Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
RECQL5	9400	broad.mit.edu	37	17	73624501	73624501	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:73624501G>A	ENST00000317905.5	-	18	2761	c.2602C>T	c.(2602-2604)Cag>Tag	p.Q868*	RECQL5_ENST00000423245.2_Nonsense_Mutation_p.Q841*|RECQL5_ENST00000443199.2_5'UTR	NM_004259.6	NP_004250.4	O94762	RECQ5_HUMAN	RecQ protein-like 5	868					DNA recombination|DNA repair	cytoplasm|nuclear membrane|nucleolus|nucleoplasm	ATP binding|ATP-dependent helicase activity|DNA helicase activity|nucleic acid binding			breast(1)|cervix(3)|endometrium(3)|kidney(7)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	36	all_cancers(13;2.73e-08)|Breast(9;6.04e-09)|all_epithelial(9;6.79e-09)		all cancers(21;1.15e-06)|Epithelial(20;2.19e-06)|Lung(188;0.101)|LUSC - Lung squamous cell carcinoma(166;0.112)			GGCCTCTTCTGAGGCTGGCTC	0.642000								Other identified genes with known or suspected DNA repair function					7	62					0	0	1	0	0
ANO6	196527	broad.mit.edu	37	12	45796881	45796881	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:45796881G>A	ENST00000320560.8	+	14	1841	c.1639G>A	c.(1639-1641)Gag>Aag	p.E547K	ANO6_ENST00000426898.2_3'UTR|ANO6_ENST00000435642.1_Missense_Mutation_p.E547K|ANO6_ENST00000423947.3_Missense_Mutation_p.E568K|ANO6_ENST00000441606.2_Missense_Mutation_p.E529K|ANO6_ENST00000425752.2_Missense_Mutation_p.E547K	NM_001025356.2	NP_001020527.2	Q4KMQ2	ANO6_HUMAN	anoctamin 6	547					activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						GACTGATTATGAGAACAGCCT	0.348000													22	94					0	0	1	0	0
NLN	57486	broad.mit.edu	37	5	65077225	65077225	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:65077225G>C	ENST00000380985.5	+	6	977	c.799G>C	c.(799-801)Gct>Cct	p.A267P	NLN_ENST00000502464.1_Missense_Mutation_p.A163P	NM_020726.4	NP_065777.1	Q9BYT8	NEUL_HUMAN	neurolysin (metallopeptidase M3 family)	267					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		GATGGAAATGGCTTTTAATAC	0.318000													29	63					0	0	1	0	0
FAM65C	140876	broad.mit.edu	37	20	49221298	49221298	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:49221298C>T	ENST00000327979.2	-	12	1369	c.958G>A	c.(958-960)Gag>Aag	p.E320K	FAM65C_ENST00000535356.1_Missense_Mutation_p.E324K|FAM65C_ENST00000045083.2_Missense_Mutation_p.E320K			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	320										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						AGGAAGCTCTCAGTATCAAAC	0.602000													17	58					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70503824	70503824	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:70503824G>A	ENST00000310961.5	+	22	2636	c.2218G>A	c.(2218-2220)Gat>Aat	p.D740N	LRRC7_ENST00000035383.5_Missense_Mutation_p.D735N|LRRC7_ENST00000415775.2_Missense_Mutation_p.D19N			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	735						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						ACAGCCTCTTGATTCAAAGCC	0.498000													46	174					0	0	1	0	0
GPR75	10936	broad.mit.edu	37	2	54081848	54081848	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:54081848G>A	ENST00000394705.2	-	2	316	c.46C>T	c.(46-48)Ctc>Ttc	p.L16F	GPR75-ASB3_ENST00000352846.3_Intron|ASB3_ENST00000498475.2_Intron|ASB3_ENST00000406625.2_Intron	NM_006794.3	NP_006785.1	O95800	GPR75_HUMAN	G protein-coupled receptor 75	16						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GGCACATGGAGCGAGGTGGCA	0.517000													73	88					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100354668	100354668	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:100354668G>C	ENST00000273352.3	+	5	863	c.595G>C	c.(595-597)Gag>Cag	p.E199Q	GPR128_ENST00000475887.1_5'UTR	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	199					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						TGCTTCACCTGAGGTAAAACT	0.373000													14	48					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16260739	16260739	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:16260739G>A	ENST00000375759.3	+	11	8208	c.8004G>A	c.(8002-8004)ctG>ctA	p.L2668L		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	2668	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TGAATGCCCTGAAAGGCCCCG	0.572000													26	189					0	0	1	0	0
TAAR5	9038	broad.mit.edu	37	6	132910811	132910811	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:132910811G>A	ENST00000258034.2	-	1	66	c.15C>T	c.(13-15)ttC>ttT	p.F5F		NM_003967.2	NP_003958.2	O14804	TAAR5_HUMAN	trace amine associated receptor 5	5					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(9)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	32	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		CACCTTGGATGAAGACAGCTC	0.448000													21	59					0	0	1	0	0
IGHMBP2	3508	broad.mit.edu	37	11	68682452	68682452	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:68682452G>C	ENST00000255078.3	+	6	984	c.873G>C	c.(871-873)caG>caC	p.Q291H		NM_002180.2	NP_002171.2	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	291	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|liver(1)|lung(15)|ovary(2)|prostate(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			ACAGTGCCCAGATTGTTGCAG	0.572000													46	67					0	0	1	0	0
IDI2	91734	broad.mit.edu	37	10	1065765	1065765	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:1065765C>G	ENST00000277517.1	-	5	440	c.376G>C	c.(376-378)Gag>Cag	p.E126Q	GTPBP4_ENST00000360803.4_3'UTR	NM_033261.2	NP_150286.1	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	126	Nudix hydrolase.				carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	9		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		ACAATGTCCTCTGGAGAAATC	0.353000													30	84					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143081661	143081661	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:143081661C>T	ENST00000367603.2	-	9	6506	c.5764G>A	c.(5764-5766)Gac>Aac	p.D1922N	HIVEP2_ENST00000367604.1_Missense_Mutation_p.D1922N|HIVEP2_ENST00000012134.2_Missense_Mutation_p.D1922N	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1922	Asp/Glu-rich (acidic).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CCCTGGTCGTCAAAGtcatct	0.463000													19	37					0	0	1	0	0
FOXL2	668	broad.mit.edu	37	3	138665307	138665307	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:138665307C>T	ENST00000330315.3	-	1	675	c.258G>A	c.(256-258)gcG>gcA	p.A86A		NM_023067.3	NP_075555.1	P58012	FOXL2_HUMAN	forkhead box L2	86					convergent extension|DNA fragmentation involved in apoptotic nuclear change|embryonic eye morphogenesis|extraocular skeletal muscle development|female somatic sex determination|induction of apoptosis|menstruation|negative regulation of transcription, DNA-dependent|ovarian follicle development|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding			large_intestine(1)|lung(1)|ovary(333)|skin(1)	336						ACGGGAACTTCGCGATGATGT	0.592000			Mis		granulosa-cell tumour of the ovary		"""Blepharophimosis, ptosis and epicanthus inversus Types I, II; Premature ovarian failure type III"""						28	153					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75156954	75156954	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:75156954C>A	ENST00000342232.4	-	4	1755	c.1715G>T	c.(1714-1716)gGa>gTa	p.G572V	JPH1_ENST00000518195.1_5'UTR	NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	572					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			CTGGCTGGATCCATCGCCGTC	0.557000													117	169					9.53166e-59	1.1105e-58	1	1	0
SLC12A5	57468	broad.mit.edu	37	20	44673770	44673770	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:44673770C>A	ENST00000454036.1	+	12	1705	c.1629C>A	c.(1627-1629)ccC>ccA	p.P543P	SLC12A5_ENST00000539566.1_Intron|SLC12A5_ENST00000243964.3_Silent_p.P520P	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	543					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCATTGTGCCCTTCCTGCAGG	0.637000													21	86					8.10497e-08	8.51491e-08	1	1	0
PDZRN3	23024	broad.mit.edu	37	3	73651536	73651536	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:73651536C>T	ENST00000263666.4	-	3	1001	c.887G>A	c.(886-888)gGa>gAa	p.G296E	PDZRN3_ENST00000308537.4_Missense_Mutation_p.G296E	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	296	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		TTGCAGGCCTCCTTCCTTGGC	0.433000													69	187					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186101525	186101525	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:186101525G>A	ENST00000271588.4	+	86	13525	c.13296G>A	c.(13294-13296)atG>atA	p.M4432I	HMCN1_ENST00000367492.2_Missense_Mutation_p.M4432I	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4432	Ig-like C2-type 43.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AGCGCAGCATGAGTCTGACTC	0.353000													8	25					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113212469	113212469	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:113212469G>T	ENST00000401783.2	-	24	4309	c.3973C>A	c.(3973-3975)Cag>Aag	p.Q1325K	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374469.1_Missense_Mutation_p.Q1302K|SVEP1_ENST00000302728.8_Missense_Mutation_p.Q1325K	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1325	EGF-like 4; calcium-binding (Potential).				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CCCCCAACCTGGTCTTCACAG	0.478000													114	148					7.17885e-55	8.35044e-55	1	1	0
USH2A	7399	broad.mit.edu	37	1	216595651	216595651	+	Missense_Mutation	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:216595651A>G	ENST00000366943.2	-	2	414	c.28T>C	c.(28-30)Tct>Cct	p.S10P	USH2A_ENST00000307340.3_Missense_Mutation_p.S10P|USH2A_ENST00000366942.3_Missense_Mutation_p.S10P			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	10					maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AAGAAGCCAGAGCCCAATGAA	0.418000										HNSCC(13;0.011)			12	67					0	0	1	0	0
KLHL9	55958	broad.mit.edu	37	9	21334683	21334683	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:21334683C>T	ENST00000359039.4	-	1	696	c.176G>A	c.(175-177)gGa>gAa	p.G59E	KLHL9_ENST00000537938.1_Intron			Q9P2J3	KLHL9_HUMAN	kelch-like family member 9	59	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex|midbody				endometrium(9)|large_intestine(7)|lung(10)|ovary(4)|skin(2)	32				Lung(24;8.52e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.118)		GATTTCATCTCCATCACCTGG	0.423000													43	75					0	0	1	0	0
ZNF207	7756	broad.mit.edu	37	17	30688512	30688512	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:30688512C>G	ENST00000394670.4	+	6	746	c.577C>G	c.(577-579)Cag>Gag	p.Q193E	ZNF207_ENST00000577908.1_Missense_Mutation_p.Q193E|ZNF207_ENST00000321233.6_Intron|ZNF207_ENST00000342555.6_Missense_Mutation_p.Q196E|ZNF207_ENST00000341711.6_Missense_Mutation_p.Q94E|ZNF207_ENST00000394673.2_Missense_Mutation_p.Q193E	NM_001098507.1	NP_001091977.1	O43670	ZN207_HUMAN	zinc finger protein 207	184						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|lung(3)|urinary_tract(2)	10		Breast(31;0.116)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.239)			AAAATACACCCAGTCATTTTG	0.318000													14	46					0	0	1	0	0
LHX6	26468	broad.mit.edu	37	9	124976324	124976324	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:124976324C>G	ENST00000559895.1	-	4	1038	c.160G>C	c.(160-162)Gac>Cac	p.D54H	LHX6_ENST00000373755.2_Missense_Mutation_p.D241H|LHX6_ENST00000373754.2_Missense_Mutation_p.D241H|LHX6_ENST00000394319.4_Missense_Mutation_p.D270H|LHX6_ENST00000541397.2_Missense_Mutation_p.D259H|LHX6_ENST00000340587.3_Missense_Mutation_p.D270H	NM_001242335.1	NP_001229264.1	Q9UPM6	LHX6_HUMAN	LIM homeobox 6	241					cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)	8						GGGTTGTTGTCCTGCGCGAAC	0.711000													14	53					0	0	1	0	0
TIMP2	7077	broad.mit.edu	37	17	76869934	76869934	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:76869934G>C	ENST00000262768.7	-	2	496	c.198C>G	c.(196-198)atC>atG	p.I66M	TIMP2_ENST00000586057.1_De_novo_Start_InFrame|TIMP2_ENST00000585421.1_De_novo_Start_InFrame|TIMP2_ENST00000536189.2_De_novo_Start_InFrame	NM_003255.4	NP_003246.1	P16035	TIMP2_HUMAN	TIMP metallopeptidase inhibitor 2	66	NTR.						metal ion binding|metalloendopeptidase inhibitor activity	p.I66M(1)		central_nervous_system(2)	2			BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.194)			GGATCCTCTTGATAGGGTTGC	0.527000													11	137					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156646679	156646679	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:156646679C>G	ENST00000368223.3	-	1	510	c.378G>C	c.(376-378)ctG>ctC	p.L126L		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	126	Coil 1B.|Rod.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CCTGGCTACTCAGCCAGGCCC	0.731000													4	17					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33276641	33276641	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:33276641C>A	ENST00000373477.4	-	2	983	c.75G>T	c.(73-75)gaG>gaT	p.E25D		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	25					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	CCTTCAGCTTCTCTTCCCCCA	0.468000													103	575					7.79638e-53	9.05426e-53	1	1	0
NSUN3	63899	broad.mit.edu	37	3	93845109	93845109	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:93845109G>A	ENST00000314622.4	+	6	1009	c.798G>A	c.(796-798)acG>acA	p.T266T		NM_022072.3	NP_071355.1	Q9H649	NSUN3_HUMAN	NOP2/Sun domain family, member 3	266							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	18						CTACATGCACGCTTTCCAAGG	0.393000													8	54					0	0	1	0	0
COL16A1	1307	broad.mit.edu	37	1	32150129	32150129	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:32150129C>T	ENST00000373672.3	-	31	2671	c.2155G>A	c.(2155-2157)Gaa>Aaa	p.E719K	COL16A1_ENST00000373668.3_Missense_Mutation_p.E719K|COL16A1_ENST00000271069.6_Missense_Mutation_p.E718K	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	719	Triple-helical region 6 (COL6) with 1 imperfection.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		CTAACCTTTTCTCCTTTTGGC	0.617000													39	174					0	0	1	0	0
IGFALS	3483	broad.mit.edu	37	16	1842110	1842110	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:1842110G>C	ENST00000568221.1	-	2	425	c.341C>G	c.(340-342)tCa>tGa	p.S114*	IGFALS_ENST00000215539.3_Silent_p.L103L|IGFALS_ENST00000415638.3_Silent_p.L141L			P35858	ALS_HUMAN	insulin-like growth factor binding protein, acid labile subunit	479					cell adhesion|signal transduction	soluble fraction	insulin-like growth factor binding			endometrium(2)|lung(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	8						CCTGCAGGTTGAGGAAGCCCA	0.692000													5	45					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203436	140203436	+	Silent	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:140203436G>T	ENST00000529859.1	+	1	2076	c.2076G>T	c.(2074-2076)ctG>ctT	p.L692L	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Silent_p.L692L|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000378126.3_Silent_p.L692L	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCTGCCCTGGTGGATGTCA	0.682000													45	94					1.32667e-27	1.51174e-27	1	1	0
ADCYAP1R1	117	broad.mit.edu	37	7	31124942	31124942	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:31124942G>A	ENST00000304166.4	+	9	843	c.554G>A	c.(553-555)cGc>cAc	p.R185H	ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.R185H|ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.R164H|ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.R185H	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	185					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						CACTGCACACGCAACTTCATC	0.542000													37	132					0	0	1	0	0
FRG1	2483	broad.mit.edu	37	4	190873383	190873383	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:190873383G>A	ENST00000226798.4	+	3	422	c.200G>A	c.(199-201)gGa>gAa	p.G67E	FRG1_ENST00000514482.1_3'UTR	NM_004477.2	NP_004468.1	Q14331	FRG1_HUMAN	FSHD region gene 1	67					rRNA processing	Cajal body|catalytic step 2 spliceosome|nuclear speck|nucleolus		p.G67E(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|lung(11)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|urinary_tract(1)	32		all_cancers(14;1.44e-58)|all_epithelial(14;6.32e-41)|all_lung(41;8.13e-17)|Lung NSC(41;2.13e-16)|Breast(6;2.54e-06)|Melanoma(20;0.000263)|Hepatocellular(41;0.00213)|Renal(120;0.0183)|all_hematologic(60;0.0358)|Prostate(90;0.0421)|all_neural(102;0.147)		all cancers(3;1.73e-30)|Epithelial(3;5.85e-30)|OV - Ovarian serous cystadenocarcinoma(60;5.56e-15)|BRCA - Breast invasive adenocarcinoma(30;9.14e-06)|Lung(3;3.54e-05)|STAD - Stomach adenocarcinoma(60;8.83e-05)|LUSC - Lung squamous cell carcinoma(40;0.000198)|GBM - Glioblastoma multiforme(59;0.00892)|READ - Rectum adenocarcinoma(43;0.161)		ATGGATAAGGGAACCTATATA	0.383000													48	524					0	0	1	0	0
CD1E	913	broad.mit.edu	37	1	158325349	158325349	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:158325349G>A	ENST00000444681.2	+	2	611	c.318G>A	c.(316-318)ctG>ctA	p.L106L	CD1E_ENST00000368160.3_Silent_p.L205L|CD1E_ENST00000368167.3_Silent_p.L205L|CD1E_ENST00000368154.1_Intron|CD1E_ENST00000368156.1_Intron|CD1E_ENST00000368155.3_Intron|CD1E_ENST00000434258.1_Silent_p.L203L|CD1E_ENST00000368161.3_Silent_p.L205L|CD1E_ENST00000368163.3_Silent_p.L205L|CD1E_ENST00000452291.2_Intron|CD1E_ENST00000368165.3_Intron|CD1E_ENST00000368157.1_Intron|CD1E_ENST00000368166.3_Intron|CD1E_ENST00000368164.3_Intron	NM_001185114.1	NP_001172043.1	P15812	CD1E_HUMAN	CD1e molecule	205			Q -> R (in allele CD1E*02, allele CD1E*05 and CD1E*06; dbSNP:rs1065457).		antigen processing and presentation|immune response	early endosome|Golgi membrane|integral to plasma membrane|late endosome|lysosomal lumen				breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(27)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|urinary_tract(1)	49	all_hematologic(112;0.0378)					AGTCAGAACTGAAACGGAAAG	0.448000													5	53					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112608231	112608231	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:112608231C>T	ENST00000550722.1	-	69	11915	c.11520G>A	c.(11518-11520)gtG>gtA	p.V3840V	HECTD4_ENST00000430131.2_Silent_p.V3564V|HECTD4_ENST00000377560.5_Silent_p.V3814V	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TCATCACGGTCACCTTCGTGT	0.587000											OREG0022132	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	73					0	0	1	0	0
PPP1R3D	5509	broad.mit.edu	37	20	58514177	58514177	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:58514177G>C	ENST00000370996.3	-	1	1175	c.810C>G	c.(808-810)aaC>aaG	p.N270K	FAM217B_ENST00000358293.3_Intron	NM_006242.3	NP_006233.1	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	270	CBM21.				glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|urinary_tract(1)	13	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			CTCGGTGGTCGTTGTTGTCCC	0.647000													19	92					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13871085	13871085	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:13871085C>T	ENST00000265104.4	-	24	3729	c.3625G>A	c.(3625-3627)Gag>Aag	p.E1209K	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1209	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GCCTTTGTCTCAGCAGTCAGG	0.393000									Kartagener syndrome				12	103					0	0	1	0	0
SNED1	25992	broad.mit.edu	37	2	241969721	241969721	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:241969721C>G	ENST00000310397.8	+	2	234	c.234C>G	c.(232-234)atC>atG	p.I78M	SNED1_ENST00000405547.3_Missense_Mutation_p.I78M|AC005237.4_ENST00000458377.1_RNA|SNED1_ENST00000401884.1_Missense_Mutation_p.I78M|SNED1_ENST00000342631.6_Missense_Mutation_p.I78M	NM_001080437.1	NP_001073906.1	Q8TER0	SNED1_HUMAN	sushi, nidogen and EGF-like domains 1	78					cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		ACGGGATCATCTCCTTCCTGA	0.642000													5	21					0	0	1	0	0
FBN3	84467	broad.mit.edu	37	19	8200962	8200962	+	Missense_Mutation	SNP	C	C	T	rs143434557	byFrequency	TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:8200962C>T	ENST00000600128.1	-	13	1888	c.1474G>A	c.(1474-1476)Gag>Aag	p.E492K	FBN3_ENST00000601739.1_Missense_Mutation_p.E492K|FBN3_ENST00000270509.2_Missense_Mutation_p.E492K			Q75N90	FBN3_HUMAN	fibrillin 3	492	EGF-like 5; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						ACAATGCACTCGTCCACATCT	0.607000													3	53					0	0	1	0	0
CDKN2A	1029	broad.mit.edu	37	9	21971108	21971108	+	Missense_Mutation	SNP	C	C	T	rs11552822		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:21971108C>T	ENST00000579755.1	-	2	585	c.293G>A	c.(292-294)cGa>cAa	p.R98Q	CDKN2A_ENST00000494262.1_Missense_Mutation_p.D33N|CDKN2A_ENST00000498124.1_Missense_Mutation_p.D84N|RP11-145E5.5_ENST00000404796.2_Intron|CDKN2A_ENST00000578845.2_Missense_Mutation_p.D33N|CDKN2A_ENST00000361570.3_Missense_Mutation_p.R139Q|CDKN2A_ENST00000579122.1_Missense_Mutation_p.D84N|CDKN2A_ENST00000498628.2_Missense_Mutation_p.D33N|CDKN2A_ENST00000479692.2_Missense_Mutation_p.D33N|CDKN2A_ENST00000530628.2_Missense_Mutation_p.R98Q|CDKN2A_ENST00000304494.5_Missense_Mutation_p.D84N|CDKN2A_ENST00000497750.1_Missense_Mutation_p.D33N|CDKN2A_ENST00000446177.1_Missense_Mutation_p.D84N			P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A	0			H -> P (in CMM2).|H -> Q (in CMM2).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein kinase binding	p.0?(1315)|p.?(44)|p.D84Y(11)|p.D84N(7)|p.D84fs*63(2)|p.D84H(2)|p.H83fs*2(2)|p.R139Q(2)|p.D84fs*1(1)|p.D84_F90del(1)|p.R139L(1)|p.0(1)|p.V82_G89>G(1)|p.E61_L94del(1)|p.R137fs*48(1)|p.A68fs*3(1)|p.P81_A85del(1)|p.R80fs*34(1)|p.V82_E88del(1)		NS(28)|adrenal_gland(6)|autonomic_ganglia(11)|biliary_tract(74)|bone(84)|breast(46)|central_nervous_system(522)|cervix(23)|endometrium(14)|eye(4)|genital_tract(15)|haematopoietic_and_lymphoid_tissue(698)|kidney(39)|large_intestine(11)|liver(92)|lung(365)|meninges(18)|oesophagus(239)|ovary(98)|pancreas(263)|pleura(94)|prostate(13)|salivary_gland(10)|skin(541)|small_intestine(1)|soft_tissue(93)|stomach(48)|thymus(4)|thyroid(24)|upper_aerodigestive_tract(436)|urinary_tract(283)|vulva(2)	4199		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGGGCAGCGTCGTGCACGGGT	0.741000	D84Y(DU145_PROSTATE)|D84Y(LK2_LUNG)	17								HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			8	26					0	0	1	0	0
GAS2L2	246176	broad.mit.edu	37	17	34072251	34072251	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:34072251C>T	ENST00000254466.6	-	6	2292	c.2265G>A	c.(2263-2265)ctG>ctA	p.L755L	GAS2L2_ENST00000587565.1_Silent_p.L739L	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	755					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGCCCTTGCTCAGACATGCCT	0.627000													68	177					0	0	1	0	0
ZNF7	7553	broad.mit.edu	37	8	146067424	146067424	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:146067424G>A	ENST00000528372.1	+	5	1172	c.932G>A	c.(931-933)tGt>tAt	p.C311Y	ZNF7_ENST00000325217.5_Intron|ZNF7_ENST00000525266.1_Intron|ZNF7_ENST00000325241.6_Missense_Mutation_p.C311Y|ZNF7_ENST00000446747.2_Missense_Mutation_p.C322Y|ZNF7_ENST00000544249.1_Missense_Mutation_p.C215Y			P17097	ZNF7_HUMAN	zinc finger protein 7	311					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(6)|ovary(5)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		TGTGAGGAATGTGGAAAAGCT	0.488000													53	118					0	0	1	0	0
SALL1	6299	broad.mit.edu	37	16	51185080	51185080	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:51185080C>T	ENST00000251020.4	-	1	106	c.73G>A	c.(73-75)Gat>Aat	p.D25N	SALL1_ENST00000562674.1_5'UTR|SALL1_ENST00000566102.1_Missense_Mutation_p.D25N|SALL1_ENST00000541611.1_5'UTR	NM_002968.2	NP_002959.2	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	25					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CACTCACCATCTCGCCGGGGG	0.657000													10	14					0	0	1	0	0
ACSL1	2180	broad.mit.edu	37	4	185687869	185687869	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:185687869C>T	ENST00000515030.1	-	13	1495	c.1170G>A	c.(1168-1170)ttG>ttA	p.L390L	ACSL1_ENST00000504342.1_Silent_p.L390L|ACSL1_ENST00000454703.2_Silent_p.L219L|ACSL1_ENST00000437665.3_Silent_p.L219L|ACSL1_ENST00000513317.1_Silent_p.L390L|ACSL1_ENST00000281455.2_Silent_p.L390L|ACSL1_ENST00000507295.1_Silent_p.L356L			P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	390					digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|liver(1)|lung(17)|ovary(2)|prostate(1)|skin(2)	38		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	AGGCAAAGTCCAAGAGCCATC	0.493000													27	191					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86039056	86039056	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:86039056C>T	ENST00000414626.2	+	8	2234	c.1345C>T	c.(1345-1347)Cta>Tta	p.L449L	LRRCC1_ENST00000360375.3_Silent_p.L469L			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	469					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						TAGTCTGGCTCTACTTACCAC	0.348000													14	75					0	0	1	0	0
POU2F1	5451	broad.mit.edu	37	1	167334802	167334802	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:167334802C>G	ENST00000367862.5	+	3	428	c.193C>G	c.(193-195)Cag>Gag	p.Q65E	POU2F1_ENST00000452019.1_Missense_Mutation_p.Q53E|POU2F1_ENST00000420254.3_Missense_Mutation_p.Q53E|POU2F1_ENST00000429375.2_Missense_Mutation_p.Q76E|POU2F1_ENST00000367866.2_Missense_Mutation_p.Q76E|POU2F1_ENST00000541643.3_Missense_Mutation_p.Q53E|POU2F1_ENST00000367865.1_3'UTR	NM_001198783.1	NP_001185712.1	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	53					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(3)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	30						ACATCTCCATCAGGTAGGAAT	0.488000													11	63					0	0	1	0	0
ALDOA	226	broad.mit.edu	37	16	30080846	30080846	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:30080846G>C	ENST00000566897.1	+	10	1803	c.651G>C	c.(649-651)ctG>ctC	p.L217L	ALDOA_ENST00000569798.1_Silent_p.L217L|ALDOA_ENST00000569545.1_Silent_p.L217L|ALDOA_ENST00000564546.1_Silent_p.L217L|ALDOA_ENST00000395248.1_Silent_p.L271L|ALDOA_ENST00000563060.2_Silent_p.L217L|ALDOA_ENST00000412304.2_Silent_p.L217L|ALDOA_ENST00000338110.5_Silent_p.L217L|ALDOA_ENST00000395240.3_Silent_p.L221L|ALDOA_ENST00000564595.2_Silent_p.L271L			P04075	ALDOA_HUMAN	aldolase A, fructose-bisphosphate	217					actin filament organization|ATP biosynthetic process|fructose 1,6-bisphosphate metabolic process|gluconeogenesis|glycolysis|muscle cell homeostasis|platelet activation|platelet degranulation|protein homotetramerization|regulation of cell shape|striated muscle contraction	actin cytoskeleton|cytosol|extracellular vesicular exosome|I band|platelet alpha granule lumen	actin binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding|tubulin binding			breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(6)|prostate(2)|upper_aerodigestive_tract(1)	17						ACAAGGCTCTGAGTGACCACC	0.597000											OREG0023729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	137					0	0	1	0	0
NHLRC4	283948	broad.mit.edu	37	16	618066	618066	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:618066C>A	ENST00000424439.2	+	2	676	c.19C>A	c.(19-21)Ccc>Acc	p.P7T	NHLRC4_ENST00000540585.1_Missense_Mutation_p.P7T|PIGQ_ENST00000409527.2_Intron			P0CG21	NHLC4_HUMAN	NHL repeat containing 4	7																	TCTGGAGGGCCCCTGCTGGGT	0.672000													12	21					7.03913e-09	7.47072e-09	1	1	0
ATAD3B	83858	broad.mit.edu	37	1	1420549	1420549	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:1420549C>T	ENST00000308647.7	+	8	1020	c.904C>T	c.(904-906)Cag>Tag	p.Q302*		NM_031921.4	NP_114127.3	Q5T9A4	ATD3B_HUMAN	ATPase family, AAA domain containing 3B	302							ATP binding|nucleoside-triphosphatase activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(2)|urinary_tract(1)	10	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GCACCCCATCCAGGTAGCGGC	0.687000													7	69					0	0	1	0	0
GPAM	57678	broad.mit.edu	37	10	113915700	113915700	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:113915700G>A	ENST00000348367.4	-	20	2430	c.2233C>T	c.(2233-2235)Cct>Tct	p.P745S	GPAM_ENST00000369425.1_3'UTR|GPAM_ENST00000423155.1_Missense_Mutation_p.P745S			Q9HCL2	GPAT1_HUMAN	glycerol-3-phosphate acyltransferase, mitochondrial	745					phospholipid biosynthetic process|triglyceride biosynthetic process	integral to membrane|mitochondrial outer membrane	glycerol-3-phosphate O-acyltransferase activity			breast(2)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Epithelial(162;0.0306)|all cancers(201;0.123)		TCTGGAACAGGACCACTGAAG	0.428000													23	63					0	0	1	0	0
RGS11	8786	broad.mit.edu	37	16	320551	320551	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:320551G>A	ENST00000397770.3	-	15	1194	c.1177C>T	c.(1177-1179)Cag>Tag	p.Q393*	RGS11_ENST00000359740.5_Nonsense_Mutation_p.Q382*|RGS11_ENST00000316163.5_Nonsense_Mutation_p.Q372*|ARHGDIG_ENST00000464609.1_Intron			O94810	RGS11_HUMAN	regulator of G-protein signaling 11	393	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(1)|kidney(1)|lung(4)|ovary(1)|pancreas(1)	8		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				ATGTGCAGCTGGGCGTCATCC	0.662000													7	28					0	0	1	0	0
RAB17	64284	broad.mit.edu	37	2	238483689	238483689	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:238483689C>T	ENST00000264601.3	-	6	1241	c.612G>A	c.(610-612)gcG>gcA	p.A204A	RAB17_ENST00000409576.1_Intron|RAB17_ENST00000409822.1_Silent_p.A77A|RAB17_ENST00000538644.1_Silent_p.A77A	NM_022449.3	NP_071894.1	Q9H0T7	RAB17_HUMAN	RAB17, member RAS oncogene family	204					protein transport|small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|lung(1)	4		Renal(207;0.00272)|Breast(86;0.00297)|all_hematologic(139;0.182)|Ovarian(221;0.221)		Epithelial(121;9.36e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.26e-10)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000354)|Lung(119;0.011)|LUSC - Lung squamous cell carcinoma(224;0.026)		TGGCCTGCCTCGCGGGCCCCT	0.642000													12	46					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	30944122	30944122	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:30944122G>T	ENST00000597505.1	-	22	3060	c.3061C>A	c.(3061-3063)Caa>Aaa	p.Q1021K	DCDC1_ENST00000406071.2_5'UTR|DCDC1_ENST00000339794.5_Missense_Mutation_p.Q100K			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					AGGAATATTTGTTTCTTTTGC	0.353000													11	57					0.010729	0.0108484	1	1	0
NXPH1	30010	broad.mit.edu	37	7	8790884	8790884	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:8790884C>T	ENST00000405863.1	+	3	1212	c.301C>T	c.(301-303)Cgg>Tgg	p.R101W	NXPH1_ENST00000602349.1_5'UTR|NXPH1_ENST00000497400.1_3'UTR	NM_152745.2	NP_689958.1	P58417	NXPH1_HUMAN	neurexophilin 1	101	III.					extracellular region				breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(7)|ovary(1)	17		Ovarian(82;0.0628)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)		TCAAGAGCCTCGGCCCAGGGC	0.473000													18	78					0	0	1	0	0
PRPF40B	25766	broad.mit.edu	37	12	50037093	50037093	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:50037093G>A	ENST00000261897.1	+	22	2742	c.2191G>A	c.(2191-2193)Gag>Aag	p.E731K	FMNL3_ENST00000335154.5_3'UTR|PRPF40B_ENST00000548825.2_Missense_Mutation_p.E765K|PRPF40B_ENST00000380281.1_Missense_Mutation_p.E744K			Q6NWY9	PR40B_HUMAN	PRP40 pre-mRNA processing factor 40 homolog B (S. cerevisiae)	744					mRNA processing|RNA splicing	nuclear speck				breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	34						GTCAGGCTCTGAGCCCTCTTC	0.612000													39	168					0	0	1	0	0
RNF141	50862	broad.mit.edu	37	11	10552261	10552261	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:10552261G>A	ENST00000265981.2	-	3	323	c.181C>T	c.(181-183)Ctc>Ttc	p.L61F	RNF141_ENST00000528665.1_Missense_Mutation_p.L61F	NM_016422.3	NP_057506.2	Q8WVD5	RN141_HUMAN	ring finger protein 141	61							zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(3)|urinary_tract(1)	9				all cancers(16;4.63e-08)|Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.064)		ACCTCAAAGAGAAGATGTTTT	0.398000													18	154					0	0	1	0	0
KIF4B	285643	broad.mit.edu	37	5	154394241	154394241	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:154394241C>T	ENST00000435029.4	+	1	982	c.822C>T	c.(820-822)atC>atT	p.I274I		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	274	Kinesin-motor.				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GAAATGTAATCAGTGCTCTTG	0.453000													21	165					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25168501	25168501	+	RNA	SNP	G	G	A	rs4770716	by1000genomes	TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:25168501G>A	ENST00000453498.1	+	0	1173																											TTTTCTCTTCGGTGAGTAATC	0.388000													3	47					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100373441	100373441	+	RNA	SNP	A	A	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:100373441A>C	ENST00000542585.1	+	0	6323				ZAN_ENST00000546213.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AATCCCCACAACCTACTATGG	0.527000													11	35					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45810874	45810874	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr21:45810874G>A	ENST00000397928.1	+	10	1851	c.1406G>A	c.(1405-1407)cGc>cAc	p.R469H	TRPM2_ENST00000300482.5_Missense_Mutation_p.R469H|TRPM2_ENST00000300481.9_Missense_Mutation_p.R469H|TRPM2_ENST00000397932.2_Missense_Mutation_p.R469H|TRPM2_ENST00000498430.1_3'UTR	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	469						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity	p.R469H(1)		breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						GACATTGCCCGCAGTGAGATC	0.572000													4	213					0	0	1	0	0
CEP104	9731	broad.mit.edu	37	1	3754084	3754084	+	Splice_Site	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:3754084C>G	ENST00000378230.3	-	9	1216		c.e9-1			NM_014704.3	NP_055519.1	O60308	CE104_HUMAN	centrosomal protein 104kDa							centriole	binding			breast(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(14)|lung(8)|prostate(1)|skin(3)	39						GTCTTCGCATCTAGAGAACAA	0.458000													12	40					0	0	1	0	0
NELFCD	51497	broad.mit.edu	37	20	57566100	57566100	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:57566100C>T	ENST00000602795.1	+	8	1026	c.978C>T	c.(976-978)ttC>ttT	p.F326F	NELFCD_ENST00000344018.3_Silent_p.F317F					negative elongation factor complex member C/D																		TCAAGATGTTCACAAGCATGG	0.547000													34	137					0	0	1	0	0
ZNF763	284390	broad.mit.edu	37	19	12088997	12088997	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:12088997G>T	ENST00000343949.5	+	4	422	c.267G>T	c.(265-267)caG>caT	p.Q89H	ZNF763_ENST00000590798.1_Missense_Mutation_p.Q106H|ZNF763_ENST00000358987.3_Missense_Mutation_p.Q86H|ZNF763_ENST00000592625.1_3'UTR|ZNF763_ENST00000591944.1_3'UTR|ZNF763_ENST00000545530.1_5'UTR|ZNF763_ENST00000538752.1_Missense_Mutation_p.Q106H	NM_001012753.1	NP_001012771.1			zinc finger protein 763											central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)	15						CTTTTACCCAGGTTCCAGATG	0.398000													43	184					4.44401e-20	4.9858e-20	1	1	0
ARHGEF18	23370	broad.mit.edu	37	19	7506895	7506895	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:7506895G>C	ENST00000359920.6	+	3	1006	c.753G>C	c.(751-753)aaG>aaC	p.K251N	ARHGEF18_ENST00000319670.9_Missense_Mutation_p.K93N|CTD-2207O23.3_ENST00000593531.1_Missense_Mutation_p.R209T	NM_001130955.1	NP_001124427.1	Q6ZSZ5	ARHGI_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 18	251					actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell shape|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	23		Renal(5;0.0902)				CCTACGCCAAGAAGCAAAAGA	0.572000													68	261					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184290555	184290555	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:184290555G>T	ENST00000330394.2	+	3	899	c.447G>T	c.(445-447)tgG>tgT	p.W149C	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	149						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			CCCCCTTCTGGATGGAGAACC	0.602000													25	155					5.35047e-06	5.5648e-06	1	1	0
CCDC41	51134	broad.mit.edu	37	12	94805587	94805587	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:94805587G>A	ENST00000397809.5	-	4	759	c.210C>T	c.(208-210)ctC>ctT	p.L70L	CCDC41_ENST00000547575.1_Silent_p.L70L|CCDC41_ENST00000339839.5_Silent_p.L70L|CCDC41_ENST00000397807.2_Silent_p.L37L	NM_016122.2	NP_057206.2	Q9Y592	CCD41_HUMAN	coiled-coil domain containing 41	62			Q -> R (in dbSNP:rs2271979).							breast(1)|central_nervous_system(3)|kidney(3)|large_intestine(8)|lung(8)|prostate(2)|skin(2)	27						ACAGGTGCTTGAGTTCATTTT	0.313000													13	63					0	0	1	0	0
WDR11	55717	broad.mit.edu	37	10	122668120	122668120	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:122668120C>T	ENST00000263461.6	+	29	3816	c.3570C>T	c.(3568-3570)ctC>ctT	p.L1190L	WDR11_ENST00000604509.1_3'UTR	NM_018117.11	NP_060587.8	Q9BZH6	WDR11_HUMAN	WD repeat domain 11	1190						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(9)|prostate(2)|skin(2)|stomach(5)	38						TGAAGAACCTCGGTTTTAAGC	0.438000													33	100					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154412548	154412548	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:154412548C>A	ENST00000414028.2	+	3	1155	c.1105C>A	c.(1105-1107)Cgt>Agt	p.R369S	OPRM1_ENST00000522555.1_Missense_Mutation_p.R269S|OPRM1_ENST00000452687.2_Missense_Mutation_p.R369S|OPRM1_ENST00000337049.4_Missense_Mutation_p.R369S|OPRM1_ENST00000419506.2_Missense_Mutation_p.R369S|OPRM1_ENST00000360422.4_Missense_Mutation_p.R369S|OPRM1_ENST00000434900.2_Missense_Mutation_p.R462S|OPRM1_ENST00000330432.7_Missense_Mutation_p.R369S|OPRM1_ENST00000522236.1_Missense_Mutation_p.R269S|OPRM1_ENST00000524163.1_Missense_Mutation_p.R369S|OPRM1_ENST00000520708.1_Missense_Mutation_p.R269S|OPRM1_ENST00000518759.1_Missense_Mutation_p.R288S|OPRM1_ENST00000229768.5_Missense_Mutation_p.R369S|OPRM1_ENST00000428397.2_Missense_Mutation_p.R369S|OPRM1_ENST00000435918.2_Missense_Mutation_p.R369S	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	369					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding	p.R369C(4)|p.R462C(2)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	CACTCGAATTCGTCAGAACAC	0.438000													23	65					4.26978e-12	4.61237e-12	1	1	0
GCK	2645	broad.mit.edu	37	7	44187288	44187288	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:44187288C>A	ENST00000403799.3	-	7	1293	c.824G>T	c.(823-825)cGc>cTc	p.R275L	GCK_ENST00000437084.1_Missense_Mutation_p.R258L|GCK_ENST00000395796.3_Missense_Mutation_p.R274L|GCK_ENST00000345378.2_Missense_Mutation_p.R276L	NM_000162.3	NP_000153.1	P35557	HXK4_HUMAN	glucokinase (hexokinase 4)	275					cellular response to insulin stimulus|cellular response to leptin stimulus|detection of glucose|endocrine pancreas development|glucose homeostasis|glucose transport|glycolysis|negative regulation of gluconeogenesis|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|regulation of glucose transport|regulation of glycolysis|transmembrane transport	cytosol|nucleoplasm	ATP binding|glucokinase activity|glucose binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	37						GTCCACCAGGCGGTCATACTC	0.677000													70	77					9.98788e-38	1.15074e-37	1	1	0
NRP1	8829	broad.mit.edu	37	10	33496558	33496558	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:33496558C>T	ENST00000265371.4	-	11	2226	c.1701G>A	c.(1699-1701)gaG>gaA	p.E567E	NRP1_ENST00000374816.3_Silent_p.E567E|NRP1_ENST00000374821.5_Silent_p.E567E|NRP1_ENST00000374822.4_Silent_p.E567E|NRP1_ENST00000374823.5_Silent_p.E567E|NRP1_ENST00000374867.2_Silent_p.E567E|NRP1_ENST00000466932.1_Intron|NRP1_ENST00000395995.1_Silent_p.E567E			O14786	NRP1_HUMAN	neuropilin 1	567	F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	48					Palifermin(DB00039)|Pegaptanib(DB04895)	GAGTGGCTCTCTCGGGGTAGA	0.493000													56	253					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121457760	121457760	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:121457760C>T	ENST00000305949.1	+	1	95	c.50C>T	c.(49-51)tCg>tTg	p.S17L		NM_022045.3	NP_071328.2	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa	17					cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AAATTCCCGTCGGCGGCCAGT	0.587000													46	157					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7521996	7521996	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:7521996C>G	ENST00000313599.3	-	15	4053	c.3996G>C	c.(3994-3996)caG>caC	p.Q1332H	CD163L1_ENST00000396630.1_Missense_Mutation_p.Q1332H|CD163L1_ENST00000416109.2_Missense_Mutation_p.Q1342H			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1332	SRCR 12.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CACAGTCACTCTGTCCCCAGG	0.512000													22	256					0	0	1	0	0
ZNF575	284346	broad.mit.edu	37	19	44038585	44038585	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:44038585G>A	ENST00000458714.2	+	4	1115	c.308G>A	c.(307-309)cGa>cAa	p.R103Q	ZNF575_ENST00000314228.5_Missense_Mutation_p.R4Q|ZNF575_ENST00000601282.1_Missense_Mutation_p.R4Q			Q86XF7	ZN575_HUMAN	zinc finger protein 575	4					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|lung(1)|prostate(1)|urinary_tract(1)	4		Prostate(69;0.0199)				ATGCTGGAGCGAGGCGCGGAG	0.657000													5	10					0	0	1	0	0
FCHO2	115548	broad.mit.edu	37	5	72374089	72374089	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:72374089G>C	ENST00000430046.2	+	22	2046	c.1930G>C	c.(1930-1932)Gag>Cag	p.E644Q	FCHO2_ENST00000341845.6_Missense_Mutation_p.E644Q|FCHO2_ENST00000512348.1_Missense_Mutation_p.E611Q	NM_001146032.1|NM_138782.2	NP_001139504.1|NP_620137.2	Q0JRZ9	FCHO2_HUMAN	FCH domain only 2	644										cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(1)	17		Lung NSC(167;0.0465)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;4.6e-53)		GAAGCTGTCAGAGCAAAATCC	0.313000													3	9					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141113914	141113914	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:141113914C>T	ENST00000389484.3	-	75	12498	c.11527G>A	c.(11527-11529)Gaa>Aaa	p.E3843K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3843	EGF-like 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ACTCTACCTTCACATTGTCTG	0.358000										TSP Lung(27;0.18)			23	80					0	0	1	0	0
MITD1	129531	broad.mit.edu	37	2	99797427	99797427	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:99797427C>G	ENST00000289359.2	-	1	94	c.18G>C	c.(16-18)ctG>ctC	p.L6L	MRPL30_ENST00000410042.1_Intron	NM_138798.1	NP_620153.1	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport, domain containing 1	6					protein transport	late endosome membrane				large_intestine(3)|lung(2)|ovary(1)	6						GGTCCTGCCTCAGCCCGGACT	0.582000													13	84					0	0	1	0	0
GGNBP2	79893	broad.mit.edu	37	17	34945659	34945659	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:34945659G>A	ENST00000304718.4	+	14	2228	c.1912G>A	c.(1912-1914)Gat>Aat	p.D638N		NM_024835.3	NP_079111.1	Q9H3C7	GGNB2_HUMAN	gametogenetin binding protein 2	638					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)	38		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		ATGTACTTCAGATGAGGAAAT	0.348000													25	235					0	0	1	0	0
ERAP1	51752	broad.mit.edu	37	5	96139402	96139402	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:96139402G>A	ENST00000296754.3	-	2	485	c.228C>T	c.(226-228)ttC>ttT	p.F76F	ERAP1_ENST00000443439.2_Silent_p.F76F	NM_016442.3	NP_057526.3	Q9NZ08	ERAP1_HUMAN	endoplasmic reticulum aminopeptidase 1	76					angiogenesis|antigen processing and presentation of endogenous peptide antigen via MHC class I|fat cell differentiation|membrane protein ectodomain proteolysis|regulation of blood pressure|regulation of innate immune response|response to bacterium	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region|integral to membrane	aminopeptidase activity|interleukin-1, Type II receptor binding|interleukin-6 receptor binding|metalloexopeptidase activity|zinc ion binding			endometrium(7)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|stomach(2)	19		all_cancers(142;1.75e-06)|all_epithelial(76;3.08e-09)|all_lung(232;0.000435)|Lung NSC(167;0.000601)|Ovarian(225;0.024)|Colorectal(57;0.0432)|Breast(839;0.244)		all cancers(79;7.26e-15)|COAD - Colon adenocarcinoma(37;0.071)		TGGTTCCCCAGAAGGTCAGCG	0.493000													46	108					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58604887	58604887	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:58604887G>C	ENST00000267485.7	-	2	1384	c.1190C>G	c.(1189-1191)tCc>tGc	p.S397C	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	397						integral to membrane	binding	p.S397F(1)		breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						GGGGGTAAAGGAACTTTGATC	0.512000													40	167					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	19967961	19967961	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:19967961G>T	ENST00000396085.1	+	9	2522	c.2161G>T	c.(2161-2163)Gct>Tct	p.A721S	NAV2_ENST00000540292.1_Missense_Mutation_p.A675S|NAV2_ENST00000349880.4_Missense_Mutation_p.A721S|NAV2_ENST00000360655.4_Missense_Mutation_p.A657S|NAV2_ENST00000527559.2_Missense_Mutation_p.A673S|NAV2_ENST00000396087.3_Missense_Mutation_p.A744S	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	744						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						AGATCCTGAGGCTCGGCGGCT	0.483000													10	19					0.00010058	0.000103279	1	1	0
ZNF230	7773	broad.mit.edu	37	19	44514964	44514964	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:44514964G>T	ENST00000429154.2	+	5	1001	c.773G>T	c.(772-774)gGg>gTg	p.G258V		NM_006300.3	NP_006291.2	Q9UIE0	ZN230_HUMAN	zinc finger protein 230	258					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)|stomach(3)|urinary_tract(2)	22		Prostate(69;0.0352)				GAGAAATGTGGGAGGGCCTTC	0.413000													37	177					5.04308e-16	5.54662e-16	1	1	0
CACNB3	784	broad.mit.edu	37	12	49217131	49217131	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:49217131C>G	ENST00000301050.2	+	2	249	c.50C>G	c.(49-51)tCa>tGa	p.S17*	CACNB3_ENST00000547230.1_Nonsense_Mutation_p.S17*|CACNB3_ENST00000540990.1_Nonsense_Mutation_p.S4*|CACNB3_ENST00000536187.2_Nonsense_Mutation_p.S16*|CACNB3_ENST00000547392.1_Nonsense_Mutation_p.S17*|CACNB3_ENST00000550168.1_3'UTR	NM_000725.3	NP_000716.2	P54284	CACB3_HUMAN	calcium channel, voltage-dependent, beta 3 subunit	17					axon guidance|membrane depolarization|synaptic transmission	cytosol|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			autonomic_ganglia(1)|breast(1)|large_intestine(5)|lung(4)|prostate(1)	12					Verapamil(DB00661)	ACCCAGGGTTCAGCCGACTCC	0.622000													14	98					0	0	1	0	0
NDC1	55706	broad.mit.edu	37	1	54266442	54266442	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:54266442G>C	ENST00000371429.3	-	11	1744	c.1146C>G	c.(1144-1146)ctC>ctG	p.L382L	NDC1_ENST00000234725.8_Silent_p.L267L|NDC1_ENST00000540001.1_Silent_p.L382L|NDC1_ENST00000537333.1_Silent_p.L47L	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		CTTCTTGATAGAGAATCAGTT	0.438000													31	64					0	0	1	0	0
C21orf58	54058	broad.mit.edu	37	21	47735387	47735387	+	Splice_Site	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr21:47735387C>T	ENST00000291691.7	-	4	1581		c.e4+1		C21orf58_ENST00000397685.4_Splice_Site|C21orf58_ENST00000397680.1_Splice_Site|C21orf58_ENST00000397679.1_Splice_Site|C21orf58_ENST00000397683.1_Splice_Site|C21orf58_ENST00000397682.3_Splice_Site	NM_058180.3	NP_478060.2	P58505	CU058_HUMAN	chromosome 21 open reading frame 58											breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(1)|pancreas(1)	9	Breast(49;0.112)			Colorectal(79;0.239)		GCAGGGCCTACCCGGAGTCTC	0.582000													12	58					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33973196	33973196	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:33973196G>C	ENST00000379238.1	-	7	677	c.560C>G	c.(559-561)tCa>tGa	p.S187*	UBAP2_ENST00000418786.2_Intron|UBAP2_ENST00000379239.4_Intron|UBAP2_ENST00000360802.1_Nonsense_Mutation_p.S187*|UBAP2_ENST00000539807.1_Intron|UBAP2_ENST00000449054.1_Nonsense_Mutation_p.S187*			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	187										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GCCTTGGGTTGAGAACCTTCC	0.358000													45	161					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64394072	64394072	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:64394072C>G	ENST00000262043.3	+	4	789	c.449C>G	c.(448-450)tCa>tGa	p.S150*	PHF3_ENST00000509330.1_Nonsense_Mutation_p.S150*|PHF3_ENST00000393387.1_Nonsense_Mutation_p.S150*			Q92576	PHF3_HUMAN	PHD finger protein 3	150					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			GCCAAGCGTTCAAATGCAGCA	0.368000													75	189					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9258684	9258684	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:9258684G>C	ENST00000383440.2	+	8	5607	c.5350G>C	c.(5350-5352)Gag>Cag	p.E1784Q	ANKRD12_ENST00000400020.3_Missense_Mutation_p.E1784Q|ANKRD12_ENST00000262126.3_Missense_Mutation_p.E1807Q	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	1807						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						ACAAGCAAAAGAGAAAACTCA	0.413000													16	64					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27875058	27875058	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:27875058G>C	ENST00000374011.2	-	6	4537	c.3569C>G	c.(3568-3570)tCa>tGa	p.S1190*	AHDC1_ENST00000482400.2_Intron|AHDC1_ENST00000247087.5_Nonsense_Mutation_p.S1190*	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	1190							DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		CTCACTACTTGAGGCCTCGCT	0.602000													11	88					0	0	1	0	0
TRIP4	9325	broad.mit.edu	37	15	64716342	64716342	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:64716342C>G	ENST00000261884.3	+	10	1531	c.1471C>G	c.(1471-1473)Ctt>Gtt	p.L491V		NM_016213.4	NP_057297.2	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	491					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21						ATATCGTCTTCTTCGTGGGAA	0.453000													37	41					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133760560	133760560	+	Silent	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:133760560G>T	ENST00000318560.5	+	11	3264	c.2883G>T	c.(2881-2883)ccG>ccT	p.P961P		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	961	DNA-binding (By similarity).|F-actin-binding.|Pro-rich.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CCGTGCTCCCGGCCACTCCAA	0.657000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								40	140					3.86236e-30	4.41499e-30	1	1	0
TMTC3	160418	broad.mit.edu	37	12	88589091	88589091	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:88589091G>A	ENST00000266712.6	+	14	2630	c.2410G>A	c.(2410-2412)Gaa>Aaa	p.E804K		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	805						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						AGCACCACATGAAGAATATAT	0.348000													33	118					0	0	1	0	0
SLMO2	51012	broad.mit.edu	37	20	57613527	57613527	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:57613527C>T	ENST00000355937.4	-	2	373	c.195G>A	c.(193-195)gtG>gtA	p.V65V	SLMO2_ENST00000371033.5_Silent_p.V65V	NM_016045.2	NP_057129.2	Q9Y3B1	SLMO2_HUMAN	slowmo homolog 2 (Drosophila)	65	PRELI/MSF1.									endometrium(1)|lung(2)|skin(2)	5	all_lung(29;0.00711)		Colorectal(105;0.109)			TTACAGACTTCACAATGGAAG	0.453000													31	123					0	0	1	0	0
AC112229.4	0	broad.mit.edu	37	2	111144370	111144370	+	RNA	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:111144370T>C	ENST00000606848.1	-	0	1370																											GGCAGCACCATAGTGGCGGCC	0.622000													3	9					0	0	1	0	0
TAS2R5	54429	broad.mit.edu	37	7	141490167	141490167	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:141490167G>A	ENST00000247883.4	+	1	151	c.6G>A	c.(4-6)ctG>ctA	p.L2L		NM_018980.2	NP_061853.1	Q9NYW4	TA2R5_HUMAN	taste receptor, type 2, member 5	2					chemosensory behavior|sensory perception of taste		taste receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9	Melanoma(164;0.0171)					CAGCCATGCTGAGCGCTGGCC	0.512000													37	75					0	0	1	0	0
PDE3B	5140	broad.mit.edu	37	11	14808039	14808039	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:14808039G>T	ENST00000282096.4	+	3	1439	c.1086G>T	c.(1084-1086)atG>atT	p.M362I	PDE3B_ENST00000455098.2_Missense_Mutation_p.M362I	NM_000922.3	NP_000913.2	Q13370	PDE3B_HUMAN	phosphodiesterase 3B, cGMP-inhibited	362					cAMP catabolic process|insulin receptor signaling pathway|negative regulation of lipid catabolic process|platelet activation	cytosol|endoplasmic reticulum|Golgi apparatus|guanyl-nucleotide exchange factor complex|integral to membrane|microsome	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding|protein kinase B binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CTCGCAATATGGTGTCAGATC	0.413000													38	122					1.47244e-24	1.67261e-24	1	1	0
AGBL1	123624	broad.mit.edu	37	15	87089268	87089268	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:87089268G>A	ENST00000441037.2	+	19	2678	c.2583G>A	c.(2581-2583)aaG>aaA	p.K861K	AGBL1_ENST00000389298.3_Silent_p.K592K|AGBL1_ENST00000421325.2_Silent_p.K861K	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	861					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						CCCAAAAGAAGAATGTGTTCC	0.438000													17	24					0	0	1	0	0
CRIM1	51232	broad.mit.edu	37	2	36744610	36744610	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:36744610G>A	ENST00000280527.2	+	12	2498	c.2131G>A	c.(2131-2133)Gag>Aag	p.E711K		NM_016441.2	NP_057525.1	Q9NZV1	CRIM1_HUMAN	cysteine rich transmembrane BMP regulator 1 (chordin-like)	711	VWFC 4.				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity	p.E711Q(1)		autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(15)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	45		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				GGTGCTGTGTGAGACAGAGGT	0.582000													27	112					0	0	1	0	0
BFSP2	8419	broad.mit.edu	37	3	133118930	133118930	+	Translation_Start_Site	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:133118930G>A	ENST00000302334.2	+	1	92	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_003571.2	NP_003562.1	Q13515	BFSP2_HUMAN	beaded filament structural protein 2, phakinin	1	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|urinary_tract(1)	13						AAGGGGTGATGAGTGAGAGGC	0.622000													35	162					0	0	1	0	0
TTC17	55761	broad.mit.edu	37	11	43427106	43427106	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:43427106G>A	ENST00000039989.4	+	12	1536	c.1522G>A	c.(1522-1524)Gaa>Aaa	p.E508K	TTC17_ENST00000526774.1_3'UTR|TTC17_ENST00000299240.6_Missense_Mutation_p.E508K	NM_018259.5	NP_060729.2	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	508							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(27)|ovary(5)|prostate(3)|skin(3)	53						AGATTGTACAGAAAGCTACCC	0.393000													73	329					0	0	1	0	0
B4GALNT1	2583	broad.mit.edu	37	12	58021515	58021515	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:58021515C>A	ENST00000341156.4	-	10	1854	c.1270G>T	c.(1270-1272)Gtc>Ttc	p.V424F	B4GALNT1_ENST00000418555.2_Missense_Mutation_p.V369F	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	424					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GGGAAGCCGACGAGCTCGTGG	0.687000													4	29					0.150653	0.151487	1	1	0
FAM120C	54954	broad.mit.edu	37	X	54209131	54209131	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:54209131G>C	ENST00000375180.2	-	1	557	c.501C>G	c.(499-501)ctC>ctG	p.L167L	FAM120C_ENST00000477084.1_Silent_p.L167L|FAM120C_ENST00000328235.4_Silent_p.L167L|FAM120C_ENST00000497680.1_5'UTR	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	167										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						ACATGACCACGAGCTCCAGGC	0.682000													9	12					0	0	1	0	0
ZNF492	57615	broad.mit.edu	37	19	22846914	22846914	+	Missense_Mutation	SNP	A	A	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:22846914A>T	ENST00000456783.2	+	4	687	c.443A>T	c.(442-444)aAg>aTg	p.K148M		NM_020855.2	NP_065906.1	Q9P255	ZN492_HUMAN	zinc finger protein 492	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		all_cancers(12;0.0266)|all_lung(12;0.00187)|Lung NSC(12;0.0019)|all_epithelial(12;0.00203)|Hepatocellular(1079;0.244)				GAATGTGAAAAGTCATTTTGC	0.318000													3	34					0	0	1	0	0
FARP2	9855	broad.mit.edu	37	2	242380735	242380735	+	Missense_Mutation	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:242380735A>G	ENST00000264042.3	+	13	1345	c.1175A>G	c.(1174-1176)gAg>gGg	p.E392G	FARP2_ENST00000545004.1_Missense_Mutation_p.E392G|FARP2_ENST00000373287.4_Missense_Mutation_p.E392G	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	392					axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		TCATTCCCCGAGGGATTGAGG	0.478000													42	167					0	0	1	0	0
RCN2	5955	broad.mit.edu	37	15	77227977	77227977	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:77227977G>A	ENST00000394885.3	+	3	584	c.361G>A	c.(361-363)Gaa>Aaa	p.E121K	RCN2_ENST00000320963.5_Missense_Mutation_p.E121K|RCN2_ENST00000394883.3_Intron	NM_002902.2	NP_002893.1	Q14257	RCN2_HUMAN	reticulocalbin 2, EF-hand calcium binding domain	121	EF-hand 2.					endoplasmic reticulum lumen	calcium ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(1)	7						GACTTGGGATGAATATAACAT	0.373000													32	64					0	0	1	0	0
KLF10	7071	broad.mit.edu	37	8	103663385	103663385	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:103663385G>A	ENST00000395884.3	-	3	2044	c.1142C>T	c.(1141-1143)aCg>aTg	p.T381M	KLF10_ENST00000285407.6_Missense_Mutation_p.T392M	NM_001032282.2	NP_001027453.1	Q13118	KLF10_HUMAN	Kruppel-like factor 10	392					cell proliferation|cell-cell signaling|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|skeletal system development|transforming growth factor beta receptor signaling pathway	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(8)|prostate(3)	18	all_epithelial(15;5.63e-07)|Lung NSC(17;8.18e-05)|all_lung(17;0.000169)		OV - Ovarian serous cystadenocarcinoma(57;0.000112)|STAD - Stomach adenocarcinoma(118;0.0826)			ACCTGTGTGCGTCCTCGTGTG	0.428000													16	255					0	0	1	0	0
CLIP3	25999	broad.mit.edu	37	19	36509865	36509865	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:36509865G>A	ENST00000360535.4	-	9	1345	c.1118C>T	c.(1117-1119)tCc>tTc	p.S373F	AC002116.7_ENST00000586962.1_RNA|CLIP3_ENST00000593074.1_Missense_Mutation_p.S373F	NM_015526.2	NP_056341.1	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	373					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			cervix(1)|endometrium(6)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	23	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CCGGGGTGTGGAGGTGACAGA	0.622000													21	96					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53348749	53348749	+	Missense_Mutation	SNP	A	A	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:53348749A>C	ENST00000566029.1	+	36	7538	c.7329A>C	c.(7327-7329)ttA>ttC	p.L2443F	CHD9_ENST00000398510.3_Missense_Mutation_p.L2459F|CHD9_ENST00000447540.1_Missense_Mutation_p.L2444F|CHD9_ENST00000564845.1_Missense_Mutation_p.L2443F			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2459	Binds A/T-rich DNA.				cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				CTTTAGGCTTAACCTCCTCAC	0.323000													29	72					0	0	1	0	0
MACROD2	140733	broad.mit.edu	37	20	15913923	15913923	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:15913923G>A	ENST00000217246.4	+	11	1173	c.778G>A	c.(778-780)Gag>Aag	p.E260K	MACROD2_ENST00000402914.1_Missense_Mutation_p.E25K|MACROD2_ENST00000378058.3_Missense_Mutation_p.E25K|MACROD2_ENST00000310348.4_Missense_Mutation_p.E260K	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	260	Glu-rich.									breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				CTTGAAAGATGAGAACGGTCC	0.398000													15	66					0	0	1	0	0
ADAT3	113179	broad.mit.edu	37	19	1912274	1912274	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:1912274G>A	ENST00000329478.2	+	2	448	c.228G>A	c.(226-228)ctG>ctA	p.L76L	SCAMP4_ENST00000414057.2_Intron|SCAMP4_ENST00000409472.1_Intron|SCAMP4_ENST00000316097.8_Intron|ADAT3_ENST00000602400.1_Silent_p.L60L			Q96EY9	ADAT3_HUMAN	adenosine deaminase, tRNA-specific 3	60					tRNA processing		hydrolase activity|zinc ion binding			breast(1)|kidney(3)|pancreas(1)|skin(2)	7		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACGCCTCCTGAAGGAGGTGT	0.721000													3	7					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67576085	67576085	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:67576085G>A	ENST00000540839.3	+	14	1676	c.1456G>A	c.(1456-1458)Gag>Aag	p.E486K	FAM65A_ENST00000042381.4_Missense_Mutation_p.E466K|FAM65A_ENST00000379312.3_Missense_Mutation_p.E470K|CTD-2012K14.3_ENST00000563083.1_RNA|FAM65A_ENST00000428437.2_Missense_Mutation_p.E480K|FAM65A_ENST00000422602.2_Missense_Mutation_p.E486K			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	470	Pro-rich.					cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GGCTTCAGTGGAGGCCGTTGG	0.622000													30	132					0	0	1	0	0
CER1	9350	broad.mit.edu	37	9	14722167	14722167	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:14722167G>T	ENST00000380911.3	-	1	548	c.504C>A	c.(502-504)agC>agA	p.S168R		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	168	CTCK.				BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		CACATACCTGGCTGAAGGGCA	0.537000													19	57					7.87624e-14	8.58475e-14	1	1	0
FRYL	285527	broad.mit.edu	37	4	48559525	48559525	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:48559525C>A	ENST00000358350.4	-	34	4674	c.4070G>T	c.(4069-4071)gGa>gTa	p.G1357V	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507873.2_5'UTR|FRYL_ENST00000503238.1_Missense_Mutation_p.G1357V|FRYL_ENST00000537810.1_Missense_Mutation_p.G1357V|FRYL_ENST00000507711.1_Missense_Mutation_p.G1357V	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	1357					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						TTGTGGAGATCCCCATCCTTC	0.423000													38	107					4.32679e-17	4.80241e-17	1	1	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10863040	10863040	+	RNA	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr21:10863040G>T	ENST00000559480.1	+	0	336																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						ACACGGCCATGTATTACTGTG	0.507000													78	713					2.93434e-44	3.39691e-44	1	1	0
ELAVL1	1994	broad.mit.edu	37	19	8056709	8056709	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:8056709C>A	ENST00000351593.5	-	2	158	c.72G>T	c.(70-72)ttG>ttT	p.L24F	ELAVL1_ENST00000407627.2_5'UTR|ELAVL1_ENST00000596459.1_5'UTR|ELAVL1_ENST00000593807.1_5'UTR			Q15717	ELAV1_HUMAN	ELAV like RNA binding protein 1	0	RRM 1.				3'-UTR-mediated mRNA stabilization|multicellular organismal development	cytoplasm|nucleoplasm	identical protein binding|mRNA binding|nucleotide binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TTGTATTTTTCAAAAATCTGC	0.383000													7	51					0.000157383	0.000160925	1	1	0
USP20	10868	broad.mit.edu	37	9	132630324	132630324	+	Missense_Mutation	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:132630324A>G	ENST00000315480.4	+	11	889	c.731A>G	c.(730-732)cAc>cGc	p.H244R	USP20_ENST00000372429.3_Missense_Mutation_p.H244R|USP20_ENST00000358355.1_Missense_Mutation_p.H244R			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	244					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				GACCAGCTGCACGAGGAGCTC	0.637000													36	147					0	0	1	0	0
MAP7	9053	broad.mit.edu	37	6	136693704	136693704	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:136693704G>A	ENST00000354570.3	-	8	1221	c.811C>T	c.(811-813)Cga>Tga	p.R271*	MAP7_ENST00000438100.2_Nonsense_Mutation_p.R256*|MAP7_ENST00000454590.1_Nonsense_Mutation_p.R293*|MAP7_ENST00000432797.2_Nonsense_Mutation_p.R125*|MAP7_ENST00000544465.1_Nonsense_Mutation_p.R256*	NM_001198616.1|NM_001198617.1|NM_001198619.1|NM_003980.4	NP_001185545.1|NP_001185546.1|NP_001185548.1|NP_003971.1	Q14244	MAP7_HUMAN	microtubule-associated protein 7	271					establishment or maintenance of cell polarity|microtubule cytoskeleton organization|protein localization in plasma membrane|response to osmotic stress	basolateral plasma membrane|microtubule|microtubule associated complex|nucleus|perinuclear region of cytoplasm	receptor binding|structural molecule activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(11)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00199)|OV - Ovarian serous cystadenocarcinoma(155;0.00643)		AGTTTTGGTCGATCCATCGAA	0.517000													13	81					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628259	71628259	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:71628259C>T	ENST00000377276.2	-	1	780	c.750G>A	c.(748-750)aaG>aaA	p.K250K		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	250	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CAGAGACGATCTTCTCGTAGA	0.607000													11	130					0	0	1	0	0
PCDHA6	56142	broad.mit.edu	37	5	140209291	140209291	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:140209291G>T	ENST00000529310.1	+	1	1729	c.1615G>T	c.(1615-1617)Gac>Tac	p.D539Y	PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529859.1_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCGCGCGCGACGCGGGCGT	0.687000													74	227					3.79363e-24	4.29591e-24	1	1	0
ELOVL4	6785	broad.mit.edu	37	6	80656897	80656897	+	Splice_Site	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:80656897C>G	ENST00000369816.4	-	1	400	c.100_splice	c.e1+1	p.D34_splice		NM_022726.3	NP_073563.1	Q9GZR5	ELOV4_HUMAN	ELOVL fatty acid elongase 4	34					fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	G-protein coupled photoreceptor activity|protein binding|transferase activity, transferring acyl groups other than amino-acyl groups			central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;1.83e-05)|Acute lymphoblastic leukemia(125;1.1e-05)|all_hematologic(105;0.00117)|all_epithelial(107;0.011)		BRCA - Breast invasive adenocarcinoma(397;0.0168)	Alpha-Linolenic Acid(DB00132)	GCGGCTTTACCTGCGATGGAC	0.692000													6	25					0	0	1	0	0
FZD2	2535	broad.mit.edu	37	17	42636336	42636336	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:42636336G>A	ENST00000315323.3	+	1	1412	c.1280G>A	c.(1279-1281)gGc>gAc	p.G427D		NM_001466.3	NP_001457.1	Q14332	FZD2_HUMAN	frizzled family receptor 2	427					axonogenesis|brain development|canonical Wnt receptor signaling pathway|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|positive regulation of cGMP metabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding	p.G427D(1)		central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(8)	33		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CTGTTCATCGGCACGTCCTTC	0.642000													47	144					0	0	1	0	0
ZNF202	7753	broad.mit.edu	37	11	123601559	123601559	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:123601559C>A	ENST00000336139.4	-	3	400	c.38G>T	c.(37-39)tGg>tTg	p.W13L	ZNF202_ENST00000530393.1_Missense_Mutation_p.W13L|ZNF202_ENST00000529691.1_Missense_Mutation_p.W13L			O95125	ZN202_HUMAN	zinc finger protein 202	13					lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.03)		CTCTTCTTCCCAAAGATCCTG	0.537000													41	70					1.8453e-21	2.07989e-21	1	1	0
PAX1	5075	broad.mit.edu	37	20	21687652	21687652	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:21687652C>T	ENST00000398485.2	+	2	917	c.863C>T	c.(862-864)tCg>tTg	p.S288L	PAX1_ENST00000444366.2_Missense_Mutation_p.S264L|PAX1_ENST00000460221.1_3'UTR	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	288					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						TCATGGCCCTCGGCACACTCG	0.667000													18	90					0	0	1	0	0
PHF14	9678	broad.mit.edu	37	7	11076235	11076235	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:11076235C>T	ENST00000403050.3	+	9	2245	c.1793C>T	c.(1792-1794)tCa>tTa	p.S598L	PHF14_ENST00000445996.2_Missense_Mutation_p.S313L	NM_014660.3	NP_055475.2	O94880	PHF14_HUMAN	PHD finger protein 14	598							zinc ion binding			NS(2)|breast(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	35				UCEC - Uterine corpus endometrioid carcinoma (126;0.205)		GTGGACAATTCAGATACTAGT	0.423000													13	50					0	0	1	0	0
PSMD2	5708	broad.mit.edu	37	3	184018147	184018147	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:184018147C>T	ENST00000310118.4	+	3	830	c.272C>T	c.(271-273)tCa>tTa	p.S91L	PSMD2_ENST00000459910.1_3'UTR|EIF2B5_ENST00000444495.1_Intron	NM_002808.3	NP_002799.3	Q13200	PSMD2_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	91					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|liver(1)|lung(12)|prostate(3)|upper_aerodigestive_tract(2)	27	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	TCCATGACTTCAGTGCCCAAG	0.478000													30	118					0	0	1	0	0
IRF2BPL	64207	broad.mit.edu	37	14	77494044	77494044	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:77494044G>C	ENST00000238647.3	-	1	990	c.92C>G	c.(91-93)tCg>tGg	p.S31W		NM_024496.3	NP_078772.1	Q9H1B7	I2BPL_HUMAN	interferon regulatory factor 2 binding protein-like	31						nucleus				endometrium(2)|kidney(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	11						TACGGGTTCCGAGAAGTCCCA	0.642000													22	71					0	0	1	0	0
GCN1L1	10985	broad.mit.edu	37	12	120612967	120612967	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:120612967G>C	ENST00000300648.6	-	12	1103	c.1091C>G	c.(1090-1092)tCa>tGa	p.S364*		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	364					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCCTATACCTGAGAGGACGCT	0.413000													17	98					0	0	1	0	0
C9orf172	389813	broad.mit.edu	37	9	139741083	139741083	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:139741083C>G	ENST00000436881.1	+	1	2217	c.2217C>G	c.(2215-2217)atC>atG	p.I739M		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	739										endometrium(2)|large_intestine(1)|lung(6)	9						TCTCGCGCATCGCGCGTGTCG	0.706000													7	33					0	0	1	0	0
DCST2	127579	broad.mit.edu	37	1	155005659	155005659	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:155005659G>T	ENST00000368424.3	-	2	408	c.350C>A	c.(349-351)aCc>aAc	p.T117N	DCST2_ENST00000295536.5_Missense_Mutation_p.T117N	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	117						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCTGGCCCGGGTGAAGTTGCG	0.617000													15	35					0.00244969	0.00248733	1	1	0
NRXN3	9369	broad.mit.edu	37	14	79432423	79432423	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:79432423C>A	ENST00000554719.1	+	9	1823	c.1332C>A	c.(1330-1332)atC>atA	p.I444I	NRXN3_ENST00000335750.5_Silent_p.I444I	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	0					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		AAACGGGAATCATGACTGAGA	0.433000													19	75					4.63292e-17	5.13435e-17	1	1	0
SNX13	23161	broad.mit.edu	37	7	17915323	17915323	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:17915323C>G	ENST00000409389.1	-	6	703	c.531G>C	c.(529-531)caG>caC	p.Q177H	SNX13_ENST00000428135.3_Missense_Mutation_p.Q177H			Q9Y5W8	SNX13_HUMAN	sorting nexin 13	177	PXA.				cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					CTGTTATTTTCTGTTGAGCCT	0.308000													9	21					0	0	1	0	0
DHRS7	51635	broad.mit.edu	37	14	60611732	60611732	+	Splice_Site	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:60611732C>T	ENST00000216500.5	-	8	1428		c.e8-1		DHRS7_ENST00000536410.2_Splice_Site|PCNXL4_ENST00000406949.1_Intron|DHRS7_ENST00000557185.1_Splice_Site			Q9Y394	DHRS7_HUMAN	dehydrogenase/reductase (SDR family) member 7								binding|oxidoreductase activity			endometrium(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	5				OV - Ovarian serous cystadenocarcinoma(108;0.121)		AGTCTGCATCCTGTAAAAGAG	0.358000													21	86					0	0	1	0	0
ZKSCAN2	342357	broad.mit.edu	37	16	25268335	25268335	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:25268335C>G	ENST00000328086.7	-	1	917	c.114G>C	c.(112-114)tcG>tcC	p.S38S		NM_001012981.4	NP_001012999.3	Q63HK3	ZKSC2_HUMAN	zinc finger with KRAB and SCAN domains 2	38					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)	36				GBM - Glioblastoma multiforme(48;0.0378)		CAGAGCTATCCGATCCTTCCA	0.517000											OREG0023690	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	113					0	0	1	0	0
KRT74	121391	broad.mit.edu	37	12	52966242	52966242	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:52966242C>T	ENST00000549343.1	-	2	719	c.681G>A	c.(679-681)aaG>aaA	p.K227K	KRT74_ENST00000305620.2_Silent_p.K227K			Q7RTS7	K2C74_HUMAN	keratin 74	227	Coil 1B.|Rod.					keratin filament	structural molecule activity			kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	28				BRCA - Breast invasive adenocarcinoma(357;0.191)		CTCACCTCTTCTTATAGTCCT	0.562000													11	157					0	0	1	0	0
ACTB	60	broad.mit.edu	37	7	5569282	5569282	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:5569282C>T	ENST00000331789.5	-	2	198	c.7G>A	c.(7-9)Gat>Aat	p.D3N		NM_001101.3	NP_001092.1	P60709	ACTB_HUMAN	actin, beta	3					'de novo' posttranslational protein folding|adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol|MLL5-L complex|NuA4 histone acetyltransferase complex|ribonucleoprotein complex	ATP binding|kinesin binding|nitric-oxide synthase binding|structural constituent of cytoskeleton			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(2)|prostate(2)	8		Ovarian(82;0.0606)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)|OV - Ovarian serous cystadenocarcinoma(56;4.24e-37)		GCGATATCATCATCCATGGTG	0.716000													19	58					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20523043	20523043	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:20523043G>A	ENST00000359062.3	+	1	865	c.825G>A	c.(823-825)ctG>ctA	p.L275L	RP11-284H19.1_ENST00000535755.1_RNA	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	275					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding	p.L275L(1)		NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GGTCCCAGCTGATTGCTGGGA	0.627000													9	112					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11204541	11204541	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:11204541G>A	ENST00000337414.4	-	5	1960	c.1088C>T	c.(1087-1089)tCa>tTa	p.S363L	ARHGAP6_ENST00000380736.1_Missense_Mutation_p.S160L|ARHGAP6_ENST00000303025.6_Missense_Mutation_p.S160L|ARHGAP6_ENST00000413512.3_Missense_Mutation_p.S172L|ARHGAP6_ENST00000380718.1_Missense_Mutation_p.S363L|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.S395L|ARHGAP6_ENST00000534860.1_Missense_Mutation_p.S188L	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	363					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						AGAATCCACTGACATGGCACC	0.448000													50	49					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502213	140502213	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:140502213C>T	ENST00000194152.1	+	1	633	c.633C>T	c.(631-633)ctC>ctT	p.L211L		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		211	Cadherin 2.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCTTAACCCTCGTGGCGCTGG	0.512000													25	71					0	0	1	0	0
IPO4	79711	broad.mit.edu	37	14	24653082	24653082	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:24653082G>C	ENST00000354464.6	-	19	2068	c.1892C>G	c.(1891-1893)tCc>tGc	p.S631C	RP11-468E2.2_ENST00000561419.1_3'UTR	NM_024658.3	NP_078934.3	Q8TEX9	IPO4_HUMAN	importin 4	631					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(10)|ovary(1)|stomach(2)|urinary_tract(1)	33				GBM - Glioblastoma multiforme(265;0.0087)		CAGAAGGAAGGAGCTGCTCCC	0.572000													39	112					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10542213	10542213	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:10542213G>C	ENST00000583535.1	-	26	3403	c.3316C>G	c.(3316-3318)Cag>Gag	p.Q1106E	MYH3_ENST00000226209.7_Missense_Mutation_p.Q1106E	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1106					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						ATTTTCTTCTGAAACTGGAGG	0.433000													17	68					0	0	1	0	0
ZNF507	22847	broad.mit.edu	37	19	32873415	32873415	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:32873415G>C	ENST00000311921.3	+	5	2595	c.2403G>C	c.(2401-2403)ttG>ttC	p.L801F	ZNF507_ENST00000355898.5_Missense_Mutation_p.L801F|ZNF507_ENST00000544431.1_Missense_Mutation_p.L805F	NM_001136156.1|NM_014910.4	NP_001129628.1|NP_055725.2	Q8TCN5	ZN507_HUMAN	zinc finger protein 507	801					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	31	Esophageal squamous(110;0.162)					CTCCTTCTTTGAAGTCTCATA	0.423000													64	196					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33237497	33237497	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:33237497C>T	ENST00000401073.2	+	6	2787	c.2717C>T	c.(2716-2718)tCg>tTg	p.S906L	KIAA1522_ENST00000373480.1_Missense_Mutation_p.S847L|KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373481.3_Missense_Mutation_p.S858L	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	847	Pro-rich.							p.S906L(2)		breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				CTGGGGCCATCGGCCCCCCAG	0.721000													7	26					0	0	1	0	0
BAD	572	broad.mit.edu	37	11	64037768	64037768	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:64037768C>T	ENST00000544785.1	-	2	229	c.229G>A	c.(229-231)Gat>Aat	p.D77N	BAD_ENST00000394532.3_Silent_p.Q140Q|BAD_ENST00000309032.3_Silent_p.Q140Q|BAD_ENST00000394531.3_3'UTR			Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	76					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4						TTTGCCGCATCTGCGTTGCTG	0.612000													30	66					0	0	1	0	0
CHRNA2	1135	broad.mit.edu	37	8	27321177	27321177	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:27321177G>A	ENST00000407991.1	-	6	1391	c.783C>T	c.(781-783)atC>atT	p.I261I	CHRNA2_ENST00000240132.2_Silent_p.I246I|CHRNA2_ENST00000520933.2_Silent_p.I261I	NM_000742.3	NP_000733.2	Q15822	ACHA2_HUMAN	cholinergic receptor, nicotinic, alpha 2 (neuronal)	261						cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0208)|Epithelial(17;2.77e-10)|Colorectal(74;0.136)	Atracurium(DB00732)|Biperiden(DB00810)|Carbachol(DB00411)|Cisatracurium Besylate(DB00565)|Decamethonium(DB01245)|Dextromethorphan(DB00514)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Gallamine Triethiodide(DB00483)|Levallorphan(DB00504)|Mecamylamine(DB00657)|Metocurine Iodide(DB00416)|Metocurine(DB01336)|Mivacurium(DB01226)|Nicotine(DB00184)|Pancuronium(DB01337)|Pipecuronium(DB01338)|Rocuronium(DB00728)|Tubocurarine(DB01199)	GCAGCCGCCGGATGACGAAGG	0.622000													13	84					0	0	1	0	0
TPST1	8460	broad.mit.edu	37	7	65705471	65705471	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:65705471C>G	ENST00000304842.5	+	2	484	c.59C>G	c.(58-60)aCt>aGt	p.T20S	TPST1_ENST00000480281.1_Intron	NM_003596.3	NP_003587.1	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	20					inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity			NS(1)|biliary_tract(1)|breast(1)|kidney(3)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						AGTTCTGTGACTGTGTTTTAC	0.443000													10	37					0	0	1	0	0
IZUMO1	284359	broad.mit.edu	37	19	49248543	49248543	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:49248543C>T	ENST00000332955.2	-	3	785	c.238G>A	c.(238-240)Gag>Aag	p.E80K		NM_182575.2	NP_872381.2	Q8IYV9	IZUM1_HUMAN	izumo sperm-egg fusion 1	80					fusion of sperm to egg plasma membrane	integral to membrane				endometrium(4)|kidney(3)|large_intestine(4)|lung(2)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	17		all_lung(116;0.000156)|Lung NSC(112;0.000251)|all_epithelial(76;0.000761)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000134)|all cancers(93;0.000348)|Epithelial(262;0.019)|GBM - Glioblastoma multiforme(486;0.022)		AGTGTGGCCTCATCTGTCAGA	0.493000													24	72					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124819806	124819806	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:124819806C>T	ENST00000356219.3	-	41	6462	c.6307G>A	c.(6307-6309)Gag>Aag	p.E2103K	NCOR2_ENST00000429285.2_Missense_Mutation_p.E2086K|NCOR2_ENST00000405201.1_Missense_Mutation_p.E2096K|NCOR2_ENST00000404121.2_Missense_Mutation_p.E1657K|NCOR2_ENST00000404621.1_Missense_Mutation_p.E2086K|NCOR2_ENST00000397355.1_Missense_Mutation_p.E2087K	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	2107					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		TGGGCGGCCTCCCCGCCAAGC	0.711000													8	22					0	0	1	0	0
LYZL2	119180	broad.mit.edu	37	10	30918603	30918603	+	Missense_Mutation	SNP	G	G	A	rs138080049		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:30918603G>A	ENST00000375318.2	-	1	88	c.32C>T	c.(31-33)cCg>cTg	p.P11L		NM_183058.2	NP_898881.2	Q7Z4W2	LYZL2_HUMAN	lysozyme-like 2	0					cell wall macromolecule catabolic process	extracellular region	lysozyme activity			NS(2)|central_nervous_system(1)|large_intestine(1)|lung(14)|prostate(1)	19		Prostate(175;0.151)				CCACTTAGTCGGTGACAGGCA	0.502000													9	112					0	0	1	0	0
USP13	8975	broad.mit.edu	37	3	179472617	179472617	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:179472617C>A	ENST00000263966.3	+	15	2367	c.1896C>A	c.(1894-1896)ccC>ccA	p.P632P	USP13_ENST00000496897.1_Silent_p.P567P|USP13_ENST00000482333.1_3'UTR	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	632					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			TCAGCCCCCCCATAGTCATTC	0.498000													48	162					1.35964e-18	1.51837e-18	1	1	0
PCSK2	5126	broad.mit.edu	37	20	17341202	17341202	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:17341202C>A	ENST00000262545.2	+	4	737	c.422C>A	c.(421-423)aCt>aAt	p.T141N	PCSK2_ENST00000377899.1_Missense_Mutation_p.T122N|PCSK2_ENST00000536609.1_Missense_Mutation_p.T106N	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	141	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCTGATGGCACTCCTGGCCTT	0.438000													5	29					0.0215528	0.0217321	1	1	0
EPS8L1	54869	broad.mit.edu	37	19	55592212	55592212	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:55592212G>A	ENST00000201647.6	+	7	558	c.502G>A	c.(502-504)Gcg>Acg	p.A168T	EPS8L1_ENST00000245618.5_Missense_Mutation_p.A41T|EPS8L1_ENST00000540810.1_Missense_Mutation_p.A104T|EPS8L1_ENST00000588359.1_Intron|EPS8L1_ENST00000586329.1_Missense_Mutation_p.A150T|EPS8L1_ENST00000592824.1_3'UTR	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	168						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		GCGCAGGGCGGCGGCGCTCAG	0.637000													7	29					0	0	1	0	0
EVPLL	645027	broad.mit.edu	37	17	18285004	18285004	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:18285004G>C	ENST00000399134.4	+	4	664	c.306G>C	c.(304-306)ggG>ggC	p.G102G	RP1-37N7.1_ENST00000579352.1_RNA	NM_001145127.1	NP_001138599.1	A8MZ36	EVPLL_HUMAN	envoplakin-like	102										NS(1)|endometrium(1)|large_intestine(1)|lung(2)	5						CCCGACGTGGGATCCAAGGTC	0.582000													14	37					0	0	1	0	0
ERP44	23071	broad.mit.edu	37	9	102744965	102744965	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:102744965C>G	ENST00000262455.6	-	12	1349	c.1150G>C	c.(1150-1152)Gag>Cag	p.E384Q		NM_015051.1	NP_055866.1	Q9BS26	ERP44_HUMAN	endoplasmic reticulum protein 44	384					cell redox homeostasis|glycoprotein metabolic process|protein folding|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|ER-Golgi intermediate compartment	protein binding|protein disulfide isomerase activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(2)	19						AAGGAGCTCTCAGGTGGACTG	0.348000													19	90					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22225380	22225380	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:22225380C>T	ENST00000324559.8	+	2	388	c.71C>T	c.(70-72)tCt>tTt	p.S24F		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	24						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						ATAGACTACTCTTTCCAAATG	0.279000													7	31					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038060	75038060	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:75038060C>T	ENST00000326665.5	-	14	3552	c.3334G>A	c.(3334-3336)Gag>Aag	p.E1112K	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1112	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GTCTCTTCCTCAGCTCTTACT	0.463000													33	113					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241492374	241492374	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:241492374C>T	ENST00000391987.1	-	4	536	c.170G>A	c.(169-171)cGa>cAa	p.R57Q	ANKMY1_ENST00000403283.1_Missense_Mutation_p.R225Q|ANKMY1_ENST00000401804.1_Missense_Mutation_p.R146Q|ANKMY1_ENST00000373318.2_Missense_Mutation_p.R146Q|ANKMY1_ENST00000373320.4_Missense_Mutation_p.R57Q|ANKMY1_ENST00000361678.4_Missense_Mutation_p.R146Q|ANKMY1_ENST00000536462.1_Missense_Mutation_p.R99Q|ANKMY1_ENST00000406958.1_Missense_Mutation_p.R146Q|ANKMY1_ENST00000272972.3_Missense_Mutation_p.R57Q|ANKMY1_ENST00000462004.1_5'UTR|ANKMY1_ENST00000405523.3_Missense_Mutation_p.R146Q|ANKMY1_ENST00000405002.1_Missense_Mutation_p.R57Q			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	57							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GTAGCCTTCTCGGTGGCTGAG	0.562000													39	112					0	0	1	0	0
ZNF737	100129842	broad.mit.edu	37	19	20728564	20728564	+	Missense_Mutation	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:20728564T>C	ENST00000427401.4	-	4	539	c.445A>G	c.(445-447)Aaa>Gaa	p.K149E		NM_001159293.1	NP_001152765.1	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	149					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(2)|kidney(1)|lung(7)|ovary(1)|stomach(1)|urinary_tract(1)	13						TTCACATATTTATCACACTGA	0.313000													19	33					0	0	1	0	0
KIF20A	10112	broad.mit.edu	37	5	137519250	137519250	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:137519250C>G	ENST00000394894.3	+	9	1345	c.1119C>G	c.(1117-1119)ctC>ctG	p.L373L	KIF20A_ENST00000508792.1_Silent_p.L355L	NM_005733.2	NP_005724.1	O95235	KI20A_HUMAN	kinesin family member 20A	373	Kinesin-motor.				cytokinesis|M phase of mitotic cell cycle|microtubule-based movement|protein transport|vesicle-mediated transport	Golgi apparatus|microtubule|nucleoplasm	ATP binding|microtubule motor activity|protein binding|transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|liver(2)|lung(9)|prostate(2)|upper_aerodigestive_tract(1)	27			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GCACCCACCTCAACCAGAACT	0.493000													32	99					0	0	1	0	0
SPOCK1	6695	broad.mit.edu	37	5	136448128	136448128	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:136448128G>C	ENST00000394945.1	-	5	639	c.470C>G	c.(469-471)tCc>tGc	p.S157C	SPOCK1_ENST00000282223.7_Missense_Mutation_p.S157C	NM_004598.3	NP_004589.1	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1	157	Kazal-like.				cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			ACCAACCTTGGATGTGTAGGA	0.488000													31	49					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228846466	228846466	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:228846466C>T	ENST00000392056.3	-	12	5116	c.5070G>A	c.(5068-5070)ctG>ctA	p.L1690L	SPHKAP_ENST00000344657.5_Silent_p.L1661L	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1690						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAAAGAGACTCAGTCTCCCAT	0.458000													22	93					0	0	1	0	0
TDRD1	56165	broad.mit.edu	37	10	115982430	115982430	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:115982430G>C	ENST00000251864.2	+	21	3128	c.2975G>C	c.(2974-2976)aGa>aCa	p.R992T	TDRD1_ENST00000369280.1_Missense_Mutation_p.R992T|TDRD1_ENST00000369282.1_Missense_Mutation_p.R992T|TDRD1_ENST00000422662.1_Missense_Mutation_p.R596T|TDRD1_ENST00000369281.2_Missense_Mutation_p.R878T	NM_198795.1	NP_942090.1	Q9BXT4	TDRD1_HUMAN	tudor domain containing 1	992	Tudor 4.				DNA methylation involved in gamete generation|gene silencing by RNA|germ cell development|meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	pi-body	nucleic acid binding|protein binding|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(5)	48		Colorectal(252;0.172)|Breast(234;0.188)		Epithelial(162;0.0343)|all cancers(201;0.0754)		TATAGACCAAGAATTGGAGAC	0.363000													32	113					0	0	1	0	0
INTS3	65123	broad.mit.edu	37	1	153745745	153745745	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:153745745G>A	ENST00000456435.1	+	29	3894	c.2708G>A	c.(2707-2709)tGa>tAa	p.*903*	INTS3_ENST00000512605.1_Silent_p.*903*|INTS3_ENST00000435409.2_Silent_p.*1043*|INTS3_ENST00000476843.1_3'UTR|INTS3_ENST00000318967.2_Silent_p.*1043*			Q68E01	INT3_HUMAN	integrator complex subunit 3	0					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GACAGTGACTGAGGCCCTGCA	0.557000													30	216					0	0	1	0	0
EBF1	1879	broad.mit.edu	37	5	158522672	158522672	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:158522672C>A	ENST00000313708.6	-	4	649	c.367G>T	c.(367-369)Gag>Tag	p.E123*	EBF1_ENST00000518836.1_5'UTR|EBF1_ENST00000517373.1_Nonsense_Mutation_p.E123*|EBF1_ENST00000380654.4_Nonsense_Mutation_p.E123*	NM_024007.3	NP_076870.1	Q9UH73	COE1_HUMAN	early B-cell factor 1	123					multicellular organismal development	nucleus	DNA binding|metal ion binding		HMGA2/EBF1(2)	breast(3)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42	Renal(175;0.00196)	Acute lymphoblastic leukemia(3;2.99e-06)|all_hematologic(3;0.000772)|Medulloblastoma(196;0.037)|all_neural(177;0.143)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAATCCTGCTCCGTCCTTATC	0.458000			T	HMGA2	lipoma								7	38					5.68852e-11	6.12675e-11	1	1	0
ARMC5	79798	broad.mit.edu	37	16	31475971	31475971	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:31475971G>T	ENST00000457010.2	+	4	2328	c.1627G>T	c.(1627-1629)Gtg>Ttg	p.V543L	ARMC5_ENST00000538189.1_Missense_Mutation_p.V575L|ARMC5_ENST00000408912.3_Missense_Mutation_p.V638L|ARMC5_ENST00000268314.4_Missense_Mutation_p.V543L|ARMC5_ENST00000412665.2_Missense_Mutation_p.V187L|ARMC5_ENST00000563544.1_Missense_Mutation_p.V543L	NM_024742.2	NP_079018.1	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5	543							binding			central_nervous_system(1)|endometrium(4)|large_intestine(3)|liver(2)|lung(12)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						TGGGGCACTTGTGACCGGCCC	0.706000													10	35					0.0135373	0.0136689	1	1	0
MCF2L2	23101	broad.mit.edu	37	3	182937685	182937685	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:182937685C>G	ENST00000328913.3	-	21	2626	c.2329G>C	c.(2329-2331)Gat>Cat	p.D777H	MCF2L2_ENST00000473233.1_Missense_Mutation_p.D777H	NM_015078.2	NP_055893.2	Q86YR7	MF2L2_HUMAN	MCF.2 cell line derived transforming sequence-like 2	777	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(25)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	72	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ATCTCCATATCTTCAGGAGAC	0.353000													20	104					0	0	1	0	0
APPL2	55198	broad.mit.edu	37	12	105593217	105593217	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:105593217G>C	ENST00000258530.3	-	10	1022	c.797C>G	c.(796-798)tCt>tGt	p.S266C	APPL2_ENST00000549573.1_5'UTR|APPL2_ENST00000539978.2_Missense_Mutation_p.S223C|APPL2_ENST00000551662.1_Missense_Mutation_p.S272C	NM_001251904.1|NM_018171.3	NP_001238833.1|NP_060641.2	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	266	Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						GGCCACATCAGAGTCTGGAGT	0.473000													5	94					0	0	1	0	0
HRCT1	646962	broad.mit.edu	37	9	35906559	35906559	+	Missense_Mutation	SNP	A	A	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:35906559A>C	ENST00000354323.2	+	1	371	c.275A>C	c.(274-276)cAc>cCc	p.H92P		NM_001039792.1	NP_001034881.1	Q6UXD1	HRCT1_HUMAN	histidine rich carboxyl terminus 1	92	His-rich.					integral to membrane		p.H92P(1)		NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|prostate(1)	4						caccaccaccacccccgccac	0.682000													10	22					0	0	1	0	0
OAS3	4940	broad.mit.edu	37	12	113379508	113379508	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:113379508C>T	ENST00000228928.7	+	2	490	c.311C>T	c.(310-312)tCg>tTg	p.S104L	RP1-71H24.1_ENST00000552784.1_RNA|OAS3_ENST00000548514.1_Missense_Mutation_p.S104L|OAS3_ENST00000546638.1_Intron|OAS3_ENST00000551007.1_Missense_Mutation_p.S104L	NM_006187.2	NP_006178.2	Q9Y6K5	OAS3_HUMAN	2'-5'-oligoadenylate synthetase 3, 100kDa	104	OAS domain 1.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	microsome	ATP binding|nucleotidyltransferase activity|RNA binding			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(6)|ovary(1)|skin(2)	27						ATGCGGGCATCGCTGGAATCC	0.587000													19	155					0	0	1	0	0
CRYGS	1427	broad.mit.edu	37	3	186257180	186257180	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:186257180G>C	ENST00000392499.2	-	3	567	c.228C>G	c.(226-228)ctC>ctG	p.L76L	CRYGS_ENST00000307944.5_Silent_p.L76L	NM_017541.2	NP_060011.1	P22914	CRBS_HUMAN	crystallin, gamma S	76	Beta/gamma crystallin 'Greek key' 2.						structural constituent of eye lens			endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	11	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.5e-22)	GBM - Glioblastoma multiforme(93;0.0906)		GGCGGTCGTTGAGGCCCATCC	0.542000													23	114					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233363037	233363037	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:233363037G>C	ENST00000258229.8	-	10	2673	c.2439C>G	c.(2437-2439)atC>atG	p.I813M	PCNXL2_ENST00000430153.1_Missense_Mutation_p.I112M	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	813						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CAGGGAAAATGATAAATTTGT	0.423000													19	102					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599190	29599190	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:29599190G>A	ENST00000431530.3	+	1	443	c.385G>A	c.(385-387)Gat>Aat	p.D129N		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	119						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GAGAGGCACAGATAGCCTGCA	0.507000													20	98					0	0	1	0	0
PPP1CC	5501	broad.mit.edu	37	12	111160362	111160362	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:111160362C>T	ENST00000335007.5	-	5	852	c.662G>A	c.(661-663)aGa>aAa	p.R221K	PPP1CC_ENST00000546933.1_Missense_Mutation_p.R230K|PPP1CC_ENST00000340766.5_Missense_Mutation_p.R221K|PPP1CC_ENST00000551676.1_Missense_Mutation_p.R221K|PPP1CC_ENST00000550991.1_Missense_Mutation_p.R221K	NM_002710.3	NP_002701.1	P36873	PP1G_HUMAN	protein phosphatase 1, catalytic subunit, gamma isozyme	221					cell division|glycogen metabolic process|mitotic prometaphase|triglyceride catabolic process	cleavage furrow|condensed chromosome kinetochore|cytosol|midbody|MLL5-L complex|nuclear speck|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|protein binding|protein kinase binding|protein serine/threonine phosphatase activity			central_nervous_system(1)|large_intestine(2)|lung(3)	6						GGACACTCCTCTGTCATTTTC	0.413000													40	130					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13605215	13605215	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:13605215C>A	ENST00000040738.5	-	10	3444	c.3309G>T	c.(3307-3309)caG>caT	p.Q1103H		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1103							DNA binding										TTTTTGGTCTCTGAAGGGAGG	0.423000													27	84					3.99451e-17	4.44038e-17	1	1	0
SYTL1	84958	broad.mit.edu	37	1	27676499	27676499	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:27676499G>A	ENST00000543823.1	+	8	1246	c.784G>A	c.(784-786)Gag>Aag	p.E262K	SYTL1_ENST00000490170.1_3'UTR|SYTL1_ENST00000318074.5_Missense_Mutation_p.E250K			Q8IYJ3	SYTL1_HUMAN	synaptotagmin-like 1	262					exocytosis|intracellular protein transport	extrinsic to plasma membrane|melanosome|soluble fraction	neurexin binding|Rab GTPase binding			NS(1)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	12		Colorectal(325;0.000147)|all_lung(284;0.000366)|Lung NSC(340;0.000548)|Renal(390;0.00211)|Breast(348;0.0115)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0908)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-28)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.0013)|KIRC - Kidney renal clear cell carcinoma(1967;0.00158)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AGGCGACGCGGAGGCGGTGCA	0.751000													7	10					0	0	1	0	0
BRIP1	83990	broad.mit.edu	37	17	59760869	59760869	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:59760869C>G	ENST00000259008.2	-	20	3805	c.3538G>C	c.(3538-3540)Gat>Cat	p.D1180H		NM_032043.2	NP_114432.2	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	1180					DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			NS(1)|breast(3)|endometrium(9)|kidney(5)|large_intestine(9)|liver(2)|lung(15)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	55						CTGGCTGAATCTACTTCTTTT	0.323000			"""F, N, Mis"""			"""AML, leukemia, breast"""		Involved in tolerance or repair of DNA crosslinks					12	62					0	0	1	0	0
UBE2C	11065	broad.mit.edu	37	20	44443062	44443062	+	Missense_Mutation	SNP	G	G	C	rs144831911	by1000genomes	TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:44443062G>C	ENST00000405520.1	+	2	889	c.52G>C	c.(52-54)Gac>Cac	p.D18H	UBE2C_ENST00000352551.5_Intron|UBE2C_ENST00000335046.3_Missense_Mutation_p.D57H|UBE2C_ENST00000372568.4_Missense_Mutation_p.D18H|UBE2C_ENST00000243893.6_Intron|UBE2C_ENST00000496085.1_3'UTR|UBE2C_ENST00000356455.4_Missense_Mutation_p.D57H	NM_181802.1	NP_861518.1	O00762	UBE2C_HUMAN	ubiquitin-conjugating enzyme E2C	57					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|cyclin catabolic process|exit from mitosis|free ubiquitin chain polymerization|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|positive regulation of exit from mitosis|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination|protein K48-linked ubiquitination|spindle organization	anaphase-promoting complex|cytosol|nucleoplasm	ATP binding|protein binding|ubiquitin-protein ligase activity			large_intestine(2)|lung(2)|skin(1)	5		Myeloproliferative disorder(115;0.0122)				CCCTGAATCAGACAACCTTTT	0.493000													12	66					0	0	1	0	0
EXOC1	55763	broad.mit.edu	37	4	56734553	56734553	+	Missense_Mutation	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:56734553T>C	ENST00000381295.2	+	5	815	c.467T>C	c.(466-468)gTa>gCa	p.V156A	EXOC1_ENST00000349598.6_Missense_Mutation_p.V156A|EXOC1_ENST00000346134.7_Missense_Mutation_p.V156A	NM_001024924.1	NP_001020095.1	Q9NV70	EXOC1_HUMAN	exocyst complex component 1	156					exocytosis|protein transport	exocyst	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)|skin(4)|upper_aerodigestive_tract(1)	35	Glioma(25;0.08)|all_neural(26;0.101)					GATGAAGAAGTAGTAGATGAA	0.358000													11	37					0	0	1	0	0
MSGN1	343930	broad.mit.edu	37	2	17998209	17998209	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:17998209G>C	ENST00000281047.3	+	1	447	c.424G>C	c.(424-426)Gat>Cat	p.D142H		NM_001105569.1	NP_001099039.1	A6NI15	MSGN1_HUMAN	mesogenin 1	142	Helix-loop-helix motif.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					GACCTTGGCAGATGCCCTGCA	0.582000													23	62					0	0	1	0	0
ITLN2	142683	broad.mit.edu	37	1	160920406	160920406	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:160920406C>T	ENST00000368029.3	-	5	594	c.537G>A	c.(535-537)ctG>ctA	p.L179L	ITLN2_ENST00000494442.1_5'UTR	NM_080878.2	NP_543154.1	Q8WWU7	ITLN2_HUMAN	intelectin 2	179	Fibrinogen C-terminal.				signal transduction	extracellular region	receptor binding|sugar binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(1)	19	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			TGCGGTACCTCAGCAGGGCGC	0.577000													25	210					0	0	1	0	0
DYNC1H1	1778	broad.mit.edu	37	14	102486382	102486382	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:102486382C>A	ENST00000360184.4	+	42	8660	c.8496C>A	c.(8494-8496)ctC>ctA	p.L2832L		NM_001376.4	NP_001367.2	Q14204	DYHC1_HUMAN	dynein, cytoplasmic 1, heavy chain 1	2832					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(5)|cervix(1)|endometrium(21)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(28)|lung(60)|ovary(9)|pancreas(1)|prostate(6)|skin(7)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	166						CTCTGCGTCTCTTCCAAGATA	0.552000													5	56					1.23904e-05	1.28134e-05	1	1	0
ACER2	340485	broad.mit.edu	37	9	19450460	19450460	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:19450460C>G	ENST00000340967.2	+	6	680	c.654C>G	c.(652-654)atC>atG	p.I218M		NM_001010887.2	NP_001010887.2	Q5QJU3	ACER2_HUMAN	alkaline ceramidase 2	218					ceramide metabolic process|negative regulation of cell adhesion mediated by integrin|negative regulation of cell-matrix adhesion|negative regulation of protein glycosylation in Golgi|positive regulation of cell proliferation|response to retinoic acid|sphingosine biosynthetic process	integral to Golgi membrane	ceramidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)	13						ACATCCTCATCTGCCTTGCTG	0.542000													32	87					0	0	1	0	0
YY1AP1	55249	broad.mit.edu	37	1	155638424	155638424	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:155638424G>A	ENST00000368340.5	-	8	1335	c.1227C>T	c.(1225-1227)atC>atT	p.I409I	YY1AP1_ENST00000535662.1_Silent_p.I137I|YY1AP1_ENST00000361831.5_Silent_p.I280I|MSTO1_ENST00000452804.2_Intron|YY1AP1_ENST00000404643.1_Silent_p.I271I|YY1AP1_ENST00000355499.4_Silent_p.I291I|YY1AP1_ENST00000295566.4_Silent_p.I337I|YY1AP1_ENST00000368330.2_Silent_p.I291I|YY1AP1_ENST00000407221.1_Silent_p.I260I|YY1AP1_ENST00000405763.3_Silent_p.I429I|YY1AP1_ENST00000368339.5_Silent_p.I429I|MSTO1_ENST00000538143.1_Intron|YY1AP1_ENST00000359205.5_Silent_p.I280I|YY1AP1_ENST00000311573.5_Silent_p.I260I|YY1AP1_ENST00000347088.5_Silent_p.I291I	NM_001198904.1	NP_001185833.1			YY1 associated protein 1											central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(7)|ovary(2)|skin(2)|urinary_tract(2)	31	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TCACTTTAATGATGTTGTCAG	0.418000													28	144					0	0	1	0	0
RSL1D1	26156	broad.mit.edu	37	16	11945367	11945367	+	Translation_Start_Site	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:11945367C>T	ENST00000571133.1	-	1	75	c.3G>A	c.(1-3)atG>atA	p.M1I	RSL1D1_ENST00000542106.1_5'UTR	NM_015659.2	NP_056474.2	O76021	RL1D1_HUMAN	ribosomal L1 domain containing 1	1					regulation of protein localization|translation	large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome			NS(1)|breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	15						CCGAATCCTCCATCTTGTTTC	0.657000													26	31					0	0	1	0	0
CHRNA10	57053	broad.mit.edu	37	11	3688461	3688461	+	Splice_Site	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:3688461C>A	ENST00000250699.2	-	4	967		c.e4+1		CHRNA10_ENST00000534359.1_Splice_Site	NM_020402.2	NP_065135.2	Q9GZZ6	ACH10_HUMAN	cholinergic receptor, nicotinic, alpha 10 (neuronal)						elevation of cytosolic calcium ion concentration|regulation of cell proliferation|synaptic transmission, cholinergic	cell junction|postsynaptic membrane	calcium channel activity|receptor activity|receptor binding			breast(1)|endometrium(2)|lung(3)|ovary(1)	7		Medulloblastoma(188;0.0075)|Breast(177;0.0164)|all_neural(188;0.0577)		BRCA - Breast invasive adenocarcinoma(625;0.0344)|LUSC - Lung squamous cell carcinoma(625;0.192)	Chloroprocaine(DB01161)|Methadone(DB00333)|Nicotine(DB00184)|Pentolinium(DB01090)|Procaine(DB00721)|Trimethaphan(DB01116)	CCGCTGCTCACCGATGAGCGG	0.721000													8	11					5.18039e-06	5.39562e-06	1	1	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													4	114					0	0	1	0	0
INMT	11185	broad.mit.edu	37	7	30795195	30795195	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:30795195G>C	ENST00000013222.5	+	3	536	c.520G>C	c.(520-522)Gat>Cat	p.D174H	INMT_ENST00000484180.1_3'UTR|INMT_ENST00000409539.1_Missense_Mutation_p.D173H|INMT-FAM188B_ENST00000458257.1_Intron	NM_001199219.1|NM_006774.4	NP_001186148.1|NP_006765.4	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	174						cytoplasm	amine N-methyltransferase activity			kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|stomach(1)	23						CTGTAGCCTTGATGCCTACCG	0.657000													30	141					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119426384	119426384	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:119426384G>C	ENST00000273390.5	+	3	412	c.335G>C	c.(334-336)aGa>aCa	p.R112T	MAATS1_ENST00000463700.1_Missense_Mutation_p.R112T	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		GAGAAACACAGAGAAGCCCTC	0.438000													8	91					0	0	1	0	0
USP47	55031	broad.mit.edu	37	11	11977639	11977639	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:11977639C>T	ENST00000339865.5	+	27	4544	c.3781C>T	c.(3781-3783)Cgt>Tgt	p.R1261C	USP47_ENST00000539466.1_Missense_Mutation_p.R131C|USP47_ENST00000527733.1_Missense_Mutation_p.R1329C|USP47_ENST00000305481.6_3'UTR|USP47_ENST00000399455.2_Missense_Mutation_p.R1349C	NM_017944.3	NP_060414.3	Q96K76	UBP47_HUMAN	ubiquitin specific peptidase 47	1349					base-excision repair|cellular response to UV|monoubiquitinated protein deubiquitination|negative regulation of apoptosis|negative regulation of caspase activity|negative regulation of G2/M transition of mitotic cell cycle|negative regulation of transcription, DNA-dependent|positive regulation of cell growth|response to drug|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|WD40-repeat domain binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	46				Epithelial(150;0.000339)		GACTGGACATCGTGTAACATA	0.368000													33	114					0	0	1	0	0
PIPSL	266971	broad.mit.edu	37	10	95721112	95721112	+	RNA	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:95721112C>G	ENST00000480546.1	-	0	185					NR_002319.2																						GGCCTATTTTCTTGATGGGCA	0.537000													30	99					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42584270	42584270	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:42584270C>T	ENST00000600245.1	+	2	2167	c.1512C>T	c.(1510-1512)ttC>ttT	p.F504F	ZNF574_ENST00000222339.7_Silent_p.F594F|ZNF574_ENST00000359044.4_Silent_p.F504F			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				GCAAGATGTTCAAGAAGAAGT	0.582000													161	432					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53186105	53186105	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:53186105C>A	ENST00000417996.2	-	5	1180	c.1106G>T	c.(1105-1107)aGc>aTc	p.S369I	KRT3_ENST00000309505.3_Missense_Mutation_p.S369I	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	369	Linker 12.|Rod.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						AGCAATGATGCTGTCCAGGTC	0.537000													33	45					2.42023e-17	2.6945e-17	1	1	0
ZNF343	79175	broad.mit.edu	37	20	2473393	2473393	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:2473393G>A	ENST00000278772.4	-	5	743	c.256C>T	c.(256-258)Cta>Tta	p.L86L	ZNF343_ENST00000381253.1_Silent_p.L86L|ZNF343_ENST00000358413.2_Silent_p.L86L|RP4-734P14.4_ENST00000461548.1_Silent_p.L86L	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	86	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						TCTTTGTATAGATTCCTCTGC	0.393000													37	180					0	0	1	0	0
MLEC	9761	broad.mit.edu	37	12	121125205	121125205	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:121125205G>A	ENST00000228506.3	+	1	534	c.106G>A	c.(106-108)Gtg>Atg	p.V36M	MLEC_ENST00000412616.2_Missense_Mutation_p.V36M	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	36					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						CGTggccggcgtggccggcgc	0.746000													3	11					0	0	1	0	0
MTPAP	55149	broad.mit.edu	37	10	30653968	30653968	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:30653968C>G	ENST00000358107.4	-	2	213	c.214G>C	c.(214-216)Gag>Cag	p.E72Q	MTPAP_ENST00000488290.1_5'UTR			Q9NVV4	PAPD1_HUMAN	mitochondrial poly(A) polymerase	0					cell death|histone mRNA catabolic process|mRNA polyadenylation|transcription, DNA-dependent	mitochondrion	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|protein homodimerization activity|RNA binding|UTP binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	33						GCGCTGCCCTCTGGCCCTCGT	0.627000													3	29					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62593719	62593719	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:62593719G>T	ENST00000371158.2	+	40	5233	c.5119G>T	c.(5119-5121)Gcc>Tcc	p.A1707S	INADL_ENST00000472512.1_3'UTR	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1707	PDZ 10.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CGTATTTATTGCCATGATTCA	0.463000													19	72					4.35082e-09	4.62433e-09	1	1	0
TP53	7157	broad.mit.edu	37	17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	rs112431538		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:7577085C>T	ENST00000420246.2	-	8	985	c.853G>A	c.(853-855)Gag>Aag	p.E285K	TP53_ENST00000445888.2_Missense_Mutation_p.E285K|TP53_ENST00000269305.4_Missense_Mutation_p.E285K|TP53_ENST00000455263.2_Missense_Mutation_p.E285K|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.E285K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	285	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(111)|p.E285*(24)|p.0?(8)|p.E285Q(4)|p.?(2)|p.R283fs*16(2)|p.C275fs*20(1)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.T284_G293del10(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.G279fs*59(1)|p.R283fs*56(1)|p.E285fs*20(1)|p.E285fs*13(1)|p.R283fs*59(1)|p.V272_K292del21(1)|p.E285_N288delEEEN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	36					0	0	1	0	0
CWC25	54883	broad.mit.edu	37	17	36971177	36971177	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:36971177G>C	ENST00000225428.4	-	3	662	c.365C>G	c.(364-366)tCa>tGa	p.S122*	CWC25_ENST00000536127.1_Nonsense_Mutation_p.S59*	NM_017748.3	NP_060218.1	Q9NXE8	CWC25_HUMAN	CWC25 spliceosome-associated protein homolog (S. cerevisiae)	122										central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)	14						ATTGGCACCTGATGGGGCAAA	0.522000													20	75					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077787	9077787	+	Missense_Mutation	SNP	A	A	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:9077787A>T	ENST00000397910.4	-	3	9862	c.9659T>A	c.(9658-9660)aTc>aAc	p.I3220N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3221	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTGGACCTGATCTCTGGGCT	0.502000													41	152					0	0	1	0	0
JAG2	3714	broad.mit.edu	37	14	105614685	105614685	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:105614685C>T	ENST00000331782.3	-	16	2515	c.2112G>A	c.(2110-2112)tgG>tgA	p.W704*	JAG2_ENST00000347004.2_Nonsense_Mutation_p.W666*	NM_002226.4	NP_002217.3	Q9Y219	JAG2_HUMAN	jagged 2	704	EGF-like 12; calcium-binding (Potential).				auditory receptor cell fate commitment|cell communication|cell cycle|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation|spermatogenesis|thymic T cell selection	integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding			breast(2)|endometrium(2)|kidney(3)|large_intestine(1)|lung(7)|prostate(2)|skin(5)	22		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCTTGCCCTTCCAGCCGTCGT	0.697000													16	24					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63410529	63410529	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:63410529G>A	ENST00000330258.3	-	2	2910	c.2638C>T	c.(2638-2640)Cct>Tct	p.P880S	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									GGAGGTCGAGGGTGCAGGCCA	0.577000													3	36					0	0	1	0	0
PAQR6	79957	broad.mit.edu	37	1	156213735	156213735	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:156213735C>G	ENST00000335852.1	-	7	1588	c.973G>C	c.(973-975)Gag>Cag	p.E325Q	PAQR6_ENST00000368270.1_3'UTR|PAQR6_ENST00000292291.5_3'UTR|PAQR6_ENST00000360733.2_Missense_Mutation_p.E325Q|PAQR6_ENST00000492619.1_5'UTR|PAQR6_ENST00000356983.2_Missense_Mutation_p.E325Q|PAQR6_ENST00000540423.1_3'UTR	NM_024897.2	NP_079173.2	Q6TCH4	PAQR6_HUMAN	progestin and adipoQ receptor family member VI	0						integral to membrane	receptor activity			lung(4)|ovary(1)	5	Hepatocellular(266;0.158)					CGGTCCCTCTCACACTCTGCC	0.602000													66	452					0	0	1	0	0
SAMD12	401474	broad.mit.edu	37	8	119391929	119391929	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:119391929C>A	ENST00000409003.4	-	4	461	c.333G>T	c.(331-333)ctG>ctT	p.L111L	SAMD12_ENST00000314727.4_Silent_p.L111L|AC023590.1_ENST00000430457.1_Intron	NM_001101676.1	NP_001095146.1	Q8N8I0	SAM12_HUMAN	sterile alpha motif domain containing 12	111	SAM.									endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(2)	9	all_cancers(13;3.91e-25)|Lung NSC(37;1.13e-07)|Ovarian(258;0.0249)		STAD - Stomach adenocarcinoma(47;0.00391)			TAAGTCTCAGCAGGGCTCGCC	0.488000													54	94					1.72845e-40	1.99774e-40	1	1	0
NDFIP2	54602	broad.mit.edu	37	13	80107517	80107517	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:80107517C>G	ENST00000218652.7	+	3	599	c.547C>G	c.(547-549)Ctt>Gtt	p.L183V		NM_001161407.1|NM_019080.2	NP_001154879.1|NP_061953.2	Q9NV92	NFIP2_HUMAN	Nedd4 family interacting protein 2	183					negative regulation of gene expression|negative regulation of protein transport|negative regulation of transporter activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of protein ubiquitination	endoplasmic reticulum|Golgi membrane|integral to membrane|mitochondrion|multivesicular body membrane|perinuclear region of cytoplasm	signal transducer activity|WW domain binding			NS(1)|breast(1)|endometrium(2)|kidney(3)|lung(3)|ovary(2)|prostate(1)|skin(1)	14		Acute lymphoblastic leukemia(28;0.205)		GBM - Glioblastoma multiforme(99;0.0196)		TGCTACCTCTCTTCCTACATA	0.393000													10	58					0	0	1	0	0
MTHFR	4524	broad.mit.edu	37	1	11861279	11861279	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:11861279G>A	ENST00000376592.1	-	2	542	c.414C>T	c.(412-414)atC>atT	p.I138I	MTHFR_ENST00000376583.3_Silent_p.I179I|MTHFR_ENST00000376585.1_Silent_p.I179I|MTHFR_ENST00000376590.3_Silent_p.I138I			P42898	MTHR_HUMAN	methylenetetrahydrofolate reductase (NAD(P)H)	138					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding			NS(4)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	GATGGCCCGTGATCTCCTCCA	0.612000													49	158					0	0	1	0	0
ARHGEF19	128272	broad.mit.edu	37	1	16525664	16525664	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:16525664C>T	ENST00000270747.3	-	15	2368	c.2232G>A	c.(2230-2232)gtG>gtA	p.V744V	ARHGEF19_ENST00000478117.1_5'UTR|ARHGEF19_ENST00000421561.1_Intron	NM_153213.3	NP_694945.2	Q8IW93	ARHGJ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 19	744	SH3.				regulation of actin cytoskeleton organization	intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(1)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.018)|Colorectal(212;3.48e-07)|COAD - Colon adenocarcinoma(227;2.19e-05)|BRCA - Breast invasive adenocarcinoma(304;9.46e-05)|Kidney(64;0.000171)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(313;0.0117)|READ - Rectum adenocarcinoma(331;0.0649)		TCCAGGTCCTCACTGACAGGA	0.572000													13	82					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156626862	156626862	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:156626862C>A	ENST00000329117.4	+	10	2519	c.2183C>A	c.(2182-2184)aCa>aAa	p.T728K	BCAN_ENST00000496038.1_3'UTR|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	728	C-type lectin.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGCATCAGCACACCCGAGGAA	0.622000													31	86					1.90571e-15	2.08967e-15	1	1	0
LAMA5	3911	broad.mit.edu	37	20	60927004	60927004	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:60927004G>A	ENST00000252999.3	-	5	885	c.819C>T	c.(817-819)ctC>ctT	p.L273L	LAMA5_ENST00000370692.3_Silent_p.L273L|LAMA5_ENST00000370677.3_Silent_p.L273L	NM_005560.3	NP_005551.3	O15230	LAMA5_HUMAN	laminin, alpha 5	273	Laminin N-terminal.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|lung(40)|ovary(1)|pancreas(1)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	81	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTTCCCCATGAGATGGCCCA	0.692000													13	55					0	0	1	0	0
ACO2	50	broad.mit.edu	37	22	41919918	41919918	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:41919918G>A	ENST00000396512.3	+	12	1547	c.1530G>A	c.(1528-1530)gaG>gaA	p.E510E	ACO2_ENST00000216254.4_Silent_p.E485E			Q99798	ACON_HUMAN	aconitase 2, mitochondrial	485					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(3)|endometrium(5)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	23						CAAACCCCGAGACCCATGCCT	0.617000													25	82					0	0	1	0	0
CMTR1	23070	broad.mit.edu	37	6	37427352	37427352	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:37427352G>A	ENST00000373451.4	+	10	1151	c.987G>A	c.(985-987)ggG>ggA	p.G329G		NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		329					mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						GTGAGGGTGGGATTGATGGAG	0.498000													33	121					0	0	1	0	0
LENG1	79165	broad.mit.edu	37	19	54660593	54660593	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:54660593C>A	ENST00000222224.3	-	3	669	c.483G>T	c.(481-483)caG>caT	p.Q161H		NM_024316.1	NP_077292.1	Q96BZ8	LENG1_HUMAN	leukocyte receptor cluster (LRC) member 1	161										breast(1)|endometrium(3)|large_intestine(2)|lung(1)|ovary(1)	8	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCAGATGCTTCTGCATCTCCC	0.627000													33	81					5.8336e-16	6.40639e-16	1	1	0
NRK	203447	broad.mit.edu	37	X	105181572	105181572	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:105181572C>T	ENST00000428173.2	+	22	4103	c.3800C>T	c.(3799-3801)tCa>tTa	p.S1267L	NRK_ENST00000243300.9_Missense_Mutation_p.S1266L			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1266	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						ATTACCATCTCAGGTTTGTTT	0.378000										HNSCC(51;0.14)			11	8					0	0	1	0	0
SDF4	51150	broad.mit.edu	37	1	1154297	1154297	+	Silent	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:1154297G>T	ENST00000263741.7	-	5	880	c.588C>A	c.(586-588)gtC>gtA	p.V196V	SDF4_ENST00000360001.6_Silent_p.V196V	NM_016176.3|NM_016547.2	NP_057260.2|NP_057631.1	Q9BRK5	CAB45_HUMAN	stromal cell derived factor 4	196					cerebellum development|fat cell differentiation|response to ethanol|UV protection|zymogen granule exocytosis	bleb|Golgi lumen|late endosome|soluble fraction	calcium ion binding|identical protein binding|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;7.85e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.42e-21)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;4.83e-05)|Kidney(185;0.00252)|BRCA - Breast invasive adenocarcinoma(365;0.00263)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0368)|Lung(427;0.204)		GGTTCTCCAGGACTTCCTGTG	0.632000													55	212					5.82089e-37	6.69587e-37	1	1	0
EIF4ENIF1	56478	broad.mit.edu	37	22	31858990	31858990	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:31858990C>G	ENST00000397525.1	-	6	938	c.715G>C	c.(715-717)Gat>Cat	p.D239H	EIF4ENIF1_ENST00000397523.1_Missense_Mutation_p.D239H|RP11-247I13.11_ENST00000464523.1_RNA|EIF4ENIF1_ENST00000344710.5_Intron|EIF4ENIF1_ENST00000330125.5_Missense_Mutation_p.D239H|RP11-247I13.11_ENST00000483736.1_RNA|RP11-247I13.8_ENST00000439588.1_RNA	NM_001164501.1	NP_001157973.1	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E nuclear import factor 1	239						nucleus	protein binding|protein transporter activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						ATCTTATCATCAAAGCCAGTC	0.453000													23	53					0	0	1	0	0
LIPE	3991	broad.mit.edu	37	19	42906899	42906899	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:42906899C>T	ENST00000244289.4	-	9	3103	c.2827G>A	c.(2827-2829)Gag>Aag	p.E943K	LIPE-AS1_ENST00000599276.1_RNA|LIPE-AS1_ENST00000597203.1_RNA|LIPE-AS1_ENST00000594624.2_RNA|LIPE-AS1_ENST00000593491.2_RNA	NM_005357.2	NP_005348.2	Q05469	LIPS_HUMAN	lipase, hormone-sensitive	943					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			breast(2)|endometrium(4)|kidney(7)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	32		Prostate(69;0.00682)				TGGAAACCCTCGGGGAAGGCG	0.617000													15	58					0	0	1	0	0
HELQ	113510	broad.mit.edu	37	4	84376606	84376606	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:84376606C>T	ENST00000295488.3	-	1	403	c.241G>A	c.(241-243)Gat>Aat	p.D81N	HELQ_ENST00000510985.1_Missense_Mutation_p.D81N|HELQ_ENST00000440639.2_5'UTR	NM_133636.2	NP_598375.2	Q8TDG4	HELQ_HUMAN	helicase, POLQ-like	81							ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(17)|ovary(2)|skin(2)	38						GGGTTTGTATCACCACCTCCA	0.567000								Other identified genes with known or suspected DNA repair function					38	158					0	0	1	0	0
KIAA2026	158358	broad.mit.edu	37	9	6007726	6007726	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:6007726G>A	ENST00000399933.3	-	1	61	c.62C>T	c.(61-63)cCg>cTg	p.P21L	KIAA2026_ENST00000381461.2_Missense_Mutation_p.P21L	NM_001017969.2	NP_001017969.2	Q5HYC2	K2026_HUMAN	KIAA2026	21										breast(6)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(11)|lung(15)|ovary(2)|prostate(2)|skin(1)	46		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTCGGCCGCCGGTGGCGGCCG	0.746000													4	18					0	0	1	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633819	70633819	+	Missense_Mutation	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:70633819T>C	ENST00000381269.2	-	2	2074	c.1321A>G	c.(1321-1323)Aat>Gat	p.N441D	SLC8A3_ENST00000534137.1_Missense_Mutation_p.N441D|SLC8A3_ENST00000528359.1_Missense_Mutation_p.N441D|SLC8A3_ENST00000357887.3_Missense_Mutation_p.N441D|SLC8A3_ENST00000356921.2_Missense_Mutation_p.N441D	NM_058240.2|NM_183002.1	NP_489479.1|NP_892114.1	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 3	441	Calx-beta 1.				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(18)|ovary(2)|pancreas(2)|prostate(3)|skin(6)	54				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		GCCCCTGCATTGGCAGAACCA	0.517000													31	276					0	0	1	0	0
ISCU	23479	broad.mit.edu	37	12	108957910	108957910	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:108957910G>C	ENST00000338291.4	+	2	206	c.18G>C	c.(16-18)atG>atC	p.M6I	ISCU_ENST00000539593.1_Intron|ISCU_ENST00000392807.4_Missense_Mutation_p.M6I|ISCU_ENST00000535729.1_Intron|ISCU_ENST00000431221.2_Intron|ISCU_ENST00000311893.9_Intron|ISCU_ENST00000547005.1_Intron			Q9H1K1	ISCU_HUMAN	iron-sulfur cluster assembly enzyme	0					iron-sulfur cluster assembly|nitrogen fixation	cytosol|mitochondrion|nucleus	iron ion binding|iron-sulfur cluster binding|protein complex scaffold	p.M6I(1)		kidney(2)|large_intestine(2)|lung(4)|prostate(2)|urinary_tract(1)	11						TCATTGACATGAGTGTAGACC	0.403000													17	140					0	0	1	0	0
SLC19A2	10560	broad.mit.edu	37	1	169439325	169439325	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:169439325C>A	ENST00000236137.5	-	3	1143	c.907G>T	c.(907-909)Gcc>Tcc	p.A303S	SLC19A2_ENST00000367802.3_Missense_Mutation_p.A265S|SLC19A2_ENST00000367804.3_Missense_Mutation_p.A102S	NM_006996.2	NP_008927.1	O60779	S19A2_HUMAN	solute carrier family 19 (thiamine transporter), member 2	303					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|folic acid transporter activity|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|upper_aerodigestive_tract(1)	11	all_hematologic(923;0.208)					GTAGAGAGGGCCCACCACACA	0.502000													14	135					0.000151284	0.000155125	1	1	0
TMC4	147798	broad.mit.edu	37	19	54665951	54665951	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:54665951C>T	ENST00000376591.4	-	11	1722	c.1591G>A	c.(1591-1593)Gag>Aag	p.E531K	TMC4_ENST00000301187.4_Missense_Mutation_p.E525K|TMC4_ENST00000416963.1_Missense_Mutation_p.E113K	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	531						integral to membrane		p.E113K(1)|p.E525K(1)		breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCCAGCACCTCGTCGGGCACC	0.652000													6	28					0	0	1	0	0
DNAAF2	55172	broad.mit.edu	37	14	50100257	50100257	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:50100257G>A	ENST00000298292.8	-	1	1691	c.1611C>T	c.(1609-1611)ctC>ctT	p.L537L	DNAAF2_ENST00000406043.3_Silent_p.L537L	NM_018139.2	NP_060609.2	Q9NVR5	KTU_HUMAN	dynein, axonemal, assembly factor 2	537					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm				kidney(1)|lung(4)	5						GCACCTGAATGAGCAGAGTCA	0.522000													6	68					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735121	140735121	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:140735121G>A	ENST00000571252.1	+	1	354	c.354G>A	c.(352-354)cgG>cgA	p.R118R	PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATTTTGCGGGTAGAGGTGG	0.448000													12	58					0	0	1	0	0
DNAH12	201625	broad.mit.edu	37	3	57488152	57488152	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:57488152C>T	ENST00000351747.2	-	10	1321	c.1141G>A	c.(1141-1143)Gac>Aac	p.D381N	DNAH12_ENST00000311202.6_Missense_Mutation_p.D381N|DNAH12_ENST00000389536.4_Missense_Mutation_p.D381N	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	381	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						AGTTCTGTGTCAAGATTTACT	0.373000													38	95					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114170951	114170951	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:114170951G>A	ENST00000357077.4	+	10	976	c.923G>A	c.(922-924)cGa>cAa	p.R308Q	ANK2_ENST00000264366.6_Missense_Mutation_p.R308Q|ANK2_ENST00000506722.1_Missense_Mutation_p.R287Q|ANK2_ENST00000394537.3_Missense_Mutation_p.R308Q	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	308					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGTGCTGCACGAAGTGGGCAT	0.458000													10	32					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49750010	49750010	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:49750010C>T	ENST00000327697.6	+	27	2739	c.2595C>T	c.(2593-2595)ttC>ttT	p.F865F	RNF123_ENST00000432042.1_Silent_p.F719F	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	865						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		TGCCCGAGTTCTACCTGAGCG	0.562000													35	100					0	0	1	0	0
CHST9	83539	broad.mit.edu	37	18	24496409	24496409	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:24496409C>T	ENST00000284224.8	-	6	1423	c.1146G>A	c.(1144-1146)caG>caA	p.Q382Q	AQP4-AS1_ENST00000579964.1_RNA|AQP4-AS1_ENST00000582605.1_RNA|CHST9_ENST00000580774.1_3'UTR|CHST9_ENST00000581714.1_Silent_p.Q382Q|AQP4-AS1_ENST00000568797.1_RNA|AQP4-AS1_ENST00000578701.1_RNA	NM_031422.5	NP_113610.2	Q7L1S5	CHST9_HUMAN	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9	382					carbohydrate biosynthetic process|glycosaminoglycan metabolic process|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	extracellular region|Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(7)|ovary(2)|pancreas(1)|skin(3)	28	all_lung(6;0.0145)|Ovarian(20;0.124)					CACCGATCATCTGTAAAAAGT	0.403000													45	166					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22168096	22168096	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:22168096G>C	ENST00000374695.3	-	70	9343	c.9264C>G	c.(9262-9264)acC>acG	p.T3088T		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	3088	Ig-like C2-type 16.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGCAGCGGTAGGTACCGTGGT	0.622000													28	83					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48517101	48517101	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:48517101C>T	ENST00000358350.4	-	56	8485	c.7881G>A	c.(7879-7881)ctG>ctA	p.L2627L	FRYL_ENST00000264319.7_Silent_p.L23L|FRYL_ENST00000507873.2_Silent_p.L23L|FRYL_ENST00000503238.1_Silent_p.L2627L|FRYL_ENST00000537810.1_Silent_p.L2627L	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	2627					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CTAGCTCTTTCAGAGCTAAGG	0.428000													37	108					0	0	1	0	0
CLVS2	134829	broad.mit.edu	37	6	123377169	123377169	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:123377169G>A	ENST00000275162.4	+	5	2229	c.894G>A	c.(892-894)aaG>aaA	p.K298K	CLVS2_ENST00000368438.1_Silent_p.K152K	NM_001010852.2	NP_001010852.2	Q5SYC1	CLVS2_HUMAN	clavesin 2	298					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	40						AGTCCATGAAGAGGTATGCTG	0.483000													3	10					0	0	1	0	0
ALOX5AP	241	broad.mit.edu	37	13	31309752	31309752	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:31309752G>C	ENST00000380490.3	+	1	108	c.10G>C	c.(10-12)Gaa>Caa	p.E4Q		NM_001204406.1|NM_001629.3	NP_001191335.1|NP_001620.2	P20292	AL5AP_HUMAN	arachidonate 5-lipoxygenase-activating protein	4					cellular response to calcium ion|leukotriene biosynthetic process|leukotriene production involved in inflammatory response|protein homotrimerization	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	arachidonic acid binding|protein N-terminus binding			endometrium(1)|large_intestine(1)|ovary(1)|prostate(1)	4		Lung SC(185;0.0257)|Breast(139;0.203)		all cancers(112;0.0187)|Epithelial(112;0.0803)|OV - Ovarian serous cystadenocarcinoma(117;0.0864)		CATGGATCAAGAAACTGTAGG	0.537000													7	48					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222826630	222826630	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:222826630C>G	ENST00000344922.5	+	15	4295	c.4270C>G	c.(4270-4272)Caa>Gaa	p.Q1424E	MIA3_ENST00000344441.6_Missense_Mutation_p.Q1424E|MIA3_ENST00000340535.7_Missense_Mutation_p.Q302E|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1424					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		ATCTGAGGGTCAAAATAAAGG	0.398000													23	54					0	0	1	0	0
GGNBP2	79893	broad.mit.edu	37	17	34916666	34916666	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:34916666G>C	ENST00000304718.4	+	5	798	c.482G>C	c.(481-483)aGa>aCa	p.R161T		NM_024835.3	NP_079111.1	Q9H3C7	GGNB2_HUMAN	gametogenetin binding protein 2	161					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasmic membrane-bounded vesicle				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)	38		Breast(25;0.00957)|Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0193)		AAGAATAAGAGATGTCAGTTG	0.303000													10	93					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21727128	21727128	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:21727128C>T	ENST00000328843.6	+	35	5959	c.5928C>T	c.(5926-5928)atC>atT	p.I1976I	DNAH11_ENST00000409508.3_Silent_p.I1969I			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1976	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						ATGATGCCATCAGAAACAGGA	0.448000									Kartagener syndrome				7	28					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3235275	3235275	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:3235275C>G	ENST00000217939.6	-	6	6601	c.6447G>C	c.(6445-6447)acG>acC	p.T2149T		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2149	Ig-like C2-type 6.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GGGAGGTGCCCGTGATGCGCG	0.706000													19	10					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231157404	231157404	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:231157404C>T	ENST00000392045.3	+	20	1983	c.1869C>T	c.(1867-1869)ttC>ttT	p.F623F	SP140_ENST00000350136.5_Silent_p.F492F|SP140_ENST00000343805.6_Silent_p.F563F|SP140_ENST00000417495.3_Silent_p.F509F|SP140_ENST00000420434.3_Silent_p.F596F|SP140_ENST00000486687.2_Silent_p.F547F	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	623	SAND.				defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GAAAATGGTTCACCCCCACGG	0.512000													33	152					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67872874	67872874	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:67872874G>A	ENST00000255674.6	-	1	307	c.21C>T	c.(19-21)atC>atT	p.I7I	RTTN_ENST00000454359.1_Silent_p.I7I|RTTN_ENST00000437017.1_Silent_p.I7I	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	7							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				CGAGTTTCCTGATGAGCCCTG	0.627000													31	66					0	0	1	0	0
EMC4	51234	broad.mit.edu	37	15	34521955	34521955	+	Splice_Site	SNP	G	G	C	rs138144365		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:34521955G>C	ENST00000267750.4	+	5	634	c.516_splice	c.e5-1	p.R173_splice	EMC4_ENST00000559421.1_Splice_Site_p.R68_splice|EMC4_ENST00000249209.4_Splice_Site_p.K119_splice	NM_016454.2	NP_057538.1			ER membrane protein complex subunit 4																		TTCTTTCAGAGAATGGAGTTC	0.373000													28	50					0	0	1	0	0
LRRC23	10233	broad.mit.edu	37	12	7014918	7014918	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:7014918G>A	ENST00000007969.8	+	2	341	c.121G>A	c.(121-123)Gag>Aag	p.E41K	LRRC23_ENST00000429740.1_Missense_Mutation_p.E41K|LRRC23_ENST00000449039.1_3'UTR|LRRC23_ENST00000433346.1_Missense_Mutation_p.E41K|LRRC23_ENST00000323702.5_Missense_Mutation_p.E41K|LRRC23_ENST00000443597.2_Missense_Mutation_p.E41K|LRRC23_ENST00000436789.1_Missense_Mutation_p.E41K	NM_001135217.1|NM_201650.2	NP_001128689.1|NP_964013.1	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	41										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						agagTTCCCTGAGGAAGTGAG	0.567000													5	94					0	0	1	0	0
GPR15	2838	broad.mit.edu	37	3	98251868	98251868	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:98251868G>A	ENST00000284311.3	+	1	1126	c.991G>A	c.(991-993)Gag>Aag	p.E331K		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	331						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		GAGTAGCACTGAGACATCAGA	0.478000													23	88					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769092	57769092	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:57769092G>C	ENST00000371030.2	+	1	3018	c.3018G>C	c.(3016-3018)gaG>gaC	p.E1006D		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1006						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCATCCTGGAGGACCCCAGCT	0.642000													15	72					0	0	1	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113212649	113212649	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:113212649G>C	ENST00000261965.3	-	5	595	c.409C>G	c.(409-411)Cag>Gag	p.Q137E	TUBGCP3_ENST00000375669.3_Missense_Mutation_p.Q137E	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	137					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					GGAAGGGTCTGAGGCCTGGCA	0.552000													20	68					0	0	1	0	0
KBTBD12	166348	broad.mit.edu	37	3	127642850	127642850	+	Missense_Mutation	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:127642850T>C	ENST00000405109.1	+	2	1413	c.946T>C	c.(946-948)Tac>Cac	p.Y316H	KBTBD12_ENST00000407609.3_Intron|KBTBD12_ENST00000343941.4_Intron|KBTBD12_ENST00000405256.1_Missense_Mutation_p.Y316H			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	316										endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						ATCTCCCAAGTACGGAGAGGG	0.408000													4	161					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66480257	66480257	+	Silent	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:66480257G>T	ENST00000256447.4	-	3	571	c.414C>A	c.(412-414)tcC>tcA	p.S138S		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	138					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		ACTCGAGATTGGATATTCCCG	0.418000													33	179					6.53348e-20	7.3187e-20	1	1	0
SERPINA9	327657	broad.mit.edu	37	14	94931141	94931141	+	Missense_Mutation	SNP	A	A	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:94931141A>T	ENST00000337425.5	-	4	1081	c.1007T>A	c.(1006-1008)cTg>cAg	p.L336Q	SERPINA9_ENST00000380365.3_Missense_Mutation_p.L318Q|SERPINA9_ENST00000298845.7_Missense_Mutation_p.L236Q|SERPINA9_ENST00000546329.1_Missense_Mutation_p.L300Q|SERPINA9_ENST00000448305.2_Missense_Mutation_p.L238Q|SERPINA9_ENST00000424550.2_Missense_Mutation_p.L187Q	NM_175739.3	NP_783866.2	Q86WD7	SPA9_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9	318					regulation of proteolysis	cytoplasm|extracellular region|membrane	serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(17)	21		all_cancers(154;0.0691)|all_epithelial(191;0.233)		Epithelial(152;0.144)|COAD - Colon adenocarcinoma(157;0.224)|all cancers(159;0.24)		GATGGTTTCCAGATTGTAGGA	0.453000													32	77					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23891511	23891511	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:23891511C>T	ENST00000355349.3	-	25	3285	c.3123G>A	c.(3121-3123)gaG>gaA	p.E1041E		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1041					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCACCTTCTTCTCTTGCTCCA	0.562000													23	73					0	0	1	0	0
ARVCF	421	broad.mit.edu	37	22	19967650	19967650	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:19967650G>A	ENST00000263207.3	-	6	1303	c.1012C>T	c.(1012-1014)Cgg>Tgg	p.R338W	ARVCF_ENST00000406522.1_Missense_Mutation_p.R275W|ARVCF_ENST00000401994.1_Missense_Mutation_p.R275W|ARVCF_ENST00000344269.3_Missense_Mutation_p.R275W|ARVCF_ENST00000406259.1_Missense_Mutation_p.R338W	NM_001670.2	NP_001661.1	O00192	ARVC_HUMAN	armadillo repeat gene deleted in velocardiofacial syndrome	338					cell adhesion|multicellular organismal development		protein binding			NS(1)|cervix(1)|endometrium(3)|liver(1)|lung(4)|prostate(1)|urinary_tract(2)	13	Colorectal(54;0.0993)					CGCACCAGCCGGTCCAGGCTG	0.726000													3	34					0	0	1	0	0
CNBD2	140894	broad.mit.edu	37	20	34568410	34568410	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:34568410C>G	ENST00000373973.3	+	4	446	c.273C>G	c.(271-273)atC>atG	p.I91M	CNBD2_ENST00000538900.1_Missense_Mutation_p.I91M|CNBD2_ENST00000349339.1_Missense_Mutation_p.I91M					cyclic nucleotide binding domain containing 2																		CCATTCAGATCATGCAGAAGA	0.557000													29	104					0	0	1	0	0
GINS4	84296	broad.mit.edu	37	8	41399411	41399411	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:41399411G>A	ENST00000523277.2	+	7	735	c.568G>A	c.(568-570)Gag>Aag	p.E190K	GINS4_ENST00000518671.1_Missense_Mutation_p.E190K|RP11-360L9.4_ENST00000523081.1_RNA|RP11-360L9.7_ENST00000524133.1_RNA|GINS4_ENST00000276533.3_Missense_Mutation_p.E190K			Q9BRT9	SLD5_HUMAN	GINS complex subunit 4 (Sld5 homolog)	190	Important for GINS complex assembly.				DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				breast(1)|lung(2)|skin(1)	4	Ovarian(28;0.014)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.00732)|Lung NSC(58;0.0207)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00329)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			AGACACAGATGAGCAGAGGTG	0.498000													38	126					0	0	1	0	0
ZNF766	90321	broad.mit.edu	37	19	52785408	52785408	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:52785408G>C	ENST00000439461.1	+	2	106	c.63G>C	c.(61-63)gaG>gaC	p.E21D	ZNF766_ENST00000593612.1_Missense_Mutation_p.E36D|ZNF766_ENST00000359102.4_Missense_Mutation_p.E36D|ZNF766_ENST00000600821.1_Missense_Mutation_p.E16D|ZNF766_ENST00000599581.1_Missense_Mutation_p.E21D	NM_001010851.2	NP_001010851.1	Q5HY98	ZN766_HUMAN	zinc finger protein 766	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	17				GBM - Glioblastoma multiforme(134;0.00236)|OV - Ovarian serous cystadenocarcinoma(262;0.00871)		TCTCTCAGGAGGAGTGGAAAT	0.463000													96	252					0	0	1	0	0
PTPRH	5794	broad.mit.edu	37	19	55718105	55718105	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:55718105C>G	ENST00000376350.3	-	3	326	c.304G>C	c.(304-306)Gag>Cag	p.E102Q	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Missense_Mutation_p.E102Q	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	102	Fibronectin type-III 1.				apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CCGTCTTTCTCCACCCACACA	0.502000													52	239					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62321730	62321730	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:62321730C>A	ENST00000318100.4	+	26	3176	c.2349C>A	c.(2347-2349)ttC>ttA	p.F783L	RTEL1_ENST00000370018.3_Missense_Mutation_p.F783L|RTEL1_ENST00000508582.2_Missense_Mutation_p.F807L|RTEL1_ENST00000370003.1_Missense_Mutation_p.F28L|RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.F783L|RTEL1_ENST00000360203.5_Missense_Mutation_p.F783L			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	783					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CTGGCCCCTTCTTCTCCACCA	0.667000													15	60					6.94344e-10	7.42336e-10	1	1	0
GNRHR	2798	broad.mit.edu	37	4	68620010	68620010	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:68620010G>A	ENST00000226413.4	-	1	68	c.44C>T	c.(43-45)tCa>tTa	p.S15L	GNRHR_ENST00000420975.2_Missense_Mutation_p.S15L|RP11-453E17.1_ENST00000502758.1_RNA|RP11-453E17.1_ENST00000500538.2_RNA	NM_000406.2	NP_000397.1	P30968	GNRHR_HUMAN	gonadotropin-releasing hormone receptor	15					multicellular organismal development	integral to plasma membrane	gonadotropin-releasing hormone receptor activity			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|ovary(1)|urinary_tract(1)	13					Abarelix(DB00106)|Cetrorelix(DB00050)|Danazol(DB01406)|Gonadorelin(DB00644)|Leuprolide(DB00007)|Nafarelin(DB00666)	GTTGATGGCTGAACAGTGATT	0.468000													31	109					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99440549	99440549	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:99440549C>T	ENST00000287042.4	+	2	692	c.342C>T	c.(340-342)ttC>ttT	p.F114F	KCNS2_ENST00000521839.1_Silent_p.F114F	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	114						voltage-gated potassium channel complex	voltage-gated potassium channel activity			autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			ACGAGTTCTTCATTGACTCCT	0.547000													35	144					0	0	1	0	0
MGST3	4259	broad.mit.edu	37	1	165619077	165619077	+	Splice_Site	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:165619077G>C	ENST00000367889.3	+	2	433		c.e2-1		MGST3_ENST00000404549.1_Splice_Site|MGST3_ENST00000367884.1_Splice_Site|MGST3_ENST00000367886.2_Splice_Site|MGST3_ENST00000367885.1_Splice_Site|MGST3_ENST00000367883.1_Splice_Site|MGST3_ENST00000367888.4_Splice_Site	NM_004528.3	NP_004519.1	O14880	MGST3_HUMAN	microsomal glutathione S-transferase 3						leukotriene biosynthetic process|leukotriene production involved in inflammatory response|signal transduction|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glutathione peroxidase activity|glutathione transferase activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(1)	6	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Glutathione(DB00143)	TTCTTCCACAGACGCAAGATG	0.478000													14	108					0	0	1	0	0
NTRK2	4915	broad.mit.edu	37	9	87342834	87342834	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:87342834G>A	ENST00000304053.6	+	9	1602	c.1119G>A	c.(1117-1119)caG>caA	p.Q373Q	NTRK2_ENST00000395866.2_Silent_p.Q217Q|NTRK2_ENST00000359847.3_Silent_p.Q373Q|NTRK2_ENST00000395882.1_Silent_p.Q373Q|NTRK2_ENST00000376214.1_Silent_p.Q373Q|NTRK2_ENST00000323115.4_Silent_p.Q373Q|NTRK2_ENST00000376213.1_Silent_p.Q373Q|NTRK2_ENST00000277120.3_Silent_p.Q373Q|NTRK2_ENST00000376208.1_Silent_p.Q373Q	NM_001018065.2	NP_001018075.1	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	373					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	46						ATGAGAAACAGATTTCTGCTC	0.468000										TSP Lung(25;0.17)			11	72					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52439605	52439605	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:52439605G>T	ENST00000242819.4	+	2	387	c.91G>T	c.(91-93)Gca>Tca	p.A31S		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	31						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		GTCCCTGGCGGCATCCTCTCC	0.507000													19	111					8.00594e-06	8.30288e-06	1	1	0
CLTC	1213	broad.mit.edu	37	17	57744325	57744325	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:57744325C>G	ENST00000269122.3	+	13	2389	c.2115C>G	c.(2113-2115)ttC>ttG	p.F705L	CLTC_ENST00000579456.1_Intron|CLTC_ENST00000393043.1_Missense_Mutation_p.F705L	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	705	Heavy chain arm.|Proximal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TTGAATCTTTCAAGAGTTTTG	0.358000			T	"""ALK, TFE3"""	"""ALCL, renal """								20	68					0	0	1	0	0
NFE2L2	4780	broad.mit.edu	37	2	178098975	178098975	+	Missense_Mutation	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:178098975A>G	ENST00000397062.3	-	2	624	c.70T>C	c.(70-72)Tgg>Cgg	p.W24R	NFE2L2_ENST00000423513.1_Missense_Mutation_p.W8R|NFE2L2_ENST00000446151.2_Missense_Mutation_p.W8R|NFE2L2_ENST00000397063.4_Missense_Mutation_p.W8R|NFE2L2_ENST00000464747.1_Missense_Mutation_p.W8R	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	24					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.W24R(2)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCTTGCCTCCAAAGTATGTCA	0.348000			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			24	36					0	0	1	0	0
CCDC74B	91409	broad.mit.edu	37	2	130899725	130899725	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:130899725G>C	ENST00000392984.3	-	2	1574	c.831C>G	c.(829-831)gtC>gtG	p.V277V	CCDC74B_ENST00000310463.6_Silent_p.V175V|CCDC74B_ENST00000409943.3_Silent_p.V109V|CCDC74B_ENST00000409128.1_Silent_p.V151V			Q96LY2	CC74B_HUMAN	coiled-coil domain containing 74B	175										endometrium(2)|large_intestine(1)|lung(3)	6	Colorectal(110;0.1)					AGATGGACTTGACAGACTGGA	0.637000													9	99					0	0	1	0	0
ICAM1	3383	broad.mit.edu	37	19	10395578	10395578	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:10395578G>C	ENST00000264832.3	+	6	1625	c.1300G>C	c.(1300-1302)Gat>Cat	p.D434H	CTD-2369P2.5_ENST00000592893.1_RNA|ICAM1_ENST00000423829.2_Missense_Mutation_p.D212H	NM_000201.2	NP_000192.2	P05362	ICAM1_HUMAN	intercellular adhesion molecule 1	434	Ig-like C2-type 5.				adhesion to symbiont|heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|membrane to membrane docking|positive regulation of cellular extravasation|regulation of immune response|regulation of leukocyte mediated cytotoxicity|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell|virion attachment, binding of host cell surface receptor	extracellular space|integral to plasma membrane	integrin binding|transmembrane receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;2.81e-06)|all cancers(31;6.56e-06)		Natalizumab(DB00108)|Simvastatin(DB00641)	GTGTCTAAAGGATGGCACTTT	0.577000													21	57					0	0	1	0	0
KCNH7	90134	broad.mit.edu	37	2	163241412	163241412	+	Silent	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:163241412G>T	ENST00000332142.5	-	13	2847	c.2748C>A	c.(2746-2748)acC>acA	p.T916T		NM_033272.3	NP_150375.2	Q9NS40	KCNH7_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 7	916					regulation of transcription, DNA-dependent	integral to membrane	protein binding|signal transducer activity			NS(1)|biliary_tract(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(22)|lung(53)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	108					Ibutilide(DB00308)	AATGTCTTATGGTATCTGCAG	0.353000													31	138					3.17567e-06	3.31711e-06	1	1	0
ZNF688	146542	broad.mit.edu	37	16	30582337	30582337	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:30582337G>C	ENST00000223459.6	-	2	1408	c.304C>G	c.(304-306)Cgg>Ggg	p.R102G	ZNF688_ENST00000395219.1_Missense_Mutation_p.R88G|ZNF688_ENST00000563707.1_Intron|ZNF688_ENST00000567855.1_Missense_Mutation_p.R102G	NM_145271.3	NP_660314.1	P0C7X2	ZN688_HUMAN	zinc finger protein 688	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(2)|lung(2)|ovary(1)	8						TCACCTCTCCGAGCTCCTCCC	0.597000													7	90					0	0	1	0	0
ZNF148	7707	broad.mit.edu	37	3	124951270	124951270	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:124951270G>A	ENST00000360647.4	-	9	2785	c.2300C>T	c.(2299-2301)tCa>tTa	p.S767L	ZNF148_ENST00000485866.1_Missense_Mutation_p.S767L|ZNF148_ENST00000544464.1_Missense_Mutation_p.S104L|ZNF148_ENST00000492394.1_Missense_Mutation_p.S767L|ZNF148_ENST00000497929.1_5'UTR|SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000484491.1_Missense_Mutation_p.S767L|ZNF148_ENST00000468369.1_Missense_Mutation_p.S117L	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	767					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding	p.S767L(1)		breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						GGGAAATTCTGAAAATTCAGC	0.433000													10	75					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207649591	207649591	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:207649591G>A	ENST00000367057.3	+	15	2918	c.2729G>A	c.(2728-2730)tGt>tAt	p.C910Y	CR2_ENST00000458541.2_Missense_Mutation_p.C824Y|CR2_ENST00000367059.3_Intron|CR2_ENST00000367058.3_Missense_Mutation_p.C851Y	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	851	Sushi 15.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TTCATAGGGTGTCCACCTCCG	0.493000													10	86					0	0	1	0	0
RBMXL1	494115	broad.mit.edu	37	1	89448344	89448344	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:89448344C>G	ENST00000399794.2	-	3	1881	c.1166G>C	c.(1165-1167)aGa>aCa	p.R389T	CCBL2_ENST00000370491.3_Intron|CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000260508.4_Intron|RBMXL1_ENST00000321792.5_Missense_Mutation_p.R389T|CCBL2_ENST00000446900.2_Intron	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	389							nucleotide binding|RNA binding										TTTCTAGTATCTGCTTCTGCC	0.448000													25	56					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48845627	48845627	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:48845627C>T	ENST00000314191.2	-	16	1785	c.1729G>A	c.(1729-1731)Gag>Aag	p.E577K	PRKDC_ENST00000338368.3_Missense_Mutation_p.E577K|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	577					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TCCAATTTCTCAACAATCTTC	0.308000								Non-homologous end-joining					4	27					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144886255	144886255	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:144886255C>T	ENST00000369359.4	-	26	3428	c.3390G>A	c.(3388-3390)ccG>ccA	p.P1130P	PDE4DIP_ENST00000530740.1_Silent_p.P1130P|PDE4DIP_ENST00000369354.3_Silent_p.P993P|PDE4DIP_ENST00000369356.4_Silent_p.P993P|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Silent_p.P1059P			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	993					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CCCCTCCCATCGGAGAAGGAG	0.488000			T	PDGFRB	MPD								18	431					0	0	1	0	0
ESF1	51575	broad.mit.edu	37	20	13763309	13763309	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:13763309C>G	ENST00000202816.1	-	2	585	c.478G>C	c.(478-480)Gaa>Caa	p.E160Q		NM_001276380.1|NM_016649.3	NP_001263309.1|NP_057733.2	Q9H501	ESF1_HUMAN	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	160	Lys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|nucleoplasm				endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(2)|skin(1)|stomach(1)	31						TGTGTAAATTCTTTGCTATCC	0.284000													8	46					0	0	1	0	0
SEMA3F	6405	broad.mit.edu	37	3	50220144	50220144	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:50220144C>T	ENST00000002829.3	+	9	1315	c.831C>T	c.(829-831)ttC>ttT	p.F277F	SEMA3F_ENST00000413852.1_Silent_p.F178F|SEMA3F_ENST00000434342.1_Silent_p.F246F	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	277	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		AGCTTTACTTCTTCTTCCGTG	0.627000													36	102					0	0	1	0	0
RRP36	88745	broad.mit.edu	37	6	42996920	42996920	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:42996920G>A	ENST00000244496.5	+	7	744	c.734G>A	c.(733-735)cGa>cAa	p.R245Q		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	245					ribosomal small subunit biogenesis|rRNA processing	nucleolus				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						AAGAGGCGACGAAATGCAGGC	0.502000													45	141					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160269029	160269029	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:160269029C>G	ENST00000241704.7	-	18	1922	c.1693G>C	c.(1693-1695)Gat>Cat	p.D565H	COPA_ENST00000368069.3_Missense_Mutation_p.D574H	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	565					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATGGGTAAATCCAGAGTTCGA	0.493000													13	103					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30673794	30673794	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:30673794G>C	ENST00000376406.3	-	10	3813	c.3166C>G	c.(3166-3168)Cag>Gag	p.Q1056E	MDC1_ENST00000376405.2_Missense_Mutation_p.Q792E|MDC1-AS1_ENST00000442150.1_RNA	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1056	Pro-rich.			Missing (in Ref. 2; CAH18685).	cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						TTCTGGCTCTGAGAGTTAAGG	0.537000								Other conserved DNA damage response genes					44	144					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102046919	102046919	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:102046919C>G	ENST00000549145.1	+	17	1724	c.1624C>G	c.(1624-1626)Ctt>Gtt	p.L542V	MYBPC1_ENST00000361466.2_Missense_Mutation_p.L554V|MYBPC1_ENST00000361685.2_Missense_Mutation_p.L554V|MYBPC1_ENST00000536007.1_Missense_Mutation_p.L510V|MYBPC1_ENST00000553190.1_Missense_Mutation_p.L529V|MYBPC1_ENST00000392934.3_Missense_Mutation_p.L516V|MYBPC1_ENST00000360610.2_Missense_Mutation_p.L529V|MYBPC1_ENST00000441232.1_Missense_Mutation_p.L529V|RP11-755O11.2_ENST00000547027.1_RNA|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000452455.2_Missense_Mutation_p.L529V|MYBPC1_ENST00000547509.1_Missense_Mutation_p.L515V|MYBPC1_ENST00000551300.1_Missense_Mutation_p.L430V|MYBPC1_ENST00000541119.1_Missense_Mutation_p.L517V|MYBPC1_ENST00000550270.1_Missense_Mutation_p.L529V|MYBPC1_ENST00000547405.1_Missense_Mutation_p.L503V|MYBPC1_ENST00000545503.2_Missense_Mutation_p.L529V			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	529	Ig-like C2-type 5.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						CCTGGATGGTCTTGATGCTGA	0.448000													13	93					0	0	1	0	0
DFFB	1677	broad.mit.edu	37	1	3789064	3789064	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:3789064C>G	ENST00000378209.3	+	6	1033	c.710C>G	c.(709-711)tCa>tGa	p.S237*	DFFB_ENST00000338895.3_Nonsense_Mutation_p.S237*	NM_004402.2	NP_004393.1	O76075	DFFB_HUMAN	DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)	237					apoptotic chromosome condensation|DNA fragmentation involved in apoptotic nuclear change|intracellular signal transduction	cytosol|nucleoplasm	deoxyribonuclease activity|enzyme binding			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_cancers(23;2.05e-30)|all_epithelial(116;6.22e-21)|all_lung(118;2.65e-08)|Lung NSC(185;6.25e-06)|Breast(487;0.000659)|Renal(390;0.00121)|all_neural(13;0.0019)|Hepatocellular(190;0.00705)|Colorectal(325;0.0113)|all_hematologic(16;0.0194)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0548)|Medulloblastoma(700;0.211)		Epithelial(90;1.18e-39)|OV - Ovarian serous cystadenocarcinoma(86;7.28e-23)|GBM - Glioblastoma multiforme(42;2.95e-17)|Colorectal(212;1.23e-05)|COAD - Colon adenocarcinoma(227;5.94e-05)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00038)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		AGCTGCTTATCAAGACACTCC	0.502000													25	59					0	0	1	0	0
ACTR3B	57180	broad.mit.edu	37	7	152549306	152549306	+	Silent	SNP	C	C	T	rs146208789		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:152549306C>T	ENST00000256001.8	+	10	1181	c.1047C>T	c.(1045-1047)ctC>ctT	p.L349L	ACTR3B_ENST00000537264.1_Silent_p.L261L|ACTR3B_ENST00000397282.2_Silent_p.L261L|ACTR3B_ENST00000377776.3_Intron	NM_020445.5	NP_065178.1	Q9P1U1	ARP3B_HUMAN	ARP3 actin-related protein 3 homolog B (yeast)	349					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding			breast(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	13		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		GGCTGAGGCTCAGCGAGGAGC	0.617000													36	91					0	0	1	0	0
TBK1	29110	broad.mit.edu	37	12	64868016	64868016	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:64868016G>T	ENST00000331710.5	+	6	886	c.547G>T	c.(547-549)Gat>Tat	p.D183Y		NM_013254.3	NP_037386.1	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	183	Protein kinase.				I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)	20				GBM - Glioblastoma multiforme(28;0.0386)		TTAGCACCCTGATATGTATGA	0.333000													22	74					6.21321e-17	6.8752e-17	1	1	0
MACC1	346389	broad.mit.edu	37	7	20198585	20198585	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:20198585G>A	ENST00000400331.5	-	5	1707	c.1399C>T	c.(1399-1401)Cat>Tat	p.H467Y	MACC1_ENST00000589011.1_Missense_Mutation_p.H467Y|MACC1_ENST00000332878.4_Missense_Mutation_p.H467Y	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	467					positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						AATTGTTGATGAACTACTTCA	0.358000													13	48					0	0	1	0	0
SEC23A	10484	broad.mit.edu	37	14	39524487	39524487	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:39524487G>C	ENST00000537403.1	-	10	2115	c.913C>G	c.(913-915)Caa>Gaa	p.Q305E	SEC23A_ENST00000307712.6_Missense_Mutation_p.Q507E|SEC23A_ENST00000545328.2_Missense_Mutation_p.Q478E|SEC23A_ENST00000536508.1_Missense_Mutation_p.Q381E			Q15436	SC23A_HUMAN	Sec23 homolog A (S. cerevisiae)	507					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|Golgi membrane|smooth endoplasmic reticulum membrane	protein binding|zinc ion binding			kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(4)|pancreas(1)|upper_aerodigestive_tract(1)	23	Hepatocellular(127;0.213)		Lung(238;0.00047)|LUAD - Lung adenocarcinoma(48;0.000565)	GBM - Glioblastoma multiforme(112;0.0151)		ATTTGAGTTTGAGCATCTGCC	0.393000													22	104					0	0	1	0	0
DCBLD1	285761	broad.mit.edu	37	6	117861837	117861837	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:117861837C>T	ENST00000338728.5	+	10	1228	c.1108C>T	c.(1108-1110)Cag>Tag	p.Q370*	GOPC_ENST00000467125.1_Intron|DCBLD1_ENST00000368503.4_Intron|DCBLD1_ENST00000296955.8_Nonsense_Mutation_p.Q370*|DCBLD1_ENST00000534777.1_3'UTR			Q8N8Z6	DCBD1_HUMAN	discoidin, CUB and LCCL domain containing 1	370	F5/8 type C.				cell adhesion	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_cancers(87;0.171)		GBM - Glioblastoma multiforme(226;0.0447)|OV - Ovarian serous cystadenocarcinoma(136;0.0921)|all cancers(137;0.125)		ATAGGTGTTTCAGGGTAACTC	0.428000													34	67					0	0	1	0	0
TMEM2	23670	broad.mit.edu	37	9	74332886	74332886	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:74332886C>G	ENST00000377044.4	-	13	2916	c.2377G>C	c.(2377-2379)Gat>Cat	p.D793H	TMEM2_ENST00000377066.5_Missense_Mutation_p.D730H	NM_001135820.1|NM_013390.2	NP_001129292.1|NP_037522.1	Q9UHN6	TMEM2_HUMAN	transmembrane protein 2	793						integral to membrane				central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(15)|liver(1)|lung(19)|ovary(2)|prostate(5)|skin(1)|stomach(1)|urinary_tract(2)	56		all_epithelial(88;4.56e-14)|Myeloproliferative disorder(762;0.0255)		GBM - Glioblastoma multiforme(74;7.45e-21)|OV - Ovarian serous cystadenocarcinoma(323;1.02e-16)		ACGATAATATCTCCTCCTCTG	0.368000													37	87					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179440946	179440946	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:179440946C>G	ENST00000589042.1	-	326	70137	c.69913G>C	c.(69913-69915)Gat>Cat	p.D23305H	TTN-AS1_ENST00000586452.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.D20737H|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D14240H|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D14432H|TTN_ENST00000359218.5_Missense_Mutation_p.D14365H|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D21664H	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	21664	Fibronectin type-III 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCTGAAGATCAGGAACAACG	0.463000													24	83					0	0	1	0	0
ARHGEF26	26084	broad.mit.edu	37	3	153839996	153839996	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:153839996C>T	ENST00000356448.4	+	2	499	c.215C>T	c.(214-216)tCg>tTg	p.S72L	ARHGEF26_ENST00000465817.1_Missense_Mutation_p.S72L|ARHGEF26_ENST00000465093.1_Missense_Mutation_p.S72L	NM_001251962.1	NP_001238891.1	Q96DR7	ARHGQ_HUMAN	Rho guanine nucleotide exchange factor (GEF) 26	72					regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	23						CCCACCGCCTCGGACAGCAGG	0.662000													3	17					0	0	1	0	0
UBE4B	10277	broad.mit.edu	37	1	10195123	10195123	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:10195123C>G	ENST00000377157.3	+	15	2429	c.1368C>G	c.(1366-1368)atC>atG	p.I456M	UBE4B_ENST00000343090.6_Missense_Mutation_p.I701M|UBE4B_ENST00000253251.8_Missense_Mutation_p.I572M	NM_006048.4	NP_006039.2	O95155	UBE4B_HUMAN	ubiquitination factor E4B	701					apoptosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to UV	cytoplasm|ubiquitin ligase complex	enzyme binding			NS(3)|breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(14)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	48		all_lung(284;1.13e-05)|Lung NSC(185;1.74e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0268)|Colorectal(212;1.42e-07)|COAD - Colon adenocarcinoma(227;2.77e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000435)|Kidney(185;0.000482)|KIRC - Kidney renal clear cell carcinoma(229;0.00164)|STAD - Stomach adenocarcinoma(132;0.0117)|READ - Rectum adenocarcinoma(331;0.046)		GTACAAAAATCAAGTTAGAAA	0.393000													15	55					0	0	1	0	0
IMPA2	3613	broad.mit.edu	37	18	12009892	12009892	+	Nonsense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:12009892G>T	ENST00000269159.3	+	3	483	c.241G>T	c.(241-243)Gaa>Taa	p.E81*	IMPA2_ENST00000588927.1_5'UTR|IMPA2_ENST00000588752.1_3'UTR|IMPA2_ENST00000589238.1_5'UTR	NM_014214.2	NP_055029.1	O14732	IMPA2_HUMAN	inositol(myo)-1(or 4)-monophosphatase 2	81					inositol phosphate dephosphorylation|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(1)|skin(2)|stomach(2)|urinary_tract(1)	12					Lithium(DB01356)	GTTCATTGCAGAAGAGGCCGC	0.537000													28	257					5.91797e-21	6.66e-21	1	1	0
TRMT1	55621	broad.mit.edu	37	19	13216140	13216140	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:13216140C>T	ENST00000592062.1	-	17	2344	c.1774G>A	c.(1774-1776)Gaa>Aaa	p.E592K	TRMT1_ENST00000437766.1_Missense_Mutation_p.E592K|TRMT1_ENST00000357720.4_Missense_Mutation_p.E592K|TRMT1_ENST00000221504.8_Missense_Mutation_p.E563K			Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)	592							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		GCCACATCTTCCGGCGGCTCC	0.622000											OREG0025289	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	131					0	0	1	0	0
IRX2	153572	broad.mit.edu	37	5	2749510	2749510	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:2749510G>A	ENST00000382611.6	-	2	889	c.641C>T	c.(640-642)tCg>tTg	p.S214L	IRX2_ENST00000302057.5_Missense_Mutation_p.S214L|IRX2_ENST00000502957.1_5'UTR	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	214						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		GTCCTCTGCCGAGGTCTCCGT	0.677000													5	65					0	0	1	0	0
FANCF	2188	broad.mit.edu	37	11	22647099	22647099	+	Missense_Mutation	SNP	G	G	C	rs146352365		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:22647099G>C	ENST00000428556.2	+	1	240	c.43G>C	c.(43-45)Gag>Cag	p.E15Q	FANCF_ENST00000327470.3_Silent_p.L86L																							CACAGTGACCGAGGGCCTGGA	0.662000											OREG0020844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	26	135					0	0	1	0	0
F5	2153	broad.mit.edu	37	1	169510493	169510493	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:169510493C>T	ENST00000367796.3	-	13	4051	c.3850G>A	c.(3850-3852)Gac>Aac	p.D1284N	F5_ENST00000367797.3_Missense_Mutation_p.D1279N			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1279	35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TGGCTGAGGTCTGGAGAAAGG	0.498000													73	367					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115612709	115612709	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:115612709G>C	ENST00000361384.2	-	1	1150	c.233C>G	c.(232-234)tCt>tGt	p.S78C	DCLRE1A_ENST00000369305.1_Missense_Mutation_p.S78C	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	78	Nuclear localization region.				cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		ATTCTGACTAGAAGCAACAGA	0.448000								Other identified genes with known or suspected DNA repair function					64	218					0	0	1	0	0
ZC3H7A	29066	broad.mit.edu	37	16	11855764	11855764	+	Splice_Site	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:11855764A>G	ENST00000396516.2	-	17	2411		c.e17+1		ZC3H7A_ENST00000355758.4_Splice_Site			Q8IWR0	Z3H7A_HUMAN	zinc finger CCCH-type containing 7A							nucleus	nucleic acid binding|zinc ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(2)|liver(1)|lung(3)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(2)	25						CACAATACTTACGAATGCCTT	0.348000													18	84					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													4	77					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15726098	15726098	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:15726098G>C	ENST00000378076.3	-	4	826	c.473C>G	c.(472-474)aCt>aGt	p.T158S		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	158					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CGGTTTAAGAGTTCTCCAGTG	0.408000													19	80					0	0	1	0	0
EFS	10278	broad.mit.edu	37	14	23828978	23828978	+	Missense_Mutation	SNP	C	C	T	rs115218741	byFrequency	TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:23828978C>T	ENST00000216733.3	-	4	1316	c.709G>A	c.(709-711)Gag>Aag	p.E237K	EFS_ENST00000429593.2_Intron|EFS_ENST00000351354.3_Missense_Mutation_p.E144K	NM_005864.2	NP_005855.1	O43281	EFS_HUMAN	embryonal Fyn-associated substrate	237	Pro-rich.				cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			endometrium(2)|kidney(1)|large_intestine(1)|liver(1)|lung(5)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)	16	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		AGCAGTTCCTCGGGTGCTTCA	0.647000													47	163					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14306661	14306661	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:14306661C>T	ENST00000378053.3	-	2	1748	c.1492G>A	c.(1492-1494)Gag>Aag	p.E498K	FLRT3_ENST00000341420.4_Missense_Mutation_p.E498K|MACROD2_ENST00000217246.4_Intron|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	498	Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GTTTCAGTCTCAATACAAACA	0.458000													26	111					0	0	1	0	0
DIO3OS	64150	broad.mit.edu	37	14	102026643	102026643	+	RNA	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:102026643G>A	ENST00000408206.1	-	0	116					NR_031649.1																						CGGGGTCCGCGAAGGTGGCTC	0.701000													6	15					0	0	1	0	0
KANK1	23189	broad.mit.edu	37	9	713094	713094	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:713094G>A	ENST00000382303.1	+	7	2980	c.2328G>A	c.(2326-2328)atG>atA	p.M776I	KANK1_ENST00000382297.2_Missense_Mutation_p.M776I|KANK1_ENST00000489369.1_3'UTR|KANK1_ENST00000382293.3_Missense_Mutation_p.M618I	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	776					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		GTCTCAAAATGAGGACTATAG	0.527000													24	151					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128340002	128340002	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:128340002G>C	ENST00000389524.4	+	12	1377	c.1324G>C	c.(1324-1326)Gaa>Caa	p.E442Q	MYO7B_ENST00000428314.1_Missense_Mutation_p.E442Q|MYO7B_ENST00000409816.2_Missense_Mutation_p.E442Q			Q6PIF6	MYO7B_HUMAN	myosin VIIB	442	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ATTTGGCTTTGAAAATTTCGA	0.507000													10	21					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129753970	129753970	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:129753970G>C	ENST00000446488.3	-	7	914	c.811C>G	c.(811-813)Cag>Gag	p.Q271E	NFRKB_ENST00000524794.1_Missense_Mutation_p.Q296E|NFRKB_ENST00000304521.5_Missense_Mutation_p.Q271E|NFRKB_ENST00000524746.1_Missense_Mutation_p.Q271E	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	271					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		CTTACTGGCTGATGTTTCCGC	0.498000													67	148					0	0	1	0	0
METAP1D	254042	broad.mit.edu	37	2	172926242	172926242	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:172926242C>T	ENST00000315796.4	+	2	444	c.57C>T	c.(55-57)ttC>ttT	p.F19F		NM_199227.1	NP_954697.1	Q6UB28	AMP1D_HUMAN	methionyl aminopeptidase type 1D (mitochondrial)	19					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			NS(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	8						ATAGAATTTTCTCTTCACCAC	0.343000													44	214					0	0	1	0	0
GIGYF1	64599	broad.mit.edu	37	7	100283903	100283903	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:100283903C>T	ENST00000275732.5	-	8	2057	c.848G>A	c.(847-849)gGc>gAc	p.G283D	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	283										central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CTCCTCAAAGCCTTCAGGCGC	0.602000													14	121					0	0	1	0	0
LOC100131347	100131347	broad.mit.edu	37	17	37213308	37213308	+	RNA	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:37213308G>A	ENST00000583447.1	+	0	37					NR_036551.1																						CAGGCTCAGCGAAGGGAGGCT	0.622000													3	22					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35384207	35384207	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:35384207C>T	ENST00000426836.1	-	9	1123	c.751G>A	c.(751-753)Gag>Aag	p.E251K	DSN1_ENST00000373734.4_Missense_Mutation_p.E144K|DSN1_ENST00000373745.3_Missense_Mutation_p.E251K|DSN1_ENST00000373750.4_Missense_Mutation_p.E251K|DSN1_ENST00000373740.3_Missense_Mutation_p.E179K|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000448110.1_Missense_Mutation_p.E235K	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	251					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				ACTTTGACCTCAGTAATTTTG	0.348000													28	102					0	0	1	0	0
CCNB3	85417	broad.mit.edu	37	X	50054322	50054322	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:50054322C>G	ENST00000376042.1	+	6	3451	c.3153C>G	c.(3151-3153)ccC>ccG	p.P1051P	CCNB3_ENST00000276014.7_Silent_p.P1051P|CCNB3_ENST00000348603.2_Intron|CCNB3_ENST00000376038.1_Intron			Q8WWL7	CCNB3_HUMAN	cyclin B3	1051					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding	p.P1051P(2)		breast(3)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(41)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Ovarian(276;0.236)					TCTTGATCCCCCAAATTGGAA	0.512000													29	42					0	0	1	0	0
GATA2	2624	broad.mit.edu	37	3	128199879	128199879	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:128199879C>T	ENST00000341105.2	-	6	1757	c.1426G>A	c.(1426-1428)Gtg>Atg	p.V476M	GATA2_ENST00000489987.1_5'UTR|GATA2_ENST00000487848.1_Missense_Mutation_p.V476M|GATA2_ENST00000430265.2_Missense_Mutation_p.V462M	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	476					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		ATGGCGGTCACCATGCTGGAC	0.672000			Mis		AML(CML blast transformation)								17	30					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248020584	248020584	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:248020584G>A	ENST00000366481.3	+	1	84	c.36G>A	c.(34-36)gaG>gaA	p.E12E		NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	12						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCTGCGCGAGGATGCGCGGT	0.731000													4	12					0	0	1	0	0
ZNF324	25799	broad.mit.edu	37	19	58983039	58983039	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:58983039G>A	ENST00000536459.2	+	4	1889	c.1180G>A	c.(1180-1182)Gag>Aag	p.E394K	ZNF324_ENST00000535298.1_Missense_Mutation_p.E171K|ZNF324_ENST00000196482.3_Missense_Mutation_p.E394K			O75467	Z324A_HUMAN	zinc finger protein 324	394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(2)|prostate(2)|urinary_tract(2)	16		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		GCACACAGGCGAGAAGCCCTT	0.652000													19	82					0	0	1	0	0
TRIM62	55223	broad.mit.edu	37	1	33613131	33613131	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:33613131C>G	ENST00000291416.5	-	5	1308	c.1075G>C	c.(1075-1077)Gag>Cag	p.E359Q	TRIM62_ENST00000543586.1_Missense_Mutation_p.E238Q	NM_018207.2	NP_060677.2	Q9BVG3	TRI62_HUMAN	tripartite motif containing 62	359	B30.2/SPRY.					intracellular	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)				TGGGTCTTCTCCGCCACCACC	0.627000													12	82					0	0	1	0	0
PLBD2	196463	broad.mit.edu	37	12	113812658	113812658	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:113812658C>G	ENST00000280800.3	+	5	736	c.705C>G	c.(703-705)atC>atG	p.I235M	PLBD2_ENST00000545182.2_Missense_Mutation_p.I235M	NM_173542.3	NP_775813.2	Q8NHP8	PLBL2_HUMAN	phospholipase B domain containing 2	235					lipid catabolic process	lysosomal lumen	hydrolase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(7)|prostate(1)	13						AGACCAAGATCAAACCTTCTC	0.602000													14	83					0	0	1	0	0
LMBRD2	92255	broad.mit.edu	37	5	36105264	36105264	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:36105264C>G	ENST00000296603.4	-	17	2395	c.1933G>C	c.(1933-1935)Gaa>Caa	p.E645Q		NM_001007527.1	NP_001007528.1	Q68DH5	LMBD2_HUMAN	LMBR1 domain containing 2	645						integral to membrane				breast(2)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(31;0.000146)		Epithelial(62;0.0396)|Lung(74;0.111)|all cancers(62;0.115)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGGTCCCTTTCAGTCCTGTTA	0.408000													27	156					0	0	1	0	0
DZIP1L	199221	broad.mit.edu	37	3	137822729	137822729	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:137822729G>A	ENST00000327532.2	-	2	447	c.85C>T	c.(85-87)Cgc>Tgc	p.R29C	DZIP1L_ENST00000469243.1_Missense_Mutation_p.R29C	NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	29						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						CTATCATGGCGAGGCTGAAAC	0.602000													59	257					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	104778759	104778759	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:104778759C>T	ENST00000406091.3	+	3	692	c.692C>T	c.(691-693)tCa>tTa	p.S231L		NM_001100117.2	NP_001093587.1	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	262					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GACATAGCTTCAGACAGGTAA	0.383000										HNSCC(12;0.0054)			14	37					0	0	1	0	0
RBBP6	5930	broad.mit.edu	37	16	24551983	24551983	+	Silent	SNP	C	C	T	rs141709663	byFrequency	TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:24551983C>T	ENST00000319715.4	+	1	468	c.36C>T	c.(34-36)ctC>ctT	p.L12L	RBBP6_ENST00000452655.2_Silent_p.L12L|RBBP6_ENST00000381039.3_Silent_p.L12L|RBBP6_ENST00000348022.2_Silent_p.L12L	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	12	DWNN.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		CCTCTAAACTCAACTATGATA	0.458000													24	96					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43414795	43414795	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:43414795C>G	ENST00000187910.2	-	3	708	c.643G>C	c.(643-645)Gaa>Caa	p.E215Q	PSG6_ENST00000292125.2_Missense_Mutation_p.E215Q|PSG6_ENST00000402603.4_Missense_Mutation_p.E215Q	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				ATTTCACATTCATAGGGTCCT	0.507000													116	363					0	0	1	0	0
FEZ1	9638	broad.mit.edu	37	11	125351490	125351490	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:125351490G>C	ENST00000278919.3	-	3	585	c.351C>G	c.(349-351)ctC>ctG	p.L117L	FEZ1_ENST00000527350.1_5'UTR	NM_005103.4	NP_005094.1	Q99689	FEZ1_HUMAN	fasciculation and elongation protein zeta 1 (zygin I)	117					axon guidance|cell adhesion|transport	microtubule|plasma membrane				breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	24	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0934)		AGTCTTCTGAGAGTGAAGGGA	0.532000													56	135					0	0	1	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103086512	103086512	+	Silent	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:103086512A>G	ENST00000375735.2	+	55	8901	c.8757A>G	c.(8755-8757)ggA>ggG	p.G2919G	DYNC2H1_ENST00000334267.7_Intron|DYNC2H1_ENST00000398093.3_Silent_p.G2919G	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	2919	Stalk (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GAAAAGCTGGAGAACAAAGTG	0.358000													5	19					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2974522	2974522	+	Splice_Site	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:2974522G>A	ENST00000342628.2	-	6	1132	c.1020_splice	c.e6+1	p.S340_splice	FOXM1_ENST00000359843.3_Splice_Site_p.S340_splice|FOXM1_ENST00000537018.1_5'UTR|FOXM1_ENST00000361953.3_Intron	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	340					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GAACCTTACTGATTCCAAGTG	0.542000													24	98					0	0	1	0	0
ZFP42	132625	broad.mit.edu	37	4	188924781	188924781	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:188924781C>T	ENST00000326866.4	+	4	1228	c.820C>T	c.(820-822)Cgt>Tgt	p.R274C	ZFP42_ENST00000509524.1_Missense_Mutation_p.R274C	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	274					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		GGGGGAGAAACGTTTCGTGTG	0.488000													4	125					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178552074	178552074	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:178552074G>A	ENST00000251582.7	-	19	2959	c.2858C>T	c.(2857-2859)tCc>tTc	p.S953F		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	953	TSP type-1 3.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding	p.S953F(1)		breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GGCGTGCACGGAGCGGGTGGT	0.697000													42	276					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35166146	35166146	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:35166146C>A	ENST00000156471.5	-	30	3705	c.3480G>T	c.(3478-3480)gtG>gtT	p.V1160V		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	1160						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		GCAAGAGCTGCACATGGGGTA	0.418000													33	43					1.56442e-22	1.76604e-22	1	1	0
RUNX1	861	broad.mit.edu	37	21	36265261	36265261	+	Splice_Site	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr21:36265261C>T	ENST00000300305.3	-	2	503		c.e2-1		RUNX1_ENST00000437180.1_Splice_Site|RUNX1_ENST00000486278.2_Splice_Site			Q01196	RUNX1_HUMAN	runt-related transcription factor 1						myeloid cell differentiation|negative regulation of granulocyte differentiation|positive regulation of angiogenesis|positive regulation of granulocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|calcium ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			breast(5)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(428)|large_intestine(3)|lung(6)|oesophagus(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	452						AGTATGCATTCTGAAATAACA	0.299000			T	"""RPL22, MDS1, EVI1, CBFA2T3, CBFA2T1, ETV6, LAF4"""	"""AML, preB- ALL, T-ALL"""								13	37					0	0	1	0	0
PTPMT1	114971	broad.mit.edu	37	11	47587364	47587364	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:47587364G>C	ENST00000534775.1	+	1	355	c.190G>C	c.(190-192)Gag>Cag	p.E64Q	PTPMT1_ENST00000326656.8_Intron|PTPMT1_ENST00000426530.2_Missense_Mutation_p.E64Q|NDUFS3_ENST00000533507.1_Intron|PTPMT1_ENST00000326674.9_Intron			Q8WUK0	PTPM1_HUMAN	protein tyrosine phosphatase, mitochondrial 1	0					inositol phosphate dephosphorylation	mitochondrial inner membrane	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	6						CCGGGCCGGGGAGCCCGGGCC	0.746000													3	15					0	0	1	0	0
CWC22	57703	broad.mit.edu	37	2	180810028	180810028	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:180810028G>C	ENST00000410053.3	-	20	2854	c.2555C>G	c.(2554-2556)tCa>tGa	p.S852*	CWC22_ENST00000295749.6_Nonsense_Mutation_p.S852*	NM_020943.2	NP_065994.1	Q9HCG8	CWC22_HUMAN	CWC22 spliceosome-associated protein homolog (S. cerevisiae)	852						catalytic step 2 spliceosome	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(8)|stomach(1)	30						CTTTGACTTTGATCTATCTTT	0.363000													19	88					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4429522	4429522	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:4429522G>C	ENST00000301280.5	+	9	1793	c.1692G>C	c.(1690-1692)gaG>gaC	p.E564D		NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	564					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTTCTGTGAGAACCACCGGC	0.602000								Chromatin Structure					15	126					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48703596	48703596	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:48703596G>C	ENST00000352832.5	+	34	6609	c.6237G>C	c.(6235-6237)aaG>aaC	p.K2079N	CACNA1G_ENST00000502264.1_Missense_Mutation_p.K2135N|CACNA1G_ENST00000510115.1_Missense_Mutation_p.K2127N|CACNA1G_ENST00000359106.5_Missense_Mutation_p.K2206N|CACNA1G_ENST00000515765.1_Missense_Mutation_p.K2150N|CACNA1G_ENST00000354983.4_Missense_Mutation_p.K2172N|CACNA1G_ENST00000360761.4_Missense_Mutation_p.K2090N|CACNA1G_ENST00000514717.1_Missense_Mutation_p.K2056N|CACNA1G_ENST00000442258.2_Missense_Mutation_p.K2072N|CACNA1G_ENST00000515411.1_Missense_Mutation_p.K2143N|CACNA1G_ENST00000515165.1_Missense_Mutation_p.K2113N|CACNA1G_ENST00000507609.1_Missense_Mutation_p.K2106N|CACNA1G_ENST00000358244.5_Intron|CACNA1G_ENST00000507510.2_Missense_Mutation_p.K2161N|CACNA1G_ENST00000513689.2_Missense_Mutation_p.K2116N|CACNA1G_ENST00000507336.1_Missense_Mutation_p.K2195N|CACNA1G_ENST00000514079.1_Missense_Mutation_p.K2120N|CACNA1G_ENST00000507896.1_Intron|CACNA1G_ENST00000505165.1_Intron|CACNA1G_ENST00000429973.2_Missense_Mutation_p.K2095N|CACNA1G_ENST00000510366.1_Missense_Mutation_p.K2061N|CACNA1G_ENST00000503485.1_Missense_Mutation_p.K2079N|CACNA1G_ENST00000513964.1_Missense_Mutation_p.K2068N|CACNA1G_ENST00000512389.1_Missense_Mutation_p.K2102N|CACNA1G_ENST00000514181.1_Missense_Mutation_p.K2088N	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	2206					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	ACTGGGGCAAGGGCCCTCCAG	0.647000											OREG0024569	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	115					0	0	1	0	0
HTRA4	203100	broad.mit.edu	37	8	38832189	38832189	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:38832189C>T	ENST00000302495.4	+	1	507	c.407C>T	c.(406-408)gCg>gTg	p.A136V		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	136	Kazal-like.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			AACCGCGCCGCGCGCCGCCTG	0.731000													4	6					0	0	1	0	0
KRT19	3880	broad.mit.edu	37	17	39684413	39684413	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:39684413G>A	ENST00000361566.3	-	1	147	c.87C>T	c.(85-87)gtC>gtT	p.V29V		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				CGCGAAAGGCGACCCCCGGCC	0.716000													5	20					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64564707	64564707	+	Missense_Mutation	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:64564707A>G	ENST00000357395.3	+	63	12448	c.1304A>G	c.(1303-1305)aAc>aGc	p.N435S	SYNE2_ENST00000554584.1_Missense_Mutation_p.N4083S|SYNE2_ENST00000344113.4_Missense_Mutation_p.N4050S|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000358025.3_Missense_Mutation_p.N4050S|SYNE2_ENST00000394768.2_Missense_Mutation_p.N435S|SYNE2_ENST00000555002.1_Missense_Mutation_p.N684S			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4050					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTGAGTTTGAACCAGAGAAAA	0.463000													51	106					0	0	1	0	0
ASCC2	84164	broad.mit.edu	37	22	30218359	30218359	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:30218359C>T	ENST00000397771.2	-	6	683	c.506G>A	c.(505-507)gGa>gAa	p.G169E	ASCC2_ENST00000542393.1_Missense_Mutation_p.G93E|ASCC2_ENST00000307790.3_Missense_Mutation_p.G169E			Q9H1I8	ASCC2_HUMAN	activating signal cointegrator 1 complex subunit 2	169					regulation of transcription, DNA-dependent|transcription, DNA-dependent					endometrium(3)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(5;0.000103)|Epithelial(10;0.0169)|all cancers(5;0.0259)			GTTGCCTTTTCCAAAGAGCAC	0.488000													50	168					0	0	1	0	0
C11orf84	144097	broad.mit.edu	37	11	63585732	63585732	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:63585732G>A	ENST00000294244.4	+	3	801	c.502G>A	c.(502-504)Gct>Act	p.A168T		NM_138471.1	NP_612480.1	Q9BUA3	CK084_HUMAN	chromosome 11 open reading frame 84	168	Pro-rich.									endometrium(3)|kidney(1)|lung(3)|skin(1)	8						CAACCCAGACGCTGCCAGAAT	0.612000													93	102					0	0	1	0	0
DDB2	1643	broad.mit.edu	37	11	47256828	47256828	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:47256828C>T	ENST00000378601.3	+	6	905	c.710C>T	c.(709-711)tCa>tTa	p.S237L	DDB2_ENST00000378603.3_Silent_p.F232F|DDB2_ENST00000256996.4_Silent_p.F296F|DDB2_ENST00000378600.3_Intron			Q92466	DDB2_HUMAN	damage-specific DNA binding protein 2, 48kDa	237					nucleotide-excision repair, DNA damage removal|protein autoubiquitination|protein polyubiquitination|response to UV	nucleoplasm|protein complex	damaged DNA binding|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|skin(1)	17						CAGCTTGTTTCAGTCCCGATG	0.617000			"""Mis, N"""			"""skin basal cell, skin squamous cell, melanoma"""		Direct reversal of damage;Nucleotide excision repair (NER)	Xeroderma Pigmentosum				33	179					0	0	1	0	0
RNF157	114804	broad.mit.edu	37	17	74158662	74158662	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:74158662C>T	ENST00000269391.6	-	9	895	c.763G>A	c.(763-765)Gaa>Aaa	p.E255K	RNF157_ENST00000319945.6_Missense_Mutation_p.E255K	NM_052916.2	NP_443148.1	Q96PX1	RN157_HUMAN	ring finger protein 157	255							zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	25			LUSC - Lung squamous cell carcinoma(166;0.187)			TACTTGTTTTCAATTCCATAG	0.448000													20	66					0	0	1	0	0
GAS8	2622	broad.mit.edu	37	16	90108891	90108891	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:90108891C>G	ENST00000268699.4	+	10	1357	c.1235C>G	c.(1234-1236)tCg>tGg	p.S412W	GAS8_ENST00000536122.1_Missense_Mutation_p.S387W|URAHP_ENST00000409873.1_Intron	NM_001481.2	NP_001472.1	O95995	GAS8_HUMAN	growth arrest-specific 8	412					negative regulation of cell proliferation|sperm motility	cilium|Golgi apparatus|microtubule|microtubule basal body|microtubule-based flagellum	protein binding			endometrium(3)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	14		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.029)		GTTCTTGAGTCGAAGAACAGC	0.607000													19	38					0	0	1	0	0
LSR	51599	broad.mit.edu	37	19	35752837	35752837	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:35752837C>G	ENST00000361790.3	+	4	887	c.728C>G	c.(727-729)tCa>tGa	p.S243*	LSR_ENST00000597933.1_3'UTR|LSR_ENST00000360798.3_Intron|LSR_ENST00000354900.3_Intron|LSR_ENST00000427250.1_Intron|LSR_ENST00000347609.4_Nonsense_Mutation_p.S206*|LSR_ENST00000602122.1_Intron	NM_205834.3	NP_991403.1	Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	243					embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GGGAGGACCTCAGGGGTGGCT	0.612000													30	75					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135203294	135203294	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:135203294C>T	ENST00000372169.2	-	10	3873	c.3691G>A	c.(3691-3693)Gaa>Aaa	p.E1231K	SETX_ENST00000224140.5_Missense_Mutation_p.E1231K|SETX_ENST00000393220.1_Missense_Mutation_p.E1231K			Q7Z333	SETX_HUMAN	senataxin	1231					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		CTGATGGGTTCTGTACAAGTA	0.368000													24	162					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95775921	95775921	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:95775921G>A	ENST00000416240.2	-	14	1592	c.1402C>T	c.(1402-1404)Cga>Tga	p.R468*	SLC25A13_ENST00000542654.1_Nonsense_Mutation_p.R359*|SLC25A13_ENST00000265631.5_Nonsense_Mutation_p.R467*	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	467					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	GCACTGACTCGAGGACCAGTG	0.418000													53	290					0	0	1	0	0
GCSHP3	100329109	broad.mit.edu	37	2	206980863	206980863	+	RNA	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:206980863C>T	ENST00000453039.1	+	0	593					NR_033248.1																						ATGTATTTCTCATATGCTTCT	0.363000													10	126					0	0	1	0	0
ASIC3	9311	broad.mit.edu	37	7	150748969	150748969	+	Silent	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:150748969T>C	ENST00000357922.4	+	7	1881	c.1287T>C	c.(1285-1287)taT>taC	p.Y429Y	ASIC3_ENST00000349064.5_Silent_p.Y429Y|ASIC3_ENST00000297512.8_Silent_p.Y429Y	NM_020322.3	NP_064718.1	Q9UHC3	ACCN3_HUMAN	acid-sensing (proton-gated) ion channel 3	429					sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity										AGAAGGCCTATGAGATGTCAG	0.587000													5	106					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166904577	166904577	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:166904577G>T	ENST00000271417.3	-	6	896	c.841C>A	c.(841-843)Ccc>Acc	p.P281T	ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000525740.1_Intron|ILDR2_ENST00000529071.1_Missense_Mutation_p.P262T|ILDR2_ENST00000526687.1_Intron|ILDR2_ENST00000528703.1_Intron|ILDR2_ENST00000469934.2_Missense_Mutation_p.P281T	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	281						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						GGTGCCAAGGGAGGTGGATGC	0.607000													40	125					6.45866e-13	7.0186e-13	1	1	0
RTN4IP1	84816	broad.mit.edu	37	6	107070779	107070779	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:107070779C>G	ENST00000539449.1	-	2	816	c.340G>C	c.(340-342)Gaa>Caa	p.E114Q	RTN4IP1_ENST00000369063.3_Missense_Mutation_p.E114Q			Q8WWV3	RT4I1_HUMAN	reticulon 4 interacting protein 1	114						mitochondrion	oxidoreductase activity|zinc ion binding			breast(1)|kidney(3)|large_intestine(2)|lung(6)|urinary_tract(1)	13	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;9.45e-05)|Acute lymphoblastic leukemia(125;2.13e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.0144)	Epithelial(6;0.000873)|all cancers(7;0.00363)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0394)	all cancers(137;0.113)|BRCA - Breast invasive adenocarcinoma(108;0.127)|Epithelial(106;0.144)		AGAGGAAATTCTTCTCCTTTG	0.423000													20	34					0	0	1	0	0
HMGB1	3146	broad.mit.edu	37	13	31035512	31035512	+	Missense_Mutation	SNP	T	T	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:31035512T>A	ENST00000405805.1	-	5	1570	c.630A>T	c.(628-630)gaA>gaT	p.E210D	HMGB1_ENST00000399494.1_Missense_Mutation_p.E210D|HMGB1_ENST00000399489.1_3'UTR|HMGB1_ENST00000339872.4_Missense_Mutation_p.E210D|HMGB1_ENST00000341423.5_Missense_Mutation_p.E210D			P09429	HMGB1_HUMAN	high mobility group box 1	210	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(1)|ovary(1)	8		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		CATCAtcatcttcttcttcat	0.378000													3	31					0	0	1	0	0
DIO2	1734	broad.mit.edu	37	14	80669310	80669310	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:80669310C>A	ENST00000557010.1	-	4	929	c.544G>T	c.(544-546)Gtg>Ttg	p.V182L	DIO2_ENST00000438257.4_Missense_Mutation_p.V182L|DIO2_ENST00000422005.3_3'UTR|DIO2_ENST00000555750.1_Missense_Mutation_p.V218L|DIO2_ENST00000557125.1_Missense_Mutation_p.R56S	NM_000793.5|NM_001242502.1|NM_001242503.1	NP_000784.2|NP_001229431.1|NP_001229432.1	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II	182					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(14)|skin(1)|stomach(1)	25				BRCA - Breast invasive adenocarcinoma(234;0.0281)		TGCTTCTTCACCTCAAAAGAC	0.562000											OREG0022848	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	91					7.41945e-09	7.86289e-09	1	1	0
ZBTB38	253461	broad.mit.edu	37	3	141164465	141164465	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:141164465G>A	ENST00000514251.1	+	4	3514	c.3235G>A	c.(3235-3237)Gag>Aag	p.E1079K	ZBTB38_ENST00000441582.2_Missense_Mutation_p.E1079K|ZBTB38_ENST00000321464.5_Missense_Mutation_p.E1080K			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	1079					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						CACCTTGAATGAGACCCTCAA	0.433000													23	109					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222827592	222827592	+	Silent	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:222827592G>T	ENST00000344922.5	+	16	4354	c.4329G>T	c.(4327-4329)cgG>cgT	p.R1443R	MIA3_ENST00000344441.6_Silent_p.R1443R|MIA3_ENST00000340535.7_Silent_p.R321R|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1443				R -> Q (in Ref. 7; AAH47116).	exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		TAGGTGACCGGAATGAGAAGA	0.328000													23	89					2.27525e-19	2.54478e-19	1	1	0
PIGN	23556	broad.mit.edu	37	18	59763180	59763180	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:59763180G>A	ENST00000357637.5	-	23	2496	c.2081C>T	c.(2080-2082)tCt>tTt	p.S694F	PIGN_ENST00000400334.3_Missense_Mutation_p.S694F	NM_176787.4	NP_789744.1	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class N	694					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22		Colorectal(73;0.187)				AACCAAGGAAGAGGCTGCAAT	0.463000													14	25					0	0	1	0	0
HOXD3	3232	broad.mit.edu	37	2	177034197	177034197	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:177034197C>A	ENST00000468418.3	+	3	2445	c.355C>A	c.(355-357)Ccc>Acc	p.P119T	HOXD3_ENST00000249440.3_Missense_Mutation_p.P119T|HOXD3_ENST00000410016.1_Missense_Mutation_p.P119T			P31249	HXD3_HUMAN	homeobox D3	119	Poly-Pro.				anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		Gccaccacaaccccctcctcc	0.642000													15	58					0.000308642	0.000314261	1	1	0
B2M	567	broad.mit.edu	37	15	45007818	45007818	+	Nonsense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:45007818G>T	ENST00000558401.1	+	2	335	c.265G>T	c.(265-267)Gaa>Taa	p.E89*	B2M_ENST00000544417.1_Nonsense_Mutation_p.E89*|B2M_ENST00000559220.1_Intron|B2M_ENST00000559916.1_Nonsense_Mutation_p.E89*	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	89	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		GTACTACACTGAATTCACCCC	0.413000													51	71					1.07234e-20	1.20494e-20	1	1	0
CPA3	1359	broad.mit.edu	37	3	148601507	148601507	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:148601507G>A	ENST00000296046.3	+	9	938	c.886G>A	c.(886-888)Gaa>Aaa	p.E296K	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	296					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CCACCTGAATGAAATCAAGGT	0.443000													25	121					0	0	1	0	0
TDRD10	126668	broad.mit.edu	37	1	154480903	154480903	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:154480903C>G	ENST00000368482.4	+	4	925	c.87C>G	c.(85-87)ttC>ttG	p.F29L	TDRD10_ENST00000368480.3_Missense_Mutation_p.F29L	NM_001098475.1|NM_182499.3	NP_001091945.1|NP_872305.3	Q5VZ19	TDR10_HUMAN	tudor domain containing 10	29							nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	29	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			TCTTAGGATTCAAGAAAAGAG	0.408000													16	178					0	0	1	0	0
SLC39A3	29985	broad.mit.edu	37	19	2733109	2733109	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:2733109C>G	ENST00000269740.4	-	3	914	c.585G>C	c.(583-585)gaG>gaC	p.E195D	AC006538.4_ENST00000586572.1_Intron|SLC39A3_ENST00000545664.1_Missense_Mutation_p.E195D	NM_144564.4	NP_653165.2	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter), member 3	195						integral to membrane|plasma membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCACCACTTTCTCCCCCTCCT	0.716000													43	92					0	0	1	0	0
IL33	90865	broad.mit.edu	37	9	6252872	6252872	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:6252872C>T	ENST00000381434.3	+	4	363	c.350C>T	c.(349-351)tCa>tTa	p.S117L	IL33_ENST00000456383.2_Intron|IL33_ENST00000417746.2_Intron	NM_033439.3	NP_254274.1	O95760	IL33_HUMAN	interleukin 33	117					positive regulation of chemokine secretion|positive regulation of inflammatory response|positive regulation of macrophage activation|positive regulation of transcription from RNA polymerase II promoter	extracellular space	cytokine activity			breast(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|stomach(1)|urinary_tract(1)	16		Acute lymphoblastic leukemia(23;0.158)|Prostate(43;0.167)		GBM - Glioblastoma multiforme(50;0.0161)|Lung(218;0.105)		ACAGGAATTTCACCTATTACA	0.318000													17	70					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19360591	19360591	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:19360591G>A	ENST00000252575.5	+	15	3880	c.3837G>A	c.(3835-3837)cgG>cgA	p.R1279R	NCAN_ENST00000538881.1_Silent_p.R730R	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1279					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GTTCACATCGGATGCGGCGAc	0.592000													12	85					0	0	1	0	0
NUFIP1	26747	broad.mit.edu	37	13	45533522	45533522	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:45533522C>T	ENST00000379161.4	-	7	1061	c.1015G>A	c.(1015-1017)Gat>Aat	p.D339N		NM_012345.2	NP_036477.2	Q9UHK0	NUFP1_HUMAN	nuclear fragile X mental retardation protein interacting protein 1	339					box C/D snoRNP assembly|positive regulation of transcription from RNA polymerase II promoter|RNA processing	actin cytoskeleton|cytosolic ribosome|nuclear matrix|nucleolus|perichromatin fibrils|pre-snoRNP complex|presynaptic active zone|transcription elongation factor complex	DNA binding|identical protein binding|protein binding, bridging|RNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(4)|skin(3)	18		Lung NSC(96;8.23e-05)|Breast(139;0.00378)|Prostate(109;0.0107)|all_hematologic(4;0.014)|Lung SC(185;0.0262)|Hepatocellular(98;0.0524)|Acute lymphoblastic leukemia(4;0.143)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000306)|BRCA - Breast invasive adenocarcinoma(63;0.125)		TTACCAGAATCACTGTTTATC	0.398000													15	73					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53488668	53488668	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:53488668C>T	ENST00000262133.6	+	8	1230	c.1093C>T	c.(1093-1095)Ctc>Ttc	p.L365F	RBL2_ENST00000379935.4_3'UTR|RBL2_ENST00000544545.1_Missense_Mutation_p.L149F	NM_005611.3	NP_005602.3	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	365					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						AATTGGGACTCTCTCAAGGTG	0.433000													11	58					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	165947292	165947292	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:165947292C>T	ENST00000360093.3	-	28	5862	c.5371G>A	c.(5371-5373)Gag>Aag	p.E1791K	SCN3A_ENST00000283254.7_Missense_Mutation_p.E1791K|SCN3A_ENST00000409101.3_Missense_Mutation_p.E1742K|AC013463.2_ENST00000431341.1_RNA|SCN3A_ENST00000540861.1_Missense_Mutation_p.E274K	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1791						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	TAGAACATCTCAAAGTCATCC	0.473000													46	216					0	0	1	0	0
DCLRE1A	9937	broad.mit.edu	37	10	115603979	115603979	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:115603979G>A	ENST00000361384.2	-	5	3320	c.2403C>T	c.(2401-2403)ctC>ctT	p.L801L	DCLRE1A_ENST00000369305.1_Silent_p.L801L	NM_014881.3	NP_055696.3	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	801					cell division|mitosis	nucleus	hydrolase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(1)|skin(2)|urinary_tract(1)	31				Epithelial(162;0.0157)|all cancers(201;0.0171)		GAAGATAAAAGAGGATCATGA	0.428000								Other identified genes with known or suspected DNA repair function					22	57					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167096012	167096012	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:167096012G>C	ENST00000361200.2	+	6	1810	c.1644G>C	c.(1642-1644)aaG>aaC	p.K548N	DUSP27_ENST00000443333.1_Missense_Mutation_p.K548N|DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000271385.5_Missense_Mutation_p.K548N			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	548					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						AAAGATGGAAGATCAAGAGAA	0.547000													35	179					0	0	1	0	0
XRCC6	2547	broad.mit.edu	37	22	42059661	42059661	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:42059661G>C	ENST00000359308.4	+	12	2327	c.1672G>C	c.(1672-1674)Gag>Cag	p.E558Q	XRCC6_ENST00000428575.2_Missense_Mutation_p.E425Q|XRCC6_ENST00000360079.3_Missense_Mutation_p.E558Q|XRCC6_ENST00000405506.1_Missense_Mutation_p.E508Q|XRCC6_ENST00000405878.1_Missense_Mutation_p.E558Q|XRCC6_ENST00000402580.3_Missense_Mutation_p.E517Q			P12956	XRCC6_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 6	558					DNA ligation|double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|provirus integration|telomere maintenance|transcription, DNA-dependent	DNA-dependent protein kinase-DNA ligase 4 complex|Ku70:Ku80 complex|membrane fraction|nuclear telomere cap complex|transcription factor complex	5'-deoxyribose-5-phosphate lyase activity|ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	31						GCCCAAGGTGGAGTATTCAGA	0.532000								Non-homologous end-joining					52	105					0	0	1	0	0
PDE6C	5146	broad.mit.edu	37	10	95400215	95400215	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:95400215C>G	ENST00000371447.3	+	13	1776	c.1638C>G	c.(1636-1638)acC>acG	p.T546T		NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	546					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				AGGTTCTTACCAGATGGATGT	0.433000													42	134					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50776712	50776712	+	Missense_Mutation	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:50776712T>C	ENST00000216923.4	-	5	1062	c.713A>G	c.(712-714)tAc>tGc	p.Y238C	ZFP64_ENST00000371518.2_Missense_Mutation_p.Y238C|ZFP64_ENST00000346617.4_Missense_Mutation_p.Y184C|ZFP64_ENST00000361387.2_Missense_Mutation_p.Y238C|ZFP64_ENST00000371515.4_Missense_Mutation_p.Y236C|ZFP64_ENST00000477786.1_5'UTR	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						GCGGCTGGCGTAGGGGCAGAT	0.587000													121	172					0	0	1	0	0
CTSZ	1522	broad.mit.edu	37	20	57571710	57571710	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:57571710G>A	ENST00000217131.5	-	5	903	c.785C>T	c.(784-786)tCa>tTa	p.S262L		NM_001336.3	NP_001327.2	Q9UBR2	CATZ_HUMAN	cathepsin Z	262					proteolysis	endoplasmic reticulum|extracellular space|lysosome	cysteine-type endopeptidase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(4)	10	all_lung(29;0.00711)		Colorectal(105;0.109)			TTCACCCCATGAATTCCGGAC	0.443000													35	171					0	0	1	0	0
EPN1	29924	broad.mit.edu	37	19	56190126	56190126	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:56190126G>T	ENST00000411543.2	+	3	1013	c.466G>T	c.(466-468)Gac>Tac	p.D156Y	EPN1_ENST00000085079.7_Missense_Mutation_p.D45Y|EPN1_ENST00000270460.6_Missense_Mutation_p.D45Y	NM_001130071.1	NP_001123543.1	Q9Y6I3	EPN1_HUMAN	epsin 1	45					endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|cytoplasm|nucleus|plasma membrane	lipid binding			endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|skin(1)	17		Colorectal(82;0.00244)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.112)		AGAGATTGCCGACCTCACCTA	0.552000													15	61					1.49906e-05	1.54803e-05	1	1	0
PDE11A	50940	broad.mit.edu	37	2	178534241	178534241	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:178534241C>G	ENST00000286063.5	-	18	2859	c.2542G>C	c.(2542-2544)Gag>Cag	p.E848Q	PDE11A_ENST00000358450.4_Missense_Mutation_p.E598Q|PDE11A_ENST00000450799.2_Missense_Mutation_p.E39Q|PDE11A_ENST00000449286.2_Missense_Mutation_p.E490Q|PDE11A_ENST00000409504.1_Missense_Mutation_p.E490Q|PDE11A_ENST00000389683.3_Missense_Mutation_p.E404Q	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	848	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			AGTTTGAGCTCTAATCTCTCC	0.338000									Primary Pigmented Nodular Adrenocortical Disease, Familial				24	136					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1525131	1525131	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:1525131C>A	ENST00000389470.4	-	24	3436	c.3437G>T	c.(3436-3438)gGc>gTc	p.G1146V	INTS1_ENST00000404767.3_Intron			Q8N201	INT1_HUMAN	integrator complex subunit 1	992					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		ATGAGCTGGGCCGGCTTTCGG	0.672000													18	16					9.16793e-09	9.67356e-09	1	1	0
DYRK4	8798	broad.mit.edu	37	12	4714109	4714109	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:4714109C>G	ENST00000540757.2	+	9	971	c.811C>G	c.(811-813)Cga>Gga	p.R271G	DYRK4_ENST00000543431.1_Missense_Mutation_p.R271G|DYRK4_ENST00000010132.5_Missense_Mutation_p.R271G	NM_003845.1	NP_003836.1	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4	271	Protein kinase.					Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27			Colorectal(7;0.103)			CCGGTTCTACCGATCCCCAGA	0.572000											OREG0021598	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	99					0	0	1	0	0
RFWD2	64326	broad.mit.edu	37	1	176050403	176050403	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:176050403G>C	ENST00000367669.3	-	11	1676	c.1162C>G	c.(1162-1164)Cag>Gag	p.Q388E	RFWD2_ENST00000308769.8_Missense_Mutation_p.Q364E	NM_022457.5	NP_071902.2	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2, E3 ubiquitin protein ligase	388					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						TCATCCAACTGGCTTGCAGTT	0.348000													39	91					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42356450	42356450	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:42356450C>T	ENST00000554171.1	+	5	3054	c.622C>T	c.(622-624)Cag>Tag	p.Q208*	LRFN5_ENST00000554120.1_Nonsense_Mutation_p.Q208*|LRFN5_ENST00000298119.4_Nonsense_Mutation_p.Q208*			Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	208						integral to membrane		p.Q208E(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AAATAAATTGCAGAAGCTACC	0.428000										HNSCC(30;0.082)			16	67					0	0	1	0	0
LCOR	84458	broad.mit.edu	37	10	98711923	98711923	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:98711923C>A	ENST00000540664.1	+	7	845	c.302C>A	c.(301-303)tCt>tAt	p.S101Y	LCOR_ENST00000371103.3_Missense_Mutation_p.S101Y|LCOR_ENST00000356016.3_Missense_Mutation_p.S101Y|LCOR_ENST00000371097.4_Missense_Mutation_p.S101Y|LCOR_ENST00000498444.1_3'UTR	NM_001170765.1|NM_001170766.1	NP_001164236.1|NP_001164237.1			ligand dependent nuclear receptor corepressor											endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|ovary(3)|prostate(1)|urinary_tract(1)	13		Colorectal(252;0.162)		Epithelial(162;4.43e-09)|all cancers(201;2.96e-07)		CTGAGCCACTCTCCAGGCTGC	0.453000													49	67					6.77423e-14	7.39469e-14	1	1	0
RUSC1	23623	broad.mit.edu	37	1	155294228	155294228	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:155294228C>T	ENST00000368347.4	+	1	501	c.20C>T	c.(19-21)cCg>cTg	p.P7L	RUSC1_ENST00000368352.5_Intron|RUSC1_ENST00000368354.3_Intron	NM_001105205.1	NP_001098675.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	0						cytoplasm|nucleolus	SH3/SH2 adaptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			ACGTGCTCCCCGGGGCTCCGC	0.721000													15	112					0	0	1	0	0
HM13	81502	broad.mit.edu	37	20	30102373	30102373	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:30102373G>A	ENST00000335574.5	+	1	143	c.19G>A	c.(19-21)Gat>Aat	p.D7N	HM13_ENST00000398174.3_Missense_Mutation_p.D7N|HM13_ENST00000376127.3_Missense_Mutation_p.D7N|HM13_ENST00000340852.5_Missense_Mutation_p.D7N	NM_178580.1	NP_848695.1	Q8TCT9	HM13_HUMAN	histocompatibility (minor) 13	7					membrane protein proteolysis	cell surface|endoplasmic reticulum membrane|integral to membrane|plasma membrane	aspartic-type endopeptidase activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|urinary_tract(1)	12	all_cancers(5;3.44e-05)|Lung NSC(7;4.38e-06)|all_lung(7;7.65e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		all cancers(5;0.000479)|Colorectal(19;0.00202)|COAD - Colon adenocarcinoma(19;0.0264)			GGCCCTCAGCGATCCGCATAA	0.697000													12	25					0	0	1	0	0
TPPP2	122664	broad.mit.edu	37	14	21499292	21499292	+	Nonsense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:21499292G>T	ENST00000321760.6	+	3	443	c.295G>T	c.(295-297)Gag>Tag	p.E99*	TPPP2_ENST00000530140.2_Nonsense_Mutation_p.E99*|TPPP2_ENST00000460647.2_Nonsense_Mutation_p.E99*|NDRG2_ENST00000403829.3_Intron	NM_173846.4	NP_776245.2	P59282	TPPP2_HUMAN	tubulin polymerization-promoting protein family member 2	99						cytoplasm				endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;6.85e-11)|Epithelial(56;9.49e-09)|all cancers(55;3.84e-08)	GBM - Glioblastoma multiforme(265;0.0191)		TGGACTCATGGAGGGCAAAGA	0.522000													17	130					5.3912e-06	5.59915e-06	1	1	0
PPIP5K1	9677	broad.mit.edu	37	15	43827592	43827592	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:43827592G>A	ENST00000420765.1	-	31	3764	c.3582C>T	c.(3580-3582)ttC>ttT	p.F1194F	PPIP5K1_ENST00000381885.1_Silent_p.F1190F|PPIP5K1_ENST00000348806.6_Silent_p.F1167F|PPIP5K1_ENST00000396923.3_Silent_p.F1194F|PPIP5K1_ENST00000381879.4_Silent_p.F1170F|PPIP5K1_ENST00000360135.4_Silent_p.F1167F|PPIP5K1_ENST00000360301.4_Silent_p.F1169F|PPIP5K1_ENST00000334933.4_Silent_p.F1169F	NM_001130858.2	NP_001124330.1	Q6PFW1	VIP1_HUMAN	diphosphoinositol pentakisphosphate kinase 1	1194					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			large_intestine(1)	1						GTTGATCACTGAAGCCAAATT	0.522000													46	66					0	0	1	0	0
GLIPR1L2	144321	broad.mit.edu	37	12	75804327	75804327	+	Missense_Mutation	SNP	T	T	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:75804327T>G	ENST00000550916.1	+	2	395	c.348T>G	c.(346-348)atT>atG	p.I116M	GLIPR1L2_ENST00000435775.1_Missense_Mutation_p.I116M|GLIPR1L2_ENST00000320460.4_Missense_Mutation_p.I116M|GLIPR1L2_ENST00000547164.1_Missense_Mutation_p.I116M|GLIPR1L2_ENST00000378692.3_Missense_Mutation_p.I9M|GLIPR1L2_ENST00000441218.1_Missense_Mutation_p.I51M	NM_001270396.1	NP_001257325.1	Q4G1C9	GRPL2_HUMAN	GLI pathogenesis-related 1 like 2	116						integral to membrane				kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16						TTTATGGTATTGGTGAAAATA	0.348000													60	91					0	0	1	0	0
ZNF574	64763	broad.mit.edu	37	19	42583812	42583812	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:42583812G>C	ENST00000600245.1	+	2	1709	c.1054G>C	c.(1054-1056)Gac>Cac	p.D352H	CTB-59C6.3_ENST00000594531.1_RNA|ZNF574_ENST00000222339.7_Missense_Mutation_p.D442H|ZNF574_ENST00000359044.4_Missense_Mutation_p.D352H			Q6ZN55	ZN574_HUMAN	zinc finger protein 574	352					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	20		Prostate(69;0.059)				TTCCAGTCTGGACCAGCACCT	0.632000													20	92					0	0	1	0	0
ETV3	2117	broad.mit.edu	37	1	157106124	157106124	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:157106124G>A	ENST00000368192.4	-	2	85	c.21C>T	c.(19-21)atC>atT	p.I7I	ETV3_ENST00000326786.4_Silent_p.I7I|ETV3_ENST00000460850.1_5'UTR	NM_001145312.1	NP_001138784.1	P41162	ETV3_HUMAN	ets variant 3	7							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	9	Hepatocellular(266;0.158)	Prostate(1639;0.174)				GCTTTTCCACGATGCTACAGC	0.458000													72	330					0	0	1	0	0
TCEAL2	140597	broad.mit.edu	37	X	101382089	101382089	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:101382089G>A	ENST00000372780.1	+	3	506	c.287G>A	c.(286-288)aGa>aAa	p.R96K	TCEAL2_ENST00000329035.2_Missense_Mutation_p.R96K	NM_080390.3	NP_525129.1	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	96					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						aagccagagagagggggaagg	0.547000													15	10					0	0	1	0	0
ORC2	4999	broad.mit.edu	37	2	201814359	201814359	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:201814359C>G	ENST00000234296.2	-	5	495	c.246G>C	c.(244-246)ttG>ttC	p.L82F	ORC2_ENST00000467605.1_5'UTR	NM_006190.4	NP_006181.1	Q13416	ORC2_HUMAN	origin recognition complex, subunit 2	82					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	20						AGCCATTTTTCAATGATTCTG	0.279000													7	51					0	0	1	0	0
DGCR8	54487	broad.mit.edu	37	22	20079483	20079483	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:20079483C>G	ENST00000351989.3	+	7	2025	c.1596C>G	c.(1594-1596)ttC>ttG	p.F532L	DGCR8_ENST00000407755.1_Missense_Mutation_p.F532L|DGCR8_ENST00000383024.2_Missense_Mutation_p.F532L	NM_022720.6	NP_073557.3	Q8WYQ5	DGCR8_HUMAN	DGCR8 microprocessor complex subunit	532	DRBM 1.|Necessary for heme-binding and pri-miRNA processing.|Necessary for interaction with DROSHA.				primary miRNA processing	cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding			NS(2)|breast(1)|endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	Colorectal(54;0.0993)					TCTATAATTTCTTTGAATGTG	0.502000													8	21					0	0	1	0	0
SNHG12	85028	broad.mit.edu	37	1	28905086	28905086	+	RNA	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:28905086C>T	ENST00000488745.1	-	0	1331				SNHG12_ENST00000483436.1_RNA|SNHG12_ENST00000475441.1_RNA|SNHG12_ENST00000531126.1_RNA																							TTTTATTGATCACCTCTGAAG	0.383000													10	24					0	0	1	0	0
ERBB4	2066	broad.mit.edu	37	2	212530094	212530094	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:212530094C>T	ENST00000342788.4	-	15	2135	c.1825G>A	c.(1825-1827)Gat>Aat	p.D609N	ERBB4_ENST00000402597.1_Missense_Mutation_p.D609N|ERBB4_ENST00000436443.1_Missense_Mutation_p.D609N	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	609	Cys-rich.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity	p.D609N(1)		NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CGATCTGGATCAGCATACTTG	0.473000										TSP Lung(8;0.080)			20	129					0	0	1	0	0
LOC150776	150776	broad.mit.edu	37	2	132276182	132276182	+	RNA	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:132276182G>T	ENST00000438378.2	+	0	1843					NR_026922.1																						GGCCACCAGCGGTCACTGATG	0.632000													3	10					1	1	1	1	0
VANGL2	57216	broad.mit.edu	37	1	160388969	160388969	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:160388969C>G	ENST00000368061.2	+	4	844	c.370C>G	c.(370-372)Ctg>Gtg	p.L124V		NM_020335.2	NP_065068.1	Q9ULK5	VANG2_HUMAN	VANGL planar cell polarity protein 2	124					apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(1)	37	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTCACGCCTCTGGCCTTCCT	0.662000													10	125					0	0	1	0	0
RNF208	727800	broad.mit.edu	37	9	140115059	140115059	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:140115059G>A	ENST00000392827.1	-	2	774	c.606C>T	c.(604-606)gcC>gcT	p.A202A	RNF208_ENST00000391553.1_Silent_p.A202A			Q9H0X6	RN208_HUMAN	ring finger protein 208	202							zinc ion binding			lung(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CAGCCAGCGCGGCCAGGCCGT	0.667000													5	45					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92268677	92268677	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:92268677G>A	ENST00000435962.2	-	4	713	c.390C>T	c.(388-390)ttC>ttT	p.F130F	TC2N_ENST00000340892.5_Silent_p.F130F|TC2N_ENST00000360594.5_Silent_p.F130F|TC2N_ENST00000556018.1_Silent_p.F130F	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	130						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		GATACATATAGAATGGGTTAT	0.438000													10	108					0	0	1	0	0
EXO1	9156	broad.mit.edu	37	1	242030234	242030234	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:242030234G>T	ENST00000366548.3	+	11	1737	c.1144G>T	c.(1144-1146)Ggt>Tgt	p.G382C	EXO1_ENST00000518483.1_Missense_Mutation_p.G382C|EXO1_ENST00000348581.5_Missense_Mutation_p.G382C	NM_130398.3	NP_569082.2	Q9UQ84	EXO1_HUMAN	exonuclease 1	382	Interaction with MSH3.				meiosis|mismatch repair	nucleus	double-stranded DNA specific 5'-3' exodeoxyribonuclease activity|flap endonuclease activity|metal ion binding|protein binding|ribonuclease H activity|single-stranded DNA specific 5'-3' exodeoxyribonuclease activity			NS(1)|central_nervous_system(2)|endometrium(3)|large_intestine(3)|lung(29)|ovary(2)|skin(1)|stomach(2)|urinary_tract(2)	45	Ovarian(103;0.103)	all_cancers(173;0.0555)	OV - Ovarian serous cystadenocarcinoma(106;0.0107)			ACCAGAGTCGGGTACTGTTTC	0.428000								Editing and processing nucleases					16	85					5.03518e-11	5.43113e-11	1	1	0
CLIP1	6249	broad.mit.edu	37	12	122757540	122757540	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:122757540G>A	ENST00000358808.2	-	25	4320	c.4166C>T	c.(4165-4167)tCa>tTa	p.S1389L	CLIP1_ENST00000540539.1_Missense_Mutation_p.S79L|CLIP1_ENST00000361654.4_Missense_Mutation_p.S1278L|CLIP1_ENST00000302528.7_Missense_Mutation_p.S1389L|CLIP1_ENST00000545889.1_Missense_Mutation_p.S975L|CLIP1_ENST00000536634.1_5'UTR|CLIP1_ENST00000540338.1_Missense_Mutation_p.S1400L|CLIP1_ENST00000537178.1_Missense_Mutation_p.S1354L	NM_001247997.1|NM_002956.2	NP_001234926.1|NP_002947.1	P30622	CLIP1_HUMAN	CAP-GLY domain containing linker protein 1	1400					mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			NS(1)|breast(5)|endometrium(4)|kidney(5)|large_intestine(16)|liver(1)|lung(21)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		AGGGTCCTCTGACATCTGTGC	0.522000													32	108					0	0	1	0	0
ADAMTS7	11173	broad.mit.edu	37	15	79058524	79058524	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:79058524C>T	ENST00000388820.4	-	19	3939	c.3729G>A	c.(3727-3729)ttG>ttA	p.L1243L		NM_014272.3	NP_055087.2	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 7	1243					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(23)|ovary(1)|prostate(8)|skin(9)	54						CAACAGGGGACAAAGGGGGCA	0.657000													4	44					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228403334	228403334	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:228403334C>T	ENST00000570156.2	+	6	1973	c.1899C>T	c.(1897-1899)tcC>tcT	p.S633S	OBSCN_ENST00000284548.11_Silent_p.S633S|OBSCN_ENST00000422127.1_Silent_p.S633S|OBSCN_ENST00000366707.4_5'UTR|OBSCN_ENST00000366709.4_5'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	633	Ig-like 6.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TCACTTTCTCCGTGGACCTCA	0.662000													5	6					0	0	1	0	0
PTH2	113091	broad.mit.edu	37	19	49926533	49926533	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:49926533G>C	ENST00000270631.1	-	1	165	c.64C>G	c.(64-66)Ctg>Gtg	p.L22V		NM_178449.3	NP_848544.1	Q96A98	TIP39_HUMAN	parathyroid hormone 2	22					neuropeptide signaling pathway	extracellular region		p.L22V(2)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(262;0.0015)|GBM - Glioblastoma multiforme(486;0.044)|Lung(386;0.0785)|LUSC - Lung squamous cell carcinoma(496;0.0836)		GGCACCACcagcagcagcagc	0.692000													3	46					0	0	1	0	0
NEUROD2	4761	broad.mit.edu	37	17	37761816	37761816	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:37761816G>A	ENST00000302584.4	-	2	1257	c.1037C>T	c.(1036-1038)tCg>tTg	p.S346L		NM_006160.3	NP_006151.3	Q15784	NDF2_HUMAN	neuronal differentiation 2	346					cellular response to calcium ion|cellular response to electrical stimulus|cerebellar cortex development|negative regulation of synapse maturation|positive regulation of calcium-mediated signaling|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of synapse maturation|positive regulation of synaptic plasticity|protein ubiquitination|regulation of transcription from RNA polymerase II promoter	nucleus	E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(4)	8	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Lung(15;0.00549)|LUAD - Lung adenocarcinoma(14;0.0664)			CACAGCCGACGAGCCGAAGAC	0.627000													25	61					0	0	1	0	0
RTN1	6252	broad.mit.edu	37	14	60072181	60072181	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:60072181G>A	ENST00000267484.5	-	5	2352	c.2017C>T	c.(2017-2019)Cag>Tag	p.Q673*	RTN1_ENST00000395090.1_Nonsense_Mutation_p.Q90*|RTN1_ENST00000557422.1_Intron|RTN1_ENST00000342503.4_Nonsense_Mutation_p.Q105*	NM_021136.2	NP_066959.1	Q16799	RTN1_HUMAN	reticulon 1	673	Reticulon.				neuron differentiation	integral to endoplasmic reticulum membrane	signal transducer activity			central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(30)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	49				OV - Ovarian serous cystadenocarcinoma(108;0.0968)		GTGTACTTCTGAATCTGCTCC	0.488000													12	111					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39885319	39885319	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:39885319G>A	ENST00000260356.5	+	18	3051	c.2886G>A	c.(2884-2886)atG>atA	p.M962I		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	962	TSP C-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	GATTCCAGATGATTCCTCTGG	0.493000													29	45					0	0	1	0	0
MGAT4C	25834	broad.mit.edu	37	12	86373411	86373411	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:86373411C>G	ENST00000604798.1	-	8	2297	c.1093G>C	c.(1093-1095)Gat>Cat	p.D365H	MGAT4C_ENST00000548651.1_Missense_Mutation_p.D365H|MGAT4C_ENST00000332156.1_Missense_Mutation_p.D365H|MGAT4C_ENST00000393205.2_Missense_Mutation_p.D394H|MGAT4C_ENST00000552808.2_Missense_Mutation_p.D365H|MGAT4C_ENST00000549405.2_Missense_Mutation_p.D365H			Q9UBM8	MGT4C_HUMAN	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)	365					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(17)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41						AAGTACTCATCAACACTACTG	0.353000													3	45					0	0	1	0	0
ZNF576	79177	broad.mit.edu	37	19	44103336	44103336	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:44103336G>A	ENST00000336564.4	+	3	593	c.439G>A	c.(439-441)Gag>Aag	p.E147K	SRRM5_ENST00000526798.1_Intron|SRRM5_ENST00000607544.1_Intron|ZNF576_ENST00000391965.2_Missense_Mutation_p.E147K|ZNF576_ENST00000525771.1_Missense_Mutation_p.E147K|ZNF576_ENST00000529930.1_Missense_Mutation_p.E147K|ZNF576_ENST00000528387.1_Missense_Mutation_p.E147K|ZNF576_ENST00000533118.1_Missense_Mutation_p.E147K	NM_001145347.1	NP_001138819.1	Q9H609	ZN576_HUMAN	zinc finger protein 576	147					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|prostate(1)	2		Prostate(69;0.0199)				CGCCTGCACAGAGTGCGGTCA	0.607000													23	70					0	0	1	0	0
PDCL3	79031	broad.mit.edu	37	2	101186146	101186146	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:101186146G>A	ENST00000264254.6	+	4	709	c.331G>A	c.(331-333)Gag>Aag	p.E111K		NM_024065.4	NP_076970.1	Q9H2J4	PDCL3_HUMAN	phosducin-like 3	111					apoptosis|interspecies interaction between organisms	cytoplasm	protein binding	p.E111K(1)		endometrium(3)|large_intestine(2)|liver(1)|lung(6)	12						CAAAGCTGGCGAGGGCTTGTG	0.418000													25	155					0	0	1	0	0
SPATA5	166378	broad.mit.edu	37	4	123848876	123848876	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:123848876G>A	ENST00000274008.3	+	2	320	c.251G>A	c.(250-252)cGa>cAa	p.R84Q	SPATA5_ENST00000422835.2_3'UTR	NM_145207.2	NP_660208.2	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	84					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity	p.R84L(1)		endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24						TGTATAGGTCGACCAGTGTTG	0.343000													34	120					0	0	1	0	0
FANCG	2189	broad.mit.edu	37	9	35076490	35076490	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:35076490G>T	ENST00000378643.3	-	8	1506	c.1015C>A	c.(1015-1017)Cat>Aat	p.H339N	FANCG_ENST00000476212.1_Intron	NM_004629.1	NP_004620.1	O15287	FANCG_HUMAN	Fanconi anemia, complementation group G	339					cell cycle checkpoint|DNA repair|mitochondrion organization	mitochondrion|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(7)|ovary(2)|prostate(3)|stomach(1)	28			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTGCCACAATGAAGGGGTGAG	0.532000			"""Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks					20	66					1.96292e-10	2.10479e-10	1	1	0
VCL	7414	broad.mit.edu	37	10	75860836	75860836	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:75860836C>T	ENST00000211998.4	+	14	2097	c.2003C>T	c.(2002-2004)gCc>gTc	p.A668V	VCL_ENST00000417648.2_Intron|VCL_ENST00000478896.2_3'UTR|VCL_ENST00000372755.3_Missense_Mutation_p.A668V	NM_014000.2	NP_054706.1	P18206	VINC_HUMAN	vinculin	668	N-terminal globular head.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	20	Prostate(51;0.0112)					GTGAAGACGGCCCGAGAACTC	0.453000													3	22					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57288375	57288375	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:57288375G>C	ENST00000543872.2	+	2	1227	c.963G>C	c.(961-963)caG>caC	p.Q321H	SMG8_ENST00000580498.1_Intron|SMG8_ENST00000578922.1_Missense_Mutation_p.Q321H|SMG8_ENST00000300917.5_Missense_Mutation_p.Q321H|CTD-2510F5.6_ENST00000577660.1_Intron			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	321					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						TGACTAATCAGAGCATCAACT	0.512000													27	98					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96705546	96705546	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:96705546C>G	ENST00000376747.3	-	1	91	c.21G>C	c.(19-21)acG>acC	p.T7T	UGGT2_ENST00000376712.4_Silent_p.T7T|UGGT2_ENST00000376714.3_Silent_p.T7T|UGGT2_ENST00000397618.3_Silent_p.T7T	NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	7					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						GCACCACGTTCGTGGCTTTCG	0.687000													4	20					0	0	1	0	0
STAT1	6772	broad.mit.edu	37	2	191872321	191872321	+	Missense_Mutation	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:191872321T>C	ENST00000361099.3	-	5	727	c.340A>G	c.(340-342)Aaa>Gaa	p.K114E	STAT1_ENST00000540176.1_Missense_Mutation_p.K114E|STAT1_ENST00000409465.1_Missense_Mutation_p.K114E|STAT1_ENST00000392322.3_Missense_Mutation_p.K114E|STAT1_ENST00000392323.2_Missense_Mutation_p.K116E	NM_007315.3	NP_009330.1	P42224	STAT1_HUMAN	signal transducer and activator of transcription 1, 91kDa	114					activation of caspase activity|I-kappaB kinase/NF-kappaB cascade|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway|tyrosine phosphorylation of STAT protein	cytosol|nucleolus|nucleoplasm	calcium ion binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding|RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity|signal transducer activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(6)|lung(13)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			OV - Ovarian serous cystadenocarcinoma(117;0.00434)|Epithelial(96;0.0555)|all cancers(119;0.141)		Fludarabine(DB01073)	TCCAGAATTTTCCTTTCTTCC	0.299000													19	117					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167045853	167045853	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:167045853G>A	ENST00000392766.2	-	11	1079	c.739C>T	c.(739-741)Ctg>Ttg	p.L247L	ZBBX_ENST00000455345.2_Silent_p.L247L|ZBBX_ENST00000392764.1_Silent_p.L218L|ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000307529.5_Silent_p.L247L|ZBBX_ENST00000392767.2_Silent_p.L247L	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	247						intracellular	zinc ion binding	p.L247V(2)		NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						TCACACAACAGACTCTTTCTT	0.363000													43	194					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65397123	65397123	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:65397123C>G	ENST00000355703.3	+	26	4672	c.4133C>G	c.(4132-4134)tCt>tGt	p.S1378C		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1378						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						GTCCTGGCCTCTGACTACCTC	0.627000													8	5					0	0	1	0	0
GPATCH8	23131	broad.mit.edu	37	17	42483356	42483356	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:42483356C>T	ENST00000434000.1	-	8	604	c.322G>A	c.(322-324)Gag>Aag	p.E108K	GPATCH8_ENST00000591680.1_Missense_Mutation_p.E186K			Q9UKJ3	GPTC8_HUMAN	G patch domain containing 8	186						intracellular	nucleic acid binding|zinc ion binding			breast(4)|endometrium(7)|kidney(6)|large_intestine(4)|liver(2)|lung(21)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.206)		TGTTTTTTCTCATCCTTGCGG	0.423000													35	99					0	0	1	0	0
MDC1	9656	broad.mit.edu	37	6	30681752	30681752	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:30681752C>G	ENST00000376406.3	-	3	992	c.345G>C	c.(343-345)ctG>ctC	p.L115L	MDC1_ENST00000376405.2_Silent_p.L115L	NM_014641.2	NP_055456.2	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	115	Interaction with CHEK2.|Interaction with the MRN complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|kidney(1)|ovary(1)	4						CCTGGTCCCTCAGACGGTGAC	0.552000								Other conserved DNA damage response genes					22	61					0	0	1	0	0
TBCD	6904	broad.mit.edu	37	17	80895219	80895219	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:80895219C>T	ENST00000355528.4	+	35	3394	c.3264C>T	c.(3262-3264)ctC>ctT	p.L1088L	TBCD_ENST00000539345.2_Silent_p.L1088L	NM_005993.4	NP_005984.3	Q9BTW9	TBCD_HUMAN	tubulin folding cofactor D	1088					'de novo' posttranslational protein folding|adherens junction assembly|negative regulation of cell-substrate adhesion|negative regulation of microtubule polymerization|post-chaperonin tubulin folding pathway|tight junction assembly	adherens junction|cytoplasm|lateral plasma membrane|microtubule|tight junction	beta-tubulin binding|chaperone binding|GTPase activator activity					Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0266)|all_epithelial(8;0.0696)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.18)			TCCAGAAGCTCCTGTCAGGCA	0.522000													19	50					0	0	1	0	0
BAG6	7917	broad.mit.edu	37	6	31608003	31608003	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:31608003G>A	ENST00000404765.2	-	24	3508	c.3219C>T	c.(3217-3219)ctC>ctT	p.L1073L	BAG6_ENST00000375964.6_Silent_p.L1043L|BAG6_ENST00000362049.6_Silent_p.L1037L|BAG6_ENST00000211379.5_Silent_p.L1037L|BAG6_ENST00000375976.4_Silent_p.L1037L|BAG6_ENST00000439687.2_Silent_p.L863L			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	1043					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						GCATACCACTGAGGTAGGCAT	0.522000													24	62					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	700152	700152	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:700152C>G	ENST00000549091.1	+	3	356	c.264C>G	c.(262-264)ctC>ctG	p.L88L	WDR90_ENST00000293879.4_Silent_p.L88L	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	88										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				TCATCCACCTCGATGTGTCCT	0.672000													89	621					0	0	1	0	0
ZBTB5	9925	broad.mit.edu	37	9	37442082	37442082	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:37442082G>C	ENST00000307750.4	-	2	655	c.467C>G	c.(466-468)tCa>tGa	p.S156*		NM_014872.2	NP_055687.1	O15062	ZBTB5_HUMAN	zinc finger and BTB domain containing 5	156					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)	8				GBM - Glioblastoma multiforme(29;0.00733)|Lung(182;0.226)		ATTGAGGGCTGAGCTCACGAT	0.622000													17	157					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143081428	143081428	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:143081428C>T	ENST00000367603.2	-	9	6739	c.5997G>A	c.(5995-5997)caG>caA	p.Q1999Q	HIVEP2_ENST00000367604.1_Silent_p.Q1999Q|HIVEP2_ENST00000012134.2_Silent_p.Q1999Q	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1999					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GGAATAGCCTCTGGTATTCTG	0.438000													61	206					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56563387	56563387	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:56563387C>T	ENST00000394023.3	-	25	2746	c.2641G>A	c.(2641-2643)Gag>Aag	p.E881K	SMARCC2_ENST00000347471.4_Missense_Mutation_p.E881K|SMARCC2_ENST00000550164.1_Missense_Mutation_p.E881K|SMARCC2_ENST00000267064.4_Missense_Mutation_p.E850K|RP11-977G19.5_ENST00000553176.1_RNA	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	850					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			ATGtcccgctccacctttgtc	0.617000													15	51					0	0	1	0	0
MYOM3	127294	broad.mit.edu	37	1	24383947	24383947	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:24383947G>C	ENST00000330966.7	-	37	4392	c.4230C>G	c.(4228-4230)gtC>gtG	p.V1410V	MYOM3_ENST00000374434.3_Silent_p.V1407V|MYOM3_ENST00000338909.5_Silent_p.V300V|RP11-293P20.2_ENST00000439239.2_RNA			Q5VTT5	MYOM3_HUMAN	myomesin 3	1407	Ig-like C2-type 4.									NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(3)|lung(40)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	68		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TCTTGACGAAGACGCCGTAGC	0.572000													9	96					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78360641	78360641	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:78360641C>A	ENST00000582970.1	+	63	15015	c.14872C>A	c.(14872-14874)Cgg>Agg	p.R4958R	CTD-2047H16.4_ENST00000575034.1_RNA|RNF213_ENST00000336301.6_Silent_p.R3031R|CTD-2047H16.4_ENST00000573394.1_RNA|CTD-2047H16.4_ENST00000572151.1_RNA|RNF213_ENST00000508628.2_Silent_p.R5007R|RNF213_ENST00000427003.3_3'UTR	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GAAGATTCAGCGGCAGATCGT	0.592000													16	48					9.16793e-09	9.67356e-09	1	1	0
FBXO16	157574	broad.mit.edu	37	8	28321234	28321234	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:28321234C>G	ENST00000380254.2	-	4	385	c.237G>C	c.(235-237)gaG>gaC	p.E79D	FBXO16_ENST00000517436.1_5'UTR|FBXO16_ENST00000346498.2_Missense_Mutation_p.E67D|FBXO16_ENST00000518734.1_Missense_Mutation_p.E67D	NM_001258211.1|NM_172366.3	NP_001245140.1|NP_758954.1	Q8IX29	FBX16_HUMAN	F-box protein 16	79										large_intestine(2)|ovary(1)	3		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.121)|Kidney(114;0.144)|Colorectal(74;0.249)		CTGGAATTTTCTCTTGAAGCT	0.473000													12	48					0	0	1	0	0
ELMSAN1	91748	broad.mit.edu	37	14	74191993	74191993	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:74191993G>C	ENST00000286523.5	-	9	3338	c.2556C>G	c.(2554-2556)ttC>ttG	p.F852L	ELMSAN1_ENST00000394071.2_Missense_Mutation_p.F852L	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		GCACCAGGAAGAAATCCTTCT	0.557000													29	303					0	0	1	0	0
MYH7B	57644	broad.mit.edu	37	20	33583163	33583163	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:33583163G>A	ENST00000262873.7	+	26	2943	c.2851G>A	c.(2851-2853)Gag>Aag	p.E951K		NM_020884.3	NP_065935.2	A7E2Y1	MYH7B_HUMAN	myosin, heavy chain 7B, cardiac muscle, beta	909						membrane|myosin filament	actin binding|ATP binding|motor activity			NS(2)|breast(5)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(19)|ovary(5)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	54			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GGCAGATGCCGAGGAGCGCTG	0.637000													14	54					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7683893	7683893	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:7683893G>T	ENST00000256861.6	-	3	374	c.296C>A	c.(295-297)aCt>aAt	p.T99N	ITIH5_ENST00000397146.2_Missense_Mutation_p.T99N|ITIH5_ENST00000446830.2_5'UTR|ITIH5_ENST00000397145.2_Missense_Mutation_p.T99N	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	99	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CACCTACATAGTGAAGTTGGT	0.493000													35	164					2.51541e-25	2.86182e-25	1	1	0
TRUB1	142940	broad.mit.edu	37	10	116698112	116698112	+	Missense_Mutation	SNP	A	A	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:116698112A>C	ENST00000298746.3	+	1	161	c.100A>C	c.(100-102)Acc>Ccc	p.T34P		NM_139169.4	NP_631908.1	Q8WWH5	TRUB1_HUMAN	TruB pseudouridine (psi) synthase family member 1	34					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding	p.T34P(1)		breast(2)|kidney(2)|large_intestine(1)|lung(5)|urinary_tract(2)	12		Colorectal(252;0.09)|Breast(234;0.174)|Lung NSC(174;0.245)		Epithelial(162;0.00879)|all cancers(201;0.0243)		AATGGCTGCGACCCCGTCAGC	0.637000													7	28					0	0	1	0	0
ZNF365	22891	broad.mit.edu	37	10	64136182	64136182	+	Nonsense_Mutation	SNP	C	C	G	rs11545586		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:64136182C>G	ENST00000395254.3	+	2	510	c.230C>G	c.(229-231)tCa>tGa	p.S77*	ZNF365_ENST00000395255.3_Nonsense_Mutation_p.S77*|ZNF365_ENST00000410046.3_Nonsense_Mutation_p.S77*|ZNF365_ENST00000466727.1_Intron	NM_014951.2	NP_055766.2	Q70YC4	TALAN_HUMAN	zinc finger protein 365	44										breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	Prostate(12;0.0297)|all_hematologic(501;0.228)					GTCACTTCCTCAGAACTCCTG	0.463000													4	80					0	0	1	0	0
OR2Y1	134083	broad.mit.edu	37	5	180166746	180166746	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:180166746G>A	ENST00000307832.2	-	1	353	c.313C>T	c.(313-315)Cta>Tta	p.L105L		NM_001001657.1	NP_001001657.1	Q8NGV0	OR2Y1_HUMAN	olfactory receptor, family 2, subfamily Y, member 1	105					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	20	all_cancers(89;1.25e-05)|all_epithelial(37;4.36e-06)|Renal(175;0.000159)|Lung NSC(126;0.00317)|all_lung(126;0.0041)|Breast(19;0.114)	all_cancers(40;0.0834)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCAGGGCTAGGTAGATGAAG	0.607000													29	44					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164735606	164735606	+	Missense_Mutation	SNP	C	C	G	rs142660909		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:164735606C>G	ENST00000264382.3	-	30	3638	c.3576G>C	c.(3574-3576)ttG>ttC	p.L1192F		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1192	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity	p.L1192L(1)		NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TATAAAAATCCAAGATCCCTC	0.328000										HNSCC(35;0.089)			16	78					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50265262	50265262	+	Splice_Site	SNP	A	A	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:50265262A>C	ENST00000246801.3	-	2	480	c.399_splice	c.e2+1	p.L133_splice		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	133							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GGCCCTCACCAGGATTTCCGT	0.612000													11	52					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156626863	156626863	+	Silent	SNP	A	A	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:156626863A>C	ENST00000329117.4	+	10	2520	c.2184A>C	c.(2182-2184)acA>acC	p.T728T	BCAN_ENST00000496038.1_3'UTR|RP11-284F21.7_ENST00000448869.1_RNA	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	728	C-type lectin.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					GCATCAGCACACCCGAGGAAC	0.622000													31	84					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576398	158576398	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:158576398C>G	ENST00000361284.1	+	1	170	c.170C>G	c.(169-171)aCc>aGc	p.T57S		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	57					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					CATCTGCACACCCCCATGTAC	0.517000													95	297					0	0	1	0	0
ZNF221	7638	broad.mit.edu	37	19	44471056	44471056	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:44471056C>T	ENST00000251269.5	+	6	1730	c.1402C>T	c.(1402-1404)Cac>Tac	p.H468Y	ZNF221_ENST00000592350.1_Missense_Mutation_p.H468Y|ZNF221_ENST00000587682.1_Missense_Mutation_p.H468Y	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				TCTTGAGTTTCACCAGAGGGT	0.473000													28	53					0	0	1	0	0
SS18L1	26039	broad.mit.edu	37	20	60736626	60736626	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:60736626G>C	ENST00000331758.3	+	4	392	c.366G>C	c.(364-366)caG>caC	p.Q122H	SS18L1_ENST00000370848.4_Missense_Mutation_p.Q125H|SS18L1_ENST00000421564.1_Missense_Mutation_p.Q122H	NM_198935.1	NP_945173.1	O75177	CREST_HUMAN	synovial sarcoma translocation gene on chromosome 18-like 1	122	N-terminal auto-inhibitory domain; necessary for interaction with SMARCA4/BRG1 (By similarity).				chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore			SS18L1/SSX1(2)	ovary(2)|skin(1)	3	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			TGCAGGGCCAGATTGGCAACG	0.701000			T	SSX1	synovial sarcoma								19	97					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238287660	238287660	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:238287660G>A	ENST00000295550.4	-	6	2568	c.2116C>T	c.(2116-2118)Ctg>Ttg	p.L706L	COL6A3_ENST00000346358.4_Intron|COL6A3_ENST00000409809.1_Silent_p.L500L|COL6A3_ENST00000392003.2_Silent_p.L299L|COL6A3_ENST00000353578.4_Silent_p.L500L|COL6A3_ENST00000347401.3_Silent_p.L505L|COL6A3_ENST00000392004.3_Silent_p.L500L|COL6A3_ENST00000472056.1_Intron	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	706	Nonhelical region.|VWFA 4.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGCTGCCTCAGATGACCAAGG	0.493000													12	64					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65907073	65907073	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:65907073G>C	ENST00000321892.4	+	13	3512	c.3451G>C	c.(3451-3453)Gag>Cag	p.E1151Q	BPTF_ENST00000306378.6_Missense_Mutation_p.E1025Q|BPTF_ENST00000424123.3_Missense_Mutation_p.E1012Q|BPTF_ENST00000335221.5_Missense_Mutation_p.E1151Q			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1151					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			CATGAAAACAGAGTCACATGT	0.373000													18	62					0	0	1	0	0
ANKRD20A5P	440482	broad.mit.edu	37	18	14183687	14183687	+	RNA	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:14183687G>A	ENST00000581935.1	+	0	538																				lung(3)	3						GTGGCCATGTGAAAGTGGTCA	0.393000													24	291					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107040265	107040265	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:107040265C>T	ENST00000409886.3	-	20	4245	c.4158G>A	c.(4156-4158)caG>caA	p.Q1386Q	RGPD3_ENST00000304514.7_Silent_p.Q1386Q	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1386	RanBD1 2.				intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TATCATAATTCTGTAAAATCT	0.343000													103	414					0	0	1	0	0
PER3	8863	broad.mit.edu	37	1	7858730	7858730	+	Nonsense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:7858730G>T	ENST00000377532.3	+	6	1014	c.790G>T	c.(790-792)Gaa>Taa	p.E264*	PER3_ENST00000361923.2_Nonsense_Mutation_p.E263*|PER3_ENST00000377541.1_Nonsense_Mutation_p.E263*			P56645	PER3_HUMAN	period circadian clock 3	263	PAS 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			breast(4)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	39	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		CTCTGGTTATGAAGGTAAGTC	0.428000													11	86					1.08611e-07	1.13775e-07	1	1	0
CHEK2	11200	broad.mit.edu	37	22	29130664	29130664	+	Missense_Mutation	SNP	T	T	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:29130664T>G	ENST00000382580.2	-	2	121	c.46A>C	c.(46-48)Agt>Cgt	p.S16R	CHEK2_ENST00000405598.1_Missense_Mutation_p.S16R|CHEK2_ENST00000382565.1_Missense_Mutation_p.S16R|CHEK2_ENST00000544772.1_5'UTR|CHEK2_ENST00000404276.1_Missense_Mutation_p.S16R|CHEK2_ENST00000382566.1_Missense_Mutation_p.S16R|CHEK2_ENST00000328354.6_Missense_Mutation_p.S16R|CHEK2_ENST00000348295.3_Missense_Mutation_p.S16R|CHEK2_ENST00000402731.1_Missense_Mutation_p.S16R|CHEK2_ENST00000403642.1_Missense_Mutation_p.S16R|CHEK2_ENST00000382578.1_Missense_Mutation_p.S16R	NM_001005735.1	NP_001005735.1	O96017	CHK2_HUMAN	checkpoint kinase 2	16					cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						GAACAGGCACTGCTGCCATGA	0.547000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					19	105					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62923220	62923220	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:62923220G>A	ENST00000251157.5	-	48	6369	c.6336C>T	c.(6334-6336)gtC>gtT	p.V2112V	DOCK7_ENST00000340370.5_Silent_p.V2092V	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	2123					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TGTGGCAGGTGACAGGCAATA	0.408000													33	88					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54665969	54665969	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:54665969C>G	ENST00000376591.4	-	11	1704	c.1573G>C	c.(1573-1575)Gag>Cag	p.E525Q	TMC4_ENST00000301187.4_Missense_Mutation_p.E519Q|TMC4_ENST00000416963.1_Missense_Mutation_p.E107Q	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	525						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					ACCTGGAACTCCTGGGTCCCC	0.682000													4	24					0	0	1	0	0
RAB11FIP4	84440	broad.mit.edu	37	17	29761112	29761112	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:29761112C>T	ENST00000325874.8	+	3	537	c.308C>T	c.(307-309)gCg>gTg	p.A103V		NM_032932.3	NP_116321.2	Q86YS3	RFIP4_HUMAN	RAB11 family interacting protein 4 (class II)	103	Necessary for interaction with RAB11A, subcellular location, homo- or heterooligomerization.				cytokinesis|interspecies interaction between organisms|protein transport	cleavage furrow|endocytic vesicle|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding	p.?(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(10;3.62e-13)|all_epithelial(10;0.000387)|all_lung(9;0.0132)|Breast(31;0.014)|all_hematologic(16;0.015)|Myeloproliferative disorder(56;0.0255)|Acute lymphoblastic leukemia(14;0.0259)|Ovarian(249;0.0423)|Lung NSC(157;0.066)				CTGCCGTGCGCGCCAGAGATC	0.632000													7	20					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62856867	62856867	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:62856867C>G	ENST00000584306.1	-	11	3927	c.3397G>C	c.(3397-3399)Gat>Cat	p.D1133H	LRRC37A3_ENST00000334962.5_Missense_Mutation_p.D110H|LRRC37A3_ENST00000339474.5_Missense_Mutation_p.D251H|LRRC37A3_ENST00000319651.5_Missense_Mutation_p.D1133H|LRRC37A3_ENST00000400877.3_Missense_Mutation_p.D171H	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1133						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						GATTTCACATCTAGGTTAACG	0.438000													94	260					0	0	1	0	0
KIF27	55582	broad.mit.edu	37	9	86530305	86530305	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:86530305G>T	ENST00000297814.2	-	2	345	c.202C>A	c.(202-204)Cta>Ata	p.L68I	KIF27_ENST00000413982.1_Missense_Mutation_p.L68I|KIF27_ENST00000334204.2_Missense_Mutation_p.L68I	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	68	Kinesin-motor.				cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						GACAACACTAGGGGCTTTATA	0.398000													23	80					1.55795e-14	1.7032e-14	1	1	0
CUX2	23316	broad.mit.edu	37	12	111745014	111745014	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:111745014G>A	ENST00000261726.6	+	12	1216	c.1062G>A	c.(1060-1062)gaG>gaA	p.E354E		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	354						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						AGCTGGAAGAGAAGCTCCAGG	0.587000													19	74					0	0	1	0	0
GSTT1	2952	broad.mit.edu	37	22	24379450	24379450	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:24379450C>T	ENST00000248935.5	-	3	314	c.262G>A	c.(262-264)Gac>Aac	p.D88N	GSTT1_ENST00000439996.2_5'UTR	NM_000853.2	NP_000844.2	P30711	GSTT1_HUMAN	glutathione S-transferase theta 1	88	GST C-terminal.				glutathione metabolic process	cytosol|soluble fraction	glutathione peroxidase activity|glutathione transferase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|ovary(1)|prostate(1)|skin(1)	6					Glutathione(DB00143)	GCCTGCAGGTCCTGAGGGTAC	0.612000									Myelodysplasia and Acute Myeloid Leukemia (AML), Familial				21	26					0	0	1	0	0
LOC644669	644669	broad.mit.edu	37	18	15316720	15316720	+	RNA	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:15316720C>T	ENST00000455308.2	-	0	703					NR_027417.1																						GGTGTTCTTTCTGCCAAGGGT	0.418000													4	11					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104152938	104152938	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:104152938C>A	ENST00000388887.2	+	65	7339	c.7135C>A	c.(7135-7137)Cac>Aac	p.H2379N	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2379	FAS1 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CATCGAGCACCACCTCGCCAA	0.488000													19	189					1.55795e-14	1.7032e-14	1	1	0
EPS15	2060	broad.mit.edu	37	1	51913718	51913718	+	Splice_Site	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:51913718C>A	ENST00000371733.3	-	9	747	c.651_splice	c.e9+1	p.T217_splice	EPS15_ENST00000371730.2_Splice_Site_p.T217_splice	NM_001981.2	NP_001972.1	P42566	EPS15_HUMAN	epidermal growth factor receptor pathway substrate 15	217					cell proliferation|clathrin coat assembly|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|protein transport	cytosol|early endosome membrane	calcium ion binding|SH3 domain binding	p.0?(1)		endometrium(3)|kidney(5)|large_intestine(8)|lung(13)|prostate(2)|skin(1)|stomach(1)|urinary_tract(2)	35						ATATACTGACCGTTTTTCTCT	0.468000			T	MLL	ALL								31	103					6.00712e-18	6.69813e-18	1	1	0
SLC35G2	80723	broad.mit.edu	37	3	136573862	136573862	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:136573862C>G	ENST00000446465.2	+	2	1188	c.560C>G	c.(559-561)tCa>tGa	p.S187*	RP11-85F14.5_ENST00000470236.1_RNA|RP11-85F14.5_ENST00000461864.1_RNA|SLC35G2_ENST00000393079.3_Nonsense_Mutation_p.S187*|RP11-85F14.5_ENST00000474250.1_RNA	NM_025246.2	NP_079522.2	Q8TBE7	TMM22_HUMAN	solute carrier family 35, member G2	187	DUF6 1.					Golgi apparatus|integral to membrane											ACATCATTTTCAATAGTTCCT	0.418000													46	186					0	0	1	0	0
WNT8A	7478	broad.mit.edu	37	5	137426400	137426400	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:137426400G>C	ENST00000506684.1	+	5	984	c.748G>C	c.(748-750)Gag>Cag	p.E250Q	WNT8A_ENST00000398754.1_Missense_Mutation_p.E232Q			Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family, member 8A	232					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			GAACAGCGCCGAGGGCCACTG	0.547000													8	57					0	0	1	0	0
SOX6	55553	broad.mit.edu	37	11	16119177	16119177	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:16119177C>T	ENST00000352083.6	-	8	1033	c.956G>A	c.(955-957)gGa>gAa	p.G319E	SOX6_ENST00000396356.3_Missense_Mutation_p.G319E|SOX6_ENST00000527619.1_Missense_Mutation_p.G322E|SOX6_ENST00000528429.1_Missense_Mutation_p.G319E|SOX6_ENST00000528252.1_Missense_Mutation_p.G319E|SOX6_ENST00000316399.6_Missense_Mutation_p.G319E			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	319					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						AGGGCTGAGTCCAGAAGCAGC	0.448000													10	56					0	0	1	0	0
MIR182	406958	broad.mit.edu	37	7	129410232	129410232	+	RNA	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:129410232G>A	ENST00000385255.1	-	0	100					NR_029614.1																						GGTGCCGGCTGAGTCCTCGCC	0.622000													12	27					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48559526	48559526	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:48559526C>A	ENST00000358350.4	-	34	4673	c.4069G>T	c.(4069-4071)Gga>Tga	p.G1357*	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507873.2_5'UTR|FRYL_ENST00000503238.1_Nonsense_Mutation_p.G1357*|FRYL_ENST00000537810.1_Nonsense_Mutation_p.G1357*|FRYL_ENST00000507711.1_Nonsense_Mutation_p.G1357*	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	1357					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding	p.G1357R(1)		breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						TGTGGAGATCCCCATCCTTCT	0.418000													39	106					7.63091e-17	8.41832e-17	1	1	0
BAGE2	85319	broad.mit.edu	37	21	11038756	11038756	+	RNA	SNP	A	A	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr21:11038756A>C	ENST00000470054.1	-	0	1447									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACCAGGAGAAAATTTTCTCTT	0.378000													16	218					0	0	1	0	0
PDLIM5	10611	broad.mit.edu	37	4	95539174	95539174	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:95539174C>T	ENST00000317968.4	+	8	1076	c.940C>T	c.(940-942)Ccg>Tcg	p.P314S	PDLIM5_ENST00000542407.1_Missense_Mutation_p.P192S|PDLIM5_ENST00000514743.1_Missense_Mutation_p.P343S|PDLIM5_ENST00000380176.3_3'UTR|PDLIM5_ENST00000437932.1_Missense_Mutation_p.P205S	NM_001256428.1|NM_006457.4	NP_001243357.1|NP_006448.4	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5	314					regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		GGAGCCTTCTCCGCAGTTGGC	0.502000													8	59					0	0	1	0	0
C8orf76	84933	broad.mit.edu	37	8	124238837	124238837	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:124238837G>A	ENST00000276704.4	-	5	902	c.851C>T	c.(850-852)tCg>tTg	p.S284L	ZHX1-C8ORF76_ENST00000357082.4_Missense_Mutation_p.S252L|C8orf76_ENST00000521310.1_5'UTR	NM_032847.2	NP_116236.1	Q96K31	CH076_HUMAN	chromosome 8 open reading frame 76	284							binding	p.S284L(1)		NS(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(4)	17	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			CAAAGCAAACGATGTTTGCTG	0.443000													24	64					0	0	1	0	0
TAS2R40	259286	broad.mit.edu	37	7	142919810	142919810	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:142919810C>T	ENST00000408947.3	+	1	681	c.639C>T	c.(637-639)gcC>gcT	p.A213A		NM_176882.1	NP_795363.1	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	213					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	8	Melanoma(164;0.059)					TCCTGGCAGCCACCCTGCTGA	0.512000													19	139					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897474	153897474	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:153897474G>C	ENST00000511601.1	+	12	3219	c.3031G>C	c.(3031-3033)Gag>Cag	p.E1011Q	FHDC1_ENST00000260008.3_Missense_Mutation_p.E1011Q			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1011					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					CGAGGGCCCTGAGAGTCCCAA	0.617000													35	112					0	0	1	0	0
SETX	23064	broad.mit.edu	37	9	135203861	135203861	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:135203861C>G	ENST00000372169.2	-	10	3306	c.3124G>C	c.(3124-3126)Gag>Cag	p.E1042Q	SETX_ENST00000224140.5_Missense_Mutation_p.E1042Q|SETX_ENST00000393220.1_Missense_Mutation_p.E1042Q			Q7Z333	SETX_HUMAN	senataxin	1042					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TGTTCCCTCTCAAGGCATATT	0.388000													47	177					0	0	1	0	0
TBC1D8	11138	broad.mit.edu	37	2	101667061	101667061	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:101667061C>G	ENST00000409318.1	-	5	804	c.674G>C	c.(673-675)aGa>aCa	p.R225T	TBC1D8_ENST00000376840.4_Missense_Mutation_p.R210T	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	210					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						ATTGGACGTTCTTTCTAATTT	0.423000													16	103					0	0	1	0	0
MOB1B	92597	broad.mit.edu	37	4	71847739	71847739	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:71847739G>A	ENST00000309395.2	+	6	817	c.616G>A	c.(616-618)Gaa>Aaa	p.E206K	MOB1B_ENST00000511449.1_Intron|MOB1B_ENST00000396051.2_Missense_Mutation_p.E211K	NM_001244766.1|NM_173468.3	NP_001231695.1|NP_775739.1	Q7L9L4	MOL1A_HUMAN	MOB kinase activator 1B	206					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding										ACCACTCCAAGAACTGATTGA	0.353000													10	66					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160273951	160273951	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:160273951C>A	ENST00000264431.4	+	21	3916	c.3497C>A	c.(3496-3498)tCa>tAa	p.S1166*		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	1166	Ser-rich.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity	p.S1154*(1)		breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		GTGCCAGTCTCACTGCACGAT	0.483000													22	92					3.8784e-16	4.27212e-16	1	1	0
SPTBN5	51332	broad.mit.edu	37	15	42170729	42170729	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:42170729C>T	ENST00000320955.6	-	17	3508	c.3281G>A	c.(3280-3282)cGg>cAg	p.R1094Q		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	1094					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GCGCCGGGCCCGTTGGGCCAC	0.642000													11	16					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80707383	80707383	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:80707383C>G	ENST00000458043.2	+	30	3557	c.3551C>G	c.(3550-3552)tCa>tGa	p.S1184*	OTOGL_ENST00000547103.1_Nonsense_Mutation_p.S1184*	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						GAAGGAATATCAATTCATTGG	0.358000													23	117					0	0	1	0	0
PRPF38A	84950	broad.mit.edu	37	1	52871462	52871462	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:52871462C>G	ENST00000257181.9	+	2	427	c.241C>G	c.(241-243)Caa>Gaa	p.Q81E	PRPF38A_ENST00000474048.1_Intron	NM_032864.3	NP_116253.2	Q8NAV1	PR38A_HUMAN	pre-mRNA processing factor 38A	81					mRNA processing|RNA splicing	spliceosomal complex				cervix(2)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|stomach(1)	9						GCTTCAAATTCAACCCGAGAA	0.378000													26	106					0	0	1	0	0
SENP1	29843	broad.mit.edu	37	12	48468561	48468561	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:48468561C>T	ENST00000004980.5	-	7	1046	c.568G>A	c.(568-570)Gaa>Aaa	p.E190K	SENP1_ENST00000339976.6_3'UTR|SENP1_ENST00000549595.1_Missense_Mutation_p.E190K|SENP1_ENST00000551330.1_Missense_Mutation_p.E190K|SENP1_ENST00000448372.1_Missense_Mutation_p.E190K|SENP1_ENST00000549518.1_Missense_Mutation_p.E190K			Q9P0U3	SENP1_HUMAN	SUMO1/sentrin specific peptidase 1	190					activation of caspase activity|induction of apoptosis by extracellular signals|protein desumoylation|proteolysis	cytoplasm|nucleus	endopeptidase activity|SUMO-specific protease activity			large_intestine(3)|lung(1)|pancreas(2)|stomach(1)	7		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)				ATCTCTCTTTCTTCTTCTTGA	0.363000													4	26					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1919486	1919486	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:1919486G>A	ENST00000382722.5	-	29	3041	c.2679C>T	c.(2677-2679)atC>atT	p.I893I	CACNA2D4_ENST00000588077.1_Silent_p.I829I|CACNA2D4_ENST00000538450.1_Silent_p.I23I|CACNA2D4_ENST00000587995.1_Silent_p.I868I|CACNA2D4_ENST00000586184.1_Silent_p.I893I|CACNA2D4_ENST00000538027.2_Silent_p.I38I|CACNA2D4_ENST00000585732.1_Silent_p.I754I|CACNA2D4_ENST00000585708.1_Silent_p.I829I	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	893						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CGTTGTTGTCGATGACGAAGC	0.592000													14	54					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101095322	101095322	+	Silent	SNP	T	T	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:101095322T>A	ENST00000369162.2	-	21	3602	c.3258A>T	c.(3256-3258)gcA>gcT	p.A1086A		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1086	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CAATTCTAGCTGCATTCTAAA	0.378000													16	34					0	0	1	0	0
NR5A1	2516	broad.mit.edu	37	9	127265451	127265451	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:127265451C>G	ENST00000373588.4	-	3	347	c.151G>C	c.(151-153)Gag>Cag	p.E51Q		NM_004959.4	NP_004950.2	Q13285	STF1_HUMAN	nuclear receptor subfamily 5, group A, member 1	51					cell-cell signaling|male gonad development|positive regulation of transcription from RNA polymerase II promoter|primary sex determination|regulation of steroid biosynthetic process|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|phospholipid binding|steroid hormone receptor activity|transcription coactivator activity|zinc ion binding			lung(1)|upper_aerodigestive_tract(1)	2						CTCTGGCTCTCGGTGCACGTG	0.652000													4	12					0	0	1	0	0
LILRA6	79168	broad.mit.edu	37	19	54746116	54746116	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:54746116G>C	ENST00000440558.2	-	3	189	c.141C>G	c.(139-141)atC>atG	p.I47M	LILRA6_ENST00000270464.5_Missense_Mutation_p.I47M|LILRA6_ENST00000245621.5_Missense_Mutation_p.I47M|LILRB3_ENST00000407860.2_Missense_Mutation_p.I47M|LILRA6_ENST00000396365.2_Missense_Mutation_p.I47M|LILRA6_ENST00000391735.3_Missense_Mutation_p.I47M|LILRA6_ENST00000419410.2_Missense_Mutation_p.I47M					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6											central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(20)|ovary(3)|skin(2)|urinary_tract(2)	38	all_cancers(19;0.00723)|all_epithelial(19;0.00389)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		CCTGACACCAGATGGTCACGG	0.592000													33	193					0	0	1	0	0
TFDP2	7029	broad.mit.edu	37	3	141712399	141712399	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:141712399C>T	ENST00000499676.2	-	6	825	c.154G>A	c.(154-156)Gac>Aac	p.D52N	TFDP2_ENST00000489671.1_Missense_Mutation_p.D113N|TFDP2_ENST00000486111.1_Missense_Mutation_p.D52N|TFDP2_ENST00000477292.1_Intron|TFDP2_ENST00000310282.6_Missense_Mutation_p.D52N|TFDP2_ENST00000467072.1_Missense_Mutation_p.D52N|TFDP2_ENST00000464782.1_Intron|TFDP2_ENST00000397991.4_Missense_Mutation_p.D85N|TFDP2_ENST00000479040.1_Missense_Mutation_p.D52N|TFDP2_ENST00000317104.7_Intron|TFDP2_ENST00000495310.1_Missense_Mutation_p.D16N	NM_001178139.1	NP_001171610.1	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization partner 2)	113					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)|upper_aerodigestive_tract(2)	3						AAATCAGAGTCTATAAATTTT	0.289000													14	57					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154523788	154523788	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:154523788C>G	ENST00000409959.3	+	23	2597	c.2548C>G	c.(2548-2550)Ctc>Gtc	p.L850V	KIAA0922_ENST00000440693.1_Missense_Mutation_p.L766V|KIAA0922_ENST00000409663.3_Missense_Mutation_p.L849V	NM_001131007.1	NP_001124479.1	A2VDJ0	T131L_HUMAN	KIAA0922	849						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				CAATGTGACTCTCCCTCATCA	0.517000													46	137					0	0	1	0	0
ICA1L	130026	broad.mit.edu	37	2	203682252	203682252	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:203682252C>T	ENST00000392237.2	-	7	730	c.573G>A	c.(571-573)gtG>gtA	p.V191V	ICA1L_ENST00000358299.2_Silent_p.V191V	NM_138468.4	NP_612477.3	Q8NDH6	ICA1L_HUMAN	islet cell autoantigen 1,69kDa-like	191	AH.									breast(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TGCTATTTCTCACTTGCATCT	0.313000													18	66					0	0	1	0	0
OR2B3	442184	broad.mit.edu	37	6	29054106	29054106	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:29054106C>T	ENST00000377173.2	-	1	984	c.920G>A	c.(919-921)aGa>aAa	p.R307K		NM_001005226.2	NP_001005226.1			olfactory receptor, family 2, subfamily B, member 3											breast(1)|endometrium(1)|kidney(2)|lung(17)|prostate(1)|skin(2)	24						GAAAAAGATTCTTGGCATCAG	0.373000													8	57					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152751714	152751714	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:152751714C>T	ENST00000367255.5	-	35	5193	c.4592G>A	c.(4591-4593)aGa>aAa	p.R1531K	SYNE1_ENST00000341594.5_Missense_Mutation_p.R1601K|SYNE1_ENST00000265368.4_Missense_Mutation_p.R1531K|SYNE1_ENST00000367253.4_Missense_Mutation_p.R1531K|SYNE1_ENST00000423061.1_Missense_Mutation_p.R1538K|SYNE1_ENST00000448038.1_Missense_Mutation_p.R1538K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1531					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCCCCGTATCTTCTTATTTG	0.428000										HNSCC(10;0.0054)			55	197					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54163485	54163485	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:54163485C>G	ENST00000265572.3	-	2	410	c.113G>C	c.(112-114)aGc>aCc	p.S38T	OPRK1_ENST00000520287.1_Missense_Mutation_p.S38T	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	38					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GCTGCCGTTGCTGTCGGGCTC	0.716000													6	41					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53619633	53619633	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:53619633C>T	ENST00000357758.3	-	1	367	c.184G>A	c.(184-186)Gaa>Aaa	p.E62K	DDHD1_ENST00000323669.5_Missense_Mutation_p.E62K|DDHD1_ENST00000395606.1_Missense_Mutation_p.E62K	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	62					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					AGCCCGGGTTCCCCGCGCAGC	0.716000													6	36					0	0	1	0	0
B3GALT4	8705	broad.mit.edu	37	6	33245798	33245798	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:33245798G>C	ENST00000451237.1	+	1	882	c.602G>C	c.(601-603)aGa>aCa	p.R201T		NM_003782.3	NP_003773.1	O96024	B3GT4_HUMAN	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	201					protein glycosylation	Golgi membrane|integral to membrane	ganglioside galactosyltransferase activity|UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|pancreas(1)|prostate(1)|soft_tissue(1)|urinary_tract(2)	13						CAATGGGAGAGAAGCACGGAA	0.602000													30	118					0	0	1	0	0
CNTN3	5067	broad.mit.edu	37	3	74350654	74350654	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:74350654C>T	ENST00000263665.6	-	15	2017	c.1990G>A	c.(1990-1992)Gag>Aag	p.E664K		NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	664	Fibronectin type-III 1.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		GGGTTTAACTCAACTACAGTG	0.428000													35	93					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476532	120476532	+	Missense_Mutation	SNP	A	A	G	rs56225594		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:120476532A>G	ENST00000355622.6	+	3	2227	c.2126A>G	c.(2125-2127)tAc>tGc	p.Y709C	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Missense_Mutation_p.Y669C	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	709	TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TGCCTTCACTACAGAGACTTT	0.468000													47	90					0	0	1	0	0
SASH3	54440	broad.mit.edu	37	X	128926602	128926602	+	Splice_Site	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:128926602G>A	ENST00000356892.3	+	6	705		c.e6-1			NM_018990.3	NP_061863.1	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3											breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	12						tccccCAACAGAAAGGAGATG	0.537000													60	57					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32108194	32108194	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:32108194G>C	ENST00000438447.1	+	25	8861	c.8473G>C	c.(8473-8475)Gaa>Caa	p.E2825Q	CTD-2152M20.2_ENST00000503441.1_RNA|PDZD2_ENST00000282493.3_Missense_Mutation_p.E2825Q|PDZD2_ENST00000513490.1_3'UTR			O15018	PDZD2_HUMAN	PDZ domain containing 2	2825	PDZ 6.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GTCTGTCCCAGAAGGACCTGT	0.363000													16	62					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103270624	103270624	+	Splice_Site	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:103270624C>A	ENST00000428762.1	-	20	2625		c.e20-1		RELN_ENST00000343529.5_Splice_Site|RELN_ENST00000424685.2_Splice_Site	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin						axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GGAGATTATTCTAGAGAAAAA	0.338000													23	50					4.26978e-12	4.61237e-12	1	1	0
TG	7038	broad.mit.edu	37	8	133953692	133953692	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:133953692C>T	ENST00000220616.4	+	26	5178	c.5138C>T	c.(5137-5139)tCa>tTa	p.S1713L	TG_ENST00000377869.1_Missense_Mutation_p.S1656L|TG_ENST00000542445.1_Intron	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1713					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		TTCTCAGCCTCAGGAGCCAAT	0.498000													24	204					0	0	1	0	0
RNF111	54778	broad.mit.edu	37	15	59323899	59323899	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:59323899C>G	ENST00000348370.4	+	2	1311	c.878C>G	c.(877-879)tCa>tGa	p.S293*	RNF111_ENST00000557998.1_Nonsense_Mutation_p.S293*|RNF111_ENST00000561186.1_Nonsense_Mutation_p.S293*|RNF111_ENST00000434298.1_Nonsense_Mutation_p.S293*|RNF111_ENST00000559209.1_Nonsense_Mutation_p.S293*	NM_001270528.1|NM_001270529.1|NM_017610.7	NP_001257457.1|NP_001257458.1|NP_060080.6	Q6ZNA4	RN111_HUMAN	ring finger protein 111	293	Interaction with AXIN1.|Ser-rich.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(11)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35				all cancers(107;0.194)		GCTGTTCCCTCAGGTAAAAAT	0.368000													44	53					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21393038	21393038	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:21393038G>C	ENST00000313654.9	+	14	2000	c.1759G>C	c.(1759-1761)Gac>Cac	p.D587H	LAMA3_ENST00000399516.3_Missense_Mutation_p.D587H	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	587	Domain V.|Laminin EGF-like 5.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CAGTGCTTGTGACCCAGCTGG	0.328000													6	56					0	0	1	0	0
CHAF1A	10036	broad.mit.edu	37	19	4430573	4430573	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:4430573G>A	ENST00000301280.5	+	11	1983	c.1882G>A	c.(1882-1884)Gaa>Aaa	p.E628K	CTB-50L17.5_ENST00000590159.1_RNA	NM_005483.2	NP_005474.2	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	628					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	27		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGAGAGGATGAAGATGAGGA	0.473000								Chromatin Structure					13	117					0	0	1	0	0
GINS4	84296	broad.mit.edu	37	8	41394734	41394734	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:41394734G>A	ENST00000523277.2	+	4	386	c.219G>A	c.(217-219)ctG>ctA	p.L73L	GINS4_ENST00000518671.1_Silent_p.L73L|RP11-360L9.4_ENST00000523081.1_RNA|GINS4_ENST00000520710.1_Silent_p.L73L|GINS4_ENST00000276533.3_Silent_p.L73L			Q9BRT9	SLD5_HUMAN	GINS complex subunit 4 (Sld5 homolog)	73					DNA strand elongation involved in DNA replication|S phase of mitotic cell cycle	cytoplasm|nucleoplasm				breast(1)|lung(2)|skin(1)	4	Ovarian(28;0.014)|Colorectal(14;0.0202)|Lung SC(25;0.211)	all_lung(54;0.00732)|Lung NSC(58;0.0207)|Hepatocellular(245;0.0462)|Esophageal squamous(32;0.0844)	Colorectal(10;0.0014)|OV - Ovarian serous cystadenocarcinoma(14;0.00329)|LUSC - Lung squamous cell carcinoma(45;0.0137)|COAD - Colon adenocarcinoma(11;0.0147)			GGGAGGACCTGAAGGTCAGCA	0.463000													49	49					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7810438	7810438	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:7810438G>C	ENST00000315599.7	-	4	736	c.714C>G	c.(712-714)atC>atG	p.I238M	CD209_ENST00000394173.4_Intron|CD209_ENST00000593660.1_Intron|CD209_ENST00000602261.1_Intron|CD209_ENST00000315591.8_Missense_Mutation_p.I214M|CD209_ENST00000301357.8_Missense_Mutation_p.I102M|CD209_ENST00000204801.8_Missense_Mutation_p.I194M|CD209_ENST00000601256.1_Missense_Mutation_p.I214M|CD209_ENST00000354397.6_Missense_Mutation_p.I238M|CD209_ENST00000601951.1_Missense_Mutation_p.I214M|CD209_ENST00000593821.1_Intron|CD209_ENST00000394161.5_Intron	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	238	7 X approximate tandem repeats.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						GCTCCTGGTAGATCTCCTGCT	0.547000													34	113					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51955813	51955813	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:51955813C>G	ENST00000321424.3	-	7	1386	c.1320G>C	c.(1318-1320)ggG>ggC	p.G440G	SIGLEC8_ENST00000340550.5_Silent_p.G347G|SIGLEC8_ENST00000430817.1_Silent_p.G331G	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	440					cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		CTCCTTCCTCCCCTGACGAGG	0.572000													13	61					0	0	1	0	0
SSBP4	170463	broad.mit.edu	37	19	18545055	18545055	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:18545055G>A	ENST00000270061.6	+	18	1377	c.1157G>A	c.(1156-1158)tGa>tAa	p.*386*	SSBP4_ENST00000348495.5_Silent_p.*364*	NM_032627.4	NP_116016.1	Q9BWG4	SSBP4_HUMAN	single stranded DNA binding protein 4	0						nucleus	single-stranded DNA binding			endometrium(2)|kidney(1)|skin(1)	4						ATGAGCGTGTGATGGGGCGGC	0.721000													14	99					0	0	1	0	0
KIAA0586	9786	broad.mit.edu	37	14	58955482	58955482	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:58955482C>G	ENST00000423743.3	+	25	3797	c.3539C>G	c.(3538-3540)tCa>tGa	p.S1180*	KIAA0586_ENST00000261244.5_Nonsense_Mutation_p.S1148*|KIAA0586_ENST00000556134.1_Nonsense_Mutation_p.S1209*|KIAA0586_ENST00000538571.2_3'UTR|KIAA0586_ENST00000354386.6_Nonsense_Mutation_p.S1277*	NM_001244191.1|NM_001244192.1	NP_001231120.1|NP_001231121.1	E9PGW8	E9PGW8_HUMAN	KIAA0586	1148										endometrium(4)|kidney(6)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCTGATTCATCAACACTGGAG	0.478000													14	80					0	0	1	0	0
TRIP10	9322	broad.mit.edu	37	19	6744951	6744951	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:6744951C>T	ENST00000600428.1	+	9	1252	c.606C>T	c.(604-606)ctC>ctT	p.L202L	TRIP10_ENST00000313244.9_Silent_p.L310L|TRIP10_ENST00000596758.1_Silent_p.L310L|TRIP10_ENST00000313285.8_Silent_p.L310L			Q15642	CIP4_HUMAN	thyroid hormone receptor interactor 10	310	Induction of membrane tubulation.				actin cytoskeleton organization|cell communication|endocytosis|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell projection|cytoskeleton|cytosol|Golgi apparatus|lysosome|perinuclear region of cytoplasm|phagocytic cup	GTPase activator activity|identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(1)|large_intestine(1)|liver(2)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	16						GGCCTGAACTCCGAGGCCCGG	0.667000													37	62					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98380186	98380186	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:98380186C>T	ENST00000339364.5	-	12	1983	c.1864G>A	c.(1864-1866)Gtg>Atg	p.V622M	PIK3AP1_ENST00000371110.2_Missense_Mutation_p.V444M|PIK3AP1_ENST00000371109.3_Missense_Mutation_p.V221M	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	622						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		GCCTCATCCACGTTGACAATG	0.522000													44	156					0	0	1	0	0
RRP36	88745	broad.mit.edu	37	6	42996903	42996903	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:42996903G>C	ENST00000244496.5	+	7	727	c.717G>C	c.(715-717)ttG>ttC	p.L239F		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	239					ribosomal small subunit biogenesis|rRNA processing	nucleolus				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						AGAACTTCTTGAGTCGAAAGA	0.498000													53	180					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	93088269	93088269	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:93088269G>C	ENST00000523629.1	-	2	466	c.12C>G	c.(10-12)gtC>gtG	p.V4V	RUNX1T1_ENST00000520724.1_Intron|RUNX1T1_ENST00000265814.3_Silent_p.V4V|RUNX1T1_ENST00000522163.1_5'UTR|RUNX1T1_ENST00000518844.1_5'UTR|RUNX1T1_ENST00000436581.2_Intron|RUNX1T1_ENST00000360348.2_Intron	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	4					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TGTTTCTTTTGACAGATATCA	0.393000													45	231					0	0	1	0	0
BPTF	2186	broad.mit.edu	37	17	65908725	65908725	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:65908725C>T	ENST00000321892.4	+	13	5164	c.5103C>T	c.(5101-5103)gtC>gtT	p.V1701V	BPTF_ENST00000306378.6_Silent_p.V1575V|BPTF_ENST00000424123.3_Silent_p.V1562V|BPTF_ENST00000335221.5_Silent_p.V1701V			Q12830	BPTF_HUMAN	bromodomain PHD finger transcription factor	1701					brain development|chromatin remodeling|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NURF complex	sequence-specific DNA binding|transcription factor binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(23)|ovary(3)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	78	all_cancers(12;6e-11)		BRCA - Breast invasive adenocarcinoma(8;7.48e-08)|Colorectal(3;0.0984)|LUSC - Lung squamous cell carcinoma(166;0.24)			ATGAAAATGTCAATGGAGAAT	0.378000													14	140					0	0	1	0	0
CHD3	1107	broad.mit.edu	37	17	7797908	7797908	+	Silent	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:7797908A>G	ENST00000380358.4	+	8	1429	c.1428A>G	c.(1426-1428)aaA>aaG	p.K476K	CHD3_ENST00000330494.7_Silent_p.K417K|CHD3_ENST00000358181.4_Silent_p.K417K	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	417					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CAGAGGGCAAATGGAGCTGCC	0.567000													34	75					0	0	1	0	0
ITGAL	3683	broad.mit.edu	37	16	30500431	30500431	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:30500431C>T	ENST00000356798.6	+	10	1215	c.1035C>T	c.(1033-1035)ttC>ttT	p.F345F	RP11-297C4.2_ENST00000569459.1_RNA|ITGAL_ENST00000568012.1_3'UTR|ITGAL_ENST00000433423.2_Intron|ITGAL_ENST00000358164.5_Silent_p.F262F	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	345					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TGACTTCCTTCAACATGGAGC	0.562000													13	105					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48826610	48826610	+	Nonsense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:48826610C>A	ENST00000314191.2	-	24	2688	c.2632G>T	c.(2632-2634)Gag>Tag	p.E878*	PRKDC_ENST00000338368.3_Nonsense_Mutation_p.E878*|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	878					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TTCATCATCTCATCTGAGGAC	0.383000								Non-homologous end-joining					40	82					1.62957e-23	1.84245e-23	1	1	0
DNM1	1759	broad.mit.edu	37	9	130965893	130965893	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:130965893C>G	ENST00000341179.7	+	1	236	c.144C>G	c.(142-144)ctC>ctG	p.L48L	DNM1_ENST00000372923.3_Silent_p.L48L|DNM1_ENST00000393594.3_Silent_p.L48L|DNM1_ENST00000475805.1_Silent_p.L48L|DNM1_ENST00000486160.1_Silent_p.L48L|CIZ1_ENST00000372948.3_Intron|CIZ1_ENST00000393608.1_Intron	NM_001005336.1	NP_001005336.1	Q05193	DYN1_HUMAN	dynamin 1	48					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(15)|lung(6)|ovary(2)|urinary_tract(2)	32						GCTCGGTGCTCGAGAATTTCG	0.731000													4	22					0	0	1	0	0
HAUS3	79441	broad.mit.edu	37	4	2242524	2242524	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:2242524C>T	ENST00000243706.4	-	2	379	c.150G>A	c.(148-150)caG>caA	p.Q50Q	POLN_ENST00000511885.2_Intron|POLN_ENST00000515357.1_Intron|HAUS3_ENST00000506763.1_Silent_p.Q50Q|HAUS3_ENST00000443786.2_Silent_p.Q50Q	NM_024511.5	NP_078787.2	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	50					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				breast(3)|endometrium(1)|large_intestine(7)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						ACAACACGTTCTGTTCATTCA	0.413000													33	108					0	0	1	0	0
BRWD1	54014	broad.mit.edu	37	21	40569067	40569067	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr21:40569067C>G	ENST00000342449.3	-	41	6006	c.5928G>C	c.(5926-5928)ttG>ttC	p.L1976F	BRWD1_ENST00000333229.2_Missense_Mutation_p.L1976F|BRWD1_ENST00000380800.3_Missense_Mutation_p.L1976F	NM_033656.3	NP_387505.1	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1976					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				cervix(2)|endometrium(6)|kidney(8)|large_intestine(14)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(7)|urinary_tract(2)	58		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				CACAATCACTCAATTTCTTCT	0.413000													23	133					0	0	1	0	0
SCAMP2	10066	broad.mit.edu	37	15	75137884	75137884	+	Nonsense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:75137884G>C	ENST00000268099.9	-	8	894	c.785C>G	c.(784-786)tCa>tGa	p.S262*		NM_005697.3	NP_005688.2	O15127	SCAM2_HUMAN	secretory carrier membrane protein 2	262					post-Golgi vesicle-mediated transport|protein transport	integral to membrane|nucleus|recycling endosome membrane|trans-Golgi network membrane	protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	9						CATGATGACTGATATGGCCAG	0.557000													95	166					0	0	1	0	0
NIPBL	25836	broad.mit.edu	37	5	36985131	36985131	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:36985131G>A	ENST00000282516.8	+	10	2348	c.1849G>A	c.(1849-1851)Gaa>Aaa	p.E617K	NIPBL_ENST00000448238.2_Missense_Mutation_p.E617K|NIPBL_ENST00000504430.1_3'UTR	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	617					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GAAACAAAGTGAAAGTAGATT	0.343000													18	58					0	0	1	0	0
ASIC3	9311	broad.mit.edu	37	7	150748966	150748966	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:150748966C>A	ENST00000357922.4	+	7	1878	c.1284C>A	c.(1282-1284)gcC>gcA	p.A428A	ASIC3_ENST00000349064.5_Silent_p.A428A|ASIC3_ENST00000297512.8_Silent_p.A428A	NM_020322.3	NP_064718.1	Q9UHC3	ACCN3_HUMAN	acid-sensing (proton-gated) ion channel 3	428					sensory perception|signal transduction	cytoplasm|integral to plasma membrane	ligand-gated sodium channel activity										AGAAGAAGGCCTATGAGATGT	0.587000													5	104					1	1	1	1	0
TRIO	7204	broad.mit.edu	37	5	14474147	14474147	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:14474147G>C	ENST00000344204.4	+	40	6048	c.6024G>C	c.(6022-6024)atG>atC	p.M2008I	TRIO_ENST00000537187.1_Missense_Mutation_p.M2008I	NM_007118.2	NP_009049.2	O75962	TRIO_HUMAN	trio Rho guanine nucleotide exchange factor	2008	DH 2.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(2)|breast(6)|central_nervous_system(4)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(21)|lung(34)|ovary(4)|prostate(2)|skin(11)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	118	Lung NSC(4;0.000742)					CTGATGACATGAAAGGAAAAG	0.403000													19	117					0	0	1	0	0
PNRC1	10957	broad.mit.edu	37	6	89790788	89790788	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:89790788C>G	ENST00000336032.3	+	1	292	c.175C>G	c.(175-177)Cat>Gat	p.H59D	PNRC1_ENST00000369472.1_Intron	NM_006813.2	NP_006804.1	Q12796	PNRC1_HUMAN	proline-rich nuclear receptor coactivator 1	59					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(3)	6		all_cancers(76;3.64e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.102)		CTTCCTCCCTCATTTCCTAGG	0.706000										Multiple Myeloma(7;0.094)			18	30					0	0	1	0	0
ZDBF2	57683	broad.mit.edu	37	2	207169995	207169995	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:207169995C>T	ENST00000374423.3	+	5	1129	c.743C>T	c.(742-744)tCa>tTa	p.S248L		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	248							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						GAAACTACTTCATTTTCGTAT	0.363000													8	35					0	0	1	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73316167	73316167	+	Silent	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:73316167G>C	ENST00000258098.6	-	2	948	c.708C>G	c.(706-708)ctC>ctG	p.L236L	RAB11FIP5_ENST00000493523.2_5'UTR	NM_015470.2	NP_056285.1	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)	236					protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding			biliary_tract(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	23						GCTTGTTGCGGAGGAAGAAGC	0.617000													32	111					0	0	1	0	0
SIGIRR	59307	broad.mit.edu	37	11	407817	407817	+	Splice_Site	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:407817C>T	ENST00000431843.2	-	5	787	c.481_splice	c.e5+1	p.D161_splice	SIGIRR_ENST00000382520.2_Splice_Site_p.D161_splice|SIGIRR_ENST00000397632.3_Splice_Site_p.D161_splice|SIGIRR_ENST00000332725.3_Splice_Site_p.D161_splice|SIGIRR_ENST00000529486.1_5'UTR|SIGIRR_ENST00000531205.1_Splice_Site_p.D161_splice	NM_001135054.1	NP_001128526.1	Q6IA17	SIGIR_HUMAN	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	161					acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity			cervix(2)|endometrium(1)|liver(1)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	13		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CCCCACGCACCGTTTATCTCC	0.687000													37	124					0	0	1	0	0
ZNF45	7596	broad.mit.edu	37	19	44418201	44418201	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:44418201G>A	ENST00000269973.5	-	10	2477	c.1387C>T	c.(1387-1389)Caa>Taa	p.Q463*	ZNF45_ENST00000589703.1_Nonsense_Mutation_p.Q463*|RP11-15A1.2_ENST00000586247.1_RNA	NM_003425.3	NP_003416.1	Q02386	ZNF45_HUMAN	zinc finger protein 45	463					multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	17						TGGCCTCTTTGATGGGCCAGA	0.463000													26	62					0	0	1	0	0
OAS2	4939	broad.mit.edu	37	12	113447035	113447035	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:113447035G>T	ENST00000392583.2	+	10	2246	c.2039G>T	c.(2038-2040)tGg>tTg	p.W680L	OAS2_ENST00000342315.4_Missense_Mutation_p.W680L|RP1-71H24.1_ENST00000552784.1_RNA	NM_002535.2	NP_002526.2	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2, 69/71kDa	680	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			NS(1)|breast(2)|endometrium(4)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	28						ATACCACCTTGGAAAGTGCCG	0.473000													51	365					1.27862e-28	1.45927e-28	1	1	0
STX11	8676	broad.mit.edu	37	6	144508448	144508448	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:144508448C>T	ENST00000367568.4	+	2	867	c.684C>T	c.(682-684)ttC>ttT	p.F228F		NM_003764.3	NP_003755.2	O75558	STX11_HUMAN	syntaxin 11	228	t-SNARE coiled-coil homology.				cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|skin(1)	12				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		ACGAGCTCTTCTTGCAGATGG	0.657000									Familial Hemophagocytic Lymphohistiocytosis				23	50					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86057636	86057636	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:86057636G>A	ENST00000414626.2	+	18	3818	c.2929G>A	c.(2929-2931)Gaa>Aaa	p.E977K	LRRCC1_ENST00000360375.3_Missense_Mutation_p.E997K			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	997					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						CCATCAAATTGAAAAAGAAAT	0.264000													7	45					0	0	1	0	0
TMC4	147798	broad.mit.edu	37	19	54667500	54667500	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:54667500C>T	ENST00000376591.4	-	8	1382	c.1251G>A	c.(1249-1251)ctG>ctA	p.L417L	TMC4_ENST00000301187.4_Silent_p.L411L	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	417						integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					TGTAGCCCTCCAGTGGAGCAA	0.567000											OREG0003641	type=REGULATORY REGION|Gene=AK124406|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	35	141					0	0	1	0	0
ESPN	83715	broad.mit.edu	37	1	6504635	6504635	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:6504635C>G	ENST00000377828.1	+	6	1253	c.1085C>G	c.(1084-1086)tCg>tGg	p.S362W	RP1-202O8.2_ENST00000419034.1_RNA	NM_031475.2	NP_113663.2	B1AK53	ESPN_HUMAN	espin	362					sensory perception of sound	brush border|cytoplasm|filamentous actin|stereocilium	actin filament binding|SH3 domain binding			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)	17	Ovarian(185;0.0386)|all_lung(157;0.154)	all_cancers(23;3.6e-37)|all_epithelial(116;2.56e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|all_hematologic(16;6.92e-06)|Colorectal(325;4.47e-05)|Acute lymphoblastic leukemia(12;4.92e-05)|Breast(487;7.61e-05)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)		Epithelial(90;1.82e-35)|GBM - Glioblastoma multiforme(13;3e-28)|Kidney(185;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(229;5.63e-08)|Colorectal(212;7e-08)|COAD - Colon adenocarcinoma(227;1.41e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000109)|STAD - Stomach adenocarcinoma(132;0.00167)|Lung(427;0.0108)|LUSC - Lung squamous cell carcinoma(448;0.0253)|READ - Rectum adenocarcinoma(331;0.0419)		ACCACGGTGTCGGTCCAGCCG	0.617000													43	150					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102064113	102064113	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:102064113C>G	ENST00000549145.1	+	24	2657	c.2557C>G	c.(2557-2559)Cgc>Ggc	p.R853G	MYBPC1_ENST00000361466.2_Missense_Mutation_p.R847G|MYBPC1_ENST00000361685.2_Missense_Mutation_p.R847G|MYBPC1_ENST00000536007.1_Missense_Mutation_p.R803G|MYBPC1_ENST00000553190.1_Missense_Mutation_p.R822G|MYBPC1_ENST00000392934.3_Missense_Mutation_p.R809G|MYBPC1_ENST00000360610.2_Missense_Mutation_p.R840G|MYBPC1_ENST00000441232.1_Missense_Mutation_p.R840G|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000452455.2_Missense_Mutation_p.R840G|MYBPC1_ENST00000547509.1_Missense_Mutation_p.R808G|MYBPC1_ENST00000551300.1_Missense_Mutation_p.R723G|MYBPC1_ENST00000541119.1_Missense_Mutation_p.R810G|MYBPC1_ENST00000550270.1_Missense_Mutation_p.R840G|MYBPC1_ENST00000547405.1_Missense_Mutation_p.R796G|MYBPC1_ENST00000545503.2_Missense_Mutation_p.R822G			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	840	Ig-like C2-type 6.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						TCCAAAGATTCGCATTCCAAG	0.428000													61	221					0	0	1	0	0
USP9Y	8287	broad.mit.edu	37	Y	14838715	14838715	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrY:14838715C>T	ENST00000338981.3	+	7	1591	c.646C>T	c.(646-648)Cga>Tga	p.R216*	USP9Y_ENST00000426564.2_3'UTR	NM_004654.3	NP_004645.2	O00507	USP9Y_HUMAN	ubiquitin specific peptidase 9, Y-linked	216					BMP signaling pathway|protein deubiquitination|spermatogenesis|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			kidney(1)|large_intestine(8)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TTCAGATCCTCGATCACCAAA	0.348000													36	83					0	0	1	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555158	44555158	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:44555158G>A	ENST00000330682.2	-	1	1291	c.1056C>T	c.(1054-1056)ctC>ctT	p.L352L	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	352	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding	p.L352L(1)		NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						CCACGTCGCCGAGGGCGTCCG	0.652000													23	1982					0	0	1	0	0
GORAB	92344	broad.mit.edu	37	1	170521271	170521271	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:170521271G>A	ENST00000367763.3	+	5	873	c.853G>A	c.(853-855)Gag>Aag	p.E285K		NM_152281.2	NP_689494.2	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting	285	Necessary for interaction with RCHY1.					Golgi apparatus|nucleus				endometrium(2)|large_intestine(3)|liver(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	17						ACAGCAAAATGAGCTCCGAAA	0.458000													16	92					0	0	1	0	0
THOP1	7064	broad.mit.edu	37	19	2799701	2799701	+	Silent	SNP	C	C	T	rs149899689		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:2799701C>T	ENST00000307741.6	+	5	704	c.501C>T	c.(499-501)atC>atT	p.I167I	THOP1_ENST00000586677.1_Silent_p.I46I	NM_003249.3	NP_003240.1	P52888	THOP1_HUMAN	thimet oligopeptidase 1	167					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|lung(8)|ovary(2)|skin(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAAACGCATCAAGAAGAAGC	0.622000													39	87					0	0	1	0	0
NUCB2	4925	broad.mit.edu	37	11	17351722	17351722	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:17351722G>A	ENST00000529010.1	+	12	1270	c.1051G>A	c.(1051-1053)Gaa>Aaa	p.E351K	NUCB2_ENST00000323688.6_Missense_Mutation_p.E351K|NUCB2_ENST00000458064.2_Missense_Mutation_p.E321K	NM_005013.2	NP_005004.1	P80303	NUCB2_HUMAN	nucleobindin 2	351	Binds to necdin (By similarity).					cytosol|ER-Golgi intermediate compartment|extracellular space|Golgi apparatus|plasma membrane	calcium ion binding|DNA binding			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14						AAAAGAATATGAAAATATTAT	0.323000													6	14					0	0	1	0	0
TRERF1	55809	broad.mit.edu	37	6	42196193	42196193	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:42196193C>T	ENST00000541110.1	-	18	4121	c.3553G>A	c.(3553-3555)Gac>Aac	p.D1185N	TRERF1_ENST00000354325.2_Missense_Mutation_p.D1082N|TRERF1_ENST00000372917.4_Missense_Mutation_p.D1094N|TRERF1_ENST00000372922.4_Missense_Mutation_p.D1165N|TRERF1_ENST00000340840.2_Missense_Mutation_p.D1094N			Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	1165	Interacts with CREBBP.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding	p.D1165N(1)		breast(1)|central_nervous_system(2)|endometrium(7)|kidney(1)|large_intestine(12)|lung(13)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(2)	45	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TGGACGACGTCGTCGTCGAGG	0.582000													51	206					0	0	1	0	0
GAL3ST3	89792	broad.mit.edu	37	11	65810468	65810468	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:65810468G>C	ENST00000312006.4	-	3	1087	c.806C>G	c.(805-807)gCg>gGg	p.A269G	GAL3ST3_ENST00000527878.1_Missense_Mutation_p.A269G	NM_033036.2	NP_149025.1	Q96A11	G3ST3_HUMAN	galactose-3-O-sulfotransferase 3	269					monosaccharide metabolic process|oligosaccharide metabolic process|poly-N-acetyllactosamine metabolic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi cisterna membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|carbohydrate binding|galactosylceramide sulfotransferase activity|proteoglycan sulfotransferase activity			kidney(1)|lung(9)|ovary(2)|skin(2)	14						GGCGGCGCGCGCGTTGAGCTT	0.711000													13	16					0	0	1	0	0
EPHB4	2050	broad.mit.edu	37	7	100420125	100420125	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:100420125G>A	ENST00000358173.3	-	4	1044	c.576C>T	c.(574-576)ctC>ctT	p.L192L	EPHB4_ENST00000360620.3_Silent_p.L192L|EPHB4_ENST00000477446.1_5'UTR	NM_004444.4	NP_004435.3	P54760	EPHB4_HUMAN	EPH receptor B4	192	Cys-rich.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(7)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(3)	47	Lung NSC(181;0.041)|all_lung(186;0.0581)					TTTTGTAGAAGAGGTGCAGGG	0.617000													20	45					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176637183	176637183	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:176637183G>A	ENST00000439151.2	+	5	1828	c.1783G>A	c.(1783-1785)Gag>Aag	p.E595K	NSD1_ENST00000361032.4_Missense_Mutation_p.E492K|NSD1_ENST00000354179.4_Missense_Mutation_p.E326K|NSD1_ENST00000347982.4_Missense_Mutation_p.E326K	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	595					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		GGGCTTGCCTGAGGGTGCTTT	0.438000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			33	87					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171236773	171236773	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:171236773C>A	ENST00000354841.4	+	2	355	c.224C>A	c.(223-225)cCa>cAa	p.P75Q	FMO1_ENST00000402921.2_Intron|FMO1_ENST00000367750.3_Missense_Mutation_p.P75Q|FMO1_ENST00000469112.1_3'UTR			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	75					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTTCCATTCCCAGAAGATTAT	0.398000													51	99					3.4597e-24	3.92387e-24	1	1	0
PRMT1	3276	broad.mit.edu	37	19	50189350	50189350	+	Splice_Site	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:50189350G>C	ENST00000532489.1	+	9	1128	c.621_splice	c.e9-1	p.E208_splice	PRMT1_ENST00000391851.4_Splice_Site_p.E236_splice|PRMT1_ENST00000454376.2_Splice_Site_p.E254_splice			Q8WUW5	Q8WUW5_HUMAN	protein arginine methyltransferase 1	235						cytoplasm	protein methyltransferase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(4)|ovary(2)	12		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00103)|GBM - Glioblastoma multiforme(134;0.012)		TGTCCTGCAGGAGGTGGACAT	0.617000													20	65					0	0	1	0	0
CD47	961	broad.mit.edu	37	3	107778371	107778371	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:107778371C>A	ENST00000355354.7	-	5	735	c.619G>T	c.(619-621)Gct>Tct	p.A207S	CD47_ENST00000361309.5_Missense_Mutation_p.A207S	NM_198793.2	NP_942088.1	Q08722	CD47_HUMAN	CD47 molecule	207					blood coagulation|cell adhesion|cell junction assembly|integrin-mediated signaling pathway|leukocyte migration|positive regulation of cell proliferation|positive regulation of cell-cell adhesion|positive regulation of T cell activation	integral to plasma membrane	protein binding|thrombospondin receptor activity			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	9			OV - Ovarian serous cystadenocarcinoma(3;0.0191)|Epithelial(53;0.118)			AGGCCAGTAGCATTCTTTAAT	0.279000													28	48					2.47511e-08	2.60783e-08	1	1	0
RGPD4	285190	broad.mit.edu	37	2	108488526	108488526	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:108488526G>T	ENST00000408999.3	+	20	4143	c.4066G>T	c.(4066-4068)Gtt>Ttt	p.V1356F	RGPD4_ENST00000354986.4_Missense_Mutation_p.V1356F	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1356	RanBD1 2.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						AAATGAAAAAGTTGTTTTTAG	0.363000													89	466					2.84844e-50	3.30273e-50	1	1	0
CGREF1	10669	broad.mit.edu	37	2	27325437	27325437	+	Translation_Start_Site	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:27325437G>C	ENST00000452318.2	-	0	452				CGREF1_ENST00000260595.5_Missense_Mutation_p.Q35E|CGREF1_ENST00000402394.1_Missense_Mutation_p.Q35E|CGREF1_ENST00000405600.1_Missense_Mutation_p.Q35E|CGREF1_ENST00000404694.3_Missense_Mutation_p.Q157E|CGREF1_ENST00000312734.4_Missense_Mutation_p.Q35E|CGREF1_ENST00000402550.1_Missense_Mutation_p.Q35E	NM_001166241.1	NP_001159713.1	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1						cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			kidney(1)|lung(4)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCAGGAGCTGATGCTGCACT	0.652000													27	103					0	0	1	0	0
STXBP6	29091	broad.mit.edu	37	14	25288390	25288390	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:25288390G>A	ENST00000323944.5	-	5	913	c.462C>T	c.(460-462)atC>atT	p.I154I	STXBP6_ENST00000396700.1_Silent_p.I154I|STXBP6_ENST00000548369.1_Silent_p.I52I|STXBP6_ENST00000548724.1_Silent_p.I154I|STXBP6_ENST00000419632.2_Silent_p.I154I|STXBP6_ENST00000358326.2_Silent_p.I154I|STXBP6_ENST00000546511.1_Silent_p.I154I|STXBP6_ENST00000550887.1_Silent_p.I154I			Q8NFX7	STXB6_HUMAN	syntaxin binding protein 6 (amisyn)	154	v-SNARE coiled-coil homology.				vesicle-mediated transport	cytoplasm|integral to membrane				central_nervous_system(2)|endometrium(2)|large_intestine(3)	7				GBM - Glioblastoma multiforme(265;0.0296)		CTGAATGGAGGATGCTGTTTC	0.567000													41	165					0	0	1	0	0
SNHG7	84973	broad.mit.edu	37	9	139621406	139621406	+	RNA	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:139621406G>A	ENST00000414282.1	-	0	345				SNHG7_ENST00000447221.1_RNA|SNHG7_ENST00000416970.1_RNA																							ACACAAGACCGACTGGTCCCT	0.502000											OREG0019621	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	27					0	0	1	0	0
UGT8	7368	broad.mit.edu	37	4	115544150	115544150	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:115544150C>A	ENST00000310836.6	+	2	636	c.114C>A	c.(112-114)ttC>ttA	p.F38L	UGT8_ENST00000394511.3_Missense_Mutation_p.F38L	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	38					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TGTACATTTTCAAGACGCTAG	0.493000													16	58					0.00316338	0.00320303	1	1	0
MFF	56947	broad.mit.edu	37	2	228197302	228197302	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:228197302G>A	ENST00000353339.3	+	5	868	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	MFF_ENST00000409565.1_Missense_Mutation_p.E117K|MFF_ENST00000354503.6_Missense_Mutation_p.E117K|MFF_ENST00000392059.1_Missense_Mutation_p.E143K|MFF_ENST00000337110.7_Missense_Mutation_p.E117K|MFF_ENST00000409616.1_Missense_Mutation_p.E117K|MFF_ENST00000476924.1_3'UTR|MFF_ENST00000304593.9_Missense_Mutation_p.E117K|MFF_ENST00000349901.7_Missense_Mutation_p.E117K|MFF_ENST00000524634.1_5'UTR	NM_001277061.1	NP_001263990.1	Q9GZY8	MFF_HUMAN	mitochondrial fission factor	143						integral to membrane|mitochondrial outer membrane				breast(3)|endometrium(2)|kidney(3)|large_intestine(7)|lung(4)|stomach(2)	21						TCAAAATGAAGAAGTAAGTAG	0.383000													81	387					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242277289	242277289	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:242277289C>G	ENST00000442594.2	-	8	1206	c.697G>C	c.(697-699)Gac>Cac	p.D233H	PLD5_ENST00000427495.1_Missense_Mutation_p.D263H|PLD5_ENST00000536534.1_Missense_Mutation_p.D325H	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	325	PLD phosphodiesterase 1.					integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			GCATCTATGTCAAAACTTCTG	0.413000													18	79					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	40996003	40996003	+	Missense_Mutation	SNP	A	A	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:40996003A>T	ENST00000352632.3	+	4	429	c.343A>T	c.(343-345)Atg>Ttg	p.M115L	SPTBN4_ENST00000595535.1_Missense_Mutation_p.M115L|SPTBN4_ENST00000338932.3_Missense_Mutation_p.M115L|SPTBN4_ENST00000344104.3_Missense_Mutation_p.M115L|SPTBN4_ENST00000598249.1_Missense_Mutation_p.M115L			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	115	Actin-binding.|CH 1.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCGCGGCCGCATGCGGATCCA	0.662000													14	33					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55592849	55592849	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:55592849G>A	ENST00000201647.6	+	8	819	c.763G>A	c.(763-765)Gag>Aag	p.E255K	EPS8L1_ENST00000245618.5_Missense_Mutation_p.E128K|EPS8L1_ENST00000540810.1_Missense_Mutation_p.E191K|EPS8L1_ENST00000588359.1_Intron|EPS8L1_ENST00000586329.1_Missense_Mutation_p.E237K|EPS8L1_ENST00000592824.1_3'UTR	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	255						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		TCTGCAGGCGGAGCGGGAAGT	0.746000													3	16					0	0	1	0	0
ZNF135	7694	broad.mit.edu	37	19	58578399	58578399	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:58578399G>A	ENST00000506786.1	+	5	975	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	ZNF135_ENST00000439855.2_Missense_Mutation_p.E183K|ZNF135_ENST00000511556.1_Missense_Mutation_p.E195K|ZNF135_ENST00000359978.6_Missense_Mutation_p.E195K|ZNF135_ENST00000313434.5_Missense_Mutation_p.E183K|ZNF135_ENST00000401053.4_Missense_Mutation_p.E207K			B4DHH9	B4DHH9_HUMAN	zinc finger protein 135	195					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(26)|ovary(1)|skin(1)|urinary_tract(1)	41		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0161)		AATGACTCCTGAAAGACAAAG	0.478000													21	74					0	0	1	0	0
ZNF879	345462	broad.mit.edu	37	5	178454577	178454577	+	Missense_Mutation	SNP	A	A	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:178454577A>T	ENST00000444149.2	+	3	325	c.137A>T	c.(136-138)aAc>aTc	p.N46I	ZNF879_ENST00000519896.1_Missense_Mutation_p.E57D	NM_001136116.1	NP_001129588.1	B4DU55	ZN879_HUMAN	zinc finger protein 879	46	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|pancreas(1)|stomach(1)	7						ATGCTGGAGAACTACAGCATC	0.572000													4	35					0	0	1	0	0
PPFIBP1	8496	broad.mit.edu	37	12	27845589	27845589	+	Splice_Site	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:27845589G>T	ENST00000318304.8	+	28	3232	c.2949_splice	c.e28+1	p.T983_splice	PPFIBP1_ENST00000542629.1_Splice_Site_p.T952_splice|PPFIBP1_ENST00000537927.1_Splice_Site_p.T830_splice|PPFIBP1_ENST00000228425.6_Splice_Site_p.T977_splice	NM_001198916.1|NM_177444.2	NP_001185845.1|NP_803193.2	Q86W92	LIPB1_HUMAN	PTPRF interacting protein, binding protein 1 (liprin beta 1)	983					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(13)|prostate(2)|skin(1)	32	Lung SC(9;0.0873)					ACAATCTGACGGTGAGTTTGT	0.383000													4	178					1	1	1	1	0
B2M	567	broad.mit.edu	37	15	45007819	45007819	+	Missense_Mutation	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:45007819A>G	ENST00000558401.1	+	2	336	c.266A>G	c.(265-267)gAa>gGa	p.E89G	B2M_ENST00000544417.1_Missense_Mutation_p.E89G|B2M_ENST00000559220.1_Intron|B2M_ENST00000559916.1_Missense_Mutation_p.E89G	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	89	Ig-like C1-type.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding			breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		TACTACACTGAATTCACCCCC	0.418000													50	68					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	40996002	40996002	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:40996002C>A	ENST00000352632.3	+	4	428	c.342C>A	c.(340-342)cgC>cgA	p.R114R	SPTBN4_ENST00000595535.1_Silent_p.R114R|SPTBN4_ENST00000338932.3_Silent_p.R114R|SPTBN4_ENST00000344104.3_Silent_p.R114R|SPTBN4_ENST00000598249.1_Silent_p.R114R			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	114	Actin-binding.|CH 1.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CGCGCGGCCGCATGCGGATCC	0.657000													13	33					0.00316338	0.00320303	1	1	0
BPHL	670	broad.mit.edu	37	6	3127631	3127631	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:3127631G>C	ENST00000380368.2	+	4	960	c.316G>C	c.(316-318)Gat>Cat	p.D106H	BPHL_ENST00000380379.5_Missense_Mutation_p.D123H|BPHL_ENST00000434640.1_Missense_Mutation_p.D106H|BPHL_ENST00000380375.3_Missense_Mutation_p.D106H			Q86WA6	BPHL_HUMAN	biphenyl hydrolase-like (serine hydrolase)	123					cellular amino acid metabolic process|response to toxin	mitochondrion	hydrolase activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(6)	13	Ovarian(93;0.0386)	all_hematologic(90;0.108)				AGATGCTGTTGATTTGATGAA	0.478000													39	123					0	0	1	0	0
JPH2	57158	broad.mit.edu	37	20	42788652	42788652	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:42788652C>T	ENST00000372980.3	-	2	1647	c.775G>A	c.(775-777)Gac>Aac	p.D259N		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	259					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			GACGCGGCGTCGCTGGCGCCC	0.711000													3	14					0	0	1	0	0
RFC4	5984	broad.mit.edu	37	3	186507953	186507953	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:186507953G>C	ENST00000392481.2	-	10	1255	c.974C>G	c.(973-975)tCt>tGt	p.S325C	RFC4_ENST00000433496.1_Missense_Mutation_p.S298C|RFC4_ENST00000296273.2_Missense_Mutation_p.S325C	NM_181573.2	NP_853551.1	P35249	RFC4_HUMAN	replication factor C (activator 1) 4, 37kDa	325					cell cycle checkpoint|DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|protein binding			breast(3)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26	all_cancers(143;2.92e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)	GBM - Glioblastoma multiforme(93;0.0739)		TGTGATAATAGACTTCTGTTT	0.348000													24	109					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34962790	34962790	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:34962790G>T	ENST00000329357.5	+	1	1878	c.1842G>T	c.(1840-1842)aaG>aaT	p.K614N		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	614										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						TTGCCAAGAAGGGATGGACTT	0.418000													81	74					8.6838e-40	1.00208e-39	1	1	0
ZNF493	284443	broad.mit.edu	37	19	21606115	21606115	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:21606115C>T	ENST00000392288.2	+	4	763	c.654C>T	c.(652-654)gcC>gcT	p.A218A	CTD-2561J22.3_ENST00000600810.1_Intron|ZNF493_ENST00000355504.4_Silent_p.A90A	NM_001076678.2	NP_001070146.1	Q6ZR52	ZN493_HUMAN	zinc finger protein 493	90					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	30						GTGGCAAAGCCTTTATCTGGT	0.363000													41	56					0	0	1	0	0
H6PD	9563	broad.mit.edu	37	1	9324757	9324757	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:9324757C>A	ENST00000377403.2	+	5	2507	c.2205C>A	c.(2203-2205)ctC>ctA	p.L735L	H6PD_ENST00000602477.1_Silent_p.L746L	NM_004285.3	NP_004276.2	O95479	G6PE_HUMAN	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	735	6-phosphogluconolactonase.					endoplasmic reticulum lumen	6-phosphogluconolactonase activity|glucose 1-dehydrogenase|glucose-6-phosphate dehydrogenase activity|NADP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)	23	all_lung(157;0.23)	all_epithelial(116;1.28e-19)|all_lung(118;5.22e-06)|Lung NSC(185;1.98e-05)|Renal(390;0.000147)|Breast(348;0.00109)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;1.88e-07)|COAD - Colon adenocarcinoma(227;7.47e-05)|Kidney(185;0.000244)|KIRC - Kidney renal clear cell carcinoma(229;0.000905)|STAD - Stomach adenocarcinoma(132;0.00176)|BRCA - Breast invasive adenocarcinoma(304;0.00183)|READ - Rectum adenocarcinoma(331;0.0419)	NADH(DB00157)	GCCTGCCTCTCATCAACCGCG	0.642000													16	69					6.72482e-11	7.23217e-11	1	1	0
ATXN7L1	222255	broad.mit.edu	37	7	105429084	105429084	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:105429084C>G	ENST00000419735.3	-	3	366	c.321G>C	c.(319-321)caG>caC	p.Q107H	ATXN7L1_ENST00000478915.1_Missense_Mutation_p.Q56H|ATXN7L1_ENST00000318724.4_Missense_Mutation_p.Q107H	NM_020725.1	NP_065776.1	Q9ULK2	AT7L1_HUMAN	ataxin 7-like 1	107										endometrium(1)|large_intestine(4)|lung(5)	10						GCTTGACGACCTGGTTACAGG	0.547000													49	53					0	0	1	0	0
IL18RAP	8807	broad.mit.edu	37	2	103061710	103061710	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:103061710C>G	ENST00000264260.2	+	9	1571	c.982C>G	c.(982-984)Cag>Gag	p.Q328E	IL18RAP_ENST00000409369.1_Missense_Mutation_p.Q186E	NM_003853.2	NP_003844.1	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	328	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(5)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(4)	37						AAAAGTCACTCAGCGTGATCT	0.403000													15	115					0	0	1	0	0
TTC27	55622	broad.mit.edu	37	2	32958898	32958898	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:32958898C>T	ENST00000317907.4	+	11	1468	c.1237C>T	c.(1237-1239)Ctt>Ttt	p.L413F		NM_001193509.1|NM_017735.4	NP_001180438.1|NP_060205.3	Q6P3X3	TTC27_HUMAN	tetratricopeptide repeat domain 27	413							protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	38						CTTTAAGGCTCTTGCAGACCA	0.323000													17	58					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100674431	100674431	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:100674431G>C	ENST00000306151.4	+	2	177	c.113G>C	c.(112-114)gGa>gCa	p.G38A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	38						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTGTGGGATGGAGGAGGGTGC	0.517000													47	165					0	0	1	0	0
NXF2B	728343	broad.mit.edu	37	X	101615556	101615556	+	Missense_Mutation	SNP	T	T	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:101615556T>A	ENST00000457521.2	-	34	3718	c.1847A>T	c.(1846-1848)aAg>aTg	p.K616M	NXF2B_ENST00000372752.1_3'UTR|NXF2B_ENST00000372749.1_Missense_Mutation_p.K616M|NXF2B_ENST00000412230.2_Missense_Mutation_p.K616M|NXF2B_ENST00000372750.1_Missense_Mutation_p.K616M					nuclear RNA export factor 2B											breast(1)|kidney(1)|lung(4)|ovary(1)	7						CGCGGGGATCTTGCCCTCGGT	0.507000													17	79					0	0	1	0	0
TPP2	7174	broad.mit.edu	37	13	103288020	103288020	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:103288020G>A	ENST00000376052.3	+	12	1493	c.1477G>A	c.(1477-1479)Gaa>Aaa	p.E493K	TPP2_ENST00000376065.4_Missense_Mutation_p.E493K			P29144	TPP2_HUMAN	tripeptidyl peptidase II	493					proteolysis	cytoplasm|nucleus	aminopeptidase activity|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	52	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGACAATATAGAAGTATTTGC	0.333000													27	64					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21233601	21233601	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:21233601C>T	ENST00000233242.1	-	26	6266	c.6139G>A	c.(6139-6141)Gag>Aag	p.E2047K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2047	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGGGCTTCTCAACGGCATCT	0.388000													33	110					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382542	22382542	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:22382542C>G	ENST00000328795.4	+	1	161	c.70C>G	c.(70-72)Cag>Gag	p.Q24E	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	24					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCAAGATATTCAGCTCTTGGT	0.393000													44	369					0	0	1	0	0
CBS	875	broad.mit.edu	37	21	44486390	44486390	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr21:44486390G>A	ENST00000398165.3	-	5	673	c.414C>T	c.(412-414)ccC>ccT	p.P138P	CBS_ENST00000398158.1_Silent_p.P138P|CBS_ENST00000359624.3_Silent_p.P138P|CBS_ENST00000544202.1_Silent_p.P50P|CBS_ENST00000398168.1_Silent_p.P138P|CBS_ENST00000470912.1_5'UTR|CBS_ENST00000352178.5_Silent_p.P138P	NM_000071.2	NP_000062.1	P35520	CBS_HUMAN	cystathionine-beta-synthase	138					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(8)	17					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	TCGTGTCCCCGGGCTTCAGCG	0.667000													33	89					0	0	1	0	0
C9orf50	375759	broad.mit.edu	37	9	132375865	132375865	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:132375865C>T	ENST00000372478.4	-	5	1093	c.892G>A	c.(892-894)Gtc>Atc	p.V298I	NTMT1_ENST00000372486.1_Intron	NM_199350.3	NP_955382.3	Q5SZB4	CI050_HUMAN	chromosome 9 open reading frame 50	298										central_nervous_system(1)|endometrium(4)|large_intestine(2)|ovary(1)|skin(1)|urinary_tract(1)	10		Ovarian(14;0.00556)				TTCACAATGACGCTCTGTTGG	0.632000													13	172					0	0	1	0	0
BCRP7	100133163	broad.mit.edu	37	22	18846006	18846006	+	RNA	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:18846006A>G	ENST00000412938.1	+	0	3364																											GCGCAGGCCGACACTCACTGA	0.617000													4	111					0	0	1	0	0
KIAA1468	57614	broad.mit.edu	37	18	59966023	59966023	+	Splice_Site	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:59966023G>T	ENST00000256858.6	+	29	3810	c.3561_splice	c.e29-1	p.V1188_splice	KIAA1468_ENST00000398130.2_Splice_Site_p.V1154_splice			Q9P260	K1468_HUMAN	KIAA1468	1154							binding			autonomic_ganglia(1)|breast(4)|endometrium(4)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47		Colorectal(73;0.186)				TTTTAATCAGGTTATTTTAAG	0.264000													10	26					0.000442599	0.000450028	1	1	0
OR1J2	26740	broad.mit.edu	37	9	125273662	125273662	+	Silent	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:125273662C>G	ENST00000335302.5	+	1	582	c.582C>G	c.(580-582)ctC>ctG	p.L194L		NM_054107.1	NP_473448.1	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J, member 2	194					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						ATATCTTCCTCAATGAGCTGG	0.532000													27	112					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64676250	64676250	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:64676250C>T	ENST00000357395.3	+	103	18793	c.7649C>T	c.(7648-7650)tCa>tTa	p.S2550L	SYNE2_ENST00000554584.1_Missense_Mutation_p.S6127L|SYNE2_ENST00000344113.4_Missense_Mutation_p.S6165L|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000358025.3_Missense_Mutation_p.S6165L|SYNE2_ENST00000394768.2_Missense_Mutation_p.S2550L|SYNE2_ENST00000555022.1_Missense_Mutation_p.S43L|SYNE2_ENST00000554805.1_5'UTR|SYNE2_ENST00000555002.1_Missense_Mutation_p.S2799L			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6165					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCAAATTCCTCAGAGGTGTTG	0.537000													12	57					0	0	1	0	0
MVB12A	93343	broad.mit.edu	37	19	17534379	17534379	+	Nonsense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:17534379C>G	ENST00000528515.1	+	4	413	c.359C>G	c.(358-360)tCa>tGa	p.S120*	MVB12A_ENST00000317040.7_Silent_p.L162L|MVB12A_ENST00000392702.2_Intron|MVB12A_ENST00000529939.1_Silent_p.L162L|MVB12A_ENST00000543795.1_Silent_p.L162L					multivesicular body subunit 12A																		CCCGAGGTCTCAGCCGGGACA	0.657000													19	71					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26586790	26586790	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:26586790C>G	ENST00000436318.2	-	2	830	c.697G>C	c.(697-699)Gaa>Caa	p.E233Q	ANO3_ENST00000531568.1_Intron|ANO3_ENST00000537978.1_Intron|MUC15_ENST00000527569.1_Missense_Mutation_p.E233Q|MUC15_ENST00000281268.8_Missense_Mutation_p.E233Q|MUC15_ENST00000455601.2_Missense_Mutation_p.E206Q|MUC15_ENST00000529533.1_Missense_Mutation_p.E233Q|ANO3_ENST00000256737.3_Intron|ANO3_ENST00000525139.1_Intron			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	206						extracellular region|integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						GTTGTTTTTTCTTGATAAGGG	0.378000													16	93					0	0	1	0	0
MAML1	9794	broad.mit.edu	37	5	179192990	179192990	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:179192990C>T	ENST00000292599.3	+	2	1242	c.979C>T	c.(979-981)Ctg>Ttg	p.L327L	MAML1_ENST00000503050.1_3'UTR	NM_014757.4	NP_055572.1	Q92585	MAML1_HUMAN	mastermind-like 1 (Drosophila)	327					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	36	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCAGACCTTTCTGGGGCCTTC	0.567000													11	76					0	0	1	0	0
SULT1C2	6819	broad.mit.edu	37	2	108921946	108921946	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:108921946G>A	ENST00000326853.5	+	8	1159	c.706G>A	c.(706-708)Gtc>Atc	p.V236I	SULT1C2_ENST00000251481.6_Missense_Mutation_p.V225I|SULT1C2_ENST00000437390.2_Missense_Mutation_p.V239I|SULT1C2_ENST00000409880.1_Missense_Mutation_p.V188I	NM_176825.2	NP_789795.1	O00338	ST1C2_HUMAN	sulfotransferase family, cytosolic, 1C, member 2	225					3'-phosphoadenosine 5'-phosphosulfate metabolic process|amine metabolic process|sulfation|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	sulfotransferase activity			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	20						AGATAAAATTGTCCAGGAGAC	0.423000													17	54					0	0	1	0	0
RGS22	26166	broad.mit.edu	37	8	101076134	101076134	+	Nonsense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:101076134G>A	ENST00000360863.6	-	8	1056	c.862C>T	c.(862-864)Caa>Taa	p.Q288*	RGS22_ENST00000523437.1_Nonsense_Mutation_p.Q276*|RGS22_ENST00000523287.1_Nonsense_Mutation_p.Q107*	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	288					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			AGAAGAGCTTGAGAAGGAGTG	0.353000													43	222					0	0	1	0	0
UBE2E3	10477	broad.mit.edu	37	2	181922511	181922511	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:181922511G>A	ENST00000410062.4	+	4	730	c.337G>A	c.(337-339)Gat>Aat	p.D113N	UBE2E3_ENST00000602837.1_3'UTR|UBE2E3_ENST00000602710.1_Missense_Mutation_p.D113N|UBE2E3_ENST00000392415.2_Missense_Mutation_p.D113N|UBE2E3_ENST00000602959.1_Missense_Mutation_p.D113N	NM_006357.2	NP_006348.1	Q969T4	UB2E3_HUMAN	ubiquitin-conjugating enzyme E2E 3	113					protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|regulation of growth	cytoplasm|nucleolus	ATP binding|protein binding|ubiquitin-protein ligase activity			breast(2)|endometrium(3)|lung(4)|ovary(1)|skin(1)	11						GTTTTTTCTGGATATCACATT	0.358000													64	88					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36212555	36212555	+	Missense_Mutation	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:36212555T>C	ENST00000420124.1	+	3	2306	c.2306T>C	c.(2305-2307)aTg>aCg	p.M769T	WBP7_ENST00000222270.7_Missense_Mutation_p.M769T|KMT2B_ENST00000607650.1_RNA																							CCACAGCAGATGCCTCCCCTG	0.632000													13	22					0	0	1	0	0
ETV3L	440695	broad.mit.edu	37	1	157062633	157062633	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:157062633C>G	ENST00000454449.2	-	5	1178	c.894G>C	c.(892-894)gaG>gaC	p.E298D		NM_001004341.2	NP_001004341.1	Q6ZN32	ETV3L_HUMAN	ets variant 3-like	298						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Hepatocellular(266;0.158)	Prostate(1639;0.184)				GCCAAAGCCTCTCACCCGCAC	0.627000													11	91					0	0	1	0	0
KMT2D	8085	broad.mit.edu	37	12	49420767	49420767	+	Silent	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:49420767C>A	ENST00000301067.7	-	48	14981	c.14982G>T	c.(14980-14982)ctG>ctT	p.L4994L		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TCTGGATGGTCAGCAGCAGCC	0.622000													15	126					2.23348e-06	2.33632e-06	1	1	0
ZC3H14	79882	broad.mit.edu	37	14	89038502	89038502	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:89038502G>T	ENST00000251038.5	+	5	589	c.364G>T	c.(364-366)Gcg>Tcg	p.A122S	ZC3H14_ENST00000393514.5_Missense_Mutation_p.A122S|ZC3H14_ENST00000302216.8_Missense_Mutation_p.A122S|ZC3H14_ENST00000557607.1_5'UTR|ZC3H14_ENST00000359301.3_Missense_Mutation_p.A88S|ZC3H14_ENST00000555755.1_Missense_Mutation_p.A122S|ZC3H14_ENST00000556945.1_Missense_Mutation_p.A122S|ZC3H14_ENST00000336693.4_Missense_Mutation_p.A88S	NM_001160103.1|NM_001160104.1|NM_024824.4	NP_001153575.1|NP_001153576.1|NP_079100.2	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	122						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						CATTCCTAGCGCGAGACCTGA	0.483000													39	103					7.63091e-17	8.41832e-17	1	1	0
SETDB2	83852	broad.mit.edu	37	13	50050665	50050665	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:50050665G>C	ENST00000354234.4	+	6	1265	c.359G>C	c.(358-360)aGa>aCa	p.R120T	SETDB2_ENST00000258672.5_Missense_Mutation_p.R120T|SETDB2_ENST00000317257.8_Missense_Mutation_p.R132T	NM_001160308.1	NP_001153780.1	Q96T68	SETB2_HUMAN	SET domain, bifurcated 2	132					cell division|chromosome segregation|heart looping|left/right axis specification|mitosis|negative regulation of transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone methyltransferase activity (H3-K9 specific)|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	15		Lung NSC(96;0.000408)|Breast(56;0.00131)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.1e-09)		GTAGACTTTAGAGAAAAAGAC	0.323000													18	167					0	0	1	0	0
SRM	6723	broad.mit.edu	37	1	11115022	11115022	+	Silent	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:11115022G>T	ENST00000376957.2	-	7	965	c.885C>A	c.(883-885)cgC>cgA	p.R295R		NM_003132.2	NP_003123.2	P19623	SPEE_HUMAN	spermidine synthase	295					spermidine biosynthetic process	cytosol	protein homodimerization activity|spermidine synthase activity			large_intestine(1)|lung(1)|urinary_tract(1)	3	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.228)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)	S-Adenosylmethionine(DB00118)|Spermine(DB00127)	CACCCACCTTGCGGGCAAACT	0.662000													10	91					1.08611e-07	1.13775e-07	1	1	0
SETBP1	26040	broad.mit.edu	37	18	42531223	42531223	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:42531223G>A	ENST00000282030.5	+	4	2214	c.1918G>A	c.(1918-1920)Gac>Aac	p.D640N		NM_015559.2	NP_056374.2	Q9Y6X0	SETBP_HUMAN	SET binding protein 1	640						nucleus	DNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(20)|lung(47)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	104				Colorectal(1;0.0622)|COAD - Colon adenocarcinoma(74;0.201)		GCCGGGAGAGGACAAACCCAT	0.483000									Schinzel-Giedion syndrome				27	90					0	0	1	0	0
MGAT2	4247	broad.mit.edu	37	14	50088132	50088132	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:50088132G>T	ENST00000305386.2	+	1	644	c.146G>T	c.(145-147)gGt>gTt	p.G49V	RP11-649E7.5_ENST00000555043.1_RNA	NM_002408.3	NP_002399.1	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	49					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)	11	all_epithelial(31;0.0021)|Breast(41;0.0124)					CCCGCGCGGGGTGCCGGCGGC	0.731000													18	27					9.16793e-09	9.67356e-09	1	1	0
TSC2	7249	broad.mit.edu	37	16	2129040	2129040	+	Nonsense_Mutation	SNP	C	C	T	rs137854231		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:2129040C>T	ENST00000219476.3	+	27	3604	c.2974C>T	c.(2974-2976)Cag>Tag	p.Q992*	TSC2_ENST00000439673.2_Nonsense_Mutation_p.Q912*|TSC2_ENST00000382538.6_Nonsense_Mutation_p.Q900*|TSC2_ENST00000353929.4_Nonsense_Mutation_p.Q949*|TSC2_ENST00000350773.4_Nonsense_Mutation_p.Q992*|TSC2_ENST00000401874.2_Nonsense_Mutation_p.Q948*|TSC2_ENST00000568366.1_3'UTR|TSC2_ENST00000568454.1_Nonsense_Mutation_p.Q959*	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	992					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				CAGCAGGATACAGACGTCCCT	0.622000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				36	160					0	0	1	0	0
ZNRF4	148066	broad.mit.edu	37	19	5456148	5456148	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:5456148G>A	ENST00000222033.4	+	1	723	c.646G>A	c.(646-648)Gag>Aag	p.E216K		NM_181710.3	NP_859061.3	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4	216	PA.					integral to membrane	zinc ion binding			NS(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GTTCGTGAGCGAGGCCGCCTC	0.667000													65	166					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347439	48347439	+	Missense_Mutation	SNP	A	A	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:48347439A>T	ENST00000319856.4	+	1	968	c.947A>T	c.(946-948)aAt>aTt	p.N316I		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						ACCCTGAGAAATGAAGAGGTA	0.323000													33	76					0	0	1	0	0
PPP1R13B	23368	broad.mit.edu	37	14	104263810	104263810	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:104263810C>T	ENST00000202556.9	-	2	337	c.55G>A	c.(55-57)Gaa>Aaa	p.E19K		NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	19					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				ATAGGAACTTCTGTTAAAATC	0.373000													22	73					0	0	1	0	0
LRRC37A11P	342666	broad.mit.edu	37	17	37199457	37199457	+	RNA	SNP	T	T	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:37199457T>A	ENST00000425901.2	+	0	2610					NR_033753.2																						GGTAGGAATCTTGGTTGCAAT	0.353000													39	93					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43623833	43623833	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:43623833C>T	ENST00000372806.3	+	6	723	c.628C>T	c.(628-630)Ctg>Ttg	p.L210L	STK4_ENST00000499879.2_Silent_p.L155L|STK4_ENST00000372801.1_Silent_p.L210L|STK4_ENST00000396731.4_Silent_p.L210L	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	210	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				CATCTGGTCCCTGGGAATAAC	0.468000													22	84					0	0	1	0	0
CD177	57126	broad.mit.edu	37	19	43864550	43864550	+	RNA	SNP	A	A	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:43864550A>T	ENST00000378009.4	+	0	914				CD177_ENST00000607517.1_RNA	NM_020406.2	NP_065139.2	Q8N6Q3	CD177_HUMAN	CD177 molecule						blood coagulation|leukocyte migration	anchored to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	5		Prostate(69;0.00682)				TGCTGCTCCTAGATGTAGGTA	0.552000													5	18					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128366356	128366356	+	Missense_Mutation	SNP	A	A	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:128366356A>G	ENST00000389524.4	+	22	2770	c.2717A>G	c.(2716-2718)tAc>tGc	p.Y906C	MYO7B_ENST00000428314.1_Missense_Mutation_p.Y906C|MYO7B_ENST00000409816.2_Missense_Mutation_p.Y906C			Q6PIF6	MYO7B_HUMAN	myosin VIIB	906						apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		AGATCCATCTACGACACCGTC	0.632000													11	33					0	0	1	0	0
PHF21A	51317	broad.mit.edu	37	11	45970444	45970444	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:45970444C>T	ENST00000257821.4	-	13	1904	c.1281G>A	c.(1279-1281)cgG>cgA	p.R427R	PHF21A_ENST00000527753.1_5'UTR|PHF21A_ENST00000323180.6_Silent_p.R427R|PHF21A_ENST00000418153.2_Silent_p.R426R	NM_001101802.1	NP_001095272.1	Q96BD5	PF21A_HUMAN	PHD finger protein 21A	426					blood coagulation|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription, DNA-dependent|transcription, DNA-dependent	histone deacetylase complex	DNA binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(10)|lung(9)|skin(2)|upper_aerodigestive_tract(2)	29						CACCTCTCTTCCGGGTCCCAG	0.478000													19	175					0	0	1	0	0
VPS54	51542	broad.mit.edu	37	2	64144059	64144059	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:64144059C>G	ENST00000354504.3	-	13	2333	c.1744G>C	c.(1744-1746)Gag>Cag	p.E582Q	VPS54_ENST00000272322.4_Missense_Mutation_p.E735Q|VPS54_ENST00000409558.3_Missense_Mutation_p.E723Q			Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	735					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						TGTTGTCCCTCGACAATAAGA	0.383000													9	74					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10214474	10214474	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:10214474C>T	ENST00000418404.3	-	32	4765	c.4602G>A	c.(4600-4602)aaG>aaA	p.K1534K	MYH13_ENST00000570743.1_Silent_p.K1534K|MYH13_ENST00000252172.4_Silent_p.K1534K			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1534					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CCACTAGCTTCTTGGTCTTTT	0.453000													31	81					0	0	1	0	0
INSL3	3640	broad.mit.edu	37	19	17927681	17927681	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:17927681C>T	ENST00000379695.5	-	3	540	c.473G>A	c.(472-474)tGa>tAa	p.*158*	INSL3_ENST00000317306.7_Silent_p.L126L	NM_001265587.1	NP_001252516.1	P51460	INSL3_HUMAN	insulin-like 3 (Leydig cell)	0					cell-cell signaling|spermatogenesis	soluble fraction	hormone activity|insulin receptor binding|signal transducer activity			breast(1)|lung(1)	2						GACAGAGGGTCAGCAGGTCTT	0.627000													10	65					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48542384	48542384	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:48542384G>C	ENST00000358350.4	-	46	6885	c.6281C>G	c.(6280-6282)cCt>cGt	p.P2094R	FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000507873.2_5'UTR|FRYL_ENST00000503238.1_Missense_Mutation_p.P2094R|FRYL_ENST00000537810.1_Missense_Mutation_p.P2094R	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	2094					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CAATTGGGAAGGATCCACCAA	0.368000													22	48					0	0	1	0	0
MYH6	4624	broad.mit.edu	37	14	23871676	23871676	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:23871676C>T	ENST00000405093.3	-	12	1208	c.1138G>A	c.(1138-1140)Gaa>Aaa	p.E380K	MYH6_ENST00000356287.3_Missense_Mutation_p.E380K	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	380	Myosin head-like.				adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CTCCCACCTTCGGTGCCGTCT	0.632000													52	190					0	0	1	0	0
FOXRED2	80020	broad.mit.edu	37	22	36889734	36889734	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:36889734G>C	ENST00000397224.4	-	8	1834	c.1741C>G	c.(1741-1743)Ctg>Gtg	p.L581V	FOXRED2_ENST00000366463.3_Missense_Mutation_p.L133V|FOXRED2_ENST00000397223.4_Missense_Mutation_p.L581V|FOXRED2_ENST00000216187.6_Missense_Mutation_p.L581V	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	581					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						AAGCGCCTCAGAGGTAGGATG	0.567000													17	74					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168189549	168189549	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:168189549G>A	ENST00000519560.1	-	15	2024	c.1605C>T	c.(1603-1605)acC>acT	p.T535T	SLIT3_ENST00000404867.3_Silent_p.T535T|SLIT3_ENST00000332966.8_Silent_p.T535T	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	535					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTACAGGTCGGTGACATATT	0.627000													44	102					0	0	1	0	0
PHLDB2	90102	broad.mit.edu	37	3	111632360	111632360	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:111632360G>A	ENST00000431670.2	+	3	1941	c.1530G>A	c.(1528-1530)cgG>cgA	p.R510R	PHLDB2_ENST00000477695.1_Silent_p.R510R|PHLDB2_ENST00000393925.3_Silent_p.R510R|PHLDB2_ENST00000412622.1_Silent_p.R510R|PHLDB2_ENST00000495180.1_Silent_p.R96R|PHLDB2_ENST00000481953.1_Silent_p.R510R|PHLDB2_ENST00000393923.3_Silent_p.R537R	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	510						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GGTGCCACCGGAAAGACTCCC	0.527000													38	210					0	0	1	0	0
MARS2	92935	broad.mit.edu	37	2	198570150	198570150	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:198570150C>T	ENST00000282276.6	+	1	64	c.21C>T	c.(19-21)ctC>ctT	p.L7L	AC011997.1_ENST00000409845.1_Intron	NM_138395.3	NP_612404.1	Q96GW9	SYMM_HUMAN	methionyl-tRNA synthetase 2, mitochondrial	7					methionyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|methionine-tRNA ligase activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	22					L-Methionine(DB00134)	CGTCCGTCCTCCGCCTGCTAG	0.677000													17	109					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109698455	109698455	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:109698455G>C	ENST00000338432.7	+	48	6786	c.6667G>C	c.(6667-6669)Gag>Cag	p.E2223Q	ACACB_ENST00000543201.1_3'UTR|ACACB_ENST00000377854.5_Missense_Mutation_p.E2153Q|ACACB_ENST00000377848.3_Missense_Mutation_p.E2223Q			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2223	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	TGCAGACAAAGAGAGCAGGTG	0.557000													52	204					0	0	1	0	0
LGR5	8549	broad.mit.edu	37	12	71834018	71834018	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:71834018C>G	ENST00000266674.5	+	1	469	c.158C>G	c.(157-159)tCc>tGc	p.S53C	LGR5_ENST00000536515.1_Missense_Mutation_p.S53C|TSPAN8_ENST00000393330.2_Intron|LGR5_ENST00000540815.2_Missense_Mutation_p.S53C			O75473	LGR5_HUMAN	leucine-rich repeat containing G protein-coupled receptor 5	53	LRRNT.					integral to plasma membrane	protein-hormone receptor activity		NUP107/LGR5(2)	endometrium(2)|kidney(3)|large_intestine(2)|lung(24)|ovary(1)|pancreas(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(3)	48						GTGGACTGCTCCGACCTGGGG	0.622000													22	90					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28508179	28508179	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:28508179G>A	ENST00000261609.7	-	15	2115	c.2007C>T	c.(2005-2007)tcC>tcT	p.S669S		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	669					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TCAAAGCAATGGAAAACTGAC	0.448000													51	81					0	0	1	0	0
POLG2	11232	broad.mit.edu	37	17	62492937	62492937	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:62492937G>A	ENST00000539111.2	-	1	217	c.150C>T	c.(148-150)ctC>ctT	p.L50L		NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	50					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			CGTTCCCCTCGAGCTCCGCGT	0.607000													36	173					0	0	1	0	0
FGD1	2245	broad.mit.edu	37	X	54472809	54472809	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:54472809G>A	ENST00000375135.3	-	18	3352	c.2619C>T	c.(2617-2619)ttC>ttT	p.F873F		NM_004463.2	NP_004454.2	P98174	FGD1_HUMAN	FYVE, RhoGEF and PH domain containing 1	873	PH 2.				actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|organ morphogenesis|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|nucleus|plasma membrane|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GTCCCACCTCGAAGCCAATGA	0.652000													14	7					0	0	1	0	0
PRDM15	63977	broad.mit.edu	37	21	43256743	43256743	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr21:43256743C>T	ENST00000422911.1	-	9	1229	c.1128G>A	c.(1126-1128)caG>caA	p.Q376Q	PRDM15_ENST00000538201.1_Silent_p.Q339Q|PRDM15_ENST00000398548.1_Silent_p.Q376Q|PRDM15_ENST00000269844.3_Silent_p.Q705Q|PRDM15_ENST00000447207.2_Silent_p.Q339Q			P57071	PRD15_HUMAN	PR domain containing 15	705					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(11)|ovary(3)|skin(2)|stomach(2)|urinary_tract(1)	43						TGGTGTTATTCTGATGATGGG	0.512000													29	106					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46245204	46245204	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:46245204C>G	ENST00000334344.6	+	15	3470	c.3298C>G	c.(3298-3300)Cag>Gag	p.Q1100E	ARID2_ENST00000444670.1_Missense_Mutation_p.Q710E|ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Missense_Mutation_p.Q951E	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1100	Gln-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.Q1100E(1)		NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GGTGGTCTATCAGGTGGCCAG	0.532000			"""N, S, F"""		hepatocellular carcinoma								14	120					0	0	1	0	0
ZNF418	147686	broad.mit.edu	37	19	58437871	58437871	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:58437871G>A	ENST00000396147.1	-	4	1969	c.1678C>T	c.(1678-1680)Cac>Tac	p.H560Y	ZNF418_ENST00000595830.1_Missense_Mutation_p.H560Y|ZNF418_ENST00000425570.3_Missense_Mutation_p.H581Y|ZNF418_ENST00000600989.1_Intron|ZNF418_ENST00000599852.1_Missense_Mutation_p.H475Y	NM_133460.1	NP_597717.1	Q8TF45	ZN418_HUMAN	zinc finger protein 418	560					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	31		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0158)		TCTGCAGTGTGAGTTTTCTGA	0.448000													36	73					0	0	1	0	0
SERPINF2	5345	broad.mit.edu	37	17	1657732	1657732	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:1657732G>A	ENST00000324015.3	+	10	1457	c.1380G>A	c.(1378-1380)ctG>ctA	p.L460L	SERPINF2_ENST00000382061.4_Silent_p.L460L|SERPINF2_ENST00000450523.2_Silent_p.L396L	NM_000934.3	NP_000925.2	P08697	A2AP_HUMAN	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	460					acute-phase response|fibrinolysis|platelet activation|platelet degranulation|regulation of proteolysis	extracellular space|platelet alpha granule lumen	protease binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(1)|kidney(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)	Streptokinase(DB00086)	TCCAGAGCCTGAAAGGCTTCC	0.617000													49	118					0	0	1	0	0
CXCL12	6387	broad.mit.edu	37	10	44876268	44876268	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr10:44876268C>T	ENST00000374429.2	-	2	208	c.122G>A	c.(121-123)aGa>aAa	p.R41K	AL137026.1_ENST00000593376.1_Intron|CXCL12_ENST00000395795.4_Missense_Mutation_p.R41K|CXCL12_ENST00000343575.6_Missense_Mutation_p.R41K|CXCL12_ENST00000496375.1_5'UTR|CXCL12_ENST00000374426.2_Missense_Mutation_p.R41K|CXCL12_ENST00000395794.2_Missense_Mutation_p.R41K|CXCL12_ENST00000395793.3_Intron	NM_000609.5|NM_001277990.1	NP_000600.1|NP_001264919.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	41					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	GACGTTGGCTCTGGCAACATG	0.463000													57	218					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54754935	54754935	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:54754935G>C	ENST00000450632.1	-	13	1777	c.1700C>G	c.(1699-1701)tCt>tGt	p.S567C	LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron|LILRB5_ENST00000345866.6_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	368					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GAATTCCCCAGACAGTGGGGA	0.592000													7	45					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22637707	22637707	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:22637707G>A	ENST00000333957.4	-	13	1729	c.1474C>T	c.(1474-1476)Cct>Tct	p.P492S	C2CD5_ENST00000542676.1_Missense_Mutation_p.P492S|C2CD5_ENST00000446597.1_Missense_Mutation_p.P492S|C2CD5_ENST00000545552.1_Missense_Mutation_p.P505S|C2CD5_ENST00000396028.2_Missense_Mutation_p.P483S|C2CD5_ENST00000536386.1_Missense_Mutation_p.P494S|C2CD5_ENST00000544930.1_Missense_Mutation_p.P307S	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		AGAACATCAGGAACTTTTTGT	0.378000													12	76					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874077	36874077	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:36874077C>A	ENST00000301807.6	-	21	7112	c.5215G>T	c.(5215-5217)Gcc>Tcc	p.A1739S	TRANK1_ENST00000428977.2_Missense_Mutation_p.A1739S|TRANK1_ENST00000429976.2_Missense_Mutation_p.A2289S	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2289					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding	p.A1739S(1)|p.A1732S(1)|p.A2289S(1)		NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCTTGCATGGCACTCAGCCAC	0.498000													5	64					0.184627	0.185392	1	1	0
TCL6	27004	broad.mit.edu	37	14	96135779	96135779	+	RNA	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:96135779G>C	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		tgttagccaggatggactcca	0.458000			T	TRA@	T-ALL								3	12					0	0	1	0	0
HECTD1	25831	broad.mit.edu	37	14	31641128	31641128	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:31641128C>G	ENST00000399332.1	-	8	1759	c.1271G>C	c.(1270-1272)aGa>aCa	p.R424T	HECTD1_ENST00000553700.1_Missense_Mutation_p.R424T	NM_015382.2	NP_056197.2	Q9ULT8	HECD1_HUMAN	HECT domain containing E3 ubiquitin protein ligase 1	424					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity	p.R424I(1)		breast(10)|endometrium(7)|kidney(5)|large_intestine(12)|lung(23)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	70	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CCTTTGACCTCTATTAACATC	0.289000													18	44					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3677877	3677877	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:3677877G>A	ENST00000344754.4	-	9	2234	c.2235C>T	c.(2233-2235)ttC>ttT	p.F745F	SIGLEC1_ENST00000202578.4_Silent_p.F745F	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	745	Ig-like C2-type 7.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CCCCATTTCGGAACCAGGAGA	0.607000													26	86					0	0	1	0	0
CD4	920	broad.mit.edu	37	12	6923321	6923321	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:6923321G>A	ENST00000011653.4	+	4	486	c.228G>A	c.(226-228)ctG>ctA	p.L76L	CD4_ENST00000541982.1_Silent_p.L21L|CD4_ENST00000538827.1_3'UTR	NM_000616.4|NM_001195015.2|NM_001195016.2|NM_001195017.2	NP_000607.1|NP_001181944.1|NP_001181945.1|NP_001181946.1	P01730	CD4_HUMAN	CD4 molecule	76	Ig-like V-type.				cell adhesion|entry into host cell|immune response|induction by virus of host cell-cell fusion|initiation of viral infection|maintenance of protein location in cell|positive regulation of interleukin-2 biosynthetic process|positive regulation of protein kinase activity|protein palmitoleylation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|T cell selection|transmembrane receptor protein tyrosine kinase signaling pathway	early endosome|endoplasmic reticulum membrane|integral to membrane|T cell receptor complex	coreceptor activity|extracellular matrix structural constituent|glycoprotein binding|MHC class II protein binding|protein homodimerization activity|protein kinase binding|transmembrane receptor activity|zinc ion binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)	23		Myeloproliferative disorder(1001;0.0122)				CATCCAAGCTGAATGATCGCG	0.512000													80	282					0	0	1	0	0
ALMS1	7840	broad.mit.edu	37	2	73677423	73677423	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:73677423C>T	ENST00000264448.6	+	8	3877	c.3766C>T	c.(3766-3768)Cat>Tat	p.H1256Y	ALMS1_ENST00000377715.1_Missense_Mutation_p.H1256Y|ALMS1_ENST00000409009.1_Missense_Mutation_p.H1214Y	NM_015120.4	NP_055935.4	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1256	34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				breast(4)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(31)|lung(68)|ovary(4)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	147						GCCAGATAATCATCCAACTGA	0.468000													34	138					0	0	1	0	0
ZFP69B	65243	broad.mit.edu	37	1	40928867	40928867	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:40928867G>A	ENST00000411995.2	+	6	1586	c.1211G>A	c.(1210-1212)aGa>aAa	p.R404K	ZFP69B_ENST00000484445.1_3'UTR|ZFP69B_ENST00000361584.3_Missense_Mutation_p.R302K	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B																		TTCCAGATTAGACACCTTAGG	0.393000													25	83					0	0	1	0	0
RAD51AP1	10635	broad.mit.edu	37	12	4653036	4653036	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:4653036G>A	ENST00000228843.9	+	3	225	c.175G>A	c.(175-177)Gaa>Aaa	p.E59K	RAD51AP1_ENST00000321524.7_Missense_Mutation_p.E59K|RAD51AP1_ENST00000352618.4_Missense_Mutation_p.E59K|RAD51AP1_ENST00000544927.1_Missense_Mutation_p.E59K|RAD51AP1_ENST00000543041.1_5'UTR	NM_001130862.1	NP_001124334.1	Q96B01	R51A1_HUMAN	RAD51 associated protein 1	59					double-strand break repair via homologous recombination		double-stranded DNA binding|protein binding|RNA binding|single-stranded DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|upper_aerodigestive_tract(1)	13			Colorectal(7;0.00306)|COAD - Colon adenocarcinoma(12;0.0389)			CCGGAAAGAAGAAATCCCAGT	0.348000													15	64					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140969369	140969369	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chrX:140969369C>G	ENST00000298296.1	+	4	696	c.696C>G	c.(694-696)ttC>ttG	p.F232L	MAGEC3_ENST00000443323.2_Intron|MAGEC3_ENST00000448920.1_Intron|MAGEC3_ENST00000536088.1_Intron	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	232	MAGE 1.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					CCCGTGAGTTCATAGAGATTC	0.453000													50	63					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000556131.1_Missense_Mutation_p.G12V|KRAS_ENST00000256078.4_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			8	26					0.000157383	0.000160925	1	1	0
SRGAP3	9901	broad.mit.edu	37	3	9055495	9055495	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:9055495C>T	ENST00000383836.3	-	16	2272	c.1845G>A	c.(1843-1845)caG>caA	p.Q615Q	SRGAP3_ENST00000360413.3_Silent_p.Q591Q	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	615	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		TTTGTTGGATCTGGTGCACCC	0.542000			T	RAF1	pilocytic astrocytoma								27	69					0	0	1	0	0
APOL4	80832	broad.mit.edu	37	22	36587709	36587709	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr22:36587709C>A	ENST00000332987.1	-	7	880	c.458G>T	c.(457-459)gGc>gTc	p.G153V	APOL4_ENST00000479929.1_5'UTR|APOL4_ENST00000404685.3_3'UTR|APOL4_ENST00000352371.1_Missense_Mutation_p.G156V|APOL4_ENST00000405511.1_3'UTR|APOL4_ENST00000429038.2_3'UTR			Q9BPW4	APOL4_HUMAN	apolipoprotein L, 4	157					lipid metabolic process|lipid transport|lipoprotein metabolic process	extracellular region	lipid binding			lung(1)	1						CAACATAACGCCAATGACAGA	0.552000													13	45					2.32078e-09	2.47029e-09	1	1	0
CHN1	1123	broad.mit.edu	37	2	175677110	175677110	+	Silent	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:175677110C>T	ENST00000409900.3	-	9	1126	c.813G>A	c.(811-813)acG>acA	p.T271T	CHN1_ENST00000409597.1_Silent_p.T87T|CHN1_ENST00000295497.7_Silent_p.T146T|CHN1_ENST00000409156.3_Silent_p.T245T|CHN1_ENST00000488080.1_5'UTR	NM_001822.5	NP_001813.1	P15882	CHIN_HUMAN	chimerin 1	271	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(117;0.226)			TCACGAGCGTCGTAAGGTCAC	0.478000			T	TAF15	extraskeletal myxoid chondrosarcoma								30	146					0	0	1	0	0
ADCY5	111	broad.mit.edu	37	3	123066634	123066634	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:123066634G>T	ENST00000462833.1	-	3	2613	c.1401C>A	c.(1399-1401)aaC>aaA	p.N467K	ADCY5_ENST00000491190.1_Missense_Mutation_p.N100K|ADCY5_ENST00000309879.5_Missense_Mutation_p.N117K	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	467					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		CCTACCTCACGTTGTCATGTT	0.537000													57	312					7.10663e-31	8.13625e-31	1	1	0
C11orf1	64776	broad.mit.edu	37	11	111754494	111754494	+	Splice_Site	SNP	G	G	T	rs145116726		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr11:111754494G>T	ENST00000260276.3	+	4	680		c.e4-1		C11orf1_ENST00000529270.1_Splice_Site|C11orf1_ENST00000528125.1_Splice_Site|C11orf1_ENST00000530214.1_Splice_Site	NM_022761.2	NP_073598.1	Q9H5F2	CK001_HUMAN	chromosome 11 open reading frame 1							nucleus				kidney(2)|lung(3)	5		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		TCTTCCCTCAGGATTTAAGCG	0.398000													20	42					1.33834e-09	1.42874e-09	1	1	0
ADAM22	53616	broad.mit.edu	37	7	87795228	87795228	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr7:87795228G>C	ENST00000398204.4	+	24	2481	c.2158G>C	c.(2158-2160)Gat>Cat	p.D720H	ADAM22_ENST00000265727.7_Missense_Mutation_p.D720H|ADAM22_ENST00000315984.7_Missense_Mutation_p.D720H|ADAM22_ENST00000398201.4_Missense_Mutation_p.D720H|ADAM22_ENST00000398209.3_Missense_Mutation_p.D720H	NM_016351.4|NM_021723.3	NP_057435.2|NP_068369.1	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22	720					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			endometrium(7)|kidney(4)|large_intestine(7)|liver(2)|lung(20)|ovary(6)|prostate(4)|skin(3)	53	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TCACAATGATGATGCAAAGAC	0.393000													13	48					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114824021	114824021	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:114824021G>A	ENST00000315366.7	-	2	2075	c.1209C>T	c.(1207-1209)atC>atT	p.I403I	ARSJ_ENST00000541197.1_Silent_p.I403I	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	403						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		TGGTCTCCCAGATATCATAGC	0.468000													54	151					0	0	1	0	0
ACTBL2	345651	broad.mit.edu	37	5	56778234	56778234	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:56778234C>T	ENST00000423391.1	-	1	402	c.301G>A	c.(301-303)Gag>Aag	p.E101K	CTD-2023N9.1_ENST00000506106.1_RNA	NM_001017992.3	NP_001017992.1	Q562R1	ACTBL_HUMAN	actin, beta-like 2	101						cytoplasm|cytoskeleton	ATP binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(3)|pancreas(1)|prostate(2)	28		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		ATGGGATGCTCATCTGGTGCC	0.512000													9	62					0	0	1	0	0
TLR2	7097	broad.mit.edu	37	4	154624869	154624869	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:154624869G>A	ENST00000260010.6	+	1	2218	c.810G>A	c.(808-810)atG>atA	p.M270I		NM_003264.3	NP_003255.2	O60603	TLR2_HUMAN	toll-like receptor 2	270					cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	29	all_hematologic(180;0.093)	Renal(120;0.117)				TTCAGGTTATGAAACTTTTGA	0.308000													12	58					0	0	1	0	0
HSPA12B	116835	broad.mit.edu	37	20	3726646	3726646	+	Missense_Mutation	SNP	G	G	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr20:3726646G>T	ENST00000254963.2	+	7	788	c.643G>T	c.(643-645)Gcc>Tcc	p.A215S	HSPA12B_ENST00000542646.1_Missense_Mutation_p.A49S	NM_001197327.1|NM_052970.4	NP_001184256.1|NP_443202.3	Q96MM6	HS12B_HUMAN	heat shock 70kD protein 12B	215							ATP binding	p.A215S(1)		NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	14						GAAACAGCCAGCCAAGCAGTT	0.642000													7	127					1.12685e-05	1.16698e-05	1	1	0
TRNT1	51095	broad.mit.edu	37	3	3182296	3182296	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:3182296G>A	ENST00000251607.6	+	4	547	c.445G>A	c.(445-447)Gaa>Aaa	p.E149K	TRNT1_ENST00000280591.6_Missense_Mutation_p.E149K	NM_182916.2	NP_886552.2	Q96Q11	TRNT1_HUMAN	tRNA nucleotidyl transferase, CCA-adding, 1	149					protein targeting to mitochondrion|tRNA 3'-end processing	mitochondrion	ATP binding|tRNA adenylyltransferase activity|tRNA binding			breast(2)|endometrium(3)|large_intestine(4)|lung(2)|urinary_tract(1)	12				Epithelial(13;0.00226)|OV - Ovarian serous cystadenocarcinoma(96;0.00592)|all cancers(10;0.011)		GAAAGATGCGGAACGCAGAGA	0.358000													14	71					0	0	1	0	0
BCL3	602	broad.mit.edu	37	19	45262858	45262858	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:45262858C>T	ENST00000164227.5	+	9	1595	c.1351C>T	c.(1351-1353)Cca>Tca	p.P451S		NM_005178.4	NP_005169.2	P20749	BCL3_HUMAN	B-cell CLL/lymphoma 3	451	Pro/Ser-rich.				DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|I-kappaB kinase/NF-kappaB cascade|maintenance of protein location in nucleus|negative regulation of apoptosis|negative regulation of interleukin-8 biosynthetic process|negative regulation of transcription, DNA-dependent|positive regulation of translation|protein import into nucleus, translocation|regulation of DNA binding|regulation of NF-kappaB import into nucleus|response to UV-C|response to virus	Bcl3-Bcl10 complex|Bcl3/NF-kappaB2 complex|nucleus|perinuclear region of cytoplasm	protein binding, bridging|transcription factor binding			kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10	Lung NSC(12;0.000698)|all_lung(12;0.002)	Ovarian(192;0.0728)				CTCCCCAGCTCCAGGAGGCAG	0.657000			T	IGH@	CLL								24	79					0	0	1	0	0
KL	9365	broad.mit.edu	37	13	33628216	33628216	+	Nonsense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr13:33628216C>T	ENST00000380099.3	+	2	1140	c.1132C>T	c.(1132-1134)Caa>Taa	p.Q378*	KL_ENST00000487852.1_3'UTR|KL_ENST00000426690.2_Nonsense_Mutation_p.Q71*	NM_004795.3	NP_004786.2	Q9UEF7	KLOT_HUMAN	klotho	378	Glycosyl hydrolase-1 1.				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|skin(5)	41	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		CTTGAGTTTTCAACTTTTGGA	0.408000													77	215					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628857	71628857	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:71628857C>T	ENST00000377276.2	-	1	182	c.152G>A	c.(151-153)gGc>gAc	p.G51D		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	51	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						GGAGCCCATGCCCAGCGTCCT	0.587000													4	89					0	0	1	0	0
GRIN3B	116444	broad.mit.edu	37	19	1005107	1005107	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:1005107C>G	ENST00000234389.3	+	3	1626	c.1607C>G	c.(1606-1608)tCc>tGc	p.S536C	GRIN3B_ENST00000588335.1_3'UTR	NM_138690.1	NP_619635.1	O60391	NMD3B_HUMAN	glutamate receptor, ionotropic, N-methyl-D-aspartate 3B	536					ionotropic glutamate receptor signaling pathway|protein insertion into membrane|regulation of calcium ion transport	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|ionotropic glutamate receptor activity|neurotransmitter receptor activity			breast(1)|kidney(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;0.000226)|all_lung(49;0.000353)|Breast(49;0.00066)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)	Glycine(DB00145)|L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	AGTATCAACTCCGCCCGCTCA	0.692000													15	60					0	0	1	0	0
EXOSC10	5394	broad.mit.edu	37	1	11141233	11141233	+	Missense_Mutation	SNP	T	T	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:11141233T>C	ENST00000544779.1	-	11	1348	c.1343A>G	c.(1342-1344)tAt>tGt	p.Y448C	EXOSC10_ENST00000376936.4_Missense_Mutation_p.Y448C|EXOSC10_ENST00000304457.7_Missense_Mutation_p.Y448C|EXOSC10_ENST00000485606.1_5'UTR			Q01780	EXOSX_HUMAN	exosome component 10	448					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		CATTTTGTCATAGATATATAG	0.572000													35	109					0	0	1	0	0
TAGLN2	8407	broad.mit.edu	37	1	159889525	159889525	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:159889525G>C	ENST00000368097.4	-	3	591	c.281C>G	c.(280-282)tCt>tGt	p.S94C	TAGLN2_ENST00000320307.4_Missense_Mutation_p.S94C|TAGLN2_ENST00000368096.1_Missense_Mutation_p.S115C|TAGLN2_ENST00000478033.1_5'UTR	NM_001277223.1|NM_003564.1	NP_001264152.1|NP_003555.1	P37802	TAGL2_HUMAN	transgelin 2	94	CH.				muscle organ development	nuclear membrane|plasma membrane	protein binding			endometrium(1)|large_intestine(2)|lung(6)	9	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CAGGAACTGAGAGATCTGCTC	0.567000													77	390					0	0	1	0	0
RRP36	88745	broad.mit.edu	37	6	42996856	42996856	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr6:42996856G>A	ENST00000244496.5	+	7	680	c.670G>A	c.(670-672)Gag>Aag	p.E224K		NM_033112.2	NP_149103.1	Q96EU6	RRP36_HUMAN	ribosomal RNA processing 36 homolog (S. cerevisiae)	224					ribosomal small subunit biogenesis|rRNA processing	nucleolus				NS(1)|breast(1)|central_nervous_system(1)|large_intestine(5)|lung(1)|ovary(1)|prostate(1)	11						GGCACTAGCTGAGAAGTTCAA	0.483000													75	290					0	0	1	0	0
NTNG1	22854	broad.mit.edu	37	1	107867486	107867486	+	Missense_Mutation	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:107867486G>A	ENST00000370067.1	+	3	1456	c.829G>A	c.(829-831)Gat>Aat	p.D277N	NTNG1_ENST00000370068.1_Missense_Mutation_p.D277N|NTNG1_ENST00000477948.1_3'UTR|NTNG1_ENST00000370071.2_Missense_Mutation_p.D277N|NTNG1_ENST00000370072.3_Missense_Mutation_p.D277N|NTNG1_ENST00000370073.2_Missense_Mutation_p.D277N|NTNG1_ENST00000370074.4_Missense_Mutation_p.D277N|NTNG1_ENST00000542803.1_Missense_Mutation_p.D277N|NTNG1_ENST00000370065.1_Missense_Mutation_p.D277N|NTNG1_ENST00000370070.2_Missense_Mutation_p.D277N|NTNG1_ENST00000370066.1_Missense_Mutation_p.D277N|NTNG1_ENST00000370061.3_Missense_Mutation_p.D277N			Q9Y2I2	NTNG1_HUMAN	netrin G1	277	Laminin N-terminal.				axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		AATATTTGTAGATGAGCTACA	0.463000													26	51					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110791131	110791131	+	Missense_Mutation	SNP	C	C	T	rs77966848	byFrequency	TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:110791131C>T	ENST00000327908.3	+	4	1441	c.677C>T	c.(676-678)tCc>tTc	p.S226F	LRIT3_ENST00000409621.2_Missense_Mutation_p.S226F|LRIT3_ENST00000594814.1_Missense_Mutation_p.S409F|LRIT3_ENST00000379920.3_Missense_Mutation_p.S364F			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	364	Ig-like.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		tctactgcttccttctcttta	0.458000													24	89					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154239025	154239025	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:154239025C>T	ENST00000428931.1	+	25	3118	c.2951C>T	c.(2950-2952)tCt>tTt	p.S984F	UBAP2L_ENST00000484819.1_3'UTR|UBAP2L_ENST00000361546.2_Missense_Mutation_p.S984F|UBAP2L_ENST00000271877.7_Missense_Mutation_p.S995F	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	984					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			ATCTCGGGTTCTGTGTACTCC	0.512000													42	555					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15642940	15642940	+	Missense_Mutation	SNP	C	C	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:15642940C>T	ENST00000321169.5	-	1	398	c.31G>A	c.(31-33)Gag>Aag	p.E11K	HACL1_ENST00000457447.2_Missense_Mutation_p.E11K|HACL1_ENST00000456194.2_Missense_Mutation_p.E11K|HACL1_ENST00000451445.2_Missense_Mutation_p.E11K|HACL1_ENST00000435217.2_Missense_Mutation_p.E11K	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	11					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						ACCTGCTCCTCGCTGCGCTCT	0.567000													27	90					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34135718	34135718	+	Silent	SNP	G	G	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr15:34135718G>A	ENST00000389232.4	+	92	13309	c.13239G>A	c.(13237-13239)ctG>ctA	p.L4413L	RYR3_ENST00000415757.3_Silent_p.L4408L	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	4413					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCTACAACCTGAGGTTCCTTG	0.408000													5	5					0	0	1	0	0
CMTR2	55783	broad.mit.edu	37	16	71319487	71319487	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:71319487G>C	ENST00000338099.5	-	3	673	c.337C>G	c.(337-339)Caa>Gaa	p.Q113E	FTSJD1_ENST00000434935.2_Missense_Mutation_p.Q113E			Q8IYT2	FTSJ1_HUMAN		113						integral to membrane	methyltransferase activity|nucleic acid binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CACCATGCTTGAGTACAAAGT	0.393000													40	93					0	0	1	0	0
ECE2	9718	broad.mit.edu	37	3	183967492	183967492	+	Missense_Mutation	SNP	C	C	G			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:183967492C>G	ENST00000402825.3	+	1	10	c.10C>G	c.(10-12)Cca>Gca	p.P4A	ECE2_ENST00000324557.4_Missense_Mutation_p.P4A|EIF2B5_ENST00000444495.1_Intron	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	4	Methyltransferase-like region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CATGGCCTCTCCAGGGGCAGG	0.677000											OREG0015944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	29					0	0	1	0	0
C9orf172	389813	broad.mit.edu	37	9	139740121	139740121	+	Missense_Mutation	SNP	G	G	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:139740121G>C	ENST00000436881.1	+	1	1255	c.1255G>C	c.(1255-1257)Gac>Cac	p.D419H		NM_001080482.2	NP_001073951.2	C9J069	CI172_HUMAN	chromosome 9 open reading frame 172	419	Pro-rich.									endometrium(2)|large_intestine(1)|lung(6)	9						GCCGCCCTCTGACCCCGACCC	0.741000													4	12					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27518331	27518331	+	Missense_Mutation	SNP	C	C	A			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:27518331C>A	ENST00000356183.4	-	9	1404	c.1389G>T	c.(1387-1389)gaG>gaT	p.E463D	GTF3C1_ENST00000561623.1_Missense_Mutation_p.E463D	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	463						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GAAGCGACTCCTCCTGCATAG	0.612000													15	70					4.14922e-12	4.4955e-12	1	1	0
MATN1	4146	broad.mit.edu	37	1	31196346	31196348	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:31196346_31196348delAGC	ENST00000373765.4	-	1	86_88	c.51_53delGCT	c.(49-54)ctc>ct	p.LL17del	MATN1-AS1_ENST00000454613.1_RNA|MATN1-AS1_ENST00000414532.2_RNA	NM_002379.3	NP_002370.1	P21941	MATN1_HUMAN	matrilin 1, cartilage matrix protein	17					protein complex assembly	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	12		Colorectal(325;0.00792)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)|Ovarian(437;0.0563)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		Colorectal(126;1.29e-05)|COAD - Colon adenocarcinoma(152;0.000726)|STAD - Stomach adenocarcinoma(196;0.0183)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGGCCTGGAGCAGCAGCAGCA	0.665													2	4	---	---	---	---					
RAB3GAP2	25782	broad.mit.edu	37	1	220324614	220324633	+	Frame_Shift_Del	DEL	GGCTTCCACAGCTTCAATGA	GGCTTCCACAGCTTCAATGA	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr1:220324614_220324633delGGCTTCCACAGCTTCAATGA	ENST00000358951.2	-	35	4258_4277	c.4142_4161delTCATTGAAGCTGTGGAAGCC	c.(4141-4161)cfs	p.LIEAVEA1381fs		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	1381					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		GAAGAGATATGGCTTCCACAGCTTCAATGAGGTGTAAGGC	0.355													19	110	---	---	---	---					
ALPP	250	broad.mit.edu	37	2	233243529	233243531	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr2:233243529_233243531delTGC	ENST00000392027.2	+	1	286_288	c.17_19delTGC	c.(16-21)atg>a	p.ML6del		NM_001632.3	NP_001623.3	P05187	PPB1_HUMAN	alkaline phosphatase, placental	6						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			NS(1)|biliary_tract(1)|endometrium(1)|kidney(4)|large_intestine(2)|liver(1)|lung(10)|ovary(2)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GGGCCCTGCAtgctgctgctgct	0.616													9	178	---	---	---	---					
MUC4	4585	broad.mit.edu	37	3	195512373	195512374	+	In_Frame_Ins	INS	-	-	GAT	rs63118461	by1000genomes	TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr3:195512373_195512374insGAT	ENST00000463781.3	-	2	6536_6537	c.6077_6078insATC	c.(6076-6078)tac>tATCac	p.2026_2027insH	MUC4_ENST00000475231.1_In_Frame_Ins_p.2026_2027insH|MUC4_ENST00000346145.4_Intron|MUC4_ENST00000349607.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	798					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.S2026_T2027insS(3)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGTCACCAGTGGATGCTGAGGA	0.579													5	5	---	---	---	---					
TRMT10A	93587	broad.mit.edu	37	4	100480443	100480443	+	Frame_Shift_Del	DEL	T	T	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr4:100480443delT	ENST00000273962.3	-	2	365	c.53delA	c.(52-54)agfs	p.K18fs	TRMT10A_ENST00000394876.2_Frame_Shift_Del_p.K18fs|TRMT10A_ENST00000394877.3_Frame_Shift_Del_p.K18fs	NM_152292.4	NP_689505.1			tRNA methyltransferase 10 homolog A (S. cerevisiae)																		TATGCCTTGCTTTTTGTCAAC	0.338													20	109	---	---	---	---					
FASTKD3	79072	broad.mit.edu	37	5	7868116	7868117	+	Frame_Shift_Ins	INS	-	-	T			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr5:7868116_7868117insT	ENST00000264669.5	-	2	216_217	c.80_81insA	c.(79-81)aaafs	p.K27fs	MTRR_ENST00000502509.1_Intron|FASTKD3_ENST00000513658.1_Intron	NM_024091.3	NP_076996.2	Q14CZ7	FAKD3_HUMAN	FAST kinase domains 3	27					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(2)|lung(11)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						TTAGAGGTTTATTTTTTAAAGC	0.421													15	110	---	---	---	---					
CSMD3	114788	broad.mit.edu	37	8	113504765	113504765	+	Frame_Shift_Del	DEL	C	C	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr8:113504765delC	ENST00000297405.5	-	31	5475	c.5231delG	c.(5230-5232)gafs	p.G1744fs	CSMD3_ENST00000352409.3_Frame_Shift_Del_p.G1744fs|CSMD3_ENST00000343508.3_Frame_Shift_Del_p.G1704fs|CSMD3_ENST00000455883.2_Frame_Shift_Del_p.G1640fs	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1744	Sushi 9.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCCATCATCTCCCATGATACA	0.368										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			84	184	---	---	---	---					
VCP	7415	broad.mit.edu	37	9	35061014	35061014	+	Frame_Shift_Del	DEL	G	G	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr9:35061014delG	ENST00000358901.6	-	11	2252	c.1357delC	c.(1357-1359)ggfs	p.R453fs		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	453					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GTCCTTACCCGGAAGTCATCC	0.507													148	504	---	---	---	---					
OR4N2	390429	broad.mit.edu	37	14	20295822	20295823	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:20295822_20295823delCC	ENST00000315947.1	+	1	215_216	c.215_216delCC	c.(214-216)tfs	p.S72fs	OR4N2_ENST00000568211.1_Frame_Shift_Del_p.S72fs	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	72					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTGGATGCATCCTACTCCTTCA	0.490													114	568	---	---	---	---					
SNHG23	100507242	broad.mit.edu	37	14	101421669	101421669	+	RNA	DEL	C	C	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr14:101421669delC	ENST00000556637.1	+	0	399																											TAGGAAACAGCTTACAAATAA	0.373													9	57	---	---	---	---					
GPT2	84706	broad.mit.edu	37	16	46956285	46956286	+	Frame_Shift_Ins	INS	-	-	C			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr16:46956285_46956286insC	ENST00000440783.2	+	9	1534_1535	c.869_870insC	c.(868-870)accfs	p.T290fs	GPT2_ENST00000340124.4_Frame_Shift_Ins_p.T390fs	NM_001142466.1	NP_001135938.1	Q8TD30	ALAT2_HUMAN	glutamic pyruvate transaminase (alanine aminotransferase) 2	390					2-oxoglutarate metabolic process|cellular amino acid biosynthetic process|L-alanine metabolic process	mitochondrial matrix	L-alanine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	23		all_cancers(37;0.0276)|all_epithelial(9;0.0498)|all_lung(18;0.0522)			L-Alanine(DB00160)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	ATTGTCGTGAACCCCCCGGTGG	0.629													22	190	---	---	---	---					
FLJ36000	284124	broad.mit.edu	37	17	21911673	21911673	+	RNA	DEL	C	C	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:21911673delC	ENST00000581223.2	+	0	2398					NR_027084.1																						CAACCAAAGTCAAAGAAGATT	0.448													4	5	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													9	148	---	---	---	---					
POLI	11201	broad.mit.edu	37	18	51795958	51795960	+	In_Frame_Del	DEL	CGA	CGA	-	rs140689079		TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr18:51795958_51795960delCGA	ENST00000579534.1	+	1	185_187	c.42_44delCGA	c.(40-45)ggc>gg	p.GD14del	POLI_ENST00000579434.1_5'UTR|POLI_ENST00000406285.3_In_Frame_Del_p.GD14del	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	14					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding	p.D17delD(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		AAGGCGGCGGCGACGACGACGAG	0.729								DNA polymerases (catalytic subunits)					4	6	---	---	---	---					
ZNF66	7617	broad.mit.edu	37	19	20989697	20989697	+	Frame_Shift_Del	DEL	G	G	-			TCGA-93-8067-01A-11D-2284-08	TCGA-93-8067-10A-01D-2284-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e51886ea-caf5-4850-bd2c-3bca2e143c5b	d7d83255-5abb-4081-b6f9-521a376a2f76	g.chr19:20989697delG	ENST00000344519.8	+	4	1314	c.1291delG	c.(1291-1293)gcfs	p.G431fs	ZNF66_ENST00000425625.1_Intron														p.G431C(1)									TGAAGAATGTGGCAAAGCCTT	0.413													11	84	---	---	---	---					
