Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ANXA4	307	broad.mit.edu	37	2	70031721	70031721	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:70031721C>G	ENST00000394295.4	+	4	402	c.154C>G	c.(154-156)Cag>Gag	p.Q52E	ANXA4_ENST00000409920.1_Missense_Mutation_p.Q52E|ANXA4_ENST00000536030.1_5'UTR	NM_001153.3	NP_001144.1	P09525	ANXA4_HUMAN	annexin A4	50					anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)	11						CGCCCAGCGCCAGGAGATCAG	0.577000													3	18					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108412209	108412209	+	Silent	SNP	T	T	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr10:108412209T>A	ENST00000263054.6	-	18	2413	c.2406A>T	c.(2404-2406)atA>atT	p.I802I	SORCS1_ENST00000369698.1_Silent_p.I337I|SORCS1_ENST00000344440.6_Silent_p.I802I	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	802						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CAGCCGTGACTATCCGCAGCC	0.532000													7	55					0	0	1	0	0
ASIC4	55515	broad.mit.edu	37	2	220396515	220396515	+	Silent	SNP	C	C	T	rs148269786		TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:220396515C>T	ENST00000358078.4	+	2	1013	c.999C>T	c.(997-999)aaC>aaT	p.N333N	ASIC4_ENST00000347842.3_Silent_p.N333N|ASIC4_ENST00000473709.1_3'UTR			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	333						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										ACACCTTCAACGCGGACCCGC	0.617000													16	49					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625905	29625905	+	Missense_Mutation	SNP	T	T	C	rs137871677	by1000genomes	TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr20:29625905T>C	ENST00000278882.3	+	5	529	c.149T>C	c.(148-150)cTt>cCt	p.L50P	FRG1B_ENST00000358464.4_Missense_Mutation_p.L50P|FRG1B_ENST00000439954.2_Missense_Mutation_p.L55P														p.L50P(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGAAAATATCTTGGTATAAAT	0.333000													3	54					0	0	1	0	0
ZNF302	55900	broad.mit.edu	37	19	35173711	35173711	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr19:35173711C>G	ENST00000505365.2	+	3	375	c.39C>G	c.(37-39)ttC>ttG	p.F13L	ZNF302_ENST00000423823.2_Missense_Mutation_p.F13L|ZNF302_ENST00000509528.1_Intron|ZNF302_ENST00000457781.2_Missense_Mutation_p.F13L|ZNF302_ENST00000507959.1_Missense_Mutation_p.F13L|ZNF302_ENST00000505242.1_Missense_Mutation_p.F13L|ZNF302_ENST00000446502.2_Missense_Mutation_p.F57L			Q9NR11	ZN302_HUMAN	zinc finger protein 302	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(1)|large_intestine(2)|lung(2)|skin(1)	6	all_lung(56;6.16e-07)|Lung NSC(56;9.71e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CTATAGACTTCTCTCATGAAG	0.433000													5	30					0	0	1	0	0
TYRO3	7301	broad.mit.edu	37	15	41861142	41861142	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr15:41861142G>A	ENST00000263798.3	+	9	1398	c.1174G>A	c.(1174-1176)Gta>Ata	p.V392I	TYRO3_ENST00000559066.1_Missense_Mutation_p.V347I	NM_006293.3	NP_006284.2	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase	392	Fibronectin type-III 2.					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(26)|ovary(3)|prostate(1)	43		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GGACCTGATCGTACGTGTGTG	0.587000													9	18					0	0	1	0	0
FAM71E1	112703	broad.mit.edu	37	19	50978613	50978613	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr19:50978613C>T	ENST00000600100.1	-	3	872	c.508G>A	c.(508-510)Gcc>Acc	p.A170T	FAM71E1_ENST00000595790.1_Missense_Mutation_p.A154T			Q6IPT2	F71E1_HUMAN	family with sequence similarity 71, member E1	170										breast(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.0077)|GBM - Glioblastoma multiforme(134;0.026)		TTCTCCTTGGCAGGGCCGGCC	0.647000													9	15					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51515710	51515710	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr11:51515710G>T	ENST00000328188.1	+	1	429	c.429G>T	c.(427-429)atG>atT	p.M143I		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						CCCTGCTAATGGGAGTGGTGT	0.458000													12	120					5.01169e-05	5.24662e-05	1	1	0
ASAP3	55616	broad.mit.edu	37	1	23777978	23777978	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr1:23777978G>C	ENST00000336689.3	-	5	511	c.467C>G	c.(466-468)gCc>gGc	p.A156G	ASAP3_ENST00000437606.2_Intron	NM_017707.3	NP_060177.2	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	156					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	24						TTACATTTTGGCTTCATAGTC	0.478000													3	57					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66637825	66637825	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr11:66637825T>C	ENST00000393960.1	-	9	1132	c.851A>G	c.(850-852)gAc>gGc	p.D284G	PC_ENST00000524491.1_Missense_Mutation_p.D244G|PC_ENST00000393955.2_Missense_Mutation_p.D284G|PC_ENST00000393958.2_Missense_Mutation_p.D284G|PC_ENST00000355677.3_Missense_Mutation_p.D284G	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	284	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	AAGCTGCGGGTCCAGGTGGGC	0.637000													18	36					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000455089.1_Missense_Mutation_p.L813R|EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			58	69					0	0	1	0	0
ZNF746	155061	broad.mit.edu	37	7	149191094	149191094	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr7:149191094G>A	ENST00000461958.2	-	3	588	c.392C>T	c.(391-393)aCg>aTg	p.T131M	ZNF746_ENST00000340622.3_Missense_Mutation_p.T131M|ZNF746_ENST00000458143.2_Missense_Mutation_p.T131M			Q6NUN9	ZN746_HUMAN	zinc finger protein 746	131	KRAB.				negative regulation of transcription, DNA-dependent|neuron death|regulation of cell death|transcription, DNA-dependent	cytoplasm|nucleus	transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			GGAGACCAGCGTCTCGTAGTT	0.507000													27	115					0	0	1	0	0
ARHGAP4	393	broad.mit.edu	37	X	153175377	153175377	+	Splice_Site	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chrX:153175377G>A	ENST00000370028.3	-	20	2409	c.2350_splice	c.e20-1	p.D784_splice	ARHGAP4_ENST00000370016.1_Splice_Site_p.D723_splice|ARHGAP4_ENST00000467421.1_5'UTR|ARHGAP4_ENST00000350060.5_Splice_Site_p.D744_splice|ARHGAP4_ENST00000393721.1_Splice_Site_p.D566_splice|ARHGAP4_ENST00000537206.1_Splice_Site_p.D721_splice	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	744	SH3.				apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCCCTCCAGGTCTGGGGAGG	0.687000													3	18					0	0	1	0	0
DCX	1641	broad.mit.edu	37	X	110654184	110654184	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chrX:110654184G>T	ENST00000338081.3	-	1	190	c.19C>A	c.(19-21)Cat>Aat	p.H7N	DCX_ENST00000371993.2_Intron|DCX_ENST00000496551.1_Intron|DCX_ENST00000356915.2_Intron|DCX_ENST00000488120.1_Intron|DCX_ENST00000356220.3_Intron	NM_000555.3	NP_000546.2	O43602	DCX_HUMAN	doublecortin	7					axon guidance|central nervous system development|intracellular signal transduction	cytosol|microtubule associated complex	microtubule binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|skin(6)|upper_aerodigestive_tract(1)	41						CAATGACTATGAAGGGGGAGT	0.438000													6	90					3.59834e-05	3.8268e-05	1	1	0
MATN3	4148	broad.mit.edu	37	2	20197005	20197005	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:20197005G>T	ENST00000407540.3	-	6	1246	c.1184C>A	c.(1183-1185)gCc>gAc	p.A395D	AC079145.4_ENST00000416575.1_RNA|MATN3_ENST00000421259.2_Missense_Mutation_p.A353D	NM_002381.4	NP_002372.1	O15232	MATN3_HUMAN	matrilin 3	395	EGF-like 4.				skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(6)|skin(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGAGCCTAGGGCACACTTGTC	0.453000													4	9					0.00909568	0.00909568	1	1	0
HSD17B12	51144	broad.mit.edu	37	11	43876764	43876764	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr11:43876764G>A	ENST00000278353.4	+	11	1024	c.905G>A	c.(904-906)cGg>cAg	p.R302Q	RP11-613D13.5_ENST00000530450.1_RNA	NM_016142.2	NP_057226.1	Q53GQ0	DHB12_HUMAN	hydroxysteroid (17-beta) dehydrogenase 12	302					long-chain fatty-acyl-CoA biosynthetic process|steroid biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	estradiol 17-beta-dehydrogenase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity			endometrium(2)|large_intestine(4)|lung(4)	10						AAGTCTACACGGGCTCACTAT	0.408000													9	51					0	0	1	0	0
GDF7	151449	broad.mit.edu	37	2	20871168	20871168	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:20871168G>A	ENST00000272224.3	+	2	1912	c.1336G>A	c.(1336-1338)Gcc>Acc	p.A446T		NM_182828.2	NP_878248.2	Q7Z4P5	GDF7_HUMAN	growth differentiation factor 7	446					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			breast(1)|cervix(1)|endometrium(2)|lung(1)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTGGTGGAGGCCTGCGGCTG	0.672000													6	8					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20766691	20766691	+	Missense_Mutation	SNP	G	G	A	rs111647033	byFrequency	TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr7:20766691G>A	ENST00000404938.2	+	22	3306	c.2654G>A	c.(2653-2655)cGt>cAt	p.R885H	ABCB5_ENST00000258738.6_Missense_Mutation_p.R440H	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	440					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity	p.R440H(1)		breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GAGAATATACGTACTATAGTG	0.318000													21	32					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18155411	18155411	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr17:18155411G>C	ENST00000327031.4	-	11	1373	c.1148C>G	c.(1147-1149)gCa>gGa	p.A383G	FLII_ENST00000379450.4_Missense_Mutation_p.A298G|FLII_ENST00000545457.2_Missense_Mutation_p.A329G|FLII_ENST00000579294.1_Missense_Mutation_p.A372G|FLII_ENST00000578558.1_Missense_Mutation_p.A383G	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	383	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					GGCACGGTCTGCGGGCTTGGG	0.652000													9	23					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578556	7578556	+	Splice_Site	SNP	T	T	C			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr17:7578556T>C	ENST00000420246.2	-	5	508		c.e5-2		TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site|TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(34)|p.0?(8)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGGAGTACTGTAGGAAGAG	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	12					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21547143	21547143	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr14:21547143C>T	ENST00000298694.4	+	11	2474	c.2347C>T	c.(2347-2349)Cgg>Tgg	p.R783W	ARHGEF40_ENST00000298693.3_Missense_Mutation_p.R783W			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	783					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						GCAAGAGCAGCGGCAGTGCCT	0.622000													4	33					0	0	1	0	0
NT5M	56953	broad.mit.edu	37	17	17209911	17209911	+	Silent	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr17:17209911C>T	ENST00000389022.4	+	2	538	c.322C>T	c.(322-324)Ctg>Ttg	p.L108L		NM_020201.3	NP_064586.1	Q9NPB1	NT5M_HUMAN	5',3'-nucleotidase, mitochondrial	108					DNA replication|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	5'-nucleotidase activity|metal ion binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)	4						ACTTGAGCCTCTGCCAGGGGC	0.502000													9	77					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238234246	238234246	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:238234246G>T	ENST00000295550.4	-	43	9902	c.9450C>A	c.(9448-9450)aaC>aaA	p.N3150K	COL6A3_ENST00000473258.1_5'UTR|COL6A3_ENST00000347401.3_Missense_Mutation_p.N2949K|COL6A3_ENST00000346358.4_Missense_Mutation_p.N2950K|COL6A3_ENST00000472056.1_Missense_Mutation_p.N2543K|COL6A3_ENST00000353578.4_Missense_Mutation_p.N2944K|COL6A3_ENST00000409809.1_Missense_Mutation_p.N2944K	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	3150	BPTI/Kunitz inhibitor.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		ATCCAAATTTGTTTTCGTTTC	0.388000													12	60					6.31663e-08	6.82603e-08	1	1	0
IFNA16	3449	broad.mit.edu	37	9	21216753	21216753	+	Silent	SNP	T	T	G			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr9:21216753T>G	ENST00000380216.1	-	1	557	c.552A>C	c.(550-552)ggA>ggC	p.G184G		NM_002173.2	NP_002164.1	P05015	IFN16_HUMAN	interferon, alpha 16	184					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)	13				Lung(24;2.12e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		TCCTTCTTAATCCTTTTTGCA	0.378000													25	95					0	0	1	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50658074	50658074	+	Splice_Site	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr22:50658074C>T	ENST00000439308.2	-	18	4865	c.4374_splice	c.e18+1	p.C1458_splice	TUBGCP6_ENST00000248846.5_Splice_Site_p.M1438_splice|TUBGCP6_ENST00000491449.1_5'UTR	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	0					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TGCACTCACACATGGACTCGT	0.672000													5	73					0	0	1	0	0
SLC2A10	81031	broad.mit.edu	37	20	45355558	45355558	+	Silent	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr20:45355558C>T	ENST00000359271.2	+	3	1594	c.1344C>T	c.(1342-1344)ttC>ttT	p.F448F		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	448						endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				GAAGAGCCTTCGCCTTCTGCA	0.567000													37	41					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37708411	37708411	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr9:37708411G>A	ENST00000539465.1	+	4	868	c.275G>A	c.(274-276)gGc>gAc	p.G92D	FRMPD1_ENST00000377765.3_Missense_Mutation_p.G92D|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	92	PDZ.					cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		TCTGCTCACGGCAAGCTTTTC	0.493000													10	57					0	0	1	0	0
MT-ND1	4535	broad.mit.edu	37	MT	3814	3814	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chrM:3814G>A	ENST00000361390.2	+	1	508	c.508G>A	c.(508-510)Gaa>Aaa	p.170_170insK						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						TCACAACACAAGAACACCTCT	0.448000													5	76					0	0	1	0	0
GAPVD1	26130	broad.mit.edu	37	9	128064472	128064472	+	Silent	SNP	T	T	G			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr9:128064472T>G	ENST00000470056.1	+	3	556	c.396T>G	c.(394-396)gtT>gtG	p.V132V	GAPVD1_ENST00000394084.1_Silent_p.V132V|GAPVD1_ENST00000495955.1_Silent_p.V132V|GAPVD1_ENST00000394104.2_Silent_p.V132V|GAPVD1_ENST00000394105.2_Silent_p.V132V|GAPVD1_ENST00000265956.4_Silent_p.V132V|GAPVD1_ENST00000394083.2_Silent_p.V132V|GAPVD1_ENST00000297933.6_Silent_p.V132V|GAPVD1_ENST00000312123.9_Silent_p.V132V			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	132	Ras-GAP.				endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TTTACACAGTTTTTACCTCCC	0.393000													3	84					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100654692	100654692	+	Silent	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr8:100654692G>A	ENST00000358544.2	+	34	6060	c.5949G>A	c.(5947-5949)gtG>gtA	p.V1983V	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Silent_p.V1958V	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1983					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			TTGATGCTGTGCTTAAAGGGG	0.398000													8	7					0	0	1	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117774675	117774675	+	Splice_Site	SNP	T	T	C			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr11:117774675T>C	ENST00000528626.1	-	10	1491	c.1419_splice	c.e10+1	p.Q473_splice	TMPRSS13_ENST00000445164.2_Splice_Site_p.Q508_splice|TMPRSS13_ENST00000430170.2_Splice_Site_p.Q508_splice|TMPRSS13_ENST00000524993.1_Splice_Site_p.Q508_splice	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	503	Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		TACCCTCACCTGGCAGGAGTC	0.587000													5	7					0	0	1	0	0
RNASE11	122651	broad.mit.edu	37	14	21052296	21052296	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr14:21052296G>A	ENST00000335950.4	-	3	800	c.338C>T	c.(337-339)tCg>tTg	p.S113L	RNASE11_ENST00000555841.1_Missense_Mutation_p.S113L|RNASE11_ENST00000432835.2_Missense_Mutation_p.S113L|RNASE11_ENST00000398009.2_Missense_Mutation_p.S113L|RNASE11_ENST00000398008.2_Missense_Mutation_p.S113L|RNASE11_ENST00000553849.1_Missense_Mutation_p.S113L	NM_145250.3	NP_660293.1	Q8TAA1	RNS11_HUMAN	ribonuclease, RNase A family, 11 (non-active)	113						extracellular region	nucleic acid binding|pancreatic ribonuclease activity			endometrium(1)|large_intestine(6)|lung(7)|ovary(3)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	21	all_cancers(95;0.00238)	all_lung(585;0.235)	Epithelial(56;1.85e-06)|all cancers(55;1.46e-05)	GBM - Glioblastoma multiforme(265;0.0139)		CCACTTGCACGATCCGTTTGC	0.478000													12	34					0	0	1	0	0
SEPT6	23157	broad.mit.edu	37	X	118786864	118786864	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chrX:118786864A>T	ENST00000394610.1	-	4	745	c.481T>A	c.(481-483)Tcc>Acc	p.S161T	SEPT6_ENST00000343984.5_Missense_Mutation_p.S161T|SEPT6_ENST00000354228.4_Missense_Mutation_p.S161T|SEPT6_ENST00000489216.1_Missense_Mutation_p.S161T|SEPT6_ENST00000394617.2_Missense_Mutation_p.S191T|SEPT6_ENST00000354416.3_Missense_Mutation_p.S161T|SEPT6_ENST00000360156.7_Missense_Mutation_p.S161T|SEPT6_ENST00000394616.4_Missense_Mutation_p.S103T	NM_145799.3	NP_665798.1	Q14141	SEPT6_HUMAN	septin 6	161					cell cycle|cytokinesis|interspecies interaction between organisms	cleavage furrow|condensed chromosome kinetochore|midbody|septin complex|spindle	GTP binding|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(3)	17						GACTTCAGGGAATGACCCGTG	0.537000			T	MLL	AML								5	63					0	0	1	0	0
DCTN5	84516	broad.mit.edu	37	16	23672568	23672568	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr16:23672568G>A	ENST00000300087.2	+	4	465	c.314G>A	c.(313-315)gGt>gAt	p.G105D	DCTN5_ENST00000568589.1_Missense_Mutation_p.G105D|DCTN5_ENST00000563998.1_Missense_Mutation_p.G105D	NM_001199743.1|NM_032486.3	NP_001186672.1|NP_115875.1	Q9BTE1	DCTN5_HUMAN	dynactin 5 (p25)	105						centrosome	transferase activity			endometrium(2)|lung(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	10				GBM - Glioblastoma multiforme(48;0.0156)		GCACAGATTGGTTCCTATGTT	0.438000													16	74					0	0	1	0	0
KRT35	3886	broad.mit.edu	37	17	39633390	39633390	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr17:39633390G>A	ENST00000246639.2	-	7	1328	c.1196C>T	c.(1195-1197)gCg>gTg	p.A399V	KRT35_ENST00000393989.1_Missense_Mutation_p.A429V			Q92764	KRT35_HUMAN	keratin 35	429	Coil 2.|Rod.				anatomical structure morphogenesis	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29		Breast(137;0.000286)				GCAGGAGGCCGCAGGAAGACA	0.572000													3	52					0	0	1	0	0
CHCHD7	79145	broad.mit.edu	37	8	57127185	57127185	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr8:57127185A>G	ENST00000523975.1	+	3	197	c.49A>G	c.(49-51)Aca>Gca	p.T17A	CHCHD7_ENST00000396723.5_Missense_Mutation_p.T14A|CHCHD7_ENST00000521831.1_Missense_Mutation_p.T5A|CHCHD7_ENST00000518801.1_Missense_Mutation_p.T17A|CHCHD7_ENST00000517933.1_Missense_Mutation_p.T5A|CHCHD7_ENST00000523061.1_Missense_Mutation_p.T5A|CHCHD7_ENST00000303759.3_Missense_Mutation_p.T30A|CHCHD7_ENST00000519367.1_Missense_Mutation_p.T5A|CHCHD7_ENST00000355315.3_Missense_Mutation_p.T5A|CHCHD7_ENST00000521524.1_Missense_Mutation_p.T17A			Q9BUK0	CHCH7_HUMAN	coiled-coil-helix-coiled-coil-helix domain containing 7	5	CHCH.								CHCHD7/PLAG1(12)	endometrium(1)	1		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00159)|all cancers(17;0.0112)			GCCCTCGGTAACACAGAGGCT	0.368000			T	PLAG1	salivary adenoma								20	21					0	0	1	0	0
HOXB1	3211	broad.mit.edu	37	17	46607102	46607102	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr17:46607102G>A	ENST00000239174.6	-	2	805	c.713C>T	c.(712-714)gCc>gTc	p.A238V	HOXB1_ENST00000577092.1_3'UTR	NM_002144.3	NP_002135.2	P14653	HXB1_HUMAN	homeobox B1	238						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CTCCAGGGTGGCGGCAATCTC	0.577000													17	183					0	0	1	0	0
GNL1	2794	broad.mit.edu	37	6	30522368	30522368	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr6:30522368G>C	ENST00000376621.3	-	5	1554	c.584C>G	c.(583-585)aCt>aGt	p.T195S		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	195					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity			cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						TCGGATATCAGTGATAAGCAG	0.502000													17	102					0	0	1	0	0
UBE2Z	65264	broad.mit.edu	37	17	46988226	46988226	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr17:46988226C>T	ENST00000360943.5	+	2	509	c.374C>T	c.(373-375)aCt>aTt	p.T125I		NM_023079.4	NP_075567.2	Q9H832	UBE2Z_HUMAN	ubiquitin-conjugating enzyme E2Z	125					apoptosis	cytoplasm|nucleus	ATP binding|ubiquitin-protein ligase activity										GTACCTGATACTGTTGACATG	0.463000													9	119					0	0	1	0	0
KCNS3	3790	broad.mit.edu	37	2	18113728	18113728	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:18113728T>A	ENST00000403915.1	+	3	1904	c.1453T>A	c.(1453-1455)Ttg>Atg	p.L485M	KCNS3_ENST00000304101.4_Missense_Mutation_p.L485M|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	485					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					CACCACCTCCTTGGAGAATTG	0.458000													4	55					0	0	1	0	0
PDE5A	8654	broad.mit.edu	37	4	120419812	120419812	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr4:120419812C>G	ENST00000354960.3	-	21	2891	c.2572G>C	c.(2572-2574)Gaa>Caa	p.E858Q	PDE5A_ENST00000264805.5_Missense_Mutation_p.E816Q|RP11-33B1.1_ENST00000498873.1_RNA|PDE5A_ENST00000394439.1_Missense_Mutation_p.E806Q	NM_001083.3	NP_001074.2	O76074	PDE5A_HUMAN	phosphodiesterase 5A, cGMP-specific	858					platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding			breast(4)|endometrium(2)|kidney(3)|large_intestine(8)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	27					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	TCCTGCTGTTCTGCAAGGGCC	0.498000													17	38					0	0	1	0	0
ST5	6764	broad.mit.edu	37	11	8751568	8751568	+	Silent	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr11:8751568G>A	ENST00000534127.1	-	6	1654	c.1269C>T	c.(1267-1269)ccC>ccT	p.P423P	ST5_ENST00000526757.1_Intron|ST5_ENST00000530438.1_Intron|ST5_ENST00000357665.1_Silent_p.P423P|ST5_ENST00000313726.6_Silent_p.P423P	NM_005418.3	NP_005409.3	P78524	ST5_HUMAN	suppression of tumorigenicity 5	423	Interaction with ABL1.|Pro-rich.				positive regulation of ERK1 and ERK2 cascade		protein binding			NS(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(13)|liver(1)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	39				Epithelial(150;2.63e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0352)		CTGGGGTGGAGGGCAAGGGAG	0.597000													17	172					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230902171	230902171	+	Silent	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:230902171G>A	ENST00000295190.4	-	5	1916	c.1458C>T	c.(1456-1458)ctC>ctT	p.L486L		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	486						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TAAGTAAAAAGAGTATTCCTA	0.328000													12	13					0	0	1	0	0
GABRG3	2567	broad.mit.edu	37	15	27777805	27777805	+	Silent	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr15:27777805C>T	ENST00000333743.6	+	10	1436	c.1182C>T	c.(1180-1182)tcC>tcT	p.S394S	RP11-100M12.3_ENST00000556642.1_RNA	NM_033223.4	NP_150092.2	Q99928	GBRG3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 3	394					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(23)|skin(1)|upper_aerodigestive_tract(4)	42		all_lung(180;4.58e-12)|Breast(32;0.000625)|Colorectal(260;0.235)		all cancers(64;3.15e-07)|Epithelial(43;1.17e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0261)		TAAACAATTCCGTTTACTGGC	0.423000													3	16					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22958262	22958262	+	Silent	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr15:22958262G>A	ENST00000313077.7	+	17	2030	c.1905G>A	c.(1903-1905)agG>agA	p.R635R	CYFIP1_ENST00000560848.1_Silent_p.R635R|CYFIP1_ENST00000435939.2_Silent_p.R204R	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	635					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TGGGCAGGAGGATCCAGTTCC	0.577000													4	26					0	0	1	0	0
COG2	22796	broad.mit.edu	37	1	230822799	230822799	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr1:230822799C>T	ENST00000534989.1	+	13	1657	c.1322C>T	c.(1321-1323)tCg>tTg	p.S441L	COG2_ENST00000366669.4_Missense_Mutation_p.S500L|COG2_ENST00000535166.1_Missense_Mutation_p.S384L|COG2_ENST00000366668.3_Missense_Mutation_p.S500L|COG2_ENST00000546013.1_Missense_Mutation_p.S189L			Q14746	COG2_HUMAN	component of oligomeric golgi complex 2	500					Golgi organization|intra-Golgi vesicle-mediated transport|intracellular protein transport|oligosaccharide biosynthetic process|protein glycosylation	Golgi membrane|Golgi stack|Golgi transport complex	protein binding|protein transporter activity			NS(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(11)|prostate(2)|skin(2)|urinary_tract(3)	27	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)				AGTGGTCCTTCGGAAACAAAG	0.483000													4	29					0	0	1	0	0
TAOK3	51347	broad.mit.edu	37	12	118610379	118610379	+	Silent	SNP	A	A	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr12:118610379A>T	ENST00000392533.3	-	17	2272	c.1782T>A	c.(1780-1782)gcT>gcA	p.A594A	TAOK3_ENST00000537952.1_Silent_p.A134A|TAOK3_ENST00000419821.2_Silent_p.A594A	NM_016281.3	NP_057365.3	Q9H2K8	TAOK3_HUMAN	TAO kinase 3	594					MAPKKK cascade|negative regulation of JNK cascade|positive regulation of JNK cascade|protein autophosphorylation	mitochondrion|plasma membrane	ATP binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			central_nervous_system(1)|lung(5)|skin(1)	7	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CTTCCTCTTCAGCCTGTGTGT	0.453000													5	99					0	0	1	0	0
UNC5C	8633	broad.mit.edu	37	4	96127880	96127880	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr4:96127880G>A	ENST00000453304.1	-	11	2149	c.1801C>T	c.(1801-1803)Ctc>Ttc	p.L601F		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	601	ZU5.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GGGCGGGTGAGCAGAGCTCCT	0.577000													5	23					0	0	1	0	0
CASKIN1	57524	broad.mit.edu	37	16	2233719	2233719	+	Silent	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr16:2233719C>T	ENST00000343516.6	-	16	1649	c.1557G>A	c.(1555-1557)ccG>ccA	p.P519P	CASKIN1_ENST00000564289.1_Intron	NM_020764.3	NP_065815.1	Q8WXD9	CSKI1_HUMAN	CASK interacting protein 1	519	SAM 1.				signal transduction	cytoplasm				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|liver(1)|lung(7)|ovary(4)|prostate(5)|skin(3)	28						TCCGGTGGCCCGGCTTGGTGA	0.662000													5	40					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66637828	66637828	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr11:66637828A>G	ENST00000393960.1	-	9	1129	c.848T>C	c.(847-849)cTg>cCg	p.L283P	PC_ENST00000524491.1_Missense_Mutation_p.L243P|PC_ENST00000393955.2_Missense_Mutation_p.L283P|PC_ENST00000393958.2_Missense_Mutation_p.L283P|PC_ENST00000355677.3_Missense_Mutation_p.L283P	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	283	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CTGCGGGTCCAGGTGGGCGGC	0.632000													18	38					0	0	1	0	0
SLAMF9	89886	broad.mit.edu	37	1	159923408	159923408	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr1:159923408C>T	ENST00000368093.3	-	2	198	c.82G>A	c.(82-84)Gag>Aag	p.E28K	SLAMF9_ENST00000368092.3_Missense_Mutation_p.E28K	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	28						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ACCACTTCCTCGGATCCACAC	0.527000													4	62					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72143660	72143660	+	Missense_Mutation	SNP	G	G	A	rs151292865		TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr15:72143660G>A	ENST00000356056.5	-	37	6987	c.6515C>T	c.(6514-6516)tCt>tTt	p.S2172F	MYO9A_ENST00000444904.1_Missense_Mutation_p.S2153F|MYO9A_ENST00000564571.1_Missense_Mutation_p.S2172F|MYO9A_ENST00000424560.1_Missense_Mutation_p.S2243F	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	2172	Rho-GAP.|Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						ATCAATCACAGAGTATACACC	0.408000													17	36					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115828996	115828996	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr1:115828996C>T	ENST00000369512.2	-	3	589	c.421G>A	c.(421-423)Gtg>Atg	p.V141M	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	141					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	CCAACCCACACGCTGACACTG	0.537000													20	55					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129786365	129786365	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr6:129786365G>A	ENST00000421865.2	+	51	7280	c.7231G>A	c.(7231-7233)Gtt>Att	p.V2411I		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2411	Laminin G-like 2.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AATGGCTTCCGTTGTCAGCAA	0.383000													9	37					0	0	1	0	0
BRAT1	221927	broad.mit.edu	37	7	2578938	2578938	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr7:2578938G>C	ENST00000340611.4	-	13	1901	c.1645C>G	c.(1645-1647)Ctg>Gtg	p.L549V	BRAT1_ENST00000473879.1_Intron	NM_152743.3	NP_689956.2	Q6PJG6	BRAT1_HUMAN	BRCA1-associated ATM activator 1	549					response to ionizing radiation	nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	23						TGCAGGGCCAGCTGAGGCACC	0.652000													9	13					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378530	114378530	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr6:114378530C>T	ENST00000312719.5	-	5	2120	c.932G>A	c.(931-933)cGc>cAc	p.R311H	RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|HS3ST5_ENST00000411826.1_Missense_Mutation_p.R311H|RP3-399L15.3_ENST00000519104.1_RNA			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	311					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding	p.R311H(1)		breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TGGATGAATGCGCCCCTTGCT	0.403000													8	47					0	0	1	0	0
CDYL2	124359	broad.mit.edu	37	16	80718918	80718918	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr16:80718918G>A	ENST00000299564.8	-	2	288	c.133C>T	c.(133-135)Ctc>Ttc	p.L45F	CDYL2_ENST00000563890.1_Missense_Mutation_p.L45F|CDYL2_ENST00000562812.1_Missense_Mutation_p.L45F|CDYL2_ENST00000562753.1_5'UTR|CDYL2_ENST00000566173.1_Missense_Mutation_p.L45F	NM_152342.2	NP_689555.2	Q8N8U2	CDYL2_HUMAN	chromodomain protein, Y-like 2	45	Chromo.					nucleus	catalytic activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	21						CAGTGCAAGAGGTGGTGCTCC	0.498000													8	66					0	0	1	0	0
TRAV38-1	28644	broad.mit.edu	37	14	22740419	22740419	+	RNA	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr14:22740419C>T	ENST00000390464.2	+	0	326																											GGGGACACTGCGATGTATTTC	0.483000													4	26					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13522908	13522908	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr10:13522908C>A	ENST00000341083.3	-	6	1194	c.898G>T	c.(898-900)Gca>Tca	p.A300S	BEND7_ENST00000396900.2_Missense_Mutation_p.A352S|BEND7_ENST00000396898.2_Missense_Mutation_p.A365S|BEND7_ENST00000378605.3_Missense_Mutation_p.A313S	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	352	BEN.						protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						CCTTTTATTGCACCCACAATA	0.413000													4	39					0.000602214	0.000620744	1	1	0
UBE3A	7337	broad.mit.edu	37	15	25602039	25602039	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr15:25602039C>T	ENST00000232165.3	-	8	2414	c.1758G>A	c.(1756-1758)atG>atA	p.M586I	UBE3A_ENST00000438097.1_Missense_Mutation_p.M566I|UBE3A_ENST00000428984.2_Missense_Mutation_p.M566I|UBE3A_ENST00000397954.2_Missense_Mutation_p.M589I|UBE3A_ENST00000566215.1_Missense_Mutation_p.M566I|SNHG14_ENST00000554726.1_RNA	NM_000462.3|NM_130839.2	NP_000453.2|NP_570854.1	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A	589					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(13)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	38		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		CGTATGTGAACATACCTATAA	0.269000													5	43					0	0	1	0	0
MSH6	2956	broad.mit.edu	37	2	48027676	48027678	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:48027676_48027678delAAG	ENST00000234420.4	+	4	2706_2708	c.2554_2556delAAG	c.(2554-2556)del	p.K854del	FBXO11_ENST00000405808.1_Intron|MSH6_ENST00000540021.1_In_Frame_Del_p.K724del|MSH6_ENST00000538136.1_In_Frame_Del_p.K552del	NM_000179.2	NP_000170.1	P52701	MSH6_HUMAN	mutS homolog 6	854			K -> M (in CRC; could be a polymorphism; dbSNP:rs34374438).		determination of adult lifespan|DNA damage response, signal transduction resulting in induction of apoptosis|isotype switching|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|response to UV|somatic hypermutation of immunoglobulin genes	MutSalpha complex	ATP binding|DNA-dependent ATPase activity|protein binding	p.0?(2)		breast(8)|central_nervous_system(29)|cervix(1)|endometrium(32)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(75)|lung(25)|ovary(3)|prostate(3)|skin(10)|stomach(22)|thyroid(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	229		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TACATACAGCAAGAAGAAGATTA	0.374			"""Mis, N, F, S"""		colorectal	"""colorectal, endometrial, ovarian"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				9	41	---	---	---	---					
AC012363.13	0	broad.mit.edu	37	2	121080891	121080893	+	RNA	DEL	CCT	CCT	-	rs138298647	by1000genomes	TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:121080891_121080893delCCT	ENST00000437837.1	+	0	132																											CTGCCTCCCCCCTCCTCCTCCTC	0.542													2	4	---	---	---	---					
SUMO1	7341	broad.mit.edu	37	2	203072040	203072040	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr2:203072040delC	ENST00000392246.2	-	5	398	c.242delG	c.(241-243)gafs	p.G81fs	SUMO1_ENST00000392245.1_Frame_Shift_Del_p.G81fs|SUMO1_ENST00000409205.1_Frame_Shift_Del_p.G42fs|SUMO1_ENST00000409181.1_3'UTR|SUMO1_ENST00000409368.1_Frame_Shift_Del_p.G126fs|SUMO1_ENST00000409498.2_Frame_Shift_Del_p.G42fs|SUMO1_ENST00000392244.3_Frame_Shift_Del_p.G56fs|SUMO1_ENST00000409712.1_Frame_Shift_Del_p.G57fs|SUMO1_ENST00000469034.1_5'UTR	NM_003352.4	NP_003343.1	P63165	SUMO1_HUMAN	small ubiquitin-like modifier 1	81	Ubiquitin-like.				DNA repair|interferon-gamma-mediated signaling pathway|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|palate development|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein complex assembly|protein sumoylation|regulation of interferon-gamma-mediated signaling pathway|regulation of protein localization	cytoplasm|nuclear membrane|nuclear pore|nuclear speck	ubiquitin protein ligase binding										TTCCTCCATTCCCAGCTGTAA	0.333													31	239	---	---	---	---					
NISCH	11188	broad.mit.edu	37	3	52526377	52526377	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr3:52526377delG	ENST00000345716.4	+	21	4528	c.4394delG	c.(4393-4395)ctfs	p.R1465fs	NISCH_ENST00000479054.1_Frame_Shift_Del_p.R1465fs	NM_007184.3	NP_009115.2	Q9Y2I1	NISCH_HUMAN	nischarin	1465					apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	33				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		AGCCAGGGCCGTGAAGTCCAG	0.627													60	75	---	---	---	---					
PTDSS2	81490	broad.mit.edu	37	11	490555	490555	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr11:490555delG	ENST00000308020.5	+	12	1613	c.1437delG	c.(1435-1437)gafs	p.E479fs		NM_030783.1	NP_110410.1	Q9BVG9	PTSS2_HUMAN	phosphatidylserine synthase 2	479						integral to membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|skin(1)	9		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;2.76e-26)|Epithelial(43;2.56e-25)|OV - Ovarian serous cystadenocarcinoma(40;7.54e-20)|BRCA - Breast invasive adenocarcinoma(625;8.76e-05)|Lung(200;0.0407)|LUSC - Lung squamous cell carcinoma(625;0.0735)	Phosphatidylserine(DB00144)	GGGTGGCCGAGGGCGAGGGAG	0.677													2	4	---	---	---	---					
CD79A	973	broad.mit.edu	37	19	42384773	42384773	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr19:42384773delG	ENST00000221972.3	+	4	720	c.535delG	c.(535-537)ggfs	p.G179fs	CD79A_ENST00000444740.2_Frame_Shift_Del_p.G141fs	NM_001783.3|NM_021601.3	NP_001774.1|NP_067612.1	P11912	CD79A_HUMAN	CD79a molecule, immunoglobulin-associated alpha	179	ITAM.				B cell differentiation|B cell proliferation|B cell receptor signaling pathway	B cell receptor complex|external side of plasma membrane|integral to membrane|membrane raft|multivesicular body	transmembrane receptor activity			large_intestine(3)|lung(3)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11						GTTGGATGCCGGGGATGAATA	0.567			"""O, S"""		DLBCL								2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11094127	11094128	+	RNA	INS	-	-	T	rs142937341		TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr21:11094127_11094128insT	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGCACAGTGTGTTTTTTTCCAC	0.292													3	6	---	---	---	---					
P2RX6	9127	broad.mit.edu	37	22	21380547	21380547	+	Frame_Shift_Del	DEL	T	T	-			TCGA-86-8075-01A-11D-2238-08	TCGA-86-8075-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	edc1d956-747a-41fe-b825-f07486629b65	bef25d55-1f0d-4c42-8771-88c84a639583	g.chr22:21380547delT	ENST00000413302.2	+	11	1205	c.1057delT	c.(1057-1059)ttfs	p.F354fs	P2RX6_ENST00000443995.3_Frame_Shift_Del_p.F301fs|P2RX6_ENST00000401443.1_Frame_Shift_Del_p.F328fs|P2RX6_ENST00000336296.2_Frame_Shift_Del_p.F344fs|P2RX6_ENST00000402329.3_3'UTR			O15547	P2RX6_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 6	354					muscle contraction|protein homooligomerization	cell junction|cytoplasm|integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|identical protein binding|purinergic nucleotide receptor activity										CCAGGTCACCTTTTTCTGTGA	0.587													2	4	---	---	---	---					
