Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
OR51M1	390059	broad.mit.edu	37	11	5410836	5410836	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:5410836C>A	ENST00000328611.3	+	1	230	c.208C>A	c.(208-210)Ccc>Acc	p.P70T	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron	NM_001004756.2	NP_001004756.2	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M, member 1	70						integral to membrane	olfactory receptor activity			NS(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|upper_aerodigestive_tract(1)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCTGCACACACCCATGTACTA	0.468000													7	115					8.12818e-05	0.000259086	0.001984	1	0
UNC45A	55898	broad.mit.edu	37	15	91482981	91482981	+	Silent	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr15:91482981G>A	ENST00000394275.2	+	8	1237	c.402G>A	c.(400-402)acG>acA	p.T134T	UNC45A_ENST00000418476.2_Silent_p.T149T|UNC45A_ENST00000553671.2_3'UTR	NM_001039675.1	NP_001034764.1	Q9H3U1	UN45A_HUMAN	unc-45 homolog A (C. elegans)	149					cell differentiation|muscle organ development	nucleus|perinuclear region of cytoplasm	protein binding	p.T149T(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			TGTCCTCGACGGATGCCAAAG	0.483000													27	29					0	0	0.012213	0	0
LPA	4018	broad.mit.edu	37	6	160999606	160999606	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr6:160999606T>G	ENST00000447678.1	-	28	4540	c.4420A>C	c.(4420-4422)Aca>Cca	p.T1474P	LPA_ENST00000316300.5_Missense_Mutation_p.T1474P	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3982	Kringle 13.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GTGGGAGTTGTGAGGACACTC	0.498000													6	109					0	0	0.003080	0	0
DOCK10	55619	broad.mit.edu	37	2	225630503	225630503	+	Missense_Mutation	SNP	G	G	C			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr2:225630503G>C	ENST00000409592.3	-	56	6591	c.6478C>G	c.(6478-6480)Cga>Gga	p.R2160G	DOCK10_ENST00000258390.7_Missense_Mutation_p.R2166G			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	2166							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		CTAATTACTCGAGTGCAGGTT	0.502000													8	25					0	0	0.006214	0	0
TRGC2	6967	broad.mit.edu	37	7	38279515	38279515	+	RNA	SNP	G	G	A	rs150812430	by1000genomes	TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr7:38279515G>A	ENST00000436911.2	-	0	678																											GTACACACATGAGAACTGAAA	0.433000													6	5					0	0	0.001984	0	0
ARHGAP5	394	broad.mit.edu	37	14	32561096	32561096	+	Silent	SNP	T	T	C			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr14:32561096T>C	ENST00000345122.3	+	2	1536	c.1221T>C	c.(1219-1221)acT>acC	p.T407T	ARHGAP5_ENST00000539826.2_Silent_p.T407T|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000556611.1_Silent_p.T407T|ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000432921.1_Silent_p.T407T	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	407	FF 2.				cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		TCCTGAGCACTTTAGAAGCTG	0.378000													24	86					0	0	0.004656	0	0
IGHD	3495	broad.mit.edu	37	14	106311905	106311905	+	RNA	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr14:106311905G>A	ENST00000390556.2	-	0	105																											AGTCACGGACGTTGGGTGGTA	0.552000													17	32					0	0	0.004007	0	0
KDM1B	221656	broad.mit.edu	37	6	18218071	18218071	+	Missense_Mutation	SNP	T	T	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr6:18218071T>G	ENST00000388870.2	+	21	2584	c.2343T>G	c.(2341-2343)gaT>gaG	p.D781E	KDM1B_ENST00000546309.2_Missense_Mutation_p.D71E|KDM1B_ENST00000397244.1_Missense_Mutation_p.D549E|KDM1B_ENST00000297792.5_Missense_Mutation_p.D548E			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	780					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						AGGCCTACGATATCATTGCTG	0.438000													6	58					0	0	0.001168	0	0
GRIK5	2901	broad.mit.edu	37	19	42558472	42558472	+	Splice_Site	SNP	C	C	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr19:42558472C>T	ENST00000262895.3	-	8	1055	c.1056_splice	c.e8+1	p.M352_splice	GRIK5_ENST00000301218.4_Splice_Site_p.M352_splice|GRIK5_ENST00000593562.1_Splice_Site_p.M352_splice	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	352						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	TCGGGCTCACCATGCGCAGGT	0.647000													18	45					0	0	0.008871	0	0
VSIG1	340547	broad.mit.edu	37	X	107310218	107310218	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chrX:107310218G>A	ENST00000415430.3	+	4	535	c.374G>A	c.(373-375)cGa>cAa	p.R125Q	VSIG1_ENST00000485533.1_3'UTR|VSIG1_ENST00000217957.5_Missense_Mutation_p.R89Q	NM_001170553.1	NP_001164024.1	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	89	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17						TTTAAAGATCGAATTACAGGG	0.438000													8	95					0	0	0.003080	0	0
TRIM68	55128	broad.mit.edu	37	11	4623587	4623587	+	Missense_Mutation	SNP	C	C	T	rs150937700	byFrequency	TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:4623587C>T	ENST00000300747.5	-	4	867	c.578G>A	c.(577-579)cGa>cAa	p.R193Q		NM_018073.6	NP_060543.5	Q6AZZ1	TRI68_HUMAN	tripartite motif containing 68	193					protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	15		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CTCTAGTAATCGCTGGTATTT	0.517000													10	53					0	0	0.006214	0	0
FOXRED2	80020	broad.mit.edu	37	22	36902334	36902334	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr22:36902334C>T	ENST00000397224.4	-	2	229	c.136G>A	c.(136-138)Gcc>Acc	p.A46T	FOXRED2_ENST00000216187.6_Missense_Mutation_p.A46T|FOXRED2_ENST00000397223.4_Missense_Mutation_p.A46T	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	46					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						AGGAAGTAGGCCATCTGCAGG	0.736000													5	4					0	0	0.000602	0	0
OR2AG1	144125	broad.mit.edu	37	11	6806758	6806758	+	Missense_Mutation	SNP	A	A	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:6806758A>G	ENST00000307401.4	+	1	511	c.490A>G	c.(490-492)Atg>Gtg	p.M164V		NM_001004489.2	NP_001004489.1	Q9H205	O2AG1_HUMAN	olfactory receptor, family 2, subfamily AG, member 1	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(13)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)		Epithelial(150;2.19e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		CGTGTATACCATGCACTATCC	0.532000													5	108					0	0	0.000602	0	0
FAM65C	140876	broad.mit.edu	37	20	49247380	49247380	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr20:49247380G>A	ENST00000327979.2	-	2	416	c.5C>T	c.(4-6)tCg>tTg	p.S2L	FAM65C_ENST00000045083.2_Missense_Mutation_p.S2L|FAM65C_ENST00000535356.1_Missense_Mutation_p.S6L			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	2										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CAACCTCACCGACATGGTGGT	0.662000													4	18					0	0	0.000602	0	0
CSMD3	114788	broad.mit.edu	37	8	113402962	113402962	+	Nonsense_Mutation	SNP	G	G	C			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr8:113402962G>C	ENST00000297405.5	-	36	6109	c.5865C>G	c.(5863-5865)taC>taG	p.Y1955*	CSMD3_ENST00000455883.2_Nonsense_Mutation_p.Y1851*|CSMD3_ENST00000343508.3_Nonsense_Mutation_p.Y1915*|CSMD3_ENST00000352409.3_Nonsense_Mutation_p.Y1885*	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1955	CUB 11.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAGGCTCAGGGTATCCAGGTG	0.398000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			18	34					0	0	0.004990	0	0
GRIK3	2899	broad.mit.edu	37	1	37346266	37346266	+	Silent	SNP	C	C	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr1:37346266C>G	ENST00000373091.3	-	3	535	c.519G>C	c.(517-519)cgG>cgC	p.R173R	GRIK3_ENST00000373093.4_Silent_p.R173R	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	173					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CGGTGGCTGACCGCCACTTGA	0.622000													69	210					0	0	0.014410	0	0
ATXN2	6311	broad.mit.edu	37	12	111923133	111923133	+	Silent	SNP	A	A	C			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr12:111923133A>C	ENST00000377617.3	-	18	3101	c.2940T>G	c.(2938-2940)ccT>ccG	p.P980P	ATXN2_ENST00000535949.1_Silent_p.P691P|ATXN2_ENST00000389153.4_Silent_p.P715P|ATXN2_ENST00000542287.2_Silent_p.P715P|ATXN2_ENST00000550104.1_Intron	NM_002973.3	NP_002964.3	Q99700	ATX2_HUMAN	ataxin 2	980	Pro-rich.				cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(5)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37						TTGGGTATAAAGGCTTGAGAG	0.373000													46	96					0	0	0.014410	0	0
GRM5	2915	broad.mit.edu	37	11	88337977	88337977	+	Missense_Mutation	SNP	G	G	A	rs148343362		TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:88337977G>A	ENST00000418177.2	-	5	1670	c.1303C>T	c.(1303-1305)Cgg>Tgg	p.R435W	GRM5_ENST00000393297.1_Missense_Mutation_p.R435W|GRM5_ENST00000305447.4_Missense_Mutation_p.R435W|GRM5_ENST00000455756.2_Missense_Mutation_p.R435W|GRM5_ENST00000305432.5_Missense_Mutation_p.R435W			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	435					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.R435W(3)		NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AAAAGTTTCCGTCCATCAATT	0.483000													33	53					0	0	0.010818	0	0
CHD7	55636	broad.mit.edu	37	8	61766029	61766029	+	Missense_Mutation	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr8:61766029G>A	ENST00000423902.2	+	31	7224	c.6745G>A	c.(6745-6747)Gat>Aat	p.D2249N	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2249	Glu-rich.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GGAGGATGACGATAAGTCGGA	0.522000													5	53					0	0	0.000602	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42446614	42446614	+	Missense_Mutation	SNP	G	G	A	rs142310375		TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr15:42446614G>A	ENST00000397272.3	-	3	318	c.227C>T	c.(226-228)gCg>gTg	p.A76V	PLA2G4F_ENST00000382396.4_Missense_Mutation_p.A76V	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	76	C2.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		GCTTGGGGACGCCGTGGGCAG	0.592000													8	24					0	0	0.003080	0	0
CNTN5	53942	broad.mit.edu	37	11	99872788	99872788	+	Silent	SNP	G	G	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:99872788G>A	ENST00000524871.1	+	9	1190	c.900G>A	c.(898-900)ccG>ccA	p.P300P	CNTN5_ENST00000418526.2_Silent_p.P226P|CNTN5_ENST00000527185.1_Silent_p.P300P|CNTN5_ENST00000528682.1_Silent_p.P300P|CNTN5_ENST00000279463.3_Silent_p.P300P	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	300	Ig-like C2-type 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AATATGAGCCGAAAATTGAGG	0.363000													7	24					0	0	0.006214	0	0
REL	5966	broad.mit.edu	37	2	61149129	61149129	+	Missense_Mutation	SNP	C	C	T	rs144119768	by1000genomes	TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr2:61149129C>T	ENST00000295025.7	+	11	1639	c.1319C>T	c.(1318-1320)tCg>tTg	p.S440L	REL_ENST00000394479.3_Missense_Mutation_p.S408L	NM_002908.2	NP_002899.1	Q04864	REL_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog	440					positive regulation of I-kappaB kinase/NF-kappaB cascade	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(3)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	16	all_hematologic(2;0.0797)	Ovarian(717;0.0728)	LUSC - Lung squamous cell carcinoma(5;6.2e-08)|Lung(5;1.65e-06)|Epithelial(17;0.064)|all cancers(80;0.221)			CCTTCTAATTCGCAAGGTATC	0.458000			A		Hodgkin Lymphoma								11	66					0	0	0.010729	0	0
XK	7504	broad.mit.edu	37	X	37553663	37553663	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chrX:37553663C>A	ENST00000378616.3	+	2	573	c.370C>A	c.(370-372)Cag>Aag	p.Q124K	TM4SF2_ENST00000465127.1_Intron	NM_021083.2	NP_066569.1	P51811	XK_HUMAN	X-linked Kx blood group (McLeod syndrome)	124					amino acid transport	integral to membrane	protein binding|transporter activity			breast(1)|endometrium(4)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	15		all_lung(315;0.175)				GGAGGTGGGCCAGGCAGAAGG	0.537000													7	6					2.0095e-06	6.83229e-06	0.001984	1	0
TMEM63B	55362	broad.mit.edu	37	6	44102330	44102330	+	Silent	SNP	C	C	G			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr6:44102330C>G	ENST00000259746.9	+	2	192	c.9C>G	c.(7-9)ccC>ccG	p.P3P	TMEM63B_ENST00000323267.6_Silent_p.P3P			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	3						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			CCATGCTGCCCTTTCTGCTGG	0.652000													10	21					0	0	0.006214	0	0
ARHGAP4	393	broad.mit.edu	37	X	153184369	153184369	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chrX:153184369C>A	ENST00000370028.3	-	8	1126	c.1069G>T	c.(1069-1071)Gac>Tac	p.D357Y	ARHGAP4_ENST00000350060.5_Missense_Mutation_p.D317Y|ARHGAP4_ENST00000370016.1_Missense_Mutation_p.D296Y|ARHGAP4_ENST00000537206.1_Missense_Mutation_p.D294Y|ARHGAP4_ENST00000393721.1_Intron	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	317					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TTGGCTTTGTCCCCTGGAGGA	0.647000													6	71					0.00116845	0.00361156	0.001168	1	0
OR51T1	401665	broad.mit.edu	37	11	4903940	4903940	+	Missense_Mutation	SNP	C	C	A			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr11:4903940C>A	ENST00000380378.1	+	1	892	c.892C>A	c.(892-894)Cca>Aca	p.P298T	OR51T1_ENST00000322049.1_Missense_Mutation_p.P271T|MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		CCACTCCACCCCAAGGGTGCT	0.493000													9	136					2.17888e-05	7.16921e-05	0.006214	1	0
RPS6KA3	6197	broad.mit.edu	37	X	20181107	20181107	+	Missense_Mutation	SNP	C	C	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chrX:20181107C>T	ENST00000379565.3	-	19	2023	c.1816G>A	c.(1816-1818)Gtc>Atc	p.V606I	RPS6KA3_ENST00000479809.1_5'UTR|RPS6KA3_ENST00000379548.4_Missense_Mutation_p.V576I|RPS6KA3_ENST00000544447.1_Missense_Mutation_p.V578I|RPS6KA3_ENST00000540702.1_Missense_Mutation_p.V577I	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	606	Protein kinase 2.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						TAGAGTAGGACACCAAGACTC	0.338000													39	61					0	0	0.013114	0	0
ARPC2	10109	broad.mit.edu	37	2	219099087	219099087	+	Missense_Mutation	SNP	G	G	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr2:219099087G>T	ENST00000295685.10	+	4	496	c.235G>T	c.(235-237)Gtg>Ttg	p.V79L	ARPC2_ENST00000315717.5_Missense_Mutation_p.V79L	NM_005731.2	NP_005722.1	O15144	ARPC2_HUMAN	actin related protein 2/3 complex, subunit 2, 34kDa	79					cellular component movement	Arp2/3 protein complex|cell projection|Golgi apparatus	actin binding|structural constituent of cytoskeleton			cervix(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)	6		Renal(207;0.0474)		Epithelial(149;1.21e-06)|all cancers(144;0.000212)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0103)		ATTAAAGAGGGTGTACGGGAG	0.343000													12	77					3.27435e-08	1.15167e-07	0.002450	1	0
CNTNAP3B	728577	broad.mit.edu	37	9	43844265	43844265	+	Frame_Shift_Del	DEL	G	G	-			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr9:43844265delG	ENST00000377564.3	+	10	1992	c.1599delG	c.(1597-1599)gcfs	p.A533fs		NM_001201380.1	NP_001188309.1	Q96NU0	CNT3B_HUMAN	contactin associated protein-like 3B	533	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			central_nervous_system(1)|endometrium(2)|lung(3)|pancreas(1)|prostate(3)	10						AGCAGGGGGCGCTGGGGAGTT	0.542													5	10	---	---	---	---					
SCN8A	6334	broad.mit.edu	37	12	52200312	52200313	+	Frame_Shift_Ins	INS	-	-	T			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr12:52200312_52200313insT	ENST00000354534.5	+	27	5220_5221	c.5042_5043insT	c.(5041-5043)gatfs	p.D1681fs	SCN8A_ENST00000545061.1_Frame_Shift_Ins_p.D1640fs	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1681					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	CACGAGGCTGGTATCGATGACA	0.485													29	88	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74394379	74394380	+	RNA	INS	-	-	A	rs142790741	by1000genomes	TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr16:74394379_74394380insA	ENST00000429810.2	-	0	435																											TAGTCATCCTTAAACAAAATTC	0.347													4	4	---	---	---	---					
BTBD3	22903	broad.mit.edu	37	20	11899098	11899100	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-78-7163-01A-12D-2063-08	TCGA-78-7163-11A-01D-2063-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	1cdd6a30-03ce-4c46-86ab-8042ef4265b6	3f063fbc-81bd-4954-8c0e-6c03287f17af	g.chr20:11899098_11899100delAAG	ENST00000405977.1	+	2	800_802	c.175_177delAAG	c.(175-177)del	p.K61del	BTBD3_ENST00000399006.2_5'UTR|BTBD3_ENST00000254977.3_5'UTR|BTBD3_ENST00000378226.2_In_Frame_Del_p.K61del|RP4-742J24.2_ENST00000439529.1_RNA			Q9Y2F9	BTBD3_HUMAN	BTB (POZ) domain containing 3	61										breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(18)|ovary(3)|skin(2)	34						GAAGACTAAAAAGAAGAAGATGG	0.453													51	178	---	---	---	---					
