Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CEBPZ	10153	broad.mit.edu	37	2	37430153	37430153	+	Splice_Site	SNP	T	T	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr2:37430153T>A	ENST00000234170.5	-	14	3030		c.e14-2		AC007390.5_ENST00000406711.1_Intron|AC007390.5_ENST00000397064.2_Intron|AC007390.5_ENST00000392061.2_Intron|AC007390.5_ENST00000402297.1_3'UTR	NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta						regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding	p.?(1)		breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				TTCTTGGCCCTAAAAAAAATT	0.269000													3	47					0	0	0.150653	0	0
TOP1	7150	broad.mit.edu	37	20	39725971	39725971	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr20:39725971A>G	ENST00000361337.2	+	10	1092	c.842A>G	c.(841-843)gAc>gGc	p.D281G		NM_003286.2	NP_003277.1	P11387	TOP1_HUMAN	topoisomerase (DNA) I	281					DNA topological change|interspecies interaction between organisms|phosphorylation|programmed cell death|response to drug	chromosome|nucleolus|nucleoplasm	ATP binding|chromatin DNA binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA topoisomerase type I activity|protein binding	p.D281G(1)		breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(115;0.00878)			Irinotecan(DB00762)|Lucanthone(DB04967)|Topotecan(DB01030)	TTCTTTAAAGACTGGAGAAAG	0.348000			T	NUP98	AML*								7	97					0	0	0.278610	0	0
KRIT1	889	broad.mit.edu	37	7	91870326	91870326	+	Silent	SNP	A	A	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr7:91870326A>T	ENST00000394507.1	-	6	1026	c.243T>A	c.(241-243)ccT>ccA	p.P81P	KRIT1_ENST00000394505.2_Silent_p.P81P|KRIT1_ENST00000394503.2_Silent_p.P81P|KRIT1_ENST00000412043.2_Silent_p.P81P|KRIT1_ENST00000340022.2_Silent_p.P81P	NM_194456.1	NP_919438.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	81					angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity	p.P81P(1)		autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(2)|stomach(1)	22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			CCTGGTTTGCAGGAGAAATTG	0.313000													22	65					0	0	0.639603	0	0
RLF	6018	broad.mit.edu	37	1	40703541	40703541	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:40703541C>G	ENST00000372771.4	+	8	3194	c.3167C>G	c.(3166-3168)aCa>aGa	p.T1056R		NM_012421.3	NP_036553.2	Q13129	RLF_HUMAN	rearranged L-myc fusion	1056					chromosome organization|DNA integration|DNA mediated transformation|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding	p.T1056R(1)		NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(18)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(4)|urinary_tract(2)	68	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;5.87e-19)|Epithelial(16;7.02e-16)|all cancers(16;1.69e-14)|Lung(16;0.0427)|LUSC - Lung squamous cell carcinoma(16;0.0461)			AGGCCCTGTACAGAGGATACC	0.398000													7	70					0	0	0.278610	0	0
ZNF678	339500	broad.mit.edu	37	1	227843479	227843479	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:227843479A>C	ENST00000343776.4	+	4	1873	c.1528A>C	c.(1528-1530)Att>Ctt	p.I510L	ZNF678_ENST00000498759.1_Intron|ZNF678_ENST00000397097.3_Missense_Mutation_p.I565L			F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	565					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.I565L(1)|p.I510L(1)		central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				GTATAAGAGAATTTATACTGG	0.323000													6	41					0	0	0.278610	0	0
VBP1	7411	broad.mit.edu	37	X	154456758	154456758	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:154456758G>T	ENST00000286428.5	+	4	495	c.378G>T	c.(376-378)tgG>tgT	p.W126C	VBP1_ENST00000535916.1_Missense_Mutation_p.W121C	NM_003372.5	NP_003363.1	P61758	PFD3_HUMAN	von Hippel-Lindau binding protein 1	126					'de novo' posttranslational protein folding	nucleus|prefoldin complex	unfolded protein binding	p.W126C(1)		NS(1)|endometrium(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGTGTCTGTGGTTGGGGGTAA	0.398000													11	155					6.40141e-05	7.3159e-05	0.387290	1	0
RIOK2	55781	broad.mit.edu	37	5	96503577	96503577	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:96503577C>T	ENST00000283109.3	-	8	1059	c.991G>A	c.(991-993)Gga>Aga	p.G331R	CTD-2215E18.1_ENST00000509481.1_Intron|RIOK2_ENST00000508447.1_Missense_Mutation_p.G331R	NM_018343.2	NP_060813.2	Q9BVS4	RIOK2_HUMAN	RIO kinase 2	331	Protein kinase.						ATP binding|protein serine/threonine kinase activity	p.G331R(2)		breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|urinary_tract(2)	23		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		AATTCAGATCCCTCTTTTGTT	0.418000													12	250					0	0	0.435327	0	0
MLLT4	4301	broad.mit.edu	37	6	168299086	168299086	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr6:168299086G>A	ENST00000366806.2	+	11	1661	c.1519G>A	c.(1519-1521)Gct>Act	p.A507T	MLLT4_ENST00000392108.3_Missense_Mutation_p.A507T|MLLT4_ENST00000392112.1_Missense_Mutation_p.A491T|MLLT4_ENST00000400822.3_Missense_Mutation_p.A506T|MLLT4_ENST00000351017.4_Missense_Mutation_p.A507T|MLLT4_ENST00000447894.2_Missense_Mutation_p.A507T|MLLT4_ENST00000344191.4_Missense_Mutation_p.A507T			P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	507					adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding	p.A491T(1)|p.A507T(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(13)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	65		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		TCAGGATCATGCTCTTGCAAA	0.453000			T	MLL	AL								5	33					0	0	0.248553	0	0
MAST4	375449	broad.mit.edu	37	5	66400349	66400349	+	Silent	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:66400349C>T	ENST00000404260.3	+	10	1619	c.1311C>T	c.(1309-1311)atC>atT	p.I437I	MAST4_ENST00000490016.2_Silent_p.I245I|MAST4_ENST00000405643.1_Silent_p.I255I|MAST4_ENST00000403625.2_Silent_p.I434I|MAST4_ENST00000261569.7_Silent_p.I240I|MAST4_ENST00000403666.1_Silent_p.I245I			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	437						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.I437I(1)		breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		AGGGCCTCATCACCTCACGAT	0.413000													4	36					0	0	0.184627	0	0
NGFR	4804	broad.mit.edu	37	17	47587854	47587854	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr17:47587854G>T	ENST00000172229.3	+	4	774	c.649G>T	c.(649-651)Gca>Tca	p.A217S	RP5-1029K10.2_ENST00000514506.1_RNA|NGFR_ENST00000504201.1_Missense_Mutation_p.A123S	NM_002507.3	NP_002498.1	P08138	TNR16_HUMAN	nerve growth factor receptor	217	Ser/Thr-rich.				anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|membrane protein intracellular domain proteolysis|negative regulation of axonogenesis|negative regulation of cell cycle|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis	cell surface|cytosol|endosome|extracellular region|integral to plasma membrane|nucleoplasm		p.A217S(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)	17	all_cancers(4;1.45e-13)|Breast(4;6.34e-28)|all_epithelial(4;4.95e-17)					GGAGCCTGAGGCACCTCCAGA	0.642000													5	43					0.00116845	0.00129428	0.217242	1	0
CD2BP2	10421	broad.mit.edu	37	16	30365563	30365563	+	Missense_Mutation	SNP	C	C	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr16:30365563C>A	ENST00000305596.3	-	3	334	c.159G>T	c.(157-159)gaG>gaT	p.E53D	CD2BP2_ENST00000569466.1_Missense_Mutation_p.E53D	NM_006110.2	NP_006101.1	O95400	CD2B2_HUMAN	CD2 (cytoplasmic tail) binding protein 2	53					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding	p.E53D(2)		breast(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)	15						CATCATCATCCTCCTCCTCAT	0.517000													41	205					6.2361e-21	7.36065e-21	0.834066	1	0
NLRC4	58484	broad.mit.edu	37	2	32475459	32475459	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr2:32475459G>A	ENST00000404025.2	-	5	1962	c.1474C>T	c.(1474-1476)Cgg>Tgg	p.R492W	NLRC4_ENST00000402280.1_Missense_Mutation_p.R492W|NLRC4_ENST00000342905.6_Intron|NLRC4_ENST00000360906.5_Missense_Mutation_p.R492W			Q9NPP4	NLRC4_HUMAN	NLR family, CARD domain containing 4	492					activation of caspase activity|defense response to bacterium|detection of bacterium|interleukin-1 beta secretion|positive regulation of apoptosis	cytoplasm	ATP binding|magnesium ion binding|protein homodimerization activity	p.R492W(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(1)|ovary(3)|skin(2)|stomach(2)	16	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					CAGGTGTACCGGAGCAGGCTG	0.517000													4	44					0	0	0.150653	0	0
CASC5	57082	broad.mit.edu	37	15	40913729	40913729	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr15:40913729C>G	ENST00000346991.5	+	11	1735	c.1345C>G	c.(1345-1347)Caa>Gaa	p.Q449E	CASC5_ENST00000527044.1_3'UTR|CASC5_ENST00000399668.2_Missense_Mutation_p.Q423E			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	449	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding	p.Q449E(2)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		TCCATCTATTCAAGGTTGTAA	0.363000													10	153					0	0	0.361761	0	0
DCAF12	25853	broad.mit.edu	37	9	34093435	34093435	+	Silent	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr9:34093435G>T	ENST00000361264.4	-	7	1214	c.873C>A	c.(871-873)acC>acA	p.T291T	RP11-537H15.3_ENST00000448245.1_RNA	NM_015397.3	NP_056212.1	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	291						centrosome|CUL4 RING ubiquitin ligase complex		p.T291T(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)	11						ATGGCAGTTTGGTGGAGAGGA	0.493000													3	37					0.115264	0.120275	0.115264	1	0
DENND5B	160518	broad.mit.edu	37	12	31566417	31566417	+	Silent	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:31566417G>T	ENST00000389082.5	-	13	2898	c.2634C>A	c.(2632-2634)ctC>ctA	p.L878L	DENND5B_ENST00000306833.6_Silent_p.L913L|DENND5B_ENST00000536562.1_Silent_p.L913L	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	878	RUN 1.					integral to membrane		p.L878L(1)		NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GCTGGGACAAGAGCTTCTTTT	0.403000													6	67					0.00198382	0.00213186	0.248553	1	0
ADAMTS6	11174	broad.mit.edu	37	5	64748738	64748738	+	Silent	SNP	T	T	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:64748738T>G	ENST00000536360.1	-	5	1452	c.639A>C	c.(637-639)acA>acC	p.T213T				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	213					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.T213T(1)		breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		TGCCACTTCTTGTGAAATCTA	0.348000													6	105					0	0	0.248553	0	0
TESK1	7016	broad.mit.edu	37	9	35608495	35608495	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr9:35608495C>T	ENST00000336395.5	+	9	1239	c.989C>T	c.(988-990)aCa>aTa	p.T330I	TESK1_ENST00000498522.1_3'UTR	NM_006285.2	NP_006276.2	Q15569	TESK1_HUMAN	testis-specific kinase 1	330					cell junction assembly|spermatogenesis	cytosol	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.T330I(1)		breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	27			Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			ACCGCCCTGACACACAATCAG	0.572000													4	13					0	0	0.217242	0	0
ZMYM6	9204	broad.mit.edu	37	1	35476084	35476084	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:35476084G>A	ENST00000357182.4	-	10	1683	c.1456C>T	c.(1456-1458)Cga>Tga	p.R486*	ZMYM6_ENST00000493328.1_5'UTR|ZMYM6_ENST00000373340.2_Nonsense_Mutation_p.R486*|ZMYM6_ENST00000487874.1_Nonsense_Mutation_p.R486*	NM_007167.3	NP_009098.3	O95789	ZMYM6_HUMAN	zinc finger, MYM-type 6	486					multicellular organismal development	nucleus	DNA binding|zinc ion binding	p.R486*(1)		breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(10)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	44		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.13)				CCTGAGAATCGCACAGTCTCC	0.373000													7	126					0	0	0.278610	0	0
PODN	127435	broad.mit.edu	37	1	53543418	53543418	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:53543418T>A	ENST00000371500.3	+	9	1228	c.887T>A	c.(886-888)cTa>cAa	p.L296Q	PODN_ENST00000312553.5_Missense_Mutation_p.L315Q|RP11-334A14.5_ENST00000447867.1_RNA|PODN_ENST00000395871.2_Missense_Mutation_p.L173Q	NM_001199080.1	NP_001186009.1	Q7Z5L7	PODN_HUMAN	podocan	267					negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						CTGCGCGAGCTATACCTGCAG	0.617000													11	146					0	0	0.411799	0	0
ZNF33A	7581	broad.mit.edu	37	10	38345409	38345409	+	Missense_Mutation	SNP	A	A	G	rs71491230	byFrequency	TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr10:38345409A>G	ENST00000374618.3	+	5	2535	c.2357A>G	c.(2356-2358)cAg>cGg	p.Q786R	ZNF33A_ENST00000458705.2_Missense_Mutation_p.Q785R|ZNF33A_ENST00000469037.2_Intron|ZNF33A_ENST00000432900.2_Missense_Mutation_p.Q792R|ZNF33A_ENST00000307441.9_Missense_Mutation_p.Q785R	NM_001278170.1|NM_001278171.1|NM_001278173.1|NM_001278174.1|NM_001278175.1|NM_001278176.1|NM_001278177.1|NM_001278178.1|NM_001278179.1|NM_006954.1|NM_006974.2	NP_001265099.1|NP_001265100.1|NP_001265102.1|NP_001265103.1|NP_001265104.1|NP_001265105.1|NP_001265106.1|NP_001265107.1|NP_001265108.1|NP_008885.1|NP_008905.1	Q06730	ZN33A_HUMAN	zinc finger protein 33A	785						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.Q785R(1)		cervix(2)|endometrium(2)|large_intestine(8)|liver(2)|lung(27)|ovary(2)|prostate(1)|skin(2)	46						AGAAATTTCCAGCCACAAGTC	0.383000													4	75					0	0	0.150653	0	0
FILIP1	27145	broad.mit.edu	37	6	76023514	76023514	+	Silent	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr6:76023514A>G	ENST00000393004.2	-	5	2255	c.2034T>C	c.(2032-2034)tcT>tcC	p.S678S	FILIP1_ENST00000370020.1_Silent_p.S579S|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Silent_p.S678S			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	678								p.S678S(1)		breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						CTAGTTGTTGAGAGAGGAAGT	0.433000													16	248					0	0	0.479597	0	0
FAM71B	153745	broad.mit.edu	37	5	156589943	156589943	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:156589943G>A	ENST00000302938.4	-	2	1428	c.1333C>T	c.(1333-1335)Cat>Tat	p.H445Y		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	445						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TTGCGGTGATGAGAACTTTTC	0.502000													7	153					0	0	0.307466	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004327	75004327	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:75004327A>C	ENST00000373359.2	-	1	752	c.560T>G	c.(559-561)aTc>aGc	p.I187S		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	187	MAGE 1.							p.I187S(1)		autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ATTCAAGAGGATGTGGCCTAG	0.502000													5	41					0	0	0.184627	0	0
RELL2	285613	broad.mit.edu	37	5	141018407	141018407	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:141018407G>C	ENST00000297164.3	+	2	1430	c.230G>C	c.(229-231)cGc>cCc	p.R77P	RELL2_ENST00000518856.1_Missense_Mutation_p.R11P|RELL2_ENST00000521367.1_Missense_Mutation_p.R11P|RELL2_ENST00000444782.1_Missense_Mutation_p.R77P|RELL2_ENST00000518025.1_3'UTR	NM_173828.4	NP_776189.3	Q8NC24	RELL2_HUMAN	RELT-like 2	77						integral to membrane|plasma membrane		p.R77P(1)		large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGATTGTTCGCTGCATCATC	0.507000													4	85					0	0	0.184627	0	0
IGLV1-44	28823	broad.mit.edu	37	22	22735488	22735488	+	RNA	SNP	C	C	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr22:22735488C>A	ENST00000390297.2	+	0	239																											ATCTCTTGTTCTGGAAGCAGC	0.567000													9	94					0.00448238	0.00474605	0.307466	1	0
SFTPA2	729238	broad.mit.edu	37	10	81319085	81319085	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr10:81319085C>T	ENST00000372325.2	-	3	239	c.155G>A	c.(154-156)gGa>gAa	p.G52E	SFTPA2_ENST00000372327.5_Missense_Mutation_p.G52E	NM_001098668.2	NP_001092138.1	Q8IWL1	SFPA2_HUMAN	surfactant protein A2	52	Collagen-like.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding	p.G52E(1)		endometrium(1)|kidney(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			GCCAGGGTCTCCTTTGACACC	0.632000									Pulmonary Fibrosis, Idiopathic				5	77					0	0	0.217242	0	0
FTH1P3	2498	broad.mit.edu	37	5	17354181	17354181	+	RNA	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:17354181A>G	ENST00000511821.1	+	0	101				FTH1P10_ENST00000401830.3_RNA																							CAGTTTGTGCAGTTCCAGTAG	0.448000													14	101					0	0	0.479597	0	0
ZBTB3	79842	broad.mit.edu	37	11	62519814	62519814	+	Silent	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr11:62519814G>A	ENST00000394807.3	-	2	1598	c.1473C>T	c.(1471-1473)gcC>gcT	p.A491A		NM_024784.3	NP_079060.1	Q9H5J0	ZBTB3_HUMAN	zinc finger and BTB domain containing 3	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A491A(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(9)|ovary(2)|prostate(2)	24						TGTGCACCGTGGCATGTCGCC	0.567000													4	34					0	0	0.184627	0	0
OR6C68	403284	broad.mit.edu	37	12	55886450	55886450	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:55886450A>G	ENST00000379662.1	+	1	304	c.304A>G	c.(304-306)Att>Gtt	p.I102V	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|OR6C68_ENST00000548615.1_Missense_Mutation_p.I97V|RP11-110A12.2_ENST00000554049.1_RNA			A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C, member 68	97					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.I102V(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15						TGCATGTGTCATTCAGCTATT	0.358000													7	146					0	0	0.278610	0	0
ZNF347	84671	broad.mit.edu	37	19	53644080	53644080	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:53644080G>C	ENST00000452676.2	-	5	2430	c.2004C>G	c.(2002-2004)caC>caG	p.H668Q	ZNF347_ENST00000601469.2_Missense_Mutation_p.H668Q|ZNF347_ENST00000601804.1_Intron|ZNF347_ENST00000334197.7_Missense_Mutation_p.H667Q	NM_001172674.1	NP_001166145.1	Q96SE7	ZN347_HUMAN	zinc finger protein 347	667					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.H667Q(1)		endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|prostate(3)|skin(1)	23				GBM - Glioblastoma multiforme(134;0.0179)		GTCTTGCAAGGTGTGAATTCT	0.413000													17	140					0	0	0.557998	0	0
ZNF229	7772	broad.mit.edu	37	19	44933924	44933924	+	Silent	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:44933924C>G	ENST00000291187.4	-	6	1336	c.1014G>C	c.(1012-1014)gtG>gtC	p.V338V	CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron|ZNF229_ENST00000588931.1_Silent_p.V344V	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.V344V(1)		breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GCATGTCTCCCACAGGGGCTC	0.498000													6	82					0	0	0.217242	0	0
ZNF623	9831	broad.mit.edu	37	8	144733396	144733396	+	Missense_Mutation	SNP	A	A	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr8:144733396A>T	ENST00000501748.2	+	1	1443	c.1354A>T	c.(1354-1356)Att>Ttt	p.I452F	ZNF623_ENST00000526926.1_Missense_Mutation_p.I412F|ZNF623_ENST00000458270.2_Missense_Mutation_p.I412F	NM_014789.3	NP_055604.3	O75123	ZN623_HUMAN	zinc finger protein 623	452					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.I452F(1)		endometrium(2)|kidney(3)|large_intestine(6)|lung(11)|prostate(1)|stomach(1)|urinary_tract(3)	27	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCACCAGATTATTCACACTGG	0.463000													5	86					0	0	0.184627	0	0
ZNF766	90321	broad.mit.edu	37	19	52794138	52794138	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:52794138G>A	ENST00000439461.1	+	4	1137	c.1094G>A	c.(1093-1095)aGg>aAg	p.R365K	ZNF766_ENST00000593612.1_Missense_Mutation_p.R380K|ZNF766_ENST00000359102.4_Missense_Mutation_p.R380K|ZNF766_ENST00000599581.1_3'UTR|CTD-2525I3.5_ENST00000594865.1_RNA	NM_001010851.2	NP_001010851.1	Q5HY98	ZN766_HUMAN	zinc finger protein 766	365					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R365K(1)		breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	17				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		AAAGCTTTTAGGCACAAGTTC	0.393000													5	21					0	0	0.184627	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37546833	37546833	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr20:37546833G>A	ENST00000299824.1	+	11	1417	c.1228G>A	c.(1228-1230)Gaa>Aaa	p.E410K	PPP1R16B_ENST00000373331.2_Missense_Mutation_p.E368K	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	410					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding	p.E410K(2)		biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				GCTACTCTCCGAATTTCCTAC	0.567000													12	148					0	0	0.457914	0	0
RBMS2	5939	broad.mit.edu	37	12	56975221	56975221	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:56975221G>A	ENST00000262031.5	+	7	756	c.661G>A	c.(661-663)Ggg>Agg	p.G221R	RBMS2_ENST00000542360.1_Missense_Mutation_p.G76R|RBMS2_ENST00000550726.1_Missense_Mutation_p.G96R|RBMS2_ENST00000552247.2_Missense_Mutation_p.G221R	NM_002898.3	NP_002889.1	Q15434	RBMS2_HUMAN	RNA binding motif, single stranded interacting protein 2	221					RNA processing	nucleus	nucleotide binding|RNA binding	p.G221R(1)		breast(1)|endometrium(1)|large_intestine(2)|lung(8)|prostate(3)|skin(2)|urinary_tract(1)	18						TGCTGATGGCGGGCCAAAGAA	0.537000													3	32					0	0	0.115264	0	0
IQCB1	9657	broad.mit.edu	37	3	121544968	121544968	+	Missense_Mutation	SNP	A	A	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr3:121544968A>C	ENST00000310864.6	-	5	537	c.323T>G	c.(322-324)cTt>cGt	p.L108R	IQCB1_ENST00000349820.6_Missense_Mutation_p.L108R	NM_001023570.2	NP_001018864.2	Q15051	IQCB1_HUMAN	IQ motif containing B1	108					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding	p.L108R(1)		NS(1)|biliary_tract(1)|breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)	30				GBM - Glioblastoma multiforme(114;0.0983)		AGCTGATGGAAGTAATTCATT	0.363000													14	27					0	0	0.435327	0	0
TRMT2B	79979	broad.mit.edu	37	X	100274014	100274014	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:100274014G>A	ENST00000338687.7	-	12	2004	c.1199C>T	c.(1198-1200)aCg>aTg	p.T400M	TRMT2B_ENST00000545398.1_Missense_Mutation_p.T445M|TRMT2B_ENST00000372935.1_Missense_Mutation_p.T445M|TRMT2B_ENST00000372931.5_Missense_Mutation_p.T445M|TRMT2B_ENST00000372936.3_Missense_Mutation_p.T445M|TRMT2B_ENST00000372939.1_Missense_Mutation_p.T400M			Q96GJ1	TRM2_HUMAN	tRNA methyltransferase 2 homolog B (S. cerevisiae)	445							tRNA (uracil-5-)-methyltransferase activity	p.T445M(1)		breast(3)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	24						AAAAACTAGCGTGTGGATGGC	0.373000													7	136					0	0	0.307466	0	0
FOXB2	442425	broad.mit.edu	37	9	79634826	79634826	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr9:79634826T>C	ENST00000376708.1	+	1	256	c.256T>C	c.(256-258)Ttc>Ctc	p.F86L		NM_001013735.1	NP_001013757.1	Q5VYV0	FOXB2_HUMAN	forkhead box B2	86					brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding	p.F86L(3)		breast(1)|lung(8)|ovary(1)	10						CAAGGGTAGCTTCTGGGCGCT	0.632000													3	24					0	0	0.150653	0	0
ATG13	9776	broad.mit.edu	37	11	46686502	46686502	+	Missense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr11:46686502C>T	ENST00000434074.1	+	11	1582	c.893C>T	c.(892-894)cCt>cTt	p.P298L	ATG13_ENST00000359513.4_Missense_Mutation_p.P298L|ATG13_ENST00000530500.1_Intron|ATG13_ENST00000529655.1_Intron|ATG13_ENST00000528494.1_Missense_Mutation_p.P331L|ATG13_ENST00000526508.1_Missense_Mutation_p.P298L|ATG13_ENST00000524625.1_Intron|ATG13_ENST00000312040.4_Missense_Mutation_p.P298L|ATG13_ENST00000451945.1_Intron	NM_001205120.1	NP_001192049.1	O75143	ATG13_HUMAN	autophagy related 13	298					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding	p.P331L(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|prostate(1)|skin(1)	15						GCTACACACCCTCACCAGGTA	0.542000													8	153					0	0	0.278610	0	0
STK36	27148	broad.mit.edu	37	2	219563892	219563892	+	Missense_Mutation	SNP	C	C	T	rs142956585		TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr2:219563892C>T	ENST00000295709.3	+	26	3904	c.3625C>T	c.(3625-3627)Cgg>Tgg	p.R1209W	STK36_ENST00000440309.1_Missense_Mutation_p.R1209W|STK36_ENST00000392105.3_Missense_Mutation_p.R1188W|STK36_ENST00000392106.2_Missense_Mutation_p.R1188W	NM_015690.4	NP_056505.2	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	1209					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding	p.R1209W(1)		biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(20)|ovary(4)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	52		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		GGCTGGTATCCGGCGCAATGT	0.592000													4	38					0	0	0.150653	0	0
GIGYF1	64599	broad.mit.edu	37	7	100284038	100284038	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr7:100284038G>C	ENST00000275732.5	-	8	1922	c.713C>G	c.(712-714)gCt>gGt	p.A238G	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	238								p.A238G(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CCGCCAGCCAGCAGAGCGGGG	0.637000													3	38					0	0	0.115264	0	0
THAP6	152815	broad.mit.edu	37	4	76442122	76442122	+	Missense_Mutation	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr4:76442122G>C	ENST00000311638.3	+	3	289	c.221G>C	c.(220-222)aGt>aCt	p.S74T	THAP6_ENST00000508105.1_Missense_Mutation_p.S33T|THAP6_ENST00000504190.1_Missense_Mutation_p.S33T|THAP6_ENST00000502620.1_Missense_Mutation_p.S33T|THAP6_ENST00000514480.1_Missense_Mutation_p.S74T|THAP6_ENST00000507556.1_Missense_Mutation_p.S74T|THAP6_ENST00000507557.1_Missense_Mutation_p.S33T|THAP6_ENST00000380837.3_Missense_Mutation_p.S74T|THAP6_ENST00000507885.1_Missense_Mutation_p.S33T	NM_144721.4	NP_653322.1	Q8TBB0	THAP6_HUMAN	THAP domain containing 6	74						microtubule cytoskeleton	DNA binding|metal ion binding	p.S74T(1)		lung(5)	5			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TTTGACAGAAGTGCTCCAAAT	0.393000													5	73					0	0	0.184627	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74876105	74876105	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr14:74876105C>G	ENST00000331628.3	-	2	590	c.343G>C	c.(343-345)Gtc>Ctc	p.V115L	SYNDIG1L_ENST00000554823.1_Missense_Mutation_p.V115L	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	115					response to biotic stimulus	Golgi apparatus|integral to membrane		p.V115L(1)		breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						TGGATGGTGACATTCTCTGCA	0.597000													16	114					0	0	0.479597	0	0
GUSBP1	728411	broad.mit.edu	37	5	21497235	21497235	+	RNA	SNP	C	C	T	rs141635554	by1000genomes	TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr5:21497235C>T	ENST00000607545.1	+	0	179					NR_027026.1																						AGTTTGAGAACTGGTGTAAGA	0.488000													3	23					0	0	0.184627	0	0
ADCY8	114	broad.mit.edu	37	8	132052081	132052081	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr8:132052081C>G	ENST00000286355.5	-	1	2591	c.499G>C	c.(499-501)Gaa>Caa	p.E167Q	ADCY8_ENST00000377928.3_Missense_Mutation_p.E167Q	NM_001115.2	NP_001106.1	P40145	ADCY8_HUMAN	adenylate cyclase 8 (brain)	167					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding	p.E167Q(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(21)|lung(67)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(5)|urinary_tract(2)	134	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			TAGAGGCGTTCCAAATCCCGA	0.527000										HNSCC(32;0.087)			13	91					0	0	0.479597	0	0
PSTK	118672	broad.mit.edu	37	10	124742438	124742438	+	Missense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr10:124742438C>G	ENST00000405485.1	+	2	472	c.406C>G	c.(406-408)Ctc>Gtc	p.L136V	PSTK_ENST00000368887.3_Missense_Mutation_p.L136V|PSTK_ENST00000497219.1_3'UTR			Q8IV42	PSTK_HUMAN	phosphoseryl-tRNA kinase	136							ATP binding|kinase activity	p.L136V(1)		endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|skin(1)|stomach(2)	13		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0725)		GTCTTGCTACCTCTTAACAAA	0.403000													13	123					0	0	0.500413	0	0
OR51B5	282763	broad.mit.edu	37	11	5363849	5363849	+	Silent	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr11:5363849A>G	ENST00000300773.2	-	1	960	c.906T>C	c.(904-906)ctT>ctC	p.L302L	HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L302L(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAAAAAGGTGAAGAATGGCAT	0.378000													8	75					0	0	0.278610	0	0
TEX26	122046	broad.mit.edu	37	13	31540436	31540436	+	Nonsense_Mutation	SNP	C	C	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr13:31540436C>T	ENST00000380473.3	+	5	560	c.547C>T	c.(547-549)Cga>Tga	p.R183*	TEX26_ENST00000530916.1_Intron	NM_152325.1	NP_689538.1	Q8N6G2	CM026_HUMAN	testis expressed 26	183								p.R183*(2)									CACTGAATTCCGAAGGAATTA	0.423000													7	54					0	0	0.248553	0	0
DLGAP1	9229	broad.mit.edu	37	18	3567562	3567562	+	Missense_Mutation	SNP	T	T	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr18:3567562T>A	ENST00000315677.3	-	9	2578	c.1983A>T	c.(1981-1983)gaA>gaT	p.E661D	DLGAP1_ENST00000400149.3_Missense_Mutation_p.E351D|DLGAP1_ENST00000400150.3_Missense_Mutation_p.E377D|DLGAP1_ENST00000400145.2_Missense_Mutation_p.E359D|DLGAP1_ENST00000400155.1_Missense_Mutation_p.E367D|DLGAP1_ENST00000539435.1_Missense_Mutation_p.E369D|DLGAP1_ENST00000400147.2_Missense_Mutation_p.E359D|DLGAP1_ENST00000581699.1_Missense_Mutation_p.E367D|DLGAP1_ENST00000515196.2_Missense_Mutation_p.E661D|DLGAP1_ENST00000581527.1_Missense_Mutation_p.E661D|DLGAP1_ENST00000534970.1_Missense_Mutation_p.E345D|DLGAP1_ENST00000584874.1_Missense_Mutation_p.E661D	NM_004746.3	NP_004737.2	O14490	DLGP1_HUMAN	discs, large (Drosophila) homolog-associated protein 1	661	Interaction with DYL2 (By similarity).				synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane		p.E369D(1)|p.E661D(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(5)|lung(31)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	56		Colorectal(8;0.0257)				TTTTGTCAGGTTCTTCAGCAT	0.403000													10	94					0	0	0.387290	0	0
SNTG2	54221	broad.mit.edu	37	2	1263181	1263181	+	Missense_Mutation	SNP	C	C	T	rs145354756	by1000genomes	TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr2:1263181C>T	ENST00000308624.5	+	13	1174	c.1045C>T	c.(1045-1047)Cac>Tac	p.H349Y	SNTG2_ENST00000407292.1_Missense_Mutation_p.H222Y	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	349	PH.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding	p.H349Y(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		AAGGACCTATCACCTCTGTGA	0.413000													4	72					0	0	0.150653	0	0
TNNT2	7139	broad.mit.edu	37	1	201333427	201333427	+	Splice_Site	SNP	G	G	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:201333427G>C	ENST00000509001.1	-	10	744	c.459_splice	c.e10+1	p.A153_splice	TNNT2_ENST00000458432.2_Splice_Site_p.A165_splice|TNNT2_ENST00000421663.2_Splice_Site_p.A155_splice|TNNT2_ENST00000367317.4_Splice_Site_p.A153_splice|TNNT2_ENST00000367315.2_Splice_Site_p.A153_splice|TNNT2_ENST00000367318.5_Splice_Site_p.A153_splice|TNNT2_ENST00000367320.2_Splice_Site_p.A123_splice|TNNT2_ENST00000367322.1_Splice_Site_p.A153_splice|TNNT2_ENST00000360372.4_Splice_Site_p.A148_splice|TNNT2_ENST00000236918.7_Splice_Site_p.A158_splice	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	163					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding	p.A153G(1)		breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						GTCACTCACAGCCAGGCGGTT	0.637000													2	7					0	0	0.115264	0	0
NTN4	59277	broad.mit.edu	37	12	96059736	96059736	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr12:96059736A>G	ENST00000343702.4	-	9	2048	c.1600T>C	c.(1600-1602)Tca>Cca	p.S534P	NTN4_ENST00000538383.1_Missense_Mutation_p.S497P|NTN4_ENST00000553059.1_Missense_Mutation_p.S511P|PGAM1P5_ENST00000552554.1_RNA|NTN4_ENST00000344911.4_Missense_Mutation_p.S497P	NM_021229.3	NP_067052.2	Q9HB63	NET4_HUMAN	netrin 4	534	NTR.				axon guidance	basement membrane|plasma membrane		p.S534P(1)		NS(2)|breast(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	25						TCATGAGCTGATAAAATCTTT	0.303000													6	60					0	0	0.248553	0	0
MET	4233	broad.mit.edu	37	7	116412024	116412024	+	Nonsense_Mutation	SNP	C	C	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr7:116412024C>G	ENST00000397752.3	+	14	3209	c.3009C>G	c.(3007-3009)taC>taG	p.Y1003*	MET_ENST00000318493.6_Nonsense_Mutation_p.Y1021*	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	1003					axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding	p.L982_D1028del(3)|p.D981_D1028del(1)|p.982_1028del47(1)|p.?(1)|p.Y1021*(1)		NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			CTGTAGACTACCGAGCTACTT	0.383000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				6	34					0	0	0.248553	0	0
AKAP4	8852	broad.mit.edu	37	X	49955748	49955748	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:49955748A>G	ENST00000376056.2	-	6	2543	c.2393T>C	c.(2392-2394)gTt>gCt	p.V798A	AKAP4_ENST00000481402.1_5'UTR|AKAP4_ENST00000358526.2_Missense_Mutation_p.V807A|AKAP4_ENST00000376058.2_Missense_Mutation_p.V424A|AKAP4_ENST00000376064.3_Missense_Mutation_p.V798A			Q5JQC9	AKAP4_HUMAN	A kinase (PRKA) anchor protein 4	807					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding	p.V807A(1)		NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(6)|lung(14)|ovary(1)|skin(4)	41	Ovarian(276;0.236)					TTTAGCTGAAACCTGAGGAAG	0.507000													7	130					0	0	0.278610	0	0
ZNF544	27300	broad.mit.edu	37	19	58757682	58757682	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:58757682G>A	ENST00000599227.1	+	5	633	c.49G>A	c.(49-51)Gag>Aag	p.E17K	ZNF544_ENST00000595981.1_Missense_Mutation_p.E17K|ZNF544_ENST00000415203.2_Missense_Mutation_p.E17K|ZNF544_ENST00000596929.1_Missense_Mutation_p.E17K|ZNF544_ENST00000599953.1_Intron|ZNF544_ENST00000596597.1_3'UTR|CTD-3138B18.4_ENST00000600029.1_Missense_Mutation_p.E17K|ZNF544_ENST00000600220.1_Missense_Mutation_p.E17K|ZNF544_ENST00000600044.1_Missense_Mutation_p.E17K|ZNF544_ENST00000596825.1_Missense_Mutation_p.E17K|ZNF544_ENST00000594384.1_Missense_Mutation_p.E17K|ZNF544_ENST00000596652.1_Missense_Mutation_p.E17K|ZNF544_ENST00000333581.5_Missense_Mutation_p.E17K|ZNF544_ENST00000269829.4_Missense_Mutation_p.E17K			Q6NX49	ZN544_HUMAN	zinc finger protein 544	17	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.E17K(1)		NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TGTGTGCTTCGAGGATGTGGC	0.552000													13	223					0	0	0.435327	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64722914	64722914	+	Missense_Mutation	SNP	T	T	C			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:64722914T>C	ENST00000338957.4	+	5	2403	c.2336T>C	c.(2335-2337)aTg>aCg	p.M779T	ZC3H12B_ENST00000423889.3_Missense_Mutation_p.M768T	NM_001010888.3	NP_001010888.3	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	768							endonuclease activity|nucleic acid binding|zinc ion binding	p.M715T(1)|p.M629T(1)		breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TGGGTTGGAATGTGCAATGAT	0.478000													13	76					0	0	0.411799	0	0
AMOT	154796	broad.mit.edu	37	X	112024327	112024327	+	Missense_Mutation	SNP	G	G	T			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chrX:112024327G>T	ENST00000371959.3	-	9	2259	c.2260C>A	c.(2260-2262)Cag>Aag	p.Q754K	AMOT_ENST00000371962.1_Missense_Mutation_p.Q522K|AMOT_ENST00000371958.1_Missense_Mutation_p.Q522K|AMOT_ENST00000524145.1_Missense_Mutation_p.Q754K|AMOT_ENST00000304758.1_Missense_Mutation_p.Q345K	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	754					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity	p.Q345K(1)|p.Q754K(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						TCAATAATCTGGGCATGGAGG	0.532000													13	162					4.36969e-10	5.07448e-10	0.435327	1	0
ZNF8	7554	broad.mit.edu	37	19	58805974	58805974	+	Missense_Mutation	SNP	A	A	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr19:58805974A>G	ENST00000196548.5	+	4	931	c.800A>G	c.(799-801)aAc>aGc	p.N267S	AC010642.1_ENST00000591325.1_3'UTR	NM_021089.2	NP_066575.2	P17098	ZNF8_HUMAN	zinc finger protein 8	267					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.N267S(1)		autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	19		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		AAGTCGTTTAACCATAACGCA	0.488000													7	29					0	0	0.248553	0	0
FGFR1OP	11116	broad.mit.edu	37	6	167417806	167417806	+	Missense_Mutation	SNP	G	G	A			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr6:167417806G>A	ENST00000366847.3	+	5	586	c.355G>A	c.(355-357)Gca>Aca	p.A119T	FGFR1OP_ENST00000349556.4_Missense_Mutation_p.A119T	NM_007045.2	NP_008976.1	O95684	FR1OP_HUMAN	FGFR1 oncogene partner	119					G2/M transition of mitotic cell cycle|microtubule anchoring|positive regulation of cell growth|positive regulation of cell migration|positive regulation of cell proliferation	centrosome|cytosol|nucleus|perinuclear region of cytoplasm	protein homodimerization activity|protein kinase binding|protein tyrosine kinase inhibitor activity	p.A119T(1)		large_intestine(2)|ovary(1)|stomach(1)	4		Breast(66;1.48e-05)|Ovarian(120;0.0607)		OV - Ovarian serous cystadenocarcinoma(33;1.73e-19)|BRCA - Breast invasive adenocarcinoma(81;5.1e-06)|GBM - Glioblastoma multiforme(31;0.00231)		TATAATTGAAGCAGAAGGTAC	0.413000			T	FGFR1	"""MPD, NHL"""								11	43					0	0	0.361761	0	0
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121137803	121137805	+	RNA	DEL	CCA	CCA	-	rs60375635	by1000genomes	TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr1:121137803_121137805delCCA	ENST00000437515.1	-	0	329																											ACCGCCGCCGCCACGGCTTTTTG	0.645													2	4	---	---	---	---					
MUC20	200958	broad.mit.edu	37	3	195447912	195447914	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr3:195447912_195447914delTTC	ENST00000320736.6	+	1	160_162	c.34_36delTTC	c.(34-36)del	p.F14del	MUC20_ENST00000485430.1_3'UTR|MUC20_ENST00000436408.1_In_Frame_Del_p.F14del|MUC20_ENST00000447234.2_In_Frame_Del_p.F14del	NM_001098516.1|NM_152673.2	NP_001091986.1|NP_689886.2	Q8N307	MUC20_HUMAN	mucin 20, cell surface associated	14					protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		TCTGCCCCTTTTCTTCTTCTGCT	0.611													4	3	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396278	+	RNA	INS	-	-	T	rs148140777	by1000genomes	TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr10:118396277_118396278insT	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000298771.7_RNA|PNLIPRP2_ENST00000433618.4_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTTT	0.421													4	3	---	---	---	---					
PHLDA2	7262	broad.mit.edu	37	11	2950237	2950238	+	Frame_Shift_Ins	INS	-	-	G			TCGA-75-6205-01A-11D-1753-08	TCGA-75-6205-10A-01D-1753-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	79c0e183-95aa-4c37-9b15-8567aa87c93a	e5c1b4a8-e9f1-40c0-a1ef-58a184918b2c	g.chr11:2950237_2950238insG	ENST00000314222.4	-	1	447_448	c.357_358insC	c.(355-360)ccccgcfs	p.R120fs		NM_003311.3	NP_003302.1	Q53GA4	PHLA2_HUMAN	pleckstrin homology-like domain, family A, member 2	120					apoptosis	cytoplasm|membrane				central_nervous_system(1)	1		all_epithelial(84;0.000124)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)|all_lung(207;0.198)		BRCA - Breast invasive adenocarcinoma(625;0.0025)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCGGGTGCGGCGGGTGCGGTGC	0.743													2	4	---	---	---	---					
