Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ARHGEF40	55701	broad.mit.edu	37	14	21546383	21546383	+	Silent	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr14:21546383A>T	ENST00000298694.4	+	9	2209	c.2082A>T	c.(2080-2082)gtA>gtT	p.V694V	ARHGEF40_ENST00000298693.3_Silent_p.V694V			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	694					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						TGGGCTCGGTACGGCAGGCCA	0.562000													7	17					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41581999	41581999	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr8:41581999C>A	ENST00000396942.1	-	7	769	c.686G>T	c.(685-687)gGa>gTa	p.G229V	ANK1_ENST00000379758.2_Missense_Mutation_p.G229V|ANK1_ENST00000265709.8_Missense_Mutation_p.G262V|ANK1_ENST00000347528.4_Missense_Mutation_p.G229V|ANK1_ENST00000396945.1_Missense_Mutation_p.G229V|ANK1_ENST00000289734.7_Missense_Mutation_p.G229V|ANK1_ENST00000352337.4_Missense_Mutation_p.G229V			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	229	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GACGCTGGCTCCTCTGTTGAG	0.627000													10	12					4.68919e-08	5.25308e-08	1	1	0
HIST1H1E	3008	broad.mit.edu	37	6	26156697	26156697	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:26156697T>A	ENST00000304218.3	+	1	139	c.79T>A	c.(79-81)Tct>Act	p.S27T		NM_005321.2	NP_005312.1	P10412	H14_HUMAN	histone cluster 1, H1e	27					nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			NS(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|liver(1)|lung(9)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	26						GGCCCGCAAGTCTGCAGGTGC	0.652000													9	91					0	0	1	0	0
KIFC2	90990	broad.mit.edu	37	8	145693759	145693759	+	Silent	SNP	C	C	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr8:145693759C>G	ENST00000301332.2	+	8	1235	c.858C>G	c.(856-858)gcC>gcG	p.A286A	KIFC2_ENST00000301331.5_Silent_p.A34A	NM_145754.2	NP_665697.1	Q96AC6	KIFC2_HUMAN	kinesin family member C2	286	Gln-rich.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(7)|ovary(3)|prostate(3)|skin(2)|urinary_tract(1)	19	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			TTCAGGAGGCCCAAGACACCA	0.672000													10	8					0	0	1	0	0
OR4K17	390436	broad.mit.edu	37	14	20585813	20585813	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr14:20585813C>A	ENST00000315543.4	+	1	248	c.248C>A	c.(247-249)aCc>aAc	p.T83N		NM_001004715.1	NP_001004715.1	Q8NGC6	OR4KH_HUMAN	olfactory receptor, family 4, subfamily K, member 17	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(4)|lung(12)|pancreas(1)|skin(3)	21	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.77e-06)	GBM - Glioblastoma multiforme(265;0.0144)		GTGTTTAACACCCCTAACCTG	0.418000													31	257					1.06801e-11	1.26025e-11	1	1	0
GPR141	353345	broad.mit.edu	37	7	37780086	37780086	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:37780086G>T	ENST00000447769.1	+	4	380	c.91G>T	c.(91-93)Ggg>Tgg	p.G31W	GPR141_ENST00000334425.1_Missense_Mutation_p.G31W|GPR141_ENST00000461610.1_Intron|EPDR1_ENST00000476620.1_Intron			Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	31						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(13)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						GCTTATTGGCGGGCTGGTGGG	0.507000													20	64					5.26018e-13	6.33368e-13	1	1	0
MAGEE2	139599	broad.mit.edu	37	X	75004086	75004086	+	Silent	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chrX:75004086C>A	ENST00000373359.2	-	1	993	c.801G>T	c.(799-801)ctG>ctT	p.L267L		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	267	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						ACACAAACTTCAGGGCTTCCA	0.488000													31	11					1.88708e-17	2.36889e-17	1	1	0
NTRK2	4915	broad.mit.edu	37	9	87338593	87338593	+	Nonsense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr9:87338593G>A	ENST00000304053.6	+	7	1172	c.689G>A	c.(688-690)tGg>tAg	p.W230*	NTRK2_ENST00000359847.3_Nonsense_Mutation_p.W230*|NTRK2_ENST00000376214.1_Nonsense_Mutation_p.W230*|NTRK2_ENST00000323115.4_Nonsense_Mutation_p.W230*|NTRK2_ENST00000376213.1_Nonsense_Mutation_p.W230*|NTRK2_ENST00000277120.3_Nonsense_Mutation_p.W230*|NTRK2_ENST00000376208.1_Nonsense_Mutation_p.W230*|NTRK2_ENST00000395866.2_Nonsense_Mutation_p.W74*|NTRK2_ENST00000395882.1_Nonsense_Mutation_p.W230*	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	230	Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						AATATGTATTGGGATGTTGGT	0.433000										TSP Lung(25;0.17)			21	43					0	0	1	0	0
WNT16	51384	broad.mit.edu	37	7	120979121	120979121	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:120979121C>A	ENST00000222462.2	+	4	1110	c.820C>A	c.(820-822)Cag>Aag	p.Q274K	WNT16_ENST00000361301.2_Missense_Mutation_p.Q264K	NM_057168.1	NP_476509.1	Q9UBV4	WNT16_HUMAN	wingless-type MMTV integration site family, member 16	274					anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|keratinocyte differentiation|keratinocyte proliferation|negative regulation of cell death|optic cup formation involved in camera-type eye development|oxidative stress-induced premature senescence|positive regulation of gene expression|positive regulation of JNK cascade|positive regulation of phosphatidylinositol 3-kinase cascade|replicative senescence|Wnt receptor signaling pathway, calcium modulating pathway	cytoplasm|extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|large_intestine(4)|lung(9)|ovary(3)|prostate(1)	18	all_neural(327;0.117)					AGAAAAAGATCAGAGGAAAAT	0.373000													8	26					0.000157383	0.000166807	1	1	0
RP11-287D1.3	0	broad.mit.edu	37	2	74590199	74590199	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:74590199T>C	ENST00000451608.2	-	2	189	c.190A>G	c.(190-192)Aag>Gag	p.K64E	DCTN1_ENST00000394003.3_Missense_Mutation_p.K1144E|DCTN1_ENST00000409438.1_Missense_Mutation_p.K1012E|DCTN1_ENST00000409868.1_Missense_Mutation_p.K1129E|DCTN1_ENST00000407639.2_Missense_Mutation_p.K1017E|DCTN1_ENST00000409240.1_Missense_Mutation_p.K1109E|DCTN1_ENST00000409567.3_Missense_Mutation_p.K1126E|DCTN1_ENST00000361874.3_Missense_Mutation_p.K1151E																							TGGCTGGTCTTACGATACAGC	0.557000													5	34					0	0	1	0	0
NXF1	10482	broad.mit.edu	37	11	62562464	62562464	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr11:62562464C>A	ENST00000532297.1	-	19	2149	c.1520G>T	c.(1519-1521)cGg>cTg	p.R507L	NXF1_ENST00000294172.2_Missense_Mutation_p.R507L|NXF1_ENST00000531709.2_3'UTR			Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1	507	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(9)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CAAAGAATCCCGGGACTTTCC	0.433000													14	30					1.49906e-05	1.61789e-05	1	1	0
EFHB	151651	broad.mit.edu	37	3	19924092	19924092	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:19924092G>A	ENST00000295824.9	-	12	2439	c.2278C>T	c.(2278-2280)Cgg>Tgg	p.R760W	EFHB_ENST00000344838.4_Missense_Mutation_p.R630W	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	760					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						ACTCCTTTCCGGGCAAAAATG	0.383000													5	7					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157545490	157545490	+	Splice_Site	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:157545490T>A	ENST00000271532.1	-	11	1595	c.1461_splice	c.e11+1	p.K487_splice	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	487						integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GAAACTCACCTTATCCTCTAG	0.448000													41	69					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971762	96971762	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr10:96971762C>T	ENST00000341686.3	+	6	1008	c.883C>T	c.(883-885)Cca>Tca	p.P295S	C10orf129_ENST00000430183.1_Missense_Mutation_p.P140S|C10orf129_ENST00000394005.3_Missense_Mutation_p.P295S	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	295					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		GTGTCACATGCCAACCTTCTG	0.493000													13	31					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167675667	167675667	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:167675667C>A	ENST00000357154.3	-	9	1069	c.932G>T	c.(931-933)aGa>aTa	p.R311I	SPOCK3_ENST00000502330.1_Missense_Mutation_p.R311I|SPOCK3_ENST00000534949.1_Missense_Mutation_p.R215I|SPOCK3_ENST00000510741.1_Missense_Mutation_p.R268I|SPOCK3_ENST00000357545.4_Missense_Mutation_p.R308I|SPOCK3_ENST00000511269.1_Missense_Mutation_p.R308I|SPOCK3_ENST00000421836.2_Missense_Mutation_p.R260I|SPOCK3_ENST00000512681.1_Missense_Mutation_p.R213I|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000512648.1_Missense_Mutation_p.R308I|SPOCK3_ENST00000506886.1_Missense_Mutation_p.R311I|SPOCK3_ENST00000511531.1_Missense_Mutation_p.R311I|SPOCK3_ENST00000504953.1_Missense_Mutation_p.R308I|SPOCK3_ENST00000541637.1_Missense_Mutation_p.R213I|SPOCK3_ENST00000541354.1_Missense_Mutation_p.R191I|SPOCK3_ENST00000535728.1_Missense_Mutation_p.R179I	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	311					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		ACCTTGCTGTCTCTGGAAGCA	0.353000													4	49					0.00024832	0.000261623	1	1	0
MRPS21	54460	broad.mit.edu	37	1	150280578	150280578	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:150280578C>G	ENST00000369084.5	+	2	627	c.180C>G	c.(178-180)tgC>tgG	p.C60W	MRPS21_ENST00000309092.7_Missense_Mutation_p.C60W			P82921	RT21_HUMAN	mitochondrial ribosomal protein S21	60					translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			kidney(1)|large_intestine(1)|lung(1)|pancreas(1)	4	Lung NSC(24;5.57e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			ATGAAAGGTGCCGGCGGATCT	0.542000													11	54					0	0	1	0	0
LHFPL3	375612	broad.mit.edu	37	7	103969338	103969338	+	Silent	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:103969338C>A	ENST00000535008.1	+	1	235	c.111C>A	c.(109-111)ggC>ggA	p.G37G	LHFPL3_ENST00000543266.1_Silent_p.G37G|LHFPL3_ENST00000424859.1_Silent_p.G23G|LHFPL3_ENST00000401970.2_Silent_p.G23G			Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	23						integral to membrane				kidney(1)|large_intestine(2)|lung(6)	9						GGGCCATCGGCGTGCTGTGGG	0.677000													7	40					0.0293803	0.0300597	1	1	0
LGI2	55203	broad.mit.edu	37	4	25005336	25005336	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:25005336G>A	ENST00000382114.4	-	8	1560	c.1375C>T	c.(1375-1377)Ctt>Ttt	p.L459F		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	459						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				CGGGATGGAAGAGCTTGGATC	0.512000													49	103					0	0	1	0	0
GPR125	166647	broad.mit.edu	37	4	22390734	22390734	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:22390734G>A	ENST00000334304.5	-	18	2969	c.2700C>T	c.(2698-2700)taC>taT	p.Y900Y	GPR125_ENST00000282943.5_5'UTR	NM_145290.2	NP_660333.2	Q8IWK6	GP125_HUMAN	G protein-coupled receptor 125	900					neuropeptide signaling pathway	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(33)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	56		Breast(46;0.198)				GCCGACTGCCGTAATTCTTAA	0.418000													42	129					0	0	1	0	0
DDR2	4921	broad.mit.edu	37	1	162740204	162740204	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:162740204C>T	ENST00000367922.2	+	13	1844	c.1406C>T	c.(1405-1407)tCg>tTg	p.S469L	DDR2_ENST00000367921.3_Missense_Mutation_p.S469L	NM_001014796.1	NP_001014796.1	Q16832	DDR2_HUMAN	discoidin domain receptor tyrosine kinase 2	469					cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|kidney(1)|lung(2)|ovary(1)|skin(1)	7	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			GGGTCCAACTCGACTTACGAT	0.507000													26	74					0	0	1	0	0
BLOC1S5-TXNDC5	100526836	broad.mit.edu	37	6	7904823	7904823	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:7904823C>T	ENST00000539054.1	-	2	180	c.181G>A	c.(181-183)Gtg>Atg	p.V61M	BLOC1S5-TXNDC5_ENST00000604490.1_Missense_Mutation_p.V25M|TXNDC5_ENST00000379757.4_Missense_Mutation_p.V133M|TXNDC5_ENST00000473453.1_Missense_Mutation_p.V25M																							TATCCTCGCACCCCCTGGGCG	0.527000													26	42					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	362256	362256	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:362256A>T	ENST00000342640.4	-	8	1126	c.1084T>A	c.(1084-1086)Ttg>Atg	p.L362M	THEG_ENST00000346878.2_Missense_Mutation_p.L338M	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	362					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGGTGGCAAGCTCATAGAG	0.607000													7	105					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103385904	103385904	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:103385904G>T	ENST00000358392.2	-	49	4078	c.3761C>A	c.(3760-3762)cCa>cAa	p.P1254Q	COL11A1_ENST00000370096.3_Missense_Mutation_p.P1242Q|COL11A1_ENST00000353414.4_Missense_Mutation_p.P1203Q|COL11A1_ENST00000512756.1_Missense_Mutation_p.P1126Q	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1242	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AACAGACCCTGGGGGTCCTTG	0.358000													53	51					1.19403e-26	1.65112e-26	1	1	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					5	44					0	0	1	0	0
TNC	3371	broad.mit.edu	37	9	117791723	117791723	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr9:117791723G>A	ENST00000350763.4	-	25	6496	c.6085C>T	c.(6085-6087)Cgc>Tgc	p.R2029C	TNC_ENST00000537320.1_Missense_Mutation_p.R1392C|TNC_ENST00000423613.2_Missense_Mutation_p.R1756C|TNC_ENST00000345230.3_Missense_Mutation_p.R1392C|TNC_ENST00000341037.4_Missense_Mutation_p.R1847C|TNC_ENST00000340094.3_Missense_Mutation_p.R1665C|TNC_ENST00000535648.1_Missense_Mutation_p.R1574C|TNC_ENST00000346706.3_Missense_Mutation_p.R1483C|TNC_ENST00000542877.1_Missense_Mutation_p.R1666C	NM_002160.3	NP_002151.2	P24821	TENA_HUMAN	tenascin C	2029	Fibrinogen C-terminal.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			NS(3)|breast(5)|central_nervous_system(4)|endometrium(8)|kidney(6)|large_intestine(32)|liver(1)|lung(39)|ovary(1)|pancreas(2)|prostate(5)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	120						CCGTTTTTGCGTCTCAGGAAC	0.488000													21	64					0	0	1	0	0
HADHB	3032	broad.mit.edu	37	2	26486306	26486306	+	Silent	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:26486306G>T	ENST00000317799.5	+	4	272	c.168G>T	c.(166-168)gtG>gtT	p.V56V	HADHB_ENST00000545822.1_Silent_p.V34V|HADHB_ENST00000537713.1_Silent_p.V56V|HADHB_ENST00000405867.3_Silent_p.V56V|HADHB_ENST00000494615.1_3'UTR	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	56					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATGTTGTGGTGGTGGATGGTG	0.338000													27	73					7.01153e-11	8.05871e-11	1	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85449856	85449856	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr12:85449856G>T	ENST00000393217.2	+	8	1346	c.1285G>T	c.(1285-1287)Gaa>Taa	p.E429*		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	429										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TCTAGTGGATGAAAATTCAAA	0.299000													32	75					3.11337e-16	3.85362e-16	1	1	0
MCTP2	55784	broad.mit.edu	37	15	94943177	94943177	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr15:94943177C>G	ENST00000357742.4	+	15	1918	c.1918C>G	c.(1918-1920)Ccc>Gcc	p.P640A	MCTP2_ENST00000451018.3_Missense_Mutation_p.P640A|MCTP2_ENST00000331706.4_Missense_Mutation_p.P228A|MCTP2_ENST00000557742.1_Missense_Mutation_p.P228A	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	640					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			GACTTTTACTCCCCGGGAAAA	0.463000													6	100					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62298882	62298882	+	Silent	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr20:62298882G>T	ENST00000318100.4	+	8	1502	c.675G>T	c.(673-675)ccG>ccT	p.P225P	RTEL1-TNFRSF6B_ENST00000482936.1_Silent_p.P225P|RTEL1_ENST00000360203.5_Silent_p.P225P|RTEL1_ENST00000370018.3_Silent_p.P225P|RTEL1_ENST00000508582.2_Silent_p.P249P			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	225	Helicase ATP-binding.				DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding	p.P225P(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			TATTCATGCCGTACAATTACT	0.572000													26	378					2.49675e-24	3.37347e-24	1	1	0
B3GAT2	135152	broad.mit.edu	37	6	71665907	71665907	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:71665907C>T	ENST00000230053.6	-	1	834	c.226G>A	c.(226-228)Gag>Aag	p.E76K		NM_080742.2	NP_542780.1	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2 (glucuronosyltransferase S)	76					carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|urinary_tract(1)	16						AGCTGCGGCTCCGGCTGTGGC	0.731000													5	24					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123252502	123252502	+	Silent	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:123252502A>G	ENST00000264501.4	+	67	11644	c.11271A>G	c.(11269-11271)gcA>gcG	p.A3757A	KIAA1109_ENST00000388738.3_Silent_p.A3757A			Q2LD37	K1109_HUMAN	KIAA1109	3757					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						GTAAAAAAGCAACAGGCTTTG	0.363000													8	7					0	0	1	0	0
LGALS2	3957	broad.mit.edu	37	22	37966361	37966361	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr22:37966361A>T	ENST00000215886.4	-	4	482	c.308T>A	c.(307-309)cTg>cAg	p.L103Q		NM_006498.2	NP_006489.1	P05162	LEG2_HUMAN	lectin, galactoside-binding, soluble, 2	103	Galectin.									breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|stomach(1)	11	Melanoma(58;0.0574)					GGGAAAAGTCAGCTCGTGCCC	0.527000													6	38					0	0	1	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117420573	117420573	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:117420573G>A	ENST00000160373.3	-	7	2536	c.2445C>T	c.(2443-2445)taC>taT	p.Y815Y		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	815										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TACAGGCCAGGTATAGAGGTG	0.343000													13	60					0	0	1	0	0
PLEKHA8P1	51054	broad.mit.edu	37	12	45567064	45567064	+	RNA	SNP	C	C	G	rs146414684	byFrequency	TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr12:45567064C>G	ENST00000256692.5	-	0	1621					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGCTTCTTTCCGGTGGTCACC	0.498000													36	76					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143853423	143853423	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:143853423C>T	ENST00000507359.2	+	3	2124	c.1033C>T	c.(1033-1035)Ccc>Tcc	p.P345S	KCTD16_ENST00000512467.1_Missense_Mutation_p.P345S	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16	345						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TCTGGACCGTCCCATCAAGAA	0.582000													7	72					0	0	1	0	0
PRKCB	5579	broad.mit.edu	37	16	23848702	23848702	+	Silent	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr16:23848702C>T	ENST00000303531.7	+	2	332	c.180C>T	c.(178-180)ttC>ttT	p.F60F	PRKCB_ENST00000321728.7_Silent_p.F60F|PRKCB_ENST00000498058.1_Intron	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	60					apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	GCAGGGGCTTCGGGAAGCAGG	0.557000													27	174					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189872832	189872832	+	Silent	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:189872832A>T	ENST00000304636.3	+	47	3659	c.3489A>T	c.(3487-3489)ccA>ccT	p.P1163P	COL3A1_ENST00000317840.5_Silent_p.P860P	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1163	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	TTGGACCACCAGGGCCTCGAG	0.458000													9	17					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35064606	35064606	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr20:35064606G>T	ENST00000373913.3	+	4	1574	c.1094G>T	c.(1093-1095)cGc>cTc	p.R365L	DLGAP4_ENST00000339266.5_Missense_Mutation_p.R365L|DLGAP4_ENST00000401952.2_Missense_Mutation_p.R365L|DLGAP4_ENST00000373907.2_Missense_Mutation_p.R365L			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	365					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CGGCGCATGCGCAGCGGCAGC	0.741000													3	14					0.115264	0.115919	1	1	0
SH3BP4	23677	broad.mit.edu	37	2	235951476	235951476	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:235951476A>T	ENST00000409212.1	+	4	2570	c.2063A>T	c.(2062-2064)gAg>gTg	p.E688V	SH3BP4_ENST00000344528.4_Missense_Mutation_p.E688V|SH3BP4_ENST00000392011.2_Missense_Mutation_p.E688V			Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	688					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(6)|stomach(3)|urinary_tract(2)	44		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CTGCTCAGCGAGGAGCGGGTC	0.607000													23	37					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54783699	54783699	+	Silent	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chrX:54783699G>T	ENST00000218436.6	-	8	2837	c.2808C>A	c.(2806-2808)ccC>ccA	p.P936P		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	936	Pro-rich.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										ACCTTCCAGGGGGCAGAGTGG	0.562000													15	6					4.7546e-09	5.42945e-09	1	1	0
TRPA1	8989	broad.mit.edu	37	8	72975067	72975067	+	Nonsense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr8:72975067G>T	ENST00000262209.4	-	6	981	c.774C>A	c.(772-774)tgC>tgA	p.C258*		NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	258						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	CATTGTCCAGGCACATTTTGA	0.378000													23	88					3.28513e-13	3.98265e-13	1	1	0
IFT88	8100	broad.mit.edu	37	13	21190012	21190012	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr13:21190012A>G	ENST00000382778.4	+	15	2338	c.1220A>G	c.(1219-1221)tAt>tGt	p.Y407C	IFT88_ENST00000537103.1_Missense_Mutation_p.Y379C|IFT88_ENST00000461115.1_3'UTR|IFT88_ENST00000351808.5_Missense_Mutation_p.Y398C|IFT88_ENST00000319980.6_Missense_Mutation_p.Y407C			Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog (Chlamydomonas)	407				Y -> C (in Ref. 1; AAA86720).	cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	27		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		GCTGCAGGTTATGATTGGTAA	0.279000													10	27					0	0	1	0	0
ADRBK2	157	broad.mit.edu	37	22	26091116	26091116	+	Silent	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr22:26091116G>T	ENST00000324198.5	+	13	1287	c.1095G>T	c.(1093-1095)ggG>ggT	p.G365G		NM_005160.3	NP_005151.2	P35626	ARBK2_HUMAN	adrenergic, beta, receptor kinase 2	365	Protein kinase.						ATP binding|beta-adrenergic receptor kinase activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|ovary(2)|skin(3)|stomach(2)	32					Adenosine triphosphate(DB00171)	TGCAGAAGGGGACGGCCTATG	0.512000													29	50					3.73148e-12	4.43269e-12	1	1	0
NF1	4763	broad.mit.edu	37	17	29677299	29677299	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr17:29677299G>A	ENST00000358273.4	+	50	7803	c.7420G>A	c.(7420-7422)Gat>Aat	p.D2474N	NF1_ENST00000417592.2_Missense_Mutation_p.D187N|NF1_ENST00000356175.3_Missense_Mutation_p.D2453N|NF1_ENST00000444181.2_Missense_Mutation_p.D267N	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	2474					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TGTTCCTATGGATACATATCC	0.348000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			8	70					0	0	1	0	0
DNAH2	146754	broad.mit.edu	37	17	7721687	7721687	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr17:7721687G>A	ENST00000572933.1	+	69	11905	c.10445G>A	c.(10444-10446)cGt>cAt	p.R3482H	DNAH2_ENST00000389173.2_Missense_Mutation_p.R3482H			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	3482	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				ACCAATTTCCGTTTCTACATC	0.522000													77	93					0	0	1	0	0
CSTF3	1479	broad.mit.edu	37	11	33127179	33127179	+	Silent	SNP	T	T	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr11:33127179T>C	ENST00000323959.4	-	8	658	c.519A>G	c.(517-519)caA>caG	p.Q173Q	TCP11L1_ENST00000324357.9_3'UTR	NM_001326.2	NP_001317.1	Q12996	CSTF3_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa	173					mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	protein binding|RNA binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|stomach(1)	19						CACAACCTCGTTGATAAACTC	0.353000													23	33					0	0	1	0	0
MORN1	79906	broad.mit.edu	37	1	2268207	2268207	+	Silent	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:2268207C>T	ENST00000378531.3	-	11	1292	c.1119G>A	c.(1117-1119)ggG>ggA	p.G373G	MORN1_ENST00000606372.1_5'UTR	NM_024848.1	NP_079124.1	Q5T089	MORN1_HUMAN	MORN repeat containing 1	373										breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|liver(1)|lung(1)|ovary(2)	9	all_cancers(77;0.000194)|all_epithelial(69;9.96e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.3e-15)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;2.21e-37)|OV - Ovarian serous cystadenocarcinoma(86;5.01e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00137)|BRCA - Breast invasive adenocarcinoma(365;0.00488)|STAD - Stomach adenocarcinoma(132;0.00665)|KIRC - Kidney renal clear cell carcinoma(229;0.0203)|Lung(427;0.212)		GCGGGGGCGGCCCCAGGAGGA	0.662000													5	10					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6828653	6828653	+	Silent	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:6828653C>T	ENST00000304076.2	+	12	1207	c.1113C>T	c.(1111-1113)aaC>aaT	p.N371N	VAV1_ENST00000539284.1_Silent_p.N274N|VAV1_ENST00000602142.1_Silent_p.N371N|VAV1_ENST00000599806.1_Silent_p.N316N|VAV1_ENST00000596764.1_Silent_p.N339N	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	371	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						AGTGCGTGAACGAGGTCAAGC	0.637000													12	176					0	0	1	0	0
TRBV27	28560	broad.mit.edu	37	7	142423650	142423650	+	RNA	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:142423650C>A	ENST00000506718.1	+	0	658				TRBV27_ENST00000390399.3_RNA																							CGCCCAGCCCCAACCAGACCT	0.507000													4	34					0.014758	0.0153657	1	1	0
SEMA4C	54910	broad.mit.edu	37	2	97527481	97527481	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:97527481G>A	ENST00000305476.5	-	13	1726	c.1594C>T	c.(1594-1596)Cac>Tac	p.H532Y		NM_017789.4	NP_060259.4	Q9C0C4	SEM4C_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	532	PSI.				muscle cell differentiation|nervous system development|positive regulation of stress-activated MAPK cascade	cell junction|integral to membrane|postsynaptic density|postsynaptic membrane|synaptic vesicle membrane	receptor activity			NS(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	17						CACCCAGAGTGGCCACCCACG	0.617000													18	97					0	0	1	0	0
CD5L	922	broad.mit.edu	37	1	157804213	157804213	+	Silent	SNP	C	C	T	rs74121553	byFrequency	TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:157804213C>T	ENST00000368174.4	-	4	798	c.702G>A	c.(700-702)acG>acA	p.T234T		NM_005894.2	NP_005885.1	O43866	CD5L_HUMAN	CD5 molecule-like	234	SRCR 2.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	52	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			ATTCGACCCACGTGTCTTCAT	0.463000													10	27					0	0	1	0	0
TMEM132C	92293	broad.mit.edu	37	12	128899854	128899854	+	Silent	SNP	G	G	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr12:128899854G>C	ENST00000435159.2	+	2	663	c.663G>C	c.(661-663)ccG>ccC	p.P221P		NM_001136103.2	NP_001129575.2	Q8N3T6	T132C_HUMAN	transmembrane protein 132C	221						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|lung(2)|prostate(2)|skin(1)	13						TGGACCAGCCGGAGGGGACCC	0.662000													3	7					0	0	1	0	0
PGK2	5232	broad.mit.edu	37	6	49754723	49754723	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:49754723G>T	ENST00000304801.3	-	1	330	c.178C>A	c.(178-180)Ctt>Att	p.L60I		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	60					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					TGACTCATAAGAACTACTGCC	0.478000													41	75					1.04594e-18	1.33188e-18	1	1	0
PSMA8	143471	broad.mit.edu	37	18	23724603	23724603	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr18:23724603G>A	ENST00000308268.6	+	2	272	c.183G>A	c.(181-183)gtG>gtA	p.V61V	PSMA8_ENST00000343848.6_Intron|PSMA8_ENST00000415576.2_Silent_p.V61V	NM_001025096.1|NM_144662.2	NP_001020267.1|NP_653263.2	Q8TAA3	PSA7L_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 8	61					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|skin(2)	16	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			AAAGAACTGTGAGGAAAATTT	0.398000													10	60					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62502316	62502316	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:62502316T>A	ENST00000383710.4	-	15	2745	c.2396A>T	c.(2395-2397)tAt>tTt	p.Y799F	CADPS_ENST00000357948.3_Missense_Mutation_p.Y782F|CADPS_ENST00000283269.9_Missense_Mutation_p.Y799F	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	799	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TGGAAAGCAATACCTAAAAAA	0.343000													12	25					0	0	1	0	0
TNFSF10	8743	broad.mit.edu	37	3	172241058	172241058	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:172241058G>A	ENST00000241261.2	-	1	239	c.117C>T	c.(115-117)acC>acT	p.T39T	TNFSF10_ENST00000420541.2_Silent_p.T39T	NM_003810.3	NP_003801.1	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily, member 10	39					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			breast(2)|cervix(1)|large_intestine(1)|lung(6)|ovary(1)|skin(4)	15	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TCAGCTCGTTGGTAAAGTACA	0.547000													7	96					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503745	140503745	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:140503745G>A	ENST00000194152.1	+	1	2165	c.2165G>A	c.(2164-2166)gGt>gAt	p.G722D		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		722					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCTCGGTGGGTCGCTGCTCG	0.672000													60	192					0	0	1	0	0
GDF9	2661	broad.mit.edu	37	5	132200160	132200160	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:132200160G>A	ENST00000378673.2	-	2	932	c.66C>T	c.(64-66)agC>agT	p.S22S	GDF9_ENST00000296875.2_Silent_p.S22S|GDF9_ENST00000464378.1_Intron			O60383	GDF9_HUMAN	growth differentiation factor 9	22					female gamete generation|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			NS(1)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	22		all_cancers(142;0.105)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAGAACCAAGGCTAATAGGAA	0.493000											OREG0003471	type=REGULATORY REGION|Gene=GDF9|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	78					0	0	1	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296369	39296369	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr17:39296369C>A	ENST00000345847.4	-	1	370	c.371G>T	c.(370-372)tGc>tTc	p.C124F		NM_030976.1	NP_112238.1	Q9BYQ5	KRA46_HUMAN	keratin associated protein 4-6	120	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						GGACCTGCAGCACCTGGACAC	0.652000													12	41					5.50884e-06	5.98199e-06	1	1	0
TPST1	8460	broad.mit.edu	37	7	65705780	65705780	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:65705780G>A	ENST00000304842.5	+	2	793	c.368G>A	c.(367-369)cGc>cAc	p.R123H	TPST1_ENST00000480281.1_Intron	NM_003596.3	NP_003587.1	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	123					inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						GAGAAGATCCGCCTGGATGAG	0.507000													5	56					0	0	1	0	0
TPRKB	51002	broad.mit.edu	37	2	73961682	73961682	+	Missense_Mutation	SNP	A	A	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:73961682A>C	ENST00000318190.7	-	2	135	c.15T>G	c.(13-15)caT>caG	p.H5Q	TPRKB_ENST00000409716.2_Missense_Mutation_p.H5Q|TPRKB_ENST00000272424.5_Missense_Mutation_p.H5Q			Q9Y3C4	TPRKB_HUMAN	TP53RK binding protein	5					protein catabolic process	cytosol|nucleus	protein kinase binding			lung(2)|ovary(1)|skin(1)	4						GGTCCAGCTGATGTGTTAACT	0.383000													7	57					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140250404	140250404	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:140250404G>A	ENST00000398640.2	+	1	1716	c.1716G>A	c.(1714-1716)gcG>gcA	p.A572A	PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGCAGCGCGGGAGGCGCAG	0.682000													19	164					0	0	1	0	0
MEOX1	4222	broad.mit.edu	37	17	41738630	41738630	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr17:41738630G>A	ENST00000549132.1	-	1	301	c.185C>T	c.(184-186)cCc>cTc	p.P62L	MEOX1_ENST00000329168.3_Silent_p.S91S|MEOX1_ENST00000393661.2_5'UTR|MEOX1_ENST00000318579.4_Silent_p.S91S			P50221	MEOX1_HUMAN	mesenchyme homeobox 1	39						nucleus	sequence-specific DNA binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)	8		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.0753)		GCCAGTTGGGGGACTGTGGGA	0.667000													10	110					0	0	1	0	0
VEGFC	7424	broad.mit.edu	37	4	177632711	177632711	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:177632711C>A	ENST00000280193.2	-	4	1061	c.646G>T	c.(646-648)Gat>Tat	p.D216Y	VEGFC_ENST00000507638.1_5'UTR	NM_005429.2	NP_005420.1	P49767	VEGFC_HUMAN	vascular endothelial growth factor C	216					angiogenesis|induction of positive chemotaxis|platelet activation|platelet degranulation|positive regulation of cell division|positive regulation of mast cell chemotaxis|substrate-dependent cell migration|vascular endothelial growth factor receptor signaling pathway	membrane|platelet alpha granule lumen	chemoattractant activity|growth factor activity			biliary_tract(1)|cervix(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(2)|skin(2)	41		Breast(14;0.000223)|Renal(120;0.00988)|Prostate(90;0.00996)|Melanoma(52;0.0101)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;1.59e-18)|Epithelial(43;3.68e-16)|OV - Ovarian serous cystadenocarcinoma(60;8.52e-09)|GBM - Glioblastoma multiforme(59;0.000546)|STAD - Stomach adenocarcinoma(60;0.00308)|Colorectal(24;0.025)|COAD - Colon adenocarcinoma(29;0.0359)|LUSC - Lung squamous cell carcinoma(193;0.0397)		CTGTAAACATCCAGTTTAGAC	0.393000													30	19					1.08312e-15	1.33134e-15	1	1	0
ARHGAP5	394	broad.mit.edu	37	14	32563191	32563191	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr14:32563191G>C	ENST00000345122.3	+	2	3631	c.3316G>C	c.(3316-3318)Gat>Cat	p.D1106H	ARHGAP5_ENST00000396582.2_Intron|ARHGAP5_ENST00000556611.1_Missense_Mutation_p.D1106H|ARHGAP5_ENST00000539826.2_Missense_Mutation_p.D1106H|ARHGAP5_ENST00000433497.1_Intron|ARHGAP5_ENST00000432921.1_Missense_Mutation_p.D1106H	NM_001030055.1	NP_001025226.1	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5	1106					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(10)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(12)|ovary(4)|skin(1)|stomach(1)|urinary_tract(4)	55	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		GGGCTATTCTGATGAGATTTA	0.388000													23	107					0	0	1	0	0
ZNF430	80264	broad.mit.edu	37	19	21240746	21240746	+	Silent	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:21240746A>G	ENST00000261560.5	+	5	1813	c.1632A>G	c.(1630-1632)gaA>gaG	p.E544E		NM_001172671.1|NM_025189.3	NP_001166142.1|NP_079465.3	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	544					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	23						ACAACTGTGAAGAATACGGCA	0.378000													7	34					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50682474	50682474	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:50682474C>T	ENST00000403097.1	-	11	1850	c.1070G>A	c.(1069-1071)tGc>tAc	p.C357Y	GRB10_ENST00000402578.1_Missense_Mutation_p.C305Y|GRB10_ENST00000357271.5_Missense_Mutation_p.C317Y|GRB10_ENST00000439599.1_Missense_Mutation_p.C357Y|GRB10_ENST00000402497.1_Missense_Mutation_p.C305Y|GRB10_ENST00000406641.1_Missense_Mutation_p.C305Y|GRB10_ENST00000335866.3_Missense_Mutation_p.C305Y|GRB10_ENST00000401949.1_Missense_Mutation_p.C363Y|GRB10_ENST00000398810.2_Missense_Mutation_p.C305Y|GRB10_ENST00000407526.1_Missense_Mutation_p.C305Y|GRB10_ENST00000398812.2_Missense_Mutation_p.C363Y			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	363	PH.				insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					TACCTTTATGCAGAGCCCGTG	0.582000									Russell-Silver syndrome				10	90					0	0	1	0	0
CDKN2AIP	55602	broad.mit.edu	37	4	184366803	184366803	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:184366803A>G	ENST00000504169.1	+	2	595	c.388A>G	c.(388-390)Ata>Gta	p.I130V	CDKN2AIP_ENST00000506835.1_Intron|CDKN2AIP_ENST00000302350.4_Intron|CDKN2AIP_ENST00000510928.1_Missense_Mutation_p.I130V	NM_017632.2	NP_060102.1	Q9NXV6	CARF_HUMAN	CDKN2A interacting protein	130					negative regulation of cell growth|positive regulation of signal transduction|regulation of protein stability	granular component|nucleoplasm	double-stranded RNA binding|p53 binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(1)	6		all_lung(41;6.9e-12)|Lung NSC(41;1.28e-11)|Colorectal(36;0.00435)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;1.15e-26)|Epithelial(43;2.98e-22)|OV - Ovarian serous cystadenocarcinoma(60;7.64e-10)|GBM - Glioblastoma multiforme(59;4.22e-06)|Colorectal(24;5.87e-06)|STAD - Stomach adenocarcinoma(60;2.09e-05)|COAD - Colon adenocarcinoma(29;5.15e-05)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.155)		GAAAAGAGGGATATCGAGTAG	0.343000													10	29					0	0	1	0	0
ABCC12	94160	broad.mit.edu	37	16	48174751	48174751	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr16:48174751G>A	ENST00000311303.3	-	4	849	c.504C>T	c.(502-504)gcC>gcT	p.A168A	ABCC12_ENST00000448542.1_Silent_p.A168A|ABCC12_ENST00000416054.1_Silent_p.A168A	NM_033226.2	NP_150229.2	Q96J65	MRP9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 12	168	ABC transmembrane type-1 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|liver(1)|lung(43)|ovary(2)|prostate(3)|skin(7)|urinary_tract(1)	90		all_cancers(37;0.0474)|all_lung(18;0.047)				TGGCAAAAAGGGCTATGCACA	0.542000													7	103					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117376377	117376377	+	Silent	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr11:117376377C>A	ENST00000321322.6	-	9	2035	c.2034G>T	c.(2032-2034)gtG>gtT	p.V678V	DSCAML1_ENST00000527706.1_Silent_p.V408V	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	618	Ig-like C2-type 7.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CCGAGGACACCACACAGGGAA	0.612000													18	10					2.94398e-08	3.34029e-08	1	1	0
SPINT1	6692	broad.mit.edu	37	15	41146707	41146707	+	Silent	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr15:41146707T>A	ENST00000344051.4	+	7	1335	c.1101T>A	c.(1099-1101)gcT>gcA	p.A367A	SPINT1_ENST00000562057.1_Silent_p.A351A|SPINT1_ENST00000431806.1_Silent_p.A351A			O43278	SPIT1_HUMAN	serine peptidase inhibitor, Kunitz type 1	367	LDL-receptor class A.					extracellular region|membrane fraction	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	16		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		CCGACGAGGCTGCCTGTGAAA	0.632000													9	41					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9089747	9089747	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:9089747A>T	ENST00000397910.4	-	1	2271	c.2068T>A	c.(2068-2070)Ttc>Atc	p.F690I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	690	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCTTCCCTGAAAGCTGAGGAC	0.507000													30	26					0	0	1	0	0
SRP54	6729	broad.mit.edu	37	14	35497312	35497312	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr14:35497312A>T	ENST00000556994.1	+	16	1743	c.1346A>T	c.(1345-1347)aAt>aTt	p.N449I	SRP54_ENST00000546080.1_Missense_Mutation_p.N400I|SRP54_ENST00000216774.6_Missense_Mutation_p.N449I|SRP54_ENST00000555557.1_Missense_Mutation_p.N385I			P61011	SRP54_HUMAN	signal recognition particle 54kDa	449	M-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		ATGTCTAAGAATGTGAGCCAG	0.388000													9	117					0	0	1	0	0
DZANK1	55184	broad.mit.edu	37	20	18370471	18370471	+	Splice_Site	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr20:18370471C>A	ENST00000357236.4	-	20	2209	c.1548_splice	c.e20-1	p.G517_splice	DZANK1_ENST00000487128.1_5'UTR|DZANK1_ENST00000262547.5_Splice_Site_p.G631_splice|DZANK1_ENST00000377630.5_Splice_Site_p.G464_splice|DZANK1_ENST00000329494.5_Splice_Site_p.G609_splice			Q9NVP4	CT012_HUMAN	double zinc ribbon and ankyrin repeat domains 1	458						intracellular	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(5)|lung(10)	19						GGGGTCTGCTCCCTGCAGCAA	0.488000													46	100					8.28887e-21	1.08676e-20	1	1	0
COL6A3	1293	broad.mit.edu	37	2	238277227	238277227	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:238277227T>C	ENST00000295550.4	-	10	5331	c.4879A>G	c.(4879-4881)Acc>Gcc	p.T1627A	COL6A3_ENST00000353578.4_Missense_Mutation_p.T1421A|COL6A3_ENST00000347401.3_Missense_Mutation_p.T1426A|COL6A3_ENST00000346358.4_Missense_Mutation_p.T1427A|COL6A3_ENST00000409809.1_Missense_Mutation_p.T1421A|COL6A3_ENST00000472056.1_Missense_Mutation_p.T1020A	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1627	Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAGGAGGGGTGTCCACCCCT	0.478000													12	49					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000404276.1_Silent_p.S372S	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					5	43					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211512729	211512729	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:211512729T>C	ENST00000233072.5	+	26	3480	c.3284T>C	c.(3283-3285)gTc>gCc	p.V1095A	CPS1_ENST00000451903.2_Missense_Mutation_p.V644A|CPS1_ENST00000430249.2_Missense_Mutation_p.V1101A	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1095	ATP-grasp 2.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TTCTCAGCTGTCTTGGATGAG	0.468000													7	62					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68138983	68138983	+	Silent	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr10:68138983A>T	ENST00000433211.1	-	12	1833	c.1659T>A	c.(1657-1659)ggT>ggA	p.G553G	CTNNA3_ENST00000373744.4_Silent_p.G553G	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	553					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TGTCCATTTCACCCGTGACGA	0.483000													25	69					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43259343	43259343	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:43259343C>A	ENST00000404209.4	-	4	881	c.785G>T	c.(784-786)tGt>tTt	p.C262F	PSG8_ENST00000406636.3_Missense_Mutation_p.C140F|PSG8_ENST00000306511.4_Missense_Mutation_p.C262F|PSG8_ENST00000401467.2_Missense_Mutation_p.C169F|PSG8_ENST00000600709.1_Intron	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	262	Ig-like C2-type 2.					extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				CTTAGGTTCACAGGTGAAGTT	0.473000													37	147					2.2871e-25	3.11397e-25	1	1	0
IMPDH2	3615	broad.mit.edu	37	3	49062560	49062560	+	Splice_Site	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:49062560T>A	ENST00000326739.4	-	10	1188	c.1150_splice	c.e10+1	p.T383_splice		NM_000884.2	NP_000875.2	P12268	IMDH2_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 2	383					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	GGGCCTCACCTGTGGAGGCCC	0.572000													13	53					0	0	1	0	0
IRF4	3662	broad.mit.edu	37	6	401621	401621	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:401621G>A	ENST00000380956.4	+	7	1069	c.943G>A	c.(943-945)Gtg>Atg	p.V315M		NM_001195286.1|NM_002460.3	NP_001182215.1|NP_002451.2	Q15306	IRF4_HUMAN	interferon regulatory factor 4	315					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|ovary(2)	5		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		GGAGAGGGGCGTGGTCCTCTG	0.617000			T	IGH@	MM								20	23					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229771	140229771	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:140229771C>T	ENST00000378122.3	+	1	2415	c.1691C>T	c.(1690-1692)gCg>gTg	p.A564V	PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.A564V|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGCGCCGGCGCTGCTGACA	0.692000													9	101					0	0	1	0	0
TRIB3	57761	broad.mit.edu	37	20	377234	377234	+	Missense_Mutation	SNP	G	G	A	rs146704824		TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr20:377234G>A	ENST00000217233.3	+	4	1530	c.977G>A	c.(976-978)cGa>cAa	p.R326Q	TRIB3_ENST00000422053.2_Missense_Mutation_p.R353Q	NM_021158.3	NP_066981.2	Q96RU7	TRIB3_HUMAN	tribbles pseudokinase 3	326					apoptosis|cellular lipid metabolic process|insulin receptor signaling pathway|negative regulation of fat cell differentiation|negative regulation of fatty acid biosynthetic process|negative regulation of protein kinase activity|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein binding|positive regulation of ubiquitin-protein ligase activity|regulation of glucose transport|regulation of MAP kinase activity|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	ATP binding|protein kinase activity|protein kinase binding|protein kinase inhibitor activity|transcription corepressor activity|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|skin(1)	21		all_epithelial(17;0.165)|Lung NSC(37;0.191)|Breast(17;0.231)		Colorectal(46;0.101)|COAD - Colon adenocarcinoma(99;0.112)		GCCCCAACCCGATCCCATCTC	0.642000													12	88					0	0	1	0	0
PCDH18	54510	broad.mit.edu	37	4	138449668	138449668	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:138449668T>A	ENST00000344876.4	-	3	3090	c.2704A>T	c.(2704-2706)Agc>Tgc	p.S902C	PCDH18_ENST00000412923.2_Missense_Mutation_p.S901C|PCDH18_ENST00000511115.1_Missense_Mutation_p.S82C|PCDH18_ENST00000510305.1_Missense_Mutation_p.S113C|PCDH18_ENST00000507846.1_Missense_Mutation_p.S681C	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	902	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					AACAGGTCGCTGAATCCTTCA	0.443000													15	110					0	0	1	0	0
TXLNG	55787	broad.mit.edu	37	X	16855748	16855748	+	Missense_Mutation	SNP	C	C	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chrX:16855748C>G	ENST00000380122.5	+	8	1153	c.1092C>G	c.(1090-1092)ttC>ttG	p.F364L	TXLNG_ENST00000398155.4_Missense_Mutation_p.F232L	NM_018360.2	NP_060830.2	Q9NUQ3	TXLNG_HUMAN	taxilin gamma	364					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane				breast(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	15						TTGAAGAATTCCAGACTACCA	0.313000													5	16					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1893093	1893093	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:1893093C>A	ENST00000399161.2	-	16	3187	c.2440G>T	c.(2440-2442)Ggc>Tgc	p.G814C	MYT1L_ENST00000428368.2_Missense_Mutation_p.G812C	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	814					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		CAGCAGTCGCCCTCGCCCAGC	0.587000													21	41					1.2644e-06	1.38148e-06	1	1	0
RALYL	138046	broad.mit.edu	37	8	85441638	85441638	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr8:85441638C>A	ENST00000521268.1	+	2	1187	c.82C>A	c.(82-84)Cta>Ata	p.L28I	RALYL_ENST00000518566.1_Missense_Mutation_p.L28I|RALYL_ENST00000517638.1_Missense_Mutation_p.L41I|RALYL_ENST00000522455.1_Missense_Mutation_p.L28I|RALYL_ENST00000521695.1_Missense_Mutation_p.L28I	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	28	RRM.						identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						CATCGGCAATCTAAATACGGC	0.403000													7	16					8.12818e-05	8.71932e-05	1	1	0
SAMD9	54809	broad.mit.edu	37	7	92733183	92733183	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:92733183C>A	ENST00000379958.2	-	3	2497	c.2228G>T	c.(2227-2229)gGa>gTa	p.G743V		NM_001193307.1|NM_017654.3	NP_001180236.1|NP_060124.2	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	743						cytoplasm				NS(1)|breast(4)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(20)|lung(32)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	88	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CAAGGTAGTTCCCCCACAGCC	0.383000													83	109					1.52223e-32	2.12153e-32	1	1	0
PCDHB3	56132	broad.mit.edu	37	5	140480899	140480899	+	Silent	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:140480899G>T	ENST00000231130.2	+	1	666	c.666G>T	c.(664-666)cgG>cgT	p.R222R	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		222	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTCCCCCTCGGTCTGGGACAG	0.547000													41	21					6.2361e-21	8.23724e-21	1	1	0
SI	6476	broad.mit.edu	37	3	164786517	164786517	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:164786517C>A	ENST00000264382.3	-	5	538	c.476G>T	c.(475-477)cGg>cTg	p.R159L		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	159	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	AACCTTGAACCGGAAACGATT	0.423000										HNSCC(35;0.089)			44	63					1.76056e-25	2.41565e-25	1	1	0
IFIT1B	439996	broad.mit.edu	37	10	91144365	91144365	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr10:91144365A>G	ENST00000371809.3	+	2	1375	c.1295A>G	c.(1294-1296)cAg>cGg	p.Q432R	LIPA_ENST00000371837.1_Intron	NM_001010987.2	NP_001010987.1	Q5T764	IFT1B_HUMAN	interferon-induced protein with tetratricopeptide repeats 1B	432							binding			endometrium(2)|large_intestine(3)|lung(8)	13						TGTATTCACCAGAATGTACGG	0.393000													38	88					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39100310	39100310	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:39100310G>T	ENST00000591517.1	-	13	960	c.932C>A	c.(931-933)cCc>cAc	p.P311H	MAP4K1_ENST00000589130.1_Missense_Mutation_p.P307H|MAP4K1_ENST00000589002.1_5'UTR|MAP4K1_ENST00000586296.1_Missense_Mutation_p.P311H|MAP4K1_ENST00000396857.2_Missense_Mutation_p.P311H|MAP4K1_ENST00000423454.2_5'UTR	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	311					activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			GATAGCAGGGGGTAGCTGGGC	0.622000													5	13					0.184627	0.184627	1	1	0
GTPBP4	23560	broad.mit.edu	37	10	1034431	1034431	+	Nonsense_Mutation	SNP	C	C	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr10:1034431C>G	ENST00000360803.4	+	1	94	c.12C>G	c.(10-12)taC>taG	p.Y4*	GTPBP4_ENST00000491635.1_3'UTR|GTPBP4_ENST00000538293.1_5'UTR	NM_012341.2	NP_036473.2	Q9BZE4	NOG1_HUMAN	GTP binding protein 4	4					negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of collagen binding|negative regulation of DNA replication|negative regulation of protein ubiquitination|protein stabilization|regulation of cyclin-dependent protein kinase activity|ribosome biogenesis	nucleolus|perinuclear region of cytoplasm	GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|prostate(2)|skin(1)	21		all_epithelial(10;0.107)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.0814)	Epithelial(11;0.0513)|all cancers(11;0.135)|OV - Ovarian serous cystadenocarcinoma(14;0.173)		TGGCACATTACAACTTCAAGA	0.652000													6	21					0	0	1	0	0
COL4A2	1284	broad.mit.edu	37	13	111155594	111155594	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr13:111155594G>A	ENST00000360467.5	+	42	4310	c.4004G>A	c.(4003-4005)gGc>gAc	p.G1335D	COL4A2-AS1_ENST00000417970.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	1335	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			GGGCCCCAGGGCAGGCCTGGT	0.642000													12	42					0	0	1	0	0
COL10A1	1300	broad.mit.edu	37	6	116443070	116443070	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:116443070G>T	ENST00000327673.4	-	2	616	c.209C>A	c.(208-210)cCt>cAt	p.P70H	NT5DC1_ENST00000319550.4_Intron|AL121963.1_ENST00000430695.1_Missense_Mutation_p.139_139insC|COL10A1_ENST00000243222.4_Missense_Mutation_p.P70H			Q03692	COAA1_HUMAN	collagen, type X, alpha 1	70	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)|endometrium(2)|lung(6)|skin(3)|upper_aerodigestive_tract(1)	13		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		GTGCCCTCGAGGTCCAGCAGG	0.582000													41	86					8.16277e-20	1.05461e-19	1	1	0
PDE8B	8622	broad.mit.edu	37	5	76649224	76649224	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:76649224A>G	ENST00000264917.5	+	10	1205	c.1160A>G	c.(1159-1161)aAt>aGt	p.N387S	PDE8B_ENST00000346042.3_Intron|PDE8B_ENST00000333194.4_Missense_Mutation_p.N387S|PDE8B_ENST00000340978.3_Missense_Mutation_p.N340S|PDE8B_ENST00000342343.4_Missense_Mutation_p.N367S	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	387					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		ACTGACAATAATAAGCAGGTA	0.393000													23	9					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31318686	31318686	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr18:31318686G>C	ENST00000269197.5	+	11	1318	c.1318G>C	c.(1318-1320)Gag>Cag	p.E440Q		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						ATTGGAGTCAGAGGATATCTT	0.413000													5	54					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8499745	8499745	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr9:8499745C>A	ENST00000381196.4	-	22	2767	c.2224G>T	c.(2224-2226)Ggc>Tgc	p.G742C	PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000540109.1_Missense_Mutation_p.G742C|PTPRD_ENST00000360074.4_Missense_Mutation_p.G729C|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.G729C|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000471274.1_5'UTR|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000356435.5_Missense_Mutation_p.G742C|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000397611.3_Intron	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	742	Fibronectin type-III 5.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		CTTATCTGGCCATGCTGTTTA	0.512000										TSP Lung(15;0.13)			38	77					4.92203e-23	6.59999e-23	1	1	0
BCAS3	54828	broad.mit.edu	37	17	58885363	58885363	+	Splice_Site	SNP	A	A	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr17:58885363A>C	ENST00000589222.1	+	7	471		c.e7-1		BCAS3_ENST00000588462.1_Splice_Site|BCAS3_ENST00000408905.3_Splice_Site|BCAS3_ENST00000390652.5_Splice_Site|BCAS3_ENST00000407086.3_Splice_Site			Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3							nucleus				NS(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(24)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			CCTTCCTGTCAGGTGCTCAAA	0.318000													13	156					0	0	1	0	0
PCDHA3	56145	broad.mit.edu	37	5	140182652	140182652	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:140182652G>T	ENST00000522353.2	+	1	1870	c.1870G>T	c.(1870-1872)Gtg>Ttg	p.V624L	PCDHA3_ENST00000532566.2_Missense_Mutation_p.V624L|PCDHA2_ENST00000520672.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000504120.2_Intron	NM_018906.2	NP_061729.1														NS(1)|breast(1)|endometrium(16)|kidney(3)|large_intestine(19)|lung(36)|ovary(7)|prostate(8)|skin(3)|stomach(1)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCGTTTCGCGTGGGGCTGTA	0.662000													28	59					1.32181e-22	1.7591e-22	1	1	0
ELAVL2	1993	broad.mit.edu	37	9	23705016	23705016	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr9:23705016G>A	ENST00000397312.2	-	4	661	c.387C>T	c.(385-387)gtC>gtT	p.V129V	ELAVL2_ENST00000380117.1_Silent_p.V129V|ELAVL2_ENST00000544538.1_Silent_p.V129V|ELAVL2_ENST00000223951.6_Silent_p.V129V|ELAVL2_ENST00000380110.4_Silent_p.V158V	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2	129	RRM 2.				regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		GAAGTCCGCTGACATATAAAT	0.403000													6	65					0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52909845	52909845	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:52909845A>G	ENST00000391788.2	+	6	713	c.190A>G	c.(190-192)Aaa>Gaa	p.K64E	ZNF528_ENST00000594530.1_Missense_Mutation_p.K74E|ZNF528_ENST00000598192.1_Missense_Mutation_p.K74E|ZNF528_ENST00000360465.3_Missense_Mutation_p.K74E			Q3MIS6	ZN528_HUMAN	zinc finger protein 528	74	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GAGTGAAGAGAAAATAGCAAA	0.448000													10	78					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354128	57354128	+	Silent	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr8:57354128A>G	ENST00000314922.3	-	2	583	c.507T>C	c.(505-507)cgT>cgC	p.R169R	PENK_ENST00000451791.2_Silent_p.R169R|PENK_ENST00000523274.1_5'UTR	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	169					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			GGTGGTGGCTACGCTCTCGGT	0.522000													46	144					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73843311	73843311	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:73843311G>T	ENST00000342056.2	+	11	1870	c.1472G>T	c.(1471-1473)cGc>cTc	p.R491L	KCNQ5_ENST00000402622.2_Missense_Mutation_p.R482L|KCNQ5_ENST00000370398.1_Missense_Mutation_p.R472L|KCNQ5_ENST00000355635.3_Missense_Mutation_p.R473L|KCNQ5_ENST00000355194.4_Missense_Mutation_p.R472L|KCNQ5_ENST00000414165.2_Intron|KCNQ5_ENST00000403813.2_Missense_Mutation_p.R463L	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	472					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GACCGAACCCGCTTCCGGCCC	0.527000													27	60					2.65835e-16	3.31357e-16	1	1	0
NBEA	26960	broad.mit.edu	37	13	36158125	36158125	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr13:36158125A>G	ENST00000540320.1	+	46	7660	c.7126A>G	c.(7126-7128)Aat>Gat	p.N2376D	NBEA_ENST00000400445.3_Missense_Mutation_p.N2376D|NBEA_ENST00000379939.2_Missense_Mutation_p.N2373D|NBEA_ENST00000537702.1_Missense_Mutation_p.N169D|NBEA_ENST00000310336.4_Missense_Mutation_p.N2376D			Q8NFP9	NBEA_HUMAN	neurobeachin	2376	BEACH.					cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		CTACCATTATAATACCCATTA	0.388000													20	70					0	0	1	0	0
GPRASP1	9737	broad.mit.edu	37	X	101909507	101909507	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chrX:101909507T>A	ENST00000537097.1	+	6	1479	c.666T>A	c.(664-666)agT>agA	p.S222R	RP4-769N13.7_ENST00000602441.1_RNA|GPRASP1_ENST00000361600.5_Missense_Mutation_p.S222R|GPRASP1_ENST00000415986.1_Missense_Mutation_p.S222R|GPRASP1_ENST00000444152.1_Missense_Mutation_p.S222R	NM_001184727.1	NP_001171656.1	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting protein 1	222						cytoplasm	protein binding			NS(1)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TAAAAGACAGTAACAGATCCA	0.428000													7	99					0	0	1	0	0
ARL13B	200894	broad.mit.edu	37	3	93722578	93722578	+	Missense_Mutation	SNP	T	T	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:93722578T>C	ENST00000394222.3	+	3	481	c.206T>C	c.(205-207)aTc>aCc	p.I69T	ARL13B_ENST00000539730.1_Intron|ARL13B_ENST00000535334.1_5'UTR|ARL13B_ENST00000471138.1_Missense_Mutation_p.I69T|ARL13B_ENST00000303097.7_Intron|ARL13B_ENST00000486562.1_Intron	NM_001174150.1	NP_001167621.1	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 13B	69							GTP binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(2)	10						GAAGTCACCATCTTTGACTTG	0.368000													39	64					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31375061	31375061	+	Missense_Mutation	SNP	C	C	T	rs147421711		TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr20:31375061C>T	ENST00000328111.2	+	6	779	c.458C>T	c.(457-459)tCg>tTg	p.S153L	DNMT3B_ENST00000375623.4_Missense_Mutation_p.S111L|DNMT3B_ENST00000456297.2_Missense_Mutation_p.S77L|DNMT3B_ENST00000353855.2_Missense_Mutation_p.S153L|DNMT3B_ENST00000348286.2_Missense_Mutation_p.S153L|DNMT3B_ENST00000201963.3_Missense_Mutation_p.S165L|DNMT3B_ENST00000443239.3_Missense_Mutation_p.S111L|DNMT3B_ENST00000344505.4_Missense_Mutation_p.S153L	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	153	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GCAACAGCATCGGCAGGAACG	0.597000													10	111					0	0	1	0	0
CDH3	1001	broad.mit.edu	37	16	68716298	68716298	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr16:68716298G>T	ENST00000264012.4	+	9	1634	c.1090G>T	c.(1090-1092)Gcc>Tcc	p.A364S	CDH3_ENST00000581171.1_Missense_Mutation_p.A309S|CDH3_ENST00000429102.2_Missense_Mutation_p.A364S	NM_001793.4	NP_001784.2	P22223	CADH3_HUMAN	cadherin 3, type 1, P-cadherin (placental)	364	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion|response to stimulus|visual perception	integral to membrane	calcium ion binding	p.?(2)		NS(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)|ovary(3)|skin(1)|urinary_tract(1)	25		Ovarian(137;0.0564)		OV - Ovarian serous cystadenocarcinoma(108;0.000782)|Epithelial(162;0.0054)|all cancers(182;0.0384)		AGCGTGGCGTGCCACCTACCT	0.597000													10	36					7.48243e-07	8.22602e-07	1	1	0
TRPC7	57113	broad.mit.edu	37	5	135692644	135692644	+	Silent	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:135692644C>T	ENST00000513104.1	-	2	714	c.432G>A	c.(430-432)caG>caA	p.Q144Q	TRPC7_ENST00000426057.2_Silent_p.Q144Q|TRPC7_ENST00000355180.3_Silent_p.Q144Q	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	144					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CGCGCAGCTCCTGTTCCAGCG	0.657000													29	59					0	0	1	0	0
CEACAM5	1048	broad.mit.edu	37	19	42218935	42218935	+	Missense_Mutation	SNP	T	T	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:42218935T>G	ENST00000221992.6	+	3	584	c.470T>G	c.(469-471)gTg>gGg	p.V157G	CEACAM5_ENST00000398599.4_Missense_Mutation_p.V157G|CEACAM5_ENST00000405816.1_Missense_Mutation_p.V157G|CEA_ENST00000598976.1_Intron	NM_004363.2	NP_004354.2	P06731	CEAM5_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 5	157	Ig-like 2.					anchored to membrane|basolateral plasma membrane|integral to plasma membrane				breast(1)|endometrium(3)|kidney(5)|large_intestine(4)|lung(10)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	34				OV - Ovarian serous cystadenocarcinoma(3;0.00278)|all cancers(3;0.00625)|Epithelial(262;0.0379)|GBM - Glioblastoma multiforme(1328;0.142)		TCCAAACCCGTGGAGGACAAG	0.562000													57	75					0	0	1	0	0
MUT	4594	broad.mit.edu	37	6	49399492	49399492	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:49399492C>A	ENST00000274813.3	-	13	2329	c.2202G>T	c.(2200-2202)caG>caT	p.Q734H		NM_000255.3	NP_000246.2	P22033	MUTA_HUMAN	methylmalonyl CoA mutase	734	B12-binding.				fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	30	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CATCAAGCACCTGAACGGCAG	0.333000													42	106					5.44703e-19	6.9864e-19	1	1	0
ZNF181	339318	broad.mit.edu	37	19	35232520	35232520	+	Nonsense_Mutation	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:35232520A>T	ENST00000392232.3	+	6	1534	c.1366A>T	c.(1366-1368)Aaa>Taa	p.K456*	ZNF181_ENST00000492450.1_Nonsense_Mutation_p.K412*|ZNF181_ENST00000459757.1_Nonsense_Mutation_p.K411*			Q2M3W8	ZN181_HUMAN	zinc finger protein 181	412					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|skin(1)	22	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CAAATGTCTGAAAGTCTTTAG	0.383000													5	26					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18705959	18705959	+	Missense_Mutation	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:18705959A>T	ENST00000406451.3	+	12	1732	c.1582A>T	c.(1582-1584)Agg>Tgg	p.R528W	HDAC9_ENST00000417496.2_Missense_Mutation_p.R526W|HDAC9_ENST00000405010.3_Missense_Mutation_p.R528W|HDAC9_ENST00000456174.2_Missense_Mutation_p.R500W|HDAC9_ENST00000428307.2_Missense_Mutation_p.R484W|HDAC9_ENST00000524023.1_Missense_Mutation_p.R451W|HDAC9_ENST00000401921.1_Missense_Mutation_p.R487W|HDAC9_ENST00000432645.2_Missense_Mutation_p.R528W|HDAC9_ENST00000406072.1_Missense_Mutation_p.R515W|HDAC9_ENST00000441542.2_Missense_Mutation_p.R531W	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	528					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	CAACAGCACTAGGAGCGACAG	0.557000											OREG0017877	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	57					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96971761	96971761	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr10:96971761G>C	ENST00000341686.3	+	6	1007	c.882G>C	c.(880-882)atG>atC	p.M294I	C10orf129_ENST00000430183.1_Missense_Mutation_p.M139I|C10orf129_ENST00000394005.3_Missense_Mutation_p.M294I	NM_207321.2	NP_997204.2	Q6P461	ACSM6_HUMAN	chromosome 10 open reading frame 129	294					fatty acid metabolic process	mitochondrion	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		TGTGTCACATGCCAACCTTCT	0.488000													12	29					0	0	1	0	0
TTLL9	164395	broad.mit.edu	37	20	30486337	30486337	+	Missense_Mutation	SNP	C	C	T	rs143259320	by1000genomes	TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr20:30486337C>T	ENST00000375938.4	+	4	428	c.175C>T	c.(175-177)Cgc>Tgc	p.R59C	TTLL9_ENST00000375922.4_Missense_Mutation_p.R9C|TTLL9_ENST00000310998.4_Missense_Mutation_p.R9C|TTLL9_ENST00000375934.4_Missense_Mutation_p.R41C|TTLL9_ENST00000375921.2_Missense_Mutation_p.R9C|TTLL9_ENST00000535842.1_Missense_Mutation_p.R59C			Q3SXZ7	TTLL9_HUMAN	tubulin tyrosine ligase-like family, member 9	59	TTL.				protein modification process	cilium|microtubule|microtubule basal body	ATP binding|tubulin-tyrosine ligase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGACGTCCTTCGCCACAGGCC	0.522000													16	40					0	0	1	0	0
PCDH20	64881	broad.mit.edu	37	13	61986963	61986963	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr13:61986963G>A	ENST00000409186.1	-	5	3374	c.1269C>T	c.(1267-1269)ccC>ccT	p.P423P	PCDH20_ENST00000409204.4_Silent_p.P423P			Q8N6Y1	PCD20_HUMAN	protocadherin 20	396	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(14)|liver(1)|lung(23)|ovary(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	58		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		CAATTTCAGGGGGTCTGAAAA	0.443000													33	51					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156618629	156618629	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:156618629C>T	ENST00000329117.4	+	6	1375	c.1039C>T	c.(1039-1041)Cgc>Tgc	p.R347C	BCAN_ENST00000361588.5_Missense_Mutation_p.R347C|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	347	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TAAGCACAGCCGCTTCAACGT	0.577000													71	90					0	0	1	0	0
RAPGEF4	11069	broad.mit.edu	37	2	173853501	173853501	+	Silent	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:173853501C>T	ENST00000264111.6	+	14	1492	c.1305C>T	c.(1303-1305)atC>atT	p.I435I	RAPGEF4_ENST00000535187.1_Silent_p.I216I|RAPGEF4_ENST00000539331.1_Silent_p.I283I|RAPGEF4_ENST00000538974.1_Silent_p.I265I|RAPGEF4_ENST00000540783.1_Silent_p.I283I|RAPGEF4_ENST00000473043.1_3'UTR|RAPGEF4_ENST00000409036.1_Silent_p.I436I|RAPGEF4_ENST00000397081.3_Silent_p.I436I|RAPGEF4_ENST00000397087.3_Silent_p.I292I			Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	436					blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(14)|lung(13)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47			OV - Ovarian serous cystadenocarcinoma(117;0.194)			CTGCCTCTATCGTCTTACGAG	0.498000													14	61					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921522	24921522	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr15:24921522G>A	ENST00000329468.2	+	1	982	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GGTGCAGATCGAAGGGGAGGA	0.617000													16	22					0	0	1	0	0
PRDM7	11105	broad.mit.edu	37	16	90124748	90124748	+	Silent	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr16:90124748A>T	ENST00000449207.2	-	10	1447	c.1428T>A	c.(1426-1428)gcT>gcA	p.A476A	PRDM7_ENST00000325921.6_3'UTR|PRDM7_ENST00000407825.1_3'UTR	NM_001098173.1	NP_001091643.1	Q9NQW5	PRDM7_HUMAN	PR domain containing 7	476						chromosome|nucleus	nucleic acid binding			lung(2)|ovary(2)|stomach(1)	5		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TTGTCATTACAGCAGCGTGGA	0.473000													16	39					0	0	1	0	0
MFN1	55669	broad.mit.edu	37	3	179096212	179096212	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:179096212G>T	ENST00000471841.1	+	13	1539	c.1413G>T	c.(1411-1413)caG>caT	p.Q471H	MFN1_ENST00000280653.7_Intron|MFN1_ENST00000263969.5_Missense_Mutation_p.Q471H	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	471					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TAGTGCTTCAGACCCAGCAAG	0.368000													25	41					1.42536e-11	1.67078e-11	1	1	0
SRCAP	10847	broad.mit.edu	37	16	30732549	30732549	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr16:30732549G>C	ENST00000262518.4	+	21	3678	c.3293G>C	c.(3292-3294)cGg>cCg	p.R1098P	SRCAP_ENST00000344771.4_Intron|SRCAP_ENST00000395059.2_Missense_Mutation_p.R1098P	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1098	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GGGACCTCACGGCCTCCCACG	0.607000													46	78					0	0	1	0	0
CDK13	8621	broad.mit.edu	37	7	40027315	40027315	+	Silent	SNP	A	A	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:40027315A>C	ENST00000181839.4	+	2	1934	c.1329A>C	c.(1327-1329)ctA>ctC	p.L443L	CDK13_ENST00000340829.5_Silent_p.L443L	NM_003718.4|NM_031267.3	NP_003709.3|NP_112557.2	Q14004	CDK13_HUMAN	cyclin-dependent kinase 13	443					alternative nuclear mRNA splicing, via spliceosome|hemopoiesis|interspecies interaction between organisms|phosphorylation of RNA polymerase II C-terminal domain|positive regulation of cell proliferation|regulation of mitosis	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(2)|prostate(2)|skin(5)|stomach(2)|urinary_tract(1)	49						CTAGCACACTAACTCTGAAGA	0.473000													23	39					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85517978	85517978	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr12:85517978G>T	ENST00000393217.2	+	17	3749	c.3688G>T	c.(3688-3690)Gcc>Tcc	p.A1230S		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1230										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TGAATCAGAAGCCCAGAAAAA	0.418000													35	63					1.36615e-20	1.778e-20	1	1	0
PRODH2	58510	broad.mit.edu	37	19	36293143	36293143	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:36293143A>G	ENST00000301175.3	-	10	1393	c.1376T>C	c.(1375-1377)gTc>gCc	p.V459A		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	459					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCCGAAACAGACAGTCCCATC	0.547000													17	74					0	0	1	0	0
DRD3	1814	broad.mit.edu	37	3	113890705	113890705	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:113890705G>A	ENST00000383673.2	-	2	565	c.135C>T	c.(133-135)ttC>ttT	p.F45F	DRD3_ENST00000467632.1_Silent_p.F45F|DRD3_ENST00000295881.7_Silent_p.F45F|DRD3_ENST00000460779.1_Silent_p.F45F	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	45					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	GGCCATTGCCGAAGACGATGG	0.612000													5	67					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73651944	73651944	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:73651944G>T	ENST00000264448.6	+	5	1262	c.1151G>T	c.(1150-1152)aGa>aTa	p.R384I	ALMS1_ENST00000409009.1_Missense_Mutation_p.R342I|ALMS1_ENST00000377715.1_Missense_Mutation_p.R384I	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	384					G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GCTACTAAAAGAAGTGACCAT	0.373000													15	36					3.27435e-08	3.69147e-08	1	1	0
HSPH1	10808	broad.mit.edu	37	13	31713011	31713011	+	Silent	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr13:31713011C>A	ENST00000320027.5	-	16	2459	c.2115G>T	c.(2113-2115)cgG>cgT	p.R705R	HSPH1_ENST00000445273.2_Silent_p.R707R|HSPH1_ENST00000429785.2_Silent_p.R524R|HSPH1_ENST00000380405.4_Silent_p.R661R|HSPH1_ENST00000380406.5_Silent_p.R664R	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	705					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		CTTCCTGAAACCGAACTTTAA	0.333000													15	49					0.0242445	0.0249493	1	1	0
INTU	27152	broad.mit.edu	37	4	128608866	128608866	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:128608866G>T	ENST00000335251.5	+	8	1396	c.1293G>T	c.(1291-1293)ttG>ttT	p.L431F		NM_015693.3	NP_056508.2	Q9ULD6	PDZD6_HUMAN	inturned planar cell polarity protein	431										breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	43						TTCCTCGTTTGGATCATTTTT	0.443000													29	30					1.30897e-18	1.65491e-18	1	1	0
VRK1	7443	broad.mit.edu	37	14	97321560	97321560	+	Splice_Site	SNP	G	G	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr14:97321560G>C	ENST00000216639.3	+	8	725		c.e8-1			NM_003384.2	NP_003375.1	Q99986	VRK1_HUMAN	vaccinia related kinase 1							cytoplasm|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|endometrium(1)|large_intestine(5)|lung(3)|skin(1)|stomach(1)	12		Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.234)		GAAATTTATAGGTGTACTTGG	0.398000													18	37					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106815147	106815147	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr8:106815147G>T	ENST00000407775.2	+	8	3087	c.2837G>T	c.(2836-2838)aGt>aTt	p.S946I	RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.S814I|ZFPM2_ENST00000517361.1_Missense_Mutation_p.S814I|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000520594.1_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.S677I	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	946					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AAGGTCTTTAGTGAAGCTGCT	0.413000													11	28					4.84862e-15	5.91865e-15	1	1	0
BAI3	577	broad.mit.edu	37	6	70040441	70040441	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:70040441G>A	ENST00000370598.1	+	23	3900	c.3079G>A	c.(3079-3081)Gga>Aga	p.G1027R	BAI3_ENST00000238918.8_Missense_Mutation_p.G233R	NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1027					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.G1027R(2)		NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				TGCTTTTGTGGGACCTGCAGC	0.363000													7	21					0	0	1	0	0
EMR2	30817	broad.mit.edu	37	19	14854319	14854319	+	Missense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:14854319C>A	ENST00000315576.3	-	20	2827	c.2376G>T	c.(2374-2376)tgG>tgT	p.W792C	EMR2_ENST00000596991.2_Missense_Mutation_p.W781C|EMR2_ENST00000353876.1_Missense_Mutation_p.W699C|EMR2_ENST00000392967.2_Missense_Mutation_p.W781C|EMR2_ENST00000346057.1_Missense_Mutation_p.W743C|EMR2_ENST00000595839.1_Missense_Mutation_p.W650C|EMR2_ENST00000594076.1_Missense_Mutation_p.W699C|EMR2_ENST00000353005.1_Missense_Mutation_p.W650C|EMR2_ENST00000594294.1_Missense_Mutation_p.W743C|EMR2_ENST00000601345.1_Missense_Mutation_p.W781C|EMR2_ENST00000392965.3_Missense_Mutation_p.W734C	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	792					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						TCCCTTTGGACCATTTCCCAT	0.542000													35	182					2.68265e-12	3.2083e-12	1	1	0
PCDHB14	56122	broad.mit.edu	37	5	140605035	140605035	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:140605035C>T	ENST00000239449.4	+	1	1958	c.1958C>T	c.(1957-1959)tCg>tTg	p.S653L	PCDHB14_ENST00000515856.2_Missense_Mutation_p.S500L	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		653	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCCTCGCTCGGCCACCGCC	0.721000													25	85					0	0	1	0	0
GRB10	2887	broad.mit.edu	37	7	50771589	50771589	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:50771589G>A	ENST00000403097.1	-	4	830	c.50C>T	c.(49-51)aCa>aTa	p.T17I	GRB10_ENST00000402578.1_Intron|GRB10_ENST00000357271.5_Missense_Mutation_p.T23I|GRB10_ENST00000439599.1_Missense_Mutation_p.T17I|GRB10_ENST00000402497.1_5'UTR|GRB10_ENST00000406641.1_5'UTR|GRB10_ENST00000335866.3_5'UTR|GRB10_ENST00000401949.1_Missense_Mutation_p.T23I|GRB10_ENST00000398810.2_5'UTR|GRB10_ENST00000407526.1_5'UTR|GRB10_ENST00000398812.2_Missense_Mutation_p.T23I			Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10	23					insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity			NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(19)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	41	Glioma(55;0.08)|all_neural(89;0.245)					ACTGCGAGGTGTCTGCTCCAC	0.522000									Russell-Silver syndrome				7	39					0	0	1	0	0
POLRMT	5442	broad.mit.edu	37	19	622754	622754	+	Splice_Site	SNP	T	T	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:622754T>G	ENST00000588649.2	-	8	1540		c.e8-2			NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)						transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCAGGACCTGCGGAAGGCA	0.736000													3	3					0	0	1	0	0
SF3B1	23451	broad.mit.edu	37	2	198266713	198266713	+	Missense_Mutation	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:198266713C>T	ENST00000335508.5	-	15	2310	c.2219G>A	c.(2218-2220)gGa>gAa	p.G740E		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	740					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding	p.G740E(1)		NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			ATTTACCTTTCCTCTGTGTTG	0.343000			Mis		myelodysplastic syndrome								8	32					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85449626	85449626	+	Missense_Mutation	SNP	A	A	G			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr12:85449626A>G	ENST00000393217.2	+	8	1116	c.1055A>G	c.(1054-1056)cAa>cGa	p.Q352R		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	352	Glu-rich.									breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		agaaaaaagcaaaaggaagag	0.323000													7	5					0	0	1	0	0
IRF2BP2	359948	broad.mit.edu	37	1	234744400	234744400	+	Nonsense_Mutation	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:234744400C>A	ENST00000366609.3	-	1	871	c.841G>T	c.(841-843)Gag>Tag	p.E281*	RP4-781K5.2_ENST00000436039.1_RNA|IRF2BP2_ENST00000366610.3_Nonsense_Mutation_p.E281*	NM_182972.2	NP_892017.2	Q7Z5L9	I2BP2_HUMAN	interferon regulatory factor 2 binding protein 2	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	11	Ovarian(103;0.0303)	all_cancers(173;0.0236)|Prostate(94;0.0115)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)|Epithelial(3;6.2e-05)			GCGCTCAGCTCGGCGGCCCCG	0.736000													5	4					0.0215528	0.022309	1	1	0
MED28	80306	broad.mit.edu	37	4	17616277	17616277	+	Translation_Start_Site	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr4:17616277C>A	ENST00000237380.6	+	0	24					NM_025205.3	NP_079481.2	Q9H204	MED28_HUMAN	mediator complex subunit 28						regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|membrane|nucleus	actin binding			lung(6)|skin(2)	8						CCATTCCAAACATGGCGGCTC	0.652000													16	26					6.72482e-11	7.7797e-11	1	1	0
ANKRD20A1	84210	broad.mit.edu	37	9	67968442	67968442	+	Silent	SNP	A	A	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr9:67968442A>T	ENST00000377477.2	+	15	2113	c.2001A>T	c.(1999-2001)acA>acT	p.T667T		NM_032250.3	NP_115626.2			ankyrin repeat domain 20 family, member A1											kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	11						TTTCTGAAACACAAATTAAAT	0.343000													16	99					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7880257	7880257	+	Missense_Mutation	SNP	G	G	C			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:7880257G>C	ENST00000377532.3	+	14	1965	c.1741G>C	c.(1741-1743)Gac>Cac	p.D581H	PER3_ENST00000361923.2_Missense_Mutation_p.D573H|RP3-467L1.4_ENST00000451646.1_RNA			P56645	PER3_HUMAN	period circadian clock 3	573	CSNK1E binding domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CTCAGAAGAAGACAAACAGAA	0.378000													8	43					0	0	1	0	0
TBC1D15	64786	broad.mit.edu	37	12	72288604	72288604	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr12:72288604G>T	ENST00000550746.1	+	8	911	c.847G>T	c.(847-849)Gct>Tct	p.A283S	TBC1D15_ENST00000393309.3_Missense_Mutation_p.A37S|TBC1D15_ENST00000319106.8_Missense_Mutation_p.A274S|TBC1D15_ENST00000485960.2_Missense_Mutation_p.A266S	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	283							protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TCTTAGTGATGCTATTCCAGG	0.353000													10	79					0.0809354	0.0823308	1	1	0
ALDH1A1	216	broad.mit.edu	37	9	75543859	75543859	+	Missense_Mutation	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr9:75543859G>A	ENST00000297785.3	-	4	445	c.391C>T	c.(391-393)Cgc>Tgc	p.R131C	ALDH1A1_ENST00000376939.1_Missense_Mutation_p.R131C|ALDH1A1_ENST00000482210.1_5'UTR	NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	131					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GCACAGTAGCGCAATGTTTTG	0.428000													10	123					0	0	1	0	0
TGFB2	7042	broad.mit.edu	37	1	218614687	218614687	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:218614687T>A	ENST00000366929.4	+	8	1779	c.1312T>A	c.(1312-1314)Tct>Act	p.S438T	TGFB2_ENST00000479322.1_3'UTR|TGFB2_ENST00000366930.4_Missense_Mutation_p.S410T	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	410					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		GATTGTAAAGTCTTGCAAATG	0.383000													10	32					0	0	1	0	0
CDKN2B	1030	broad.mit.edu	37	9	22008887	22008887	+	Silent	SNP	C	C	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr9:22008887C>T	ENST00000276925.6	-	1	475	c.66G>A	c.(64-66)gcG>gcA	p.A22A	CDKN2B-AS1_ENST00000584020.1_RNA|CDKN2B-AS1_ENST00000580467.1_RNA|CDKN2B-AS1_ENST00000580576.1_RNA|CDKN2B-AS1_ENST00000585267.1_RNA|CDKN2B-AS1_ENST00000577551.1_RNA|CDKN2B-AS1_ENST00000582301.1_RNA|CDKN2B-AS1_ENST00000584816.1_RNA|CDKN2B_ENST00000539462.1_Silent_p.A22A|CDKN2B-AS1_ENST00000584637.1_RNA|CDKN2B-AS1_ENST00000468603.2_RNA|CDKN2B-AS1_ENST00000428597.1_RNA|CDKN2B-AS1_ENST00000584351.1_RNA|CDKN2B-AS1_ENST00000581051.1_RNA|CDKN2B-AS1_ENST00000583719.1_RNA|CDKN2B-AS1_ENST00000455933.2_RNA|CDKN2B-AS1_ENST00000582072.1_RNA|CDKN2B_ENST00000380142.4_Silent_p.A22A|RP11-145E5.5_ENST00000404796.2_Intron	NM_004936.3|NM_078487.2	NP_004927.2|NP_511042.1	P42772	CDN2B_HUMAN	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	22				SAA -> TP (in Ref. 2; AAA50282).	cell cycle arrest|cellular response to nutrient|G1 phase of mitotic cell cycle|G2/M transition of mitotic cell cycle|megakaryocyte differentiation|mitotic cell cycle G1/S transition checkpoint|negative regulation of epithelial cell proliferation|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of cyclin-dependent protein kinase activity	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|protein kinase binding	p.0(1)|p.0?(1)		lung(2)	2		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;1.31e-280)|Lung NSC(2;2.28e-131)|all_lung(2;2.11e-123)|Glioma(2;5.66e-57)|all_neural(2;3.05e-50)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;8.01e-33)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00369)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;3.29e-71)|Epithelial(2;9.08e-60)|LUSC - Lung squamous cell carcinoma(2;5.8e-46)|LUAD - Lung adenocarcinoma(2;1.43e-25)|BRCA - Breast invasive adenocarcinoma(2;5.37e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;6.92e-07)|KIRC - Kidney renal clear cell carcinoma(2;8.63e-07)|OV - Ovarian serous cystadenocarcinoma(39;0.014)|COAD - Colon adenocarcinoma(8;0.143)		GTCCCCGCGCCGCGGCGCTGG	0.697000											OREG0019127	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	22					0	0	1	0	0
ALPPL2	251	broad.mit.edu	37	2	233272676	233272676	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:233272676G>A	ENST00000295453.3	+	5	649	c.597G>A	c.(595-597)caG>caA	p.Q199Q		NM_031313.2	NP_112603.2	P10696	PPBN_HUMAN	alkaline phosphatase, placental-like 2	199					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			breast(2)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|skin(1)	13		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	CGGCCCGCCAGGAGGGGTGCC	0.682000													26	74					0	0	1	0	0
CEP170B	283638	broad.mit.edu	37	14	105353711	105353711	+	Missense_Mutation	SNP	T	T	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr14:105353711T>A	ENST00000453495.1	+	12	3366	c.3138T>A	c.(3136-3138)agT>agA	p.S1046R	CEP170B_ENST00000414716.3_Missense_Mutation_p.S1045R|CEP170B_ENST00000418279.1_Missense_Mutation_p.S975R|CEP170B_ENST00000556508.1_Missense_Mutation_p.S975R					centrosomal protein 170B																		ATTGGCCCAGTGAGGAGCGTG	0.672000													3	5					0	0	1	0	0
IGHV4-59	28392	broad.mit.edu	37	14	107083709	107083709	+	RNA	SNP	C	C	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr14:107083709C>A	ENST00000455737.1	-	0	16																											AGGTCCAGGACTCTCAGAAAG	0.493000													7	20					5.68852e-11	6.62414e-11	1	1	0
ASTN1	460	broad.mit.edu	37	1	176863926	176863926	+	Silent	SNP	G	G	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr1:176863926G>A	ENST00000367654.2	-	17	2749	c.2736C>T	c.(2734-2736)gaC>gaT	p.D912D	ASTN1_ENST00000361833.2_Silent_p.D904D|ASTN1_ENST00000367657.3_Silent_p.D904D|ASTN1_ENST00000424564.2_Silent_p.D904D			O14525	ASTN1_HUMAN	astrotactin 1	912					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GCACCTTGGGGTCTCTTTCCC	0.522000													46	84					0	0	1	0	0
IRX4	50805	broad.mit.edu	37	5	1878794	1878794	+	Missense_Mutation	SNP	G	G	T			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:1878794G>T	ENST00000505790.1	-	6	1305	c.849C>A	c.(847-849)gaC>gaA	p.D283E	IRX4_ENST00000231357.2_Missense_Mutation_p.D283E|IRX4_ENST00000513692.1_Missense_Mutation_p.D283E	NM_001278634.1	NP_001265563.1	P78413	IRX4_HUMAN	iroquois homeobox 4	283					heart development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(7)|ovary(1)|prostate(1)	10				GBM - Glioblastoma multiforme(108;0.242)		CCAGACCGCCGTCCAGGGAGT	0.706000													7	6					0.000673444	0.000705323	1	1	0
IGKV1D-33	28896	broad.mit.edu	37	2	89952842	89952842	+	RNA	DEL	C	C	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:89952842delC	ENST00000390265.2	+	0	51																											ATAGGCTGGTCGCACCCTGTG	0.607													12	17	---	---	---	---					
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cag>ca	p.QTG371del	PTPN18_ENST00000347849.3_In_Frame_Del_p.QTG264del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	371						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													4	5	---	---	---	---					
RP11-13J8.1	0	broad.mit.edu	37	2	201967218	201967218	+	RNA	DEL	G	G	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr2:201967218delG	ENST00000448256.1	+	0	628																											aaaaaaaaaagaaTTTGTTCT	0.463													3	5	---	---	---	---					
SMC4	10051	broad.mit.edu	37	3	160129830	160129830	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr3:160129830delG	ENST00000357388.3	+	6	1261	c.810delG	c.(808-810)ttfs	p.L270fs	SMC4_ENST00000344722.5_Frame_Shift_Del_p.L270fs|SMC4_ENST00000360111.2_Frame_Shift_Del_p.L270fs|SMC4_ENST00000469762.1_Frame_Shift_Del_p.L245fs|SMC4_ENST00000462787.1_Frame_Shift_Del_p.L270fs|RP11-432B6.3_ENST00000483754.1_Intron|SMC4_ENST00000470240.1_3'UTR	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	270					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTAAAGTCTTGTGTCGGAGAG	0.348													16	70	---	---	---	---					
YTHDC2	64848	broad.mit.edu	37	5	112927692	112927692	+	Splice_Site	DEL	G	G	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr5:112927692delG	ENST00000161863.4	+	28	4242		c.e28-1			NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2								ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TTTACCTACAGGGATTTTCTA	0.398													10	10	---	---	---	---					
BACH2	60468	broad.mit.edu	37	6	90660061	90660064	+	Frame_Shift_Del	DEL	GTTG	GTTG	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:90660061_90660064delGTTG	ENST00000257749.4	-	7	2468_2471	c.1761_1764delCAAC	c.(1759-1764)acfs	p.TN587fs	BACH2_ENST00000537989.1_Frame_Shift_Del_p.TN587fs|RP3-512E2.2_ENST00000413986.1_RNA|BACH2_ENST00000343122.3_Frame_Shift_Del_p.TN587fs	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	587						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		CGTCACTGGAGTTGGTTCCATAAG	0.520													27	74	---	---	---	---					
NCOA7	135112	broad.mit.edu	37	6	126176316	126176317	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr6:126176316_126176317insA	ENST00000368357.3	+	4	553_554	c.201_202insA	c.(199-204)gaaaaafs	p.EK67fs	NCOA7_ENST00000392477.2_Frame_Shift_Ins_p.EK67fs|NCOA7_ENST00000229634.9_Intron|NCOA7_ENST00000487635.1_3'UTR	NM_001199619.1|NM_001199620.1	NP_001186548.1|NP_001186549.1	Q8NI08	NCOA7_HUMAN	nuclear receptor coactivator 7	67					cell wall macromolecule catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(16)|ovary(1)|skin(1)|soft_tissue(1)|urinary_tract(2)	39				UCEC - Uterine corpus endometrioid carcinoma (4;0.0803)|GBM - Glioblastoma multiforme(226;0.0193)|all cancers(137;0.237)		TGACTGATGAGAAAAAAAAGAG	0.356													13	149	---	---	---	---					
STAG3L2	442582	broad.mit.edu	37	7	74300557	74300564	+	RNA	DEL	AGAGCTCC	AGAGCTCC	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr7:74300557_74300564delAGAGCTCC	ENST00000423186.1	-	0	573_580							P0CL84	ST3L2_HUMAN								nucleus	binding	p.E82fs*32(2)		breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						CGGCCAGTGAAGAGCTCCAGGCGTGCGG	0.572													3	6	---	---	---	---					
TP53BP1	7158	broad.mit.edu	37	15	43730566	43730582	+	Frame_Shift_Del	DEL	TTGCCTGGCTTCACAGA	TTGCCTGGCTTCACAGA	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr15:43730566_43730582delTTGCCTGGCTTCACAGA	ENST00000263801.3	-	16	3368_3384	c.3116_3132delTCTGTGAAGCCAGGCAA	c.(3115-3132)afs	p.ICEARQ1039fs	TP53BP1_ENST00000450115.2_Frame_Shift_Del_p.ICEARQ1044fs|TP53BP1_ENST00000382039.3_Frame_Shift_Del_p.ICEARQ1044fs|TP53BP1_ENST00000382044.4_Frame_Shift_Del_p.ICEARQ1044fs	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1	1039					double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		CCTCATTCTCTTGCCTGGCTTCACAGATACAGCTCAA	0.392								Other conserved DNA damage response genes					13	26	---	---	---	---					
MYH4	4622	broad.mit.edu	37	17	10359195	10359195	+	Frame_Shift_Del	DEL	G	G	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr17:10359195delG	ENST00000255381.2	-	18	2102	c.1992delC	c.(1990-1992)acfs	p.T664fs	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	664	Actin-binding (By similarity).|Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TCCTCAAGTTGGTCATCAGCT	0.408													49	57	---	---	---	---					
KRT26	353288	broad.mit.edu	37	17	38926036	38926037	+	Frame_Shift_Ins	INS	-	-	A			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr17:38926036_38926037insA	ENST00000335552.4	-	5	986_987	c.938_939insT	c.(937-939)cgafs	p.R313fs		NM_181539.4	NP_853517.2	Q7Z3Y9	K1C26_HUMAN	keratin 26	313	Coil 2.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(5)	16		Breast(137;0.00526)				GTTCTATTTCCAGGGTTTGCAG	0.421													85	43	---	---	---	---					
CD209	30835	broad.mit.edu	37	19	7810420	7810420	+	Frame_Shift_Del	DEL	C	C	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:7810420delC	ENST00000315599.7	-	4	754	c.732delG	c.(730-732)cafs	p.Q244fs	CD209_ENST00000204801.8_Frame_Shift_Del_p.Q200fs|CD209_ENST00000394161.5_Intron|CD209_ENST00000602261.1_Intron|CD209_ENST00000601951.1_Frame_Shift_Del_p.Q220fs|CD209_ENST00000394173.4_Intron|CD209_ENST00000593660.1_Intron|CD209_ENST00000593821.1_Intron|CD209_ENST00000354397.6_Frame_Shift_Del_p.Q244fs|CD209_ENST00000301357.8_Frame_Shift_Del_p.Q108fs|CD209_ENST00000315591.8_Frame_Shift_Del_p.Q220fs|CD209_ENST00000601256.1_Frame_Shift_Del_p.Q220fs	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	244	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CAGCCTTCAGCTGGGTCAGCT	0.567													7	100	---	---	---	---					
MARCH2	51257	broad.mit.edu	37	19	8491509	8491511	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:8491509_8491511delCGG	ENST00000602117.1	+	3	648_650	c.193_195delCGG	c.(193-195)del	p.R65del	MARCH2_ENST00000601283.1_Intron|MARCH2_ENST00000215555.2_In_Frame_Del_p.R65del|RP11-886P16.6_ENST00000595706.1_RNA|MARCH2_ENST00000393944.1_In_Frame_Del_p.R65del|MARCH2_ENST00000381035.4_In_Frame_Del_p.R65del			Q9P0N8	MARH2_HUMAN	membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase	65					endocytosis	cytoplasmic vesicle|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(3)|skin(1)|urinary_tract(1)	10						TCCTTTCTGCCGGATCTGCCATG	0.567													9	47	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10249172	10249188	+	Frame_Shift_Del	DEL	CGGGGAGCAAACACGTG	CGGGGAGCAAACACGTG	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chr19:10249172_10249188delCGGGGAGCAAACACGTG	ENST00000340748.4	-	34	4229_4245	c.3994_4010delCACGTGTTTGCTCCCCG	c.(3994-4011)gfs	p.HVFAPR1332fs	DNMT1_ENST00000540357.1_Frame_Shift_Del_p.HVFAPR1332fs|DNMT1_ENST00000359526.4_Frame_Shift_Del_p.HVFAPR1348fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	1332	Catalytic.|Interaction with the PRC2/EED-EZH2 complex (By similarity).				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CTGGCAGGCCCGGGGAGCAAACACGTGCAGTGGCTCC	0.659													7	51	---	---	---	---					
IKBKG	8517	broad.mit.edu	37	X	153770605	153770608	+	Frame_Shift_Del	DEL	GGGG	GGGG	-			TCGA-86-8669-01A-11D-2393-08	TCGA-86-8669-10A-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a542d171-c312-41d8-a8a6-37db886a3e28	519d3ac4-361d-4afa-8ea1-7c5d1aca7edc	g.chrX:153770605_153770608delGGGG	ENST00000369609.5	+	1	147_150	c.127_130delGGGG	c.(127-132)aafs	p.GE43fs	IKBKG_ENST00000369607.1_Intron|G6PD_ENST00000369620.2_Intron|G6PD_ENST00000393564.2_Intron|G6PD_ENST00000497281.1_Intron|G6PD_ENST00000393562.2_Intron	NM_001099856.2	NP_001093326.2	Q9Y6K9	NEMO_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0					activation of MAPK activity|induction of apoptosis|innate immune response|interspecies interaction between organisms|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|response to DNA damage stimulus|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	metal ion binding|protein domain specific binding|signal transducer activity	p.G43G(1)		endometrium(1)|lung(1)	2	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCCATCAGGTGGGGAAAGATGCTG	0.569													4	9	---	---	---	---					
