Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DACH1	1602	broad.mit.edu	37	13	72440289	72440289	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:72440289C>A	ENST00000305425.4	-	1	1041	c.619G>T	c.(619-621)Ggc>Tgc	p.G207C	DACH1_ENST00000313174.7_Missense_Mutation_p.G207C|DACH1_ENST00000359684.2_Missense_Mutation_p.G207C|DACH1_ENST00000354591.4_Missense_Mutation_p.G207C	NM_080759.4	NP_542937.2	Q9UI36	DACH1_HUMAN	dachshund homolog 1 (Drosophila)	205	DACHbox-N.|Interaction with SIX6 and HDAC3 (By similarity).				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		AGCTCGCAGCCCTCCACCGTG	0.577000													10	43					4.3838e-07	5.28012e-07	0.435327	1	0
WT1	7490	broad.mit.edu	37	11	32413520	32413520	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:32413520G>T	ENST00000332351.3	-	9	1714	c.1430C>A	c.(1429-1431)aCa>aAa	p.T477K	WT1_ENST00000379079.2_Intron|WT1_ENST00000448076.3_Intron|WT1_ENST00000530998.1_Missense_Mutation_p.T248K	NM_024424.3|NM_024426.4	NP_077742.2|NP_077744.3	P19544	WT1_HUMAN	Wilms tumor 1	409					adrenal cortex formation|branching involved in ureteric bud morphogenesis|camera-type eye development|cardiac muscle cell fate commitment|cellular response to cAMP|cellular response to gonadotropin stimulus|germ cell development|glomerular basement membrane development|glomerular visceral epithelial cell differentiation|induction of apoptosis|male genitalia development|male gonad development|mesenchymal to epithelial transition|metanephric epithelium development|metanephric S-shaped body morphogenesis|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of female gonad development|negative regulation of metanephric glomerular mesangial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of translation|positive regulation of male gonad development|positive regulation of transcription, DNA-dependent|posterior mesonephric tubule development|regulation of organ formation|RNA splicing|sex determination|vasculogenesis|visceral serous pericardium development	cytoplasm|nuclear speck|nucleoplasm	C2H2 zinc finger domain binding|RNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V380_S410del(1)	EWSR1/WT1(234)	NS(1)|haematopoietic_and_lymphoid_tissue(348)|kidney(149)|large_intestine(9)|lung(20)|peritoneum(1)|pleura(2)|skin(2)|upper_aerodigestive_tract(1)	533	Breast(20;0.247)		OV - Ovarian serous cystadenocarcinoma(30;0.128)			TTACGCACTTGTTTTACCTGT	0.383000			"""D, Mis, N, F, S"""	EWSR1	"""Wilms, desmoplastic small round cell tumor"""	Wilms			Wilms' tumor-Aniridia-ambiguous Genitals-mental Retardation;Frasier syndrome;Familial Wilms' tumor;Denys-Drash syndrome				56	153					3.28615e-30	6.37553e-30	0.870114	1	0
NEBL	10529	broad.mit.edu	37	10	21461395	21461395	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:21461395T>A	ENST00000417816.2	-	2	434	c.81A>T	c.(79-81)aaA>aaT	p.K27N	NEBL_ENST00000464278.1_5'UTR	NM_001173484.1|NM_213569.2	NP_001166955.1|NP_998734.1	O76041	NEBL_HUMAN	nebulette	0					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGAAACATCCTTTATGCCAAT	0.383000													9	31					0	0	0.411799	0	0
WDR36	134430	broad.mit.edu	37	5	110446893	110446893	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:110446893T>A	ENST00000506538.2	+	15	2373	c.1800T>A	c.(1798-1800)gaT>gaA	p.D600E	WDR36_ENST00000505303.1_Missense_Mutation_p.D544E|WDR36_ENST00000513710.2_Missense_Mutation_p.D600E	NM_139281.2	NP_644810.1	Q8NI36	WDR36_HUMAN	WD repeat domain 36	600					response to stimulus|rRNA processing|visual perception	small-subunit processome				cervix(1)|endometrium(9)|kidney(4)|large_intestine(11)|lung(13)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TCGCCTTGGATGACTTCTCCA	0.378000													60	194					0	0	0.870114	0	0
ZNF286B	729288	broad.mit.edu	37	17	18565820	18565820	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr17:18565820C>A	ENST00000545289.1	-	5	1249	c.999G>T	c.(997-999)ggG>ggT	p.G333G		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	333					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						TAAAACCTTTCCCACATTCAT	0.383000													12	39					8.28177e-16	1.24227e-15	0.557998	1	0
NBAS	51594	broad.mit.edu	37	2	15378592	15378592	+	Splice_Site	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:15378592C>G	ENST00000281513.5	-	45	5968	c.5943_splice	c.e45+1	p.Q1981_splice	NBAS_ENST00000441750.1_Splice_Site_p.Q1861_splice	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1981										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						ATTTCTTTACCTGCTCACTAT	0.393000													11	23					0	0	0.387290	0	0
DICER1	23405	broad.mit.edu	37	14	95570155	95570155	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:95570155T>C	ENST00000526495.1	-	23	3869	c.3578A>G	c.(3577-3579)aAc>aGc	p.N1193S	DICER1_ENST00000527414.1_Missense_Mutation_p.N1193S|DICER1_ENST00000541352.1_Missense_Mutation_p.N1193S|DICER1_ENST00000393063.1_Missense_Mutation_p.N1193S|DICER1_ENST00000556045.1_Missense_Mutation_p.N91S|DICER1_ENST00000343455.3_Missense_Mutation_p.N1193S			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1193					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		AAAGTCTCTGTTAGCTAAATC	0.393000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				63	72					0	0	0.870114	0	0
PARD3B	117583	broad.mit.edu	37	2	206166215	206166215	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:206166215C>G	ENST00000406610.2	+	18	2627	c.2420C>G	c.(2419-2421)tCt>tGt	p.S807C	PARD3B_ENST00000358768.2_Missense_Mutation_p.S745C|PARD3B_ENST00000462231.1_Missense_Mutation_p.S807C|PARD3B_ENST00000351153.1_Missense_Mutation_p.S738C|PARD3B_ENST00000349953.3_Missense_Mutation_p.S807C	NM_057177.6|NM_152526.5|NM_205863.3	NP_476518.4|NP_689739.4|NP_995585.2	Q8TEW8	PAR3L_HUMAN	par-3 family cell polarity regulator beta	807					cell cycle|cell division	endomembrane system|tight junction				breast(1)|endometrium(9)|kidney(2)|large_intestine(6)|liver(4)|lung(33)|ovary(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)	65		all_cancers(1;2.88e-06)|all_epithelial(1;3.23e-06)		Epithelial(149;0.0739)		AGCTCTCACTCTGGCCAAGGA	0.448000													29	71					0	0	0.796494	0	0
SULF1	23213	broad.mit.edu	37	8	70512970	70512970	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:70512970G>T	ENST00000260128.4	+	9	1584	c.867G>T	c.(865-867)gtG>gtT	p.V289V	SULF1_ENST00000521946.1_3'UTR|SULF1_ENST00000402687.4_Silent_p.V289V|SULF1_ENST00000458141.2_Silent_p.V289V|SULF1_ENST00000419716.3_Silent_p.V289V	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	289					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TGATGTCAGTGGATGATTCTG	0.438000													80	92					1.82171e-49	3.80797e-49	0.870114	1	0
ACSM2B	348158	broad.mit.edu	37	16	20566619	20566619	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:20566619C>A	ENST00000329697.6	-	4	736	c.568G>T	c.(568-570)Ggg>Tgg	p.G190W	ACSM2B_ENST00000414188.2_Missense_Mutation_p.G190W|ACSM2B_ENST00000567001.1_Missense_Mutation_p.G190W|ACSM2B_ENST00000565232.1_Missense_Mutation_p.G190W|ACSM2B_ENST00000565322.1_Missense_Mutation_p.G111W	NM_001105069.1	NP_001098539.1	Q68CK6	ACS2B_HUMAN	acyl-CoA synthetase medium-chain family member 2B	190					fatty acid metabolic process|xenobiotic metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|CoA-ligase activity|metal ion binding			breast(4)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(33)|ovary(1)|prostate(1)|skin(5)	57						TTCAGCCACCCATCGCAGCTT	0.443000													70	198					3.82636e-28	7.16613e-28	0.870114	1	0
KCNMB1	3779	broad.mit.edu	37	5	169812331	169812331	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:169812331G>A	ENST00000274629.4	-	2	563	c.121C>T	c.(121-123)Ctc>Ttc	p.L41F	KCNMB1_ENST00000521859.1_Missense_Mutation_p.L41F|KCNIP1_ENST00000518527.1_Intron|KCNIP1_ENST00000377360.4_Intron	NM_004137.3	NP_004128.1	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 1	41					platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			endometrium(1)|large_intestine(1)|lung(7)|ovary(2)	11	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		TTCTGGTAGAGGGGCAGCACA	0.602000													53	51					0	0	0.870114	0	0
DNPEP	23549	broad.mit.edu	37	2	220251451	220251451	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:220251451C>A	ENST00000273075.4	-	4	489	c.269G>T	c.(268-270)gGc>gTc	p.G90V	DNPEP_ENST00000523282.1_Missense_Mutation_p.G98V|DNPEP_ENST00000373972.1_Missense_Mutation_p.G15V	NM_012100.2	NP_036232.2	Q9ULA0	DNPEP_HUMAN	aspartyl aminopeptidase	80					peptide metabolic process|proteolysis	cytoplasm	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Renal(207;0.0474)		Epithelial(149;1.09e-06)|all cancers(144;0.000179)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)	L-Glutamic Acid(DB00142)	AACGTACTGGCCCCCTACAGC	0.582000													8	10					7.48243e-07	8.88025e-07	0.335167	1	0
ZNF622	90441	broad.mit.edu	37	5	16465729	16465729	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:16465729C>G	ENST00000308683.2	-	1	172	c.46G>C	c.(46-48)Gcg>Ccg	p.A16P		NM_033414.2	NP_219482.1	Q969S3	ZN622_HUMAN	zinc finger protein 622	16						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						TGCATGTCCGCGTCGCGGAAC	0.632000													14	66					0	0	0.500413	0	0
CCDC89	220388	broad.mit.edu	37	11	85396673	85396673	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:85396673C>A	ENST00000316398.3	-	1	647	c.501G>T	c.(499-501)caG>caT	p.Q167H		NM_152723.1	NP_689936.1	Q8N998	CCD89_HUMAN	coiled-coil domain containing 89	167						cytoplasm|nucleus				NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	15		Acute lymphoblastic leukemia(157;4.88e-06)|all_hematologic(158;0.00572)				CCTTCAGAGCCTGGCTGAAGA	0.527000													51	56					4.6707e-30	8.95448e-30	0.870114	1	0
MICAL2	9645	broad.mit.edu	37	11	12183740	12183740	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:12183740G>A	ENST00000256194.4	+	3	326	c.38G>A	c.(37-39)gGg>gAg	p.G13E	MICAL2_ENST00000527546.1_Missense_Mutation_p.G13E|MICAL2_ENST00000379612.3_Missense_Mutation_p.G13E|MICAL2_ENST00000537344.1_Missense_Mutation_p.G13E|MICAL2_ENST00000342902.5_Missense_Mutation_p.G13E	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2	13						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding	p.G13V(1)		breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		GCCCAGGCGGGGCAGGTTTTT	0.572000													11	43					0	0	0.435327	0	0
ZNF519	162655	broad.mit.edu	37	18	14105256	14105256	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr18:14105256C>A	ENST00000590202.1	-	3	1435	c.1283G>T	c.(1282-1284)gGa>gTa	p.G428V	ZNF519_ENST00000589203.1_Intron|ZNF519_ENST00000589498.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						GTGTTTCTCTCCAGTATGGAT	0.408000													33	48					1.57351e-24	2.81668e-24	0.788014	1	0
ADCY10	55811	broad.mit.edu	37	1	167825589	167825589	+	Missense_Mutation	SNP	C	C	A	rs148745290		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:167825589C>A	ENST00000367848.1	-	17	2206	c.1709G>T	c.(1708-1710)cGg>cTg	p.R570L	ADCY10_ENST00000545172.1_Missense_Mutation_p.R509L|ADCY10_ENST00000367851.4_Missense_Mutation_p.R662L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	662					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						AGGAAGAGTCCGGATAAGCTT	0.443000													84	132					6.42612e-47	1.33466e-46	0.870114	1	0
ZNF286B	729288	broad.mit.edu	37	17	18565821	18565821	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr17:18565821C>A	ENST00000545289.1	-	5	1248	c.998G>T	c.(997-999)gGg>gTg	p.G333V		NM_001145045.1	NP_001138517.1	P0CG31	Z286B_HUMAN	zinc finger protein 286B	333					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(1)	2						AAAACCTTTCCCACATTCATT	0.388000													12	40					8.28177e-16	1.24227e-15	0.557998	1	0
AFF4	27125	broad.mit.edu	37	5	132234013	132234013	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:132234013C>T	ENST00000265343.5	-	10	1677	c.1298G>A	c.(1297-1299)gGa>gAa	p.G433E	AFF4_ENST00000378595.3_Missense_Mutation_p.G433E	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	433	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GCTTTCAGATCCACTGTGGCT	0.453000													31	50					0	0	0.769981	0	0
ERG	2078	broad.mit.edu	37	21	39775583	39775583	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr21:39775583G>A	ENST00000442448.1	-	6	729	c.458C>T	c.(457-459)gCg>gTg	p.A153V	ERG_ENST00000398910.1_Missense_Mutation_p.A153V|ERG_ENST00000398919.2_Missense_Mutation_p.A153V|ERG_ENST00000417133.2_Missense_Mutation_p.A153V|ERG_ENST00000398897.1_Missense_Mutation_p.A54V|ERG_ENST00000453032.2_Missense_Mutation_p.A54V|ERG_ENST00000288319.7_Missense_Mutation_p.A146V|ERG_ENST00000398907.1_Missense_Mutation_p.A146V|ERG_ENST00000398905.1_Missense_Mutation_p.A146V|ERG_ENST00000429727.2_Intron|ERG_ENST00000398911.1_Missense_Mutation_p.A153V	NM_004449.4	NP_004440.1	P11308	ERG_HUMAN	v-ets avian erythroblastosis virus E26 oncogene homolog	153	PNT.				cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		EWSR1/ERG(178)|NDRG1/ERG(5)|TMPRSS2/ERG(3582)|FUS/ERG(167)|SLC45A3/ERG(50)	lung(2)|ovary(1)|skin(1)	4		Prostate(19;3.6e-06)				TTCTTTCACCGCCCACTCCAG	0.507000			T	"""EWSR1, TMPRSS2, ELF4, FUS, HERPUD1, NDRG1"""	"""Ewing sarcoma, prostate, AML"""								19	52					0	0	0.624587	0	0
ANK2	287	broad.mit.edu	37	4	114276041	114276041	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:114276041C>A	ENST00000357077.4	+	38	6320	c.6267C>A	c.(6265-6267)agC>agA	p.S2089R	ANK2_ENST00000394537.3_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.S2056R|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000506722.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2056					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AAGTTCTCAGCCACAAAATAC	0.488000													10	27					4.68919e-08	5.7768e-08	0.361761	1	0
SLAMF9	89886	broad.mit.edu	37	1	159921514	159921514	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:159921514C>T	ENST00000368093.3	-	4	923	c.807G>A	c.(805-807)aaG>aaA	p.K269K	SLAMF9_ENST00000368092.3_Silent_p.K178K|SLAMF9_ENST00000466773.1_5'UTR	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	269						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCATGAGTTTCTTCATCCTTG	0.507000													56	75					0	0	0.870114	0	0
VSX1	30813	broad.mit.edu	37	20	25056959	25056959	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr20:25056959G>T	ENST00000376709.4	-	5	1299	c.1036C>A	c.(1036-1038)Caa>Aaa	p.Q346K	VSX1_ENST00000429762.3_Intron|VSX1_ENST00000451258.1_Intron|VSX1_ENST00000444511.2_Intron|VSX1_ENST00000424574.1_Intron	NM_014588.5	NP_055403.2	Q9NZR4	VSX1_HUMAN	visual system homeobox 1	346					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(3)|lung(2)	6						GAGCCTCCTTGAGCACCAGCC	0.587000													13	29					0.00185496	0.00193873	0.435327	1	0
ZNF99	7652	broad.mit.edu	37	19	22939928	22939928	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:22939928G>T	ENST00000397104.3	-	6	2402	c.2403C>A	c.(2401-2403)ccC>ccA	p.P801P						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CACATTTGTAGGGCTTCTCCC	0.378000													24	53					1.33986e-20	2.28482e-20	0.681144	1	0
TMEM169	92691	broad.mit.edu	37	2	216964791	216964791	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:216964791G>C	ENST00000454545.1	+	4	746	c.420G>C	c.(418-420)agG>agC	p.R140S	TMEM169_ENST00000437356.2_Missense_Mutation_p.R140S|TMEM169_ENST00000295658.4_Missense_Mutation_p.R140S|TMEM169_ENST00000406027.2_Missense_Mutation_p.R140S	NM_001142310.1	NP_001135782.1	Q96HH4	TM169_HUMAN	transmembrane protein 169	140						integral to membrane				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(2)	13		Renal(323;0.0651)		Epithelial(149;6.44e-06)|all cancers(144;0.000398)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGTCATCAAGGGAAACGACGC	0.537000													10	20					0	0	0.361761	0	0
OR5B2	390190	broad.mit.edu	37	11	58189955	58189955	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:58189955G>T	ENST00000302581.2	-	1	831	c.780C>A	c.(778-780)ccC>ccA	p.P260P		NM_001005566.2	NP_001005566.1	Q96R09	OR5B2_HUMAN	olfactory receptor, family 5, subfamily B, member 2	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGCTGGAGCTGGGCTGCAAGT	0.498000													14	40					9.16793e-09	1.14688e-08	0.520397	1	0
BBC3	27113	broad.mit.edu	37	19	47725050	47725050	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:47725050T>C	ENST00000449228.1	-	4	857	c.694A>G	c.(694-696)Acc>Gcc	p.T232A	BBC3_ENST00000300880.7_Missense_Mutation_p.T72A|BBC3_ENST00000439096.2_3'UTR|BBC3_ENST00000341983.4_3'UTR	NM_001127240.2	NP_001120712.1	Q9BXH1	BBC3_HUMAN	BCL2 binding component 3	0					activation of caspase activity|activation of pro-apoptotic gene products|cellular response to hypoxia|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of growth|positive regulation of protein homooligomerization|positive regulation of release of cytochrome c from mitochondria|positive regulation of thymocyte apoptosis|protein insertion into mitochondrial membrane involved in induction of apoptosis|reduction of endoplasmic reticulum calcium ion concentration|release of cytochrome c from mitochondria|release of sequestered calcium ion into cytosol	cytosol|mitochondrial outer membrane	protein binding			endometrium(1)|lung(2)|skin(1)	4		all_cancers(25;1.13e-05)|all_lung(116;0.000192)|all_epithelial(76;0.000274)|Lung NSC(112;0.000446)|all_neural(266;0.0652)|Ovarian(192;0.15)		all cancers(93;0.000179)|OV - Ovarian serous cystadenocarcinoma(262;0.00029)|Epithelial(262;0.0103)|GBM - Glioblastoma multiforme(486;0.0234)		ACCGGGCGGGTGCAGGCACCT	0.662000													9	10					0	0	0.335167	0	0
SPEN	23013	broad.mit.edu	37	1	16256929	16256929	+	Missense_Mutation	SNP	A	A	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:16256929A>C	ENST00000375759.3	+	11	4398	c.4194A>C	c.(4192-4194)ttA>ttC	p.L1398F		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1398					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCTCTGCATTATATGAAAGTT	0.423000													10	30					0	0	0.387290	0	0
PRPF40A	55660	broad.mit.edu	37	2	153519186	153519186	+	Silent	SNP	T	T	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:153519186T>C	ENST00000410080.1	-	21	2794	c.2253A>G	c.(2251-2253)ccA>ccG	p.P751P		NM_017892.3	NP_060362.3	O75400	PR40A_HUMAN	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	778	FF 5.				mRNA processing|RNA splicing	nuclear matrix|nuclear speck	protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|urinary_tract(1)	21						CCTCAAATGCTGGCTCTTTTA	0.269000													7	11					0	0	0.361761	0	0
TRIM51	84767	broad.mit.edu	37	11	55655703	55655703	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:55655703C>A	ENST00000449290.2	+	4	795	c.703C>A	c.(703-705)Caa>Aaa	p.Q235K	TRIM51_ENST00000244891.3_Missense_Mutation_p.Q92K	NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	235						intracellular	zinc ion binding										GGATCTGAAGCAAATGTGCCA	0.448000													6	58					0.000157383	0.000169409	0.278610	1	0
ERBB4	2066	broad.mit.edu	37	2	212589909	212589909	+	Silent	SNP	C	C	T	rs142765774	by1000genomes	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:212589909C>T	ENST00000342788.4	-	6	943	c.633G>A	c.(631-633)acG>acA	p.T211T	ERBB4_ENST00000484474.1_5'UTR|ERBB4_ENST00000402597.1_Silent_p.T211T|ERBB4_ENST00000436443.1_Silent_p.T211T	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	211	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.T211T(1)		NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CTGCACACACCGTCCTTGTCA	0.512000										TSP Lung(8;0.080)			27	86					0	0	0.769981	0	0
REG1P	5969	broad.mit.edu	37	2	79364190	79364190	+	RNA	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:79364190T>A	ENST00000444841.1	-	0	285																											CCAGCATCTCTGTGCTGAATG	0.463000													4	5					0	0	0.150653	0	0
NCAM1	4684	broad.mit.edu	37	11	113075033	113075033	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:113075033C>A	ENST00000316851.7	+	2	123	c.123C>A	c.(121-123)gaC>gaA	p.D41E	NCAM1_ENST00000533760.1_5'UTR|NCAM1_ENST00000401611.2_Missense_Mutation_p.D50E|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	51	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		AAGATAAAGACATCTCCTGGT	0.468000													5	12					0.184627	0.186353	0.184627	1	0
REG1P	5969	broad.mit.edu	37	2	79364189	79364189	+	RNA	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:79364189C>A	ENST00000444841.1	-	0	285																											ACCAGCATCTCTGTGCTGAAT	0.468000													4	5					0.00909568	0.00935556	0.150653	1	0
GALNT2	2590	broad.mit.edu	37	1	230371838	230371838	+	Silent	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:230371838C>G	ENST00000366672.4	+	4	525	c.453C>G	c.(451-453)gcC>gcG	p.A151A	GALNT2_ENST00000543760.1_Silent_p.A113A|GALNT2_ENST00000541865.1_Silent_p.A61A	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	151	Catalytic subdomain A.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				CCAGGTCGGCCCTACTCAGGA	0.582000													11	39					0	0	0.457914	0	0
CCDC136	64753	broad.mit.edu	37	7	128446765	128446765	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:128446765G>T	ENST00000297788.4	+	9	1639	c.1272G>T	c.(1270-1272)aaG>aaT	p.K424N	CCDC136_ENST00000464832.1_Intron|CCDC136_ENST00000378685.4_Intron|CCDC136_ENST00000487361.1_Missense_Mutation_p.K371N	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	424						integral to membrane	protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						GGCTGCAGAAGCTGCACCTCC	0.572000													7	9					1.12685e-05	1.26771e-05	0.307466	1	0
COL6A2	1292	broad.mit.edu	37	21	47546150	47546150	+	Splice_Site	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr21:47546150G>A	ENST00000300527.4	+	26	2525	c.2422_splice	c.e26+1	p.P807_splice	COL6A2_ENST00000397763.1_Splice_Site_p.P807_splice|COL6A2_ENST00000310645.5_Splice_Site_p.P807_splice|COL6A2_ENST00000357838.4_Splice_Site_p.P807_splice|COL6A2_ENST00000409416.1_Splice_Site_p.P807_splice	NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	807	Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		TCCTCTGCCCGGGTGAGCGTG	0.652000													59	82					0	0	0.870114	0	0
COL22A1	169044	broad.mit.edu	37	8	139890388	139890388	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:139890388G>T	ENST00000303045.6	-	3	709	c.263C>A	c.(262-264)aCg>aAg	p.T88K	COL22A1_ENST00000435777.1_Missense_Mutation_p.T88K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	88	VWFA.				cell adhesion	collagen|cytoplasm	structural molecule activity	p.T88M(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CTCGAAGGCCGTGGTGGGCCG	0.697000										HNSCC(7;0.00092)			7	5					2.17888e-05	2.41766e-05	0.335167	1	0
GSG1L	146395	broad.mit.edu	37	16	27840252	27840252	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:27840252A>G	ENST00000380898.2	-	5	772	c.223T>C	c.(223-225)Tgc>Cgc	p.C75R	GSG1L_ENST00000447459.2_Missense_Mutation_p.C230R|GSG1L_ENST00000569166.1_Missense_Mutation_p.C75R|GSG1L_ENST00000380897.3_Missense_Mutation_p.C75R|GSG1L_ENST00000395724.3_Missense_Mutation_p.C179R			Q6UXU4	GSG1L_HUMAN	GSG1-like	230	Ala-rich.					integral to membrane				endometrium(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(4)	17						GCTGCCATGCAGCAGGTAAAG	0.582000													14	30					0	0	0.539581	0	0
FTHL17	53940	broad.mit.edu	37	X	31090017	31090017	+	Missense_Mutation	SNP	G	G	T	rs145075121		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:31090017G>T	ENST00000359202.3	-	1	153	c.54C>A	c.(52-54)gaC>gaA	p.D18E		NM_031894.2	NP_114100.1	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	18	Ferritin-like diiron.				cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	23						TGATGGCGGCGTCGCAGTTGG	0.642000													28	42					3.73148e-12	5.2112e-12	0.717897	1	0
OVCH1	341350	broad.mit.edu	37	12	29608325	29608325	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:29608325C>A	ENST00000318184.5	-	20	2293	c.2294G>T	c.(2293-2295)gGg>gTg	p.G765V	OVCH1-AS1_ENST00000551108.1_Intron|OVCH1-AS1_ENST00000549411.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	765	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					TACTAGTGGCCCACCAGAGTC	0.453000													18	41					4.35082e-09	5.5065e-09	0.592651	1	0
SLIT2	9353	broad.mit.edu	37	4	20618585	20618585	+	Missense_Mutation	SNP	C	C	G	rs141395818		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:20618585C>G	ENST00000504154.1	+	35	4152	c.3900C>G	c.(3898-3900)aaC>aaG	p.N1300K	SLIT2_ENST00000503837.1_Missense_Mutation_p.N1296K|SLIT2_ENST00000273739.5_Missense_Mutation_p.N1313K|SLIT2_ENST00000503823.1_Missense_Mutation_p.N1292K	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1300	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						CTGGGCAGAACGGAACCAGCT	0.582000													6	32					0	0	0.278610	0	0
DHX37	57647	broad.mit.edu	37	12	125449541	125449541	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:125449541C>T	ENST00000308736.2	-	14	1845	c.1747G>A	c.(1747-1749)Gat>Aat	p.D583N	DHX37_ENST00000544745.1_Missense_Mutation_p.D370N	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	583	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		AGGGAGGCATCCGGCTGCTCA	0.682000													6	8					0	0	0.278610	0	0
ITPR3	3710	broad.mit.edu	37	6	33634974	33634974	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:33634974G>T	ENST00000374316.5	+	16	2680	c.1620G>T	c.(1618-1620)gaG>gaT	p.E540D	ITPR3_ENST00000605930.1_Missense_Mutation_p.E540D			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	540					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GGCTGGAGGAGCTGTCAGACC	0.617000													31	52					4.66903e-05	5.11069e-05	0.750413	1	0
SORCS1	114815	broad.mit.edu	37	10	108437095	108437095	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:108437095G>T	ENST00000263054.6	-	13	1815	c.1808C>A	c.(1807-1809)aCa>aAa	p.T603K	SORCS1_ENST00000369698.1_Missense_Mutation_p.T138K|SORCS1_ENST00000344440.6_Missense_Mutation_p.T603K	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	603						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TGGGAGAGATGTGTGTTTCAT	0.458000													10	60					9.31168e-06	1.05489e-05	0.435327	1	0
CRB1	23418	broad.mit.edu	37	1	197298112	197298112	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:197298112A>G	ENST00000367400.3	+	2	766	c.631A>G	c.(631-633)Atc>Gtc	p.I211V	CRB1_ENST00000538660.1_Missense_Mutation_p.I211V|CRB1_ENST00000535699.1_Missense_Mutation_p.I142V|CRB1_ENST00000367399.2_Missense_Mutation_p.I211V	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	211	EGF-like 5; calcium-binding (Potential).				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATATACTTGTATCTGTCCCCA	0.413000													3	56					0	0	0.150653	0	0
RCN3	57333	broad.mit.edu	37	19	50040445	50040445	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:50040445C>T	ENST00000270645.3	+	4	1048	c.601C>T	c.(601-603)Cgg>Tgg	p.R201W		NM_020650.2	NP_065701.2	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	201	EF-hand 4.					endoplasmic reticulum lumen	calcium ion binding|protein binding	p.R201W(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		CCCTCACATGCGGGACATCGT	0.662000													64	124					0	0	0.870114	0	0
KCNJ4	3761	broad.mit.edu	37	22	38824099	38824099	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr22:38824099G>T	ENST00000303592.3	-	2	297	c.39C>A	c.(37-39)ccC>ccA	p.P13P		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	13					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					GCTTCCGCCGGGGCACGTGGG	0.647000													113	144					4.13896e-67	8.76485e-67	0.870114	1	0
GOT1	2805	broad.mit.edu	37	10	101163362	101163362	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:101163362C>A	ENST00000370508.5	-	7	850	c.823G>T	c.(823-825)Gga>Tga	p.G275*	GOT1_ENST00000543866.1_Nonsense_Mutation_p.G254*	NM_002079.2	NP_002070.1	P17174	AATC_HUMAN	glutamic-oxaloacetic transaminase 1, soluble	275					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|prostate(2)	16		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	GGTTCTTTTCCAACCACAGTC	0.547000													51	85					6.81593e-30	1.29904e-29	0.870114	1	0
OR5M3	219482	broad.mit.edu	37	11	56237922	56237922	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:56237922G>A	ENST00000312240.2	-	1	92	c.52C>T	c.(52-54)Cgt>Tgt	p.R18C		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					CATTCTCGACGGCTCGTTAGC	0.398000													6	74					0	0	0.248553	0	0
NCK2	8440	broad.mit.edu	37	2	106497870	106497870	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:106497870G>A	ENST00000233154.4	+	4	755	c.313G>A	c.(313-315)Ggc>Agc	p.G105S	NCK2_ENST00000522586.1_Intron|NCK2_ENST00000393349.2_Missense_Mutation_p.G105S|NCK2_ENST00000451463.2_Intron	NM_003581.4	NP_003572.2	O43639	NCK2_HUMAN	NCK adaptor protein 2	105					axon guidance|epidermal growth factor receptor signaling pathway|negative regulation of cell proliferation|positive regulation of actin filament polymerization|positive regulation of T cell proliferation|regulation of epidermal growth factor receptor activity|regulation of translation|signal complex assembly|T cell activation	cytosol|endoplasmic reticulum	cytoskeletal adaptor activity|receptor signaling complex scaffold activity			endometrium(1)|lung(3)|ovary(1)	5						CAATGGCAGCGGCGCCGACCG	0.677000													20	33					0	0	0.592651	0	0
EMILIN3	90187	broad.mit.edu	37	20	39989942	39989942	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr20:39989942A>T	ENST00000332312.3	-	4	2459	c.2267T>A	c.(2266-2268)cTg>cAg	p.L756Q		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	756						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				CTGCTCAGCCAGCTGGGCCTG	0.657000													9	33					0	0	0.361761	0	0
AMER2	219287	broad.mit.edu	37	13	25744312	25744312	+	Silent	SNP	G	G	T	rs139238510		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:25744312G>T	ENST00000357816.2	-	3	1564	c.1089C>A	c.(1087-1089)gcC>gcA	p.A363A	AMER2_ENST00000381853.3_Silent_p.A363A|AMER2_ENST00000515384.1_Silent_p.A482A					APC membrane recruitment protein 2																		ACGCGTCCTTGGCCGCTTCCA	0.657000													8	18					0.000157383	0.000169409	0.278610	1	0
GRHL2	79977	broad.mit.edu	37	8	102656358	102656358	+	Splice_Site	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:102656358G>T	ENST00000251808.3	+	13	1855		c.e13-1		GRHL2_ENST00000517674.1_Splice_Site|GRHL2_ENST00000395927.1_Splice_Site	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)							cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			ATCTTTTCTAGTGGCAGTGTC	0.453000													4	30					1.23904e-05	1.3891e-05	0.184627	1	0
CAMTA1	23261	broad.mit.edu	37	1	7724662	7724662	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:7724662G>T	ENST00000303635.7	+	9	2262	c.2055G>T	c.(2053-2055)acG>acT	p.T685T	CAMTA1_ENST00000439411.2_Silent_p.T685T	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	685					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGGCCATGACGGCAGAAGGGG	0.637000			T	WWTR1	epitheliod hemangioendothelioma								8	60					0.0477658	0.0485144	0.307466	1	0
ITGA4	3676	broad.mit.edu	37	2	182344947	182344947	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:182344947G>T	ENST00000397033.2	+	6	1138	c.708G>T	c.(706-708)aaG>aaT	p.K236N		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	236					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	ATAAATACAAGGCTTTTTTAG	0.303000													13	35					5.50884e-06	6.26268e-06	0.411799	1	0
SUCLG2	8801	broad.mit.edu	37	3	67578634	67578634	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:67578634C>A	ENST00000307227.5	-	4	366	c.339G>T	c.(337-339)gtG>gtT	p.V113V	SUCLG2_ENST00000493112.1_Silent_p.V113V|SUCLG2_ENST00000492795.1_Silent_p.V113V	NM_003848.3	NP_003839.2	Q96I99	SUCB2_HUMAN	succinate-CoA ligase, GDP-forming, beta subunit	113	ATP-grasp.				succinyl-CoA metabolic process|tricarboxylic acid cycle	mitochondrial matrix	ATP binding|GTP binding|succinate-CoA ligase (GDP-forming) activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	10		Renal(2;0.00294)|Lung NSC(201;0.012)|Hepatocellular(537;0.121)		BRCA - Breast invasive adenocarcinoma(55;3.53e-05)|Epithelial(33;0.000153)	Succinic acid(DB00139)	CCAGCTGTCCCACAACATTAG	0.378000													9	26					9.70103e-10	1.27252e-09	0.361761	1	0
CHL1	10752	broad.mit.edu	37	3	391201	391201	+	Silent	SNP	T	T	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:391201T>G	ENST00000256509.2	+	10	1650	c.1008T>G	c.(1006-1008)acT>acG	p.T336T	CHL1_ENST00000397491.2_Silent_p.T320T	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	320	Ig-like C2-type 4.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		GAACAGCCACTCACGATTTTC	0.393000													24	85					0	0	0.769981	0	0
FLT1	2321	broad.mit.edu	37	13	28893609	28893609	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:28893609C>A	ENST00000282397.4	-	24	3488	c.3237G>T	c.(3235-3237)aaG>aaT	p.K1079N	FLT1_ENST00000540678.1_Missense_Mutation_p.K297N|FLT1_ENST00000543394.1_Missense_Mutation_p.K102N	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	1079	Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	ACACGTCGCTCTTGGTGCTGT	0.463000													7	19					5.18039e-06	5.91002e-06	0.278610	1	0
AMER3	205147	broad.mit.edu	37	2	131519752	131519752	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:131519752C>A	ENST00000423981.1	+	2	217	c.107C>A	c.(106-108)cCc>cAc	p.P36H	AMER3_ENST00000321420.4_Missense_Mutation_p.P36H	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		GGGACAGGCCCCTGGTCAGTC	0.622000													7	7					0.00198382	0.002047	0.248553	1	0
GAL3ST4	79690	broad.mit.edu	37	7	99764351	99764351	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:99764351C>A	ENST00000360039.4	-	3	595	c.203G>T	c.(202-204)cGa>cTa	p.R68L	GAL3ST4_ENST00000411994.1_Intron|GAL3ST4_ENST00000423751.1_Intron|GAL3ST4_ENST00000413800.1_Missense_Mutation_p.R68L|GAL3ST4_ENST00000426974.2_Intron|GAL3ST4_ENST00000482469.1_5'UTR	NM_024637.4	NP_078913.3	Q96RP7	G3ST4_HUMAN	galactose-3-O-sulfotransferase 4	68					cell-cell signaling|oligosaccharide metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane|membrane fraction	3'-phosphoadenosine 5'-phosphosulfate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|ovary(5)|prostate(1)|upper_aerodigestive_tract(1)	26	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GAACACCAGTCGCTGCCGGGG	0.657000													5	19					0.00116845	0.00122517	0.217242	1	0
FAT1	2195	broad.mit.edu	37	4	187540236	187540236	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:187540236C>T	ENST00000441802.2	-	10	7713	c.7504G>A	c.(7504-7506)Gct>Act	p.A2502T		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2502	Cadherin 23.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GCGTTTTCAGCTAGTTCCACT	0.423000										HNSCC(5;0.00058)			52	151					0	0	0.870114	0	0
COL4A5	1287	broad.mit.edu	37	X	107920744	107920744	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:107920744G>T	ENST00000328300.6	+	44	4067	c.3823G>T	c.(3823-3825)Gaa>Taa	p.E1275*	COL4A5_ENST00000361603.2_Nonsense_Mutation_p.E1269*	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	1269	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						ACCAGGTCCAGAAGGTCCTCC	0.443000									Alport syndrome with Diffuse Leiomyomatosis				34	28					3.38236e-24	5.98844e-24	0.827153	1	0
ZEB1	6935	broad.mit.edu	37	10	31799619	31799619	+	Nonsense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:31799619C>G	ENST00000446923.2	+	5	843	c.452C>G	c.(451-453)tCa>tGa	p.S151*	ZEB1_ENST00000542815.3_Nonsense_Mutation_p.S100*|ZEB1_ENST00000320985.10_Nonsense_Mutation_p.S167*|ZEB1_ENST00000361642.5_Nonsense_Mutation_p.S168*|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000560721.2_Nonsense_Mutation_p.S147*	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	167					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				GATGCATTTTCACAATTACTC	0.313000													38	36					0	0	0.859065	0	0
EFCAB6	64800	broad.mit.edu	37	22	44161271	44161271	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr22:44161271G>T	ENST00000262726.7	-	5	607	c.354C>A	c.(352-354)atC>atA	p.I118I	EFCAB6_ENST00000356087.4_Silent_p.I12I|EFCAB6_ENST00000358439.4_Silent_p.I12I|EFCAB6_ENST00000396231.2_5'UTR	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TGCTAAGGGGGATCTACAGTC	0.408000													16	102					2.4624e-09	3.14101e-09	0.575678	1	0
ABCB5	340273	broad.mit.edu	37	7	20689721	20689721	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:20689721G>T	ENST00000404938.2	+	12	1935	c.1283G>T	c.(1282-1284)aGt>aTt	p.S428I	ABCB5_ENST00000258738.6_5'UTR|ABCB5_ENST00000477094.1_3'UTR|ABCB5_ENST00000443026.2_5'UTR|ABCB5_ENST00000406935.1_5'UTR	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	612	ABC transmembrane type-1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						AGTGGGAAGAGTACGGTAGTC	0.458000													22	28					1.5548e-18	2.48155e-18	0.693898	1	0
SLC15A1	6564	broad.mit.edu	37	13	99356551	99356551	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:99356551A>G	ENST00000376503.5	-	17	1463	c.1408T>C	c.(1408-1410)Tac>Cac	p.Y470H		NM_005073.3	NP_005064.1	P46059	S15A1_HUMAN	solute carrier family 15 (oligopeptide transporter), member 1	470					digestion|protein transport	integral to plasma membrane|membrane fraction	peptide:hydrogen symporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	30	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Cefadroxil(DB01140)|Ceftibuten(DB01415)|Cyclacillin(DB01000)	ACCACCTGGTAGTGATTGGGG	0.458000													15	78					0	0	0.539581	0	0
PAGE5	90737	broad.mit.edu	37	X	55247075	55247075	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:55247075A>T	ENST00000289619.5	+	1	288	c.43A>T	c.(43-45)Agg>Tgg	p.R15W	PAGE5_ENST00000374952.1_Intron|PAGE5_ENST00000374955.3_Intron	NM_130467.3	NP_569734.2	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 (prostate associated)	15										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						GGCTGGAACGAGGGAGGAAGG	0.642000													6	13					0	0	0.248553	0	0
DOC2A	8448	broad.mit.edu	37	16	30017977	30017977	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:30017977G>T	ENST00000350119.4	-	9	1090	c.900C>A	c.(898-900)gaC>gaA	p.D300E	DOC2A_ENST00000564979.1_Missense_Mutation_p.D300E|DOC2A_ENST00000564944.1_Missense_Mutation_p.D300E	NM_003586.2	NP_003577.2	Q14183	DOC2A_HUMAN	double C2-like domains, alpha	300	C2 2.|Interaction with UNC13D.				nervous system development|regulation of calcium ion-dependent exocytosis	cell junction|lysosome|synaptic vesicle membrane|synaptosome	calcium-dependent phospholipid binding|protein binding|transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(2)	9						TGGATTTCTTGTCCACATCGG	0.607000													34	61					9.9191e-30	1.87941e-29	0.840704	1	0
XIRP2	129446	broad.mit.edu	37	2	168104682	168104682	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:168104682C>A	ENST00000409195.1	+	9	6869	c.6780C>A	c.(6778-6780)tcC>tcA	p.S2260S	XIRP2_ENST00000295237.9_Silent_p.S2260S|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409273.1_Silent_p.S2038S	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2085					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CAAATACTTCCACAGGCTTAA	0.393000													32	46					2.42023e-17	3.73407e-17	0.779181	1	0
OR14C36	127066	broad.mit.edu	37	1	248512625	248512625	+	Silent	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:248512625G>A	ENST00000317861.1	+	1	549	c.549G>A	c.(547-549)ctG>ctA	p.L183L		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						CCTCTCTGCTGAAGCTCTCTT	0.498000													44	57					0	0	0.870114	0	0
FAM9B	171483	broad.mit.edu	37	X	9000187	9000187	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:9000187C>A	ENST00000362066.3	-	3	488	c.300G>T	c.(298-300)aaG>aaT	p.K100N	FAM9B_ENST00000327220.5_Missense_Mutation_p.K55N|FAM9B_ENST00000428477.1_Missense_Mutation_p.K55N			Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	55						nucleus				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|urinary_tract(1)	11		Hepatocellular(5;0.219)				TATCTTCTGGCTTCTTGGTAT	0.318000													14	26					4.7546e-09	5.9709e-09	0.500413	1	0
CHD5	26038	broad.mit.edu	37	1	6173025	6173025	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:6173025T>C	ENST00000262450.3	-	34	5045	c.4946A>G	c.(4945-4947)gAc>gGc	p.D1649G	CHD5_ENST00000378021.1_Missense_Mutation_p.D506G	NM_015557.2	NP_056372.1	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	1649					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			breast(3)|central_nervous_system(3)|liver(1)|lung(1)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	16	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		CTCCAGCTTGTCCAGGATCTT	0.577000													19	39					0	0	0.667858	0	0
TMC3	342125	broad.mit.edu	37	15	81627114	81627114	+	Silent	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr15:81627114A>T	ENST00000558726.1	-	21	2544	c.2409T>A	c.(2407-2409)ccT>ccA	p.P803P	RP11-761I4.3_ENST00000559781.1_RNA|RP11-761I4.3_ENST00000560851.1_RNA|RP11-761I4.3_ENST00000560973.1_RNA|TMC3_ENST00000359440.5_Silent_p.P802P			Q7Z5M5	TMC3_HUMAN	transmembrane channel-like 3	802						integral to membrane				autonomic_ganglia(2)|breast(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	34						GAGGTGAGCTAGGAGCCCTGT	0.567000													6	20					0	0	0.217242	0	0
PALM	5064	broad.mit.edu	37	19	726187	726187	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:726187G>T	ENST00000264560.7	+	2	249	c.55G>T	c.(55-57)Gca>Tca	p.A19S	PALM_ENST00000606643.1_3'UTR|PALM_ENST00000338448.5_Missense_Mutation_p.A19S	NM_001040134.1	NP_001035224.1	O75781	PALM_HUMAN	paralemmin	19					cellular component movement|negative regulation of adenylate cyclase activity|negative regulation of dopamine receptor signaling pathway|positive regulation of filopodium assembly|regulation of cell shape	cytoplasmic membrane-bounded vesicle|filopodium membrane|integral to plasma membrane				endometrium(2)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_epithelial(18;2.19e-21)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)|Lung(535;0.201)		GCAGGCCATCGCAGTGAGTTT	0.677000													25	23					6.07407e-21	1.04127e-20	0.717897	1	0
ZNF605	100289635	broad.mit.edu	37	12	133502051	133502051	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:133502051T>C	ENST00000360187.4	-	5	2182	c.1834A>G	c.(1834-1836)Aca>Gca	p.T612A	ZNF605_ENST00000392321.3_Missense_Mutation_p.T643A	NM_183238.3	NP_899061.1	Q86T29	ZN605_HUMAN	zinc finger protein 605	612					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(16)|large_intestine(5)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	28	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00227)|all_epithelial(31;0.142)		OV - Ovarian serous cystadenocarcinoma(86;9.24e-09)|Epithelial(86;2.11e-07)|all cancers(50;5.27e-06)		TTATCTCCTGTATGAATCCTC	0.378000													28	68					0	0	0.779181	0	0
NUPL1	9818	broad.mit.edu	37	13	25895081	25895081	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:25895081A>T	ENST00000463407.1	+	9	944	c.801A>T	c.(799-801)caA>caT	p.Q267H	NUPL1_ENST00000466694.1_3'UTR|NUPL1_ENST00000381718.3_Missense_Mutation_p.Q255H|NUPL1_ENST00000381736.3_Missense_Mutation_p.Q267H			Q9BVL2	NUPL1_HUMAN	nucleoporin like 1	267	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|stomach(1)|urinary_tract(1)	16		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		AGCAGAAACAAGTTCAAGAAG	0.303000													12	10					0	0	0.411799	0	0
ADAMTS12	81792	broad.mit.edu	37	5	33637732	33637732	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:33637732G>T	ENST00000504830.1	-	12	2173	c.1838C>A	c.(1837-1839)aCt>aAt	p.T613N	ADAMTS12_ENST00000504582.1_5'UTR|ADAMTS12_ENST00000352040.3_Missense_Mutation_p.T613N	NM_030955.2	NP_112217.2	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 12	613	Cys-rich.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(7)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(31)|liver(1)|lung(135)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	216						GTAGGGAACAGTGTCAAATTC	0.468000										HNSCC(64;0.19)			45	87					1.48341e-19	2.45217e-19	0.870114	1	0
HIRIP3	8479	broad.mit.edu	37	16	30005266	30005266	+	Silent	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:30005266A>T	ENST00000279392.3	-	4	2030	c.1200T>A	c.(1198-1200)tcT>tcA	p.S400S	HIRIP3_ENST00000564026.1_Intron	NM_003609.4	NP_003600.2	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	400	Poly-Ser.				chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(9)	17						CTGAGGAGGAAGAGGAGCTTC	0.622000													18	27					0	0	0.624587	0	0
TNXB	7148	broad.mit.edu	37	6	32011571	32011571	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:32011571G>T	ENST00000375244.3	-	35	11686	c.11485C>A	c.(11485-11487)Cga>Aga	p.R3829R	TNXB_ENST00000451343.1_Silent_p.R258R|TNXB_ENST00000375247.2_Silent_p.R3827R			P22105	TENX_HUMAN	tenascin XB	3874	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCAAAGCCTCGGACCGAGACC	0.637000													43	74					1.8453e-21	3.1972e-21	0.853193	1	0
ZFP69B	65243	broad.mit.edu	37	1	40923036	40923036	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:40923036G>C	ENST00000411995.2	+	5	736	c.361G>C	c.(361-363)Ggc>Cgc	p.G121R	ZFP69B_ENST00000361584.3_Missense_Mutation_p.G19R|ZFP69B_ENST00000484445.1_Missense_Mutation_p.W92S	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B																		TTCCAAACCTGGCGTGATTTC	0.458000													17	30					0	0	0.608945	0	0
XKR7	343702	broad.mit.edu	37	20	30584749	30584749	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr20:30584749C>A	ENST00000217299.3	+	3	1403	c.1229C>A	c.(1228-1230)aCc>aAc	p.T410N		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	410						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AACTTCTCAACCGACTTCTAC	0.602000													8	43					0.000274275	0.000291361	0.307466	1	0
POU4F1	5457	broad.mit.edu	37	13	79176020	79176020	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:79176020C>A	ENST00000377208.5	-	2	1001	c.790G>T	c.(790-792)Gac>Tac	p.D264Y	RNF219-AS1_ENST00000607220.1_RNA|RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000430549.2_RNA|RNF219-AS1_ENST00000607860.1_RNA|RNF219-AS1_ENST00000607205.1_RNA|RNF219-AS1_ENST00000606429.1_RNA|RNF219-AS1_ENST00000606124.1_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000606376.1_RNA|RNF219-AS1_ENST00000444769.3_RNA	NM_006237.3	NP_006228.3	Q01851	PO4F1_HUMAN	POU class 4 homeobox 1	264	POU-specific.				axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(5)|ovary(1)	16		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		TCGCGCGGGTCCGTGTCCGAG	0.766000													3	3					0.000602214	0.000635562	0.184627	1	0
YLPM1	56252	broad.mit.edu	37	14	75230646	75230646	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:75230646G>T	ENST00000325680.7	+	1	578	c.454G>T	c.(454-456)Gtg>Ttg	p.V152L	YLPM1_ENST00000552421.1_Missense_Mutation_p.V152L|YLPM1_ENST00000238571.3_Missense_Mutation_p.V152L	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	152	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		ATCTCCCCCTGTGCCGCCTGG	0.607000													17	38					3.52763e-06	4.08197e-06	0.520397	1	0
DCDC1	341019	broad.mit.edu	37	11	30938525	30938525	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:30938525G>T	ENST00000597505.1	-	24	3343	c.3344C>A	c.(3343-3345)cCc>cAc	p.P1115H	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Missense_Mutation_p.P194H			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GGCATACCTGGGAAGTGTGTG	0.423000													31	75					6.5261e-18	1.02644e-17	0.840704	1	0
PTPRN	5798	broad.mit.edu	37	2	220156202	220156202	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:220156202C>A	ENST00000295718.2	-	20	2959	c.2719G>T	c.(2719-2721)Gtg>Ttg	p.V907L	PTPRN_ENST00000423636.2_Missense_Mutation_p.V817L|PTPRN_ENST00000409251.3_Missense_Mutation_p.V878L|PTPRN_ENST00000497977.1_5'UTR	NM_002846.3	NP_002837.1	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	907	Tyrosine-protein phosphatase.				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(3)|prostate(4)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CTGCAGTGCACGATGATGGGG	0.592000													20	55					7.01153e-11	9.46557e-11	0.717897	1	0
FAM3D	131177	broad.mit.edu	37	3	58620041	58620041	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:58620041C>G	ENST00000358781.2	-	10	950	c.640G>C	c.(640-642)Gag>Cag	p.E214Q	RP11-475O23.3_ENST00000464125.1_RNA	NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	214					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CCCTCCATCTCCAGCAGCTCT	0.537000													20	60					0	0	0.654019	0	0
ZNF808	388558	broad.mit.edu	37	19	53050786	53050786	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:53050786G>T	ENST00000359798.4	+	4	265	c.85G>T	c.(85-87)Gtg>Ttg	p.V29L		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	29	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TTTCAGGGATGTGGCTATAGA	0.428000													45	83					6.34439e-16	9.60553e-16	0.870114	1	0
MUC16	94025	broad.mit.edu	37	19	9067164	9067164	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:9067164C>A	ENST00000397910.4	-	3	20485	c.20282G>T	c.(20281-20283)aGg>aTg	p.R6761M		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6763	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTTCCTGCCCTGGAGGATGT	0.478000													87	87					4.98208e-43	1.01522e-42	0.870114	1	0
CDH12	1010	broad.mit.edu	37	5	21802310	21802310	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:21802310C>A	ENST00000382254.1	-	10	2308	c.1222G>T	c.(1222-1224)Gct>Tct	p.A408S	CDH12_ENST00000521384.1_5'UTR|CDH12_ENST00000504376.2_Missense_Mutation_p.A408S|CDH12_ENST00000522262.1_Missense_Mutation_p.A368S	NM_004061.3	NP_004052.2	P55289	CAD12_HUMAN	cadherin 12, type 2 (N-cadherin 2)	408	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(19)|lung(75)|ovary(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	120						AGGTCTTGAGCAGTGACAGCG	0.458000										HNSCC(59;0.17)			19	27					1.37657e-19	2.28722e-19	0.608945	1	0
ITIH6	347365	broad.mit.edu	37	X	54785081	54785081	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:54785081C>A	ENST00000218436.6	-	8	1455	c.1426G>T	c.(1426-1428)Gat>Tat	p.D476Y		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	476					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										AGACGCACATCTGCCAGCAGA	0.592000													16	23					1.33834e-09	1.72757e-09	0.557998	1	0
PIK3R5	23533	broad.mit.edu	37	17	8790490	8790490	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr17:8790490A>T	ENST00000447110.1	-	12	1952	c.1828T>A	c.(1828-1830)Tac>Aac	p.Y610N	PIK3R5_ENST00000581552.1_Missense_Mutation_p.Y610N|PIK3R5_ENST00000584803.1_Missense_Mutation_p.Y610N	NM_001142633.2|NM_001251851.1|NM_001251852.1|NM_001251853.1|NM_001251855.1	NP_001136105.1|NP_001238780.1|NP_001238781.1|NP_001238782.1|NP_001238784.1	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	610					platelet activation	cytosol|membrane|nucleus				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(14)|prostate(3)|skin(4)|urinary_tract(1)	34						ATGCCGAGGTAGTGGGAGATG	0.612000													11	57					0	0	0.411799	0	0
MYT1L	23040	broad.mit.edu	37	2	1906868	1906868	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:1906868G>T	ENST00000399161.2	-	14	2763	c.2016C>A	c.(2014-2016)ccC>ccA	p.P672P	MYT1L_ENST00000428368.2_Silent_p.P670P	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	672					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CATATCCTTTGGGGGATATAT	0.418000													24	59					4.15321e-07	5.0588e-07	0.740014	1	0
COL26A1	136227	broad.mit.edu	37	7	101183182	101183182	+	RNA	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:101183182G>T	ENST00000313669.7	+	0	648				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		AGGTCCTCCTGCTAGAAGCAG	0.622000													8	30					1.58986e-06	1.85962e-06	0.361761	1	0
CDK8	1024	broad.mit.edu	37	13	26975642	26975642	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:26975642G>T	ENST00000381527.3	+	12	1653	c.1150G>T	c.(1150-1152)Gga>Tga	p.G384*	CDK8_ENST00000480323.1_3'UTR|CDK8_ENST00000536792.1_3'UTR	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CCACACTAATGGAACTGGCCA	0.478000													15	20					1.3612e-06	1.60374e-06	0.479597	1	0
TTLL4	9654	broad.mit.edu	37	2	219614034	219614034	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:219614034C>T	ENST00000392102.1	+	14	2999	c.2659C>T	c.(2659-2661)Cat>Tat	p.H887Y	TTLL4_ENST00000258398.4_Missense_Mutation_p.H887Y|TTLL4_ENST00000457313.1_Missense_Mutation_p.H722Y|TTLL4_ENST00000442769.1_Missense_Mutation_p.H823Y	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	887	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CTATAGCTGCCATGAACTCTT	0.517000													29	39					0	0	0.750413	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77325276	77325276	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr15:77325276C>A	ENST00000558012.1	+	12	1401	c.912C>A	c.(910-912)tcC>tcA	p.S304S	PSTPIP1_ENST00000557995.1_3'UTR|PSTPIP1_ENST00000379595.3_Silent_p.S304S|PSTPIP1_ENST00000267939.5_Intron|PSTPIP1_ENST00000559295.1_Intron	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	304					cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						TACAGCCGTCCTGCGGCATGA	0.652000													6	7					3.09899e-07	3.78895e-07	0.307466	1	0
PCDHB7	56129	broad.mit.edu	37	5	140553781	140553781	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:140553781C>T	ENST00000231137.3	+	1	1539	c.1365C>T	c.(1363-1365)tcC>tcT	p.S455S		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		455					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCAAACCTCCTACACCCTGT	0.602000													52	93					0	0	0.870114	0	0
DYRK4	8798	broad.mit.edu	37	12	4708299	4708299	+	Silent	SNP	G	G	A	rs138577409	byFrequency	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:4708299G>A	ENST00000540757.2	+	7	826	c.666G>A	c.(664-666)tcG>tcA	p.S222S	DYRK4_ENST00000010132.5_Silent_p.S222S|DYRK4_ENST00000543431.1_Silent_p.S222S	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	222	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			AGATGCTTTCGGTAGAGAAAA	0.463000													16	90					0	0	0.575678	0	0
POTEH	23784	broad.mit.edu	37	22	16287673	16287673	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr22:16287673C>G	ENST00000343518.6	-	1	264	c.213G>C	c.(211-213)tgG>tgC	p.W71C		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	71								p.W71C(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TCCCCCTGCACCAGGGGAAGC	0.582000													5	222					0	0	0.435327	0	0
CLPTM1	1209	broad.mit.edu	37	19	45477801	45477801	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:45477801G>T	ENST00000541297.2	+	4	838	c.373G>T	c.(373-375)Ggc>Tgc	p.G125C	CLPTM1_ENST00000546079.1_Missense_Mutation_p.G37C|CLPTM1_ENST00000337392.5_Missense_Mutation_p.G139C			O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane protein 1	139					cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		CTGGACTAGCGGCGAGAACTC	0.572000													22	42					2.79863e-10	3.76248e-10	0.681144	1	0
OR4K1	79544	broad.mit.edu	37	14	20404272	20404272	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:20404272G>T	ENST00000285600.4	+	1	506	c.447G>T	c.(445-447)tgG>tgT	p.W149C		NM_001004063.2	NP_001004063.2	Q8NGD4	OR4K1_HUMAN	olfactory receptor, family 4, subfamily K, member 1	149					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(24)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTATTTCCTGGGCGGTGGGCG	0.458000													32	57					2.85442e-18	4.51137e-18	0.750413	1	0
ULK4	54986	broad.mit.edu	37	3	41949337	41949337	+	Splice_Site	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:41949337C>A	ENST00000301831.4	-	12	1644	c.1182_splice	c.e12+1	p.K394_splice	ULK4_ENST00000420927.1_Splice_Site_p.K394_splice	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	394							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GTCTGCTCACCTTGGTCAGAG	0.388000													6	40					5.18039e-06	5.91002e-06	0.278610	1	0
TBX5	6910	broad.mit.edu	37	12	114793838	114793838	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:114793838G>T	ENST00000310346.4	-	9	1722	c.1056C>A	c.(1054-1056)tcC>tcA	p.S352S	TBX5_ENST00000349716.5_Silent_p.S302S|TBX5_ENST00000405440.2_Silent_p.S352S	NM_000192.3	NP_000183.2	Q99593	TBX5_HUMAN	T-box 5	352					cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(29)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		AGCGGTAGAAGGAATCTTCTT	0.552000													43	96					2.74695e-27	5.05689e-27	0.870114	1	0
ANKRD36BP1	84832	broad.mit.edu	37	1	168215939	168215939	+	RNA	SNP	A	A	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:168215939A>G	ENST00000358576.4	-	0	642					NR_026844.1															lung(1)	1						CTACGATGGTATGATTCCATT	0.423000													9	12					0	0	0.307466	0	0
ZFPM2	23414	broad.mit.edu	37	8	106814044	106814044	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:106814044G>T	ENST00000407775.2	+	8	1984	c.1734G>T	c.(1732-1734)atG>atT	p.M578I	ZFPM2_ENST00000378472.4_Missense_Mutation_p.M309I|ZFPM2_ENST00000517361.1_Missense_Mutation_p.M446I|RP11-152P17.2_ENST00000520433.1_RNA|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|RP11-152P17.2_ENST00000518932.1_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.M446I	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	578					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			GGCAGCAGATGGCTAAGTCCC	0.453000													83	97					1.26289e-39	2.54147e-39	0.870114	1	0
RBM19	9904	broad.mit.edu	37	12	114380154	114380154	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:114380154C>A	ENST00000545145.2	-	14	1790	c.1712G>T	c.(1711-1713)gGg>gTg	p.G571V	RBM19_ENST00000261741.5_Missense_Mutation_p.G571V|RBM19_ENST00000392561.3_Missense_Mutation_p.G571V	NM_001146699.1	NP_001140171.1	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	571					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					CAGGCTGACCCCGTTGTCTAT	0.622000													9	31					3.86212e-05	4.24179e-05	0.361761	1	0
SACS	26278	broad.mit.edu	37	13	23909311	23909311	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:23909311C>A	ENST00000382298.3	-	10	9292	c.8704G>T	c.(8704-8706)Gga>Tga	p.G2902*	SACS_ENST00000402364.1_Nonsense_Mutation_p.G2152*|SACS_ENST00000382292.3_Nonsense_Mutation_p.G2902*	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	2902					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ACACCAACTCCATTATCATCA	0.418000													15	50					6.72482e-11	9.1165e-11	0.479597	1	0
SLC7A14	57709	broad.mit.edu	37	3	170198557	170198557	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:170198557T>A	ENST00000231706.4	-	7	1829	c.1514A>T	c.(1513-1515)aAc>aTc	p.N505I	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	505						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			GTGGTTGACGTTGTAGGTTGA	0.468000													113	78					0	0	0.870114	0	0
SASH1	23328	broad.mit.edu	37	6	148865380	148865380	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:148865380C>G	ENST00000367467.3	+	18	3249	c.2774C>G	c.(2773-2775)cCt>cGt	p.P925R		NM_015278.3	NP_056093.3	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	925							protein binding			breast(4)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		CTGTCACCCCCTCAGTGTTTG	0.512000													15	29					0	0	0.479597	0	0
PKD1L2	114780	broad.mit.edu	37	16	81253874	81253874	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:81253874G>T	ENST00000599697.1	-	1	101	c.102C>A	c.(100-102)gcC>gcA	p.A34A	PKD1L2_ENST00000337114.4_RNA|PKD1L2_ENST00000525539.1_RNA			Q7Z442	PK1L2_HUMAN	polycystic kidney disease 1-like 2	34					neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						CATCTCTGAAGGCCACCTGGC	0.562000													17	58					6.94344e-10	9.18235e-10	0.539581	1	0
TTC29	83894	broad.mit.edu	37	4	147724697	147724697	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:147724697G>T	ENST00000513335.1	-	12	1519	c.1320C>A	c.(1318-1320)aaC>aaA	p.N440K	TTC29_ENST00000506019.1_5'UTR|TTC29_ENST00000398886.4_Missense_Mutation_p.N440K|TTC29_ENST00000325106.4_Missense_Mutation_p.N414K			Q8NA56	TTC29_HUMAN	tetratricopeptide repeat domain 29	414							binding			breast(2)|cervix(2)|endometrium(3)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	26	all_hematologic(180;0.151)					ACTCTATATAGTTGTTCACTG	0.438000													4	6					0.00198382	0.002047	0.248553	1	0
CUBN	8029	broad.mit.edu	37	10	16962128	16962128	+	Missense_Mutation	SNP	C	C	A	rs146703141		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:16962128C>A	ENST00000377833.4	-	44	6720	c.6655G>T	c.(6655-6657)Ggc>Tgc	p.G2219C		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	2219	CUB 16.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TAGACGTTGCCCCCACAGGCT	0.478000													8	38					0.000274275	0.000291361	0.307466	1	0
YJEFN3	374887	broad.mit.edu	37	19	19645898	19645898	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:19645898G>T	ENST00000555938.1	+	5	383	c.371G>T	c.(370-372)gGc>gTc	p.G124V	YJEFN3_ENST00000436027.4_Missense_Mutation_p.G75V|YJEFN3_ENST00000514277.3_Missense_Mutation_p.G125V																							GTCGTGTGTGGCCCGGAGCAG	0.647000													92	156					5.11573e-52	1.0763e-51	0.870114	1	0
PCDH9	5101	broad.mit.edu	37	13	67205545	67205545	+	Splice_Site	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:67205545T>A	ENST00000544246.1	-	4	3830		c.e4-2		PCDH9_ENST00000456367.1_Splice_Site|PCDH9_ENST00000377865.2_Splice_Site|PCDH9_ENST00000328454.5_Splice_Site	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9						homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GCGCTGCGACTACAAAGAAGA	0.478000													6	12					0	0	0.217242	0	0
CDH23	64072	broad.mit.edu	37	10	73567647	73567647	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:73567647C>T	ENST00000224721.6	+	59	8625	c.8620C>T	c.(8620-8622)Ctg>Ttg	p.L2874L	CDH23_ENST00000475158.1_3'UTR|CDH23_ENST00000398788.3_Silent_p.L629L	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2869	Cadherin 27.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GATCCAGGTGCTGGCCCTGGA	0.607000													3	6					0	0	0.150653	0	0
CD34	947	broad.mit.edu	37	1	208061141	208061141	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:208061141G>T	ENST00000310833.7	-	8	1421	c.1100C>A	c.(1099-1101)gCc>gAc	p.A367D	CD34_ENST00000485761.1_Intron|CD34_ENST00000537704.1_Missense_Mutation_p.A232D|CD34_ENST00000356522.4_3'UTR|CD34_ENST00000367036.3_Missense_Mutation_p.A209D	NM_001025109.1	NP_001020280.1	P28906	CD34_HUMAN	CD34 molecule	367			A -> S (in dbSNP:rs28362497).		cell-cell adhesion|leukocyte migration|regulation of immune response	integral to membrane	carbohydrate binding			kidney(2)|large_intestine(2)|lung(8)|ovary(1)	13						TCTGGAGGTGGCCTGGCCGGT	0.622000													34	110					3.21399e-22	5.59857e-22	0.804634	1	0
ITGAX	3687	broad.mit.edu	37	16	31383064	31383064	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:31383064G>C	ENST00000268296.4	+	17	2240	c.2119G>C	c.(2119-2121)Ggg>Cgg	p.G707R	ITGAX_ENST00000562522.1_Missense_Mutation_p.G707R	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	707					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						CCGAGTCCTCGGGCTGAAGGC	0.652000													17	43					0	0	0.557998	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719188	140719188	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:140719188G>T	ENST00000394576.2	+	1	650	c.650G>T	c.(649-651)gGg>gTg	p.G217V	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTCTGATGGGGGTGACCCA	0.587000													11	67					0.0692343	0.0700997	0.361761	1	0
GRM3	2913	broad.mit.edu	37	7	86415619	86415619	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:86415619T>A	ENST00000361669.2	+	3	1610	c.511T>A	c.(511-513)Tac>Aac	p.Y171N	AC005009.2_ENST00000452471.1_RNA|AC005009.2_ENST00000418031.1_RNA|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000536043.1_Missense_Mutation_p.Y43N|GRM3_ENST00000439827.1_Missense_Mutation_p.Y171N|GRM3_ENST00000394720.2_Missense_Mutation_p.Y169N	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	171					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	TCAGATCAGCTACGCATCCAC	0.552000													61	91					0	0	0.870114	0	0
GDF2	2658	broad.mit.edu	37	10	48416617	48416617	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:48416617T>A	ENST00000249598.1	-	1	236	c.77A>T	c.(76-78)cAg>cTg	p.Q26L		NM_016204.1	NP_057288.1	Q9UK05	GDF2_HUMAN	growth differentiation factor 2	26					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|endometrium(2)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	28						TCCCCAGCTCTGCAGTGGCTT	0.652000													8	13					0	0	0.361761	0	0
PAGE1	8712	broad.mit.edu	37	X	49458770	49458770	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:49458770G>A	ENST00000376150.3	-	3	230	c.98C>T	c.(97-99)tCa>tTa	p.S33L		NM_003785.3	NP_003776.2	O75459	GAGB1_HUMAN	P antigen family, member 1 (prostate associated)	33					cellular defense response					endometrium(1)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	7	Ovarian(276;0.236)					TTGAGTTGGTGATTCCACTTC	0.448000													4	14					0	0	0.184627	0	0
IGKV1-16	28938	broad.mit.edu	37	2	89399501	89399501	+	RNA	SNP	A	A	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:89399501A>G	ENST00000479981.1	-	0	228																											TAGATCAGGGACTTAGGGGCT	0.512000													23	106					0	0	0.760397	0	0
NLRP5	126206	broad.mit.edu	37	19	56539106	56539106	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:56539106G>A	ENST00000390649.3	+	7	1507	c.1507G>A	c.(1507-1509)Gcc>Acc	p.A503T		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	503	NACHT.					mitochondrion|nucleolus	ATP binding	p.A503T(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		AGGCCTGCACGCCGCTTTTGT	0.632000													15	19					0	0	0.457914	0	0
PDE10A	10846	broad.mit.edu	37	6	165957053	165957053	+	Nonsense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:165957053A>T	ENST00000366882.1	-	3	195	c.41T>A	c.(40-42)tTg>tAg	p.L14*	PDE10A_ENST00000354448.4_Nonsense_Mutation_p.L14*|PDE10A_ENST00000539869.2_Nonsense_Mutation_p.L24*			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	14					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TTCATCTGTCAAACCTGTAAA	0.358000													3	11					0	0	0.115264	0	0
TRIM35	23087	broad.mit.edu	37	8	27151801	27151801	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:27151801C>A	ENST00000305364.4	-	3	641	c.558G>T	c.(556-558)cgG>cgT	p.R186R	TRIM35_ENST00000521253.1_Silent_p.R154R	NM_171982.3	NP_741983.2	Q9UPQ4	TRI35_HUMAN	tripartite motif containing 35	186					apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding			breast(1)|endometrium(6)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	14		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		CCTGCCGGATCCGGCCTTCCA	0.562000													19	44					7.87624e-14	1.14951e-13	0.639603	1	0
DNAH9	1770	broad.mit.edu	37	17	11651071	11651071	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr17:11651071G>T	ENST00000262442.3	+	32	6666	c.6598G>T	c.(6598-6600)Gaa>Taa	p.E2200*	DNAH9_ENST00000454412.2_Nonsense_Mutation_p.E2200*	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2200	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		AGCCACAGGAGAATGGAAGGA	0.522000													21	52					3.83957e-06	4.42712e-06	0.639603	1	0
STON2	85439	broad.mit.edu	37	14	81743579	81743579	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:81743579C>T	ENST00000555447.1	-	6	2488	c.2076G>A	c.(2074-2076)acG>acA	p.T692T	STON2_ENST00000267540.2_Silent_p.T692T	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	692	MHD.				endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CACTTGTGGCCGTCCTGAGTG	0.562000													71	108					0	0	0.870114	0	0
SLC4A11	83959	broad.mit.edu	37	20	3208951	3208951	+	Missense_Mutation	SNP	T	T	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr20:3208951T>C	ENST00000380059.3	-	19	2742	c.2641A>G	c.(2641-2643)Atg>Gtg	p.M881V	SLC4A11_ENST00000380056.3_Missense_Mutation_p.M854V|SLC4A11_ENST00000474451.1_5'UTR|SLC4A11_ENST00000539553.1_Missense_Mutation_p.M838V	NM_001174090.1	NP_001167561.1	Q8NBS3	S4A11_HUMAN	solute carrier family 4, sodium borate transporter, member 11	854	Membrane (bicarbonate transporter).				cellular cation homeostasis|fluid transport|phosphoenolpyruvate-dependent sugar phosphotransferase system	basolateral plasma membrane|integral to membrane	bicarbonate transmembrane transporter activity|borate transmembrane transporter activity|hydrogen ion channel activity|inorganic anion exchanger activity|sodium channel activity|sugar:hydrogen symporter activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(4)|soft_tissue(1)|urinary_tract(1)	40						ATCATCTTCATGTAGGGCAGG	0.607000													16	60					0	0	0.557998	0	0
ITPR2	3709	broad.mit.edu	37	12	26750046	26750046	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:26750046C>A	ENST00000381340.3	-	31	4440	c.4024G>T	c.(4024-4026)Gtg>Ttg	p.V1342L		NM_002223.2	NP_002214.2	Q14571	ITPR2_HUMAN	inositol 1,4,5-trisphosphate receptor, type 2	1342					activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity		ETV6/ITPR2(2)	biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(20)|liver(1)|lung(51)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	125	Colorectal(261;0.0847)					AATATCAGCACGTCTTCACCC	0.418000													53	128					1.84395e-34	3.6879e-34	0.870114	1	0
DPY19L3	147991	broad.mit.edu	37	19	32902151	32902151	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:32902151C>T	ENST00000342179.5	+	3	325	c.110C>T	c.(109-111)aCc>aTc	p.T37I	DPY19L3_ENST00000587077.1_Missense_Mutation_p.T37I|DPY19L3_ENST00000586987.1_Missense_Mutation_p.T37I|DPY19L3_ENST00000392250.2_Missense_Mutation_p.T37I	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	37						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					AAAGGTTGTACCAGTAGAAGA	0.348000													18	37					0	0	0.539581	0	0
POTEA	340441	broad.mit.edu	37	8	43172496	43172496	+	RNA	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:43172496G>A	ENST00000522175.2	+	0	839							Q6S8J7	POTEA_HUMAN	POTE ankyrin domain family, member A											breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(27)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						TGCATCTGCAGAAAGTGACTC	0.299000													35	61					0	0	0.827153	0	0
CREB3L2	64764	broad.mit.edu	37	7	137569837	137569837	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:137569837C>G	ENST00000330387.6	-	10	1525	c.1174G>C	c.(1174-1176)Ggc>Cgc	p.G392R	CREB3L2_ENST00000456390.1_Missense_Mutation_p.G392R	NM_194071.3	NP_919047.2	Q70SY1	CR3L2_HUMAN	cAMP responsive element binding protein 3-like 2	392					chondrocyte differentiation|positive regulation of transcription, DNA-dependent|response to endoplasmic reticulum stress|response to unfolded protein	endoplasmic reticulum membrane|integral to membrane|nucleus	cAMP response element binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		FUS/CREB3L2(158)	breast(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						AAGAAGCTGCCGAATGCAACG	0.582000			T	FUS	fibromyxoid sarcoma								12	29					0	0	0.435327	0	0
BOD1L1	259282	broad.mit.edu	37	4	13601827	13601827	+	Missense_Mutation	SNP	C	C	A	rs144300104		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:13601827C>A	ENST00000040738.5	-	10	6832	c.6697G>T	c.(6697-6699)Ggt>Tgt	p.G2233C		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	2233							DNA binding										ACAACTACACCGGAAACAGAA	0.488000													5	20					0.0215528	0.0219594	0.217242	1	0
FCGR3B	2215	broad.mit.edu	37	1	161600164	161600164	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:161600164G>A	ENST00000294800.3	-	2	328	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W	FCGR2B_ENST00000428605.2_Intron|FCGR2B_ENST00000403078.3_Intron|FCGR2B_ENST00000367960.5_Intron|FCGR2B_ENST00000367962.4_Intron|FCGR3A_ENST00000540048.1_Missense_Mutation_p.R19W|FCGR3B_ENST00000367964.2_Missense_Mutation_p.R19W|FCGR3B_ENST00000531221.1_Missense_Mutation_p.R55W	NM_001244753.1|NM_001271035.1	NP_001231682.1|NP_001257964.1	O75015	FCG3B_HUMAN	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	19					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	18	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCACCAGTCCGCATGCCAGCT	0.438000													14	96					0	0	0.592651	0	0
CDT1	81620	broad.mit.edu	37	16	88872177	88872177	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:88872177G>T	ENST00000301019.4	+	5	1351	c.732G>T	c.(730-732)ccG>ccT	p.P244P		NM_030928.3	NP_112190.2	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor 1	244					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(3)	7				BRCA - Breast invasive adenocarcinoma(80;0.0476)		CCGTGTACCCGGCCTCCTACC	0.632000													5	34					0.00116845	0.00122517	0.217242	1	0
PORCN	64840	broad.mit.edu	37	X	48372650	48372650	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:48372650G>T	ENST00000367574.4	+	7	1001	c.496G>T	c.(496-498)Gct>Tct	p.A166S	PORCN_ENST00000361988.3_Missense_Mutation_p.A237S|PORCN_ENST00000537758.1_Missense_Mutation_p.A248S|PORCN_ENST00000326194.6_Missense_Mutation_p.A248S|PORCN_ENST00000359882.4_Missense_Mutation_p.A242S|PORCN_ENST00000355961.4_Missense_Mutation_p.A243S|PORCN_ENST00000355092.3_Missense_Mutation_p.A242S			Q9H237	PORCN_HUMAN	porcupine homolog (Drosophila)	248					Wnt receptor signaling pathway	endoplasmic reticulum membrane|integral to membrane	acyltransferase activity			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						CTACGAGAGTGCTGTCTCCTT	0.587000													43	90					8.44121e-28	1.56283e-27	0.870114	1	0
TEKT4P2	100132288	broad.mit.edu	37	21	9907382	9907382	+	RNA	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr21:9907382G>T	ENST00000416067.1	-	0	1410					NR_037872.1|NR_038327.1																						CCTTGAGGTTGCGCAGGGACT	0.582000													7	5					0.00198382	0.002047	0.248553	1	0
CES5A	221223	broad.mit.edu	37	16	55905674	55905674	+	Splice_Site	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:55905674A>T	ENST00000521992.1	-	4	512	c.365_splice	c.e4-1	p.C123_splice	CES5A_ENST00000520435.1_Splice_Site_p.C94_splice|CES5A_ENST00000518005.1_5'UTR|CES5A_ENST00000541580.1_Intron|CES5A_ENST00000319165.9_Splice_Site_p.C94_splice|CES5A_ENST00000290567.9_Splice_Site_p.C94_splice	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	94						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TTCTGGAGGCACCTTGGAGAA	0.512000													10	23					0	0	0.387290	0	0
PEX5L	51555	broad.mit.edu	37	3	179537734	179537734	+	Missense_Mutation	SNP	C	C	T	rs149066916		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:179537734C>T	ENST00000467460.1	-	9	1183	c.853G>A	c.(853-855)Gca>Aca	p.A285T	PEX5L_ENST00000392649.3_Missense_Mutation_p.A177T|PEX5L_ENST00000476138.1_Missense_Mutation_p.A242T|PEX5L_ENST00000485199.1_Missense_Mutation_p.A250T|PEX5L_ENST00000472994.1_Missense_Mutation_p.A226T|PEX5L_ENST00000464614.1_Missense_Mutation_p.A177T|PEX5L_ENST00000263962.8_Missense_Mutation_p.A283T|PEX5L_ENST00000465751.1_Missense_Mutation_p.A261T|PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000468741.1_Missense_Mutation_p.A93T	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	285					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			TCCCATTCTGCTTGCATCTTA	0.443000													42	26					0	0	0.864702	0	0
ZSWIM3	140831	broad.mit.edu	37	20	44506050	44506050	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr20:44506050G>T	ENST00000255152.2	+	2	1062	c.853G>T	c.(853-855)Gac>Tac	p.D285Y	ZSWIM3_ENST00000454862.2_Missense_Mutation_p.D279Y	NM_080752.3	NP_542790.2	Q96MP5	ZSWM3_HUMAN	zinc finger, SWIM-type containing 3	285							zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	35		Myeloproliferative disorder(115;0.0122)				GGTCTTTGTGGACCCTTCATT	0.532000													11	45					3.07112e-06	3.56646e-06	0.387290	1	0
HDAC6	10013	broad.mit.edu	37	X	48681414	48681414	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:48681414A>T	ENST00000334136.5	+	25	2783	c.2605A>T	c.(2605-2607)Aca>Tca	p.T869S	HDAC6_ENST00000444343.2_Missense_Mutation_p.T883S|HDAC6_ENST00000376619.2_Missense_Mutation_p.T869S			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	869					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	GCGGATGACCACACGAGAAAA	0.532000													20	27					0	0	0.639603	0	0
NOS1	4842	broad.mit.edu	37	12	117660627	117660627	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:117660627G>T	ENST00000317775.6	-	26	4553	c.3868C>A	c.(3868-3870)Caa>Aaa	p.Q1290K	NOS1_ENST00000344089.3_3'UTR|NOS1_ENST00000338101.4_Missense_Mutation_p.Q1324K	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	1290					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	ATCTTGGATTGCCGGCACCCG	0.572000													33	61					6.53348e-20	1.09681e-19	0.788014	1	0
STK36	27148	broad.mit.edu	37	2	219538381	219538381	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:219538381C>T	ENST00000295709.3	+	3	397	c.118C>T	c.(118-120)Cgc>Tgc	p.R40C	STK36_ENST00000392106.2_Missense_Mutation_p.R40C|STK36_ENST00000440309.1_Missense_Mutation_p.R40C|STK36_ENST00000392105.3_Missense_Mutation_p.R40C	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	40	Protein kinase.				cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		AAAATTGGGGCGCTCAGAGAA	0.458000													8	26					0	0	0.335167	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140788613	140788613	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:140788613C>A	ENST00000520790.1	+	1	844	c.844C>A	c.(844-846)Cga>Aga	p.R282R	PCDHGB1_ENST00000523390.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTACTACTTCCGAAGCACTGC	0.428000													30	47					1.99505e-19	3.26463e-19	0.760397	1	0
ARHGAP6	395	broad.mit.edu	37	X	11187775	11187775	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:11187775G>C	ENST00000337414.4	-	9	2531	c.1659C>G	c.(1657-1659)aaC>aaG	p.N553K	ARHGAP6_ENST00000303025.6_Missense_Mutation_p.N350K|ARHGAP6_ENST00000491514.1_5'UTR|ARHGAP6_ENST00000380718.1_Missense_Mutation_p.N553K|ARHGAP6_ENST00000413512.3_Missense_Mutation_p.N362K|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.N585K|ARHGAP6_ENST00000534860.1_Missense_Mutation_p.N378K|ARHGAP6_ENST00000380736.1_Missense_Mutation_p.N350K	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	553	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						TGGTGGCTAAGTTTAGAGATG	0.443000													41	74					0	0	0.870114	0	0
DFNB59	494513	broad.mit.edu	37	2	179320756	179320756	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:179320756A>T	ENST00000409117.3	+	4	783	c.427A>T	c.(427-429)Agc>Tgc	p.S143C	DFNB59_ENST00000375129.4_Missense_Mutation_p.S143C|DFNB59_ENST00000605419.1_3'UTR	NM_001042702.3	NP_001036167.1	Q0ZLH3	PJVK_HUMAN	deafness, autosomal recessive 59	143					sensory perception of sound					breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.00406)|Epithelial(96;0.0159)|all cancers(119;0.0564)			CTTTGACCACAGCTTGATACG	0.388000													10	40					0	0	0.387290	0	0
LRP1B	53353	broad.mit.edu	37	2	141457845	141457845	+	Nonsense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:141457845C>T	ENST00000389484.3	-	41	7744	c.6773G>A	c.(6772-6774)tGg>tAg	p.W2258*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2258					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCTGTCTTCCCAGTTGTCTTT	0.313000										TSP Lung(27;0.18)			13	30					0	0	0.435327	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617914	77617914	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:77617914G>T	ENST00000521891.2	+	2	2039	c.1591G>T	c.(1591-1593)Gat>Tat	p.D531Y	ZFHX4_ENST00000455469.2_Missense_Mutation_p.D531Y|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000518282.1_Missense_Mutation_p.D531Y|ZFHX4_ENST00000050961.6_Missense_Mutation_p.D531Y	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	531						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GACTGTTTCTGATGACACAGA	0.448000										HNSCC(33;0.089)			20	27					7.87624e-14	1.14951e-13	0.639603	1	0
KCNC2	3747	broad.mit.edu	37	12	75444384	75444384	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:75444384C>T	ENST00000549446.1	-	3	2081	c.1401G>A	c.(1399-1401)atG>atA	p.M467I	KCNC2_ENST00000548513.1_Missense_Mutation_p.M467I|KCNC2_ENST00000341669.3_Missense_Mutation_p.M467I|KCNC2_ENST00000393288.2_Missense_Mutation_p.M467I|KCNC2_ENST00000550433.1_Missense_Mutation_p.M467I|KCNC2_ENST00000350228.2_Missense_Mutation_p.M467I|KCNC2_ENST00000298972.1_Missense_Mutation_p.M467I|KCNC2_ENST00000540018.1_Missense_Mutation_p.M467I|KCNC2_ENST00000548243.1_5'UTR	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	467					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						CAGGCACTGGCATGGCTATTG	0.502000													14	32					0	0	0.500413	0	0
ABCB5	340273	broad.mit.edu	37	7	20721179	20721179	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:20721179C>G	ENST00000404938.2	+	15	2411	c.1759C>G	c.(1759-1761)Cga>Gga	p.R587G	ABCB5_ENST00000258738.6_Missense_Mutation_p.R142G	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	142	ABC transporter 2.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TTCTACTATTCGAAGTGCAGA	0.398000													26	35					0	0	0.706142	0	0
SPATA18	132671	broad.mit.edu	37	4	52945979	52945979	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:52945979A>G	ENST00000295213.4	+	9	1623	c.1249A>G	c.(1249-1251)Agt>Ggt	p.S417G	SPATA18_ENST00000419395.2_Missense_Mutation_p.S385G	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	417					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TTGCCTTCTCAGTGACTTCAT	0.423000													10	148					0	0	0.361761	0	0
C1orf173	127254	broad.mit.edu	37	1	75078419	75078419	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:75078419C>T	ENST00000326665.5	-	9	1293	c.1075G>A	c.(1075-1077)Gtg>Atg	p.V359M	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.V162M	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	359										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AACCTGTTCACCTGCATCCCA	0.428000													10	19					0	0	0.361761	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119945465	119945465	+	Silent	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:119945465G>C	ENST00000297350.4	-	2	483	c.105C>G	c.(103-105)acC>acG	p.T35T		NM_002546.3	NP_002537.3	O00300	TR11B_HUMAN	tumor necrosis factor receptor superfamily, member 11b	35					apoptosis|skeletal system development		cytokine activity|receptor activity			breast(1)|central_nervous_system(3)|endometrium(4)|large_intestine(6)|lung(7)|prostate(3)|skin(1)	25	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			GCTGATGAGAGGTTTCTTCGT	0.483000													60	172					0	0	0.870114	0	0
WDR27	253769	broad.mit.edu	37	6	170065582	170065582	+	Splice_Site	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:170065582C>A	ENST00000333572.6	-	7	1302	c.783_splice	c.e7+1	p.Q261_splice	WDR27_ENST00000420344.2_Splice_Site_p.S176_splice|WDR27_ENST00000546525.1_5'UTR|WDR27_ENST00000423258.1_Splice_Site_p.Q134_splice|WDR27_ENST00000448612.1_Splice_Site_p.Q261_splice			A2RRH5	WDR27_HUMAN	WD repeat domain 27	231										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(5)|pancreas(1)|skin(1)	12		Breast(66;1.53e-05)|Ovarian(120;0.216)		OV - Ovarian serous cystadenocarcinoma(33;6.48e-20)|BRCA - Breast invasive adenocarcinoma(81;3.56e-07)|GBM - Glioblastoma multiforme(31;0.00168)		GCTGTCTCACCTGGCCGTCAG	0.473000													12	26					4.14922e-12	5.76973e-12	0.500413	1	0
SLC6A5	9152	broad.mit.edu	37	11	20622867	20622867	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:20622867G>T	ENST00000525748.1	+	2	469	c.196G>T	c.(196-198)Gac>Tac	p.D66Y		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	66					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	CCAGTCAGCGGACGCGCGAGC	0.716000													6	9					0.00198382	0.002047	0.248553	1	0
GSDMD	79792	broad.mit.edu	37	8	144641958	144641958	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:144641958G>T	ENST00000526406.1	+	6	1112	c.229G>T	c.(229-231)Ggc>Tgc	p.G77C	GSDMD_ENST00000262580.4_Missense_Mutation_p.G77C|GSDMD_ENST00000533063.1_Missense_Mutation_p.G125C	NM_001166237.1	NP_001159709.1	P57764	GSDMD_HUMAN	gasdermin D	77										breast(1)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	12						CGTGCAGCGTGGCAGGAGCTT	0.687000													24	24					1.17739e-12	1.65141e-12	0.693898	1	0
EIF4E1B	253314	broad.mit.edu	37	5	176070154	176070154	+	Silent	SNP	G	G	A	rs143370383	by1000genomes	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:176070154G>A	ENST00000318682.6	+	4	671	c.87G>A	c.(85-87)acG>acA	p.T29T	EIF4E1B_ENST00000504597.1_Silent_p.T29T	NM_001099408.1	NP_001092878.1	A6NMX2	I4E1B_HUMAN	eukaryotic translation initiation factor 4E family member 1B	29					regulation of translation	cytoplasm|mRNA cap binding complex	translation initiation factor activity			breast(1)|large_intestine(1)|lung(2)|pancreas(1)	5	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.00498)|all_neural(177;0.0212)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CAGAGAGGACGCCCACAGGAG	0.592000													7	42					0	0	0.307466	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162389	33162389	+	RNA	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:33162389C>G	ENST00000510327.1	-	0	346																											CAGCTGCCAACACCAAGATTG	0.597000													14	14					0	0	0.435327	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53217012	53217012	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:53217012G>T	ENST00000342657.3	+	7	1458	c.385G>T	c.(385-387)Gga>Tga	p.G129*	HNRNPA1L2_ENST00000357495.2_Nonsense_Mutation_p.G129*|HNRNPA1L2_ENST00000398039.1_Nonsense_Mutation_p.G129*	NM_001011724.1	NP_001011724.1	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like 2	129	Globular B domain.|RRM 2.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding			cervix(1)|large_intestine(1)|lung(5)	7						TGAACAGTATGGAAAAATTGA	0.398000													20	24					5.49717e-05	5.99691e-05	0.654019	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000256078.4_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			12	26					1.5842e-08	1.96659e-08	0.435327	1	0
SCGB1A1	7356	broad.mit.edu	37	11	62189816	62189816	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:62189816C>A	ENST00000534397.1	+	3	265	c.74C>A	c.(73-75)gCt>gAt	p.A25D	SCGB1A1_ENST00000278282.2_Missense_Mutation_p.A60D|CTD-2531D15.4_ENST00000528983.1_RNA			P11684	UTER_HUMAN	secretoglobin, family 1A, member 1 (uteroglobin)	60					embryo implantation|signal transduction	extracellular region	binding|phospholipase A2 inhibitor activity			lung(1)	1						GAGGCAGGGGCTCAGCTGAAG	0.522000													27	49					1.38854e-25	2.49937e-25	0.729181	1	0
TTC8	123016	broad.mit.edu	37	14	89337895	89337895	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:89337895G>T	ENST00000338104.6	+	12	1152	c.1100G>T	c.(1099-1101)cGg>cTg	p.R367L	TTC8_ENST00000380656.2_Missense_Mutation_p.R351L|TTC8_ENST00000346301.4_Missense_Mutation_p.R311L|TTC8_ENST00000354441.6_Missense_Mutation_p.R86L|TTC8_ENST00000358622.5_Missense_Mutation_p.R153L|TTC8_ENST00000536576.1_Missense_Mutation_p.R112L|TTC8_ENST00000345383.5_Missense_Mutation_p.R341L			Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8	377					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding	p.R351Q(1)		endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						TTGAAAAGGCGGCTGCTGCAG	0.363000													7	34					0.000157383	0.000169409	0.278610	1	0
ABCB5	340273	broad.mit.edu	37	7	20682890	20682890	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:20682890C>G	ENST00000404938.2	+	6	1050	c.398C>G	c.(397-399)gCa>gGa	p.A133G		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	317	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						ATAACTGCAGCACGACAGACC	0.413000													12	16					0	0	0.435327	0	0
HFM1	164045	broad.mit.edu	37	1	91844039	91844039	+	Splice_Site	SNP	T	T	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:91844039T>C	ENST00000370425.3	-	10	1257		c.e10-2		HFM1_ENST00000370424.3_Splice_Site|HFM1_ENST00000294696.5_Splice_Site	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)								ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CCATTTTTCCTAGAGAGAAAA	0.308000													12	43					0	0	0.435327	0	0
USH1C	10083	broad.mit.edu	37	11	17531110	17531110	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:17531110G>T	ENST00000005226.7	-	18	1805	c.1806C>A	c.(1804-1806)ccC>ccA	p.P602P	USH1C_ENST00000527020.1_Intron|USH1C_ENST00000529563.1_Intron|USH1C_ENST00000318024.4_Intron|USH1C_ENST00000527720.1_Intron	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	0					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						GGATGGGAATGGGGGGTGGAG	0.662000													5	14					2.17888e-05	2.41766e-05	0.335167	1	0
NALCN	259232	broad.mit.edu	37	13	101944371	101944371	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:101944371T>A	ENST00000251127.6	-	9	1098	c.1017A>T	c.(1015-1017)agA>agT	p.R339S	NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Missense_Mutation_p.R339S	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	339						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TAGTGCTGCTTCTCGATCCCC	0.428000													8	30					0	0	0.361761	0	0
GRIK2	2898	broad.mit.edu	37	6	102134228	102134228	+	Splice_Site	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:102134228G>A	ENST00000369138.1	+	6	1441	c.951_splice	c.e6+1	p.T317_splice	GRIK2_ENST00000413795.1_Splice_Site_p.T317_splice|GRIK2_ENST00000369137.3_Splice_Site_p.T317_splice|GRIK2_ENST00000369134.4_Splice_Site_p.T268_splice|GRIK2_ENST00000358361.3_Splice_Site_p.T317_splice|GRIK2_ENST00000421544.1_Splice_Site_p.T317_splice|GRIK2_ENST00000318991.6_Splice_Site_p.T317_splice	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	317					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GATTTATGACGGTATGAATAC	0.383000													15	51					0	0	0.592651	0	0
GAB4	128954	broad.mit.edu	37	22	17450873	17450873	+	Silent	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr22:17450873G>A	ENST00000400588.1	-	4	1004	c.897C>T	c.(895-897)caC>caT	p.H299H	GAB4_ENST00000523144.1_Intron	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	299										breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				TGCCTCTGGTGTGGCCATGGG	0.597000													27	72					0	0	0.706142	0	0
OR10H5	284433	broad.mit.edu	37	19	15905792	15905792	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:15905792C>A	ENST00000308940.8	+	1	1032	c.934C>A	c.(934-936)Cca>Aca	p.P312T		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CAAACTCTTTCCACAGAACTG	0.488000													10	22					7.48243e-07	8.88025e-07	0.335167	1	0
KIF26A	26153	broad.mit.edu	37	14	104641579	104641579	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:104641579C>T	ENST00000315264.7	+	11	2415	c.2037C>T	c.(2035-2037)atC>atT	p.I679I	KIF26A_ENST00000423312.2_Silent_p.I818I			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	818					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		TGCCCATCATCCCTGCCCTGA	0.677000													16	24					0	0	0.639603	0	0
PKP2	5318	broad.mit.edu	37	12	33049529	33049529	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:33049529C>G	ENST00000340811.4	-	1	245	c.137G>C	c.(136-138)cGc>cCc	p.R46P	PKP2_ENST00000546741.1_5'UTR|PKP2_ENST00000070846.6_Missense_Mutation_p.R46P	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	46					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					CTGGCCGCCGCGGCCGCTGCT	0.706000													2	4					0	0	0.150653	0	0
KIAA1210	57481	broad.mit.edu	37	X	118220736	118220736	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:118220736G>T	ENST00000402510.2	-	11	4456	c.4457C>A	c.(4456-4458)tCg>tAg	p.S1486*		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	1486										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						ATACTTCTGCGAGGGAGGGGC	0.453000													8	9					5.18039e-06	5.91002e-06	0.278610	1	0
AKAP4	8852	broad.mit.edu	37	X	49957416	49957416	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:49957416C>A	ENST00000376056.2	-	5	2071	c.1921G>T	c.(1921-1923)Gaa>Taa	p.E641*	AKAP4_ENST00000376058.2_Nonsense_Mutation_p.E267*|AKAP4_ENST00000376064.3_Nonsense_Mutation_p.E641*|AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000358526.2_Nonsense_Mutation_p.E650*			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	650					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					TTCTCACCTTCGCATGGATCC	0.463000													51	92					2.0833e-19	3.39191e-19	0.870114	1	0
ZBBX	79740	broad.mit.edu	37	3	167023682	167023682	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:167023682C>T	ENST00000392766.2	-	17	1814	c.1474G>A	c.(1474-1476)Gac>Aac	p.D492N	ZBBX_ENST00000392764.1_Missense_Mutation_p.D463N|ZBBX_ENST00000307529.5_Missense_Mutation_p.D492N|ZBBX_ENST00000392767.2_Missense_Mutation_p.D492N|ZBBX_ENST00000455345.2_Missense_Mutation_p.D492N	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	492						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						TTTTCAATGTCAGAAGAATAC	0.308000													12	9					0	0	0.457914	0	0
TAS1R2	80834	broad.mit.edu	37	1	19166718	19166718	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:19166718C>A	ENST00000375371.3	-	6	1916	c.1895G>T	c.(1894-1896)tGc>tTc	p.C632F		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	632					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	GGCCTGGCGGCAGAGGCAGGT	0.622000													22	41					9.04412e-07	1.06945e-06	0.681144	1	0
COL20A1	57642	broad.mit.edu	37	20	61959724	61959724	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr20:61959724C>A	ENST00000422202.1	+	33	3762	c.3694C>A	c.(3694-3696)Ccc>Acc	p.P1232T	COL20A1_ENST00000326996.6_Missense_Mutation_p.P1251T|COL20A1_ENST00000358894.6_Missense_Mutation_p.P1219T|COL20A1_ENST00000435874.1_Missense_Mutation_p.P1232T			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1219					cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					GAACACCAGGCCCCCCATGCC	0.667000													12	23					0.0167234	0.0170927	0.435327	1	0
ZNF275	10838	broad.mit.edu	37	X	152612488	152612488	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:152612488G>T	ENST00000421401.3	+	4	522	c.345G>T	c.(343-345)ctG>ctT	p.L115L	ZNF275_ENST00000370251.2_Silent_p.L115L|ZNF275_ENST00000370249.2_Silent_p.L62L|ZNF275_ENST00000440091.1_Silent_p.L145L	NM_001080485.3	NP_001073954.3	A6NFS0	A6NFS0_HUMAN	zinc finger protein 275	115						intracellular	nucleic acid binding|zinc ion binding			endometrium(5)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTAAAGTCCTGCTTGTCCAGC	0.547000													22	13					4.59853e-10	6.13137e-10	0.693898	1	0
NOL4	8715	broad.mit.edu	37	18	31432876	31432876	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr18:31432876T>A	ENST00000261592.5	-	11	2144	c.1847A>T	c.(1846-1848)tAt>tTt	p.Y616F	NOL4_ENST00000535475.1_Missense_Mutation_p.Y397F|NOL4_ENST00000589544.1_Missense_Mutation_p.Y514F|NOL4_ENST00000269185.4_Missense_Mutation_p.Y400F|NOL4_ENST00000535384.1_Missense_Mutation_p.Y331F|NOL4_ENST00000538587.1_Missense_Mutation_p.Y542F	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	616						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TGATTCTCGATATCCTGCAAC	0.463000													31	53					0	0	0.796494	0	0
LCE3A	353142	broad.mit.edu	37	1	152595470	152595470	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:152595470C>A	ENST00000335674.1	-	1	109	c.110G>T	c.(109-111)gGg>gTg	p.G37V		NM_178431.1	NP_848518.1	Q5TA76	LCE3A_HUMAN	late cornified envelope 3A	37					keratinization					endometrium(1)|lung(5)	6	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCCACAGCCCCCAGAGCTTGG	0.652000													32	34					1.06647e-15	1.59234e-15	0.788014	1	0
ZNF770	54989	broad.mit.edu	37	15	35274007	35274007	+	Silent	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr15:35274007G>A	ENST00000356321.4	-	3	1973	c.1629C>T	c.(1627-1629)aaC>aaT	p.N543N		NM_014106.3	NP_054825.2	Q6IQ21	ZN770_HUMAN	zinc finger protein 770	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)	29		Lung NSC(122;4.59e-10)|all_lung(180;8.78e-09)		all cancers(64;1.97e-18)|GBM - Glioblastoma multiforme(113;2.11e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0643)		TAGAAAGATTGTTGAAGTTTC	0.353000													17	50					0	0	0.520397	0	0
PAPSS1	9061	broad.mit.edu	37	4	108575897	108575897	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:108575897C>A	ENST00000265174.4	-	8	1327	c.1055G>T	c.(1054-1056)tGt>tTt	p.C352F	PAPSS1_ENST00000511304.1_5'UTR	NM_005443.4	NP_005434.4	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 1	352					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|ovary(1)	16		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		CTGTCTGGCACAGCGCTCCTC	0.493000													28	94					1.74807e-11	2.39989e-11	0.750413	1	0
INSC	387755	broad.mit.edu	37	11	15199873	15199873	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:15199873C>A	ENST00000379554.3	+	5	646	c.600C>A	c.(598-600)tgC>tgA	p.C200*	INSC_ENST00000528567.1_Nonsense_Mutation_p.C153*|INSC_ENST00000530161.1_Nonsense_Mutation_p.C153*|INSC_ENST00000525218.1_Nonsense_Mutation_p.C153*|INSC_ENST00000424273.1_Nonsense_Mutation_p.C153*|INSC_ENST00000379556.3_Nonsense_Mutation_p.C153*	NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	200					cell differentiation|nervous system development	cytoplasm	binding			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						TCTTCAGGTGCCTTCAGGTTG	0.567000													26	62					2.2171e-23	3.90403e-23	0.740014	1	0
PTPRF	5792	broad.mit.edu	37	1	44010767	44010767	+	Silent	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:44010767A>T	ENST00000359947.4	+	3	361	c.21A>T	c.(19-21)ccA>ccT	p.P7P	PTPRF_ENST00000438120.1_Silent_p.P7P|PTPRF_ENST00000372413.3_Silent_p.P7P|PTPRF_ENST00000372414.3_Silent_p.P7P	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	7					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				AGCCAGCCCCAGGGAGGACGA	0.602000													3	6					0	0	0.217242	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105885853	105885853	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:105885853C>A	ENST00000393359.2	-	11	2708	c.2282G>T	c.(2281-2283)tGg>tTg	p.W761L	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.W761L			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	761					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						CTGCACTGACCAGGTGTCAGG	0.652000													13	34					2.61681e-11	3.56239e-11	0.457914	1	0
KIAA1210	57481	broad.mit.edu	37	X	118221403	118221403	+	Missense_Mutation	SNP	A	A	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:118221403A>G	ENST00000402510.2	-	11	3789	c.3790T>C	c.(3790-3792)Tcc>Ccc	p.S1264P		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	1264										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						CTCCCCAAGGACTGTAAAGGG	0.478000													9	4					0	0	0.307466	0	0
PCYT1B	9468	broad.mit.edu	37	X	24690741	24690741	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:24690741G>T	ENST00000379145.1	-	1	53	c.9C>A	c.(7-9)ggC>ggA	p.G3G		NM_001163264.1	NP_001156736.1	Q9Y5K3	PCY1B_HUMAN	phosphate cytidylyltransferase 1, choline, beta	0						endoplasmic reticulum	choline-phosphate cytidylyltransferase activity			breast(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	17					Choline(DB00122)	ACTCCTGATGGCCTACCATGC	0.428000													36	80					4.21674e-32	8.28014e-32	0.870114	1	0
ITGAX	3687	broad.mit.edu	37	16	31383063	31383063	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:31383063C>T	ENST00000268296.4	+	17	2239	c.2118C>T	c.(2116-2118)ctC>ctT	p.L706L	ITGAX_ENST00000562522.1_Silent_p.L706L	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	706					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						TCCGAGTCCTCGGGCTGAAGG	0.652000													17	46					0	0	0.557998	0	0
WDPCP	51057	broad.mit.edu	37	2	63631450	63631450	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:63631450C>A	ENST00000409120.1	-	4	4142	c.592G>T	c.(592-594)Gcc>Tcc	p.A198S	WDPCP_ENST00000409199.1_Missense_Mutation_p.A198S|WDPCP_ENST00000409835.1_5'UTR|WDPCP_ENST00000272321.7_Missense_Mutation_p.A390S|WDPCP_ENST00000398544.3_Missense_Mutation_p.A231S|WDPCP_ENST00000409562.3_Missense_Mutation_p.A390S			O95876	FRITZ_HUMAN	WD repeat containing planar cell polarity effector	390					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(19)|ovary(1)|skin(1)	35						AGCAGAATGGCACCACTTGGG	0.443000													19	49					2.39187e-15	3.54412e-15	0.575678	1	0
PIK3C2B	5287	broad.mit.edu	37	1	204416610	204416610	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:204416610C>A	ENST00000367187.3	-	16	2999	c.2443G>T	c.(2443-2445)Gac>Tac	p.D815Y	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.D815Y	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	815					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			TTGCGCTGGTCTTCTTCCCGG	0.552000													24	80					2.49675e-24	4.44476e-24	0.717897	1	0
RYR2	6262	broad.mit.edu	37	1	237608793	237608793	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:237608793C>A	ENST00000366574.2	+	14	1580	c.1263C>A	c.(1261-1263)agC>agA	p.S421R	RYR2_ENST00000360064.6_Missense_Mutation_p.S419R|RYR2_ENST00000542537.1_Missense_Mutation_p.S405R	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	421					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTATCCGGAGCACAGTCTTCC	0.388000													37	33					2.87052e-16	4.38702e-16	0.812448	1	0
SCARF2	91179	broad.mit.edu	37	22	20780272	20780272	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr22:20780272T>A	ENST00000405555.3	-	11	2061	c.1991A>T	c.(1990-1992)aAg>aTg	p.K664M	SCARF2_ENST00000266214.5_Missense_Mutation_p.K669M	NM_182895.2	NP_878315.1	Q96GP6	SREC2_HUMAN	scavenger receptor class F, member 2	664	Pro-rich.				cell adhesion	integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	10	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			CCAGGACACCTTAGGCTTGGT	0.756000													4	29					0	0	0.307466	0	0
PRRX1	5396	broad.mit.edu	37	1	170695375	170695375	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:170695375C>A	ENST00000239461.6	+	3	745	c.432C>A	c.(430-432)aaC>aaA	p.N144K	PRRX1_ENST00000497230.2_Missense_Mutation_p.N144K|PRRX1_ENST00000367760.3_Missense_Mutation_p.N144K|PRRX1_ENST00000476867.2_3'UTR	NM_022716.2	NP_073207.1	P54821	PRRX1_HUMAN	paired related homeobox 1	144						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(2)|ovary(1)	3	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGTTTCAGAACCGAAGAGCCA	0.473000													12	31					4.36969e-10	5.85033e-10	0.435327	1	0
WNT3A	89780	broad.mit.edu	37	1	228238375	228238375	+	Missense_Mutation	SNP	T	T	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:228238375T>G	ENST00000284523.1	+	3	410	c.332T>G	c.(331-333)tTt>tGt	p.F111C	WNT3A_ENST00000366753.2_Missense_Mutation_p.F111C	NM_033131.3	NP_149122.1	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family, member 3A	111					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	12		Prostate(94;0.0405)				GAGTCGGCCTTTGTCCACGCC	0.617000													20	51					0	0	0.608945	0	0
FRG1	2483	broad.mit.edu	37	4	190884267	190884267	+	Missense_Mutation	SNP	G	G	A	rs114973918	by1000genomes	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:190884267G>A	ENST00000226798.4	+	9	982	c.760G>A	c.(760-762)Gac>Aac	p.D254N		NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	254					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus				NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		ATTGAAAGCCGACAGATACTG	0.299000													10	21					0	0	0.435327	0	0
NID2	22795	broad.mit.edu	37	14	52520643	52520643	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:52520643C>T	ENST00000216286.5	-	5	1082	c.1083G>A	c.(1081-1083)ttG>ttA	p.L361L	NID2_ENST00000541773.1_Silent_p.L308L	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	361						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TGTGAGGATCCAAGGTGGAAG	0.512000													17	58					0	0	0.639603	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58596565	58596565	+	Silent	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:58596565G>A	ENST00000240727.6	-	7	1419	c.1020C>T	c.(1018-1020)gaC>gaT	p.D340D	ZSCAN18_ENST00000600404.1_Silent_p.D396D|ZSCAN18_ENST00000421612.2_Silent_p.D204D|ZSCAN18_ENST00000601144.1_Silent_p.D340D	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	340					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		CGGACTCCGCGTCCTGGGGGT	0.716000													6	36					0	0	0.278610	0	0
SPINK7	84651	broad.mit.edu	37	5	147693707	147693707	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:147693707C>A	ENST00000274565.4	+	3	193	c.132C>A	c.(130-132)ccC>ccA	p.P44P	SPINK7_ENST00000523535.1_Silent_p.P18P|SPINK7_ENST00000514394.1_3'UTR|RP11-373N22.3_ENST00000501695.3_RNA	NM_032566.2	NP_115955.1	P58062	ISK7_HUMAN	serine peptidase inhibitor, Kazal type 7 (putative)	44	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			large_intestine(2)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCCATCCCCTGCCCCATCA	0.478000													70	87					9.42754e-34	1.86251e-33	0.870114	1	0
POPDC3	64208	broad.mit.edu	37	6	105609350	105609350	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:105609350G>T	ENST00000254765.3	-	2	713	c.435C>A	c.(433-435)gcC>gcA	p.A145A	BVES-AS1_ENST00000580854.1_RNA|BVES-AS1_ENST00000580511.1_RNA|POPDC3_ENST00000474760.1_Intron|BVES-AS1_ENST00000369122.3_RNA	NM_022361.4	NP_071756.2	Q9HBV1	POPD3_HUMAN	popeye domain containing 3	145						integral to membrane				NS(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|skin(3)|urinary_tract(1)	26		all_cancers(87;4.87e-05)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0157)|Colorectal(196;0.202)|Lung NSC(302;0.238)				TCCCCTGCATGGCATAACAGT	0.443000													16	65					1.00905e-13	1.46606e-13	0.575678	1	0
MACF1	23499	broad.mit.edu	37	1	39801556	39801556	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:39801556G>A	ENST00000564288.1	+	37	10073	c.9296G>A	c.(9295-9297)aGt>aAt	p.S3099N	MACF1_ENST00000567887.1_Missense_Mutation_p.S3136N|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.S1539N|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000361689.2_Intron|MACF1_ENST00000372915.3_Missense_Mutation_p.S3104N			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	3104					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGGGCCCAGAGTGAACCATTC	0.433000													6	30					0	0	0.248553	0	0
AQP8	343	broad.mit.edu	37	16	25228604	25228604	+	Missense_Mutation	SNP	G	G	T	rs147031036	byFrequency	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:25228604G>T	ENST00000219660.5	+	2	223	c.98G>T	c.(97-99)cGg>cTg	p.R33L	AQP8_ENST00000566125.1_Missense_Mutation_p.R27L	NM_001169.2	NP_001160.2	O94778	AQP8_HUMAN	aquaporin 8	33					cellular response to cAMP	integral to plasma membrane	water channel activity			NS(1)|breast(1)|large_intestine(3)|lung(8)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	16				GBM - Glioblastoma multiforme(48;0.044)		TGGTACGAACGGTTTGTGCAG	0.577000													103	221					1.84609e-46	3.80977e-46	0.870114	1	0
NBPF1	55672	broad.mit.edu	37	1	16902825	16902825	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:16902825G>A	ENST00000430580.2	-	19	2943	c.2056C>T	c.(2056-2058)Ctc>Ttc	p.L686F	NBPF1_ENST00000432949.1_Missense_Mutation_p.L144F|NBPF1_ENST00000287968.8_Missense_Mutation_p.L51F	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	686						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TGTTCTTGGAGGTCCTGCCCC	0.582000													40	889					0	0	0.804634	0	0
PTPN5	84867	broad.mit.edu	37	11	18754225	18754225	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:18754225C>T	ENST00000396170.1	-	12	2411	c.1147G>A	c.(1147-1149)Gag>Aag	p.E383K	PTPN5_ENST00000477854.1_Missense_Mutation_p.E219K|PTPN5_ENST00000396168.1_Missense_Mutation_p.E391K|RP11-1081L13.4_ENST00000527285.1_RNA|PTPN5_ENST00000358540.2_Missense_Mutation_p.E415K|PTPN5_ENST00000396171.4_Missense_Mutation_p.E415K|PTPN5_ENST00000396167.2_Missense_Mutation_p.E383K	NM_001278236.1	NP_001265165.1	P54829	PTN5_HUMAN	protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)	415	Tyrosine-protein phosphatase.					integral to membrane	phosphotyrosine binding|protein tyrosine phosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|prostate(1)|skin(4)	27						GCCACCTGCTCCTCCGGCCAA	0.577000											OREG0020824	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	65	109					0	0	0.870114	0	0
LCE2B	26239	broad.mit.edu	37	1	152659408	152659408	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:152659408C>A	ENST00000368780.3	+	2	143	c.89C>A	c.(88-90)cCt>cAt	p.P30H	LCE2B_ENST00000417924.2_Missense_Mutation_p.P30H	NM_014357.4	NP_055172.1	O14633	LCE2B_HUMAN	late cornified envelope 2B	30	Cys-rich.|Pro-rich.				keratinization					endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	11	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAGTGTCCCCCTAAATGCCTG	0.602000													59	187					4.37588e-27	8.01008e-27	0.870114	1	0
BCAP29	55973	broad.mit.edu	37	7	107254165	107254165	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:107254165G>T	ENST00000379119.2	+	7	771	c.757G>T	c.(757-759)Ggt>Tgt	p.G253C	BCAP29_ENST00000005259.4_Intron|BCAP29_ENST00000379117.2_Intron|BCAP29_ENST00000379121.2_Intron|BCAP29_ENST00000465919.1_Intron|BCAP29_ENST00000445771.2_Missense_Mutation_p.G253C|BCAP29_ENST00000494086.1_Intron	NM_001008405.2	NP_001008405.1	Q9UHQ4	BAP29_HUMAN	B-cell receptor-associated protein 29	176					apoptosis|intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane				cervix(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)|urinary_tract(1)	14						AAAACAGACTGGTTCTAGAAA	0.378000													17	28					1.9806e-07	2.43073e-07	0.624587	1	0
ZNF275	10838	broad.mit.edu	37	X	152612494	152612494	+	Silent	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:152612494C>G	ENST00000421401.3	+	4	528	c.351C>G	c.(349-351)gtC>gtG	p.V117V	ZNF275_ENST00000370251.2_Silent_p.V117V|ZNF275_ENST00000370249.2_Silent_p.V64V|ZNF275_ENST00000440091.1_Silent_p.V147V	NM_001080485.3	NP_001073954.3	A6NFS0	A6NFS0_HUMAN	zinc finger protein 275	117						intracellular	nucleic acid binding|zinc ion binding			endometrium(5)|large_intestine(4)|lung(4)|ovary(1)|prostate(1)|urinary_tract(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TCCTGCTTGTCCAGCACCAGA	0.537000													22	13					0	0	0.681144	0	0
TGM6	343641	broad.mit.edu	37	20	2397989	2397989	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr20:2397989G>C	ENST00000202625.2	+	10	1509	c.1448G>C	c.(1447-1449)cGt>cCt	p.R483P	TGM6_ENST00000381423.1_Missense_Mutation_p.R483P	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	483					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	TGTCTCTGGCGTGACGACCTC	0.637000													14	33					0	0	0.457914	0	0
KLK15	55554	broad.mit.edu	37	19	51330362	51330362	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:51330362G>T	ENST00000326856.4	-	4	379	c.250C>A	c.(250-252)Caa>Aaa	p.Q84K	KLK15_ENST00000596931.1_Missense_Mutation_p.Q84K|KLK15_ENST00000416184.1_Missense_Mutation_p.Q85K|KLK15_ENST00000598239.1_Missense_Mutation_p.Q85K|KLK15_ENST00000301421.2_Missense_Mutation_p.Q85K	NM_001277081.1	NP_001264010.1	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15	85	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GTCCGTAGTTGCTCTGGGCCA	0.652000													25	139					7.26314e-15	1.06966e-14	0.717897	1	0
METTL13	51603	broad.mit.edu	37	1	171759642	171759642	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:171759642G>T	ENST00000361735.3	+	5	1626	c.1360G>T	c.(1360-1362)Gag>Tag	p.E454*	METTL13_ENST00000466643.1_Intron|METTL13_ENST00000362019.3_Nonsense_Mutation_p.E368*|METTL13_ENST00000367737.5_Nonsense_Mutation_p.E298*|METTL13_ENST00000458517.1_Nonsense_Mutation_p.E453*	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	454							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						TGCTGATGCGGAGGACCTCCC	0.537000													26	78					5.60225e-13	7.92633e-13	0.740014	1	0
POMT2	29954	broad.mit.edu	37	14	77767441	77767441	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:77767441G>T	ENST00000261534.4	-	6	1010	c.808C>A	c.(808-810)Ctt>Att	p.L270I		NM_013382.5	NP_037514.2	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	270					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		ACCAATGAAAGACTGAGGTCT	0.507000											OREG0022837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	204					3.28513e-13	4.66834e-13	0.667858	1	0
OR2A5	393046	broad.mit.edu	37	7	143748001	143748001	+	Nonsense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:143748001T>A	ENST00000408906.2	+	1	541	c.507T>A	c.(505-507)tgT>tgA	p.C169*		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	169					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					TGCCCTTCTGTGGGCCCCATG	0.547000													65	100					0	0	0.870114	0	0
DHX34	9704	broad.mit.edu	37	19	47865873	47865873	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:47865873G>T	ENST00000328771.4	+	6	1865	c.1516G>T	c.(1516-1518)Gaa>Taa	p.E506*	DHX34_ENST00000471451.1_Intron	NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	506	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CCTCTATGCCGAATCGGACTA	0.657000													13	28					1.5842e-08	1.96659e-08	0.435327	1	0
DOCK2	1794	broad.mit.edu	37	5	169454899	169454899	+	Missense_Mutation	SNP	C	C	A	rs148138145	byFrequency	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:169454899C>A	ENST00000256935.8	+	34	3494	c.3414C>A	c.(3412-3414)caC>caA	p.H1138Q	DOCK2_ENST00000540750.1_Missense_Mutation_p.H199Q|DOCK2_ENST00000523351.1_3'UTR|DOCK2_ENST00000520908.1_Missense_Mutation_p.H630Q	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1138	DHR-2.|Interaction with CRKL.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGCTGGACCACGAGGTAGAAG	0.478000													37	49					4.14194e-30	7.98802e-30	0.859065	1	0
FUBP1	8880	broad.mit.edu	37	1	78433325	78433325	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:78433325C>T	ENST00000370767.1	-	4	363	c.276G>A	c.(274-276)atG>atA	p.M92I	FUBP1_ENST00000370768.2_Missense_Mutation_p.M92I|FUBP1_ENST00000436586.2_Missense_Mutation_p.M113I			Q96AE4	FUBP1_HUMAN	far upstream element (FUSE) binding protein 1	92					transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(1)|upper_aerodigestive_tract(3)	17						GCTGCTGATGCATCGGTGGTA	0.284000			"""F, N"""		oligodendroglioma								17	38					0	0	0.592651	0	0
SLC8A3	6547	broad.mit.edu	37	14	70634699	70634699	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:70634699C>T	ENST00000381269.2	-	2	1194	c.441G>A	c.(439-441)gaG>gaA	p.E147E	SLC8A3_ENST00000356921.2_Silent_p.E147E|SLC8A3_ENST00000528359.1_Silent_p.E147E|SLC8A3_ENST00000357887.3_Silent_p.E147E|SLC8A3_ENST00000534137.1_Silent_p.E147E	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	147					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		AGAGGAGTATCTCAGGAGCAG	0.483000													13	60					0	0	0.457914	0	0
ENPP1	5167	broad.mit.edu	37	6	132190591	132190591	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:132190591G>T	ENST00000360971.2	+	13	1387	c.1367G>T	c.(1366-1368)cGa>cTa	p.R456L		NM_006208.2	NP_006199.2	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 1	456	Phosphodiesterase.				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(22)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	46	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	CCTGCAGCTCGATTGAGACCC	0.353000													11	42					2.80697e-09	3.56651e-09	0.387290	1	0
SMYD4	114826	broad.mit.edu	37	17	1684657	1684657	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr17:1684657C>G	ENST00000305513.7	-	11	2505	c.2338G>C	c.(2338-2340)Gat>Cat	p.D780H		NM_052928.2	NP_443160.2	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	780							zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(5)|stomach(1)	21						TGGATTTCATCGTCCCATGGG	0.537000													11	46					0	0	0.411799	0	0
IGKV1-16	28938	broad.mit.edu	37	2	89399500	89399500	+	RNA	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:89399500G>C	ENST00000479981.1	-	0	229																											ATAGATCAGGGACTTAGGGGC	0.517000													21	106					0	0	0.740014	0	0
ITGA8	8516	broad.mit.edu	37	10	15559194	15559194	+	Missense_Mutation	SNP	C	C	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:15559194C>G	ENST00000378076.3	-	30	3508	c.3155G>C	c.(3154-3156)aGg>aCg	p.R1052T		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	1052					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CAGCTGTTCCCTGTCGGTCAT	0.443000													15	35					0	0	0.557998	0	0
NPTX1	4884	broad.mit.edu	37	17	78445555	78445555	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr17:78445555C>T	ENST00000306773.4	-	4	1211	c.1054G>A	c.(1054-1056)Gtg>Atg	p.V352M		NM_002522.3	NP_002513.2	Q15818	NPTX1_HUMAN	neuronal pentraxin I	352	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding			kidney(1)|large_intestine(2)|liver(1)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)	11	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			AGCACCAGCACGCCCTGGGGC	0.657000													11	42					0	0	0.411799	0	0
NPAS4	266743	broad.mit.edu	37	11	66191385	66191385	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:66191385A>T	ENST00000311034.2	+	7	1200	c.1024A>T	c.(1024-1026)Atg>Ttg	p.M342L		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	342					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CACTCCGACCATGCTGCCCTC	0.572000													61	136					0	0	0.870114	0	0
MACF1	23499	broad.mit.edu	37	1	39853267	39853267	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:39853267G>C	ENST00000564288.1	+	58	15530	c.14753G>C	c.(14752-14754)tGg>tCg	p.W4918S	MACF1_ENST00000567887.1_Missense_Mutation_p.W4955S|MACF1_ENST00000545844.1_Missense_Mutation_p.W2856S|MACF1_ENST00000317713.7_Missense_Mutation_p.W2856S|MACF1_ENST00000289893.4_Missense_Mutation_p.W3358S|MACF1_ENST00000539005.1_Missense_Mutation_p.W2835S|MACF1_ENST00000361689.2_Missense_Mutation_p.W2856S|MACF1_ENST00000372915.3_Missense_Mutation_p.W4923S			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	4923					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTTGTGCCATGGATAGAAGAT	0.443000													10	30					0	0	0.387290	0	0
ARID3C	138715	broad.mit.edu	37	9	34621488	34621488	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr9:34621488G>T	ENST00000378909.2	-	7	1298	c.1206C>A	c.(1204-1206)ccC>ccA	p.P402P		NM_001017363.1	NP_001017363.1	A6NKF2	ARI3C_HUMAN	AT rich interactive domain 3C (BRIGHT-like)	402	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)	14	all_epithelial(49;0.102)		STAD - Stomach adenocarcinoma(86;0.178)	GBM - Glioblastoma multiforme(74;0.175)		GCCCTGTGGAGGGTGGGGGTG	0.622000													18	49					1.96895e-08	2.43488e-08	0.639603	1	0
ATM	472	broad.mit.edu	37	11	108200963	108200963	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:108200963G>A	ENST00000278616.4	+	50	7715	c.7330G>A	c.(7330-7332)Gag>Aag	p.E2444K	C11orf65_ENST00000525729.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.E2444K	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2444	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GGTTCAGCGAGAGCTGGAGTT	0.363000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			10	19					0	0	0.387290	0	0
GJD2	57369	broad.mit.edu	37	15	35045156	35045156	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr15:35045156C>A	ENST00000290374.4	-	2	965	c.489G>T	c.(487-489)gaG>gaT	p.E163D		NM_020660.2	NP_065711.1	Q9UKL4	CXD2_HUMAN	gap junction protein, delta 2, 36kDa	163					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|urinary_tract(1)	19		all_lung(180;9.67e-07)		all cancers(64;2.75e-18)|GBM - Glioblastoma multiforme(113;1.9e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0156)		CTGGCTCTGTCTCCTTACTGG	0.517000													41	131					1.91693e-13	2.76038e-13	0.870114	1	0
ZSCAN1	284312	broad.mit.edu	37	19	58563979	58563979	+	Missense_Mutation	SNP	G	G	A	rs148775293		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:58563979G>A	ENST00000282326.1	+	5	834	c.587G>A	c.(586-588)cGc>cAc	p.R196H		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	196					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GAAGCGCCCCGCGCCCCTGGC	0.602000													9	42					0	0	0.411799	0	0
PDE2A	5138	broad.mit.edu	37	11	72295353	72295353	+	Silent	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:72295353G>A	ENST00000334456.5	-	19	1787	c.1542C>T	c.(1540-1542)gtC>gtT	p.V514V	PDE2A_ENST00000444035.2_Silent_p.V505V|PDE2A_ENST00000418754.2_Silent_p.V399V|PDE2A_ENST00000376450.3_Silent_p.V258V|PDE2A_ENST00000544570.1_Silent_p.V507V|PDE2A_ENST00000540345.1_Silent_p.V505V	NM_002599.4	NP_002590.1	O00408	PDE2A_HUMAN	phosphodiesterase 2A, cGMP-stimulated	514	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(21)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	36			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CCACACCGATGACCTCTGGGG	0.632000													19	30					0	0	0.592651	0	0
INADL	10207	broad.mit.edu	37	1	62262980	62262980	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:62262980G>T	ENST00000371158.2	+	11	1396	c.1282G>T	c.(1282-1284)Ggt>Tgt	p.G428C	INADL_ENST00000316485.6_Missense_Mutation_p.G428C	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	428	PDZ 3.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						GAACATTCAGGGTTTTGCCAA	0.403000													24	91					1.22384e-17	1.89724e-17	0.769981	1	0
ACSL1	2180	broad.mit.edu	37	4	185681610	185681610	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:185681610C>A	ENST00000515030.1	-	18	2008	c.1683G>T	c.(1681-1683)aaG>aaT	p.K561N	ACSL1_ENST00000507295.1_Missense_Mutation_p.K527N|ACSL1_ENST00000454703.2_Missense_Mutation_p.K390N|ACSL1_ENST00000437665.3_Missense_Mutation_p.K390N|ACSL1_ENST00000281455.2_Missense_Mutation_p.K561N|ACSL1_ENST00000513317.1_Missense_Mutation_p.K561N|ACSL1_ENST00000504342.1_Missense_Mutation_p.K561N			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	561					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CTTGTGCCAGCTTAAATATGT	0.473000													68	239					1.10181e-30	2.15052e-30	0.870114	1	0
HMCN1	83872	broad.mit.edu	37	1	186099673	186099673	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:186099673C>T	ENST00000271588.4	+	85	13303	c.13074C>T	c.(13072-13074)aaC>aaT	p.N4358N	HMCN1_ENST00000367492.2_Silent_p.N4358N	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4358	Ig-like C2-type 43.			N -> H (in Ref. 4).	response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATCCTTCTAACTGGATTGAAC	0.413000													45	66					0	0	0.870114	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110454380	110454380	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:110454380A>T	ENST00000378402.5	+	35	4453	c.4349A>T	c.(4348-4350)tAt>tTt	p.Y1450F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1450	IPT/TIG 7.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AGTGTAATTTATGATGGCAAA	0.393000										HNSCC(38;0.096)			12	33					0	0	0.411799	0	0
GAPDHS	26330	broad.mit.edu	37	19	36029297	36029297	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:36029297G>T	ENST00000222286.4	+	3	450	c.334G>T	c.(334-336)Gaa>Taa	p.E112*		NM_014364.4	NP_055179.1	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	112					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)	11	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	CATTGACCCGGAATACATGGT	0.577000													12	34					4.3838e-07	5.28012e-07	0.435327	1	0
ZFHX4	79776	broad.mit.edu	37	8	77745609	77745609	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:77745609G>T	ENST00000521891.2	+	5	3809	c.3361G>T	c.(3361-3363)Gat>Tat	p.D1121Y	ZFHX4_ENST00000455469.2_Missense_Mutation_p.D1095Y|ZFHX4_ENST00000518282.1_Missense_Mutation_p.D1095Y|ZFHX4_ENST00000050961.6_Missense_Mutation_p.D1095Y	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1095						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTGTGATGATGATCTTACAGA	0.428000										HNSCC(33;0.089)			19	21					7.38237e-10	9.72312e-10	0.706142	1	0
RP1L1	94137	broad.mit.edu	37	8	10469183	10469183	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:10469183G>T	ENST00000382483.3	-	4	2648	c.2425C>A	c.(2425-2427)Cag>Aag	p.Q809K		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	809					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CGTCCAACCTGCAGAACCAAG	0.682000													23	57					1.10513e-12	1.5568e-12	0.624587	1	0
CGN	57530	broad.mit.edu	37	1	151502571	151502571	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:151502571G>T	ENST00000271636.7	+	12	2426	c.2293G>T	c.(2293-2295)Gac>Tac	p.D765Y		NM_020770.2	NP_065821.1	Q9P2M7	CING_HUMAN	cingulin	759	Glu-rich.					myosin complex|tight junction	actin binding|motor activity			NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	Ovarian(49;0.0273)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			ACGACTACGGGACAAGCTGCA	0.582000													38	93					1.67305e-13	2.41994e-13	0.819951	1	0
COLEC11	78989	broad.mit.edu	37	2	3691323	3691323	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:3691323C>T	ENST00000403096.3	+	6	844	c.353C>T	c.(352-354)gCc>gTc	p.A118V	COLEC11_ENST00000418971.2_Missense_Mutation_p.A158V|COLEC11_ENST00000487365.1_3'UTR|COLEC11_ENST00000404205.1_Missense_Mutation_p.A70V|COLEC11_ENST00000402794.1_Missense_Mutation_p.A94V|COLEC11_ENST00000402922.1_Missense_Mutation_p.A94V|COLEC11_ENST00000236693.7_Missense_Mutation_p.A141V|COLEC11_ENST00000382062.2_Missense_Mutation_p.A120V|COLEC11_ENST00000349077.4_Missense_Mutation_p.A144V	NM_001255986.1	NP_001242915.1	Q9BWP8	COL11_HUMAN	collectin sub-family member 11	144						collagen	mannose binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|soft_tissue(1)	22	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.127)		ACAGCTGTCGCCGGTGTGCGC	0.637000													39	79					0	0	0.870114	0	0
LPPR4	9890	broad.mit.edu	37	1	99771279	99771279	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:99771279G>C	ENST00000370185.3	+	7	1502	c.1005G>C	c.(1003-1005)gaG>gaC	p.E335D	LPPR4_ENST00000370184.1_Missense_Mutation_p.E177D|LPPR4_ENST00000457765.1_Missense_Mutation_p.E277D	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		335							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CCAGTGATGAGAGTATGTTTC	0.448000													21	53					0	0	0.639603	0	0
FCRLA	84824	broad.mit.edu	37	1	161681891	161681891	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:161681891T>A	ENST00000367959.2	+	5	978	c.736T>A	c.(736-738)Tca>Aca	p.S246T	FCRLA_ENST00000367949.2_Intron|FCRLA_ENST00000367950.1_Intron|FCRLA_ENST00000367953.3_Missense_Mutation_p.S229T|FCRLA_ENST00000367957.2_Missense_Mutation_p.S100T|FCRLA_ENST00000350710.3_Intron|FCRLA_ENST00000349527.4_Intron|FCRLA_ENST00000309691.6_Missense_Mutation_p.S134T|FCRLA_ENST00000294796.4_Missense_Mutation_p.S89T|FCRLA_ENST00000540926.1_Missense_Mutation_p.S229T|FCRLA_ENST00000236938.6_Missense_Mutation_p.S240T|FCRLA_ENST00000540521.1_Missense_Mutation_p.S106T|FCRLA_ENST00000470841.1_3'UTR|FCRLA_ENST00000546024.1_Missense_Mutation_p.S151T	NM_001184866.1	NP_001171795.1	Q7L513	FCRLA_HUMAN	Fc receptor-like A	223	Ig-like C2-type 2.				cell differentiation	cytoplasm|extracellular region				breast(1)|kidney(12)|large_intestine(4)|lung(13)|prostate(1)|skin(2)|stomach(1)	34	all_cancers(52;2.55e-15)|all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00301)			GGGGCTCTCCTCAGAATTCCA	0.552000													31	73					0	0	0.769981	0	0
MISP	126353	broad.mit.edu	37	19	758716	758716	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:758716C>A	ENST00000215582.6	+	2	1873	c.1770C>A	c.(1768-1770)tcC>tcA	p.S590S		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GGAGCTCCTCCCAGGCATCCG	0.612000													9	21					1.58986e-06	1.85962e-06	0.361761	1	0
C6orf136	221545	broad.mit.edu	37	6	30619113	30619113	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:30619113C>T	ENST00000293604.6	+	4	1370	c.1177C>T	c.(1177-1179)Cgt>Tgt	p.R393C	C6orf136_ENST00000376471.4_Missense_Mutation_p.R78C|C6orf136_ENST00000376473.5_Missense_Mutation_p.R212C|C6orf136_ENST00000528347.2_Missense_Mutation_p.R69C	NM_001161376.1	NP_001154848.1	Q5SQH8	CF136_HUMAN	chromosome 6 open reading frame 136	212										endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						TGCACACCTTCGTTTGGAGGT	0.552000													139	178					0	0	0.870114	0	0
ZAP70	7535	broad.mit.edu	37	2	98354034	98354034	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:98354034C>T	ENST00000264972.5	+	11	1603	c.1388C>T	c.(1387-1389)gCg>gTg	p.A463V	ZAP70_ENST00000463643.1_3'UTR|ZAP70_ENST00000442208.1_Missense_Mutation_p.A337V|ZAP70_ENST00000451498.2_Missense_Mutation_p.A156V	NM_001079.3	NP_001070.2	P43403	ZAP70_HUMAN	zeta-chain (TCR) associated protein kinase 70kDa	463	Protein kinase.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	29						CGTGACCTGGCGGCCCGCAAC	0.587000													20	33					0	0	0.624587	0	0
PDP1	54704	broad.mit.edu	37	8	94934845	94934845	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:94934845G>T	ENST00000396200.3	+	3	909	c.633G>T	c.(631-633)ctG>ctT	p.L211L	PDP1_ENST00000520728.1_Silent_p.L186L|PDP1_ENST00000297598.4_Silent_p.L186L|PDP1_ENST00000517764.1_Silent_p.L186L	NM_001161779.1	NP_001155251.1	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 1	186					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)	18						GCCGGGCACTGCTACCCATTC	0.448000													13	56					4.7546e-09	5.9709e-09	0.500413	1	0
NBAS	51594	broad.mit.edu	37	2	15427201	15427201	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:15427201T>A	ENST00000281513.5	-	42	5159	c.5134A>T	c.(5134-5136)Agt>Tgt	p.S1712C	NBAS_ENST00000441750.1_Missense_Mutation_p.S1592C	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	1712										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						GCTTACCCACTGTCCGTGAAG	0.403000													33	57					0	0	0.779181	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242741262	242741262	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:242741262G>T	ENST00000192314.6	+	3	317	c.186G>T	c.(184-186)acG>acT	p.T62T	AC114730.5_ENST00000437438.1_RNA	NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	62					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		CGCACAAGACGGCCAGCAGCA	0.662000													21	46					6.12954e-19	9.88044e-19	0.681144	1	0
PYROXD1	79912	broad.mit.edu	37	12	21602606	21602606	+	Missense_Mutation	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:21602606G>A	ENST00000538582.1	+	4	935	c.182G>A	c.(181-183)cGt>cAt	p.R61H	PYROXD1_ENST00000545178.1_Missense_Mutation_p.R132H|PYROXD1_ENST00000240651.9_Missense_Mutation_p.R132H			Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 1	132							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|soft_tissue(1)	18						TTAGGAATCCGTGATACAGAC	0.363000													17	29					0	0	0.624587	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553780	140553780	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:140553780C>A	ENST00000231137.3	+	1	1538	c.1364C>A	c.(1363-1365)tCc>tAc	p.S455Y		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		455					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCCAAACCTCCTACACCCTG	0.602000													53	93					5.45122e-27	9.92245e-27	0.870114	1	0
MAP3K15	389840	broad.mit.edu	37	X	19410151	19410151	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:19410151C>A	ENST00000338883.4	-	18	2399	c.2400G>T	c.(2398-2400)gcG>gcT	p.A800A	MAP3K15_ENST00000469203.2_Silent_p.A632A|MAP3K15_ENST00000359173.3_Silent_p.A235A|MAP3K15_ENST00000518578.1_5'UTR	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	800	Protein kinase.						ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					GGTTCACACCCGCAAGACGTT	0.502000													28	37					1.22384e-17	1.89724e-17	0.769981	1	0
NR5A2	2494	broad.mit.edu	37	1	200017678	200017678	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:200017678C>A	ENST00000367362.3	+	5	1088	c.842C>A	c.(841-843)cCc>cAc	p.P281H	NR5A2_ENST00000544748.1_Missense_Mutation_p.P209H|NR5A2_ENST00000236914.3_Missense_Mutation_p.P235H	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	281					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					ACCAGCTCACCCGAGTCCATA	0.507000													35	42					2.05212e-20	3.48108e-20	0.812448	1	0
RRAGB	10325	broad.mit.edu	37	X	55779873	55779873	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:55779873G>T	ENST00000374941.4	+	7	1250	c.661G>T	c.(661-663)Gaa>Taa	p.E221*	RRAGB_ENST00000262850.7_Nonsense_Mutation_p.E249*	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	249					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding			breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						TCAGCAGCTGGAAATGAACCT	0.393000													21	30					3.8784e-16	5.89954e-16	0.608945	1	0
ABCG2	9429	broad.mit.edu	37	4	89013464	89013464	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:89013464G>T	ENST00000237612.3	-	16	2435	c.1890C>A	c.(1888-1890)caC>caA	p.H630Q	ABCG2_ENST00000515655.1_3'UTR	NM_004827.2	NP_004818.2	Q9UNQ0	ABCG2_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 2	630	ABC transmembrane type-2.				cellular iron ion homeostasis|urate metabolic process	integral to membrane|plasma membrane	ATP binding|heme transporter activity|protein homodimerization activity|xenobiotic-transporting ATPase activity			breast(5)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(13)|lung(10)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	42		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;7.02e-05)	Imatinib(DB00619)|Mitoxantrone(DB01204)|Nicardipine(DB00622)|Nitrendipine(DB01054)|Rosuvastatin(DB01098)|Saquinavir(DB01232)|Topotecan(DB01030)	CCAAGGCCACGTGATTCTTCC	0.358000													16	48					1.64113e-05	1.83354e-05	0.592651	1	0
TMC2	117532	broad.mit.edu	37	20	2597952	2597952	+	Silent	SNP	G	G	T	rs141182747		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr20:2597952G>T	ENST00000358864.1	+	16	2190	c.2175G>T	c.(2173-2175)ccG>ccT	p.P725P	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	725						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						ACTGCGGGCCGTTCAGGTGCA	0.622000													14	38					2.4624e-09	3.14101e-09	0.575678	1	0
PTPRF	5792	broad.mit.edu	37	1	44079301	44079301	+	Missense_Mutation	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:44079301A>T	ENST00000359947.4	+	23	4326	c.3986A>T	c.(3985-3987)cAc>cTc	p.H1329L	PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000422171.2_Missense_Mutation_p.H688L|PTPRF_ENST00000438120.1_Missense_Mutation_p.H1320L|PTPRF_ENST00000372413.3_Missense_Mutation_p.H1320L|PTPRF_ENST00000372414.3_Missense_Mutation_p.H1329L	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1329					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				ATGCGAGACCACCCACCCATC	0.572000													17	85					0	0	0.654019	0	0
FOXR2	139628	broad.mit.edu	37	X	55650676	55650676	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:55650676C>A	ENST00000339140.3	+	1	844	c.532C>A	c.(532-534)Cag>Aag	p.Q178K		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	178					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						TTACCAGAGCCAGAAACTATG	0.502000													14	26					1.05317e-09	1.37039e-09	0.457914	1	0
C2orf78	388960	broad.mit.edu	37	2	74040677	74040677	+	Silent	SNP	A	A	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:74040677A>T	ENST00000409561.1	+	2	292	c.171A>T	c.(169-171)gcA>gcT	p.A57A		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	57	Ser-rich.									cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TGAGCAATGCAGCTTTCTTAA	0.483000													15	29					0	0	0.539581	0	0
ZNF586	54807	broad.mit.edu	37	19	58290976	58290976	+	Nonsense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:58290976G>T	ENST00000391702.3	+	4	1259	c.892G>T	c.(892-894)Gga>Tga	p.G298*	ZNF586_ENST00000599802.1_Intron|ZNF586_ENST00000598885.1_Intron|ZNF586_ENST00000396150.4_3'UTR|ZNF586_ENST00000598183.1_Intron|ZNF586_ENST00000396154.2_Nonsense_Mutation_p.G341*	NM_001204814.1	NP_001191743.1	Q9NXT0	ZN586_HUMAN	zinc finger protein 586	341					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)	15		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AGTTCACACTGGAGAAAGGCC	0.453000													33	75					1.99505e-19	3.26463e-19	0.760397	1	0
ISOC1	51015	broad.mit.edu	37	5	128430651	128430651	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:128430651G>T	ENST00000173527.5	+	1	208	c.192G>T	c.(190-192)atG>atT	p.M64I		NM_016048.2	NP_057132.2	Q96CN7	ISOC1_HUMAN	isochorismatase domain containing 1	64						peroxisome	catalytic activity			kidney(2)|lung(7)	9		all_cancers(142;0.0813)|Prostate(80;0.0865)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.138)|OV - Ovarian serous cystadenocarcinoma(64;0.164)		AGATCGACATGCACCGCAAAT	0.642000													17	8					6.94344e-10	9.18235e-10	0.539581	1	0
LANCL3	347404	broad.mit.edu	37	X	37518838	37518838	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:37518838G>T	ENST00000378621.3	+	3	1123	c.821G>T	c.(820-822)tGc>tTc	p.C274F	LANCL3_ENST00000378619.3_Missense_Mutation_p.C274F|TM4SF2_ENST00000465127.1_Intron	NM_198511.2	NP_940913.1	Q6ZV70	LANC3_HUMAN	LanC lantibiotic synthetase component C-like 3 (bacterial)	274							catalytic activity			lung(4)|pancreas(1)	5						GAACAAAACTGCAACTGGCCA	0.507000													26	45					3.28513e-13	4.66834e-13	0.667858	1	0
ANKFN1	162282	broad.mit.edu	37	17	54431215	54431215	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr17:54431215G>T	ENST00000566473.2	+	5	418	c.418G>T	c.(418-420)Gcc>Tcc	p.A140S	ANKFN1_ENST00000318698.2_Missense_Mutation_p.A140S			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	140										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						GGGCAATGAAGCCATGTTTGA	0.438000													28	55					2.04263e-09	2.62624e-09	0.796494	1	0
SLC35G5	83650	broad.mit.edu	37	8	11189033	11189033	+	Missense_Mutation	SNP	G	G	T	rs145196437	byFrequency	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr8:11189033G>T	ENST00000382435.4	+	1	637	c.418G>T	c.(418-420)Gta>Tta	p.V140L		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	140	DUF6 1.					integral to membrane											TTCTTCCACCGTATGCTCCGC	0.577000													78	132					1.07466e-44	2.20373e-44	0.870114	1	0
ITPRIP	85450	broad.mit.edu	37	10	106074291	106074291	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:106074291C>T	ENST00000278071.2	-	3	1971	c.1519G>A	c.(1519-1521)Gtc>Atc	p.V507I	ITPRIP_ENST00000337478.1_Missense_Mutation_p.V507I|ITPRIP_ENST00000358187.2_Missense_Mutation_p.V507I	NM_033397.2	NP_203755.1	Q8IWB1	IPRI_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein	507						plasma membrane				breast(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(9)|upper_aerodigestive_tract(1)	20						CGCTGCAGGACGAAGGGCCGG	0.592000													4	51					0	0	0.150653	0	0
ESPNL	339768	broad.mit.edu	37	2	239039222	239039222	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:239039222C>A	ENST00000343063.3	+	9	2130	c.1867C>A	c.(1867-1869)Cgg>Agg	p.R623R	ESPNL_ENST00000409169.1_Silent_p.R579R|ESPNL_ENST00000409506.1_Silent_p.R255R|ESPNL_ENST00000477241.1_3'UTR	NM_194312.2	NP_919288.2	Q6ZVH7	ESPNL_HUMAN	espin-like	623										endometrium(1)|lung(8)|pancreas(2)|skin(2)	13		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		GCCATCCACCCGGCCCCTGCA	0.697000													3	2					0.00024832	0.00026553	0.150653	1	0
NUP98	4928	broad.mit.edu	37	11	3716680	3716680	+	Splice_Site	SNP	G	G	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:3716680G>A	ENST00000324932.7	-	26	4586	c.4167_splice	c.e26+1	p.P1389_splice	NUP98_ENST00000355260.3_Splice_Site_p.P1389_splice|NUP98_ENST00000359171.4_Splice_Site_p.P1389_splice	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	1406					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		AGAAGATACCGGTTTTCCAGC	0.448000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								39	268					0	0	0.870114	0	0
GAPDHS	26330	broad.mit.edu	37	19	36029295	36029295	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:36029295C>A	ENST00000222286.4	+	3	448	c.332C>A	c.(331-333)cCg>cAg	p.P111Q		NM_014364.4	NP_055179.1	O14556	G3PT_HUMAN	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	111					gluconeogenesis|glycolysis|positive regulation of glycolysis|sperm motility	cytosol	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity|NAD binding|protein binding	p.P111Q(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(8)	11	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		NADH(DB00157)	TTCATTGACCCGGAATACATG	0.577000													12	34					4.3838e-07	5.28012e-07	0.435327	1	0
FBL	2091	broad.mit.edu	37	19	40331126	40331126	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:40331126C>A	ENST00000221801.3	-	3	324	c.211G>T	c.(211-213)Ggt>Tgt	p.G71C		NM_001436.3	NP_001427.2	P22087	FBRL_HUMAN	fibrillarin	71	DMA/Gly-rich.				rRNA processing|tRNA processing	box C/D snoRNP complex|Cajal body	methyltransferase activity|protein binding|RNA binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)	9	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)	Renal(1328;0.000518)|Hepatocellular(1079;0.0893)	Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)	GBM - Glioblastoma multiforme(1328;0.000826)|STAD - Stomach adenocarcinoma(1328;0.138)		CGACCACGACCCCGGTTGCCA	0.587000													70	193					9.04243e-43	1.83109e-42	0.870114	1	0
OR1L3	26735	broad.mit.edu	37	9	125437929	125437929	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr9:125437929T>A	ENST00000304820.2	+	1	615	c.521T>A	c.(520-522)aTc>aAc	p.I174N		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	174					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						TCAAATGTTATCCATCATTTT	0.458000													106	84					0	0	0.870114	0	0
TMTC4	84899	broad.mit.edu	37	13	101278089	101278089	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:101278089C>T	ENST00000342624.5	-	14	1902	c.1644G>A	c.(1642-1644)agG>agA	p.R548R	TMTC4_ENST00000376234.3_Silent_p.R529R|TMTC4_ENST00000328767.5_Silent_p.R418R|TMTC4_ENST00000462211.1_5'UTR	NM_032813.2	NP_116202.2	Q5T4D3	TMTC4_HUMAN	transmembrane and tetratricopeptide repeat containing 4	529						integral to membrane	binding			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTAGCTCATTCCTTTCTTTTA	0.363000													14	30					0	0	0.500413	0	0
ACSM1	116285	broad.mit.edu	37	16	20648082	20648082	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:20648082C>T	ENST00000219151.4	-	10	1441	c.231G>A	c.(229-231)gtG>gtA	p.V77V	ACSM1_ENST00000307493.4_Silent_p.V426V|ACSM1_ENST00000520010.1_Silent_p.V426V			Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	426					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TGAAGAGGCTCACAGGCCTGA	0.537000													21	75					0	0	0.654019	0	0
CLEC9A	283420	broad.mit.edu	37	12	10217401	10217401	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:10217401G>C	ENST00000355819.1	+	8	1155	c.542G>C	c.(541-543)gGa>gCa	p.G181A		NM_207345.2	NP_997228.1	Q6UXN8	CLC9A_HUMAN	C-type lectin domain family 9, member A	181	C-type lectin.				positive regulation of cytokine secretion|receptor-mediated endocytosis	cell surface|integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(2)|urinary_tract(1)	22						TCTCAGGATGGACACAGCGGA	0.448000													27	73					0	0	0.740014	0	0
WWC3	55841	broad.mit.edu	37	X	10094301	10094301	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:10094301G>T	ENST00000380861.4	+	15	2452	c.2061G>T	c.(2059-2061)caG>caT	p.Q687H	WWC3_ENST00000454666.1_Missense_Mutation_p.Q687H	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	687	C2.									NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						AGTCACTTCAGTTATACGTGT	0.557000													50	107					3.53049e-34	7.01765e-34	0.870114	1	0
SERPINB3	6317	broad.mit.edu	37	18	61326666	61326666	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr18:61326666C>T	ENST00000283752.5	-	4	461	c.318G>A	c.(316-318)aaG>aaA	p.K106K	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Silent_p.K106K	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	106					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						CTCCGAAGAGCTTGTTGGCGA	0.413000													39	56					0	0	0.870114	0	0
PRUNE2	158471	broad.mit.edu	37	9	79321405	79321405	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr9:79321405C>A	ENST00000428286.1	-	8	5908	c.4708G>T	c.(4708-4710)Gac>Tac	p.D1570Y	PRUNE2_ENST00000376718.3_Missense_Mutation_p.D1929Y			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1929					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						TTAATTTGGTCTAATTTTACA	0.473000													5	11					0.000602214	0.000635562	0.184627	1	0
ZNF519	162655	broad.mit.edu	37	18	14105257	14105257	+	Nonsense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr18:14105257C>A	ENST00000590202.1	-	3	1434	c.1282G>T	c.(1282-1284)Gga>Tga	p.G428*	ZNF519_ENST00000589203.1_Intron|ZNF519_ENST00000589498.1_Intron	NM_145287.3	NP_660330.2	Q8TB69	ZN519_HUMAN	zinc finger protein 519	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|urinary_tract(1)	18						TGTTTCTCTCCAGTATGGATT	0.408000													33	48					9.80977e-26	1.77562e-25	0.796494	1	0
TGFBRAP1	9392	broad.mit.edu	37	2	105885852	105885852	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr2:105885852C>A	ENST00000393359.2	-	11	2709	c.2283G>T	c.(2281-2283)tgG>tgT	p.W761C	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.W761C			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	761					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						GCTGCACTGACCAGGTGTCAG	0.647000													13	34					2.61681e-11	3.56239e-11	0.457914	1	0
NPAS4	266743	broad.mit.edu	37	11	66191384	66191384	+	Silent	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:66191384C>A	ENST00000311034.2	+	7	1199	c.1023C>A	c.(1021-1023)acC>acA	p.T341T		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	341					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						GCACTCCGACCATGCTGCCCT	0.577000													59	134					2.40041e-21	4.13688e-21	0.870114	1	0
UBQLN3	50613	broad.mit.edu	37	11	5529501	5529501	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:5529501C>A	ENST00000311659.4	-	2	1435	c.1288G>T	c.(1288-1290)Gca>Tca	p.A430S	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	430										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTTTCCCTGCACCATCTTGG	0.522000													40	91					1.41504e-22	2.47822e-22	0.859065	1	0
MSN	4478	broad.mit.edu	37	X	64958955	64958955	+	Missense_Mutation	SNP	G	G	C			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:64958955G>C	ENST00000360270.5	+	12	1640	c.1468G>C	c.(1468-1470)Gct>Cct	p.A490P	MSN_ENST00000486030.1_3'UTR	NM_002444.2	NP_002435.1	P26038	MOES_HUMAN	moesin	490					leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking	apical plasma membrane|cytoskeleton|extrinsic to membrane|microvillus membrane|nucleolus	cell adhesion molecule binding|receptor binding|structural constituent of cytoskeleton		MSN/ALK(6)	breast(4)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	43						TGGGGCAGAGGCTAGTGCTGA	0.562000			T	ALK	ALCL								15	17					0	0	0.457914	0	0
DZIP1	22873	broad.mit.edu	37	13	96242177	96242177	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:96242177C>A	ENST00000347108.3	-	16	2285	c.1853G>T	c.(1852-1854)aGt>aTt	p.S618I	DZIP1_ENST00000376829.2_Missense_Mutation_p.S618I|DZIP1_ENST00000361396.2_Missense_Mutation_p.S599I|DZIP1_ENST00000361156.3_Missense_Mutation_p.S599I			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	618					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			TTGAGAAACACTGCACTGATC	0.378000													8	42					7.48243e-07	8.88025e-07	0.335167	1	0
LIX1	167410	broad.mit.edu	37	5	96430716	96430716	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr5:96430716C>A	ENST00000274382.4	-	6	880	c.585G>T	c.(583-585)caG>caT	p.Q195H	CTD-2215E18.1_ENST00000509481.1_Intron	NM_153234.4	NP_694966.3	Q8N485	LIX1_HUMAN	Lix1 homolog (chicken)	195										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(2)|ovary(1)	10		all_cancers(142;4.28e-07)|all_epithelial(76;1.06e-09)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0318)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.0733)		CTAGAGAATACTGAGAATAGT	0.517000													8	36					1.12685e-05	1.26771e-05	0.307466	1	0
TENM4	26011	broad.mit.edu	37	11	78380773	78380773	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:78380773G>T	ENST00000278550.7	-	32	7079	c.6617C>A	c.(6616-6618)tCc>tAc	p.S2206Y		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		GTCATTGATGGAGACTGTCTG	0.547000													35	52					3.03874e-20	5.12787e-20	0.779181	1	0
DDX43	55510	broad.mit.edu	37	6	74121953	74121953	+	Missense_Mutation	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr6:74121953C>A	ENST00000370336.4	+	11	1464	c.1306C>A	c.(1306-1308)Cgc>Agc	p.R436S	DDX43_ENST00000479773.1_3'UTR	NM_018665.2	NP_061135.2	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	436	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	24						TTCAGTTCATCGCCTCGCACA	0.323000													20	70					8.58068e-18	1.34306e-17	0.717897	1	0
MICALL2	79778	broad.mit.edu	37	7	1498916	1498916	+	Missense_Mutation	SNP	T	T	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr7:1498916T>A	ENST00000297508.7	-	1	222	c.47A>T	c.(46-48)gAg>gTg	p.E16V	MICALL2_ENST00000405088.4_Missense_Mutation_p.E16V	NM_182924.3	NP_891554.1	Q8IY33	MILK2_HUMAN	MICAL-like 2	16	CH.					cytoplasm|cytoskeleton	zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(8)|ovary(2)|skin(2)	19		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		GCGGTAGCCCTCGCACTGCTG	0.701000													6	10					0	0	0.217242	0	0
PAPPA	5069	broad.mit.edu	37	9	119115071	119115071	+	Missense_Mutation	SNP	C	C	A	rs55679739	byFrequency	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr9:119115071C>A	ENST00000328252.3	+	16	4420	c.4051C>A	c.(4051-4053)Cct>Act	p.P1351T	PAPPA_ENST00000534838.1_Missense_Mutation_p.P389T	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1351	Sushi 3.				cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						CGCTCCACCCCCTGTGCCCAA	0.587000													24	37					4.14947e-28	7.7266e-28	0.750413	1	0
OR10H5	284433	broad.mit.edu	37	19	15905793	15905793	+	Missense_Mutation	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:15905793C>T	ENST00000308940.8	+	1	1033	c.935C>T	c.(934-936)cCa>cTa	p.P312L		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						AAACTCTTTCCACAGAACTGC	0.483000													10	22					0	0	0.335167	0	0
OR10S1	219873	broad.mit.edu	37	11	123847682	123847682	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:123847682C>T	ENST00000531945.1	-	1	806	c.717G>A	c.(715-717)gtG>gtA	p.V239V		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGATGCGCAACACAGCTGCCA	0.587000													22	53					0	0	0.693898	0	0
IGHV4-61	28391	broad.mit.edu	37	14	107095460	107095460	+	RNA	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:107095460C>A	ENST00000390630.2	-	0	147																											CCACAGTGAGCCCTGGGATCA	0.612000													26	47					1.08052e-11	1.48974e-11	0.796494	1	0
ATP12A	479	broad.mit.edu	37	13	25284950	25284950	+	Missense_Mutation	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr13:25284950G>T	ENST00000218548.6	+	21	3269	c.2936G>T	c.(2935-2937)gGg>gTg	p.G979V	ATP12A_ENST00000381946.3_Missense_Mutation_p.G973V	NM_001185085.1|NM_001676.5	NP_001172014.1|NP_001667.4	P54707	AT12A_HUMAN	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	973					ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			breast(6)|central_nervous_system(4)|endometrium(3)|kidney(5)|large_intestine(23)|lung(23)|ovary(2)|pancreas(1)|prostate(2)|skin(5)	74		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	ATCTGGGTGGGGATCACCTCA	0.488000													23	24					3.70037e-05	4.07796e-05	0.740014	1	0
DPPA2	151871	broad.mit.edu	37	3	109023336	109023336	+	Silent	SNP	G	G	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:109023336G>T	ENST00000478945.1	-	7	1086	c.840C>A	c.(838-840)ccC>ccA	p.P280P		NM_138815.3	NP_620170.3	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2	280						nucleus	nucleic acid binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TAGCACAGTCGGGGCATAACA	0.428000													28	44					9.04072e-19	1.4501e-18	0.779181	1	0
HFM1	164045	broad.mit.edu	37	1	91784849	91784849	+	Splice_Site	SNP	C	C	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:91784849C>A	ENST00000370425.3	-	24	2779		c.e24+1		HFM1_ENST00000370424.3_Splice_Site|HFM1_ENST00000294696.5_Splice_Site|HFM1_ENST00000462405.1_Splice_Site	NM_001017975.3	NP_001017975.3	A2PYH4	HFM1_HUMAN	HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae)								ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(33)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	75		all_lung(203;0.00961)|Lung NSC(277;0.0351)		all cancers(265;0.000481)|Epithelial(280;0.00863)|OV - Ovarian serous cystadenocarcinoma(397;0.126)|KIRC - Kidney renal clear cell carcinoma(1967;0.171)		CTGTAACATACATCTTGTAAT	0.328000													11	43					1.05317e-09	1.37039e-09	0.457914	1	0
P2RY10	27334	broad.mit.edu	37	X	78216192	78216192	+	Silent	SNP	C	C	T			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:78216192C>T	ENST00000171757.2	+	4	455	c.175C>T	c.(175-177)Ctg>Ttg	p.L59L	P2RY10_ENST00000544091.1_Silent_p.L59L|P2RY10_ENST00000475374.1_3'UTR	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	59						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						CTTGTGGGTTCTGTGCCGCTT	0.418000													4	82					0	0	0.150653	0	0
AGO3	192669	broad.mit.edu	37	1	36505477	36505477	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:36505477delG	ENST00000373191.4	+	15	2278	c.1929delG	c.(1927-1929)ttfs	p.L643fs	AGO3_ENST00000246314.6_Frame_Shift_Del_p.L409fs	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		TCCAGGACTTGGCCTCCATGG	0.463													17	49	---	---	---	---					
CNTN2	6900	broad.mit.edu	37	1	205033506	205033507	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr1:205033506_205033507delGG	ENST00000331830.4	+	11	1581_1582	c.1297_1298delGG	c.(1297-1299)gfs	p.G434fs		NM_005076.3	NP_005067.1	Q02246	CNTN2_HUMAN	contactin 2 (axonal)	434	Ig-like C2-type 5.				axon guidance|clustering of voltage-gated potassium channels	anchored to membrane|juxtaparanode region of axon|myelin sheath|node of Ranvier|synapse part	identical protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(11)|lung(23)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	54	all_cancers(21;0.144)|Breast(84;0.0437)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			CGCGGCCCGCGGGGGAGAGATC	0.614													56	221	---	---	---	---					
SLC6A20	54716	broad.mit.edu	37	3	45823661	45823661	+	Frame_Shift_Del	DEL	A	A	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr3:45823661delA	ENST00000358525.4	-	2	291	c.176delT	c.(175-177)tgfs	p.L59fs	SLC6A20_ENST00000456124.2_Frame_Shift_Del_p.L59fs|SLC6A20_ENST00000353278.4_Frame_Shift_Del_p.L59fs	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	59					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		TTCCAGGTACAAGAGCGGCAT	0.612													14	43	---	---	---	---					
WDFY3	23001	broad.mit.edu	37	4	85676452	85676453	+	Frame_Shift_Ins	INS	-	-	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr4:85676452_85676453insA	ENST00000322366.6	-	34	5932_5933	c.5525_5526insT	c.(5524-5526)tttfs	p.F1842fs	WDFY3_ENST00000295888.4_Frame_Shift_Ins_p.F1842fs			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1842						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		TTCCCAATAATAAAAAAACAGC	0.421													10	53	---	---	---	---					
TLN1	7094	broad.mit.edu	37	9	35705818	35705820	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr9:35705818_35705820delCTT	ENST00000314888.9	-	42	5893_5895	c.5540_5542delAAG	c.(5539-5544)ggt>g	p.EG1847del	TLN1_ENST00000464379.1_Intron|TLN1_ENST00000540444.1_In_Frame_Del_p.EG1781del	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1847	Interaction with SYNM.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACGAAGGAACCTTCTGGTTCACC	0.557													43	145	---	---	---	---					
INA	9118	broad.mit.edu	37	10	105048271	105048273	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr10:105048271_105048273delGAG	ENST00000369849.4	+	3	1394_1396	c.1345_1347delGAG	c.(1345-1347)del	p.E454del		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	454	Poly-Glu.|Tail.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton	p.E449_E450delEE(1)		breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACTTAAGAAAGAGGAGGAGGAGG	0.458													8	128	---	---	---	---					
ATM	472	broad.mit.edu	37	11	108139250	108139251	+	Frame_Shift_Ins	INS	-	-	TTAGGGCAGCTGA			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:108139250_108139251insTTAGGGCAGCTGA	ENST00000278616.4	+	18	3137_3138	c.2752_2753insTTAGGGCAGCTGA	c.(2752-2754)tagfs	p.*918fs	ATM_ENST00000452508.2_Frame_Shift_Ins_p.*918fs	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	918					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TACTGTGTCCTTTAGGGCAGCT	0.391			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			12	169	---	---	---	---					
ZBTB16	7704	broad.mit.edu	37	11	113935185	113935186	+	Frame_Shift_Ins	INS	-	-	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr11:113935185_113935186insG	ENST00000335953.4	+	2	1543_1544	c.1163_1164insG	c.(1162-1164)cggfs	p.R388fs	ZBTB16_ENST00000392996.2_Frame_Shift_Ins_p.R388fs	NM_006006.4	NP_005997.2	Q05516	ZBT16_HUMAN	zinc finger and BTB domain containing 16	388					apoptosis|central nervous system development|mesonephros development|myeloid cell differentiation|negative regulation of myeloid cell differentiation|negative regulation of transcription, DNA-dependent	nuclear speck|PML body|transcriptional repressor complex	protein homodimerization activity|zinc ion binding			central_nervous_system(1)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(2)	6		all_cancers(61;3.79e-18)|all_epithelial(67;2.32e-10)|all_hematologic(158;2.96e-05)|Melanoma(852;0.000362)|Acute lymphoblastic leukemia(157;0.00108)|Breast(348;0.0104)|all_neural(223;0.0294)|Prostate(24;0.0318)|Medulloblastoma(222;0.0438)		BRCA - Breast invasive adenocarcinoma(274;6.75e-06)|Epithelial(105;0.000181)|all cancers(92;0.0018)		TTCAGCAAGCTGGGGGAGCTGG	0.639													31	120	---	---	---	---					
MON2	23041	broad.mit.edu	37	12	62931032	62931032	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr12:62931032delG	ENST00000393630.3	+	15	2393	c.2002delG	c.(2002-2004)ggfs	p.G668fs	MON2_ENST00000552738.1_Frame_Shift_Del_p.G645fs|MON2_ENST00000393632.2_Frame_Shift_Del_p.G668fs|MON2_ENST00000393629.2_Frame_Shift_Del_p.G668fs|MON2_ENST00000552115.1_Frame_Shift_Del_p.G668fs|MON2_ENST00000546600.1_Frame_Shift_Del_p.G668fs|MON2_ENST00000280379.6_Frame_Shift_Del_p.G668fs	NM_001278470.1|NM_001278472.1	NP_001265399.1|NP_001265401.1	Q7Z3U7	MON2_HUMAN	MON2 homolog (S. cerevisiae)	668					Golgi to endosome transport|protein transport	cytoplasm	ARF guanyl-nucleotide exchange factor activity|binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(15)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	57			BRCA - Breast invasive adenocarcinoma(9;0.218)	GBM - Glioblastoma multiforme(28;0.128)		CCAGCCTCAAGGGACAGTAAT	0.393													22	49	---	---	---	---					
BCL11B	64919	broad.mit.edu	37	14	99641544	99641546	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr14:99641544_99641546delCTC	ENST00000345514.2	-	3	1680_1682	c.1414_1416delGAG	c.(1414-1416)del	p.E472del	BCL11B_ENST00000357195.3_In_Frame_Del_p.E543del|BCL11B_ENST00000443726.2_In_Frame_Del_p.E349del	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	543						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		CCAGTAGCAGctcctcctcctcc	0.700			T	TLX3	T-ALL								2	4	---	---	---	---					
CHEK2P2	646096	broad.mit.edu	37	15	20490739	20490739	+	RNA	DEL	G	G	-	rs143465906		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr15:20490739delG	ENST00000555186.1	+	0	568					NR_038836.1																						GTTACAACCTGtttttttttt	0.423													2	4	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102299886	102299887	+	RNA	INS	-	-	G			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr15:102299886_102299887insG	ENST00000561463.1	+	0	7932_7933																											AACCTGTACTCGCGTCGGAACC	0.589													5	6	---	---	---	---					
IL9RP3	729486	broad.mit.edu	37	16	81771	81772	+	RNA	INS	-	-	A			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:81771_81772insA	ENST00000568710.1	-	0	434																											CCCTGCCCCCCATGTCCTGCTG	0.569													53	90	---	---	---	---					
IL32	9235	broad.mit.edu	37	16	3119304	3119305	+	Frame_Shift_Ins	INS	-	-	G	rs2981599		TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr16:3119304_3119305insG	ENST00000525643.2	+	7	847_848	c.515_516insG	c.(514-516)gaafs	p.E172fs	IL32_ENST00000552936.1_Frame_Shift_Ins_p.E196fs|IL32_ENST00000528163.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000548652.1_Frame_Shift_Ins_p.E163fs|IL32_ENST00000529550.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552356.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000530538.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000534507.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000548476.1_Frame_Shift_Ins_p.E218fs|IL32_ENST00000396887.3_Frame_Shift_Ins_p.E115fs|IL32_ENST00000530890.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000529699.1_Frame_Shift_Ins_p.E152fs|IL32_ENST00000325568.5_Frame_Shift_Ins_p.E172fs|IL32_ENST00000396890.2_Frame_Shift_Ins_p.E218fs|IL32_ENST00000526464.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000552664.1_Frame_Shift_Ins_p.E172fs|IL32_ENST00000531965.1_Frame_Shift_Ins_p.E162fs|IL32_ENST00000382213.3_Frame_Shift_Ins_p.E163fs|IL32_ENST00000533097.2_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551513.1_Frame_Shift_Ins_p.E209fs|IL32_ENST00000444393.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000440815.3_Frame_Shift_Ins_p.E172fs|IL32_ENST00000551122.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000549213.1_Frame_Shift_Ins_p.E115fs|IL32_ENST00000008180.9_Frame_Shift_Ins_p.E152fs|IL32_ENST00000548246.1_Frame_Shift_Ins_p.E132fs			P24001	IL32_HUMAN	interleukin 32	218					cell adhesion|defense response|immune response	extracellular space	cytokine activity			breast(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	15						CCACGGGGGGACAAGGAGGAGC	0.574													46	216	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684390	26684391	+	Frame_Shift_Ins	INS	-	-	C	rs148075904	by1000genomes	TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr17:26684390_26684391insC	ENST00000540200.1	-	2	80_81	c.81_82insG	c.(79-84)aacgctfs	p.NA27fs	POLDIP2_ENST00000003607.4_5'UTR	NM_015584.3	NP_056399.1	Q9Y2S7	PDIP2_HUMAN	polymerase (DNA-directed), delta interacting protein 2	28						mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		GCACAGAGCGGCTTTGCCACCG	0.762													4	2	---	---	---	---					
LAMA3	3909	broad.mit.edu	37	18	21294017	21294017	+	Frame_Shift_Del	DEL	T	T	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr18:21294017delT	ENST00000313654.9	+	2	669	c.428delT	c.(427-429)ccfs	p.L143fs	LAMA3_ENST00000399516.3_Frame_Shift_Del_p.L143fs	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	143	Laminin N-terminal.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGAGTCAACCTCACCTTGGAT	0.473													25	54	---	---	---	---					
C19orf44	84167	broad.mit.edu	37	19	16612157	16612157	+	Frame_Shift_Del	DEL	C	C	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:16612157delC	ENST00000221671.3	+	2	710	c.554delC	c.(553-555)tcfs	p.S185fs	CTD-3222D19.2_ENST00000409035.1_Intron|C19orf44_ENST00000594035.1_Frame_Shift_Del_p.S185fs	NM_032207.2	NP_115583.1	Q9H6X5	CS044_HUMAN	chromosome 19 open reading frame 44	185										endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	16						GAAAACATATCCCCTGAAGCA	0.448													27	18	---	---	---	---					
PTOV1	53635	broad.mit.edu	37	19	50363317	50363323	+	Frame_Shift_Del	DEL	GAAAATC	GAAAATC	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chr19:50363317_50363323delGAAAATC	ENST00000391842.1	+	11	1286_1292	c.1116_1122delGAAAATC	c.(1114-1122)aafs	p.KKI372fs	PTOV1_ENST00000221557.9_Frame_Shift_Del_p.RKS317fs|PTOV1_ENST00000600603.1_Frame_Shift_Del_p.RKS317fs|PTOV1_ENST00000598325.1_3'UTR|PTOV1_ENST00000601675.1_Frame_Shift_Del_p.KKI372fs|PTOV1_ENST00000599732.1_Frame_Shift_Del_p.KKI372fs|PTOV1_ENST00000601638.1_Frame_Shift_Del_p.KKI340fs|AC018766.4_ENST00000596624.1_RNA	NM_017432.3	NP_059128.2	Q86YD1	PTOV1_HUMAN	prostate tumor overexpressed 1	372	Interaction with FLOT1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|plasma membrane				endometrium(5)|kidney(3)|large_intestine(2)|lung(5)|ovary(1)	16		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		CTTCAGAGAAGAAAATCTTCATTGGCC	0.575													12	67	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50213063	50213063	+	RNA	DEL	G	G	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:50213063delG	ENST00000376025.2	-	0	674							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTGGCGTTCTGggcgatggcg	0.557													23	37	---	---	---	---					
HUWE1	10075	broad.mit.edu	37	X	53565946	53565946	+	Frame_Shift_Del	DEL	G	G	-			TCGA-69-7973-01A-11D-2184-08	TCGA-69-7973-10A-01D-2184-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	08f9cf60-1bd5-4180-9c94-bc828ece9445	b268e88d-a6ec-4824-a6d1-0e770cdc63b0	g.chrX:53565946delG	ENST00000342160.3	-	75	12185	c.11728delC	c.(11728-11730)acfs	p.H3910fs	HUWE1_ENST00000262854.6_Frame_Shift_Del_p.H3910fs			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3910					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						TCCTTGATGTGTGCCAGCTGG	0.617													15	16	---	---	---	---					
