Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OGFOD3	79701	broad.mit.edu	37	17	80361813	80361813	+	Splice_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:80361813C>A	ENST00000313056.5	-	7	850	c.699_splice	c.e7+1	p.K233_splice	OGFOD3_ENST00000329197.5_Splice_Site_p.K233_splice	NM_024648.2|NM_175902.4	NP_078924.1|NP_787098.3			2-oxoglutarate and iron-dependent oxygenase domain containing 3																		GCGCGCTCACCTTGTCCACGT	0.677000													9	14					1.58986e-06	2.77437e-06	0.008291	1	0
EGR1	1958	broad.mit.edu	37	5	137802542	137802542	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:137802542G>T	ENST00000239938.4	+	2	676	c.404G>T	c.(403-405)gGc>gTc	p.G135V		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	135					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACCTATACTGGCCGCTTTTCC	0.582000													86	50					1.46381e-53	4.08162e-53	0.014410	1	0
CPQ	10404	broad.mit.edu	37	8	97797326	97797326	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:97797326G>A	ENST00000220763.5	+	2	411	c.201G>A	c.(199-201)ttG>ttA	p.L67L		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	67					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										ATGAGCGATTGGCACTTCTGG	0.438000													50	97					0	0	0.014410	0	0
ZNF607	84775	broad.mit.edu	37	19	38202555	38202555	+	Translation_Start_Site	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:38202555G>A	ENST00000355202.4	-	0	560				ZNF607_ENST00000395835.3_De_novo_Start_OutOfFrame|CTD-2528L19.4_ENST00000586606.2_De_novo_Start_OutOfFrame	NM_032689.4	NP_116078.4	Q96SK3	ZN607_HUMAN	zinc finger protein 607						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(11)|lung(8)|urinary_tract(1)	27			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			AGTCCTTGGCGTTTCTCTACC	0.438000													15	47					0	0	0.002450	0	0
PCDHGB1	56104	broad.mit.edu	37	5	140731926	140731926	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:140731926T>A	ENST00000523390.1	+	1	2099	c.2099T>A	c.(2098-2100)cTc>cAc	p.L700H	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGCTCTTTCTCCTCGCGGTG	0.607000													159	93					0	0	0.014410	0	0
WDR66	144406	broad.mit.edu	37	12	122396894	122396894	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:122396894T>C	ENST00000288912.4	+	13	2881	c.2027T>C	c.(2026-2028)cTt>cCt	p.L676P	WDR66_ENST00000397454.2_Missense_Mutation_p.L676P	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	676							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GTTTACATTCTTGATGCAATG	0.418000													60	118					0	0	0.014410	0	0
ADCY10	55811	broad.mit.edu	37	1	167830185	167830185	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:167830185G>A	ENST00000367848.1	-	15	1954	c.1457C>T	c.(1456-1458)aCc>aTc	p.T486I	ADCY10_ENST00000545172.1_Missense_Mutation_p.T425I|ADCY10_ENST00000367851.4_Missense_Mutation_p.T578I			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	578					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						TCGAAGGTTGGTCTGTCGTTC	0.363000													31	213					0	0	0.012213	0	0
AFM	173	broad.mit.edu	37	4	74357672	74357672	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:74357672G>A	ENST00000226355.3	+	8	1020	c.927G>A	c.(925-927)gaG>gaA	p.E309E		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	309	Albumin 2.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AAATACCAGAGCGCGGCCAGT	0.353000													33	68					0	0	0.010818	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222535	140222535	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:140222535G>T	ENST00000531613.1	+	1	1629	c.1629G>T	c.(1627-1629)ccG>ccT	p.P543P	PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA8_ENST00000378123.3_Silent_p.P543P|PCDHA5_ENST00000529859.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGGCGTGCCGCCTCTGGGCA	0.687000													125	47					1.22322e-63	3.50345e-63	0.014410	1	0
BOLL	66037	broad.mit.edu	37	2	198646503	198646503	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:198646503G>A	ENST00000321801.7	-	2	678	c.108C>T	c.(106-108)gcC>gcT	p.A36A	BOLL_ENST00000433157.1_Silent_p.A24A|BOLL_ENST00000392296.4_Silent_p.A24A|BOLL_ENST00000282278.8_5'UTR|BOLL_ENST00000430004.1_Silent_p.A24A	NM_197970.2	NP_932074.1	Q8N9W6	BOLL_HUMAN	boule-like RNA-binding protein	24	RRM.				cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	nucleotide binding|protein binding|RNA binding|translation activator activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(3)|prostate(1)	13						CATATCTTGGGGCACTTGTTG	0.368000													83	203					0	0	0.014410	0	0
KLK3	354	broad.mit.edu	37	19	51361318	51361318	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:51361318G>T	ENST00000360617.3	+	3	240	c.240G>T	c.(238-240)ctG>ctT	p.L80L	KLK3_ENST00000595952.1_Intron|KLK3_ENST00000593997.1_Silent_p.L80L|KLK3_ENST00000326003.2_Silent_p.L80L|KLK3_ENST00000597483.1_Intron			P07288	KLK3_HUMAN	kallikrein-related peptidase 3	80	Peptidase S1.				negative regulation of angiogenesis|proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00763)|GBM - Glioblastoma multiforme(134;0.0144)		GGCACAGCCTGTTTCATCCTG	0.547000													20	55					1.2644e-06	2.22138e-06	0.010504	1	0
SNTG1	54212	broad.mit.edu	37	8	51465741	51465741	+	Splice_Site	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:51465741T>A	ENST00000522124.1	+	12	1471		c.e12+2		SNTG1_ENST00000517473.1_Splice_Site|SNTG1_ENST00000518864.1_Splice_Site|SNTG1_ENST00000276467.5_Splice_Site	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1						cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				AAGCACAATGTAAGTAATGAT	0.408000													29	42					0	0	0.010818	0	0
NRXN1	9378	broad.mit.edu	37	2	51255149	51255149	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:51255149C>A	ENST00000404971.1	-	2	1602	c.263G>T	c.(262-264)cGc>cTc	p.R88L	NRXN1_ENST00000406859.3_Missense_Mutation_p.R88L|NRXN1_ENST00000401669.2_Missense_Mutation_p.R88L|NRXN1_ENST00000406316.2_Missense_Mutation_p.R88L|NRXN1_ENST00000405581.1_Missense_Mutation_p.R88L|NRXN1_ENST00000405472.3_Missense_Mutation_p.R88L|NRXN1_ENST00000402717.3_Missense_Mutation_p.R88L	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	88	Laminin G-like 1.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAGCTGCAGGCGGCCGCCGCG	0.677000													13	31					0.000219431	0.000373033	0.002450	1	0
EHMT2	10919	broad.mit.edu	37	6	31852716	31852716	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:31852716C>T	ENST00000395728.3	-	18	2591	c.2592G>A	c.(2590-2592)cgG>cgA	p.R864R	EHMT2_ENST00000375528.4_Silent_p.R830R|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375530.4_Silent_p.R773R|EHMT2_ENST00000375537.4_Silent_p.R807R			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	807					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding	p.R807R(1)		central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						CGTCGGCGCCCCGCGTCAGTA	0.637000													19	49					0	0	0.007413	0	0
PSG11	5680	broad.mit.edu	37	19	43519364	43519364	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:43519364G>T	ENST00000401740.1	-	4	971	c.868C>A	c.(868-870)Cag>Aag	p.Q290K	PSG11_ENST00000320078.7_Missense_Mutation_p.Q290K|PSG11_ENST00000306322.7_Missense_Mutation_p.Q168K|PSG11_ENST00000403486.1_Missense_Mutation_p.Q168K			Q9UQ72	PSG11_HUMAN	pregnancy specific beta-1-glycoprotein 11	290	Ig-like C2-type 2.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	26		Prostate(69;0.00682)				GGAGTAATCTGAGGGATAAAG	0.463000													73	269					5.32961e-40	1.37682e-39	0.014410	1	0
SLC6A10P	386757	broad.mit.edu	37	16	32891042	32891042	+	RNA	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:32891042C>A	ENST00000330048.5	-	0	2925					NR_003083.2																						ACATCCCACCCTGGGGGACAG	0.602000													68	77					2.40982e-25	5.47402e-25	0.014410	1	0
LILRA4	23547	broad.mit.edu	37	19	54848199	54848199	+	Missense_Mutation	SNP	C	C	G	rs143168076		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:54848199C>G	ENST00000291759.4	-	6	1224	c.1168G>C	c.(1168-1170)Gcg>Ccg	p.A390P	AC008984.2_ENST00000507363.1_RNA	NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	390	Ig-like C2-type 4.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TAGGTCCCCGCGTGGGCTGAG	0.622000													115	254					0	0	0.014410	0	0
GPR115	221393	broad.mit.edu	37	6	47681561	47681561	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:47681561C>A	ENST00000283303.2	+	6	838	c.580C>A	c.(580-582)Ctc>Atc	p.L194I	GPR115_ENST00000327753.3_Missense_Mutation_p.L194I|GPR115_ENST00000371220.1_Missense_Mutation_p.L251I	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	194					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						CAACCACATCCTCGACACAGC	0.413000													59	63					7.82978e-24	1.75587e-23	0.014410	1	0
CHN1	1123	broad.mit.edu	37	2	175677163	175677163	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:175677163C>T	ENST00000409900.3	-	9	1073	c.760G>A	c.(760-762)Gac>Aac	p.D254N	CHN1_ENST00000409156.3_Missense_Mutation_p.D228N|CHN1_ENST00000409597.1_Missense_Mutation_p.D70N|CHN1_ENST00000488080.1_5'UTR|CHN1_ENST00000295497.7_Missense_Mutation_p.D129N	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	254					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			GGCTTACAGTCATTTGGGACC	0.398000			T	TAF15	extraskeletal myxoid chondrosarcoma								105	88					0	0	0.014410	0	0
SNHG14	104472715	broad.mit.edu	37	15	25446384	25446384	+	RNA	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:25446384C>A	ENST00000424208.1	+	0	1959				SNHG14_ENST00000424333.1_RNA	NR_003305.1																						CATGCCCTTCCTGGTGCCCTA	0.592000													35	118					1.45844e-13	2.87863e-13	0.013726	1	0
LPA	4018	broad.mit.edu	37	6	161007518	161007518	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:161007518C>A	ENST00000447678.1	-	26	4212	c.4092G>T	c.(4090-4092)gtG>gtT	p.V1364V	LPA_ENST00000316300.5_Silent_p.V1364V	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3872	Kringle 12.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GAACTGGGACCACCGTGGGAG	0.493000													32	108					4.34311e-12	8.41477e-12	0.003271	1	0
RBBP8NL	140893	broad.mit.edu	37	20	60985978	60985978	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:60985978C>A	ENST00000252998.1	-	14	2107	c.1951G>T	c.(1951-1953)Gac>Tac	p.D651Y		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		GGACTGTGGTCCTCGGCGTCC	0.677000													76	85					1.24833e-42	3.35649e-42	0.014410	1	0
ZNF831	128611	broad.mit.edu	37	20	57768321	57768321	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:57768321C>A	ENST00000371030.2	+	1	2247	c.2247C>A	c.(2245-2247)gtC>gtA	p.V749V		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	749						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCCCCCTGGTCTCTCCAAATG	0.642000													12	9					0.000978159	0.00164169	0.010729	1	0
SELE	6401	broad.mit.edu	37	1	169698396	169698396	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:169698396A>T	ENST00000333360.7	-	7	1160	c.1021T>A	c.(1021-1023)Ttg>Atg	p.L341M	SELE_ENST00000367774.1_Missense_Mutation_p.L341M|SELE_ENST00000367780.4_Missense_Mutation_p.L279M|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367781.4_Missense_Mutation_p.L341M|SELE_ENST00000367779.4_Missense_Mutation_p.L341M|SELE_ENST00000367777.1_Missense_Mutation_p.L341M|SELE_ENST00000367776.1_Missense_Mutation_p.L341M|SELE_ENST00000367775.1_Missense_Mutation_p.L279M|SELE_ENST00000367782.4_Missense_Mutation_p.L341M	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	341	Sushi 3.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					GGTCCCTGCAACATGAAGCCT	0.517000													63	80					0	0	0.014410	0	0
EN1	2019	broad.mit.edu	37	2	119600786	119600786	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:119600786C>G	ENST00000295206.6	-	2	1417	c.907G>C	c.(907-909)Gac>Cac	p.D303H		NM_001426.3	NP_001417.3	Q05925	HME1_HUMAN	engrailed homeobox 1	303					skeletal system development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	9						GGCCGCTTGTCCTCCTTCTCG	0.677000													8	19					0	0	0.003080	0	0
KRT37	8688	broad.mit.edu	37	17	39578346	39578346	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:39578346A>T	ENST00000225550.3	-	5	994	c.995T>A	c.(994-996)gTg>gAg	p.V332E	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	332	Coil 2.|Rod.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				TTGGCGCTCCACCTCCAGGGC	0.582000													32	126					0	0	0.003271	0	0
BLM	641	broad.mit.edu	37	15	91341491	91341491	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:91341491A>G	ENST00000355112.3	+	17	3400	c.3282A>G	c.(3280-3282)tcA>tcG	p.S1094S	BLM_ENST00000560509.1_Silent_p.S1094S|BLM_ENST00000560136.1_3'UTR	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	1094					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			ATAGTTCATCACAAGGAATGA	0.318000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				62	79					0	0	0.014410	0	0
FAM83H	286077	broad.mit.edu	37	8	144808765	144808765	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:144808765T>A	ENST00000388913.3	-	5	2991	c.2866A>T	c.(2866-2868)Agc>Tgc	p.S956C		NM_198488.3	NP_940890.3	Q6ZRV2	FA83H_HUMAN	family with sequence similarity 83, member H	956					biomineral tissue development					central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(12)|pancreas(1)|prostate(3)|urinary_tract(1)	21	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			ATGGGGCCGCTCGGCCCCTCC	0.711000													18	34					0	0	0.007413	0	0
SYN3	8224	broad.mit.edu	37	22	32914053	32914053	+	Silent	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:32914053T>A	ENST00000358763.2	-	13	1829	c.1587A>T	c.(1585-1587)ccA>ccT	p.P529P	SYN3_ENST00000467095.1_5'UTR|SYN3_ENST00000332840.5_Silent_p.P529P	NM_001135774.1	NP_001129246.1	O14994	SYN3_HUMAN	synapsin III	529	J; Pro-rich linker.				neurotransmitter secretion	cell junction|synaptic vesicle membrane	ATP binding|ligase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33						GGGGTGGTGCTGGCTTCTTGG	0.592000													70	55					0	0	0.014410	0	0
ALPK3	57538	broad.mit.edu	37	15	85401453	85401453	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:85401453G>C	ENST00000258888.5	+	6	4257	c.4090G>C	c.(4090-4092)Ggg>Cgg	p.G1364R		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1364			G -> E (in a metastatic melanoma sample; somatic mutation).		heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACTGGCTCTAGGGGCCCGGAG	0.627000													11	18					0	0	0.013537	0	0
IL17RD	54756	broad.mit.edu	37	3	57130439	57130439	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:57130439G>A	ENST00000296318.7	-	13	2290	c.2202C>T	c.(2200-2202)caC>caT	p.H734H	IL17RD_ENST00000463523.1_Silent_p.H590H|IL17RD_ENST00000427856.2_Silent_p.H710H|IL17RD_ENST00000320057.5_Silent_p.H590H	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	734						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		GGGCGACCGCGTGGAGTTCAT	0.547000													116	65					0	0	0.014410	0	0
FOXM1	2305	broad.mit.edu	37	12	2975569	2975569	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:2975569T>A	ENST00000342628.2	-	5	1078	c.965A>T	c.(964-966)cAg>cTg	p.Q322L	FOXM1_ENST00000537018.1_5'UTR|FOXM1_ENST00000361953.3_Missense_Mutation_p.Q322L|FOXM1_ENST00000359843.3_Missense_Mutation_p.Q322L	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	322					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			CTTAAACACCTGGTCCAATGT	0.498000													79	92					0	0	0.014410	0	0
PXDNL	137902	broad.mit.edu	37	8	52359687	52359687	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:52359687G>A	ENST00000356297.4	-	12	1502	c.1402C>T	c.(1402-1404)Ctc>Ttc	p.L468F	PXDNL_ENST00000543296.1_Missense_Mutation_p.L468F	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	468	Ig-like C2-type 3.				hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CCAGAGGAGAGAACTGTATGC	0.507000													33	228					0	0	0.009535	0	0
DNAJA3	9093	broad.mit.edu	37	16	4494686	4494686	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:4494686T>A	ENST00000262375.6	+	7	1030	c.953T>A	c.(952-954)gTg>gAg	p.V318E	DNAJA3_ENST00000355296.4_Missense_Mutation_p.V318E|DNAJA3_ENST00000431375.2_Missense_Mutation_p.V165E	NM_005147.5	NP_005138.3	Q96EY1	DNJA3_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 3	318					activation of caspase activity|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of cell proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein kinase activity|neuromuscular junction development|positive regulation of apoptosis|positive regulation of protein ubiquitination|protein folding|protein stabilization|response to heat|response to interferon-gamma	cytosol|mitochondrial matrix|mitochondrial nucleoid|nucleus	ATP binding|heat shock protein binding|interferon-gamma receptor binding|metal ion binding|NF-kappaB binding|protein kinase binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|ovary(2)|upper_aerodigestive_tract(2)	15						GGCCAGACCGTGAGGATGCCT	0.567000													13	55					0	0	0.002450	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140869611	140869611	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:140869611T>A	ENST00000252087.1	+	1	804	c.804T>A	c.(802-804)gaT>gaA	p.D268E	PCDHGB7_ENST00000398594.2_Intron|PCDHGA10_ENST00000398610.2_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB6_ENST00000520790.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGC4_ENST00000306593.1_Intron|PCDHGA12_ENST00000252085.3_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGC3_ENST00000308177.3_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA11_ENST00000518882.1_Intron	NM_018929.2|NM_032403.2|NM_032407.1	NP_061752.1|NP_115779.1|NP_115783.1	Q9Y5F6	PCDGM_HUMAN		268	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCCACTGATCCAGACGAGG	0.527000													166	83					0	0	0.014410	0	0
PTPRS	5802	broad.mit.edu	37	19	5225821	5225821	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:5225821G>C	ENST00000372412.4	-	17	2647	c.2414C>G	c.(2413-2415)gCg>gGg	p.A805G	PTPRS_ENST00000588552.1_Intron|PTPRS_ENST00000592099.1_Intron|PTPRS_ENST00000357368.4_Missense_Mutation_p.A804G|PTPRS_ENST00000588012.1_Missense_Mutation_p.A782G|PTPRS_ENST00000587303.1_Missense_Mutation_p.A804G|PTPRS_ENST00000348075.2_Missense_Mutation_p.A782G|PTPRS_ENST00000262963.6_Missense_Mutation_p.A800G|PTPRS_ENST00000353284.2_Intron			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	804	Fibronectin type-III 5.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GATGGAGTACGCGGTCTCAGG	0.647000													24	30					0	0	0.002780	0	0
UGT2B7	7364	broad.mit.edu	37	4	69962246	69962246	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:69962246T>C	ENST00000305231.7	+	1	54	c.8T>C	c.(7-9)gTg>gCg	p.V3A	UGT2B7_ENST00000508661.1_Missense_Mutation_p.V3A|UGT2B7_ENST00000509763.1_Intron	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	3					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AGGATGTCTGTGAAATGGACT	0.408000													39	82					0	0	0.006999	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	73969507	73969507	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:73969507C>T	ENST00000476977.1	+	18	3611	c.1920C>T	c.(1918-1920)ccC>ccT	p.P640P	GTF2IRD1_ENST00000265755.3_Silent_p.P640P|GTF2IRD1_ENST00000455841.2_Silent_p.P672P|GTF2IRD1_ENST00000489094.1_3'UTR|GTF2IRD1_ENST00000424337.2_Silent_p.P640P			Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1	640						nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(19)|ovary(6)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TTTCCAGGCCCGAGCTGCTCA	0.622000													14	137					0	0	0.004007	0	0
MPDZ	8777	broad.mit.edu	37	9	13192152	13192152	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:13192152C>G	ENST00000319217.7	-	15	2193	c.1946G>C	c.(1945-1947)tGt>tCt	p.C649S	MPDZ_ENST00000541718.1_Missense_Mutation_p.C649S|MPDZ_ENST00000447879.1_Missense_Mutation_p.C649S|MPDZ_ENST00000536827.1_Missense_Mutation_p.C649S|MPDZ_ENST00000381015.4_Missense_Mutation_p.C649S|MPDZ_ENST00000381022.2_Missense_Mutation_p.C649S|MPDZ_ENST00000546205.1_Missense_Mutation_p.C649S	NM_001261406.1	NP_001248335.1	O75970	MPDZ_HUMAN	multiple PDZ domain protein	649					interspecies interaction between organisms	apical plasma membrane|dendrite|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	protein C-terminus binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(15)|ovary(5)|prostate(7)|stomach(1)|urinary_tract(2)	61				GBM - Glioblastoma multiforme(50;2.03e-06)		CTCAATATCACATAAGTCCAG	0.378000													7	8					0	0	0.001984	0	0
OR10G4	390264	broad.mit.edu	37	11	123886668	123886668	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:123886668C>A	ENST00000320891.4	+	1	387	c.387C>A	c.(385-387)ctC>ctA	p.L129L		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	129					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GTTACCCGCTCAGGTACACCA	0.552000													51	239					6.2918e-36	1.57894e-35	0.014410	1	0
GPRC6A	222545	broad.mit.edu	37	6	117130692	117130692	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:117130692G>T	ENST00000310357.3	-	2	304	c.283C>A	c.(283-285)Ctg>Atg	p.L95M	GPRC6A_ENST00000368549.3_Missense_Mutation_p.L95M|GPRC6A_ENST00000530250.1_Missense_Mutation_p.L95M	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	95					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TCATACCCCAGTTTGACTCCA	0.408000													17	47					8.60227e-14	1.71072e-13	0.004007	1	0
ECM2	1842	broad.mit.edu	37	9	95284981	95284981	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:95284981C>T	ENST00000344604.5	-	2	317	c.168G>A	c.(166-168)caG>caA	p.Q56Q	CENPP_ENST00000375587.3_Intron|ECM2_ENST00000444490.2_Silent_p.Q56Q|ECM2_ENST00000375540.1_Silent_p.Q56Q	NM_001197295.1|NM_001393.3	NP_001184224.1|NP_001384.1	O94769	ECM2_HUMAN	extracellular matrix protein 2, female organ and adipocyte specific	56			Q -> P (in dbSNP:rs10120210).		cell-matrix adhesion		integrin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27						CTGTTGTTTGCTGAATTCCAA	0.388000													75	78					0	0	0.014410	0	0
CPNE6	9362	broad.mit.edu	37	14	24546540	24546540	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr14:24546540C>A	ENST00000397016.2	+	16	1788	c.1477C>A	c.(1477-1479)Cga>Aga	p.R493R	CPNE6_ENST00000216775.2_Silent_p.R493R|CPNE6_ENST00000537691.1_Silent_p.R548R			O95741	CPNE6_HUMAN	copine VI (neuronal)	493	VWFA.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			endometrium(4)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	22				GBM - Glioblastoma multiforme(265;0.0184)		GCGCTGCCCCCGAGGGGTGCC	0.647000													57	30					1.3268e-25	3.02695e-25	0.014410	1	0
PCCA	5095	broad.mit.edu	37	13	100953772	100953772	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:100953772G>C	ENST00000376285.1	+	13	1162	c.1124G>C	c.(1123-1125)cGt>cCt	p.R375P	PCCA_ENST00000376279.3_Missense_Mutation_p.R375P|PCCA_ENST00000376286.4_Missense_Mutation_p.R349P	NM_000282.3	NP_000273.2	P05165	PCCA_HUMAN	propionyl CoA carboxylase, alpha polypeptide	375	ATP-grasp.|Biotin carboxylation.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|prostate(1)|skin(2)	26	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	GAAATGATCCGTGTTGCTAAG	0.502000													47	212					0	0	0.014410	0	0
CFHR5	81494	broad.mit.edu	37	1	196971705	196971705	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:196971705C>T	ENST00000367414.5	+	8	1369	c.1313C>T	c.(1312-1314)gCt>gTt	p.A438V	CFHR5_ENST00000256785.4_Missense_Mutation_p.A414V	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	414	Sushi 7.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						GAAAAAGTAGCTGTTCTCTGT	0.388000													43	48					0	0	0.007835	0	0
CA1	759	broad.mit.edu	37	8	86249258	86249258	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:86249258C>G	ENST00000523953.1	-	5	1316	c.270G>C	c.(268-270)agG>agC	p.R90S	CA1_ENST00000432364.2_Missense_Mutation_p.R90S|CA1_ENST00000542576.1_Missense_Mutation_p.R90S|CA1_ENST00000256119.5_Missense_Mutation_p.R90S|CA1_ENST00000523022.1_Missense_Mutation_p.R90S|CA1_ENST00000431316.1_Missense_Mutation_p.R90S|CA1_ENST00000518341.1_5'UTR|CA1_ENST00000522389.1_Intron			P00915	CAH1_HUMAN	carbonic anhydrase I	90					one-carbon metabolic process	Golgi apparatus	carbonate dehydratase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	13		all_lung(136;4.89e-06)			Acetazolamide(DB00819)|Amlodipine(DB00381)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dichlorphenamide(DB01144)|Ethinamate(DB01031)|Ethoxzolamide(DB00311)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Levetiracetam(DB01202)|Methazolamide(DB00703)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)|Verapamil(DB00661)|Zonisamide(DB00909)	ACTGAAAGAGCCTGTAGCTGT	0.423000													72	106					0	0	0.014410	0	0
OR6C1	390321	broad.mit.edu	37	12	55714896	55714896	+	Silent	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:55714896T>A	ENST00000379668.2	+	1	551	c.513T>A	c.(511-513)atT>atA	p.I171I		NM_001005182.1	NP_001005182.1	Q96RD1	OR6C1_HUMAN	olfactory receptor, family 6, subfamily C, member 1	171					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(5)|liver(2)|lung(13)|ovary(1)|upper_aerodigestive_tract(1)	25						GGTCTAATATTATTGACCATT	0.373000													31	78					0	0	0.009535	0	0
PSPC1	55269	broad.mit.edu	37	13	20283715	20283715	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:20283715C>A	ENST00000338910.4	-	7	1342	c.1183G>T	c.(1183-1185)Gat>Tat	p.D395Y		NM_001042414.2	NP_001035879.1	Q8WXF1	PSPC1_HUMAN	paraspeckle component 1	395	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		GGACCCATATCACCCATTCTC	0.383000													113	56					1.46925e-46	4.01188e-46	0.014410	1	0
KHDRBS2	202559	broad.mit.edu	37	6	62757835	62757835	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:62757835G>T	ENST00000281156.4	-	3	562	c.284C>A	c.(283-285)aCa>aAa	p.T95K		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	95	KH.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		TTTAGCACCTGTTTCTTCCTG	0.378000													52	99					2.0833e-19	4.53677e-19	0.014410	1	0
OR10G7	390265	broad.mit.edu	37	11	123908791	123908791	+	Silent	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:123908791T>C	ENST00000330487.5	-	1	926	c.918A>G	c.(916-918)gtA>gtG	p.V306V		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CCTGAGCAAATACTGACCCAT	0.353000													36	47					0	0	0.006230	0	0
OR4A15	81328	broad.mit.edu	37	11	55136137	55136137	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:55136137G>T	ENST00000314706.3	+	1	778	c.778G>T	c.(778-780)Ggg>Tgg	p.G260W		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						GAGTTTGGAAGGGAAACGAAA	0.428000													97	107					2.42943e-58	6.84659e-58	0.014410	1	0
OR13C8	138802	broad.mit.edu	37	9	107331760	107331760	+	Silent	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:107331760T>A	ENST00000335040.1	+	1	312	c.312T>A	c.(310-312)tcT>tcA	p.S104S		NM_001004483.1	NP_001004483.1	Q8NGS7	O13C8_HUMAN	olfactory receptor, family 13, subfamily C, member 8	104					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|skin(1)	25						TGTTTATTTCTTTTGCCATGG	0.483000													97	58					0	0	0.014410	0	0
ACACB	32	broad.mit.edu	37	12	109577847	109577847	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:109577847C>T	ENST00000338432.7	+	2	756	c.637C>T	c.(637-639)Cgc>Tgc	p.R213C	ACACB_ENST00000377848.3_Missense_Mutation_p.R213C|ACACB_ENST00000377854.5_Missense_Mutation_p.R213C			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	213					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGCTGAGACCCGCGTCCCCAC	0.587000													42	86					0	0	0.011902	0	0
DOCK1	1793	broad.mit.edu	37	10	128925932	128925932	+	Splice_Site	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:128925932G>T	ENST00000280333.6	+	27	2797		c.e27-1			NM_001380.3	NP_001371.1	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1						apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding	p.?(1)		NS(2)|breast(1)|central_nervous_system(7)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(10)|lung(15)|ovary(4)|prostate(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	72		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TCCTTCCCCAGGGGCCAACCC	0.473000													26	80					2.48779e-11	4.76752e-11	0.005443	1	0
KRT37	8688	broad.mit.edu	37	17	39580632	39580632	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:39580632G>T	ENST00000225550.3	-	1	143	c.144C>A	c.(142-144)aaC>aaA	p.N48K	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	48	Head.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				CGTGTGCCACGTTGGCCAAGA	0.617000													31	83					1.39806e-14	2.84469e-14	0.008361	1	0
KMT2D	8085	broad.mit.edu	37	12	49445287	49445287	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:49445287G>A	ENST00000301067.7	-	10	2178	c.2179C>T	c.(2179-2181)Cca>Tca	p.P727S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TCAGGTAGTGGCAACAGGGGT	0.692000													59	113					0	0	0.014410	0	0
KCTD2	23510	broad.mit.edu	37	17	73055632	73055632	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:73055632C>T	ENST00000322444.6	+	4	574	c.568C>T	c.(568-570)Ctg>Ttg	p.L190L	KCTD2_ENST00000581589.1_5'UTR	NM_015353.1	NP_056168.1	Q14681	KCTD2_HUMAN	potassium channel tetramerization domain containing 2	190						voltage-gated potassium channel complex	voltage-gated potassium channel activity			kidney(1)|lung(2)	3	all_lung(278;0.226)					GTACAGAGTCCTGCAGTGTCA	0.562000													16	63					0	0	0.006122	0	0
PIGO	84720	broad.mit.edu	37	9	35095491	35095491	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:35095491G>A	ENST00000378617.3	-	2	466	c.72C>T	c.(70-72)ttC>ttT	p.F24F	PIGO_ENST00000298004.5_Silent_p.F24F|PIGO_ENST00000361778.2_Silent_p.F24F|PIGO_ENST00000341666.3_Silent_p.F24F|PIGO_ENST00000492770.1_5'UTR	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	24					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			AGCCACTGGTGAAGAGGGCAA	0.582000													7	8					0	0	0.003080	0	0
MYT1L	23040	broad.mit.edu	37	2	1914022	1914022	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:1914022G>T	ENST00000399161.2	-	13	2554	c.1807C>A	c.(1807-1809)Cgc>Agc	p.R603S	MYT1L_ENST00000428368.2_Missense_Mutation_p.R601S	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	603					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CTGAGCACGCGGTCCGAGGCC	0.642000													32	55					2.85442e-18	6.11495e-18	0.010818	1	0
NLRP5	126206	broad.mit.edu	37	19	56572869	56572869	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:56572869A>G	ENST00000390649.3	+	15	3578	c.3578A>G	c.(3577-3579)gAt>gGt	p.D1193G		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1193						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TTTGATGAAGATGACCGGTAC	0.478000													36	147					0	0	0.004289	0	0
MAGEA12	4111	broad.mit.edu	37	X	151899994	151899994	+	Nonsense_Mutation	SNP	G	G	T	rs147399924	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:151899994G>T	ENST00000393900.3	-	3	1160	c.807C>A	c.(805-807)taC>taA	p.Y269*	MAGEA12_ENST00000393869.3_Nonsense_Mutation_p.Y269*|CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000357916.4_Nonsense_Mutation_p.Y269*	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	269	MAGE.									breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					ACAGGAACTCGTAGCATGCAG	0.542000													25	341					9.57634e-11	1.81537e-10	0.003330	1	0
ANKRD30BL	554226	broad.mit.edu	37	2	132914697	132914697	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:132914697G>T	ENST00000409867.1	-	3	605	c.356C>A	c.(355-357)gCt>gAt	p.A119D	ANKRD30BL_ENST00000470729.1_5'UTR					ankyrin repeat domain 30B-like											endometrium(1)|kidney(3)	4						ATTTGCACAAGCCTCCCTCTG	0.353000													4	12					1.23904e-05	2.1339e-05	0.000602	1	0
CCSER1	401145	broad.mit.edu	37	4	91549341	91549341	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:91549341A>T	ENST00000509176.1	+	6	2178	c.1890A>T	c.(1888-1890)gcA>gcT	p.A630A	CCSER1_ENST00000432775.2_Silent_p.A630A|CCSER1_ENST00000333691.8_Silent_p.A630A	NM_001145065.1	NP_001138537.1			coiled-coil serine-rich protein 1																		ACTGCACGGCAGTCAAGACGT	0.448000													33	51					0	0	0.013726	0	0
SORT1	6272	broad.mit.edu	37	1	109867652	109867652	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:109867652T>C	ENST00000256637.6	-	14	1761	c.1703A>G	c.(1702-1704)tAt>tGt	p.Y568C	SORT1_ENST00000538502.1_Missense_Mutation_p.Y431C	NM_002959.5	NP_002950.3	Q99523	SORT_HUMAN	sortilin 1	568					endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		GCCAGTGAAATAGATGGGGTC	0.488000													37	26					0	0	0.004878	0	0
ENTPD7	57089	broad.mit.edu	37	10	101439629	101439629	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:101439629A>T	ENST00000370489.4	+	5	723	c.545A>T	c.(544-546)gAg>gTg	p.E182V		NM_020354.3	NP_065087.1	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase 7	182						cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		CTTCTCCCTGAGAGGTGAGAT	0.537000													55	100					0	0	0.014410	0	0
ABCA13	154664	broad.mit.edu	37	7	48390325	48390325	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:48390325C>A	ENST00000435803.1	+	30	10314	c.10290C>A	c.(10288-10290)tgC>tgA	p.C3430*		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	3430					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TCTCTTCCTGCGTGGCACTGA	0.522000													79	98					8.41775e-28	1.98043e-27	0.014410	1	0
FAM193A	8603	broad.mit.edu	37	4	2661397	2661397	+	Splice_Site	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:2661397G>T	ENST00000324666.5	+	7	980	c.629_splice	c.e7+1	p.R210_splice	FAM193A_ENST00000505311.1_Splice_Site_p.R210_splice|FAM193A_ENST00000502458.1_Splice_Site_p.R234_splice|FAM193A_ENST00000382839.3_Splice_Site_p.R210_splice|FAM193A_ENST00000545951.1_Splice_Site_p.R210_splice	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	210										NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						TACAGGAGAAGGTAAGGCTGG	0.552000													22	142					1.55795e-14	3.14574e-14	0.012319	1	0
ZFHX4	79776	broad.mit.edu	37	8	77775684	77775684	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:77775684C>A	ENST00000521891.2	+	11	10182	c.9734C>A	c.(9733-9735)gCa>gAa	p.A3245E	ZFHX4_ENST00000455469.2_Missense_Mutation_p.A3200E|ZFHX4_ENST00000518282.1_Missense_Mutation_p.A3219E|ZFHX4_ENST00000050961.6_Missense_Mutation_p.A3196E	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3196						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CAGTTGCAGGCATTACAGAAT	0.438000										HNSCC(33;0.089)			119	215					2.06061e-42	5.5124e-42	0.014410	1	0
SLC39A11	201266	broad.mit.edu	37	17	71027788	71027788	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:71027788C>A	ENST00000542342.2	-	4	301	c.213G>T	c.(211-213)ggG>ggT	p.G71G	SLC39A11_ENST00000579732.1_Silent_p.G71G|SLC39A11_ENST00000255559.3_Silent_p.G71G	NM_001159770.1	NP_001153242.1	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11	71					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			endometrium(1)|large_intestine(4)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	16						CACCGAAGCCCCCAGAGGACG	0.532000													50	52					1.61863e-15	3.34516e-15	0.014410	1	0
RHOA	387	broad.mit.edu	37	3	49412905	49412905	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:49412905C>A	ENST00000418115.1	-	2	502	c.118G>T	c.(118-120)Gag>Tag	p.E40*	RHOA_ENST00000454011.2_Nonsense_Mutation_p.E40*|RHOA_ENST00000422781.1_Nonsense_Mutation_p.E40*	NM_001664.2	NP_001655.1	P61586	RHOA_HUMAN	ras homolog family member A	40					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding	p.E40Q(1)		cervix(1)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	ACATAGTTCTCAAACACTGTG	0.438000													118	91					3.41453e-61	9.6745e-61	0.014410	1	0
FLG	2312	broad.mit.edu	37	1	152280380	152280380	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:152280380C>T	ENST00000368799.1	-	3	7017	c.6982G>A	c.(6982-6984)Gag>Aag	p.E2328K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2328	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCGTGTCTCTCTCCTGCACTT	0.552000									Ichthyosis				660	848					0	0	0.014410	0	0
RETSAT	54884	broad.mit.edu	37	2	85578057	85578057	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:85578057G>A	ENST00000295802.4	-	3	555	c.443C>T	c.(442-444)cCc>cTc	p.P148L	RETSAT_ENST00000263854.6_Missense_Mutation_p.P148L|RETSAT_ENST00000457495.2_Missense_Mutation_p.P87L	NM_017750.3	NP_060220.3	Q6NUM9	RETST_HUMAN	retinol saturase (all-trans-retinol 13,14-reductase)	148					retinol metabolic process	endoplasmic reticulum membrane|nuclear outer membrane	all-trans-retinol 13,14-reductase activity|electron carrier activity			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	30					Vitamin A(DB00162)	AGAGGACAGGGGAGCCCAGTC	0.532000													48	59					0	0	0.013114	0	0
HTR1E	3354	broad.mit.edu	37	6	87725963	87725963	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:87725963G>T	ENST00000305344.4	+	2	1614	c.911G>T	c.(910-912)tGg>tTg	p.W304L	HTR1E_ENST00000369584.1_Missense_Mutation_p.W304L	NM_000865.2	NP_000856.1	P28566	5HT1E_HUMAN	5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled	304					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	protein binding|serotonin binding|serotonin receptor activity			breast(3)|endometrium(2)|kidney(3)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(3)	41		all_cancers(76;7.11e-06)|Acute lymphoblastic leukemia(125;1.2e-09)|Prostate(29;3.51e-09)|all_hematologic(105;7.43e-06)|all_epithelial(107;0.00819)		BRCA - Breast invasive adenocarcinoma(108;0.055)	Eletriptan(DB00216)	ATTTTATCCTGGCTGCCATTT	0.512000													81	166					6.47592e-44	1.75918e-43	0.014410	1	0
NLRC5	84166	broad.mit.edu	37	16	57111271	57111271	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:57111271G>T	ENST00000262510.6	+	41	5124	c.4899G>T	c.(4897-4899)ctG>ctT	p.L1633L	NLRC5_ENST00000539144.1_Silent_p.L1604L|NLRC5_ENST00000436936.1_3'UTR|NLRC5_ENST00000308149.7_Silent_p.L1604L	NM_032206.4	NP_115582.4	Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	1633					defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				TGCCTGGGCTGCCAGAGCTCA	0.582000													29	51					1.06801e-11	2.05417e-11	0.009535	1	0
CDC14A	8556	broad.mit.edu	37	1	100928316	100928316	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:100928316C>T	ENST00000336454.3	+	9	1072	c.717C>T	c.(715-717)gaC>gaT	p.D239D	CDC14A_ENST00000370125.2_3'UTR|CDC14A_ENST00000544534.1_Silent_p.D239D|CDC14A_ENST00000370124.3_Silent_p.D239D|CDC14A_ENST00000542213.1_Silent_p.D181D|RP5-837M10.4_ENST00000432210.1_RNA|CDC14A_ENST00000361544.6_Silent_p.D239D	NM_003672.3	NP_003663.2	Q9UNH5	CC14A_HUMAN	cell division cycle 14A	239	B.				cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		GCTTCACAGACGCTGGCTTCG	0.473000													19	46					0	0	0.007413	0	0
OBSL1	23363	broad.mit.edu	37	2	220431754	220431754	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:220431754C>A	ENST00000404537.1	-	5	1988	c.1932G>T	c.(1930-1932)caG>caT	p.Q644H	OBSL1_ENST00000373873.4_Missense_Mutation_p.Q644H|OBSL1_ENST00000603926.1_Missense_Mutation_p.Q644H|OBSL1_ENST00000373876.1_Missense_Mutation_p.Q644H|OBSL1_ENST00000265318.4_Missense_Mutation_p.Q644H|OBSL1_ENST00000289656.3_Missense_Mutation_p.Q231H	NM_015311.2	NP_056126.1	O75147	OBSL1_HUMAN	obscurin-like 1	644					cardiac myofibril assembly	intercalated disc|M band|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity						Renal(207;0.0376)		Epithelial(149;2.02e-07)|all cancers(144;1.68e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00834)		ACCAGGTACCCTGGATGATGG	0.602000													26	37					7.33532e-06	1.27162e-05	0.003954	1	0
SNAP91	9892	broad.mit.edu	37	6	84269919	84269919	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:84269919A>T	ENST00000428679.2	-	28	3128	c.2535T>A	c.(2533-2535)gcT>gcA	p.A845A	SNAP91_ENST00000437520.1_Silent_p.A538A|SNAP91_ENST00000521743.1_Silent_p.A845A|SNAP91_ENST00000521485.1_Silent_p.A840A|SNAP91_ENST00000195649.6_Silent_p.A840A|SNAP91_ENST00000520302.1_Silent_p.A815A|SNAP91_ENST00000369694.2_Silent_p.A845A|SNAP91_ENST00000520213.1_Silent_p.A538A|SNAP91_ENST00000439399.2_Silent_p.A845A			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	845	Pro-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TGCCTGTCCCAGCAGGAGGCT	0.542000													26	57					0	0	0.005443	0	0
DCTN4	51164	broad.mit.edu	37	5	150138543	150138543	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:150138543G>A	ENST00000447998.2	-	1	128	c.13C>T	c.(13-15)Ctg>Ttg	p.L5L	DCTN4_ENST00000446090.2_Silent_p.L5L	NM_016221.3	NP_057305.1	Q9UJW0	DCTN4_HUMAN	dynactin 4 (p62)	5						centrosome|nucleus	protein N-terminus binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	10		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCGACTGCAGCAAGGACGCC	0.612000													69	50					0	0	0.014410	0	0
UCHL5	51377	broad.mit.edu	37	1	192985498	192985498	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:192985498C>A	ENST00000367455.3	-	11	1208	c.973G>T	c.(973-975)Gct>Tct	p.A325S	UCHL5_ENST00000367454.1_Missense_Mutation_p.A324S|UCHL5_ENST00000367451.4_Missense_Mutation_p.A351S	NM_015984.3	NP_057068.1	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	325	Interaction with ADRM1.				DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(1)|lung(9)|ovary(1)	19						GTTTCCTGAGCTTTCTTTGCG	0.284000													84	267					2.16659e-41	5.62459e-41	0.014410	1	0
TIGD7	91151	broad.mit.edu	37	16	3349590	3349590	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:3349590T>C	ENST00000396862.1	-	2	2853	c.1025A>G	c.(1024-1026)tAt>tGt	p.Y342C	TIGD7_ENST00000268674.2_Missense_Mutation_p.Y342C	NM_033208.3	NP_149985.2	Q6NT04	TIGD7_HUMAN	tigger transposable element derived 7	342	DDE.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(1)	12						CTTCCATCTATACAGCCGTTT	0.368000													30	95					0	0	0.007291	0	0
COL12A1	1303	broad.mit.edu	37	6	75813479	75813479	+	Silent	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:75813479C>G	ENST00000322507.8	-	55	8622	c.8313G>C	c.(8311-8313)ggG>ggC	p.G2771G	COL12A1_ENST00000483888.2_Silent_p.G2771G|COL12A1_ENST00000416123.2_Silent_p.G2695G|COL12A1_ENST00000345356.6_Silent_p.G1607G	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2771	Triple-helical region (COL2) with 1 imperfection.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						TTACAATTGCCCCACTGATAC	0.378000													9	37					0	0	0.008291	0	0
KEAP1	9817	broad.mit.edu	37	19	10602620	10602620	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:10602620G>A	ENST00000171111.5	-	3	1505	c.958C>T	c.(958-960)Cgg>Tgg	p.R320W	KEAP1_ENST00000393623.2_Missense_Mutation_p.R320W	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TTGGGCGCCCGGCAGGGCATC	0.642000													27	18					0	0	0.005443	0	0
USH2A	7399	broad.mit.edu	37	1	216497666	216497666	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:216497666C>A	ENST00000366943.2	-	7	1558	c.1172G>T	c.(1171-1173)aGt>aTt	p.S391I	USH2A_ENST00000366942.3_Missense_Mutation_p.S391I|USH2A_ENST00000307340.3_Missense_Mutation_p.S391I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	391	Laminin N-terminal.		S -> I (in USH2A; uncertain pathogenicity).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGTTGTGGACTAAAGAACTG	0.318000										HNSCC(13;0.011)			11	48					2.80697e-09	5.15427e-09	0.010729	1	0
PDE10A	10846	broad.mit.edu	37	6	165842178	165842178	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:165842178C>A	ENST00000366882.1	-	11	947	c.793G>T	c.(793-795)Gtt>Ttt	p.V265F	PDE10A_ENST00000354448.4_Missense_Mutation_p.V265F|PDE10A_ENST00000539869.2_Missense_Mutation_p.V275F			Q9Y233	PDE10_HUMAN	phosphodiesterase 10A	265					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cAMP binding|cGMP binding|metal ion binding			breast(4)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(39)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	71		Breast(66;0.000425)|Prostate(117;0.104)|Ovarian(120;0.221)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-17)|BRCA - Breast invasive adenocarcinoma(81;1.8e-06)|GBM - Glioblastoma multiforme(31;1.92e-05)	Dipyridamole(DB00975)	TCTATTGCAACTATGTTATCA	0.308000													11	23					1.58986e-06	2.77437e-06	0.008291	1	0
NR5A2	2494	broad.mit.edu	37	1	200012997	200012997	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:200012997C>A	ENST00000367362.3	+	3	544	c.298C>A	c.(298-300)Ctc>Atc	p.L100I	NR5A2_ENST00000236914.3_Missense_Mutation_p.L54I|NR5A2_ENST00000544748.1_Missense_Mutation_p.L28I	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	100					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					CCATTATGGGCTCCTCACCTG	0.398000													24	46					1.85244e-09	3.42539e-09	0.003330	1	0
RNF219	79596	broad.mit.edu	37	13	79189773	79189773	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:79189773T>C	ENST00000282003.6	-	6	2181	c.2123A>G	c.(2122-2124)aAa>aGa	p.K708R	RNF219-AS1_ENST00000560584.2_RNA|RNF219-AS1_ENST00000560209.2_RNA|RNF219-AS1_ENST00000606429.1_RNA	NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	708	Ser-rich.						zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GATTTTTCTTTTTGTTGATTG	0.403000													46	196					0	0	0.014410	0	0
TRBV5-4	28611	broad.mit.edu	37	7	142168890	142168890	+	RNA	SNP	C	C	T	rs143671051	by1000genomes	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:142168890C>T	ENST00000454561.2	-	0	155																											GGGCTTGGTCCTCCTGGGGAA	0.592000													3	40					0	0	0.000602	0	0
PRDM8	56978	broad.mit.edu	37	4	81123121	81123121	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:81123121C>T	ENST00000339711.4	+	10	1736	c.505C>T	c.(505-507)Ccc>Tcc	p.P169S	PRDM8_ENST00000504452.1_Missense_Mutation_p.P169S|PRDM8_ENST00000415738.2_Missense_Mutation_p.P169S	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						GTTTGAGTTCCCCTATGTGGC	0.572000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	136					0	0	0.014410	0	0
ABCA12	26154	broad.mit.edu	37	2	215807686	215807686	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:215807686A>T	ENST00000272895.7	-	50	7618	c.7399T>A	c.(7399-7401)Ttt>Att	p.F2467I	ABCA12_ENST00000389661.4_Missense_Mutation_p.F2149I|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2467	ABC transporter 2.				cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		ATACATTGAAACTTTCCATTC	0.393000													28	51					0	0	0.008361	0	0
SEZ6L	23544	broad.mit.edu	37	22	26736548	26736548	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:26736548C>A	ENST00000529632.2	+	10	2358	c.2162C>A	c.(2161-2163)cCt>cAt	p.P721H	SEZ6L_ENST00000343706.4_Missense_Mutation_p.P721H|SEZ6L_ENST00000248933.6_Missense_Mutation_p.P721H|SEZ6L_ENST00000360929.3_Missense_Mutation_p.P721H|SEZ6L_ENST00000402979.1_Missense_Mutation_p.P494H|SEZ6L_ENST00000403121.1_Missense_Mutation_p.P494H|SEZ6L_ENST00000404234.3_Missense_Mutation_p.P721H	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	721	CUB 3.					endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						CATTCGGACCCTGCTGGCCTC	0.488000													71	43					1.93348e-29	4.63155e-29	0.014410	1	0
GPR158	57512	broad.mit.edu	37	10	25887469	25887469	+	Nonsense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:25887469A>T	ENST00000376351.3	+	11	3273	c.2914A>T	c.(2914-2916)Aaa>Taa	p.K972*	GPR158_ENST00000490549.1_3'UTR	NM_020752.2	NP_065803.2	Q5T848	GP158_HUMAN	G protein-coupled receptor 158	972						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|cervix(1)|endometrium(9)|kidney(10)|large_intestine(20)|lung(56)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	119						AAAGCCTCAGAAATCTGGGAT	0.463000													40	150					0	0	0.008740	0	0
ZNF675	171392	broad.mit.edu	37	19	23836246	23836246	+	Missense_Mutation	SNP	T	T	C	rs147297608		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:23836246T>C	ENST00000359788.4	-	4	1657	c.1489A>G	c.(1489-1491)Aca>Gca	p.T497A	ZNF675_ENST00000601935.1_Intron|ZNF675_ENST00000600313.1_Intron|ZNF675_ENST00000596211.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	497					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				CTTTTATGTGTAGTAAGGGAT	0.363000													30	24					0	0	0.010818	0	0
NYAP2	57624	broad.mit.edu	37	2	226446863	226446863	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:226446863G>A	ENST00000272907.6	+	4	1143	c.730G>A	c.(730-732)Gtg>Atg	p.V244M	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	244																	AGAGGAGCCCGTGTACATCGA	0.592000													14	309					0	0	0.004007	0	0
ZNF831	128611	broad.mit.edu	37	20	57768439	57768439	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:57768439G>T	ENST00000371030.2	+	1	2365	c.2365G>T	c.(2365-2367)Gcc>Tcc	p.A789S		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	789						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GGAAGGAGGTGCCCGAGGTGT	0.662000													29	20					3.65163e-15	7.51722e-15	0.006320	1	0
OR2T11	127077	broad.mit.edu	37	1	248790195	248790195	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:248790195G>A	ENST00000330803.2	-	1	296	c.235C>T	c.(235-237)Ctg>Ttg	p.L79L		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATGTCTGCCAGGAGTTTTGGG	0.493000													46	34					0	0	0.013114	0	0
FAM71B	153745	broad.mit.edu	37	5	156589539	156589539	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:156589539A>G	ENST00000302938.4	-	2	1832	c.1737T>C	c.(1735-1737)ggT>ggC	p.G579G		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	579						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GCTCCTGGCCACCCTGGGCTT	0.478000													225	154					0	0	0.014410	0	0
NDST4	64579	broad.mit.edu	37	4	115769409	115769409	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:115769409C>A	ENST00000264363.2	-	9	2580	c.1902G>T	c.(1900-1902)caG>caT	p.Q634H		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	634	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CATTAAAGAACTGAACTTCCT	0.328000													49	89					5.57489e-27	1.29999e-26	0.014410	1	0
IQGAP3	128239	broad.mit.edu	37	1	156532985	156532985	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:156532985C>T	ENST00000361170.2	-	8	749	c.739G>A	c.(739-741)Gtc>Atc	p.V247I		NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	247					small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCTTGGTAGACGGCTGCCAGA	0.567000													47	290					0	0	0.013114	0	0
PCMTD2	55251	broad.mit.edu	37	20	62904813	62904813	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:62904813G>C	ENST00000308824.6	+	6	1073	c.946G>C	c.(946-948)Gag>Cag	p.E316Q	PCMTD2_ENST00000369758.3_Missense_Mutation_p.E289Q|PCMTD2_ENST00000266078.6_Missense_Mutation_p.E92Q|PCMTD2_ENST00000299468.7_Intron	NM_018257.2	NP_060727.2	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	316						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(9)|upper_aerodigestive_tract(1)	17	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGACTTGGAAGAGGAACGGAG	0.537000													90	94					0	0	0.014410	0	0
CCDC88C	440193	broad.mit.edu	37	14	91770243	91770243	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr14:91770243T>C	ENST00000389857.6	-	20	3523	c.3437A>G	c.(3436-3438)aAg>aGg	p.K1146R		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1146					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTCCGTCTCCTTGGCCGTGTG	0.652000													68	38					0	0	0.014410	0	0
EEF2K	29904	broad.mit.edu	37	16	22262545	22262545	+	Nonsense_Mutation	SNP	G	G	T	rs148576611		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:22262545G>T	ENST00000263026.5	+	6	994	c.520G>T	c.(520-522)Gag>Tag	p.E174*		NM_013302.3	NP_037434.1	O00418	EF2K_HUMAN	eukaryotic elongation factor-2 kinase	174	Alpha-type protein kinase.				insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(8)|large_intestine(2)|lung(13)|ovary(1)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(48;0.0223)		GCGCTACATCGAGCCCGTAGA	0.592000													29	145					7.26314e-15	1.4836e-14	0.007291	1	0
NLRP11	204801	broad.mit.edu	37	19	56300690	56300690	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:56300690C>A	ENST00000443188.1	-	10	3299	c.2589G>T	c.(2587-2589)agG>agT	p.R863S	NLRP11_ENST00000589093.1_Missense_Mutation_p.R863S|NLRP11_ENST00000592953.1_Missense_Mutation_p.R764S|NLRP11_ENST00000589824.2_Missense_Mutation_p.R809S|NLRP11_ENST00000360133.3_Missense_Mutation_p.R809S	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	863							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TCTCCAGGCTCCTCAGTTTTT	0.423000													96	116					1.43847e-43	3.88754e-43	0.014410	1	0
EGFLAM	133584	broad.mit.edu	37	5	38337723	38337723	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:38337723G>T	ENST00000322350.5	+	2	545	c.199G>T	c.(199-201)Ggg>Tgg	p.G67W	EGFLAM_ENST00000354891.3_Missense_Mutation_p.G67W	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	67	Fibronectin type-III 1.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TCCCATCCTTGGGTACACTGT	0.512000													9	8					0.000442599	0.000745207	0.006214	1	0
PALB2	79728	broad.mit.edu	37	16	23632700	23632700	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:23632700C>A	ENST00000261584.4	-	10	3248	c.3096G>T	c.(3094-3096)atG>atT	p.M1032I	CTD-2196E14.3_ENST00000561764.1_RNA	NM_024675.3	NP_078951.2	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	1032	Interaction with RAD51 and BRCA2.				double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(21)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(3)	55				GBM - Glioblastoma multiforme(48;0.0167)		CAATGTTGTTCATAATAGTAG	0.408000			"""F, N, Mis"""			"""Wilms tumor, medulloblastoma, AML ,breast"""		Involved in tolerance or repair of DNA crosslinks					13	73					1.5739e-10	2.95176e-10	0.004007	1	0
DUSP9	1852	broad.mit.edu	37	X	152915633	152915633	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:152915633G>C	ENST00000342782.3	+	4	1293	c.1028G>C	c.(1027-1029)aGc>aCc	p.S343T	DUSP9_ENST00000370167.4_Missense_Mutation_p.S343T			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	343	Tyrosine-protein phosphatase.				inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTTGAGCGCAGCTTGCGGCTG	0.602000													142	43					0	0	0.014410	0	0
PTPRB	5787	broad.mit.edu	37	12	70956688	70956688	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:70956688G>T	ENST00000334414.6	-	16	4148	c.4104C>A	c.(4102-4104)taC>taA	p.Y1368*	PTPRB_ENST00000538708.1_Nonsense_Mutation_p.Y1060*|PTPRB_ENST00000451516.2_Nonsense_Mutation_p.Y1060*|PTPRB_ENST00000261266.5_Nonsense_Mutation_p.Y1150*|PTPRB_ENST00000551525.1_Nonsense_Mutation_p.Y1367*|PTPRB_ENST00000550857.1_Nonsense_Mutation_p.Y1060*|PTPRB_ENST00000550358.1_Nonsense_Mutation_p.Y1280*	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1150	Fibronectin type-III 16.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TCACCATCTTGTACATTCTGC	0.453000													58	115					5.19286e-32	1.27285e-31	0.014410	1	0
PIP	5304	broad.mit.edu	37	7	142832325	142832325	+	Nonsense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:142832325C>A	ENST00000291009.3	+	2	174	c.134C>A	c.(133-135)tCa>tAa	p.S45*		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	45						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		ATTCCCAAGTCAGTACGTCCA	0.448000													13	17					6.31663e-08	1.13613e-07	0.003163	1	0
BPIFB4	149954	broad.mit.edu	37	20	31685467	31685467	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:31685467C>A	ENST00000375483.3	+	11	1443	c.1443C>A	c.(1441-1443)atC>atA	p.I481I		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	481						cytoplasm|extracellular region	lipid binding										TCATCAGGATCCAGGTGCTGA	0.597000													93	122					8.92586e-32	2.16771e-31	0.014410	1	0
ACTC1	70	broad.mit.edu	37	15	35086900	35086900	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:35086900A>G	ENST00000290378.4	-	2	765	c.110T>C	c.(109-111)gTg>gCg	p.V37A	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	37					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CGGGCGGCCCACGATGGACGG	0.687000													36	47					0	0	0.003271	0	0
PCDH17	27253	broad.mit.edu	37	13	58207981	58207981	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:58207981C>T	ENST00000377918.3	+	1	1327	c.1301C>T	c.(1300-1302)aCa>aTa	p.T434I		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	434	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GACCGCGAGACACAAGACGAG	0.627000													19	73					0	0	0.014323	0	0
SNIP1	79753	broad.mit.edu	37	1	38019710	38019710	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:38019710G>A	ENST00000296215.6	-	1	193	c.121C>T	c.(121-123)Ccc>Tcc	p.P41S	SNIP1_ENST00000468040.1_Intron	NM_024700.3	NP_078976.2	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein 1	41					production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			breast(2)|cervix(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(586;0.0393)				CGGTGGGCGGGAGGTGCGACT	0.741000													8	16					0	0	0.003080	0	0
MGAT5B	146664	broad.mit.edu	37	17	74902107	74902107	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:74902107T>C	ENST00000569840.2	+	8	1437	c.863T>C	c.(862-864)gTc>gCc	p.V288A	MGAT5B_ENST00000301618.4_Missense_Mutation_p.V288A|MGAT5B_ENST00000374998.3_3'UTR|MGAT5B_ENST00000428789.2_Missense_Mutation_p.V299A	NM_001199172.1	NP_001186101.1	Q3V5L5	MGT5B_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B	288						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAGATCCTGGTCCACATCGGC	0.692000													42	88					0	0	0.014410	0	0
SLC38A10	124565	broad.mit.edu	37	17	79225400	79225400	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:79225400G>A	ENST00000374759.3	-	14	2341	c.1958C>T	c.(1957-1959)cCc>cTc	p.P653L	SLC38A10_ENST00000288439.5_Missense_Mutation_p.P653L	NM_001037984.1	NP_001033073.1	Q9HBR0	S38AA_HUMAN	solute carrier family 38, member 10	653					amino acid transport|sodium ion transport	integral to membrane				NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.117)			CGCTGGGAGGGGAGGCTTCCC	0.672000													7	31					0	0	0.006214	0	0
FAM171A1	221061	broad.mit.edu	37	10	15256130	15256130	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:15256130C>A	ENST00000378116.4	-	8	1463	c.1457G>T	c.(1456-1458)aGg>aTg	p.R486M		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	486						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GTAACTACCCCTGTAGTCATC	0.478000													41	125					2.95478e-19	6.4081e-19	0.008740	1	0
OR13G1	441933	broad.mit.edu	37	1	247836209	247836209	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:247836209G>A	ENST00000359688.2	-	1	156	c.135C>T	c.(133-135)gcC>gcT	p.A45A	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TATAGATTTTGGCAATGATGA	0.438000													40	50					0	0	0.008740	0	0
CPXM2	119587	broad.mit.edu	37	10	125526525	125526525	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:125526525A>G	ENST00000241305.3	-	10	1597	c.1443T>C	c.(1441-1443)atT>atC	p.I481I	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	481					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CAGGGATTGCAATATAGTGAT	0.453000													57	98					0	0	0.014410	0	0
TIAM1	7074	broad.mit.edu	37	21	32526706	32526706	+	Missense_Mutation	SNP	A	A	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr21:32526706A>C	ENST00000286827.3	-	18	3501	c.3030T>G	c.(3028-3030)caT>caG	p.H1010Q	TIAM1_ENST00000541036.1_Missense_Mutation_p.H950Q	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1010					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GGTTCATCTCATGCAAACTGC	0.572000													76	62					0	0	0.014410	0	0
SLC22A5	6584	broad.mit.edu	37	5	131705782	131705782	+	Missense_Mutation	SNP	G	G	C	rs148657753		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:131705782G>C	ENST00000245407.3	+	1	339	c.118G>C	c.(118-120)Gtg>Ctg	p.V40L	SLC22A5_ENST00000435065.2_Missense_Mutation_p.V40L	NM_003060.3	NP_003051.1	O76082	S22A5_HUMAN	solute carrier family 22 (organic cation/carnitine transporter), member 5	40					positive regulation of intestinal epithelial structure maintenance|quorum sensing involved in interaction with host|sodium ion transport|sodium-dependent organic cation transport	apical plasma membrane|brush border membrane|integral to membrane	ATP binding|carnitine transporter activity|PDZ domain binding|symporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|stomach(1)	8		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		L-Carnitine(DB00583)	CCTGTCCTCCGTGTTCCTGAT	0.687000											OREG0003451	type=REGULATORY REGION|Gene=BC043424|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	25	3					0	0	0.003954	0	0
SLC5A5	6528	broad.mit.edu	37	19	18001744	18001744	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:18001744C>A	ENST00000222248.3	+	14	2048	c.1701C>A	c.(1699-1701)ctC>ctA	p.L567L		NM_000453.2	NP_000444.1	Q92911	SC5A5_HUMAN	solute carrier family 5 (sodium/iodide cotransporter), member 5	567					cellular nitrogen compound metabolic process|cellular response to cAMP|cellular response to gonadotropin stimulus|hormone biosynthetic process	integral to membrane|nucleus|plasma membrane	iodide transmembrane transporter activity|sodium:iodide symporter activity			NS(2)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						GGTGGGACCTCGCACGGCAGA	0.592000													123	61					2.34035e-62	6.66683e-62	0.014410	1	0
WDR60	55112	broad.mit.edu	37	7	158715218	158715218	+	Missense_Mutation	SNP	A	A	C	rs2730238		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:158715218A>C	ENST00000407559.3	+	16	2230	c.2072A>C	c.(2071-2073)aAa>aCa	p.K691T		NM_018051.4	NP_060521.4	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	691										NS(3)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(2)|liver(4)|lung(16)|ovary(2)	35	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		GGGCCACAGAAAGTTCTGATA	0.552000													11	38					0	0	0.008291	0	0
GPR50	9248	broad.mit.edu	37	X	150349641	150349641	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:150349641C>A	ENST00000218316.3	+	2	1655	c.1586C>A	c.(1585-1587)cCt>cAt	p.P529H		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	529	Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					ACCAGCCACCCTAAGCCCACT	0.612000													89	25					2.39224e-78	6.96525e-78	0.014410	1	0
TUBGCP4	27229	broad.mit.edu	37	15	43663583	43663583	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:43663583G>A	ENST00000564079.1	+	1	271	c.31G>A	c.(31-33)Ggg>Agg	p.G11R	TUBGCP4_ENST00000570081.1_Intron|TUBGCP4_ENST00000260383.7_Missense_Mutation_p.G11R	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	11					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		GGCTCTGAGCGGGTACCCTGG	0.652000											OREG0023087	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	27	45					0	0	0.007291	0	0
ATP8B4	79895	broad.mit.edu	37	15	50152668	50152668	+	Missense_Mutation	SNP	C	C	A	rs142334062		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:50152668C>A	ENST00000284509.6	-	28	3443	c.3302G>T	c.(3301-3303)cGc>cTc	p.R1101L	ATP8B4_ENST00000559829.1_Missense_Mutation_p.R1101L	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1101					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CTGCCACCGGCGGATCTGGAG	0.498000													30	121					3.1745e-13	6.24239e-13	0.008361	1	0
LRRC7	57554	broad.mit.edu	37	1	70518799	70518799	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:70518799G>A	ENST00000310961.5	+	23	4379	c.3961G>A	c.(3961-3963)Gat>Aat	p.D1321N	LRRC7_ENST00000035383.5_Missense_Mutation_p.D1363N|LRRC7_ENST00000415775.2_Missense_Mutation_p.D647N			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1363						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TGGGAGGCGGGATGTACCTCC	0.393000													46	12					0	0	0.011902	0	0
PTDSS1	9791	broad.mit.edu	37	8	97311923	97311923	+	Splice_Site	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:97311923T>A	ENST00000517309.1	+	6	928	c.600_splice	c.e6-1	p.L201_splice	PTDSS1_ENST00000518776.1_3'UTR|PTDSS1_ENST00000522072.1_5'UTR|PTDSS1_ENST00000455950.2_Splice_Site_p.L55_splice	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	201					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	GTTTCTCAGCTCTTCTTCATG	0.433000													57	253					0	0	0.014410	0	0
CRISPLD1	83690	broad.mit.edu	37	8	75924706	75924706	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:75924706G>T	ENST00000262207.4	+	3	765	c.297G>T	c.(295-297)tgG>tgT	p.W99C	CRISPLD1_ENST00000523524.1_5'UTR|CRISPLD1_ENST00000517786.1_5'UTR|CRISPLD1_ENST00000519798.1_3'UTR	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	99						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			CAGAATCCTGGGCTGAAAGTT	0.438000													58	92					3.30226e-22	7.37411e-22	0.014410	1	0
ARL6	84100	broad.mit.edu	37	3	97506897	97506897	+	Missense_Mutation	SNP	T	T	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:97506897T>G	ENST00000463745.1	+	6	890	c.413T>G	c.(412-414)gTg>gGg	p.V138G	ARL6_ENST00000496713.1_3'UTR|ARL6_ENST00000335979.2_Missense_Mutation_p.V138G|ARL6_ENST00000394206.1_Missense_Mutation_p.V138G	NM_001278293.1	NP_001265222.1	Q9H0F7	ARL6_HUMAN	ADP-ribosylation factor-like 6	138					cilium assembly|determination of left/right symmetry|melanosome transport|protein polymerization|protein targeting to membrane|small GTPase mediated signal transduction|visual perception|Wnt receptor signaling pathway	axonemal microtubule|cilium axoneme|cilium membrane|membrane coat|microtubule basal body	GTP binding|metal ion binding|phospholipid binding|protein binding			large_intestine(1)|lung(4)	5		Lung NSC(201;0.0193)|Prostate(884;0.174)		LUSC - Lung squamous cell carcinoma(29;0.0118)|Lung(72;0.0189)		AGAGATGCAGTGACATCTGTA	0.323000													29	42					0	0	0.006320	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010492	59010492	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:59010492G>T	ENST00000263093.2	-	8	1872	c.1763C>A	c.(1762-1764)cCa>cAa	p.P588Q	SLC27A5_ENST00000599700.1_5'UTR|SLC27A5_ENST00000601355.1_Missense_Mutation_p.P504Q|SLC27A5_ENST00000594786.1_5'UTR	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	588					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CTCCGCACCTGGCACGCACAC	0.552000													39	49					2.35958e-20	5.18125e-20	0.009718	1	0
KIF19	124602	broad.mit.edu	37	17	72348161	72348161	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:72348161G>C	ENST00000599136.1	-	1	110	c.111C>G	c.(109-111)tgC>tgG	p.C37W	KIF19_ENST00000389916.4_Silent_p.S581S																							AGATGCAGTCGCACGCGCTGC	0.711000													5	8					0	0	0.001168	0	0
KIAA1109	84162	broad.mit.edu	37	4	123094284	123094284	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:123094284A>G	ENST00000264501.4	+	4	564	c.191A>G	c.(190-192)tAc>tGc	p.Y64C	KIAA1109_ENST00000455637.1_Missense_Mutation_p.Y64C|KIAA1109_ENST00000388738.3_Missense_Mutation_p.Y64C			Q2LD37	K1109_HUMAN	KIAA1109	64					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AACAGATTATACAAGCATGGC	0.323000													68	117					0	0	0.014410	0	0
LRRC4	64101	broad.mit.edu	37	7	127670542	127670542	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:127670542G>T	ENST00000249363.3	-	2	409	c.152C>A	c.(151-153)tCg>tAg	p.S51*	SND1_ENST00000354725.3_Intron	NM_022143.4	NP_071426.1	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4	51	LRRNT.					cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(4)|pancreas(1)|skin(2)	26				Lung(243;0.124)		GTTACTGCACGAGCAGACGGA	0.647000													79	92					7.63117e-38	1.93348e-37	0.014410	1	0
RGPD4	285190	broad.mit.edu	37	2	108487939	108487939	+	Missense_Mutation	SNP	T	T	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:108487939T>G	ENST00000408999.3	+	20	3556	c.3479T>G	c.(3478-3480)tTc>tGc	p.F1160C	RGPD4_ENST00000354986.4_Missense_Mutation_p.F1160C	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1160	RanBD1 1.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						GCTGAAGAATTCAAGCAGAAA	0.438000													14	217					0	0	0.001855	0	0
CHST6	4166	broad.mit.edu	37	16	75513122	75513122	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:75513122C>A	ENST00000332272.4	-	3	784	c.605G>T	c.(604-606)cGc>cTc	p.R202L	RP11-77K12.4_ENST00000530512.3_RNA|CHST6_ENST00000390664.2_Missense_Mutation_p.R202L	NM_021615.4	NP_067628.1	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6	202			R -> S (in MCD).		keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CCGCGGGTCGCGCACCAGGTG	0.687000													46	58					8.01111e-26	1.83559e-25	0.010771	1	0
LOC101927060	101927060	broad.mit.edu	37	17	45128742	45128742	+	RNA	SNP	T	T	G	rs34655963	by1000genomes	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:45128742T>G	ENST00000575173.1	-	0	418																											TAATGATTTTTATTATACTTT	0.328000													3	79					0	0	0.004672	0	0
PSG2	5670	broad.mit.edu	37	19	43579759	43579759	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:43579759G>A	ENST00000406487.1	-	3	554	c.456C>T	c.(454-456)tcC>tcT	p.S152S		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	152	Ig-like C2-type 1.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				AGTTGCTGCTGGAGATGGAGG	0.498000													78	313					0	0	0.014410	0	0
SLC9C2	284525	broad.mit.edu	37	1	173493964	173493964	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:173493964C>A	ENST00000367714.3	-	20	2890	c.2468G>T	c.(2467-2469)tGt>tTt	p.C823F	SLC9C2_ENST00000466087.1_5'UTR	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	823					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										GCCTCTTGAACAAAGGAAGGT	0.398000													44	152					9.39024e-22	2.08804e-21	0.009718	1	0
MOGAT2	80168	broad.mit.edu	37	11	75438556	75438556	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:75438556G>T	ENST00000526712.1	+	2	874	c.101G>T	c.(100-102)gGa>gTa	p.G34V	MOGAT2_ENST00000198801.5_Missense_Mutation_p.G116V			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	116					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					CTGGCAGTCGGAGCCTTTGCC	0.617000													33	92					5.8336e-16	1.21036e-15	0.003271	1	0
CTNND2	1501	broad.mit.edu	37	5	11384809	11384809	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:11384809G>A	ENST00000304623.8	-	7	1334	c.1145C>T	c.(1144-1146)aCg>aTg	p.T382M	CTNND2_ENST00000458100.2_Intron|CTNND2_ENST00000359640.2_Missense_Mutation_p.T382M|CTNND2_ENST00000511377.1_Missense_Mutation_p.T291M|CTNND2_ENST00000503622.1_Intron|CTNND2_ENST00000495388.2_5'UTR	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	382					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						GAGGGTGGCCGTGGCATACAG	0.701000													10	19					0	0	0.010729	0	0
SEC1P	653677	broad.mit.edu	37	19	49183484	49183484	+	RNA	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:49183484G>A	ENST00000430145.2	+	0	571					NR_004401.2																						AGGGCCGCCTGGGGAACCAGA	0.682000													8	11					0	0	0.004482	0	0
RNMT	8731	broad.mit.edu	37	18	13737009	13737009	+	Splice_Site	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:13737009G>T	ENST00000383314.2	+	5	794	c.553_splice	c.e5-1	p.G185_splice	RNMT_ENST00000589866.1_Splice_Site_p.G185_splice|RNMT_ENST00000592764.1_Splice_Site_p.G185_splice|RNMT_ENST00000535051.1_5'UTR|RNMT_ENST00000543302.2_Splice_Site_p.G185_splice|RNMT_ENST00000262173.3_Splice_Site_p.G185_splice			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	185					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						TCTCTTTTAGGAGAATTTTTG	0.348000													21	42					1.96292e-10	3.65534e-10	0.010504	1	0
RASSF2	9770	broad.mit.edu	37	20	4768901	4768901	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:4768901G>T	ENST00000379400.3	-	9	848	c.653C>A	c.(652-654)gCa>gAa	p.A218E	RASSF2_ENST00000478553.1_5'UTR|RASSF2_ENST00000379376.2_Missense_Mutation_p.A218E	NM_014737.2	NP_055552.1	P50749	RASF2_HUMAN	Ras association (RalGDS/AF-6) domain family member 2	218	Ras-associating.				cell cycle|signal transduction	nucleus	protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|ovary(3)|pancreas(2)|prostate(2)|skin(2)	34						AAACTCCTCTGCTGAATTCTC	0.378000													67	71					7.33394e-39	1.88536e-38	0.014410	1	0
NR1H4	9971	broad.mit.edu	37	12	100904815	100904815	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:100904815C>A	ENST00000548884.1	+	4	880	c.339C>A	c.(337-339)cgC>cgA	p.R113R	NR1H4_ENST00000392986.3_Silent_p.R113R|NR1H4_ENST00000551379.1_Silent_p.R123R|NR1H4_ENST00000188403.7_Silent_p.R123R|NR1H4_ENST00000549996.1_Silent_p.R113R	NM_001206977.1|NM_001206979.1|NM_005123.3	NP_001193906.1|NP_001193908.1|NP_005114.1	Q96RI1	NR1H4_HUMAN	nuclear receptor subfamily 1, group H, member 4	123					bile acid metabolic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(23)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	44						AGAAGCCCCGCATGGGCGCGT	0.527000													53	122					2.48254e-18	5.34e-18	0.014410	1	0
PTPRH	5794	broad.mit.edu	37	19	55693405	55693405	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:55693405C>A	ENST00000376350.3	-	19	3199	c.3177G>T	c.(3175-3177)cgG>cgT	p.R1059R	PTPRH_ENST00000263434.5_Silent_p.R881R	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1059	Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CCATCAACGGCCGACTCTCTC	0.632000													73	100					5.88917e-42	1.55959e-41	0.014410	1	0
RTN3	10313	broad.mit.edu	37	11	63449190	63449190	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:63449190G>T	ENST00000377819.5	+	1	236	c.82G>T	c.(82-84)Ggc>Tgc	p.G28C	RTN3_ENST00000341307.2_Missense_Mutation_p.G28C|RTN3_ENST00000540798.1_Missense_Mutation_p.G28C|RTN3_ENST00000537981.1_Missense_Mutation_p.G28C|RTN3_ENST00000354497.4_Missense_Mutation_p.G28C|RTN3_ENST00000538995.1_3'UTR|RTN3_ENST00000339997.4_Missense_Mutation_p.G28C|RTN3_ENST00000356000.3_Missense_Mutation_p.G28C	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	28					apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						GCCCGGCGGCGGCGGGAGCCC	0.746000													12	13					1.15088e-07	2.05597e-07	0.004007	1	0
BNC2	54796	broad.mit.edu	37	9	16727855	16727855	+	Silent	SNP	T	T	A	rs79432515		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr9:16727855T>A	ENST00000380672.4	-	3	327	c.270A>T	c.(268-270)ccA>ccT	p.P90P	BNC2_ENST00000545497.1_Intron|BNC2_ENST00000380667.2_Intron|BNC2_ENST00000380666.2_Silent_p.P90P	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		CCATGAACCCTGGTTCAGCCG	0.423000													62	171					0	0	0.014410	0	0
AHCYL2	23382	broad.mit.edu	37	7	129043237	129043237	+	Silent	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:129043237G>C	ENST00000325006.3	+	7	990	c.936G>C	c.(934-936)ggG>ggC	p.G312G	AHCYL2_ENST00000474594.1_Silent_p.G209G|AHCYL2_ENST00000531335.2_Silent_p.G231G|AHCYL2_ENST00000446212.1_Silent_p.G210G|AHCYL2_ENST00000446544.2_Silent_p.G311G|AHCYL2_ENST00000490911.1_Silent_p.G209G	NM_001130720.2|NM_015328.3	NP_001124192.1|NP_056143.1	Q96HN2	SAHH3_HUMAN	adenosylhomocysteinase-like 2	312					one-carbon metabolic process		adenosylhomocysteinase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	22						ATGATGGAGGGGATCTTACCC	0.408000													93	118					0	0	0.014410	0	0
USH2A	7399	broad.mit.edu	37	1	216166400	216166400	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:216166400G>T	ENST00000366943.2	-	35	7153	c.6767C>A	c.(6766-6768)tCc>tAc	p.S2256Y	USH2A_ENST00000307340.3_Missense_Mutation_p.S2256Y			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2256	Fibronectin type-III 9.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GACATTAAAGGAGTCAGGTGA	0.473000										HNSCC(13;0.011)	OREG0014251	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	319	364					6.11876e-135	1.83215e-134	0.014410	1	0
ABI3	51225	broad.mit.edu	37	17	47299962	47299962	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:47299962T>A	ENST00000225941.1	+	8	1484	c.986T>A	c.(985-987)tTc>tAc	p.F329Y	ABI3_ENST00000419580.2_Missense_Mutation_p.F323Y	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	329	SH3.				cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			GAGCTCTCCTTCTCTGAGGGC	0.577000										HNSCC(55;0.14)			23	65					0	0	0.014323	0	0
PKHD1	5314	broad.mit.edu	37	6	51483892	51483892	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:51483892T>C	ENST00000371117.3	-	67	12487	c.12212A>G	c.(12211-12213)cAg>cGg	p.Q4071R	RP3-335N17.2_ENST00000454361.1_RNA|RP3-335N17.2_ENST00000589278.1_RNA	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	4071					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CAGTTGCTCCTGAATAGTTTC	0.517000													3	132					0	0	0.009096	0	0
NKX3-2	579	broad.mit.edu	37	4	13543927	13543927	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:13543927A>T	ENST00000382438.5	-	2	1327	c.692T>A	c.(691-693)cTg>cAg	p.L231Q		NM_001189.3	NP_001180.1	P78367	NKX32_HUMAN	NK3 homeobox 2	231					negative regulation of chondrocyte differentiation|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|large_intestine(1)|lung(4)|prostate(1)	7						GGGCCCGGACAGGTAGCGCTG	0.672000													7	14					0	0	0.001984	0	0
ZBTB10	65986	broad.mit.edu	37	8	81399761	81399761	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:81399761C>A	ENST00000430430.1	+	2	1495	c.716C>A	c.(715-717)cCc>cAc	p.P239H	ZBTB10_ENST00000426744.2_Missense_Mutation_p.P239H|ZBTB10_ENST00000379091.4_Intron|ZBTB10_ENST00000455036.3_Missense_Mutation_p.P239H	NM_001277145.1	NP_001264074.1	Q96DT7	ZBT10_HUMAN	zinc finger and BTB domain containing 10	239					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(4)	20	all_cancers(3;1.68e-09)|all_epithelial(4;5.13e-11)|Lung NSC(7;1.75e-07)|all_lung(9;7.38e-07)|Breast(3;2.96e-06)		BRCA - Breast invasive adenocarcinoma(6;0.000434)|Epithelial(68;0.00486)|all cancers(69;0.0296)			CTCGCGCGGCCCAAGTCTCTA	0.617000													8	8					0.00307968	0.00511984	0.003080	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75924705	75924705	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:75924705G>T	ENST00000262207.4	+	3	764	c.296G>T	c.(295-297)tGg>tTg	p.W99L	CRISPLD1_ENST00000523524.1_5'UTR|CRISPLD1_ENST00000517786.1_5'UTR|CRISPLD1_ENST00000519798.1_3'UTR	NM_031461.5	NP_113649.1	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain containing 1	99						extracellular region				biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GCAGAATCCTGGGCTGAAAGT	0.443000													58	96					5.86059e-21	1.29227e-20	0.014410	1	0
LRRC66	339977	broad.mit.edu	37	4	52861367	52861367	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:52861367C>A	ENST00000343457.3	-	4	1827	c.1821G>T	c.(1819-1821)ggG>ggT	p.G607G		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	607						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GTTCAGTGCCCCCTCTTTCCT	0.463000													33	174					9.65021e-13	1.89058e-12	0.010818	1	0
PTPRH	5794	broad.mit.edu	37	19	55693406	55693406	+	Missense_Mutation	SNP	C	C	A	rs145661468	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:55693406C>A	ENST00000376350.3	-	19	3198	c.3176G>T	c.(3175-3177)cGg>cTg	p.R1059L	PTPRH_ENST00000263434.5_Missense_Mutation_p.R881L	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	1059	Tyrosine-protein phosphatase.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CATCAACGGCCGACTCTCTCT	0.632000													73	100					5.88917e-42	1.55959e-41	0.014410	1	0
N4BP2	55728	broad.mit.edu	37	4	40122701	40122701	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:40122701A>G	ENST00000261435.6	+	9	3386	c.2970A>G	c.(2968-2970)gtA>gtG	p.V990V		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	990						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						CTGGAGTAGTAGAACCACAAA	0.448000													26	111					0	0	0.006320	0	0
PCDHB14	56122	broad.mit.edu	37	5	140603356	140603356	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:140603356C>A	ENST00000239449.4	+	1	279	c.279C>A	c.(277-279)gaC>gaA	p.D93E	PCDHB14_ENST00000515856.2_Intron	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		93	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGACCGAGACGAGCTGTGTG	0.448000													147	119					9.53643e-70	2.74628e-69	0.014410	1	0
ZNF678	339500	broad.mit.edu	37	1	227838768	227838768	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:227838768G>T	ENST00000343776.4	+	3	421	c.76G>T	c.(76-78)Gtt>Ttt	p.V26F	ZNF678_ENST00000498759.1_Intron|ZNF678_ENST00000397097.3_Intron			F5GXA7	F5GXA7_HUMAN	zinc finger protein 678	81					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|pancreas(1)|prostate(1)	24		Prostate(94;0.0885)				ttataaactggtttatacagg	0.383000													133	288					2.44662e-51	6.75062e-51	0.014410	1	0
AASS	10157	broad.mit.edu	37	7	121758465	121758465	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:121758465C>A	ENST00000393376.1	-	5	678	c.583G>T	c.(583-585)Gtg>Ttg	p.V195L	AASS_ENST00000473553.1_Intron|AASS_ENST00000417368.2_Missense_Mutation_p.V195L			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	195	Lysine-ketoglutarate reductase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	ACAGCTTGCACAGCCTGACTG	0.408000													61	70					7.82978e-24	1.75587e-23	0.014410	1	0
CSMD3	114788	broad.mit.edu	37	8	113668416	113668416	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:113668416G>C	ENST00000297405.5	-	18	3215	c.2971C>G	c.(2971-2973)Cgt>Ggt	p.R991G	CSMD3_ENST00000352409.3_Missense_Mutation_p.R991G|CSMD3_ENST00000455883.2_Missense_Mutation_p.R887G|CSMD3_ENST00000343508.3_Missense_Mutation_p.R951G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	991	CUB 5.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTATTGGAACGACTGTTGTCT	0.328000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			37	105					0	0	0.006230	0	0
ARAP2	116984	broad.mit.edu	37	4	36148964	36148964	+	Nonsense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:36148964G>A	ENST00000303965.4	-	19	3706	c.3217C>T	c.(3217-3219)Caa>Taa	p.Q1073*		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	1073	PH 4.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TCCCCATTTTGAACCATTGTG	0.353000													211	120					0	0	0.014410	0	0
PTCH2	8643	broad.mit.edu	37	1	45294203	45294203	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:45294203G>A	ENST00000447098.2	-	12	1576	c.1565C>T	c.(1564-1566)cCt>cTt	p.P522L	PTCH2_ENST00000372192.3_Missense_Mutation_p.P522L	NM_001166292.1	NP_001159764.1	Q9Y6C5	PTC2_HUMAN	patched 2	522	SSD.				protein complex assembly|spermatogenesis	integral to plasma membrane	hedgehog receptor activity			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(19)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	50	Acute lymphoblastic leukemia(166;0.155)					TCGCAGCGCAGGGATGGGAAC	0.632000									Basal Cell Nevus syndrome				26	14					0	0	0.004656	0	0
TARBP2	6895	broad.mit.edu	37	12	53899526	53899526	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:53899526C>A	ENST00000266987.2	+	8	1318	c.835C>A	c.(835-837)Ctc>Atc	p.L279I	TARBP2_ENST00000456234.2_Missense_Mutation_p.L258I|TARBP2_ENST00000394357.2_Missense_Mutation_p.L258I|TARBP2_ENST00000552857.1_Missense_Mutation_p.P145H	NM_134323.1	NP_599150.1	Q15633	TRBP2_HUMAN	TAR (HIV-1) RNA binding protein 2	279	Sufficient for interaction with DICER1.				miRNA loading onto RISC involved in gene silencing by miRNA|negative regulation of defense response to virus by host|negative regulation of protein kinase activity|positive regulation of viral genome replication|pre-miRNA processing|production of siRNA involved in RNA interference|regulation of transcription from RNA polymerase II promoter|regulation of translation|regulation of viral transcription|targeting of mRNA for destruction involved in RNA interference	cytosol|nucleus|perinuclear region of cytoplasm|RNA-induced silencing complex	double-stranded RNA binding|protein homodimerization activity|siRNA binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)	10						GATCCTGTCCCTCCGCAGTTG	0.617000													8	297					0.00307968	0.00511984	0.003080	1	0
DPEP2	64174	broad.mit.edu	37	16	68024723	68024723	+	Splice_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:68024723C>A	ENST00000412757.2	-	8	1575		c.e8+1		DPEP2_ENST00000572888.1_Splice_Site|DPEP2_ENST00000393847.1_Splice_Site			Q9H4A9	DPEP2_HUMAN	dipeptidase 2						hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|proteolysis	anchored to membrane|plasma membrane	dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metalloexopeptidase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(10)|skin(2)|upper_aerodigestive_tract(1)	17		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0489)|all cancers(182;0.239)		CAGTTTCTCACCAGAAGCTGC	0.572000													171	188					9.33601e-71	2.70334e-70	0.014410	1	0
SLC6A15	55117	broad.mit.edu	37	12	85279240	85279240	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:85279240G>T	ENST00000450363.3	-	4	1006	c.548C>A	c.(547-549)cCt>cAt	p.P183H	SLC6A15_ENST00000266682.5_Missense_Mutation_p.P183H|SLC6A15_ENST00000552192.1_Missense_Mutation_p.P76H|SLC6A15_ENST00000551388.1_Intron	NM_018057.6	NP_060527.2	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	183					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						TTTCACCAAAGGACACTGATC	0.373000													56	90					6.3091e-27	1.46471e-26	0.014410	1	0
STAB2	55576	broad.mit.edu	37	12	104133198	104133198	+	Silent	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:104133198T>C	ENST00000388887.2	+	54	5910	c.5706T>C	c.(5704-5706)tgT>tgC	p.C1902C		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1902					angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AGGGGGAGTGTGGGAGCTGTG	0.413000													16	114					0	0	0.004007	0	0
PDE9A	5152	broad.mit.edu	37	21	44192569	44192569	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr21:44192569C>T	ENST00000291539.6	+	19	1767	c.1707C>T	c.(1705-1707)agC>agT	p.S569S	PDE9A_ENST00000398225.3_Silent_p.S528S|PDE9A_ENST00000398234.3_Silent_p.S468S|PDE9A_ENST00000398236.3_Silent_p.S483S|PDE9A_ENST00000539837.1_Silent_p.S441S|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000398227.3_Silent_p.S409S|PDE9A_ENST00000398224.3_Silent_p.S442S|PDE9A_ENST00000328862.6_Silent_p.S543S|PDE9A_ENST00000349112.3_Silent_p.S441S|PDE9A_ENST00000335440.6_Silent_p.S467S|PDE9A_ENST00000380328.2_Silent_p.S516S|PDE9A_ENST00000398232.3_Silent_p.S502S|PDE9A_ENST00000398229.3_Silent_p.S435S|PDE9A_ENST00000335512.4_Silent_p.S509S	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	569					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						AGACTGACAGCTTGACGTCTG	0.532000													10	5					0	0	0.013537	0	0
PNLIPRP3	119548	broad.mit.edu	37	10	118202577	118202577	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:118202577C>A	ENST00000369230.3	+	3	361	c.215C>A	c.(214-216)gCg>gAg	p.A72E		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	72					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		GAGATCAGTGCGGTTAATTCT	0.363000													10	16					0.000442599	0.000745207	0.006214	1	0
CCNE2	9134	broad.mit.edu	37	8	95897326	95897326	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:95897326T>A	ENST00000520509.1	-	9	1052	c.800A>T	c.(799-801)tAt>tTt	p.Y267F	CCNE2_ENST00000308108.4_Missense_Mutation_p.Y267F|CCNE2_ENST00000396133.3_Missense_Mutation_p.Y267F			O96020	CCNE2_HUMAN	cyclin E2	267					cell cycle checkpoint|cell division|G1/S transition of mitotic cell cycle|regulation of cyclin-dependent protein kinase activity	cytosol|nucleoplasm	protein kinase binding			cervix(1)|endometrium(2)|large_intestine(3)|lung(4)|prostate(1)	11	Breast(36;8.75e-07)					TTCCTGAGAATACTGAGGTAG	0.323000													22	74					0	0	0.012319	0	0
CPS1	1373	broad.mit.edu	37	2	211456679	211456679	+	Missense_Mutation	SNP	G	G	A	rs149930500		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:211456679G>A	ENST00000233072.5	+	10	1268	c.1072G>A	c.(1072-1074)Gat>Aat	p.D358N	CPS1_ENST00000430249.2_Missense_Mutation_p.D364N	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	358	Glutamine amidotransferase type-1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		GAATGTCAACGATCAAACAAA	0.378000													41	56					0	0	0.008740	0	0
BIRC7	79444	broad.mit.edu	37	20	61870819	61870819	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:61870819G>T	ENST00000217169.3	+	6	973	c.759G>T	c.(757-759)aaG>aaT	p.K253N	BIRC7_ENST00000342412.6_Missense_Mutation_p.K235N|BIRC7_ENST00000395306.1_Missense_Mutation_p.K148N	NM_139317.1	NP_647478.1	Q96CA5	BIRC7_HUMAN	baculoviral IAP repeat containing 7	253					activation of JUN kinase activity|anti-apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytoplasm|nucleus	enzyme binding|zinc ion binding			endometrium(1)|kidney(1)|lung(9)|ovary(1)	12	all_cancers(38;2.72e-09)					GGACGTGCAAGGTGTGCCTGG	0.692000													19	126					3.32936e-07	5.92761e-07	0.006122	1	0
SUCLG1	8802	broad.mit.edu	37	2	84668224	84668224	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:84668224C>A	ENST00000393868.2	-	5	746	c.536G>T	c.(535-537)gGa>gTa	p.G179V		NM_003849.3	NP_003840.2	P53597	SUCA_HUMAN	succinate-CoA ligase, alpha subunit	179					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity			kidney(4)|large_intestine(4)|lung(2)	10					Succinic acid(DB00139)	TTTACATTCTCCAGGCTGAAA	0.348000													23	69					4.7796e-09	8.71575e-09	0.004656	1	0
SCN3A	6328	broad.mit.edu	37	2	165987787	165987787	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:165987787C>A	ENST00000360093.3	-	16	3023	c.2532G>T	c.(2530-2532)gtG>gtT	p.V844V	SCN3A_ENST00000409101.3_Silent_p.V795V|SCN3A_ENST00000283254.7_Silent_p.V844V	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	844						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ACAATCCCTCCACATTTGACA	0.368000													58	165					1.12612e-26	2.60291e-26	0.014410	1	0
CDH22	64405	broad.mit.edu	37	20	44839121	44839121	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:44839121C>A	ENST00000372262.3	-	6	1511	c.1111G>T	c.(1111-1113)Gac>Tac	p.D371Y	CDH22_ENST00000537909.1_Missense_Mutation_p.D371Y|CDH22_ENST00000474438.1_5'UTR	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	371	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GTGCCCAGGTCGGCGAAGCGG	0.711000													14	32					7.93312e-07	1.40766e-06	0.002450	1	0
DSPP	1834	broad.mit.edu	37	4	88535365	88535365	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:88535365C>G	ENST00000399271.1	+	5	1671	c.1551C>G	c.(1549-1551)agC>agG	p.S517R	DSPP_ENST00000282478.7_Missense_Mutation_p.S517R|RP11-742B18.1_ENST00000506480.1_RNA	NM_014208.3	NP_055023.2	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein	517	Asp/Ser-rich.				biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			breast(2)|central_nervous_system(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|skin(3)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	47		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		ACAGTGATAGCACATCAGACA	0.403000													16	41					0	0	0.004007	0	0
BAIAP3	8938	broad.mit.edu	37	16	1395019	1395019	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:1395019C>T	ENST00000324385.5	+	21	2122	c.1964C>T	c.(1963-1965)aCc>aTc	p.T655I	BAIAP3_ENST00000397489.1_Missense_Mutation_p.T637I|BAIAP3_ENST00000426824.3_Missense_Mutation_p.T620I|BAIAP3_ENST00000562208.1_Missense_Mutation_p.T597I|BAIAP3_ENST00000397488.2_Missense_Mutation_p.T637I|BAIAP3_ENST00000421665.2_Missense_Mutation_p.T584I|BAIAP3_ENST00000568887.1_Missense_Mutation_p.T592I	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	655					G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				CCCAAGATGACCCTGGAGGTG	0.657000													41	54					0	0	0.008740	0	0
CSMD3	114788	broad.mit.edu	37	8	113293408	113293408	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:113293408C>G	ENST00000297405.5	-	59	9747	c.9503G>C	c.(9502-9504)tGt>tCt	p.C3168S	CSMD3_ENST00000352409.3_Missense_Mutation_p.C3098S|CSMD3_ENST00000455883.2_Missense_Mutation_p.C2999S|CSMD3_ENST00000343508.3_Missense_Mutation_p.C3128S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3168	Sushi 23.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CTTACTTGTACAGTTAGGTAA	0.318000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			25	65					0	0	0.003954	0	0
LRRC30	339291	broad.mit.edu	37	18	7231504	7231504	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:7231504T>A	ENST00000383467.2	+	1	382	c.368T>A	c.(367-369)tTt>tAt	p.F123Y		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	123										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						AAGGTCCTGTTTGTCAACATG	0.597000													24	54					0	0	0.014323	0	0
SUMF1	285362	broad.mit.edu	37	3	4459759	4459759	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:4459759C>A	ENST00000272902.5	-	5	695	c.660G>T	c.(658-660)tgG>tgT	p.W220C	SUMF1_ENST00000534863.1_Missense_Mutation_p.W220C|SUMF1_ENST00000458465.2_Intron|SUMF1_ENST00000405420.2_Missense_Mutation_p.W220C|SUMF1_ENST00000383843.5_Missense_Mutation_p.W195C	NM_182760.3	NP_877437.2	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1	220						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(3)	13		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		GCTTCCCTGCCCAAGTGCAGT	0.502000													108	69					1.09905e-38	2.81164e-38	0.014410	1	0
PWP2	5822	broad.mit.edu	37	21	45544482	45544482	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr21:45544482C>T	ENST00000291576.7	+	15	1966	c.1839C>T	c.(1837-1839)taC>taT	p.Y613Y		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	613						cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CCCTGTGCTACTCTGCAGACG	0.562000													21	52					0	0	0.003330	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													5	83					0	0	0.000602	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913138	77913138	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:77913138A>G	ENST00000321110.1	-	2	1075	c.780T>C	c.(778-780)agT>agC	p.S260S		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	260							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						CTCTCATGTAACTATACAGCT	0.507000													5	16					0	0	0.000602	0	0
FNIP2	57600	broad.mit.edu	37	4	159790038	159790038	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:159790038G>C	ENST00000264433.6	+	13	2325	c.2250G>C	c.(2248-2250)gaG>gaC	p.E750D	FNIP2_ENST00000379346.3_Missense_Mutation_p.E773D	NM_020840.1	NP_065891.1	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	750	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|prostate(1)	9	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CCTCCTTGGAGGCCAGTGAGG	0.517000													38	81					0	0	0.003755	0	0
CRISP2	7180	broad.mit.edu	37	6	49666177	49666177	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:49666177A>T	ENST00000339139.4	-	7	551	c.315T>A	c.(313-315)acT>acA	p.T105T		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	105						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAGACCAGGAAGTAGGGTCAC	0.413000													23	104					0	0	0.003330	0	0
NCKAP5	344148	broad.mit.edu	37	2	133540303	133540303	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:133540303G>C	ENST00000409261.1	-	14	4454	c.4081C>G	c.(4081-4083)Cag>Gag	p.Q1361E	NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.Q1361E	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1361							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CTCCCATGCTGACTGCTGAAG	0.617000													34	75					0	0	0.012213	0	0
CAMKK2	10645	broad.mit.edu	37	12	121701685	121701685	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:121701685C>A	ENST00000324774.5	-	6	1511	c.683G>T	c.(682-684)gGc>gTc	p.G228V	CAMKK2_ENST00000337174.3_Missense_Mutation_p.G228V|CAMKK2_ENST00000392473.2_Missense_Mutation_p.G228V|CAMKK2_ENST00000538733.1_Missense_Mutation_p.G228V|CAMKK2_ENST00000446440.2_Missense_Mutation_p.G228V|CAMKK2_ENST00000392474.2_Missense_Mutation_p.G228V|CAMKK2_ENST00000412367.2_Missense_Mutation_p.G228V|CAMKK2_ENST00000347034.2_Missense_Mutation_p.G228V|CAMKK2_ENST00000404169.3_Missense_Mutation_p.G228V|CAMKK2_ENST00000535524.1_Intron|CAMKK2_ENST00000402834.4_Missense_Mutation_p.G228V	NM_006549.3	NP_006540.3	Q96RR4	KKCC2_HUMAN	calcium/calmodulin-dependent protein kinase kinase 2, beta	228	Protein kinase.				calcium-mediated signaling|MAPKKK cascade|positive regulation of transcription, DNA-dependent|protein autophosphorylation|regulation of protein kinase activity	cytoplasm	ATP binding|calcium ion binding|calmodulin binding|calmodulin-dependent protein kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(2)|lung(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	17	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CTCAATGGGGCCCCTGGGCTG	0.607000													34	49					1.22384e-17	2.60065e-17	0.013726	1	0
AHNAK	79026	broad.mit.edu	37	11	62292534	62292534	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:62292534C>T	ENST00000378024.4	-	5	9629	c.9355G>A	c.(9355-9357)Gac>Aac	p.D3119N	AHNAK_ENST00000530124.1_Intron|AHNAK_ENST00000257247.7_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	3119					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				ACTTTCATGTCACCTTCCACT	0.478000													47	564					0	0	0.014410	0	0
TRIML1	339976	broad.mit.edu	37	4	189060808	189060808	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:189060808G>T	ENST00000332517.3	+	1	236	c.96G>T	c.(94-96)ggG>ggT	p.G32G		NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	32					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		CCGAGTGTGGGCACAGCTTTT	0.517000													68	192					7.1157e-29	1.69682e-28	0.014410	1	0
PTPRT	11122	broad.mit.edu	37	20	40730911	40730911	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:40730911C>A	ENST00000373198.3	-	27	3868	c.3633G>T	c.(3631-3633)gtG>gtT	p.V1211V	PTPRT_ENST00000373184.1_Silent_p.V1199V|PTPRT_ENST00000373193.3_Silent_p.V1192V|PTPRT_ENST00000373201.1_Silent_p.V1179V|PTPRT_ENST00000373190.1_Silent_p.V1188V|PTPRT_ENST00000356100.2_Silent_p.V1198V|PTPRT_ENST00000373187.1_Silent_p.V1189V	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1189	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTCGGGCCGCACACGGGGTG	0.562000													18	80					1.67942e-08	3.0519e-08	0.006122	1	0
OSBPL1A	114876	broad.mit.edu	37	18	21747356	21747356	+	Silent	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:21747356T>C	ENST00000319481.3	-	25	2678	c.2472A>G	c.(2470-2472)gtA>gtG	p.V824V	OSBPL1A_ENST00000357041.4_Silent_p.V442V|OSBPL1A_ENST00000399443.3_Silent_p.V311V	NM_080597.3	NP_542164.2	Q9BXW6	OSBL1_HUMAN	oxysterol binding protein-like 1A	824					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	36	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					GGATAATGAATACACTTTCAG	0.463000													47	97					0	0	0.014410	0	0
SPDEF	25803	broad.mit.edu	37	6	34506078	34506078	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:34506078G>A	ENST00000374037.3	-	6	1395	c.981C>T	c.(979-981)ctC>ctT	p.L327L	SPDEF_ENST00000544425.1_Silent_p.L311L	NM_012391.2	NP_036523.1	O95238	SPDEF_HUMAN	SAM pointed domain containing ETS transcription factor	327					negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)	15						ACTGGTAGACGAGGCGCTGGG	0.632000													37	141					0	0	0.009718	0	0
INO80	54617	broad.mit.edu	37	15	41361779	41361779	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:41361779G>C	ENST00000361937.3	-	14	2195	c.1771C>G	c.(1771-1773)Cct>Gct	p.P591A	INO80_ENST00000401393.3_Missense_Mutation_p.P591A			Q9ULG1	INO80_HUMAN	INO80 complex subunit	591	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.|Helicase ATP-binding.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						TTAAATTTAGGAACAAATCTA	0.348000													25	31					0	0	0.004656	0	0
CPSF1	29894	broad.mit.edu	37	8	145622562	145622562	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:145622562G>T	ENST00000349769.3	-	23	2546	c.2452C>A	c.(2452-2454)Ctt>Att	p.L818I		NM_013291.2	NP_037423.2	Q10570	CPSF1_HUMAN	cleavage and polyadenylation specific factor 1, 160kDa	818					mRNA cleavage|mRNA export from nucleus|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage and polyadenylation specificity factor complex	mRNA 3'-UTR binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.88e-41)|Epithelial(56;1.67e-40)|all cancers(56;1.2e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0323)|Colorectal(110;0.055)			CTGTCCACAAGGACCCGCTGC	0.662000													5	6					1.6384e-10	3.06183e-10	0.001984	1	0
KCNK18	338567	broad.mit.edu	37	10	118969418	118969418	+	Nonsense_Mutation	SNP	G	G	T	rs3026042		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:118969418G>T	ENST00000334549.1	+	3	763	c.763G>T	c.(763-765)Gaa>Taa	p.E255*		NM_181840.1	NP_862823.1	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	255			E -> K (in dbSNP:rs3026042).			integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	41		Colorectal(252;0.19)		all cancers(201;0.0211)		CTCGTGTCCCGAACTGGTGTT	0.532000													68	109					2.36135e-34	5.84241e-34	0.014410	1	0
ATP8B4	79895	broad.mit.edu	37	15	50152670	50152670	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:50152670G>A	ENST00000284509.6	-	28	3441	c.3300C>T	c.(3298-3300)atC>atT	p.I1100I	ATP8B4_ENST00000559829.1_Silent_p.I1100I	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1100					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GCCACCGGCGGATCTGGAGAG	0.498000													30	119					0	0	0.006320	0	0
COL12A1	1303	broad.mit.edu	37	6	75825638	75825638	+	Splice_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:75825638C>A	ENST00000322507.8	-	49	7868	c.7558_splice	c.e49-1	p.G2520_splice	COL12A1_ENST00000483888.2_Splice_Site_p.G2520_splice|COL12A1_ENST00000416123.2_Splice_Site_p.G2520_splice|COL12A1_ENST00000345356.6_Splice_Site_p.G1356_splice	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	2520	Nonhelical region (NC3).|TSP N-terminal.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						CATTTTAAAACCTTTACATCA	0.338000													29	56					5.77227e-19	1.24672e-18	0.008361	1	0
MDFI	4188	broad.mit.edu	37	6	41621193	41621193	+	Silent	SNP	C	C	A	rs141575722		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:41621193C>A	ENST00000373050.4	+	4	625	c.438C>A	c.(436-438)ggC>ggA	p.G146G				Q99750	MDFI_HUMAN	MyoD family inhibitor	207					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			GTGGCTCTGGCGAGTGTGCCG	0.657000													43	132					3.54561e-26	8.15954e-26	0.009718	1	0
PTDSS1	9791	broad.mit.edu	37	8	97311924	97311924	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:97311924C>A	ENST00000517309.1	+	6	929	c.603C>A	c.(601-603)ctC>ctA	p.L201L	PTDSS1_ENST00000518776.1_3'UTR|PTDSS1_ENST00000522072.1_5'UTR|PTDSS1_ENST00000455950.2_Silent_p.L55L	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	201					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TTTCTCAGCTCTTCTTCATGC	0.438000													59	250					8.81991e-31	2.12242e-30	0.014410	1	0
MTPAP	55149	broad.mit.edu	37	10	30615475	30615475	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:30615475C>G	ENST00000358107.4	-	6	1259	c.1260G>C	c.(1258-1260)gaG>gaC	p.E420D	MTPAP_ENST00000488290.1_5'UTR|MTPAP_ENST00000263063.3_Missense_Mutation_p.E290D			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	290					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						GGTCAAGGCACTCTCCTAACA	0.443000													125	169					0	0	0.014410	0	0
PTPRT	11122	broad.mit.edu	37	20	40743842	40743842	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:40743842C>A	ENST00000373198.3	-	23	3397	c.3162G>T	c.(3160-3162)caG>caT	p.Q1054H	PTPRT_ENST00000373184.1_Missense_Mutation_p.Q1042H|PTPRT_ENST00000373193.3_Missense_Mutation_p.Q1035H|PTPRT_ENST00000373201.1_Missense_Mutation_p.Q1022H|PTPRT_ENST00000373190.1_Missense_Mutation_p.Q1031H|PTPRT_ENST00000356100.2_Missense_Mutation_p.Q1041H|PTPRT_ENST00000373187.1_Missense_Mutation_p.Q1032H	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	1032	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				AGCTTACCTTCTGGACTGTGA	0.527000													29	94					8.4185e-14	1.68051e-13	0.012213	1	0
PYCRL	65263	broad.mit.edu	37	8	144687961	144687961	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:144687961A>T	ENST00000220966.6	-	6	799	c.770T>A	c.(769-771)cTc>cAc	p.L257H	PYCRL_ENST00000377579.3_Missense_Mutation_p.L108H|PYCRL_ENST00000495276.1_5'UTR	NM_023078.3	NP_075566.2	Q53H96	P5CR3_HUMAN	pyrroline-5-carboxylate reductase-like	245					proline biosynthetic process		pyrroline-5-carboxylate reductase activity			central_nervous_system(1)|endometrium(1)|lung(2)|ovary(1)	5	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.17e-38)|Epithelial(56;7.17e-37)|all cancers(56;2.46e-32)|Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CAGGGCGTGGAGTCCATAGAT	0.682000													19	104					0	0	0.010504	0	0
NOS2	4843	broad.mit.edu	37	17	26114788	26114788	+	Missense_Mutation	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:26114788C>G	ENST00000313735.6	-	5	616	c.383G>C	c.(382-384)gGa>gCa	p.G128A		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	128					arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	GTCCCTGGGTCCTCTGGTCAA	0.498000													138	150					0	0	0.014410	0	0
TRPC4	7223	broad.mit.edu	37	13	38266181	38266181	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr13:38266181G>T	ENST00000379705.3	-	4	2046	c.1189C>A	c.(1189-1191)Cca>Aca	p.P397T	TRPC4_ENST00000447043.1_Missense_Mutation_p.P397T|TRPC4_ENST00000426868.2_Missense_Mutation_p.P397T|TRPC4_ENST00000379679.1_Missense_Mutation_p.P224T|TRPC4_ENST00000355779.2_Missense_Mutation_p.P397T|TRPC4_ENST00000379673.2_Missense_Mutation_p.P397T|TRPC4_ENST00000379681.3_Missense_Mutation_p.P397T|TRPC4_ENST00000358477.2_Missense_Mutation_p.P397T|TRPC4_ENST00000338947.5_Missense_Mutation_p.P224T			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	397					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GTTGGTGGTGGACCTTGCCTG	0.438000													91	48					6.00224e-42	1.57372e-41	0.014410	1	0
CDH22	64405	broad.mit.edu	37	20	44869744	44869744	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:44869744C>A	ENST00000372262.3	-	2	808	c.408G>T	c.(406-408)cgG>cgT	p.R136R	CDH22_ENST00000537909.1_Silent_p.R136R	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	136	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				GAGCCTGGGCCCGCAGCGTGT	0.622000													24	93					7.07758e-08	1.26867e-07	0.004656	1	0
TRIM17	51127	broad.mit.edu	37	1	228602468	228602468	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:228602468G>T	ENST00000366697.2	-	1	1262	c.306C>A	c.(304-306)caC>caA	p.H102Q	TRIM17_ENST00000456946.2_Missense_Mutation_p.H102Q|TRIM17_ENST00000366698.2_Missense_Mutation_p.H102Q|TRIM17_ENST00000295033.3_Missense_Mutation_p.H102Q			Q9Y577	TRI17_HUMAN	tripartite motif containing 17	102					protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	10		Prostate(94;0.0724)				GGGGCTCGTGGTGCTCCTGGC	0.662000													76	105					8.2577e-42	2.15436e-41	0.014410	1	0
IGDCC4	57722	broad.mit.edu	37	15	65677380	65677380	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:65677380G>T	ENST00000352385.2	-	19	3463	c.3254C>A	c.(3253-3255)cCc>cAc	p.P1085H	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1085						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						AGCCGGCCGGGGGCCTGCCTG	0.672000											OREG0023195	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	57					2.5808e-16	5.41865e-16	0.006122	1	0
KDM7A	80853	broad.mit.edu	37	7	139827360	139827360	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:139827360T>C	ENST00000397560.2	-	5	680	c.583A>G	c.(583-585)Att>Gtt	p.I195V	JHDM1D_ENST00000006967.5_Missense_Mutation_p.I195V	NM_030647.1	NP_085150.1	Q6ZMT4	KDM7_HUMAN		195					midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|stomach(1)	22	Melanoma(164;0.0142)					GCCACATCAATGACATCTATC	0.353000													67	210					0	0	0.014410	0	0
AGO3	192669	broad.mit.edu	37	1	36469988	36469988	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:36469988G>T	ENST00000373191.4	+	6	1054	c.705G>T	c.(703-705)atG>atT	p.M235I	AGO3_ENST00000246314.6_Start_Codon_SNP_p.M1I|RP4-665N4.8_ENST00000466576.2_RNA	NM_024852.3	NP_079128.2			argonaute RISC catalytic component 3																		TTCAGTTCATGTGTGAAGTTC	0.328000													47	29					1.00776e-21	2.23146e-21	0.014410	1	0
ZNF646	9726	broad.mit.edu	37	16	31087950	31087950	+	Missense_Mutation	SNP	G	G	T	rs143373931	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:31087950G>T	ENST00000394979.2	+	1	728	c.305G>T	c.(304-306)cGc>cTc	p.R102L	ZNF646_ENST00000300850.5_Missense_Mutation_p.R102L			O15015	ZN646_HUMAN	zinc finger protein 646	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(1)|lung(21)|ovary(1)|prostate(4)|skin(3)	49						CCTGAGGGCCGCCGCAGGCAC	0.612000													24	65					6.21321e-17	1.30975e-16	0.002780	1	0
AHNAK2	113146	broad.mit.edu	37	14	105409967	105409967	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr14:105409967G>A	ENST00000333244.5	-	7	11940	c.11821C>T	c.(11821-11823)Cca>Tca	p.P3941S	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3941						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGGCTCCTGGGGCCTCGACG	0.602000													224	138					0	0	0.014410	0	0
HTRA4	203100	broad.mit.edu	37	8	38845496	38845496	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:38845496G>A	ENST00000302495.4	+	9	1410	c.1310G>A	c.(1309-1311)gGg>gAg	p.G437E		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	437	PDZ.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			AACATAAATGGGAAACCTATT	0.383000													31	61					0	0	0.010818	0	0
NES	10763	broad.mit.edu	37	1	156639506	156639506	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:156639506T>A	ENST00000368223.3	-	4	4606	c.4474A>T	c.(4474-4476)Agt>Tgt	p.S1492C		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1492	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GGCTCAGCACTGTCCTGGGAC	0.592000													38	89					0	0	0.006999	0	0
PIP	5304	broad.mit.edu	37	7	142832326	142832326	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:142832326A>G	ENST00000291009.3	+	2	175	c.135A>G	c.(133-135)tcA>tcG	p.S45S		NM_002652.2	NP_002643.1	P12273	PIP_HUMAN	prolactin-induced protein	45						extracellular region	actin binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	18	Melanoma(164;0.059)	Ovarian(593;2.82e-05)|Breast(660;0.012)		BRCA - Breast invasive adenocarcinoma(188;0.0026)|LUSC - Lung squamous cell carcinoma(290;0.0733)|Lung(243;0.08)		TTCCCAAGTCAGTACGTCCAA	0.443000													14	17					0	0	0.004007	0	0
DDX42	11325	broad.mit.edu	37	17	61885106	61885106	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:61885106G>T	ENST00000578681.1	+	10	1470	c.869G>T	c.(868-870)gGt>gTt	p.G290V	DDX42_ENST00000457800.2_Missense_Mutation_p.G290V|DDX42_ENST00000389924.2_Missense_Mutation_p.G290V|DDX42_ENST00000359353.5_Missense_Mutation_p.G171V|DDX42_ENST00000583590.1_Missense_Mutation_p.G290V	NM_007372.2	NP_031398.2	Q86XP3	DDX42_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 42	290	Helicase ATP-binding.				protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)	46						GCATTAAGTGGTAGAGACATG	0.398000													88	124					2.07245e-51	5.74833e-51	0.014410	1	0
ZFAT	57623	broad.mit.edu	37	8	135614646	135614646	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:135614646T>A	ENST00000520727.1	-	7	1579	c.1280A>T	c.(1279-1281)cAt>cTt	p.H427L	ZFAT_ENST00000377838.3_Missense_Mutation_p.H439L|ZFAT_ENST00000429442.2_Missense_Mutation_p.H427L|ZFAT_ENST00000523399.1_Missense_Mutation_p.H377L|ZFAT_ENST00000520356.1_Missense_Mutation_p.H427L|ZFAT_ENST00000520214.1_Missense_Mutation_p.H427L	NM_001029939.3	NP_001025110.2	Q9P243	ZFAT_HUMAN	zinc finger and AT hook domain containing	439					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(9)|large_intestine(8)|lung(16)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			GGTGGCCCCATGGCCACAGAG	0.587000													19	88					0	0	0.008871	0	0
EGFL8	80864	broad.mit.edu	37	6	32135340	32135340	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:32135340C>A	ENST00000395512.1	+	8	847	c.742C>A	c.(742-744)Cag>Aag	p.Q248K	EGFL8_ENST00000333845.6_Missense_Mutation_p.Q248K|EGFL8_ENST00000489721.1_3'UTR|PPT2-EGFL8_ENST00000422437.1_3'UTR			Q99944	EGFL8_HUMAN	EGF-like-domain, multiple 8	248						extracellular region|integral to membrane	calcium ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(4)|urinary_tract(1)	10						TGAAGAGCTGCAGCCAGAACA	0.637000													57	74					7.36392e-32	1.79666e-31	0.014410	1	0
TTLL4	9654	broad.mit.edu	37	2	219605285	219605285	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:219605285G>A	ENST00000392102.1	+	5	1979	c.1639G>A	c.(1639-1641)Gaa>Aaa	p.E547K	TTLL4_ENST00000442769.1_Missense_Mutation_p.E547K|TTLL4_ENST00000457313.1_Missense_Mutation_p.E382K|TTLL4_ENST00000258398.4_Missense_Mutation_p.E547K	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	547					protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		CTCCCCCAGCGAATCGGTGGC	0.433000													31	246					0	0	0.006230	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182639	57182639	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:57182639C>T	ENST00000504228.1	+	6	3076	c.2971C>T	c.(2971-2973)Cgc>Tgc	p.R991C	KIAA1211_ENST00000264229.6_Missense_Mutation_p.R991C|KIAA1211_ENST00000541073.1_Missense_Mutation_p.R984C			Q6ZU35	K1211_HUMAN	KIAA1211	991	Pro-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GCTGCTGTCTCGCCGAGCGGG	0.662000													7	20					0	0	0.001984	0	0
IGSF10	285313	broad.mit.edu	37	3	151164418	151164418	+	Silent	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:151164418G>A	ENST00000282466.3	-	4	3350	c.3351C>T	c.(3349-3351)ccC>ccT	p.P1117P		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1117					cell differentiation|multicellular organismal development|ossification	extracellular region		p.P1117P(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTCTACACTGGGTTTGTTCT	0.433000													127	84					0	0	0.014410	0	0
ATG9B	285973	broad.mit.edu	37	7	150720252	150720252	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:150720252C>A	ENST00000605938.1	-	4	776	c.701G>T	c.(700-702)cGa>cTa	p.R234L	ATG9B_ENST00000444312.1_5'UTR|ATG9B_ENST00000377974.2_Missense_Mutation_p.R234L|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000605952.1_Missense_Mutation_p.R234L	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	234					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		ATCCACGCATCGAAGGAGGAA	0.542000													85	200					5.92634e-42	1.56159e-41	0.014410	1	0
SALL3	27164	broad.mit.edu	37	18	76757146	76757146	+	Missense_Mutation	SNP	G	G	T	rs140437850		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:76757146G>T	ENST00000536229.3	+	3	3821	c.3112G>T	c.(3112-3114)Gtg>Ttg	p.V1038L	SALL3_ENST00000575389.2_Missense_Mutation_p.V1171L|SALL3_ENST00000537592.2_Missense_Mutation_p.V1243L			Q9BXA9	SALL3_HUMAN	spalt-like transcription factor 3	1243					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(40)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)|Melanoma(33;0.16)|Prostate(75;0.167)		OV - Ovarian serous cystadenocarcinoma(15;4.69e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0256)		CCAGCTCCCCGTGAGTCTTGG	0.607000													42	136					2.37825e-27	5.57039e-27	0.010771	1	0
SPON1	10418	broad.mit.edu	37	11	14063147	14063147	+	RNA	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:14063147G>C	ENST00000310358.7	+	0	963							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		AGGAGGACCCGGATCCAGGTG	0.473000													93	133					0	0	0.014410	0	0
NUP210	23225	broad.mit.edu	37	3	13415250	13415250	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:13415250C>A	ENST00000254508.5	-	12	1637	c.1555G>T	c.(1555-1557)Gtg>Ttg	p.V519L		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	519					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					GGGTTCTGCACATCATGTGCC	0.587000													43	25					2.43139e-17	5.14596e-17	0.014410	1	0
ELN	2006	broad.mit.edu	37	7	73456964	73456964	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:73456964G>T	ENST00000252034.7	+	6	652	c.253G>T	c.(253-255)Gtt>Ttt	p.V85F	ELN_ENST00000429192.1_Missense_Mutation_p.V85F|ELN_ENST00000380575.4_Missense_Mutation_p.V75F|ELN_ENST00000380576.5_Missense_Mutation_p.V85F|ELN_ENST00000458204.1_Missense_Mutation_p.V75F|ELN_ENST00000357036.5_Missense_Mutation_p.V85F|ELN_ENST00000380584.4_Missense_Mutation_p.V85F|ELN_ENST00000445912.1_Missense_Mutation_p.V85F|ELN_ENST00000320399.6_Missense_Mutation_p.V85F|ELN_ENST00000320492.7_Missense_Mutation_p.V73F|ELN_ENST00000358929.4_Missense_Mutation_p.V85F|ELN_ENST00000414324.1_Missense_Mutation_p.V75F|ELN_ENST00000380553.4_Intron|ELN_ENST00000380562.4_Missense_Mutation_p.V85F	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	85					blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	CTTCCCCGCAGTTACCTTTCC	0.632000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						59	88					1.69475e-38	4.31466e-38	0.014410	1	0
PNPLA3	80339	broad.mit.edu	37	22	44333104	44333104	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:44333104C>T	ENST00000216180.3	+	6	1104	c.931C>T	c.(931-933)Ccc>Tcc	p.P311S	PNPLA3_ENST00000423180.2_Missense_Mutation_p.P307S	NM_025225.2	NP_079501.2	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	311					triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|prostate(1)|skin(1)|stomach(2)	19		Ovarian(80;0.024)|all_neural(38;0.0416)				CAGCATCCTGCCCTGGGATGA	0.607000													10	38					0	0	0.006214	0	0
TOX2	84969	broad.mit.edu	37	20	42635366	42635366	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:42635366C>A	ENST00000358131.5	+	3	580	c.372C>A	c.(370-372)ctC>ctA	p.L124L	TOX2_ENST00000341197.3_Silent_p.L115L|TOX2_ENST00000423191.1_Silent_p.L73L|TOX2_ENST00000372999.1_Silent_p.L73L	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	124					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			CCATGGACCTCCCAGCCATCA	0.637000													34	24					6.90743e-12	1.33341e-11	0.003755	1	0
ACADM	34	broad.mit.edu	37	1	76205782	76205782	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:76205782G>A	ENST00000370841.4	+	7	1023	c.586G>A	c.(586-588)Gga>Aga	p.G196R	ACADM_ENST00000420607.2_Missense_Mutation_p.G200R|ACADM_ENST00000370834.5_Missense_Mutation_p.G229R|ACADM_ENST00000541113.1_Missense_Mutation_p.G160R|ACADM_ENST00000543667.1_Missense_Mutation_p.G7R	NM_000016.4|NM_001127328.1	NP_000007.1|NP_001120800.1	P11310	ACADM_HUMAN	acyl-CoA dehydrogenase, C-4 to C-12 straight chain	196					carnitine biosynthetic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|medium-chain fatty acid catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|identical protein binding|medium-chain-acyl-CoA dehydrogenase activity			breast(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|skin(1)	18						AACCAACGGAGGAAAAGCTAA	0.328000													29	29					0	0	0.013726	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													4	53					0	0	0.009096	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369339	20369339	+	RNA	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr19:20369339T>C	ENST00000593655.1	-	0	199																											AGAAACCTAATATAGATACCA	0.373000													54	122					0	0	0.014410	0	0
CYLC1	1538	broad.mit.edu	37	X	83128348	83128348	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:83128348C>A	ENST00000329312.4	+	4	669	c.632C>A	c.(631-633)aCt>aAt	p.T211N		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	211					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						AAGACAAACACTGAATTCCTA	0.308000													21	10					1.01871e-10	1.92423e-10	0.008871	1	0
NPTX2	4885	broad.mit.edu	37	7	98254413	98254413	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:98254413C>A	ENST00000265634.3	+	3	988	c.823C>A	c.(823-825)Cag>Aag	p.Q275K		NM_002523.2	NP_002514.1	P47972	NPTX2_HUMAN	neuronal pentraxin II	275	Pentaxin.				synaptic transmission	extracellular region	metal ion binding|sugar binding	p.Q275K(1)		breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	18	all_cancers(62;2.28e-09)|all_epithelial(64;4.86e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0128)|all_lung(186;0.0142)		STAD - Stomach adenocarcinoma(171;0.215)			GGTGCCAGGGCAGGCCAACGA	0.642000													24	105					3.10358e-05	5.32764e-05	0.014323	1	0
SPON1	10418	broad.mit.edu	37	11	14063148	14063148	+	RNA	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:14063148G>C	ENST00000310358.7	+	0	964							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GGAGGACCCGGATCCAGGTGT	0.478000													92	129					0	0	0.014410	0	0
SLC22A25	387601	broad.mit.edu	37	11	62932091	62932091	+	Missense_Mutation	SNP	C	C	T	rs148517822	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:62932091C>T	ENST00000306494.6	-	8	1300	c.1301G>A	c.(1300-1302)cGt>cAt	p.R434H	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000525620.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	434					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						CAAAACCACACGCAGGGTCTG	0.478000													41	47					0	0	0.007835	0	0
EDIL3	10085	broad.mit.edu	37	5	83402473	83402473	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:83402473C>A	ENST00000296591.5	-	6	1063	c.645G>T	c.(643-645)tgG>tgT	p.W215C	EDIL3_ENST00000380138.3_Missense_Mutation_p.W205C	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	215	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding	p.W215*(1)		cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TTACCTGAATCCACGGCCATC	0.398000													75	47					1.43161e-34	3.55877e-34	0.014410	1	0
MEPE	56955	broad.mit.edu	37	4	88767088	88767088	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:88767088C>A	ENST00000497649.2	+	6	1374	c.996C>A	c.(994-996)aaC>aaA	p.N332K	MEPE_ENST00000361056.3_Missense_Mutation_p.N356K|MEPE_ENST00000395102.4_Missense_Mutation_p.N387K|MEPE_ENST00000424957.3_Missense_Mutation_p.N356K|MEPE_ENST00000560249.1_Missense_Mutation_p.N243K|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000540395.1_Missense_Mutation_p.N243K			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	356					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding	p.N356K(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		GAGAAGGAAACAGAGTGGATG	0.478000													21	45					8.34094e-07	1.47506e-06	0.008871	1	0
FAM47A	158724	broad.mit.edu	37	X	34148697	34148697	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chrX:34148697G>T	ENST00000346193.3	-	1	1750	c.1699C>A	c.(1699-1701)Cat>Aat	p.H567N		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	567										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GAGAATTGATGGGACTCTGGA	0.547000													63	16					7.73544e-29	1.8363e-28	0.014410	1	0
CHEK2P2	646096	broad.mit.edu	37	15	20489494	20489494	+	RNA	SNP	A	A	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:20489494A>C	ENST00000555186.1	+	0	482					NR_038836.1																						TCTCAGAGAAAGGTATGAATA	0.428000													26	201					0	0	0.003954	0	0
CPQ	10404	broad.mit.edu	37	8	97797327	97797327	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:97797327G>A	ENST00000220763.5	+	2	412	c.202G>A	c.(202-204)Gca>Aca	p.A68T		NM_016134.2	NP_057218.1	Q9Y646	PGCP_HUMAN	carboxypeptidase Q	68					peptide metabolic process|proteolysis	cytoplasm|extracellular space	metal ion binding|metallocarboxypeptidase activity										TGAGCGATTGGCACTTCTGGT	0.438000													49	98					0	0	0.014410	0	0
GATA2	2624	broad.mit.edu	37	3	128200788	128200788	+	Splice_Site	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:128200788C>A	ENST00000341105.2	-	5	1349		c.e5-1		GATA2_ENST00000487848.1_Splice_Site|GATA2_ENST00000430265.2_Intron|GATA2_ENST00000489987.1_5'UTR	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2						blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		TGGCGGCCGACTGGGAGGGCA	0.657000			Mis		AML(CML blast transformation)								39	18					3.61848e-18	7.7204e-18	0.007835	1	0
CDH9	1007	broad.mit.edu	37	5	26881508	26881508	+	Missense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:26881508T>A	ENST00000231021.4	-	12	2279	c.2107A>T	c.(2107-2109)Act>Tct	p.T703S		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	703					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						AGAGGCACAGTCCTCCTTATC	0.418000													101	98					0	0	0.014410	0	0
GIMAP4	55303	broad.mit.edu	37	7	150269516	150269516	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:150269516G>T	ENST00000255945.2	+	3	533	c.358G>T	c.(358-360)Gtg>Ttg	p.V120L	GIMAP4_ENST00000494750.1_3'UTR|GIMAP4_ENST00000461940.1_Missense_Mutation_p.V134L	NM_018326.2	NP_060796.1	Q9NUV9	GIMA4_HUMAN	GTPase, IMAP family member 4	120							GTP binding			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(82;0.0179)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TCTGCTTCTGGTGGTTCCACT	0.493000													22	71					7.87624e-14	1.57824e-13	0.002780	1	0
MYT1	4661	broad.mit.edu	37	20	62839775	62839775	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:62839775G>T	ENST00000536311.1	+	7	1590	c.1226G>T	c.(1225-1227)gGc>gTc	p.G409V	MYT1_ENST00000360149.4_Intron|MYT1_ENST00000328439.1_Missense_Mutation_p.G409V			Q01538	MYT1_HUMAN	myelin transcription factor 1	409					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGCCAGCTGGGCCTGGGAGAG	0.657000													28	26					2.12542e-12	4.1485e-12	0.006320	1	0
COL5A2	1290	broad.mit.edu	37	2	189916924	189916924	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:189916924C>A	ENST00000374866.3	-	41	3017	c.2743G>T	c.(2743-2745)Ggc>Tgc	p.G915C		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	915					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CCAACTCTGCCCGCAGAACCA	0.363000													75	121					2.38877e-28	5.64521e-28	0.014410	1	0
SCN3A	6328	broad.mit.edu	37	2	165970341	165970341	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:165970341G>T	ENST00000360093.3	-	20	4145	c.3654C>A	c.(3652-3654)ctC>ctA	p.L1218L	SCN3A_ENST00000409101.3_Silent_p.L1169L|SCN3A_ENST00000283254.7_Silent_p.L1218L	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1218						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CACCACTACTGAGAAGGATCA	0.393000													24	159					2.21704e-12	4.31136e-12	0.002780	1	0
MGAT4C	25834	broad.mit.edu	37	12	86373526	86373526	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:86373526C>A	ENST00000604798.1	-	8	2182	c.978G>T	c.(976-978)aaG>aaT	p.K326N	MGAT4C_ENST00000548651.1_Missense_Mutation_p.K326N|MGAT4C_ENST00000393205.2_Missense_Mutation_p.K355N|MGAT4C_ENST00000332156.1_Missense_Mutation_p.K326N|MGAT4C_ENST00000552808.2_Missense_Mutation_p.K326N|MGAT4C_ENST00000552435.2_3'UTR|MGAT4C_ENST00000549405.2_Missense_Mutation_p.K326N			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	326					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						AATCATCATCCTTCAGCTTAT	0.408000													33	68					4.74835e-14	9.55108e-14	0.010818	1	0
OR51F1	256892	broad.mit.edu	37	11	4790612	4790612	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:4790612G>A	ENST00000380383.1	-	1	556	c.557C>T	c.(556-558)tCc>tTc	p.S186F	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron|OR51F1_ENST00000343430.3_Missense_Mutation_p.S179F			A6NLW9	A6NLW9_HUMAN	olfactory receptor, family 51, subfamily F, member 1	179						integral to membrane	olfactory receptor activity	p.S179F(1)		kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.87e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0045)|LUSC - Lung squamous cell carcinoma(625;0.192)		GTAACAATAGGAGTGAGAAAG	0.393000													44	68					0	0	0.011902	0	0
RUNX1T1	862	broad.mit.edu	37	8	93003958	93003958	+	Nonsense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:93003958G>T	ENST00000523629.1	-	7	1354	c.900C>A	c.(898-900)taC>taA	p.Y300*	RUNX1T1_ENST00000520724.1_Nonsense_Mutation_p.Y263*|RUNX1T1_ENST00000265814.3_Nonsense_Mutation_p.Y300*|RUNX1T1_ENST00000422361.2_Nonsense_Mutation_p.Y263*|RUNX1T1_ENST00000436581.2_Nonsense_Mutation_p.Y311*|RUNX1T1_ENST00000518844.1_Nonsense_Mutation_p.Y273*|RUNX1T1_ENST00000360348.2_Nonsense_Mutation_p.Y263*|RUNX1T1_ENST00000396218.1_Nonsense_Mutation_p.Y273*	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	300					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CATCCAAACGGTAATGCTGAG	0.557000													74	127					1.88737e-50	5.18043e-50	0.014410	1	0
OR10Q1	219960	broad.mit.edu	37	11	57996156	57996156	+	Silent	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:57996156A>G	ENST00000316770.2	-	1	234	c.192T>C	c.(190-192)taT>taC	p.Y64Y		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				ACAGGAAGAAATACATCGGGG	0.527000													26	96					0	0	0.005443	0	0
LAMA4	3910	broad.mit.edu	37	6	112455712	112455712	+	Missense_Mutation	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:112455712C>T	ENST00000230538.7	-	26	3911	c.3514G>A	c.(3514-3516)Gat>Aat	p.D1172N	LAMA4_ENST00000389463.4_Missense_Mutation_p.D1165N|LAMA4_ENST00000424408.2_Missense_Mutation_p.D1165N|LAMA4_ENST00000522006.1_Missense_Mutation_p.D1165N	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1172	Laminin G-like 2.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ATGTATATATCTGTAAAAGGT	0.373000													17	59					0	0	0.006122	0	0
TRIM11	81559	broad.mit.edu	37	1	228582544	228582544	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:228582544C>A	ENST00000493030.2	-	5	4603	c.894G>T	c.(892-894)ggG>ggT	p.G298G	TRIM11_ENST00000284551.6_Silent_p.G423G|RP11-245P10.8_ENST00000602963.1_RNA|TRIM11_ENST00000460651.1_5'UTR			Q96F44	TRI11_HUMAN	tripartite motif containing 11	423	B30.2/SPRY.				response to virus	cytoplasm|nucleus	protein binding|zinc ion binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|skin(1)	18		Prostate(94;0.0724)				ATAGCAGTGACCCATCGGTGG	0.632000													56	69					5.22555e-25	1.18192e-24	0.014410	1	0
TNS1	7145	broad.mit.edu	37	2	218713528	218713528	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:218713528C>A	ENST00000171887.4	-	17	1789	c.1337G>T	c.(1336-1338)gGc>gTc	p.G446V	TNS1_ENST00000480665.1_5'UTR|TNS1_ENST00000430930.1_Missense_Mutation_p.G446V|TNS1_ENST00000419504.1_Missense_Mutation_p.G446V	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	446						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TAAGCCAAAGCCACTCAGCAG	0.667000													70	96					4.46356e-37	1.1255e-36	0.014410	1	0
CLOCK	9575	broad.mit.edu	37	4	56336970	56336970	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:56336970G>C	ENST00000309964.4	-	7	602	c.352C>G	c.(352-354)Ctt>Gtt	p.L118V	CLOCK_ENST00000513440.1_Missense_Mutation_p.L118V|CLOCK_ENST00000381322.1_Missense_Mutation_p.L118V	NM_004898.3	NP_004889.1	O15516	CLOCK_HUMAN	clock circadian regulator	118	PAS 1.				circadian rhythm|photoperiodism|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|transcription factor complex	DNA binding|histone acetyltransferase activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(8)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(11;0.00335)|Glioma(25;0.08)|all_epithelial(27;0.0992)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0107)			AAACCATCAAGAGCCTGAAAT	0.274000													29	76					0	0	0.009535	0	0
NBEAP1	606	broad.mit.edu	37	15	20876518	20876518	+	RNA	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:20876518C>G	ENST00000556948.1	-	0	82																											CAAAGGTACTCCATGAGATAA	0.338000													28	203					0	0	0.005443	0	0
DMXL1	1657	broad.mit.edu	37	5	118469357	118469357	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:118469357G>T	ENST00000311085.8	+	12	1818	c.1738G>T	c.(1738-1740)Ggt>Tgt	p.G580C	DMXL1_ENST00000539542.1_Missense_Mutation_p.G580C	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	580										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TATTTCTTCTGGTCACAATAA	0.373000													22	61					4.35082e-09	7.96139e-09	0.010504	1	0
NEB	4703	broad.mit.edu	37	2	152470916	152470916	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:152470916C>A	ENST00000427231.2	-	77	11677	c.11475G>T	c.(11473-11475)gtG>gtT	p.V3825V	NEB_ENST00000172853.10_Silent_p.V3582V|NEB_ENST00000409198.1_Silent_p.V3582V|NEB_ENST00000604864.1_Silent_p.V3825V|NEB_ENST00000397345.3_Silent_p.V3825V|NEB_ENST00000603639.1_Silent_p.V3825V	NM_001164507.1	NP_001157979.1	P20929	NEBU_HUMAN	nebulin	3825					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TCTTGGCCAGCACCACCCCCA	0.527000													281	341					1.52656e-134	4.54518e-134	0.014410	1	0
CLU	1191	broad.mit.edu	37	8	27466544	27466544	+	Missense_Mutation	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:27466544C>A	ENST00000316403.10	-	3	562	c.157G>T	c.(157-159)Gtg>Ttg	p.V53L	CLU_ENST00000523500.1_Missense_Mutation_p.V53L|CLU_ENST00000560366.1_Missense_Mutation_p.V105L|CLU_ENST00000405140.3_Missense_Mutation_p.V53L|CLU_ENST00000546343.1_Missense_Mutation_p.V64L			P10909	CLUS_HUMAN	clusterin	53					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		ATCTGTTTCACCCCGTTGACA	0.443000													77	166					6.20995e-33	1.52927e-32	0.014410	1	0
LZTS2	84445	broad.mit.edu	37	10	102763434	102763434	+	Silent	SNP	C	C	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:102763434C>G	ENST00000370220.1	+	2	3642	c.579C>G	c.(577-579)tcC>tcG	p.S193S	LZTS2_ENST00000370223.3_Silent_p.S193S			Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	193	Required for centrosomal localization (By similarity).|Ser-rich.				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		cctcctcttcctcctcctctt	0.642000													78	365					0	0	0.014410	0	0
POLR2A	5430	broad.mit.edu	37	17	7406556	7406556	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:7406556G>C	ENST00000322644.6	+	17	3272	c.2873G>C	c.(2872-2874)cGg>cCg	p.R958P		NM_000937.4	NP_000928.1	P24928	RPB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	958					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(8)|lung(17)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	50		Prostate(122;0.173)				GAATTTGAGCGGATGCGGGAG	0.602000													30	83					0	0	0.010818	0	0
GOLGA8EP	390535	broad.mit.edu	37	15	23444033	23444033	+	RNA	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:23444033G>A	ENST00000526079.1	+	0	1677					NR_027407.1|NR_033350.1																						TCTGGACAGTGAGGGGGAGGA	0.627000													15	196					0	0	0.010504	0	0
ULK4	54986	broad.mit.edu	37	3	41996204	41996204	+	Silent	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr3:41996204A>T	ENST00000301831.4	-	2	510	c.48T>A	c.(46-48)acT>acA	p.T16T	ULK4_ENST00000420927.1_Silent_p.T16T|ULK4_ENST00000414606.1_Silent_p.T16T	NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	16	Protein kinase.						ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TATAGACAACAGTCTTGCTTC	0.418000													75	50					0	0	0.014410	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000256078.4_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000556131.1_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			17	25					1.5739e-10	2.95176e-10	0.004007	1	0
UNC5D	137970	broad.mit.edu	37	8	35616958	35616958	+	Missense_Mutation	SNP	T	T	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:35616958T>C	ENST00000287272.2	+	13	2097	c.2077T>C	c.(2077-2079)Tgg>Cgg	p.W693R	UNC5D_ENST00000416672.1_Missense_Mutation_p.W767R|UNC5D_ENST00000449677.1_Missense_Mutation_p.W338R|UNC5D_ENST00000453357.2_Missense_Mutation_p.W757R|UNC5D_ENST00000420357.1_Missense_Mutation_p.W695R|UNC5D_ENST00000404895.2_Missense_Mutation_p.W762R			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	762					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCCATTCCTCTGGAGAATTAA	0.458000													4	411					0	0	0.000602	0	0
CES5A	221223	broad.mit.edu	37	16	55903558	55903558	+	Silent	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:55903558G>T	ENST00000521992.1	-	5	748	c.603C>A	c.(601-603)gtC>gtA	p.V201V	CES5A_ENST00000290567.9_Silent_p.V172V|CES5A_ENST00000520435.1_Silent_p.V142V|CES5A_ENST00000541580.1_Intron|CES5A_ENST00000518005.1_Silent_p.V66V|CES5A_ENST00000319165.9_Silent_p.V172V	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	172						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						GGTACTGGACGACCACAACCA	0.547000													30	34					5.8336e-16	1.21036e-15	0.003271	1	0
OR2AG2	338755	broad.mit.edu	37	11	6790080	6790080	+	Missense_Mutation	SNP	A	A	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:6790080A>T	ENST00000338569.2	-	1	206	c.109T>A	c.(109-111)Ttg>Atg	p.L37M		NM_001004490.1	NP_001004490.1	A6NM03	O2AG2_HUMAN	olfactory receptor, family 2, subfamily AG, member 2	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(13)|ovary(1)|skin(5)|stomach(1)|urinary_tract(1)	28		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.15e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GTCAGTGCCAACATGTATAGG	0.537000													61	84					0	0	0.014410	0	0
CLNK	116449	broad.mit.edu	37	4	10527500	10527500	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:10527500G>T	ENST00000226951.6	-	14	935	c.696C>A	c.(694-696)aaC>aaA	p.N232K	CLNK_ENST00000442825.2_Intron	NM_052964.2	NP_443196.2	Q7Z7G1	CLNK_HUMAN	cytokine-dependent hematopoietic cell linker	232					immune response|intracellular signal transduction	intracellular	SH3/SH2 adaptor activity			NS(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(1)	17						GAGTATTTTGGTTTTCTAACA	0.418000													12	0					6.81908e-15	1.39831e-14	0.002450	1	0
INSC	387755	broad.mit.edu	37	11	15134022	15134022	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:15134022C>A	ENST00000379554.3	+	1	53	c.7C>A	c.(7-9)Cgg>Agg	p.R3R		NM_001031853.3	NP_001027024.3	Q1MX18	INSC_HUMAN	inscuteable homolog (Drosophila)	3					cell differentiation|nervous system development	cytoplasm	binding	p.R3W(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(3)|lung(24)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49						AGCCATGAGACGGCCCCCTGG	0.627000													40	48					1.02591e-13	2.03253e-13	0.010771	1	0
DSE	29940	broad.mit.edu	37	6	116757507	116757507	+	Missense_Mutation	SNP	G	G	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr6:116757507G>C	ENST00000331677.3	+	7	2320	c.1876G>C	c.(1876-1878)Gag>Cag	p.E626Q	DSE_ENST00000537543.1_Missense_Mutation_p.E645Q|DSE_ENST00000359564.2_Missense_Mutation_p.E626Q|DSE_ENST00000452085.3_Missense_Mutation_p.E626Q			Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	626					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TGGCTACAGCGAGAAAGCAAC	0.493000													24	68					0	0	0.004656	0	0
LZTS1	11178	broad.mit.edu	37	8	20110358	20110358	+	Nonsense_Mutation	SNP	T	T	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:20110358T>A	ENST00000381569.1	-	3	1441	c.1084A>T	c.(1084-1086)Aag>Tag	p.K362*	LZTS1_ENST00000265801.6_Nonsense_Mutation_p.K362*|LZTS1_ENST00000522290.1_Nonsense_Mutation_p.K362*			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	362					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GACCTGAGCTTGGTCTCCAGC	0.642000													23	63					0	0	0.014323	0	0
RP1	6101	broad.mit.edu	37	8	55537428	55537428	+	Missense_Mutation	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr8:55537428G>T	ENST00000220676.1	+	4	1134	c.986G>T	c.(985-987)gGc>gTc	p.G329V		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	329					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AATCAAGACGGCACTATGACA	0.323000													20	65					5.03518e-11	9.61428e-11	0.007413	1	0
TRBV5-4	28611	broad.mit.edu	37	7	142168862	142168862	+	RNA	SNP	A	A	G	rs140095394	by1000genomes	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:142168862A>G	ENST00000454561.2	-	0	183																											TGGGCCAGGCAGCACTGCACC	0.597000													3	48					0	0	0.000602	0	0
SSPO	23145	broad.mit.edu	37	7	149502627	149502627	+	RNA	SNP	G	G	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr7:149502627G>T	ENST00000378016.2	+	0	8440							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			ATCCTGCCCAGGAGATGCCAC	0.682000													23	53					2.52088e-20	5.51246e-20	0.002780	1	0
CUBN	8029	broad.mit.edu	37	10	16975228	16975228	+	Silent	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr10:16975228C>A	ENST00000377833.4	-	40	6047	c.5982G>T	c.(5980-5982)ccG>ccT	p.P1994P		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	1994	CUB 14.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity	p.G1995C(1)		breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CAGGCCAGCCCGGGGAGAAGA	0.507000													25	72					1.26454e-06	2.22138e-06	0.005443	1	0
RCOR3	55758	broad.mit.edu	37	1	211486235	211486235	+	Missense_Mutation	SNP	A	A	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:211486235A>G	ENST00000367005.4	+	10	1216	c.1075A>G	c.(1075-1077)Act>Gct	p.T359A	RCOR3_ENST00000452621.2_Missense_Mutation_p.T417A|RCOR3_ENST00000367006.4_Intron|RCOR3_ENST00000419091.2_Missense_Mutation_p.T417A|RCOR3_ENST00000526255.1_3'UTR	NM_018254.3	NP_060724.1	Q9P2K3	RCOR3_HUMAN	REST corepressor 3	359					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21				OV - Ovarian serous cystadenocarcinoma(81;0.00961)|all cancers(67;0.0999)|Epithelial(68;0.171)		TGATGCTTCTACTTTAGGGGA	0.443000													64	122					0	0	0.014410	0	0
KLKB1	3818	broad.mit.edu	37	4	187173004	187173004	+	Missense_Mutation	SNP	G	G	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:187173004G>A	ENST00000264690.6	+	10	1320	c.1133G>A	c.(1132-1134)gGg>gAg	p.G378E	KLKB1_ENST00000513864.1_Missense_Mutation_p.G378E	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	378					blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		TGTAACACTGGGGACAACTCT	0.418000													42	88					0	0	0.010771	0	0
IGLV2-14	28815	broad.mit.edu	37	22	23101412	23101412	+	RNA	SNP	C	C	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:23101412C>A	ENST00000390312.2	+	0	107																											CCCAGTCTGCCCTGACTCAGC	0.592000													125	86					1.20474e-87	3.52722e-87	0.014410	1	0
PHF21B	112885	broad.mit.edu	37	22	45312349	45312349	+	Silent	SNP	C	C	T			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr22:45312349C>T	ENST00000313237.5	-	4	525	c.375G>A	c.(373-375)gcG>gcA	p.A125A	PHF21B_ENST00000403565.1_5'UTR|PHF21B_ENST00000396103.3_Silent_p.A125A|PHF21B_ENST00000404079.2_Silent_p.A113A|PHF21B_ENST00000447824.3_Silent_p.A113A	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	125							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		GGCTGCCGGGCGCTGGCACAT	0.701000													23	64					0	0	0.003330	0	0
RP11-739N20.2	0	broad.mit.edu	37	1	204363979	204363980	+	RNA	INS	-	-	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr1:204363979_204363980insA	ENST00000443515.1	+	0	146																											atttgtttttcaaaaaaaaaaa	0.307													6	4	---	---	---	---					
LINC01122	400955	broad.mit.edu	37	2	58688420	58688421	+	RNA	INS	-	-	C			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:58688420_58688421insC	ENST00000452840.1	+	0	127																											AGGCCATGCGGCCCGGCAGGAA	0.490													12	35	---	---	---	---					
SPRED2	200734	broad.mit.edu	37	2	65540928	65540928	+	Frame_Shift_Del	DEL	G	G	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr2:65540928delG	ENST00000356388.4	-	6	1153	c.964delC	c.(964-966)gcfs	p.R323fs	SPRED2_ENST00000443619.2_Frame_Shift_Del_p.R320fs	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	323	SPR.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						TGGCCCCGGCGGTTCTCCTCG	0.662													94	260	---	---	---	---					
YTHDC1	91746	broad.mit.edu	37	4	69199072	69199073	+	Frame_Shift_Ins	INS	-	-	G			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr4:69199072_69199073insG	ENST00000344157.4	-	5	1261_1262	c.926_927insC	c.(925-927)catfs	p.H309fs	YTHDC1_ENST00000579690.1_Frame_Shift_Ins_p.H309fs|YTHDC1_ENST00000355665.3_Frame_Shift_Ins_p.H309fs	NM_001031732.2	NP_001026902.1	Q96MU7	YTDC1_HUMAN	YTH domain containing 1	309										NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	30						CAAAAACAATTGGAGATATGCC	0.332													75	258	---	---	---	---					
RICTOR	253260	broad.mit.edu	37	5	38959321	38959325	+	Frame_Shift_Del	DEL	GGAAA	GGAAA	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:38959321_38959325delGGAAA	ENST00000357387.3	-	22	2180_2184	c.2150_2154delTTTCC	c.(2149-2154)cfs	p.LS717fs	RICTOR_ENST00000503698.1_5'UTR|RICTOR_ENST00000296782.5_Frame_Shift_Del_p.LS717fs	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	717					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					TTAAAATTTTGGAAAGGATGACTCT	0.337													8	109	---	---	---	---					
AC008694.3	0	broad.mit.edu	37	5	157116925	157116925	+	RNA	DEL	C	C	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr5:157116925delC	ENST00000522076.1	-	0	333																											AAACCAGACTCCCCTGCTGTC	0.443													48	27	---	---	---	---					
PPFIBP2	8495	broad.mit.edu	37	11	7661015	7661020	+	In_Frame_Del	DEL	CAGGAG	CAGGAG	-	rs137855547	byFrequency	TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr11:7661015_7661020delCAGGAG	ENST00000299492.4	+	15	1677_1682	c.1289_1294delCAGGAG	c.(1288-1296)tcc>t	p.SGA430del	PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000530181.1_In_Frame_Del_p.SGA287del|PPFIBP2_ENST00000533792.1_In_Frame_Del_p.SGA272del|PPFIBP2_ENST00000528883.1_In_Frame_Del_p.SGA318del	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	430					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GGGAAGCTTTCAGGAGCCACGCCCAA	0.568													53	245	---	---	---	---					
LRRIQ1	84125	broad.mit.edu	37	12	85449548	85449549	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr12:85449548_85449549insA	ENST00000393217.2	+	8	1038_1039	c.977_978insA	c.(976-978)gaafs	p.E326fs		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	326	Glu-rich.									breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		gaaaaggaagcaaaaatacgac	0.332													17	58	---	---	---	---					
CHRNA3	1136	broad.mit.edu	37	15	78913068	78913070	+	In_Frame_Del	DEL	CAG	CAG	-	rs72025661		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:78913068_78913070delCAG	ENST00000326828.5	-	1	451_453	c.67_69delCTG	c.(67-69)del	p.L23del	CHRNA3_ENST00000348639.3_In_Frame_Del_p.L23del	NM_000743.4	NP_000734.2	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3 (neuronal)	23			Missing.		activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						gcagcagagacagcagcagcagc	0.768													4	3	---	---	---	---					
CERS3	204219	broad.mit.edu	37	15	101013174	101013174	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr15:101013174delC	ENST00000284382.4	-	10	1116	c.693delG	c.(691-693)ggfs	p.G231fs	CERS3_ENST00000394113.1_Frame_Shift_Del_p.G231fs|CERS3_ENST00000538112.2_Frame_Shift_Del_p.G231fs|CERS3_ENST00000560944.1_Intron	NM_178842.3	NP_849164.2	Q8IU89	CERS3_HUMAN	ceramide synthase 3	231	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										TCACGAGGGTCCCACTGCGAA	0.433													24	129	---	---	---	---					
RP11-483K5.3	0	broad.mit.edu	37	16	8580574	8580575	+	RNA	DEL	AG	AG	-	rs149054995		TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr16:8580574_8580575delAG	ENST00000562516.1	-	0	84																											cgagggagacagagaggagaga	0.480													4	4	---	---	---	---					
MPP3	4356	broad.mit.edu	37	17	41905182	41905182	+	Frame_Shift_Del	DEL	C	C	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr17:41905182delC	ENST00000398393.1	-	6	795	c.535delG	c.(535-537)acfs	p.D179fs	MPP3_ENST00000398389.4_Frame_Shift_Del_p.D154fs			Q13368	MPP3_HUMAN	membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)	154	PDZ.				signal transduction	cell surface|integral to plasma membrane	guanylate kinase activity			endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Breast(137;0.00394)		BRCA - Breast invasive adenocarcinoma(366;0.119)		GAGTGCTCGTCCCGCCGGATG	0.627													41	156	---	---	---	---					
ATP9B	374868	broad.mit.edu	37	18	77102279	77102289	+	Frame_Shift_Del	DEL	AACAGGCGATA	AACAGGCGATA	-			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr18:77102279_77102289delAACAGGCGATA	ENST00000426216.2	+	20	2312_2322	c.2295_2305delAACAGGCGATA	c.(2293-2307)ctaafs	p.LTGDK765fs	ATP9B_ENST00000543761.1_Frame_Shift_Del_p.LTGDK86fs|RP11-800A18.4_ENST00000592906.1_RNA|ATP9B_ENST00000307671.7_Frame_Shift_Del_p.LTGDK765fs	NM_198531.3	NP_940933.3	O43861	ATP9B_HUMAN	ATPase, class II, type 9B	765					ATP biosynthetic process	integral to membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(3)|prostate(1)|skin(2)|stomach(1)	38		Esophageal squamous(42;0.018)|Melanoma(33;0.0964)|Prostate(75;0.171)		OV - Ovarian serous cystadenocarcinoma(15;1.44e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0405)		TATGGATGCTAACAGGCGATAAACTCGAGAC	0.379													16	124	---	---	---	---					
EYA2	2139	broad.mit.edu	37	20	45808534	45808535	+	Frame_Shift_Ins	INS	-	-	A			TCGA-75-7027-01A-11D-1945-08	TCGA-75-7027-10A-01D-1946-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b9b8d0a7-d8a2-4806-a5f4-6dcb072b510d	af6b81ce-4107-4511-a892-41fa763fd576	g.chr20:45808534_45808535insA	ENST00000327619.5	+	13	1661_1662	c.1287_1288insA	c.(1285-1290)ctaggcfs	p.G430fs	EYA2_ENST00000357410.3_Intron|EYA2_ENST00000317304.6_Frame_Shift_Ins_p.G400fs	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	430					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity	p.L429L(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				CCCACTCCCTGAAGGCACTAAA	0.559													47	64	---	---	---	---					
