Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KCNS3	3790	broad.mit.edu	37	2	18112940	18112940	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr2:18112940T>C	ENST00000403915.1	+	3	1116	c.665T>C	c.(664-666)cTg>cCg	p.L222P	KCNS3_ENST00000304101.4_Missense_Mutation_p.L222P|KCNS3_ENST00000465292.1_Intron			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	222					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GATCCGGTGCTGGAAGGAGTG	0.572000													5	69					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176295217	176295217	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr5:176295217G>A	ENST00000329542.4	+	3	653	c.379G>A	c.(379-381)Gtg>Atg	p.V127M	UNC5A_ENST00000261961.3_Missense_Mutation_p.V87M	NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)	127	Ig-like.				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGCCAGTGCGTGGCATGGAG	0.652000													6	107					0	0	1	0	0
RASL10B	91608	broad.mit.edu	37	17	34068232	34068232	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr17:34068232C>A	ENST00000268864.3	+	4	897	c.520C>A	c.(520-522)Ctc>Atc	p.L174I		NM_033315.3	NP_201572.1	Q96S79	RSLAB_HUMAN	RAS-like, family 10, member B	174	Small GTPase-like.				small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			breast(2)|endometrium(2)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		CAGCGAGCTGCTCAAGAGCGT	0.652000													10	20					7.48243e-07	8.13878e-07	1	1	0
BMP2K	55589	broad.mit.edu	37	4	79792085	79792085	+	Missense_Mutation	SNP	G	G	C	rs71828885		TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr4:79792085G>C	ENST00000335016.5	+	11	1546	c.1380G>C	c.(1378-1380)caG>caC	p.Q460H	BMP2K_ENST00000502871.1_Missense_Mutation_p.Q460H	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	460	Gln/His-rich.					nucleus	ATP binding|protein serine/threonine kinase activity	p.Q460H(3)		NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						ATCCTCACcagcagcagcagc	0.577000													3	40					0	0	1	0	0
ARHGAP9	64333	broad.mit.edu	37	12	57872994	57872994	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr12:57872994G>A	ENST00000393797.2	-	5	601	c.409C>T	c.(409-411)Cgc>Tgc	p.R137C	ARHGAP9_ENST00000424809.2_Missense_Mutation_p.R66C|ARHGAP9_ENST00000550288.1_Missense_Mutation_p.R145C|ARHGAP9_ENST00000356411.2_Missense_Mutation_p.R66C|ARHGAP9_ENST00000393791.3_Missense_Mutation_p.R66C			Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9	66			R -> C (in dbSNP:rs3802989).		regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			endometrium(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(1)	30			GBM - Glioblastoma multiforme(3;3.37e-34)			GCTTCTAGGCGTCTTGCCAAC	0.552000													30	70					0	0	1	0	0
STAMBP	10617	broad.mit.edu	37	2	74058069	74058069	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr2:74058069A>C	ENST00000394070.2	+	2	589	c.86A>C	c.(85-87)gAa>gCa	p.E29A	STAMBP_ENST00000536064.1_Missense_Mutation_p.E29A|STAMBP_ENST00000409707.1_Missense_Mutation_p.E29A|STAMBP_ENST00000339566.3_Missense_Mutation_p.E29A|STAMBP_ENST00000394073.1_Missense_Mutation_p.E29A	NM_213622.2	NP_998787.1	O95630	STABP_HUMAN	STAM binding protein	29	Interaction with CHMP3.				JAK-STAT cascade|positive regulation of cell proliferation	early endosome|membrane|nucleus	metal ion binding|metallopeptidase activity|protein binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	18						GAGGTGAATGAAGACATTCCA	0.542000													24	41					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35966468	35966468	+	Silent	SNP	C	C	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chrX:35966468C>T	ENST00000297866.5	+	4	621	c.555C>T	c.(553-555)atC>atT	p.I185I		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	185										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						AATTACCCATCCTCATTTTTC	0.403000													5	115					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000455089.1_Missense_Mutation_p.L813R|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			27	144					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95372626	95372626	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr10:95372626G>T	ENST00000371447.3	+	1	282	c.144G>T	c.(142-144)atG>atT	p.M48I		NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	48					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				AGTCCAGCATGTCCTTCTCTG	0.592000													29	60					0.000279167	0.000293362	1	1	0
TENM2	57451	broad.mit.edu	37	5	167673885	167673885	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr5:167673885G>A	ENST00000519204.1	+	26	5696	c.5578G>A	c.(5578-5580)Ggc>Agc	p.G1860S	TENM2_ENST00000520394.1_Missense_Mutation_p.G1742S|TENM2_ENST00000545108.1_Missense_Mutation_p.G1980S|TENM2_ENST00000403607.2_Missense_Mutation_p.G1805S|TENM2_ENST00000518659.1_Missense_Mutation_p.G1981S					teneurin transmembrane protein 2																		CACCTCCATCGGCTACATCCG	0.532000													45	107					0	0	1	0	0
HOXA3	3200	broad.mit.edu	37	7	27148128	27148128	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr7:27148128G>T	ENST00000396352.4	-	3	937	c.738C>A	c.(736-738)taC>taA	p.Y246*	HOXA3_ENST00000317201.2_Nonsense_Mutation_p.Y246*|HOXA-AS2_ENST00000518088.1_RNA	NM_030661.4	NP_109377.1	O43365	HXA3_HUMAN	homeobox A3	246					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|lung(18)|skin(1)	29						GATCCTTTTTGTACTTCATGC	0.607000													32	142					2.81731e-10	3.11917e-10	1	1	0
SOX11	6664	broad.mit.edu	37	2	5833205	5833205	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr2:5833205T>A	ENST00000322002.3	+	1	407	c.352T>A	c.(352-354)Tac>Aac	p.Y118N		NM_003108.3	NP_003099.1	P35716	SOX11_HUMAN	SRY (sex determining region Y)-box 11	118					cardiac ventricle formation|closure of optic fissure|cornea development in camera-type eye|embryonic digestive tract morphogenesis|embryonic skeletal system morphogenesis|eyelid development in camera-type eye|glial cell proliferation|hard palate development|lens morphogenesis in camera-type eye|limb bud formation|lung morphogenesis|negative regulation of cell death|negative regulation of glial cell proliferation|negative regulation of lymphocyte proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription regulatory region DNA binding|neural crest cell development|neural tube formation|neuroepithelial cell differentiation|noradrenergic neuron differentiation|outflow tract morphogenesis|positive regulation of BMP signaling pathway|positive regulation of hippo signaling cascade|positive regulation of hormone secretion|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of ossification|positive regulation of osteoblast differentiation|positive regulation of stem cell proliferation|regulation of transforming growth factor beta receptor signaling pathway|signal transduction involved in G1/S transition checkpoint|soft palate development|somite development|spinal cord development|sympathetic nervous system development|ventricular septum morphogenesis	cytoplasm|nucleolus	enhancer sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|RNA polymerase II transcription coactivator activity|translation factor activity, nucleic acid binding			central_nervous_system(5)|cervix(1)|endometrium(1)|liver(1)|lung(4)|stomach(1)	13	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			OV - Ovarian serous cystadenocarcinoma(76;0.132)		CGACTACAAGTACCGGCCCCG	0.677000													6	20					0	0	1	0	0
USP51	158880	broad.mit.edu	37	X	55514404	55514404	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chrX:55514404C>G	ENST00000500968.3	-	2	1051	c.969G>C	c.(967-969)caG>caC	p.Q323H	USP51_ENST00000586165.1_Splice_Site	NM_201286.3	NP_958443.1	Q70EK9	UBP51_HUMAN	ubiquitin specific peptidase 51	323					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30						ATGTCATAAACTGTTGATGAG	0.343000													39	94					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18721542	18721542	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr9:18721542G>T	ENST00000380548.4	+	15	2224	c.1885G>T	c.(1885-1887)Gag>Tag	p.E629*	ADAMTSL1_ENST00000276935.6_Nonsense_Mutation_p.E629*	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	629	TSP type-1 5.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		AGGTGTCCAGGAGGCTGTGGT	0.597000													4	87					0.184627	0.184627	1	1	0
RFC1	5981	broad.mit.edu	37	4	39310627	39310627	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr4:39310627C>T	ENST00000381897.1	-	13	1647	c.1514G>A	c.(1513-1515)aGa>aAa	p.R505K	RFC1_ENST00000349703.2_Missense_Mutation_p.R505K	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	505					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						TTGGGGTGTTCTCTCCAGTTT	0.363000													4	82					0	0	1	0	0
AGPAT3	56894	broad.mit.edu	37	21	45390580	45390580	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr21:45390580G>A	ENST00000398063.2	+	5	1049	c.557G>A	c.(556-558)cGc>cAc	p.R186H	AGPAT3_ENST00000546158.1_Missense_Mutation_p.R186H|AGPAT3_ENST00000398061.1_Missense_Mutation_p.R186H|AGPAT3_ENST00000479117.1_3'UTR|AGPAT3_ENST00000327505.2_Missense_Mutation_p.R186H|AGPAT3_ENST00000398058.1_Missense_Mutation_p.R186H|AGPAT3_ENST00000291572.8_Missense_Mutation_p.R186H	NM_001037553.1	NP_001032642.1	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	186					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			large_intestine(4)|lung(5)|ovary(1)|prostate(1)	11				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		ACCAAGCACCGCGTTAGCATG	0.622000													3	40					0	0	1	0	0
AGAP1	116987	broad.mit.edu	37	2	236626256	236626256	+	Missense_Mutation	SNP	C	C	T	rs145578290		TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr2:236626256C>T	ENST00000409538.1	+	3	1569	c.1073C>T	c.(1072-1074)aCg>aTg	p.T358M	AGAP1_ENST00000304032.7_Missense_Mutation_p.T93M|AGAP1_ENST00000409457.1_Missense_Mutation_p.T93M|AGAP1_ENST00000336665.5_Missense_Mutation_p.T93M			Q9UPQ3	AGAP1_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	93	PH.				protein transport|regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm	ARF GTPase activator activity|GTP binding|zinc ion binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						CGGTACCTGACGGGCACATAT	0.458000													5	36					0	0	1	0	0
PRSS16	10279	broad.mit.edu	37	6	27216959	27216959	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr6:27216959G>A	ENST00000230582.3	+	4	433	c.418G>A	c.(418-420)Gct>Act	p.A140T	PRSS16_ENST00000421826.2_Intron	NM_005865.3	NP_005856.1	Q9NQE7	TSSP_HUMAN	protease, serine, 16 (thymus)	140					protein catabolic process|proteolysis	cytoplasmic membrane-bounded vesicle	serine-type peptidase activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	26						GAGTATACCTGCTGGAGGCCT	0.572000													21	52					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435441	158435441	+	Silent	SNP	C	C	T	rs147936310	byFrequency	TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr1:158435441C>T	ENST00000289451.2	+	1	170	c.90C>T	c.(88-90)atC>atT	p.I30I		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					TCTTTGTTATCTTCCTGCTCC	0.512000													10	57					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25255331	25255331	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr16:25255331G>A	ENST00000328086.7	-	6	2559	c.1756C>T	c.(1756-1758)Cgg>Tgg	p.R586W		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	586					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		GCAGATGCCCGAGAGTTAATC	0.532000													26	127					0	0	1	0	0
FAM3D	131177	broad.mit.edu	37	3	58639410	58639410	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr3:58639410G>A	ENST00000358781.2	-	3	422	c.112C>T	c.(112-114)Cgc>Tgc	p.R38C		NM_138805.2	NP_620160.1	Q96BQ1	FAM3D_HUMAN	family with sequence similarity 3, member D	38					negative regulation of insulin secretion	extracellular region	cytokine activity			large_intestine(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(55;0.000225)|Kidney(10;0.000667)|KIRC - Kidney renal clear cell carcinoma(10;0.000802)|OV - Ovarian serous cystadenocarcinoma(275;0.169)		CCCAGCCAGCGTGGCAGACGG	0.572000													31	91					0	0	1	0	0
TBX6	6911	broad.mit.edu	37	16	30100028	30100028	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr16:30100028A>T	ENST00000553607.1	-	4	1447	c.754T>A	c.(754-756)Tac>Aac	p.Y252N	TBX6_ENST00000279386.2_Missense_Mutation_p.Y252N|TBX6_ENST00000395224.2_Missense_Mutation_p.Y252N			O95947	TBX6_HUMAN	T-box 6	252					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						GGGTTCTGGTAGGCTGTCACG	0.627000													100	194					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	4006999	4006999	+	Silent	SNP	C	C	T	rs149234557		TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr7:4006999C>T	ENST00000404826.2	+	10	1618	c.1479C>T	c.(1477-1479)gaC>gaT	p.D493D	SDK1_ENST00000389531.3_Silent_p.D493D	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	493	Ig-like C2-type 5.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		CAGTTACTGACGGGATGACAG	0.552000													26	142					0	0	1	0	0
ENGASE	64772	broad.mit.edu	37	17	77076422	77076422	+	Silent	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr17:77076422G>A	ENST00000579016.1	+	5	699	c.699G>A	c.(697-699)ctG>ctA	p.L233L	ENGASE_ENST00000539857.2_Silent_p.L47L	NM_001042573.2	NP_001036038.1	Q8NFI3	ENASE_HUMAN	endo-beta-N-acetylglucosaminidase	233						cytosol	mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity			breast(2)|endometrium(4)|large_intestine(1)|lung(15)|prostate(2)|skin(1)	25						ATGGCTGGCTGATCAACATCG	0.612000													5	67					0	0	1	0	0
FAM107A	11170	broad.mit.edu	37	3	58552369	58552369	+	Silent	SNP	G	G	C			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr3:58552369G>C	ENST00000394481.1	-	5	939	c.381C>G	c.(379-381)gtC>gtG	p.V127V	FAM107A_ENST00000447756.2_Silent_p.V155V|FAM107A_ENST00000464064.1_3'UTR|FAM107A_ENST00000360997.2_Silent_p.V127V|FAM107A_ENST00000474531.1_Silent_p.V158V	NM_007177.2	NP_009108.1	O95990	F107A_HUMAN	family with sequence similarity 107, member A	127					regulation of cell growth	nucleus	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	13				BRCA - Breast invasive adenocarcinoma(55;0.000189)|Kidney(10;0.000536)|KIRC - Kidney renal clear cell carcinoma(10;0.000716)|OV - Ovarian serous cystadenocarcinoma(275;0.154)		GGTTTTCCCTGACTTTAATAA	0.582000													24	45					0	0	1	0	0
LYN	4067	broad.mit.edu	37	8	56866463	56866463	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr8:56866463A>T	ENST00000520220.2	+	8	921	c.647A>T	c.(646-648)aAa>aTa	p.K216I	LYN_ENST00000519728.1_Missense_Mutation_p.K237I	NM_001111097.2	NP_001104567.1	P07948	LYN_HUMAN	v-yes-1 Yamaguchi sarcoma viral related oncogene homolog	237	SH2.				erythrocyte differentiation|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of cellular component movement|positive regulation of stress-activated protein kinase signaling cascade|positive regulation of tyrosine phosphorylation of STAT protein|response to DNA damage stimulus|T cell costimulation	cytosol|Golgi apparatus|membrane raft|nucleus|perinuclear region of cytoplasm	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|receptor signaling protein tyrosine kinase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	22		all_lung(136;0.0555)|Lung NSC(129;0.0726)|all_epithelial(80;0.0772)	Epithelial(17;0.000834)|all cancers(17;0.00598)			CCATGGGATAAAGATGCCTGG	0.517000													4	64					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37975908	37975908	+	Nonsense_Mutation	SNP	C	C	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr19:37975908C>T	ENST00000330173.1	+	5	1913	c.1384C>T	c.(1384-1386)Cga>Tga	p.R462*	ZNF570_ENST00000388801.3_Nonsense_Mutation_p.R259*|ZNF570_ENST00000586475.1_Nonsense_Mutation_p.R518*	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCAACATCAGCGAGTTCATAC	0.423000													17	92					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640521	104640521	+	Silent	SNP	G	G	C			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr4:104640521G>C	ENST00000304883.2	-	1	452	c.312C>G	c.(310-312)ctC>ctG	p.L104L		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	104						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		AGATGACGATGAGATTTCCCA	0.592000													26	53					0	0	1	0	0
LRRC66	339977	broad.mit.edu	37	4	52861242	52861242	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr4:52861242A>T	ENST00000343457.3	-	4	1952	c.1946T>A	c.(1945-1947)cTt>cAt	p.L649H		NM_001024611.1	NP_001019782.1	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	649						integral to membrane				central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(8)|lung(34)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	58						GTGGGCTGAAAGCGCTTCCTC	0.537000													18	37					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67053973	67053973	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr3:67053973C>A	ENST00000295568.4	+	3	635	c.504C>A	c.(502-504)gaC>gaA	p.D168E	KBTBD8_ENST00000460576.1_Intron|KBTBD8_ENST00000469661.1_3'UTR|KBTBD8_ENST00000417314.2_Missense_Mutation_p.D194E	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	194	BACK.									breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		TGACAAAAGACCAACTGATAA	0.363000													20	55					3.51602e-12	3.96351e-12	1	1	0
TMEM92	162461	broad.mit.edu	37	17	48355986	48355986	+	Silent	SNP	C	C	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr17:48355986C>T	ENST00000300433.3	+	4	275	c.165C>T	c.(163-165)ccC>ccT	p.P55P	TMEM92_ENST00000511882.1_3'UTR|TMEM92_ENST00000507382.1_Silent_p.P55P	NM_001168215.1	NP_001161687.1	Q6UXU6	TMM92_HUMAN	transmembrane protein 92	55						integral to membrane				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(1)	7						TCCCTGGCCCCGTGAGGTGAG	0.642000													3	42					0	0	1	0	0
ADSSL1	122622	broad.mit.edu	37	14	105208279	105208279	+	Silent	SNP	C	C	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr14:105208279C>T	ENST00000332972.5	+	9	1176	c.1017C>T	c.(1015-1017)ggC>ggT	p.G339G	ADSSL1_ENST00000330877.2_Silent_p.G296G	NM_199165.1	NP_954634.1	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1	296					AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			central_nervous_system(1)|cervix(1)|kidney(1)|lung(5)|ovary(2)|prostate(1)	11		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	ACGTGTATGGCGTGGTGAAAG	0.637000													12	123					0	0	1	0	0
TMEM43	79188	broad.mit.edu	37	3	14183248	14183248	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr3:14183248C>T	ENST00000306077.4	+	12	1410	c.1156C>T	c.(1156-1158)Ccc>Tcc	p.P386S	RP11-434D12.1_ENST00000601399.1_RNA	NM_024334.2	NP_077310.1	Q9BTV4	TMM43_HUMAN	transmembrane protein 43	386						endoplasmic reticulum|Golgi apparatus|integral to membrane|nuclear inner membrane				breast(1)|cervix(3)|endometrium(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(2)	19						GGCCCTTGTGCCCATCCTTGT	0.647000													3	46					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141299352	141299352	+	Silent	SNP	A	A	G			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr2:141299352A>G	ENST00000389484.3	-	44	8354	c.7383T>C	c.(7381-7383)aaT>aaC	p.N2461N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2461					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTTACAGCTATTGGTGTCAT	0.343000										TSP Lung(27;0.18)			18	66					0	0	1	0	0
SDF2	6388	broad.mit.edu	37	17	26982376	26982376	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr17:26982376G>A	ENST00000247020.4	-	2	575	c.277C>T	c.(277-279)Cgg>Tgg	p.R93W	SDF2_ENST00000592250.1_5'UTR	NM_006923.3	NP_008854.2	Q99470	SDF2_HUMAN	stromal cell-derived factor 2	93	MIR 2.				protein glycosylation	extracellular space|membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(2)	7	Lung NSC(42;0.00431)					TGTGTCAGCCGGATGGGCTGG	0.537000													26	112					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52159617	52159617	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr12:52159617G>A	ENST00000354534.5	+	16	2885	c.2707G>A	c.(2707-2709)Gag>Aag	p.E903K	SCN8A_ENST00000550891.1_Missense_Mutation_p.E903K|SCN8A_ENST00000545061.1_Missense_Mutation_p.E903K	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	903					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	AAGCTACAAAGAGTGTGTCTG	0.493000													31	37					0	0	1	0	0
ST13	6767	broad.mit.edu	37	22	41244358	41244358	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr22:41244358T>A	ENST00000216218.3	-	3	665	c.184A>T	c.(184-186)Agt>Tgt	p.S62C		NM_003932.3	NP_003923.2	P50502	F10A1_HUMAN	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	62							protein binding, bridging			cervix(1)|large_intestine(1)|lung(3)|skin(1)	6						ACCTTCTTACTATCAGGTTTT	0.348000													4	29					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44561400	44561400	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr7:44561400T>C	ENST00000289547.4	-	12	2919	c.2864A>G	c.(2863-2865)gAt>gGt	p.D955G	NPC1L1_ENST00000546276.1_Missense_Mutation_p.D909G|NPC1L1_ENST00000381160.3_Missense_Mutation_p.D955G	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	955					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	AATGAAGTCATCCACCCAGGA	0.602000													7	63					0	0	1	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26666553	26666553	+	Silent	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr17:26666553G>A	ENST00000226225.2	+	2	273	c.6G>A	c.(4-6)tcG>tcA	p.S2S	TNFAIP1_ENST00000583213.1_Intron|TNFAIP1_ENST00000544907.2_Intron	NM_021137.4	NP_066960.1	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1 (endothelial)	2					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	12	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		GGGAGATGTCGGGGGACACCT	0.637000													4	38					0	0	1	0	0
FGFR4	2264	broad.mit.edu	37	5	176518693	176518693	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr5:176518693A>C	ENST00000292408.4	+	6	856	c.611A>C	c.(610-612)cAt>cCt	p.H204P	FGFR4_ENST00000502906.1_Missense_Mutation_p.H204P|FGFR4_ENST00000393648.2_Missense_Mutation_p.H204P|FGFR4_ENST00000393637.1_Missense_Mutation_p.H204P|FGFR4_ENST00000292410.3_Missense_Mutation_p.H204P	NM_002011.3|NM_213647.1	NP_002002.3|NP_998812.1	P22455	FGFR4_HUMAN	fibroblast growth factor receptor 4	204	Ig-like C2-type 2.				insulin receptor signaling pathway|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	34	all_cancers(89;5.93e-05)|Renal(175;0.000269)|Lung NSC(126;0.0088)|all_lung(126;0.0142)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Palifermin(DB00039)	CAGCTGCGCCATCAGCACTGG	0.632000										TSP Lung(9;0.080)			3	36					0	0	1	0	0
PCBP3	54039	broad.mit.edu	37	21	47333995	47333995	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr21:47333995A>C	ENST00000400304.1	+	7	635	c.635A>C	c.(634-636)cAc>cCc	p.H212P	PCBP3_ENST00000449640.1_Intron|PCBP3_ENST00000468429.1_Intron|PCBP3_ENST00000400308.1_Intron|PCBP3_ENST00000400314.1_Intron|PCBP3_ENST00000400309.1_Intron|PCBP3_ENST00000400310.1_Intron			P57721	PCBP3_HUMAN	poly(rC) binding protein 3	225					mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			biliary_tract(1)|endometrium(3)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		TTACTGCAGCACCCGCCGCTG	0.627000													10	17					0	0	1	0	0
BSDC1	55108	broad.mit.edu	37	1	32841926	32841926	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr1:32841926A>T	ENST00000341071.7	-	9	1155	c.1144T>A	c.(1144-1146)Tta>Ata	p.L382I	BSDC1_ENST00000413080.1_Missense_Mutation_p.L304I|BSDC1_ENST00000419121.2_Missense_Mutation_p.L309I|BSDC1_ENST00000526031.1_Missense_Mutation_p.L270I|BSDC1_ENST00000449308.1_Missense_Mutation_p.L365I|BSDC1_ENST00000455895.2_Missense_Mutation_p.L365I|BSDC1_ENST00000446293.2_Missense_Mutation_p.L382I			Q9NW68	BSDC1_HUMAN	BSD domain containing 1	365							protein binding			breast(1)|central_nervous_system(2)|kidney(1)|lung(6)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	17		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AACACCCGTAAGTCTGTGGGC	0.592000													33	103					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183700742	183700742	+	Silent	SNP	C	C	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr3:183700742C>A	ENST00000334444.6	-	6	885	c.645G>T	c.(643-645)ctG>ctT	p.L215L	ABCC5_ENST00000492216.1_5'UTR|ABCC5_ENST00000265586.6_Silent_p.L215L	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	215	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGCTGTACTGCAGGTTAGACT	0.537000													4	58					0.00909568	0.00939887	1	1	0
GATSL2	729438	broad.mit.edu	37	7	74824244	74824244	+	Silent	SNP	G	G	A			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr7:74824244G>A	ENST00000426327.3	-	2	290	c.123C>T	c.(121-123)ttC>ttT	p.F41F		NM_001145064.1	NP_001138536.1	A6NHX0	GATL2_HUMAN	GATS protein-like 2	41																	TCAGACTGAAGAACTTGCACC	0.552000													7	40					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123753921	123753921	+	Missense_Mutation	SNP	C	C	T	rs114104204	by1000genomes	TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr11:123753921C>T	ENST00000375026.2	-	4	818	c.602G>A	c.(601-603)cGt>cAt	p.R201H		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	201						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						GACAATGCTACGAGGCATTGC	0.418000													20	50					0	0	1	0	0
ARL6IP4	51329	broad.mit.edu	37	12	123466293	123466295	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr12:123466293_123466295delGAA	ENST00000315580.5	+	3	1033_1035	c.705_707delGAA	c.(703-708)agg>ag	p.RK235del	ARL6IP4_ENST00000392435.2_In_Frame_Del_p.RK216del|ARL6IP4_ENST00000454885.2_In_Frame_Del_p.RK101del|ARL6IP4_ENST00000453766.2_In_Frame_Del_p.RK227del|ARL6IP4_ENST00000412505.2_In_Frame_Del_p.RK93del|RP11-197N18.2_ENST00000540866.2_RNA|ARL6IP4_ENST00000543566.1_In_Frame_Del_p.RK216del|ARL6IP4_ENST00000439686.2_In_Frame_Del_p.RK104del|ARL6IP4_ENST00000426960.2_In_Frame_Del_p.RK93del|ARL6IP4_ENST00000357866.4_In_Frame_Del_p.RK104del			Q66PJ3	AR6P4_HUMAN	ADP-ribosylation-like factor 6 interacting protein 4	235	Lys-rich.				RNA splicing	nucleus						all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.11e-05)|Epithelial(86;0.000127)|BRCA - Breast invasive adenocarcinoma(302;0.107)		acaagaggaggaagaagaagaag	0.571													2	4	---	---	---	---					
DHX37	57647	broad.mit.edu	37	12	125465270	125465272	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr12:125465270_125465272delCTC	ENST00000308736.2	-	4	600_602	c.502_504delGAG	c.(502-504)del	p.E168del		NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	168							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.E168delE(3)		breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		CCGATTCCGActcctcctcctcc	0.690													3	4	---	---	---	---					
ZNF468	90333	broad.mit.edu	37	19	53344965	53344965	+	Frame_Shift_Del	DEL	A	A	-			TCGA-86-8668-01A-11D-2393-08	TCGA-86-8668-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b297dac8-3764-4397-b78b-94bb002cf322	323d27d0-2b2a-4dad-a8fe-1d588b0688d3	g.chr19:53344965delA	ENST00000595646.1	-	4	702	c.582delT	c.(580-582)aafs	p.N195fs	ZNF468_ENST00000390651.4_Frame_Shift_Del_p.N142fs|ZNF28_ENST00000594602.1_Intron|ZNF468_ENST00000396409.4_Frame_Shift_Del_p.N142fs|ZNF468_ENST00000243639.4_3'UTR			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	195					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		GGAGGGAATTATTTCCATACT	0.343													57	123	---	---	---	---					
