missense_Mutation_p.C703R	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	680					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding	p.C680R(1)		breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTCAGCGTCCTGCGGGAAAGG	0.657000													4	9					0	0	0.184627	0	0
ZNF568	374900	broad.mit.edu	37	19	37440956	37440956	+	Missense_Mutation	SNP	A	A	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:37440956A>C	ENST00000415168.1	+	5	1085	c.709A>C	c.(709-711)Act>Cct	p.T237P	ZNF568_ENST00000333987.7_Missense_Mutation_p.T301P|ZNF568_ENST00000427117.1_Intron|ZNF568_ENST00000455427.2_Intron	NM_001204837.1	NP_001191766.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.T301P(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAGAATTCATACTGGGGAGAA	0.378000													31	42					0	0	0.750413	0	0
DNAH11	8701	broad.mit.edu	37	7	21827064	21827064	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:21827064A>G	ENST00000328843.6	+	61	9839	c.9808A>G	c.(9808-9810)Att>Gtt	p.I3270V	DNAH11_ENST00000409508.3_Missense_Mutation_p.I3263V			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3270	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity	p.I3270V(1)		NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CAAAGAGCACATTCCAGAGAA	0.373000									Kartagener syndrome				14	43					0	0	0.457914	0	0
HAP1	9001	broad.mit.edu	37	17	39888998	39888998	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:39888998G>T	ENST00000393939.2	-	2	531	c.522C>A	c.(520-522)gtC>gtA	p.V174V	JUP_ENST00000540235.1_Intron|HAP1_ENST00000310778.5_Silent_p.V174V|HAP1_ENST00000347901.4_Silent_p.V174V|HAP1_ENST00000341193.5_Silent_p.V174V			P54257	HAP1_HUMAN	huntingtin-associated protein 1	174	HAP1 N-terminal.				brain development|protein localization|synaptic transmission	actin cytoskeleton	protein binding	p.V174V(1)		breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(4)|skin(1)	21		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			ACATCACTTTGACGTCTTCCT	0.522000													19	58					5.03518e-11	7.51226e-11	0.557998	1	0
CXXC11	285093	broad.mit.edu	37	2	242814381	242814381	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:242814381C>A	ENST00000343216.3	+	2	702	c.674C>A	c.(673-675)cCt>cAt	p.P225H		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	225						integral to membrane		p.P225Q(1)									CCTGCCCCCCCTGCGGGGGCC	0.667000													14	25					0.000308642	0.000348363	0.479597	1	0
AGBL2	79841	broad.mit.edu	37	11	47712103	47712103	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:47712103C>T	ENST00000525123.1	-	10	1441	c.1156G>A	c.(1156-1158)Gac>Aac	p.D386N	AGBL2_ENST00000298861.4_Missense_Mutation_p.D386N|AGBL2_ENST00000357610.3_Missense_Mutation_p.D386N|AGBL2_ENST00000528244.1_Missense_Mutation_p.D348N|AGBL2_ENST00000529712.1_5'UTR	NM_024783.3	NP_079059.2	Q5U5Z8	CBPC2_HUMAN	ATP/GTP binding protein-like 2	386					proteolysis	cytosol	metallocarboxypeptidase activity|zinc ion binding	p.D386N(1)		NS(1)|endometrium(5)|kidney(1)|large_intestine(8)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)	34						GTGTCCTGGTCATATGGAAAC	0.458000													25	47					0	0	0.667858	0	0
TMCO4	255104	broad.mit.edu	37	1	20082238	20082238	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:20082238C>T	ENST00000294543.6	-	7	645	c.404G>A	c.(403-405)aGa>aAa	p.R135K	TMCO4_ENST00000375122.2_Missense_Mutation_p.R135K|TMCO4_ENST00000375127.1_Missense_Mutation_p.R135K	NM_181719.4	NP_859070.3	Q5TGY1	TMCO4_HUMAN	transmembrane and coiled-coil domains 4	135						integral to membrane		p.R135K(1)		biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|lung(11)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;0.000147)|Renal(390;0.000469)|all_lung(284;0.00519)|Breast(348;0.00526)|Lung NSC(340;0.00544)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00708)|COAD - Colon adenocarcinoma(152;2.28e-05)|BRCA - Breast invasive adenocarcinoma(304;5.8e-05)|Kidney(64;0.000367)|GBM - Glioblastoma multiforme(114;0.000377)|KIRC - Kidney renal clear cell carcinoma(64;0.00459)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0862)|Lung(427;0.223)		AACGAGGACTCTGGCCCGGGC	0.478000													22	59					0	0	0.624587	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955987	18955987	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:18955987G>A	ENST00000302797.3	-	1	569	c.345C>T	c.(343-345)gcC>gcT	p.A115A	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	115					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.A115A(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CGGTGCTCACGGCACTCAGAA	0.567000													16	88					0	0	0.479597	0	0
IVL	3713	broad.mit.edu	37	1	152882759	152882759	+	Missense_Mutation	SNP	C	C	A	rs12045716		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:152882759C>A	ENST00000368764.3	+	2	550	c.486C>A	c.(484-486)caC>caA	p.H162Q	IVL_ENST00000392667.2_Missense_Mutation_p.H16Q			P07476	INVO_HUMAN	involucrin	162	39 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]- [QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD].				isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity	p.H162Q(1)		breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			aggaggggcacctgaagcacc	0.592000													8	19					0.335167	0.33777	0.335167	1	0
RYR1	6261	broad.mit.edu	37	19	38959634	38959634	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:38959634C>A	ENST00000355481.4	+	26	3541	c.3410C>A	c.(3409-3411)cCa>cAa	p.P1137Q	RYR1_ENST00000359596.3_Missense_Mutation_p.P1137Q|RYR1_ENST00000360985.3_Missense_Mutation_p.P1137Q	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	1137	6 X approximate repeats.|B30.2/SPRY 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.P1137Q(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GGCAGTGAACCATTTGGGCGC	0.567000													20	34					1.00905e-13	1.61298e-13	0.575678	1	0
PAM	5066	broad.mit.edu	37	5	102285239	102285239	+	Splice_Site	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:102285239A>G	ENST00000438793.3	+	9	1113		c.e9-1		PAM_ENST00000304400.7_Splice_Site|PAM_ENST00000379787.4_Splice_Site|PAM_ENST00000274392.9_Splice_Site|PAM_ENST00000346918.2_Splice_Site|PAM_ENST00000455264.2_Splice_Site|PAM_ENST00000348126.2_Splice_Site	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase						peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding	p.?(2)		endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	CATTTCCCACAGTGGTGAATT	0.338000													18	31					0	0	0.575678	0	0
TBX4	9496	broad.mit.edu	37	17	59560841	59560841	+	Silent	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:59560841A>T	ENST00000393853.4	+	9	1768	c.1605A>T	c.(1603-1605)tcA>tcT	p.S535S	TBX4_ENST00000240335.1_Silent_p.S534S			P57082	TBX4_HUMAN	T-box 4	534					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.S534S(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						AGTACCATTCAGGAATGGGGA	0.527000													18	27					0	0	0.557998	0	0
IGSF11	152404	broad.mit.edu	37	3	118624546	118624546	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:118624546G>T	ENST00000354673.2	-	7	977	c.597C>A	c.(595-597)gtC>gtA	p.V199V	IGSF11_ENST00000441144.2_Silent_p.V199V|IGSF11_ENST00000489689.1_Silent_p.V200V|IGSF11_ENST00000393775.2_Silent_p.V200V|IGSF11_ENST00000491903.1_Silent_p.V200V|IGSF11_ENST00000425327.2_Silent_p.V199V	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	200	Ig-like C2-type.				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity	p.V199V(1)|p.V200V(1)		autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						TCCGGATGGTGACTGTTCCCT	0.463000													14	40					7.93312e-07	9.99727e-07	0.457914	1	0
ADRA2C	152	broad.mit.edu	37	4	3769638	3769638	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:3769638C>A	ENST00000330055.5	+	1	1514	c.1305C>A	c.(1303-1305)gtC>gtA	p.V435V	ADRA2C_ENST00000509482.1_Intron	NM_000683.3	NP_000674.2	P18825	ADA2C_HUMAN	adrenoceptor alpha 2C	435					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|energy reserve metabolic process|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation|regulation of insulin secretion	endosome|integral to plasma membrane	alpha-2A adrenergic receptor binding|alpha2-adrenergic receptor activity|epinephrine binding|protein heterodimerization activity|protein homodimerization activity	p.V435V(1)		endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	8				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)	Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	TCAACCCGGTCATCTACACGG	0.602000													3	22					0.00909568	0.00961416	0.150653	1	0
LRRC1	55227	broad.mit.edu	37	6	53706983	53706983	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:53706983G>T	ENST00000370888.1	+	2	512	c.235G>T	c.(235-237)Gca>Tca	p.A79S	LRRC1_ENST00000370882.1_Missense_Mutation_p.A79S	NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	79						cytoplasm|membrane		p.A79S(1)		cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		TCCAGAAATAGCAAACTTCAT	0.403000													15	47					0.000566183	0.000636833	0.520397	1	0
KRTAP9-3	83900	broad.mit.edu	37	17	39389027	39389027	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:39389027C>A	ENST00000411528.2	+	1	313	c.274C>A	c.(274-276)Cag>Aag	p.Q92K		NM_031962.2	NP_114168.1	Q9BYQ3	KRA93_HUMAN	keratin associated protein 9-3	92	16 X 5 AA repeats of C-C-[RQVSHE]-[SPTN]- [TASPI].					keratin filament	protein binding	p.Q92K(1)		breast(1)|endometrium(3)|lung(2)|ovary(1)|prostate(1)	8		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CAGCTGTGGTCAGAGCAGCTC	0.597000													26	58					4.59853e-10	6.60275e-10	0.693898	1	0
OR5T3	390154	broad.mit.edu	37	11	56020158	56020158	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:56020158G>A	ENST00000303059.3	+	1	483	c.483G>A	c.(481-483)ctG>ctA	p.L161L		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L161L(1)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					ACCCTCTCCTGTATTCAGTGA	0.413000													22	127					0	0	0.624587	0	0
NLRC3	197358	broad.mit.edu	37	16	3600416	3600416	+	RNA	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:3600416C>T	ENST00000301749.7	-	0	2838				NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000419350.2_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding	p.L857L(1)		breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGACTCACTCCAGGCTCTCCA	0.572000													10	21					0	0	0.361761	0	0
BRD2	6046	broad.mit.edu	37	6	32943245	32943245	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:32943245G>A	ENST00000395289.2	+	4	2019	c.418G>A	c.(418-420)Gag>Aag	p.E140K	BRD2_ENST00000374825.4_Missense_Mutation_p.E140K|BRD2_ENST00000449085.2_Missense_Mutation_p.E93K|BRD2_ENST00000374831.4_Missense_Mutation_p.E140K|BRD2_ENST00000443797.2_Missense_Mutation_p.E20K|BRD2_ENST00000395287.1_Missense_Mutation_p.E140K			P25440	BRD2_HUMAN	bromodomain containing 2	140	Bromo 1.				spermatogenesis	nucleus	protein serine/threonine kinase activity	p.E140K(1)		central_nervous_system(3)|stomach(2)	5						GGCTGCTTCAGAGTGTATGCA	0.333000													11	46					0	0	0.387290	0	0
PGBD2	267002	broad.mit.edu	37	1	249211251	249211251	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:249211251C>T	ENST00000539153.1	+	4	714	c.459C>T	c.(457-459)ttC>ttT	p.F153F	PGBD2_ENST00000355360.4_Intron|PGBD2_ENST00000462488.1_Intron|PGBD2_ENST00000329291.5_Silent_p.F156F			Q6P3X8	PGBD2_HUMAN	piggyBac transposable element derived 2	156								p.F156F(1)		NS(1)|endometrium(3)|lung(6)|ovary(1)|skin(3)	14	all_cancers(71;3.33e-06)|all_epithelial(71;2.41e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.0458)|Lung NSC(105;0.0494)|Melanoma(84;0.199)	all_cancers(173;0.012)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CAATTAATTTCATTGTTAATG	0.383000													8	98					0	0	0.335167	0	0
THSD7A	221981	broad.mit.edu	37	7	11675994	11675994	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:11675994G>T	ENST00000423059.3	-	2	1036	c.785C>A	c.(784-786)aCc>aAc	p.T262N		NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	262						integral to membrane		p.T262N(1)		NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CATTGAGCAGGTGCTCCAGGG	0.572000										HNSCC(18;0.044)			15	58					4.75885e-15	7.89896e-15	0.520397	1	0
DQX1	165545	broad.mit.edu	37	2	74751135	74751135	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:74751135C>T	ENST00000404568.3	-	4	950	c.731G>A	c.(730-732)cGg>cAg	p.R244Q	DQX1_ENST00000393951.2_Missense_Mutation_p.R244Q|DQX1_ENST00000495597.1_5'UTR	NM_133637.2	NP_598376.2	Q8TE96	DQX1_HUMAN	DEAQ box RNA-dependent ATPase 1	244						nucleus	ATP binding|helicase activity|nucleic acid binding	p.R126Q(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	18						AGCTTCCACCCGATCAGGTGG	0.532000													4	50					0	0	0.150653	0	0
FAT2	2196	broad.mit.edu	37	5	150887062	150887062	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:150887062G>A	ENST00000261800.5	-	22	12182	c.12170C>T	c.(12169-12171)gCg>gTg	p.A4057V		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	4057					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding	p.A4057V(1)		NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GATAATGAACGCCACGGCCAC	0.582000													7	53					0	0	0.278610	0	0
KIAA0556	23247	broad.mit.edu	37	16	27761018	27761018	+	Missense_Mutation	SNP	C	C	T	rs150681595		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:27761018C>T	ENST00000261588.4	+	16	2756	c.2737C>T	c.(2737-2739)Cgc>Tgc	p.R913C		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	913								p.R913C(2)		breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						CCACCGGGGACGCATCTCCAA	0.642000													26	44					0	0	0.729181	0	0
STK24	8428	broad.mit.edu	37	13	99127110	99127110	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:99127110G>A	ENST00000397517.2	-	5	638	c.562C>T	c.(562-564)Ccc>Tcc	p.P188S	STK24_ENST00000376547.3_Missense_Mutation_p.P200S|STK24_ENST00000539966.1_Missense_Mutation_p.P169S	NM_001032296.2	NP_001027467.2	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24	200	Protein kinase.				cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity	p.P200S(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	17	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			ATGACCTCGGGTGCCATCCAG	0.622000													22	64					0	0	0.654019	0	0
TPSD1	23430	broad.mit.edu	37	16	1306527	1306527	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:1306527G>T	ENST00000211076.3	+	2	241	c.93G>T	c.(91-93)caG>caT	p.Q31H	TPSD1_ENST00000397534.2_Missense_Mutation_p.Q24H	NM_012217.2	NP_036349.1	Q9BZJ3	TRYD_HUMAN	tryptase delta 1	31					proteolysis	extracellular region	serine-type endopeptidase activity	p.Q31H(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	20		Hepatocellular(780;0.00369)				CCCCAGGCCAGGCCCTGCAGC	0.701000													17	52					3.41278e-10	4.94396e-10	0.520397	1	0
GPNMB	10457	broad.mit.edu	37	7	23306169	23306169	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:23306169G>A	ENST00000258733.4	+	7	1347	c.1052G>A	c.(1051-1053)aGg>aAg	p.R351K	GPNMB_ENST00000453162.2_Missense_Mutation_p.R305K|GPNMB_ENST00000539136.1_Missense_Mutation_p.R252K|GPNMB_ENST00000381990.2_Missense_Mutation_p.R363K			Q14956	GPNMB_HUMAN	glycoprotein (transmembrane) nmb	363					negative regulation of cell proliferation	melanosome		p.R363K(1)		breast(5)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(2)|lung(17)|ovary(3)|stomach(2)	41			GBM - Glioblastoma multiforme(13;0.154)			GAGCTGAGTAGGATTCCTGAT	0.428000													13	54					0	0	0.435327	0	0
AXDND1	126859	broad.mit.edu	37	1	179347807	179347807	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:179347807A>T	ENST00000367618.3	+	5	797	c.410A>T	c.(409-411)aAa>aTa	p.K137I	AXDND1_ENST00000457238.2_Missense_Mutation_p.K137I|AXDND1_ENST00000461179.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	137								p.K137I(1)		NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						ACATATGCCAAAGGACAGACT	0.368000													30	52					0	0	0.706142	0	0
ISOC2	79763	broad.mit.edu	37	19	55967071	55967071	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:55967071C>A	ENST00000085068.3	-	3	416	c.280G>T	c.(280-282)Gag>Tag	p.E94*	ISOC2_ENST00000425675.2_Nonsense_Mutation_p.E94*|ISOC2_ENST00000438389.2_Intron	NM_001136201.1|NM_024710.2	NP_001129673.1|NP_078986.1	Q96AB3	ISOC2_HUMAN	isochorismatase domain containing 2	94					protein destabilization	mitochondrion|nucleus	catalytic activity|protein binding	p.E94*(1)		endometrium(1)|lung(4)|ovary(1)|stomach(1)	7	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0535)		CTGTCCAGCTCCTGCTGCAGG	0.672000													8	8					0.000157383	0.000181747	0.278610	1	0
GNAZ	2781	broad.mit.edu	37	22	23437951	23437951	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr22:23437951G>T	ENST00000248996.4	+	2	735	c.69G>T	c.(67-69)ctG>ctT	p.L23L	RTDR1_ENST00000216036.4_Intron	NM_002073.2	NP_002064.1	P19086	GNAZ_HUMAN	guanine nucleotide binding protein (G protein), alpha z polypeptide	23						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity	p.L23L(1)		endometrium(3)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(5)|urinary_tract(1)	19	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		ACCGCCACCTGCGCTCAGAGA	0.602000													27	20					1.5548e-18	2.73459e-18	0.693898	1	0
MYOD1	4654	broad.mit.edu	37	11	17742882	17742882	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:17742882C>A	ENST00000250003.3	+	3	1005	c.790C>A	c.(790-792)Cct>Act	p.P264T		NM_002478.4	NP_002469.2	P15172	MYOD1_HUMAN	myogenic differentiation 1	264					muscle cell fate commitment|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|protein phosphorylation|skeletal muscle tissue development	nuclear chromatin|transcription factor complex	E-box binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription coactivator activity	p.P264T(1)		breast(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)	17						CACCGAGAGCCCTGCGGCGCC	0.726000													5	10					1.23904e-05	1.48639e-05	0.184627	1	0
MUC16	94025	broad.mit.edu	37	19	9064152	9064152	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:9064152G>A	ENST00000397910.4	-	3	23497	c.23294C>T	c.(23293-23295)gCc>gTc	p.A7765V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7767	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.A7765V(2)|p.A3398V(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGATGCACGGCTTCTGTATG	0.488000													70	81					0	0	0.870114	0	0
OR5D14	219436	broad.mit.edu	37	11	55563359	55563359	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:55563359G>T	ENST00000335605.1	+	1	328	c.328G>T	c.(328-330)Gtg>Ttg	p.V110L		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V110L(1)		breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				CTGCACTGCTGTGGTGACAGA	0.488000													16	21					3.45872e-05	4.09618e-05	0.500413	1	0
MAP3K14	9020	broad.mit.edu	37	17	43368045	43368045	+	RNA	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:43368045G>A	ENST00000344686.2	-	0	175							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding	p.P23S(1)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TTGGCTTTGGGGAGTTCCTTC	0.592000													14	27					0	0	0.500413	0	0
PANX1	24145	broad.mit.edu	37	11	93912816	93912816	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:93912816G>T	ENST00000227638.3	+	4	979	c.594G>T	c.(592-594)caG>caT	p.Q198H	PANX1_ENST00000436171.2_Missense_Mutation_p.Q198H	NM_015368.3	NP_056183.2	Q96RD7	PANX1_HUMAN	pannexin 1	198					positive regulation of interleukin-1 beta secretion|protein hexamerization|synaptic transmission	bleb|endoplasmic reticulum membrane|gap junction|integral to membrane	calcium channel activity|gap junction hemi-channel activity|leak channel activity|receptor binding	p.Q198H(1)		endometrium(2)|large_intestine(2)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TTGTGGAGCAGTACTTGAAGA	0.368000													7	13					1.06961e-07	1.39393e-07	0.278610	1	0
PCMTD1	115294	broad.mit.edu	37	8	52733190	52733190	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:52733190G>T	ENST00000360540.5	-	7	1201	c.795C>A	c.(793-795)gcC>gcA	p.A265A	PCMTD1_ENST00000519559.1_5'UTR|PCMTD1_ENST00000544451.1_Silent_p.A189A|PCMTD1_ENST00000522514.1_Silent_p.A265A	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	265						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	p.A265A(1)		NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				GAATCCCCTTGGCCTGCATCT	0.418000													5	122					4.68919e-08	6.17299e-08	0.361761	1	0
LRP2	4036	broad.mit.edu	37	2	170002265	170002265	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:170002265T>C	ENST00000263816.3	-	70	13265	c.12980A>G	c.(12979-12981)aAt>aGt	p.N4327S		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	4327					hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding	p.N4327S(1)		biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACCTGACTTATTGTATCTGAG	0.363000													19	43					0	0	0.575678	0	0
MMRN1	22915	broad.mit.edu	37	4	90833201	90833201	+	Splice_Site	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:90833201G>T	ENST00000394980.1	+	4	1169	c.850_splice	c.e4+1	p.A284_splice	MMRN1_ENST00000508372.1_Splice_Site_p.A26_splice|MMRN1_ENST00000264790.2_Splice_Site_p.A284_splice|MMRN1_ENST00000394981.1_Splice_Site_p.A250_splice			Q13201	MMRN1_HUMAN	multimerin 1	284					cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen		p.A284S(1)		breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|liver(2)|lung(34)|ovary(5)|prostate(1)|skin(6)|stomach(1)|urinary_tract(2)	72		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		TCAACTAAGAGGTACACTCTA	0.358000													7	10					0.0293803	0.0303628	0.248553	1	0
TBC1D32	221322	broad.mit.edu	37	6	121642831	121642831	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:121642831C>A	ENST00000275159.6	-	2	264	c.265G>T	c.(265-267)Ggc>Tgc	p.G89C	TBC1D32_ENST00000398212.2_Missense_Mutation_p.G89C					TBC1 domain family, member 32									p.G89C(1)									GTATCATAGCCGCATTCTTCA	0.383000													34	122					3.03874e-20	5.49343e-20	0.779181	1	0
NLGN4X	57502	broad.mit.edu	37	X	5821830	5821830	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:5821830T>A	ENST00000381095.3	-	5	1516	c.889A>T	c.(889-891)Act>Tct	p.T297S	NLGN4X_ENST00000538097.1_Missense_Mutation_p.T297S|NLGN4X_ENST00000275857.6_Missense_Mutation_p.T297S|NLGN4X_ENST00000381092.1_Missense_Mutation_p.T297S|NLGN4X_ENST00000381093.2_Missense_Mutation_p.T317S	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	297					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity	p.T297S(1)		breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						AATATCCGAGTGTACTTGGCC	0.557000													18	20					0	0	0.575678	0	0
SPATA6	54558	broad.mit.edu	37	1	48918776	48918776	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:48918776C>G	ENST00000371847.3	-	2	243	c.79G>C	c.(79-81)Gac>Cac	p.D27H	SPATA6_ENST00000463938.1_5'UTR|SPATA6_ENST00000396199.3_5'UTR|SPATA6_ENST00000371843.3_Missense_Mutation_p.D27H	NM_019073.2	NP_061946.1	Q9NWH7	SPAT6_HUMAN	spermatogenesis associated 6	27					cell differentiation|multicellular organismal development|spermatogenesis	extracellular region		p.D27H(2)		breast(1)|endometrium(2)|large_intestine(6)|lung(7)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	21						TCCTCTTTGTCTTTAAGCACG	0.388000													9	51					0	0	0.335167	0	0
CELF1	10658	broad.mit.edu	37	11	47506016	47506016	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:47506016T>C	ENST00000395290.2	-	4	376	c.367A>G	c.(367-369)Atc>Gtc	p.I123V	CELF1_ENST00000310513.5_Missense_Mutation_p.I124V|CELF1_ENST00000361904.3_Missense_Mutation_p.I124V|CELF1_ENST00000395292.2_Missense_Mutation_p.I124V|CELF1_ENST00000358597.3_Missense_Mutation_p.I124V|CELF1_ENST00000532048.1_Missense_Mutation_p.I150V|CELF1_ENST00000531165.1_Missense_Mutation_p.I151V	NM_001025596.2|NM_001172640.1	NP_001020767.1|NP_001166111.1	Q92879	CELF1_HUMAN	CUGBP, Elav-like family member 1	124	RRM 2.				embryo development|mRNA splice site selection|regulation of RNA splicing|RNA interference	cytoplasm|nucleus|ribonucleoprotein complex	BRE binding|mRNA binding|nucleotide binding|translation repressor activity, nucleic acid binding	p.I124V(1)		central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)	18						ATGACTCGGATGTCATTTTCA	0.403000													21	38					0	0	0.592651	0	0
SLC4A3	6508	broad.mit.edu	37	2	220494042	220494042	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:220494042G>T	ENST00000358055.3	+	4	906	c.394G>T	c.(394-396)Gct>Tct	p.A132S	SLC4A3_ENST00000497589.1_3'UTR|SLC4A3_ENST00000373760.2_Missense_Mutation_p.A132S|SLC4A3_ENST00000373762.3_Missense_Mutation_p.A132S|SLC4A3_ENST00000317151.3_Missense_Mutation_p.A132S|SLC4A3_ENST00000273063.6_Missense_Mutation_p.A132S			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	132					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity	p.A132S(1)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGAGGGGGGAGCTGGAGTgga	0.622000													9	21					0.000274275	0.000311742	0.307466	1	0
FRG1B	284802	broad.mit.edu	37	20	29623193	29623193	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:29623193G>T	ENST00000278882.3	+	3	385	c.5G>T	c.(4-6)aGg>aTg	p.R2M	FRG1B_ENST00000439954.2_Missense_Mutation_p.E3D|FRG1B_ENST00000358464.4_Missense_Mutation_p.R2M														p.R2M(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AAATGGATGAGGGAACCTATA	0.378000													12	529					4.36969e-10	6.28809e-10	0.435327	1	0
COL21A1	81578	broad.mit.edu	37	6	56021688	56021688	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:56021688C>T	ENST00000244728.5	-	10	1828	c.1431G>A	c.(1429-1431)aaG>aaA	p.K477K	COL21A1_ENST00000370819.1_Silent_p.K474K|COL21A1_ENST00000535941.1_Silent_p.K477K	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	477	Collagen-like 1.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.K477K(2)		breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TACTCACAGGCTTACCATCTT	0.448000													4	8					0	0	0.150653	0	0
UNC45A	55898	broad.mit.edu	37	15	91489890	91489890	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:91489890C>T	ENST00000394275.2	+	13	2036	c.1201C>T	c.(1201-1203)Cag>Tag	p.Q401*	UNC45A_ENST00000418476.2_Nonsense_Mutation_p.Q416*	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	416					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding	p.Q416*(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			ACGGGCCATCCAGACGGTGTC	0.622000													4	13					0	0	0.150653	0	0
ARPP21	10777	broad.mit.edu	37	3	35781039	35781039	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:35781039G>C	ENST00000187397.4	+	17	2331	c.1875G>C	c.(1873-1875)caG>caC	p.Q625H	ARPP21_ENST00000417925.1_Missense_Mutation_p.Q626H|ARPP21_ENST00000337271.5_Missense_Mutation_p.Q606H|ARPP21_ENST00000458225.1_Missense_Mutation_p.Q626H|ARPP21_ENST00000444190.1_Missense_Mutation_p.Q606H	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	625	Gln-rich.					cytoplasm	nucleic acid binding	p.Q625H(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						CCTCACCACAGGGATTTGTGC	0.547000													5	33					0	0	0.217242	0	0
CELSR3	1951	broad.mit.edu	37	3	48697761	48697761	+	Silent	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:48697761T>A	ENST00000544264.1	-	1	2587	c.2307A>T	c.(2305-2307)gcA>gcT	p.A769A	CELSR3_ENST00000164024.4_Silent_p.A769A			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	769	Cadherin 5.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding	p.A769A(1)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGCCCACAGCTGCATCCTCAT	0.557000													14	34					0	0	0.457914	0	0
C5orf42	65250	broad.mit.edu	37	5	37187517	37187517	+	Splice_Site	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:37187517T>A	ENST00000274258.7	-	23	4309	c.723_splice	c.e23+1	p.K241_splice	C5orf42_ENST00000425232.2_Splice_Site_p.K1360_splice|C5orf42_ENST00000508244.1_Splice_Site_p.K1360_splice			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1360								p.K1360M(1)|p.K241M(1)		breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			GCACATTACCTTTCTGATTGG	0.328000													17	110					0	0	0.520397	0	0
GPR12	2835	broad.mit.edu	37	13	27333191	27333191	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:27333191C>A	ENST00000405846.3	-	2	995	c.774G>T	c.(772-774)ggG>ggT	p.G258G	GPR12_ENST00000381436.2_Silent_p.G258G	NM_005288.3	NP_005279.1	P47775	GPR12_HUMAN	G protein-coupled receptor 12	258						integral to plasma membrane		p.G258G(1)		endometrium(7)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		CAGCAAACGTCCCCAGGATGA	0.587000													12	14					3.07112e-06	3.76778e-06	0.387290	1	0
ERBB4	2066	broad.mit.edu	37	2	212522507	212522507	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:212522507C>A	ENST00000342788.4	-	16	2228	c.1918G>T	c.(1918-1920)Ggc>Tgc	p.G640C	ERBB4_ENST00000436443.1_Missense_Mutation_p.G640C|ERBB4_ENST00000402597.1_Intron	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	640					cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.G640C(1)		NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GTGGAATGGCCCGTCCATGGG	0.428000										TSP Lung(8;0.080)			15	40					2.61681e-11	3.95877e-11	0.457914	1	0
CLCN1	1180	broad.mit.edu	37	7	143036384	143036384	+	Silent	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:143036384C>T	ENST00000343257.2	+	13	1527	c.1440C>T	c.(1438-1440)ccC>ccT	p.P480P		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	480			P -> L (in THD).		muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity	p.P480P(1)		breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					TGCCCATACCCTGCGGAGGCT	0.488000													67	142					0	0	0.870114	0	0
CDH19	28513	broad.mit.edu	37	18	64212068	64212068	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr18:64212068T>C	ENST00000262150.2	-	6	1140	c.848A>G	c.(847-849)aAt>aGt	p.N283S	CDH19_ENST00000540086.1_Missense_Mutation_p.N283S	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	283	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.N283S(1)		NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				TCCTATGTCATTATCATATGC	0.358000													9	15					0	0	0.307466	0	0
MARCO	8685	broad.mit.edu	37	2	119727765	119727765	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:119727765C>A	ENST00000541757.1	+	4	421	c.41C>A	c.(40-42)cCg>cAg	p.P14Q	MARCO_ENST00000327097.4_Missense_Mutation_p.P92Q			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	92					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity	p.P92K(1)		breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						GAGGACAGCCCGTCCTTCTCC	0.617000													12	40					1.5842e-08	2.13752e-08	0.435327	1	0
SGIP1	84251	broad.mit.edu	37	1	67155937	67155937	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:67155937C>A	ENST00000371037.4	+	17	1585	c.1508C>A	c.(1507-1509)gCt>gAt	p.A503D	SGIP1_ENST00000371035.3_Missense_Mutation_p.A293D|SGIP1_ENST00000371036.3_Missense_Mutation_p.A303D|SGIP1_ENST00000371039.1_Missense_Mutation_p.A304D|SGIP1_ENST00000237247.6_Missense_Mutation_p.A534D	NM_032291.2	NP_115667.2	Q9BQI5	SGIP1_HUMAN	SH3-domain GRB2-like (endophilin) interacting protein 1	503					positive regulation of energy homeostasis|positive regulation of feeding behavior|positive regulation of receptor-mediated endocytosis|response to dietary excess	AP-2 adaptor complex	microtubule binding|phospholipid binding|SH3 domain binding	p.A304D(1)|p.A503D(1)		breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(43)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	71						TTAGCGCGGGCTGAAAGCACT	0.458000													23	91					1.66031e-10	2.416e-10	0.667858	1	0
DLGAP1	9229	broad.mit.edu	37	18	3502601	3502601	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr18:3502601C>A	ENST00000315677.3	-	12	3209	c.2614G>T	c.(2614-2616)Ggg>Tgg	p.G872W	DLGAP1_ENST00000515196.2_Missense_Mutation_p.G872W|DLGAP1_ENST00000534970.1_Missense_Mutation_p.G556W|DLGAP1_ENST00000584874.1_Missense_Mutation_p.G872W|DLGAP1_ENST00000581527.1_Missense_Mutation_p.G872W|DLGAP1_ENST00000581699.1_Missense_Mutation_p.G578W|DLGAP1_ENST00000539435.1_Missense_Mutation_p.G580W|DLGAP1_ENST00000400145.2_Missense_Mutation_p.G570W|DLGAP1_ENST00000400147.2_Missense_Mutation_p.G570W|DLGAP1_ENST00000400149.3_Missense_Mutation_p.G562W|DLGAP1_ENST00000400150.3_Missense_Mutation_p.G588W|DLGAP1_ENST00000400155.1_Missense_Mutation_p.G578W	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	872					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.G872W(1)|p.G580W(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				TCCCAAAACCCCGCCAAATCC	0.408000													22	41					1.1804e-14	1.95428e-14	0.667858	1	0
AHDC1	27245	broad.mit.edu	37	1	27877205	27877205	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:27877205C>A	ENST00000374011.2	-	6	2390	c.1422G>T	c.(1420-1422)atG>atT	p.M474I	AHDC1_ENST00000482400.2_Intron|AHDC1_ENST00000247087.5_Missense_Mutation_p.M474I	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	474							DNA binding	p.M474I(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		TCTTCACCACCATGCGCCGCA	0.627000													11	12					3.03607e-14	4.91374e-14	0.411799	1	0
TUBB2B	347733	broad.mit.edu	37	6	3225005	3225005	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:3225005C>T	ENST00000259818.7	-	4	1509	c.1318G>A	c.(1318-1320)Gag>Aag	p.E440K	TUBB2B_ENST00000473006.1_5'UTR	NM_178012.4	NP_821080.1	Q9BVA1	TBB2B_HUMAN	tubulin, beta 2B class IIb	440					'de novo' posttranslational protein folding|microtubule-based movement|neuron migration|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity	p.E440K(1)		kidney(2)|large_intestine(5)|lung(1)|prostate(1)|skin(1)	10	Ovarian(93;0.0386)	all_hematologic(90;0.108)				TCCTCGCCCTCCTCCTCCTCG	0.652000													18	38					0	0	0.624587	0	0
MYO16	23026	broad.mit.edu	37	13	109318301	109318301	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:109318301C>A	ENST00000356711.2	+	2	156	c.30C>A	c.(28-30)tcC>tcA	p.S10S	MYO16_ENST00000251041.5_Silent_p.S10S|MYO16_ENST00000357550.2_Silent_p.S10S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	10					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity	p.S10S(1)		NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TGCTAGAGTCCCTTCCCCTTG	0.522000													13	20					4.3838e-07	5.56768e-07	0.435327	1	0
FBN2	2201	broad.mit.edu	37	5	127641291	127641291	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:127641291C>A	ENST00000508053.1	-	50	6560	c.5586G>T	c.(5584-5586)caG>caT	p.Q1862H	FBN2_ENST00000262464.4_Missense_Mutation_p.Q1862H			P35556	FBN2_HUMAN	fibrillin 2	1862	EGF-like 30; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent	p.Q1862H(2)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CTGCATTCCGCTGGCAGAGAT	0.428000													27	44					1.68575e-08	2.26044e-08	0.717897	1	0
GNAS	2778	broad.mit.edu	37	20	57429321	57429321	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:57429321G>T	ENST00000371100.4	+	1	1553	c.1001G>T	c.(1000-1002)gGc>gTc	p.G334V	GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371099.2_Missense_Mutation_p.G334V|GNAS_ENST00000306120.3_Missense_Mutation_p.A271S|GNAS_ENST00000371102.4_Missense_Mutation_p.G334V|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000603534.1_Intron|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371075.3_Intron	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity	p.G334V(1)		adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCGCTTGACGGCCCGCCCATC	0.642000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			3	6					0.00024832	0.000283732	0.150653	1	0
CDH10	1008	broad.mit.edu	37	5	24509706	24509706	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:24509706T>C	ENST00000264463.4	-	7	1732	c.1225A>G	c.(1225-1227)Agg>Ggg	p.R409G		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	409	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R409G(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TCTGGGTCCCTTGCCATTACA	0.453000										HNSCC(23;0.051)			20	83					0	0	0.592651	0	0
DYNC1I1	1780	broad.mit.edu	37	7	95662065	95662065	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:95662065G>T	ENST00000324972.6	+	12	1447	c.1254G>T	c.(1252-1254)tgG>tgT	p.W418C	DYNC1I1_ENST00000457059.1_Missense_Mutation_p.W401C|DYNC1I1_ENST00000447467.2_Missense_Mutation_p.W401C|DYNC1I1_ENST00000437599.1_Missense_Mutation_p.W398C|DYNC1I1_ENST00000497626.1_3'UTR|DYNC1I1_ENST00000359388.4_Missense_Mutation_p.W381C|DYNC1I1_ENST00000537881.1_Missense_Mutation_p.W381C	NM_004411.4	NP_004402.1	O14576	DC1I1_HUMAN	dynein, cytoplasmic 1, intermediate chain 1	418					vesicle transport along microtubule	condensed chromosome kinetochore|cytoplasmic dynein complex|microtubule|perinuclear region of cytoplasm|spindle pole|vesicle	microtubule binding|microtubule motor activity	p.W418C(1)		NS(2)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(27)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	54	all_cancers(62;9.39e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.165)|all_lung(186;0.191)		STAD - Stomach adenocarcinoma(171;0.0957)			TGTGTTCCTGGAGCCTGGACA	0.438000													28	64					1.68575e-08	2.26044e-08	0.717897	1	0
FYB	2533	broad.mit.edu	37	5	39202797	39202797	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:39202797C>A	ENST00000351578.6	-	2	456	c.266G>T	c.(265-267)gGc>gTc	p.G89V	FYB_ENST00000512982.1_Missense_Mutation_p.G89V|FYB_ENST00000540520.1_Missense_Mutation_p.G99V|FYB_ENST00000515010.1_Missense_Mutation_p.G89V|FYB_ENST00000505428.1_Missense_Mutation_p.G89V	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	89					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding	p.G89V(3)|p.G99V(1)		endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			GAATCTTTGGCCTGCTCCAGT	0.547000													25	18					5.61819e-17	9.67163e-17	0.693898	1	0
LAMA2	3908	broad.mit.edu	37	6	129465106	129465106	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:129465106G>A	ENST00000421865.2	+	5	749	c.700G>A	c.(700-702)Gaa>Aaa	p.E234K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	234	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.E234K(1)		NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AGAACTGCTAGAATTTACCTC	0.393000													16	49					0	0	0.539581	0	0
LRRC40	55631	broad.mit.edu	37	1	70618156	70618156	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:70618156C>A	ENST00000370952.3	-	12	1478	c.1399G>T	c.(1399-1401)Gag>Tag	p.E467*		NM_017768.4	NP_060238.3	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	467								p.E467*(1)		breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(2)	27						ACACATAACTCCAAGGATATA	0.289000													14	19					9.16793e-09	1.24477e-08	0.520397	1	0
GPR112	139378	broad.mit.edu	37	X	135429209	135429209	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:135429209G>C	ENST00000394143.1	+	6	3635	c.3344G>C	c.(3343-3345)aGa>aCa	p.R1115T	GPR112_ENST00000412101.1_Missense_Mutation_p.R910T|GPR112_ENST00000287534.4_Missense_Mutation_p.R1052T|GPR112_ENST00000394141.1_Missense_Mutation_p.R910T|GPR112_ENST00000370652.1_Missense_Mutation_p.R1115T	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1115					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R1115T(1)		NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CATTCACTGAGACTCTCCACT	0.478000													47	36					0	0	0.870114	0	0
MARS2	92935	broad.mit.edu	37	2	198571470	198571470	+	Nonsense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:198571470T>A	ENST00000282276.6	+	1	1384	c.1341T>A	c.(1339-1341)taT>taA	p.Y447*	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	447					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity	p.Y447*(1)		breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	CAGAGGATTATGCTCTGGTGA	0.542000													29	75					0	0	0.706142	0	0
WASF1	8936	broad.mit.edu	37	6	110428292	110428292	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:110428292C>A	ENST00000392589.1	-	7	1364	c.528G>T	c.(526-528)aaG>aaT	p.K176N	WASF1_ENST00000392587.2_Missense_Mutation_p.K176N|WASF1_ENST00000359451.2_Missense_Mutation_p.K176N|WASF1_ENST00000392586.1_Missense_Mutation_p.K176N|WASF1_ENST00000392588.1_Missense_Mutation_p.K176N	NM_003931.2	NP_003922.1	Q92558	WASF1_HUMAN	WAS protein family, member 1	176					actin filament polymerization|cellular component movement	actin cytoskeleton	actin binding	p.K176N(1)		breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(87;1.18e-05)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00159)|Colorectal(196;0.0488)		OV - Ovarian serous cystadenocarcinoma(136;0.0364)|Epithelial(106;0.051)|all cancers(137;0.0687)		TCTGCTTCCTCTTTTCCTTCC	0.294000													12	41					0.000151284	0.000176272	0.435327	1	0
PCDHB12	56124	broad.mit.edu	37	5	140590567	140590567	+	Silent	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:140590567A>G	ENST00000239450.2	+	1	2277	c.2088A>G	c.(2086-2088)tcA>tcG	p.S696S	PCDHB12_ENST00000541609.1_Silent_p.S359S	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		696					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGTTGGCCTCAGTGTCGTCGC	0.706000													17	212					0	0	0.788014	0	0
SPEG	10290	broad.mit.edu	37	2	220354290	220354290	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:220354290G>A	ENST00000312358.7	+	36	8682	c.8550G>A	c.(8548-8550)agG>agA	p.R2850R	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2850	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity	p.R2850R(1)		breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GAAGACACAGGGGCCTGCAGG	0.657000													35	76					0	0	0.788014	0	0
TGFB2	7042	broad.mit.edu	37	1	218610720	218610720	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:218610720A>G	ENST00000366929.4	+	7	1519	c.1052A>G	c.(1051-1053)tAc>tGc	p.Y351C	TGFB2_ENST00000479322.1_3'UTR|TGFB2_ENST00000366930.4_Missense_Mutation_p.Y323C	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	323					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding	p.Y323C(1)|p.Y351C(1)		breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		CGTCCACTTTACATTGATTTC	0.408000													24	58					0	0	0.667858	0	0
DNAJC1	64215	broad.mit.edu	37	10	22207776	22207776	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:22207776C>G	ENST00000376980.3	-	6	951	c.661G>C	c.(661-663)Gat>Cat	p.D221H		NM_022365.3	NP_071760.2	Q96KC8	DNJC1_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 1	221					negative regulation of proteolysis|regulation of protein secretion|regulation of transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	ATPase activator activity|DNA binding|heat shock protein binding|unfolded protein binding	p.D221H(1)		cervix(1)|endometrium(1)|large_intestine(2)|lung(13)|skin(2)|upper_aerodigestive_tract(2)	21		Breast(68;0.00869)|Prostate(175;0.0181)|Lung SC(717;0.0262)				GGAAGCAAATCATGCCACTGT	0.373000													11	21					0	0	0.411799	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814054	106814054	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:106814054C>G	ENST00000407775.2	+	8	1994	c.1744C>G	c.(1744-1746)Cca>Gca	p.P582A	RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.P450A|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.P313A|ZFPM2_ENST00000520492.1_Missense_Mutation_p.P450A|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000521622.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	582					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding	p.P582A(1)		NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GGCTAAGTCCCCAGAGTTCCC	0.433000													33	99					0	0	0.796494	0	0
CCR3	1232	broad.mit.edu	37	3	46307361	46307361	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:46307361A>G	ENST00000357422.2	+	4	1255	c.712A>G	c.(712-714)Atc>Gtc	p.I238V	CCR3_ENST00000545097.1_Missense_Mutation_p.I259V|CCR3_ENST00000395940.2_Missense_Mutation_p.I238V|CCR3_ENST00000395942.2_Missense_Mutation_p.I238V|CCR3_ENST00000541018.1_Missense_Mutation_p.I238V			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	238					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane		p.I238V(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		GTACAAGGCCATCCGGCTCAT	0.448000													19	36					0	0	0.575678	0	0
TRIL	9865	broad.mit.edu	37	7	28996417	28996417	+	RNA	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:28996417C>A	ENST00000322982.3	-	0	1517							Q7L0X0	TRIL_HUMAN	TLR4 interactor with leucine-rich repeats						inflammatory response|innate immune response|regulation of cytokine production involved in immune response|toll-like receptor 4 signaling pathway	lipopolysaccharide receptor complex	lipopolysaccharide binding										GGCGAGGGATCCGCGCAGGAT	0.662000													16	43					3.32936e-07	4.25345e-07	0.539581	1	0
VTCN1	79679	broad.mit.edu	37	1	117699283	117699283	+	Missense_Mutation	SNP	C	C	T	rs144508898	by1000genomes	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:117699283C>T	ENST00000369458.3	-	3	436	c.358G>A	c.(358-360)Gtg>Atg	p.V120M	VTCN1_ENST00000463461.1_5'UTR|VTCN1_ENST00000539893.1_Missense_Mutation_p.V25M|VTCN1_ENST00000359008.4_Missense_Mutation_p.V123M|VTCN1_ENST00000328189.3_Intron	NM_024626.3	NP_078902.2	Q7Z7D3	VTCN1_HUMAN	V-set domain containing T cell activation inhibitor 1	120	Ig-like V-type 1.					integral to membrane|plasma membrane		p.V120M(1)		large_intestine(7)|lung(4)|upper_aerodigestive_tract(1)	12	Lung SC(450;0.225)	all_cancers(81;6.05e-06)|all_epithelial(167;5.59e-07)|all_lung(203;2.85e-06)|Lung NSC(69;2e-05)		Lung(183;0.0664)|LUSC - Lung squamous cell carcinoma(189;0.214)|Colorectal(144;0.23)		GTGAGTTGCACGTTTTTCAGC	0.448000													6	54					0	0	0.335167	0	0
GRXCR1	389207	broad.mit.edu	37	4	43032470	43032470	+	Silent	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:43032470A>T	ENST00000399770.2	+	4	786	c.786A>T	c.(784-786)cgA>cgT	p.R262R		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	262					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity	p.R262L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						CCATGTTTCGAAACTGCTTCA	0.468000													47	101					0	0	0.870114	0	0
BBX	56987	broad.mit.edu	37	3	107524268	107524268	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:107524268G>T	ENST00000416476.2	+	17	2001	c.1781G>T	c.(1780-1782)cGc>cTc	p.R594L	BBX_ENST00000402543.1_Silent_p.P880P|BBX_ENST00000406780.1_Silent_p.P900P|BBX_ENST00000415149.2_Silent_p.P900P|BBX_ENST00000325805.8_Silent_p.P930P			Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.P900P(1)		breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			AAGAAATGCCGCAGGCTCCTG	0.443000													33	82					6.53348e-20	1.17458e-19	0.788014	1	0
SCNN1B	6338	broad.mit.edu	37	16	23364156	23364156	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:23364156G>T	ENST00000343070.2	+	3	522	c.346G>T	c.(346-348)Gat>Tat	p.D116Y	SCNN1B_ENST00000568923.1_Missense_Mutation_p.D116Y|SCNN1B_ENST00000307331.5_Missense_Mutation_p.D161Y|SCNN1B_ENST00000568085.1_Missense_Mutation_p.D116Y|SCNN1B_ENST00000569789.1_3'UTR	NM_000336.2	NP_000327.2	P51168	SCNNB_HUMAN	sodium channel, non-voltage-gated 1, beta subunit	116					excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding	p.D116Y(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	GAAGGACCTGGATGAGCTGAT	0.502000													26	42					1.42536e-11	2.17149e-11	0.681144	1	0
OR13G1	441933	broad.mit.edu	37	1	247836335	247836335	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:247836335G>T	ENST00000359688.2	-	1	30	c.9C>A	c.(7-9)caC>caA	p.H3Q	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H3Q(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TTACAACGCTGTGATTCATCC	0.403000													11	41					2.27111e-07	2.91871e-07	0.411799	1	0
CACNA1B	774	broad.mit.edu	37	9	140850264	140850264	+	Splice_Site	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:140850264G>T	ENST00000371372.1	+	8	1330	c.1186_splice	c.e8+1	p.A395_splice	CACNA1B_ENST00000371363.1_Splice_Site_p.A395_splice|CACNA1B_ENST00000277551.2_Splice_Site_p.A395_splice|CACNA1B_ENST00000371355.4_Splice_Site_p.A395_splice|CACNA1B_ENST00000371357.1_Splice_Site_p.A395_splice|CACNA1B_ENST00000277549.5_5'UTR	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	395	Binding to the beta subunit (By similarity).				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity	p.A395A(1)		NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	TCTTCAAGGCGGGTGAGGGCC	0.657000													11	2					0.010729	0.0113222	0.387290	1	0
ARHGAP17	55114	broad.mit.edu	37	16	24981854	24981854	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:24981854C>A	ENST00000289968.6	-	4	315	c.246G>T	c.(244-246)tcG>tcT	p.S82S	ARHGAP17_ENST00000575975.1_5'UTR|ARHGAP17_ENST00000303665.5_Silent_p.S82S|ARHGAP17_ENST00000441763.2_Silent_p.S82S	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	82	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding	p.S82S(2)		breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		CCAGCTGAGTCGATGCTTCTT	0.463000													55	156					5.86059e-21	1.07141e-20	0.870114	1	0
CLDN8	9073	broad.mit.edu	37	21	31588044	31588044	+	Missense_Mutation	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:31588044T>C	ENST00000399899.1	-	1	347	c.200A>G	c.(199-201)tAt>tGt	p.Y67C	CLDN8_ENST00000286809.1_Missense_Mutation_p.Y67C	NM_199328.2	NP_955360.1	P56748	CLD8_HUMAN	claudin 8	67					calcium-independent cell-cell adhesion	endoplasmic reticulum|integral to membrane|tight junction	identical protein binding|structural molecule activity	p.Y67C(1)		NS(1)|endometrium(2)|large_intestine(6)|lung(6)	15						CAGGGAATCATAGATTTTGCA	0.488000													21	67					0	0	0.592651	0	0
TAF1L	138474	broad.mit.edu	37	9	32631092	32631092	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:32631092A>T	ENST00000242310.4	-	1	4575	c.4486T>A	c.(4486-4488)Tgt>Agt	p.C1496S		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1496					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding	p.C1496S(1)		breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTTTCATCACAGAGATCCAGC	0.408000													36	104					0	0	0.779181	0	0
LRP1B	53353	broad.mit.edu	37	2	141680663	141680663	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:141680663C>T	ENST00000389484.3	-	21	4161	c.3190G>A	c.(3190-3192)Ggt>Agt	p.G1064S		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1064	LDL-receptor class A 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.G1064S(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACGCAATTACCATCAGGGTGG	0.443000										TSP Lung(27;0.18)			15	48					0	0	0.457914	0	0
EFCAB5	374786	broad.mit.edu	37	17	28380557	28380557	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:28380557G>T	ENST00000394835.3	+	10	1777	c.1585G>T	c.(1585-1587)Ggc>Tgc	p.G529C	EFCAB5_ENST00000394832.2_Missense_Mutation_p.G529C|EFCAB5_ENST00000378738.3_Missense_Mutation_p.G529C|EFCAB5_ENST00000320856.5_Missense_Mutation_p.G529C|EFCAB5_ENST00000541045.1_Missense_Mutation_p.G186C|EFCAB5_ENST00000536908.2_Missense_Mutation_p.G473C	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	529							calcium ion binding	p.G529C(1)		breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						ACAACAACAAGGCAAAAAGCC	0.428000													10	23					6.40141e-05	7.53996e-05	0.387290	1	0
IGKV1-8	28942	broad.mit.edu	37	2	89292386	89292386	+	RNA	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:89292386G>A	ENST00000495489.1	-	0	64																											GGAGCTGAGCGGGGACCCTCA	0.562000													35	90					0	0	0.840704	0	0
INHBA	3624	broad.mit.edu	37	7	41730000	41730000	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:41730000G>C	ENST00000242208.4	-	3	775	c.529C>G	c.(529-531)Cag>Gag	p.Q177E	INHBA_ENST00000442711.1_Missense_Mutation_p.Q177E|INHBA_ENST00000464515.1_5'UTR|AC005027.3_ENST00000416150.1_RNA	NM_002192.2	NP_002183.1	P08476	INHBA_HUMAN	inhibin, beta A	177					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity	p.Q177E(1)		biliary_tract(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(15)|lung(26)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						TTCTGCTGCTGGAAGAGGCGG	0.572000										TSP Lung(11;0.080)			19	55					0	0	0.654019	0	0
KDELC1	79070	broad.mit.edu	37	13	103443386	103443386	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:103443386T>A	ENST00000376004.4	-	6	1284	c.948A>T	c.(946-948)agA>agT	p.R316S	KDELC1_ENST00000460338.1_5'UTR	NM_024089.2	NP_076994.2	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1	316						endoplasmic reticulum lumen		p.R316S(1)		central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					CCAGCTCGAGTCTCTCTTTGC	0.478000													15	32					0	0	0.500413	0	0
STK38	11329	broad.mit.edu	37	6	36485593	36485593	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:36485593C>A	ENST00000229812.7	-	6	700	c.415G>T	c.(415-417)Gac>Tac	p.D139Y		NM_007271.2	NP_009202.1	Q15208	STK38_HUMAN	serine/threonine kinase 38	139	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity	p.D139Y(1)		NS(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						ACTAGAATGTCACGCTCCGCA	0.403000													17	59					9.7654e-05	0.000114194	0.557998	1	0
COL7A1	1294	broad.mit.edu	37	3	48612109	48612109	+	Splice_Site	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:48612109C>G	ENST00000328333.8	-	77	6501		c.e77+1		COL7A1_ENST00000454817.1_Splice_Site	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1						cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity	p.?(2)		NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		AGAGGCCTCACCCTGTCTCCT	0.632000													17	43					0	0	0.520397	0	0
OR13D1	286365	broad.mit.edu	37	9	107457241	107457241	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:107457241C>A	ENST00000318763.5	+	1	582	c.539C>A	c.(538-540)tCc>tAc	p.S180Y		NM_001004484.1	NP_001004484.1	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D, member 1	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S180Y(1)		large_intestine(4)|lung(10)|ovary(1)|prostate(2)|skin(2)	19						GCTGCATGGTCCTGGATCATA	0.463000													19	81					5.3912e-06	6.55223e-06	0.539581	1	0
KDR	3791	broad.mit.edu	37	4	55976691	55976691	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:55976691T>A	ENST00000263923.4	-	9	1429	c.1134A>T	c.(1132-1134)aaA>aaT	p.K378N		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	378	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.K378N(1)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CATGCCCCGCTTTAATTGTGT	0.388000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			25	40					0	0	0.693898	0	0
UMODL1	89766	broad.mit.edu	37	21	43531679	43531679	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:43531679C>T	ENST00000400427.1	+	11	2527	c.2131C>T	c.(2131-2133)Cac>Tac	p.H711Y	UMODL1_ENST00000408989.2_Missense_Mutation_p.H783Y|UMODL1_ENST00000400424.1_Missense_Mutation_p.H583Y|UMODL1_ENST00000408910.2_Missense_Mutation_p.H655Y	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	708	Fibronectin type-III 2.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity	p.H783Y(1)|p.H583Y(1)		breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CCCCACCGGCCACTTCCTGTG	0.627000													17	22					0	0	0.500413	0	0
ASTN2	23245	broad.mit.edu	37	9	119858355	119858355	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:119858355G>T	ENST00000313400.4	-	5	1344	c.1244C>A	c.(1243-1245)aCg>aAg	p.T415K	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Missense_Mutation_p.T415K|ASTN2_ENST00000361209.2_Missense_Mutation_p.T364K			O75129	ASTN2_HUMAN	astrotactin 2	415						integral to membrane		p.T364K(1)		breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						GTACTGCTCCGTGTAGAATGT	0.507000													10	44					7.03913e-09	9.69935e-09	0.411799	1	0
RYR1	6261	broad.mit.edu	37	19	39008322	39008322	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:39008322C>T	ENST00000355481.4	+	66	10140	c.10009C>T	c.(10009-10011)Cgg>Tgg	p.R3337W	RYR1_ENST00000359596.3_Missense_Mutation_p.R3337W|RYR1_ENST00000360985.3_Missense_Mutation_p.R3337W	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	3337					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.R3337W(1)		NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTGGATGAAGCGGCTGGCTGG	0.622000													6	40					0	0	0.278610	0	0
KIAA0368	23392	broad.mit.edu	37	9	114188022	114188022	+	Splice_Site	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:114188022C>T	ENST00000259335.4	-	12	1670		c.e12+1		KIAA0368_ENST00000338205.5_Splice_Site	NM_001080398.1	NP_001073867.1			KIAA0368									p.?(1)		NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						TAAAGACTTACGTTATACAAA	0.308000													4	60					0	0	0.184627	0	0
SPACA1	81833	broad.mit.edu	37	6	88773885	88773885	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:88773885G>T	ENST00000237201.1	+	6	796	c.679G>T	c.(679-681)Gtc>Ttc	p.V227F	SPACA1_ENST00000462690.1_Intron	NM_030960.2	NP_112222.1	Q9HBV2	SACA1_HUMAN	sperm acrosome associated 1	227						integral to membrane		p.V227F(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	20		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.11)		GACCATAGGAGTCATTATCTG	0.368000													40	78					2.87052e-16	4.88968e-16	0.812448	1	0
FBXW4	6468	broad.mit.edu	37	10	103384540	103384540	+	Silent	SNP	G	G	A	rs148535514		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:103384540G>A	ENST00000331272.7	-	6	1416	c.798C>T	c.(796-798)tgC>tgT	p.C266C	FBXW4_ENST00000470093.1_5'UTR	NM_022039.3	NP_071322.1	P57775	FBXW4_HUMAN	F-box and WD repeat domain containing 4	266					ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway	ubiquitin ligase complex		p.C266C(1)		breast(3)|endometrium(2)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	15		Colorectal(252;0.123)		Epithelial(162;4.35e-08)|all cancers(201;1.92e-06)		AGAAGTGCCCGCAACAAGCCG	0.517000													6	24					0	0	0.307466	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22864307	22864307	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:22864307G>T	ENST00000283645.4	+	16	2395	c.2265G>T	c.(2263-2265)gtG>gtT	p.V755V	TUBGCP5_ENST00000453949.2_Silent_p.V755V	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	755					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding	p.V755V(1)		breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		GGCAGAATGTGTCTTTTCTTA	0.353000													7	38					0.000157383	0.000181747	0.278610	1	0
BMP10	27302	broad.mit.edu	37	2	69093072	69093072	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:69093072G>A	ENST00000295379.1	-	2	1124	c.966C>T	c.(964-966)taC>taT	p.Y322Y		NM_014482.1	NP_055297.1	O95393	BMP10_HUMAN	bone morphogenetic protein 10	322					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding	p.Y322Y(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(15)|ovary(2)	27						TCCTCTTACAGTAGTTTCCTT	0.512000													15	30					0	0	0.479597	0	0
ZNF569	148266	broad.mit.edu	37	19	37904566	37904566	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:37904566C>A	ENST00000316950.6	-	6	1551	c.994G>T	c.(994-996)Ggt>Tgt	p.G332C	ZNF569_ENST00000392150.2_Missense_Mutation_p.G173C|ZNF569_ENST00000392149.2_Missense_Mutation_p.G332C	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	332					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G332C(1)		breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAGGCTTTACCACATTCATTA	0.398000													86	152					2.18481e-45	4.29679e-45	0.870114	1	0
SNTG1	54212	broad.mit.edu	37	8	51442811	51442811	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:51442811A>T	ENST00000522124.1	+	10	1202	c.541A>T	c.(541-543)Aac>Tac	p.N181Y	SNTG1_ENST00000517473.1_Missense_Mutation_p.N181Y|SNTG1_ENST00000276467.5_Missense_Mutation_p.N181Y|SNTG1_ENST00000518864.1_Missense_Mutation_p.N181Y	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	181					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding	p.N181Y(2)		NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CTACCATCCCAACAATACAGT	0.428000													6	31					0	0	0.217242	0	0
IQGAP2	10788	broad.mit.edu	37	5	75902092	75902092	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:75902092G>T	ENST00000274364.6	+	12	1618	c.1321G>T	c.(1321-1323)Gat>Tat	p.D441Y	IQGAP2_ENST00000379730.3_5'UTR	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	441					small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity	p.D441Y(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GAATTGTATTGATATGGTTAA	0.358000													10	25					2.80697e-09	3.94313e-09	0.387290	1	0
ZNF638	27332	broad.mit.edu	37	2	71632734	71632734	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:71632734G>T	ENST00000409544.1	+	18	3592	c.2962G>T	c.(2962-2964)Gct>Tct	p.A988S	ZNF638_ENST00000264447.4_Missense_Mutation_p.A988S|ZNF638_ENST00000355812.3_Missense_Mutation_p.A988S	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	988					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding	p.A988S(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TTTTTAGGAAGCTATATTTAT	0.259000													16	36					2.94398e-08	3.9233e-08	0.557998	1	0
CHRND	1144	broad.mit.edu	37	2	233391331	233391331	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:233391331G>T	ENST00000258385.3	+	2	177	c.145G>T	c.(145-147)Gag>Tag	p.E49*	CHRND_ENST00000536614.1_Nonsense_Mutation_p.E49*|CHRND_ENST00000457943.2_5'UTR|CHRND_ENST00000543200.1_Nonsense_Mutation_p.E49*	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	49					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity	p.E49*(1)		breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		GGCACACAAAGAGGAGAGTGT	0.642000													18	69					1.00905e-13	1.61298e-13	0.575678	1	0
WDR5	11091	broad.mit.edu	37	9	137017125	137017125	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:137017125C>T	ENST00000358625.3	+	9	776	c.605C>T	c.(604-606)tCa>tTa	p.S202L	WDR5_ENST00000425041.1_Missense_Mutation_p.S202L	NM_017588.2	NP_060058.1	P61964	WDR5_HUMAN	WD repeat domain 5	202					histone H3 acetylation|histone H3-K4 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|MLL1 complex|Set1C/COMPASS complex	protein binding	p.S202L(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(5)	9		Myeloproliferative disorder(178;0.0255)|Medulloblastoma(224;0.123)		Epithelial(140;6.61e-13)|all cancers(34;5.66e-12)|OV - Ovarian serous cystadenocarcinoma(145;3.93e-08)|GBM - Glioblastoma multiforme(294;0.00326)|READ - Rectum adenocarcinoma(205;0.154)		GACACCGCCTCAGGCCAGTGC	0.562000													5	140					0	0	0.184627	0	0
SEMA6B	10501	broad.mit.edu	37	19	4558098	4558098	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:4558098G>A	ENST00000586582.1	-	3	495	c.185C>T	c.(184-186)gCt>gTt	p.A62V	SEMA6B_ENST00000301293.3_Missense_Mutation_p.A62V|SEMA6B_ENST00000586965.1_Missense_Mutation_p.A62V	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	62	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity	p.A62V(1)		breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGGTCGTCAGCACCTTCTGC	0.627000													4	5					0	0	0.184627	0	0
CXCL12	6387	broad.mit.edu	37	10	44873734	44873734	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:44873734G>T	ENST00000593376.1	+	1	48	c.48G>T	c.(46-48)gaG>gaT	p.E16D	CXCL12_ENST00000395793.3_Intron|CXCL12_ENST00000374429.2_Intron|CXCL12_ENST00000343575.6_3'UTR|CXCL12_ENST00000374426.2_Intron|CXCL12_ENST00000395795.4_Intron|CXCL12_ENST00000395794.2_Intron																							TAAAAAATGAGAATGAGAATG	0.393000													8	11					5.18039e-06	6.30783e-06	0.278610	1	0
NFAM1	150372	broad.mit.edu	37	22	42805469	42805469	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr22:42805469A>T	ENST00000329021.5	-	3	573	c.536T>A	c.(535-537)gTg>gAg	p.V179E		NM_145912.5	NP_666017.1	Q8NET5	NFAM1_HUMAN	NFAT activating protein with ITAM motif 1	179					B cell differentiation|inflammatory response|intracellular signal transduction|positive regulation of B cell receptor signaling pathway|positive regulation of cytokine production|positive regulation of sequence-specific DNA binding transcription factor activity	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity	p.V179E(1)		large_intestine(1)|lung(3)	4						GGCCGTGCCCACTACACTCAG	0.657000													6	65					0	0	0.248553	0	0
EPHA6	285220	broad.mit.edu	37	3	97251300	97251300	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:97251300C>A	ENST00000389672.5	+	11	2337	c.2299C>A	c.(2299-2301)Caa>Aaa	p.Q767K	EPHA6_ENST00000514100.1_Missense_Mutation_p.Q159K|EPHA6_ENST00000502694.1_Missense_Mutation_p.Q159K|EPHA6_ENST00000442602.2_Missense_Mutation_p.Q133K	NM_001080448.2	NP_001073917.2	Q9UF33	EPHA6_HUMAN	EPH receptor A6	672	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity	p.Q673K(1)|p.Q767K(1)|p.Q159K(1)		NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						CATGGATCGGCAAAGAAGAGA	0.443000													20	40					8.34094e-07	1.04908e-06	0.575678	1	0
PPP1R3F	89801	broad.mit.edu	37	X	49142326	49142326	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:49142326G>A	ENST00000055335.6	+	4	1190	c.1174G>A	c.(1174-1176)Gca>Aca	p.A392T	PPP1R3F_ENST00000438316.1_Missense_Mutation_p.A63T|PPP1R3F_ENST00000376188.1_Missense_Mutation_p.A46T|PPP1R3F_ENST00000495799.1_Missense_Mutation_p.A46T|PPP1R3F_ENST00000466508.1_Missense_Mutation_p.A46T	NM_033215.4	NP_149992.3	Q6ZSY5	PPR3F_HUMAN	protein phosphatase 1, regulatory subunit 3F	392						integral to membrane		p.A392T(1)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|skin(4)	27	Ovarian(276;0.236)					TGGCAACCCCGCAGAAGAAGG	0.592000													7	8					0	0	0.361761	0	0
SLC36A1	206358	broad.mit.edu	37	5	150846759	150846759	+	Splice_Site	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:150846759G>C	ENST00000243389.3	+	6	642		c.e6-1		SLC36A1_ENST00000521925.1_Splice_Site|SLC36A1_ENST00000429484.2_Splice_Site|SLC36A1_ENST00000520701.1_Splice_Site	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1						cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity	p.?(1)		endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CCCACCTCCAGACGTGTTGTG	0.423000													31	80					0	0	0.779181	0	0
DACH1	1602	broad.mit.edu	37	13	72146989	72146989	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:72146989C>G	ENST00000305425.4	-	4	1710	c.1288G>C	c.(1288-1290)Gag>Cag	p.E430Q	DACH1_ENST00000313174.7_Intron|DACH1_ENST00000354591.4_Intron|DACH1_ENST00000359684.2_Missense_Mutation_p.E482Q	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	480					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding	p.E430Q(1)		NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		ACTGATGTCTCAACTCTGGAT	0.408000													3	65					0	0	0.115264	0	0
OR11H6	122748	broad.mit.edu	37	14	20692663	20692663	+	Silent	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:20692663G>C	ENST00000315519.2	+	1	873	c.795G>C	c.(793-795)gtG>gtC	p.V265V		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	265					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V265V(1)		cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		ACCTAATGGTGGTGTCTCTAT	0.478000													30	44					0	0	0.729181	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133828	91133828	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:91133828G>T	ENST00000373094.1	+	2	3434	c.2589G>T	c.(2587-2589)caG>caT	p.Q863H	PCDH11X_ENST00000361724.1_Missense_Mutation_p.Q863H|PCDH11X_ENST00000373097.1_Missense_Mutation_p.Q863H|PCDH11X_ENST00000395337.2_Missense_Mutation_p.Q863H|PCDH11X_ENST00000373088.1_Missense_Mutation_p.Q863H|PCDH11X_ENST00000361655.2_Missense_Mutation_p.Q863H|PCDH11X_ENST00000298274.8_Missense_Mutation_p.Q863H|PCDH11X_ENST00000504220.1_Missense_Mutation_p.Q863H|PCDH11X_ENST00000406881.1_Missense_Mutation_p.Q863H	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	863					homophilic cell adhesion	integral to plasma membrane	calcium ion binding	p.Q863H(3)		NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						AAAACAGGCAGATGATAATGA	0.413000													17	9					2.48551e-13	3.90579e-13	0.520397	1	0
C15orf43	145645	broad.mit.edu	37	15	45253761	45253761	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:45253761C>A	ENST00000340827.3	+	4	344	c.327C>A	c.(325-327)gaC>gaA	p.D109E		NM_152448.2	NP_689661.1	Q8NHR7	CO043_HUMAN	chromosome 15 open reading frame 43	109								p.D109E(1)		NS(1)|breast(2)|large_intestine(1)|lung(2)|skin(2)	8		all_cancers(109;3.68e-08)|all_epithelial(112;1.05e-06)|Lung NSC(122;1.42e-05)|all_lung(180;0.000112)|Melanoma(134;0.0192)		all cancers(107;7.64e-17)|GBM - Glioblastoma multiforme(94;2.03e-06)		GGGAACAAGACCAACATTTTC	0.284000													12	56					0.000219431	0.000252055	0.457914	1	0
FOXD3	27022	broad.mit.edu	37	1	63789229	63789229	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:63789229T>A	ENST00000371116.2	+	1	500	c.500T>A	c.(499-501)aTc>aAc	p.I167N	RP4-792G4.2_ENST00000431294.1_RNA|RP4-792G4.2_ENST00000427268.1_RNA	NM_012183.2	NP_036315.1	Q9UJU5	FOXD3_HUMAN	forkhead box D3	167					axon extension involved in axon guidance|branching involved in ureteric bud morphogenesis|cartilage development|embryonic placenta development|enteric nervous system development|iridophore differentiation|kidney development|lateral line nerve glial cell development|melanocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development|trophectodermal cell differentiation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.I167N(1)		breast(1)|cervix(1)|lung(2)|upper_aerodigestive_tract(1)	5						CTGAGCGGCATCTGCGAGTTC	0.582000													4	75					0	0	0.150653	0	0
CRTC2	200186	broad.mit.edu	37	1	153920685	153920685	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:153920685T>A	ENST00000368633.1	-	14	2109	c.1982A>T	c.(1981-1983)gAg>gTg	p.E661V	CRTC2_ENST00000368630.3_Missense_Mutation_p.E341V	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	661					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding	p.E661V(1)		NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCCCAGTGGCTCCATGCGCAG	0.597000													31	74					0	0	0.740014	0	0
GBA3	57733	broad.mit.edu	37	4	22737808	22737808	+	RNA	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:22737808C>A	ENST00000511446.1	+	0	266				GBA3_ENST00000508166.1_RNA|GBA3_ENST00000503442.1_RNA	NM_001277225.1	NP_001264154.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity	p.T88K(1)		breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CCTGATGGGACGACAGGTTTC	0.413000													28	90					1.39806e-14	2.30875e-14	0.729181	1	0
NCAM2	4685	broad.mit.edu	37	21	22804541	22804541	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:22804541G>T	ENST00000400546.1	+	12	1843	c.1594G>T	c.(1594-1596)Gtg>Ttg	p.V532L	NCAM2_ENST00000284894.7_Missense_Mutation_p.V390L	NM_004540.3	NP_004531.2	O15394	NCAM2_HUMAN	neural cell adhesion molecule 2	532	Fibronectin type-III 1.				neuron cell-cell adhesion	integral to membrane|plasma membrane		p.V532L(1)		breast(4)|cervix(2)|endometrium(8)|kidney(6)|large_intestine(22)|liver(4)|lung(49)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	108		Lung NSC(9;0.195)		all cancers(11;0.00102)|OV - Ovarian serous cystadenocarcinoma(11;0.00121)|Epithelial(23;0.00147)|Colorectal(24;0.174)		TCACTATCAGGTGGATGTCAA	0.443000													16	33					1.99824e-07	2.59371e-07	0.520397	1	0
SLC2A10	81031	broad.mit.edu	37	20	45362406	45362406	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr20:45362406G>T	ENST00000359271.2	+	5	1809	c.1559G>T	c.(1558-1560)aGc>aTc	p.S520I		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	520						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity	p.S520I(1)		central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				TTCACCCTGAGCTTTGGCCAC	0.617000													12	52					7.03913e-09	9.69935e-09	0.411799	1	0
SMC5	23137	broad.mit.edu	37	9	72965093	72965093	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:72965093G>A	ENST00000361138.5	+	23	3011	c.2953G>A	c.(2953-2955)Gaa>Aaa	p.E985K	SMC5_ENST00000471372.1_3'UTR	NM_015110.3	NP_055925.2	Q8IY18	SMC5_HUMAN	structural maintenance of chromosomes 5	985					DNA recombination|DNA repair	chromosome|nucleus	ATP binding	p.E985K(1)		breast(1)|central_nervous_system(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(4)	35						TCAACTGCATGAATTAACTCC	0.328000													9	72					0	0	0.307466	0	0
DPP10	57628	broad.mit.edu	37	2	116485391	116485391	+	Splice_Site	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:116485391G>C	ENST00000410059.1	+	8	1056		c.e8-1		DPP10_ENST00000488208.1_Splice_Site|DPP10_ENST00000393147.2_Splice_Site|DPP10_ENST00000409163.1_Splice_Site|DPP10_ENST00000310323.8_Splice_Site	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)						proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity	p.?(4)		breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						TCCTGATCCAGATTTATATTT	0.299000													12	24					0	0	0.457914	0	0
IGKV1-5	28299	broad.mit.edu	37	2	89247003	89247003	+	RNA	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:89247003G>C	ENST00000496168.1	-	0	347																											CTGATACCAGGCCAACCAGCT	0.527000													37	80					0	0	0.804634	0	0
NUP214	8021	broad.mit.edu	37	9	134034830	134034830	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:134034830G>T	ENST00000359428.5	+	18	2641	c.2497G>T	c.(2497-2499)Gac>Tac	p.D833Y	RP11-544A12.4_ENST00000589540.1_RNA|RP11-544A12.4_ENST00000589667.1_RNA|RP11-544A12.4_ENST00000588378.1_RNA|RP11-544A12.4_ENST00000590461.1_RNA|NUP214_ENST00000411637.2_Missense_Mutation_p.D823Y|NUP214_ENST00000451030.1_Missense_Mutation_p.D834Y|RP11-544A12.4_ENST00000587264.1_RNA|RP11-544A12.4_ENST00000586290.1_RNA|RP11-544A12.4_ENST00000417798.2_RNA|RP11-544A12.4_ENST00000587408.1_RNA|RP11-544A12.4_ENST00000415391.2_RNA|RP11-544A12.4_ENST00000589128.1_RNA			P35658	NU214_HUMAN	nucleoporin 214kDa	833	11 X 5 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mRNA metabolic process|protein export from nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore|nucleoplasm	protein binding	p.D833Y(1)		NS(1)|breast(9)|central_nervous_system(3)|endometrium(13)|kidney(2)|large_intestine(9)|liver(2)|lung(29)|ovary(2)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	86	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;3.42e-05)|Epithelial(140;0.000256)		TGATGTTCTAGACTTGGAGTG	0.348000			T	"""DEK, SET, ABL1"""	"""AML, T-ALL"""								17	20					2.35188e-11	3.56629e-11	0.539581	1	0
MAPKAPK5	8550	broad.mit.edu	37	12	112323739	112323739	+	Nonsense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:112323739G>T	ENST00000550735.2	+	10	1624	c.868G>T	c.(868-870)Gag>Tag	p.E290*	MAPKAPK5_ENST00000551404.2_Nonsense_Mutation_p.E290*	NM_003668.2|NM_139078.1	NP_003659.2|NP_620777.1	Q8IW41	MAPK5_HUMAN	mitogen-activated protein kinase-activated protein kinase 5	290	Protein kinase.				signal transduction	cytoplasm|nucleus	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity	p.E290*(2)		endometrium(1)|lung(11)|ovary(1)	13						GGTCAAACCGGAGGAGAGACT	0.557000													13	9					2.27111e-07	2.91871e-07	0.411799	1	0
H6PD	9563	broad.mit.edu	37	1	9324728	9324728	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:9324728C>G	ENST00000377403.2	+	5	2478	c.2176C>G	c.(2176-2178)Cac>Gac	p.H726D	H6PD_ENST00000602477.1_Missense_Mutation_p.H737D	NM_004285.3	NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	726	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding	p.H726D(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	CTCCCAGCCACACCGCCGCAT	0.647000													6	10					0	0	0.479597	0	0
CX3CR1	1524	broad.mit.edu	37	3	39323174	39323174	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:39323174G>T	ENST00000358309.3	-	1	52	c.13C>A	c.(13-15)Ctg>Atg	p.L5M		NM_001171174.1	NP_001164645.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	0					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity	p.L5M(1)		endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		aacgcctccaggggttctctc	0.552000													4	14					0.217242	0.219269	0.217242	1	0
ZNF345	25850	broad.mit.edu	37	19	37367788	37367788	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:37367788A>G	ENST00000529555.1	+	2	844	c.56A>G	c.(55-57)gAa>gGa	p.E19G	ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000526123.1_Intron|ZNF345_ENST00000589046.1_Missense_Mutation_p.E19G|ZNF345_ENST00000420450.1_Missense_Mutation_p.E19G			Q14585	ZN345_HUMAN	zinc finger protein 345	19					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription from RNA polymerase II promoter|transcription from RNA polymerase III promoter	nucleus	DNA binding|zinc ion binding	p.E19G(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|ovary(2)|prostate(1)	24	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			GGTGATTGGGAATGTAAAAAC	0.368000													34	82					0	0	0.769981	0	0
ZNF211	10520	broad.mit.edu	37	19	58152597	58152597	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:58152597A>T	ENST00000544273.1	+	5	1106	c.779A>T	c.(778-780)cAg>cTg	p.Q260L	ZNF211_ENST00000254182.7_Missense_Mutation_p.Q239L|ZNF211_ENST00000240731.4_Missense_Mutation_p.Q261L|ZNF211_ENST00000347302.3_Missense_Mutation_p.Q248L|ZNF211_ENST00000299871.5_Missense_Mutation_p.Q313L|ZNF211_ENST00000420680.1_Missense_Mutation_p.Q252L|ZNF211_ENST00000391703.3_Missense_Mutation_p.Q187L|ZNF211_ENST00000541801.1_Missense_Mutation_p.Q239L			Q13398	ZN211_HUMAN	zinc finger protein 211	248						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.Q261L(1)		breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTTCAGGACCAGAGAATCCTC	0.443000													67	47					0	0	0.870114	0	0
OR2G6	391211	broad.mit.edu	37	1	248685394	248685394	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:248685394G>T	ENST00000343414.4	+	1	479	c.447G>T	c.(445-447)tgG>tgT	p.W149C		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.W149C(1)		NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GTGGAGCATGGCTCAGCGGCC	0.582000													7	30					0.00307968	0.00333119	0.278610	1	0
SLC16A3	9123	broad.mit.edu	37	17	80194624	80194624	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:80194624C>A	ENST00000581287.1	+	2	2565	c.243C>A	c.(241-243)tgC>tgA	p.C81*	SLC16A3_ENST00000584781.1_3'UTR|SLC16A3_ENST00000392341.1_Nonsense_Mutation_p.C81*|SLC16A3_ENST00000392339.1_Nonsense_Mutation_p.C81*|SLC16A3_ENST00000582743.1_Nonsense_Mutation_p.C81*	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	81					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity	p.C81*(1)		endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	GCAGTGTGTGCGTGAACCGCT	0.667000											OREG0024821	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	46					7.87624e-14	1.26527e-13	0.639603	1	0
DNAH3	55567	broad.mit.edu	37	16	21011740	21011740	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:21011740G>C	ENST00000261383.3	-	43	6226	c.6227C>G	c.(6226-6228)aCa>aGa	p.T2076R	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2076	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.T2076R(2)		NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		GCCAGTGCCTGTGGGACCCAC	0.498000													12	27					0	0	0.411799	0	0
OR4C46	119749	broad.mit.edu	37	11	51516184	51516184	+	Silent	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:51516184T>C	ENST00000328188.1	+	1	903	c.903T>C	c.(901-903)agT>agC	p.S301S		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	301					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S301S(1)		endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						AATTGTGTAGTAGAAAGGACA	0.358000													16	22					0	0	0.520397	0	0
CUBN	8029	broad.mit.edu	37	10	16982167	16982167	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:16982167C>A	ENST00000377833.4	-	37	5477	c.5412G>T	c.(5410-5412)acG>acT	p.T1804T		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1804	CUB 12.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity	p.T1804T(1)		breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCAAGTGACCCGTGGCATTTC	0.448000													52	199					9.86064e-34	1.91032e-33	0.870114	1	0
PRSS1	5644	broad.mit.edu	37	7	142458452	142458452	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:142458452C>A	ENST00000486171.1	+	2	104	c.87C>A	c.(85-87)aaC>aaA	p.N29K	PRSS1_ENST00000311737.7_Missense_Mutation_p.N29K			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	29	Peptidase S1.		N -> I (in PCTT).|N -> T (in PCTT).		digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity	p.N29K(1)		central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GGGGCTACAACTGTGAGGAGA	0.542000													7	128					8.12818e-05	9.52201e-05	0.248553	1	0
ZNF761	388561	broad.mit.edu	37	19	53958705	53958705	+	RNA	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:53958705G>A	ENST00000454407.1	+	0	1397							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R261K(1)		endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		ATACTTGAAAGACATAGGATA	0.383000													14	112					0	0	0.479597	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121651939	121651939	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:121651939G>T	ENST00000393386.2	+	12	3250	c.2839G>T	c.(2839-2841)Gca>Tca	p.A947S	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	947					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity	p.A947S(2)		NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						TTACAGTTCTGCAATACCTGT	0.448000													28	79					3.65163e-15	6.07668e-15	0.706142	1	0
OLFML2B	25903	broad.mit.edu	37	1	161954010	161954010	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:161954010C>A	ENST00000294794.3	-	8	2131	c.1708G>T	c.(1708-1710)Gta>Tta	p.V570L	OLFML2B_ENST00000367938.1_Missense_Mutation_p.V53L|OLFML2B_ENST00000367940.2_Missense_Mutation_p.V571L	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	570	Olfactomedin-like.							p.V570L(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			CCATTGTATACCACGTGGCCT	0.577000													17	51					2.37509e-13	3.76879e-13	0.592651	1	0
RYR2	6262	broad.mit.edu	37	1	237608780	237608780	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:237608780G>C	ENST00000366574.2	+	14	1567	c.1250G>C	c.(1249-1251)cGa>cCa	p.R417P	RYR2_ENST00000360064.6_Missense_Mutation_p.R415P|RYR2_ENST00000542537.1_Missense_Mutation_p.R401P	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	417					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.R415Q(1)|p.R415P(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CGCACAGCCCGAGTTATCCGG	0.383000													13	49					0	0	0.411799	0	0
PLB1	151056	broad.mit.edu	37	2	28841261	28841261	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:28841261C>A	ENST00000422425.2	+	45	3321	c.3277C>A	c.(3277-3279)Ctg>Atg	p.L1093M	PLB1_ENST00000541605.1_Missense_Mutation_p.L69M|PLB1_ENST00000327757.5_Missense_Mutation_p.L1104M	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1104	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity	p.L1104M(1)|p.L1093M(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GGGTGACTCTCTGACTGTGAG	0.597000													15	38					2.48551e-13	3.90579e-13	0.520397	1	0
C17orf59	54785	broad.mit.edu	37	17	8092736	8092736	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:8092736G>A	ENST00000389017.4	-	1	828	c.723C>T	c.(721-723)ccC>ccT	p.P241P		NM_017622.2	NP_060092.2	Q96GS4	CQ059_HUMAN	chromosome 17 open reading frame 59	241	Pro-rich.							p.P241P(1)|p.P107P(1)		large_intestine(2)|lung(3)|urinary_tract(1)	6						GCGCTGGGCAGGGCCGCGCAG	0.701000													9	2					0	0	0.307466	0	0
LDB3	11155	broad.mit.edu	37	10	88441349	88441349	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:88441349G>T	ENST00000429277.2	+	5	623	c.478G>T	c.(478-480)Gac>Tac	p.D160Y	LDB3_ENST00000372056.4_Missense_Mutation_p.D160Y|LDB3_ENST00000263066.6_Intron|LDB3_ENST00000310944.6_Missense_Mutation_p.D160Y|LDB3_ENST00000361373.4_Missense_Mutation_p.D160Y|LDB3_ENST00000352360.5_Intron|LDB3_ENST00000372066.3_Intron|LDB3_ENST00000542786.1_Missense_Mutation_p.D160Y|LDB3_ENST00000458213.2_Intron	NM_001171610.1	NP_001165081.1	O75112	LDB3_HUMAN	LIM domain binding 3	160						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding	p.D160Y(3)		breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						CGAGGCCTCTGACCCTGGCCC	0.736000													10	31					1.58986e-06	1.98046e-06	0.361761	1	0
ACO1	48	broad.mit.edu	37	9	32424649	32424649	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:32424649T>A	ENST00000379923.1	+	11	1380	c.1174T>A	c.(1174-1176)Tgc>Agc	p.C392S	ACO1_ENST00000309951.5_Missense_Mutation_p.C392S|ACO1_ENST00000541043.1_Missense_Mutation_p.C293S	NM_001278352.1	NP_001265281.1	P21399	ACOC_HUMAN	aconitase 1, soluble	392					citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding	p.C392S(2)		breast(1)|endometrium(7)|kidney(5)|large_intestine(6)|lung(6)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	30			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		CTTTGAGAGCTGCCTTGGAGC	0.502000													23	64					0	0	0.654019	0	0
F2RL2	2151	broad.mit.edu	37	5	75913420	75913420	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:75913420T>A	ENST00000296641.4	-	2	1315	c.1112A>T	c.(1111-1113)tAc>tTc	p.Y371F	F2RL2_ENST00000504899.1_Missense_Mutation_p.Y349F|IQGAP2_ENST00000502745.1_Intron|IQGAP2_ENST00000274364.6_Intron|IQGAP2_ENST00000379730.3_Intron|IQGAP2_ENST00000396234.3_Intron	NM_004101.3	NP_004092.1	O00254	PAR3_HUMAN	coagulation factor II (thrombin) receptor-like 2	371					platelet activation	extracellular region|integral to plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|thrombin receptor activity	p.Y371F(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(3)	32		all_lung(232;0.000462)|Lung NSC(167;0.00124)|Prostate(461;0.00955)|Ovarian(174;0.0129)		all cancers(79;4.43e-43)		TTTTGTAAGGTAAGCAGTGGA	0.368000													7	29					0	0	0.278610	0	0
MYO16	23026	broad.mit.edu	37	13	109613918	109613918	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:109613918C>A	ENST00000356711.2	+	18	2129	c.2003C>A	c.(2002-2004)gCa>gAa	p.A668E	MYO16_ENST00000251041.5_Missense_Mutation_p.A668E|MYO16_ENST00000357550.2_Missense_Mutation_p.A668E|MYO16_ENST00000457511.2_Missense_Mutation_p.A180E	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	668	Myosin head-like 1.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity	p.A668E(1)		NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATTCTAGCAGCAATATTGCAC	0.428000													4	108					0.150653	0.153011	0.150653	1	0
TNFSF4	7292	broad.mit.edu	37	1	173176276	173176276	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:173176276C>A	ENST00000281834.3	-	1	176	c.40G>T	c.(40-42)Gca>Tca	p.A14S		NM_003326.3	NP_003317.1	P23510	TNFL4_HUMAN	tumor necrosis factor (ligand) superfamily, member 4	14					acute inflammatory response|cellular response to lipopolysaccharide|cellular response to prostaglandin E stimulus|chemokine (C-C motif) ligand 11 production|defense response to nematode|interleukin-4-dependent isotype switching to IgE isotypes|memory T cell activation|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of regulatory T cell differentiation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of T-helper 1 cell differentiation|negative regulation of transcription, DNA-dependent|positive regulation of alpha-beta T cell proliferation|positive regulation of B cell activation|positive regulation of immunoglobulin mediated immune response|positive regulation of immunoglobulin secretion|positive regulation of inflammatory response|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-13 production|positive regulation of interleukin-4 production|positive regulation of interleukin-6 production|positive regulation of memory T cell differentiation|positive regulation of T cell cytokine production|positive regulation of T-helper 2 cell differentiation|positive regulation of type 2 immune response|response to virus|signal transduction|T-helper 2 cell activation	cell surface|extracellular space|integral to plasma membrane	cytokine activity	p.A14S(1)		breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	12						GGCCTGGCTGCATTTCCCACA	0.507000													16	43					2.23348e-06	2.76101e-06	0.500413	1	0
ZNF25	219749	broad.mit.edu	37	10	38246347	38246347	+	Splice_Site	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:38246347C>A	ENST00000302609.7	-	3	355		c.e3+1		ZNF25_ENST00000374633.1_Splice_Site	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.?(1)		breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				GTTTTCCTCACCCACTGAGAC	0.423000													22	68					1.66031e-10	2.416e-10	0.667858	1	0
MAGEC1	9947	broad.mit.edu	37	X	140992863	140992863	+	Splice_Site	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:140992863G>T	ENST00000285879.4	+	3	290		c.e3+1		MAGEC1_ENST00000406005.2_Splice_Site	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1								protein binding	p.?(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GCCATCATGGGTGAGTTTCTC	0.547000										HNSCC(15;0.026)			18	18					5.03518e-11	7.51226e-11	0.557998	1	0
KIF2B	84643	broad.mit.edu	37	17	51900813	51900813	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:51900813G>C	ENST00000268919.4	+	1	575	c.419G>C	c.(418-420)tGt>tCt	p.C140S		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	140					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity	p.C140S(1)		NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						AGCAAACCTTGTCTGATGAAG	0.572000													23	56					0	0	0.639603	0	0
ABCG8	64241	broad.mit.edu	37	2	44078951	44078951	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:44078951G>T	ENST00000272286.2	+	4	641	c.551G>T	c.(550-552)cGt>cTt	p.R184L		NM_022437.2	NP_071882.1	Q9H221	ABCG8_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 8	184	ABC transporter.		R -> H (in STSL).		cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity	p.R184H(1)|p.R184L(1)		NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(21)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CAGGCCCAGCGTGACAAAAGG	0.622000													24	62					3.28513e-13	5.13746e-13	0.667858	1	0
AMER2	219287	broad.mit.edu	37	13	25744194	25744194	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr13:25744194C>A	ENST00000357816.2	-	3	1682	c.1207G>T	c.(1207-1209)Gag>Tag	p.E403*	AMER2_ENST00000381853.3_Nonsense_Mutation_p.E403*|AMER2_ENST00000515384.1_Nonsense_Mutation_p.E522*					APC membrane recruitment protein 2									p.E522*(1)|p.E403*(1)									CAGTAGCCCTCGTCGCTGTTG	0.662000													19	25					2.39556e-15	4.01737e-15	0.639603	1	0
OR2T3	343173	broad.mit.edu	37	1	248637201	248637201	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:248637201T>A	ENST00000359594.2	+	1	575	c.550T>A	c.(550-552)Tgt>Agt	p.C184S		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C184S(1)		breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAGTTTTTTCTGTGAGACTCC	0.517000													17	63					0	0	0.575678	0	0
FAM101B	359845	broad.mit.edu	37	17	293213	293213	+	Silent	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:293213C>G	ENST00000329099.4	-	2	176	c.177G>C	c.(175-177)gcG>gcC	p.A59A		NM_182705.2	NP_874364.1	Q8N5W9	F101B_HUMAN	family with sequence similarity 101, member B	129								p.A59A(1)		breast(1)|endometrium(3)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)|urinary_tract(1)	13		Myeloproliferative disorder(207;0.204)		UCEC - Uterine corpus endometrioid carcinoma (25;0.0216)		AGGAGGCCACCGCCAGGCCCA	0.662000													24	26					0	0	0.667858	0	0
IL9R	3581	broad.mit.edu	37	X	155233519	155233519	+	Splice_Site	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:155233519C>A	ENST00000424344.3	+	5	736	c.370_splice	c.e5+1	p.H123_splice	IL9R_ENST00000540897.1_Splice_Site_p.T179_splice|IL9R_ENST00000244174.5_Splice_Site_p.H144_splice|IL9R_ENST00000369423.2_Splice_Site_p.T189_splice			Q01113	IL9R_HUMAN	interleukin 9 receptor	144					cell proliferation	extracellular space|integral to plasma membrane	interleukin-9 receptor activity	p.H144Q(1)		NS(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(12)|upper_aerodigestive_tract(1)	23	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCCGGAGACACGGTGAGCAGC	0.622000													5	24					0.00116845	0.00129406	0.217242	1	0
CSNK1D	1453	broad.mit.edu	37	17	80213371	80213371	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:80213371C>A	ENST00000314028.6	-	3	619	c.270G>T	c.(268-270)gaG>gaT	p.E90D	CSNK1D_ENST00000578904.1_5'UTR|CSNK1D_ENST00000392334.2_Missense_Mutation_p.E90D|CSNK1D_ENST00000398519.5_Missense_Mutation_p.E90D	NM_001893.4	NP_001884.2	P48730	KC1D_HUMAN	casein kinase 1, delta	90	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity	p.E90D(3)		breast(2)|large_intestine(2)|lung(7)	11	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			TGAAGAGGTCCTCCAGGCTTG	0.547000													24	50					6.32553e-13	9.84477e-13	0.681144	1	0
TRBV10-1	28585	broad.mit.edu	37	7	142231754	142231754	+	RNA	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:142231754G>A	ENST00000390364.3	-	0	230																											AGGTCTTGTCGATACCAGAAC	0.488000													4	153					0	0	0.184627	0	0
BAGE2	85319	broad.mit.edu	37	21	11098762	11098762	+	RNA	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:11098762C>A	ENST00000470054.1	-	0	163									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		cccactcctaccgctcaggcc	0.627000													10	42					4.68919e-08	6.17299e-08	0.361761	1	0
TCF4	6925	broad.mit.edu	37	18	52896228	52896228	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr18:52896228C>A	ENST00000354452.3	-	18	2340	c.1729G>T	c.(1729-1731)Gag>Tag	p.E577*	TCF4_ENST00000561992.1_Nonsense_Mutation_p.E443*|TCF4_ENST00000564403.2_Nonsense_Mutation_p.E583*|TCF4_ENST00000564999.1_Nonsense_Mutation_p.E573*|TCF4_ENST00000570287.2_Nonsense_Mutation_p.E413*|TCF4_ENST00000566279.1_Nonsense_Mutation_p.E517*|TCF4_ENST00000543082.1_Nonsense_Mutation_p.E531*|TCF4_ENST00000537856.3_Nonsense_Mutation_p.E443*|TCF4_ENST00000570177.2_Nonsense_Mutation_p.E443*|TCF4_ENST00000540999.1_Nonsense_Mutation_p.E549*|TCF4_ENST00000398339.1_Nonsense_Mutation_p.E679*|TCF4_ENST00000564228.1_Nonsense_Mutation_p.E502*|TCF4_ENST00000561831.3_Nonsense_Mutation_p.E413*|TCF4_ENST00000457482.3_Nonsense_Mutation_p.E417*|TCF4_ENST00000356073.4_Nonsense_Mutation_p.E573*|TCF4_ENST00000567880.1_Nonsense_Mutation_p.E513*|TCF4_ENST00000537578.1_Nonsense_Mutation_p.E553*|TCF4_ENST00000565018.2_Nonsense_Mutation_p.E577*|TCF4_ENST00000568740.1_Nonsense_Mutation_p.E548*|TCF4_ENST00000568673.1_Nonsense_Mutation_p.E553*|TCF4_ENST00000566286.1_Nonsense_Mutation_p.E570*|TCF4_ENST00000544241.2_Nonsense_Mutation_p.E506*	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	573	Helix-loop-helix motif.				positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding	p.E679*(1)|p.E573*(1)		breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		CGCAGACGCTCTCGGGCATTG	0.572000													38	40					7.53189e-24	1.42099e-23	0.834066	1	0
DNM1P46	196968	broad.mit.edu	37	15	100332754	100332754	+	RNA	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:100332754C>A	ENST00000341853.1	-	0	1437					NR_003260.1																						TGCATAACAGCTGAGCACCCC	0.612000													4	38					0.00909568	0.00961416	0.150653	1	0
PCDHGA12	26025	broad.mit.edu	37	5	140811375	140811375	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:140811375C>T	ENST00000252085.3	+	1	1191	c.1049C>T	c.(1048-1050)aCc>aTc	p.T350I	PCDHGA11_ENST00000518882.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA8_ENST00000398604.2_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1												p.T350I(2)		breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGTCCTCACCTCTCTCGCC	0.488000													17	40					0	0	0.557998	0	0
COL5A1	1289	broad.mit.edu	37	9	137676916	137676916	+	Missense_Mutation	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:137676916G>C	ENST00000371817.3	+	30	2980	c.2566G>C	c.(2566-2568)Ggt>Cgt	p.G856R		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	856	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding	p.G856R(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGGTGACCCCGGTCCTCTGGG	0.647000													5	25					0	0	0.184627	0	0
RBM42	79171	broad.mit.edu	37	19	36120454	36120454	+	Missense_Mutation	SNP	C	C	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:36120454C>G	ENST00000262633.4	+	2	266	c.161C>G	c.(160-162)cCt>cGt	p.P54R	RBM42_ENST00000586618.1_Missense_Mutation_p.P54R|RBM42_ENST00000588161.1_Missense_Mutation_p.P54R|RBM42_ENST00000592202.1_Missense_Mutation_p.P54R|RBM42_ENST00000360475.4_Missense_Mutation_p.P54R|RBM42_ENST00000589871.1_Missense_Mutation_p.P54R|RBM42_ENST00000589559.1_Missense_Mutation_p.P54R	NM_024321.3	NP_077297.2	Q9BTD8	RBM42_HUMAN	RNA binding motif protein 42	54						cytoplasm|nucleus	nucleotide binding|RNA binding	p.P54R(1)		breast(1)|endometrium(3)|large_intestine(7)|lung(9)|prostate(1)	21	all_lung(56;1.58e-07)|Lung NSC(56;2.43e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCTCCAGTACCTGGAATCCCA	0.577000													36	65					0	0	0.796494	0	0
SPAG6	9576	broad.mit.edu	37	10	22680714	22680714	+	Silent	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:22680714T>A	ENST00000376603.2	+	8	1432	c.1290T>A	c.(1288-1290)gcT>gcA	p.A430A	SPAG6_ENST00000376624.3_Silent_p.A354A|SPAG6_ENST00000376601.1_Silent_p.A115A|SPAG6_ENST00000313311.6_Silent_p.A354A|RP11-301N24.3_ENST00000422675.1_RNA|SPAG6_ENST00000538630.1_Silent_p.A329A			O75602	SPAG6_HUMAN	sperm associated antigen 6	354					cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding	p.A354A(1)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|prostate(1)|skin(2)	27						ATATTAAGGCTGCAGCTGCTT	0.483000													12	29					0	0	0.500413	0	0
TCP11	6954	broad.mit.edu	37	6	35088692	35088692	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:35088692G>T	ENST00000311875.5	-	6	1165	c.748C>A	c.(748-750)Cag>Aag	p.Q250K	TCP11_ENST00000373979.2_Missense_Mutation_p.Q175K|TCP11_ENST00000512012.1_Missense_Mutation_p.Q237K|TCP11_ENST00000244645.3_Missense_Mutation_p.Q175K|TCP11_ENST00000412155.2_Missense_Mutation_p.Q199K|TCP11_ENST00000373974.4_Missense_Mutation_p.Q204K|TCP11_ENST00000418521.2_Missense_Mutation_p.Q174K|TCP11_ENST00000444780.2_Missense_Mutation_p.Q245K			Q8WWU5	TCP11_HUMAN	t-complex 11, testis-specific	237					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane		p.Q250K(1)|p.Q175K(1)		breast(1)|kidney(5)|large_intestine(3)|lung(10)|ovary(3)|prostate(1)|skin(4)	27						ATACTAGGCTGCTTATTGAGG	0.418000													111	280					1.9213e-43	3.76714e-43	0.870114	1	0
THEM5	284486	broad.mit.edu	37	1	151824854	151824854	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:151824854G>T	ENST00000368817.5	-	2	336	c.205C>A	c.(205-207)Ctg>Atg	p.L69M		NM_182578.3	NP_872384.1	Q8N1Q8	THEM5_HUMAN	thioesterase superfamily member 5	69							hydrolase activity	p.L69M(1)		breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)	15	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TCTTGGTACAGGCTCAGCATG	0.502000													31	85					2.61193e-14	4.23786e-14	0.740014	1	0
ZNF417	147687	broad.mit.edu	37	19	58420582	58420582	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:58420582C>A	ENST00000312026.5	-	3	1228	c.1064G>T	c.(1063-1065)gGg>gTg	p.G355V	ZNF417_ENST00000595559.1_Missense_Mutation_p.G354V|ZNF417_ENST00000536263.1_Missense_Mutation_p.G156V|CTD-2583A14.9_ENST00000602124.1_Intron	NM_152475.2	NP_689688.2	Q8TAU3	ZN417_HUMAN	zinc finger protein 417	355					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G355V(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|stomach(3)|upper_aerodigestive_tract(1)	18		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0151)		CCCACATTCCCCACAGTGATA	0.428000													84	89					8.61122e-29	1.65836e-28	0.870114	1	0
SLC19A3	80704	broad.mit.edu	37	2	228566913	228566913	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:228566913C>A	ENST00000258403.3	-	2	193	c.122G>T	c.(121-123)gGa>gTa	p.G41V	SLC19A3_ENST00000409287.1_Missense_Mutation_p.G41V|SLC19A3_ENST00000541617.1_5'UTR	NM_025243.3	NP_079519.1	Q9BZV2	S19A3_HUMAN	solute carrier family 19 (thiamine transporter), member 3	41					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity	p.G41V(1)		breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|skin(3)	30		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	TTTATCTGGTCCAGATAAATA	0.388000													33	75					1.57351e-24	2.99475e-24	0.788014	1	0
KRTAP13-1	140258	broad.mit.edu	37	21	31768427	31768427	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:31768427G>A	ENST00000355459.2	+	1	36	c.23G>A	c.(22-24)gGa>gAa	p.G8E		NM_181599.2	NP_853630.2	Q8IUC0	KR131_HUMAN	keratin associated protein 13-1	8						intermediate filament		p.G8E(1)		endometrium(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGCTGCTCTGGAAACTTCTCC	0.532000													16	93					0	0	0.520397	0	0
GRHL1	29841	broad.mit.edu	37	2	10102598	10102598	+	Silent	SNP	G	G	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:10102598G>C	ENST00000324907.9	+	5	820	c.684G>C	c.(682-684)tcG>tcC	p.S228S	GRHL1_ENST00000405379.2_Silent_p.S228S|GRHL1_ENST00000324883.5_Intron	NM_198182.2	NP_937825.2	Q9NZI5	GRHL1_HUMAN	grainyhead-like 1 (Drosophila)	228					cellular lipid metabolic process|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding	p.S228S(1)		cervix(1)|endometrium(1)|large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	17	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.246)		TCTTCCCCTCGGATCTCAGTC	0.383000													3	23					0	0	0.150653	0	0
GSTP1	2950	broad.mit.edu	37	11	67353590	67353590	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:67353590G>T	ENST00000398606.3	+	6	601	c.352G>T	c.(352-354)Gac>Tac	p.D118Y	GSTP1_ENST00000498765.1_3'UTR|GSTP1_ENST00000398603.1_Intron	NM_000852.3	NP_000843.1	P09211	GSTP1_HUMAN	glutathione S-transferase pi 1	118	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding	p.D118Y(1)		central_nervous_system(1)|cervix(1)|endometrium(4)|lung(2)|ovary(1)	9					Ethacrynic acid(DB00903)|Glutathione(DB00143)	GGGCAAGGATGACTATGTGAA	0.597000													5	6					0.000602214	0.000671541	0.184627	1	0
WNT8A	7478	broad.mit.edu	37	5	137426515	137426515	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:137426515C>T	ENST00000506684.1	+	5	1099	c.863C>T	c.(862-864)aCa>aTa	p.T288I	WNT8A_ENST00000398754.1_Missense_Mutation_p.T270I			Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family, member 8A	270					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity	p.T270I(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATCTATGGCACAGAGGGTCGT	0.572000													12	44					0	0	0.387290	0	0
HTRA4	203100	broad.mit.edu	37	8	38832622	38832622	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr8:38832622C>T	ENST00000302495.4	+	2	639	c.539C>T	c.(538-540)tCg>tTg	p.S180L		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	180					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity	p.S180L(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GTGGCGCCATCGGTGGTTCAC	0.572000													5	121					0	0	0.217242	0	0
SKIV2L	6499	broad.mit.edu	37	6	31927176	31927176	+	Splice_Site	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:31927176G>A	ENST00000375394.2	+	2	238	c.126_splice	c.e2+1	p.S42_splice	SKIV2L_ENST00000488648.1_3'UTR|SKIV2L_ENST00000544581.1_5'UTR	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	42						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding	p.S42N(1)		breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						CCAGAGAGTAGCGTGAGTGAC	0.572000													45	112					0	0	0.853193	0	0
TKTL2	84076	broad.mit.edu	37	4	164394569	164394569	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:164394569G>A	ENST00000280605.3	-	1	478	c.318C>T	c.(316-318)agC>agT	p.S106S		NM_032136.4	NP_115512.3	Q9H0I9	TKTL2_HUMAN	transketolase-like 2	106						cytoplasm	metal ion binding|transketolase activity	p.S106S(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(42)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	70	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				TCTCCAAGTCGCTGTGAAGTT	0.537000													8	15					0	0	0.278610	0	0
MIR99AHG	388815	broad.mit.edu	37	21	17443549	17443549	+	RNA	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:17443549A>G	ENST00000458468.1	+	0	143					NR_027790.1													p.Y39C(1)									GGGTGCCACTACTATGGAGAC	0.547000													30	69					0	0	0.729181	0	0
LAMA2	3908	broad.mit.edu	37	6	129785559	129785559	+	Missense_Mutation	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:129785559T>A	ENST00000421865.2	+	50	7166	c.7117T>A	c.(7117-7119)Tcg>Acg	p.S2373T		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2373	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity	p.S2373T(1)		NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AACATTTTCTTCGAGTGCTCT	0.428000													37	122					0	0	0.834066	0	0
TCF12	6938	broad.mit.edu	37	15	57544626	57544626	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:57544626G>T	ENST00000438423.2	+	15	1492	c.1196G>T	c.(1195-1197)cGa>cTa	p.R399L	TCF12_ENST00000557843.1_Intron|TCF12_ENST00000267811.5_Intron|TCF12_ENST00000543579.1_Missense_Mutation_p.R229L|TCF12_ENST00000559710.1_Intron|TCF12_ENST00000560764.1_Intron|TCF12_ENST00000537840.1_Intron|TCF12_ENST00000343827.3_Intron|TCF12_ENST00000333725.5_Missense_Mutation_p.R399L|TCF12_ENST00000559703.1_Missense_Mutation_p.R33L|TCF12_ENST00000452095.2_Missense_Mutation_p.R395L	NM_207036.1|NM_207037.1	NP_996919.1|NP_996920.1	Q99081	HTF4_HUMAN	transcription factor 12	396					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity	p.R399L(2)	TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		CAGAAAAATCGAGTTGAGCAG	0.398000			T	TEC	extraskeletal myxoid chondrosarcoma								16	23					9.16793e-09	1.24477e-08	0.520397	1	0
CRB2	286204	broad.mit.edu	37	9	126137497	126137497	+	Splice_Site	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:126137497T>A	ENST00000373631.3	+	12	3509	c.3506_splice	c.e12-1	p.C1170_splice	CRB2_ENST00000373629.2_Splice_Site_p.C838_splice	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	1170	EGF-like 14.					extracellular region|integral to membrane|plasma membrane	calcium ion binding	p.C1170S(1)		NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						CCTCTCCAGGTGTCAGGTCCC	0.617000													32	19					0	0	0.804634	0	0
AP3B2	8120	broad.mit.edu	37	15	83333195	83333195	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:83333195C>A	ENST00000261722.3	-	18	2335	c.2128G>T	c.(2128-2130)Ggc>Tgc	p.G710C	AP3B2_ENST00000535359.1_Missense_Mutation_p.G729C|RP11-752G15.3_ENST00000560650.1_RNA|AP3B2_ENST00000535348.1_Missense_Mutation_p.G678C	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	710	Glu/Ser-rich.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity	p.G709C(1)		breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			TCCCCAGAGCCGCTCTCACTG	0.562000													5	15					0.014758	0.0154483	0.184627	1	0
VSTM1	284415	broad.mit.edu	37	19	54561767	54561767	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:54561767G>T	ENST00000338372.2	-	3	323	c.148C>A	c.(148-150)Cag>Aag	p.Q50K	VSTM1_ENST00000425006.2_Missense_Mutation_p.Q50K|VSTM1_ENST00000366170.2_Intron|VSTM1_ENST00000376626.1_Missense_Mutation_p.Q50K	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	50	Ig-like V-type.					integral to membrane		p.Q50K(1)		breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GAATGAGCCTGACACTTCAGG	0.532000													12	91					1.5842e-08	2.13752e-08	0.435327	1	0
CXXC11	285093	broad.mit.edu	37	2	242814382	242814382	+	Silent	SNP	T	T	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:242814382T>A	ENST00000343216.3	+	2	703	c.675T>A	c.(673-675)ccT>ccA	p.P225P		NM_173821.2	NP_776182.2	Q14D33	CB085_HUMAN	CXXC finger protein 11	225						integral to membrane		p.P225Q(1)									CTGCCCCCCCTGCGGGGGCCT	0.662000													13	24					0	0	0.435327	0	0
STAT5B	6777	broad.mit.edu	37	17	40364013	40364013	+	Nonsense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:40364013G>A	ENST00000293328.3	-	13	1837	c.1669C>T	c.(1669-1671)Cag>Tag	p.Q557*		NM_012448.3	NP_036580.2	P51692	STA5B_HUMAN	signal transducer and activator of transcription 5B	557					2-oxoglutarate metabolic process|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|fatty acid metabolic process|isoleucine metabolic process|JAK-STAT cascade involved in growth hormone signaling pathway|oxaloacetate metabolic process|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cytosol|nucleoplasm	calcium ion binding|glucocorticoid receptor binding|sequence-specific DNA binding transcription factor activity	p.Q557*(1)		breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_cancers(22;4.15e-07)|all_epithelial(22;2.83e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.135)	Dasatinib(DB01254)	CTGTTGAACTGGGACCAGGAC	0.587000													4	10					0	0	0.150653	0	0
ZNF177	7730	broad.mit.edu	37	19	9492374	9492374	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:9492374A>T	ENST00000541595.2	+	12	1516	c.887A>T	c.(886-888)cAg>cTg	p.Q296L	ZNF177_ENST00000602856.1_3'UTR|ZNF177_ENST00000602738.1_Missense_Mutation_p.Q296L|ZNF177_ENST00000343499.4_Missense_Mutation_p.Q296L|ZNF177_ENST00000589262.1_Missense_Mutation_p.Q456L|ZNF177_ENST00000446085.4_3'UTR|ZNF177_ENST00000434737.2_Missense_Mutation_p.Q456L|ZNF177_ENST00000590616.1_Intron	NM_001172650.2	NP_001166121.1	Q13360	ZN177_HUMAN	zinc finger protein 177	296					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q296L(1)|p.Q456L(1)		breast(1)|endometrium(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|stomach(2)	13						AAATGTATTCAGTGTGAAAAA	0.428000													45	57					0	0	0.859065	0	0
PAPPA2	60676	broad.mit.edu	37	1	176564445	176564445	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:176564445G>A	ENST00000367662.3	+	3	2869	c.1705G>A	c.(1705-1707)Gtc>Atc	p.V569I	PAPPA2_ENST00000367661.3_Missense_Mutation_p.V569I	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	569	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding	p.V569I(2)		NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GCAGCTGAGCGTCCACCAGGT	0.567000													23	53					0	0	0.608945	0	0
IGKV2-24	28923	broad.mit.edu	37	2	89475847	89475847	+	RNA	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:89475847C>A	ENST00000484817.1	-	0	354																											TAATAAACCCCGACATCCTCA	0.517000													41	94					1.22674e-20	2.23013e-20	0.840704	1	0
OR56A3	390083	broad.mit.edu	37	11	5968952	5968952	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:5968952C>A	ENST00000329564.6	+	1	383	c.376C>A	c.(376-378)Cgt>Agt	p.R126S		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R126S(1)		endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GGCCTATGATCGTTATGTAGC	0.458000													28	65					1.55811e-20	2.82462e-20	0.729181	1	0
RPGRIP1	57096	broad.mit.edu	37	14	21795831	21795831	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:21795831A>T	ENST00000206660.6	+	17	2760	c.2760A>T	c.(2758-2760)caA>caT	p.Q920H	RPGRIP1_ENST00000382933.4_Missense_Mutation_p.Q246H|RPGRIP1_ENST00000307974.4_Missense_Mutation_p.Q279H|RPGRIP1_ENST00000556336.1_Missense_Mutation_p.Q577H|RPGRIP1_ENST00000400017.2_Missense_Mutation_p.Q920H|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.Q882H			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	920					response to stimulus|visual perception	cilium		p.Q920H(1)|p.Q536H(1)		breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		GATCTATTCAAGTGCAACTGG	0.428000													19	31					0	0	0.592651	0	0
FBXL19	54620	broad.mit.edu	37	16	30941500	30941500	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:30941500G>T	ENST00000338343.4	+	7	1283	c.896G>T	c.(895-897)cGg>cTg	p.R299L	FBXL19_ENST00000565690.1_Missense_Mutation_p.R183L|FBXL19_ENST00000562319.1_Missense_Mutation_p.R299L|FBXL19_ENST00000380310.2_Missense_Mutation_p.R319L|FBXL19_ENST00000471231.2_Missense_Mutation_p.R7L			Q6PCT2	FXL19_HUMAN	F-box and leucine-rich repeat protein 19	319	Pro-rich.						DNA binding|zinc ion binding	p.R319L(1)|p.R149L(1)		breast(2)|endometrium(3)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						CTGCTGGAACGGGTGCCTGAC	0.657000													17	41					1.67942e-08	2.26044e-08	0.539581	1	0
TBX22	50945	broad.mit.edu	37	X	79278703	79278703	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:79278703A>G	ENST00000373294.5	+	2	348	c.320A>G	c.(319-321)gAc>gGc	p.D107G	TBX22_ENST00000442340.1_5'UTR|TBX22_ENST00000373291.1_5'UTR|TBX22_ENST00000373296.3_Missense_Mutation_p.D107G	NM_016954.2	NP_058650.1	Q9Y458	TBX22_HUMAN	T-box 22	107					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.D107G(1)		breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						AGATTCCATGACATCGGGACT	0.488000													20	10					0	0	0.592651	0	0
STRN	6801	broad.mit.edu	37	2	37111118	37111118	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:37111118G>T	ENST00000263918.4	-	9	1151	c.1143C>A	c.(1141-1143)agC>agA	p.S381R	STRN_ENST00000379213.2_Missense_Mutation_p.S332R	NM_003162.3	NP_003153.2	O43815	STRN_HUMAN	striatin, calmodulin binding protein	381					dendrite development|locomotory behavior|negative regulation of cell proliferation|tight junction assembly|Wnt receptor signaling pathway	cytoplasm|dendritic spine|neuronal cell body|postsynaptic density|postsynaptic membrane|tight junction	armadillo repeat domain binding|calmodulin binding|estrogen receptor binding|protein complex binding|protein phosphatase 2A binding	p.S381R(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33		Ovarian(717;0.0129)|all_hematologic(82;0.21)				GCCTGGAGCTGCTGGGTCTGG	0.408000													8	26					5.18039e-06	6.30783e-06	0.278610	1	0
ENGASE	64772	broad.mit.edu	37	17	77079627	77079627	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:77079627G>T	ENST00000579016.1	+	9	1206	c.1206G>T	c.(1204-1206)acG>acT	p.T402T	ENGASE_ENST00000584568.1_3'UTR	NM_001042573.2	NP_001036038.1	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	402						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity	p.T402T(2)		breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						CTTTCGTCACGTCCTTCTGCC	0.632000													6	31					0.0215528	0.0223804	0.217242	1	0
DMD	1756	broad.mit.edu	37	X	32430028	32430028	+	Silent	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chrX:32430028A>T	ENST00000357033.4	-	30	4280	c.4074T>A	c.(4072-4074)gcT>gcA	p.A1358A	DMD_ENST00000378677.2_Silent_p.A1354A	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1358					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.A1354A(1)|p.A17A(1)|p.A1353A(1)|p.A1358A(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GCCTCCTTACAGCCTAAAAAG	0.393000													18	3					0	0	0.557998	0	0
PCDHB13	56123	broad.mit.edu	37	5	140595689	140595689	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:140595689G>T	ENST00000341948.4	+	1	2181	c.1994G>T	c.(1993-1995)gGc>gTc	p.G665V		NM_018933.2	NP_061756.1	Q9Y5F0	PCDBD_HUMAN		665	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.G665V(1)		NS(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(4)|lung(24)|ovary(5)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	66			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGGTGGACGGCTTCTCCCAG	0.706000													26	61					1.66031e-10	2.416e-10	0.667858	1	0
PDCD4	27250	broad.mit.edu	37	10	112641277	112641277	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:112641277G>T	ENST00000393104.2	+	4	657	c.297G>T	c.(295-297)agG>agT	p.R99S	PDCD4_ENST00000280154.7_Missense_Mutation_p.R110S	NM_145341.3	NP_663314.1	Q53EL6	PDCD4_HUMAN	programmed cell death 4 (neoplastic transformation inhibitor)	110					apoptosis|cell aging|negative regulation of cell cycle|negative regulation of JUN kinase activity|negative regulation of transcription, DNA-dependent	cytosol|nucleus	protein binding|RNA binding	p.R110S(1)		breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	13		Breast(234;0.0848)|Lung NSC(174;0.238)		Epithelial(162;0.000526)|all cancers(201;0.00794)|BRCA - Breast invasive adenocarcinoma(275;0.125)		GGAAAGGAAGGGGACTACCAA	0.443000													10	23					0.000442599	0.000498693	0.335167	1	0
ZNF829	374899	broad.mit.edu	37	19	37383322	37383322	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:37383322A>T	ENST00000520965.1	-	6	680	c.614T>A	c.(613-615)tTc>tAc	p.F205Y	ZNF345_ENST00000432005.2_Intron|ZNF345_ENST00000526123.1_Intron|ZNF829_ENST00000391711.3_Missense_Mutation_p.F124Y	NM_001171979.1	NP_001165450.1	Q3KNS6	ZN829_HUMAN	zinc finger protein 829	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F124Y(1)		endometrium(2)|kidney(1)|large_intestine(11)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TACTTGACTGAAATGTCTCTT	0.338000													6	71					0	0	0.217242	0	0
ERCC6-PGBD3	101243544	broad.mit.edu	37	10	50724060	50724060	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr10:50724060C>A	ENST00000515869.1	-	6	2625	c.2505G>T	c.(2503-2505)atG>atT	p.M835I	ERCC6_ENST00000355832.5_Intron|PGBD3_ENST00000374127.3_Missense_Mutation_p.M367I|PGBD3_ENST00000603152.1_Missense_Mutation_p.M835I|PGBD3_ENST00000508005.2_Missense_Mutation_p.M367I|ERCC6-PGBD3_ENST00000447839.2_Missense_Mutation_p.M835I	NM_001277059.1	NP_001263988.1												p.M367I(1)									CCTGATGTCCCATTGAACTGA	0.393000													29	49					0.000184323	0.000212479	0.717897	1	0
EVC2	132884	broad.mit.edu	37	4	5570330	5570330	+	Missense_Mutation	SNP	A	A	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:5570330A>T	ENST00000310917.2	-	20	3889	c.3158T>A	c.(3157-3159)aTg>aAg	p.M1053K	EVC2_ENST00000344408.5_Missense_Mutation_p.M1133K|EVC2_ENST00000344938.1_Missense_Mutation_p.M1133K	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1133						integral to membrane		p.M1133N(1)		NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CCCGGGCACCATGGCCATCCT	0.602000													7	8					0	0	0.248553	0	0
ITIH1	3697	broad.mit.edu	37	3	52825805	52825805	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:52825805C>T	ENST00000273283.2	+	22	2638	c.2614C>T	c.(2614-2616)Caa>Taa	p.Q872*	ITIH1_ENST00000405128.3_Nonsense_Mutation_p.Q238*|ITIH1_ENST00000537050.1_Nonsense_Mutation_p.Q584*|ITIH1_ENST00000540715.1_Nonsense_Mutation_p.Q730*|ITIH1_ENST00000542827.1_3'UTR	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	872	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity	p.Q872*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		CAGGGGTTTGCAAAAAGACTA	0.577000													4	31					0	0	0.150653	0	0
MYLK	4638	broad.mit.edu	37	3	123452795	123452795	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:123452795C>T	ENST00000360772.3	-	11	1426	c.1048G>A	c.(1048-1050)Gca>Aca	p.A350T	MYLK_ENST00000346322.5_Missense_Mutation_p.A350T|MYLK_ENST00000475616.1_Missense_Mutation_p.A350T|MYLK_ENST00000360304.3_Missense_Mutation_p.A350T|MYLK_ENST00000359169.1_Missense_Mutation_p.A350T			Q15746	MYLK_HUMAN	myosin light chain kinase	350					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity	p.A350T(1)|p.A350P(1)|p.A350S(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGAACTCTTGCGGCCTGCAGG	0.632000													4	107					0	0	0.217242	0	0
TAB2	23118	broad.mit.edu	37	6	149700010	149700010	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:149700010G>T	ENST00000367456.1	+	4	1536	c.959G>T	c.(958-960)gGa>gTa	p.G320V	TAB2_ENST00000538427.1_Missense_Mutation_p.G320V|TAB2_ENST00000286332.5_Missense_Mutation_p.G320V|TAB2_ENST00000392282.1_Missense_Mutation_p.G320V|TAB2_ENST00000536230.1_Missense_Mutation_p.G288V			Q9NYJ8	TAB2_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 2	320					activation of MAPK activity|heart development|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	K63-linked polyubiquitin binding|zinc ion binding	p.G320V(1)		breast(2)|endometrium(6)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|urinary_tract(1)	22						ATTTCAACAGGACCTCGAAAA	0.413000													19	47					3.99206e-14	6.4289e-14	0.557998	1	0
SPATA31E1	286234	broad.mit.edu	37	9	90501444	90501444	+	Missense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:90501444C>T	ENST00000325643.5	+	4	2108	c.2042C>T	c.(2041-2043)tCt>tTt	p.S681F		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1									p.S681F(1)									TCCCAGCCTTCTGACTTTGCA	0.612000													9	40					0	0	0.361761	0	0
HDAC9	9734	broad.mit.edu	37	7	18687575	18687575	+	Silent	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:18687575T>C	ENST00000406451.3	+	10	1344	c.1194T>C	c.(1192-1194)caT>caC	p.H398H	HDAC9_ENST00000417496.2_Silent_p.H396H|HDAC9_ENST00000401921.1_Silent_p.H357H|HDAC9_ENST00000428307.2_Silent_p.H354H|HDAC9_ENST00000432645.2_Silent_p.H398H|HDAC9_ENST00000524023.1_Silent_p.H321H|HDAC9_ENST00000441542.2_Silent_p.H401H|HDAC9_ENST00000406072.1_Silent_p.H385H|HDAC9_ENST00000456174.2_Silent_p.H370H|HDAC9_ENST00000405010.3_Silent_p.H398H	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	398					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity	p.H401H(2)|p.H398H(1)|p.H396H(1)		breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TCCTGCAGCATTTATTATTGA	0.458000													5	14					0	0	0.184627	0	0
GSTA2	2939	broad.mit.edu	37	6	52617725	52617725	+	Missense_Mutation	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:52617725G>A	ENST00000493422.1	-	5	496	c.341C>T	c.(340-342)cCt>cTt	p.P114L		NM_000846.4	NP_000837.3	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2	114	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity	p.P114L(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	TTGTTCCTCAGGTTGACTAAA	0.388000													4	244					0	0	0.150653	0	0
LCT	3938	broad.mit.edu	37	2	136561527	136561527	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:136561527C>A	ENST00000264162.2	-	11	4646	c.4636G>T	c.(4636-4638)Ggc>Tgc	p.G1546C		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	1546	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity	p.G1546S(1)|p.G1546C(1)		breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		TAGCCATAGCCCTGGTAAGCA	0.498000													8	21					1.12685e-05	1.35682e-05	0.307466	1	0
OR52N2	390077	broad.mit.edu	37	11	5841931	5841931	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:5841931G>T	ENST00000317037.2	+	1	388	c.366G>T	c.(364-366)ctG>ctT	p.L122L	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L122L(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATGGCCCTGGACCGCTATG	0.537000													8	52					5.4927e-09	7.68268e-09	0.307466	1	0
IFI16	3428	broad.mit.edu	37	1	159021489	159021489	+	Silent	SNP	T	T	C			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:159021489T>C	ENST00000295809.7	+	10	1941	c.1686T>C	c.(1684-1686)acT>acC	p.T562T	IFI16_ENST00000368131.4_Silent_p.T506T|IFI16_ENST00000368132.3_Silent_p.T506T|IFI16_ENST00000340979.6_Silent_p.T450T|IFI16_ENST00000430894.2_Silent_p.T510T|IFI16_ENST00000359709.3_Silent_p.T506T|IFI16_ENST00000448393.2_Silent_p.T450T			Q16666	IF16_HUMAN	interferon, gamma-inducible protein 16	562	HIN-200 2.				cell proliferation|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|monocyte differentiation|negative regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	cytoplasm|nuclear speck|nucleolus	double-stranded DNA binding|protein binding	p.E507*(1)		cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29	all_hematologic(112;0.0429)					GACTGAAGACTGAACCTGAAG	0.428000													26	45					0	0	0.706142	0	0
TRAF6	7189	broad.mit.edu	37	11	36511949	36511949	+	Silent	SNP	G	G	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:36511949G>A	ENST00000526995.1	-	7	1254	c.1008C>T	c.(1006-1008)acC>acT	p.T336T	TRAF6_ENST00000529150.1_5'UTR|TRAF6_ENST00000348124.5_Silent_p.T336T	NM_004620.3	NP_004611.1	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	336	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding	p.T336T(1)		NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)	27	all_lung(20;0.211)	all_hematologic(20;0.107)				TGTCCTCAAGGGTTCGAATGG	0.423000													21	110					0	0	0.639603	0	0
CDH10	1008	broad.mit.edu	37	5	24487843	24487843	+	Silent	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:24487843G>T	ENST00000264463.4	-	12	2803	c.2296C>A	c.(2296-2298)Cga>Aga	p.R766R	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	766					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R766*(1)|p.R766R(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CCCCATTCTCGGAGGTAATCG	0.413000										HNSCC(23;0.051)			146	93					6.69687e-66	1.32105e-65	0.870114	1	0
KPRP	448834	broad.mit.edu	37	1	152732371	152732371	+	Nonsense_Mutation	SNP	C	C	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:152732371C>T	ENST00000368773.1	+	2	365	c.307C>T	c.(307-309)Caa>Taa	p.Q103*	KPRP_ENST00000606109.1_Nonsense_Mutation_p.Q103*	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	103	Gln-rich.					cytoplasm		p.Q103*(1)		NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATCCCAATCTCAAACTTCCTC	0.537000													6	242					0	0	0.217242	0	0
RYR3	6263	broad.mit.edu	37	15	33895391	33895391	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:33895391C>A	ENST00000389232.4	+	18	2060	c.1990C>A	c.(1990-1992)Ctg>Atg	p.L664M	RYR3_ENST00000415757.3_Missense_Mutation_p.L664M	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	664	B30.2/SPRY 1.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity	p.L664M(1)		NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GTACTTCGAGCTGATTATCGA	0.567000													15	97					3.45872e-05	4.09618e-05	0.500413	1	0
MYH7	4625	broad.mit.edu	37	14	23884706	23884706	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr14:23884706G>T	ENST00000355349.3	-	36	5329	c.5167C>A	c.(5167-5169)Ctc>Atc	p.L1723I	CTD-2201G16.1_ENST00000557368.1_RNA	NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1723					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.L1723I(1)		NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		TGGTTGATGAGGCTGGTGTTC	0.557000													13	36					0.00136819	0.00150757	0.411799	1	0
IGSF3	3321	broad.mit.edu	37	1	117122093	117122093	+	Missense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:117122093C>A	ENST00000369486.3	-	10	4020	c.3255G>T	c.(3253-3255)tgG>tgT	p.W1085C	IGSF3_ENST00000318837.6_Missense_Mutation_p.W1105C|IGSF3_ENST00000369483.1_Missense_Mutation_p.W1105C	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	1085	Ig-like C2-type 8.					integral to membrane		p.W1105C(1)|p.W1085C(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GGCTGGGCAGCCACTCCTCCA	0.592000													17	29					1.5739e-10	2.31623e-10	0.500413	1	0
KIAA0556	23247	broad.mit.edu	37	16	27751579	27751579	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:27751579A>G	ENST00000261588.4	+	15	1980	c.1961A>G	c.(1960-1962)gAg>gGg	p.E654G		NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	654								p.E654G(2)		breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GGGGACAAGGAGCTTGGTCTC	0.507000													9	48					0	0	0.335167	0	0
MEGF6	1953	broad.mit.edu	37	1	3511967	3511967	+	Missense_Mutation	SNP	G	G	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:3511967G>T	ENST00000356575.4	-	3	537	c.311C>A	c.(310-312)gCc>gAc	p.A104D		NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	104	EMI.					extracellular region	calcium ion binding	p.A104D(1)		cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CACGGTCCGGGCCTCCGTGGT	0.642000													13	25					0.00498961	0.00534366	0.520397	1	0
PGK2	5232	broad.mit.edu	37	6	49754274	49754274	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:49754274C>A	ENST00000304801.3	-	1	779	c.627G>T	c.(625-627)ctG>ctT	p.L209L		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	209					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity	p.L209L(1)		autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					CAAGTATAGCCAGAAAGGGTC	0.428000													35	84					4.34311e-12	6.64782e-12	0.779181	1	0
SV2A	9900	broad.mit.edu	37	1	149879341	149879341	+	Missense_Mutation	SNP	A	A	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:149879341A>G	ENST00000369146.3	-	10	2079	c.1589T>C	c.(1588-1590)cTg>cCg	p.L530P	SV2A_ENST00000369145.1_Missense_Mutation_p.L530P	NM_014849.3	NP_055664.3	Q7L0J3	SV2A_HUMAN	synaptic vesicle glycoprotein 2A	530					neurotransmitter transport	cell junction|endoplasmic reticulum|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity	p.L530P(1)		breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(6)|pancreas(1)|prostate(8)|skin(2)|urinary_tract(2)	55	Breast(34;0.00769)|all_hematologic(923;0.127)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)		Levetiracetam(DB01202)	CTCTTCAAACAGGGAATCCTC	0.502000													19	49					0	0	0.575678	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43858522	43858522	+	Nonsense_Mutation	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr12:43858522C>A	ENST00000389420.3	-	10	1380	c.1381G>T	c.(1381-1383)Gaa>Taa	p.E461*	ADAMTS20_ENST00000553158.1_Nonsense_Mutation_p.E461*	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	461	Peptidase M12B.					proteinaceous extracellular matrix	zinc ion binding	p.E461*(2)		breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGAAGACATTCCCCGTAACCA	0.363000													10	17					1.76689e-08	2.35949e-08	0.335167	1	0
GPR149	344758	broad.mit.edu	37	3	154147360	154147360	+	Silent	SNP	C	C	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:154147360C>A	ENST00000389740.2	-	1	144	c.45G>T	c.(43-45)ctG>ctT	p.L15L		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	15						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.L15L(1)		autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TCTCTTTCCACAGGCTAGAGT	0.353000													23	56					6.12954e-19	1.08988e-18	0.681144	1	0
USP33	23032	broad.mit.edu	37	1	78207349	78207349	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:78207349delC	ENST00000370793.1	-	3	473	c.127delG	c.(127-129)atfs	p.D43fs	USP33_ENST00000357428.1_Frame_Shift_Del_p.D43fs|USP33_ENST00000528150.1_5'UTR|USP33_ENST00000370792.3_Frame_Shift_Del_p.D43fs|USP33_ENST00000370794.3_Frame_Shift_Del_p.D12fs	NM_015017.4	NP_055832.3	Q8TEY7	UBP33_HUMAN	ubiquitin specific peptidase 33	43					axon guidance|cell migration|endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|VCB complex	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|prostate(2)|urinary_tract(1)	44						CCAACTGAATCCAAATGTGGA	0.313													7	36	---	---	---	---					
KCNA3	3738	broad.mit.edu	37	1	111216207	111216207	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:111216207delC	ENST00000369769.2	-	1	1448	c.1225delG	c.(1225-1227)tcfs	p.V409fs		NM_002232.3	NP_002223.3	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 3	409						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(7)|ovary(4)|pancreas(1)|prostate(3)|skin(1)	38		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAAGGATGACCCCAATAAAG	0.582													18	27	---	---	---	---					
NOS1AP	9722	broad.mit.edu	37	1	162326802	162326804	+	In_Frame_Del	DEL	CTT	CTT	-	rs41405649	by1000genomes	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:162326802_162326804delCTT	ENST00000361897.5	+	8	1217_1219	c.815_817delCTT	c.(814-819)cct>c	p.PS272del	NOS1AP_ENST00000530878.1_In_Frame_Del_p.PS267del	NM_001164757.1|NM_014697.2	NP_001158229.1|NP_055512.1	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	272					regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			ATGCTGCTCCCTTCTTCTTCCTC	0.611													30	266	---	---	---	---					
DUSP27	92235	broad.mit.edu	37	1	167097478	167097479	+	Frame_Shift_Ins	INS	-	-	A			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr1:167097478_167097479insA	ENST00000361200.2	+	6	3276_3277	c.3110_3111insA	c.(3109-3111)cgafs	p.R1037fs	DUSP27_ENST00000443333.1_Frame_Shift_Ins_p.R1037fs|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Frame_Shift_Ins_p.R1037fs			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1037					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GAGGAGAGCCCAGAGCCCTACT	0.584													25	46	---	---	---	---					
APOB	338	broad.mit.edu	37	2	21230280	21230280	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:21230280delC	ENST00000233242.1	-	26	9587	c.9460delG	c.(9460-9462)aafs	p.E3154fs		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3154					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CCTGTTTTTTCCCATAGAGAG	0.348													38	94	---	---	---	---					
ANKRD20A8P	729171	broad.mit.edu	37	2	95501983	95501983	+	RNA	DEL	G	G	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:95501983delG	ENST00000432432.2	-	0	937					NR_040113.1																						CCATAATCTTGGGAAAGGTCA	0.308													16	38	---	---	---	---					
ZNF804A	91752	broad.mit.edu	37	2	185731105	185731106	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr2:185731105_185731106delGA	ENST00000302277.6	+	2	715_716	c.121_122delGA	c.(121-123)gfs	p.E41fs		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	41						intracellular	zinc ion binding	p.E41Q(1)		NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GGACTATGCTGAGAAGGAAAAT	0.356													22	34	---	---	---	---					
ARPP21	10777	broad.mit.edu	37	3	35835223	35835223	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:35835223delC	ENST00000187397.4	+	20	2668	c.2212delC	c.(2212-2214)ccfs	p.P738fs	ARPP21_ENST00000337271.5_Frame_Shift_Del_p.P719fs|ARPP21_ENST00000476052.1_3'UTR|ARPP21_ENST00000444190.1_Frame_Shift_Del_p.P719fs|ARPP21_ENST00000417925.1_Frame_Shift_Del_p.P739fs|ARPP21_ENST00000458225.1_Frame_Shift_Del_p.P739fs	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	738	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						TCAAGGACTGCCCCAGCAGTC	0.488													14	44	---	---	---	---					
CELSR3	1951	broad.mit.edu	37	3	48688324	48688324	+	Splice_Site	DEL	C	C	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr3:48688324delC	ENST00000544264.1	-	15	6651		c.e15+1		CELSR3_ENST00000164024.4_Splice_Site			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3						homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGCCTGCTCACCCCGGCAGCC	0.657													22	40	---	---	---	---					
SLIT2	9353	broad.mit.edu	37	4	20550132	20550132	+	Frame_Shift_Del	DEL	A	A	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr4:20550132delA	ENST00000504154.1	+	23	2619	c.2367delA	c.(2365-2367)atfs	p.I789fs	SLIT2_ENST00000503837.1_Frame_Shift_Del_p.I785fs|SLIT2_ENST00000273739.5_Frame_Shift_Del_p.I793fs|SLIT2_ENST00000503823.1_Frame_Shift_Del_p.I781fs|SLIT2_ENST00000509394.2_3'UTR	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	789					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ACAACAGAATAAGCACGCTTT	0.368													10	43	---	---	---	---					
RFESD	317671	broad.mit.edu	37	5	94990059	94990059	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr5:94990059delG	ENST00000458310.1	+	5	1688	c.357delG	c.(355-357)ttfs	p.L119fs	RFESD_ENST00000513950.2_Intron|SPATA9_ENST00000477047.2_Intron|RFESD_ENST00000311364.4_Frame_Shift_Del_p.L66fs|RFESD_ENST00000380005.4_Frame_Shift_Del_p.L119fs	NM_001131065.1	NP_001124537.1	Q8TAC1	RFESD_HUMAN	Rieske (Fe-S) domain containing	66	Rieske 2.						2 iron, 2 sulfur cluster binding|metal ion binding|oxidoreductase activity			autonomic_ganglia(2)|endometrium(1)|large_intestine(1)|lung(1)|urinary_tract(1)	6		all_cancers(142;0.000215)|all_epithelial(76;7.43e-07)|all_lung(232;0.0318)|Lung NSC(167;0.041)|Ovarian(225;0.051)|Colorectal(57;0.162)		all cancers(79;5.94e-17)		CTTTACATTTGGGAGATATAG	0.249													30	43	---	---	---	---					
RRP36	88745	broad.mit.edu	37	6	42989414	42989419	+	In_Frame_Del	DEL	GCCGGG	GCCGGG	-	rs60664426		TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr6:42989414_42989419delGCCGGG	ENST00000244496.5	+	1	32_37	c.22_27delGCCGGG	c.(22-27)del	p.AG14del		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	14					ribosomal small subunit biogenesis|rRNA processing	nucleolus		p.A8_G9delAG(2)		NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						TAACTAccgcgccggggccggggccg	0.777													3	3	---	---	---	---					
HOXA3	3200	broad.mit.edu	37	7	27149826	27149827	+	Frame_Shift_Ins	INS	-	-	G			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:27149826_27149827insG	ENST00000396352.4	-	2	632_633	c.433_434insC	c.(433-435)gctfs	p.A145fs	HOXA-AS2_ENST00000518088.1_RNA|HOXA3_ENST00000317201.2_Frame_Shift_Ins_p.A145fs	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	145					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						TGAGTTGAGCAGGGGGCTCTTG	0.594													21	53	---	---	---	---					
CTTNBP2	83992	broad.mit.edu	37	7	117407198	117407198	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:117407198delC	ENST00000160373.3	-	9	2902	c.2811delG	c.(2809-2811)ggfs	p.G937fs		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	937										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CTGGCTCAAGCCCTCCGTGCC	0.443													29	75	---	---	---	---					
TBXAS1	6916	broad.mit.edu	37	7	139719828	139719830	+	In_Frame_Del	DEL	CCG	CCG	-	rs13306050	byFrequency	TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr7:139719828_139719830delCCG	ENST00000263552.6	+	17	2072_2074	c.1534_1536delCCG	c.(1534-1536)del	p.P512del	TBXAS1_ENST00000448866.1_In_Frame_Del_p.P511del|TBXAS1_ENST00000336425.5_In_Frame_Del_p.P511del|TBXAS1_ENST00000458722.1_In_Frame_Del_p.P557del|TBXAS1_ENST00000416849.2_In_Frame_Del_p.P558del|TBXAS1_ENST00000425687.1_In_Frame_Del_p.P444del|TBXAS1_ENST00000436047.2_In_Frame_Del_p.P512del|TBXAS1_ENST00000414508.2_In_Frame_Del_p.YR457del|TBXAS1_ENST00000411653.1_In_Frame_Del_p.YR456del	NM_001130966.2	NP_001124438.1	P24557	THAS_HUMAN	thromboxane A synthase 1 (platelet)	511			L -> P (in dbSNP:rs13306050).		hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	28	Melanoma(164;0.0142)					ATTTTAGGTACCGCTGCAGCTAG	0.458													7	36	---	---	---	---					
TRPM6	140803	broad.mit.edu	37	9	77502755	77502756	+	Frame_Shift_Ins	INS	-	-	T			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr9:77502755_77502756insT	ENST00000451710.3	-	1	254_255	c.17_18insA	c.(16-18)gttfs	p.V6fs	TRPM6_ENST00000359047.2_Frame_Shift_Ins_p.V6fs|TRPM6_ENST00000376872.3_Frame_Shift_Ins_p.V6fs|TRPM6_ENST00000376864.4_Frame_Shift_Ins_p.V6fs|TRPM6_ENST00000376871.3_Frame_Shift_Ins_p.V6fs|TRPM6_ENST00000360774.1_Frame_Shift_Ins_p.V6fs			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	6					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AGCGCTCCAAGACAGGTTGTTC	0.564													23	124	---	---	---	---					
MRGPRX1	259249	broad.mit.edu	37	11	18956058	18956058	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr11:18956058delG	ENST00000302797.3	-	1	498	c.274delC	c.(274-276)atfs	p.H92fs	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	92					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						GAGATGGTATGGGGGATACTG	0.517													16	142	---	---	---	---					
PGAM1P12	390643	broad.mit.edu	37	15	96984998	96984998	+	RNA	DEL	T	T	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr15:96984998delT	ENST00000559214.1	+	0	235																											TCAGAGGCTGTTGCCATGGGC	0.517													17	66	---	---	---	---					
C16orf71	146562	broad.mit.edu	37	16	4796953	4796955	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:4796953_4796955delGAG	ENST00000299320.5	+	8	1685_1687	c.1207_1209delGAG	c.(1207-1209)del	p.E409del	RP11-127I20.7_ENST00000588099.1_RNA|C16orf71_ENST00000590191.1_In_Frame_Del_p.E426del	NM_139170.2	NP_631909.2	Q8IYS4	CP071_HUMAN	chromosome 16 open reading frame 71	409								p.E403delE(1)		breast(1)|central_nervous_system(1)|large_intestine(4)|lung(4)|ovary(1)	11						CTCTGACAGTGAGGAGGAGGAGG	0.611													4	9	---	---	---	---					
NPIPA5	100288332	broad.mit.edu	37	16	15457788	15457788	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr16:15457788delG	ENST00000360151.4	-	8	780	c.781delC	c.(781-783)tgfs	p.L261fs		NM_001277325.1	NP_001264254.1			nuclear pore complex interacting protein family, member A5																		TTGAGGCTCAGGGAGTTATCA	0.517													26	17	---	---	---	---					
SPAG7	9552	broad.mit.edu	37	17	4864095	4864095	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr17:4864095delC	ENST00000575142.1	-	2	124	c.106delG	c.(106-108)agfs	p.E36fs	SPAG7_ENST00000206020.3_Frame_Shift_Del_p.E47fs|SPAG7_ENST00000573366.1_5'UTR			O75391	SPAG7_HUMAN	sperm associated antigen 7	47						nucleus	nucleic acid binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(3)|ovary(2)|urinary_tract(1)	10						TTACGAAACTCCACTTTCTGT	0.478													23	51	---	---	---	---					
ZNF226	7769	broad.mit.edu	37	19	44679818	44679818	+	Frame_Shift_Del	DEL	G	G	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr19:44679818delG	ENST00000590089.1	+	7	770	c.403delG	c.(403-405)ggfs	p.G135fs	ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000454662.2_Frame_Shift_Del_p.G135fs|ZNF226_ENST00000337433.5_Frame_Shift_Del_p.G135fs			Q9NYT6	ZN226_HUMAN	zinc finger protein 226	135					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				TTACCAGGTAGGGACAGAACT	0.383													28	28	---	---	---	---					
TSPEAR	54084	broad.mit.edu	37	21	45941951	45941951	+	Frame_Shift_Del	DEL	C	C	-			TCGA-64-5778-01A-01D-1625-08	TCGA-64-5778-10A-01D-1625-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	3c540f87-5981-4b7a-b1ab-30c2056c785e	6069cecc-5fc1-47fb-b64b-11e36726037b	g.chr21:45941951delC	ENST00000323084.4	-	9	1446	c.1381delG	c.(1381-1383)cafs	p.A461fs	C21orf90_ENST00000465978.1_Intron|TSPEAR_ENST00000397916.1_Frame_Shift_Del_p.A393fs	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	461					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						AGCCGGGTTGCCGGGTTCCAC	0.617													47	136	---	---	---	---					
