Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF860	344787	broad.mit.edu	37	3	32031784	32031784	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:32031784A>G	ENST00000360311.4	+	2	1762	c.1213A>G	c.(1213-1215)Aaa>Gaa	p.K405E		NM_001137674.2	NP_001131146.2	A6NHJ4	ZN860_HUMAN	zinc finger protein 860	405					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(1)	8						TGATTGTCACAAAGTCTTCAG	0.363000													5	32					0	0	0.001984	0	0
TG	7038	broad.mit.edu	37	8	133880403	133880403	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:133880403G>C	ENST00000220616.4	+	2	151	c.111G>C	c.(109-111)caG>caC	p.Q37H	TG_ENST00000377869.1_Missense_Mutation_p.Q37H	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	37	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GTGAGCTGCAGAGGGAAACGG	0.547000													13	114					0	0	0.002450	0	0
UGT1A9	54600	broad.mit.edu	37	2	234581085	234581085	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:234581085G>A	ENST00000354728.4	+	1	587	c.505G>A	c.(505-507)Gcc>Acc	p.A169T	UGT1A10_ENST00000373445.1_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A8_ENST00000373450.4_Intron	NM_021027.2	NP_066307.1														breast(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	37		Breast(86;0.000766)|all_lung(227;0.00269)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0331)|Lung NSC(271;0.0459)|Lung SC(224;0.128)		Epithelial(121;1.26e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000436)|Lung(119;0.00347)|LUSC - Lung squamous cell carcinoma(224;0.00757)		CGTGGTCTTCGCCAGGGGAAT	0.458000													32	201					0	0	0.015359	0	0
WDR70	55100	broad.mit.edu	37	5	37379592	37379592	+	Splice_Site	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:37379592G>A	ENST00000265107.4	+	2	183	c.25_splice	c.e2-1	p.V9_splice	WDR70_ENST00000504564.1_Splice_Site_p.V9_splice	NM_018034.2	NP_060504.1	Q9NW82	WDR70_HUMAN	WD repeat domain 70	9										central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_lung(31;0.000285)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTGCTCCAGTGACAGGCTCAG	0.662000													31	67					0	0	0.010818	0	0
CRP	1401	broad.mit.edu	37	1	159683534	159683534	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:159683534G>A	ENST00000255030.5	-	2	559	c.456C>T	c.(454-456)atC>atT	p.I152I	CRP_ENST00000437342.1_5'UTR|CRP_ENST00000368112.1_Intron|CRP_ENST00000368110.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368111.1_Intron|CRP_ENST00000473196.1_5'UTR	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	152	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	CCTGCCCCAAGATGATGCTTG	0.547000													121	263					0	0	0.014410	0	0
OR52R1	119695	broad.mit.edu	37	11	4825663	4825663	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:4825663T>A	ENST00000380382.1	-	1	184	c.185A>T	c.(184-186)tAt>tTt	p.Y62F	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGCAGATGATAACAATCAAA	0.403000													9	26					0	0	0.006214	0	0
OXNAD1	92106	broad.mit.edu	37	3	16336367	16336367	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:16336367G>T	ENST00000285083.5	+	6	760	c.295G>T	c.(295-297)Gat>Tat	p.D99Y	OXNAD1_ENST00000605932.1_Missense_Mutation_p.D99Y|OXNAD1_ENST00000435829.2_Missense_Mutation_p.D117Y|OXNAD1_ENST00000544043.1_Missense_Mutation_p.D117Y|OXNAD1_ENST00000606098.1_Missense_Mutation_p.D99Y	NM_138381.3	NP_612390.1	Q96HP4	OXND1_HUMAN	oxidoreductase NAD-binding domain containing 1	99	FAD-binding FR-type.						oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(5)|skin(2)	13						TTTTAGGGTTGATTTCTTTAT	0.338000													19	37					5.03518e-11	5.9265e-11	0.007413	1	0
RABEP2	79874	broad.mit.edu	37	16	28916339	28916339	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:28916339A>G	ENST00000358201.4	-	13	2223	c.1635T>C	c.(1633-1635)gcT>gcC	p.A545A	RABEP2_ENST00000357573.6_Silent_p.A509A|RABEP2_ENST00000544477.1_Silent_p.A474A	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	545					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						CCAGGGTCTCAGCCTGGCGGA	0.652000													18	17					0	0	0.007413	0	0
UPRT	139596	broad.mit.edu	37	X	74494380	74494380	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:74494380A>G	ENST00000373379.1	+	1	456	c.291A>G	c.(289-291)ctA>ctG	p.L97L	UPRT_ENST00000531704.1_3'UTR|UPRT_ENST00000373383.4_Silent_p.L97L			Q96BW1	UPP_HUMAN	uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)	97					nucleoside metabolic process	cytoplasm|nucleus				breast(1)|endometrium(7)|kidney(2)|large_intestine(4)|lung(4)	18						ACTCCTTCCTAGAGGACTGCG	0.577000													18	9					0	0	0.004990	0	0
KMT2C	58508	broad.mit.edu	37	7	151927076	151927076	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:151927076C>A	ENST00000355193.2	-	18	3126	c.2908G>T	c.(2908-2910)Gca>Tca	p.A970S	KMT2C_ENST00000262189.6_Missense_Mutation_p.A970S					lysine (K)-specific methyltransferase 2C																		CTTCCTTCTGCTCCTTGGCCA	0.353000													12	301					3.99206e-14	4.83383e-14	0.007413	1	0
ALDH16A1	126133	broad.mit.edu	37	19	49969066	49969066	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:49969066T>A	ENST00000293350.4	+	13	1803	c.1640T>A	c.(1639-1641)aTc>aAc	p.I547N	ALDH16A1_ENST00000540132.1_Missense_Mutation_p.I384N|CTD-3148I10.9_ENST00000599536.1_Intron|ALDH16A1_ENST00000433981.2_Missense_Mutation_p.I382N|ALDH16A1_ENST00000455361.2_Missense_Mutation_p.I496N	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	547							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TCCAGGCCCATCCGGGATTCG	0.647000													4	30					0	0	0.009096	0	0
NRXN1	9378	broad.mit.edu	37	2	50149334	50149334	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:50149334G>A	ENST00000404971.1	-	24	5731	c.4392C>T	c.(4390-4392)atC>atT	p.I1464I	NRXN1_ENST00000401710.1_Silent_p.I412I|NRXN1_ENST00000406316.2_Silent_p.I1394I|NRXN1_ENST00000405472.3_Silent_p.I1416I|NRXN1_ENST00000401669.2_Silent_p.I1424I|NRXN1_ENST00000342183.5_Silent_p.I359I|NRXN1_ENST00000406859.3_Silent_p.I1394I|NRXN1_ENST00000402717.3_Silent_p.I1416I	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1394					adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TGGACTCCCGGATCACTTCTG	0.532000													15	41					0	0	0.004007	0	0
ADPRHL2	54936	broad.mit.edu	37	1	36557266	36557266	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:36557266G>T	ENST00000373178.4	+	3	386	c.356G>T	c.(355-357)gGa>gTa	p.G119V		NM_017825.2	NP_060295.1	Q9NX46	ARHL2_HUMAN	ADP-ribosylhydrolase like 2	119						cytoplasm|nucleus	metal ion binding|poly(ADP-ribose) glycohydrolase activity			cervix(1)|endometrium(2)|large_intestine(1)|lung(3)|pancreas(1)	8		Myeloproliferative disorder(586;0.0393)				TATGGTGCTGGAGTAGTCACT	0.507000													26	49					5.45727e-16	6.69354e-16	0.008361	1	0
MTHFSD	64779	broad.mit.edu	37	16	86565716	86565716	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:86565716G>A	ENST00000322911.6	-	8	1100	c.1050C>T	c.(1048-1050)gaC>gaT	p.D350D	MTHFSD_ENST00000543303.2_Silent_p.D350D|MTHFSD_ENST00000546093.1_Silent_p.D188D|MTHFSD_ENST00000381214.5_Silent_p.D351D|MTHFSD_ENST00000360900.6_Silent_p.D351D	NM_001159377.1|NM_022764.2	NP_001152849.1|NP_073601.2	Q2M296	MTHSD_HUMAN	methenyltetrahydrofolate synthetase domain containing	351	RRM.				folic acid-containing compound biosynthetic process		5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|RNA binding			endometrium(1)|large_intestine(3)|lung(6)|skin(1)	11						CTGCGGCAGAGTCCGGGTAAT	0.701000													7	20					0	0	0.001984	0	0
MS4A3	932	broad.mit.edu	37	11	59837144	59837144	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:59837144G>C	ENST00000278865.3	+	6	684	c.611G>C	c.(610-612)aGa>aCa	p.R204T	MS4A3_ENST00000534744.1_Missense_Mutation_p.R158T|MS4A3_ENST00000395032.2_Missense_Mutation_p.R81T|MS4A3_ENST00000358152.2_Missense_Mutation_p.R158T	NM_006138.4	NP_006129.4	Q96HJ5	MS4A3_HUMAN	membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)	204						endomembrane system|integral to membrane|perinuclear region of cytoplasm	protein binding|receptor activity			endometrium(4)|kidney(2)|lung(9)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		all_epithelial(135;0.245)				TGTAATTCAAGAGAGGTGAGA	0.403000													97	68					0	0	0.014410	0	0
SLC29A3	55315	broad.mit.edu	37	10	73122032	73122032	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:73122032C>T	ENST00000373189.5	+	6	1147	c.1095C>T	c.(1093-1095)ctC>ctT	p.L365L	SLC29A3_ENST00000469204.1_3'UTR	NM_001174098.1|NM_018344.5	NP_001167569.1|NP_060814.4	Q9BZD2	S29A3_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 3	365					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|late endosome membrane|lysosomal membrane	nucleoside transmembrane transporter activity			endometrium(3)|kidney(2)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	15						GCCGGCAGCTCACCGCCTGGA	0.597000													32	146					0	0	0.008361	0	0
LPHN2	23266	broad.mit.edu	37	1	82417743	82417743	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:82417743G>T	ENST00000370728.1	+	11	2344	c.1699G>T	c.(1699-1701)Gag>Tag	p.E567*	LPHN2_ENST00000370730.1_Nonsense_Mutation_p.E567*|LPHN2_ENST00000271029.4_Nonsense_Mutation_p.E567*|LPHN2_ENST00000394879.1_Nonsense_Mutation_p.E567*|LPHN2_ENST00000359929.3_Nonsense_Mutation_p.E567*|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370715.1_Nonsense_Mutation_p.E567*|LPHN2_ENST00000335786.5_Nonsense_Mutation_p.E567*|LPHN2_ENST00000370721.1_Nonsense_Mutation_p.E505*|LPHN2_ENST00000370723.1_Nonsense_Mutation_p.E567*|LPHN2_ENST00000370725.1_Nonsense_Mutation_p.E567*|LPHN2_ENST00000370717.2_Nonsense_Mutation_p.E567*|LPHN2_ENST00000319517.6_Nonsense_Mutation_p.E567*|LPHN2_ENST00000370727.1_Nonsense_Mutation_p.E567*|LPHN2_ENST00000370713.1_Nonsense_Mutation_p.E567*			O95490	LPHN2_HUMAN	latrophilin 2	567					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		GAGATTGATGGAGCAGTTGGT	0.458000													15	12					1.3612e-06	1.52632e-06	0.003163	1	0
TECTA	7007	broad.mit.edu	37	11	121008503	121008503	+	Silent	SNP	C	C	T	rs142573400	byFrequency	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:121008503C>T	ENST00000392793.1	+	11	3586	c.3315C>T	c.(3313-3315)taC>taT	p.Y1105Y	TECTA_ENST00000264037.2_Silent_p.Y1105Y			O75443	TECTA_HUMAN	tectorin alpha	1105	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		TCTCAGGCTACGGCCACTACC	0.582000													5	31					0	0	0.014758	0	0
ELAC2	60528	broad.mit.edu	37	17	12905612	12905612	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:12905612C>A	ENST00000338034.4	-	14	1522	c.1283G>T	c.(1282-1284)cGt>cTt	p.R428L	ELAC2_ENST00000395962.2_Missense_Mutation_p.R409L|ELAC2_ENST00000426905.3_Missense_Mutation_p.R388L	NM_018127.6|NM_173717.1	NP_060597.4|NP_776065.1	Q9BQ52	RNZ2_HUMAN	elaC ribonuclease Z 2	428					tRNA processing	nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|skin(1)	23						CCTCCTGGGACGGAGCTGGTA	0.493000													14	30					1.3612e-06	1.52632e-06	0.003163	1	0
POU3F1	5453	broad.mit.edu	37	1	38511276	38511276	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:38511276C>T	ENST00000373012.2	-	1	1174	c.1140G>A	c.(1138-1140)aaG>aaA	p.K380K		NM_002699.3	NP_002690.3	Q03052	PO3F1_HUMAN	POU class 3 homeobox 1	380					positive regulation of transcription, DNA-dependent		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.K380N(1)		cervix(1)|lung(1)|upper_aerodigestive_tract(1)	3	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GCACCACCTCCTTCTCCAGCT	0.672000													4	12					0	0	0.009096	0	0
SPEG	10290	broad.mit.edu	37	2	220327061	220327061	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:220327061C>T	ENST00000312358.7	+	8	2790	c.2658C>T	c.(2656-2658)gtC>gtT	p.V886V	SPEG_ENST00000396686.1_Silent_p.V37V|SPEG_ENST00000396688.1_Silent_p.V37V|SPEG_ENST00000396698.1_Silent_p.V782V|SPEG_ENST00000485813.1_3'UTR|SPEG_ENST00000396689.2_Silent_p.V37V|SPEG_ENST00000396695.2_Silent_p.V94V	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	886	Ig-like 3.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCCAAGATGTCATCATGAGCA	0.602000													3	5					0	0	0.004672	0	0
PCDH15	65217	broad.mit.edu	37	10	55566757	55566757	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:55566757T>C	ENST00000373965.2	-	36	5031	c.4637A>G	c.(4636-4638)aAt>aGt	p.N1546S	PCDH15_ENST00000414778.1_Missense_Mutation_p.N1543S	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				AATATATATATTGCCGTTGAT	0.483000										HNSCC(58;0.16)			9	36					0	0	0.006214	0	0
ACSL6	23305	broad.mit.edu	37	5	131308521	131308521	+	Missense_Mutation	SNP	G	G	A	rs140341663	byFrequency	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:131308521G>A	ENST00000379264.2	-	13	1342	c.1234C>T	c.(1234-1236)Cgc>Tgc	p.R412C	ACSL6_ENST00000379255.1_Missense_Mutation_p.R312C|ACSL6_ENST00000379246.1_Missense_Mutation_p.R398C|ACSL6_ENST00000543479.1_Missense_Mutation_p.R387C|ACSL6_ENST00000379240.1_Missense_Mutation_p.R387C|ACSL6_ENST00000544770.1_Missense_Mutation_p.R296C|ACSL6_ENST00000379272.2_Missense_Mutation_p.R402C|ACSL6_ENST00000357096.1_Missense_Mutation_p.R312C|ACSL6_ENST00000431707.1_Missense_Mutation_p.R367C|ACSL6_ENST00000296869.4_Missense_Mutation_p.R412C|ACSL6_ENST00000379244.1_Missense_Mutation_p.R387C|ACSL6_ENST00000379249.3_Missense_Mutation_p.R387C	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	387					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AGGAGCCAGCGCTTTAATGGT	0.458000													23	41					0	0	0.016522	0	0
NCAM1	4684	broad.mit.edu	37	11	113075215	113075215	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:113075215T>C	ENST00000316851.7	+	2	305	c.305T>C	c.(304-306)gTg>gCg	p.V102A	NCAM1_ENST00000401611.2_Missense_Mutation_p.V111A|NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000533760.1_5'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	112	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		ACCGTCAACGTGAAGATCTTT	0.517000													28	19					0	0	0.006320	0	0
PCDHB11	56125	broad.mit.edu	37	5	140581426	140581426	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:140581426G>A	ENST00000354757.3	+	1	2079	c.2079G>A	c.(2077-2079)gcG>gcA	p.A693A	PCDHB11_ENST00000536699.1_Silent_p.A328A	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		693					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding	p.A693A(1)		NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGTGGTGGCGTTGGCCTCGG	0.692000													89	114					0	0	0.014410	0	0
PRDM1	639	broad.mit.edu	37	6	106554835	106554835	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:106554835G>C	ENST00000369096.4	+	7	2186	c.1952G>C	c.(1951-1953)cGa>cCa	p.R651P	PRDM1_ENST00000369089.3_Missense_Mutation_p.R517P|PRDM1_ENST00000369091.2_Missense_Mutation_p.R615P	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	651					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		ACCCACCTGCGACTCCATTCT	0.547000			"""D, N, Mis, F, S"""		DLBCL								10	79					0	0	0.002450	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919577	142919577	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:142919577A>T	ENST00000408947.3	+	1	448	c.406A>T	c.(406-408)Agg>Tgg	p.R136W		NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	136					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					CCTGATGAAGAGGAAAATCAT	0.423000													47	125					0	0	0.011902	0	0
ANK3	288	broad.mit.edu	37	10	61844939	61844939	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:61844939G>A	ENST00000280772.1	-	31	4012	c.3821C>T	c.(3820-3822)tCc>tTc	p.S1274F	ANK3_ENST00000355288.2_Missense_Mutation_p.S408F|ANK3_ENST00000503366.1_Missense_Mutation_p.S1275F|ANK3_ENST00000373827.2_Missense_Mutation_p.S1268F	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1274					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGTTGTAAAGGAGACACAATC	0.388000													20	4					0	0	0.012319	0	0
SORL1	6653	broad.mit.edu	37	11	121476152	121476152	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:121476152G>C	ENST00000260197.7	+	35	4949	c.4820G>C	c.(4819-4821)aGc>aCc	p.S1607T	SORL1_ENST00000534286.1_Missense_Mutation_p.S517T|SORL1_ENST00000525532.1_Missense_Mutation_p.S551T|SORL1_ENST00000532694.1_Missense_Mutation_p.S453T|SORL1_ENST00000527934.1_Missense_Mutation_p.S222T	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1607	Fibronectin type-III 1.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GAGACCCACAGCAATAAGACA	0.448000													22	151					0	0	0.014323	0	0
PRUNE2	158471	broad.mit.edu	37	9	79320553	79320553	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:79320553C>G	ENST00000428286.1	-	8	6760	c.5560G>C	c.(5560-5562)Gat>Cat	p.D1854H	PRUNE2_ENST00000376718.3_Missense_Mutation_p.D2213H			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	2213					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GGTGCCATATCTGGGCTGGCT	0.448000													24	66					0	0	0.004656	0	0
GRIA4	2893	broad.mit.edu	37	11	105774606	105774606	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:105774606C>A	ENST00000393127.2	+	8	1398	c.952C>A	c.(952-954)Cag>Aag	p.Q318K	GRIA4_ENST00000530497.1_Missense_Mutation_p.Q318K|GRIA4_ENST00000282499.5_Missense_Mutation_p.Q318K|GRIA4_ENST00000428631.2_Missense_Mutation_p.Q318K|GRIA4_ENST00000393125.2_Missense_Mutation_p.Q318K|GRIA4_ENST00000525187.1_Missense_Mutation_p.Q318K	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	318					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TCTTAGGAGGCAGAAAATTGA	0.443000													8	90					3.09899e-07	3.49558e-07	0.004482	1	0
ACIN1	22985	broad.mit.edu	37	14	23549752	23549752	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:23549752C>G	ENST00000262710.1	-	6	1293	c.966G>C	c.(964-966)gaG>gaC	p.E322D	ACIN1_ENST00000605057.1_Missense_Mutation_p.E264D|ACIN1_ENST00000555053.1_Missense_Mutation_p.E322D|ACIN1_ENST00000457657.1_Missense_Mutation_p.E282D	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	322	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TTTTGGGTCTCTCATCCATCA	0.463000													19	50					0	0	0.005443	0	0
EPAS1	2034	broad.mit.edu	37	2	46607470	46607470	+	Silent	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:46607470G>C	ENST00000263734.3	+	12	2169	c.1659G>C	c.(1657-1659)gcG>gcC	p.A553A		NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	553					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GGCTCTTGGCGGAGAACCCAC	0.597000													108	39					0	0	0.014410	0	0
TRPM3	80036	broad.mit.edu	37	9	73152282	73152282	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:73152282C>T	ENST00000377110.2	-	25	3954	c.3711G>A	c.(3709-3711)gaG>gaA	p.E1237E	TRPM3_ENST00000396280.5_Silent_p.E1086E|TRPM3_ENST00000377111.2_Silent_p.E1237E|TRPM3_ENST00000358082.3_Silent_p.E1099E|TRPM3_ENST00000396285.1_Silent_p.E1096E|TRPM3_ENST00000360823.2_Silent_p.E1099E|TRPM3_ENST00000396292.4_Silent_p.E1109E|TRPM3_ENST00000357533.2_Silent_p.E1241E|TRPM3_ENST00000423814.3_Silent_p.E1264E|TRPM3_ENST00000377105.1_Silent_p.E1096E|TRPM3_ENST00000377106.1_Silent_p.E1109E|TRPM3_ENST00000408909.2_Silent_p.E1096E	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1262						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						AGTGCTCTCTCTCGTTGACTT	0.602000													14	25					0	0	0.003163	0	0
MYPN	84665	broad.mit.edu	37	10	69959140	69959140	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:69959140C>T	ENST00000358913.5	+	17	3789	c.3301C>T	c.(3301-3303)Ccc>Tcc	p.P1101S	MYPN_ENST00000540630.1_Missense_Mutation_p.P1101S|MYPN_ENST00000354393.2_Missense_Mutation_p.P826S	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	1101	Ig-like 4.|Interaction with ACTN.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						TGGTTTACCGCCCCCGGAGCT	0.507000													10	20					0	0	0.008291	0	0
PHOX2A	401	broad.mit.edu	37	11	71952288	71952288	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:71952288C>T	ENST00000298231.5	-	2	434	c.263G>A	c.(262-264)cGc>cAc	p.R88H	PHOX2A_ENST00000544057.1_5'UTR	NM_005169.3	NP_005160.2	O14813	PHX2A_HUMAN	paired-like homeobox 2a	88					noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)	5						CCGCTGCTTGCGCTTCTCGTG	0.647000													16	32					0	0	0.006122	0	0
SNX13	23161	broad.mit.edu	37	7	17931175	17931175	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:17931175G>A	ENST00000409389.1	-	4	484	c.312C>T	c.(310-312)ctC>ctT	p.L104L	SNX13_ENST00000409604.1_Silent_p.L104L|SNX13_ENST00000428135.3_Silent_p.L104L			Q9Y5W8	SNX13_HUMAN	sorting nexin 13	104	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					TCACTTGCTGGAGAGGTTCAT	0.338000													17	41					0	0	0.006122	0	0
PENK	5179	broad.mit.edu	37	8	57354089	57354089	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:57354089C>G	ENST00000314922.3	-	2	622	c.546G>C	c.(544-546)gtG>gtC	p.V182V	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Silent_p.V182V	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	182					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			ATCTCTTGCTCACTTCTTCCT	0.517000													40	78					0	0	0.008740	0	0
PDLIM5	10611	broad.mit.edu	37	4	95444920	95444920	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:95444920G>T	ENST00000317968.4	+	3	278	c.142G>T	c.(142-144)Gat>Tat	p.D48Y	PDLIM5_ENST00000450793.1_Missense_Mutation_p.D48Y|PDLIM5_ENST00000538141.1_Missense_Mutation_p.D48Y|PDLIM5_ENST00000380180.3_Missense_Mutation_p.D48Y|PDLIM5_ENST00000437932.1_Missense_Mutation_p.D48Y|PDLIM5_ENST00000318007.5_Missense_Mutation_p.D48Y|PDLIM5_ENST00000542407.1_Intron|PDLIM5_ENST00000514743.1_Missense_Mutation_p.D48Y|PDLIM5_ENST00000508216.1_Missense_Mutation_p.D48Y	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	48	PDZ.				regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		AAGAATAGGCGATGTGGTTCT	0.378000													10	15					4.68919e-08	5.36919e-08	0.008291	1	0
TAF3	83860	broad.mit.edu	37	10	8006790	8006790	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:8006790C>T	ENST00000344293.5	+	3	1523	c.1317C>T	c.(1315-1317)tcC>tcT	p.S439S		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	439					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						CTTCCACTTCCGCGAACAATT	0.468000													25	98					0	0	0.018920	0	0
ANO4	121601	broad.mit.edu	37	12	101504206	101504206	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:101504206T>C	ENST00000392979.3	+	22	2430	c.2069T>C	c.(2068-2070)aTc>aCc	p.I690T	ANO4_ENST00000392977.3_Missense_Mutation_p.I725T|ANO4_ENST00000550015.1_Missense_Mutation_p.I245T|ANO4_ENST00000299222.9_Missense_Mutation_p.I245T	NM_178826.3	NP_849148.2	Q32M45	ANO4_HUMAN	anoctamin 4	725						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TTCACAACTATCTTTGTGGCA	0.363000										HNSCC(74;0.22)			12	45					0	0	0.002450	0	0
HPS4	89781	broad.mit.edu	37	22	26861450	26861450	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:26861450G>A	ENST00000398145.2	-	10	1390	c.774C>T	c.(772-774)ctC>ctT	p.L258L	HPS4_ENST00000398141.1_Silent_p.L271L|HPS4_ENST00000336873.5_Silent_p.L258L|HPS4_ENST00000402105.3_Silent_p.L253L	NM_022081.4	NP_071364.4	Q9NQG7	HPS4_HUMAN	Hermansky-Pudlak syndrome 4	258					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity			breast(2)|endometrium(3)|kidney(5)|large_intestine(4)|lung(12)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	32						GGAACTCGTGGAGACTAATGG	0.488000									Hermansky-Pudlak syndrome				12	52					0	0	0.013537	0	0
ALK	238	broad.mit.edu	37	2	30142880	30142880	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:30142880G>C	ENST00000389048.3	-	1	1552	c.646C>G	c.(646-648)Ctc>Gtc	p.L216V	ALK_ENST00000431873.1_Missense_Mutation_p.L216V	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	216					protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	ATCTGGAAGAGAAGGCGGGGC	0.562000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				19	12					0	0	0.010504	0	0
MYOCD	93649	broad.mit.edu	37	17	12666905	12666905	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:12666905G>C	ENST00000425538.1	+	14	3105	c.2905G>C	c.(2905-2907)Gat>Cat	p.D969H	MYOCD_ENST00000343344.4_Missense_Mutation_p.D921H|RP11-1090M7.1_ENST00000584772.1_RNA	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	921					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CGATTTCCTGGATGTCACTGA	0.512000													3	34					0	0	0.004672	0	0
OR2G6	391211	broad.mit.edu	37	1	248685664	248685664	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:248685664G>A	ENST00000343414.4	+	1	749	c.717G>A	c.(715-717)ggG>ggA	p.G239G		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	239					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGCCTTTGGGACCTGTTCGT	0.458000													22	64					0	0	0.010504	0	0
CILP	8483	broad.mit.edu	37	15	65499247	65499247	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:65499247C>A	ENST00000261883.4	-	4	463	c.297G>T	c.(295-297)tgG>tgT	p.W99C		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	99					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						CCGCAGGTGTCCAGTCAGTGG	0.632000													12	17					3.07112e-06	3.42339e-06	0.010729	1	0
KRTAP26-1	388818	broad.mit.edu	37	21	31692174	31692174	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:31692174G>A	ENST00000360542.3	-	1	433	c.180C>T	c.(178-180)tgC>tgT	p.C60C		NM_203405.1	NP_981950.1	Q6PEX3	KR261_HUMAN	keratin associated protein 26-1	60						intermediate filament				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16						TTGGTTCACCGCAGGTCTCTT	0.567000													38	53					0	0	0.007835	0	0
TMEM143	55260	broad.mit.edu	37	19	48845932	48845932	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:48845932T>C	ENST00000293261.3	-	6	1146	c.830A>G	c.(829-831)cAg>cGg	p.Q277R	TMEM143_ENST00000541566.1_Missense_Mutation_p.Q167R|TMEM143_ENST00000435956.3_Missense_Mutation_p.Q242R|TMEM143_ENST00000436660.2_Missense_Mutation_p.Q212R|TMEM143_ENST00000377431.2_Missense_Mutation_p.Q177R	NM_018273.2	NP_060743.2	Q96AN5	TM143_HUMAN	transmembrane protein 143	277						integral to membrane|mitochondrion				endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	14		all_epithelial(76;9.64e-05)|all_lung(116;0.000147)|Lung NSC(112;0.000251)|Prostate(7;0.0187)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000149)|all cancers(93;0.000198)|Epithelial(262;0.0151)|GBM - Glioblastoma multiforme(486;0.0157)		CAGGGCGCGCTGCAGGGTGGG	0.637000													3	34					0	0	0.004672	0	0
FMN2	56776	broad.mit.edu	37	1	240601508	240601508	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:240601508G>A	ENST00000319653.9	+	16	5288	c.5058G>A	c.(5056-5058)gaG>gaA	p.E1686E	FMN2_ENST00000545751.1_Silent_p.E282E	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1686	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TTCTACAAGAGAGGTAGGTAT	0.388000													9	55					0	0	0.004482	0	0
RNF141	50862	broad.mit.edu	37	11	10555597	10555597	+	Missense_Mutation	SNP	C	C	G	rs149870408		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:10555597C>G	ENST00000265981.2	-	2	251	c.109G>C	c.(109-111)Gaa>Caa	p.E37Q	RNF141_ENST00000528665.1_Missense_Mutation_p.E37Q	NM_016422.3	NP_057506.2	Q8WVD5	RN141_HUMAN	ring finger protein 141	37							zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|urinary_tract(1)	9				all cancers(16;4.63e-08)|Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.064)		CCAAGAAATTCTTCATAAGTT	0.393000													18	32					0	0	0.007413	0	0
MTA1	9112	broad.mit.edu	37	14	105911754	105911754	+	Splice_Site	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:105911754G>C	ENST00000331320.7	+	3	310		c.e3-1		MTA1_ENST00000406191.1_Splice_Site|MTA1_ENST00000405646.1_Splice_Site	NM_001203258.1|NM_004689.3	NP_001190187.1|NP_004680.2	Q13330	MTA1_HUMAN	metastasis associated 1						signal transduction	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|stomach(1)	14		all_cancers(154;0.0293)|all_epithelial(191;0.128)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00897)|Epithelial(46;0.026)	Epithelial(152;0.19)		TGCTGTTACAGACGGCCAATG	0.647000													20	50					0	0	0.014323	0	0
TRIOBP	11078	broad.mit.edu	37	22	38120013	38120013	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:38120013C>T	ENST00000406386.3	+	7	1705	c.1450C>T	c.(1450-1452)Cgg>Tgg	p.R484W	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	484					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CTGTGCCCAGCGGGACAATCC	0.602000													30	110					0	0	0.004878	0	0
BOD1L1	259282	broad.mit.edu	37	4	13603329	13603329	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:13603329G>C	ENST00000040738.5	-	10	5330	c.5195C>G	c.(5194-5196)gCa>gGa	p.A1732G		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1732							DNA binding										TCTGCCTTCTGCTCCTGTACA	0.502000													26	119					0	0	0.018920	0	0
OR1F2P	26184	broad.mit.edu	37	16	3266186	3266186	+	RNA	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:3266186C>A	ENST00000576468.1	+	0	418																											CAGACACACACCTCAGTGAAG	0.522000													32	31					5.45727e-16	6.69354e-16	0.008361	1	0
GLIS1	148979	broad.mit.edu	37	1	53980329	53980329	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:53980329G>T	ENST00000312233.2	-	7	1893	c.1327C>A	c.(1327-1329)Cct>Act	p.P443T		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	443					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						ATGGGCAGAGGGGACAGATGG	0.657000													7	46					0.00198382	0.00211199	0.001984	1	0
ST6GAL2	84620	broad.mit.edu	37	2	107460238	107460238	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:107460238G>T	ENST00000409382.3	-	2	806	c.196C>A	c.(196-198)Cat>Aat	p.H66N	ST6GAL2_ENST00000361686.4_Missense_Mutation_p.H66N|ST6GAL2_ENST00000409087.3_Missense_Mutation_p.H66N	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	66					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						GAGGGCTCATGTGCGGCGCCC	0.706000													7	39					5.4927e-09	6.34675e-09	0.004482	1	0
FAT2	2196	broad.mit.edu	37	5	150923577	150923577	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:150923577C>G	ENST00000261800.5	-	9	7123	c.7111G>C	c.(7111-7113)Gat>Cat	p.D2371H		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	2371	Cadherin 20.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCATTGATATCAGACACATTG	0.468000													20	60					0	0	0.010504	0	0
DOCK3	1795	broad.mit.edu	37	3	51198034	51198034	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:51198034A>G	ENST00000266037.9	+	12	961	c.938A>G	c.(937-939)tAc>tGc	p.Y313C		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	313						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CACCTGCACTACAGGCGACCA	0.493000													9	10					0	0	0.004482	0	0
OR2W3	343171	broad.mit.edu	37	1	248059253	248059253	+	Missense_Mutation	SNP	G	G	T	rs141229039	byFrequency	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:248059253G>T	ENST00000537741.1	+	3	622	c.365G>T	c.(364-366)cGg>cTg	p.R122L	OR2W3_ENST00000360358.3_Missense_Mutation_p.R122L			Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W, member 3	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	49	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCCTATGACCGGTGTGTGGCT	0.602000													21	48					6.33239e-15	7.71696e-15	0.010504	1	0
RNF139	11236	broad.mit.edu	37	8	125498769	125498769	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:125498769C>T	ENST00000303545.3	+	2	1251	c.879C>T	c.(877-879)ggC>ggT	p.G293G		NM_007218.3	NP_009149.2	Q8WU17	RN139_HUMAN	ring finger protein 139	293					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(1)	20	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			CTGTACTGGGCATGAGTGCTG	0.408000													11	157					0	0	0.016723	0	0
MYO15A	51168	broad.mit.edu	37	17	18051508	18051508	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:18051508C>T	ENST00000205890.5	+	31	7013	c.6675C>T	c.(6673-6675)gaC>gaT	p.D2225D		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	2225	Tail.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					TGGCGCTGGACGTGGGCTGCT	0.672000													5	34					0	0	0.001984	0	0
EPB41L3	23136	broad.mit.edu	37	18	5489114	5489114	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:5489114C>A	ENST00000341928.2	-	2	409	c.69G>T	c.(67-69)gcG>gcT	p.A23A	EPB41L3_ENST00000544123.1_Silent_p.A23A|EPB41L3_ENST00000540638.2_Silent_p.A23A|EPB41L3_ENST00000342933.3_Silent_p.A23A|EPB41L3_ENST00000400111.3_Silent_p.A23A	NM_012307.2	NP_036439.2	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	23					cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(24)|lung(52)|ovary(5)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	105						cctgcgcccccgccgccTCCT	0.687000													19	20					7.45023e-12	8.82386e-12	0.010504	1	0
FNBP1	23048	broad.mit.edu	37	9	132687277	132687277	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:132687277A>C	ENST00000420781.1	-	9	1167	c.949T>G	c.(949-951)Tcc>Gcc	p.S317A	FNBP1_ENST00000446176.2_Missense_Mutation_p.S317A|FNBP1_ENST00000355681.3_Missense_Mutation_p.S317A|FNBP1_ENST00000478129.1_5'UTR			Q96RU3	FNBP1_HUMAN	formin binding protein 1	317	Interaction with microtubules (By similarity).|Required for self-association and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding						Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		TTTCCTTTGGATTTGCCACCA	0.403000			T	MLL	AML								7	20					0	0	0.003080	0	0
OR6N2	81442	broad.mit.edu	37	1	158747203	158747203	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:158747203C>T	ENST00000339258.1	-	1	222	c.223G>A	c.(223-225)Gct>Act	p.A75T		NM_001005278.1	NP_001005278.1	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N, member 2	75					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(6)|lung(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_hematologic(112;0.0378)					ATAGTGGTAGCTGTATACCAC	0.443000													19	104					0	0	0.007413	0	0
AASS	10157	broad.mit.edu	37	7	121726194	121726194	+	Missense_Mutation	SNP	C	C	T	rs117830956	by1000genomes	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:121726194C>T	ENST00000393376.1	-	18	2151	c.2056G>A	c.(2056-2058)Gtt>Att	p.V686I	AASS_ENST00000417368.2_Missense_Mutation_p.V686I|AASS_ENST00000473553.1_5'UTR			Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase	686	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(6)|large_intestine(12)|lung(27)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	54					L-Glutamic Acid(DB00142)|NADH(DB00157)	ATGGACGTAACGGCATCAAGA	0.428000													4	39					0	0	0.009096	0	0
CORT	1325	broad.mit.edu	37	1	10510148	10510148	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:10510148C>T	ENST00000320498.4	+	1	178	c.18C>T	c.(16-18)aaC>aaT	p.N6N	APITD1-CORT_ENST00000465026.1_Intron|APITD1-CORT_ENST00000400900.2_Intron|APITD1-CORT_ENST00000470413.2_Intron|APITD1_ENST00000602296.1_Intron|CORT_ENST00000377049.3_5'UTR|APITD1_ENST00000602787.1_Intron					cortistatin											breast(1)|endometrium(1)|stomach(1)	3	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.0165)|READ - Rectum adenocarcinoma(331;0.0487)		GACACAAAAACAGCTGGAGAT	0.517000													33	112					0	0	0.009535	0	0
NINJ2	4815	broad.mit.edu	37	12	674430	674430	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:674430C>A	ENST00000305108.4	-	3	818	c.538G>T	c.(538-540)Gct>Tct	p.A180S	NINJ2_ENST00000397265.3_Missense_Mutation_p.A127S|NINJ2_ENST00000542920.1_Missense_Mutation_p.A98S	NM_016533.4	NP_057617.2	Q9NZG7	NINJ2_HUMAN	ninjurin 2	134					nervous system development|neuron cell-cell adhesion|tissue regeneration	integral to plasma membrane				large_intestine(3)|lung(1)|ovary(2)	6	all_cancers(10;0.0101)|all_epithelial(11;0.0174)|Ovarian(42;0.0512)|all_lung(10;0.103)|Lung NSC(10;0.185)		OV - Ovarian serous cystadenocarcinoma(31;3.26e-05)|BRCA - Breast invasive adenocarcinoma(9;0.0508)			GCCCTGGCAGCCAGGAACCCT	0.562000													15	35					0.000308642	0.000335173	0.003163	1	0
LPPR4	9890	broad.mit.edu	37	1	99772332	99772332	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:99772332G>C	ENST00000370185.3	+	7	2555	c.2058G>C	c.(2056-2058)aaG>aaC	p.K686N	LPPR4_ENST00000457765.1_Missense_Mutation_p.K628N|LPPR4_ENST00000370184.1_Missense_Mutation_p.K528N	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		686							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		GAGATCGCAAGAGAAGCAACA	0.512000													4	21					0	0	0.009096	0	0
XKR6	286046	broad.mit.edu	37	8	11058765	11058765	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:11058765G>A	ENST00000416569.2	-	1	110	c.84C>T	c.(82-84)ggC>ggT	p.G28G	XKR6_ENST00000297303.4_Silent_p.G28G	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	28	Gly-rich.					integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		CGTCCTCCTCGCCGCCGCTGC	0.716000													4	10					0	0	0.001168	0	0
DAAM1	23002	broad.mit.edu	37	14	59830421	59830421	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:59830421C>G	ENST00000395125.1	+	23	2800	c.2777C>G	c.(2776-2778)tCt>tGt	p.S926C	DAAM1_ENST00000360909.3_Missense_Mutation_p.S916C|DAAM1_ENST00000553966.1_3'UTR|DAAM1_ENST00000351081.1_Missense_Mutation_p.S926C	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	926	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AAGTTTGTGTCTGTTGTCAGC	0.463000													23	23					0	0	0.016522	0	0
AKAP11	11215	broad.mit.edu	37	13	42877626	42877626	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr13:42877626C>G	ENST00000025301.2	+	8	4919	c.4744C>G	c.(4744-4746)Ctt>Gtt	p.L1582V		NM_016248.3	NP_057332.1	Q9UKA4	AKA11_HUMAN	A kinase (PRKA) anchor protein 11	1582					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(2)	56		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		GTTGTCACCTCTTACAGGTCA	0.453000													17	18					0	0	0.004007	0	0
KRT10	3858	broad.mit.edu	37	17	38975393	38975393	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:38975393C>T	ENST00000269576.5	-	7	1403	c.1394G>A	c.(1393-1395)gGc>gAc	p.G465D	TMEM99_ENST00000301665.3_5'UTR	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	465	Gly-rich.|Tail.				epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				acttccgccgccgcgtccgcc	0.672000													11	22					0	0	0.013537	0	0
ZNF831	128611	broad.mit.edu	37	20	57767550	57767550	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:57767550C>G	ENST00000371030.2	+	1	1476	c.1476C>G	c.(1474-1476)ctC>ctG	p.L492L		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	492						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					CCACTCAGCTCTCCACCACCG	0.701000													24	59					0	0	0.018920	0	0
ITGA3	3675	broad.mit.edu	37	17	48166535	48166535	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:48166535T>C	ENST00000007722.7	+	25	3107	c.3107T>C	c.(3106-3108)aTc>aCc	p.I1036T	ITGA3_ENST00000320031.8_3'UTR			P26006	ITA3_HUMAN	integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)	1033					blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|leukocyte migration	cell surface|integrin complex	protein binding|receptor activity			endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	31						GCAGTGCGGATCCGGGAGGAG	0.562000													79	203					0	0	0.014410	0	0
SCAI	286205	broad.mit.edu	37	9	127904938	127904938	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:127904938C>G	ENST00000336505.5	-	2	130	c.72G>C	c.(70-72)gaG>gaC	p.E24D	SCAI_ENST00000373549.4_Missense_Mutation_p.E24D	NM_001144877.2	NP_001138349.1	Q8N9R8	SCAI_HUMAN	suppressor of cancer cell invasion	24	Necessary to inhibit MKL1-induced SRF transcriptional activity (By similarity).				negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|integral to membrane|nucleus	protein binding|transcription corepressor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(7)|large_intestine(4)|lung(8)|ovary(2)|pancreas(1)|prostate(5)|stomach(1)|urinary_tract(1)	35						GAGGCGGTTTCTCCACTGTGC	0.463000													4	32					0	0	0.009096	0	0
ZNF142	7701	broad.mit.edu	37	2	219509702	219509702	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:219509702T>G	ENST00000411696.2	-	7	2316	c.1537A>C	c.(1537-1539)Atg>Ctg	p.M513L	ZNF142_ENST00000449707.1_Missense_Mutation_p.M513L			P52746	ZN142_HUMAN	zinc finger protein 142	513					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		ACCTCACACATCAGAGACTTG	0.597000													26	49					0	0	0.004656	0	0
JPH2	57158	broad.mit.edu	37	20	42788372	42788372	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:42788372C>A	ENST00000372980.3	-	2	1927	c.1055G>T	c.(1054-1056)cGc>cTc	p.R352L		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	352					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CAGCATGCGGCGCTTGGTGTC	0.667000													15	40					6.49762e-13	7.76845e-13	0.006122	1	0
CDAN1	146059	broad.mit.edu	37	15	43020852	43020852	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:43020852C>T	ENST00000356231.3	-	20	2825	c.2802G>A	c.(2800-2802)cgG>cgA	p.R934R		NM_138477.2	NP_612486.2	Q8IWY9	CDAN1_HUMAN	codanin 1	934						integral to membrane	protein binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	24		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		CTGCTTACTCCCGCCCCAGGG	0.557000													18	42					0	0	0.010504	0	0
PTPRG	5793	broad.mit.edu	37	3	62240846	62240846	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:62240846G>A	ENST00000474889.1	+	16	2892	c.2515G>A	c.(2515-2517)Gag>Aag	p.E839K	PTPRG_ENST00000295874.10_Missense_Mutation_p.E810K	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	839					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		ACACATCGGTGAGCTCTATTC	0.373000													24	39					0	0	0.008361	0	0
ZNF852	285346	broad.mit.edu	37	3	44542105	44542105	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:44542105G>C	ENST00000436261.1	-	4	324	c.164C>G	c.(163-165)tCa>tGa	p.S55*	ZNF852_ENST00000489411.1_5'UTR			B6EU87	B6EU87_HUMAN	zinc finger protein 852	55					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)	8						AGTCAGCTCTGAACTCTCCAT	0.418000													6	20					0	0	0.001984	0	0
PCDH7	5099	broad.mit.edu	37	4	30725930	30725930	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:30725930G>A	ENST00000361762.2	+	1	3894	c.2886G>A	c.(2884-2886)caG>caA	p.Q962Q	PCDH7_ENST00000543491.1_Silent_p.Q962Q	NM_002589.2	NP_002580.2	O60245	PCDH7_HUMAN	protocadherin 7	962					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(8)|liver(1)|lung(26)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	55						CAAATGGACAGAGGTATGATA	0.473000													14	74					0	0	0.004990	0	0
CDS2	8760	broad.mit.edu	37	20	5159590	5159590	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:5159590C>G	ENST00000460006.1	+	5	824	c.517C>G	c.(517-519)Ctc>Gtc	p.L173V	CDS2_ENST00000379070.3_3'UTR|CDS2_ENST00000379062.4_Missense_Mutation_p.L53V|CDS2_ENST00000535100.1_5'UTR	NM_003818.3	NP_003809.1	O95674	CDS2_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2	173					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|stomach(1)	14						TTCCTTTACTCTCTATCTAAT	0.408000													31	49					0	0	0.013726	0	0
SLC7A13	157724	broad.mit.edu	37	8	87229783	87229783	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:87229783G>A	ENST00000297524.3	-	3	1198	c.1095C>T	c.(1093-1095)ttC>ttT	p.F365F	SLC7A13_ENST00000419776.2_Silent_p.F356F	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	365						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						ATGAACCCGTGAAAAAAATAT	0.338000													11	26					0	0	0.008291	0	0
D2HGDH	728294	broad.mit.edu	37	2	242690737	242690737	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:242690737G>A	ENST00000321264.4	+	8	1283	c.1074G>A	c.(1072-1074)ctG>ctA	p.L358L	D2HGDH_ENST00000403782.1_Silent_p.L224L|D2HGDH_ENST00000486953.1_Intron	NM_152783.3	NP_689996.4	Q8N465	D2HDH_HUMAN	D-2-hydroxyglutarate dehydrogenase	358					2-oxoglutarate metabolic process|cellular protein metabolic process|response to cobalt ion|response to manganese ion|response to zinc ion	mitochondrial matrix	(R)-2-hydroxyglutarate dehydrogenase activity|flavin adenine dinucleotide binding|protein binding			breast(1)|endometrium(3)|lung(10)|skin(1)|urinary_tract(1)	16		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		GCCACTTCCTGGAGCACGCGC	0.612000													21	27					0	0	0.014323	0	0
VPS54	51542	broad.mit.edu	37	2	64169644	64169644	+	Silent	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:64169644G>C	ENST00000354504.3	-	8	1483	c.894C>G	c.(892-894)ctC>ctG	p.L298L	VPS54_ENST00000409558.3_Silent_p.L439L|VPS54_ENST00000272322.4_Silent_p.L451L			Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	451					protein transport|retrograde transport, endosome to Golgi			p.L451L(1)		endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						AAATATCCTTGAGCAGATCAA	0.328000													12	12					0	0	0.003163	0	0
LILRP2	79166	broad.mit.edu	37	19	55222070	55222070	+	RNA	SNP	T	T	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:55222070T>A	ENST00000413439.1	+	0	1597																											AGCACCAGGCTGAATTCCCCA	0.597000													75	37					0	0	0.014410	0	0
USP15	9958	broad.mit.edu	37	12	62783422	62783422	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:62783422G>A	ENST00000280377.5	+	13	1653	c.1595G>A	c.(1594-1596)aGa>aAa	p.R532K	USP15_ENST00000353364.3_Missense_Mutation_p.R503K|USP15_ENST00000393654.3_Missense_Mutation_p.R507K	NM_001252078.1	NP_001239007.1	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	532					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(8)|lung(15)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	37			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		AGATTTCACAGAATATTCGCT	0.284000													19	92					0	0	0.010504	0	0
GLRA3	8001	broad.mit.edu	37	4	175598396	175598396	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:175598396C>T	ENST00000274093.3	-	7	1262	c.760G>A	c.(760-762)Gga>Aga	p.G254R	GLRA3_ENST00000340217.5_Missense_Mutation_p.G254R	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	254					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	AGATAGTATCCCATTTGTCGC	0.428000													7	28					0	0	0.003080	0	0
HRH2	3274	broad.mit.edu	37	5	175110317	175110317	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:175110317C>T	ENST00000231683.2	+	1	1854	c.81C>T	c.(79-81)gtC>gtT	p.V27V	HRH2_ENST00000377291.2_Silent_p.V27V	NM_022304.2	NP_071640.1	P25021	HRH2_HUMAN	histamine receptor H2	27					G-protein signaling, coupled to cyclic nucleotide second messenger|immune response	integral to plasma membrane	histamine receptor activity			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(10)|ovary(1)	22	all_cancers(89;0.00805)|Renal(175;0.000269)|Lung NSC(126;0.00419)|all_lung(126;0.00711)	Medulloblastoma(196;0.0208)|all_neural(177;0.0277)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)	Colorectal(1;0.0154)|COAD - Colon adenocarcinoma(1;0.149)	Betazole(DB00272)|Cimetidine(DB00501)|Doxepin(DB01142)|Epinastine(DB00751)|Famotidine(DB00927)|Histamine Phosphate(DB00667)|Nizatidine(DB00585)|Ranitidine(DB00863)	TCCTTGCGGTCCTCATCCTCA	0.582000													71	128					0	0	0.014410	0	0
FBXL20	84961	broad.mit.edu	37	17	37425091	37425091	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:37425091C>T	ENST00000264658.6	-	12	1182	c.922G>A	c.(922-924)Gag>Aag	p.E308K	FBXL20_ENST00000583610.1_Missense_Mutation_p.E308K|FBXL20_ENST00000577399.1_Missense_Mutation_p.E310K|FBXL20_ENST00000394294.3_Missense_Mutation_p.E276K	NM_032875.2	NP_116264.2	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	308						cytoplasm				breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22			LUAD - Lung adenocarcinoma(14;0.146)			TGAACACACTCTTCCAGGTCC	0.328000													28	223					0	0	0.009535	0	0
TAGLN2	8407	broad.mit.edu	37	1	159889539	159889539	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:159889539C>G	ENST00000368097.4	-	3	577	c.267G>C	c.(265-267)caG>caC	p.Q89H	TAGLN2_ENST00000478033.1_5'UTR|TAGLN2_ENST00000368096.1_Missense_Mutation_p.Q110H|TAGLN2_ENST00000320307.4_Missense_Mutation_p.Q89H	NM_001277223.1|NM_003564.1	NP_001264152.1|NP_003555.1	P37802	TAGL2_HUMAN	transgelin 2	89	CH.				muscle organ development	nuclear membrane|plasma membrane	protein binding			endometrium(1)|large_intestine(2)|lung(6)	9	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCTGCTCCATCTGCTTGAAGG	0.552000													66	138					0	0	0.014410	0	0
FKBP4	2288	broad.mit.edu	37	12	2907953	2907953	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:2907953G>A	ENST00000001008.4	+	4	662	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K	RP4-816N1.7_ENST00000547042.1_RNA|RP4-816N1.6_ENST00000547834.1_RNA	NM_002014.3	NP_002005.1	Q02790	FKBP4_HUMAN	FK506 binding protein 4, 59kDa	159					negative regulation of microtubule polymerization or depolymerization|negative regulation of neuron projection development|protein folding	axonal growth cone|cytosol|membrane|microtubule|nucleus	FK506 binding|heat shock protein binding|peptidyl-prolyl cis-trans isomerase activity|protein binding, bridging			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(3)|prostate(2)|skin(1)	14			OV - Ovarian serous cystadenocarcinoma(31;0.00105)		Dimethyl sulfoxide(DB01093)	GACTCGCGGTGAAGGCTATGC	0.483000													24	68					0	0	0.003954	0	0
NAV3	89795	broad.mit.edu	37	12	78593140	78593140	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:78593140G>T	ENST00000397909.2	+	37	6717	c.6544G>T	c.(6544-6546)Gaa>Taa	p.E2182*	NAV3_ENST00000266692.7_Nonsense_Mutation_p.E1983*|NAV3_ENST00000228327.6_Nonsense_Mutation_p.E2160*|NAV3_ENST00000536525.2_Nonsense_Mutation_p.E2160*|NAV3_ENST00000541270.1_Nonsense_Mutation_p.E12*			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2182						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						AAATCATACAGAACCAGTGAA	0.279000										HNSCC(70;0.22)			11	26					9.05144e-12	1.06869e-11	0.016723	1	0
SERPINA12	145264	broad.mit.edu	37	14	94962778	94962778	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:94962778C>A	ENST00000341228.2	-	4	1632	c.837G>T	c.(835-837)aaG>aaT	p.K279N	SERPINA12_ENST00000556881.1_Missense_Mutation_p.K279N	NM_173850.2	NP_776249.1	Q8IW75	SPA12_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12	279					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33				COAD - Colon adenocarcinoma(157;0.235)		AGTGCTTCAGCTTGCCCTCAT	0.473000													50	71					3.94638e-17	4.87191e-17	0.014410	1	0
CYP4F3	4051	broad.mit.edu	37	19	15760024	15760024	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:15760024C>T	ENST00000221307.7	+	6	628	c.580C>T	c.(580-582)Cac>Tac	p.H194Y	CYP4F3_ENST00000586182.1_Missense_Mutation_p.H194Y|CYP4F3_ENST00000591058.1_Missense_Mutation_p.H194Y|CYP4F3_ENST00000585846.1_Missense_Mutation_p.H194Y	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	194					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CATGTTTGAGCACATCAGCCT	0.577000													73	30					0	0	0.014410	0	0
DPP6	1804	broad.mit.edu	37	7	154659728	154659728	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:154659728G>A	ENST00000404039.1	+	18	2133	c.1546G>A	c.(1546-1548)Gaa>Aaa	p.E516K	DPP6_ENST00000332007.3_Missense_Mutation_p.E518K|DPP6_ENST00000427557.1_Missense_Mutation_p.E473K|DPP6_ENST00000377770.3_Missense_Mutation_p.E580K	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	580					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			AGAAACAAATGAACATGTCAA	0.438000													4	19					0	0	0.014758	0	0
UNC5D	137970	broad.mit.edu	37	8	35579764	35579764	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:35579764G>T	ENST00000287272.2	+	8	1006	c.986G>T	c.(985-987)gGc>gTc	p.G329V	UNC5D_ENST00000404895.2_Missense_Mutation_p.G385V|UNC5D_ENST00000420357.1_Missense_Mutation_p.G318V|UNC5D_ENST00000453357.2_Missense_Mutation_p.G380V|UNC5D_ENST00000416672.1_Missense_Mutation_p.G390V			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	385	TSP type-1 2.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		TTGTACTCGGGCTTGGGTGCT	0.522000													8	157					0.000274275	0.000299569	0.004482	1	0
SEMA6B	10501	broad.mit.edu	37	19	4548324	4548324	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:4548324A>G	ENST00000586582.1	-	13	1715	c.1405T>C	c.(1405-1407)Tct>Cct	p.S469P	SEMA6B_ENST00000301293.3_Missense_Mutation_p.S469P|SEMA6B_ENST00000586965.1_Missense_Mutation_p.S469P	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	469	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGAGCCCAGACGTCCCTGAG	0.647000													36	25					0	0	0.019004	0	0
OR5M10	390167	broad.mit.edu	37	11	56344765	56344765	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:56344765C>A	ENST00000526812.2	-	1	498	c.433G>T	c.(433-435)Gtc>Ttc	p.V145F		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						GGCACAGTGACCAGAGAGATG	0.438000													58	32					5.86059e-21	7.33057e-21	0.014410	1	0
FLCN	201163	broad.mit.edu	37	17	17131313	17131313	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:17131313C>G	ENST00000285071.4	-	4	593	c.139G>C	c.(139-141)Gaa>Caa	p.E47Q	FLCN_ENST00000389169.5_Missense_Mutation_p.E47Q|RP11-45M22.4_ENST00000427497.3_Missense_Mutation_p.E47Q	NM_144997.5	NP_659434.2	Q8NFG4	FLCN_HUMAN	folliculin	47					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(11)|stomach(1)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						CCTTCCTCTTCTTCCGCCTGC	0.652000									Familial Non-VHL Clear Cell Renal Cancer;Birt-Hogg-Dub syndrome				19	24					0	0	0.008871	0	0
FANCD2	2177	broad.mit.edu	37	3	10136010	10136010	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:10136010G>T	ENST00000287647.3	+	40	4019	c.3926G>T	c.(3925-3927)tGt>tTt	p.C1309F	FANCD2OS_ENST00000524279.1_Intron|FANCD2OS_ENST00000436517.1_Intron|FANCD2_ENST00000419585.1_Missense_Mutation_p.C1309F|FANCD2_ENST00000383806.1_3'UTR|FANCD2_ENST00000383807.1_Missense_Mutation_p.C1309F	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	1309					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		CTGAAGCAATGTATGCCGCTC	0.458000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				111	153					5.64391e-42	7.178e-42	0.014410	1	0
A4GNT	51146	broad.mit.edu	37	3	137843425	137843425	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:137843425C>G	ENST00000236709.3	-	3	905	c.704G>C	c.(703-705)tGg>tCg	p.W235S		NM_016161.2	NP_057245.1	Q9UNA3	A4GCT_HUMAN	alpha-1,4-N-acetylglucosaminyltransferase	235					protein O-linked glycosylation	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	acetylglucosaminyltransferase activity|galactosyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(7)	16						AAGTTTACACCATACCCTCAA	0.463000													24	56					0	0	0.014323	0	0
AOX1	316	broad.mit.edu	37	2	201515816	201515816	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:201515816G>A	ENST00000374700.2	+	26	3208	c.2967G>A	c.(2965-2967)agG>agA	p.R989R	AOX1_ENST00000485106.1_3'UTR	NM_001159.3	NP_001150.3	Q06278	ADO_HUMAN	aldehyde oxidase 1	989					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			breast(5)|endometrium(3)|kidney(4)|large_intestine(13)|lung(38)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	81					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	ACTCCTTGAGGAAAGTTGCTG	0.453000													21	134					0	0	0.014323	0	0
OR2H2	7932	broad.mit.edu	37	6	29556415	29556415	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:29556415C>T	ENST00000383640.2	+	1	733	c.694C>T	c.(694-696)Cgg>Tgg	p.R232W	GABBR1_ENST00000355973.3_Intron	NM_007160.3	NP_009091.3	O95918	OR2H2_HUMAN	olfactory receptor, family 2, subfamily H, member 2	232				KGR -> TAW (in Ref. 1; AAB36567).	defense response|mating|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(7)|prostate(1)|urinary_tract(1)	14						TGCAAAAGGGCGGAGGAAAGC	0.522000													10	85					0	0	0.006214	0	0
BCL9	607	broad.mit.edu	37	1	147091285	147091285	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:147091285C>A	ENST00000234739.3	+	8	2064	c.1324C>A	c.(1324-1326)Cca>Aca	p.P442T		NM_004326.2	NP_004317.2	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	442	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|large_intestine(2)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	7	all_hematologic(923;0.115)					ACCCTTTTCTCCAGATGAAAT	0.542000			T	"""IGH@, IGL@"""	B-ALL								16	38					3.45872e-05	3.82173e-05	0.004007	1	0
OR52B4	143496	broad.mit.edu	37	11	4388806	4388806	+	Silent	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:4388806G>C	ENST00000408920.2	-	1	810	c.720C>G	c.(718-720)ctC>ctG	p.L240L		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		CAAATGTGTTGAGAGCTTTGT	0.453000													13	29					0	0	0.013537	0	0
KRIT1	889	broad.mit.edu	37	7	91851243	91851243	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:91851243C>T	ENST00000394507.1	-	15	2319	c.1536G>A	c.(1534-1536)gtG>gtA	p.V512V	KRIT1_ENST00000340022.2_Silent_p.V512V|KRIT1_ENST00000412043.2_Silent_p.V512V|KRIT1_ENST00000394503.2_Silent_p.V464V|KRIT1_ENST00000394505.2_Silent_p.V512V	NM_194456.1	NP_919438.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	512	FERM.|Required for RAP1A binding.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(2)|stomach(1)	22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AGGGAAGTCTCACATCTCTTC	0.378000													83	94					0	0	0.014410	0	0
DNAH3	55567	broad.mit.edu	37	16	20996669	20996669	+	Silent	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:20996669T>C	ENST00000261383.3	-	48	7394	c.7395A>G	c.(7393-7395)gcA>gcG	p.A2465A	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2465	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		AGTCATTGCCTGCGTAGTTCT	0.537000													31	14					0	0	0.007291	0	0
RNF10	9921	broad.mit.edu	37	12	121001687	121001687	+	Missense_Mutation	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:121001687A>T	ENST00000325954.4	+	10	2067	c.1606A>T	c.(1606-1608)Agg>Tgg	p.R536W	RNF10_ENST00000413266.2_Missense_Mutation_p.R541W	NM_014868.4	NP_055683.3	Q8N5U6	RNF10_HUMAN	ring finger protein 10	536					negative regulation of Schwann cell proliferation|positive regulation of myelination|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription regulatory region DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)	27	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCCTGGAGAGGAGCCCCGA	0.567000													33	77					0	0	0.019004	0	0
TRIM4	89122	broad.mit.edu	37	7	99490035	99490035	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:99490035C>A	ENST00000355947.2	-	7	1383	c.1254G>T	c.(1252-1254)gcG>gcT	p.A418A	TRIM4_ENST00000349062.2_Silent_p.A392A	NM_033017.3	NP_148977.2	Q9C037	TRIM4_HUMAN	tripartite motif containing 4	418	B30.2/SPRY.				protein trimerization	cytoplasm|plasma membrane	zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(1)	17	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)	Ovarian(593;0.238)				TCCAATAAATCGCCCAGATGC	0.542000													80	958					2.94884e-30	3.72537e-30	0.014410	1	0
PICK1	9463	broad.mit.edu	37	22	38466861	38466861	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:38466861G>T	ENST00000404072.3	+	7	803	c.456G>T	c.(454-456)agG>agT	p.R152S	PICK1_ENST00000356976.3_Missense_Mutation_p.R152S|RP5-1039K5.13_ENST00000445483.1_RNA|PICK1_ENST00000468288.1_3'UTR	NM_001039583.1|NM_001039584.1	NP_001034672.1|NP_001034673.1	Q9NRD5	PICK1_HUMAN	protein interacting with PRKCA 1	152	AH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|DNA methylation involved in embryo development|DNA methylation involved in gamete generation|monoamine transport|neuronal ion channel clustering|protein phosphorylation|receptor clustering|retrograde vesicle-mediated transport, Golgi to ER|synaptic transmission	cell junction|endocytic vesicle membrane|Golgi apparatus|perinuclear region of cytoplasm|presynaptic membrane	ATPase activity|metal ion binding|protein C-terminus binding|protein kinase C binding|receptor binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	Melanoma(58;0.045)					TTGTCAAGAGGCTAGAGGAGC	0.627000													10	32					0.000673444	0.000727166	0.008291	1	0
ANO7	50636	broad.mit.edu	37	2	242140746	242140746	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:242140746C>T	ENST00000274979.8	+	7	853	c.750C>T	c.(748-750)ttC>ttT	p.F250F	ANO7_ENST00000402430.3_Silent_p.F249F	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	250						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						ACACCTTCTTCACAAGCACCA	0.592000													21	36					0	0	0.008871	0	0
CAPN5	726	broad.mit.edu	37	11	76833722	76833722	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:76833722C>G	ENST00000278559.3	+	12	1893	c.1704C>G	c.(1702-1704)ttC>ttG	p.F568L	CAPN5_ENST00000529629.1_Missense_Mutation_p.F568L|CAPN5_ENST00000531028.1_Intron|CAPN5_ENST00000456580.2_Missense_Mutation_p.F608L	NM_004055.4	NP_004046.2	O15484	CAN5_HUMAN	calpain 5	568	C2.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						AAGGCATCTTCTACCGCAAGA	0.582000													69	24					0	0	0.014410	0	0
DNAH3	55567	broad.mit.edu	37	16	21069459	21069459	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:21069459G>T	ENST00000261383.3	-	27	3871	c.3872C>A	c.(3871-3873)tCc>tAc	p.S1291Y	DNAH3_ENST00000415178.1_Missense_Mutation_p.S1291Y	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1291	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCAAAAGATGGAGGAGACACA	0.488000													8	44					0.00621372	0.00659663	0.006214	1	0
SIPA1L1	26037	broad.mit.edu	37	14	72169178	72169178	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:72169178C>T	ENST00000555818.1	+	12	3950	c.3602C>T	c.(3601-3603)aCg>aTg	p.T1201M	SIPA1L1_ENST00000358550.2_Missense_Mutation_p.T1201M|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.T1201M|SIPA1L1_ENST00000537413.1_Missense_Mutation_p.T676M|SIPA1L1_ENST00000554874.1_3'UTR	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1201					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GGAAAATCCACGCCTAGCTGG	0.478000													25	28					0	0	0.018920	0	0
TENC1	23371	broad.mit.edu	37	12	53452199	53452199	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:53452199C>A	ENST00000314250.6	+	15	1485	c.1195C>A	c.(1195-1197)Ccc>Acc	p.P399T	TENC1_ENST00000451358.1_Missense_Mutation_p.P399T|TENC1_ENST00000552570.1_Missense_Mutation_p.P399T|TENC1_ENST00000549700.1_Missense_Mutation_p.P399T|TENC1_ENST00000546602.1_Missense_Mutation_p.P399T|TENC1_ENST00000379902.3_Missense_Mutation_p.P275T|TENC1_ENST00000314276.3_Missense_Mutation_p.P409T	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	399	C2 tensin-type.				intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						GCTCACTTTCCCCAAGGACCA	0.627000													8	48					2.17888e-05	2.4146e-05	0.006214	1	0
ALPK3	57538	broad.mit.edu	37	15	85411403	85411403	+	Nonsense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:85411403C>T	ENST00000258888.5	+	14	5607	c.5440C>T	c.(5440-5442)Cag>Tag	p.Q1814*		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1814	Alpha-type protein kinase.				heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			CTCCTCCCACCAGTGCAATGC	0.632000													118	134					0	0	0.014410	0	0
PNPLA3	80339	broad.mit.edu	37	22	44322984	44322984	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:44322984C>T	ENST00000216180.3	+	2	530	c.357C>T	c.(355-357)acC>acT	p.T119T	PNPLA3_ENST00000423180.2_Silent_p.T115T|PNPLA3_ENST00000478713.1_3'UTR	NM_025225.2	NP_079501.2	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	119	Patatin.				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|prostate(1)|skin(1)|stomach(2)	19		Ovarian(80;0.024)|all_neural(38;0.0416)				TCTCTCTTACCAGAGTGTCTG	0.493000													20	46					0	0	0.014323	0	0
NTRK3	4916	broad.mit.edu	37	15	88423650	88423650	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:88423650G>A	ENST00000394480.1	-	18	2464	c.2143C>T	c.(2143-2145)Cac>Tac	p.H715Y	NTRK3_ENST00000357724.2_Missense_Mutation_p.H721Y|NTRK3_ENST00000355254.2_Missense_Mutation_p.H715Y|NTRK3_ENST00000557856.1_Missense_Mutation_p.H707Y|NTRK3_ENST00000360948.2_Missense_Mutation_p.H729Y	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	729	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCATGGTGTGTCCTCCCACC	0.507000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			4	51					0	0	0.014758	0	0
MEGF8	1954	broad.mit.edu	37	19	42861133	42861133	+	Splice_Site	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:42861133G>A	ENST00000334370.4	+	26	5264	c.4629_splice	c.e26+1	p.K1543_splice	MEGF8_ENST00000251268.6_Splice_Site_p.K1610_splice	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1610						integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GGCAGGAGAAGGTGAGCATCT	0.622000													5	9					0	0	0.001168	0	0
MED12	9968	broad.mit.edu	37	X	70340946	70340946	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:70340946G>C	ENST00000333646.6	+	5	878	c.679G>C	c.(679-681)Gag>Cag	p.E227Q	MED12_ENST00000374102.1_Missense_Mutation_p.E227Q|MED12_ENST00000374080.3_Missense_Mutation_p.E227Q	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	227					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					CCATGATGTAGAGGTGGCAAT	0.557000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						24	59					0	0	0.003954	0	0
OR4M1	441670	broad.mit.edu	37	14	20248685	20248685	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:20248685C>A	ENST00000315957.4	+	1	285	c.204C>A	c.(202-204)ctC>ctA	p.L68L		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCTGGCCCTCCTTGATATTT	0.423000													69	460					3.13743e-37	3.97688e-37	0.014410	1	0
RBM34	23029	broad.mit.edu	37	1	235318412	235318412	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:235318412C>T	ENST00000408888.3	-	4	611	c.381G>A	c.(379-381)gcG>gcA	p.A127A	RBM34_ENST00000366606.3_Silent_p.A122A			P42696	RBM34_HUMAN	RNA binding motif protein 34	127						nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			AATCAGCACTCGCTAGAGCGC	0.393000													22	33					0	0	0.018920	0	0
JUP	3728	broad.mit.edu	37	17	39777023	39777023	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:39777023G>A	ENST00000540235.1	-	9	1545	c.1546C>T	c.(1546-1548)Cgc>Tgc	p.R516C	KRT17_ENST00000311208.8_Missense_Mutation_p.R357C			P14923	PLAK_HUMAN	junction plakoglobin	0					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	23		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		ATCTCGCAGCGAAGCTGGGCC	0.627000													20	120					0	0	0.012319	0	0
ZNF184	7738	broad.mit.edu	37	6	27420788	27420788	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:27420788C>A	ENST00000211936.6	-	6	834	c.550G>T	c.(550-552)Ggg>Tgg	p.G184W	ZNF184_ENST00000377419.1_Missense_Mutation_p.G184W	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	184					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						ACACTTTTCCCAAATTCATTA	0.398000													21	146					1.9806e-07	2.24745e-07	0.014323	1	0
DDX26B	203522	broad.mit.edu	37	X	134679428	134679428	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:134679428G>C	ENST00000370752.4	+	3	604	c.270G>C	c.(268-270)caG>caC	p.Q90H	DDX26B_ENST00000493637.1_3'UTR	NM_182540.4	NP_872346.3	Q5JSJ4	DX26B_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26B	90	VWFA.									large_intestine(1)|lung(8)	9	Acute lymphoblastic leukemia(192;6.56e-05)					CTCTCGGTCAGGCTCTAAGAT	0.358000													30	40					0	0	0.007291	0	0
MLLT10	8028	broad.mit.edu	37	10	22016856	22016856	+	Splice_Site	SNP	C	C	G	rs138169869		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:22016856C>G	ENST00000377072.3	+	17	2458	c.2111_splice	c.e17+1	p.R704_splice	MLLT10_ENST00000377059.3_Splice_Site_p.R688_splice|MLLT10_ENST00000307729.7_Splice_Site_p.R688_splice|MLLT10_ENST00000446906.2_Splice_Site_p.R688_splice	NM_004641.3	NP_004632.1	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10	704					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						TCTCTCGCCACGGTAAGCGCT	0.423000			T	"""MLL, PICALM, CDK6"""	AL								7	14					0	0	0.003080	0	0
TMEM132E	124842	broad.mit.edu	37	17	32953546	32953546	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:32953546C>T	ENST00000321639.5	+	2	796	c.468C>T	c.(466-468)ttC>ttT	p.F156F		NM_207313.1	NP_997196.1	Q6IEE7	T132E_HUMAN	transmembrane protein 132E	156						integral to membrane				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(28)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	57				BRCA - Breast invasive adenocarcinoma(366;0.231)		GGGACGACTTCGGCGTCACCG	0.697000													8	65					0	0	0.006214	0	0
OR8S1	341568	broad.mit.edu	37	12	48920124	48920124	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:48920124C>T	ENST00000310194.1	+	1	710	c.710C>T	c.(709-711)gCc>gTc	p.A237V	OR8S1_ENST00000551654.1_Intron	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	237					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						AGAAGCAAGGCCTTCTCCACC	0.517000													17	71					0	0	0.004990	0	0
SCN1A	6323	broad.mit.edu	37	2	166930121	166930121	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:166930121G>A	ENST00000423058.2	-	1	28	c.11C>T	c.(10-12)aCa>aTa	p.T4I	AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000599041.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.T4I|SCN1A_ENST00000375405.3_Missense_Mutation_p.T4I|SCN1A_ENST00000303395.4_Missense_Mutation_p.T4I	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	4						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TACAAGCACTGTTTGCTCCAT	0.383000													25	85					0	0	0.005443	0	0
FAR2	55711	broad.mit.edu	37	12	29446406	29446406	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:29446406C>G	ENST00000182377.4	+	3	631	c.363C>G	c.(361-363)ctC>ctG	p.L121L	FAR2_ENST00000536681.2_Silent_p.L121L|RP11-996F15.2_ENST00000553105.1_RNA|FAR2_ENST00000547116.1_Silent_p.L24L	NM_018099.3	NP_060569.3	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	121					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						ACGACACTCTCAGGTACATTC	0.383000													9	122					0	0	0.006214	0	0
LRRC4B	94030	broad.mit.edu	37	19	51021288	51021288	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:51021288G>A	ENST00000599957.1	-	3	1879	c.1682C>T	c.(1681-1683)aCg>aTg	p.T561M	LRRC4B_ENST00000389201.3_Missense_Mutation_p.T561M			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	561						cell junction|integral to membrane|presynaptic membrane		p.T561M(1)		breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GGCGTTCTCCGTCACATCCGT	0.657000													12	27					0	0	0.010729	0	0
GALNT14	79623	broad.mit.edu	37	2	31165110	31165110	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:31165110C>T	ENST00000349752.5	-	9	1527	c.888G>A	c.(886-888)ggG>ggA	p.G296G	GALNT14_ENST00000420311.2_Silent_p.G261G|GALNT14_ENST00000356174.3_Silent_p.G263G|GALNT14_ENST00000324589.5_Silent_p.G301G|GALNT14_ENST00000486564.1_5'UTR|GALNT14_ENST00000406653.1_Silent_p.G276G	NM_024572.3	NP_078848.2	Q96FL9	GLT14_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)	296	Catalytic subdomain B.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(3)|large_intestine(10)|liver(1)|lung(21)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)	43	Acute lymphoblastic leukemia(172;0.155)					TATCATATTTCCCCAGGTAAT	0.493000													48	19					0	0	0.014410	0	0
SKP2	6502	broad.mit.edu	37	5	36166718	36166718	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:36166718C>T	ENST00000274255.6	+	4	686	c.490C>T	c.(490-492)Cgc>Tgc	p.R164C	SKP2_ENST00000274254.5_Missense_Mutation_p.R164C|SKP2_ENST00000508514.1_Intron|SKP2_ENST00000546211.1_5'UTR	NM_005983.3	NP_005974.2	Q13309	SKP2_HUMAN	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	164					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G1/S transition of mitotic cell cycle|S phase of mitotic cell cycle	nucleoplasm|SCF ubiquitin ligase complex	protein binding			breast(1)|central_nervous_system(2)|ovary(1)	4	all_lung(31;5.63e-05)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATTGCCTTCCGCTGCCCACG	0.453000													15	45					0	0	0.004990	0	0
EYS	346007	broad.mit.edu	37	6	66112465	66112465	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:66112465C>A	ENST00000503581.1	-	7	1627	c.1090G>T	c.(1090-1092)Gat>Tat	p.D364Y	EYS_ENST00000393380.2_Missense_Mutation_p.D364Y|EYS_ENST00000370616.2_Missense_Mutation_p.D364Y|EYS_ENST00000370618.3_Missense_Mutation_p.D364Y|EYS_ENST00000370621.3_Missense_Mutation_p.D364Y|EYS_ENST00000342421.5_Missense_Mutation_p.D364Y	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	364	EGF-like 4.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						CAAAGCAAATCTGTAAATATT	0.303000													16	29					4.7546e-09	5.51069e-09	0.004007	1	0
ARHGEF4	50649	broad.mit.edu	37	2	131797647	131797647	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:131797647G>A	ENST00000392953.3	+	7	1325	c.806G>A	c.(805-807)gGa>gAa	p.G269E	ARHGEF4_ENST00000409303.1_Missense_Mutation_p.G269E|ARHGEF4_ENST00000525839.1_Missense_Mutation_p.G269E|ARHGEF4_ENST00000326016.5_Missense_Mutation_p.G269E|ARHGEF4_ENST00000439368.2_3'UTR|ARHGEF4_ENST00000355771.3_Missense_Mutation_p.G198E|ARHGEF4_ENST00000428230.2_Intron	NM_032995.1	NP_127462.1	Q9NR80	ARHG4_HUMAN	Rho guanine nucleotide exchange factor (GEF) 4	269					apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|lamellipodium assembly|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|ruffle membrane	protein domain specific binding|Rac guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|cervix(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(3)|pancreas(1)|prostate(1)|skin(4)	29		Prostate(154;0.055)		BRCA - Breast invasive adenocarcinoma(221;0.097)		GGGAACAGCGGAGCGGAGGAC	0.672000													5	12					0	0	0.014758	0	0
ACIN1	22985	broad.mit.edu	37	14	23549790	23549790	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:23549790C>G	ENST00000262710.1	-	6	1255	c.928G>C	c.(928-930)Gag>Cag	p.E310Q	ACIN1_ENST00000605057.1_Missense_Mutation_p.E252Q|ACIN1_ENST00000555053.1_Missense_Mutation_p.E310Q|ACIN1_ENST00000457657.1_Missense_Mutation_p.E270Q	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	310	Glu-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		CTAGGTATCTCTTCCCCTTCT	0.458000													23	58					0	0	0.015359	0	0
C15orf54	400360	broad.mit.edu	37	15	39544847	39544847	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:39544847G>A	ENST00000318578.3	+	2	879	c.511G>A	c.(511-513)Gaa>Aaa	p.E171K	RP11-624L4.1_ENST00000558209.1_RNA|RP11-624L4.1_ENST00000561058.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA|C15orf54_ENST00000561223.1_Missense_Mutation_p.E171K	NM_207445.2	NP_997328.1	Q8N8G6	CO054_HUMAN	chromosome 15 open reading frame 54	171										NS(1)|haematopoietic_and_lymphoid_tissue(2)|lung(2)	5		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		TCATTTCATTGAAGTGTTCAA	0.453000													22	38					0	0	0.012319	0	0
SYNRG	11276	broad.mit.edu	37	17	35937553	35937553	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:35937553C>G	ENST00000339208.6	-	7	888	c.748G>C	c.(748-750)Gat>Cat	p.D250H	SYNRG_ENST00000394378.2_Intron|SYNRG_ENST00000585472.1_Intron|SYNRG_ENST00000502449.2_Intron|SYNRG_ENST00000346661.4_Missense_Mutation_p.D250H|SYNRG_ENST00000345615.4_Intron|SYNRG_ENST00000591288.1_Intron|SYNRG_ENST00000588194.1_Intron	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	250					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ACACATCCATCTACAGCAACC	0.438000													117	518					0	0	0.014410	0	0
KIRREL	55243	broad.mit.edu	37	1	158064493	158064493	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:158064493A>G	ENST00000368172.1	+	11	1311	c.1299A>G	c.(1297-1299)gcA>gcG	p.A433A	KIRREL_ENST00000359209.6_Silent_p.A619A|KIRREL_ENST00000360089.4_Silent_p.A455A|KIRREL_ENST00000368173.3_Silent_p.A635A|KIRREL_ENST00000392272.2_Silent_p.A516A|KIRREL_ENST00000416935.2_Silent_p.A519A			Q96J84	KIRR1_HUMAN	kin of IRRE like (Drosophila)	619	Ig-like C2-type 5.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(5)|skin(3)|stomach(1)	38	all_hematologic(112;0.0378)					CTTCCAGGGCAGTGCTCTATG	0.637000													7	49					0	0	0.001984	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140711485	140711485	+	Nonsense_Mutation	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:140711485A>T	ENST00000517417.1	+	1	1234	c.1234A>T	c.(1234-1236)Aga>Tga	p.R412*	PCDHGA1_ENST00000378105.3_Nonsense_Mutation_p.R412*	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACACTGGACAGAGAACTTAT	0.368000													24	34					0	0	0.003954	0	0
ANAPC4	29945	broad.mit.edu	37	4	25394003	25394003	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:25394003G>A	ENST00000315368.3	+	10	891	c.749G>A	c.(748-750)cGg>cAg	p.R250Q	ANAPC4_ENST00000510092.1_Missense_Mutation_p.R250Q	NM_013367.2	NP_037499.2	Q9UJX5	APC4_HUMAN	anaphase promoting complex subunit 4	250					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	protein phosphatase binding|ubiquitin-protein ligase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(2)	27		Breast(46;0.0503)				GAAGTAACTCGGATGGCCAGA	0.343000													11	52					0	0	0.016723	0	0
USPL1	10208	broad.mit.edu	37	13	31205581	31205581	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr13:31205581C>G	ENST00000255304.4	+	4	1180	c.838C>G	c.(838-840)Cta>Gta	p.L280V	USPL1_ENST00000465952.1_3'UTR	NM_005800.4	NP_005791.3	Q5W0Q7	USPL1_HUMAN	ubiquitin specific peptidase like 1	280					ubiquitin-dependent protein catabolic process		ubiquitin thiolesterase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(15)|pancreas(3)|skin(3)	34		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0306)|Epithelial(112;0.131)|OV - Ovarian serous cystadenocarcinoma(117;0.134)		AAATACACTTCTATATACCAG	0.373000													24	11					0	0	0.016522	0	0
TRO	7216	broad.mit.edu	37	X	54956769	54956769	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:54956769C>A	ENST00000173898.7	+	12	3724	c.3612C>A	c.(3610-3612)agC>agA	p.S1204R	TRO_ENST00000375022.4_Intron|TRO_ENST00000319167.8_Intron|TRO_ENST00000420798.2_Missense_Mutation_p.S735R|TRO_ENST00000399736.1_Intron|TRO_ENST00000375041.2_Missense_Mutation_p.S807R	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	1204	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						ATGGGTTAAGCACCAATGCTG	0.552000													23	14					3.62473e-10	4.24004e-10	0.012319	1	0
OR4X2	119764	broad.mit.edu	37	11	48267148	48267148	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:48267148G>A	ENST00000302329.3	+	1	541	c.493G>A	c.(493-495)Gtg>Atg	p.V165M		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						TGGCCCCAATGTGATCAATCA	0.493000													78	191					0	0	0.014410	0	0
PXDN	7837	broad.mit.edu	37	2	1657494	1657494	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:1657494A>G	ENST00000252804.4	-	16	2060	c.2010T>C	c.(2008-2010)gtT>gtC	p.V670V		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	670					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTGCCTGTTCAACTGTGTAAG	0.498000													4	2					0	0	0.009096	0	0
DISP1	84976	broad.mit.edu	37	1	223176456	223176456	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:223176456G>A	ENST00000284476.6	+	8	1881	c.1717G>A	c.(1717-1719)Gat>Aat	p.D573N		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	573	SSD.				diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		TGGAGCAGATGATGCTTTTGT	0.403000													32	60					0	0	0.008361	0	0
HSD3B7	80270	broad.mit.edu	37	16	30999232	30999232	+	Nonsense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:30999232G>T	ENST00000297679.5	+	7	931	c.838G>T	c.(838-840)Gga>Tga	p.G280*	HSD3B7_ENST00000353250.5_3'UTR|HSD3B7_ENST00000262520.6_3'UTR	NM_025193.3	NP_079469.2	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	280					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						GGGCCCCTGCGGACTGCGGCT	0.642000													114	76					4.37143e-48	5.57835e-48	0.014410	1	0
ZNF77	58492	broad.mit.edu	37	19	2934107	2934107	+	Nonsense_Mutation	SNP	G	G	A	rs146879198	byFrequency	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:2934107G>A	ENST00000314531.4	-	4	1110	c.1018C>T	c.(1018-1020)Cga>Tga	p.R340*		NM_021217.2	NP_067040.1	Q15935	ZNF77_HUMAN	zinc finger protein 77	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(5)|ovary(1)	17				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|GBM - Glioblastoma multiforme(1328;2.11e-07)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.174)|STAD - Stomach adenocarcinoma(1328;0.18)		CCATGTTCTCGAAGAGACGAG	0.493000													24	47					0	0	0.014323	0	0
KIAA0368	23392	broad.mit.edu	37	9	114133964	114133964	+	Silent	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:114133964T>C	ENST00000259335.4	-	44	5207	c.5208A>G	c.(5206-5208)ccA>ccG	p.P1736P	KIAA0368_ENST00000374378.3_Silent_p.P22P|KIAA0368_ENST00000338205.5_Silent_p.P1558P	NM_001080398.1	NP_001073867.1			KIAA0368											NS(2)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(23)|prostate(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	65						TTCCGAGATATGGAGGTACTA	0.483000													78	88					0	0	0.014410	0	0
OTOR	56914	broad.mit.edu	37	20	16730565	16730565	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:16730565G>T	ENST00000246081.2	+	3	317	c.273G>T	c.(271-273)caG>caT	p.Q91H	OTOR_ENST00000486129.1_3'UTR	NM_020157.2	NP_064542.1	Q9NRC9	OTOR_HUMAN	otoraplin	91	SH3.				sensory perception of sound	extracellular region				breast(1)|central_nervous_system(1)|endometrium(1)|liver(4)|lung(1)|ovary(1)|upper_aerodigestive_tract(1)	10						GTGATGGCCAGGACGAGATGG	0.502000													5	25					0.00116845	0.00125451	0.001168	1	0
PCED1A	64773	broad.mit.edu	37	20	2816190	2816190	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:2816190C>A	ENST00000360652.2	-	8	1785	c.1283G>T	c.(1282-1284)cGg>cTg	p.R428L	PCED1A_ENST00000356872.3_Missense_Mutation_p.R377L	NM_022760.3	NP_073597.2			PC-esterase domain containing 1A																		GTGTCTGAGCCGCTGCCTGCA	0.622000													39	22					1.07121e-22	1.3488e-22	0.006999	1	0
MAP1LC3C	440738	broad.mit.edu	37	1	242162301	242162301	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:242162301G>C	ENST00000357246.3	-	1	74	c.10C>G	c.(10-12)Cca>Gca	p.P4A		NM_001004343.2	NP_001004343.1	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3 gamma	4					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			endometrium(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			ATTTTCTGTGGAGGCGGCATT	0.468000											OREG0014354	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	56					0	0	0.016522	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27886720	27886720	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:27886720G>A	ENST00000326019.6	+	1	383	c.101G>A	c.(100-102)aGg>aAg	p.R34K		NM_018158.2	NP_060628.2	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger), member 1, adaptor protein	34						cytoplasm|nucleus	double-stranded RNA binding|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.155)					GACGTGGACAGGAACGTAAAG	0.572000													21	80					0	0	0.008871	0	0
LIN28B	389421	broad.mit.edu	37	6	105406144	105406144	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:105406144G>A	ENST00000345080.4	+	2	384	c.181G>A	c.(181-183)Gat>Aat	p.D61N		NM_001004317.3	NP_001004317.1	Q6ZN17	LN28B_HUMAN	lin-28 homolog B (C. elegans)	61	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			large_intestine(1)|lung(10)|ovary(1)	12		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				TATTCCAGTCGATGTATTTGT	0.458000													6	66					0	0	0.001984	0	0
GDF3	9573	broad.mit.edu	37	12	7848123	7848123	+	Nonsense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:7848123G>A	ENST00000329913.3	-	1	249	c.202C>T	c.(202-204)Cga>Tga	p.R68*		NM_020634.1	NP_065685.1	Q9NR23	GDF3_HUMAN	growth differentiation factor 3	68					eye development|growth|skeletal system development	extracellular space	cytokine activity|growth factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	28						CATAAGTCTCGGGAGACCCCA	0.498000													6	71					0	0	0.001168	0	0
GPRC5D	55507	broad.mit.edu	37	12	13102817	13102817	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:13102817C>T	ENST00000228887.1	-	1	501	c.502G>A	c.(502-504)Gtg>Atg	p.V168M	RP11-392P7.6_ENST00000536029.1_RNA|RP11-392P7.6_ENST00000543515.2_RNA|RP11-392P7.6_ENST00000542078.1_RNA|RP11-392P7.6_ENST00000394742.3_RNA|RP11-392P7.6_ENST00000540198.1_RNA|RP11-392P7.6_ENST00000545914.1_RNA|GPRC5D_ENST00000396333.3_Missense_Mutation_p.V168M	NM_018654.1	NP_061124.1	Q9NZD1	GPC5D_HUMAN	G protein-coupled receptor, family C, group 5, member D	168						integral to membrane|plasma membrane	G-protein coupled receptor activity			kidney(2)|large_intestine(2)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		ACAAAGTCCACATTGAGCTGG	0.478000													11	55					0	0	0.008291	0	0
SGCE	8910	broad.mit.edu	37	7	94228233	94228233	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:94228233C>G	ENST00000415788.2	-	10	1302	c.1215G>C	c.(1213-1215)aaG>aaC	p.K405N	SGCE_ENST00000447873.1_Missense_Mutation_p.K360N|SGCE_ENST00000445866.2_Missense_Mutation_p.K369N|SGCE_ENST00000265735.7_Missense_Mutation_p.K369N|SGCE_ENST00000437425.2_Missense_Mutation_p.K328N|SGCE_ENST00000428696.2_Missense_Mutation_p.K360N			O43556	SGCE_HUMAN	sarcoglycan, epsilon	369					cell-matrix adhesion|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma	calcium ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|skin(1)	14	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CTCGAAGCTCCTTGGTAGATT	0.418000													17	164					0	0	0.004990	0	0
IGLV3-22	28795	broad.mit.edu	37	22	23047125	23047125	+	RNA	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:23047125C>A	ENST00000390307.2	+	0	227																											TGACTGGTACCAGCAGAAGCC	0.557000													6	43					8.12818e-05	8.92922e-05	0.001984	1	0
PDE6B	5158	broad.mit.edu	37	4	654380	654380	+	Missense_Mutation	SNP	G	G	A	rs144664551		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:654380G>A	ENST00000255622.6	+	12	1635	c.1592G>A	c.(1591-1593)cGa>cAa	p.R531Q	PDE6B_ENST00000429163.2_Missense_Mutation_p.R252Q|PDE6B_ENST00000496514.1_Missense_Mutation_p.R531Q	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	531					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						GGCGTGGTCCGAAAGTTCCAG	0.587000													5	26					0	0	0.001984	0	0
OR51B5	282763	broad.mit.edu	37	11	5364617	5364617	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:5364617G>A	ENST00000300773.2	-	1	192	c.138C>T	c.(136-138)ctC>ctT	p.L46L	HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001005567.2	NP_001005567.2	Q9H339	O51B5_HUMAN	olfactory receptor, family 51, subfamily B, member 5	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	28		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.05e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCCTTAATGAGAAGAAGGA	0.493000													15	22					0	0	0.003163	0	0
SSH2	85464	broad.mit.edu	37	17	27959598	27959598	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:27959598C>T	ENST00000269033.3	-	15	2684	c.2533G>A	c.(2533-2535)Gag>Aag	p.E845K	SSH2_ENST00000540801.1_Missense_Mutation_p.E872K|RP11-68I3.2_ENST00000581474.1_RNA	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	845					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGTTCCCCCTCAGCTGGTTCC	0.577000													23	177					0	0	0.014323	0	0
PSMD14	10213	broad.mit.edu	37	2	162242025	162242025	+	Silent	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:162242025A>C	ENST00000409682.3	+	8	1217	c.513A>C	c.(511-513)ggA>ggC	p.G171G		NM_005805.5	NP_005796.1	O00487	PSDE_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	171					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K63-linked deubiquitination|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of proteasomal protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	endopeptidase activator activity|metal ion binding|metallopeptidase activity|proteasome binding|ubiquitin thiolesterase activity			breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)	12						TGGTCTTAGGACATGAACCAA	0.318000													7	24					0	0	0.003080	0	0
AP1S3	130340	broad.mit.edu	37	2	224642491	224642491	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:224642491C>A	ENST00000443700.1	-	2	250	c.99G>T	c.(97-99)cgG>cgT	p.R33R	AP1S3_ENST00000396653.2_Silent_p.R33R|AP1S3_ENST00000396654.2_Silent_p.R33R|AP1S3_ENST00000409375.1_Silent_p.R33R|AP1S3_ENST00000446015.2_Silent_p.R33R|AP1S3_ENST00000423110.1_Silent_p.R33R			Q96PC3	AP1S3_HUMAN	adaptor-related protein complex 1, sigma 3 subunit	33					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane coat	protein transporter activity			NS(1)|breast(1)|lung(2)	4		Renal(207;0.0112)|Lung NSC(271;0.0186)|all_lung(227;0.0272)		Epithelial(121;7.6e-10)|all cancers(144;3.62e-07)|Lung(261;0.0086)|LUSC - Lung squamous cell carcinoma(224;0.00902)		GAACAATTTCCCGGGTGATCT	0.403000													19	27					0.00074312	0.000800121	0.006122	1	0
SNX14	57231	broad.mit.edu	37	6	86227558	86227558	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:86227558G>A	ENST00000314673.3	-	23	2360	c.2184C>T	c.(2182-2184)ttC>ttT	p.F728F	SNX14_ENST00000513865.1_Silent_p.F447F|SNX14_ENST00000369627.2_Silent_p.F719F|SNX14_ENST00000346348.3_Silent_p.F675F|SNX14_ENST00000508980.1_5'UTR|SNX14_ENST00000505648.1_Silent_p.F676F	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	728					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity	p.F728F(1)		NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		AAGAATTAATGAAATTCATGA	0.343000													5	36					0	0	0.014758	0	0
PDPR	55066	broad.mit.edu	37	16	70166109	70166109	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:70166109G>T	ENST00000288050.4	+	9	1860	c.903G>T	c.(901-903)ctG>ctT	p.L301L	PDPR_ENST00000568530.1_Silent_p.L301L|PDPR_ENST00000398122.3_Silent_p.L201L|PDPR_ENST00000562100.1_3'UTR	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	301					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		GTGGCATCCTGTCTGGGGGCT	0.468000													23	59					3.62531e-18	4.49017e-18	0.019004	1	0
LPPR4	9890	broad.mit.edu	37	1	99771294	99771294	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:99771294C>A	ENST00000370185.3	+	7	1517	c.1020C>A	c.(1018-1020)caC>caA	p.H340Q	LPPR4_ENST00000457765.1_Missense_Mutation_p.H282Q|LPPR4_ENST00000370184.1_Missense_Mutation_p.H182Q	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		340							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		TGTTTCAGCACAGAGACGCCC	0.448000													36	52					1.36239e-07	1.55059e-07	0.015359	1	0
ATP10D	57205	broad.mit.edu	37	4	47514737	47514737	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:47514737C>G	ENST00000273859.3	+	2	449	c.180C>G	c.(178-180)ttC>ttG	p.F60L	ATP10D_ENST00000504445.1_Missense_Mutation_p.F60L	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	60					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						TCCAGCCCTTCAAGGATGAGT	0.463000													11	50					0	0	0.010729	0	0
LZTS1	11178	broad.mit.edu	37	8	20110540	20110540	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:20110540C>T	ENST00000381569.1	-	3	1259	c.902G>A	c.(901-903)cGc>cAc	p.R301H	LZTS1_ENST00000265801.6_Missense_Mutation_p.R301H|LZTS1_ENST00000522290.1_Missense_Mutation_p.R301H			Q9Y250	LZTS1_HUMAN	leucine zipper, putative tumor suppressor 1	301					cell cycle|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	cell junction|dendritic spine|Golgi apparatus|nucleolus|nucleoplasm|postsynaptic density|postsynaptic membrane	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(2)|skin(1)|urinary_tract(1)	29				Colorectal(74;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GTCCCTGCAGCGCCGCGGCCG	0.682000													11	47					0	0	0.008291	0	0
TOE1	114034	broad.mit.edu	37	1	45808899	45808899	+	Missense_Mutation	SNP	C	C	T	rs145913038		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:45808899C>T	ENST00000372090.5	+	8	1641	c.1058C>T	c.(1057-1059)cCg>cTg	p.P353L	TOE1_ENST00000495703.1_3'UTR|TOE1_ENST00000539779.1_Missense_Mutation_p.P273L	NM_025077.3	NP_079353.3	Q96GM8	TOE1_HUMAN	target of EGR1, member 1 (nuclear)	353						nuclear speck|nucleolus	nucleic acid binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	11	Acute lymphoblastic leukemia(166;0.155)					TTGAACCTACCGGGGACACAG	0.557000													22	94					0	0	0.012319	0	0
ABCC9	10060	broad.mit.edu	37	12	22005368	22005368	+	Silent	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:22005368C>A	ENST00000261200.4	-	21	2576	c.2577G>T	c.(2575-2577)ctG>ctT	p.L859L	ABCC9_ENST00000345162.2_Silent_p.L823L|ABCC9_ENST00000261201.4_Silent_p.L859L|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	859	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TGTCATCTTGCAGGAATTTCA	0.403000													7	73					1.06961e-07	1.22103e-07	0.003080	1	0
SPHKAP	80309	broad.mit.edu	37	2	228996711	228996711	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:228996711G>A	ENST00000392056.3	-	2	169	c.123C>T	c.(121-123)atC>atT	p.I41I	SPHKAP_ENST00000344657.5_Silent_p.I41I	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	41						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TACAGGCTGTGATGGAGTTCC	0.468000													26	96					0	0	0.004656	0	0
TPTEP1	387590	broad.mit.edu	37	22	17119558	17119558	+	RNA	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:17119558A>T	ENST00000426585.1	+	0	370																											ATTCCTTCGGAGTATCGTTCT	0.353000													17	33					0	0	0.006122	0	0
SPRTN	83932	broad.mit.edu	37	1	231487114	231487114	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:231487114C>T	ENST00000391858.4	+	4	1795	c.515C>T	c.(514-516)cCg>cTg	p.P172L	SPRTN_ENST00000469904.1_3'UTR|SPRTN_ENST00000008440.9_Missense_Mutation_p.P129L|SPRTN_ENST00000295050.7_Missense_Mutation_p.P172L					SprT-like N-terminal domain																		TGCAATGGGCCGTGCCAGCAC	0.498000													13	50					0	0	0.016723	0	0
USP29	57663	broad.mit.edu	37	19	57640670	57640670	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:57640670C>G	ENST00000254181.4	+	4	1081	c.627C>G	c.(625-627)aaC>aaG	p.N209K	USP29_ENST00000598197.1_Missense_Mutation_p.N209K	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	209					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATAGGAAGAACCCATCAAGTT	0.353000													10	54					0	0	0.008291	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37188009	37188009	+	RNA	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:37188009C>T	ENST00000425901.2	+	0	1851					NR_033753.2																						TATTATGAGACGTCCATGCCA	0.507000													15	100					0	0	0.003163	0	0
WWC1	23286	broad.mit.edu	37	5	167826495	167826495	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:167826495C>T	ENST00000265293.4	+	5	1015	c.513C>T	c.(511-513)gtC>gtT	p.V171V	WWC1_ENST00000521089.1_Silent_p.V171V	NM_001161661.1|NM_001161662.1|NM_015238.2	NP_001155133.1|NP_001155134.1|NP_056053.1	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1	171					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(1)|skin(4)	43	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		CCCTCCAGGTCAACAAGCTGA	0.577000													9	29					0	0	0.006214	0	0
CDK12	51755	broad.mit.edu	37	17	37619117	37619117	+	Missense_Mutation	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:37619117A>C	ENST00000447079.4	+	1	826	c.793A>C	c.(793-795)Agt>Cgt	p.S265R	CDK12_ENST00000430627.2_Missense_Mutation_p.S265R	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	265					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						CTACAAGAAAAGTCCTGGAAG	0.537000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			29	304					0	0	0.006320	0	0
CACNA1C	775	broad.mit.edu	37	12	2760808	2760808	+	Silent	SNP	C	C	T	rs150092451	by1000genomes	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:2760808C>T	ENST00000399655.1	+	32	4213	c.3948C>T	c.(3946-3948)aaC>aaT	p.N1316N	CACNA1C_ENST00000399644.1_Silent_p.N1316N|CACNA1C_ENST00000399597.1_Silent_p.N1316N|CACNA1C_ENST00000399595.1_Silent_p.N1305N|CACNA1C_ENST00000399641.1_Silent_p.N1316N|CACNA1C_ENST00000347598.4_Silent_p.N1364N|CACNA1C_ENST00000399629.1_Silent_p.N1333N|CACNA1C_ENST00000399649.1_Silent_p.N1303N|CACNA1C_ENST00000399634.1_Silent_p.N1316N|CACNA1C_ENST00000335762.5_Silent_p.N1341N|CACNA1C_ENST00000399601.1_Silent_p.N1316N|CACNA1C_ENST00000399637.1_Silent_p.N1316N|CACNA1C_ENST00000399638.1_Silent_p.N1344N|CACNA1C_ENST00000399617.1_Silent_p.N1316N|CACNA1C_ENST00000406454.3_Silent_p.N1316N|CACNA1C_ENST00000399591.1_Silent_p.N1305N|CACNA1C_ENST00000344100.3_Silent_p.N1338N|CACNA1C_ENST00000402845.3_Silent_p.N1316N|CACNA1C_ENST00000399603.1_Silent_p.N1316N|CACNA1C_ENST00000327702.7_Silent_p.N1316N|CACNA1C_ENST00000399621.1_Silent_p.N1316N|CACNA1C_ENST00000399606.1_Silent_p.N1336N	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1364					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity	p.N851N(1)|p.N1394N(1)		NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGTTCCAGAACGCAGAGGAAA	0.617000													28	73					0	0	0.013726	0	0
GPC6	10082	broad.mit.edu	37	13	95050757	95050757	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr13:95050757C>A	ENST00000377047.4	+	8	1942	c.1327C>A	c.(1327-1329)Cag>Aag	p.Q443K		NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	443						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GCTCACCAACCAGATCAACAA	0.478000													19	20					7.87624e-14	9.50668e-14	0.016522	1	0
ACIN1	22985	broad.mit.edu	37	14	23530555	23530555	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:23530555G>T	ENST00000262710.1	-	17	3877	c.3550C>A	c.(3550-3552)Cgc>Agc	p.R1184S	ACIN1_ENST00000605057.1_Missense_Mutation_p.R1126S|ACIN1_ENST00000555053.1_Missense_Mutation_p.R1171S|ACIN1_ENST00000557515.1_Missense_Mutation_p.R425S|ACIN1_ENST00000457657.1_Missense_Mutation_p.R1144S|ACIN1_ENST00000338631.6_Missense_Mutation_p.R457S|ACIN1_ENST00000357481.2_Missense_Mutation_p.R426S|ACIN1_ENST00000397341.3_Missense_Mutation_p.R426S	NM_001164814.1|NM_014977.3	NP_001158286.1|NP_055792.1	Q9UKV3	ACINU_HUMAN	apoptotic chromatin condensation inducer 1	1184	Arg/Asp/Glu/Lys-rich.				apoptotic chromosome condensation|erythrocyte differentiation|positive regulation of monocyte differentiation	cytosol	ATPase activity|enzyme binding|nucleic acid binding|nucleotide binding			breast(1)|endometrium(6)|kidney(4)|large_intestine(9)|lung(10)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	37	all_cancers(95;1.36e-05)			GBM - Glioblastoma multiforme(265;0.00816)		TCCTTGCGGCGGCGGTCACGG	0.562000													16	82					0.000308642	0.000335173	0.003163	1	0
IFIH1	64135	broad.mit.edu	37	2	163124634	163124634	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:163124634C>G	ENST00000263642.2	-	14	3165	c.2770G>C	c.(2770-2772)Gag>Cag	p.E924Q		NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	924					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						TGCATTTTCTCAATTACATGG	0.388000													6	41					0	0	0.001168	0	0
CYB561	1534	broad.mit.edu	37	17	61511886	61511886	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:61511886G>A	ENST00000392976.1	-	6	932	c.633C>T	c.(631-633)ttC>ttT	p.F211F	CYB561_ENST00000392975.2_Silent_p.F211F|CYB561_ENST00000584031.1_3'UTR|CYB561_ENST00000448884.2_3'UTR|CYB561_ENST00000581573.1_Silent_p.F211F|CYB561_ENST00000582997.1_Silent_p.F218F|CYB561_ENST00000360793.3_Silent_p.F211F|CYB561_ENST00000582297.1_Intron|CYB561_ENST00000582034.1_Silent_p.F182F|CYB561_ENST00000581163.1_5'UTR|CYB561_ENST00000542042.1_Silent_p.F278F	NM_001017916.1	NP_001017916.1	P49447	CY561_HUMAN	cytochrome b561	211	Cytochrome b561.				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			lung(2)|ovary(1)|prostate(1)	4				READ - Rectum adenocarcinoma(1115;0.0689)		CCGCCCCACCGAAGCAGGCCA	0.652000													5	36					0	0	0.014758	0	0
MADD	8567	broad.mit.edu	37	11	47315475	47315475	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:47315475G>C	ENST00000342922.4	+	20	3700	c.3343G>C	c.(3343-3345)Gag>Cag	p.E1115Q	MADD_ENST00000407859.3_Missense_Mutation_p.E1092Q|MADD_ENST00000406482.1_Missense_Mutation_p.E1072Q|MADD_ENST00000405573.2_5'UTR|MADD_ENST00000402799.1_Missense_Mutation_p.E1072Q|MADD_ENST00000402192.2_Missense_Mutation_p.E1115Q|MADD_ENST00000395336.3_Missense_Mutation_p.E1153Q|MADD_ENST00000395344.3_Missense_Mutation_p.E1072Q|MADD_ENST00000349238.3_Missense_Mutation_p.E1135Q|MADD_ENST00000311027.5_Missense_Mutation_p.E1153Q	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	1153					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		TGGTGAGACAGAGGAGAAAAA	0.478000													16	31					0	0	0.008871	0	0
PRDM15	63977	broad.mit.edu	37	21	43280475	43280475	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:43280475C>G	ENST00000422911.1	-	2	210	c.109G>C	c.(109-111)Gag>Cag	p.E37Q	PRDM15_ENST00000398548.1_Missense_Mutation_p.E37Q|PRDM15_ENST00000447207.2_5'UTR|PRDM15_ENST00000538201.1_5'UTR|PRDM15_ENST00000269844.3_Missense_Mutation_p.E300Q			P57071	PRD15_HUMAN	PR domain containing 15	300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						TCAGCCATCTCTGACACCTGT	0.463000													25	17					0	0	0.008361	0	0
GHRH	2691	broad.mit.edu	37	20	35885254	35885254	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:35885254G>A	ENST00000373614.2	-	2	150	c.39C>T	c.(37-39)ctC>ctT	p.L13L	GHRH_ENST00000237527.3_Silent_p.L13L|GHRH_ENST00000373611.2_Silent_p.L13L			P01286	SLIB_HUMAN	growth hormone releasing hormone	13					activation of adenylate cyclase activity by G-protein signaling pathway|adenohypophysis development|growth hormone secretion|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of circadian sleep/wake cycle, REM sleep|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to food	extracellular space|terminal button	growth hormone-releasing hormone activity|growth hormone-releasing hormone receptor binding			lung(1)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	4		Myeloproliferative disorder(115;0.00878)				AGCTGTTGCTGAGGGTGAGGA	0.612000													6	31					0	0	0.003080	0	0
OR4S2	219431	broad.mit.edu	37	11	55418793	55418793	+	Silent	SNP	A	A	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:55418793A>T	ENST00000312422.2	+	1	414	c.414A>T	c.(412-414)acA>acT	p.T138T		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				ACCGGGAGACATGCAATAAAA	0.438000													96	59					0	0	0.014410	0	0
MC3R	4159	broad.mit.edu	37	20	54823932	54823932	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:54823932G>A	ENST00000243911.2	+	1	145	c.33G>A	c.(31-33)caG>caA	p.Q11Q		NM_019888.3	NP_063941.3	P41968	MC3R_HUMAN	melanocortin 3 receptor	48					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocyte-stimulating hormone receptor activity|neuropeptide binding|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(3)|skin(1)	26			Colorectal(105;0.202)			CCTCTGTTCAGCCAACACTGC	0.587000													81	168					0	0	0.014410	0	0
TP53	7157	broad.mit.edu	37	17	7577127	7577127	+	Missense_Mutation	SNP	C	C	T	rs67389650		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:7577127C>T	ENST00000420246.2	-	8	943	c.811G>A	c.(811-813)Gag>Aag	p.E271K	TP53_ENST00000455263.2_Missense_Mutation_p.E271K|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.E271K|TP53_ENST00000269305.4_Missense_Mutation_p.E271K|TP53_ENST00000445888.2_Missense_Mutation_p.E271K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	271	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> P (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> Q (in sporadic cancers; somatic mutation).|E -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> V (in an osteosarcoma with no family history; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E271K(28)|p.E271*(18)|p.0?(8)|p.E271Q(5)|p.?(2)|p.G266_E271delGRNSFE(2)|p.F270fs*72(1)|p.L265_K305del41(1)|p.E271P(1)|p.S269fs*21(1)|p.E258fs*71(1)|p.E271del(1)|p.S269fs*34(1)|p.F270_D281del12(1)|p.E271fs*34(1)|p.E271fs*35(1)|p.E271_R273delEVR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACGCACCTCAAAGCTGTTC	0.537000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			14	10					0	0	0.016723	0	0
ZNF716	441234	broad.mit.edu	37	7	57528802	57528802	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:57528802C>A	ENST00000420713.1	+	4	747	c.635C>A	c.(634-636)tCt>tAt	p.S212Y		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						AGGGAGAAGTCTTACAAATGT	0.358000													7	13					0.00198382	0.00211199	0.001984	1	0
IGSF11	152404	broad.mit.edu	37	3	118621435	118621435	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:118621435T>A	ENST00000354673.2	-	9	1605	c.1225A>T	c.(1225-1227)Aca>Tca	p.T409S	IGSF11_ENST00000425327.2_Missense_Mutation_p.T409S|IGSF11_ENST00000441144.2_Missense_Mutation_p.T385S|IGSF11_ENST00000491903.1_Missense_Mutation_p.T382S|IGSF11_ENST00000393775.2_Missense_Mutation_p.T410S|IGSF11_ENST00000489689.1_Missense_Mutation_p.T386S	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	410					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CGTTCCAGTGTTGCGTGGCTG	0.527000													38	70					0	0	0.006230	0	0
CSMD3	114788	broad.mit.edu	37	8	113318320	113318320	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:113318320G>T	ENST00000297405.5	-	51	8231	c.7987C>A	c.(7987-7989)Cga>Aga	p.R2663R	CSMD3_ENST00000352409.3_Silent_p.R2593R|CSMD3_ENST00000343508.3_Silent_p.R2623R|CSMD3_ENST00000455883.2_Silent_p.R2559R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2663	Sushi 15.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GATGACAATCGATATCCATCA	0.418000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			31	76					5.90632e-09	6.80394e-09	0.012213	1	0
BIRC8	112401	broad.mit.edu	37	19	53793115	53793115	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:53793115C>G	ENST00000426466.1	-	1	1760	c.513G>C	c.(511-513)caG>caC	p.Q171H		NM_033341.4	NP_203127.3	Q96P09	BIRC8_HUMAN	baculoviral IAP repeat containing 8	171					apoptosis		zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(10)|urinary_tract(1)	19				GBM - Glioblastoma multiforme(134;0.00304)		TGATTTCTCTCTGCAATGAAG	0.433000													23	48					0	0	0.012319	0	0
LPA	4018	broad.mit.edu	37	6	161071369	161071369	+	Splice_Site	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:161071369C>T	ENST00000447678.1	-	3	330		c.e3+1		LPA_ENST00000316300.5_Splice_Site	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)						blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	TAATGACATACGCATTTGGGT	0.403000													64	100					0	0	0.014410	0	0
SAMD9L	219285	broad.mit.edu	37	7	92763666	92763666	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:92763666C>A	ENST00000318238.4	-	5	2835	c.1619G>T	c.(1618-1620)aGa>aTa	p.R540I	SAMD9L_ENST00000437805.1_Missense_Mutation_p.R540I|SAMD9L_ENST00000411955.1_Missense_Mutation_p.R540I	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	540										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			AAATTTTCCTCTTGTCATTAT	0.368000													7	134					0.00198382	0.00211199	0.001984	1	0
ANKRD30A	91074	broad.mit.edu	37	10	37508673	37508673	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:37508673G>A	ENST00000374660.1	+	40	4321	c.4222G>A	c.(4222-4224)Gac>Aac	p.D1408N	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.D1289N|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.D1289N			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1345						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						TAAGAAAGCTGACAACAAAAG	0.318000													4	22					0	0	0.009096	0	0
SLITRK4	139065	broad.mit.edu	37	X	142716991	142716991	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:142716991C>T	ENST00000381779.4	-	2	2159	c.1934G>A	c.(1933-1935)cGc>cAc	p.R645H	SLITRK4_ENST00000356928.1_Missense_Mutation_p.R645H|SLITRK4_ENST00000338017.4_Missense_Mutation_p.R645H	NM_001184749.1|NM_001184750.1|NM_173078.3	NP_001171678.1|NP_001171679.1|NP_775101.1	Q8IW52	SLIK4_HUMAN	SLIT and NTRK-like family, member 4	645						integral to membrane				autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(27)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	60	Acute lymphoblastic leukemia(192;6.56e-05)					TTTCTTGTTGCGTCGCAGGAC	0.458000													25	61					0	0	0.018920	0	0
NUP210P1	255330	broad.mit.edu	37	3	126382195	126382195	+	RNA	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:126382195A>C	ENST00000357061.3	+	0	162					NR_034158.1																						GGCAGCCCCCAGCCTCAGTCC	0.602000													6	26					0	0	0.001984	0	0
TRPM6	140803	broad.mit.edu	37	9	77415379	77415379	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:77415379G>A	ENST00000451710.3	-	17	2266	c.2029C>T	c.(2029-2031)Ctg>Ttg	p.L677L	TRPM6_ENST00000376872.3_Intron|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376864.4_Silent_p.L677L|TRPM6_ENST00000449912.2_Silent_p.L672L|TRPM6_ENST00000360774.1_Silent_p.L677L|TRPM6_ENST00000361255.3_Silent_p.L672L			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	677					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						AACAAGTCCAGAGCCAGCTGG	0.458000													7	37					0	0	0.001984	0	0
UNC45A	55898	broad.mit.edu	37	15	91479540	91479540	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:91479540C>G	ENST00000394275.2	+	7	1066	c.231C>G	c.(229-231)gtC>gtG	p.V77V	UNC45A_ENST00000418476.2_Silent_p.V92V|UNC45A_ENST00000553671.2_3'UTR	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	92					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GTGGGGATGTCAAAGCACTCT	0.577000													42	69					0	0	0.014410	0	0
ZNF423	23090	broad.mit.edu	37	16	49672682	49672682	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:49672682G>A	ENST00000561648.1	-	4	434	c.381C>T	c.(379-381)ctC>ctT	p.L127L	ZNF423_ENST00000563137.2_Silent_p.L67L|ZNF423_ENST00000535559.1_Silent_p.L10L|ZNF423_ENST00000262383.2_Silent_p.L127L|ZNF423_ENST00000567169.1_Silent_p.L10L|ZNF423_ENST00000562520.1_Silent_p.L67L|ZNF423_ENST00000562871.1_Silent_p.L67L	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	127					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CCTCCTCGCCGAGGCCGAGGT	0.602000													28	15					0	0	0.005443	0	0
CFTR	1080	broad.mit.edu	37	7	117171025	117171025	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:117171025G>A	ENST00000003084.6	+	4	478	c.346G>A	c.(346-348)Gaa>Aaa	p.E116K	CFTR_ENST00000454343.1_Missense_Mutation_p.E116K	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	116	ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TAACAAGGAGGAACGCTCTAT	0.448000									Cystic Fibrosis				8	205					0	0	0.003080	0	0
PTPRO	5800	broad.mit.edu	37	12	15699627	15699627	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:15699627G>A	ENST00000281171.4	+	13	2619	c.2289G>A	c.(2287-2289)caG>caA	p.Q763Q	PTPRO_ENST00000348962.2_Silent_p.Q763Q|PTPRO_ENST00000442921.2_5'UTR|PTPRO_ENST00000542557.1_5'UTR|PTPRO_ENST00000544244.1_5'UTR|PTPRO_ENST00000445537.2_5'UTR	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	763	Fibronectin type-III 8.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				GCTCCAGTCAGAAAACCAAAC	0.393000													6	46					0	0	0.003080	0	0
AKAP9	10142	broad.mit.edu	37	7	91694636	91694636	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:91694636G>A	ENST00000359028.2	+	26	6330	c.6105G>A	c.(6103-6105)gtG>gtA	p.V2035V	AKAP9_ENST00000358100.2_Silent_p.V2035V|AKAP9_ENST00000356239.3_Silent_p.V2023V|AKAP9_ENST00000491695.1_3'UTR			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2035	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			AAAAACAAGTGAAAGCTCTAG	0.328000			T	BRAF	papillary thyroid								6	22					0	0	0.001168	0	0
C2orf48	348738	broad.mit.edu	37	2	10282472	10282472	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:10282472A>G	ENST00000381786.3	+	3	452	c.163A>G	c.(163-165)Agt>Ggt	p.S55G		NM_182626.2	NP_872432.1	Q96LS8	CB048_HUMAN	chromosome 2 open reading frame 48	55										endometrium(1)|lung(7)	8	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.188)		ggggtgcgccagtggaagcgg	0.592000													19	101					0	0	0.016522	0	0
SGCB	6443	broad.mit.edu	37	4	52890175	52890175	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:52890175C>A	ENST00000381431.5	-	6	1127	c.905G>T	c.(904-906)aGc>aTc	p.S302I	SGCB_ENST00000535450.1_Missense_Mutation_p.S232I	NM_000232.4	NP_000223.1	Q16585	SGCB_HUMAN	sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)	302	Cys-rich.				cytoskeleton organization|muscle organ development	cytoplasm|cytoskeleton|integral to plasma membrane|sarcoglycan complex|sarcolemma				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(6)|prostate(1)	17			GBM - Glioblastoma multiforme(4;7.63e-12)|LUSC - Lung squamous cell carcinoma(32;0.00204)			CATGTTCTGGCTGGTTACTTG	0.493000													18	34					1.56452e-12	1.85879e-12	0.007413	1	0
ZNF175	7728	broad.mit.edu	37	19	52090283	52090283	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:52090283C>T	ENST00000262259.2	+	5	1057	c.699C>T	c.(697-699)ttC>ttT	p.F233F	ZNF175_ENST00000436511.2_Intron	NM_007147.2	NP_009078.1	Q9Y473	ZN175_HUMAN	zinc finger protein 175	233					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	24		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		GTCAGCTATTCAGCCATAGCT	0.423000													18	33					0	0	0.007413	0	0
BAI1	575	broad.mit.edu	37	8	143603424	143603424	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:143603424G>T	ENST00000517894.1	+	21	4017	c.3123G>T	c.(3121-3123)acG>acT	p.T1041T	BAI1_ENST00000323289.5_Silent_p.T1041T			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1041					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TGGCGGTGACGGGCCACCTCC	0.667000													9	24					0.000673444	0.000727166	0.008291	1	0
PRSS3P2	154754	broad.mit.edu	37	7	142482242	142482242	+	RNA	SNP	G	G	A	rs143538588	by1000genomes	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:142482242G>A	ENST00000603901.1	+	0	622					NR_001296.3																						GGTCTGCAATGGACAGCTTCA	0.493000													4	42					0	0	0.014758	0	0
PRDM9	56979	broad.mit.edu	37	5	23524634	23524634	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:23524634G>A	ENST00000296682.3	+	10	1324	c.1142G>A	c.(1141-1143)aGa>aAa	p.R381K		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	381				Missing (in Ref. 4; AAF87242).	meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						ATGGCAGGGAGAGGTAGGCAT	0.448000										HNSCC(3;0.000094)			15	50					0	0	0.016522	0	0
PLEKHA8P1	51054	broad.mit.edu	37	12	45567729	45567729	+	RNA	SNP	A	A	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:45567729A>C	ENST00000256692.5	-	0	956					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TATTTTCCTCACTTGATATGC	0.318000													6	37					0	0	0.001168	0	0
ZNF544	27300	broad.mit.edu	37	19	58773169	58773169	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:58773169G>C	ENST00000269829.4	+	7	1671	c.1197G>C	c.(1195-1197)caG>caC	p.Q399H	CTD-3138B18.4_ENST00000600029.1_Intron|ZNF544_ENST00000595981.1_Intron|ZNF544_ENST00000600044.1_Missense_Mutation_p.Q371H|ZNF544_ENST00000596929.1_Intron|ZNF544_ENST00000596825.1_3'UTR|ZNF544_ENST00000415203.2_Missense_Mutation_p.Q371H|ZNF544_ENST00000599953.1_Missense_Mutation_p.Q257H|ZNF544_ENST00000600220.1_Missense_Mutation_p.Q371H|CTD-3138B18.5_ENST00000597230.1_RNA|ZNF544_ENST00000596652.1_Missense_Mutation_p.Q399H|ZNF544_ENST00000599227.1_3'UTR	NM_014480.2	NP_055295.2	Q6NX49	ZN544_HUMAN	zinc finger protein 544	399					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)|urinary_tract(1)	18		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		TCATACATCAGAGGACACACA	0.463000													9	53					0	0	0.006214	0	0
ZFP14	57677	broad.mit.edu	37	19	36831959	36831959	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:36831959C>T	ENST00000270001.7	-	5	884	c.769G>A	c.(769-771)Gaa>Aaa	p.E257K		NM_020917.2	NP_065968.1	Q9HCL3	ZFP14_HUMAN	ZFP14 zinc finger protein	257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	26	Esophageal squamous(110;0.162)					TCCTTACATTCATAGGGTTTT	0.448000													57	26					0	0	0.014410	0	0
EYA4	2070	broad.mit.edu	37	6	133777745	133777745	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:133777745C>A	ENST00000367895.5	+	6	793	c.329C>A	c.(328-330)gCc>gAc	p.A110D	EYA4_ENST00000431403.2_Missense_Mutation_p.A110D|EYA4_ENST00000430974.2_Intron|EYA4_ENST00000355167.3_Missense_Mutation_p.A110D|EYA4_ENST00000531901.1_Missense_Mutation_p.A110D|EYA4_ENST00000355286.6_Missense_Mutation_p.A87D|EYA4_ENST00000525849.1_Missense_Mutation_p.A87D|EYA4_ENST00000452339.2_Intron	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	110					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity	p.A110V(2)		breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		GAAACCACAGCCACGACTGGA	0.458000													12	135					1.52009e-12	1.81168e-12	0.003163	1	0
SLC52A2	79581	broad.mit.edu	37	8	145583767	145583767	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:145583767C>T	ENST00000532887.1	+	3	1198	c.615C>T	c.(613-615)gtC>gtT	p.V205V	SLC52A2_ENST00000527078.1_Silent_p.V205V|SLC52A2_ENST00000526752.1_Intron|SLC52A2_ENST00000530047.1_Silent_p.V205V|SLC52A2_ENST00000540505.1_Silent_p.V117V|SLC52A2_ENST00000402965.1_Silent_p.V205V|SLC52A2_ENST00000329994.2_Silent_p.V205V			Q9HAB3	RFT3_HUMAN	solute carrier family 52 (riboflavin transporter), member 2	205						integral to plasma membrane	receptor activity|riboflavin transporter activity										CCCTTCTGGTCGCTTCAGCTG	0.652000													15	84					0	0	0.004007	0	0
ISLR2	57611	broad.mit.edu	37	15	74425518	74425518	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:74425518C>T	ENST00000361742.3	+	4	1192	c.423C>T	c.(421-423)gaC>gaT	p.D141D	ISLR2_ENST00000453268.2_Silent_p.D141D|ISLR2_ENST00000435464.1_Silent_p.D141D|ISLR2_ENST00000565540.1_Silent_p.D141D|ISLR2_ENST00000565159.1_Silent_p.D141D|ISLR2_ENST00000561975.1_Intron|ISLR2_ENST00000419208.1_Silent_p.D141D|ISLR2_ENST00000445793.1_Silent_p.D141D	NM_001130136.1|NM_020851.2	NP_001123608.1|NP_065902.1	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing leucine-rich repeat 2	141					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane				breast(3)|endometrium(6)|large_intestine(7)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	36						TGCCCCGGGACGCACTCGGTG	0.637000													10	104					0	0	0.006214	0	0
ZNF292	23036	broad.mit.edu	37	6	87966229	87966229	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr6:87966229G>A	ENST00000369577.3	+	8	2925	c.2882G>A	c.(2881-2883)gGc>gAc	p.G961D	ZNF292_ENST00000339907.4_Missense_Mutation_p.G956D	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	961					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ACTGTGGAAGGCAGTGGTGAA	0.433000													20	47					0	0	0.010504	0	0
EIF4G3	8672	broad.mit.edu	37	1	21276584	21276584	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:21276584G>A	ENST00000602326.1	-	11	1168	c.585C>T	c.(583-585)ccC>ccT	p.P195P	EIF4G3_ENST00000536266.1_Intron|EIF4G3_ENST00000264211.8_Silent_p.P189P|EIF4G3_ENST00000400422.1_Silent_p.P189P|EIF4G3_ENST00000374935.3_Silent_p.P189P|EIF4G3_ENST00000374927.4_Silent_p.P189P|EIF4G3_ENST00000374937.3_Silent_p.P195P|EIF4G3_ENST00000356916.3_Silent_p.P200P	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	189					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GGCTGTGCTCGGGGACCTGGC	0.527000													10	31					0	0	0.013537	0	0
OR4P4	81300	broad.mit.edu	37	11	55406751	55406751	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:55406751G>A	ENST00000314612.2	+	1	918	c.918G>A	c.(916-918)ctG>ctA	p.L306L		NM_001004124.1	NP_001004124.1	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P, member 4	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L306L(1)		autonomic_ganglia(1)|central_nervous_system(1)|kidney(4)|large_intestine(4)|lung(28)|ovary(1)|upper_aerodigestive_tract(1)	40						AAATACTCCTGAAAAGAAATC	0.398000													8	24					0	0	0.003080	0	0
NLRP7	199713	broad.mit.edu	37	19	55452960	55452960	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:55452960C>T	ENST00000588756.1	-	4	606	c.120G>A	c.(118-120)aaG>aaA	p.K40K	NLRP7_ENST00000328092.5_Silent_p.K40K|NLRP7_ENST00000592784.1_Silent_p.K40K|NLRP7_ENST00000448121.2_Silent_p.K40K|NLRP7_ENST00000340844.2_Silent_p.K40K|NLRP7_ENST00000446217.1_Silent_p.K68K|NLRP7_ENST00000590030.1_Silent_p.K40K			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	40	DAPIN.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		ACCATGGGGTCTTCTGTAGCA	0.478000													25	56					0	0	0.018920	0	0
CTIF	9811	broad.mit.edu	37	18	46343675	46343675	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:46343675C>T	ENST00000256413.3	+	10	1750	c.1455C>T	c.(1453-1455)ttC>ttT	p.F485F	CTIF_ENST00000382998.4_Silent_p.F487F	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	485	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						GCGAGGTCTTCGGCACCATGC	0.647000													12	48					0	0	0.013537	0	0
THRA	7067	broad.mit.edu	37	17	38243028	38243028	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:38243028C>T	ENST00000450525.2	+	7	1136	c.645C>T	c.(643-645)ttC>ttT	p.F215F	THRA_ENST00000394121.4_Silent_p.F215F|THRA_ENST00000264637.4_Silent_p.F215F|THRA_ENST00000546243.1_Silent_p.F215F|THRA_ENST00000584985.1_Silent_p.F215F	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha	215	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	TGGAAGCCTTCAGCGAGTTTA	0.582000											OREG0024390	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	142					0	0	0.006214	0	0
DONSON	29980	broad.mit.edu	37	21	34951771	34951771	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:34951771G>A	ENST00000303071.5	-	9	1514	c.1448C>T	c.(1447-1449)tCa>tTa	p.S483L	DONSON_ENST00000453626.1_Intron|DONSON_ENST00000432378.1_Intron|DONSON_ENST00000303113.6_Missense_Mutation_p.S469L	NM_017613.3	NP_060083.1	Q9NYP3	DONS_HUMAN	downstream neighbor of SON	483					multicellular organismal development	nucleus				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|ovary(1)	11						CATGGTCAGTGAATGCAGAGA	0.448000													7	39					0	0	0.001984	0	0
CYP2C19	1557	broad.mit.edu	37	10	96534866	96534866	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:96534866A>G	ENST00000371321.3	+	2	302	c.220A>G	c.(220-222)Atg>Gtg	p.M74V	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	74			M -> T (in dbSNP:rs28399505).		exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	CCTGGAACGCATGGTGGTGCT	0.453000													52	28					0	0	0.014410	0	0
DNHD1	144132	broad.mit.edu	37	11	6523987	6523987	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:6523987C>G	ENST00000254579.6	+	4	1315	c.751C>G	c.(751-753)Cag>Gag	p.Q251E	DNHD1_ENST00000354685.3_Missense_Mutation_p.Q251E|DNHD1_ENST00000527990.2_Missense_Mutation_p.Q251E	NM_144666.2	NP_653267.2	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1	251					microtubule-based movement	dynein complex	microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(13)|kidney(6)|large_intestine(11)|lung(14)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	55		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		ACACAGGTCTCAGCTTGACTA	0.493000													13	15					0	0	0.013537	0	0
REG1P	5969	broad.mit.edu	37	2	79363278	79363278	+	RNA	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:79363278C>G	ENST00000444841.1	-	0	1060																											TGTTCGCACTCAGAAACAGGT	0.433000													7	8					0	0	0.001984	0	0
CEP76	79959	broad.mit.edu	37	18	12686344	12686344	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:12686344C>G	ENST00000262127.2	-	8	1264	c.1039G>C	c.(1039-1041)Ggt>Cgt	p.G347R	RP11-973H7.2_ENST00000585331.1_RNA|CEP76_ENST00000423709.2_Missense_Mutation_p.G272R	NM_024899.2	NP_079175.2	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	347					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(7)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CGTTCATAACCAAGGACATTA	0.443000													9	20					0	0	0.006214	0	0
PROS1	5627	broad.mit.edu	37	3	93615521	93615521	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:93615521G>A	ENST00000394236.3	-	9	1180	c.864C>T	c.(862-864)tgC>tgT	p.C288C	PROS1_ENST00000407433.1_Silent_p.C157C	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	288					leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TCAAGGGAAGGCACACTGAAA	0.358000													40	97					0	0	0.006230	0	0
SPEN	23013	broad.mit.edu	37	1	16258058	16258058	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:16258058G>A	ENST00000375759.3	+	11	5527	c.5323G>A	c.(5323-5325)Gaa>Aaa	p.E1775K		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1775					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCCAAAGGCCGAAAAGCCAGA	0.532000													21	90					0	0	0.008871	0	0
CSMD3	114788	broad.mit.edu	37	8	113299453	113299453	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:113299453G>A	ENST00000297405.5	-	58	9415	c.9171C>T	c.(9169-9171)ggC>ggT	p.G3057G	CSMD3_ENST00000352409.3_Silent_p.G2987G|CSMD3_ENST00000343508.3_Silent_p.G3017G|CSMD3_ENST00000455883.2_Silent_p.G2888G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3057	Sushi 22.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TACCTGGATCGCCACATGTCC	0.438000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	135					0	0	0.002450	0	0
KIAA0195	9772	broad.mit.edu	37	17	73485368	73485368	+	Silent	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:73485368G>T	ENST00000314256.7	+	8	1180	c.786G>T	c.(784-786)ctG>ctT	p.L262L	KIAA0195_ENST00000583795.1_3'UTR|KIAA0195_ENST00000375248.5_Silent_p.L272L|KIAA0195_ENST00000579208.1_Intron	NM_014738.4	NP_055553.3	Q12767	K0195_HUMAN	KIAA0195	262					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			breast(2)|endometrium(5)|kidney(2)|large_intestine(7)|lung(17)|ovary(5)|skin(2)|stomach(1)|urinary_tract(1)	42	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACATGGCCCTGTCCCGACCAG	0.582000													10	29					4.68919e-08	5.36919e-08	0.008291	1	0
LPHN3	23284	broad.mit.edu	37	4	62758580	62758580	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:62758580G>A	ENST00000512091.1	+	9	2230	c.1483G>A	c.(1483-1485)Gaa>Aaa	p.E495K	LPHN3_ENST00000507164.1_Missense_Mutation_p.E563K|LPHN3_ENST00000545650.1_Missense_Mutation_p.E495K|LPHN3_ENST00000514157.1_Missense_Mutation_p.E495K|LPHN3_ENST00000508693.1_Missense_Mutation_p.E563K|LPHN3_ENST00000506720.1_Missense_Mutation_p.E563K|LPHN3_ENST00000504896.1_Missense_Mutation_p.E495K|LPHN3_ENST00000506700.1_Missense_Mutation_p.E495K|LPHN3_ENST00000509896.1_Missense_Mutation_p.E563K|LPHN3_ENST00000508946.1_Missense_Mutation_p.E495K|LPHN3_ENST00000506746.1_Missense_Mutation_p.E563K|LPHN3_ENST00000511324.1_Missense_Mutation_p.E563K|LPHN3_ENST00000514996.1_Missense_Mutation_p.E495K|LPHN3_ENST00000507625.1_Missense_Mutation_p.E563K|LPHN3_ENST00000514591.1_Missense_Mutation_p.E495K			Q9HAR2	LPHN3_HUMAN	latrophilin 3	495					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						CCCAGCTCTCGAAGAGAGCTG	0.502000													5	19					0	0	0.001168	0	0
WDR45	11152	broad.mit.edu	37	X	48933333	48933333	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:48933333G>A	ENST00000356463.3	-	9	1037	c.599C>T	c.(598-600)tCt>tTt	p.S200F	WDR45_ENST00000553851.1_Missense_Mutation_p.S97F|WDR45_ENST00000470270.1_5'UTR|WDR45_ENST00000396681.4_Missense_Mutation_p.S199F|WDR45_ENST00000376372.3_Missense_Mutation_p.S199F|WDR45_ENST00000322995.8_Missense_Mutation_p.S210F|WDR45_ENST00000376368.2_Missense_Mutation_p.S200F|WDR45_ENST00000376358.3_Missense_Mutation_p.S97F|WDR45_ENST00000485908.1_Missense_Mutation_p.S164F|WDR45_ENST00000473974.1_Missense_Mutation_p.S199F	NM_007075.3	NP_009006.2	Q9Y484	WIPI4_HUMAN	WD repeat domain 45	199					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	19						CTGGTTTAGAGACACACAGGC	0.562000													7	3					0	0	0.001984	0	0
FAM210A	125228	broad.mit.edu	37	18	13682015	13682015	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:13682015T>C	ENST00000322247.3	-	3	449	c.62A>G	c.(61-63)cAt>cGt	p.H21R	FAM210A_ENST00000402563.1_Missense_Mutation_p.H21R|FAM210A_ENST00000588475.1_5'UTR	NM_001098801.1	NP_001092271.1	Q96ND0	CR019_HUMAN	family with sequence similarity 210, member A	21						integral to membrane											ACCAGCATTATGTGGTTCCAA	0.418000													16	49					0	0	0.004990	0	0
UBE2C	11065	broad.mit.edu	37	20	44444383	44444383	+	Splice_Site	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:44444383A>G	ENST00000405520.1	+	3	1140	c.304_splice	c.e3+1	p.G101_splice	UBE2C_ENST00000352551.5_Splice_Site_p.G111_splice|UBE2C_ENST00000356455.4_Splice_Site_p.G140_splice|UBE2C_ENST00000335046.3_Intron|UBE2C_ENST00000243893.6_Intron|UBE2C_ENST00000372568.4_Splice_Site_p.G101_splice|UBE2C_ENST00000496085.1_3'UTR	NM_181802.1	NP_861518.1	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C	140					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(2)|lung(2)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				GCCTTCTAGGAGGTGACTTTA	0.542000													13	83					0	0	0.013537	0	0
AE000661.37	0	broad.mit.edu	37	14	22891846	22891846	+	RNA	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:22891846A>G	ENST00000514473.2	-	0	225				AE000661.37_ENST00000545670.1_RNA|AE000661.37_ENST00000535351.1_RNA|AE000661.37_ENST00000537850.1_RNA|AE000661.37_ENST00000541008.1_RNA|TRDV2_ENST00000390469.2_RNA																							GGTAACTACTATATCAACTGG	0.478000													45	25					0	0	0.013114	0	0
BIRC6	57448	broad.mit.edu	37	2	32800426	32800426	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:32800426C>T	ENST00000421745.2	+	66	13482	c.13348C>T	c.(13348-13350)Cgt>Tgt	p.R4450C		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4450					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CTATACCAACCGTTTAAGGTA	0.358000													43	26					0	0	0.008740	0	0
PRCP	5547	broad.mit.edu	37	11	82536054	82536054	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:82536054T>C	ENST00000313010.3	-	9	1579	c.1385A>G	c.(1384-1386)aAg>aGg	p.K462R	PRCP_ENST00000535099.1_Missense_Mutation_p.K357R|PRCP_ENST00000525772.1_5'UTR|PRCP_ENST00000393399.2_Missense_Mutation_p.K483R	NM_005040.2	NP_005031.1	P42785	PCP_HUMAN	prolylcarboxypeptidase (angiotensinase C)	462					blood coagulation, intrinsic pathway|proteolysis	lysosome|plasma membrane	protein binding|serine-type carboxypeptidase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)|urinary_tract(1)	17						CAAGGCATTCTTGGTGCGGAG	0.502000													17	39					0	0	0.006122	0	0
ASB4	51666	broad.mit.edu	37	7	95125216	95125216	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:95125216C>A	ENST00000325885.5	+	2	405	c.334C>A	c.(334-336)Cac>Aac	p.H112N	ASB4_ENST00000257621.4_3'UTR|ASB4_ENST00000428113.1_Missense_Mutation_p.H112N	NM_016116.2	NP_057200.1	Q9Y574	ASB4_HUMAN	ankyrin repeat and SOCS box containing 4	112					intracellular signal transduction					central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(8)|pancreas(1)|prostate(1)|skin(2)	20	all_cancers(62;2.27e-10)|all_epithelial(64;2.28e-09)|Lung NSC(181;0.218)|all_lung(186;0.246)		STAD - Stomach adenocarcinoma(171;0.0151)			AACCCCTCTTCACGTGGCTTG	0.478000													24	201					3.28513e-13	3.95258e-13	0.003954	1	0
MLH1	4292	broad.mit.edu	37	3	37053345	37053345	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:37053345G>A	ENST00000231790.2	+	7	796	c.580G>A	c.(580-582)Gtt>Att	p.V194I	MLH1_ENST00000455445.2_5'UTR|MLH1_ENST00000539477.1_5'UTR|MLH1_ENST00000435176.1_Missense_Mutation_p.V96I|MLH1_ENST00000536378.1_5'UTR|MLH1_ENST00000458205.2_5'UTR	NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	194					mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						TAGTTTCTCAGTTAAAAAAGT	0.353000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				27	121					0	0	0.008361	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74540470	74540470	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:74540470A>G	ENST00000354431.4	-	6	1063	c.872T>C	c.(871-873)aTa>aCa	p.I291T	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.I291T	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	291										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						AGGATAATATATATTCTGTGA	0.264000													3	9					0	0	0.009096	0	0
TM9SF4	9777	broad.mit.edu	37	20	30720911	30720911	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr20:30720911C>T	ENST00000217315.5	+	2	400	c.60C>T	c.(58-60)aaC>aaT	p.N20N	TM9SF4_ENST00000398022.2_Silent_p.N37N			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	37						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			TCCACCAGAACGATCCCGTAG	0.517000													5	56					0	0	0.014758	0	0
THRB	7068	broad.mit.edu	37	3	24174828	24174828	+	Silent	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:24174828T>C	ENST00000396671.2	-	9	1212	c.864A>G	c.(862-864)aaA>aaG	p.K288K	THRB_ENST00000416420.1_Silent_p.K288K|THRB_ENST00000280696.5_Silent_p.K303K|THRB_ENST00000356447.4_Silent_p.K288K	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	288	Interaction with NR2F6.|Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	TAGGCAACTTTTTGGCAAAAT	0.383000													4	28					0	0	0.009096	0	0
OR4K14	122740	broad.mit.edu	37	14	20482822	20482822	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr14:20482822G>A	ENST00000305045.2	-	1	530	c.531C>T	c.(529-531)agC>agT	p.S177S		NM_001004712.1	NP_001004712.1	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K, member 14	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(20)|skin(6)	37	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CACAGAAGAAGCTGTCTACCT	0.488000													14	33					0	0	0.003163	0	0
PRAMEF2	65122	broad.mit.edu	37	1	12919947	12919947	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:12919947G>A	ENST00000240189.2	+	3	774	c.687G>A	c.(685-687)aaG>aaA	p.K229K		NM_023014.1	NP_075390.1	O60811	PRAM2_HUMAN	PRAME family member 2	229								p.K229K(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(22)|prostate(6)|skin(3)|upper_aerodigestive_tract(4)	42	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;2.4e-06)|Kidney(185;4.89e-05)|COAD - Colon adenocarcinoma(227;0.000152)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTTACCTGAAGGAGATGAAGA	0.403000													15	97					0	0	0.004007	0	0
PABPC5	140886	broad.mit.edu	37	X	90691232	90691232	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:90691232T>C	ENST00000312600.3	+	2	870	c.656T>C	c.(655-657)tTc>tCc	p.F219S	PABPC5_ENST00000373105.1_Missense_Mutation_p.F55S	NM_080832.2	NP_543022.1	Q96DU9	PABP5_HUMAN	poly(A) binding protein, cytoplasmic 5	219	RRM 3.					cytoplasm	nucleotide binding|RNA binding			central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(20)|ovary(1)|pancreas(1)	42						AAGGAACTTTTCTGTGAATAT	0.438000													15	14					0	0	0.002450	0	0
TG	7038	broad.mit.edu	37	8	133883613	133883613	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:133883613C>A	ENST00000220616.4	+	4	335	c.295C>A	c.(295-297)Cag>Aag	p.Q99K	TG_ENST00000377869.1_Missense_Mutation_p.Q99K	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	99	Thyroglobulin type-1 2.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TTGTCAGCTACAGAAACAGCA	0.502000													20	227					1.64113e-05	1.82402e-05	0.010504	1	0
C2orf78	388960	broad.mit.edu	37	2	74042383	74042383	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:74042383C>T	ENST00000409561.1	+	3	1154	c.1033C>T	c.(1033-1035)Ctc>Ttc	p.L345F		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	345										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TCCTACTAATCTCTTGACACT	0.438000													26	32					0	0	0.018920	0	0
TTN	7273	broad.mit.edu	37	2	179452360	179452360	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:179452360C>G	ENST00000589042.1	-	306	63900	c.63676G>C	c.(63676-63678)Gac>Cac	p.D21226H	TTN_ENST00000460472.2_Missense_Mutation_p.D12161H|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D12286H|TTN_ENST00000342992.6_Missense_Mutation_p.D18658H|TTN_ENST00000342175.6_Missense_Mutation_p.D12353H|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000590743.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D19585H|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	19585	Fibronectin type-III 54.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCATAGTGTCAACCAGATCA	0.453000													8	40					0	0	0.004482	0	0
PAX2	5076	broad.mit.edu	37	10	102546746	102546746	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:102546746G>C	ENST00000370296.2	+	6	1213	c.663G>C	c.(661-663)ttG>ttC	p.L221F	PAX2_ENST00000355243.3_Intron|PAX2_ENST00000556085.1_Intron|PAX2_ENST00000361791.3_Intron|PAX2_ENST00000428433.1_Missense_Mutation_p.L221F|PAX2_ENST00000553492.1_Intron			Q02962	PAX2_HUMAN	paired box 2	221					anti-apoptosis|axonogenesis|brain morphogenesis|branching involved in ureteric bud morphogenesis|cell fate determination|cellular response to glucose stimulus|cellular response to hydrogen peroxide|cellular response to retinoic acid|cochlea development|glial cell differentiation|inner ear morphogenesis|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesodermal cell fate specification|mesonephros development|metanephric collecting duct development|metanephric distal convoluted tubule development|metanephric mesenchymal cell differentiation|metanephric nephron tubule formation|negative regulation of caspase activity|negative regulation of cytolysis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|negative regulation of reactive oxygen species metabolic process|negative regulation of transcription, DNA-dependent|nephric duct formation|neural tube closure|optic chiasma development|optic cup morphogenesis involved in camera-type eye development|optic nerve structural organization|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of epithelial cell proliferation|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of metanephric glomerulus development|positive regulation of optic nerve formation|positive regulation of transcription from RNA polymerase II promoter|pronephric field specification|protein kinase B signaling cascade|reactive oxygen species metabolic process|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of metanephros size|retinal pigment epithelium development|stem cell differentiation|transcription from RNA polymerase II promoter|ureter maturation|vestibulocochlear nerve formation|visual perception	centriolar satellite|nucleus|protein complex|protein-DNA complex	core promoter proximal region sequence-specific DNA binding|superoxide-generating NADPH oxidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	18		Colorectal(252;0.234)		Epithelial(162;1.32e-08)|all cancers(201;7.32e-07)		GTGGAGGTTTGCATCTGGTCT	0.512000											OREG0002760	type=REGULATORY REGION|Gene=PAX2(intragenic)|Dataset=Vista Enhancers|EvidenceSubtype=In-vivo LacZ Expression Assay	16	17					0	0	0.004007	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443687	5443687	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:5443687T>G	ENST00000300778.4	+	1	347	c.257T>G	c.(256-258)cTt>cGt	p.L86R	HBG2_ENST00000380252.1_Intron|AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTCATGCAGCTTCTCTGGTTC	0.522000													14	62					0	0	0.002450	0	0
CCDC148	130940	broad.mit.edu	37	2	159196885	159196885	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:159196885G>C	ENST00000283233.5	-	5	668	c.355C>G	c.(355-357)Cag>Gag	p.Q119E	CCDC148_ENST00000409187.1_Missense_Mutation_p.Q128E|CCDC148_ENST00000536771.1_Missense_Mutation_p.Q33E|CCDC148_ENST00000409889.1_Missense_Mutation_p.Q119E	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	119										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TATGTGCACTGTTGTTCTGAT	0.338000													3	42					0	0	0.004672	0	0
LHX6	26468	broad.mit.edu	37	9	124989209	124989209	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:124989209G>A	ENST00000394319.4	-	3	361	c.257C>T	c.(256-258)tCt>tTt	p.S86F	LHX6_ENST00000373754.2_Missense_Mutation_p.S57F|LHX6_ENST00000541397.2_Missense_Mutation_p.S75F|LHX6_ENST00000340587.3_Missense_Mutation_p.S86F|LHX6_ENST00000373755.2_Missense_Mutation_p.S57F	NM_014368.4	NP_055183.2	Q9UPM6	LHX6_HUMAN	LIM homeobox 6	57	LIM zinc-binding 1.|Required for interaction with LBD1 (By similarity).				cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)	8						GGAGGCGGCAGAGGGCGGTGA	0.647000													5	1					0	0	0.014758	0	0
LPPR4	9890	broad.mit.edu	37	1	99771339	99771339	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:99771339C>A	ENST00000370185.3	+	7	1562	c.1065C>A	c.(1063-1065)aaC>aaA	p.N355K	LPPR4_ENST00000457765.1_Missense_Mutation_p.N297K|LPPR4_ENST00000370184.1_Missense_Mutation_p.N197K	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		355							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		AAGATCCCAACCGACTTTTAT	0.478000													16	81					1.5739e-10	1.84677e-10	0.004007	1	0
C12orf45	121053	broad.mit.edu	37	12	105380132	105380132	+	Translation_Start_Site	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:105380132T>C	ENST00000552951.1	+	1	45	c.2T>C	c.(1-3)aTg>aCg	p.M1T	C12orf45_ENST00000280749.5_Start_Codon_SNP_p.M1T	NM_152318.2	NP_689531.2	Q8N5I9	CL045_HUMAN	chromosome 12 open reading frame 45	1										large_intestine(1)|lung(2)	3						GAGGGAAGCATGGAGGTCCAT	0.652000													5	7					0	0	0.014758	0	0
NDUFB4	4710	broad.mit.edu	37	3	120320118	120320118	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:120320118C>T	ENST00000485064.1	+	2	373	c.341C>T	c.(340-342)aCc>aTc	p.T114I	NDUFB4_ENST00000184266.2_Intron|NDUFB4_ENST00000492739.1_Intron	NM_001168331.1	NP_001161803.1	O95168	NDUB4_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa	0					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(1)|large_intestine(1)|lung(3)	5				GBM - Glioblastoma multiforme(114;0.14)	NADH(DB00157)	AGTATTCAGACCAGATGTTTA	0.463000													18	131					0	0	0.006122	0	0
PTER	9317	broad.mit.edu	37	10	16547037	16547037	+	Silent	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:16547037A>G	ENST00000378000.1	+	5	963	c.717A>G	c.(715-717)aaA>aaG	p.K239K	PTER_ENST00000298942.3_Silent_p.K239K|PTER_ENST00000423462.2_Intron|PTER_ENST00000535784.2_Silent_p.K239K	NM_001001484.2|NM_001261838.1|NM_030664.4	NP_001001484.1|NP_001248767.1|NP_109589.2	Q96BW5	PTER_HUMAN	phosphotriesterase related	239					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(2)	15						TTGATAAGAAAGAGCTCTTGG	0.393000													25	71					0	0	0.004656	0	0
HMGCS1	3157	broad.mit.edu	37	5	43299040	43299040	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:43299040C>T	ENST00000325110.6	-	3	234	c.28G>A	c.(28-30)Gaa>Aaa	p.E10K	HMGCS1_ENST00000433297.2_Missense_Mutation_p.E10K	NM_001098272.2	NP_001091742.1	Q01581	HMCS1_HUMAN	3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)	10					cholesterol biosynthetic process|isoprenoid biosynthetic process	cytosol|soluble fraction	hydroxymethylglutaryl-CoA synthase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|stomach(1)|urinary_tract(1)	15						CAGCAAGCTTCTGCATTCAAA	0.373000													12	50					0	0	0.013537	0	0
ZSCAN1	284312	broad.mit.edu	37	19	58565065	58565065	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:58565065C>T	ENST00000282326.1	+	6	1120	c.873C>T	c.(871-873)ccC>ccT	p.P291P		NM_182572.3	NP_872378.3	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	291					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GTGGGCGGCCCTTCCAGTGTG	0.652000													6	65					0	0	0.001984	0	0
GAB4	128954	broad.mit.edu	37	22	17472947	17472947	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:17472947G>A	ENST00000400588.1	-	2	401	c.294C>T	c.(292-294)ctC>ctT	p.L98L	GAB4_ENST00000523144.1_5'UTR	NM_001037814.1	NP_001032903.1	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member 4	98	PH.									breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(24)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GCTGCTCACAGAGGTTCAGGT	0.488000													86	166					0	0	0.014410	0	0
CHUK	1147	broad.mit.edu	37	10	101960516	101960516	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:101960516C>A	ENST00000370397.7	-	15	1677	c.1591G>T	c.(1591-1593)Gag>Tag	p.E531*		NM_001278.3	NP_001269.3	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	531					I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(9)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)	27		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		ATCTGATCCTCCAGGTATCCA	0.398000													7	51					1.26484e-09	1.475e-09	0.003080	1	0
TBL1X	6907	broad.mit.edu	37	X	9679741	9679741	+	Silent	SNP	C	C	T	rs139999402		TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:9679741C>T	ENST00000217964.7	+	16	2170	c.1530C>T	c.(1528-1530)agC>agT	p.S510S	TBL1X_ENST00000536365.1_Silent_p.S459S|TBL1X_ENST00000407597.2_Silent_p.S510S|TBL1X_ENST00000380961.1_Silent_p.S459S|TBL1X_ENST00000424279.1_Silent_p.S459S	NM_005647.3	NP_005638.1	O60907	TBL1X_HUMAN	transducin (beta)-like 1X-linked	510					canonical Wnt receptor signaling pathway|cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|sensory perception of sound|transcription, DNA-dependent	spindle microtubule|transcriptional repressor complex	beta-catenin binding|histone binding|protein C-terminus binding|protein domain specific binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(7)|lung(2)|ovary(1)|skin(2)	20		Hepatocellular(5;0.000888)				CTGTCTATAGCGTAGCTTTCA	0.532000													25	8					0	0	0.016522	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072541	17072541	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr22:17072541G>A	ENST00000359963.3	-	1	1159	c.900C>T	c.(898-900)gaC>gaT	p.D300D		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	300					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				GGGTCTCCTCGTCGACCTCCC	0.493000													65	157					0	0	0.014410	0	0
HECW1	23072	broad.mit.edu	37	7	43506115	43506115	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:43506115C>T	ENST00000395891.1	+	15	3466	c.2861C>T	c.(2860-2862)gCg>gTg	p.A954V	HECW1_ENST00000453890.1_Missense_Mutation_p.A920V	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	954					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CAGTCCCCAGCGGTCAAGTTC	0.498000													29	55					0	0	0.007291	0	0
TMEM132D	121256	broad.mit.edu	37	12	129563160	129563160	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:129563160G>A	ENST00000422113.2	-	8	2360	c.2034C>T	c.(2032-2034)ctC>ctT	p.L678L	TMEM132D_ENST00000389441.4_Silent_p.L216L	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	678						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GCTGCAAGGAGAGTGACAGCC	0.572000													13	60					0	0	0.016723	0	0
PRSS3P2	154754	broad.mit.edu	37	7	142482229	142482229	+	RNA	SNP	T	T	A	rs145494190	by1000genomes	TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:142482229T>A	ENST00000603901.1	+	0	609					NR_001296.3													p.P203P(1)									CTGGTGGCCCTGTGGTCTGCA	0.493000													4	41					0	0	0.014758	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187703872	187703872	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:187703872T>C	ENST00000295131.2	-	4	347	c.308A>G	c.(307-309)gAa>gGa	p.E103G		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	103					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			TATCTCTCTTTCTCCAAGACC	0.403000													64	139					0	0	0.014410	0	0
RTP1	132112	broad.mit.edu	37	3	186917551	186917551	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:186917551G>T	ENST00000312295.4	+	2	515	c.485G>T	c.(484-486)cGc>cTc	p.R162L	RP11-208N14.4_ENST00000356133.3_RNA	NM_153708.2	NP_714919.2	P59025	RTP1_HUMAN	receptor (chemosensory) transporter protein 1	162					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			breast(2)|endometrium(4)|large_intestine(5)|lung(6)|ovary(3)|skin(2)	22	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		ACCAGCCTGCGCGAGCAGTGC	0.677000													25	12					6.07407e-21	7.57261e-21	0.007291	1	0
HCN4	10021	broad.mit.edu	37	15	73614946	73614946	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:73614946G>T	ENST00000261917.3	-	8	4481	c.3488C>A	c.(3487-3489)cCc>cAc	p.P1163H		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	1163					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		AGACAGAGGGGGTGGCAAAGA	0.677000													11	10					2.80697e-09	3.26332e-09	0.010729	1	0
KRTAP1-1	81851	broad.mit.edu	37	17	39197549	39197549	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:39197549G>C	ENST00000306271.4	-	1	164	c.101C>G	c.(100-102)tCc>tGc	p.S34C		NM_030967.2	NP_112229.1	Q07627	KRA11_HUMAN	keratin associated protein 1-1	34			Missing (in allele KAP1.7).|PSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQT SFCGFP -> R (in allele KAP1.6).			extracellular region|keratin filament		p.S34C(6)		NS(2)|endometrium(2)|kidney(5)|lung(4)|prostate(1)	14		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			TGGCTGGCAGGAGCTGGTCTC	0.612000													42	107					0	0	0.008740	0	0
ZFAND4	93550	broad.mit.edu	37	10	46111945	46111945	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:46111945C>A	ENST00000374366.3	-	11	2366	c.1901G>T	c.(1900-1902)gGg>gTg	p.G634V	ZFAND4_ENST00000374371.2_3'UTR|ZFAND4_ENST00000374370.1_5'UTR|ZFAND4_ENST00000344646.5_Missense_Mutation_p.G708V			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	708							zinc ion binding										GTATCTCCTCCCTGCACTCTT	0.423000													35	22					1.26612e-14	1.53801e-14	0.015359	1	0
PCNT	5116	broad.mit.edu	37	21	47786839	47786839	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:47786839G>A	ENST00000359568.5	+	15	3057	c.2950G>A	c.(2950-2952)Gag>Aag	p.E984K	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	984					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GACCATCCGTGAGGAGCACAG	0.502000													40	111					0	0	0.006230	0	0
C10orf118	55088	broad.mit.edu	37	10	115895981	115895981	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:115895981C>T	ENST00000369287.3	-	8	1617	c.1351G>A	c.(1351-1353)Gag>Aag	p.E451K	C10orf118_ENST00000543782.1_Missense_Mutation_p.E49K	NM_018017.2	NP_060487.2	Q7Z3E2	CJ118_HUMAN	chromosome 10 open reading frame 118	451										NS(1)|autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(2)	24		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0161)|all cancers(201;0.0397)		GCATCAAGCTCATTTGATTTA	0.353000													5	40					0	0	0.014758	0	0
PLCL1	5334	broad.mit.edu	37	2	198949080	198949080	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:198949080T>C	ENST00000428675.1	+	2	1237	c.839T>C	c.(838-840)aTc>aCc	p.I280T	PLCL1_ENST00000437704.2_Missense_Mutation_p.I182T	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	280					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GAAGCCAAGATCAGGTTAAAG	0.418000													34	37					0	0	0.010818	0	0
TRRAP	8295	broad.mit.edu	37	7	98586403	98586403	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:98586403C>G	ENST00000359863.4	+	62	9626	c.9417C>G	c.(9415-9417)aaC>aaG	p.N3139K	TRRAP_ENST00000355540.3_Missense_Mutation_p.N3110K|TRRAP_ENST00000446306.3_Missense_Mutation_p.N3110K	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3139	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			AGGAGGCAAACAAAGCCTTCT	0.483000													9	155					0	0	0.004482	0	0
MBD1	4152	broad.mit.edu	37	18	47801575	47801575	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr18:47801575A>G	ENST00000591416.1	-	9	1264	c.833T>C	c.(832-834)aTg>aCg	p.M278T	MBD1_ENST00000587605.1_Missense_Mutation_p.M278T|MBD1_ENST00000585672.1_Missense_Mutation_p.M229T|MBD1_ENST00000585595.1_Missense_Mutation_p.M303T|MBD1_ENST00000457839.2_Missense_Mutation_p.M303T|MBD1_ENST00000436910.1_Missense_Mutation_p.M278T|MBD1_ENST00000424334.2_Missense_Mutation_p.M329T|MBD1_ENST00000398493.1_Missense_Mutation_p.M278T|MBD1_ENST00000398495.2_Missense_Mutation_p.M303T|MBD1_ENST00000382948.5_Missense_Mutation_p.M278T|MBD1_ENST00000353909.3_Missense_Mutation_p.M229T|MBD1_ENST00000349085.2_Missense_Mutation_p.M278T|MBD1_ENST00000591535.1_Missense_Mutation_p.M278T|MBD1_ENST00000347968.3_Missense_Mutation_p.M278T|MBD1_ENST00000339998.6_Missense_Mutation_p.M278T|MBD1_ENST00000269468.5_Missense_Mutation_p.M278T|MBD1_ENST00000269471.5_Missense_Mutation_p.M278T|MBD1_ENST00000590208.1_Missense_Mutation_p.M278T|MBD1_ENST00000398488.1_Missense_Mutation_p.M278T|MBD1_ENST00000588937.1_Missense_Mutation_p.M278T			Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1	278					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36						CCTGGCAGCCATCTTGGAGTC	0.647000													14	47					0	0	0.004990	0	0
AP1S3	130340	broad.mit.edu	37	2	224642492	224642492	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:224642492C>A	ENST00000443700.1	-	2	249	c.98G>T	c.(97-99)cGg>cTg	p.R33L	AP1S3_ENST00000396653.2_Missense_Mutation_p.R33L|AP1S3_ENST00000396654.2_Missense_Mutation_p.R33L|AP1S3_ENST00000409375.1_Missense_Mutation_p.R33L|AP1S3_ENST00000446015.2_Missense_Mutation_p.R33L|AP1S3_ENST00000423110.1_Missense_Mutation_p.R33L			Q96PC3	AP1S3_HUMAN	adaptor-related protein complex 1, sigma 3 subunit	33					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	coated pit|cytoplasmic vesicle membrane|cytosol|Golgi membrane|lysosomal membrane|membrane coat	protein transporter activity			NS(1)|breast(1)|lung(2)	4		Renal(207;0.0112)|Lung NSC(271;0.0186)|all_lung(227;0.0272)		Epithelial(121;7.6e-10)|all cancers(144;3.62e-07)|Lung(261;0.0086)|LUSC - Lung squamous cell carcinoma(224;0.00902)		AACAATTTCCCGGGTGATCTT	0.398000													19	27					7.07596e-05	7.7959e-05	0.006122	1	0
NXPE2	120406	broad.mit.edu	37	11	114569363	114569363	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr11:114569363G>A	ENST00000375475.5	+	3	827	c.729G>A	c.(727-729)caG>caA	p.Q243Q	NXPE2_ENST00000389586.4_Silent_p.Q243Q					neurexophilin and PC-esterase domain family, member 2																		AACTGTGCCAGTACATGGATG	0.473000													16	40					0	0	0.004007	0	0
ALG10B	144245	broad.mit.edu	37	12	38714744	38714744	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:38714744T>C	ENST00000308742.4	+	3	1467	c.1151T>C	c.(1150-1152)aTa>aCa	p.I384T	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	384					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				GGTTGGAGTATAGCTGACTCA	0.308000													29	37					0	0	0.006320	0	0
PRR23C	389152	broad.mit.edu	37	3	138762903	138762903	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr3:138762903C>T	ENST00000413199.1	-	1	831	c.560G>A	c.(559-561)aGc>aAc	p.S187N	MRPS22_ENST00000495075.1_Intron|PRR23C_ENST00000502927.2_Missense_Mutation_p.S187N	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	187										breast(2)|lung(7)|skin(2)	11						CCGGTAGGGGCTGAACATACT	0.652000													7	16					0	0	0.001984	0	0
TRPA1	8989	broad.mit.edu	37	8	72975736	72975736	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:72975736G>C	ENST00000262209.4	-	5	830	c.623C>G	c.(622-624)tCa>tGa	p.S208*		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	208						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TTTGGAACCTGAAAATGCAGC	0.328000													22	20					0	0	0.004656	0	0
PHYKPL	85007	broad.mit.edu	37	5	177642318	177642318	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:177642318G>A	ENST00000308158.5	-	9	1275	c.1041C>T	c.(1039-1041)ctC>ctT	p.L347L	PHYKPL_ENST00000481811.1_5'UTR	NM_153373.2	NP_699204.1			5-phosphohydroxy-L-lysine phospho-lyase																		TTTGCTGCCCGAGGAGCTGCA	0.592000													14	19					0	0	0.003163	0	0
IDNK	414328	broad.mit.edu	37	9	86258488	86258488	+	Silent	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:86258488C>G	ENST00000277124.8	+	6	1064	c.219C>G	c.(217-219)ctC>ctG	p.L73L	IDNK_ENST00000405990.3_3'UTR|IDNK_ENST00000376419.4_Silent_p.L119L|IDNK_ENST00000454393.1_Silent_p.L162L|IDNK_ENST00000376417.4_3'UTR	NM_001256915.1	NP_001243844.1	Q5T6J7	GNTK_HUMAN	idnK, gluconokinase homolog (E. coli)	119					carbohydrate metabolic process	cytoplasm	ATP binding|gluconokinase activity|shikimate kinase activity										AGATGCAGCTCCTGGTGGTCC	0.478000													16	47					0	0	0.004007	0	0
CDK17	5128	broad.mit.edu	37	12	96691485	96691485	+	Missense_Mutation	SNP	C	C	G			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:96691485C>G	ENST00000261211.3	-	8	1333	c.730G>C	c.(730-732)Gat>Cat	p.D244H	CDK17_ENST00000543119.2_Missense_Mutation_p.D244H|CDK17_ENST00000553042.1_5'UTR|CDK17_ENST00000542666.1_Missense_Mutation_p.D191H	NM_001170464.2|NM_002595.4	NP_001163935.1|NP_002586.2	Q00537	CDK17_HUMAN	cyclin-dependent kinase 17	244	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						TGTTTTAAATCCTTTAATAGT	0.303000													17	44					0	0	0.004990	0	0
RHCE	6006	broad.mit.edu	37	1	25729191	25729191	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:25729191C>A	ENST00000349320.3	-	5	722	c.334G>T	c.(334-336)Ggt>Tgt	p.G112C	RHCE_ENST00000243186.6_Missense_Mutation_p.G128C|RHCE_ENST00000346452.4_Missense_Mutation_p.G128C|RHCE_ENST00000374352.2_Missense_Mutation_p.G112C|RHCE_ENST00000349438.4_Missense_Mutation_p.G128C|RHCE_ENST00000340849.4_Missense_Mutation_p.G128C|RHCE_ENST00000495048.1_5'UTR|RHCE_ENST00000294413.7_Missense_Mutation_p.G128C|RHCE_ENST00000455194.1_Missense_Mutation_p.G128C|RHCE_ENST00000425135.1_Missense_Mutation_p.G128C|RHCE_ENST00000413854.1_Missense_Mutation_p.G128C			P18577	RHCE_HUMAN	Rh blood group, CcEe antigens	128						integral to plasma membrane				endometrium(8)|large_intestine(6)|lung(3)	17		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		AAGACAGCACCCGCTGAGATC	0.552000													38	53					1.836e-18	2.28146e-18	0.017118	1	0
COL5A2	1290	broad.mit.edu	37	2	189931462	189931462	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:189931462C>T	ENST00000374866.3	-	22	1722	c.1448G>A	c.(1447-1449)gGg>gAg	p.G483E		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	483					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TACTGGTTCCCCTTTTGGGCC	0.363000													49	105					0	0	0.014410	0	0
A2ML1	144568	broad.mit.edu	37	12	8995850	8995850	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:8995850C>T	ENST00000299698.7	+	12	1549	c.1369C>T	c.(1369-1371)Cgg>Tgg	p.R457W		NM_144670.4	NP_653271.2	B3KVV6	B3KVV6_HUMAN	alpha-2-macroglobulin-like 1	301						extracellular space	endopeptidase inhibitor activity			NS(2)|breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(2)|lung(36)|ovary(2)|skin(4)|stomach(1)|urinary_tract(1)	80						TGGCATCCACCGGCTAAACGG	0.542000													10	129					0	0	0.008291	0	0
THRA	7067	broad.mit.edu	37	17	38244755	38244755	+	Splice_Site	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:38244755T>C	ENST00000450525.2	+	8	1473		c.e8+2		THRA_ENST00000394121.4_Splice_Site|THRA_ENST00000264637.4_Splice_Site|THRA_ENST00000546243.1_Splice_Site|THRA_ENST00000584985.1_Splice_Site	NM_199334.3	NP_955366.1	P10827	THA_HUMAN	thyroid hormone receptor, alpha						negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(4)|prostate(1)	11	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	TGTCAACAGGTACCTGCTGAT	0.557000													12	236					0	0	0.013537	0	0
CSMD3	114788	broad.mit.edu	37	8	113331153	113331153	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:113331153G>A	ENST00000297405.5	-	47	7517	c.7273C>T	c.(7273-7275)Cca>Tca	p.P2425S	CSMD3_ENST00000352409.3_Missense_Mutation_p.P2355S|CSMD3_ENST00000343508.3_Missense_Mutation_p.P2385S|CSMD3_ENST00000455883.2_Missense_Mutation_p.P2321S	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2425	Sushi 13.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GTAAATCCTGGAAGACACTGA	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	33					0	0	0.009096	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43817723	43817723	+	Missense_Mutation	SNP	T	T	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr12:43817723T>A	ENST00000553158.1	-	29	4288	c.4289A>T	c.(4288-4290)gAt>gTt	p.D1430V	ADAMTS20_ENST00000395541.2_Missense_Mutation_p.D548V|ADAMTS20_ENST00000389420.3_Intron			P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	0	TSP type-1 11.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CACTTTAAGATCCTCCTATAA	0.338000													3	3					0	0	0.004672	0	0
DAB2	1601	broad.mit.edu	37	5	39394407	39394407	+	Nonsense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:39394407C>A	ENST00000545653.1	-	2	546	c.16G>T	c.(16-18)Gaa>Taa	p.E6*	DAB2_ENST00000509337.1_Nonsense_Mutation_p.E6*|DAB2_ENST00000339788.6_Nonsense_Mutation_p.E6*|DAB2_ENST00000320816.6_Nonsense_Mutation_p.E6*	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	6					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			GCACTTGTTTCTACTTCGTTA	0.483000													20	55					5.26018e-13	6.30888e-13	0.012319	1	0
MSL3	10943	broad.mit.edu	37	X	11778578	11778578	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:11778578G>C	ENST00000337339.2	+	3	269	c.242G>C	c.(241-243)aGa>aCa	p.R81T	MSL3_ENST00000312196.4_Missense_Mutation_p.R81T|MSL3_ENST00000398527.2_Missense_Mutation_p.R69T|MSL3_ENST00000361672.2_5'UTR|MSL3_ENST00000380693.3_5'UTR	NM_078628.1	NP_523352.1	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3 homolog (Drosophila)	81	Chromo.				histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|cervix(1)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	19						GAAAATCGTAGATTACAGCGT	0.348000													21	15					0	0	0.012319	0	0
SUV39H2	79723	broad.mit.edu	37	10	14939122	14939122	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr10:14939122G>A	ENST00000313519.5	+	2	506	c.275G>A	c.(274-276)gGa>gAa	p.G92E	SUV39H2_ENST00000378325.3_Intron|SUV39H2_ENST00000354919.6_Missense_Mutation_p.G152E	NM_001193425.1|NM_024670.3	NP_001180354.1|NP_078946.1	Q9H5I1	SUV92_HUMAN	suppressor of variegation 3-9 homolog 2 (Drosophila)	152	Chromo.				cell cycle|cell differentiation|chromatin assembly or disassembly|chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromatin|chromosome, centromeric region|nucleus	histone methyltransferase activity (H3-K9 specific)|protein binding|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)	19						AATCATAAAGGAATGATATTT	0.383000													12	35					0	0	0.010729	0	0
PRKDC	5591	broad.mit.edu	37	8	48752729	48752729	+	Silent	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:48752729T>C	ENST00000314191.2	-	56	7355	c.7299A>G	c.(7297-7299)gtA>gtG	p.V2433V	PRKDC_ENST00000338368.3_Silent_p.V2433V|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2434					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TGTCCAAACATACTTTTTGTC	0.338000								Non-homologous end-joining					3	4					0	0	0.004672	0	0
KEAP1	9817	broad.mit.edu	37	19	10602822	10602822	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr19:10602822C>A	ENST00000171111.5	-	3	1303	c.756G>T	c.(754-756)tgG>tgT	p.W252C	KEAP1_ENST00000393623.2_Missense_Mutation_p.W252C|KEAP1_ENST00000588024.1_5'UTR	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	252	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CGTACTTGACCCAGTTGATGC	0.622000													44	23					1.8453e-21	2.31579e-21	0.010771	1	0
HOXB2	3212	broad.mit.edu	37	17	46620955	46620955	+	Silent	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr17:46620955G>A	ENST00000330070.4	-	2	1713	c.546C>T	c.(544-546)ctC>ctT	p.L182L	HOXB-AS1_ENST00000504972.3_RNA	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	182					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						GCCTTTCGGTGAGGTCCAGCA	0.612000													28	182					0	0	0.009535	0	0
MIR509-1	574514	broad.mit.edu	37	X	146342052	146342052	+	RNA	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:146342052T>C	ENST00000385265.1	-	0	91					NR_030236.1|NR_030586.1																						GTATGTTGCATGTGTCATGCA	0.443000													4	57					0	0	0.014758	0	0
OSBPL9	114883	broad.mit.edu	37	1	52249623	52249623	+	Missense_Mutation	SNP	T	T	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:52249623T>C	ENST00000371710.3	+	18	1786	c.1604T>C	c.(1603-1605)aTa>aCa	p.I535T	OSBPL9_ENST00000486942.1_Missense_Mutation_p.I339T|OSBPL9_ENST00000361556.5_Missense_Mutation_p.I407T|OSBPL9_ENST00000530544.1_Missense_Mutation_p.I436T|OSBPL9_ENST00000453295.1_Missense_Mutation_p.I500T|OSBPL9_ENST00000447887.1_Missense_Mutation_p.I527T|OSBPL9_ENST00000462759.1_Missense_Mutation_p.I339T|OSBPL9_ENST00000435686.2_Missense_Mutation_p.I352T|OSBPL9_ENST00000428468.1_Missense_Mutation_p.I517T|OSBPL9_ENST00000531828.1_Missense_Mutation_p.I352T|OSBPL9_ENST00000371714.1_Missense_Mutation_p.I504T|OSBPL9_ENST00000337809.4_Missense_Mutation_p.I522T	NM_024586.5|NM_148906.2	NP_078862.4|NP_683704.2	Q96SU4	OSBL9_HUMAN	oxysterol binding protein-like 9	517					lipid transport		lipid binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(3)|pancreas(1)|prostate(3)|skin(1)	18						AACAAGAAGATACAATTCAAT	0.378000													6	27					0	0	0.001984	0	0
IL13	3596	broad.mit.edu	37	5	131995955	131995955	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr5:131995955G>A	ENST00000304506.3	+	4	436	c.422G>A	c.(421-423)cGc>cAc	p.R141H	IL13_ENST00000468334.1_3'UTR|AC004041.2_ENST00000435042.1_RNA	NM_002188.2	NP_002179.2	P35225	IL13_HUMAN	interleukin 13	141					cellular component movement|immune response|inflammatory response|signal transduction	extracellular space|soluble fraction	cytokine activity			large_intestine(1)|lung(1)|ovary(1)|skin(3)	6		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			AAACTTTTTCGCGAGGGACAG	0.413000													4	28					0	0	0.001168	0	0
HERC2	8924	broad.mit.edu	37	15	28517458	28517458	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr15:28517458G>C	ENST00000261609.7	-	9	1094	c.986C>G	c.(985-987)tCc>tGc	p.S329C		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	329					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding	p.S329F(1)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GCCCTGGGCGGAACGCTCATT	0.542000													5	23					0	0	0.014758	0	0
ADCY1	107	broad.mit.edu	37	7	45697356	45697356	+	Silent	SNP	G	G	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:45697356G>C	ENST00000297323.7	+	6	1201	c.1179G>C	c.(1177-1179)ctG>ctC	p.L393L	ADCY1_ENST00000432715.1_Silent_p.L168L	NM_021116.2	NP_066939.1	Q08828	ADCY1_HUMAN	adenylate cyclase 1 (brain)	393					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(33)|ovary(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	71					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Adenosine(DB00640)	AGGTGGATCTGAACATGCGTG	0.612000													5	17					0	0	0.014758	0	0
UGT2B7	7364	broad.mit.edu	37	4	69978250	69978250	+	Silent	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:69978250C>T	ENST00000305231.7	+	6	1432	c.1386C>T	c.(1384-1386)ttC>ttT	p.F462F	UGT2B7_ENST00000509763.1_3'UTR|UGT2B7_ENST00000508661.1_3'UTR	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	462					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GAGCAGTCTTCTGGATTGAAT	0.423000													26	83					0	0	0.006320	0	0
LIPT1	51601	broad.mit.edu	37	2	99778437	99778437	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:99778437C>T	ENST00000393477.3	+	4	369	c.17C>T	c.(16-18)tCa>tTa	p.S6L	LIPT1_ENST00000340066.1_Missense_Mutation_p.S6L|LIPT1_ENST00000393471.2_Missense_Mutation_p.S6L|LIPT1_ENST00000393473.2_Missense_Mutation_p.S6L|MRPL30_ENST00000410042.1_Intron|LIPT1_ENST00000393474.3_Missense_Mutation_p.S6L	NM_145197.2	NP_660198.1	Q9Y234	LIPT_HUMAN	lipoyltransferase 1	6					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity			large_intestine(6)|lung(1)	7					Lipoic Acid(DB00166)	ATCCCATTTTCAATGAAGAAT	0.323000													17	12					0	0	0.007413	0	0
OR14A16	284532	broad.mit.edu	37	1	247978907	247978921	+	In_Frame_Del	DEL	AGGACATTCCCCATC	AGGACATTCCCCATC	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr1:247978907_247978921delAGGACATTCCCCATC	ENST00000357627.1	-	1	110_124	c.111_125delGATGGGGAATGTCCT	c.(109-126)ctc>ct	p.LMGNVL37del		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	37					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G39E(1)|p.N40S(1)		breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						CATGATAATGAGGACATTCCCCATCAGGGCACACA	0.386													15	35	---	---	---	---					
CEP68	23177	broad.mit.edu	37	2	65296785	65296786	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr2:65296785_65296786insA	ENST00000377990.2	+	2	410_411	c.207_208insA	c.(205-210)ggctgafs	p.*70fs	CEP68_ENST00000260569.4_Frame_Shift_Ins_p.*70fs|CEP68_ENST00000537589.1_Intron|CEP68_ENST00000546106.1_Frame_Shift_Ins_p.*70fs	NM_015147.2	NP_055962.2	Q76N32	CEP68_HUMAN	centrosomal protein 68kDa	70					centrosome organization	centrosome				breast(1)|endometrium(6)|kidney(8)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32						GCTGGATTGGGACTGACCCTGG	0.649													61	56	---	---	---	---					
PRKG2	5593	broad.mit.edu	37	4	82074817	82074817	+	Frame_Shift_Del	DEL	A	A	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr4:82074817delA	ENST00000395578.1	-	7	1087	c.971delT	c.(970-972)tcfs	p.F324fs	PRKG2_ENST00000545647.1_5'UTR|PRKG2_ENST00000509169.1_5'UTR|PRKG2_ENST00000264399.1_Frame_Shift_Del_p.F324fs|PRKG2_ENST00000418486.2_Frame_Shift_Del_p.F324fs			Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	324					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			NS(1)|breast(4)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	37						TGCCAAAATGAAAAAGGTACT	0.343													8	138	---	---	---	---					
SAMD9	54809	broad.mit.edu	37	7	92733829	92733829	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr7:92733829delG	ENST00000379958.2	-	3	1851	c.1582delC	c.(1582-1584)ttfs	p.L528fs		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	528						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			TCATGTGTAAGAAATGAAATC	0.408													14	289	---	---	---	---					
GRHL2	79977	broad.mit.edu	37	8	102656404	102656405	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr8:102656404_102656405insT	ENST00000251808.3	+	13	1901_1902	c.1563_1564insT	c.(1561-1566)gattggfs	p.W522fs	GRHL2_ENST00000517674.1_3'UTR|GRHL2_ENST00000395927.1_Frame_Shift_Ins_p.W506fs	NM_024915.3	NP_079191.2	Q6ISB3	GRHL2_HUMAN	grainyhead-like 2 (Drosophila)	522						cytoplasm|nucleus	DNA binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			TGGAAGAGGAGTTTGGTCCAGT	0.495													11	53	---	---	---	---					
RORB	6096	broad.mit.edu	37	9	77286749	77286750	+	Frame_Shift_Ins	INS	-	-	A			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr9:77286749_77286750insA	ENST00000376896.2	+	9	1768_1769	c.1156_1157insA	c.(1156-1158)aaafs	p.K386fs	RORB_ENST00000396204.2_Frame_Shift_Ins_p.K397fs	NM_006914.3	NP_008845.2	Q92753	RORB_HUMAN	RAR-related orphan receptor B	397	Ligand-binding (Potential).				eye photoreceptor cell development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|visual perception	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(2)|large_intestine(4)|lung(1)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	12						GAAGCTTCAGGAAAAAATTTAT	0.446													7	26	---	---	---	---					
MTSS1L	92154	broad.mit.edu	37	16	70697685	70697694	+	Frame_Shift_Del	DEL	GGCTGGGGGT	GGCTGGGGGT	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr16:70697685_70697694delGGCTGGGGGT	ENST00000338779.6	-	15	2404_2413	c.2130_2139delACCCCCAGCC	c.(2128-2139)ccfs	p.PPPA710fs	FLJ00418_ENST00000597002.1_5'UTR	NM_138383.2	NP_612392.1	Q765P7	MTSSL_HUMAN	metastasis suppressor 1-like	710					filopodium assembly|signal transduction		actin binding|cytoskeletal adaptor activity|SH3 domain binding			breast(1)|central_nervous_system(2)|endometrium(1)|liver(1)|lung(1)|skin(1)	7						CGCTGGTGGCGGCTGGGGGTGGGGTGGGCG	0.733													3	3	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													7	2	---	---	---	---					
GRIPAP1	56850	broad.mit.edu	37	X	48849862	48849863	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-78-7154-01A-11D-2036-08	TCGA-78-7154-10A-01D-2036-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6a1d3fc1-6884-497f-93f8-95fcd33c6eb2	9d5e0598-a3b3-4ab7-9b53-18825c4ea3ab	g.chrX:48849862_48849863delTG	ENST00000376441.1	-	6	468_469	c.434_435delCA	c.(433-435)afs	p.T145fs	GRIPAP1_ENST00000376423.4_Intron|GRIPAP1_ENST00000376444.3_Frame_Shift_Del_p.T100fs|GRIPAP1_ENST00000376425.3_Frame_Shift_Del_p.T145fs	NM_020137.3	NP_064522.3	Q4V328	GRAP1_HUMAN	GRIP1 associated protein 1	145						early endosome				breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(2)	10						TCTGCAAGGCTGTGTTTTCAGC	0.614													11	6	---	---	---	---					
