Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIAA1211	57482	broad.mit.edu	37	4	57189582	57189582	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr4:57189582C>G	ENST00000504228.1	+	7	3332	c.3227C>G	c.(3226-3228)tCc>tGc	p.S1076C	KIAA1211_ENST00000541073.1_Missense_Mutation_p.S1069C|KIAA1211_ENST00000264229.6_Missense_Mutation_p.S1076C			Q6ZU35	K1211_HUMAN	KIAA1211	1076								p.S1076C(1)		endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					TTAGATGGCTCCAAACTTACA	0.507000													4	40					0	0	0.184627	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24896491	24896491	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:24896491G>A	ENST00000396432.2	-	11	3107	c.2621C>T	c.(2620-2622)tCa>tTa	p.S874L	ARHGAP21_ENST00000320481.6_Missense_Mutation_p.S661L|ARHGAP21_ENST00000493154.1_5'UTR	NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	873					signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding	p.S873L(1)		NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TTCTGTCTTTGAGTTGGGCTG	0.358000													4	114					0	0	0.184627	0	0
DSCR9	257203	broad.mit.edu	37	21	38593890	38593890	+	RNA	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr21:38593890C>T	ENST00000454482.2	+	0	1497				AP001432.14_ENST00000440629.1_lincRNA	NR_026719.2																						CACCAAGACTCCAGAGCAGGT	0.517000													4	63					0	0	0.150653	0	0
FERMT3	83706	broad.mit.edu	37	11	63990575	63990575	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr11:63990575C>T	ENST00000279227.5	+	14	1833	c.1738C>T	c.(1738-1740)Cgc>Tgc	p.R580C	FERMT3_ENST00000345728.5_Missense_Mutation_p.R576C	NM_178443.2	NP_848537.1	Q86UX7	URP2_HUMAN	fermitin family member 3	580					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding	p.R580C(1)|p.R576C(1)		breast(1)|cervix(1)|endometrium(4)|large_intestine(2)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	18						CCGACTGATCCGCATCGACTT	0.627000													6	61					0	0	0.021553	0	0
KANK1	23189	broad.mit.edu	37	9	732583	732583	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr9:732583G>A	ENST00000382303.1	+	10	3863	c.3211G>A	c.(3211-3213)Gaa>Aaa	p.E1071K	KANK1_ENST00000382297.2_Missense_Mutation_p.E1071K|KANK1_ENST00000382293.3_Missense_Mutation_p.E913K|KANK1_ENST00000489369.1_3'UTR	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	1071					negative regulation of actin filament polymerization	cytoplasm		p.E913K(1)|p.E1071K(1)		autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GCAGGTTCAAGAATGTGAACC	0.488000													4	64					0	0	0.150653	0	0
CRYBB1	1414	broad.mit.edu	37	22	27012195	27012195	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr22:27012195C>T	ENST00000215939.2	-	2	219	c.89G>A	c.(88-90)gGa>gAa	p.G30E		NM_001887.3	NP_001878.1	P53674	CRBB1_HUMAN	crystallin, beta B1	30	N-terminal arm.				visual perception		structural constituent of eye lens	p.G30E(1)		breast(1)|endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(3)|skin(2)|urinary_tract(4)	31						AGGGGATGTTCCTGCAGGTGG	0.657000													5	86					0	0	0.029380	0	0
COL4A4	1286	broad.mit.edu	37	2	227886814	227886814	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr2:227886814C>T	ENST00000396625.3	-	44	4373	c.4166G>A	c.(4165-4167)gGa>gAa	p.G1389E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1386E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1389	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding	p.G1389E(1)		breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCCTTCTGGTCCTCTCATGCC	0.547000													7	200					0	0	0.029380	0	0
MYCT1	80177	broad.mit.edu	37	6	153043209	153043209	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr6:153043209C>T	ENST00000367245.5	+	2	537	c.529C>T	c.(529-531)Cct>Tct	p.P177S	MYCT1_ENST00000529453.1_Intron	NM_025107.2	NP_079383.2	Q8N699	MYCT1_HUMAN	myc target 1	177						nucleus		p.P177S(2)		NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	20		Ovarian(120;0.0654)		OV - Ovarian serous cystadenocarcinoma(155;1.33e-10)|BRCA - Breast invasive adenocarcinoma(81;0.143)		TCCACCACTTCCTGTGGAAAC	0.493000													10	58					0	0	0.080935	0	0
NFS1	9054	broad.mit.edu	37	20	34260738	34260738	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr20:34260738C>G	ENST00000374092.4	-	12	1319	c.1249G>C	c.(1249-1251)Gag>Cag	p.E417Q	NFS1_ENST00000374085.1_Missense_Mutation_p.E357Q|NFS1_ENST00000397425.1_Missense_Mutation_p.E357Q|NFS1_ENST00000541387.1_Missense_Mutation_p.E366Q|NFS1_ENST00000540053.1_Missense_Mutation_p.E215Q|NFS1_ENST00000498084.1_5'UTR	NM_021100.4	NP_066923.3	Q9Y697	NFS1_HUMAN	NFS1 cysteine desulfurase	417					cysteine metabolic process|iron incorporation into metallo-sulfur cluster|Mo-molybdopterin cofactor biosynthetic process|protein complex assembly|water-soluble vitamin metabolic process	cytosol|mitochondrial matrix|nucleus	cysteine desulfurase activity|protein homodimerization activity|pyridoxal phosphate binding	p.E417Q(1)		central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	18	Lung NSC(9;0.00608)|all_lung(11;0.00918)		BRCA - Breast invasive adenocarcinoma(18;0.0886)		L-Alanine(DB00160)|L-Cysteine(DB00151)|Pyridoxal Phosphate(DB00114)	TCCACTTCCTCCTCTGTAGTG	0.453000													3	55					0	0	0.115264	0	0
PTBP1	5725	broad.mit.edu	37	19	803570	803570	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:803570G>A	ENST00000356948.6	+	3	472	c.49G>A	c.(49-51)Gac>Aac	p.D17N	PTBP1_ENST00000394601.4_Missense_Mutation_p.D17N|PTBP1_ENST00000350092.4_Intron|PTBP1_ENST00000349038.4_Missense_Mutation_p.D17N	NM_002819.4	NP_002810.1	P26599	PTBP1_HUMAN	polypyrimidine tract binding protein 1	17					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding	p.D17N(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(4)	19		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGGGGATCTGACGAGCTTTT	0.627000													6	70					0	0	0.047766	0	0
USH2A	7399	broad.mit.edu	37	1	216419957	216419957	+	Nonsense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:216419957G>A	ENST00000366943.2	-	13	3165	c.2779C>T	c.(2779-2781)Caa>Taa	p.Q927*	USH2A_ENST00000307340.3_Nonsense_Mutation_p.Q927*|USH2A_ENST00000366942.3_Nonsense_Mutation_p.Q927*			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	927	Laminin EGF-like 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.Q927*(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTTCTTCCTTGACGATTAGGC	0.433000										HNSCC(13;0.011)			6	117					0	0	0.029380	0	0
TRIP4	9325	broad.mit.edu	37	15	64717779	64717779	+	Silent	SNP	G	G	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr15:64717779G>T	ENST00000261884.3	+	11	1584	c.1524G>T	c.(1522-1524)ctG>ctT	p.L508L		NM_016213.4	NP_057297.2	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	508					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding	p.L508L(2)		breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21						GTTGTCTTCTGGGCTGTGTGG	0.383000													35	106					9.73076e-26	1.0866e-25	0.092188	1	0
SHPRH	257218	broad.mit.edu	37	6	146266576	146266576	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr6:146266576T>A	ENST00000367503.3	-	8	1917	c.1519A>T	c.(1519-1521)Act>Tct	p.T507S	SHPRH_ENST00000275233.7_Missense_Mutation_p.T507S|SHPRH_ENST00000438092.2_Missense_Mutation_p.T507S|SHPRH_ENST00000367505.2_Missense_Mutation_p.T507S	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	507	H15.				DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding	p.T507S(1)		breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		AATGTAAAAGTCCCAGAAAAA	0.358000													6	74					0	0	0.021553	0	0
QRICH1	54870	broad.mit.edu	37	3	49095083	49095083	+	Nonsense_Mutation	SNP	C	C	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr3:49095083C>A	ENST00000395443.2	-	3	1022	c.550G>T	c.(550-552)Gaa>Taa	p.E184*	QRICH1_ENST00000479449.1_Intron|QRICH1_ENST00000424300.1_Nonsense_Mutation_p.E184*|QRICH1_ENST00000357496.2_Nonsense_Mutation_p.E184*	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	184	Gln-rich.							p.E184*(1)		breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		TCCGGGATTTCTGCAGCCTGG	0.602000													5	66					0.00116845	0.00124263	0.021553	1	0
ABCC9	10060	broad.mit.edu	37	12	22068751	22068751	+	Silent	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:22068751G>A	ENST00000261200.4	-	5	666	c.667C>T	c.(667-669)Ctg>Ttg	p.L223L	ABCC9_ENST00000261201.4_Silent_p.L223L|ABCC9_ENST00000345162.2_Silent_p.L223L	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	223					defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity	p.L223L(2)		NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCTTTTGACAGCAAATTCACA	0.393000													3	79					0	0	0.115264	0	0
MLST8	64223	broad.mit.edu	37	16	2258828	2258828	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr16:2258828C>T	ENST00000569417.1	+	9	1285	c.931C>T	c.(931-933)Cac>Tac	p.H311Y	MLST8_ENST00000565250.1_Missense_Mutation_p.H311Y|MLST8_ENST00000382450.4_Missense_Mutation_p.H310Y|MLST8_ENST00000564088.1_Missense_Mutation_p.H311Y|MLST8_ENST00000301724.10_3'UTR|MLST8_ENST00000397124.1_Missense_Mutation_p.H311Y|MLST8_ENST00000301725.7_3'UTR	NM_022372.4	NP_071767.3	Q9BVC4	LST8_HUMAN	MTOR associated protein, LST8 homolog (S. cerevisiae)	311					insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding	p.H311Y(1)		large_intestine(3)|lung(2)|skin(1)	6						GTATGGCGGCCACCAGAAGGC	0.622000													16	197					0	0	0.175082	0	0
SERPINF1	5176	broad.mit.edu	37	17	1675167	1675167	+	Splice_Site	SNP	G	G	A	rs138341386	byFrequency	TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:1675167G>A	ENST00000254722.4	+	5	604	c.439_splice	c.e5-1	p.K147_splice	SERPINF1_ENST00000571870.1_3'UTR	NM_002615.5	NP_002606.3	P36955	PEDF_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	147					cell proliferation|negative regulation of angiogenesis|positive regulation of neurogenesis|regulation of proteolysis	extracellular space|melanosome	serine-type endopeptidase inhibitor activity	p.K147K(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	16						TCTTCTCAGAGCTGCGCATAA	0.562000													12	12					0	0	0.132662	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													3	41					0	0	0.115264	0	0
EXOC3L4	91828	broad.mit.edu	37	14	103574737	103574737	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr14:103574737C>G	ENST00000380069.3	+	10	1935	c.1859C>G	c.(1858-1860)tCc>tGc	p.S620C		NM_001077594.1	NP_001071062.1	Q17RC7	EX3L4_HUMAN	exocyst complex component 3-like 4	620								p.S620C(1)		cervix(2)|endometrium(2)|lung(4)|ovary(1)|skin(1)	10						TCGCAGGGTTCCGAGGCCACA	0.637000													10	117					0	0	0.058154	0	0
FAM81A	145773	broad.mit.edu	37	15	59801128	59801128	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr15:59801128C>G	ENST00000288228.5	+	6	797	c.610C>G	c.(610-612)Cac>Gac	p.H204D		NM_152450.2	NP_689663.2	Q8TBF8	FA81A_HUMAN	family with sequence similarity 81, member A	204								p.H201D(1)		endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10						GAAGATGTCTCACAGAGACAG	0.338000													3	53					0	0	0.115264	0	0
CREM	1390	broad.mit.edu	37	10	35468111	35468111	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:35468111G>C	ENST00000333809.8	+	5	517	c.463G>C	c.(463-465)Gaa>Caa	p.E155Q	CREM_ENST00000342105.3_Missense_Mutation_p.E51Q|CREM_ENST00000374721.3_Missense_Mutation_p.E139Q|CREM_ENST00000337656.4_Missense_Mutation_p.E106Q|CREM_ENST00000395887.3_Missense_Mutation_p.E76Q|CREM_ENST00000354759.3_Missense_Mutation_p.E106Q|CREM_ENST00000474362.1_Intron|CREM_ENST00000395895.2_Missense_Mutation_p.E155Q|CREM_ENST00000348787.2_Missense_Mutation_p.E90Q|CREM_ENST00000374728.3_Missense_Mutation_p.E90Q|CREM_ENST00000374734.3_Missense_Mutation_p.E106Q|CREM_ENST00000361599.4_Missense_Mutation_p.E76Q|CREM_ENST00000489321.1_Missense_Mutation_p.E90Q|CREM_ENST00000463960.1_Missense_Mutation_p.E51Q|CREM_ENST00000489388.1_3'UTR|CREM_ENST00000463314.1_Intron|CREM_ENST00000345491.3_Missense_Mutation_p.E106Q|CREM_ENST00000460270.1_Intron|CREM_ENST00000374726.3_Missense_Mutation_p.E90Q|CREM_ENST00000484283.1_Missense_Mutation_p.E76Q|CREM_ENST00000439705.1_Missense_Mutation_p.E155Q|CREM_ENST00000479070.1_Missense_Mutation_p.E106Q|CREM_ENST00000429130.3_Missense_Mutation_p.E139Q	NM_183011.1	NP_898829.1	Q03060	CREM_HUMAN	cAMP responsive element modulator	155	KID.				cell differentiation|multicellular organismal development|signal transduction|spermatogenesis	nucleus	cAMP response element binding protein binding|protein binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.E106Q(1)|p.E90Q(1)|p.E76Q(1)		NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14						TCCCAAGATTGAAGAAGAGAG	0.393000													3	76					0	0	0.115264	0	0
DEAF1	10522	broad.mit.edu	37	11	679720	679720	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr11:679720G>A	ENST00000382409.3	-	8	1578	c.1094C>T	c.(1093-1095)cCg>cTg	p.P365L	DEAF1_ENST00000525904.1_5'UTR|DEAF1_ENST00000338675.6_Missense_Mutation_p.P276L	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	365					embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding	p.P365L(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GCCCTGGGCCGGACTCTCTGA	0.637000													6	41					0	0	0.029380	0	0
ZNF780A	284323	broad.mit.edu	37	19	40581559	40581559	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:40581559G>A	ENST00000450241.2	-	6	999	c.688C>T	c.(688-690)Ctt>Ttt	p.L230F	ZNF780A_ENST00000340963.5_Missense_Mutation_p.L264F|ZNF780A_ENST00000455521.1_Missense_Mutation_p.L265F|ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000594395.1_Missense_Mutation_p.L265F|ZNF780A_ENST00000595687.2_Missense_Mutation_p.L264F|AC005614.5_ENST00000595508.1_RNA			O75290	Z780A_HUMAN	zinc finger protein 780A	264					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.L230F(1)|p.L265F(1)		breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TGTTGAACAAGGTTTGAGCTA	0.398000													45	154					0	0	0.139131	0	0
ZNF852	285346	broad.mit.edu	37	3	44540772	44540772	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr3:44540772C>A	ENST00000436261.1	-	4	1657	c.1497G>T	c.(1495-1497)ttG>ttT	p.L499F				B6EU87	B6EU87_HUMAN	zinc finger protein 852	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.L499F(2)		endometrium(2)|kidney(1)|lung(5)	8						TTCCCACACTCAATACATTCA	0.468000													19	44					3.32936e-07	3.65684e-07	0.175082	1	0
NTF4	4909	broad.mit.edu	37	19	49564708	49564708	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:49564708C>T	ENST00000301411.3	-	2	687	c.547G>A	c.(547-549)Gat>Aat	p.D183N	NTF4_ENST00000593537.1_Missense_Mutation_p.D183N|NTF4_ENST00000451356.2_Intron	NM_006179.4	NP_006170.1	P34130	NTF4_HUMAN	neurotrophin 4	183					adult locomotory behavior|epidermis development|ganglion mother cell fate determination|long-term memory|sensory organ boundary specification	endoplasmic reticulum lumen|extracellular region	growth factor activity	p.D183N(1)		kidney(1)|lung(4)|upper_aerodigestive_tract(1)	6		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_epithelial(76;3.83e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)		CCCTGGGCATCAGCGGTCAAT	0.667000													6	34					0	0	0.021553	0	0
LPIN2	9663	broad.mit.edu	37	18	2954540	2954540	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr18:2954540C>G	ENST00000261596.4	-	3	488	c.250G>C	c.(250-252)Gga>Cga	p.G84R	RP11-737O24.2_ENST00000584431.1_RNA	NM_014646.2	NP_055461.1	Q92539	LPIN2_HUMAN	lipin 2	84	N-LIP.				fatty acid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|triglyceride biosynthetic process	cytosol|endoplasmic reticulum membrane|nucleus	phosphatidate phosphatase activity|transcription coactivator activity	p.G84R(1)		autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(4)|lung(16)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	29				READ - Rectum adenocarcinoma(2;0.0419)|Colorectal(6;0.156)		AAAGCTTCTCCGTTATCACCC	0.433000													7	75					0	0	0.047766	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86526912	86526912	+	Missense_Mutation	SNP	G	G	T	rs147564059		TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr7:86526912G>T	ENST00000450689.2	-	19	2780	c.2595C>A	c.(2593-2595)ttC>ttA	p.F865L	KIAA1324L_ENST00000297222.6_Missense_Mutation_p.F625L|KIAA1324L_ENST00000416314.1_Missense_Mutation_p.F698L|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.F794L	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	865						integral to membrane		p.F625L(1)|p.F625F(1)|p.F865L(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					ACAGGAAATAGAACGTACACC	0.458000													5	53					0.00198382	0.00207681	0.029380	1	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													3	44					0	0	0.115264	0	0
EFR3A	23167	broad.mit.edu	37	8	132996391	132996391	+	Silent	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr8:132996391G>A	ENST00000254624.5	+	15	1806	c.1581G>A	c.(1579-1581)ggG>ggA	p.G527G	EFR3A_ENST00000519656.1_Silent_p.G491G|EFR3A_ENST00000334503.4_Silent_p.G527G	NM_015137.4	NP_055952.2	Q14156	EFR3A_HUMAN	EFR3 homolog A (S. cerevisiae)	527						plasma membrane	binding	p.G527G(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(14)|ovary(3)|skin(1)|stomach(2)	35	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			CTCAGAATGGGCAACAGCTGT	0.348000													3	60					0	0	0.115264	0	0
ALG13	79868	broad.mit.edu	37	X	110961491	110961491	+	Silent	SNP	A	A	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chrX:110961491A>G	ENST00000394780.3	+	10	1251	c.1239A>G	c.(1237-1239)tcA>tcG	p.S413S	ALG13_ENST00000251943.4_Silent_p.S309S	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	413					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	p.S413S(1)|p.S309S(1)		endometrium(2)|lung(10)|skin(1)	13						ACAAGAGTTCAAATCAGAATA	0.373000													2	13					0	0	0.150653	0	0
ZNF331	55422	broad.mit.edu	37	19	54074859	54074859	+	Splice_Site	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:54074859G>A	ENST00000253144.9	+	6	1344	c.9_splice	c.e6-1	p.G4_splice	ZNF331_ENST00000449416.1_Splice_Site_p.G4_splice|ZNF331_ENST00000411977.2_Splice_Site_p.G4_splice|ZNF331_ENST00000511593.2_Splice_Site_p.G4_splice|ZNF331_ENST00000512387.1_Splice_Site_p.G4_splice|ZNF331_ENST00000513265.1_Splice_Site_p.G4_splice|ZNF331_ENST00000511154.1_Splice_Site_p.G4_splice|ZNF331_ENST00000513999.1_Splice_Site_p.G4_splice	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.G4D(1)		NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		CTGTTTCAGGGTTTGGTGACG	0.542000			T	?	follicular thyroid adenoma								41	503					0	0	0.139131	0	0
PARG	8505	broad.mit.edu	37	10	51093329	51093329	+	Missense_Mutation	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:51093329C>T	ENST00000402038.3	-	4	294	c.295G>A	c.(295-297)Gca>Aca	p.A99T		NM_003631.2	NP_003622.2	Q86W56	PARG_HUMAN	poly (ADP-ribose) glycohydrolase	584					carbohydrate metabolic process	nucleus	poly(ADP-ribose) glycohydrolase activity	p.A584T(1)		endometrium(5)|kidney(2)|lung(1)|ovary(2)	10				Epithelial(53;0.213)		TGAGCTTCTGCTTCTTCAAGT	0.318000													3	67					0	0	0.115264	0	0
FANCI	55215	broad.mit.edu	37	15	89824490	89824490	+	Silent	SNP	C	C	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr15:89824490C>T	ENST00000310775.7	+	15	1557	c.1471C>T	c.(1471-1473)Ctg>Ttg	p.L491L	FANCI_ENST00000300027.8_Silent_p.L491L	NM_001113378.1	NP_001106849.1	Q9NVI1	FANCI_HUMAN	Fanconi anemia, complementation group I	491					cell cycle|DNA repair	nucleoplasm	protein binding	p.L491L(2)		breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	Lung NSC(78;0.0472)|all_lung(78;0.089)					TTTGTCCTTTCTGCCCCTTCA	0.413000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				4	160					0	0	0.150653	0	0
TCL6	27004	broad.mit.edu	37	14	96134693	96134693	+	RNA	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr14:96134693C>G	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		CGTTACTATTCAAACTGCACA	0.488000			T	TRA@	T-ALL								4	42					0	0	0.150653	0	0
RTKN2	219790	broad.mit.edu	37	10	64000899	64000899	+	Splice_Site	SNP	A	A	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:64000899A>G	ENST00000373789.3	-	4	467		c.e4+1		RTKN2_ENST00000395260.3_Splice_Site|RTKN2_ENST00000395265.1_Splice_Site	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2						signal transduction	intracellular		p.?(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					AATCATACATACGTTCTTTAT	0.289000													3	35					0	0	0.115264	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54711811	54711811	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr5:54711811G>C	ENST00000230640.5	+	25	3076	c.2822G>C	c.(2821-2823)aGa>aCa	p.R941T	SKIV2L2_ENST00000545714.1_Missense_Mutation_p.R840T	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	941					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.R941T(1)		NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGTGCTAAAAGAATTGCAAAA	0.343000													3	51					0	0	0.115264	0	0
SNRPB2	6629	broad.mit.edu	37	20	16717952	16717952	+	Missense_Mutation	SNP	G	G	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr20:16717952G>T	ENST00000246071.6	+	4	500	c.284G>T	c.(283-285)cGt>cTt	p.R95L	SNRPB2_ENST00000377943.5_Missense_Mutation_p.R95L	NM_003092.4	NP_003083.1	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B	95						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding	p.R95L(1)		large_intestine(2)|lung(2)|urinary_tract(1)	5						TCAAAAATGCGTGGAACTTTT	0.348000													3	28					0.004672	0.00481575	0.115264	1	0
IL31	386653	broad.mit.edu	37	12	122657188	122657188	+	Missense_Mutation	SNP	C	C	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:122657188C>A	ENST00000377035.1	-	3	292	c.266G>T	c.(265-267)cGg>cTg	p.R89L		NM_001014336.1	NP_001014358.1	Q6EBC2	IL31_HUMAN	interleukin 31	89						extracellular space	cytokine activity	p.R89L(1)		central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;6.93e-05)|Breast(359;0.0544)		OV - Ovarian serous cystadenocarcinoma(86;3.27e-29)|Epithelial(86;4.86e-27)|BRCA - Breast invasive adenocarcinoma(302;0.223)		GAGATATGCCCGGATGGCTGG	0.507000													3	50					0.115264	0.11701	0.115264	1	0
HMGCR	3156	broad.mit.edu	37	5	74646703	74646703	+	Silent	SNP	A	A	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr5:74646703A>G	ENST00000287936.4	+	9	1026	c.870A>G	c.(868-870)tcA>tcG	p.S290S	HMGCR_ENST00000343975.5_Silent_p.S290S|HMGCR_ENST00000511206.1_Silent_p.S290S	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	290					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding	p.S290S(1)		breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	CTAAGGTTTCATTAGGACTGG	0.383000													7	103					0	0	0.038147	0	0
ARL17A	51326	broad.mit.edu	37	17	44594493	44594493	+	Silent	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:44594493G>C	ENST00000445552.2	-	4	452	c.366C>G	c.(364-366)ctC>ctG	p.L122L	LRRC37A2_ENST00000576629.1_Intron|ARL17A_ENST00000329240.4_Silent_p.L122L|LRRC37A2_ENST00000333412.3_Intron|ARL17A_ENST00000337845.7_3'UTR	NM_016632.2	NP_057716.2	Q8IVW1	ARL17_HUMAN	ADP-ribosylation factor-like 17A	0					protein transport|vesicle-mediated transport	Golgi apparatus	GTP binding	p.L122L(1)		lung(1)	1						ATCTGTCCAAGAGATGGGATG	0.388000													7	80					0	0	0.029380	0	0
EME1	146956	broad.mit.edu	37	17	48452594	48452594	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:48452594T>C	ENST00000393271.2	+	2	107	c.25T>C	c.(25-27)Tca>Cca	p.S9P	EME1_ENST00000338165.4_Missense_Mutation_p.S9P|EME1_ENST00000511648.2_Missense_Mutation_p.S9P	NM_001166131.1	NP_001159603.1	Q96AY2	EME1_HUMAN	essential meiotic structure-specific endonuclease 1	9					DNA recombination|DNA repair	nucleolus	DNA binding|endonuclease activity|metal ion binding|protein binding	p.S9P(1)		endometrium(4)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|stomach(2)|upper_aerodigestive_tract(1)	19	Breast(11;5.62e-19)		BRCA - Breast invasive adenocarcinoma(22;2.43e-08)			GTCATCACCCTCACTGGATTC	0.428000								Direct reversal of damage;Homologous recombination					6	98					0	0	0.021553	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	65					0	0	0.115264	0	0
MUC16	94025	broad.mit.edu	37	19	9066642	9066642	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:9066642G>A	ENST00000397910.4	-	3	21007	c.20804C>T	c.(20803-20805)tCc>tTc	p.S6935F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6937	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.S6935F(2)|p.S2568F(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTCTCAGAGGAAACAGACAT	0.458000													70	219					0	0	0.139131	0	0
PRIM1	5557	broad.mit.edu	37	12	57128024	57128024	+	Nonsense_Mutation	SNP	T	T	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:57128024T>A	ENST00000338193.6	-	12	1186	c.1150A>T	c.(1150-1152)Aag>Tag	p.K384*		NM_000946.2	NP_000937.1	P49642	PRI1_HUMAN	primase, DNA, polypeptide 1 (49kDa)	384					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	DNA primase activity|metal ion binding	p.K384*(1)		kidney(1)|lung(6)|prostate(1)	8						CTGGTCTTCTTATAATCTAAA	0.323000													6	25					0	0	0.029380	0	0
SLFN12	55106	broad.mit.edu	37	17	33749738	33749738	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr17:33749738G>C	ENST00000394562.1	-	4	833	c.310C>G	c.(310-312)Ctg>Gtg	p.L104V	SLFN12_ENST00000304905.5_Missense_Mutation_p.L104V|SLFN12_ENST00000452764.3_Missense_Mutation_p.L104V			Q8IYM2	SLN12_HUMAN	schlafen family member 12	104							ATP binding	p.L104V(1)		breast(1)|kidney(2)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	18		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ACAAAAATCAGAAAGTAGTTA	0.358000													6	66					0	0	0.021553	0	0
CROT	54677	broad.mit.edu	37	7	86998766	86998766	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr7:86998766G>A	ENST00000331536.3	+	7	807	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K	CROT_ENST00000419147.2_Missense_Mutation_p.E236K|CROT_ENST00000442291.1_Missense_Mutation_p.E208K	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	208					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity	p.E208K(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TGTAATACATGAAGGATGTTT	0.423000													11	150					0	0	0.105934	0	0
PI4KB	5298	broad.mit.edu	37	1	151271344	151271344	+	Missense_Mutation	SNP	T	T	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:151271344T>C	ENST00000368875.2	-	10	2571	c.1991A>G	c.(1990-1992)aAt>aGt	p.N664S	PI4KB_ENST00000529142.1_Missense_Mutation_p.N320S|PI4KB_ENST00000368874.4_Missense_Mutation_p.N637S|PI4KB_ENST00000271657.5_Missense_Mutation_p.N664S|PI4KB_ENST00000368872.1_Missense_Mutation_p.N637S|PI4KB_ENST00000368873.1_Missense_Mutation_p.N652S	NM_002651.2	NP_002642.1	Q9UBF8	PI4KB_HUMAN	phosphatidylinositol 4-kinase, catalytic, beta	652	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding	p.N664S(1)		breast(3)|endometrium(5)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	27	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTGCACAAAATTGCGCTGTGC	0.507000													18	201					0	0	0.160694	0	0
LRP12	29967	broad.mit.edu	37	8	105509340	105509340	+	Silent	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr8:105509340G>A	ENST00000276654.5	-	5	1548	c.1440C>T	c.(1438-1440)agC>agT	p.S480S	LRP12_ENST00000424843.2_Silent_p.S461S	NM_013437.4	NP_038465.1	Q9Y561	LRP12_HUMAN	low density lipoprotein receptor-related protein 12	480	LDL-receptor class A 5.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding	p.S480S(2)		NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TTTCTTCATCGCTGCCATCAC	0.448000													5	89					0	0	0.021553	0	0
ZDHHC15	158866	broad.mit.edu	37	X	74644506	74644506	+	Missense_Mutation	SNP	G	G	C			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chrX:74644506G>C	ENST00000541184.1	-	7	1167	c.690C>G	c.(688-690)agC>agG	p.S230R	ZDHHC15_ENST00000373361.3_3'UTR|ZDHHC15_ENST00000373367.3_Missense_Mutation_p.S239R	NM_001146256.1	NP_001139728.1	Q96MV8	ZDH15_HUMAN	zinc finger, DHHC-type containing 15	239						integral to membrane	zinc ion binding	p.S239R(1)		central_nervous_system(2)|endometrium(3)|large_intestine(5)|liver(1)|lung(11)|ovary(2)|skin(2)	26						TTTTGTTTCTGCTGACAAGCC	0.378000													6	43					0	0	0.047766	0	0
ABCC12	94160	broad.mit.edu	37	16	48145805	48145805	+	Missense_Mutation	SNP	T	T	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr16:48145805T>A	ENST00000311303.3	-	14	2351	c.2006A>T	c.(2005-2007)gAt>gTt	p.D669V	ABCC12_ENST00000416054.1_3'UTR|ABCC12_ENST00000448542.1_Missense_Mutation_p.D669V	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	669	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances	p.D669V(1)		NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				AATAACTTCATCACAAGACTC	0.438000													9	19					0	0	0.069234	0	0
NUP98	4928	broad.mit.edu	37	11	3704561	3704561	+	Missense_Mutation	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr11:3704561G>A	ENST00000324932.7	-	30	5207	c.4787C>T	c.(4786-4788)gCc>gTc	p.A1596V	NUP98_ENST00000359171.4_Missense_Mutation_p.A1522V|NUP98_ENST00000355260.3_Missense_Mutation_p.A1522V	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1613					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity	p.A1596V(1)		NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		GATCCATTTGGCAGGTACACG	0.537000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								22	71					0	0	0.083992	0	0
LILRB2	10288	broad.mit.edu	37	19	54780707	54780707	+	Silent	SNP	G	G	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:54780707G>A	ENST00000391748.1	-	10	1561	c.1434C>T	c.(1432-1434)ctC>ctT	p.L478L	LILRB2_ENST00000434421.1_Silent_p.L363L|LILRB2_ENST00000391749.4_Silent_p.L479L|LILRB2_ENST00000391746.1_Silent_p.L479L|LILRB2_ENST00000314446.5_Silent_p.L478L	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	479					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity	p.L479L(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggatgaggaagaggaggagga	0.607000													4	111					0	0	0.150653	0	0
LRRK2	120892	broad.mit.edu	37	12	40761481	40761481	+	Missense_Mutation	SNP	C	C	G			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:40761481C>G	ENST00000298910.7	+	51	7556	c.7498C>G	c.(7498-7500)Ctt>Gtt	p.L2500V		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2500					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding	p.L2507V(1)|p.L2500V(1)		NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				GGACATCAATCTTCCACATGA	0.303000													3	72					0	0	0.115264	0	0
DAPK1	1612	broad.mit.edu	37	9	90220046	90220046	+	Silent	SNP	C	C	T	rs36207429		TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr9:90220046C>T	ENST00000469640.2	+	3	615	c.240C>T	c.(238-240)caC>caT	p.H80H	DAPK1_ENST00000408954.3_Silent_p.H80H|DAPK1_ENST00000358077.5_Silent_p.H80H|DAPK1_ENST00000472284.1_Silent_p.H80H|DAPK1_ENST00000491893.1_Silent_p.H80H			P53355	DAPK1_HUMAN	death-associated protein kinase 1	80	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity	p.H80H(2)		breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TCACCCTGCACGAGGTCTATG	0.622000									Chronic Lymphocytic Leukemia, Familial Clustering of				12	32					0	0	0.093190	0	0
SETD2	29072	broad.mit.edu	37	3	47103747	47103747	+	Nonsense_Mutation	SNP	T	T	A			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr3:47103747T>A	ENST00000409792.3	-	14	6241	c.6199A>T	c.(6199-6201)Aag>Tag	p.K2067*	SETD2_ENST00000492397.1_5'UTR	NM_014159.6	NP_054878.5	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2067					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding	p.K1564*(1)|p.K2067*(1)		breast(6)|central_nervous_system(5)|endometrium(4)|kidney(63)|large_intestine(18)|lung(26)|ovary(6)|prostate(2)|skin(3)|soft_tissue(1)|stomach(2)|urinary_tract(5)	141		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		TGAGTTTGCTTGTCTGGGTCT	0.478000			"""N, F, S, Mis"""		clear cell renal carcinoma								123	304					0	0	0.139131	0	0
ATF6	22926	broad.mit.edu	37	1	161816357	161816357	+	Frame_Shift_Del	DEL	A	A	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:161816357delA	ENST00000367942.3	+	10	1373	c.1306delA	c.(1306-1308)aafs	p.K436fs	ATF6_ENST00000476437.1_3'UTR	NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	436					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TATTATCCAGAAAAACAGCTA	0.403													42	117	---	---	---	---					
DESI2	51029	broad.mit.edu	37	1	244868886	244868886	+	Frame_Shift_Del	DEL	G	G	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr1:244868886delG	ENST00000302550.11	+	5	759	c.380delG	c.(379-381)tgfs	p.W127fs	DESI2_ENST00000263831.7_Frame_Shift_Del_p.W94fs	NM_016076.3	NP_057160.2	Q9BSY9	PPDE1_HUMAN	desumoylating isopeptidase 2	127	PPPDE peptidase.																ATTCCTCGCTGGATCAATCGA	0.507													8	131	---	---	---	---					
DPY19L2P2	349152	broad.mit.edu	37	7	102883498	102883498	+	RNA	DEL	A	A	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr7:102883498delA	ENST00000312132.4	-	0	2616																											GTACCACTGTAAAAAAAAAAA	0.284													4	6	---	---	---	---					
CC2D2B	387707	broad.mit.edu	37	10	97776014	97776017	+	Frame_Shift_Del	DEL	TTTC	TTTC	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr10:97776014_97776017delTTTC	ENST00000344386.3	+	6	629_632	c.465_468delTTTC	c.(463-468)aafs	p.NF155fs	CC2D2B_ENST00000371198.2_Intron|ENTPD1-AS1_ENST00000452728.1_RNA|RP11-690P14.4_ENST00000475252.2_Intron|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1-AS1_ENST00000454638.1_RNA|ENTPD1-AS1_ENST00000451364.1_RNA|CC2D2B_ENST00000410012.2_Frame_Shift_Del_p.NF155fs	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	155										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		TTCTCTGTAATTTCTTTCTGTATT	0.382													7	69	---	---	---	---					
ACACB	32	broad.mit.edu	37	12	109698333	109698333	+	Frame_Shift_Del	DEL	T	T	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr12:109698333delT	ENST00000338432.7	+	48	6664	c.6545delT	c.(6544-6546)ctfs	p.L2182fs	ACACB_ENST00000377854.5_Frame_Shift_Del_p.L2112fs|ACACB_ENST00000543201.1_3'UTR|ACACB_ENST00000377848.3_Frame_Shift_Del_p.L2182fs			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2182	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GTGGACGGCCTTAGACAATAC	0.552													49	119	---	---	---	---					
APEX1	328	broad.mit.edu	37	14	20925518	20925520	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr14:20925518_20925520delATG	ENST00000216714.3	+	5	1076_1078	c.808_810delATG	c.(808-810)del	p.M271del	APEX1_ENST00000398030.4_In_Frame_Del_p.M271del|APEX1_ENST00000557054.1_3'UTR|APEX1_ENST00000555414.1_In_Frame_Del_p.M271del	NM_001244249.1|NM_001641.3	NP_001231178.1|NP_001632.2	P27695	APEX1_HUMAN	APEX nuclease (multifunctional DNA repair enzyme) 1	271					base-excision repair|DNA demethylation|DNA recombination|positive regulation of anti-apoptosis|positive regulation of DNA repair|regulation of mRNA stability|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|endoplasmic reticulum|mitochondrion|nuclear speck|nucleolus|perinuclear region of cytoplasm|ribosome	3'-5' exonuclease activity|chromatin DNA binding|damaged DNA binding|DNA-(apurinic or apyrimidinic site) lyase activity|metal ion binding|oxidoreductase activity|phosphodiesterase I activity|protein binding|ribonuclease H activity|RNA binding|site-specific endodeoxyribonuclease activity, specific for altered base|transcription coactivator activity|transcription corepressor activity|uracil DNA N-glycosylase activity			breast(2)|endometrium(1)|large_intestine(4)|ovary(2)	9	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)	Lucanthone(DB04967)	TTGGACTTATATGATGAATGCTC	0.502								Other BER factors					51	164	---	---	---	---					
ZNF675	171392	broad.mit.edu	37	19	23845871	23845872	+	Frame_Shift_Ins	INS	-	-	T			TCGA-67-6216-01A-11D-1753-08	TCGA-67-6216-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6dc6da8c-2ecf-412f-b2c4-74529adb7c0f	c76da76a-6d03-4c51-94ed-b333c1be8ca1	g.chr19:23845871_23845872insT	ENST00000359788.4	-	2	260_261	c.92_93insA	c.(91-93)agtfs	p.S31fs	ZNF675_ENST00000601010.1_Frame_Shift_Ins_p.S31fs|ZNF675_ENST00000600313.1_Frame_Shift_Ins_p.S31fs|ZNF675_ENST00000601935.1_Frame_Shift_Ins_p.S31fs|ZNF675_ENST00000599168.1_Frame_Shift_Ins_p.S31fs|ZNF675_ENST00000596211.1_Frame_Shift_Ins_p.S31fs	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	31	KRAB.				bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CTAAAATCACATTTTTATATAA	0.386													7	189	---	---	---	---					
